Gene PTPRD-36 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP091_AA protein Get Run
AqueP091_AA_835-922 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 829-922 1.7e-66 214.4 In-house 1-94 (95) alignment 
Range on Protein: 829-922
Range on HMM: 1-94/95.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDSDYINACFVDGYARKNCYIAAQ
||||||||||||||||||||||||||||||||.|||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
efkpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq
subfamily_PTPRD_pd Subfamily PTPRD 831-922 3.1e-29 97.0 In-house 3-97 (564) alignment 
Range on Protein: 831-922
Range on HMM: 3-97/564.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKNCYIAAQ
|||.|. ...|| ....|||..|..|.|.| . .    .. . .|| .|||. || .||..||||.    . .|||||| |.||| ... |||.|
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 831-922 1.9e-21 71.5 In-house 3-97 (319) alignment 
Range on Protein: 831-922
Range on HMM: 3-97/319.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
..|.|  ..... ...|.... ...||| . ...   ..  | | | .|||. || .|| |||||..   . .|||||| |.||| ... .||.|
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 833-922 3.5e-21 70.6 In-house 2-95 (318) alignment 
Range on Protein: 833-922
Range on HMM: 2-95/318.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSI-PMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTK---RDSDYINACFVDGYARKNCYIAAQ
|.|. ..||| ..... . ....|.. . . .. .. .   ...|  |||. || .|| ||| |...    .|||||| ..||| ||. |||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 831-922 2.8e-20 67.7 In-house 2-95 (305) alignment 
Range on Protein: 831-922
Range on HMM: 2-95/305.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTsGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDS---DYINACFVDGYARKNCYIAAQ
|.| .. ..... |....||.......||.... . .. ||..|||  |||. .|...|  |. ||.| .    |||||..|||| ||..||.||
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaq
subfamily_PTPRG_pd Subfamily PTPRG 833-922 6.2e-20 65.9 In-house 1-97 (563) alignment 
Range on Protein: 833-922
Range on HMM: 1-97/563.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGA---AYTVGSSEANIPKNRFLNIFPYDATRVVLTT----KRDSDYINACFVDGYARKNCYIAAQ
..|. |..|| ..|...|. |..||... ... .    ..  . . |  ||| ||| .|| .|| |.     |.. ||||| ..||| ... .||.|
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatq
0051299 (Phosphotyrosine protein) phosphatases II 832-922 2.4e-19 65.3 In-house 4-98 (288) alignment 
Range on Protein: 832-922
Range on HMM: 4-98/288.0
PIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTS-GAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQ
.|.|. ....||... |.   . .||. ..       ..... ..|..|||. .|.||| .||.|..  .   |||||| ..||| .|. .||.|
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatq
subfamily_PTPRB_pd Subfamily PTPRB 829-922 3.2e-19 64.1 In-house 3-100 (293) alignment 
Range on Protein: 829-922
Range on HMM: 3-100/293.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMT-SGAAYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
. |||... |..|| .|...|| .| .|....    .  | .. ....|  |||. || |||..|| |   .....|||||| ...||  .. .||.|
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatq
subfamily_PTPRA_pd Subfamily PTPRA 829-922 4.8e-19 63.4 In-house 10-107 (330) alignment 
Range on Protein: 829-922
Range on HMM: 10-107/330.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPM-TSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
.. |. |  .   .    ..  . | .||...|  .  |.. . | | |  |||..||.||| .||.|..|.   .|||||| |.||| .|. .||||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaq
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 832-922 5.1e-19 63.4 In-house 3-96 (288) alignment 
Range on Protein: 832-922
Range on HMM: 3-96/288.0
PIHVSVFhSHVLEMHSNSDQEFDNEFKSI-PMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
|||.|   ..| ... .. ..| .|..|. .. .  . |.|.   | .|||. || ||| .|| |.    ....||||| ..||. .|. |||.|
pihispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatq
0040438 (Phosphotyrosine protein) phosphatases II 839-922 1.6e-18 62.5 In-house 6-92 (317) alignment 
Range on Protein: 839-922
Range on HMM: 6-92/317.0
HSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQ
. ..| .. .. . . .||. ..  .   |.|.. ..|..|||. .|.|||..||.|.       |||||| .|||. .|. .||.|
llalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatq
0039614 (Phosphotyrosine protein) phosphatases II 829-922 4.7e-18 61.1 In-house 10-107 (297) alignment 
Range on Protein: 829-922
Range on HMM: 10-107/297.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAaYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD----SDYINACFVDGYAR-KNCYIAAQ
|. ||..||.. ..| .. || . ...||....      |... ...|..|||. .|.||| .||.|.....    |||||| .|||| . .. .||.|
esipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq
0050432 (Phosphotyrosine protein) phosphatases II 831-922 5.4e-18 60.8 In-house 22-114 (308) alignment 
Range on Protein: 831-922
Range on HMM: 22-114/308.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSG-AAYTVGSSEANIPKNRFLNIFPYDATRVVLttKRDSDYINACFVDGY--ARKNCYIAAQ
. ...|| . . | .. .. . .. ||. ....     |.|.. ..|..|||. .|.||| .||.|  . .|||||| .||||   ... .||.|
sslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatq
0043336 (Phosphotyrosine protein) phosphatases II 833-922 8.6e-17 57.0 In-house 2-94 (278) alignment 
Range on Protein: 833-922
Range on HMM: 2-94/278.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
|.|. .. ..||.. |. . . .||....      |... ...|..|||. .|.||| .||.|.      ||||||| .|||| ... .||.|
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatq
0045450 (Phosphotyrosine protein) phosphatases II 828-922 1.1e-16 56.9 In-house 4-113 (307) alignment 
Range on Protein: 828-922
Range on HMM: 4-113/307.0
NEFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSG---AAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD----SDYINACFV--------DGY
.  ..| . .. ..||... .. . .  ||....         |.......|..|||. .|.||| |||.|..  .    |||||| .|        |||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

ARKNCYIAAQ
 .|. .||.|
dlkrkfIatq
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 844-922 1.3e-16 55.7 In-house 20-105 (298) alignment 
Range on Protein: 844-922
Range on HMM: 20-105/298.0
EMHSNSDQEFDNEFKSIPMTSG----AAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
 .....   ...||. .  .|     . ..|.....|  |||. .| ..| .||||..   . .|||||| |...| ..| .||.|
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq
0046845 (Phosphotyrosine protein) phosphatases II 853-922 2.2e-16 55.5 In-house 2-83 (284) alignment 
Range on Protein: 853-922
Range on HMM: 2-83/284.0
FDNEFKSIPMTSGA---AYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD----SDYINACFVDGY-----ARKNCYIAAQ
.. ||. ...        ..|.  ..|. |||. .|.||| .||.|..  .    |||||| .||||      .|. .||.|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatq
0047943 (Phosphotyrosine protein) phosphatases II 846-922 2.8e-16 55.2 In-house 7-83 (273) alignment 
Range on Protein: 846-922
Range on HMM: 7-83/273.0
HSNSDQEFDNEFKSIPMTS-GAAYTVGSSEANIPKNRFLNIFPYDATRVVLtTKRDSDYINACFVDGYARKNCYIAAQ
.... . .  ||. .. .     |.|.. ..|. |||. .|.||| .||.| .  .|||||| .|||| .|. .||.|
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatq
0036941 (Phosphotyrosine protein) phosphatases II 864-922 4.2e-16 54.6 In-house 27-84 (297) alignment 
Range on Protein: 864-922
Range on HMM: 27-84/297.0
SGAAYTVGSSEANIPKNRFLNIFPYDATRVVLtTKRDSDYINACFVDGYARKNCYIAAQ
    ..|.....|..|||. .|.||| |||.| .. .||||||..|||| .|. .||.|
llgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 836-922 5.3e-16 53.6 In-house 8-97 (325) alignment 
Range on Protein: 836-922
Range on HMM: 8-97/325.0
SVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQ
  .  || . ... .. | .||. .|   | |..|    .|. |||| |. ..| .|||| ||.|   |||||| ..  . .|. ..|||
vnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 833-922 5.4e-16 53.4 In-house 2-92 (287) alignment 
Range on Protein: 833-922
Range on HMM: 2-92/287.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPM--TSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTtKRDSDYINACFVDGYARKNCYIAAQ
| |. |   | . | .....| | |. .     .    |.. .. | .|||. .| ..|  ||.|  ... |||||.|.|||  |. .|.|.
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiae
subfamily_Ptp69D_pd Subfamily Ptp69D 832-922 1e-15 52.7 In-house 3-97 (307) alignment 
Range on Protein: 832-922
Range on HMM: 3-97/307.0
PIHVSVFHSHVLEMHSNSDQEFDNEFKSIP-MTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKNCYIAAQ
.|..   .. .   . ..|. . .|.....  ..    .|.  . |  |||. .| ..| |||.|.    | ||||||| |. ||  |. .||||
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaq
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 833-922 1.3e-15 52.1 In-house 2-97 (290) alignment 
Range on Protein: 833-922
Range on HMM: 2-97/290.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPMT-SGAAYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRD--SDYINACFVDGYARKNCYIAAQ
| |. |  .| . |.. .. | |.||..  . |  . ||| .. | ..||| || .||  |..|     ..|   .|||||...||  |. |||.|
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatq
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 840-922 1.6e-15 52.0 In-house 4-90 (281) alignment 
Range on Protein: 840-922
Range on HMM: 4-90/281.0
SHVLEMHSNSDQEFDNEFKSIPM-TSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKNCYIAAQ
 |. ....|... | .|....     . . |   ...|. |||. ||. ||||||..|   .. ..||||| ||.||  .. |||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatq
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 830-922 1.1e-14 49.1 In-house 3-98 (315) alignment 
Range on Protein: 830-922
Range on HMM: 3-98/315.0
FKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
..|| .  . ..| . .... . | ....|||        |     |  |||. || .|| .|| |    .. .|||.|| |.|||..|. |||||
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaq
DSPc_SM00195 853-922 8.3e-14 46.9 In-house 2-75 (263) alignment 
Range on Protein: 853-922
Range on HMM: 2-75/263.0
FDNEFKSIPMTS-GAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
...||... .       | .  ..|  |||. ||.||| ||| |...    .|||||| ...|. .|. |||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQ
PTPc_SM00194 853-922 8.3e-14 46.9 In-house 2-75 (263) alignment 
Range on Protein: 853-922
Range on HMM: 2-75/263.0
FDNEFKSIPMTS-GAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
...||... .       | .  ..|  |||. ||.||| ||| |...    .|||||| ...|. .|. |||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQ
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 850-922 1.8e-13 45.5 In-house 33-110 (319) alignment 
Range on Protein: 850-922
Range on HMM: 33-110/319.0
DQEFDNEFKSIPMT--SGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
 ...  ||. ..    ..|  |    . |  |||. ||...| ..| |     .  |||||| ||.|| ||. |||||
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaq
0045098 (Phosphotyrosine protein) phosphatases II 859-922 3e-13 45.3 In-house 16-70 (278) alignment 
Range on Protein: 859-922
Range on HMM: 16-70/278.0
SIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVlttkrdsDYINACFVDGYarKNCYIAAQ
 ... .   .|..  . |..|||. .|.||| .||.       ||||| ..|||  .. .||.|
llllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatq
AAA ATPase family associated with various cellular activities (AAA) 70-178 3.1e-13 38.5 Pfam-A 2-109 (132) alignment 
Range on Protein: 70-178
Range on HMM: 2-109/132.0
LIYGPKGTGKTTLAARVAVLGHFTYIKVvTASNMIGLTDFGKIEYIHQVFKDAFSSS-HSLIVLDDVHRLVEYVqVGDRVSVSHSLMHALSTLLSYSMSS
|.|||.|||||.||  ||   .......  .|...  .   . . |...||.| ... .| ...|....|..    |.  ... ... .| | |.   ..
llyGppGtGKTllakavakelgveflei.sgsellskyvgesekkirelfkeakekakpsilfiDEidalaksr.sgseseeeervvnqLlteldgvkkk

GSTVMVIGTM
 |.|.|||. 
eskvivigat
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 829-914 3.7e-13 44.3 In-house 6-92 (297) alignment 
Range on Protein: 829-914
Range on HMM: 6-92/297.0
EFKPIHVSVFHSHVLEmhSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTK---RDSDYINACFVDGYAR
| .|| .| | . | .  . . . | .||. .| .   . ||     |..|.|. || |||  || |       ||||.|| || |.  
errpiplsdfatlvqk..nrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh
fn3 Fibronectin type III domain 286-359 6.3e-13 41.9 Pfam-A 7-84 (85) alignment 
Range on Protein: 286-359
Range on HMM: 7-84/85.0
SANNIESDAVDLDWSPPNklLQNGQILSYSVSCSFVGNNS----FNTVNTT--LSISDLDPYTTYTCNVSAINVVGVGPA
|. .. |. . | ||||.   ..|.| .|.| .. .|...    |.. .||  . ...| |.|.|...| |.| .| ||.
svsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 870-922 8.9e-13 43.0 In-house 3-58 (250) alignment 
Range on Protein: 870-922
Range on HMM: 3-58/250.0
VGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
|.   .|  |||. .| ..| .|||| ...   .|||||| |..||  .. .||.|
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatq
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 832-922 1.1e-12 42.1 In-house 3-94 (392) alignment 
Range on Protein: 832-922
Range on HMM: 3-94/392.0
PIHVSVFHSHVLEMhsNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
|| |. | . | .        | .||. .|       ||.  | |..|||. ||.|||..||.|       ||||.|| .....  ...|||.|
pipvaqfpafvekn..rhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasq
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 864-922 1.1e-12 43.0 In-house 13-74 (284) alignment 
Range on Protein: 864-922
Range on HMM: 13-74/284.0
SGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
.|.  |    . |  |||. .|...| ..| |     .  |||||| |. || ||. |||.|
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 832-922 1.2e-12 42.4 In-house 2-93 (315) alignment 
Range on Protein: 832-922
Range on HMM: 2-93/315.0
PIHVSVFHSHVLEmhSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
|| |. | . | .        | .||. .|       .|.  . | .|||. ||.|.| .||.|     . ||||||| .. ..   ..|||.|
pipvaqfpafvnk..nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasq
subfamily_PTPN12_pd Subfamily PTPN12 848-922 1.2e-12 42.4 In-house 5-89 (290) alignment 
Range on Protein: 848-922
Range on HMM: 5-89/290.0
NSDQEFDNEFKSIPMTSGA-------AYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
....|| .||... ..| .         ..|..| |. |||. .|.||| .||.|....   .|||||| |. | . |  |||||
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 851-922 1.4e-12 41.5 In-house 18-92 (515) alignment 
Range on Protein: 851-922
Range on HMM: 18-92/515.0
QEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
  | .||. .|       ||   | | .|||. ||.||| .|| |     . .|||.|| .. ..   ..|||.|
tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasq
0042113 (Phosphotyrosine protein) phosphatases II 869-922 1.9e-12 42.6 In-house 2-58 (245) alignment 
Range on Protein: 869-922
Range on HMM: 2-58/245.0
TVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
.|.. ..|..|||. .|.||| |||.|.      |||||||..|||| ... .||.|
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatq
subfamily_PTPN9_pd Subfamily PTPN9 855-922 2.1e-12 41.7 In-house 23-91 (297) alignment 
Range on Protein: 855-922
Range on HMM: 23-91/297.0
NEFKSIPMTsGAAyTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
 | .. |.. | . ..  . ||. |||. ..  || |||||...     |||||| ||||| .|...||.|
aeirnepve.Gtf.lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatq
0040439 (Phosphotyrosine protein) phosphatases II 868-922 2.4e-12 42.5 In-house 3-60 (249) alignment 
Range on Protein: 868-922
Range on HMM: 3-60/249.0
YTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQ
|.|.. ..|..|||. .|.||| .||.|.  ..   |||||| ..||| .|. .||.|
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatq
subfamily_PTPRK_pd Subfamily PTPRK 838-922 3.3e-12 40.9 In-house 9-92 (314) alignment 
Range on Protein: 838-922
Range on HMM: 9-92/314.0
FHSHVLEMHSNSDQEFDNEFKSIPMTsgaaYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR-D--SDYINACFVDGYARKNCYIAAQ
   ..  .. .    | .|..|..      . .   . |  |||. .| .|| .||.|.|   |  |||||| ..|.| | . .|..|
llqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtq
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 841-922 6.1e-12 39.8 In-house 8-91 (301) alignment 
Range on Protein: 841-922
Range on HMM: 8-91/301.0
HVLEMHSNSdqeFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD-----SDYINACFVDGYARKNCYIAAQ
||  .|||.   |....|..  ..    ||| ||.| . ||| || .||  |..|..|..      .|||| ..||| .|. .||||
hvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 848-922 6.6e-12 40.0 In-house 3-78 (267) alignment 
Range on Protein: 848-922
Range on HMM: 3-78/267.0
NSDQEFDNEFKSIPMTSGAAYTVGS--SEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVDGYARKNCYIAAQ
....|...||. |   |    |.    .| |  .||. .  ||| |||.| || . .|||| .|.|| .|| .|. |
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkee.eyinasyvegyktknafivtq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 849-922 6.9e-12 39.7 In-house 12-86 (287) alignment 
Range on Protein: 849-922
Range on HMM: 12-86/287.0
SDQEFDNEFKSIpMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL--TTKRDSDYINACFVDGYARKNCYIAAQ
 |.|.|.  .    .| | .      |.. |||. ...|.| |||.|  ...  |||||| .| .| ... .||||
vdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaq
Y_phosphatase Protein-tyrosine phosphatase 876-922 1.2e-11 39.9 Pfam-A 1-48 (235) alignment 
Range on Protein: 876-922
Range on HMM: 1-48/235.0
NIPKNRFLNIFPYDATRVVL-TTKRDSDYINACFVDGYARKNCYIAAQ
|  |||. .| ||| ||| |  .. .|||||| .|.|| .|. .||.|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQ
Y_phosphatase Protein-tyrosine phosphatase 876-922 1.2e-11 39.9 In-house 1-48 (235) alignment 
Range on Protein: 876-922
Range on HMM: 1-48/235.0
NIPKNRFLNIFPYDATRVVL-TTKRDSDYINACFVDGYARKNCYIAAQ
|  |||. .| ||| ||| |  .. .|||||| .|.|| .|. .||.|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQ
subfamily_CG7180_pd Subfamily CG7180 848-921 2.2e-11 37.9 In-house 14-90 (296) alignment 
Range on Protein: 848-921
Range on HMM: 14-90/296.0
NSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAA
.   |.. |.| .|  .      |  . |. |||  .. ||| .||||..   . .|||||| .||.. .|. ||  
kfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivt
subfamily_PTPN6_pd Subfamily PTPN6 847-922 3.9e-11 37.5 In-house 22-104 (306) alignment 
Range on Protein: 847-922
Range on HMM: 22-104/306.0
SNSDQEFDNEFKSIPM---TSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL--TTKRDSDYINACFVDGYAR--KNCYIAAQ
| . . | .||...     ..    . |.   |  |||. ||.|.| |||.|      .|||||| .... ..  ...|||.|
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatq
fn3 Fibronectin type III domain 472-545 4.4e-11 36.0 Pfam-A 9-83 (85) alignment 
Range on Protein: 472-545
Range on HMM: 9-83/85.0
PSISDTAVNLTWRPPLYPNGRITGYNITNDNNGRS-YWIPITSVELVYSRIVTELSIGMLYNFTIRAFNELGGGE
 ....| ..|.| ||  ..| ||||...  . | . .|  .|  .  .| ..|.|  |. |.|...| |. |.|.
sevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 837-922 7.1e-11 36.2 In-house 6-97 (439) alignment 
Range on Protein: 837-922
Range on HMM: 6-97/439.0
VFHSHVLEMHSNSDQEFDNEFKSIPMTSGA---AYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
 |. || ... | .. |...|..|  ||       .. . | . .|||. .. ..| |||.|        | |||| ...||  .. |||.|
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatq
subfamily_PTPN23_pd Subfamily PTPN23 848-922 9.5e-11 36.0 In-house 12-89 (288) alignment 
Range on Protein: 848-922
Range on HMM: 12-89/288.0
NSDQEFDNEFKSIPMTSGA---AYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVDGYA-RKNCYIAAQ
.   ..|..|| . ..  .     ..  .. .  |||. .|.||| .||.|  ..| |||||.|| . .    ..||.|
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskD.DYinAsfvkdlspgcPdfiatq
subfamily_PTPN3_pd Subfamily PTPN3 867-922 4.4e-10 33.9 In-house 32-90 (280) alignment 
Range on Protein: 867-922
Range on HMM: 32-90/280.0
AYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVD----GYARKNCYIAAQ
| ..    .|..|||. .| ||||||| |.  .  ||||| .|.    . .  | |||.|
aisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatq
0037934 (Phosphotyrosine protein) phosphatases II 869-922 8.4e-10 34.1 In-house 3-50 (243) alignment 
Range on Protein: 869-922
Range on HMM: 3-50/243.0
TVGSSEANIPKNRFLNIFPYDATRVVLttkRDSDYINACFVDGYarKNcYIAAQ
.......|..|||. .|.||| .||.|    .|||||| .....  .. .|| |
siallpenlsknrysdilpydhsrvkl...egsdyinanliyvt..pr.liatq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 851-922 3.7e-09 31.1 In-house 5-79 (274) alignment 
Range on Protein: 851-922
Range on HMM: 5-79/274.0
QEFDNEFKSIPMTS-GAAYTVGSSEAnipKNRFLNIFPYDATRVVLTT----KRDSDYINACFVDGYAR-KNCYIAAQ
.....|| ..|.    . ..|  |.    |||. .|.| . .||.|..    . ||.|||| .. || . ...|.|.|
kdlekeflelPlnfdqeeldvfgsqt...knryktilPnensrvllesessededssyinanyikGydeeskayvatq
subfamily_PTPN14_pd Subfamily PTPN14 842-922 5e-09 30.6 In-house 15-99 (300) alignment 
Range on Protein: 842-922
Range on HMM: 15-99/300.0
VLEMHSNSDQEFdNEFKSIP-MTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD--SDYINACFVDGY--ARKNCYIAAQ
.||.. .. . |  |.  || .   | ..... . | .|||| .. ||. .|| |.. ..  ..||||  .     ...  ||.||
ilekkleegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaq
subfamily_PTPN13_pd Subfamily PTPN13 854-918 1.3e-08 29.5 In-house 14-77 (273) alignment 
Range on Protein: 854-918
Range on HMM: 14-77/273.0
DNEFKSIP-MTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDsdYINACFVDGYARKNCY
..||| .  . .    .|| ...|  |||. |..|||.||| |  .    |||| ..     |. |
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdey
fn3 Fibronectin type III domain 561-639 4.4e-08 26.3 Pfam-A 1-73 (85) alignment 
Range on Protein: 561-639
Range on HMM: 1-73/85.0
SPPERVEATLShDKTTITVSWDSKTfDEVGAFFAYKVTATTTSTRKrqsgSPIEMIVPYNTTSVSFTGVNPNLMYQITA
|.||.. ..     |..|.||.  . |  | .  |.|.  .... .     . |  || .|||| .|| .|.  |... 
saPenlsvsev.tstsltlsWsppk.dgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrV
subfamily_PTPRN_pd Subfamily PTPRN 844-922 5.3e-08 26.9 In-house 22-106 (297) alignment 
Range on Protein: 844-922
Range on HMM: 22-106/297.0
EMHSNSDQEFDNEFKSIPMTSG--AAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFV-DGYARKNCYIAAQ
| | .  . ...|....       .. .|...| |. |||  ...||| .|| |..   . .|||||| .. |   |. .|||.|
edhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatq
AAA_14 AAA domain 70-147 6.1e-08 19.1 Pfam-A 6-82 (128) alignment 
Range on Protein: 70-147
Range on HMM: 6-82/128.0
LIYGPKGTGKTTLAARVA--VL--GHFTYIKVVTASNmIGLTDFGkieyIHQVFKDAFSSSHSLIVLDDVHRLVEYVQVGDR
.|.||...|||||. ...   |   .. ||.. ....   |.|.     ....|.. ... .....|| .... |  ..  .
vitGpRrvGKttllkqlikellkeenilyinlddeel.ekladpe....llelfleklkekkkylflDEiqkvpewedalks
fn3 Fibronectin type III domain 375-457 1.5e-07 24.6 Pfam-A 3-83 (85) alignment 
Range on Protein: 375-457
Range on HMM: 3-83/85.0
PQNFI--SIpNKTFISFRWTAPEIPNGVIIIYNLTVTNLDTASttvYIINVTDSNEIIESLITGFSPYQNYTASVSASTIIGAGP
|.|.   .. . | ....|..|. ..| |  |.... . .. .   .  ..| ..   .  .||  |...|. .| | .  | ||
Penlsvsev.tstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
0049772 (Phosphotyrosine protein) phosphatases II 864-922 1.8e-07 26.7 In-house 34-90 (314) alignment 
Range on Protein: 864-922
Range on HMM: 34-90/314.0
SGAAYTVGSSEANIPKNRFLNIFPYDaTRVVLtT---KRDSDYINACFVDGYarkNCYIAAQ
.   ..|.. ..|. |||.|.|.|.| .||.|      ..|||||| .|||.   . .||.|
peltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatq
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 874-922 2.7e-07 24.8 In-house 18-70 (270) alignment 
Range on Protein: 874-922
Range on HMM: 18-70/270.0
EANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARK-NCYIAAQ
  .   ||. .| |  ||||.| . .    . |||| .| |.  . . ||||.
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaam
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 872-912 3e-07 24.3 In-house 35-77 (244) alignment 
Range on Protein: 872-912
Range on HMM: 35-77/244.0
SSEANIPKNRFLNIFPYDATRVVLTT--KRDSDYINACFVDGY
   ||  |||..||.|.| |||.|..  |  |||||| ...| 
vlsanatknryinilpfdetrvilssskkegsdyinanyiqgs
AAA_5 AAA domain (dynein-related subfamily) 70-139 3.3e-07 16.6 Pfam-A 3-78 (139) alignment 
Range on Protein: 70-139
Range on HMM: 3-78/139.0
LIYGPKGTGKTTLAARVAVLGHFTYIKV-----VTASNMIGLTDF--GKIEYIHQVFKDAFSsSHSLIVLDDVHRLV
|. ||.||||..|| |.| .   ..  |      |.....| ...  |. ..  .....|.  . . .|||.|.|. 
lLvGppGtgKselaerlaealnreveyvqltrdtteedlkgrreiangttslvdsplvraar.egeilvlDEverae
subfamily_PTPN1_pd Subfamily PTPN1 868-922 3.5e-07 24.2 In-house 24-77 (290) alignment 
Range on Protein: 868-922
Range on HMM: 24-77/290.0
YTVGSSEANIPKNRFLNIFPYDATRVVLTtKRDSDYINACFVDGYARKNCYIAAQ
 ..   ..| ..||. .. ||| .|..|  . | ||||| .|.    |  || .|
treaklpenrnlnryrdvspydhsrikle.radndyinaslveleeakrsyiltq
AAA_24 AAA domain 66-85 6.8e-07 15.4 Pfam-A 3-22 (213) alignment 
Range on Protein: 66-85
Range on HMM: 3-22/213.0
MITSLIYGPKGTGKTTLAAR
 |. ||||. |.|||.||..
kikvliYGkpGiGKTslakt
subfamily_ptpA1_pd Subfamily ptpA1 846-916 1e-06 22.8 In-house 16-90 (418) alignment 
Range on Protein: 846-916
Range on HMM: 16-90/418.0
HSNSDQEFDNEFKSIPMTSGAAYT-VGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKN
| .  ..  .||. .  . | . |  |  . |  |||. ||.| . ||| |     |  |||||| ..||   |.
hikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 848-922 1.3e-06 22.5 In-house 6-81 (283) alignment 
Range on Protein: 848-922
Range on HMM: 6-81/283.0
NSDQEFDNEFKSIPMTSGAAyTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVD---GYARKNCYIAAQ
|. . | . .| . . .  | .. |.. | .|||. .| |.|  || | ..   |||||.|.     | ... ||.||
nnnklfrevlkrlsvpdlda.diasadenkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaq
0041856 (Phosphotyrosine protein) phosphatases II 876-922 3.2e-06 22.3 In-house 1-40 (182) alignment 
Range on Protein: 876-922
Range on HMM: 1-40/182.0
NIPKNRFLNIFPYDATRvvlttkrDSDYINACFVDGYARKNCYIAAQ
|..|||. .|.||| .|       |.||||| ...|. . . .||.|
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 831-913 3.9e-06 20.5 In-house 4-87 (440) alignment 
Range on Protein: 831-913
Range on HMM: 4-87/440.0
KPIHVSVFHSHVLEmhSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTK---RDSDYINACFVDGYA
.|| |. |  .| .  .   . |..|.  .|        . |   |  |||. ||. || .||.|       ||||||| ...|  
rpiivadfadyvqn..nrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 857-922 7e-06 19.7 In-house 17-81 (332) alignment 
Range on Protein: 857-922
Range on HMM: 17-81/332.0
FKSIPMTSGAAYTvgSSEANIPKNRFLNIFPYDATRVVLTTKR-DSDYINACFVDGYARKNCYIAAQ
...  ||   .|       |.  ||   .. .| .|| |. .    |. || .||||..|..|| ||
mhtsamtypntyd..kflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaq