Gene PTPRD-38 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP093_AA protein Get Run
AqueP093_AA_723-1003 phosphatase_domain Get Run
AqueP093_AA_1083-1320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 731-1019 1.2e-166 547.6 In-house 1-283 (283) alignment 
Range on Protein: 731-1019
Range on HMM: 1-283/283.0
NNLRNNNNKLFREQFKRLGVPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRfldcqhTYVNASYIMVNKDDEQGQKYIATQGPLDRTVVDFWRM
.|||.||||||||..|||.||||..||||.||||..||||.|||.|....||....|      .|.||..|.|.|...|..|||..|.||||||||||.|
dnlrvnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkm

VWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQ
|..||..|||||||||||||||||||||.|||||||.|||||.||||||||||.||.|.|..||.||||..|||.|||||||.|..|||||||||.||.|
vfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislq

TEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQSTIS
||.||||||||||||.|||..||..|.|.|||||||..|..|||.||||||||..||||||.||||.||||||||||||||.||||||.
teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqstia
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1025-1326 2.3e-123 405.6 In-house 1-283 (283) alignment 
Range on Protein: 1025-1326
Range on HMM: 1-283/283.0
DNASVTGFEAQFNVLEQVSVPPQDAVyikkyyqvitsttciIVSSSSSSSllLLLLLLLIVADQWRVHLKSESPDYINAVFIPVliinlyviflsSQSYK
||..|........||...|||..||.               | |..            ...||||||.|||||.||||||||||           |.|||
dnlrvnnnklfrevlkrlsvpdldad...............iasadenkr..knrnqeivpadqwrvelksesrdyinavfipv...........sksyk

NDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLVRNN---KNNMLrrLAHFQVD
.||..|||||||..|..|||||.||..||.||||....|.....|.|||||.|....||||...|.|....||..|.||.|.|   |...|  |||.||.
qdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll..lahyqvi

GWsnddiTSCNEGAIINTM---NLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLA---
.|     ....|.||||..   |.|..||..|...|...|||..|||.|||.||.|.|......||||||..||.||.....|||...|||..|.|.   
dW.....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq

-------AAYVNLFSTSA
       .|.|.|.||.|
alcgdtqiaavdlqstia
subfamily_PTPRD_pd Subfamily PTPRD 720-1043 9.1e-93 306.8 In-house 4-324 (564) alignment 
Range on Protein: 720-1043
Range on HMM: 4-324/564.0
RIPLEEFGQYVNNLRNNNNKLFREQFKRLGV-PDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFldCQHTYVNASYIMVNKddeQGQKYIATQG
 || .|. ..|..|. |..  | |..|..   .  ... |. ..||. || .|||.|| . . |....     .  |.|||.|   .   . ..||||||
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyr...krkayIAtqg

PLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLhVSGSAQSTLLITHYQFIDWLEYGPQPPIN
|| .|. |||||||... . |||||||.|  . ||..|||..|.| || .||||..|.. . ..||...|    . ...  .....|..| . |     .
PlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesat

SLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQSTI
||... . ... .|...|||||||| | ||||.|| ... .. . .|  .||  .|. .|.|| .|.|| .||. .|||.||   ||.|.. . .|....
slLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhl

SSLSSSD-NASVTGFEAQFNVLEQV-S
. |.. . . ..||.|. |. |.    
qkLaeveedtemtgleleFqrLatake
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 721-1001 2.5e-80 264.4 In-house 2-282 (290) alignment 
Range on Protein: 721-1001
Range on HMM: 2-282/290.0
IPLEEFGQYVNNLRNNNNKLFREQFKRLG--VPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFLDCQHTYVNASYImvnKDDEQGQKYIATQG
||...||..| | . ..|. ||.|||.|     .  . .. . .||. || .|||.|| | | | |..   ||.. |.||.||   |. .. ..||||||
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyi...kgykekkqyiatqg

PLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYG-PQPPI
|. .|.||||...|||| ..|||||. .|. . || ||||......||.|...|..|.| |..|.|.| .. . ||...  .|.||.  | . |  . | 
pvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpq

NSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
 .|. ..... .|  . ...|||||| . ||.. |. .  .|. . ||  ||. .|.  .| |.. ..|| .|| .... ||. 
tillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 720-1033 2.3e-79 261.8 In-house 4-315 (319) alignment 
Range on Protein: 720-1033
Range on HMM: 4-315/319.0
RIPLEEFGQYVNNLRNNNNKLFREQFKRLGVPDL-PTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFLDcqHTYVNASYIMVNKddeQGQKYIATQG
 |...|. .....|... ..|....|| |  ..   .| || .|||. || |||..||   . | .|.   .   .|.|||.|   .   . .|.||||.
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgveg..sdyinasfidgyq...erekfiatqa

PLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPIN
||. |. |||||||.|..  .||||||.| |..|...|||.   |.|| ..|||..|   . .|||.|.|.   |   |  ..|.|. .| . .      
PlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat

SLVKFNKIISNQTEH-KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQST
||... | | . .|. ..|||||||| | ||||.|| ..  .     |...|.  .|  .| || .|.|. .|| ...||.|| . .|||.|   ||.  
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdr

ISSLSSSDNAS-VTGFE
. .|.. .  .  ||.|
lkqlaekvadtgetgle
0050432 (Phosphotyrosine protein) phosphatases II 715-1005 4.5e-79 261.3 In-house 20-302 (308) alignment 
Range on Protein: 715-1005
Range on HMM: 20-302/308.0
VISSVRIPLEEFGQYVNNlrNNNNKLFREQFKRL--GVPDLPTDIASSDENKPFNRNQNIVPYDVNIIELeplprflDCQHTYVNASYIMVNKdDEQGQK
. || ....... .....   ....|..|.|..|    |.|....|.  |||..||  .|.||| . . |       |  ..|.||||...     . .|
lvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgys.sklprk

YIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR---GSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQStLLITHYQFIDWL
.|||||||. || |||||||...   |||||||.|. |.|| ||||.    ||. ||.||||| .|.. .....|.|.|  .|. .| . .||.....| 
fIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWp

EYGPQPPINSLVKFNKIISNQTehKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCG
..|  | ...|..| ... ..   ..|||||||| | ||||.|| . . .    .|  .|.. .|  .||||..|.||..||.....|.|| ... 
dhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0051299 (Phosphotyrosine protein) phosphatases II 719-1001 6.1e-79 260.8 In-house 3-285 (288) alignment 
Range on Protein: 719-1001
Range on HMM: 3-285/288.0
VRIPLEEFGQYVNNLRNNNNKLFREQFKRLGV--PDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYImvnKDDEQGQKYIAT
 .|..||. ..|..|. |......|.|..|    |||.. .|.  ||.. ||...|.||| . . | .|.   .  ..|.|||||   .  ....|.|||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyi...dgynlkrkfIat

QGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSG---SAQSTLLITHYQFIDWLEYGP
||||. || |||||||...   |||||||.|. |.|| ||||..||. ||..|||| .|.. .....|.|..   .     . .. .||.....| ..| 
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

QPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
 . ...|..| ... .. ....||.||||| | ||||.|| . . .   ..|  .|.. .|  .||||..|.||..||..|.||.|| 
pdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 721-1036 7e-78 256.9 In-house 2-315 (318) alignment 
Range on Protein: 721-1036
Range on HMM: 2-315/318.0
IPLEEFGQYVNNLRNNNNKLFREQFKRL-GVPDLPTDIASSD-ENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMVNKDDeqgQKYIATQG
|..|.. . |..||.. . |. |...||  ... .| . | .  ||  || .||..||   ..|..|    . .  |.||.||  .. .   ..|||.|.
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmleg..eegsDyinanyidGyrrk...kayiaaqa

PLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTlLITHYQFIDWLEYGPQPPIN
|| .|. |||||||. ... |||||...|  ..|. .||||.||. ||  .|.|..|........||.... ... .|   .  |.. .| . |      
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesr.qvrqyhytsWpdegvpesga

SLVKFNKIIS-NQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQST
||... . .|  |.....||||||||.| |||| || ..  .. .  |...|.  .|. .|||| .|.|| ||| ......||   .|||.. | ||.| 
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsr

ISSLSSSDNA-SVTGFEAQF
|  |  .|.    | ..|.|
irelreqdpesgttemdaef
0040438 (Phosphotyrosine protein) phosphatases II 731-1018 3.8e-76 251.7 In-house 10-292 (317) alignment 
Range on Protein: 731-1018
Range on HMM: 10-292/317.0
NNLRNNNNKLFREQFKR-LGVPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFLDcqHTYVNASYImvnKDDEQGQKYIATQGPLDRTVVDFWR
. | ........|.|.. | ..  ....|.  |||..||. .|.||| . . | ||.  ||  ..|.||||.   .  ....|.|||||||. || ||||
ldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdld..sdYInAsyv...dgpnlkrkfIatqgPlpntvedFwr

MVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSgSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISN
|||... . |||||.| |. |.|| ||||....  ||.|||||..|.. .....|.|..  .   . .. .||.....| ..|. | ...|..| ... .
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavre

QTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQSTI
. |...||..|||| | ||||.||.. . .    .|  .|.. .|  .||||....||..||. ...|.||  ....| . |..| . .
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 721-1020 5.4e-76 250.7 In-house 4-301 (305) alignment 
Range on Protein: 721-1020
Range on HMM: 4-301/305.0
IPLEEFGQYVNNLRNNNNKLFREQFKRLGVPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFLdcQHTYVNASYIMVNKddeQGQKYIATQGPL
| |... .|... | ...| . .|.| |   . ..|. ....||  ||...|...| . | | . .     .. |.||||.   |   . .|||..||||
ialddlaayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgyk...rkkkyivaqgPl

DRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE--DYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPIN
. ||.||||....||   |||||||.|. . || |||| . .|  ..|.|.|.|. |.| . .|.|.|.. .  . . .  ...||. || . |      
kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

SLVKFNKIISNQTEHKKG-PIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQST
||... | . .. .. || |..|||| | ||||.|| ..  .  . .| ..|.  |.  .|..|| |.||||||. .|.|. |   ||||.|   .|.  
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar

ISS
.  
vnk
0046845 (Phosphotyrosine protein) phosphatases II 750-1006 3.8e-74 244.9 In-house 11-278 (284) alignment 
Range on Protein: 750-1006
Range on HMM: 11-278/284.0
VPD----LPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFlDCQHTYVNASYIMVNKDD--EQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLT
       |....|   ||.  || ..|.||| . . | .|.   .  ..|.||||. .   |   . .|.|||||||. || |||||||....  |||||
sltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmlt

KLQEDLRIKCSQYWPSRG-SEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTE--HKKGPIVV
.| |. |.||.||||. | .  ||.||||| .|.. .....|.|.|   |  . .. .||.....| ..|  | ...|..| ... .. |  ...|||||
elvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivV

HCSTGGGRTGAFIGMSCSIKDALTES---IIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGD
||| | ||||.|| . . ..   .|.    .|.. .|  .||||..|.|||.||..|.||.|| .... 
HCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_PTPRB_pd Subfamily PTPRB 719-1000 4.7e-74 244.1 In-house 5-283 (293) alignment 
Range on Protein: 719-1000
Range on HMM: 5-283/293.0
VRIPLEEFGQYVNNLRNNNNKLFREQFKRLGV--PDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYImvnKDDEQGQKYIAT
  | ||.| ..|........  | |....|     |  ...|.. .|.  || .||.||| . ..|..|    . .  |.||.||   .. .. ...|||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkd..esgsDYinanyi...pgynsprefiat

QGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR-GSEDYGPFTVTLQKETTSNSFIIRELTLHVsgsAQSTLLITHYQFIDWLEYGPQP
||||  || |||||||..|. .|||||.| |  ..|| .|||.   .  ||  .|||..|.. . ..||||...    ....  ...|.|. | ..|   
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPe

PINSLVKFNKIISNQT--EHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
  ..|..| . . ...  ...|.||||||| | ||||.|| .   ...  .| ..|| ..|. .||.|....|| .||. .|..||.
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
0036941 (Phosphotyrosine protein) phosphatases II 750-1013 5e-73 241.3 In-house 26-288 (297) alignment 
Range on Protein: 750-1013
Range on HMM: 26-288/297.0
VPDLPTDIASSDENKPFNRNQNIVPYDVNIIELeplprfLDCQHTYVNASYImvnKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDL
 .. ....|.. ||.. ||  .|.||| . . |       |  . |.||||.   .  ....|.|||||||. || |||||||...   |||||.| |. 
lllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyv...dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelg

RIKCSQYWPSR--GSEDYGPFTVTLQKETT--SNSFIIRELTLHVSGSAqSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH--KKGPIVVHCS
|.|| ||||.   .|  ||.|||||.....  ......|.|..   |.   .. .||.....| ..|. . ..||..| . . .. ..  ..||..||||
rekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCs

TGGGRTGAFIGMSCSIKDAL---TESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACD
 | ||.|.||.. . .       .|  .||. .|  .||||....|||.||. ..||.||  ....| . ...
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0039614 (Phosphotyrosine protein) phosphatases II 712-1005 1e-72 240.5 In-house 5-292 (297) alignment 
Range on Protein: 712-1005
Range on HMM: 5-292/297.0
KEGVISSVRIPLEEFGQYVNNLRNNNNKLFREQFKRLGVPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFlDCQHTYVNASYImvNKDDEQGQ
 . . .|. |||. . ...  .. |.. |....|..|     .. || . |||..|| ..|.||| . . | |.. . |  ..|.||||.  .  |  ..
rdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyv..dgydlltr

KYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRiKCSQYWPSRGSeDYGPFTVTLQKETTSNSFIIRELTLHVsgsAQSTLLITHYQFIDWLEY
|.|||||||. || |||||||...  .||||||| |. | || ||||..|.  ||.||||| |... . ...|.|..      . .. .||.|...| ..
kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdh

GPQPPINSLVKFNKIISNQTEH--KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCG
|. | ...| .| ... .. ..  |.||..|||| | ||||.||..   .    .|  .|.. .|  .||||....||..||. ...|.||  ...
gvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPRK_pd Subfamily PTPRK 724-1025 1.4e-72 239.2 In-house 7-300 (314) alignment 
Range on Protein: 724-1025
Range on HMM: 7-300/314.0
EEFGQYVNNLRNNNNKLFREQFKRLGVPdlpTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYImvnKDDEQGQKYIATQGPLDRT
..  | .. |. ...  |.|... |       | |  |||.  || ..|..||   . | ..    | .  |.||..|      .. ...|.|||||. |
adllqsiallkraegygfkeeyeslfeg...wdaakkdenreknrsgdilaydrsrvflitidg..dpssdyinaali...dsykrpaafivtqgPlqet

VVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEdYGPFTVTLQKETTSNSFIIRELTLHV-SGSAQSTLLITHYQFIDWLEYGPQPPINSLVK
| ||||.|..|....|||||.|.|  |.||..|||  ..  ||.. |.| . .. . ...| ....  . . . . .. ..||. | ...     ..|.|
vkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk

FNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQSTISSLS
. . . ...|...|.||||||.|.||||.|| ..  .  . .|...|.  .|  .|.... |..| .||.......|| .|||.| | .......  . .
lvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesi

SSD
  |
rld
0043336 (Phosphotyrosine protein) phosphatases II 730-1000 2e-72 239.3 In-house 12-275 (278) alignment 
Range on Protein: 730-1000
Range on HMM: 12-275/278.0
VNNLRNNNNKLFREQFKRLGVPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFLDcqHTYVNASYImvnKDDEQGQKYIATQGPLDRTVVDFWR
.. |.|.. .| .| .. | ..  ...|| . |||..||  .|.||| . . |..|.  ||  ..|.||||.   .  ....|.|||||||. || ||||
lelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyv...dgynvprkfiatqgPlpetvedFwr

MVWQEKACAIVMLTKLQEDLRIKCSQYWPsRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQStLLITHYQFIDWLEYGPQPPINSLVKFNKIISN
|||...   |||||.| |. |.|| |||| .||. ||.|||||.||.. . ...| |...  |. .| . .|||....| ..|  .....|..| |.. .
mvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavre

QTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
. |...||..|||| | ||||.||..   .  . .|  .|.. .|  .||||....||..||. ..||.||
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 721-1009 2.2e-72 238.5 In-house 2-285 (287) alignment 
Range on Protein: 721-1009
Range on HMM: 2-285/287.0
IPLEEFGQYVNNLRNNNNKLFREQFKRLGV-PDLPTD--IASSDENKPFNRNQNIVPYDVNIIELEplprflDCQHTYVNASYIMVNKDDeqgQKYIATQ
||.|.||..|.. ....|. |..||. |    . . .  .. . .||. || ..|...| . . |.      .... |.||..|   |..   ...|...
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykek...kafiiae

GPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYG-PQPP
.|. .|...||.......  |||||....|. . .| ||||.  |  .|.....| .|......|.|.| .. ...|.... .. ||. .| . |  . |
sPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtep

INSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQI
  .|. ... . .|  . ...|||||| . ||.. |. .  .|. . || .||.  |.  .| |.. ..|| .||. . ..|||.  ...|. 
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
0047943 (Phosphotyrosine protein) phosphatases II 751-1000 3.9e-72 238.3 In-house 26-270 (273) alignment 
Range on Protein: 751-1000
Range on HMM: 26-270/273.0
PDLPTDIASSDENKPFNRNQNIVPYDVNIIELeplprfLDCQHTYVNASYImvnKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLR
|.|.. .|.  ||| .||...|.||| . . |       |  . |.||||.   .  ....|.|||||||. || |||||||....  |||||.|.|. |
plltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyv...dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgr

IKCSQYWPSRG---SEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQsTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH--KKGPIVVHCSTG
.|| ||||. |   |. ||.||||| .|.| .....|.|.|  .|. . .. .||... .| ..|  | ..||..| ... .. |.  ..||.||||| |
ekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaG

GGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
 ||||.|| . . .    .|  .|.. .|  .|.||..|.||..||....||.||
vgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_PTPRA_pd Subfamily PTPRA 720-1023 4.1e-72 237.8 In-house 13-316 (330) alignment 
Range on Protein: 720-1023
Range on HMM: 13-316/330.0
RIPLEEFGQYVNNLRNNNNKLFREQFKRLGVPD--LPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFlDcQHTYVNASYIMVNKddeQGQKYIATQ
 .|.|.. . ..    ..||||||.|. |   .     ..|| .|||  ||  ||.||| . . | ..    . .  |.|||.|   |   . .|.||.|
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGv.e.esdyinasfidGyk...ekdkfiaaq

GPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSA---QSTLLITHYQFIDWLEYG-P
||...|| |||||.|. |...|||||.|.|  . || ||||. |.  ||  .|....|| .... .|.. ..  . |   ... |.. . |  | . | |
GPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvP

QPPInSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACD
  ||  ..|. | . .. . . ||||||||.| ||||.|| ..  ..   .| ..|.  .|  .| ||  |.||. || ......||  | |||.. .  
fepi.GmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvss

LQSTISSLSS
|.. . .| .
lekhlqklyn
DSPc_SM00195 754-1000 3.3e-70 231.8 In-house 17-260 (263) alignment 
Range on Protein: 754-1000
Range on HMM: 17-260/263.0
PTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFldCQHTYVNASYIMVNkddEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKC
.|. |  ..||  || .||.||| . ..|.. .     ...|.||.|| ..   .. .|||||||||. || |||||||.||   |||||. .|. ..||
etteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

SQYWPSR--GSEDYGPFTVTLQKETTSN-SFIIRELTLHVSGSaQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTG
..|||.   |.|..| ..|.|..... . ..|.|.|.|   |  . |  .|.||. .| . | .   .|.... . . .......||||||||.| ||||
drywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtg

AFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
.|. ... ..   .|. .|| ..|. .|.||..|.|||.||. ..||.||
tfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 754-1000 3.3e-70 231.8 In-house 17-260 (263) alignment 
Range on Protein: 754-1000
Range on HMM: 17-260/263.0
PTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFldCQHTYVNASYIMVNkddEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKC
.|. |  ..||  || .||.||| . ..|.. .     ...|.||.|| ..   .. .|||||||||. || |||||||.||   |||||. .|. ..||
etteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikga...nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

SQYWPSR--GSEDYGPFTVTLQKETTSN-SFIIRELTLHVSGSaQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTG
..|||.   |.|..| ..|.|..... . ..|.|.|.|   |  . |  .|.||. .| . | .   .|.... . . .......||||||||.| ||||
drywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtg

AFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
.|. ... ..   .|. .|| ..|. .|.||..|.|||.||. ..||.||
tfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0045450 (Phosphotyrosine protein) phosphatases II 726-1000 7.2e-70 231.5 In-house 14-302 (307) alignment 
Range on Protein: 726-1000
Range on HMM: 14-302/307.0
FGQYVNNLRNNNNKLFREQFKrlGVPDL------PTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFlDCQHTYVNASYIMVN-----KDDEQGQKYI
. ..|. |  ... .....|.   ....      ...||.. |||..|| ..|.||| . . | .|.   .  . |.||||..|.     .   ...|.|
llllvllllldfltgllkefe..kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfI

ATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE-DYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGP
||||||. || |||||.|...  .|||||.| |. |.|| ||||. |.|  ||.||||| .|.. .....| |... ..  . .. .||.....| ..| 
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgv

QPPINSLVKFNKIISNQTEH--KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESI---IDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
 | ...|..| ... .  |.  |.||..|||| | ||||.||..   ..   .| .   .|.. .|  .||||. ..|...||. ..||.||
ppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 728-1000 2.5e-68 225.3 In-house 10-277 (288) alignment 
Range on Protein: 728-1000
Range on HMM: 10-277/288.0
QYVNNLRNNNNKLFREQFKRL-GV-PDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFLDcqHTYVNASYImvnKDDEQGQKYIATQGPLDRTVV
..|..   .|.. | |... |  .  .  .....  .|.. || .||.||| . ..|. |.   .    |.|||||   ..... .|||||||||  || 
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeag..aDYinasyi...dgekkkkkyiatqgPladtvn

DFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGS-EDYGPFTVTLQKETTSNSFIIRELTLHvsgSAQSTLLITHYQFIDWLEYGPQPPINSLVKFN
|||..|...|.  |||||.| |. . || .|||. .  . || .||||... . ..|. |.| |.     .. | ||.||.  | . |     . |... 
dfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllell

KIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
... .. . . |||.|||| | |||| || . . |.   .|  ||. ..|. .|.||....||| ||. ..|..|.
rqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPRG_pd Subfamily PTPRG 721-1016 4.1e-68 225.0 In-house 1-301 (563) alignment 
Range on Protein: 721-1016
Range on HMM: 1-301/563.0
IPLEEFGQYVNNLRNNNNKLFREQFK----RLGVPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFlDCQHTYVNASYIMVNKddeQGQKYIAT
.|..|| ..| .|  .... | |.|.    .    ||... ..  |||  ||. |||.||   ..|.|||   . .. |.||.||.  .   .....|||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgk.kkklDYinAnyidGyq...kskafiat

QGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKET-----TSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEY
||||  |. |||||.|....  |||.|.|.|. | || .|||. .||.|| ..|||..|      |.....|..| |.   .... .|...|.. .| . 
qgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdh

GpqPPINSLVKFNKIISNQT--EHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQI
|   |  || . . .. ...  ... ||||||||.|.|||| .| ..  .|.  .|.....  ..  .| || ...|| .||. .|.|.||  . ..|..
g..vPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketel

AACDLQS
 | ....
laeqvee
Y_phosphatase Protein-tyrosine phosphatase 763-1000 2.2e-67 222.3 Pfam-A 1-235 (235) alignment 
Range on Protein: 763-1000
Range on HMM: 1-235/235.0
NKPFNRNQNIVPYDVNIIELeplprF-----LDcqhtYVNASYIMVNKDdeqGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYW
||  ||...|.||| . ..|            |    |.||.|..  |.    .|.|||||||. |. ||||||||||  .|||||.|.|  | ||.|||
nkkknRykdilpydktrvkl.....kgsegpsd....YInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYw

P--SRGSEDYGPFTVTLQ-KET-TSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFI
|  ...|. || ..|.|. ||.  ......|.|.|. ... . .  ...... .| ..| .   .||... . . ...|.|.||.|||||.| |||| |.
peeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfv

GMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
 ... .. . .|. .|.  .|  .|.||..|.|.|.||. ...|.||
aldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 763-1000 2.2e-67 222.3 In-house 1-235 (235) alignment 
Range on Protein: 763-1000
Range on HMM: 1-235/235.0
NKPFNRNQNIVPYDVNIIELeplprF-----LDcqhtYVNASYIMVNKDdeqGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYW
||  ||...|.||| . ..|            |    |.||.|..  |.    .|.|||||||. |. ||||||||||  .|||||.|.|  | ||.|||
nkkknRykdilpydktrvkl.....kgsegpsd....YInAnyvkgyke...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYw

P--SRGSEDYGPFTVTLQ-KET-TSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFI
|  ...|. || ..|.|. ||.  ......|.|.|. ... . .  ...... .| ..| .   .||... . . ...|.|.||.|||||.| |||| |.
peeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfv

GMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
 ... .. . .|. .|.  .|  .|.||..|.|.|.||. ...|.||
aldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 728-1009 3.4e-67 221.8 In-house 16-297 (298) alignment 
Range on Protein: 728-1009
Range on HMM: 16-297/298.0
QYVNNLRNNNNKLFREQFKRLG-----VPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPrfLDCQHTYVNASYIMVNKDDEqgqKYIATQGPLDR
....  ....   . ..|.||      ...  ...|...|||  || ..|...|   . ||      | . .|.|||..   |. .    .||||.|| .
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrn...afiatqaPlte

TVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAqSTLLITHYQFIDWLEYGPQPPINSLVK
||.||||||..|.. .|||||.|.|  ..|...|||..|.| || .||.|... .   .|.|.|... . .. ..  . . .|. | . |     .|...
tvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvld

FNKIIS-NQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQI
. . .  .|.. .. |..|.|| | ||.|.|| ..  .  . .|. .|.  || ..|..|. ..|| .||. ..|||||   .....|
llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0045098 (Phosphotyrosine protein) phosphatases II 745-1005 1.3e-66 220.1 In-house 15-275 (278) alignment 
Range on Protein: 745-1005
Range on HMM: 15-275/278.0
FKRLGVPDLPTDIASSDENKPFNRNQNIVPYDVNIIEleplprfldcqhTYVNASYIMVNkddeqGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTK
|..|  .      |   .|...||  .|.||| . .              |.|||||..      ..|.|||||||. || |||||.|...  .|||||.
fllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy.....pkkfIatqgPlpstvadfwrmlwelgitvivmlte

LQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVS---GSAQSTLLITHYQFIDWLEYGPQPPI--NSLVKFNKIISNQTEH------
|.|. |.|| ||||..||. ||.|||||..|.. . ...| |...      .   .. .||.... | ..|. .    .|. .. . | .  ..      
lvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------KKGPIVVHCSTGGGRTGAFIGMSCSIKDAltESIIDIPAVVTIMREQRMM-MIQTLDQYMLVHEAVLEQALCG
       ..||..|||| | ||||..... . ..    |. .|.. .|. .|.||.. ..|.|.||. ..|..||  |.|
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0040439 (Phosphotyrosine protein) phosphatases II 755-1000 1.4e-64 213.4 In-house 3-244 (249) alignment 
Range on Protein: 755-1000
Range on HMM: 3-244/249.0
TDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYImvnKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCS
...|.  |||. ||...|.||| . . |..||      . |.|||||   .   .....|||||||. || |||||.|...  .|||||.|.|  |.|| 
ysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyi...dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekca

QYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSgSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH--KKGPIVVHCSTGGGRTGAF
||||..||  || ||||| ..........|.|.|. .   .... ..|.|..|| ..|  | ...|..| ... .  |.  |.||..|||| | ||||.|
qywplggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

IGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
|..   .    .|  .|.. .|  .|.||....|...||. ..||.||
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 721-1040 3.3e-64 211.8 In-house 2-315 (515) alignment 
Range on Protein: 721-1040
Range on HMM: 2-315/515.0
IPLEEFGQYVNnlRNNNNKLFREQFKRLGVPDL-PTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMVNKDDeqgQKYIATQGP
.|| .|  .||  .|..  || |.|. |  |.. |  .|  . | . || .||.||| . . || .    . .. |.|||||   . |   . |||.|||
lplaqfPafvn..knrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevind..nPhsdyfnasyipsfdnd...kayiasqgP

LDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPS--RGSEDYGPFTVTLQKETTSNSFIIRELTLhVSGSAQSTllITHYQFIDWLEYGPQPPI
.. .| ||||.|.||.  .|.|.|||.|. .|||..|||     |  .| . | |    .    |.|.||. . |.   |  .| ..| .| . | ..  
nkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv.lkgddsrt..vtqfhfteWPdkGvpkht

NSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQST
.||.|. | .  .... . |...|||.| |||| .| .   . .| |  ..|.  .||..|..|. ..|| .|| ....||||. |  .| |    .   
ssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdh

ISSLSSSD-NASVTGFEAQFNVLE
.  | ||      . .  .|. |.
lqdlhssgdgrgrskmtkefqtlk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 721-1026 3.6e-64 211.6 In-house 3-301 (315) alignment 
Range on Protein: 721-1026
Range on HMM: 3-301/315.0
IPLEEFGQYVNNlrNNNNKLFREQFKRLGVPDL-PTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMVNKDDeqgQKYIATQGP
||. .|  .||.  | .  || |.|. |  ||  .. .|  ..| . || .||.|.| . . || .    . .. |.|||||   .||   . |||.|||
ipvaqfpafvnk..nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevidd..sPdsdyinasyiksvddd...kayiasqgP

LDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPS--RGSEDYGPFTVTLQKETTSNSFIIRELTLHVSgsaQSTLLITHYQFIDWLEYGPQPPI
|. .| ||||||.|||. .|||.||.||. .||| ||||     | ..| . |.| .  .    ..|.|..  |   ...  .| .|| .| . | .   
lkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrks...eesrtvtqfqftewPdkGvdkqt

NSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQST
 ||.|. | .  . ..|. ...||||.| |||| .| .   ....  .. .|.  .|...|..|. ..|| ..| ....||||. |  .| |    .   
ssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdh

ISSLSSSDN
.  | .| .
lqdlhtsvd
subfamily_Ptp69D_pd Subfamily Ptp69D 720-1021 3.8e-64 211.7 In-house 3-305 (307) alignment 
Range on Protein: 720-1021
Range on HMM: 3-305/307.0
RIPLEEFGQYVNNLRNNNNKLFREQFKRLG--VPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMVNKDDeqgQKYIATQ
.|....  . ... ... . .. . ...|     |. | ..  .||.  || ..|...| . . |....   . . .|.|||.|   |.    .|.|| |
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkking..kedsdYinasfikgykek...kkfiaaq

GPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSG----SAQSTLLITHYQFIDWLEYGP
.|.. |. |||||... .   ||||..|.|  | ||..|||      ||   |.| .| . . .||||| .   .      . .  .. |..  | ..  
dPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskv

QPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACD
    ..|.|. . . .  .....|||||||.| ||.| |. ..  ..   .|  .|| ..|  .|.|| ...| |.||. .. |.|.    |||...  |
PevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvdd

LQSTISSL
|...| .|
ledaierl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 735-1000 1.1e-63 209.7 In-house 12-291 (301) alignment 
Range on Protein: 735-1000
Range on HMM: 12-291/301.0
NNNNKlFREQFKRLG-VPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFLDCQHTYVNASYIMVNKddeQGQKYIATQGPLDRTVVDFWRMVWQ
...|| | ||.|.|  . | ....  |.|||..||..||..|| | | |.| |..  ||..|.|||||   .   . .|.||.|||...|.|||||..||
khsnk.feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys...ekkkfiaaqgpmkktlvdfWrliwq

EKACAIVMLTKLQEDLRIKCSQYWPS--RGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQ--------------STLLITHYQFIDWLEYGP-QPP
||  .|||.|.|.|. . || ||||.    ||..|||||||..|..  .|.||.|....  ...              |.  .. .| .|| . |  . |
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

INSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
   |   ...|  |    .||.||||| . .|.| .. .| ..  .  | ..|.  |.  .| ... ...||.||. ..... .
rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
0042113 (Phosphotyrosine protein) phosphatases II 757-1000 6.5e-63 207.7 In-house 3-241 (245) alignment 
Range on Protein: 757-1000
Range on HMM: 3-241/245.0
IASSDENKPFNRNQNIVPYDVNIIELEPLPRFLDcqHTYVNASYImvnKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQY
.|.  |||..||. .|.||| . . | | .  ||  ..|.||||.   . ... .|.|||||||. || |||||.|...  .|||||.. |. |.|| ||
vallpenkdknrysdilpydhtrvklspdggdld..sdyinasyv...dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqy

WPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSgSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTE-HKKGPIVVHCSTGGGRTGAFIGM
||...|  || ||||| .|.. .....|.|...       .. ..||....| ..|. . ...|..| ... .. . ...||..|||| | ||||.||..
wplgesltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

SCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
   .  . .|  .... .|  .|.||....||..||. ..||.||
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 743-1024 8.9e-62 204.2 In-house 38-313 (319) alignment 
Range on Protein: 743-1024
Range on HMM: 38-313/319.0
EQFK---RLGVPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMVNKddeQGQKYIATQGPLDRTVVDFWRMVWQEKACAI
 .|.   .|||.    . |  |.||  ||  ||...| |.. ||.|         |.|||..   .   . .||||.||||| |. |||||.|. ....|
vefrracklgvnladqtfanldqnkdknriinilafdknvvklerliG..eefsdyinasfvtGyq...rkdkyiaaqGPldntladfWrmiweyncsti

VMLTklqedlRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYG-PQPPINSLVKFNKI-ISNQTEHKKGP
|.||      . ||||||| .. . .. | | ..  . .. ...|.. |   |  .    || . |  | ..| |. |.. .   .|.   .. |... .
vllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhran

IVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQSTISSLSSS
||||||.| ||||..| . . ..    |. .|.  .|  .|.||  ..| | ||.... |.||. | | ...|  |. . .  ||. 
ivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnk
subfamily_PTPN3_pd Subfamily PTPN3 750-1000 1.5e-61 202.8 In-house 28-273 (280) alignment 
Range on Protein: 750-1000
Range on HMM: 28-273/280.0
VPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEplprflDCQHTYVNASYIMVNKDD-EQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQED
 |.| ...|   || . || ..|.|||   ..|.      . .  |.||.|. .. .  .. ..||||||||..|. |||.|||..|.  ||||| | |.
kpglaisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlver

LRIKCSQYWPSRG-SEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQsTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGG
 |.|| ||||. . . .|| |.|...|| ...|...|||.|. . . .    |.. |...| . |     .....| . . .. . |. |.|||||.| |
GrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketke.erkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGig

RTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
||| .| .  ..    ..  . ....|  ||.||.|..|| .|| .| ||.|.
rtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1071-1324 1.9e-61 202.5 In-house 43-288 (290) alignment 
Range on Protein: 1071-1324
Range on HMM: 43-288/290.0
SSSSLLLLLLLLLIVADQWRVHLK--SESPD----YINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEG
.||. ||     ..| |. |. |.  |. .|    ||||..|              . ||..| .|..|.|. .| .||||.| ....| ||||  |.| 
tssnkllnRfanivvyddnritLrpisghkDCtneyinAcyi..............kgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniiee

EEEACAQYWPKEGTIEFGEFTISVREEWGHQSF-SRKLLLVRNNKNNMLRRLAHFQVDGWSNDDiTSCNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMI
... | ||||...| ..|||.| . .|  ....  ||| .  .|...  . . ..|.  | ...    |. .|. ... .   |||. ||....|||. .
gkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstg.kvtnpqtillvieemyktqrkrgntsivvHCSdtv

GRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFST
|||||||||. |....|.  |.|||| .|..|.  || || . ||..|...   |.. |.|
grsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1028-1328 2e-61 202.5 In-house 18-287 (287) alignment 
Range on Protein: 1028-1328
Range on HMM: 18-287/287.0
SVTGFEAQFNVLEQVSVPPQDaVyikkyyqvitstTCIIvsssSSSSLLLLLLLLLIVADQWRVHLKSESPDYINAVFIpvliinlyviflssQSYKNDK
. .||. || |||||.  ... |            |  |    .|.   .  |  ..| |. || || | |||||||||              ..||..|
gnegfknqftvleqvtqrede.v............thni....asqnkdknRltqilvpdnyrvllkgehpdyinavfi..............dgykekk

GFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREE-WGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSND
 ||||.||. .| |.|||.| ||..|.||||.  .| .||.| ||||.| .. .||..|.. .|   ..   ||| . ..||..  ...  .|.  | . 
afiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdst

DITSCNEgAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTSA
   .. . .|.  ..     |||. ||....|||. .||||.||||  |... |   |.|||| .|..|.  ||.||   |||.|  .  .|.. |.| .
gkvtepq.tillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

NF
.|
df
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 728-1000 4.4e-61 201.5 In-house 4-274 (281) alignment 
Range on Protein: 728-1000
Range on HMM: 4-274/281.0
QYVNNLRNNNNKLFREQFKRLGV--PDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMVNKDDeqgQKYIATQGPLDRTVV
. ...|..|.|. | |... |     | ..  . .|||.  || .||| ||   ....|  .  . .  |.||...   |..   ..|||||||.  ..|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpnee..nkntDYinanfvpgykge...keyiatqgPvPaslv

DFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG-SEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAqsTLLITHYQFIDWLEYGPQPPINSLVKFN
.||.|||..|..||||.|.  |  ..|| .|||    .  || .||. ..|......| |...|. ...   |  ... ... | . |     . |..| 
afWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresge..treveqlaytaWPdhGvPattkellefr

KIIS-NQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTE-SIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
| .   .....| |.|.|||.| ||||..|..   .| . .| . .|. |||. .|..|..|.||. ||  |. |||.
kevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 747-1024 5.4e-61 201.6 In-house 9-277 (284) alignment 
Range on Protein: 747-1024
Range on HMM: 9-277/284.0
RLGVPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMVNKddeQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTklq
.|||.      |  |.||  ||  .|...| |.. ||.|         |.|||.|   .   . .|||||||||| |. |||||.|. ....||.||   
klgvngtdqtfanldqnkdknrighilafdknvvklerliG..eefsdyinasfitGyq...rkdkyiatqGPldntladfWrmiweyncstivllt...

edlRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYG-PQPPINSLVKFNKI-ISNQTEHKKGPIVVHCST
   . ||||||| .. . .. | | ..  . |. ...|.. |   |  .    |. . |  | ..| |. |.. .   .|.   .. |... .||||||.
...kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

GGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQSTISSLSSS
| ||||..| . . ..    |. .|.  .|  .|.||  ..| | ||.... |.||. | | ...|  |. . .  ||. 
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk
0037934 (Phosphotyrosine protein) phosphatases II 756-1000 2.3e-60 199.5 In-house 3-240 (243) alignment 
Range on Protein: 756-1000
Range on HMM: 3-240/243.0
DIASSDENKPFNRNQNIVPYDVNIIELeplprflDCqHTYVNASYIMVNKddeqgqKYIATQGPLDRTVVD----FWRMVWQEKACAIVMLTKLQEDLRI
 ||.. ||.. || ..|.||| . . |       .  . |.||..|.| .      ..|||||||. || |    ||||.|...  .|||||.|.|  |.
siallpenlsknrysdilpydhsrvkl.......eg.sdyinanliyvtp......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgre

KCSQYWPsrGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQ--------TEHKKGPIVVHCS
|| ||||  |.. ||.||||| .|.. .....|.|.|   .  . |.|..||... | ..|. . ...|..| ... .         .....||..||||
kcaqywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

TGGGRTGAFIGMSCSIKDAlteSiIDIPAVVTIMREQRMM-MIQTLDQYMLVHEAVLE
 | ||||..| .   ..     . .|.  .|  .||||.. ..||..||. ..||.||
aGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 720-1012 1.3e-59 196.7 In-house 9-294 (297) alignment 
Range on Protein: 720-1012
Range on HMM: 9-294/297.0
RIPLEEFGQYVNnlRNNNNKLFREQFKRLGVPDLPTDIASSDE-NKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMVNKDdeqgqKYIATQG
 ||| .|  .|.  .| . ..|.|.|. |    . ..  . .  | . .| .||.|||.. ..|. .    | .  |||||.. .||      ..|.|| 
piplsdfatlvq..knrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnd..dpdsDyvnasfvkgnkh.....rlittqm

PLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRiKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHvSGSAQSTLLITHYQFIDWLEYGPQP--P
| . || |||.||..|.. .||||....|  . || .||. .|.  .|  .|.|.  .  . || |||..   |.|... ..  |||..| .   .    
PmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevt.kgkakarrvvkqyqfveWPdkaverkds

INSLVKFNKIISNQTEHKK-GPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAAC
..||.|. . . .. .... ||..|||..| |||| .. .   . .|  |  .||  .|. .|..|. ..|| .|| .|..||||  |. ||.| | 
assllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 757-1004 1.9e-59 195.9 In-house 3-244 (250) alignment 
Range on Protein: 757-1004
Range on HMM: 3-244/250.0
IASSDENKPFNRNQNIVPYDVNIIELEPLPrfLDCQHTYVNASYIMVNKDDeqgQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIkCSQY
.|   .||  ||  .|...|   . ||.     | .  |.|||.. . ..    . .||||||| .|..||||||..||. .|||||.|.|  .  ..||
vakkpqnkeknryadiialdssrvvLekek..gdkesdyinasflhgyder...kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqy

WPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSgSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNK-IISNQTEHKKGPIVVHCSTGGGRTGAFIGM
||  ..| ||  ||.| .. .   ...|.| |    . ..  .. ...|. | . |     .. ... | . ..| . ...|..|.||.| ||.|||| .
wPvekaekyGdvtvsllskeefadytkrklklska.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiai

SCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALC
.. .. . .| ..|.  |. ..|..|. ....|.||. |.|..|.   .
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN6_pd Subfamily PTPN6 741-999 3.4e-59 195.3 In-house 28-294 (306) alignment 
Range on Protein: 741-999
Range on HMM: 28-294/306.0
FREQFKRLGVP----DLPTDIASSDENKPFNRNQNIVPYDVNIIELEplpRFLDCQHTYVNASYIMVNKDDEQgQKYIATQGPLDRTVVDFWRMVWQEKA
| |.|..|        |  . ..  |||  || .||.|.| . . |.   .    ...|.||.||. .  ... ..|||||| |. || |||||||||..
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsd.ksyiatqgclettvsdFWrmvwqens

CAIVMLTKLQEDLRIKCSQYWPSRGS-EDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHK-
  |||.||  |  . ||..|||.  . |.||  .||  .|.. ...|.|||...   .....  . .|.| .| . | .   . ...| . .....|.  
rvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

---KGPIVVHCSTGGGRTGAFIGMSCS---IKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVL
   .|||||||| | ||||.|| . .    |.   ..  |||  .| ..||||  ..|| .|| .|..|. 
eaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1084-1326 3.2e-58 192.3 In-house 66-297 (298) alignment 
Range on Protein: 1084-1326
Range on HMM: 66-297/298.0
IVADQWRVHLKS----ESPDYINAVFIPvliinlyviflssqSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTI
|  |. || |..    |  |||||.|.               .||. . ||..| || ||  |||.|. ...|.||||| .. | ..  . .|||.||. 
ialdssRvvLekedadeesdYiNAsflh..............aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke

EFGEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQM
..||.|.|....  .  .  . | | ..|..  |.. ....  |.. .... |. .... .. |.. |... |.||...||. .|||  |.|  . ....
tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpe.natsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlerv

KSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTSA
| ..||||||.|| .|.. ||||| . ||. |...   ... |.. .
kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 720-1036 5.4e-58 191.4 In-house 5-314 (315) alignment 
Range on Protein: 720-1036
Range on HMM: 5-314/315.0
RIPLEEFGQYVNNLRNNNNKLFREQFKRLGVPDL-PTDIASSDENKPFNRNQNIVPYDVNIIELePLPRfLDCQHTYVNASYIMVNkddEQGQKYIATQG
 |||...  || . . . .. |..... .   .| | |.|   |||  ||  ||..||   ..| ||    | .  ||||..|      .. ..|||.||
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvql.plle.ndphsdyvnanfidGy...nkkrryiaaqg

PLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRgSEDYGPFTVTLQKETTSNSFIIRELTLhVSGSAQSTllITHYQFIDWLEYGPQPPIN
|.  .| ||||.|..|.   |||||.| |. . |. .||| .    ||..|||...|   . . .| |.  |.|.   .  .  ...  | . |      
pnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsv.vfgdnire..vvqlhytswpdmgvpkyti

SLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAA-CDLQST
.|... . .    . . |.|||||| | ||||.|| ... .. | .| .||.  ..| .|..|. |.|...|| ....|.||  .|||| ||    ||. 
plmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqry

ISSLSSSDNASVTGFEAQF
 | |. | ..  | .. ||
dsllapspdtgstllqeqf
subfamily_PTPN12_pd Subfamily PTPN12 752-1000 5.2e-56 184.7 In-house 29-275 (290) alignment 
Range on Protein: 752-1000
Range on HMM: 29-275/290.0
DLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFLdcQHTYVNASYIMVNKDDeqgQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRI
  .|. ....||.  || ..|.||| . .||.        .  |.||..|   ...   ..|||.|||| .|. |||||.|. .   .||. .. |  ..
vysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegk...leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

KCSQYWPSRGSEDY--GPFTVTLQKETTSN-SFIIRELTLHVSGSAQStllITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGR
|| .|||..| |.   |.|.|||..| . .  |.|| |......  ..   .. ... .| . |    ..||... . . .  |... |.||||| | ||
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrk...vyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGr

TGAFIGMSCSIKDALTESI---IDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
||. | .    .   .| |   .|.  .|. .|.||  ..|| .|| ||..||.|
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
0050432 (Phosphotyrosine protein) phosphatases II 1085-1325 6.2e-56 185.3 In-house 79-305 (308) alignment 
Range on Protein: 1085-1325
Range on HMM: 79-305/308.0
VADQWRVHLkSESPDYINAVFIPVLIinlyviflssqsYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE---GTIEF
  |. ||.| .|. ||||| .... .            .|... ||..|.|| .|  |||.|... ....||||  ..| . | |||||| |   |..|.
pydhsRVkl.degsdYInAsyvdgys............sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsley

GEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITsCNEGAIINTMNLVKTLQrksPNTPVLMHCSNMIGRSAVFCAAMATVDQMKS
| ||. ...|  .... .  | ..|....  |.. ||.  .| ....   .  .... ..||.. .   |. |.. |||. .||...|.|.   ..|.. 
gkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvP.pspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlek

SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTS
   ||||..|| .|   ||.||.. ||. .. ... |..|. | 
eggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
0036941 (Phosphotyrosine protein) phosphatases II 1085-1322 9.9e-56 184.6 In-house 50-280 (297) alignment 
Range on Protein: 1085-1322
Range on HMM: 50-280/297.0
VADQWRVHLKSESPDYINAVFIPvliinlyviflssqSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFG
  |. ||.|..|. ||||| ...               |. .. ||..| || .|  |||.|...  .|.||||.. .| . | |||||| |  .....|
pydhtRVklddegsdYinAsyvd..............gydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltyg

EFTISVREEWG--HQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKS-PNTPVLMHCSNMIGRSAVFCAAMATVDQM
.||. ....    .... .  | | ...|.  |.. ||.. ||  ... . .   ... ..||.. .... ...||| |||. .|||..|.||   ..|.
dftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe.spaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqql

K---SSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLF
.       ||....|| .|   |||||. .||. .. . . ... .
edklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 766-1000 1.1e-55 183.7 In-house 31-266 (274) alignment 
Range on Protein: 766-1000
Range on HMM: 31-266/274.0
FNRNQNIVPYDVNIIELEPLpRFLDCQHTYVNASYIMVnkDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG----
 || ..|.| .   . ||.     | . .|.|| ||     ||. . |.||||||  || |||||..||..  |||||||.|  . ||..|.| .     
knryktilPnensrvllese.ssededssyinanyikG..ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

SEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQStllITHYQFIDWLEYGPQPPINSLVKFNKIISN---QTEHKKGPIVVHCSTGGGRTGAFIGMSCS
|| || . .. .| .. | . .|.|.|. . . .|   ..|| . || .      .|.|... . ...   ....| .|.||||| | ||||.||..| .
serygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

IKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
...   |...|.  .|. .| .|  |.|| .|| |.|.|. .
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
0051299 (Phosphotyrosine protein) phosphatases II 1084-1319 5.5e-55 182.2 In-house 59-286 (288) alignment 
Range on Protein: 1084-1319
Range on HMM: 59-286/288.0
IVADQWRVHLKS----ESPDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTI
.  |..||.|..    |. ||||| .|              . |.... ||..| || .|  |||.|... ....|||| ...| . | |||||| .|..
lpydhsRVkLsvldgvegsdYinAsyi..............dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsl

EFGEFTISVREEWGHQSFSRKLLLVRNN----KNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRkSPNTPVLMHCSNMIGRSAVFCAAMAT
..|..|.  ..|  ....    | |.|.    ...  |.  ||.. .| .... . .  .... ..||.. .. |.. ||. |||. .||...|.|.   
tygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd.spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdll

VDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
..|..   .|||...|| .|   ||.||.  ||.... ... |.
leqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN14_pd Subfamily PTPN14 755-999 1.8e-54 179.8 In-house 41-293 (300) alignment 
Range on Protein: 755-999
Range on HMM: 41-293/300.0
TDIASSDENKPFNRNQNIVPYDVNIIELEPLPrflDCQHTYVNASYIMVNKDDEQgQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCS
.. |. .||.. || ....||. | .|| |     . .. |.||| | |    .. ..||..||||. || |||.|||...   |||||. .|| . |. 
lstaklpenaeknrfkdvlPyednrvelsptk...enstgyinassikvsvggke.rsyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

QYWPSRGS----EDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTlLITHYQFIDWLEYGPQPPINSLVKFNKII----SNQTE-----HKKGPIVVH
.|.|. .|     ..| | || .  ..|.|.| . |.|.   | .    . | |..|| . |  . ... ... . .     . ..     ..| |..||
kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeer.tvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvh

CSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVL
|| |.||||  |     |.   ..  |||. |....|||||...||| ||  |.....
CsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_PTPN13_pd Subfamily PTPN13 751-1000 2.3e-54 179.5 In-house 25-267 (273) alignment 
Range on Protein: 751-1000
Range on HMM: 25-267/273.0
PDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRfldcqhtYVNASYIMVNKDDEQgQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLR
| . .... ..|||  || .|..|||   ..|.           |.|||.| |. ....  .|||.||||  || |||.|||. ||  |.|.|. .|. .
pldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkde.yeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk

IKCSQYWPSRGSED---YGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTlLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEhKKGPIVVHCSTGGG
.|| .|||.. ..    .. ..|.| | .  ..| .|.|... | |..|   ..| .|..| ..|     ..|..| . . .  . ..||||||||.| |
vkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesr.evahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiG

RTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
|.|..| .   .     .  .|.  .|  .||||  ..|| |||..|..|.||
rsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_PTPRD_pd Subfamily PTPRD 1087-1326 4.6e-54 179.0 In-house 61-288 (564) alignment 
Range on Protein: 1087-1326
Range on HMM: 61-288/564.0
DQWRVHL----KSESPDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFG
|. || |    . |. ||||| ||              ..|...| .| .| || || .|||.|.......|||||. . | ... |..|||..|| ..|
dhsRVvLskvegdegsDYINAsfi..............dgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetyg

EFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLQrKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSS
|.|... ||   . .. . . ....|..  |   .|.   | . ..      .... .. |..|. .. . |.. |||. .||. .|..  | ....|..
eltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa.tslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikee

SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTSA
 .||..|.||..| . .  ||.. ||  ||.  . ... ..|. 
ktvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntev
0040438 (Phosphotyrosine protein) phosphatases II 1084-1322 1.1e-53 177.9 In-house 53-279 (317) alignment 
Range on Protein: 1084-1322
Range on HMM: 53-279/317.0
IVADQWRVHLKSES----PDYINAVFIPvliinlyviflssqSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTI
.  |. ||.|....     ||||| ...               ..  . ||..|.|| .|  |||.|...  .|.|||| . .| . | |||||| ..|.
lpydhsRVkLsplggdldsdYInAsyvd..............gpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetl

EFGEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRkSPNTPVLMHCSNMIGRSAVFCAAMATVDQM
..|.||. ...|  ....    | | .....  |.. ||.  ||  ... . .   ... ...|.. .. .|..||| |||. .||...|.||   ..|.
tygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp.spdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleql

KSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLF
.    |||...|| .|   |||||. .||. ...... |.. .
ekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
Y_phosphatase Protein-tyrosine phosphatase 1084-1315 1.3e-53 177.2 Pfam-A 11-233 (235) alignment 
Range on Protein: 1084-1315
Range on HMM: 11-233/235.0
IVADQWRVHL-KSES-PDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWP--KEGTI
...|. ||.| .||.  ||||| ..              ..||..| ||..| || .|  |||.|........||||   .| ..|.||||||  .|.. 
lpydktrvklkgsegpsdYInAnyv..............kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EFGEFTISVR--EEWGHQSFSRKLLLVRNNKNN-MLRRLAHFQVDGWSNDDITSCNEGAIiNTMNLVKTLQrKSPNTPVLMHCSNMIGRSAVFCAAMATV
..|.... ..  |.  ....  . | ....|..   |.. .... .| . .. ..... . .... |.. . .. ..||. |||. .||...|.|... .
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll.dlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldill

DQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLA
.|... . |||.|.||..| . ||.||.  ||.... . 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1084-1315 1.3e-53 177.2 In-house 11-233 (235) alignment 
Range on Protein: 1084-1315
Range on HMM: 11-233/235.0
IVADQWRVHL-KSES-PDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWP--KEGTI
...|. ||.| .||.  ||||| ..              ..||..| ||..| || .|  |||.|........||||   .| ..|.||||||  .|.. 
lpydktrvklkgsegpsdYInAnyv..............kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EFGEFTISVR--EEWGHQSFSRKLLLVRNNKNN-MLRRLAHFQVDGWSNDDITSCNEGAIiNTMNLVKTLQrKSPNTPVLMHCSNMIGRSAVFCAAMATV
..|.... ..  |.  ....  . | ....|..   |.. .... .| . .. ..... . .... |.. . .. ..||. |||. .||...|.|... .
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll.dlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldill

DQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLA
.|... . |||.|.||..| . ||.||.  ||.... . 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0046845 (Phosphotyrosine protein) phosphatases II 1085-1324 2.6e-53 176.6 In-house 39-279 (284) alignment 
Range on Protein: 1085-1324
Range on HMM: 39-279/284.0
VADQWRVHLKS-----ESPDYINAVFIPVLIINLYviflssqsyKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG-T
. |..||.|||     |. ||||| ....  ..|.         .. | ||..| || .|  |||.|... ....|||| ...| . | |||||| || .
pydhsRVklksldgdledsdYinAsyvdgydldlt.........yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegev

IEFGEFTISVREEWGHQSFSRKLLLVRNNK-NNMLRRLAHFQVDGWSnDDITSCNEGAIINTMNLVKTLQRK-SPNTPVLMHCSNMIGRSAVFCAAMATV
...|.||. ...|. .... .  | ..|.. ..  |.. ||.. .|  |. .  .   ... ..||..|... ... |.. |||. .||...|.|..   
ltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp.dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdlll

DQMKSSS---VVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFST
.|..  .   .|||...|| .|   ||.||.  ||.... ... |..|. |
eqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_PTPN9_pd Subfamily PTPN9 725-1003 9.5e-53 174.1 In-house 5-291 (297) alignment 
Range on Protein: 725-1003
Range on HMM: 5-291/297.0
EFGQYVNNLRNNNnkLFREQFK-RLGVPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMVNKddeQGQKYIATQGPLDRT
|. .||.. ...   | .| .. |   .    . . .  |   || .... ||   . |. ..   | .  |.||...   |   | . .|||||||..|
elvayvkekgkrG..lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvde..deasdyinanfvdGyk...qkkafiatqGplkkt

VVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWP--SRGSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTlLITHYQFIDWLEYGPQPPINSLV
| |||||||....  ||| |.. |  |.||.||||  .  |...| ..|.  .  ... . .| |... .   .|   .||.||. | .||     .||.
vsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesr.kvthfqflsWPdyGvPssaasll

KFNKIISNQ------------TEH-KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQAL
.. . . ..            . | .. |||||||.| ||||.|| .  ...   ... .|.  .|  .|.||  .||| .||.. . |||| ||
dvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 762-1000 9.8e-53 173.8 In-house 2-237 (237) alignment 
Range on Protein: 762-1000
Range on HMM: 2-237/237.0
ENKPFNRNQNIVPYDVNIIELEPLprflDCQHTYVNASYImvNKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG
|||  ||  ||| || . . |.       ..  |.||.|.  .. |   .||||.||||. .  |||.||||||   ||||| | |  ..|| .||||  
enkiknrygnivaydhsrvvlkga....gsgsdyinatyl..kgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd

-SEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH--KKGPIVVHCSTGGGRTGAFIGMSCS
  . || .||.|.|.     . .| |.| . .. .   ||  |||  | . |      .|..| | | |...|  . || ..|||.| |||| |. . . 
qpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam

IKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
...|  . ..||   |  . |.|  .||| |||...|...||
lrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0047943 (Phosphotyrosine protein) phosphatases II 1085-1318 1.1e-52 174.6 In-house 49-271 (273) alignment 
Range on Protein: 1085-1318
Range on HMM: 49-271/273.0
VADQWRVHLKSESPDYINAVFIPVLiinlyviflssqsyKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG---TIEF
  |. ||.|.... ||||| ....               .  . ||..| || .|  |||.|...  ...|||| ...| . | |||||| ||   ....
pydhsrvklgdggsdyinAsyvdgy..............nlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelslty

GEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKS-PNTPVLMHCSNMIGRSAVFCAAMATVDQMK
|.||. ...|  ....    | ..|....  |   ||.. || .... . .   ... ..||.. ....  |.||. |||. .||...|.|.   .||..
gkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp.slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqle

SSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
    |||...|| .|   ||.||.  ||.... ... |
keggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_PTPN23_pd Subfamily PTPN23 757-1002 3.1e-52 172.2 In-house 37-280 (288) alignment 
Range on Protein: 757-1002
Range on HMM: 37-280/288.0
IASSDENKPFNRNQNIVPYDVNIIELEplprflDCQHTYVNASYImvNKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQY
|| .  .   ||...|.||| | . |.      . .  |.|||..  ..   .  ..||||.||. |. |||.||...|.  ||||.. .|  . |...|
iaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfv..kdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrY

WPSRGS--EDYGPFTVTLQKETTSNSFIIRELTLHVSGSaQSTLLITHYQFIDWLEYG-PQPPiNSLVKFNKIISN----QTEHKKGPIVVHCSTGGGRT
||..    . .|...|||....... .. |.|.|.. .. . .  ..| |.  | |.| |. | ..|..| . . .    . .. | |.|||||.| |||
wPedkgetvkfgdlsvtlksvretethvervlkletlda.davksvshlqltsWpelGvPasP.etllqfldevesayeavqrksktPlvvhCsaGvgRt

GAFIGMSCSIKDALT-ESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQA
|.|  . . ...  . . ..||. ||  .||||  |.|. .|.  . |||||.|
gvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 754-1024 3.3e-52 172.6 In-house 39-310 (325) alignment 
Range on Protein: 754-1024
Range on HMM: 39-310/325.0
PTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYImvnKDDEQGQKYIATQGPLDRTVVDFWRMV--WQekaCAIVMLTKLQEDLRI
   .|   |||  || .|.|..| . . || .    | .  |.||||.   .|| . . ..|.| ||  |. |.||.|  |.   |..|...   .    
akkvamkpenkaknrfknvvaldksrvvletkkd..dpssdyinasyl...rddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkd

KCSQYWPSR--GSEDYGPFTVTLQKETTSNSFIIRELTLHvsGSAQ-STLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEH------KKGPIVVHC
.|..||| .   |  .|.. | |.   .   .. | | .   .  .  |. .  .|.  | . | |    .|. . ... .  |         .||.|||
rcavywpkemgksktfGglevklrtieeisdyvhrvldvk..qvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

STGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQSTISSLSSS
|.| ||||.|| . . ..  ..|| .||  .|  .|..|  |..| |||.|..||. |  ..|.|..  . ... .|||   
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqer
0043336 (Phosphotyrosine protein) phosphatases II 1084-1318 2.4e-51 170.2 In-house 55-276 (278) alignment 
Range on Protein: 1084-1318
Range on HMM: 55-276/278.0
IVADQWRVHLKSES----PDYINAVFIPvliinlyviflssqSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPkEGTI
.  |. ||.|....     ||||| ...               |.  ..||..| || ||  |||.|...  .|||||| . .| . . |||||| .|..
lpydhsrvklsllggdldsdYinAsyvd..............gynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsl

EFGEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRkSPNTPVLMHCSNMIGRSAVFCAAMATVDQM
..|.||. ...|  .. . .  | | |....  |   |..  ||  ... . .   ... .. |.. .. ..|.||| |||. .||...|.|.   ..|.
tygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleql

KSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
..   ||....|| .|   |||||.  ||.... ... |
ekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 755-1000 3e-51 169.0 In-house 12-262 (270) alignment 
Range on Protein: 755-1000
Range on HMM: 12-262/270.0
TDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMvnKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCS
.|. .   .| .|| ..|.|  .  . ||.|    | . .|.|| |.     |.. .||||..|||. |. .||||.|.||. ||||.|.|.|. | ||.
sdlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvr..GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCe

QYWPSRGSE----DYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLlitHYQFIDWLEYGPQPPIN------SLVKFNKII-SNQTEHKKG-PIVVHC
.|||..  |     .|  .|. ..|. .. .|...|.|. .|. .  .   |... .| . |  .  .      .|.|  . .   ..|..|. |..|||
rYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv...HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

STGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
| | |||| .| .   ..   ... .|. |... .|..|| ..|. .|| ....||.|
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
DSPc_SM00195 1085-1319 5.3e-51 168.8 In-house 37-262 (263) alignment 
Range on Protein: 1085-1319
Range on HMM: 37-262/263.0
VADQWRVHLKSES----PDYINAVFIPVLiinlyviflssqsyKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GT
. |. ||.||.|      ||||| .| .               ...| .|..| || .| .|||.|........||||.  .| ..| |..|||.|  |.
pydhtrVklkkeekkegsdYINAnyikga..............nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggk

IEFGEFTISVREEWGHQ-SFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITsCNEGAIINTMNLVKTLQRKSpNTPVLMHCSNMIGRSAVFCAAMATVD
 .||.... ..|.  .. .. .. | .......  |.. ..|. .| . ..   ..  ... .. ||. ...| ..|.. |||. .||...|...   ..
etfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp.dstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiils

QMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
.... . ||.|..||..| . ||.||.. ||..|.. ...|.
kleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1085-1319 5.3e-51 168.8 In-house 37-262 (263) alignment 
Range on Protein: 1085-1319
Range on HMM: 37-262/263.0
VADQWRVHLKSES----PDYINAVFIPVLiinlyviflssqsyKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GT
. |. ||.||.|      ||||| .| .               ...| .|..| || .| .|||.|........||||.  .| ..| |..|||.|  |.
pydhtrVklkkeekkegsdYINAnyikga..............nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggk

IEFGEFTISVREEWGHQ-SFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITsCNEGAIINTMNLVKTLQRKSpNTPVLMHCSNMIGRSAVFCAAMATVD
 .||.... ..|.  .. .. .. | .......  |.. ..|. .| . ..   ..  ... .. ||. ...| ..|.. |||. .||...|...   ..
etfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp.dstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiils

QMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
.... . ||.|..||..| . ||.||.. ||..|.. ...|.
kleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0045450 (Phosphotyrosine protein) phosphatases II 1084-1318 2.3e-50 167.4 In-house 65-303 (307) alignment 
Range on Protein: 1084-1318
Range on HMM: 65-303/307.0
IVADQWRVHLKS-----ESPDYINAVFIPVLIINlyviflSSQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGT
.  |. ||.|.|     |. ||||| .. | ..         ..|.... ||..|.|| ||  |||.|...  .|.||||.. .| . | |||||| ||.
lpydhtRVklssldgsledsdYiNAsyvrvplll......lldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdege

I-EFGEFTISVREEWGHQSFSRKLLLVRNN-KNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKS-PNTPVLMHCSNMIGRSAVFCAAMAT
  ..|.||. ...|  .... .  | | .. .... |.. ||.  || .... . .   ... ...|.. .... ...||| |||  .||...|.||   
eltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp.sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

VDQMKSSSV---VDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
 .|...  .   ||....|| .|   |||||| .||. .. ... .
lrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1090-1325 3.8e-50 165.7 In-house 64-289 (305) alignment 
Range on Protein: 1090-1325
Range on HMM: 64-289/305.0
RVHLKSESP--DYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTI--EFGEFT
..  |.. .  ||||| ..              ..||. | .|.||.||..| .|||..|..  ..|||||. ..||... | ||||.. |   |||||.
iltekeslddsdyinasyv..............dgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefs

ISVREEWGHQSF-SRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSV
. ...|   . .  ||| .  .....  | . ..|.  | .. .     ..... .. |.  |.|. ..|.| |||. .||. ||.|    ....|   |
velksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpq.fatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEev

VDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTS
||||. .|..| . ...||.. ||  .|   . ... . ||
vdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdts
subfamily_PTPRN_pd Subfamily PTPRN 732-1001 2.5e-49 162.6 In-house 23-291 (297) alignment 
Range on Protein: 732-1001
Range on HMM: 23-291/297.0
NLRNNNNKLFRE--QFKRLGVPDLPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMvnKDDEQGQKYIATQGPLDRTVVDFWR
.  .|...| .|   ...    .  ...|....|   ||.....||| ....|.      . .. |.||| |.  ..| .   ||||||||  || |||.
dhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeas..aeksdyinasail..dhdprapayiatqgplastvadfwq

MVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKET-TSNSFIIRELTLHVSgSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIIS
|||.. .. ||.||.|.|.   .|..|||  ||| |. . | |  |   .. ...| . |     .. |  .| . |. | | |  .  .||..| . . 
mvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknl.qtsetrtvtqfhflswpeegvPasaksllefrrkvn

NQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALT-ESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
     .  ||||||| | ||||..| .   ..  |     ||| | .  .|.||  ...| ||. ..  || |.
ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
0039614 (Phosphotyrosine protein) phosphatases II 1084-1322 3.5e-49 163.2 In-house 66-292 (297) alignment 
Range on Protein: 1084-1322
Range on HMM: 66-292/297.0
IVADQWRVHLKSES-----PDYINAVFIPVLIInlyviflssqsykNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEeACAQYWPKEGT
.  |. ||.||.|       ||||| ....  .             ... ||..| || ||  |||.|...  .|.|||| . .| .   |||||| ||.
lpydhsrvklkpedgvdldsdYinAsyvdgydl.............ltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg

iEFGEFTISVREEWGHQSFSRKLLLVRNnkNNMLRRLAHFQVDGWSnDDITSCNEGAIINTMNLVKTLQRKS-PNTPVLMHCSNMIGRSAVFCAAMATVD
 ..|.||. ....  .. . .  | |.|  |.  | . |||. ||  |. .  .   ... ..||.. .... ...||| |||. .||...|.||   ..
.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwp.dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmle

QMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLF
|...   |||...|| .|   |||||. .||. .. ... ... .
qlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPN1_pd Subfamily PTPN1 752-1008 1.1e-48 160.4 In-house 21-279 (290) alignment 
Range on Protein: 752-1008
Range on HMM: 21-279/290.0
DLPTDIASSDENKPFNRNQNIVPYDVNIIELEplprflDCQHTYVNASYIMVNkddEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRI
|.||  |  .||.. || ... |||   |.||      . .  |.||| . ..   |  ..|| ||||| .||  ||.|||..|. |.||| |. |  .|
dfptreaklpenrnlnryrdvspydhsrikle......radndyinaslvele...eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

KCSQYWPSRGSE-----DYGPFTVTLQKETTSNSFIIRELTLHVSgSAQSTLLITHYQFIDWLEYG-PQPPiNSLVKFNKII--SNQTEHKKGPIVVHCS
|| ||||.  .|     .   ..|.| .| ... ...| | |.   ..| |  |.|. .. | ..| |. | ....||   .  |    ...|| |.|||
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenl.ktqetreilhfhyttwpdfgvpesp.aaflkflfkvresGslssdvGpavihcs

TGGGRTGAFIGMSCS---IKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQAL--CGDTQ
.| ||.|.|. . .    |..    | .||  |.  .|..|. .||| ||  . . |.|| |    ||. 
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdss
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 721-1030 2.3e-48 159.6 In-house 4-264 (392) alignment 
Range on Protein: 721-1030
Range on HMM: 4-264/392.0
IPLEEFGQYVNNlrNNNNKLFREQFKRLGVPDL-PTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFldCQHTYVNASYIMVNKDDeqgQKYIATQGP
||  .|  .|..  |  . || |.|. |  ||. |. .|  . |.. || .||.||| . . || .      .. |.|||||   . .   . |||.|||
ipvaqfpafvek..nrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddi..pdsdylnasyipsfdne...kayiasqgp

LDRTVVDFWRMVWQEKACAIVMLTKLQEDLrikcsqywpsrgsedygpftvtlqkettsnsfiireltlhvsgSAQSTLLITHYQFIDWLEYGPQPPINS
   .. ||||||.||....|.|.|||.|                                               ...  .. ..| .| . .     .|
naaslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtss

LVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQSTIS
|.|| | .. .  .   |...|||.| ||||  | . . .  | .  ..|.  .|| .|..| .|.|| .|| ... ||||. |  .| |    .   ..
llkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlq

SLSSSDNASVT
 ||.| .  |.
dlstssdGdvr
0042113 (Phosphotyrosine protein) phosphatases II 1085-1319 9.4e-48 158.1 In-house 20-243 (245) alignment 
Range on Protein: 1085-1319
Range on HMM: 20-243/245.0
VADQWRVHLKSES----PDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIE
  |. ||.|....     ||||| ..                |.  ..||..| ||.||  |||.|...  |||||||.. .| . . |||||| .....
pydhtrvklspdggdldsdyinasyv..............dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslt

FGEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSnDDITSCNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMK
.|.||. ...|  .... .  | | |....  |   |..  .|  |. .  .   ... ...|.. .....|.||| |||  .||...|.||   ..|..
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqle

SSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
.   |.....|| .|   |||||. .||. .. ... ..
kelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 724-1015 1.1e-47 157.5 In-house 5-292 (439) alignment 
Range on Protein: 724-1015
Range on HMM: 5-292/439.0
EEFGQYVNNLRNNNNKLFREQFKRLGV--PD--LPTDIASSDENKPFNRNQNIVPYDVNIIELEPLPRFLdcQHTYVNASYIMVNKDDeqgQKYIATQGP
.|| ..|..| .|....|.| |. ..   ||    . .|. . ... || ......|   . |. .|     .  |.|| ||    ||   . |||||||
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvp..hshyinanyikGyydd...klyiatqgp

LDRTVVDFWRMVWQEKACAIVMLTKLQEDLRikcsqYWPSRGSEDYGPFTVTLQKETTSNSFIIRELTLHVS-GSAQSTLLITHYQFIDWLEYGPQPPIN
 . |. ||||.|...|.  |||||.| |  .     |||| .   ||  .|  ...     ..|| . .     ...    . ....| | .        
kkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqas

SLVKF-NKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDTQIAACDLQ
 ...|   | | . ... ||.|||||.| ||||. | .  ....  .|  .||  .|...|.||  |.|.| ||.....||||.   ||. ..  ...
hvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefk
0040439 (Phosphotyrosine protein) phosphatases II 1085-1318 1.1e-47 158.2 In-house 22-245 (249) alignment 
Range on Protein: 1085-1318
Range on HMM: 22-245/249.0
VADQWRVHLKS----ESPDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIE
  |. ||.|..    .  ||||| .|                |.  . ||..| || ||  |||.|...  ||.||||.. .| . | |||||| .|..|
pydhsrvklsilpglflsdyinAsyi..............dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsle

FGEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSnDDITSCNEGAIINTMNLVKTLQRKS-PNTPVLMHCSNMIGRSAVFCAAMATVDQM
.|.||. ....  .... .  | . |....  |.  |.|. .|  |. .. .   ... ...|.. ...  ...||| |||. .||...|.||   ..|.
ygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql

KSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
.    ||....|| .|   |||||| .||. .. ... .
ekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1087-1323 2.2e-47 156.4 In-house 22-246 (250) alignment 
Range on Protein: 1087-1323
Range on HMM: 22-246/250.0
DQWRVHLKSES----PDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEaCAQYWPKEGTIEFG
|. || |..|.     |||||.|.              ..|.. | ||..|.|| .|  |||.|.......|||||. . | |.. . |||| |.. ..|
dssrvvLekekgdkesdyinasfl..............hgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

EFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSS
. |.|. ..  .  .  . | . ..|..  | . ...   | .  .   .  |... .. |.. |... |.||...||. .|||  |.|  | ....| .
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPe.vatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkke

SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFS
 |||||. .| .| . |.||. . || ......  ... ..
kvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 762-1000 4.4e-47 155.3 In-house 6-238 (239) alignment 
Range on Protein: 762-1000
Range on HMM: 6-238/239.0
ENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYImvNKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG
 ||  ||  ||| || . . || |    | .  |.||||.     |   . |||||| .  .  |||||.|||. | ||||| | |  . || ||||   
vnkaknryanivtydhsrvvleklsn..dphsdyinasyl..rdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SeDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTlLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKD
|  |  . |||.|      .||| . .   | ..    . .|.|  | . |      ... . . |....     | |.|||.| ||||||. . . ...
s.kycnlrvtlrktevfadyiirtfvmsqvgqteer.yvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

ALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
|  .  .||   |  .||.|  |.|| .||...| ||||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1087-1325 5.1e-47 155.5 In-house 61-289 (319) alignment 
Range on Protein: 1087-1325
Range on HMM: 61-289/319.0
DQWRVHLK----SESPDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFG
|. || |.    .|. ||||| ||              ..|.. . || .|.|| .|  |||.|....|. ..|||. . |  .  . .|||.|   |.|
drtrvvlseldgvegsdyinasfi..............dgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyG

EFTISVREEWGHQSFSRKLLLVRNNKNNM-LRRLAHFQVDGWSNDDITSCNEgAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKS
.... . ||   . .  . | ........  |.. |||   |...|.      .... .. ..  ..|. . |. .|||. .||   |..  |.....| 
rlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat.slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervke

SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNLFSTS
 .|.|||.||...|.  .  ||.. |||.|.    ..|. ..| 
egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 761-1000 5.8e-47 154.8 In-house 6-239 (239) alignment 
Range on Protein: 761-1000
Range on HMM: 6-239/239.0
DENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYImvNKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR
  ||  ||  ||| || . . || |    | .  |.||||.     |   . |||||| .  .  |||||.|||. | ||||| | |  . || ||||  
rvnkaknryanivtydhsrvvleklsn..dphsdyinasyl..rdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

GSeDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTlLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIK
 |  |  . |||.|      .||| . .   | ..    . .|.|  | . |      ... . . |....     | |.|||.| ||||||. . . ..
ts.kycnlrvtlrktevfadyiirtfvmsqvgqteer.yvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

DALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
.|  .  .||   |  .||.|  |.|| .||...| ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1096-1326 1.3e-46 154.1 In-house 72-287 (318) alignment 
Range on Protein: 1096-1326
Range on HMM: 72-287/318.0
ESPDYINAVFIPvliinlyviflssqSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQ
|. ||||| .|.               |...| .| ||.|| || .|||.|..... ..||||. ..|   . ...|||..|....|. .. ..||   .
egsDyinanyid..............GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevels

SFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMR
..  . . |......  |    ...  |.. .. . . . ... .  |.. |.|| ..|...|||  .||  ||.|  . ....|  ..||||||||..|
dyvlrefkvtrteeeesrqvrqyhytsWpdegvpe.sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlr

VNLPGAVQNKGQYKMIHTLAAAYVNLFSTSA
 . .  || . ||..|..    ... . | .
eqrnlmvqtedqyefiydvllealasgdtev
0045098 (Phosphotyrosine protein) phosphatases II 1085-1320 9.2e-46 151.8 In-house 44-273 (278) alignment 
Range on Protein: 1085-1320
Range on HMM: 44-273/278.0
VADQWRVHlksespDYINAVFIpvliinlyviflssQSYknDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEF
  |. ||.      ||||| .|              ..|  .| ||..| || .|  |||.|...  ||.|||| . .|.. | |||||| .|....|.|
pydhsrVk......dYINAsyi..............dgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

TISVREEWGHQSFSRKLLLVRNN----KNNMLRRLAHFQVDGWSNDDITSCN-EGAIINTMNLVKTLQR------------KSPNTPVLMHCSNMIGRSA
|. . .|  .. .    |||.|     .... | . |..  .|   .. | .    ... .. ..  ..             ....||| |||  .||..
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

VFCAAMATVDQMksSSVVDVFQTVKNMRVNLPG-AVQNKGQYKMIHTLAAAYVN
...||.   ...   ..||....|| .|   || ||||..||. .. ... ...
tlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPRA_pd Subfamily PTPRA 1096-1318 9.7e-45 147.9 In-house 84-294 (330) alignment 
Range on Protein: 1096-1318
Range on HMM: 84-294/330.0
ESPDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREEWGHQ
|. ||||| ||              . ||. . || || |..||  |||.||.... .|||||. . | .|| ||||||.||.. .|. ...|..|   .
eesdyinasfi..............dGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlv

SFSRKLLLVR----NNKNNMLRRLAHFQVDGWSNDDITSCNEGaIINTMNLVKTLQRKSPNtPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTV
... . .||.    . ...  | .. |   .| .  . .   | ... .. ||.|...| . |. .|||  .||.  |..  | ....|.  .||||..|
dytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG.mlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefv

KNMRVNLPGAVQNKGQYKMIHTLAAAY
|..| . |  || . ||..|.     |
krlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1086-1314 1.7e-44 147.0 In-house 59-274 (288) alignment 
Range on Protein: 1086-1314
Range on HMM: 59-274/288.0
ADQWRVHLKS----ESPDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGT-IE
 |. ||.||     .. ||||| .|              ...|..| .| .|.|| .|  |||.........|||||. ..||... | .|||....  .
yDekrvklkkleeeagaDYinasyi..............dgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpkn

FGEFTISVREEWGHQSFSRKLLLVRnnKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKSpNTPVLMHCSNMIGRSAVFCAAMATVDQMK
.|..|. ..|.   ..|  . ||.   |..  ... ..|  .|.....   ..  ... .. ||. . .    |...|||. .||. .| |. | .|...
yGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPe.skapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidave

SSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
.. ..||. ||...| . .  ||.. ||  |.  
eedyiDvagtvaklRkqRallvqtlkqYefiyev
subfamily_Ptp69D_pd Subfamily Ptp69D 1088-1319 4.6e-44 145.8 In-house 62-286 (307) alignment 
Range on Protein: 1088-1319
Range on HMM: 62-286/307.0
QWRVHLK----SESPDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFGE
. || ||    .|. ||||| ||              ..||. | ||.|| |. .|  |||.|| . |.|.||||| . | ... ||.|||.| ....|.
ktRvkLkkingkedsdYinasfi..............kgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygd

FTISVREEWGHQSFSRKLLLVRNNKNNM-----LRRLAHFQVDGWSnDDITSCNEGAIINTMNLVKTLQRKSpNTPVLMHCSNMIGRSAVFCAAMATVDQ
  . . .|  |. . .. | | ..|..       |..  ..  ||  | .      .... .. |. |.... ..|...|||.  |||..| |    ..|
ilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqq

MKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
.|    ||.|.|||..| . .  ||.  ||. ..   . | 
lkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_CG7180_pd Subfamily CG7180 760-1006 1.1e-43 144.0 In-house 39-294 (296) alignment 
Range on Protein: 760-1006
Range on HMM: 39-294/296.0
SDENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYIMVNKddeQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRiKCSQYWPS
  ||.  ||. ..|||| | . || |    . .  |.||.|.       . ..|| |..| ..|| .|||.|..|.. |.|.|||  .  . .. .||| 
rkenreknrdvkvvPyDynRvvLekldG..eeksdYinavyvdsfl...kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpn

RGSEDYGPFTVTLQKETTSNSFIIRELTLHVS---------GSAQSTLLITHYQFIDWLEYGPQPPI-NSLVKFNKIISNQTEH-----KKGPIVVHCST
.. |.||.. | . .| .   . ||.. |            .    | .....|.  |      | . |.|... . .    |.     ..||.||..| 
kskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssd

GGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGD
|..|.|.....  ..  .  |  .|.   |  .|..|  .... ..|. . . .||  ||. 
GasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
0051429 (Phosphotyrosine protein) phosphatases II 794-1001 3.2e-42 140.4 In-house 5-224 (272) alignment 
Range on Protein: 794-1001
Range on HMM: 5-224/272.0
TYVNASYIMVNKDDEQGQKYIATQGPLDRTVVDFWRMvWQEKACAIVMLTKLQEDLRIKCSQYWP------------SRGSEDYGPFTVTLQKETTSNSF
.|.||...  .       ......|||. |. ||||. ....  .||.|... |  | ||..|||            |  .  || ..|||..|.. . .
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

IIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPInsLVKFNKIISNqtehkKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIID--------IPAV
|.|||.|.   ||. .. ..|....||. .|  .    |... ... .     .||..|||| | .||| .. .  .. .   | |.|        . ..
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VTIMREQRMMMIQTLDQYMLVHEAVLEQ
|  .|.||. ..|| .||. ..||.|| 
veelraqrpgavqteeqylflyeallel
subfamily_PTPRB_pd Subfamily PTPRB 1088-1315 2.3e-41 136.8 In-house 65-281 (293) alignment 
Range on Protein: 1088-1315
Range on HMM: 65-281/293.0
QWRVHL----KSESPDYINAVFIPvliinlyviflssqSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE-GTIEFG
. ||.|    .... ||||| .||               |.  . || .| || ||. |||.|..... ..||||  ..|.  . | .|||..  .. .|
hsrvkLaalkdesgsDYinanyip..............gynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyG

EFTISVREEWGHQSFSRKLLLVRNnkNNMLRRLAHFQVDGWSNDDITSCNEgAIINTMNLVKT-LQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKS
. .... .|   . .  . |....  ... |.. ...   |.. .. .  . .... .. |.. ..... ..|...|||  .||. .| |    ......
dikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektk.tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee

SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLA
. .||.| .| ..| .    ||.. || .||.  
edyvdifgivaelReeRnllvqtekqYifihqcv
0041856 (Phosphotyrosine protein) phosphatases II 763-1007 2.4e-41 136.7 In-house 1-176 (182) alignment 
Range on Protein: 763-1007
Range on HMM: 1-176/182.0
NKPFNRNQNIVPYDVNIieleplprfldcQHTYVNASYIMVNKDDEQgqkYIATQGPLDRTVVDFWRMVWQEKACAIVMLTklqedlrikCSQYWPSRGs
|.. || ..|.||| ..              .|.||.... .  . .   .|||||||..|| ||.||.....  .||.||         . .|||..  
nldknrysdilpydhsr............dldyInanlylgslpatr...fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.

edygpftvtlqkettsnsfiireltlhvsgsaqsTLLITHYQFIDWLEYGPQPpINSLVKFNKIISNqtehKKGPIVVHCSTGGGRTGAFIGMSCSIKDa
                                  . |...|... |  .|. . ...|..| ... .    ..||..|||| | ||||.....   .|  
..................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.

lteSiIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQALCGDT
   . .... .|  .|..|..|..|..|| ... |.||  |...|
...g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
0037934 (Phosphotyrosine protein) phosphatases II 1085-1317 3.4e-41 136.8 In-house 21-240 (243) alignment 
Range on Protein: 1085-1317
Range on HMM: 21-240/243.0
VADQWRVHLksESPDYINAVFIPVLiiNlyviflssqsykndkGFIIAQSPLRETRRD----FWKMIFDREITTIVMLSPIMEGEEEACAQYWPkeGTIE
  |. ||.|  |. ||||| .|.|.  .               ..|. | || ||  |    ||.|...  ||.|||| . .| . | ||||||  |...
pydhsrvkl..egsdyinanliyvt..p...............rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevt

FGEFTISVREEWGHQSFSRKLLLVRNNK-NNMLRRLAHFQVDGWSndDITSCN-EGAIINTMNLVKTLQRK-------SPNTPVLMHCSNMIGRSAVFCA
.|.||. . .|  ....    ||..| . ..  |   |..  .|   | .  .    ... .. |.. ...       ... ||| |||  .||.....|
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp..dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

AMATVDQMkssSvVDVFQTVKNMRVNLPG-AVQNKGQYKMIHTLAAA
|    ...   . ||....|| .|   || |||. .||. .. ... 
aylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPRK_pd Subfamily PTPRK 1087-1314 6.6e-41 135.1 In-house 56-272 (314) alignment 
Range on Protein: 1087-1314
Range on HMM: 56-272/314.0
DQWRVHLKS---E-SPDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIeFG
|. || |..   . | ||||| .|               |||. . ||..| ||.|| .|||....| . ..||||. ..|     | .|||..... .|
drsrvflitidgdpssdyinaali..............dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.yg

EFTISVRE-EWGHQSFSRKLLLVR-NNKNNMLRRLAHFQVDGWSNDDITsCNEGAIINTMNLVKTLQRKsPNTPVLMHCSNMIGRSAVFCAAMATVDQMK
.. . . | |   .  .| . . . . . .  | . .||  ||.. |.  ... .... .  ||. | .  . ....|||.  ||. .|.|    .| ..
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvP.vsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmie

SSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
  .|||||..||..| . .  |. . |||.|.  
regvvdvfnavktlrsrkvnmveteeqykfiydv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1121-1315 1.8e-40 133.7 In-house 81-273 (315) alignment 
Range on Protein: 1121-1315
Range on HMM: 81-273/315.0
QSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK--EGTIEFGEFTISVRE-EWGHQSFSRKLlLVRNNKNnmLRRLAH
.|...|| .| .| ||. .  |||.|... ..|||||..   ||.   |.||||.    ..|||.. ... . |   .   |||  .|. ..   |... 
ksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrksee..srtvtq

FQVDGWSNDDITScNEGAIINTMNLVKTLqRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLA
||  .| .  .   . ..... .  ||.  ... . ..|.|||  .||. |.....  |.|.| ...||||..|||.| . |  || . .| .|.   
fqftewPdkGvdk.qtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 766-999 9.5e-40 131.2 In-house 41-274 (287) alignment 
Range on Protein: 766-999
Range on HMM: 41-274/287.0
FNRNQNIVPYDVNIIELEPLPrflDCQHTYVNASYIMVNKDDEQgqkYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE-D
 ||  ...|.| . . |   .   .    |.|| |.   .|||.   .||.|||.  || ||||.|...........|.  |. | || .||| |     
knryadvlPiddtrvllsaeg...elGsdyinanyvasytddea...fiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmr

YGPFTVT-LQKETTSNSFIIRELTLHVSgSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKII-----SNQTEHKKGPIVVHCSTGGGRTGAFIGMSCS
 | ..|. |...  .  . .| | |     .. . ..  .....| . .  |   .|..|   .      ..   . ||.|||...| ||.| .. .   
vGGysvvlldydikePeygvralrlidl.etrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

IKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVL
..  .    .|. |||  .||.|  ..|.  |. |. ||. 
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1090-1318 1.5e-39 130.9 In-house 67-283 (297) alignment 
Range on Protein: 1090-1318
Range on HMM: 67-283/297.0
RVHLKSE----SPDYINAVFIPVliinL-YviflssqsykndkGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEeACAQYWPKEGTIEFGEF
||.|..     . ||.|| |...      .              .|  | | ..|  |||.|..| ...|||||.   |...  ||.||...|. .||. 
RvkLaivnddpdsDyvnasfvkg....nkh.............rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdv

TISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITS-CNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSS
.. .      . |... | |...|. . | .  .|   | ....    .  .... .. |.    .  ..|.|.||.. .|| .|...    | ..|   
svvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrek

VVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
 ||.|..|| .| . |  || | |||... .   .
evdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_PTPN3_pd Subfamily PTPN3 1087-1313 7.4e-39 128.3 In-house 54-270 (280) alignment 
Range on Protein: 1087-1313
Range on HMM: 54-270/280.0
DQWRVHLKSESPDYINAVFIPVLIinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE-GTIEFGEFT
|. ||.||... ||||| .. . |          .| .  . .|..| ||..|  |||.|........||||  ..|     | ||||..  ..|.|||.
datrvklkesetdyinanyvnmei..........pstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefs

ISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLqRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVV
. ...|  ..|.  . |........  |.. ..|   |.. .. . .   ... .. |..| |.. ..||..|||  |||. |. .   ..  . ..  |
vkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdds.adflefvervrkl.rsgkeePvvvhCsaGigrtGvlilletalalieaaepv

DVFQTVKNMRVNLPGAVQNKGQYKMIH-T
 . . |..||      ||...|||..  .
ypldivrtmrdqramlvqtasqykfvCea
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1120-1320 8e-39 128.4 In-house 67-269 (274) alignment 
Range on Protein: 1120-1320
Range on HMM: 67-269/274.0
SQSyKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTI----EFGEFTISVREEWGHQSFSRKLLLVRNNKNnmLRRL
  . ...| .. .| || .|  |||.||. .|.. ||||  . | .|. ||.|.|..  .    ..|.. | |..   .. .| . |.... ..   |..
Gyd.eeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersv

AHFQVDGWSnDDITSCNEGAIINTMNLVKTLQRK--SPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
 |.    |  |  .  .  ....... |.. ...   . .||..|||  |||  .| |.  .| |.. ..||||...| |.|..  | ||.. ||..|| 
khywytdWP.dhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihr

LAAAYVN
  . |..
alclylk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1121-1327 1.7e-38 127.0 In-house 79-301 (301) alignment 
Range on Protein: 1121-1327
Range on HMM: 79-301/301.0
QSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK--EGTIEFGEFTISVREEWGHQSFSRKLLLV--RNNKNN------
..|.. | ||.||.|...| .|||..|..   ..|||.    || .. | ||||.  . . |||.||. . .|  . .|  . | |  ..  ||      
dgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierk

-------MLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQ
         . .  .||  | .| .   .   ... .. |   |.|    ||. |||. ..|| |.|.   ...| |.  |||||| .| .| . ||||.
fkvksdksswdvlqlqvtdWpqdGvvr.eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVt

NKGQYKMIHTLAAAYVNLFSTSAN
   || .|.     |..| || ||
TLeqytsiydvidmylqlnstyan
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1121-1314 5e-38 125.4 In-house 80-271 (515) alignment 
Range on Protein: 1121-1314
Range on HMM: 80-271/515.0
QSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK--EGTIEFGEFTIS-VREEWGHQSFSRKLLLVRNNKnnmLRRLAH
.|..||| .| .| |.. .  |||..... ..|||.|..   ||.   |..|||.    ...||.. .. |  |   .   ||| ......    | .. 
psfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtq

FQVDGWSNDDITSCnEGAIINTMNLVKTLQRKSPnTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
|.  .| .  .      ...  .  ||. . .    |...|||  .||  |.....  | ..| . .||||..|.|.| . |  || . || .|.  
fhfteWPdkGvpkh.tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiyga
subfamily_PTPN9_pd Subfamily PTPN9 1121-1314 5.5e-38 125.7 In-house 79-285 (297) alignment 
Range on Protein: 1121-1314
Range on HMM: 79-285/297.0
QSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWP--KEGTIEFGEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHF
. ||. |.|| .| ||..| .|||.|....|. .|||   ..|     |.||||  .| ..|||....|. |   .. .  . | ..| |..  |.. ||
dGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthf

QVDGWSNDDITScNEGAIINTMNLVKTLQR------------KSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKG
|. .| .  . | .  .... .. |.  |             .  . |...|||  |||.  |..   ....... ..|||..||| .|     ..|   
qflsWPdyGvPs.saaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpe

QYKMIHTL
||.. .  
qyefcyla
subfamily_PTPRG_pd Subfamily PTPRG 1084-1313 2.5e-37 123.3 In-house 57-281 (563) alignment 
Range on Protein: 1084-1313
Range on HMM: 57-281/563.0
IVADQWRVHLKSES-----PDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGT
.  |. ||.|.. .      ||||| .|              . |.  | ||..| ||..|  |||.||.... ..|||.. . | . . | .||||...
vaydrsRvklsplpgkkkklDYinAnyi..............dGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdes

IEFGEFTISVREEWGHQSFSRKLLLVRN-----NKN-NMLRRLAHFQVDGWSNDDITSCNegaiINTMNLVKTLQRKSP--NTPVLMHCSNMIGRSAVFC
...|....   ||  . . . . | ..|     .|. .  ..  ...   | . .  . .    .  .. ||  ..  .    |...|||. .||. ...
etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs....lpvLifvkkssaankaeaGPivvHcsaGvgrtGtyi

AAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
.  . . |... ..|.||...| .| . .  ||.. ||  .| 
vldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhd
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1122-1318 2.6e-37 123.7 In-house 86-287 (325) alignment 
Range on Protein: 1122-1318
Range on HMM: 86-287/325.0
SYKNDKGFIIAQSPLRETRRDFWKMIFDREiTTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQ
..|. . |. ||.|| .|  |.|....| . ...|..  ....... ||.|||||   . .|| . ...|       .  . | |.. |.   | .  ||
ddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfq

VDGWSNDDITScNEGAIINTMNLVKTLQRK-----SPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
. .| .         ..|. ..|||... .        ||.|.|||. .||. || .  . ....   | ||.|. ||..| . |  |.   || .|.. 
lqswddmGvqk.rpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyea

AAAY
 . .
lvea
0046846 (Phosphotyrosine protein) phosphatases II 789-1000 2.7e-37 123.6 In-house 8-171 (176) alignment 
Range on Protein: 789-1000
Range on HMM: 8-171/176.0
LDCQHTYVNASYIMVNKddeqgqkYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYgpftvtlqkettsnsfiireltl
||   .|.||..|. ..       .||||||| ||. ||..|.....  |.|.||...|  |.|| .|||   ....                       
ldldldyinanlilgsr.......piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

hvsgsaqstllitHYQFIDWLEYGPQPPiNSLVKFNKIISNQTEHKkGPIVVHCSTGGGRTGAFIGMScsikdaLTES--IIDIPAVVTIMREQRM-MMI
             .|....| ..|. .  . | .. ..| .. ... ||..|||| | ||||... .       | |.   ...  ..  .||||. ...
.............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay......llelekglsveealalvreqRplgav

QTLDQYMLVHEAVLE
|| .||  ..|..|.
qtpeQyrflyefell
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1097-1314 3.6e-37 123.0 In-house 76-274 (315) alignment 
Range on Protein: 1097-1314
Range on HMM: 76-274/315.0
SPDYINAVFIPvliinlyviflssqSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEgTIEFGEFTISVREEWGHQS
  ||.|| ||.               |.  . .| ||.|. .. .|||...|. .|..||||. ..|||.. . .||| .  . .|..|.. ..|  .. 
hsdyvnanfid..............Gynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnte

FSRKLLLVRNnkNNMLRRLAHFQVDGWSNDDITSCNegaiINTMNLVKTLQ---RKSPnTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKN
.. . | |    .. .| .  ...  | . ...       |. |||..| .    .|  .....|||. .||.  |..  | .||..   ..||.. ...
ytvrtlsvvf..gdnirevvqlhytswpdmgvpkyt....iplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitg

MRVNLPGAVQNKGQYKMIHTL
.| |  ..||   ||..|.  
vrqnrikmvqvaeqyqfiyda
subfamily_CG7180_pd Subfamily CG7180 1120-1319 1.4e-36 120.6 In-house 78-290 (296) alignment 
Range on Protein: 1120-1319
Range on HMM: 78-290/296.0
SQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEeACAQYWPKEGTIEFGEFTISVREEWGHQSFSRKL-LLVRN---------NKN
 .|.  .| .|. . | .||  .||....|.|| ..|.|.  .. ..  . .|||...  ..||. . . ||     .  .   |...         . .
vdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvk

NMLRRLAHFQVDGWSNDDITSCNEGAIINTMNLVKTLQRKS----PNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNK
   | . .||.  |  .|       |.|. .. |.....|      . ||....|.  .|| |..|. |......    ||||. || .| . |. |.|.
aetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenv

GQYKMIHTLAAAYV
 .|| |  .   .|
eeYkyiYdvlleav
subfamily_PTPN23_pd Subfamily PTPN23 1086-1313 2.1e-36 120.2 In-house 55-274 (288) alignment 
Range on Protein: 1086-1313
Range on HMM: 55-274/288.0
ADQWRVHLKSESPDYINAVFIPVLiinlyviflSSQSYKndkgFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGE
 |. ||.|...  ||||| |.  |         |... .    ||..|.||..|  |||.|....   .||||    | ... ...|||..   | .||.
yDhnRvklrgskDDYinAsfvkdl.........spgcPd....fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd

FTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITSCNEgAIINTMNLVKT---LQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMK
........   . .... | .. ....  . . | |.  |..  . .  |  ... .. |..    ...  .||...|||  .||. ||.  .| | ...
lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPe.tllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrele

S-SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
    ..|. | |. .| .    ||.| |.|.   
kgnglldiiqvvsrlreqRrfmvqekeqlkfsye
0036282 (Phosphotyrosine protein) phosphatases II 794-996 2.7e-36 120.2 In-house 3-164 (174) alignment 
Range on Protein: 794-996
Range on HMM: 3-164/174.0
TYVNASYIMVNKDDEqgqKYIATQGPLDrtvvdFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSrgsedygpftvtlqkettsnsfiireltlhvsGS
.| |||.. ..   .   ..||.||||.     ||.|.....  ..|||....|. . || .|||.                                 .
dyinaspldlsyitp...rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lr

AQSTLLITHYQFIDWLEYGPQPPINsLVKFNKIISNQTEH-KKGPIVVHCSTGGGRTGAFIGMSCSIKDALtESIIDIPAVVTIMREQRMMMIQTLDQYM
   . |. .|... |  .|. .    | .| |.. .  .. ..||..|||| | ||||.....   ..  | || .|. ..|  .| ||..|.|| .||.
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

LVHE
 ...
flyy
subfamily_PTPN12_pd Subfamily PTPN12 1121-1319 5.9e-36 118.8 In-house 77-277 (290) alignment 
Range on Protein: 1121-1319
Range on HMM: 77-277/290.0
QSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEFTISVRE-EWGHQSFSRKLLLVRNNknNMLRRLAH
.  .... .| ||.|| .|  |||.||.. ... .||.  ..| .   |..|||.|   ..|||||.... | .. .. |  . | |...  .  |..  
kgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyq

FQVDGWSNDDITSCnEGAIINTMNLVKTLQRkSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSV---VDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
|.   | . .. |  .  ... ..||..||. | ..|...|||  .||  . .|   . ...|.  .   .|||. | ..| . . .|| | ||....  
fhYtaWPDhgvPss.aksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvyka

AAAYV
 | .|
vaelv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1096-1313 1.2e-35 118.4 In-house 87-285 (319) alignment 
Range on Protein: 1096-1313
Range on HMM: 87-285/319.0
ESPDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSpimegeEEACAQYWPKEGTIEFGEFTISVREEWGHQ
|  ||||| |.              . |.. . .| || || .|  |||.||.. ...|||.|.      .. |.||||... |. ..| ..|      .
efsdyinasfv..............tGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveeta

SFS-RKLLLVRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLQRK-SPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKN
 .  |.. | .. |..  |..  |   || .          ..  .. |. |..|   ......|||  .||. |. .  . .|.||  . |||...|..
eyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp.sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrd

MRVNLPGAVQNKGQYKMIHT
.| . .  ||.  |||.|..
lrqqrntlvqdlvqykfiys
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1096-1313 2.1e-35 117.6 In-house 51-249 (284) alignment 
Range on Protein: 1096-1313
Range on HMM: 51-249/284.0
ESPDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSpimegeEEACAQYWPKEGTIEFGEFTISVREEWGHQ
|  ||||| ||              . |.. . .| .| || .|  |||.||.. ...|||.|.      .. |.||||... |. ..| ..|      .
efsdyinasfi..............tGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveese

SFS-RKLLLVRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLQRK-SPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKN
 .  |.. | .. |..  |..  |   || .      .   ..  .. |. |..|   ......|||  .||. |. .  . .|.||  . |||...|..
eyvvrdielsedgkekdirkirqfhflgwpdvgvpdyp.sdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrd

MRVNLPGAVQNKGQYKMIHT
.| . .  ||.  |||.|..
lrqqrntlvqdlvqykfiys
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 760-1002 2.7e-35 116.7 In-house 30-259 (267) alignment 
Range on Protein: 760-1002
Range on HMM: 30-259/267.0
SDENKPFNRNQNIVPYDVNIIELEplprflDCQHTYVNASYIMVNKddeQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDlriKCSQYWPS
. .|. .|| .. .||| ... |       . .. |.||||.   |   .....|.||.||. |. ||. .. ..|   ||.|||  .|   .  ..|| 
aeknqernrlddnlpyddtrvilr......tkeeeyinasyvegyk...tknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPP

R--GSEDYGPFTVTLQKETTSNSFIIRELTLHVsgSAQSTLLITHYQFIDWLEYGP-QPPINSLvkFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMS
.   .. |  .||    |   | . |  | |..    .|.  .| | .  |      .| .. |  |  .  || |    |.||.|| | ||.|.|. . 
kmgqakkyqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrsGtflvid

CSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQA
  .. | ||.. ||   .  .|.||. ...|...|. .|| . | |
sqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 751-1001 6.7e-35 115.6 In-house 30-276 (307) alignment 
Range on Protein: 751-1001
Range on HMM: 30-276/307.0
PD-LPTDIASSDENKpfNRNQNIVPYDVNIIELeplpRFLDCQHTYVNASYIMVNKddeQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDL
|. ....  |.. .|  || |..   | . | .    .|      |. | |. .     . .|.|..||||. |. .|| |. |||  ...|| |. |  
pegvtveafsantdk..nryqdvkcqdkgrivv....kfdglasdyihanylgiai...kpkkficaqgplentqysfwamaiqekvesvimlckviela

RIKCSQYWPSRGSED--YG--PFTVTLQ----KETTSNSFIIRELTLHVSGsAQSTLLITHYQFIDWLEYGpQPPINsLVKFNKIisNQTEHKKGPIVVH
.||| ||||    .   .|  | |....    |. . .  .|   ||.|   || .  |.|.|. .| . |  |.|| |   | .  . .. .. |.|||
kikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrg.vpqin.ltainll..eavrydtnpvvvh

CSTGGGRTGAFIGMSCsIKDALT--ESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
||.| ||.|. ...|  ..| .   .   |.  .|  .|.||   |||  ||. .|  .|| 
csaGvGrsGtivaisl.vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1097-1321 1.5e-34 114.2 In-house 47-266 (270) alignment 
Range on Protein: 1097-1321
Range on HMM: 47-266/270.0
SPDYINAVFIPvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG----TIEFGEFTISVREEW
   |||| ...                ...| .| |..||  | ..||.||.... |.|||.....|   . |..|||.|     ..|.|. .. . .| 
ataYinAnyvr.............GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalsee

GHQSFSRKLLLVRnnKNNMLRRLAHFQVDGWSNDDITSCNE-----GAIINTMNLVKTLQRKS-PNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVD
 .. . .. | ..  ..   ||| ||.   | .. . . ..       ...... |.  ...   ..|.|.|||. .||. .. |   .|  ..... ||
keegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvd

VFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNL
| . ....| . .  ||   ||....   . |.. 
vlaiieelRkdRmalvqhpeqyeflykavveyaer
0049260 (Phosphotyrosine protein) phosphatases II 810-996 2.6e-34 113.5 In-house 8-144 (152) alignment 
Range on Protein: 810-996
Range on HMM: 8-144/152.0
GQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWpsrgsedygpftvtlqkettsnsfiireltlhvsgsaqstllitHYQFIDWL
....||||||.. |. |||||... .. .|||||.|.|. ..|| ||.                                            .|... | 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwp

EYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIkdalteSIIDIPAVVTIMREQRMMMIQTLDQYMLVHE
 .|... .  |  ....|    ..|.||..|||| | ||||... .   .        ...  .|  .||.|...... .|.....|
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0049772 (Phosphotyrosine protein) phosphatases II 751-1001 3e-34 114.5 In-house 34-279 (314) alignment 
Range on Protein: 751-1001
Range on HMM: 34-279/314.0
PDLPTDIASSDENKPFNRNQNIVPYDvNIIELePLPRFLDcqHTYVNASYIMVNkddeqgQKYIATQGPLDRTVVDF----------WRMV--WQEKACA
|.| . .|.  .|.  ||...|.|.| |   | |   . .  . | ||||.         .|.|||||||. |||||          ||||  .. .   
peltilvadlflnrdknryldilpad.nrvil.pglpvsg..sdyinasyvdgf......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrd

IVM---------------------LTKLQEDLrikcsQYWPSRGSEDYGpftvtlqKETTSNSFIireltlhvsgsaqsTLLITHYQFIDWLEyGPQPPI
|||                     |..| .        ... .  |..        .|......               . |. .|  |..   | .|..
ivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk.......eelydpelf..............erlgikylripvpD.gsapll

NSLVKFNKIISNQteHKKGPIVVHCSTGGGRTGAFIGMSCSIKDAlteSIiDIPAVVTIMREQRM-----MMIQTLDQYMLVHEAVLEQ
. . .| ..| .   .|.||..|||. | |||| |. . . .|      . ..  ..  .|..|.      .|..|.||  ..||.|| 
edfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 798-1000 3.9e-34 112.6 In-house 81-281 (290) alignment 
Range on Protein: 798-1000
Range on HMM: 81-281/290.0
ASYIMVNKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE--DYGPFTVTLQKETTSNSFI-IRELTLHVSGSA
  |.  |  .     .| |||.|  ||.|.|||| |||. ||||| .| || . ||.||.| .  |   .| .||.  .|.. .. |  . |..    | 
GdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsG

QSTLLiTHYQFIDWLEYGPQPPINSLVKFNKIIsnqtEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLV
..  |  |.. . | .        .|..  .|.     .  ||.|||||.| ||||.|. .  ...  |    .|.  .|  .|. |.  .|   ||...
kehkl.khlkikswpdksvalstlallrtlril....rkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylal

HEAVLE
 |..|.
veilld
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1087-1320 4.1e-34 113.0 In-house 54-277 (281) alignment 
Range on Protein: 1087-1320
Range on HMM: 54-277/281.0
DQWRVHL----KSESPDYINAVFIPvliinlyviflssqSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG-TIEF
|. ||..    .... ||||| |.|              .||..|..|..|.|. ..  .||.|........|||.   .|..   | .||| .  ....
DatrvkvtpneenkntDYinanfvp..............gykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselky

GEFTISVREEWGHQSFSRKLLLVrNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKS
|..|..  .|  .... .. . . .....  |......   | .  . . .  ....  . |. |..|. ..|...|||  .||. .. |    |.....
gdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPa.ttkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkavea

S-SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVN
. . .|| ..|...| .    ||   ||. ..     ...
eleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN6_pd Subfamily PTPN6 1087-1320 7.9e-34 112.0 In-house 67-298 (306) alignment 
Range on Protein: 1087-1320
Range on HMM: 67-298/306.0
DQWRVHLK---SESPDYINAVFIPVLIINLyviflssqsyknDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGT-IEFG
|. || ||       ||||| .|   . .             || .| .|  |..|  |||.|... . . |||.   .|  .| ||.|||.| .  |.|
Dhtrvilkepsvpgsdyinanyikkevkgs............dksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyG

EFTISVREEWGHQSF-SRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITScNEGAIINTMNLVKTLQRKSP---NTPVLMHCSNMIGRSAVFCAAMATVDQ
. ...  .|  ....  |.|.. ...|..  |.. ...   | . .. . . ||... .. |.. |...    . |...|||. |||   |    . ...
kisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpk.dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkl

MKSS---SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVN
....     .|. ..|| .|    | || . |||....  ..|..
iekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
0043147 (Phosphotyrosine protein) phosphatases II 793-996 2.9e-33 110.4 In-house 5-155 (172) alignment 
Range on Protein: 793-996
Range on HMM: 5-155/172.0
HTYVNASYIMVNKddeQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLqedlrikcsqywpsrgsedygpftvtlqkettsnsfiireltlhVSG
..|.||||. ..      ...|||||||..|. |||||.....  .||.||.|                                            .  
sdyinasyldlyy...ipdrfiatqgplrntladfwrmlkelgithivnltel............................................lyd

SAQSTLLITHYQFIDWLEYGPQpPINSLVKFNKIISN-QTEHKKGPIVVHCSTGGGRTGAFIGMSCSIkdaltE-SiiDIPAVVTIMREQRMMMIQTLDQ
  . . |. .|... |  .|.. ... | .| ..| . . . ..||..|||| | ||||... .   .     .    ..  .|  .||.|....|. .|
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl..sleeavalvrekRpgavqnpsq

YMLVHE
|.....
yrflyy
subfamily_PTPN13_pd Subfamily PTPN13 1086-1313 5.8e-33 109.3 In-house 49-263 (273) alignment 
Range on Protein: 1086-1313
Range on HMM: 49-263/273.0
ADQWRVHLKSESPdYINAVFIPVLIinlyviflssqsYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG--TIEFGE
 |. ||.|..|.. |||| .| | .             |.   .|..| || || .|||.|..... . |.|..   |...  | .|||..   ..   .
ydetrvklgdegg.yinaslikvpv............gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsn

-FTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITSCNEgAIINTMNLVKTLQRksPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSS
 ..... .   ...|. . | |.... .  |..||..   | . .. |  .  ... .  |..||.   ..|...|||  |||| .. .  . .. ..  
rlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaa.ellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierd

SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
  .|| ..|...|    | || | || ... 
kefdvkeivrklreqrqgvvqtkdqyifvyk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 767-1000 8.9e-33 108.3 In-house 52-285 (305) alignment 
Range on Protein: 767-1000
Range on HMM: 52-285/305.0
NRNQNIVPYDVNIIELEPlprflDCQHTYVNASYIMVNKDdeqGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSED--
|| ...   | | . ||.        | |. | |.    .    ...| || ||..|  ||| | .|.|  || || .|.|    ||..|..|.  .   
nrykdvgcldnnrvkleg.....pwpheyihanyvstptn...pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

--YGPFTVTLQKETTSN-------SFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPINSLVKfnkiISNQTEHKKGPIVVHCSTGGGRTGAFIGM
   .   .... |....       .  ..|  | . |. .... .||| .||| . |  .  .....    . ...   |||||||||.| ||||. . .
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlaile....llekarpskgpivvhcsagigrtgsvvml

SCSIKDALTESIID-IPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
   ... |.  ||.    ..  .||||   ||| .||..||. .|.
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 752-1001 1.6e-32 107.3 In-house 23-268 (281) alignment 
Range on Protein: 752-1001
Range on HMM: 23-268/281.0
DLPTDIA----SSDENKpFNRNQNIVPYDVNIIELEP-LPRflDCQHTYVNASYIMVNKddeQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQ
| |.|..       .||  ||  ||   |.  ..|.  .|        |. | ||         . || ||||   |  |||||.|||.. ||||| .. 
dppsdlctvfnqpvnnk.knrylnipcldisrvqlkvkmpn..knstdyihanyirspf...lkrgyiltqgpkketradfwrmiwqenttaivmlcqfl

EDLRIKCSQYWPSR--GSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSaqsTLLITHYQFIDWLEYgpQPPINSLVKFnKIISnQTEHKKGPIVVHCST
|  | ||..|.|       ..  ..|. .  |  .|..   | |   |    | ||||. . .| ..  | |  | | . ||.  .   .  | |.|||.
etnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyege...trlithwlwkewpdw..qvpessevml.kilr.kirarstppvihcsa

GGGRTGAFIGMSCSIKDALTE-SIIDIPAVVTIMRE-QRMMMIQTLDQYMLVHEAVLEQ
| ||.|... .  ...   .  .. ||  .|. .|   |   .|||.||||. . .|. 
gvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 758-1001 1.1e-31 104.6 In-house 50-288 (305) alignment 
Range on Protein: 758-1001
Range on HMM: 50-288/305.0
ASSDENKPFNRNQNIVPYDVNIIELEPLPrflDCqhTYVNASYIMVNKDDEqgQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYW
 |.| ..  || |..   | ... |.  .    .   |. | |. .    |  ...|..|||||.|. .|| || |.|   |||| |  |  ..||.|||
qsadiaitknryqdvpcqdqsavkldkps...ps..dyihanyvgcpmipe..krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqyw

PSRGSEDYGPFTVTLQKETTS-----NSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPqPPInSLVKFNkIISNqTEHKKGPIVVHCSTGGGRTGAF
|    |     .  . .. .          |.  .|... | . .. . | |. .| . |  ||   |  .. ..|      | |||||||.| ||||. 
paaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv.ppc.kltsle.llsa.irgskvpivvhcsagigrtgti

IGMSCSIK-DALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
. .   ..  |   .   .| .|  .|.|| . ||.  ||. .|  .|. 
vaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 798-992 1.5e-31 104.2 In-house 80-271 (301) alignment 
Range on Protein: 798-992
Range on HMM: 80-271/301.0
ASYIMVNkddEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE--DYGPFTVTLQKETT--SNSFIIRELTLHVSGS
| .|  .    . ...|||||||. |  ||| |. | .   ||||..  |.|  ||..| |.. ||  | | |....... .  ... . |.| .. |  
anwipts...GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

AQSTLLITHYQFIDWLEYGPqpPiNSLVKFNKIIsNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYM
  .|  .||||. .| ..|   | .| ..  ... .   . . |||||||.| ||. ||||  .  .. ...  |..   .  .||.|   .||  |  
kfatrtvthyqysewtdrgv..P.kshaelfdlm.elvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
0051429 (Phosphotyrosine protein) phosphatases II 1098-1321 7.2e-30 100.0 In-house 4-227 (272) alignment 
Range on Protein: 1098-1321
Range on HMM: 4-227/272.0
PDYINAVFIPVLiinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMiFDREITTIVMLSPIMEGEEEACAQYWP------------KEGTIEFGEFT
..|||| ... .            ..  .. .. .. ||. | .|||..  .  |.|||.| . .| . . | .|||             . ||..| ..
sgyiNardvggy...........grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalr

ISVREEWGHQSFSRKLLLVRNN-KNNMLRRLAHFQVDGWSNDDITScneGAIINTMNLVKTlqrkspNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSV
. . .|. .  .    ||...  .... |.. |..  .|  . . .    |... ..|. .      . |||.|||  ..|.....|.   . ..  . .
vtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq...eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsleti

VD--------VFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVNL
||        ....|. .|   |||||. .||....  ...... 
vddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 1124-1312 1.3e-29 98.5 In-house 14-163 (174) alignment 
Range on Protein: 1124-1312
Range on HMM: 14-163/174.0
KNDKGFIIAQSPLRetrrdFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKegtiefgeftisvreewghqsfsrklllvrnNKNNMLRRLAHFQVDGW
   ...|. | ||.     ||.|...  |||.||| . .| . . | .|||                                ... . |   ...  .|
yitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredlerlgiqylylpw

SNDDITSCNEgaIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKsSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIH
  .   . ..  ... ...|.. . ..|. ||| |||  .||.....||.    ... .|.||....|. .|   ||.||. .||. ..
pDhgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
0051082 (Phosphotyrosine protein) phosphatases II 794-999 3.2e-29 96.9 In-house 4-150 (151) alignment 
Range on Protein: 794-999
Range on HMM: 4-150/151.0
TYVNASYIMVNkddeqgqkYIATQGPLDrtvvDFWRMVWQEKACAIVMLTKLQEDLriKCSQYWPSRGsedygpftvtlqkettsnsfiireltlhvsgs
.| |.||.  .        .....|||.    ||........  .||.|....|    .| .|.|. |                                
dyinfsyvtgg........lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

aqstLLITHYQFIDWLEYGPQPPINSLVKFNKIISNqteHKKGPIVVHCSTGGGRTGAFIGMSCSIKDaltesiIDIPAVVTIMREQRMMMIQTLDQYML
    . ..|....|| ..| .  ......| ... .   .|.||..|||| | ||||..... . . .      ... ...  .|..|....|. .|...
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

VHEAVL
.. |.|
qlfall
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1125-1313 4e-29 96.5 In-house 43-233 (237) alignment 
Range on Protein: 1125-1313
Range on HMM: 43-233/237.0
NDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE-GTIEFGEFTISVREEWGHQSF-SRKLLLVRNNKNNMLRRLAHFQVDG
  | .| || ||  .  |||.|...   . ||||. ..||.|. | .|||.      .| .|.|.. .     .  | |||... . . .| .  .|   
tpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqfts

WSNDDITSCNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
| .  .       .    |...  .  |  .| ..|||  .||...|    | . | |   |||... |...  . |  .| | || .|| 
wpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 793-1002 1e-28 94.8 In-house 79-290 (310) alignment 
Range on Protein: 793-1002
Range on HMM: 79-290/310.0
HTYVNASYIMVNKddeQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG-SEDYGPFTVTLQKETtSNSFIIRELTLH--
. |. | |.  |      . .| .||||. |..|||||..||.| .|..| |  |. | ||  |||| | .| ||   ||   |. |. | | .|..   
edyihanyvktny...lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlses.seefeicnlavtfv

---VSGSAQST-LLITHYQFIDWLEYGPQ-PPINSLVKFNKIISNQTEHkkGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMM
   |    | . |     ..| | ..  .  | .      . .  |  |  || |||||.| .|... . .  .|. .     .|.  |.| .. .|.. 
pdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh..gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraic

IQTLDQYMLVHEAVLEQA
|||  ||....   .  |
iqtelqyliidrvriifa
subfamily_PTPN1_pd Subfamily PTPN1 1087-1309 1.6e-28 94.2 In-house 45-261 (290) alignment 
Range on Protein: 1087-1309
Range on HMM: 45-261/290.0
DQWRVHLKSESPDYINAVFIPVliinlyviflssqsYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG---TIEFG-
|  |..|.... ||||| .. .               . .. .|..| || .|   ||.|.....  ..|||  ..| |.  ||||||..    ....  
dhsrikleradndyinaslvel..............eeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellled

-EFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLQRKSPN-TPVLMHCSNMIGRSAVFCA---AMATVD
 .... . .|  .. . ..|| . | | .  | . ||    |..  . ..  .| .. .  |.     |..  |...|||  ||||  ||     .. ..
tklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpesp.aaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvlie

QMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYK
. .  | ||. ... ..|    | .| . | .
kkddlssvdikkvllelrkyrlGliqtadqlr
0044763 (Phosphotyrosine protein) phosphatases II 791-998 5.3e-28 93.3 In-house 16-167 (178) alignment 
Range on Protein: 791-998
Range on HMM: 16-167/178.0
CQHTYVNASYIMvnkddeqGQKYIATQGPldrtvVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSedygpftvtlqkettsnsfiireltlhv
.   | |||.|.       .  |.....|     .|.........  .||.||. .|  ..|| .|||.. .                            
ersdyinaseil.......pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............................

sgsaqstlliTHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDaltesIIDIPAVVTIMREQRMmMIQTLDQ
           .|..| .  .|... .  . .| ..| .  . |.||..|||| | ||.|... .   .|       .......  .||.|. .... .|
..........iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgq

YMLVHEAV
.  ..|  
lrqLyefe
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 765-925 6e-28 92.6 In-house 33-191 (297) alignment 
Range on Protein: 765-925
Range on HMM: 33-191/297.0
P--FNRNQNIVPYDVNIIELEPLPrfldCQHTYVNASYIMVnKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGS
    || ..|. .| . . |   .     .. |.|| |..   |.|.  ||| .||||..|| |||..|...   .|||..||||| | ||  ||||   
slrknryrdilatddtrvkllrvi....terdyinadyvvf.pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

ED--YGPFTVTLQKETT--SNSFIIRELTLHVSgsaQSTLLITHYQFIDWLEYGPQPPINSLVKFNK
|    | . |    .|.   .  |. ||.|      . .  ..| ||. | ..|    .. ||.|. 
erlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqa
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1127-1312 6.8e-28 92.1 In-house 94-276 (290) alignment 
Range on Protein: 1127-1312
Range on HMM: 94-276/290.0
KGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK-EG-TIEFGEFTISVREEWGH-QSFSRKLLLVRNNKNNMLRRLAHFQVDGW
  ||..| .|..|  |.|.|. . ....||||  ..|     |.||.|. || .. |||.|.   ||  . .   .|.| ||. ..    .| |...  |
amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkiksw

SNDDITSCNeGAIINTMNLVKTLqrkspNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIH
 .  ..  .  |.. |.  ....     . || .|||  |||.  | |  .... .     .|. ..|. .|    ..||   || .. 
pdksvalst.lallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 790-1001 1.1e-27 91.8 In-house 56-269 (285) alignment 
Range on Protein: 790-1001
Range on HMM: 56-269/285.0
DCQHTYVNASYIMVNKDDEqgQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSE--DYGPFTVTLQ--KETTSNSFIIRE
. .. |. ||.. .   |.    ||.|||||  |. |||.|..||| . ..||  | |    ||. |.| .  |   .| . .||   || .    |.  
nhdrdyihaswmrmpgkdq..styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilna

LTLHVSGSAQST-LLITHYQFIDWLEYGPQPPINSLVKFNKIISnQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMM
||.  .  | |  | . | |   | .         .... | .  . . |. ||.||||.| ||| .|.|.  .    . .  |..  .|  ||  |.  
ltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk.kvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqa

IQTLDQYMLVHEAVLEQ
.|.  |.....  ..| 
vqshmqflflyvvlmey
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 811-995 4.5e-27 89.5 In-house 5-197 (199) alignment 
Range on Protein: 811-995
Range on HMM: 5-197/199.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR--GSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSA-QSTLLITHYQFID
..||||| ||  |. |||.|||.  .  |||.   | .     . |||.   |.  || ..|| .  ||   . |  | |  . .|  ||  |.||||  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WLEYGpQPPINSLVKF---NKIISNQTEH-KKGPIVVHCSTGGGRTGAFIGMSCSIKD--ALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVH
| |    | .  .| |    . .|.. |  |  |..|||| | | || |. .   ..       |..|.  |   .|. |  .| .|..| ...
wkekt.tpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 811-995 4.9e-27 89.4 In-house 4-196 (198) alignment 
Range on Protein: 811-995
Range on HMM: 4-196/198.0
QKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR--GSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSA-QSTLLITHYQFID
..||||| ||  |. |||.|||.  .  |||.   | .     . |||.   |.  || ..|| .  ||   . |  | |  . .|  ||  |.||||  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WLEYGpQPPINSLVKF---NKIISNQTEH-KKGPIVVHCSTGGGRTGAFIGMSCSIKD--ALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVH
| |    | .  .| |    . .|.. |  |  |..|||| | | || |. .   ..       |..|.  |   .|. |  .| .|..| ...
wkekt.tpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_PTPN14_pd Subfamily PTPN14 1096-1320 9.5e-27 88.8 In-house 74-297 (300) alignment 
Range on Protein: 1096-1320
Range on HMM: 74-297/300.0
ESPDYINAVFIPVLIinlyviflSSqsykNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE----GTIEFGEFTISVREE
.| .||||  | | .        ..    ... .|.||.||. | .|||.|... ... ||||  . |.  | . .|.||.     |.|||.| .. .  
nstgyinassikvsv........gg....kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfs

WGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITSCNEGaIINTMNLVKTLQRK--------SPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSS
   .|.  . | ..    .  | . |.|   |..... .  .|  .. .. |. ..||        . . |||.|||. .||. |   .   .  ..   
edsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkg.flsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehne

VVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVN
..|. .... .|      ||. .|||.....   |..
eidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1125-1310 7.5e-26 85.6 In-house 88-272 (301) alignment 
Range on Protein: 1125-1310
Range on HMM: 88-272/301.0
NDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEFTISVREE---WGHQSFSRKLLLVRNNKNNMLRRLAHFQ
. . ||..|.||..|. ||| |.   .. .||||.  .| .|| |..| | .   ... | |.| ....     ..   |.| ..   ..   | . |.|
hphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyq

VDGWSNDDITSCNeGAIINTMNLVKtlqrKSpNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKM
   |.. ..       . . |.|||    || . |...|||. ||||  | ..     ....   ... ...|..| .   .||.. |   
ysewtdrgvPksh.aelfdlmelvk....ks.ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_ptpA1_pd Subfamily ptpA1 742-956 2.6e-25 84.0 In-house 24-250 (418) alignment 
Range on Protein: 742-956
Range on HMM: 24-250/418.0
REQFKRLGVPDLPTDIASSD--ENKPFNRNQNIVPYDVNIIELEPLPRflDCQHTYVNASYImvnkDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAI
.|.|. |     |.. .  |   |   ||  ||.| .   ..|. .         |.|| ||    |    ...|.|||||  |. |||||||....  |
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqd..kegsdyinanyi....dgaypkqfictqgplpntiadfwrmvwenrcrii

VMLTKLQEDLRIKCSQYWPSR-----------GSEDYGPFTVTLQKE--TTSNSFIIRELTLHVSGSAQStllITHYQFIDWLEYGPQ---PPINSLVK-
|||..  |. |||| .||| .           | | .| ..| | .         | |.. | . | ..    ||.||.  | ..       |.  |.. 
vmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrd...itqyqyegwpdhnipdhtqpfrqllhs

----FNKIISnqTEHKKGPIVVHCSTGGGRTGAFIGMS
     |.||   .  .. ||.||||.| ||||.|    
itnrqnqiip..ssdrnvpiivhcsagvgrtgtfctav
subfamily_PTPRN_pd Subfamily PTPRN 1127-1320 3.4e-25 83.4 In-house 100-293 (297) alignment 
Range on Protein: 1127-1320
Range on HMM: 100-293/297.0
KGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFGEFTISVREE--WGHQSFSRKLlLVRNNKNNMLRRLAHFQVDGWS
  .| .|.|| .|  |||.|.... .. ||.|... | . ..|..|||.||.  .. . . .  |  | .. . | .  ..| ...  | .. |    | 
payiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsf.ylknlqtsetrtvtqfhflswp

NDDITSCNEgAIINTMNLVKTLQRKsPNTPVLMHCSNMIGRSAVFCAAMATVDQM-KSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYVN
. .. .    ....    |    |    .|...|||.  ||. |...    .... |    .|.  |.. .| . || |. | |.... |  |  ||
eegvPasak.sllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevn
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1090-1319 2.3e-24 80.8 In-house 49-259 (267) alignment 
Range on Protein: 1090-1319
Range on HMM: 49-259/267.0
RVHLKSESPDYINAVFIpvliinlyviflssQSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEeeaCAQYWPKE--GTIEFGEFTIS
|| |. .  .|||| ..              ..||  . ||. | ||. |  ||...| |.....||.| .. ...     ..|| .   . .. ..|. 
rvilrtkeeeyinasyv..............egyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakkyqdltve

VREEWGHQSFSRkLLLVRNNKNNMLRRLAHFQVDGWsndDITSCNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDV
   |   . .   . |  . ||.  . .. .    |   .| . |.  .   . ..   | .  | |....||. .|||  |  . . ....|  .|.|.
hslekeendyqi.itlelkfknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdi

FQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
|. ....|   .| |. | .|  || | | | 
fdflrkirsqriglvdtkeryiyihellaeya
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 767-1002 3.7e-24 80.2 In-house 47-271 (288) alignment 
Range on Protein: 767-1002
Range on HMM: 47-271/288.0
NRNQNIVPYDVNIIELEplprflDCQHTYVNASYIMvnkDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSED--
.| .|.   |.  . |.      |  . |..|  .      .  .. | .| ||. |.  .|.|. ..    ||||..| |  . |  .|.||.  |   
dryenlprcditrvkls......ddpdfyiaanvvs...sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFIDWLEYGPQPPINSLVKFNKIIsnqtEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALT
.| .    .|. .    ...  .|..|   . . .. .  . .| . |      | ... ...    .  . |||||.|.| ||||..| .   .. .  
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrl

ESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQA
.  . |. ... .||.|.  |||  ||. ||  |||. 
ddflgirsllaklreerfkaiqtemqylyvhrcvleel
0041856 (Phosphotyrosine protein) phosphatases II 1122-1317 5.2e-24 80.2 In-house 29-169 (182) alignment 
Range on Protein: 1122-1317
Range on HMM: 29-169/182.0
SYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSpimegeeeaCAQYWPkegtiefgeftisvreewghqsfsrklllvrnnkNNMLRRLAHFQVD
..  .. ||..| || .|  ||..|. .. |||||.|.         . .|||                                  ..  |   ...  
gslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..................................ellerlgiqylyl

GWSNDDITScnEGAIINTMNLVKTlqrksPNTPVLMHCSNMIGRSAVFCAAMATVDQmkSSSVVDVFQTVKNMRvnlPGAVQNKGQYKMIHTLAAA
.|  .....     ... .. |.      .. ||| |||  .||.....||     .  . |. .....|...|   ||.|..  || ... ..  
pwpDhgvpd..ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl..gvsleeavklvrsrR...pgmvitpnqyfflqlalle
0046846 (Phosphotyrosine protein) phosphatases II 1129-1317 6.1e-24 80.2 In-house 25-171 (176) alignment 
Range on Protein: 1129-1317
Range on HMM: 25-171/176.0
FIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIEFgeftisvreewghqsfsrklllvrnnknnmlrrlaHFQVDGWSNDDI
.|. | ||..|  ||..|...  ||..|.|   .| .   |..||| . . ..                                   .... .|   ..
piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...................................qylhlpwpDhgv

TSCneGAIINTMNLVKTLQRKSpnTPVLMHCSNMIGRSAVFCAAMatvdQMKSSSVVDVFQTVKNMRVNLP-GAVQNKGQYKMIHTLAAA
 .    .... ...... ...    ||| |||  |||.....||      ....  ..|..... .|   | ||||. .||....  .  
pdl..elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 1124-1313 1.3e-23 79.1 In-house 17-155 (172) alignment 
Range on Protein: 1124-1313
Range on HMM: 17-155/172.0
KNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPImegeeeacaqywpkegtiefgeftisvreewghqsfsrklllvRNNKNNMLRRLAHFQVDGW
   . ||. | |||.|  |||.|. .. ||.||.| .                                             ... .  |   ...  .|
yipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpellerlgiqylylpw

SNDDITscNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVdqmKSSSVVDVFQTVKNMRvnlPGAVQNKGQYKMIHT
   . .  .   ..........|. .||. ||| |||  .||.....||       .. |. .....|...|   ||||||..||. .. 
pDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml...lglsleeavalvrekR...pgavqnpsqyrflyy
0049260 (Phosphotyrosine protein) phosphatases II 1125-1312 2.7e-23 77.7 In-house 7-143 (152) alignment 
Range on Protein: 1125-1312
Range on HMM: 7-143/152.0
NDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWpkegtiefgeftisvreewghqsfsrklllvrnnknnmlrrlahfQVDGWS
. . ||..| |...|  |||.|. .  |||||||   .|  .. |.||.                                             |.  . 
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlp

NDDITSCNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVdqmKSSSVVDVFQTVKNMRvnlPGAVQNKGQYKMIH
 .| . ..   ..  ..|.    ..... ||| |||  .||.....||       .  |. .... |...|   ||||.|.||.. ..
wpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml...lgvsleeavalvrekR...pgavpnpgqlrfly
PTPc_DSPc_SM00012 900-1000 4.1e-23 77.0 In-house 2-105 (105) alignment 
Range on Protein: 900-1000
Range on HMM: 2-105/105.0
ITHYQFIDWLEYG-PQPPiNSLVKFNKIISNQTEHKK--GPIVVHCSTGGGRTGAFIGMSCSIKDALTE-SIIDIPAVVTIMREQRMMMIQTLDQYMLVH
..||.. .| . | |... .|.... . . .......  .|.|||||.| |||| |. ... ...  .| . .||  .|  .|.||. |.||..||. ..
vkhyhytgwpdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

EAVLE
.|.||
ralle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1121-1318 6.7e-23 75.9 In-house 74-276 (287) alignment 
Range on Protein: 1121-1318
Range on HMM: 74-276/287.0
QSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK-EGTIEFGEFTISVREE-WGHQSFSRKLLLVRNNKNNMLRRLAHF
 ||..|. || ||.|.  | ||||....... .......  .|     | .|||. |  .  | ... . .    .  .. . | . . . .  | .  .
asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkql

QVDGWSNDDITSCNEGAIINTMNL--VKTLQRK-SPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLA
..  | .. ..    | |  ...      |.|. |   |...|..  |||| .. | .. |.....   ||| ..|  .|    . ||   |....    
dllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal

AAY
..|
vty
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1125-1318 6.8e-23 76.1 In-house 80-276 (307) alignment 
Range on Protein: 1125-1318
Range on HMM: 80-276/307.0
NDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG--TIEFGE--FTISVREeWGHQSFS--RKLLLVRNNK---NNMLRRL
. | || || || .|. .|| |. . .. ...||  ..|  .  | |||| |   .  |||   |||| .  | . ..   .|. | . |    .  | .
kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvan.lgakklapdedlinvttlkvdwaqksrti

AHFQVDGWSNDDITSCNEGAIintmNLVKTLQRKspNTPVLMHCSNMIGRSAVFCAAMATVDQM-KSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
 |.| . | .  .   | .||    ||... . .  . ||..|||  .|||    |     |.| .     |. . |...| . . |.|.. ||  .| .
qhlqwenwpdrgvpqinltai....nlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrv

AAAY
   |
lley
subfamily_egg_pd Subfamily egg 753-999 7.5e-23 75.6 In-house 30-267 (307) alignment 
Range on Protein: 753-999
Range on HMM: 30-267/307.0
LPTDIASSDENKPFNRNQNIVPYDVNIIELEpLP--RFLDcqhTYVNASYImvnKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDlr
 .   | ||.|.   |.. .   |.  ..|| |.  ..||    .. | ..   | .    ..| .| ||  || ||||||.||.   |||||  .|   
islttaasdnnlekarskrvhckdssrvkle.lrrGqyld...dfihanrv...kGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..

IKCSQYWPSRGSEDY----GPFTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHYQFiDWLEYGP-QPPINSLvkfnkiisNQTEHKKGPIVVHCSTG
 .|  |||   |.      | . ..  |       . |   |.. |. .  . . |.|  |. . .    |.. |         .  .   |.||..  |
erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvl........rklrnlskpvvvqdilG

GGRTGAFIGMSCSIKDALTESIIDIP--AVVTIMREQRMMMIQTLDQYMLVHEAVL
  ...... .  .. . |   |   .    |  .| .| . ...  .|..|.  ||
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1121-1313 1.3e-22 74.8 In-house 85-273 (439) alignment 
Range on Protein: 1121-1313
Range on HMM: 85-273/439.0
QSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEeacaqYWPKEGTIEFGEFTISVREEWGHQSFSRKLLLVRNNK--NNMLRRLAHF
. | .|| .| .| | .||  |||......  .|||||. ..|        ||| .. . .|. .. |  .     .  . . | |..  ..  | . .|
kGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqf

QVDGWSNDDITScNEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
.   | . .. . .   ... .  ... . |    ||..|||  .||.    |   ...|.|.   ||.   || .| .    ||.  || .|. 
hyiawpdknvpa.qashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiyn
subfamily_CG42327_pd Subfamily CG42327 752-912 1.5e-22 74.6 In-house 13-175 (319) alignment 
Range on Protein: 752-912
Range on HMM: 13-175/319.0
DLPTDIASSDENKPFNRNQNIVPYDVNIIELEPL-PRFL-DCQHTYVNASYIMVNKDdeQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDL
|||  ||..||  .  .... |   | . | ..  .|   | .  |..|||.   .|      |||.| .|. .  ||||.||. ..  || ||.|.|  
dlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydd..apnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselG

RIKCSQYWPSR----GSEDYGPFTVTLQKETTSNSFIIRELTLHVSGSAQSTlLITHYQFiDWLEYG
  .|..|.|..    . . || . |||..  . . ..|  | |.     .|   .||| . .||| .
ikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesr.elthywy.kwleae
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1123-1316 2.7e-22 74.1 In-house 71-267 (285) alignment 
Range on Protein: 1123-1316
Range on HMM: 71-267/285.0
YKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEFTISVRE---EWGHQSFsRKLLLVRNNKNNMLR--RL
 |..  .| .| || ||  |||.||.. .|. ..||  ..||  | || |.|..    ..||.. |.. |   |    .   . | | | ..       .
gkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagti.lnaltvintedasseplym

AHFQVDGWsNDDITSCNEGAIINTMNLVKTLQRKspNTPVLMHCSNMIGRSAVFCA-AMATVDQMKSSsVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
 | ||  |  |...  .   .|.  . || .. |  ..|. .|||  .||.| |     ||.  |.    ..... |..||     |||.. |. ... .
nhvqvpww.pdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenp.niemldivremramrfqavqshmqflflyvv

AA
  
lm
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1125-1313 9.3e-22 72.0 In-house 79-263 (281) alignment 
Range on Protein: 1125-1313
Range on HMM: 79-263/281.0
NDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG--TIEFGEFTISVREEWGHQSFSRKLLLVRnnKNNMLRRLAHFQVDG
  .|.|..| | .||| |||.||.. . |.||||  ..| . | ||.|.|..    ..| ....|  .    .|.    | .    .   | ..|.    
lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls..yegetrlithwlwke

WSNDDITSCNEgaiInTMNLVKTLQRKSpnTPVLMHCSNMIGRSAVFCAAMATVDQMKSS-SVVDVFQTVKNMRVNLP-GAVQNKGQYKMIHT
| . ..    |   .  ..... .. .|  || ..|||  .|||  . |   ... ..|  .. |. | |  .||     .||   || .|  
wpdwqvpesse...v.mlkilrkirars..tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 765-891 4.4e-21 70.0 In-house 49-180 (350) alignment 
Range on Protein: 765-891
Range on HMM: 49-180/350.0
PFNRNQNIVPYDVNIIELEPLPRFLDC-Q-----HTYVNASYIMVN---KDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQ
  || .||.||. . ..|.  ..  |. .       |.||.|. ..   .. . . ||||||.|| .|| ||.... . |   |..||...|  . || .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPSRGSEDygpFTVTLQKeTTSNSFIIRELTLHVS
||.  . .|   .|| |.  .  |   |.. .|...
YWqegsydd...itvklas.kwenimgindsslysa
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1125-1313 7e-21 69.5 In-house 49-234 (239) alignment 
Range on Protein: 1125-1313
Range on HMM: 49-234/239.0
NDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKeGTIEFGEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWS
. | .| .|  .  .  |||.|...     ||||. ..|| .. | ||||   | .. .. ...|.      .  . ... .  .   | . ....  | 
spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwp

NDDITSCNEgAIINtMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
.  .      |..  .    | .      | ..|||  .||.  |    | . | |    ||.|. || .| . |  ||   || .|| 
dkgvpqyat.avlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1125-1313 7.2e-21 69.4 In-house 50-235 (239) alignment 
Range on Protein: 1125-1313
Range on HMM: 50-235/239.0
NDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKeGTIEFGEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWS
. | .| .|  .  .  |||.|...     ||||. ..|| .. | ||||   | .. .. ...|.      .  . ... .  .   | . ....  | 
spkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.stskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwp

NDDITSCNEgAIINtMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
.  .      |..  .    | .      | ..|||  .||.  |    | . | |    ||.|. || .| . |  ||   || .|| 
dkgvpqyat.avlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 891-1020 1.9e-20 67.6 In-house 84-212 (440) alignment 
Range on Protein: 891-1020
Range on HMM: 84-212/440.0
SGSAQSTLLITHYQfiDWLEYGPQPPINSLVKFN-KIISNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLD
.|    ||   |||   | . |       ..|.   .  .| .  .||..||||.| ||||  | . . ...|     ||| ...  ||..|  |.|| .
ngiesrtlkqyhyq..gwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYMLVHEAVLEQALCGDTQIAACDLQSTISS
|| .|||||||  ||||| |   |.   .  
qyafvheavlegllcgdtliledditerveq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1087-1317 3.1e-20 67.2 In-house 46-293 (297) alignment 
Range on Protein: 1087-1317
Range on HMM: 46-293/297.0
DQWRVHLKSESP--DYINAVfipvliinlYVIFLSSqsyKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK--EGTIEFG
|. ||.|.   .  |||||          ||.|      ..|  .|.|| ||..|  |||........ .|||.. . |.  . || |||.  ..  . |
ddtrvkllrviterdyinad.........yvvfpde...eadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkag

EFTIS----VREEWGHQSFSRKLLLVRnnknNMLRRLAHFQVDGWSNDDITS--------------CN-----EGAIIN-----TMNLVKTLQRKSP-NT
.. .     . .|. .  ..   |. |    .  | . | |  .| .  . |              |        |...      .  ...|. . | |.
dvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprna

PVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAA
..|.|||  .||| |   ... .....   . ||   .. .| . .  ||   |........ .
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
PTPc_DSPc_SM00012 1216-1315 4.6e-20 67.1 In-house 3-103 (105) alignment 
Range on Protein: 1216-1315
Range on HMM: 3-103/105.0
AHFQVDGWSNDDITSCNeGAIINTMNLVKTLQRKSP-NTPVLMHCSNMIGRSAVFCAAMATVDQMKSS-SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
 |... ||..  . .    .|..... ||. ..||  ..||. |||. .||...|.|.   ..|.... . ||.||.|| .|   ||.||.. || ....
khyhytgwpdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

LA
  
al
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1086-1318 5.8e-20 66.5 In-house 55-270 (288) alignment 
Range on Protein: 1086-1318
Range on HMM: 55-270/288.0
ADQWRVHLKSESPDYINAVFIPvliinlyviflssqSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGE
 |  ||.|. ..  ||.|  ..              | |... .| ||.||. |   .|||... ..  ||||. ..|   |. |.|.| .   .. .| 
cditrvklsddpdfyiaanvvs..............sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigr

FTISVREEWGHQSFSRKLLLVRNNKNNMLRR-LAHFQVDGWSNDDITScnegAIINTMNLVKTLqrKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSS
.   |...        |. |.|..|.   .  . .  .  | .| .        .  ..|.. |  || . |...|.|. .||.. .   .  .......
lctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPe....nylsplrllevl..kslqkPivvhssaGvGrtgtlililialeslrld

SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
  . . . ....| .   |.| . ||  .| .   .
dflgirsllaklreerfkaiqtemqylyvhrcvlee
0051082 (Phosphotyrosine protein) phosphatases II 1127-1312 1.3e-19 65.7 In-house 13-146 (151) alignment 
Range on Protein: 1127-1312
Range on HMM: 13-146/151.0
KGFIIAQSPLRetrrDFWKMIFDREITTIVMLSPIMEGEeeACAQYWPKEGtiefgeftisvreewghqsfsrklllvrnnknnmlRRLAHFQVDGWSND
 |... . ||     ||.... .  |.|||.| . .| .   |..|.|..|                                   ... |.....|.. 
gglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................ievlhipildwpdp

DITSCnegaiINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVdQMksssvVDVFQTVKNMRVNLPGAVQNKGQYKMIH
..  .     ..... .  | .. .| |||.|||  .||.....|..    ..     |....... .|   ||.|| . |. ...
glpls.....fdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqflfql
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 785-974 1.9e-19 64.8 In-house 11-167 (255) alignment 
Range on Protein: 785-974
Range on HMM: 11-167/255.0
LPRFLDCQHtyVNASYIMVNKDDEQGQKYIAtqgpldrTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSNSFIIR
||| |. .   | .  .  .|| .. . |.        ||  |.... | |.  .|||. ..|. . |||.|.|    |      |..    .|.  ..|
lPrilided..vctehvkPekdkkrknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlr

ELTLHVSGS-AQSTLLITHYQFIDWLEY-GPQPPINSLvKFNKIISNQtehKkgPIVVHCSTGGGRTGAFIgmscsikdaltesiidipavV
 |..    .  . |  ..||..  |.|  .|. . . | .  |.. .    |  ..|||||||.||. ||.                    .
tleitstlgekkkthtvkhysykGWieknaPelareil.nilkvvrds...k..svvvhCstGiGrsaafv....................l
0048076 (Phosphotyrosine protein) phosphatases II 856-999 2.9e-19 64.6 In-house 2-140 (145) alignment 
Range on Protein: 856-999
Range on HMM: 2-140/145.0
YWPSRGSED--YGPFTVTLQKETTSNSFIIRELTLHVSGSAQStLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKkGPIVVHCSTGGGRTGAFI
||||.  ..  .|.....|. |.  .  | . |.|    .  .  |...|....|  .|... .. | .| ..| .  ... ||..|||| | ||||...
ywpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv

GMSCSIKdaltESiIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVL
.. . ..    .. .... ..  .|.||...... .|.  ..|..|
aaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 794-999 3.2e-19 64.2 In-house 47-256 (290) alignment 
Range on Protein: 794-999
Range on HMM: 47-256/290.0
TYVNASYIMVNkddeQGQKYIATQGPLDRT-------VVDFWRMVWQEKACAIVMLTKLQEDLRI----KCSQYWPSRGSE--DYGPFTVTLQKETTSNS
 |. |... .     .|.. |.|| |. ..       . .|| |. |||.  .||| . .|  .      |..| | .  |   .. .||  ..  . . 
dyiHAnrvtcp....nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

FIIRELTLHVSGSAQSTllITHYQFIDWLEYGPQPPINSLVKFNKIISnqteHKKGPIVVHCSTGGGRTGAFIGMSCSIKDAL-TESIIDIPAVVTIMRE
...|||...  .  . |  .||... .| .   |.   .|..  . .      .| |..|||  |  |  |.  .  .      |.. . . .|.  .|.
vetRelvvkfddeeeft..vtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

QRMMMIQTLDQYMLVHEAVL
|| ..|..  ..  |  ...
qralaitsalelafvdagiv
0044763 (Phosphotyrosine protein) phosphatases II 1127-1315 9.1e-19 63.2 In-house 28-167 (178) alignment 
Range on Protein: 1127-1315
Range on HMM: 28-167/178.0
KGFIIAQSPLretrRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTiefgeftisvreewghqsfsrklllvrnnknnmlrrlahFQVDGWSND
 |..... |      |..... .  ||.||.|.. .|.  . | .|||.|                                         .|.  .  .
pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipip

DITSCN-EGAIINTMNLVKTLQRkSPNTPVLMHCSNMIGRSAVFCAAMATVDQmkSSSVVDVFQTVKNMRvnlPgAVQNKGQYKMIHTLA
| . ..    . ..........  ... ||| |||  .|||....||     .  . |. .... |...|   | .|.| ||.. .. ..
Dhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl..glsleeaielvrerR...p.ivpnpgqlrqLyefe
0048179 (Phosphotyrosine protein) phosphatases II 898-996 1.4e-17 59.2 In-house 47-139 (144) alignment 
Range on Protein: 898-996
Range on HMM: 47-139/144.0
LLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEhKKGPIVVHCSTGGGRTGAFIGMSCSIkdalTESiIDIPAVVTIMREQRMMMIQTLDQYMLVHE
  ...|....|  .|. . .. | .| ..| .  | ..||..|||| | ||||... .   .    ..  ...  ..  .|..|...... .|.. ..|
regiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1124-1312 2.9e-17 57.5 In-house 2-197 (199) alignment 
Range on Protein: 1124-1312
Range on HMM: 2-197/199.0
KNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK--EGTIEFGEFTISVREEWGHQSFSRKLLLVRNNKN--NMLRRLAHFQ
| .. .| .| |||||  |||.|...     |||.       |   . |||    || ..| ......    .  ..   |.. ||       | ..|.|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

VDGWSNDDITS--CNEGAIINTMNLVKTLQRkSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKS--SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIH
   | .          | .. . .. |  ..   ..||..|||.  | . || |    |   .   .||||.|.  | .|    | .    .|..|.
ftswkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1126-1312 3.9e-17 57.1 In-house 3-196 (198) alignment 
Range on Protein: 1126-1312
Range on HMM: 3-196/198.0
DKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK--EGTIEFGEFTISVREEWGHQSFSRKLLLVRNNKN--NMLRRLAHFQVD
.. .| .| |||||  |||.|...     |||.       |   . |||    || ..| ......    .  ..   |.. ||       | ..|.|  
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

GWSNDDITS--CNEGAIINTMNLVKTLQRkSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKS--SSVVDVFQTVKNMRVNLPGAVQNKGQYKMIH
 | .          | .. . .. |  ..   ..||..|||.  | . || |    |   .   .||||.|.  | .|    | .    .|..|.
swkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_eak_pd Subfamily eak 767-927 6.3e-17 55.9 In-house 54-207 (332) alignment 
Range on Protein: 767-927
Range on HMM: 54-207/332.0
NRN-QNIVPYDVNIIELEPLPRfldCQHTYVNASyimVNKDDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG--SE
|||  .||||| . ..| .  .    .  |.|||   . .  | |.||| |  . .  |  ||.|| ..|. |||.| .  |    |  .|.| ..    
nrnvvkivpydrylvrltssql...nrlGyinas...laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

DYGPFTVTLQKETTSNSFIIRELTLHVSgsaQSTLLITHYQFIDWLEYGpQPPINSLVKFNKII
..| . |. ..    | .  | | |..      |  . ||..  | |.   | .. .. . |..
kfGildverkefvkrniletrllelskG...nethrvlhykvfGwtett.lpkyedflalrkvm
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1122-1309 9.9e-17 56.0 In-house 55-249 (290) alignment 
Range on Protein: 1122-1309
Range on HMM: 55-249/290.0
SYKNDKGFIIAQSPLRET-------RRDFWKMIFDREITTIVMLSPIMEGEEE----ACAQYWPKE--GTIEFGEFTISVREEWGHQSFSRKLLLVRNNK
.. |.  .|. |||. ..         .|| |. . ... .|||   .| ...    |||.| |..  . . |. .|..  .   .. . .. |.|. ..
tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd

NNMLrRLAHFQVDGWSNDDITSCNegaiINTMNLVKTLQrkSPNTPVLMHCSNMIGRSAVFCAAMATVDQMK-SSSVVDVFQTVKNMRVNLPGAVQNKGQ
.. .  . | .. ||..  .   .    .  ..|.....    .|||..|| . | |||.. |       .  .|. | . . .|..| .   |.... .
eeef.tvtHsllkgWnklnvqedt....ktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsale

YK
. 
la
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1127-1319 1.5e-16 54.7 In-house 90-285 (302) alignment 
Range on Protein: 1127-1319
Range on HMM: 90-285/302.0
KGFIIAQSPLRETR---RDFWKMIFDREITTIVMLspIMEGEE-EACAQYWP--KEGTIEFGEFTISVRE--EWGHQSFSRKL-LLVRNNKNNMLRRLAH
.  |.|| | ...     .||.|.|...|...|.|  ..| |  ..  ...|   .   |.|.. . .|   .   . .   . .|  .  | .|  . .
rsiilaQlpkvdsedsveeFWrmvfqekivsvvil..vgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyv

FqvDGWSNDDITsCNEGAIINTMNLVkTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAA
.  . | .. .   . ...|.|.  |   .  . . ....   | .|| ..| .....|....... . . ..||..| . | ||..  || ...  .. 
l..tnWkqkkvp.vkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll

YV
|.
yi
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 761-998 2.7e-16 53.9 In-house 49-281 (302) alignment 
Range on Protein: 761-998
Range on HMM: 49-281/302.0
DENKPFNRNQNIVPYDVNIIELEplprflDCQHTYVNASYIMVNKDDeqgQKYIATQGPLDRTV---VDFWRMVWQEKACAIVMLTKlQEDLRIKCSQYW
 .|  .|.....  .| |.. ||       ..  ||||| . | .     .. | .| |   ..    .|||||.|||   .|.| . .|.|    |...
kknlkknqsedvpildsnlvkle......aepdsyvnaskvevPelt...rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvg.eeelkktlself

P--SRGSEDYGPFTVTLQKETTSNSFIiRELTLHVS--GSAQStLLITHYQFIDWLEYGPQPPINSLVKFNKIISNQTEHKKGPIVVHCSTGGGRTGAFI
|  |   ..|| . |  .|   ..     .... |   | ..| .|.. | .  | .      ...|.|  . . ..... . ..|.    | || |||.
pkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsns.vlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafl

GMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAV
 .  ...   ...   |  .|. .|.||  ....|.||. .. |.
tlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_egg_pd Subfamily egg 1128-1319 3.3e-16 53.8 In-house 84-270 (307) alignment 
Range on Protein: 1128-1319
Range on HMM: 84-270/307.0
GFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGeeEACAQYWPKEG--TIEF--GEFTISVREEWG--HQSFS-RKLLLVRNNknNMLRRLAHFQV
 ||.||.||..|  |||.|.|  |.  ||||.   |   | |  ||||    .. .  | . |   .        |   || ||  .  .  | | |.| 
efilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqg

DgwsndDItscNEGAIINTMNLVKTLQRKSpnTPVLMHCSNMIGRSAVFCAAMATV-DQMKSSS-VVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAY
|          | . .   ..... |.. |  .||.... . . ..|.. |.  .. . ..       | ..|. .| . . .|.   .| ... | . .
d.....vn...nssdvysplrvlrklrnls..kpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff

V
.
f
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 793-1001 3.7e-16 53.7 In-house 67-275 (312) alignment 
Range on Protein: 793-1001
Range on HMM: 67-275/312.0
HTYVNASYIMVNKDDEqgqKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSR----GSEDYGPFTVT---LQKETTSNSF-IIR
  |. | .. .    |   ....|||||. |.. ||...    ...|..|. . ||   ||..|          ||.  .|     ..    |.     |
nfyihanfvkictkpe...rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithr

ELTLHVSGSAQSTLLiTHYQFIDWLEYGPQppiNSLVKFNKIISNQTEHKKgPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMM
 | . |  . | . |  |||.  | ..|     .|     ...|     || |.. |||.| ||||... .   |         ..  .  ..| .|   
vlkvvvkatgqeskl.nhyqwaswpdhgmp...dscdtalrllsavkkdkk.pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrars

IQTLDQYMLVHEAVLEQ
.... ||. .  .||| 
vrvfpqyvyalrcvlef
subfamily_hpo-7_pd Subfamily hpo-7 780-954 4.3e-16 53.6 In-house 9-173 (263) alignment 
Range on Protein: 780-954
Range on HMM: 9-173/263.0
IELEPLPRFLDCQHtyVNASYIMVNKDDEQGQKYIAtqgpLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRGSEDYGPFTVTLQKETTSN
.. . ||| |. .   | .  .  .|| .. . |.     | .|.  |.... | |.  .|||.  .|. . |||.|.|    |      |..    . .
lkfgklPrilided..vctehfkPekdkkrknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs

SFIIR--ELTLHVSGsAQSTLLITHYQFIDWLEY-GPQPPINSLvkfnKIISNQTEHKkgPIVVHCSTGGGRTGAFIG
  ...  ||.  ..   . |  ..||..  |.|  .|. ....|    .|.   .. |  ..|||||||.||. ||  
dvllktlellstlge.KkkthtvkhysykgWiekndpelareil....nilkvarnsk..slvvhcstGiGrsaafsv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1125-1318 6.3e-16 52.9 In-house 94-288 (305) alignment 
Range on Protein: 1125-1318
Range on HMM: 94-288/305.0
NDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE-GTIEFGEFTISVREEWGHQSFSRKLLLVRN-----NKNNMLRRLAHF
 .| || || || .|  .|| |. .. .  ||||   .|     ||||||   |        | | .  | . . |   .           .    . |.
pekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhl

QVDGWSNDDITSCNegaiINTMNLVKTLqrKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSS-SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAA
|   | .  .  |.    . ...|. ..  .  . |...|||  |||.    |    ....    ..  . . || .| .   ..||  || .|| .   
qwtewpdrgvppck....ltslellsai..rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

Y
|
y
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1124-1319 1.7e-14 48.2 In-house 85-287 (305) alignment 
Range on Protein: 1124-1319
Range on HMM: 85-287/305.0
KNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGE--FTISVREEWG-HQSFSR-------KLLLVRNNKNNM
 | | || .|.|| .|  ||| | ..  . .| ||  ..|   . |..|.. .   ..|| |    |||. |     .| .       .  || .   . 
tnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgek

LRRLAHFQVDGWSNDDITSCnEGAIINTmnLVKTlqrKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDV-FQTVKNMRVNLPGAVQNKGQYKM
 |. .|.    | .  . .  . ||..   | |.   ..   |. .|||  |||.         .||. .  ...   . .. .| .   ..|   || .
arkvthyhwidwpdrgvpaa.dlailel..leka...rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylf

IHTLAAAYV
.| .   |.
vhqvilnyf
subfamily_CG42327_pd Subfamily CG42327 927-998 2.4e-14 47.7 In-house 237-311 (319) alignment 
Range on Protein: 927-998
Range on HMM: 237-311/319.0
ISN--QTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTE-SIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAV
||.   |....||.||||| | ||||  |    .|.   .    .||| .|  .|..|   ..| .|| ...  .
issrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 812-888 5.5e-14 46.3 In-house 237-311 (440) alignment 
Range on Protein: 812-888
Range on HMM: 237-311/440.0
KYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDlriKCSQYWPSR-GSEDYGPFTVTLQKETTSNSFIIRELTL
 .|||| ||| ||.||||.| . .  .|.|| .|..     || |||    |  .|||||  .     |   .| | |
afiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel
0049772 (Phosphotyrosine protein) phosphatases II 1096-1319 5.8e-14 48.0 In-house 70-280 (314) alignment 
Range on Protein: 1096-1319
Range on HMM: 70-280/314.0
ESPDYINAVFIPVLiinlyviflssqsykndKGFIIAQSPLRETRRDF----------WKMIF--DREITTIVM---------------------LSPIM
.. ||||| ..                    . ||..| || .|  ||          |.|..  |. . .|||                     | ...
sgsdyinasyvdgf.................lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllild

EGEeeacaqywpkegtieF----------GeftisvreewghqsfsrkllLVRNNKNNMLRRLAHFQVDGWSNdDITScNEGAIINTMNLVKTLqrkSPN
..                                                 . ....   |.  ..    ..  . .   .  .   .......   ...
gng...............neptaadlellk....................eelydpelferlgikylripvpD.gsap.lledfdeflefieea...dkg

TPVLMHCSNMIGRSAVFCAAMATVDQMKSsSVVDVFQTVKNMRVNLP--GAVQNKGQYKMIHTLAAAYV
.|||.||.  .||...|..|.  . ...  |. .... |...|   |  |....  || .|.     |.
gpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 932-1001 1.9e-13 45.0 In-house 224-294 (297) alignment 
Range on Protein: 932-1001
Range on HMM: 224-294/297.0
EH-KKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
|. .. ...||||.| ||.|  .     ..    . | |. |...|.|||| ...|||.|. |...|||..
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_CG42327_pd Subfamily CG42327 1127-1239 2.7e-13 44.3 In-house 72-186 (319) alignment 
Range on Protein: 1127-1239
Range on HMM: 72-186/319.0
KGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE----GTIEFGEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVdG
  .| || .| ..  |||......   .|| |. . |   . ||.|.| .    .|  .|.. .....   .. .    ||... .... | |.|.    
nsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.k

WSNDDITScNEGAIINT
| . .. . .| |.|  
wleaevPa.eeaaliam
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 939-1001 3.9e-13 43.5 In-house 1-63 (69) alignment 
Range on Protein: 939-1001
Range on HMM: 1-63/69.0
VVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
|||||.| ||||.|| .   .    .| ..||   |  ||  | ||.   ..||..|.|. | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1090-1192 5.1e-13 43.5 In-house 63-166 (350) alignment 
Range on Protein: 1090-1192
Range on HMM: 63-166/350.0
RVHLK--SESPDYINAVFIPVLIINLYVIFLSSQSYKNDKGF--IIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGtieFGEFT
||.||   .|.| ..    .   ||   . |.  | . . .|  | .|.||..|  ||.|.|.  ... |..|.. .| . | | .||.. .   . ..|
rvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs...yddit

ISVREEW
. . . |
vklaskw
subfamily_ptpA1_pd Subfamily ptpA1 1126-1277 6.7e-13 43.1 In-house 88-254 (418) alignment 
Range on Protein: 1126-1277
Range on HMM: 88-254/418.0
DKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIE-----------FGEFTISVREewGHQSFSRKLlLVRN---NKNNM
 | || .| || .|  |||.|...     |||||   |     | .|||..   |           || ... . |    |   |.. . ||     .  
pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelve..viqdperei.itrnirltfege

LRRLAHFQVDGWSNDDITSCNEG------AIINTMNlvKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVD
 | ....| .|| . .|    .       .| |  |  . .     | |...|||  .||.  ||.|.  . 
trditqyqyegwpdhnipdhtqpfrqllhsitnrqn..qiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 938-1001 6.8e-13 42.8 In-house 1-64 (69) alignment 
Range on Protein: 938-1001
Range on HMM: 1-64/69.0
IVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYMLVHEAVLEQ
.|||||.| ||||.|| .   .    .| ..||   |  ||  | ||.    .|...|.|. | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1139-1283 9.3e-13 42.8 In-house 40-183 (255) alignment 
Range on Protein: 1139-1283
Range on HMM: 40-183/255.0
TRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEFTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSNDDITSCNEgAI
|   |...|   . ...|||.   | . | | .|.| |  .   . . .... .   .  .    ..    .    . . |..  || .       .  |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar.ei

INTMNLVktlqRKSpnTPVLMHCSNMIGRSAVFCAAMATVDQ----MKSSS
 | . .|    |.|   .|..|||. ||||| |  |     .    .. ..
lnilkvv....rds..ksvvvhCstGiGrsaafvlaelvyqkmirsldtte
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1214-1319 1.2e-12 42.0 In-house 279-385 (392) alignment 
Range on Protein: 1214-1319
Range on HMM: 279-385/392.0
RLAHFQVDGWSNDDITsCNEG--AIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMI
 .. .|  ||        . |  ...  .  ||.   .  .  .|.||    ||. |||.||  . |.     ||.||||| .| .    || . .| ..
tvtqyqfhgwpkhgsd.qqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafv

HTLAAAYV
. .   |.
ydvireyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1213-1313 1.4e-12 41.7 In-house 89-188 (440) alignment 
Range on Protein: 1213-1313
Range on HMM: 89-188/440.0
RRLAHFQVDGWSNDDITSCnEGAIINTMNLVKTLQRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIH
| | ... .|| .  .     | ... .. |.  | |. | |.|.|||   ||..|  |  . . . | |  .|.|  ...|| | |  ||   || ..|
rtlkqyhyqgwpdkgvpkf.agpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

T
 
e
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1133-1309 1.9e-12 41.2 In-house 97-278 (302) alignment 
Range on Protein: 1133-1309
Range on HMM: 97-278/302.0
QSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEFT---ISVREEWGH----QSFSRKLLLVRNNKNNMlRRLAH---FQV
  | ..|.  .| .| . ... .| |. ..|.||. ||.|. ..  |...||..|   .||...  .    .||    . ..|.| .. .       .. 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilaf

DGWSndditscNEGAIIN---TMNLVKTLqrKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYK
 .|        . ||  .   .....|    .|  . ||.|||. .||.  . |    ..  .   | |. . |. .|    ||||.. |  
sawp.......dhGapkeaytaldilkfc..esykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
fn3 Fibronectin type III domain 134-223 2.4e-12 40.0 Pfam-A 3-85 (85) alignment 
Range on Protein: 134-223
Range on HMM: 3-85/85.0
PEAISVTPVssNATALLIDWEEPQNGSTGVVEYIVHYQPTNVSTncpgVKNGTIITNSINtSLLLTGLEENTNYTITISTISEAAVGEPS
|| .||..|  ..| | . |..|..|.  .. | |.|.... .     ...   .... . |. ||||...|.|.... ....|  |..|
Penlsvsev..tstsltlsWsppkdgggpitgYeveyrekggge....ewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1123-1319 6.5e-12 39.7 In-house 79-279 (303) alignment 
Range on Protein: 1123-1319
Range on HMM: 79-279/303.0
YKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG-TIEFGEFTISVREEWG---HQSFSRKLLLVRNNKNNMLRRLAHF
 . .|  |..| ||  |  |||.|| .. .  ...|    | ..      .|..   ..| | .| | |       . .. |.| | | . . .  . |.
ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhy

QvdGWSNDDITSCNEGAIINTMNLVKTLQR-KSPNTPVLMHCSNMIGRSAVF---C-AAMATVDQMKSSSVVDVFQTVKNMRVNlpgAVQNKGQYKMIHT
.   |  ..| |     ... .  .... |  |..|| .       ||.  |     | ..  ..  |  .| ....|.| |.    ||||  |. ...|
k..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlh...avqnlsqfsvvyt

LAAAYV
| | .|
llaehv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1121-1193 7.5e-12 39.3 In-house 82-166 (392) alignment 
Range on Protein: 1121-1193
Range on HMM: 82-166/392.0
QSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGE----EEACAQY----WPKEG----TIEFGEFTISVREEWG
.|..|.| .| .|.|   .  |||.|.|. ..|||.|.. . ||.      ..||.    || ..    |  . .|   |. ..|
psfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewPdkdvpkhtssllkfikevkadfG
I-set Immunoglobulin I-set domain 618-701 9.6e-12 36.5 Pfam-A 4-90 (90) alignment 
Range on Protein: 618-701
Range on HMM: 4-90/90.0
GKPPTEVHAIEGQEVVLKVRFHGDPTPKLSWKQDGEEIDWENCSFMLKN---GAIVFPYVEVAHSGEYEVTGSNDNGSESVSIVLTV
 .....| . ||..| |...  |.|.|. ||..||.|.  ..   . ..     ...  |||. .|.|... .|  |... .. |.|
tqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
0048076 (Phosphotyrosine protein) phosphatases II 1202-1315 1.2e-11 40.0 In-house 34-139 (145) alignment 
Range on Protein: 1202-1315
Range on HMM: 34-139/145.0
LLVRNNKNNMLRRLAHFQVDGWSNDDITSCNeGAIINTMNLVKTLQRKspNTPVLMHCSNMIGRSAVFCAAMatvdQMKSSSvVDVFQTVKNMRVNLPGA
| . .....  |   ...  .|   .. .     ... ..........  . ||| |||  .||.....||.     |.. . |....... .|   |||
lnltselellerlgiqylylpwpDhgvpdll.ellleflefieealke..ggpvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqrpga

VQNKGQYKMIHTLA
|.| ||..... . 
vpnpgqlrflyefe
subfamily_hpo-7_pd Subfamily hpo-7 1137-1282 2.2e-11 38.2 In-house 44-188 (263) alignment 
Range on Protein: 1137-1282
Range on HMM: 44-188/263.0
RETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKE--GTIEFGEFTISVREEWgHQSFSRKLLLVR--NNkNNMLRRLAHFQVDGWSNDDITScN
 .|   |...|   . ...|||.   | . | | .|.| |  .   . . .... .   ..   . | |.   ..    .. . |..  || .      .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvq.sdvllktlellstlge.KkkthtvkhysykgWiekndpe.l

EGAIintMNLVKtLQRKSpnTPVLMHCSNMIGRSAVFCAAMATVDQM----KSS
   |   .|..| . |.|   .. .|||. ||||| |  |     .|    . .
arei...lnilk.varns..kslvvhcstGiGrsaafsvaElvyqkmirsldtt
fn3 Fibronectin type III domain 451-520 2.3e-11 36.8 Pfam-A 8-76 (85) alignment 
Range on Protein: 451-520
Range on HMM: 8-76/85.0
VSEVNSTSVNVTWTPTA--NRDVTQYVLYYNSSTDNSpgETSSMNITGHQSsFVVLTGLDNSATYTFAIAAA
||||.|||....|.| .  ....| | . | ......  |. . .......  |.||||  ...|.| ..| 
vsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprttt.svtltgLkpgteYefrVqav
0048179 (Phosphotyrosine protein) phosphatases II 1217-1314 2.8e-11 38.9 In-house 51-140 (144) alignment 
Range on Protein: 1217-1314
Range on HMM: 51-140/144.0
HFQVDGWsnDDITSCNE-GAIINTMNLVKTLQRksPNTPVLMHCSNMIGRSAVFCAAMatvdQMKSSSvVDVFQTVKNMRVNLPGAVQNKGQYKMIHTL
...  .|  .|    .    .............  .. ||| |||  .||.....||      ||    ........ .|   ||||.| ||..... .
qylhlpw..pDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLley
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 793-881 3.6e-11 37.0 In-house 90-173 (349) alignment 
Range on Protein: 793-881
Range on HMM: 90-173/349.0
HTYVNASYIMVNKDDeQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSrgsEDYGPFTVTLQKeTTSNSF
. |.|| |. . . .   .|||||| ||  || ||....  ..   .. |.. .|    || .||      .|  .|| ||  .  .. 
ddyinanylkltris.vekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe...lsysnitvklqn.sslyia
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 916-999 4.1e-11 37.2 In-house 237-341 (350) alignment 
Range on Protein: 916-999
Range on HMM: 237-341/350.0
PINSLVKFNKII------SNQTEHKKGPIVVHCSTGGGRTGAFIGMSCSIK-----DALTESI----------IDIPAVVTIMREQRMMMIQTLDQYMLV
 ...|   |..|      |   . .  ||.|||| | |||| .. .   ..     . ||.              |  .| ..|.||. |.|.|||.. .
ilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifi

HEAVL
.||.|
Yeall
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 818-993 6.7e-11 36.2 In-house 98-279 (302) alignment 
Range on Protein: 818-993
Range on HMM: 98-279/302.0
GPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRIKCSQYWPSRG--SEDYGPFTVT-------LQKETTSNSFIIRELTLHVSGSAQ-STLLITHYQFID
 |   |.  .| .. | . . .| |... ||   ||..|.  .      .| .||.       |.. |  .|| .  . .. .   .     .   .|  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WLEYG-PQPPINSLvkfnKIISNqTEHKKGPIVVHCSTGGGRTGAFIGMSCSIKDALTESIIDIPAVVTIMREQRMMMIQTLDQYML
| ..| |. . ..|    .|.    |  |  ..||||.| ||||... .   |.  ... . |.  .|. .|. |   .|. .| . 
wpdhGapkeaytal....dilkf.cesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1128-1230 1.9e-10 34.8 In-house 138-237 (244) alignment 
Range on Protein: 1128-1230
Range on HMM: 138-237/244.0
GFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEeacaqYWPKEGTIEFGEFTISV--REEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWSN
 .|..| || .|  |||||...| .  .|.|  . | .|     |||    .|. |  |.|   .    .      | .  . |.  . |. ||.  |  
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps

DDITS
|  | 
dgttp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1121-1187 3.8e-10 33.7 In-house 230-294 (440) alignment 
Range on Protein: 1121-1187
Range on HMM: 230-294/440.0
QSYKNDKGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPImegEEEACAQYWPKE-GTIEFGEFTIS
. | . . || .| ||  |  |||... | .|.||.||  .   .. .|. ||| .  .. || ||. 
egyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpftvg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1127-1230 6.2e-10 33.5 In-house 28-128 (130) alignment 
Range on Protein: 1127-1230
Range on HMM: 28-128/130.0
KGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEeacaqYWPKEGTIEFGE--FTISVREEWGHQSFSRKLLLVRNNKNNMLRRLAHFQVDGWS
. .. .| || .|  |||||...| .  .|.|  . | .|     |||    .|. |   .... .  . .    . | . .. |.  . |. ||.  | 
aeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikasnleiesdlneshqaltmfqisnwp

NDDITS
 |  | 
sdgttp
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1127-1180 8.7e-10 32.6 In-house 94-147 (310) alignment 
Range on Protein: 1127-1180
Range on HMM: 94-147/310.0
KGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEGTIE
. || .| ||. |  |||.|||.    .|..|  ..|     |  |||  |  |
stficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1256-1313 9.4e-10 32.8 In-house 2-59 (69) alignment 
Range on Protein: 1256-1313
Range on HMM: 2-59/69.0
LMHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
..|||   ||.  | | |  . ..||  .||.|  |. ||   |  | |. .| .|| 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihd
subfamily_eak_pd Subfamily eak 1129-1240 1e-09 32.3 In-house 95-207 (332) alignment 
Range on Protein: 1129-1240
Range on HMM: 95-207/332.0
FIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPKEG--TIEFGEFTISVREEWGHQSFSRKLLLVRnnKNNMLRRLAHFQVDGWSND
.|..  .  .    ||.|....   .||.|   .| . |   .|.|...   ..|| . .  .|   .. .  .|| ..  | |   |. |..| ||.. 
yiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllels..kGnethrvlhykvfGwtet

DITSCNEG-AIINTM
..   ..  |. ..|
tlpkyedflalrkvm
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1257-1313 1e-09 32.6 In-house 2-58 (69) alignment 
Range on Protein: 1257-1313
Range on HMM: 2-58/69.0
MHCSNMIGRSAVFCAAMATVDQMKSSSVVDVFQTVKNMRVNLPGAVQNKGQYKMIHT
.|||   ||.  | | |  . ..||  .||.|  |. ||   |  | |. .| .|| 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihd
subfamily_CG42327_pd Subfamily CG42327 1247-1319 1.4e-09 32.1 In-house 242-315 (319) alignment 
Range on Protein: 1247-1319
Range on HMM: 242-315/319.0
QRKSPNTPVLMHCSNMIGRSAVFCAAMATVDQMKSS-SVVDVFQTVKNMRVNLPGAVQNKGQYKMIHTLAAAYV
 ... . |. .|||. .||. .  |.  .. ... |   ||. |.|  .| .   ||..| ||..|.  .  | 
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 761-908 5.4e-09 30.0 In-house 94-230 (244) alignment 
Range on Protein: 761-908
Range on HMM: 94-230/244.0
DENKPFNRNQNIVPYDVNIIELEplpRfLDCQHTYVNASYIMVNkddEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDlrikcSQYWPSR
 .|   ||.   .|.|.| . |    .      ||.|||..       .  .|| || ||  | .|||.|. . .   .|.|  ..|.      .|||  
pnnswknregaglpfdfnrvpls...k.gsmgntyinasfvgcl...grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpds

-GSEDYG-PFTVTLQKETTSNSFIIRELTLHvSGSAQSTLLITHYQFIDW
   | |    ||||            .| .  |   .|   .| .|  .|
eplewyeeditvtltdrdefknikasnleie.sdmneshqaltmfqisnw
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 790-851 5.9e-09 29.9 In-house 67-125 (347) alignment 
Range on Protein: 790-851
Range on HMM: 67-125/347.0
DCQHTYVNASYIMVnkdDEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDLRI
|  .||.|||.|     |.  ..|| || ||  || |||.||   |   .| . . ..|  |
ddvetyinashikf...dnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeai
fn3 Fibronectin type III domain 238-317 1.9e-08 27.5 Pfam-A 2-80 (85) alignment 
Range on Protein: 238-317
Range on HMM: 2-80/85.0
PPLNVTAYPINPSSINITWEPPLchLQNGPIRSYEI-AQTVIRFDHTNTIPVAAGQLSYMLTGIPSFRNNSIIVSVKNDNG
.| |... .....|....|.||    ..||| .||.  ...   ...... | . . |..|||.   .. .. |   |..|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag
Ig_2 Immunoglobulin domain 620-694 2.5e-08 25.8 Pfam-A 7-72 (80) alignment 
Range on Protein: 620-694
Range on HMM: 7-72/80.0
PPteVHAIEGQEVVLKVRFHGDPTPKLSWKQDGEEIDwENcsfmlKNGaIVFPYVEVAHSGEYEVTGSNDNGSES
||  ... ||. |.|  ...|.||||..|..||||.. ..     .|. .  | |.. .|| |. ..||..||..
pp..tvvtegenvtLtCqapgnptpkvqwykdgeels.qs.....qna.lfipnvsaedsGtYtCrasnsegskq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1127-1296 3.7e-08 27.4 In-house 82-256 (312) alignment 
Range on Protein: 1127-1296
Range on HMM: 82-256/312.0
KGFIIAQSPLRETRRDFWKMIFDREITTIVMLSPIMEGEEEACAQYWPK-EGTIEFGEFTI---SVRE-EWGHQS---FSRKLLLVRNNKNNMLRRLAHF
. |...|.|| .|   ||.. .    |.|..|. ..|   | ||.|     | ... .  .   .. | | | .|    . ..| |  .      .| |.
erfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhy

QVDGWSNDDITSCNEGAiintMNLVKTLqrKSPNTPVLMHCSNMIGRSAVFC---AAMATVDQMKSSSVVDVFQTVKNMRV
|   | .  .    . |    . |. ..  |  . ||. |||  .||.  ..   . .|.. . .   | |.|  ... | 
qwaswpdhgmpdscdta....lrllsav..kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdra
subfamily_PTPDC1_pd Subfamily PTPDC1 900-996 7.5e-08 27.0 In-house 83-170 (182) alignment 
Range on Protein: 900-996
Range on HMM: 83-170/182.0
ITHYQFiDWLEYGPqPPINSLVKFNKIISNQTEHKkgPIVVHCSTGGGRTGAFIGMSCSIKDALTESiidipAVVTIMREQRMMMIQTLDQYMLVHE
|..|.|  | .||  .......   |...   ...   . |||  | ||||  |      .. || .       ....|..|   ||| .|  ||.|
iyvynf.gwkDygv.asleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 746-999 9.9e-08 24.9 In-house 54-306 (346) alignment 
Range on Protein: 746-999
Range on HMM: 54-306/346.0
KRLGVPDLpTDIASSDENKPFNRNQNIVpyDVNIIELEPLPRFLDCQHTYVNASYIMVNKDdEQGQKYIATQGPL---DRTVVDFWRMVWQEKACaIVML
.| |.| .  |    . |.| . . | .  ....| |. . | . |  .||.   . .    .  .| | .| |    .  | ||| |..||.   .| |
nregcpki.ydenrvqlnrpghedvnyi..nasvitlkdvsrrmacvpayvhlvvlyfvif.qfehklivaqlpqmenesfvedfwymiyqeqih.lvyl

TKLQEDLR-IKCSQYWPSRGSEDYGPfTVTLQKETTSNSFIIRELTLHVSGSAQSTLLITHY-QFIDWLEYGpQPP-INSLVKF-NKIISNQTEHKKGPI
   .. |.    | .    |  .|    . ...  .  |   .| |. |    .|  .| .  .   |     |||    ..|.  .. |..  .. |  
mvpddklkntttslfndenggyqytg.kmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlq.qppktlpiikmihqflsekqvqnagvc

VVhCSTGGGRTGAFIGMSCSIKDaLTESI-IDIPAVVTIMREQRMMMIQTLDQYMLVHEAVL
||    | ||. .|||   .|.. | . |  .|  ..  ...||   .... ||  ..  |.
vv.slfgcgracsfigalyainq.lnngiepniceimknikqqrpggvesfaqyasiyaivf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 793-1003 1.3e-07 25.5 In-house 69-280 (303) alignment 
Range on Protein: 793-1003
Range on HMM: 69-280/303.0
HTYVNASYIMVNKDdeqgQKYIATQGPLDRTVVDFWRMVWQEKA-CAIVMLTKlQEDLRIKCSQYWPSRgsEDYGPFTV------TLQKETTSNSFIIRE
 .|. |||. .. .    .| | || ||  |  |||.|. ..|  | ...||   |  ..     .|    .|.  |         ...   .. . .. 
ssyihasyleldss....kkailtqlplshtaadfwqmiieqkvkcvlllltd.seydklggdsvfprn..qdflkfeersirvgefkrvelgdgwvlkv

LTLhVSGSAQSTLLITHYQfiDWLEyGPQpPINSLVKFNK----IISNQTEHKK-GPIVVHCSTGGGRTGAFIGMSCSIKDAL-TESIIDIPAVVTIMRE
|..   |. .| | . ||.  .|   .   | ..  || |    . |    . .  | |    .| ||.|.|  .  .       .. .|.  ..  .|.
lsv.sngdyksflhvhhyk..awph.nsi.psdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrn

QRMMMIQTLDQYMLVHEAVLEQAL
 |.  .| | |. .|.  . |. |
grlhavqnlsqfsvvytllaehvl
0038934 (Phosphotyrosine protein) phosphatases II 903-955 2.1e-07 26.3 In-house 82-135 (194) alignment 
Range on Protein: 903-955
Range on HMM: 82-135/194.0
YQFIDWLEYGPQPPINSLVKFNKIISNQTEH-KKGPIVVHCSTGGGRTGAFIGM
|  . . ..|. |... | .| ...   ..  ..| ..|||  | |||| ... 
ylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 931-1000 2.8e-07 24.2 In-house 261-342 (349) alignment 
Range on Protein: 931-1000
Range on HMM: 261-342/349.0
TEHKKGPIVVHCSTGGGRTGAFIGMSCSIK--DALTESI--ID--------IPAVVTIMREQRMMMIQTLDQYMLVHEAVLE
 . .  ...||||.| |||| .. .   .     |..    |.        |  .| ..| ||. |.| | |.. ..||.|.
dtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 774-912 3.4e-07 24.6 In-house 4-125 (130) alignment 
Range on Protein: 774-912
Range on HMM: 4-125/130.0
PYDVNIIEleplprfldcQHTYVNASYIMVNkddEQGQKYIATQGPLDRTVVDFWRMVWQEKACAIVMLTKLQEDlrikcSQYWPSRGSEDYGPFTVTLQ
...|. ..          ..||.|||.. .    .. ..|. || ||  | .|||.|. .     .|.|  ..|.      .|||     ..    ... 
efevsrlq..........gntyinasfvGll...grtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivt

KETTSNSFIIRELTLHVSGS-AQSTLLITHYQFIDWLEYG
     ..  |.   |...    .|   .| .|  .|   |
ltdrdefknikasnleiesdlneshqaltmfqisnwpsdg
0048567 (Phosphotyrosine protein) phosphatases II 880-955 4.3e-06 21.2 In-house 8-97 (157) alignment 
Range on Protein: 880-955
Range on HMM: 8-97/157.0
SFIIRELTLHVSGSAQSTLLITHYQF-IDW--------LEYGpQPPINSLVKFNKIISNQT---EHKKGPIVVHCSTGG---GRTGAFIGM
. || .  . ...    . | . ..| ||          ..|  .... |..|.... .     |.....|.|||..|    |||. .|| 
ieiipdrlyfallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc
subfamily_DSP23_pd Subfamily DSP23 906-996 8e-06 20.6 In-house 57-140 (148) alignment 
Range on Protein: 906-996
Range on HMM: 57-140/148.0
IDWLEYGPqPPINSLVKFNKIISnQTEHKKGPIVVHCSTGGGRTGAFIgmSCSIKDaltESIIDIPAVVTIMREQRMMMIQTLDQYMLVHE
.   .| | | .. .|.| ...  ..|.|.  . |||  | ||||...  .| .     |  .     .. .|..|   ..|..|  ||..
lriddyhp.paleqvvefvrvve.eaeekneavsvhcllgrgrtgtml..acylvk...erklaaaeaiaevrrlrpgsvetveqeklvrd