Gene PTPRD-35 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP090_AA protein Get Run
AqueP090_AA_1315-1403 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1309-1403 2.7e-67 217.0 In-house 1-95 (95) alignment 
Range on Protein: 1309-1403
Range on HMM: 1-95/95.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDSDYINACFVDGYARKNCYIAAQG
||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
efkpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaqg
subfamily_PTPRD_pd Subfamily PTPRD 1311-1403 4.5e-30 99.8 In-house 3-98 (564) alignment 
Range on Protein: 1311-1403
Range on HMM: 3-98/564.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKNCYIAAQG
|||.|. ...|| ....|||..|..|.|.| . .  . .. . .|| .|||. || .||..||||.    . .|||||| |.||| ... |||.||
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqg
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1311-1403 2.2e-21 71.3 In-house 3-98 (319) alignment 
Range on Protein: 1311-1403
Range on HMM: 3-98/319.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQG
..|.|  ..... ...|.... ...||| . ...   ..  | | | .|||. || .|| |||||..   . .|||||| |.||| ... .||.|.
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqa
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1313-1403 3e-21 70.8 In-house 2-96 (318) alignment 
Range on Protein: 1313-1403
Range on HMM: 2-96/318.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSI-PMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTK---RDSDYINACFVDGYARKNCYIAAQG
|.|. ..||| ..... . ....|.. . . .. .  .   ...|  |||. || .|| ||| |...    .|||||| ..||| ||. |||||.
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqa
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1311-1403 5.6e-21 70.0 In-house 2-96 (305) alignment 
Range on Protein: 1311-1403
Range on HMM: 2-96/305.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTsGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDS---DYINACFVDGYARKNCYIAAQG
|.| .. ..... |....||.......||.... . .. ||..|||  |||. .|...|  |. ||.| .    |||||..|||| ||..||.|||
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqg
subfamily_PTPRG_pd Subfamily PTPRG 1313-1403 1.9e-20 67.6 In-house 1-98 (563) alignment 
Range on Protein: 1313-1403
Range on HMM: 1-98/563.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPMT---SGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTT----KRDSDYINACFVDGYARKNCYIAAQG
..|. |..|| ..|...|. |..||... ..   .  ...  . . |  ||| ||| .|| .|| |.     |.. ||||| ..||| ... .||.||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqg
0051299 (Phosphotyrosine protein) phosphatases II 1312-1403 4.4e-20 67.7 In-house 4-99 (288) alignment 
Range on Protein: 1312-1403
Range on HMM: 4-99/288.0
PIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTS-GAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQG
.|.|. ....||... |.   . .||. ..      ...... ..|..|||. .|.||| .||.|..  .   |||||| ..||| .|. .||.||
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqg
subfamily_PTPRB_pd Subfamily PTPRB 1309-1403 1.1e-19 65.6 In-house 3-101 (293) alignment 
Range on Protein: 1309-1403
Range on HMM: 3-101/293.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMT-SGAPYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQG
. |||... |..|| .|...|| .| .|....    .    .. ....|  |||. || |||..|| |   .....|||||| ...||  .. .||.||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG
subfamily_PTPRA_pd Subfamily PTPRA 1309-1403 2.4e-19 64.4 In-house 10-108 (330) alignment 
Range on Protein: 1309-1403
Range on HMM: 10-108/330.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPM-TSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQG
.. |. |  .   .    ..  . | .||...|  .  | . . | | |  |||..||.||| .||.|..|.   .|||||| |.||| .|. .|||||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqG
0040438 (Phosphotyrosine protein) phosphatases II 1319-1403 2.6e-19 65.1 In-house 6-93 (317) alignment 
Range on Protein: 1319-1403
Range on HMM: 6-93/317.0
HSHVLEMHSNSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQG
. ..| .. .. . . .||. ..  .  .|.|.. ..|..|||. .|.|||..||.|.       |||||| .|||. .|. .||.||
llalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1312-1403 6.4e-19 63.1 In-house 3-97 (288) alignment 
Range on Protein: 1312-1403
Range on HMM: 3-97/288.0
PIHVSVFhSHVLEMHSNSDQEFDNEFKSI-PMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQG
|||.|   ..| ... .. ..| .|..|. .. .    |.|.   | .|||. || ||| .|| |.    ....||||| ..||. .|. |||.||
pihispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqg
0039614 (Phosphotyrosine protein) phosphatases II 1309-1403 1e-18 63.3 In-house 10-108 (297) alignment 
Range on Protein: 1309-1403
Range on HMM: 10-108/297.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGaPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD----SDYINACFVDGYAR-KNCYIAAQG
|. ||..||.. ..| .. || . ...||....     .|... ...|..|||. .|.||| .||.|.....    |||||| .|||| . .. .||.||
esipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg
0050432 (Phosphotyrosine protein) phosphatases II 1311-1403 1e-18 63.2 In-house 22-115 (308) alignment 
Range on Protein: 1311-1403
Range on HMM: 22-115/308.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSG-APYTVGSSEANIPKNRFLNIFPYDATRVVLttKRDSDYINACFVDGY--ARKNCYIAAQG
. ...|| . . | .. .. . .. ||. ....    .|.|.. ..|..|||. .|.||| .||.|  . .|||||| .||||   ... .||.||
sslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqg
0045450 (Phosphotyrosine protein) phosphatases II 1308-1403 1.5e-17 59.7 In-house 4-114 (307) alignment 
Range on Protein: 1308-1403
Range on HMM: 4-114/307.0
NEFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSG---APYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD----SDYINACFV--------DGY
.  ..| . .. ..||... .. . .  ||....        .|.......|..|||. .|.||| |||.|..  .    |||||| .|        |||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

ARKNCYIAAQG
 .|. .||.||
dlkrkfIatqg
0043336 (Phosphotyrosine protein) phosphatases II 1313-1403 1.7e-17 59.2 In-house 2-95 (278) alignment 
Range on Protein: 1313-1403
Range on HMM: 2-95/278.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQG
|.|. .. ..||.. |. . . .||....     .|... ...|..|||. .|.||| .||.|.      ||||||| .|||| ... .||.||
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqg
0046845 (Phosphotyrosine protein) phosphatases II 1333-1403 4.5e-17 57.8 In-house 2-84 (284) alignment 
Range on Protein: 1333-1403
Range on HMM: 2-84/284.0
FDNEFKSIPMTSGA---PYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD----SDYINACFVDGY-----ARKNCYIAAQG
.. ||. ...       ...|.  ..|. |||. .|.||| .||.|..  .    |||||| .||||      .|. .||.||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqg
0047943 (Phosphotyrosine protein) phosphatases II 1326-1403 5.9e-17 57.5 In-house 7-84 (273) alignment 
Range on Protein: 1326-1403
Range on HMM: 7-84/273.0
HSNSDQEFDNEFKSIPMTS-GAPYTVGSSEANIPKNRFLNIFPYDATRVVLtTKRDSDYINACFVDGYARKNCYIAAQG
.... . .  ||. .. .    .|.|.. ..|. |||. .|.||| .||.| .  .|||||| .|||| .|. .||.||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqg
0036941 (Phosphotyrosine protein) phosphatases II 1338-1403 7e-17 57.1 In-house 20-85 (297) alignment 
Range on Protein: 1338-1403
Range on HMM: 20-85/297.0
KSI-PMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLtTKRDSDYINACFVDGYARKNCYIAAQG
... |.    ...|.....|..|||. .|.||| |||.| .. .||||||..|||| .|. .||.||
eellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1324-1402 1.1e-16 55.9 In-house 20-105 (298) alignment 
Range on Protein: 1324-1402
Range on HMM: 20-105/298.0
EMHSNSDQEFDNEFKSIPMTSG----APYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
 .....   ...||. .  .|     . ..|.....|  |||. .| ..| .||||..   . .|||||| |...| ..| .||.|
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1320-1403 5e-16 53.6 In-house 4-91 (281) alignment 
Range on Protein: 1320-1403
Range on HMM: 4-91/281.0
SHVLEMHSNSDQEFDNEFKSIPM-TSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKNCYIAAQG
 |. ....|... | .|....     . . |   ...|. |||. ||. ||||||..|   .. ..||||| ||.||  .. |||.||
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1313-1403 5.6e-16 53.4 In-house 2-93 (287) alignment 
Range on Protein: 1313-1403
Range on HMM: 2-93/287.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPM--TSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTtKRDSDYINACFVDGYARKNCYIAAQG
| |. |   | . | .....| | |. .     .    |.. .. | .|||. .| ..|  ||.|  ... |||||.|.|||  |. .|.|..
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiaes
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1310-1403 6.4e-16 53.2 In-house 3-99 (315) alignment 
Range on Protein: 1310-1403
Range on HMM: 3-99/315.0
FKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQG
..|| .  . ..| . .... . | ....|||     |  |     |  |||. || .|| .|| |    .. .|||.|| |.|||..|. ||||||
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqg
fn3 Fibronectin type III domain 566-640 7.7e-16 51.2 Pfam-A 8-84 (85) alignment 
Range on Protein: 566-640
Range on HMM: 8-84/85.0
MNDFSPYSLLIVWNPPTMPNGIITVYEIRYRESISTD-PHNITNTTST-QYNIVGLTPNTSYTIEVRAFTSIGPGEW
. . .. || . |.||. ..| || ||..|||. ... ....|.. .| .... ||.|.|.|...|.| .  | |..
vsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1313-1403 1.3e-15 52.1 In-house 2-98 (290) alignment 
Range on Protein: 1313-1403
Range on HMM: 2-98/290.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPMT-SGAPYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRD--SDYINACFVDGYARKNCYIAAQG
| |. |  .| . |.. .. | |.||..  . |    ||| .. | ..||| || .||  |..|     ..|   .|||||...||  |. |||.||
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqg
subfamily_Ptp69D_pd Subfamily Ptp69D 1313-1403 1.4e-15 52.2 In-house 4-98 (307) alignment 
Range on Protein: 1313-1403
Range on HMM: 4-98/307.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPM-TSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKNCYIAAQG
|..   .. .   . ..|. . .|.....  ..    .|.  . |  |||. .| ..| |||.|.    | ||||||| |. ||  |. .||||.
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqd
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1316-1402 6.7e-15 50.0 In-house 8-97 (325) alignment 
Range on Protein: 1316-1402
Range on HMM: 8-97/325.0
SVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQ
  .  || . ... .. | .||. .|   |  ..|    .|. |||| |. ..| .|||| ||.|   |||||| ..  . .|. ..|||
vnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaq
DSPc_SM00195 1333-1403 3.2e-14 48.2 In-house 2-76 (263) alignment 
Range on Protein: 1333-1403
Range on HMM: 2-76/263.0
FDNEFKSIPMTS-GAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQG
...||... .     . | .  ..|  |||. ||.||| ||| |...    .|||||| ...|. .|. |||.||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQg
PTPc_SM00194 1333-1403 3.2e-14 48.2 In-house 2-76 (263) alignment 
Range on Protein: 1333-1403
Range on HMM: 2-76/263.0
FDNEFKSIPMTS-GAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQG
...||... .     . | .  ..|  |||. ||.||| ||| |...    .|||||| ...|. .|. |||.||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQg
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1330-1403 6.3e-14 47.0 In-house 33-111 (319) alignment 
Range on Protein: 1330-1403
Range on HMM: 33-111/319.0
DQEFDNEFKSIPMT--SGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQG
 ...  ||. ..    ..|  |    . |  |||. ||...| ..| |     .  |||||| ||.|| ||. ||||||
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqG
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1331-1403 7.5e-14 45.7 In-house 18-93 (515) alignment 
Range on Protein: 1331-1403
Range on HMM: 18-93/515.0
QEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQG
  | .||. .|     | ||   | | .|||. ||.||| .|| |     . .|||.|| .. ..   ..|||.||
tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqg
0045098 (Phosphotyrosine protein) phosphatases II 1338-1403 8.1e-14 47.1 In-house 15-71 (278) alignment 
Range on Protein: 1338-1403
Range on HMM: 15-71/278.0
KSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVlttkrdsDYINACFVDGYarKNCYIAAQG
  ... .   .|..  . |..|||. .|.||| .||.       ||||| ..|||  .. .||.||
fllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqg
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1309-1400 1.7e-13 45.3 In-house 6-96 (297) alignment 
Range on Protein: 1309-1400
Range on HMM: 6-96/297.0
EFKPIHVSVFHSHVLEmhSNSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTK---RDSDYINACFVDGYARknCYIA
| .|| .| | . | .  . . . | .||. .| .   | ||     |..|.|. || |||  || |       ||||.|| || |.     .|.
errpiplsdfatlvqk..nrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlit
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1312-1403 1.9e-13 44.6 In-house 3-95 (392) alignment 
Range on Protein: 1312-1403
Range on HMM: 3-95/392.0
PIHVSVFHSHVLEMhsNSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQG
|| |. | . | .        | .||. .|     | ||.  | |..|||. ||.|||..||.|       ||||.|| .....  ...|||.||
pipvaqfpafvekn..rhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqg
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1312-1403 2.9e-13 44.3 In-house 2-94 (315) alignment 
Range on Protein: 1312-1403
Range on HMM: 2-94/315.0
PIHVSVFHSHVLEmhSNSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQG
|| |. | . | .        | .||. .|     . .|.  . | .|||. ||.|.| .||.|     . ||||||| .. ..   ..|||.||
pipvaqfpafvnk..nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqg
subfamily_PTPN12_pd Subfamily PTPN12 1329-1403 3.4e-13 44.1 In-house 6-90 (290) alignment 
Range on Protein: 1329-1403
Range on HMM: 6-90/290.0
SDQEFDNEFKSIPMTSG-------APYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQG
...|| .||... ..|         . ..|..| |. |||. .|.||| .||.|....   .|||||| |. | . |  ||||||
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqg
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1345-1403 3.4e-13 44.7 In-house 14-75 (284) alignment 
Range on Protein: 1345-1403
Range on HMM: 14-75/284.0
GAPYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQG
|.  |    . |  |||. .|...| ..| |     .  |||||| |. || ||. |||.||
gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqG
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1350-1403 5.5e-13 43.7 In-house 3-59 (250) alignment 
Range on Protein: 1350-1403
Range on HMM: 3-59/250.0
VGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQG
|.   .|  |||. .| ..| .|||| ...   .|||||| |..||  .. .||.||
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqg
0040439 (Phosphotyrosine protein) phosphatases II 1347-1403 6.3e-13 44.4 In-house 2-61 (249) alignment 
Range on Protein: 1347-1403
Range on HMM: 2-61/249.0
PYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQG
.|.|.. ..|..|||. .|.||| .||.|.  ..   |||||| ..||| .|. .||.||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqg
subfamily_PTPN9_pd Subfamily PTPN9 1348-1403 1e-12 42.7 In-house 34-92 (297) alignment 
Range on Protein: 1348-1403
Range on HMM: 34-92/297.0
YTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQG
...  . ||. |||. ..  || |||||...     |||||| ||||| .|...||.||
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqG
0042113 (Phosphotyrosine protein) phosphatases II 1349-1403 1e-12 43.5 In-house 2-59 (245) alignment 
Range on Protein: 1349-1403
Range on HMM: 2-59/245.0
TVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQG
.|.. ..|..|||. .|.||| |||.|.      |||||||..|||| ... .||.||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqg
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1321-1403 1.3e-12 42.0 In-house 8-92 (301) alignment 
Range on Protein: 1321-1403
Range on HMM: 8-92/301.0
HVLEMHSNSdqeFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD-----SDYINACFVDGYARKNCYIAAQG
||  .|||.   |....|..  ..  . ||| ||.| . ||| || .||  |..|..|..      .|||| ..||| .|. .|||||
hvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqg
subfamily_PTPRK_pd Subfamily PTPRK 1318-1403 2.7e-12 41.1 In-house 9-93 (314) alignment 
Range on Protein: 1318-1403
Range on HMM: 9-93/314.0
FHSHVLEMHSNSDQEFDNEFKSIPMTsgapYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR-D--SDYINACFVDGYARKNCYIAAQG
   ..  .. .    | .|..|..      . .   . |  |||. .| .|| .||.|.|   |  |||||| ..|.| | . .|..||
llqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqg
Y_phosphatase Protein-tyrosine phosphatase 1356-1403 4.9e-12 41.1 Pfam-A 1-49 (235) alignment 
Range on Protein: 1356-1403
Range on HMM: 1-49/235.0
NIPKNRFLNIFPYDATRVVL-TTKRDSDYINACFVDGYARKNCYIAAQG
|  |||. .| ||| ||| |  .. .|||||| .|.|| .|. .||.||
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQg
Y_phosphatase Protein-tyrosine phosphatase 1356-1403 4.9e-12 41.1 In-house 1-49 (235) alignment 
Range on Protein: 1356-1403
Range on HMM: 1-49/235.0
NIPKNRFLNIFPYDATRVVL-TTKRDSDYINACFVDGYARKNCYIAAQG
|  |||. .| ||| ||| |  .. .|||||| .|.|| .|. .||.||
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQg
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1333-1403 6.6e-12 39.8 In-house 12-87 (287) alignment 
Range on Protein: 1333-1403
Range on HMM: 12-87/287.0
FDNEFKSIP---MTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVL--TTKRDSDYINACFVDGYARKNCYIAAQG
 |.|.. .     .| | .      |.. |||. ...|.| |||.|  ...  |||||| .| .| ... .|||||
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqg
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1328-1402 1.5e-11 38.8 In-house 3-78 (267) alignment 
Range on Protein: 1328-1402
Range on HMM: 3-78/267.0
NSDQEFDNEFKSIPMTSGAPYTVGS--SEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVDGYARKNCYIAAQ
....|...||. |   |    |.    .| |  .||. .  ||| |||.| || . .|||| .|.|| .|| .|. |
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkee.eyinasyvegyktknafivtq
subfamily_PTPN6_pd Subfamily PTPN6 1329-1403 1.6e-11 38.7 In-house 24-105 (306) alignment 
Range on Protein: 1329-1403
Range on HMM: 24-105/306.0
SDQEFDNEFKSIP---MTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVL--TTKRDSDYINACFVDGYAR--KNCYIAAQG
. . | .||...    ...    . |.   |  |||. ||.|.| |||.|      .|||||| .... ..  ...|||.||
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqg
fn3 Fibronectin type III domain 931-1006 3.5e-11 36.3 Pfam-A 7-83 (85) alignment 
Range on Protein: 931-1006
Range on HMM: 7-83/85.0
SVPSISDTAVNLTWRPPLYPNGRITGYNITNDNNGRS-YWIPIASVESVYSRIVTELNIGVLYNFTIRAFNELGGGE
|| ....| ..|.| ||  ..| ||||...  . | . .|  .   .. .| ..|.|. |  |.|...| |. |.|.
svsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 467-546 3.6e-11 36.2 Pfam-A 2-85 (85) alignment 
Range on Protein: 467-546
Range on HMM: 2-85/85.0
PVSTVTFASVSSISISVSWDEVPcdGQNGFITGYYLTYN---SG--IVNITGGDNR-TYIFRDLLPYTNYTVSIMPYNVVGMGPPS
... ... .|.| |...||.. .   ..| |||| ..|    .|   ...|   .  ......| |.|.|....  .| .| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_CG7180_pd Subfamily CG7180 1328-1402 3.9e-11 37.1 In-house 14-91 (296) alignment 
Range on Protein: 1328-1402
Range on HMM: 14-91/296.0
NSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
.   |.. |.| .|  .      |  . |. |||  .. ||| .||||..   . .|||||| .||.. .|. ||  .
kfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivte
subfamily_PTPN23_pd Subfamily PTPN23 1330-1403 9.2e-11 36.1 In-house 14-90 (288) alignment 
Range on Protein: 1330-1403
Range on HMM: 14-90/288.0
DQEFDNEFKSIPMTSGA---PYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVDGYA-RKNCYIAAQG
  ..|..|| . ..  .     ..  .. .  |||. .|.||| .||.|  ..| |||||.|| . .    ..||.|.
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskD.DYinAsfvkdlspgcPdfiatqa
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1317-1402 9.9e-11 35.7 In-house 6-97 (439) alignment 
Range on Protein: 1317-1402
Range on HMM: 6-97/439.0
VFHSHVLEMHSNSDQEFDNEFKSIPMTSGA---PYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
 |. || ... | .. |...|..|  ||       .. . | . .|||. .. ..| |||.|        | |||| ...||  .. |||.|
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatq
0037934 (Phosphotyrosine protein) phosphatases II 1348-1403 2e-10 36.1 In-house 2-51 (243) alignment 
Range on Protein: 1348-1403
Range on HMM: 2-51/243.0
YTVGSSEANIPKNRFLNIFPYDATRVVLttkRDSDYINACFVDGYarkNCYIAAQG
........|..|||. .|.||| .||.|    .|||||| .....   . .|| ||
fsiallpenlsknrysdilpydhsrvkl...egsdyinanliyvt...prliatqg
subfamily_PTPN3_pd Subfamily PTPN3 1352-1403 2.7e-10 34.7 In-house 37-91 (280) alignment 
Range on Protein: 1352-1403
Range on HMM: 37-91/280.0
SSEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVD----GYARKNCYIAAQG
   .|..|||. .| ||||||| |.  .  ||||| .|.    . .  | |||.||
rkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqG
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1331-1403 9.3e-10 33.0 In-house 5-80 (274) alignment 
Range on Protein: 1331-1403
Range on HMM: 5-80/274.0
QEFDNEFKSIPMTS-GAPYTVGSSEAnipKNRFLNIFPYDATRVVLTT----KRDSDYINACFVDGYAR-KNCYIAAQG
.....|| ..|.    . ..|  |.    |||. .|.| . .||.|..    . ||.|||| .. || . ...|.|.||
kdlekeflelPlnfdqeeldvfgsqt...knryktilPnensrvllesessededssyinanyikGydeeskayvatqG
subfamily_PTPN14_pd Subfamily PTPN14 1322-1403 5.7e-09 30.4 In-house 15-100 (300) alignment 
Range on Protein: 1322-1403
Range on HMM: 15-100/300.0
VLEMHSNSDQEFdNEFKSIP-MTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD--SDYINACFVDGY--ARKNCYIAAQG
.||.. .. . |  |.  || .   | ..... . | .|||| .. ||. .|| |.. ..  ..||||  .     ...  ||.|||
ilekkleegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqg
Ig_2 Immunoglobulin domain 753-837 1.3e-08 26.8 Pfam-A 12-78 (80) alignment 
Range on Protein: 753-837
Range on HMM: 12-78/80.0
SVGESYNMTCIVSvldlLIPSTEIQWSKtlPNDTLPSLSNGettsiHYIKSLNTSDAGQYTCTATISLTdieieaqSIDSHTITL
. ||. ..|| ..      | ...||.|   ...|..  |.      .|.... .|.|.|||.|. | .       |. | ....
tegenvtLtCqap....gnptpkvqwyk..dgeelsqsqna.....lfipnvsaedsGtYtCrasnseg.......skqsnsvev
subfamily_PTPN13_pd Subfamily PTPN13 1344-1403 1.3e-08 29.4 In-house 25-84 (273) alignment 
Range on Protein: 1344-1403
Range on HMM: 25-84/273.0
SGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDsdYINACFVDGYARKNC--YIAAQG
.    .|| ...|  |||. |..|||.||| |  .    |||| ..     |.   |||.||
pldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqG
subfamily_PTPRN_pd Subfamily PTPRN 1323-1403 1.8e-08 28.4 In-house 21-107 (297) alignment 
Range on Protein: 1323-1403
Range on HMM: 21-107/297.0
LEMHSNSDQEFDNEFKSIPMTSGAPYTV--GSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFV-DGYARKNCYIAAQG
|| | .  . ...|....      | |   ...| |. |||  ...||| .|| |..   . .|||||| .. |   |. .|||.||
ledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqg
fn3 Fibronectin type III domain 651-731 2e-08 27.4 Pfam-A 1-84 (85) alignment 
Range on Protein: 651-731
Range on HMM: 1-84/85.0
SSVQGLMVIPLNASSVYVSWMTP--NISPISYYTLYYNESTDN--VFSVNLSNTSTHGVITGLtGSSTEHEFRISVTIGDFEGQL
|....| |.. ...|. .||  |  . .||..|.. | |....    ......|.|. ..|||   .|| |||.    |. ||. 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgL.kpgteYefrVqavngagegpe
subfamily_PTPN1_pd Subfamily PTPN1 1346-1403 5.8e-08 26.8 In-house 22-78 (290) alignment 
Range on Protein: 1346-1403
Range on HMM: 22-78/290.0
APYTVGSSEANIPKNRFLNIFPYDATRVVLTtKRDSDYINACFVDGYARKNCYIAAQG
 | ..   ..| ..||. .. ||| .|..|  . | ||||| .|.    |  || .||
fptreaklpenrnlnryrdvspydhsrikle.radndyinaslveleeakrsyiltqG
0049772 (Phosphotyrosine protein) phosphatases II 1342-1402 1.2e-07 27.3 In-house 32-90 (314) alignment 
Range on Protein: 1342-1402
Range on HMM: 32-90/314.0
MTSGAPYTVGSSEANIPKNRFLNIFPYDaTRVVLtT---KRDSDYINACFVDGYarkNCYIAAQ
...   ..|.. ..|. |||.|.|.|.| .||.|      ..|||||| .|||.   . .||.|
vlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatq
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1353-1403 1.2e-07 26.0 In-house 17-71 (270) alignment 
Range on Protein: 1353-1403
Range on HMM: 17-71/270.0
SEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARK-NCYIAAQG
   .   ||. .| |  ||||.| . .    . |||| .| |.  . . ||||.|
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamg
fn3 Fibronectin type III domain 1022-1100 1.6e-07 24.5 Pfam-A 1-73 (85) alignment 
Range on Protein: 1022-1100
Range on HMM: 1-73/85.0
SPPERVEATLShDKTTITISWDSKTfDEVGAFFAYKVTATTTSTRKrqsgSPIEMIVPYNTTSVSFTGVNPNLMYQITA
|.||.. ..     |..|.||.  . |  | .  |.|.  .... .     . |  || .|||| .|| .|.  |... 
saPenlsvsev.tstsltlsWsppk.dgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrV
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1328-1403 5.9e-07 23.7 In-house 6-82 (283) alignment 
Range on Protein: 1328-1403
Range on HMM: 6-82/283.0
NSDQEFDNEFKSIPMTSgAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVD---GYARKNCYIAAQG
|. . | . .| . . .  . .. |.. | .|||. .| |.|  || | ..   |||||.|.     | ... ||.||.
nnnklfrevlkrlsvpd.ldadiasadenkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1311-1393 6.7e-07 23.0 In-house 4-87 (440) alignment 
Range on Protein: 1311-1393
Range on HMM: 4-87/440.0
KPIHVSVFHSHVLEmhSNSDQEFDNEFKSIPMTSGAPYTVGSSEANIPKNRFLNIFPYDATRVVLTTK---RDSDYINACFVDGYA
.|| |. |  .| .  .   . |..|.  .|     |  . |   |  |||. ||. || .||.|       ||||||| ...|  
rpiivadfadyvqn..nrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1354-1392 6.8e-07 23.2 In-house 37-77 (244) alignment 
Range on Protein: 1354-1392
Range on HMM: 37-77/244.0
EANIPKNRFLNIFPYDATRVVLTT--KRDSDYINACFVDGY
 ||  |||..||.|.| |||.|..  |  |||||| ...| 
sanatknryinilpfdetrvilssskkegsdyinanyiqgs
subfamily_ptpA1_pd Subfamily ptpA1 1331-1403 1.2e-06 22.5 In-house 21-96 (418) alignment 
Range on Protein: 1331-1403
Range on HMM: 21-96/418.0
QEFDNEFKSIPMTSGAPYT-VGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKNcYIAAQG
..  .||. .  . |   |  |  . |  |||. ||.| . ||| |     |  |||||| ..||   |. .|..||
hkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqg
I-set Immunoglobulin I-set domain 748-824 1.5e-06 19.9 Pfam-A 8-83 (90) alignment 
Range on Protein: 748-824
Range on HMM: 8-83/90.0
ANGTQSVGESYNMTCIVSVLdlliPSTEIQWSKTlpNDTLPS-----LSNGETTSIHYIKSLNTSDAGQYTCTATISLTDIE
 . . |.||| ...| |.      |  ...| |   .  | |     ... | ..   |.. ..||.|.|||.|| |.   |
kdvevseGesvelectveGe....pepsvsWakd..gselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkae
0041856 (Phosphotyrosine protein) phosphatases II 1356-1403 1.5e-06 23.5 In-house 1-41 (182) alignment 
Range on Protein: 1356-1403
Range on HMM: 1-41/182.0
NIPKNRFLNIFPYDATRvvlttkrDSDYINACFVDGYARKNCYIAAQG
|..|||. .|.||| .|       |.||||| ...|. . . .||.||
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatqg
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1357-1403 3.3e-06 21.5 In-house 4-52 (237) alignment 
Range on Protein: 1357-1403
Range on HMM: 4-52/237.0
IPKNRFLNIFPYDATRVVLTT-KRDSDYINACFVDGYAR-KNCYIAAQG
  |||. ||  || .||||     .||||||....|.    . ||||||
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1347-1402 5.9e-06 20.0 In-house 25-81 (332) alignment 
Range on Protein: 1347-1402
Range on HMM: 25-81/332.0
PYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR-DSDYINACFVDGYARKNCYIAAQ
| |      |.  ||   .. .| .|| |. .    |. || .||||..|..|| ||
pntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaq
fn3 Fibronectin type III domain 370-435 8e-06 19.1 Pfam-A 2-67 (85) alignment 
Range on Protein: 370-435
Range on HMM: 2-67/85.0
EVTDLIATNITSTSFNLSWSPPA-NIFPPNNFNIQFechRLCELSS-SIATQASVSS-PYVVNDIAPYS
....| ....||||..||||||. .  |  ......   | .. .. .   ... ..  ...... |..
aPenlsvsevtstsltlsWsppkdgggpitgYevey...rekgggeewkeftvprtttsvtltgLkpgt