Gene PTPRD-36 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP091_AA protein Get Run
AqueP091_AA_835-922 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 829-922 1.7e-66 214.4 In-house 1-94 (95) alignment
Range on Protein: 829-922
Range on HMM: 1-94/95.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDSDYINACFVDGYARKNCYIAAQ
||||||||||||||||||||||||||||||||.|||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
efkpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq

subfamily_PTPRD_pd Subfamily PTPRD 831-922 3.1e-29 97.0 In-house 3-97 (564) alignment
Range on Protein: 831-922
Range on HMM: 3-97/564.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKNCYIAAQ
|||.|. ...|| ....|||..|..|.|.| . .    .. . .|| .|||. || .||..||||.    . .|||||| |.||| ... |||.|
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtq

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 831-922 1.9e-21 71.5 In-house 3-97 (319) alignment
Range on Protein: 831-922
Range on HMM: 3-97/319.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
..|.|  ..... ...|.... ...||| . ...   ..  | | | .|||. || .|| |||||..   . .|||||| |.||| ... .||.|
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatq

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 833-922 3.5e-21 70.6 In-house 2-95 (318) alignment
Range on Protein: 833-922
Range on HMM: 2-95/318.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSI-PMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTK---RDSDYINACFVDGYARKNCYIAAQ
|.|. ..||| ..... . ....|.. . . .. .. .   ...|  |||. || .|| ||| |...    .|||||| ..||| ||. |||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaq

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 831-922 2.8e-20 67.7 In-house 2-95 (305) alignment
Range on Protein: 831-922
Range on HMM: 2-95/305.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTsGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDS---DYINACFVDGYARKNCYIAAQ
|.| .. ..... |....||.......||.... . .. ||..|||  |||. .|...|  |. ||.| .    |||||..|||| ||..||.||
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaq

subfamily_PTPRG_pd Subfamily PTPRG 833-922 6.2e-20 65.9 In-house 1-97 (563) alignment
Range on Protein: 833-922
Range on HMM: 1-97/563.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGA---AYTVGSSEANIPKNRFLNIFPYDATRVVLTT----KRDSDYINACFVDGYARKNCYIAAQ
..|. |..|| ..|...|. |..||... ... .    ..  . . |  ||| ||| .|| .|| |.     |.. ||||| ..||| ... .||.|
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatq

0051299 (Phosphotyrosine protein) phosphatases II 832-922 2.4e-19 65.3 In-house 4-98 (288) alignment
Range on Protein: 832-922
Range on HMM: 4-98/288.0
PIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTS-GAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQ
.|.|. ....||... |.   . .||. ..       ..... ..|..|||. .|.||| .||.|..  .   |||||| ..||| .|. .||.|
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatq

subfamily_PTPRB_pd Subfamily PTPRB 829-922 3.2e-19 64.1 In-house 3-100 (293) alignment
Range on Protein: 829-922
Range on HMM: 3-100/293.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMT-SGAAYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
. |||... |..|| .|...|| .| .|....    .  | .. ....|  |||. || |||..|| |   .....|||||| ...||  .. .||.|
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatq

subfamily_PTPRA_pd Subfamily PTPRA 829-922 4.8e-19 63.4 In-house 10-107 (330) alignment
Range on Protein: 829-922
Range on HMM: 10-107/330.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPM-TSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
.. |. |  .   .    ..  . | .||...|  .  |.. . | | |  |||..||.||| .||.|..|.   .|||||| |.||| .|. .||||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaq

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 832-922 5.1e-19 63.4 In-house 3-96 (288) alignment
Range on Protein: 832-922
Range on HMM: 3-96/288.0
PIHVSVFhSHVLEMHSNSDQEFDNEFKSI-PMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
|||.|   ..| ... .. ..| .|..|. .. .  . |.|.   | .|||. || ||| .|| |.    ....||||| ..||. .|. |||.|
pihispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatq

0040438 (Phosphotyrosine protein) phosphatases II 839-922 1.6e-18 62.5 In-house 6-92 (317) alignment
Range on Protein: 839-922
Range on HMM: 6-92/317.0
HSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQ
. ..| .. .. . . .||. ..  .   |.|.. ..|..|||. .|.|||..||.|.       |||||| .|||. .|. .||.|
llalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatq

0039614 (Phosphotyrosine protein) phosphatases II 829-922 4.7e-18 61.1 In-house 10-107 (297) alignment
Range on Protein: 829-922
Range on HMM: 10-107/297.0
EFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAaYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD----SDYINACFVDGYAR-KNCYIAAQ
|. ||..||.. ..| .. || . ...||....      |... ...|..|||. .|.||| .||.|.....    |||||| .|||| . .. .||.|
esipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

0050432 (Phosphotyrosine protein) phosphatases II 831-922 5.4e-18 60.8 In-house 22-114 (308) alignment
Range on Protein: 831-922
Range on HMM: 22-114/308.0
KPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSG-AAYTVGSSEANIPKNRFLNIFPYDATRVVLttKRDSDYINACFVDGY--ARKNCYIAAQ
. ...|| . . | .. .. . .. ||. ....     |.|.. ..|..|||. .|.||| .||.|  . .|||||| .||||   ... .||.|
sslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatq

0043336 (Phosphotyrosine protein) phosphatases II 833-922 8.6e-17 57.0 In-house 2-94 (278) alignment
Range on Protein: 833-922
Range on HMM: 2-94/278.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
|.|. .. ..||.. |. . . .||....      |... ...|..|||. .|.||| .||.|.      ||||||| .|||| ... .||.|
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatq

0045450 (Phosphotyrosine protein) phosphatases II 828-922 1.1e-16 56.9 In-house 4-113 (307) alignment
Range on Protein: 828-922
Range on HMM: 4-113/307.0
NEFKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSG---AAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD----SDYINACFV--------DGY
.  ..| . .. ..||... .. . .  ||....         |.......|..|||. .|.||| |||.|..  .    |||||| .|        |||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

ARKNCYIAAQ
 .|. .||.|
dlkrkfIatq

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 844-922 1.3e-16 55.7 In-house 20-105 (298) alignment
Range on Protein: 844-922
Range on HMM: 20-105/298.0
EMHSNSDQEFDNEFKSIPMTSG----AAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
 .....   ...||. .  .|     . ..|.....|  |||. .| ..| .||||..   . .|||||| |...| ..| .||.|
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq

0046845 (Phosphotyrosine protein) phosphatases II 853-922 2.2e-16 55.5 In-house 2-83 (284) alignment
Range on Protein: 853-922
Range on HMM: 2-83/284.0
FDNEFKSIPMTSGA---AYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD----SDYINACFVDGY-----ARKNCYIAAQ
.. ||. ...        ..|.  ..|. |||. .|.||| .||.|..  .    |||||| .||||      .|. .||.|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatq

0047943 (Phosphotyrosine protein) phosphatases II 846-922 2.8e-16 55.2 In-house 7-83 (273) alignment
Range on Protein: 846-922
Range on HMM: 7-83/273.0
HSNSDQEFDNEFKSIPMTS-GAAYTVGSSEANIPKNRFLNIFPYDATRVVLtTKRDSDYINACFVDGYARKNCYIAAQ
.... . .  ||. .. .     |.|.. ..|. |||. .|.||| .||.| .  .|||||| .|||| .|. .||.|
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatq

0036941 (Phosphotyrosine protein) phosphatases II 864-922 4.2e-16 54.6 In-house 27-84 (297) alignment
Range on Protein: 864-922
Range on HMM: 27-84/297.0
SGAAYTVGSSEANIPKNRFLNIFPYDATRVVLtTKRDSDYINACFVDGYARKNCYIAAQ
    ..|.....|..|||. .|.||| |||.| .. .||||||..|||| .|. .||.|
llgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatq

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 836-922 5.3e-16 53.6 In-house 8-97 (325) alignment
Range on Protein: 836-922
Range on HMM: 8-97/325.0
SVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQ
  .  || . ... .. | .||. .|   | |..|    .|. |||| |. ..| .|||| ||.|   |||||| ..  . .|. ..|||
vnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaq

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 833-922 5.4e-16 53.4 In-house 2-92 (287) alignment
Range on Protein: 833-922
Range on HMM: 2-92/287.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPM--TSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTtKRDSDYINACFVDGYARKNCYIAAQ
| |. |   | . | .....| | |. .     .    |.. .. | .|||. .| ..|  ||.|  ... |||||.|.|||  |. .|.|.
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiae

subfamily_Ptp69D_pd Subfamily Ptp69D 832-922 1e-15 52.7 In-house 3-97 (307) alignment
Range on Protein: 832-922
Range on HMM: 3-97/307.0
PIHVSVFHSHVLEMHSNSDQEFDNEFKSIP-MTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKNCYIAAQ
.|..   .. .   . ..|. . .|.....  ..    .|.  . |  |||. .| ..| |||.|.    | ||||||| |. ||  |. .||||
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaq

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 833-922 1.3e-15 52.1 In-house 2-97 (290) alignment
Range on Protein: 833-922
Range on HMM: 2-97/290.0
IHVSVFHSHVLEMHSNSDQEFDNEFKSIPMT-SGAAYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRD--SDYINACFVDGYARKNCYIAAQ
| |. |  .| . |.. .. | |.||..  . |  . ||| .. | ..||| || .||  |..|     ..|   .|||||...||  |. |||.|
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatq

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 840-922 1.6e-15 52.0 In-house 4-90 (281) alignment
Range on Protein: 840-922
Range on HMM: 4-90/281.0
SHVLEMHSNSDQEFDNEFKSIPM-TSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKNCYIAAQ
 |. ....|... | .|....     . . |   ...|. |||. ||. ||||||..|   .. ..||||| ||.||  .. |||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatq

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 830-922 1.1e-14 49.1 In-house 3-98 (315) alignment
Range on Protein: 830-922
Range on HMM: 3-98/315.0
FKPIHVSVFHSHVLEMHSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
..|| .  . ..| . .... . | ....|||        |     |  |||. || .|| .|| |    .. .|||.|| |.|||..|. |||||
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaq

DSPc_SM00195 853-922 8.3e-14 46.9 In-house 2-75 (263) alignment
Range on Protein: 853-922
Range on HMM: 2-75/263.0
FDNEFKSIPMTS-GAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
...||... .       | .  ..|  |||. ||.||| ||| |...    .|||||| ...|. .|. |||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQ

PTPc_SM00194 853-922 8.3e-14 46.9 In-house 2-75 (263) alignment
Range on Protein: 853-922
Range on HMM: 2-75/263.0
FDNEFKSIPMTS-GAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
...||... .       | .  ..|  |||. ||.||| ||| |...    .|||||| ...|. .|. |||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQ

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 850-922 1.8e-13 45.5 In-house 33-110 (319) alignment
Range on Protein: 850-922
Range on HMM: 33-110/319.0
DQEFDNEFKSIPMT--SGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
 ...  ||. ..    ..|  |    . |  |||. ||...| ..| |     .  |||||| ||.|| ||. |||||
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaq

0045098 (Phosphotyrosine protein) phosphatases II 859-922 3e-13 45.3 In-house 16-70 (278) alignment
Range on Protein: 859-922
Range on HMM: 16-70/278.0
SIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVlttkrdsDYINACFVDGYarKNCYIAAQ
 ... .   .|..  . |..|||. .|.||| .||.       ||||| ..|||  .. .||.|
llllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatq

AAA ATPase family associated with various cellular activities (AAA) 70-178 3.1e-13 38.5 Pfam-A 2-109 (132) alignment
Range on Protein: 70-178
Range on HMM: 2-109/132.0
LIYGPKGTGKTTLAARVAVLGHFTYIKVvTASNMIGLTDFGKIEYIHQVFKDAFSSS-HSLIVLDDVHRLVEYVqVGDRVSVSHSLMHALSTLLSYSMSS
|.|||.|||||.||  ||   .......  .|...  .   . . |...||.| ... .| ...|....|..    |.  ... ... .| | |.   ..
llyGppGtGKTllakavakelgveflei.sgsellskyvgesekkirelfkeakekakpsilfiDEidalaksr.sgseseeeervvnqLlteldgvkkk

GSTVMVIGTM
 |.|.|||. 
eskvivigat

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 829-914 3.7e-13 44.3 In-house 6-92 (297) alignment
Range on Protein: 829-914
Range on HMM: 6-92/297.0
EFKPIHVSVFHSHVLEmhSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTK---RDSDYINACFVDGYAR
| .|| .| | . | .  . . . | .||. .| .   . ||     |..|.|. || |||  || |       ||||.|| || |.  
errpiplsdfatlvqk..nrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh

fn3 Fibronectin type III domain 286-359 6.3e-13 41.9 Pfam-A 7-84 (85) alignment
Range on Protein: 286-359
Range on HMM: 7-84/85.0
SANNIESDAVDLDWSPPNklLQNGQILSYSVSCSFVGNNS----FNTVNTT--LSISDLDPYTTYTCNVSAINVVGVGPA
|. .. |. . | ||||.   ..|.| .|.| .. .|...    |.. .||  . ...| |.|.|...| |.| .| ||.
svsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 870-922 8.9e-13 43.0 In-house 3-58 (250) alignment
Range on Protein: 870-922
Range on HMM: 3-58/250.0
VGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
|.   .|  |||. .| ..| .|||| ...   .|||||| |..||  .. .||.|
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatq

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 832-922 1.1e-12 42.1 In-house 3-94 (392) alignment
Range on Protein: 832-922
Range on HMM: 3-94/392.0
PIHVSVFHSHVLEMhsNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
|| |. | . | .        | .||. .|       ||.  | |..|||. ||.|||..||.|       ||||.|| .....  ...|||.|
pipvaqfpafvekn..rhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasq

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 864-922 1.1e-12 43.0 In-house 13-74 (284) alignment
Range on Protein: 864-922
Range on HMM: 13-74/284.0
SGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAAQ
.|.  |    . |  |||. .|...| ..| |     .  |||||| |. || ||. |||.|
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatq

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 832-922 1.2e-12 42.4 In-house 2-93 (315) alignment
Range on Protein: 832-922
Range on HMM: 2-93/315.0
PIHVSVFHSHVLEmhSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
|| |. | . | .        | .||. .|       .|.  . | .|||. ||.|.| .||.|     . ||||||| .. ..   ..|||.|
pipvaqfpafvnk..nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasq

subfamily_PTPN12_pd Subfamily PTPN12 848-922 1.2e-12 42.4 In-house 5-89 (290) alignment
Range on Protein: 848-922
Range on HMM: 5-89/290.0
NSDQEFDNEFKSIPMTSGA-------AYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
....|| .||... ..| .         ..|..| |. |||. .|.||| .||.|....   .|||||| |. | . |  |||||
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaq

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 851-922 1.4e-12 41.5 In-house 18-92 (515) alignment
Range on Protein: 851-922
Range on HMM: 18-92/515.0
QEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
  | .||. .|       ||   | | .|||. ||.||| .|| |     . .|||.|| .. ..   ..|||.|
tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasq

0042113 (Phosphotyrosine protein) phosphatases II 869-922 1.9e-12 42.6 In-house 2-58 (245) alignment
Range on Protein: 869-922
Range on HMM: 2-58/245.0
TVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
.|.. ..|..|||. .|.||| |||.|.      |||||||..|||| ... .||.|
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatq

subfamily_PTPN9_pd Subfamily PTPN9 855-922 2.1e-12 41.7 In-house 23-91 (297) alignment
Range on Protein: 855-922
Range on HMM: 23-91/297.0
NEFKSIPMTsGAAyTVGSSEANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARKNCYIAAQ
 | .. |.. | . ..  . ||. |||. ..  || |||||...     |||||| ||||| .|...||.|
aeirnepve.Gtf.lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatq

0040439 (Phosphotyrosine protein) phosphatases II 868-922 2.4e-12 42.5 In-house 3-60 (249) alignment
Range on Protein: 868-922
Range on HMM: 3-60/249.0
YTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD---SDYINACFVDGYARKNCYIAAQ
|.|.. ..|..|||. .|.||| .||.|.  ..   |||||| ..||| .|. .||.|
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatq

subfamily_PTPRK_pd Subfamily PTPRK 838-922 3.3e-12 40.9 In-house 9-92 (314) alignment
Range on Protein: 838-922
Range on HMM: 9-92/314.0
FHSHVLEMHSNSDQEFDNEFKSIPMTsgaaYTVGSSEANIPKNRFLNIFPYDATRVVLTTKR-D--SDYINACFVDGYARKNCYIAAQ
   ..  .. .    | .|..|..      . .   . |  |||. .| .|| .||.|.|   |  |||||| ..|.| | . .|..|
llqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtq

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 841-922 6.1e-12 39.8 In-house 8-91 (301) alignment
Range on Protein: 841-922
Range on HMM: 8-91/301.0
HVLEMHSNSdqeFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD-----SDYINACFVDGYARKNCYIAAQ
||  .|||.   |....|..  ..    ||| ||.| . ||| || .||  |..|..|..      .|||| ..||| .|. .||||
hvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaq

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 848-922 6.6e-12 40.0 In-house 3-78 (267) alignment
Range on Protein: 848-922
Range on HMM: 3-78/267.0
NSDQEFDNEFKSIPMTSGAAYTVGS--SEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVDGYARKNCYIAAQ
....|...||. |   |    |.    .| |  .||. .  ||| |||.| || . .|||| .|.|| .|| .|. |
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkee.eyinasyvegyktknafivtq

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 849-922 6.9e-12 39.7 In-house 12-86 (287) alignment
Range on Protein: 849-922
Range on HMM: 12-86/287.0
SDQEFDNEFKSIpMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL--TTKRDSDYINACFVDGYARKNCYIAAQ
 |.|.|.  .    .| | .      |.. |||. ...|.| |||.|  ...  |||||| .| .| ... .||||
vdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaq

Y_phosphatase Protein-tyrosine phosphatase 876-922 1.2e-11 39.9 Pfam-A 1-48 (235) alignment
Range on Protein: 876-922
Range on HMM: 1-48/235.0
NIPKNRFLNIFPYDATRVVL-TTKRDSDYINACFVDGYARKNCYIAAQ
|  |||. .| ||| ||| |  .. .|||||| .|.|| .|. .||.|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQ

Y_phosphatase Protein-tyrosine phosphatase 876-922 1.2e-11 39.9 In-house 1-48 (235) alignment
Range on Protein: 876-922
Range on HMM: 1-48/235.0
NIPKNRFLNIFPYDATRVVL-TTKRDSDYINACFVDGYARKNCYIAAQ
|  |||. .| ||| ||| |  .. .|||||| .|.|| .|. .||.|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQ

subfamily_CG7180_pd Subfamily CG7180 848-921 2.2e-11 37.9 In-house 14-90 (296) alignment
Range on Protein: 848-921
Range on HMM: 14-90/296.0
NSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFVDGYARKNCYIAA
.   |.. |.| .|  .      |  . |. |||  .. ||| .||||..   . .|||||| .||.. .|. ||  
kfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivt

subfamily_PTPN6_pd Subfamily PTPN6 847-922 3.9e-11 37.5 In-house 22-104 (306) alignment
Range on Protein: 847-922
Range on HMM: 22-104/306.0
SNSDQEFDNEFKSIPM---TSGAAYTVGSSEANIPKNRFLNIFPYDATRVVL--TTKRDSDYINACFVDGYAR--KNCYIAAQ
| . . | .||...     ..    . |.   |  |||. ||.|.| |||.|      .|||||| .... ..  ...|||.|
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatq

fn3 Fibronectin type III domain 472-545 4.4e-11 36.0 Pfam-A 9-83 (85) alignment
Range on Protein: 472-545
Range on HMM: 9-83/85.0
PSISDTAVNLTWRPPLYPNGRITGYNITNDNNGRS-YWIPITSVELVYSRIVTELSIGMLYNFTIRAFNELGGGE
 ....| ..|.| ||  ..| ||||...  . | . .|  .|  .  .| ..|.|  |. |.|...| |. |.|.
sevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 837-922 7.1e-11 36.2 In-house 6-97 (439) alignment
Range on Protein: 837-922
Range on HMM: 6-97/439.0
VFHSHVLEMHSNSDQEFDNEFKSIPMTSGA---AYTVGSSEANIPKNRFLNIFPYDATRVVL---TTKRDSDYINACFVDGYARKNCYIAAQ
 |. || ... | .. |...|..|  ||       .. . | . .|||. .. ..| |||.|        | |||| ...||  .. |||.|
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatq

subfamily_PTPN23_pd Subfamily PTPN23 848-922 9.5e-11 36.0 In-house 12-89 (288) alignment
Range on Protein: 848-922
Range on HMM: 12-89/288.0
NSDQEFDNEFKSIPMTSGA---AYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVDGYA-RKNCYIAAQ
.   ..|..|| . ..  .     ..  .. .  |||. .|.||| .||.|  ..| |||||.|| . .    ..||.|
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskD.DYinAsfvkdlspgcPdfiatq

subfamily_PTPN3_pd Subfamily PTPN3 867-922 4.4e-10 33.9 In-house 32-90 (280) alignment
Range on Protein: 867-922
Range on HMM: 32-90/280.0
AYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVD----GYARKNCYIAAQ
| ..    .|..|||. .| ||||||| |.  .  ||||| .|.    . .  | |||.|
aisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatq

0037934 (Phosphotyrosine protein) phosphatases II 869-922 8.4e-10 34.1 In-house 3-50 (243) alignment
Range on Protein: 869-922
Range on HMM: 3-50/243.0
TVGSSEANIPKNRFLNIFPYDATRVVLttkRDSDYINACFVDGYarKNcYIAAQ
.......|..|||. .|.||| .||.|    .|||||| .....  .. .|| |
siallpenlsknrysdilpydhsrvkl...egsdyinanliyvt..pr.liatq

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 851-922 3.7e-09 31.1 In-house 5-79 (274) alignment
Range on Protein: 851-922
Range on HMM: 5-79/274.0
QEFDNEFKSIPMTS-GAAYTVGSSEAnipKNRFLNIFPYDATRVVLTT----KRDSDYINACFVDGYAR-KNCYIAAQ
.....|| ..|.    . ..|  |.    |||. .|.| . .||.|..    . ||.|||| .. || . ...|.|.|
kdlekeflelPlnfdqeeldvfgsqt...knryktilPnensrvllesessededssyinanyikGydeeskayvatq

subfamily_PTPN14_pd Subfamily PTPN14 842-922 5e-09 30.6 In-house 15-99 (300) alignment
Range on Protein: 842-922
Range on HMM: 15-99/300.0
VLEMHSNSDQEFdNEFKSIP-MTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRD--SDYINACFVDGY--ARKNCYIAAQ
.||.. .. . |  |.  || .   | ..... . | .|||| .. ||. .|| |.. ..  ..||||  .     ...  ||.||
ilekkleegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaq

subfamily_PTPN13_pd Subfamily PTPN13 854-918 1.3e-08 29.5 In-house 14-77 (273) alignment
Range on Protein: 854-918
Range on HMM: 14-77/273.0
DNEFKSIP-MTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDsdYINACFVDGYARKNCY
..||| .  . .    .|| ...|  |||. |..|||.||| |  .    |||| ..     |. |
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdey

fn3 Fibronectin type III domain 561-639 4.4e-08 26.3 Pfam-A 1-73 (85) alignment
Range on Protein: 561-639
Range on HMM: 1-73/85.0
SPPERVEATLShDKTTITVSWDSKTfDEVGAFFAYKVTATTTSTRKrqsgSPIEMIVPYNTTSVSFTGVNPNLMYQITA
|.||.. ..     |..|.||.  . |  | .  |.|.  .... .     . |  || .|||| .|| .|.  |... 
saPenlsvsev.tstsltlsWsppk.dgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrV

subfamily_PTPRN_pd Subfamily PTPRN 844-922 5.3e-08 26.9 In-house 22-106 (297) alignment
Range on Protein: 844-922
Range on HMM: 22-106/297.0
EMHSNSDQEFDNEFKSIPMTSG--AAYTVGSSEANIPKNRFLNIFPYDATRVVLTT---KRDSDYINACFV-DGYARKNCYIAAQ
| | .  . ...|....       .. .|...| |. |||  ...||| .|| |..   . .|||||| .. |   |. .|||.|
edhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatq

AAA_14 AAA domain 70-147 6.1e-08 19.1 Pfam-A 6-82 (128) alignment
Range on Protein: 70-147
Range on HMM: 6-82/128.0
LIYGPKGTGKTTLAARVA--VL--GHFTYIKVVTASNmIGLTDFGkieyIHQVFKDAFSSSHSLIVLDDVHRLVEYVQVGDR
.|.||...|||||. ...   |   .. ||.. ....   |.|.     ....|.. ... .....|| .... |  ..  .
vitGpRrvGKttllkqlikellkeenilyinlddeel.ekladpe....llelfleklkekkkylflDEiqkvpewedalks

fn3 Fibronectin type III domain 375-457 1.5e-07 24.6 Pfam-A 3-83 (85) alignment
Range on Protein: 375-457
Range on HMM: 3-83/85.0
PQNFI--SIpNKTFISFRWTAPEIPNGVIIIYNLTVTNLDTASttvYIINVTDSNEIIESLITGFSPYQNYTASVSASTIIGAGP
|.|.   .. . | ....|..|. ..| |  |.... . .. .   .  ..| ..   .  .||  |...|. .| | .  | ||
Penlsvsev.tstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngagegp

0049772 (Phosphotyrosine protein) phosphatases II 864-922 1.8e-07 26.7 In-house 34-90 (314) alignment
Range on Protein: 864-922
Range on HMM: 34-90/314.0
SGAAYTVGSSEANIPKNRFLNIFPYDaTRVVLtT---KRDSDYINACFVDGYarkNCYIAAQ
.   ..|.. ..|. |||.|.|.|.| .||.|      ..|||||| .|||.   . .||.|
peltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatq

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 874-922 2.7e-07 24.8 In-house 18-70 (270) alignment
Range on Protein: 874-922
Range on HMM: 18-70/270.0
EANIPKNRFLNIFPYDATRVVLTTKR---DSDYINACFVDGYARK-NCYIAAQ
  .   ||. .| |  ||||.| . .    . |||| .| |.  . . ||||.
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaam

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 872-912 3e-07 24.3 In-house 35-77 (244) alignment
Range on Protein: 872-912
Range on HMM: 35-77/244.0
SSEANIPKNRFLNIFPYDATRVVLTT--KRDSDYINACFVDGY
   ||  |||..||.|.| |||.|..  |  |||||| ...| 
vlsanatknryinilpfdetrvilssskkegsdyinanyiqgs

AAA_5 AAA domain (dynein-related subfamily) 70-139 3.3e-07 16.6 Pfam-A 3-78 (139) alignment
Range on Protein: 70-139
Range on HMM: 3-78/139.0
LIYGPKGTGKTTLAARVAVLGHFTYIKV-----VTASNMIGLTDF--GKIEYIHQVFKDAFSsSHSLIVLDDVHRLV
|. ||.||||..|| |.| .   ..  |      |.....| ...  |. ..  .....|.  . . .|||.|.|. 
lLvGppGtgKselaerlaealnreveyvqltrdtteedlkgrreiangttslvdsplvraar.egeilvlDEverae

subfamily_PTPN1_pd Subfamily PTPN1 868-922 3.5e-07 24.2 In-house 24-77 (290) alignment
Range on Protein: 868-922
Range on HMM: 24-77/290.0
YTVGSSEANIPKNRFLNIFPYDATRVVLTtKRDSDYINACFVDGYARKNCYIAAQ
 ..   ..| ..||. .. ||| .|..|  . | ||||| .|.    |  || .|
treaklpenrnlnryrdvspydhsrikle.radndyinaslveleeakrsyiltq

AAA_24 AAA domain 66-85 6.8e-07 15.4 Pfam-A 3-22 (213) alignment
Range on Protein: 66-85
Range on HMM: 3-22/213.0
MITSLIYGPKGTGKTTLAAR
 |. ||||. |.|||.||..
kikvliYGkpGiGKTslakt

subfamily_ptpA1_pd Subfamily ptpA1 846-916 1e-06 22.8 In-house 16-90 (418) alignment
Range on Protein: 846-916
Range on HMM: 16-90/418.0
HSNSDQEFDNEFKSIPMTSGAAYT-VGSSEANIPKNRFLNIFPYDATRVVLT---TKRDSDYINACFVDGYARKN
| .  ..  .||. .  . | . |  |  . |  |||. ||.| . ||| |     |  |||||| ..||   |.
hikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 848-922 1.3e-06 22.5 In-house 6-81 (283) alignment
Range on Protein: 848-922
Range on HMM: 6-81/283.0
NSDQEFDNEFKSIPMTSGAAyTVGSSEANIPKNRFLNIFPYDATRVVLTTKRDsDYINACFVD---GYARKNCYIAAQ
|. . | . .| . . .  | .. |.. | .|||. .| |.|  || | ..   |||||.|.     | ... ||.||
nnnklfrevlkrlsvpdlda.diasadenkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaq

0041856 (Phosphotyrosine protein) phosphatases II 876-922 3.2e-06 22.3 In-house 1-40 (182) alignment
Range on Protein: 876-922
Range on HMM: 1-40/182.0
NIPKNRFLNIFPYDATRvvlttkrDSDYINACFVDGYARKNCYIAAQ
|..|||. .|.||| .|       |.||||| ...|. . . .||.|
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatq

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 831-913 3.9e-06 20.5 In-house 4-87 (440) alignment
Range on Protein: 831-913
Range on HMM: 4-87/440.0
KPIHVSVFHSHVLEmhSNSDQEFDNEFKSIPMTSGAAYTVGSSEANIPKNRFLNIFPYDATRVVLTTK---RDSDYINACFVDGYA
.|| |. |  .| .  .   . |..|.  .|        . |   |  |||. ||. || .||.|       ||||||| ...|  
rpiivadfadyvqn..nrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 857-922 7e-06 19.7 In-house 17-81 (332) alignment
Range on Protein: 857-922
Range on HMM: 17-81/332.0
FKSIPMTSGAAYTvgSSEANIPKNRFLNIFPYDATRVVLTTKR-DSDYINACFVDGYARKNCYIAAQ
...  ||   .|       |.  ||   .. .| .|| |. .    |. || .||||..|..|| ||
mhtsamtypntyd..kflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaq