Gene PTPRD-4 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP095_AA protein Get Run
AqueP095_AA_1025-1306 phosphatase_domain Get Run
AqueP095_AA_1312-1568 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1022-1320 5.4e-189 623.2 In-house 1-294 (439) alignment 
Range on Protein: 1022-1320
Range on HMM: 1-294/439.0
HVGRDEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPK
||||||||||||||||||||||.||||.||||||||||||||||.|||||||||.|||||||||||||||||||||||||||.||||.||||||||||||
hvgrdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpk

EETTDDFWRMVWEQRTVTIVMLTNLMESYKskchqYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASH
.||||||||.|.|..||||||||||.||||     ||||....||||||||||||||||.|.||||||||||||||||||||||||.||||.||||||||
kettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqash

VLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDR
|||||||||||||||||||.||||||||||||||||||||||||||||||||||||..|||||||||||||||.||.||.||||||||.|||||||| .
vldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkke
subfamily_PTPRD_pd Subfamily PTPRD 1025-1334 1.1e-120 399.0 In-house 7-316 (564) alignment 
Range on Protein: 1025-1334
Range on HMM: 7-316/564.0
RDEFQEHVEKLDKNKQEIFNEIFEFINSTsPDYAciASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEET
 .|..|||.||..|..  |.| .. |..  .      . |...  . |||| .. |.||.|| |....|.. |.||||.||.||. .| |||||||..||
vaelkehvaklkansdlkfeeeykkieeg.qqft..weaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaet

TDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVfnERDTTEKERTVLQFHYTAWPDRNVPAQASHVLD
..|||||||||.. ||||||.| |. | |||.|||..|.. ||.. | .  . || .|.|| ||.  .. .... |.| |||.|.|||..|| .| ..||
iedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpesatslLd

FLRAINSANdKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKL
..| ....| ... |||||||||||||||| |..|. ||..| |..||| ..|. |||||. |||  .||||||.|||| .  |.| |.....|.. .||
lirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

QEP------TLINEEF
.|       | .. ||
aeveedtemtgleleF
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1026-1327 2.4e-105 347.1 In-house 5-302 (318) alignment 
Range on Protein: 1026-1327
Range on HMM: 5-302/318.0
DEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASlaAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETT
.....||..| .. .  ..| .| .. ..   . . |   .. ...|||| .. |.||||| ||.. |.. | |||||.| ||. .| |||.|.|  || 
edleshvrrlresGelllseeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpeti

DDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNerDTTEKERTVLQFHYTAWPDRNVPAQASHVLDF
.||||||||| . .|||||...|. | |.|.||||.|   ||.. | .. ..|| .|..| ||| .  . .|..|.| |.|||.|||..||......||.
eDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpesgaslldl

LRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKLQ
.| ...|. |...|||||||||||||||. ||.|| ||..| |. ||. ..|. ||.||. |||.  ||.||....|| .  ||| |  .....|  .|.
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr

EP
|.
eq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1425-1584 5.5e-102 336.4 In-house 278-439 (439) alignment 
Range on Protein: 1425-1584
Range on HMM: 278-439/439.0
QLKFGPLTVSVGR--KQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESCHRGNHPILIHDDGSNGPVGIFATLAY
....| ..|....  |.||.||||||||||||||||.|||||||||||||||||||.|||||||||||||.|||||||||||||||||||||||||||||
divyGdiavtidefkkefnagfstrdisifneedssllklkyiqyqemllkqcfprvdkfikfiqgclveveschrgnhpilihddgsngpvgifatlay

CLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYSDKLLKEESLPPIYENIA
|||||||||||||||||||||||.|||||||||||||||||||||||||||||||.||||||
clqrakkeriidllqsanhhylqspglivnlqfyaycydclleysdkllkeeslpsiyenia
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1026-1326 5.3e-99 326.3 In-house 8-304 (319) alignment 
Range on Protein: 1026-1326
Range on HMM: 8-304/319.0
DEFQEHVEKLDKNKQEIFNEIFEFINSTSPDyacIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETT
.|..|....|... .  ... |. .. ...|     . | .| ...||||... |.|.|||.|.|..||. | ||||.|| ||.. . .||||.|.|.|.
qeLkerlkalastgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

DDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVfNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDF
.||||||||... ..||||.| |  | |...|||.     || . | .. . || .| || .|. |.. .  . |.| .|.||.||| .|| .|  .||.
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldl

LRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKLQ
|. |. . .|.. |||||||||||||||| |.||..||..|.|. .|.  .|  || ||. |||   ||.||..|.|| .  ||| . .....|| ..|.
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

E
|
e
0051299 (Phosphotyrosine protein) phosphatases II 1022-1303 1.9e-96 318.2 In-house 4-284 (288) alignment 
Range on Protein: 1022-1303
Range on HMM: 4-284/288.0
HVGRDEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACiaSLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPK
..  .|. ..|.|| .| . .. | || . |  ||. .  | |...  ..||||.|. ..||.|| |. ..||..| ||||..|.||. .. .||||||.
eisveellklvlkllangltglleefeellsllpdltl..saallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

EETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNE--RDTTEKERTVLQFHYTAWPDRNVPAQA
..|..|||||||||.. .|||||.|.|  . ||.||||..|  .|||| |.  .  .|..||.| ..| |    | ....||| .||||.||| .||  .
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

SHVLDFLRAINSANDkEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
...|||||....|.     ||.|||||||||||||.||||..||||. |..||. ..| .||.|| .||| ..||.|.. |.||
ellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_PTPRA_pd Subfamily PTPRA 1025-1325 1.6e-95 314.8 In-house 16-315 (330) alignment 
Range on Protein: 1025-1325
Range on HMM: 16-315/330.0
RDEFQEHVEKLDKNKQEIFNEIFEFINSTSpdYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEET
 ....| ...   .  . | | |. . ...    .   ||..| .. |||. ..  .|..|| |... ||..| |||| ||.||.. . .||.|||||||
vekleeeirirsaddnklfreefnalPagp..iqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeet

TDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTT--EKERTVLQFHYTAWPDRNVPAQASHV
 .|||||.|||.. ||||||.| |  ..||.||||. |   ||.| | |. . .| .||.| | | .  |.|  .|.| | |||.|.|||  ||...  .
vedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGm

LDFLRAINSANDKEEYgPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCM
|..|..... |...   ||||||||||||||| |.||  ||..| |.|||. ..|  ||.|| ||||.. || ||....||  .|||| . .  .. .  
lkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlq

KLQ
||.
kly
subfamily_PTPRB_pd Subfamily PTPRB 1023-1303 2.6e-95 313.8 In-house 7-283 (293) alignment 
Range on Protein: 1023-1303
Range on HMM: 7-283/293.0
VGRDEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIAslAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKE
.  ..|.|||.|. .. .  |.| .| ...   | |. |  | .. ...||||... ..||.|| |... . ..| |||||.|.||.  . .||||||  
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavka..aelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

ETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS-GQCCYGDIAVRVDRNIELPHYTIRGFKVFNerdtTEKERTVLQFHYTAWPDRNVPAQASH
||.|||||||||... .|||||.|.|  | ||..|||.   .. |||| | .  . || ...|| .|. .    ...||.| |.|.|.||| .|| ... 
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektkt

VLDFLRAINSAN-DKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
.|||.|....|  .... .||||||||||||||| ||||  |.... |. ||| |||. ||..|...||.  ||||||...|.
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
0040438 (Phosphotyrosine protein) phosphatases II 1028-1339 7.5e-93 306.5 In-house 5-310 (317) alignment 
Range on Protein: 1028-1339
Range on HMM: 5-310/317.0
FQEHVEKLDKNKQEIFNEIFEFINSTSPDyacIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDD
. .....|.|.   .. | || . | ..|     | |...  . ||||.|.  .||.|| |. ..|...| ||||....|..  . .||||||...|..|
lllalldllksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLR
||||||||.. .|||||.|.|  . ||.||||. .   |||. |..   .||...|.| ..| .    ....||| .||||.||| .||   ...||||.
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfle

AINSANDkEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKLQEP
|...|.. .. ||..||||||||||||.||....||||. |..||.. .| .||.|| ..|| . ||.|.. |.|| . ...| . . |.| ...||..|
avreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllip

TLINEEFNKIGS
  ... ..|. .
lalddvklkeke
0050432 (Phosphotyrosine protein) phosphatases II 1021-1307 1.3e-92 305.8 In-house 24-301 (308) alignment 
Range on Protein: 1021-1307
Range on HMM: 24-301/308.0
EHVGRDEFQEHVEKldKNKQEIFNEIFEFINSTSPDYACiaSLAAHEYDQTKNRYRDVGAFDHTRVTLqeipGvPHSHYINANFIKGY--HDDKLYIATQ
...  ... ...||  ..   ...| || ..|. |.. .  | |...  ..||||.|. ..||.|| |    . ..|.||||....||  . .. .||||
lklsvldllkllek..aldlglleeefeellsvkplley..svallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatq

GPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS---GQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTteKERTVLQFHYTAWPDRNV
||...|..|||||||||.. .|||||.|.|  . ||.||||..   |  .||.. |.. .  .|..||.| ... | .|   ..||| .||||.||| .|
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthfhytnWpdhgv

PAQASHVLDFLRAINSANDKeeyGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVY
| .....||||..... ...   ||||||||||||||||.||||..||||. |..||. ..| .||.|| .||| . ||.|.. |.|| . .
Ppspeilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Ptp69D_pd Subfamily Ptp69D 1023-1324 5.4e-91 299.9 In-house 4-305 (307) alignment 
Range on Protein: 1023-1324
Range on HMM: 4-305/307.0
VGRDEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACiaSLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKE
. .|. .| ... ... .. . . .| ....  |  .  . .... .. |||| |. |||.||| |..|.|  .| ||||.|||||.. | .|| |.| |
iaiddleealksrkrdtdfglakeyekLeareidkst..kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTT---EKERTVLQFHYTAWPDRNVPAQA
.| .|||||..||   .||||.|| |  . ||..|||   .. |||| |.. .. . ..|.|| ..| .  ...   |..| |.|.|||.|.| .|| .|
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

SHVLDFLRAINSANDKEeYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKD
  .|.... ... . ..  .||||||||||||.|...|||. |.|||.|.||||  .|  ||.||. .|| | ||.|.. |.|. . |||| ...|...|
rgllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

RCMKL
.  .|
aierl
subfamily_PTPRG_pd Subfamily PTPRG 1026-1322 9.6e-91 299.7 In-house 4-306 (563) alignment 
Range on Protein: 1026-1322
Range on HMM: 4-306/563.0
DEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHS-HYINANFIKGYHDDKLYIATQGPKEET
.||..|| .|  . .  |.| || ..|.. .    |. . .. .. |||| .. |.|..||.|...||. ..  |||||.|.||.  | .|||||| ..|
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

TDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFN----ERDTTEKERTVLQFHYTAWPDRNVPAQAS
.||||||.|||.. .|||.||| |. . ||..|||. .   || . |.  ..  |  ||.| ... |    . . ...|..| |.||| ||| .|| .. 
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl

HVLDFLRAInSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKD-
 || | .   ||  |.| |||||||||||||||| |.||  |.|.. ||.|.. |..  .| ||  .||   ||||.|.|.|| |  ..| .. .. .. 
pvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveel

-RCM
  | 
knct
0046845 (Phosphotyrosine protein) phosphatases II 1046-1308 9.9e-91 299.3 In-house 5-277 (284) alignment 
Range on Protein: 1046-1308
Range on HMM: 5-277/284.0
IFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGV-PHSHYINANFIKGY-----HDDKLYIATQGPKEETTDDFWRMVWEQRTVT
 || ..|  ... .  | |...  ..||||.|. ..||.|| |. ..|  ..|.||||....||     .  | .||||||...|..|||||||||.. .
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

IVMLTNLMESYKSKCHQYWPSSG-QCCYGDIAVRVDRNIELPHYTIRGFKVFNErDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDK-EE
|||||.|.|  . ||.||||..|    |||. |.. .  . ..||.| ... |. ..|...||| .||||.|||..||......|.|||........ . 
IVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

YGPIVVHCSAGVGRTGTIIALDIALEQLKLEN---KVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYG
 ||||||||||||||||.||||..||||. |.   .||. ..| .||.|| .||| | ||.|...|.|| . ..
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0039614 (Phosphotyrosine protein) phosphatases II 1027-1305 4.2e-87 287.6 In-house 18-289 (297) alignment 
Range on Protein: 1027-1305
Range on HMM: 18-289/297.0
EFQEHVEKLDKNKQEIFNEIFEFINSTSPDyaciASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGV-PHSHYINANFIKGYHD-DKLYIATQGPKEET
 .  .. ....|.  .. . || . |  ||     | |...  ..||||.|. ..||.|| |. ..|| ..| ||||....||.  .. .|||||| .||
vldlllllekansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

TDDFWRMVWEQRTVTIVMLTNLMESYKsKCHQYWPSSGQcCYGDIAVRVDRNIELPHYTIRGFKVFNerdtTEKERTVLQFHYTAWPDRNVPAQASHVLD
..|||||||||.. .|||||.|.|  . ||.||||..|. .|||. |.. . ..|..||.| ..| |    ....||| .|.|| ||| .||  ....|.
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslellle

FLRAINSANDKE-EYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDI
||.....|. .  . ||..||||||||||||.||....||||. | .||.. .| .||.|| ..|| . ||.|...|.|| .
flelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0036941 (Phosphotyrosine protein) phosphatases II 1034-1318 7.9e-87 286.6 In-house 6-290 (297) alignment 
Range on Protein: 1034-1318
Range on HMM: 6-290/297.0
KLDKNKQEIFNEIFEFINSTSPdyACIASLAAHEYDQTKNRYRDVGAFDHTRVTLqeipGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVW
. ...   .. . || . .  .   .  | |. .  ..||||.|. ..||||| |    . ..| ||||....||. .. .||||||...|..|||||||
lekllflalllkefeellplll..lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

EQRTVTIVMLTNLMESYKSKCHQYWPSS--GQCCYGDIAVRVDRNIE--LPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAI
||.. .|||||.|.|  . ||.||||.   .  .|||. |.. .  .  |..||.| ..| .    ....||| .|||| ||| .||  ....|||....
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielv

NSANDKE-EYGPIVVHCSAGVGRTGTIIALDIALEQLK---LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFK
......  . ||..|||||||||.||.||.|..|.||.    |..|||. .| .||.|| ..|| | ||.|.. |.|| . ...| . .....
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklv
0047943 (Phosphotyrosine protein) phosphatases II 1037-1303 7.9e-87 286.5 In-house 8-270 (273) alignment 
Range on Protein: 1037-1303
Range on HMM: 8-270/273.0
KNKQEIFNEIFEFINSTSPDYACiaSLAAHEYDQTKNRYRDVGAFDHTRVTLqeipGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQR
..   .. | || . |. |.. .  | |...  ..||||.|. ..||.|| |    | ..|.||||....||.  . .||||||...|..|||||||||.
llgltllleefelllslkpllty..svallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

TVTIVMLTNLMESYKSKCHQYWPSSG---QCCYGDIAVRVDRNIELPHYTIRGFKVFNERdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSAN
. .|||||.|.|  . ||.||||..|      ||.. |.. .  . ..||.| ... |    |...||| .|||| ||| .||.. ...|.|......|.
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg..tgesrtvthfhytgwpdhgvppslesllefielvrkal

DKE-EYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
 .  . ||.|||||||||||||.||||..|.||. |..||.. .| .||.||  ||| ..||.|...|.||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0043336 (Phosphotyrosine protein) phosphatases II 1024-1303 1.4e-86 285.7 In-house 3-275 (278) alignment 
Range on Protein: 1024-1303
Range on HMM: 3-275/278.0
GRDEFQEHVEKLDKNKQEIFNEIFEFINSTSPdyaCIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEE
.. ........| .| . .. . || ..|  .   .  | |...  ..||||.|. ..||.|| |. ..|...| ||||....||.  . .|||||| .|
svkdllkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPsSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNerDTTEKERTVLQFHYTAWPDRNVPAQASHVL
|..||||||||... ||||||.|.|  . ||.|||| .|  .|||. |.. . ..|..||.| ..| |    . ..|||...||..||| .|| . |..|
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslslll

DFLRAINSANDkEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
|||.|...|..  . ||..||||||||||||.|||...||||. | .||.  .| .||.|| ..|| . ||.|...|.||
dflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 1025-1303 3.6e-86 285.0 In-house 11-302 (307) alignment 
Range on Protein: 1025-1303
Range on HMM: 11-302/307.0
RDEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGV-PHSHYINANFI--------KGYHDDKLYI
.  .  .| .| ..  ... . || ..|  ... .  | |...  ..||||.|. ..||||| |. ..|  ..|.||||...        .||. .. .|
alkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfI

ATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC-CYGDIAVRVDRNIELPHYTIRGFKVFNErDTTEKERTVLQFHYTAWPDRN
|||||..|| .|||||.|||.. .|||||.|.|  . ||.||||..|.  .||.. |.. .  .|..||.| ..| .  | |...||| .||||.||| .
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhg

VPAQASHVLDFLRAINSANDKE-EYGPIVVHCSAGVGRTGTIIALDIALEQLKLENK---VDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||   ...|||......|...  . ||..||||||||||||.||....|.||. |..   ||.  .| .||.|| ..|| . ||.|...|.||
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1030-1307 6.8e-86 282.9 In-house 10-280 (288) alignment 
Range on Protein: 1030-1307
Range on HMM: 10-280/288.0
EHVEKLDKNKQEIFNEIFEFI-NSTSPDYACIASLAAheyDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDF
..| | ...... |.| .. . .  . .  ....||    ...|||||.. ..|..|| |.. . .. . ||||..|.|.. .| |||||||  .| .||
akvakksarnrtgfseeynsLaalektksvtagrlav...nakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndf

WRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQ-CCYGDIAVRVDRNIELPHYTIRGFKVFnerdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLR
|..|.|..| ||||||.|.|  |.||..|||....   ||.. | .  . || ... | . .      ...|... |..|.|||| .||...  .|..||
WelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellr

AINSANDKEeYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILeDIVY
 .. ||...  |||.|||||||||||| |||| ...... |...|. |.|. |||||...|| | ||.||....| ....
qvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll.slie
DSPc_SM00195 1047-1303 1.6e-85 282.0 In-house 6-260 (263) alignment 
Range on Protein: 1047-1303
Range on HMM: 6-260/263.0
FEFINSTSPDYaciA-SLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTN
|| ...  ..      . |...  ..||||...  .||||| |..... ..| |||||.|||.. .| |||||||...| .||||||||... .|||||.
fekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LMESYKSKCHQYWPSS--GQCCYGDIAVRVDRNIELP-HYTIRGFKVFNERDttEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEeYGPIV
 .|. | ||..|||..  |.  .|.| | . .... . ....| ... .| .  |..|.| |..|..|||..|| ....||..|||... ....  ||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||||||||||||....||.|..|. |.||||. ||. ||||| .||| | ||.||..||||
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 1047-1303 1.6e-85 282.0 In-house 6-260 (263) alignment 
Range on Protein: 1047-1303
Range on HMM: 6-260/263.0
FEFINSTSPDYaciA-SLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTN
|| ...  ..      . |...  ..||||...  .||||| |..... ..| |||||.|||.. .| |||||||...| .||||||||... .|||||.
fekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LMESYKSKCHQYWPSS--GQCCYGDIAVRVDRNIELP-HYTIRGFKVFNERDttEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEeYGPIV
 .|. | ||..|||..  |.  .|.| | . .... . ....| ... .| .  |..|.| |..|..|||..|| ....||..|||... ....  ||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||||||||||||....||.|..|. |.||||. ||. ||||| .||| | ||.||..||||
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1027-1312 2.1e-85 281.6 In-house 13-297 (298) alignment 
Range on Protein: 1027-1312
Range on HMM: 13-297/298.0
EFQEHVEKLDKNKQEIFNEIFEFINSTSPDY-ACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETT
 .|. ...  |.|   ... |. .||.| .  .   . | ..... |||| |. |.|..|| |... .  .| |||| |...|.. . .||||.| .||.
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

DDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTteKERTVLQFHYTAWPDRNVPAQASHVLDF
 ||||||.|.   |||||||| |. | |.|.|||..|.  ||.| |.. .. |   ...| .|| ... .  |||.| |.|.| |||. ||..|. |||.
edFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvldl

LRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAV
|| ..  . .    |..|.|||||||.|| ||.|  ||..| |..||.  .|  |||.| ..||.  ||.||..|.|| .  ... .
lrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1023-1325 2.8e-84 277.9 In-house 4-303 (305) alignment 
Range on Protein: 1023-1325
Range on HMM: 4-303/305.0
VGRDEFQEHVEKLDKNKQEIFNEIFEFINSTsPDYACIaslAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKE
.. |........  ..... ... .. . .. ..   .     .| ...|||....  .|. |. |.| . ...|.||||....||.  | ||..||| .
ialddlaayikearvysdkgleaqykslyee.eesidv...gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

ETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC--CYGDIAVRVDRNIELPHYTIRGFKVFNERDtTEKERTVLQFHYTAWPDRNVPAQAS
.| .||||...| ...||||||.|.|  |.||.|||| | .    .|.. | .  . . . |..| .|. .|..  ...|||||.. | |||  || .|.
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfat

HVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDR
 .|.... .. .  |..  |..|||||||||||. ||.|||||.|| |. ||. ...  ||..| .||| | || |.|.|. | |  ||| . .. .. |
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar

CMKLQ
  ||.
vnklk
subfamily_PTPRK_pd Subfamily PTPRK 1062-1322 3.5e-82 270.7 In-house 36-294 (314) alignment 
Range on Protein: 1062-1322
Range on HMM: 36-294/314.0
SLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS
  | .. ...|||. |. |.|..||.|. | | |.| ||||..| .|.  . .|.||||..||. ||||.|..... .|||||.|.|  . || .|||  
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GQCcYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKeEYGPIVVHCSAGVGRTGTIIALDIA
..  |||| | . .   |  . .| |.| .   . |. |.| ||....||| .|| .|  .|...| ... ... | |.|||||||| ||||| ||.|| 
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidiv

LEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCM
|. .. |. ||.  .|  ||...  ||..  ||.||...|||  . |.||. . |||   .
ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyl
Y_phosphatase Protein-tyrosine phosphatase 1070-1303 3.6e-82 270.7 Pfam-A 2-235 (235) alignment 
Range on Protein: 1070-1303
Range on HMM: 2-235/235.0
QTKNRYRDVGAFDHTRVTLQEIPGvpHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWP--SSGQCCYG
..||||.|. ..|.||| |.. .|  .| |||||..|||...| .|||||| ..| .|||||||.... .|||||.|.|. . ||.||||  ..... ||
kkknRykdilpydktrvklkgseg..psdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DIAVRVD-RNI-ELPHYTIRGFKVFNERDTTeKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANdKEEYGPIVVHCSAGVGRTGTIIALDIALEQL
|| |..  ..  .  .||.| ... .. . . ..|.| |.|||.|||..||......||..|.... . ... ||.|||||||||||||..||||.||||
dikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
. |..||.. ||  ||||| .||| | ||||...||||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1070-1303 3.6e-82 270.7 In-house 2-235 (235) alignment 
Range on Protein: 1070-1303
Range on HMM: 2-235/235.0
QTKNRYRDVGAFDHTRVTLQEIPGvpHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWP--SSGQCCYG
..||||.|. ..|.||| |.. .|  .| |||||..|||...| .|||||| ..| .|||||||.... .|||||.|.|. . ||.||||  ..... ||
kkknRykdilpydktrvklkgseg..psdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DIAVRVD-RNI-ELPHYTIRGFKVFNERDTTeKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANdKEEYGPIVVHCSAGVGRTGTIIALDIALEQL
|| |..  ..  .  .||.| ... .. . . ..|.| |.|||.|||..||......||..|.... . ... ||.|||||||||||||..||||.||||
dikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
. |..||.. ||  ||||| .||| | ||||...||||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1029-1305 4.9e-82 270.2 In-house 3-276 (281) alignment 
Range on Protein: 1029-1305
Range on HMM: 3-276/281.0
QEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAahEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDF
..|...|..|... | | .| ...   | .  || |  . ...||||... |.|.|||....     .. ||||||..||...| |||||||  .. ..|
rkhlkqlsqndnaGfieeyeklaaigvdntataska..denvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvaf

WRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSG-QCCYGDIAVRVDRNIELPHYTIRGFKVfnERDTtEKERTVLQFHYTAWPDRNVPAQASHVLDFLR
|.|||||.  .|||.|. .|. | |||.|||    .  |||. |.  .. | ..|  | ||.  ||..  ..|.| |..||||||  |||.....|.| .
WqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eres.getreveqlaytaWPdhGvPattkellefrk

AINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLE-NKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDI
.......|..  |.|.||||||||||| |||| ...... | ...|.| .|. |||.|. |||.. || |.. |.|. .
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1064-1306 6e-81 266.3 In-house 4-243 (250) alignment 
Range on Protein: 1064-1306
Range on HMM: 4-243/250.0
AAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSkCHQYWPSSGQ
| .  .. |||| |. |.|..|| |..  |  .| |||| |..||.. |..|||||| ..|. ||||||.|. . |||||||| || |  .|||||  . 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

CCYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALE
  |||. | .  . |   ||.| .|. ..  . ..||.| |.|...|||. ||..|  ||..|. ... ... . .|..|.|||||||.|. ||.|  ||
ekyGdvtvsllskeefadytkrklklska..kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

QLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIV
.|| |..||.  ..  |||.| ..|..| ||.|....||. ..
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
0042113 (Phosphotyrosine protein) phosphatases II 1064-1303 3.1e-80 264.4 In-house 4-241 (245) alignment 
Range on Protein: 1064-1303
Range on HMM: 4-241/245.0
AAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQ
|... ...||||.|. ..||||| |....| ..| ||||....||.  . .|||||| .||..|||||.||..  ||||||...|  . ||.||||... 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

CCYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALE
  |||. |.. .   |..||.| ..| |.   . ..|.|...||. ||| .||   ...||||.....|  . . ||..||||||||||||.||....||
ltygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

QLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||. | .|..  .| .||.|| ..|| . ||.|.. |.||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0040439 (Phosphotyrosine protein) phosphatases II 1065-1303 3.1e-80 264.6 In-house 7-244 (249) alignment 
Range on Protein: 1065-1303
Range on HMM: 7-244/249.0
AHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC
 .. .. ||||.|. ..||.|| |. .||...| ||||..|.||.  . .|||||| .||..|||||.||..  .|||||.|.|  . ||.||||..|  
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsl

CYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKE-EYGPIVVHCSAGVGRTGTIIALDIALE
 |||. |.. . .....||.| ... |    . ..||||...|| ||| .||   ...|||..|...|...  . ||..||||||||||||.||....||
eygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

QLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||. |..||.. .| .||.|| ..|| . ||.|...|.||
qlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_PTPN12_pd Subfamily PTPN12 1043-1303 5.1e-78 256.9 In-house 14-275 (290) alignment 
Range on Protein: 1043-1303
Range on HMM: 14-275/290.0
FNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVM
|... .  .    . .. .. . .|....||||.|.  .|..||.|..| ....| ||||||||| .... |||.|||  .| ||||||.||...  .||
fqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvm

LTNLMESYKSKCHQYWPSSG--QCCYGDIAVRVDRNIELP-HYTIRGFKVFNErdttEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDkEEYG
. ...|  | ||..|||..|  .. .|.. | ....  .   ..|| .|| ..    ...|.| |||||||||..||..|...|........ .. .|  
aCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.seda

PIVVHCSAGVGRTGTIIALDIALEQLKLEN---KVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
|.||||||||||||||||.|.. |.|| |.   ..|.  .|. |||||. .||.  || ....|..|
PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
0045098 (Phosphotyrosine protein) phosphatases II 1066-1303 7.7e-78 257.0 In-house 30-270 (278) alignment 
Range on Protein: 1066-1303
Range on HMM: 30-270/278.0
HEYDQTKNRYRDVGAFDHTRVTlqeipgvphsHYINANFIKGYhdDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCC
 . .. ||||.|. ..||.||            ||||..|.||  .| .||||||...|..|||||.||... .|||||.|.|  . ||.||||..|   
ylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

YGDIAVRVDRNIELPHYTIRGFKVFNE--RDTTEKERTVLQFHYTAWPDRNVPAQA--SHVLDFLRAINSAND------------KEEYGPIVVHCSAGV
|||. |..    .|..||.| ..| |   .... ..|.| ..||. ||| .|| .   ...|..|. |..|..             .. ||..|||||||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

GRTGTIIALDIALEQLklENKVDIKGIVTFLRKQRKQ-MVQALCQYIFIHNAILE
|||||..|... ||.|  |..||.  .|..||.|| . .|| | ||.|.. ..||
gRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1065-1327 8e-78 256.5 In-house 45-301 (315) alignment 
Range on Protein: 1065-1327
Range on HMM: 45-301/315.0
AHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSgQC
 .  .. |||| .. |.|..|| |  .   |||.|.|||||.||   . |||.|||. .. .||||.|.|.   .|||||||.|  |.|. .|||   . 
kkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kv

CYGDIAVRVDRNIELPHYTIRGFKVFNerdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEyGPIVVHCSAGVGRTGTIIALDIALEQ
 || |.|    .    .||.| . |       .. |.|.|.|||.||| .||. .  .... | ..  ....  |.|||||||||||||| |.||  |.|
iyGkitvtrkseevnteytvrtlsvvf....gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldq

LKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKLQEP
.. || .|.  ..| .|..|..|||.. || ||..|.|| .| |||... | . .|   |  |
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllap
subfamily_PTPN6_pd Subfamily PTPN6 1030-1303 8.5e-77 253.1 In-house 11-295 (306) alignment 
Range on Protein: 1030-1303
Range on HMM: 11-295/306.0
EHVEKLDKN----KQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQeIPGVPHSHYINANFIKGY--HDDKLYIATQGPKEE
..|..|.|.    ... |.| || .. .   .    . .|.   ..||||. .  ||||||.|.  |.|| | |||||.||.     || ||||||  |.
qrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclet

TTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQ-CCYGDIAVRVDRNIELPHYTIRGFKVFNeRDTTEKERTVLQFHYTAWPDRNVPAQASHV
|  |||||||.. .  |||.|. .|  |.|| .|||.. .   ||.| |.  .. .| .|..| ..| . ... ..||.| |.|...||| .||.. ..|
tvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvsk.kkkkkeerevfqyhfksWPdhgvpkdpgav

LDFLRAINSANDKEE---YGPIVVHCSAGVGRTGTIIALDIALEQLK---LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||||. .|. ... |    ||||||||||.|||||.| .|| |....   |. ..||. .|  .|.||...||   || |...|| .
LdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1063-1318 1.6e-76 252.7 In-house 55-304 (319) alignment 
Range on Protein: 1063-1318
Range on HMM: 55-304/319.0
LAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTnlmesyKSKCHQYWPSSG
 |  . .. |||. .. |||...| |. . |.  | |||| |..||   . |||.|||...| .|||||.||... |||.||      | || ||||  .
fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki

QCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTTeKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEE-YGPIVVHCSAGVGRTGTIIALDIA
.  ..   |.||   |   |..| ... ..   .   | . |||.  |||  || ..| .. ... ..  ..||.   .|||||||||||||. |.||. 
vikeerfkvkvdsveetaeyvvrdielsedgkek.dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvl

LEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFK
|...| |..||.  .|  ||.||...|| | || ||. |.||. ..| . |.. .| 
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfp
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1068-1319 8.6e-76 250.1 In-house 24-269 (284) alignment 
Range on Protein: 1068-1319
Range on HMM: 24-269/284.0
YDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTnlmesyKSKCHQYWPSSGQCCYG
 .. |||. .. |||...| |. . |.  | |||| ||.||   . |||||||...| .|||||.||... |||.||      | || ||||  ..  ..
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

DIAVRVDRNIELPHYTIRGFKVFNERDTTeKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEE-YGPIVVHCSAGVGRTGTIIALDIALEQLK
   |.||   |   |..| ... ..   . . |.. |||.  |||  || ..|... ... ..  ..||.   .|||||||||||||. |.||. |...|
rfkvkvdsveeseeyvvrdielsedgkek.dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmk

LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKD
 |..||.  .|  ||.||...|| |.|| ||. |.||. ..| . |.. .|  
eekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpa
subfamily_PTPN9_pd Subfamily PTPN9 1029-1303 2.1e-74 245.3 In-house 7-288 (297) alignment 
Range on Protein: 1029-1303
Range on HMM: 7-288/297.0
QEHVEKldKNKQEIFNEIFEFINStSPdyACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDF
 ..|..  |.|. . .| .|  |  ..  .  .  . .  . .|||| ||  .|.|||.|..... ..| ||||||. ||.  | .|||||| ..|..||
vayvke..kgkrGlskeyaeirne.pv..eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS--GQCCYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFL
|||||||....||| | ..|  . || ||||..   .  .||. |..    |  .|..| ... |   .||..|.|  | ...|||  || .|. .||.|
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknv..kteesrkvthfqflsWPdyGvPssaaslldvl

RAINSAND------------KEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
... ..              . .  |||||||||.||||| |.|||.|..|. ...||.   |  ||.||  ..|   || | . |.||
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0037934 (Phosphotyrosine protein) phosphatases II 1064-1303 6.9e-74 243.7 In-house 5-240 (243) alignment 
Range on Protein: 1064-1303
Range on HMM: 5-240/243.0
AAHEYDQTKNRYRDVGAFDHTRVTLqeipgvPHSHYINANFIKGYhdDKlYIATQGPKEETTDD----FWRMVWEQRTVTIVMLTNLMESYKSKCHQYWP
| ......||||.|. ..||.|| |      . | |||||.|...  .. .|||||| .||..|    ||||.||... .|||||.|.|  . ||.||||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

ssGQCCYGDIAVRVDRNIELPHYTIRGFKVFNeRDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDK-------EEYGPIVVHCSAGVGRT
  |. .|||. |..    .|..||.| ... |  |... .|.| ..||..||| .||   ...||||.....  ..        . ||..||||||||||
..gevtygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTIIALDIALEQLklenKVDIKGIVTFLRKQRKQ-MVQALCQYIFIHNAILE
||.||... |..|    .||.  .| .||.|| . .|| . ||.|.. |.||
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1061-1324 2.2e-72 238.8 In-house 35-295 (515) alignment 
Range on Protein: 1061-1324
Range on HMM: 35-295/515.0
ASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS
 ..|  | . .||||...  .| .|| |. |   ||| |.|| .|.... || |||.|||.. ..|||||.|..... ||.|.|.| |. |.|| .||| 
qtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPd

--SGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDttekERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEyGPIVVHCSAGVGRTGTIIAL
  .    .| | | .         ..| ..|  . |     ||| |||.| |||. || ..| .| ..... . ... .  |...|||||||||| .|..
kpgdsvkfGsikvelvsleactggikrkltvlkgdd....srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisi

DIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKL
|  . . |  . ||.  .|| .|..| ..||.  || ||..|.|||. . .| . .  | |    |
dsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1048-1324 2.9e-72 238.2 In-house 24-296 (315) alignment 
Range on Protein: 1048-1324
Range on HMM: 24-296/315.0
EFINSTSPDYACiASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLM
|| .   ||       | .. ...||||...  .|..|| |. |   |.| |||| .||...||| |||.|||.. . |||||||..... ||||.|.. 
efhdlpdPdiyr.qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkq

ESYKSKCHQYWPS--SGQCCYGDIAVRVDRNIELPHYTIRGFkvfNERDtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEYgPIVVHC
|. | || ||||   .    .| | | .         ..| .     |. .|. ||| ||..| |||. |. |.| .| ..... . |.|.|. ...|||
egdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl...vtrk.seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkef.sllvhc

SAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKL
|||||||| .|..|  ..|.| .. ||.  .|. ||..| ..||.  .| ||..|.|||. . .| ...  | |.   |
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdl
subfamily_PTPN3_pd Subfamily PTPN3 1047-1303 7.8e-72 236.5 In-house 21-273 (280) alignment 
Range on Protein: 1047-1303
Range on HMM: 21-273/280.0
FEFINSTSPDYACIASLAAHeyDQTKNRYRDVGAFDHTRVTLQEIPgvphSHYINANFIKG----YHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVM
|| .    |. |. |.  ..  . .||||||. ..|.|||.|.| .    . |||||...      .  . ||||||| ..|. |||.|||||.. .|||
feqlyrkkpglaisaarkpe..nlsknryrdilpydatrvklkese....tdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

LTNLMESYKSKCHQYWPSSG-QCCYGDIAVRVDRNIELPHYTIRGFKVFNERdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEyGPI
||.|.|. . |||||||... .. ||.. |.. .. |   | .| . . ...  |..||..||. |.|||| .|| .....|.|.. ....   .|  |.
lttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdke..tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgke.ePv

VVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
|||||||.|||| .|.|..||  .  ...| .  ||  .| ||. .||.  || |. .|||.
vvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1069-1302 1.1e-71 236.1 In-house 28-265 (274) alignment 
Range on Protein: 1069-1302
Range on HMM: 28-265/274.0
DQTKNRYRDVGAFDHTRVTL-QEIPGVPHSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC--
 ||||||...   ...||.| .| .  . |.|||||.||||.  .| |.|||||  .| .|||||......  |||||.| |. ..||..|.| . ..  
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

--CYGDIAVRVDRNIELPHYTIRGFKVFNERDttekERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEE--YGPIVVHCSAGVGRTGTIIALDI
   |||. ..|.  .|  .|..| . . .  .    ||.|  . ||.|||...| .|...||... .......|.   .|.|||||||.||||  || .|
serygdveikvekiverndysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAIL
|. ||. |..||. .||. || .|  |||.  || .||.|. 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1026-1304 1.6e-66 219.1 In-house 5-282 (290) alignment 
Range on Protein: 1026-1304
Range on HMM: 5-282/290.0
DEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAHeyDQTKNRYRDVGAFDHTRVTLQEIPGVPH--SHYINANFIKGYHDDKLYIATQGPKEE
|.| |.|..  .. .| |.. |. ..|.. ...    |.    ....||....   |  |.||..|.| .    .|||| .||||...| ||||||| ..
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltss..nkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn

TTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTtEKERTVLQFHYTAWPDRNVPAQASHVL
|  |||...|....  |||||| .|. | ||.||||.|..  || . ...  . .| .|..| ..| |.. . .....| |.. |.|..    .. . .|
tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtil

DFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILED
  .. ..  . |.  ..||||||..|||... .|....... | |  .|.  ..  .| |. ..||.  || .|.. .|. 
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1065-1303 2.8e-66 218.3 In-house 16-262 (270) alignment 
Range on Protein: 1065-1303
Range on HMM: 16-262/270.0
AHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSG-
..  ... |||.|.    .|||.|.|.   ... |||||...|... .| |||..||.. |. .||||.||... .|||.|.|.|  ..|| .|||..  
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

---QCCYGDIAVRVDRNIELPHYTIRGFKVFnerDTTEKERTVlQFHYTAWPDRNVPAQAS------HVLDFLRAINSANDKEEY-GPIVVHCSAGVGRT
   .. .|.|.|..  .     | ..  ..    .. |..| |  |.|..|||. || ..       ..|  |||.   ... .  .|..||||||||||
ekvkledgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||.||||||.. |. ..|||.  |.. |||.| ..||   || |...|..|
GtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1028-1332 3.7e-66 218.5 In-house 10-315 (325) alignment 
Range on Protein: 1028-1332
Range on HMM: 10-315/325.0
FQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAheyDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDD
. |||||   . |. |   |... |  .    .| . .   .. |||...| |.|..|| |.     |.| ||||.... . . . ..|.| |. .|..|
lvehvekkkaqdqdgfahefgllpsddgiakkvamkpe...nkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatind

FWRMVWEQRtVTIVMLTNLMESYKSKCHQYWPSS--GQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTteKERTVLQFHYTAWPDRNVPAQASHVLDF
.||.| . |  ..|...| ..  | .| .|||        .| . |..    |.  |  | ..| . ..   . |.| ||.. .|.|  |. . . .. .
lWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG..etrsvkqfqlqswddmGvqkrpatlisi

LRAINSANDK-----EEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDR
|. ..  ...     .  .||.|||||||||||. |.|  ||...  | .||| | |  |||.| .||..  |||.|..|. | .. |.| | .  |. .
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

CMKLQEPTLINE
   |||   . .
lsslqernpltq
subfamily_PTPN13_pd Subfamily PTPN13 1044-1303 6.3e-66 217.4 In-house 14-267 (273) alignment 
Range on Protein: 1044-1303
Range on HMM: 14-267/273.0
NEIFEFINSTSPDYACIAslAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGvphshYINANFIKGYHDD--KLYIATQGPKEETTDDFWRMVWEQRTVTIV
.| |. ..   |   |    . .. ...|||||.|  .|.|||.|..  |     ||||..||   ..    |||.|||  ||..|||.|||||..  |.
aeefkelrelkpldtcev..gkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MLTNLMESYKSKCHQYWPSSGQ---CCYGDIAVRVDRNIELPHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDkeEY
|.|.  |. | |||.|||.| .     .. . |.. .  .|  ...| ..| .    ... | | ......||| .||..| ..| |.. ... ..  . 
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds..esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..da

GPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||||||||||.||.||.|..|..|. .. ....|.| ||  ||.||. .||.  ||||...||||
gPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1069-1303 8.7e-65 213.2 In-house 3-237 (237) alignment 
Range on Protein: 1069-1303
Range on HMM: 3-237/237.0
DQTKNRYRDVGAFDHTRVTLQEIPGVphSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC-CY
.. |||| .. |.||.|| |.   .   | ||||...||.    | |||.||| | . ||||.|||...   ||||| |.|. . |||.||||. |  .|
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDIAVRVDRNIELPHYTIRGFKVFNeRDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRA-INSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQL
| ..| . .. |.  ||.| . ... | | .. | . |...|.|||| || |.. .| | .  || ..   | || ..|||||||||| .. .|  | | 
gvltvslkkkeefsdytvrslllsk.rltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
| .. |||   |  . ..|  ..|.  ||.|||..|||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1026-1311 1.2e-64 213.1 In-house 5-284 (287) alignment 
Range on Protein: 1026-1311
Range on HMM: 5-284/287.0
DEFQEHVEKLDKNKQEIFNEIFEFINS-TSPDYACIASLAAHeyDQTKNRYRDVGAFDHTRVTLQeipgVPHSHYINANFIKGYHDDKLYIATQGPKEET
..| | |.|  .. .| |.. |  ... |  .     ..| .  .. |||....   |  || |.      |  |||| ||.||...| .|....|  .|
ekfgefvakghakgnegfknqftvleqvtqredevthniasq..nkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnt

TDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEkERTVLQFHYTAWPDRN-VPAQASHVL
  .||.......  .||||....|. ...|.||||..   ..|. ....  .    .|..| ..| |.  ... ...| |...|.|...  |. ... .|
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagd.kqqvkqyqitnWdstgkvtepqtill

DFLRAINsANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTA
 . . .  .. |.  ..||||||..|||... .| ...... | |  .|.  ..   | |. ..||.  ||.|| ...|| .  ..| 
vieemyk.tqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1064-1317 3e-64 212.0 In-house 46-296 (297) alignment 
Range on Protein: 1064-1317
Range on HMM: 46-296/297.0
AAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDdkLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKsKCHQYWPSSGQ
| .  .  |.||...  .|  ||.|. .   | | |.|| |.||..    .|.|| |...| .|||.||..... |||||... |. | || .||. .| 
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

CCYGDIAVRVDRNIELPHYTIRGFKVfnERDTTEKERTVLQFHYTAWPDRNVPA--QASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIA
  .||..| .    |   .  | ..|  ... . ..| | |.... |||..|.   .|| .|...  ..   .... ||..|||.||||||| ....|  
ttfGdvsvvllsvsereGfikrelev..tkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv

LEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEF
. . | |..||| |.|. ||..| ..||.  || |...|.|| ..  ||.. .. |
vaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_PTPN1_pd Subfamily PTPN1 1038-1312 1.8e-63 209.0 In-house 3-280 (290) alignment 
Range on Protein: 1038-1312
Range on HMM: 3-280/290.0
NKQEIFNEIFEFINSTSPDYACIAslAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGvphsHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRT
.|.. ..||.. |.  . |. . .  | .. ....||||||  .||.|..|..       .||||....  . .. || ||||  .|.| ||.|||||..
dkkrlykeiyldirkeasdfptre..aklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqks

VTIVMLTNLMESYKSKCHQYWPSSGQ---CCYGDIAVRVD--RNIELPHYTIRGFKVFNerDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAI-NS
 ..||| ...|  . ||.||||.  .     . |. ..|.  .. .  .||.| ... |   .|.. |..|.||||.|||  ||   .  |.||  . .|
kavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen..lktqetreilhfhyttwpdfgvpespaaflkflfkvres

ANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENK---VDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDI--VYGDTAV
   ....|| |.|||||.||.||.. .|  | ... ...   ||||  .  |||.|  ..|.  |  | . |||| .  . ||..|
GslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1068-1303 5.8e-63 207.2 In-house 6-238 (239) alignment 
Range on Protein: 1068-1303
Range on HMM: 6-238/239.0
YDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGqCCY
 ...|||| .. ..||.|| |...   ||| ||||.... |    | ||||||  | .. |||||.|..| . ||||| |.| .| ||||||| |    |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.sky

GDIAVRVDRNIELPHYTIRGFKVfNERDTTEkERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSaNDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLK
 .. | . .   .  | || | . ..   || || | |.|.| |||. ||  |. || . | |   .      | |.||||||||||... .|  | | |
cnlrvtlrktevfadyiirtfvm.sqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqak

LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
 .. |||   |  .|..| .|||.  ||.||| |.||
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1068-1303 8.6e-63 206.7 In-house 7-239 (239) alignment 
Range on Protein: 1068-1303
Range on HMM: 7-239/239.0
YDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGqCCY
 ...|||| .. ..||.|| |...   ||| ||||.... |    | ||||||  | .. |||||.|..| . ||||| |.| .| ||||||| |    |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.sky

GDIAVRVDRNIELPHYTIRGFKVfNERDTTEkERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSaNDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLK
 .. | . .   .  | || | . ..   || || | |.|.| |||. ||  |. || . | |   .      | |.||||||||||... .|  | | |
cnlrvtlrktevfadyiirtfvm.sqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqak

LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
 .. |||   |  .|..| .|||.  ||.||| |.||
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_CG7180_pd Subfamily CG7180 1041-1307 1.4e-62 206.1 In-house 17-292 (296) alignment 
Range on Protein: 1041-1307
Range on HMM: 17-292/296.0
EIFNEIFEFINStSPDYACIASLAAHeyDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTI
  .. ... ..       | . | ..   . |||. .|  .|..|| |... |  .|.|||| .. ..  .| || |..||.|| |.|||.|... . ..
veyklelkltpr.leigdCagglrke..nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisav

VMLTNLMESYKsKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNE--------RDTTEKERTVLQFHYTAWPD-RNVPAQASHVLDFLRAINS
|.||. ..  | ....|||  ..  ||.| | . .. .... .|| ||.  .        .. . ..|.|..|..| |.   .||  .. .....| ...
vvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl

ANDKE----EYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVY
  .|     |.||.||..| |..|.|  .|.|..||... |..||. . |  ||..|.|.|.   .| .| . .|| .. 
wrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_PTPN14_pd Subfamily PTPN14 1024-1303 9e-62 203.7 In-house 8-294 (300) alignment 
Range on Protein: 1024-1303
Range on HMM: 8-294/300.0
GRDEFQEHVEKLDKnKQEIFNEiFEFINSTSPDYACiaSLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVpHSHYINANFIKGY--HDDKLYIATQGPK
 .|.  ...||  . . ..| | .| |   . |  .  | |. . .. |||..||  ....|| |.      .. ||||  ||      .. ||..||| 
tkdkrakilekkle.egkvfte.yeripkkredall..staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPl

EETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS----GQCCYGDIAVRVDRNIELPHYTIRGFKVfnERDTTEKERTVLQFHYTAWPDRNVPA
| |  |||.||||| .  |||||.  |. | |...|.|..     .  .|   |    . . . .. .|.|.  .   ...||||. . || |||..|| 
eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglkl..khlpskeertvwhlqytDWpdhgvPe

QASHVLDFLRAINSAND--------KEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
  .. |..|. ..|           ||.  |..||||||||||| .|  |. .. |. ....||| ... ||.||  .||.|.|| |.......
DvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1036-1313 1.7e-60 199.3 In-house 4-274 (283) alignment 
Range on Protein: 1036-1313
Range on HMM: 4-274/283.0
DKNKQEIFNEIFEFINStsPDYAciASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGvphsHYINANFIK---GYHDDKLYIATQGPKEETTDDFWRMV
 .|....| | .. ..   ||    | .|. . ...|||.... . |  || |.  .     .|||| ||     |..|| ||..|.| ..|  |||.||
rvnnnklfrevlkrlsv..pdld..adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmv

WEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTtEKERTVLQFHYTAWPDRNVPAQASHVLDFlRAINSA
.... ..|||||.|.|  . || ||||. |   ||. .| . ..     ..|. . . ..  . ...  .  . .  | . .  |    .. |   . | 
fdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssa.kstlllahyqvidWleygeqaiinslvkf.nkvisl

NDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVT
  ... ||||||||.|.|||.. ||.  ...... |  ||.  .|. .|.||  .||.| || ..|...||. . ||| ..
qteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1042-1325 5.9e-59 194.4 In-house 21-256 (392) alignment 
Range on Protein: 1042-1325
Range on HMM: 21-256/392.0
IFNEifEFINSTSPDYACiASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIV
.| |  || .  .||     . | .| .. ||||...  .| .|| |. |  .|.| |.|| .|.... .| |||.|||.  . |||||||..... ||.
lffe..efhdlpgpdiyp.qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttia

MLTNLMESYkskchqywpssgqccygdiavrvdrnielphytirgfkvfnerdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSanDKEEYG-P
|.|.| |                                                .. ||| |||.| |||..|| ..| .| |.. ...  |  .|  |
mvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevka..dfGqythp

IVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGDTAVTIDEFKDRCMKLQ
...|||||||||| .|..|  . . |    ||.  .|| .|..|  |||.  || ||. |.|||... .| . .  | |.  .|.
liihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1035-1303 6.7e-59 194.0 In-house 12-291 (301) alignment 
Range on Protein: 1035-1303
Range on HMM: 12-291/301.0
LDKNKqeiFNEIFEFINSTSPDYACIaslAAHEYDQTKNRYRDVGAFDHTRVTLQEIPG--VPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMV
  .||   |.| .. ....... . .     .| ... ||....  .|. |..|.. |   . . .||||..|.|| . | .||.||| ..|  ||||..
khsnk...feeqykelkegedksctv...glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrli

WEQRTVTIVMLTNLMESYKSKCHQYWPSSG--QCCYGDIAVRVDRNIELPHYTIRGFKVF-----N----ERDT----TEKERTVLQFHYTAWPDRNVPA
|....|.|||.||| |. ||||.||||.|   .  .| . | .  .  .| ..|| ..|      |    ||      . . ..|||.. | ||.  |  
wqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr

QASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
.   ||  .  .  .. | . ||.|||||..|.|.|. ....|.||| | |  ||. ...  .|...  .|. | ||..|...| .
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
subfamily_PTPRN_pd Subfamily PTPRN 1059-1305 4.3e-57 188.1 In-house 46-292 (297) alignment 
Range on Protein: 1059-1305
Range on HMM: 46-292/297.0
CIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHD-DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQY
. ...| .|   .|||...| ..||.||.|.|     .|.|||| .|         |||||||  .|  |||.||||| .| ||.||.| |.  ..|..|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPSSGQCCYGDIAVR-VDRNIELPHYTIRGFKVFNERdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKeEYGPIVVHCSAGVGRTGTII
||  |.  |.   |. |   |    | .| | . | .  |.. ||| |||. .||...|||.|  .|.| | .| .       |||||||.|.||||. |
wpdeGsevyhiyevhlvsehiwcddylvrsfylknlq..tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyi

ALDIALEQLK-LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDI
..|. |..|.   ...||   .  || ||...|..  |. |.  |. |..
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1046-1302 1e-56 186.9 In-house 15-274 (287) alignment 
Range on Protein: 1046-1302
Range on HMM: 15-274/287.0
IFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVpHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTN
 .. .   |   . .   | . ..  |||| ||  .|.||| | . .    | |||||.. .|.||. .||.|||   |  ||||.|.|.|. .....| 
evdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr

LMESYKSKCHQYWPSSGQCC--YGDIAVRVDRNIELPHYTIRGFKVFNeRDTtEKERTVLQFHYTAWPDRNVPAQ----ASHVLDFLRAINSANDKEEYG
 .|  . ||..|||   .     |   | .|..|  |.|..| ... .  .| .. | | |... .|||. ..      .  |||  . |. | | .| |
eveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlid.let.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG

PIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAIL
|.|||...|.||.|...|. . ...|.   .||.  .| .||..|. .|||  |. .. .|. 
PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPN23_pd Subfamily PTPN23 1031-1304 5.3e-56 184.6 In-house 5-279 (288) alignment 
Range on Protein: 1031-1304
Range on HMM: 5-279/288.0
HVEKLDKNKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQeipgVPHSHYINANFIKGYHDD-KLYIATQGPKEETTDDFW
....   . .  ... |. ....    |   |.|. .   .|||.||.  .||.||.|.      .  |||| |.|.       .||||.|...|  |||
elqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFW

RMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS-GQ-CCYGDIAVRVDRNIELPHYTIRGFKVFNERdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLR
.||.||.. .||||..  |  | |...|||.. |.   .||. | . .. |....  | .|.  ..  ... ..|   ..|.||.  |||  ...|.|| 
lmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld..adavksvshlqltsWpelGvPasPetllqfld

AINS---ANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKV-DIKGIVTFLRKQRKQMVQALCQYIFIHNAILED
...|   |. ..   |.||||||||||||..  .  |...|. .| . ||  .|  ||.||. |||   |. |  .|.|| 
evesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0051429 (Phosphotyrosine protein) phosphatases II 1094-1304 7.7e-54 178.4 In-house 1-224 (272) alignment 
Range on Protein: 1094-1304
Range on HMM: 1-224/272.0
VPHSHYINANFIKGYHD---DKLYIATQGPKEETTDDFWRMvWEQRTVTIVMLTNLMESYKSKCHQYWP------------SSGQCCYGDIAVRVDRNIE
.| |.||||....||.    ........|| . | .||||. .|..  |||.|....|  . ||..|||            |  .  ||.. |..   . 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LPHYTIRGFKVFNERDTTEKeRTVLQFHYTAWPDRNVPAQAshVLDFLRAINSandkeeYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVD------
|..|..| . . .. ...|  |.|...|||.|||..|| .|  .|..|.....       ||..||||||..||||..||.. |... ||  ||      
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--IKGIVTFLRKQRKQMVQALCQYIFIHNAILED
  . ..|  ||.|| ..||   ||.|...|.|| 
lyleeaveelraqrpgavqteeqylflyeallel
0041856 (Phosphotyrosine protein) phosphatases II 1070-1309 5.8e-51 168.0 In-house 2-175 (182) alignment 
Range on Protein: 1070-1309
Range on HMM: 2-175/182.0
QTKNRYRDVGAFDHTRvtlqeipgvpHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTnlmesykskCHQYWPssgqccygdi
..||||.|.  .||.|          ...|||||.. |.. .. .||||||  .|. ||.||..|..  |||.||         ...|||          
ldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

avrvdrnielphytirgfkvfnerdtTEKERTVLQFHYTAWPDRNVPAqASHVLDFLRAINSandkeEYGPIVVHCSAGVGRTGTIIALDIALEQlklen
                          .. ||...|..|. ||| .||   ...|||......     | ||..||||||||||||..|... ...     
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

KVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYGD
.|..  .| ..|..| .||. . ||.|.. |.|| . ...
gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1037-1303 2.8e-48 159.0 In-house 24-281 (290) alignment 
Range on Protein: 1037-1303
Range on HMM: 24-281/290.0
KNKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQEipGVPhSHYINANFIKGYHddKLYIATQGPKEETTDDFWRMVWEQR
|| .|.  | .| .    |      ..  .. . .||||.||   | ||| |..  | .   |. ||..|| .    .| |||. ..|. |.|||| ...
knvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd..Gyd.GdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqek

TVTIVMLTNLMESYKSKCHQYWPS-SGQC-CYGDIAVRVDRNIELPHYTIRGFKVFNERDtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANd
. .|||| .|.|  |.||.||.|  .|.   .|.|.|    . .    .|.      ..| . ||  .  ..  .|||. |.  .  .|  ||..  |. 
vaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkd.sGkehklkhlkikswpdksvalstlallrtlrilrkas.

keeyGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
    ||.|||||||.|||||..|....|. |    ..|. ..|  ||. | . ||   ||. . ...|.
....GpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
0036282 (Phosphotyrosine protein) phosphatases II 1097-1298 1.2e-46 154.0 In-house 2-163 (174) alignment 
Range on Protein: 1097-1298
Range on HMM: 2-163/174.0
SHYINANFIKGYHDDKLYIATQGPKEettddFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSsgqccygdiavrvdrnielphytirgfkvfnerDTT
|.||||.......  . .||.||| .     ||.|..|..  |.|||....|  . ||..|||.                                 . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

EKERTVLQFHYTAWPDRNVPAQAShVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKlENKVDIKGIVTFLRKQRKQMVQALCQYIF
  ||...|..|. |||..||  .  .|.|......|  . . ||..||||||||||||..|... | .|. |. ||.  .|  ||.|| .|||   ||.|
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IH
..
ly
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1035-1303 2.1e-46 153.3 In-house 11-275 (307) alignment 
Range on Protein: 1035-1303
Range on HMM: 11-275/307.0
LDKNKQEIFNEiFEFINSTSPDYACIaslAAHEYDQTKNRYRDVGAFDHTRVTLQeIPGVpHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWE
|||  |.. .| |. .   .|.   .    | . .. ||||.|| . |..|. .. ..|.  | || ||..    . | .|..|||.|.|  .|| |. .
ldkgvqalvde.frvlakktpegvtv...eafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiq

QRTVTIVMLTNLMESYKSKCHQYWPSS-GQ-CCYGDIAVRVDR-NIELPHYTI--RGFKVFN-ERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRA
..  ...|| ...|  | ||.||||   ||   .|. .  .   |.   . .      .| . . | ..| ||. .. .. |||| ||      ...| |
ekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea

INSANDkeeygPIVVHCSAGVGRTGTIIALDIALEQ-LKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
..  ..     |.||||||||||.|||.|. .  .. .. .|  |.| .|  ||.||.  .|.  ||...|  .||
vrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
0049772 (Phosphotyrosine protein) phosphatases II 1064-1303 8.7e-46 152.4 In-house 41-278 (314) alignment 
Range on Protein: 1064-1303
Range on HMM: 41-278/314.0
AAHEYDQTKNRYRDVGAFDhTRVTLqEIPGVPHSHYINANFIKGYhddKLYIATQGPKEETTDDF----------WRMV--WEQRTVTIVM---------
| ..  ..|||| |.  .| .|| |    .|  | ||||....|.   . .||||||.|.| .||          ||||  ..... .|||         
adlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTNLMESYkskchqywpssgqccygdiavrvdrnielPHYTIRGFKVFNERD--TTEKERTVLQFHYTAWPDRNVPaQASHVLDFLRA
            |..|.. .                             ...| . .. ..|.       ||........ .|| ..|   .....||..
lsrLdaAlgKtpllildgng.............................neptaadlellkeelydpelferlgikylripvpDgsap.lledfdeflef

INSAndkEEYGPIVVHCSAGVGRTGTIIALDIALEQLklenKVDIKGIVTFLRKQRK-----QMVQALCQYIFIHNAILE
|..|   .. ||..|||.||.||||| ..... . .|    .|... .. ..|..|       ... |.||.||..|.||
ieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1047-1303 2e-45 149.6 In-house 17-267 (281) alignment 
Range on Protein: 1047-1303
Range on HMM: 17-267/281.0
FEFINSTSPDYACIAslAAHEYDQTKNRYRDVGAFDHTRVTLQE-IPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTN
|  .    |   | .    .  .. |||| .. ..| .|| |.  .|    . || ||.|.     . || |||||.||  |||||.|.. | .|||| .
fsnlpgdppsdlctv..fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

LMESYKSKCHQYWPSSGQCCYGDIAVRVDRN---IELPHYTIRgFKVFNErdttEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANdkeeyGPIV
..|. . || .|.|   .||     . |. .   ..    | | ...  |     . | . .. .  ||| .||  .  .|  || | .        | |
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr.lnlsye....getrlithwlwkewpdwqvpessevmlkilrkirars.....tppv

VHCSAGVGRTGTIIALDIALEQLKLENK-VDIKGIVTFLRK-QRKQMVQALCQYIFIHNAILE
.||||||||.||..|..|||. ..      ||| ||. ||   |   ||.| ||..| . .|.
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1068-1303 1e-44 147.5 In-house 47-285 (305) alignment 
Range on Protein: 1068-1303
Range on HMM: 47-285/305.0
YDQTKNRYRDVGAFDHTRVTLqeIPGVPHsHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCY-
 .. ||||.||| .|. || |   .  || .|| ||..    . | .| || | |.|  ||| | ....  .| || ||.|    ||..|..|  .    
qeagknrykdvgcldnnrvkl..egpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

-----GDIAVRVDRNIELPHYTIRGFKVF----NERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRainsaNDKEEYGPIVVHCSAGVGRTGTIIA
       |.|...   .|   .    ||         . || | | ..|.  |||| |||    .|..|      . .   ||||||||||.||||... 
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle.....karpskgpivvhcsagigrtgsvvm

LDIALEQLKLENKVD-IKGIVTFLRKQRKQMVQALCQYIFIHNAILE
|.  |.||   ....  . |.  .|.||.. .|.  ||.|.|. ||.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
0046846 (Phosphotyrosine protein) phosphatases II 1088-1302 2.6e-44 146.4 In-house 3-170 (176) alignment 
Range on Protein: 1088-1302
Range on HMM: 3-170/176.0
LQEIPGVPHSHYINANFIKGYhddkLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCCYgdiavrvdrnielphytirgf
|...   ....|||||.| |.    ..|||||| ..|. ||..|..|..  ..|.||...|  . ||..|||   .  .                     
lrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kvfnerdttekertvlQFHYTAWPDRNVPAQaSHVLDFLRAINSANDKEeyGPIVVHCSAGVGRTGTIIALDialeQLKLENKVDIKGIVTFLRKQRK-Q
                |.... ||| .||   ...|..|..|..| ..   ||..||||||.|||||..|..     |.||. ...  .. ..|.||  .
................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplg

MVQALCQYIFIHNAIL
.||  .|| |.. ..|
avqtpeQyrflyefel
0043147 (Phosphotyrosine protein) phosphatases II 1095-1298 1.2e-43 144.2 In-house 3-154 (172) alignment 
Range on Protein: 1095-1298
Range on HMM: 3-154/172.0
PHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLmesykskchqywpssgqccygdiavrvdrnielphytirgfkvfnERD
..|.||||.....|.  . .||||||  .|..|||||..|.   .||.||.|                                             . |
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

TTEKERTVLQFHYTAWPDRNVPaQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALeqlkleNKVDIKGIVTFLRKQRKQMVQALCQY
..  ||...|..|. ||| .||  ....|.||. |...  ... ||..||||||||||||..|... |       ....  .| ..|..| ..||   ||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

IFIH
.|..
rfly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1035-1303 9.7e-43 140.9 In-house 19-287 (305) alignment 
Range on Protein: 1035-1303
Range on HMM: 19-287/305.0
LDKNKQEIFNEIFEFINSTSPDYACIASLA--AHEYDQTKNRYRDVGAFDHTRVTLQEIPgvpHSHYINANFIKG-YHDDKLYIATQGPKEETTDDFWRM
||   . . .|. .. . | || . .|  |  . . ..|||||.|| . |.. | |.. .    |.|| ||..      .| .|..||| ..| |.|| |
ldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwm

VWEQRTVTIVMLTNLMESYKSKCHQYWPSSG-QC--CYGDIA-VRVDRNIELPHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLR
| ...   |||| . .|  | || |||| .  .     . |    |  .  .   .     ..|   . ... .| ....| |||| ||      |..| 
viqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslells

AINSANdkeeyGPIVVHCSAGVGRTGTIIALDIALEQLKlENK--VDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
||  ..      |||||||||.||||||.|..  ||..  |||    .  .|  || ||   .|.  ||.|||  .|.
airgsk.....vpivvhcsagigrtgtivaieyilekia.enkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0049260 (Phosphotyrosine protein) phosphatases II 1104-1298 7.6e-42 137.9 In-house 1-143 (152) alignment 
Range on Protein: 1104-1298
Range on HMM: 1-143/152.0
FIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWpssgqccygdiavrvdrnielphytirgfkvfnerdttekertvl
||.||.  . .|||||| ..|..|||||..|.   ||||||.|.| .| ||.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QFHYTAWPDRNVPAQASHVLDFLRAINSAnDKEEYGPIVVHCSAGVGRTGTIIALDIALeqlkleNKVDIKGIVTFLRKQRKQMVQALCQYIFIH
|.... ||| .||  . ..|..|..|. .  ... ||..||||||||||||..|... |      ..|... .| ..|..|...|.   |..|..
qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1041-1303 5.6e-41 135.3 In-house 6-257 (267) alignment 
Range on Protein: 1041-1303
Range on HMM: 6-257/267.0
EIFNEIFEFINSTSPDYACIASLAAHEyDQTKNRYRDVGAFDHTRVTLQEIPGVphshYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTI
  ... || |.  |.. . |.   |..  | .||. |.  .|.||| |..        |||| ...||.  . .|.||.| . |  ||. .. .|.  .|
ceiekefelikkisdtsstisqsiaek.nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLtnlMESYKSKCHQYWPSS-GQC-CYGDIAVRVDRNIELPHYTIRGFKVfneRDTTEKERTVLQFHYTAWpdrNVPAQASHVLDFLRAINSANDKEEY
|.|   . ... . ...||   ||.  | |..|    . |   | |  ...   .   |  . |  ..|  |   |. ..    |  | .| . |. |. 
vll...tkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfknesahnvtlyyykkw...nintnnkpylkplfgilaknqleng

G-PIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILE
. |.||.||.||||.|| . .|  ||..| |. .||   .  .|.||  .|... .||.||. . |
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1065-1302 4.5e-39 128.8 In-house 48-287 (310) alignment 
Range on Protein: 1065-1302
Range on HMM: 48-287/310.0
AHEYDQTKNRYRDVGAFDHTRVTLQeIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQC
|..    |||| ||   | .|| |. |    .  || ||..|  .  . .| .||| . |  |||||....|. .|..| . .|  . ||  |||| |  
aykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt

-CYGDIAVRV----DRNIELPHYTIR---GFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFlRAINsandKEEYGPIVVHCSAGVGRTGTII
  || | |        ..|.   ..         .|. .  ||  |   ..  |||| || .  | .   | .     .  .|| |||||||..|.....
etygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq.rlla....qvrhgpcvvhcsagkdrlyvvv

ALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAIL
||......|.  .|||.. ..| |.|.| . .|.  ||..|.   .
alklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
0044763 (Phosphotyrosine protein) phosphatases II 1081-1300 7.2e-39 128.6 In-house 2-166 (178) alignment 
Range on Protein: 1081-1300
Range on HMM: 2-166/178.0
FDHTRVTLQEIPGVPHSHYINANFIKGYhddkLYIATQGPkeettDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQccygdiavrvdrnielp
.|.||| |....|.. | ||||..| ..    ||.....|      |......|.   .||.||. .| .. ||..|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

hytirgfkvfnerdttekertvLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEyGPIVVHCSAGVGRTGTIIALDIALEQlklenKVDIKGIVTFL
                      .|.... .|| .||   .|.|.|...|..| |... ||..|||||||||.||..|... ...     ....  .. ..
......................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielv

RKQRKqMVQALCQYIFIHNA
|..|  .|.   |. ...  
rerRp.ivpnpgqlrqLyef
0051082 (Phosphotyrosine protein) phosphatases II 1095-1302 5.2e-38 125.3 In-house 1-150 (151) alignment 
Range on Protein: 1095-1302
Range on HMM: 1-150/151.0
PHSHYINANFIKGYhddklYIATQGPkeetTDDFWRMVWEQRTVTIVMLTNLMESYksKCHQYWPSSGqccygdiavrvdrnielphytirgfkvfnerd
|.|.|||.... |.     .....||    ..||.....|.   |||.|....| .  .|..|.|. |                                
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

ttekeRTVLQFHYTAWPDRNVPAQASHVLDFLRAINSandkEEYGPIVVHCSAGVGRTGTIIALDIALEQlklenkVDIKGIVTFLRKQRKQMVQALCQY
     ..||..... ||| ..|     ||.||.....     . ||..||||||.|||||..||.. |..      |..  .. ..|..|  .||   |.
.....ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

IFIHNAIL
.|.. |.|
lfqlfall
subfamily_ptpA1_pd Subfamily ptpA1 1062-1265 2.3e-36 120.5 In-house 40-256 (418) alignment 
Range on Protein: 1062-1265
Range on HMM: 40-256/418.0
SLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHdDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS
|   .... .|||| ..   .|||| |..|     | |||||.| | .  | .|.||||  .|  ||||||||.|   ||||.   |  . || .|||  
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

-----------GQCCYGDIAVRVDRNIELPHytiRGFKVFNERDTTEKE-RTVLQFHYTAWPDRNVPAQASHVLDFLRAINSAND-----KEEYGPIVVH
           |.  .|  .| .   |. |    |     | | | | | | . |..|  |||.|.| ..  . ..|..|   ..      .   ||.||
iggeqfsiygngnevfgtysvelveviqdpe...reiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivh

CSAGVGRTGTIIALDIALEQL
||||||||||. .  | ...|
csagvgrtgtfctavimmkkl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1053-1307 2.7e-36 120.1 In-house 27-273 (288) alignment 
Range on Protein: 1053-1307
Range on HMM: 27-273/288.0
TSPDYACIASLAAHEYDQTKNRYRDVGAFDHTRVTLQeipgVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKS
 ||. | | .  ..  . |..||...   | ||| |.         ||.|| .   . ..  | .| | . | . .|.|. |.    ||||..|.|  | 
dspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGke

KCHQYWPSS-GQC-CYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEKErTVLQFHYTAWPDRNVPAQASHVLDFLRAInsandKEEYGPIVVHCSAGVG
|  .|.||  |.   .| .   | .. .  . ...   . ... . ||   | . |.  |.|  || .    | .|  .     |.   |||||.|||||
ksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvG

RTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVY
||||.|   ||||.|.|.. . |. ... ||..|.. .|.  ||...|  .||....
rtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
PTPc_DSPc_SM00012 1201-1303 4.8e-36 118.5 In-house 1-105 (105) alignment 
Range on Protein: 1201-1303
Range on HMM: 1-105/105.0
TVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEE-YGPIVVHCSAGVGRTGTIIALDIALEQLKLE-NKVDIKGIVTFLRKQRKQMVQALCQYIFIH
|| ..|||.||| .|| .....|..|||... . |.|  .|.|||||||||||||..||||.|.||. | ..|||. ||  ||||| .||| . ||.|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

NAILE
.|.||
ralle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1063-1306 3e-33 110.0 In-house 29-271 (285) alignment 
Range on Protein: 1063-1306
Range on HMM: 29-271/285.0
LAAHEYDQTKNRYRDVGAFDHTRVTLQEIpgvpHSHYINANFIKGY-HDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS
 .|.| .   ||| || . . ||| |..        || |....   .|.  ||.||||  ||  |||.|.....   ..||  |.|    ||  |.|  
ytayeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

-GQ-CCYGDIAVRVD--RNIELPHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEygPIVVHCSAGVGRTGTIIA
 |.   .|   . .   ..  .    .  . | |  |.. .   . . .   |||.  | .|  .... . ..  | ||.  ||.|||||||||| |.. 
lgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek..picvhcsagvgrtatfvg

LDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIV
.| |  ..  . ....  ||  .|  | | ||.  |..|..  ..| ..
idyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_egg_pd Subfamily egg 1049-1308 4.6e-32 105.9 In-house 22-276 (307) alignment 
Range on Protein: 1049-1308
Range on HMM: 22-276/307.0
FINSTSPDYAcIAsLAAHEYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLME
 .. .. . . .   || .  ..| | . |   | .||.|.   |     .| || .||      .| .| |  .| |||||||....   |||||   |
vleesvdeis.lt.taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrke

SykSKCHQYWPSSGQC--C--YGDIA---VRVDRNIElPHYTIRGFKVFNERdttEKERTVLqfHYTaWpDRNVPAQASHVLDFLRAINSANDkeeygPI
|   .|. ||| . .       | .    ..||.. . | ...  .|.       ..|| .   |.  . | |  ..    |  || .  .       |.
s..erceyywpkaesdslvtvpGslrienlkvdskad.plfrvtklklvGgd...deerfle..hwq.g.dvnnssdvysplrvlrklrnlsk.....pv

VVHCSAGVGRTGTIIALDIALEQLKL--ENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAIL---EDIVYG
||..  || ...|..|..||| .|      |  ..  | |||..|.  |..  .|.|..  .|    |..  
vvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigs
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1036-1296 2e-31 103.9 In-house 18-272 (301) alignment 
Range on Protein: 1036-1296
Range on HMM: 18-272/301.0
DKNKQEIFNEIFEFINSTSPDYACIASLAAHeYDQTKNRYRDVGAFDHTRVTL-QEIPGVPhshyINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWE
|..  ...|  .| .| |. |   |    |.   . |.||  |    .| | . ..   ||    | ||.|.   . . .|||||| ..|..||| |.  
ddktakfynttienvnvttidkdhitesyay.lpkdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvq

QRTVTIVMLTNLMESYKSKCHQYWPSSG--QCCYGDIAVRVDRN--IELPHYTIRGFKVfneRDTTEK--ERTVLQFHYTAWPDRNVPAQASHVLDFLRA
    .||||.. .|  ..||..| |..   .   |   ...  .  |   . . | ..|   .|.|.|   |||. . |. |.||.||    .. |..  
ydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlev...edstgkfatrtvthyqysewtdrgvPkshaelfdlmel

InsandKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIF
.     |.   |||||||||.||. . |. ..   ... .......  .  ||..| . ||   |  .
v.....kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_CG42327_pd Subfamily CG42327 1070-1231 2.1e-31 103.7 In-house 29-192 (319) alignment 
Range on Protein: 1070-1231
Range on HMM: 29-192/319.0
QTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYHDDK-LYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSS----GQC
. |.|. .|  . .|||.||.|.  ....|..|....||.| .  |||.| . |... ||||.||||.. .|| ||.| |    .| .|.|..    .. 
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

CYGDIAVRVDRNIELPHYTIRGFKVfnERDTTEKERTVLQFHYtAWPDRNVPAQASHVLDFLRAINS
 |||| | .  .    .| |  . .   |   |. | .  . |  |.. .|||. . ..  |  ..|
lyGdilvtlkgrevkdryaistlll..krvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1198-1328 3e-31 103.2 In-house 87-217 (440) alignment 
Range on Protein: 1198-1328
Range on HMM: 87-217/440.0
KERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFI
. ||. |.|| .|||. ||  |. || ... .| ...|   ||..||||||.|||| |||.|  | . |  ...||  ..  .|..| ||||.  || |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HNAILEDIVYGDTAVTIDEFKDRCMKLQEPT
|.|.|| .. ||| .  |.  .|  ..| | 
heavlegllcgdtliledditerveqiqwpn
0047943 (Phosphotyrosine protein) phosphatases II 1322-1566 4e-31 103.9 In-house 6-271 (273) alignment 
Range on Protein: 1322-1566
Range on HMM: 6-271/273.0
MKLQEPTLINEEFNKIGSVKPPAQ------------------ACPGPSIVPFETDKDSKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHI
.||  .||. |||... |.||.                     .   | |  . ....     |.|||.... ||    |...| | |||.. .. ...|
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

INLSPAD----ITTYSYIPPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESCHRG
. | . .    .. . | |...|.  |..|..|| . . . . .. .| . . | ... ... ....| .    .. |  . ...||. .    |.....
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

nHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEY
 .|...|  .  |  | |..| ..|.. .||. .|.|.  ..   | || . ....| ..|..||||
.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0050432 (Phosphotyrosine protein) phosphatases II 1310-1571 1.3e-30 102.2 In-house 24-303 (308) alignment 
Range on Protein: 1310-1571
Range on HMM: 24-303/308.0
TAVTIDEFKDRCMKLQEPTLINEEFNKIGSVKPPAQ------------------ACPGPSIVPFeTDKDSKFTSYYLDGY--WTPNLFIKSPSPTKETEE
. ......  ...|. ...|..|||... ||||. .                   .   | |    ....     | |||  . |. ||   .|...| |
lklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntve

LFWRLIVQNECTHIINLSPAD----ITTYSYIPPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKF
 |||.. ......|. |   .    .. . | |...|.  |..|..|| . . . . .. .| . . | .|. ..... ..|      .. | .. ...|
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldf

IQGCLVEAeschrGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYSDKLL
.. .         ...||..|     |  | |..| ..|.. .||. .|...  ..   | || . ... | ..|..||||  ..|
lelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1054-1309 3.4e-30 99.8 In-house 32-279 (312) alignment 
Range on Protein: 1054-1309
Range on HMM: 32-279/312.0
SPDYACIASLAAHEydqtKNRYRDVGAFDHTRVTLQeipGvPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSK
 .|  | | |  ..     ||| ..  .|  | ||    |     || |||.|     . ...|||| |.|.  ||...    ...|..|. ..|    |
vsdsectaflkfkd....lnrypniqcwdrgrftla...g.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsek

CHQYWPS-SGQCCYGDIAVRVDRNI--EL-----PHYTIRGFKVFNErdTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINsaNDKEeygPIVVHC
| .|     |     |  |  .     |.      . | | .||     .| .|  . .. ...|||  .|      | .| |..  .||    |.. ||
cakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvk..atgqesklnhyqwaswpdhgmpdscdtalrllsavk..kdkk...pviahc

SAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEdIVYGD
|||||||||.. ..  .  |.   | ..| .  .|||.| . |... ||..   ..|| ..|  
sagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle.flysk
0040438 (Phosphotyrosine protein) phosphatases II 1367-1583 5.7e-30 100.1 In-house 78-292 (317) alignment 
Range on Protein: 1367-1583
Range on HMM: 78-292/317.0
YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKL
| ||.. .. ||   .|...| | |||.. .. .|.|..| . .    .. . | |    .  |..|..|| .   . . |.  | . . . .|| ....
yvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl...getltygdftvtllseeelagitlrtlevedlgdsesrtv

KYIQYQEMLLKQCFPRADKFIKFIQGCLVEAEschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDC
. ..|       . |  | ...|.. .    |   ....|.|.|  .  |  | |... ..|.. .||. .|. .  ..   |.|| . ....| ..||.
thfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda

LLEYSDKLLKEESLPPIYENI
||||  . |. |.... .  .
lleylkrkltlepaselklkl
0036941 (Phosphotyrosine protein) phosphatases II 1326-1567 3.8e-29 97.3 In-house 11-277 (297) alignment 
Range on Protein: 1326-1567
Range on HMM: 11-277/297.0
EPTLINEEFNKIGSVKPPAQ------------------ACPGPSIVPFETDKDSKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLS
 ..|. .|| .. .....                     .   . | .. .... .   |.|||. .. ||    |...| | |||.. .. .|.|..|.
flalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

PADI----TTYSYIPPDVGDrQLKFGPLTVSVGRKQF--NTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAeSCHRGNH
. .     . ..| |...|.  |..|..|| . . .   .... .| . . . ... ........|       . . .. ...||. ..    .  ....
elvelgrekcaqywpleege.sltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl.kllpsgg

PILIHDDGSNGPVGIFATLAYCLQRAK---KERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYS
|.|.|  .  |  | |... ..||. .   ||. .|.|.  ..   |.|| . .|..| ..|..|||. 
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 1351-1566 6.6e-29 96.7 In-house 26-245 (249) alignment 
Range on Protein: 1351-1566
Range on HMM: 26-245/249.0
SIVPFETDKDSKFTSY----YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNT
| |  .  ..   ..|    |.|||. .. ||    |..|| | |||.. .. .|.|..|.. .    .. . | |.   .  |..| .|| . . . . 
srvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...ggsleygdftvtllsvevkd

GFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESChRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHH
.. .| . . | .|..... . |||  .   .. |  . ...||. ..   |.. . ..|.|.|  .  |  |.|... ..|.. .||. .||..  .. 
dytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkll

YLQCPGLIVNLQFYAYCYDCLLEY
  |.|| . |...| ..|..|||.
rsqRpgavqnpeqyrflyeallel
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1069-1226 1.4e-28 94.6 In-house 33-190 (297) alignment 
Range on Protein: 1069-1226
Range on HMM: 33-190/297.0
DQTKNRYRDVGAFDHTRVTLQEipGVPHSHYINANFIKGYH--DDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQCC-
   ||||||. |.| ||| |.   ... . ||||...   .   |  || .||| ..| ||||..|.||   .|||...| |  ..||  ||||. |   
slrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

-YGDIAVRVDRN--IELPHYTIRGFKVFNErdttEKERTVLQFHYTAWPDRNVPAQASHVLDFL
  ||. |    .   |  .  .  ....      ...| |    . .|||  ||..   .  | 
kagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfq
0051299 (Phosphotyrosine protein) phosphatases II 1310-1566 1.5e-28 95.5 In-house 3-285 (288) alignment 
Range on Protein: 1310-1566
Range on HMM: 3-285/288.0
TAVTIDEFKDRCMK--LQEPTLINEEFNKIGSVKPPAQ------------------ACPGPSIVPFETDKDSKFTSY----YLDGYWTPNLFIKSPSPTK
|.. ..|. ....|  .  .|.. |||... |..|. .                   .   | | . . ... ...|    |.|||.... ||    |..
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

ETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNE----EDSSTLKLKYIQYQEMLLKQCFP
.| | |||.. ......|. | . .    .. . | |.   .  |..|..||   . . . .. .| . . |      |. ... . ..|      .. .
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

RADKFIKFIQGCLVEAEschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEY
 .. ...|.. .    .    |..|...|     |  | |..| ..|.. .||. .|.|.  ..   | ||.. ... | ..|..||||
spellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0043336 (Phosphotyrosine protein) phosphatases II 1347-1566 2.2e-28 95.0 In-house 56-276 (278) alignment 
Range on Protein: 1347-1566
Range on HMM: 56-276/278.0
CPGPSIVPFETDKDSKFTSYY----LDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPpdvgDRQLKFGPLTVSVGRK
.   | | .. ..    ..|.    .|||. |. || .  |..||.| |||.. .. .|.|..| . .    .. . | |    .  |..|..|| . . 
pydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp....ggsltygdftvtllke

QFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLlKQCFP-RADKFIKFIQGCLVEAEschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQ
. . .. .|.. . |  |. ...   ..|  .   ...|   . ...|..  .   |     |.|.|.|  .  |  | |..| ..|....||. .||..
ehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdlee

SANHHYLQCPGLIVNLQFYAYCYDCLLEY
  ..   |.|| . ....| ..|..||||
avkelreqRpgavqtpsqyrflyealley
0039614 (Phosphotyrosine protein) phosphatases II 1311-1569 2.3e-28 94.9 In-house 15-291 (297) alignment 
Range on Protein: 1311-1569
Range on HMM: 15-291/297.0
AVTIDEFKDRCMKLQEPTLINEEFNKIGSVKPPAQACPGP----------------SIVPFETDKDSKFTS-----YYLDGYWT-PNLFIKSPSPTKETE
 ... ..  ...|. ..||. .|| .. |.||.   .  |                | | . . ... . |      |.|||.  .. || .  |..|| 
plsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

ELFWRLIVQNECTHIINLSPADIT---TYSYIPPDVGdrqlKFGPLTVSVGRKQFNTGFSTRDISIFNeeDSSTLKLKYIQYQEMLLKQCFPRADKFIKF
| |||.. .. .|.|..| . .      ..| |...|    ..|..|| . . . . |. .| ... |  .. ..... .||  .   .. | .. ...|
edFwrmvweqgvtvivmLtklvelgrkcaqywpeegg....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllef

IQGCLVEAESChRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYSDK
.. .    ... ....|.|.|  .  |  | |... ..|.. .||. .|.|.  ..   |.|| . ....| ..||.|||.  .
lelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0046845 (Phosphotyrosine protein) phosphatases II 1365-1570 6.3e-28 93.4 In-house 62-277 (284) alignment 
Range on Protein: 1365-1570
Range on HMM: 62-277/284.0
SYYLDGY-----WTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPDvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEE
  |.|||     .... ||    |...| | |||.. ......|. | . .    .  . | |..  .  |..|..|| . ... . .. .| ... |..
AsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlg

-DSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAEScHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKER---IIDLLQSANHHYLQCPGLIV
 .. ........| .    .. | .. ...|.. .    |. . |..||..|. .  |  | |..| ..|.. .||.    .|.|.  ..   | || . 
ytgesrtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq

NLQFYAYCYDCLLEYSDKL
.|. | ..|..||||  ..
tleqyrfvyealleylklk
0045450 (Phosphotyrosine protein) phosphatases II 1323-1566 1.6e-27 92.5 In-house 22-303 (307) alignment 
Range on Protein: 1323-1566
Range on HMM: 22-303/307.0
KLQEPTLINEEFNKIGSVKP--------------------PAQACPGPSIVPFETDKDS-------------KFTSYYLDGYWTPNLFIKSPSPTKETEE
.|  .|.. .||.|. ||..                    .   .   . | . . ..|              .  ..||||. .. ||   .|..|| |
lldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetve

LFWRLIVQNECTHIINLSPAD----ITTYSYIPPDvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNE-EDSSTLKLKYIQYQEMLLKQCFPRADKFIK
 |||.. .. .|.|..|.. .    .  . | | .  . .| .|..|| . ...   |.  | . . .  ... ........| .    .. |  . ...
dFwrmlweqgvtvivmltelvelgrekcaqywPde..geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelld

FIQGCLVEAESChRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERI---IDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEY
||. ..   |.. ....|.|.|  .  |  | |... ..|.. .|| .   .|||.  ..   |.|| . |...| ..|..|||.
fieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0048076 (Phosphotyrosine protein) phosphatases II 1189-1301 2.3e-27 90.8 In-house 36-139 (145) alignment 
Range on Protein: 1189-1301
Range on HMM: 36-139/145.0
VfnERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEeyGPIVVHCSAGVGRTGTIIALDIALEqlkleNKVDIKGIVTFLRKQRKQMV
.   ....  ||...|..|. |||..||  ....|.||..|..| ...  ||..||||||||||||..|... |.     ..|..  .. ..|.|| ..|
l..tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgav

QALCQYIFIHNAI
.   |..|.. ..
pnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 1189-1299 4.3e-27 90.0 In-house 36-139 (144) alignment 
Range on Protein: 1189-1299
Range on HMM: 36-139/144.0
VFNERDTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEeyGPIVVHCSAGVGRTGTIIALDIALeqlklENKVDIKGIVTFLRKQRKQMV
. .|.. .. ||...|.... |||..||  ....|.||..|..| ...  ||..||||||||||||..|... .     ....... .. ..|..| ..|
lteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgav

QALCQYIFIHN
.   |..|...
pnpgqlrfLle
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1111-1298 2e-26 87.4 In-house 4-197 (199) alignment 
Range on Protein: 1111-1298
Range on HMM: 4-197/199.0
DKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS--SGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEKERTVLQFHYT
.. ||||| |  ||  |||.||||  .  |||. .     ..    |||.  ||   || ..| .      | |||  . . |.  .    | . .. .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDRNVPAQASHVlDFL---RAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKL--ENKVDIKGIVTFLRKQRKQMVQALCQYIFIH
.| ..  |  |  |  |.   | .    ..|   |..|||| | | || ..|||| .   .      ||.  .   ||. |  .. .| .| ||.
swkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1112-1298 2.2e-26 87.3 In-house 4-196 (198) alignment 
Range on Protein: 1112-1298
Range on HMM: 4-196/198.0
KLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS--SGQCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTTEKERTVLQFHYTA
. ||||| |  ||  |||.||||  .  |||. .     ..    |||.  ||   || ..| .      | |||  . . |.  .    | . .. .|.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDRNVPAQASHVlDFL---RAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKL--ENKVDIKGIVTFLRKQRKQMVQALCQYIFIH
| ..  |  |  |  |.   | .    ..|   |..|||| | | || ..|||| .   .      ||.  .   ||. |  .. .| .| ||.
wkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
0042113 (Phosphotyrosine protein) phosphatases II 1351-1566 2.7e-26 87.9 In-house 24-242 (245) alignment 
Range on Protein: 1351-1566
Range on HMM: 24-242/245.0
SIVPFETDKDSKFTSYY----LDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNT
. | .  |. . ...|.     |||. .. || .  |..|| | |||.. .. .|.|..|.. .    .. . | |.   .  |..| .|| . . . . 
trvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...gesltygdftvtllseehld

GFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKF---IQGCLVEaeschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSA
.. .| ... |. |. ...   ..|  .   .. .  . ...|   .. .| |      .|.|.|.|  .  |  | |... ..|....||. ..| .  
dytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeav

NHHYLQCPGLIVNLQFYAYCYDCLLEY
 .   |.|| . ....| ..|..|||.
kelrsqRpgavqtpsqyrflyeallel
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1118-1301 3.9e-23 76.3 In-house 97-284 (302) alignment 
Range on Protein: 1118-1301
Range on HMM: 97-284/302.0
QGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS--SGQCCYGDIAVR-VDRNIELPHYTI-RGFKVF-----NERDTTEKERTVLQFHYT
  || .|.. .| .. . ..  .| |....|. . || .|.     |.  .|  .|. |. . .| ..|  ..||..     ||. ......||  ....
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPDRNVPAQASHVLDFLRAINSANDKeeygpIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAI
||||   |..| . || |.  .|   .     ..||||||||||||..|.   ..  . ..  |.  ||. .|. |   ||   | |..   .
awpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
Y_phosphatase Protein-tyrosine phosphatase 1365-1565 9.6e-23 76.2 Pfam-A 32-235 (235) alignment 
Range on Protein: 1365-1565
Range on HMM: 32-235/235.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADI----TTYSYIPPDVGDrQLKFGPLTVSVG--RKQFNTGFSTRDISIFNEEDSS
  |..||.... || .  |.|.| | |||...|.... |. |   .     ..  | | . .. .|..| ..| .    |. .... .|.... .....|
AnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.sltygdikvelkekekedekeytlrklelkkkkees

-TLKLKYIQYQEMLlKQCFP-RADKFIKFIQGCLVEAescHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFY
 . ..| ..|..   ... |  .......|. .  .    .  ..|...|     |  |.|..| ..|.....|. .|.||  ..   | ||.. .|. |
ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY

AYCYDCLLE
...|...||
iflykaile
Y_phosphatase Protein-tyrosine phosphatase 1365-1565 9.6e-23 76.2 In-house 32-235 (235) alignment 
Range on Protein: 1365-1565
Range on HMM: 32-235/235.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADI----TTYSYIPPDVGDrQLKFGPLTVSVG--RKQFNTGFSTRDISIFNEEDSS
  |..||.... || .  |.|.| | |||...|.... |. |   .     ..  | | . .. .|..| ..| .    |. .... .|.... .....|
AnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.sltygdikvelkekekedekeytlrklelkkkkees

-TLKLKYIQYQEMLlKQCFP-RADKFIKFIQGCLVEAescHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFY
 . ..| ..|..   ... |  .......|. .  .    .  ..|...|     |  |.|..| ..|.....|. .|.||  ..   | ||.. .|. |
ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY

AYCYDCLLE
...|...||
iflykaile
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1068-1321 1.5e-22 74.4 In-house 50-298 (302) alignment 
Range on Protein: 1068-1321
Range on HMM: 50-298/302.0
YDQTKNRYRDVGAFDHTRVTLQEIPgvphSHYINANFIKGYHDDKLYIATQGPKEETT---DDFWRMVWEQRTVTIVMLTNLMESYKsKCHQYWP-SSG-
 .  ||.  || . |...| |.. |     .|.||  ..  .  .  | .| || ...   ..|||||.... |..|.|    |  |   ....|  || 
knlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

QCCYGDIAVRVDRnIELPHYTIRGF--KVFNErDTTEKERTVLQfHYTAWPDRNVPAQASHVLDFLRAInSANDKEEYGPIVVHCSAGVGRTGTIIALDI
   ||.. | . . .|  . .   .   |. | . ..   . .. . | |.. .|| . ...      .  |.. .   ..|.    |.|| |....| .
ykeygkmfvNnrk.VekaeeektryviEvlPe.gcsnsvlanvy.vltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlav

ALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILediVYGDTAVTIDEFKDRC
|.|.|. .... || ||. .|.|| ..|..|.||.... |.|   .|. . || .| |.. 
aveklqkgkepnikeivksiRsqRpravdslkQyvslyiall...lyikkkvtkpeekkkk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1073-1324 6.3e-22 73.0 In-house 23-269 (290) alignment 
Range on Protein: 1073-1324
Range on HMM: 23-269/290.0
NRYrDVGAFDHTRVTLQEIPGVPHSHYINANFIKgYHDDKLYIATQGPKEET-------TDDFWRMVWEQRTVTIVMLTNLMESYKS----KCHQYWPSS
.|. .|  . .||| |..      . || ||... . ..   |.|| |.|..         .|| |. . .   .||| . .|  .      | .| | |
qRl.evpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

G--QCCYGDIAVRVDRNIELPHYTIRGFKVFNErdtTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINsandkEEYGPIVVHCSAGVGRTGTIIALD
   .  .... |.    ..     .|   |  .    |.| ||    .  | ..||. .   .|. .. ..      .  |..|||  |. |  .. |..
vgeelkfkgltvkCkskekeddvetRelvvkfd...deeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaii

IALEQLK-LENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILedivygdtaVTIDEFKDRCMKL
..   .  ....| .. ..  ||||| ....   .. |.  .|.         . . |..|. .. 
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.........llaievldqfaee
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1360-1566 1.5e-21 71.9 In-house 73-282 (305) alignment 
Range on Protein: 1360-1566
Range on HMM: 73-282/305.0
DSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLS----PADITTYSYIPPDVGDrQLKFGPLTVSVGRKQFNTGFSTRDISIFN-
||..  . |.|||   . .| . .| |.| . ||||||.   ..|. |.      .   . | |  ... . .||...| .  ..  ... .|...| . 
dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskte.kkefgefsvelksektasdyieRklkisie

EEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQgcLVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNL
.||. .  .   |  .   .     |  ....|.   |. .  .  . |.|.|   . |  |.| ..   |.|.||| ..|. .  ..   . .... .|
dedkesrtvlqyqltdWPdhGvpqfatsllslik..rvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl

QFYAYCYDCLLEY
. | ...| | |.
dqYvflhdaldel
DSPc_SM00195 1367-1566 1.5e-21 72.2 In-house 61-261 (263) alignment 
Range on Protein: 1367-1566
Range on HMM: 61-261/263.0
YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADI----TTYSYIPPDVgDRQLKFGPLTVSVGRKQFNT-GFSTRDISIFNEEDSSTLK
|..|.. .. .|    |...| | |||........ |. |.  .     . ..| | .  ... .|| ..| . ...     . .|.... .|... | |
yikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrk

LKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESChrgNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYD
.. .||..   ...   ......... .  . ..    ..||..| .   |  |.|.|. ..|.. ..|  .|. .  ..   | ||.. .|..|...|.
vtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiye

CLLEY
..|||
ailey
PTPc_SM00194 1367-1566 1.5e-21 72.2 In-house 61-261 (263) alignment 
Range on Protein: 1367-1566
Range on HMM: 61-261/263.0
YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADI----TTYSYIPPDVgDRQLKFGPLTVSVGRKQFNT-GFSTRDISIFNEEDSSTLK
|..|.. .. .|    |...| | |||........ |. |.  .     . ..| | .  ... .|| ..| . ...     . .|.... .|... | |
yikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrk

LKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESChrgNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYD
.. .||..   ...   ......... .  . ..    ..||..| .   |  |.|.|. ..|.. ..|  .|. .  ..   | ||.. .|..|...|.
vtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiye

CLLEY
..|||
ailey
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1070-1175 9.1e-21 69.0 In-house 48-164 (350) alignment 
Range on Protein: 1070-1175
Range on HMM: 48-164/350.0
QTKNRYRDVGAFDHTRVTLQE----IPGVPHSH----YINANFIKGY-----HDDKL-YIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCH
 .||||...  ..|.|| |..      .. ||.    |||||..|        . .  |||||.|  .| |||.... .     |..||...|    ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPSSGqccYGDIAVRVDR
.||.  .   | || |..  
rYWqegs...ydditvklas
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1359-1567 2e-20 68.3 In-house 82-290 (298) alignment 
Range on Protein: 1359-1567
Range on HMM: 82-290/298.0
KDSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP---ADITTYSYIPPDVGDRqlKFGPLTVSVGRKQFNTGFSTRDISIFNE
..| .    .|..|   | || .  | .|| | |||...... . |. | .    | |.|.   ||.| .  ..| .|||. .|.  . . .| . . ..
eesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskk

EDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGclVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQ
. ... ... ... .   |.    |   .....   |.|   . ||.|....     |  | |  .   |.|.|||. .|..|  .    . ||..   .
keekerevrqlhftsWpdkgvpenatsvldllrk..vrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqtee

FYAYCYDCLLEYS
 |...|.  ||. 
qYvfiyeavleal
subfamily_PTPRD_pd Subfamily PTPRD 1367-1569 2.8e-20 67.5 In-house 83-283 (564) alignment 
Range on Protein: 1367-1569
Range on HMM: 83-283/564.0
YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPDvgDrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKL
..||| ... .| .  |..|| | |||.. ..... |. |.           .| | .  . . ..| |||..  ..  . .. |.... ....|.. . 
fidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek..g.tetygeltVtleeeeeladyeirtfklkkkkssesreV

KYIQYQEMLLKQCFPRADKFIKFIQGclVEAEScHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDC
.  .. .   .     | .....|.   |.| . .....||..|     |  |.| .. ..|.|.|.|. .|. |  ..   | . .. . . |..... 
rqFhFtsWPdhgvpesatslLdlirk..vraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFihea

LLEYSDK
.||. ..
ilealac
subfamily_CG42327_pd Subfamily CG42327 1232-1301 8.1e-20 65.7 In-house 241-311 (319) alignment 
Range on Protein: 1232-1301
Range on HMM: 241-311/319.0
ANDKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLE-NKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAI
.  .|..||.||||| ||||||..|| |||...|.   . |||  .| ..|..| . |..  || ||.. .
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1069-1306 9.2e-20 65.4 In-house 47-280 (303) alignment 
Range on Protein: 1069-1306
Range on HMM: 47-280/303.0
DQTKNRYRDVGAFDHTRVTLQEipgvphSHYINANFIKgYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPSSGQ-CCYG
.  |||. ||  .||..| | .      | || |....  . .|  | || |   |. |||.|. ||.   ...|    |  |   .  .|   .   . 
nmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

DIAVRVDRNIELPHYTIRGFKVFNERDTTEKErTVLQFHYTAWPDRNVPAQ-ASHVLDFLRAINSANDKEE-YGPIVVHCSAGVGRTGTIIALDIALEQL
. ..||    ..       .||    . . |   .   || |||  ..|.. .....  .  ..|   |     | |    .|.||.||.  .. |   |
ersirvgefkrvelgdgwvlkvlsvsngdyks.flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

KLEN-KVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIV
. |.  .|.   .  .|. | . || |.|. ...  . | ..
hseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
0045098 (Phosphotyrosine protein) phosphatases II 1367-1567 1.2e-19 66.2 In-house 58-272 (278) alignment 
Range on Protein: 1367-1567
Range on HMM: 58-272/278.0
YLDGYwtPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNE----EDSS
|.|||  |. ||    |...| . |||.. .. .|.|..| .      .  . | |.   .  | .|..|| .   . .  . .|.. . |     ||  
yidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe...ggsltygdftvtllseevlddytlrtllvtnltveredle

TLKLKYIQYQEMLLKQCFPRA-----DKFIKFIQGCLVE-------AESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAkkERIIDLLQSANHHYLQC
........|  .    . .       .....||. .| .         ... ...|.|.|     |  | .. . ..|..   |. .|||.  ..   | 
srgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqR

PG-LIVNLQFYAYCYDCLLEYS
||  . ||..| ..|..|||. 
pglavqnleqyrflyefllell
subfamily_CG7180_pd Subfamily CG7180 1362-1566 3.2e-19 63.7 In-house 72-289 (296) alignment 
Range on Protein: 1362-1566
Range on HMM: 72-289/296.0
KFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP-ADITT--YSYIPPDVgdrQLKFGPLTVSVGRKQFNTGFSTRDISIFNE----
   . | |..  .. .|    |.||| . ||||. ..|.  ...|.   | .    ||.|..    . ..|.. | . ...  . . .| . .  .    
YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks...keqygeifveiveekqyanlkirtfkltkkival

------EDSSTLKLKYIQYQEMLLKQCFPRA-DKFIKFIQGCLVEAESC--HRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQ
      ..  |  .| .|..|  |.. .|     .|....   .  |    .  . |....     . .|.. ..  .|. ..||  .|. . .     .
teqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrs

CPGLIVNLQFYAYCYDCLLEY
 |.|. | . | |.|| |||.
RpqLvenveeYkyiYdvllea
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1359-1567 5.9e-19 63.3 In-house 72-280 (318) alignment 
Range on Protein: 1359-1567
Range on HMM: 72-280/318.0
KDSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADIT----TYSYIPpdvGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFN
..| .  . |.|||   . .| . .|  || | |||.. . ... |. |.            | |   ..   ..| |.| .  .   . .  | ... .
egsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP...skgsrsygklvvelkeevelsdyvlrefkvtr

EEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGclVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNL
.| ... . .  .| .   .     . .......   |..   . |..||..|  .  |  |.| ..   |.|.|.| ..|..|  ..   | . ..   
teeeesrqvrqyhytsWpdegvpesgaslldlvrq..vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqte

QFYAYCYDCLLEYS
. | ..|| |||. 
dqyefiydvlleal
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1365-1570 8.5e-19 62.5 In-house 81-286 (290) alignment 
Range on Protein: 1365-1570
Range on HMM: 81-286/290.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPPDvgDRQLkFGPLTVSVGRKQFNTGFSTRDISIFNEEDSsTL
  |..||   . .|   .|...|   ||.||.|...| |. |         . . | |    | .  .|. .. .   .  ... .| ... |.. .   
AcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtka.ygefsikllneetlneyierklevknknsa.ga

KLKYIQYQ--EMLLKQCFPRADKFIKFIQGclVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAY
| . .|||   .  .   .     .  |.   ..    .|||..|..|  .. |  ..| ..|  ....|.|  ||..|  ..   | ||..   | | .
kqsvtqyqitnwdstgkvtnpqtillviee..myktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqg

CYDCLLEYSDKL
 .. .|.| |..
ifqivltyldsf
0037934 (Phosphotyrosine protein) phosphatases II 1371-1566 1.1e-18 63.1 In-house 43-241 (243) alignment 
Range on Protein: 1371-1566
Range on HMM: 43-241/243.0
YwtPNlFIKSPSPTKETEEL----FWRLIVQNECTHIINLSPAD----ITTYSYIPpdvgDRQlKFGPLTVSVGRKQFNTGFSTRDISIFNEE-DSSTLK
.  |. .| .  |..|| |     |||.. .. .|.|..| . .    .  . | |    . .  .|..|| .   .   ..  | ... | . |  |. 
t..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....gev.tygdftvtllseehlddytvrtlllenldlddltrl

LKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAES-----CHRGNHPILIHDDGSNGPVGIFATLAYCLQRAkkeRiIDLLQSANHHYLQCPG-LIVNLQF
   ..|  .   .. .  . ...|.. .    |.     .  ...|.|.|  .  |  | .... ..|..    . .||..  ..   | ||  . ....
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsq

YAYCYDCLLEY
| ..|..|||.
yrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1357-1568 2e-18 61.5 In-house 33-243 (250) alignment 
Range on Protein: 1357-1568
Range on HMM: 33-243/250.0
TDKDSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHII---NLSPADITTYSYIPPDVgdrQLKFGPLTVSVGRKQFNTGFSTRDISIF
.||.| .  . .|.||   ..|| . .| ..| | |||...... . |.   ||.  . |   |.| ..     |.| .|||.  |.  . . .| . . 
gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvek...aekyGdvtvsllskeefadytkrklkls

NEEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGclVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVN
... ..   .. ...     |     |   .....   |.|.  . || |....     |  | | ..   |.|.|||...|. .  .    . |. .  
kakkaderivrqlhfvvWPdkgvPevatavLellkk..vqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphaves

LQFYAYCYDCLLEYSD
|. | ..|  .|.. |
leqyvfvyeiilkald
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1364-1568 2.1e-18 61.5 In-house 80-284 (319) alignment 
Range on Protein: 1364-1568
Range on HMM: 80-284/319.0
TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTYSYIPPDVGD-RQLKFGPLTVSVGRKQFNTGFSTRDISIfNEEDSS--TL
 . ..|||   . ||   .| ..| | |||.. ..|.  .. |.         .     .    ..| |.| .  ..   ..  |.... |.  |   | 
nasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetR

KLKYIQYQEMLLKQCFPRADKFIKFIQGcLVEAEScHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCY
..|  ||.|   ..   .|   .....  . .. . .  . || .|     |  | | .|   |.| |.| ..|. . ...  .| . .. . . | ..|
evkhfqyteWpdhdvPekatslldllkr.irksre.ktqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiy

DCLLEYSD
. |||. .
ealleave
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1356-1565 3.5e-18 60.6 In-house 72-277 (315) alignment 
Range on Protein: 1356-1565
Range on HMM: 72-277/315.0
ETDKDSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTYSYIPPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNE
|.|..|..  . ..|||  .. .| . .|  .. . ||||. ......|. |.       .       |... .|..||.   .. || .. | .|.  .
endphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfg

E-DSSTLKLKYIQYQEMLLKQcfpRADKFIKFIQGCLVEAESCHrgnHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNL
.     ..|.|  . .| . .    .  ....|.   .  ..      .|..| .   |  | | ||   |..|. |..||. .  .    .  ...  .
dnirevvqlhytswpdmgvpk...ytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqva

QFYAYCYDCLLE
. | . || |||
eqyqfiydalle
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1124-1311 5.3e-18 60.0 In-house 40-226 (255) alignment 
Range on Protein: 1124-1311
Range on HMM: 40-226/255.0
TTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS--SGQCCYGDIAVRVDRniELPHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASH
| | |....  ..| ..|||... |  . ||..|.|    ..  . |..| . .     .  .|  ..  .     | .||  ..|. |...| | .|  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VLDFLRAINSAndKeeygPIVVHCSAGVGRTGTIIALDIALE----QLKLEN--KVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILeDIVYGDTA
.|  |...  .  |    ..|||||.|.||. . .  ...      .|.  .  ..| . ... ||..||. ..   |  |    .| |.|.  ..
ilnilkvvrds..k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl.dlvfpkge
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1351-1574 6.6e-18 59.7 In-house 48-266 (267) alignment 
Range on Protein: 1351-1574
Range on HMM: 48-266/267.0
SIVPFETDKDSKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTY-SYIPPDVGDRQlKFGPLTVSVGRKQFNTGF--STR
..|.. | ..    . |..|| | | ||    | | |   |. .| ..... |. | .. .     . || .|. . |.  |||    .. .  .   | 
trvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqak.kyqdltvehslekeendyqiitl

DISiFNEEDSSTLKLKYiqYQEMLLKQcfpRADKFIKFIQGCLVEAeSCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCP
..  |..| .  . | |  |..  ..        ..| . | | .      ||.|.... .   |  | | ..   |.|||.| . |. .   .   | .
elk.fknesahnvtlyy..ykkwnint...nnkpylkplfgilakn.qlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqri

GLIVNLQFYAYCYDCLLEYSDKLLKEE
||.  .. | |... | ||..  ||||
glvdtkeryiyihellaeyaegrlkee
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1358-1568 1.5e-17 58.5 In-house 69-279 (287) alignment 
Range on Protein: 1358-1568
Range on HMM: 69-279/287.0
DKDSKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPPDVGdrqLKFGPLTVSVGRKQFNTGFSTRDISIFN
 ..    . ..|||   . || . ||  .|   ||.|| ... | |. |.      .   | | | .     . .|. ....  .. |.|.  |.. . |
ehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks...vvlGeyniellneevnagyierklevkn

EEDsSTLKLKYIQYQEMLLKQC--FPRADKFIKFIQGCLveAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIV
..  .. |..  |||    ..    ..    .  |.      .  .||| .|..|   . |  ..|   |  ....|.| .||..|  ..   | || . 
knk.agdkqqvkqyqitnWdstgkvtepqtillvieemy..ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvq

NLQFYAYCYDCLLEYSD
  . | . .| .||| |
tveqykfindivleyld
subfamily_PTPRK_pd Subfamily PTPRK 1350-1566 3.6e-17 57.2 In-house 60-276 (314) alignment 
Range on Protein: 1350-1566
Range on HMM: 60-276/314.0
PSIVPFETDKDSKF-TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD----ITTYSYIPPDvGdrQLkFGPLTVSVGRKQFNTGF
. ... . | .|..  . ..|.|  |. ||    | .|| . ||||. ...|. |. |.       .  . | | | .  .  .|.. | . . . .. .
vflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed.t..ev.ygdikvelvetellael

STRDISIFN--EEDSSTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESchrGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHH
 .|  .. .     . . ... .|.      .    |  ..|...      |    .. .|..|     |  |.| ...  |. ...|...|. . .   
vvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktl

YLQCPGLIVNLQFYAYCYDCLLEY
  . . ..   . | ..|| .|| 
rsrkvnmveteeqykfiydvilea
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1202-1302 3.7e-17 57.1 In-house 217-341 (350) alignment 
Range on Protein: 1202-1302
Range on HMM: 217-341/350.0
VLQFHYTAWPDRNVPAQASHV----------LDFLRAiNSANDKEEYGPIVVHCSAGVGRTGTIIALDIALE-------------QLKLENKV--DIKGI
|.|...  |.| ..  .   .          .| | | .|  |...  ||.||||||||||||...||  |.             .|.  .|.   |. |
vyqlqvknWkDlslllnPesilqalevkndliddlfa.eshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VTFLRKQRKQMVQALCQYIFIHNAIL
|  ||||| .||| | |.|||..|.|
vnelrkqrismvqnldqfifiYeall
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1241-1306 1.4e-16 54.6 In-house 1-66 (69) alignment 
Range on Protein: 1241-1306
Range on HMM: 1-66/69.0
IVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIV
.|||||.| |||||.||. . . ..| |  |||   | ..|| |  ||    .|||||.|. | . 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Ptp69D_pd Subfamily Ptp69D 1365-1570 3.3e-16 54.3 In-house 81-289 (307) alignment 
Range on Protein: 1365-1570
Range on HMM: 81-289/307.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTY----SYIPPDvgdRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSS--
. .. ||   . || .  |  .| . |||.| . | | |. ||  . ..      | | .    . ..| . | . .... . .  |.... . ...|  
asfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...devqygdilvklvseekhsdyiiReldvskkkeesge

-TLKLKYIQYQEMLLK-QCFPR-ADKFIKFIQGClVEAESCHrgNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQF
   . | .||. .  |    |. |   .|.|.    | .. .  . ||..|     |  ||| .|.  ||. |.|  .|. .   .   | . |. .|. 
vedsrkvvqyhytgWkDskvPevargllklieqv.relykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleq

YAYCYDCLLEYSDKL
| ..|  ||.||.. 
Yvflyralldyssyg
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1363-1566 9.6e-16 51.9 In-house 74-275 (515) alignment 
Range on Protein: 1363-1566
Range on HMM: 74-275/515.0
FTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIIN---LSPADIT-TYSYIPPDVGDrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSS
| . |. .. . . .| |  | | . . ||||..|.. | |.    |.  |      | |   ||  .||| . |..   .  ||   | . .  ..|| 
fnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd.svkfGsikvelvsleactggikrkltvlkgddsr

TLKlkYIQYQEMLLKQCFPRADKFIKFIQGclVEAESChRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAY
|.     ...|   |   ...  ..|.|.   | |.   . .||..||     |  |.. ..  .. .||. |..|...  .    . | |.   . ||.
tvt..qfhfteWPdkGvpkhtssllklike..vkadhg.qythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyaf

CYDCLLEY
 |. .||.
iygavled
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1242-1308 1.2e-15 51.6 In-house 1-67 (69) alignment 
Range on Protein: 1242-1308
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDIVYG
|||||.| ||||| ||. . . ..| |  |||   | ..|| |  ||    .|.|||.|. | .  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_PTPRA_pd Subfamily PTPRA 1365-1572 1.5e-15 51.9 In-house 91-303 (330) alignment 
Range on Protein: 1365-1572
Range on HMM: 91-303/330.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPpDVGdrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTL
. ..|||   . || .  | .|| | |||.| . . . |. |.      .   . | | | |   . .| ..|.|  ..    .. |.. . .  |..  
asfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP.deG..lvtyGnirvevedetvlvdytvrkflvqqlpdatre

KLK-YIQ-YQ-EMLLKQCFPRAD-KFIKFIQGclVEAESCHRGNhPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFY
| .  .. .  .   .   |      .|...   |..     .. || .|     |  | | .|   |.| | ||..|. .  ..  || | ..  .. |
kksrlvrqfhftswPdvGvPfepiGmlkllkk..vkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqy

AYCYDCLLEY---SDKLLK
 ..|  ||||    |  |.
efiykvlleyylygdteld
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1376-1565 2.8e-15 50.9 In-house 76-264 (283) alignment 
Range on Protein: 1376-1565
Range on HMM: 76-264/283.0
LFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPpDVGdrQLKFGPLTVSVGRKQFNTGFSTRDISIFNE-EDSSTLKLKYIQYQEM
 .| . || ..|   ||... ... | |. |..     .|    | |   |    ..|..||.. .   .  |. . . . ..    ||| | . |... 
kyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP.krG..sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW

LLKQCFPRADKFIKFiqgCLVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLE
|  .  .  . ..||    .| .   .  . ||..|     |  ..| ...  .. |. | ..|. .  .    | .... .|. |   ..  ||
leygeqaiinslvkf...nkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
0051429 (Phosphotyrosine protein) phosphatases II 1367-1571 3.6e-15 51.8 In-house 11-229 (272) alignment 
Range on Protein: 1367-1571
Range on HMM: 11-229/272.0
YLDGYWT---PNLFIKSPSPTKETEELFWRLiVQNECTHIINLSPAD----ITTYSYIP---------PDVGDRQLKFGPLTVSVGRKQFNTGFSTRDIS
...||.    |.... |. |.. |.. ||||  .. ...|..| . .      .. |.|         .| .. .  .| |.| .  ... . .  | . 
dvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrell

IFNE-EDSSTLKLKYIQYQEMLLKQCFPRAdkFIKFIQGCLVeaeschrgNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIID--------LLQSANH
. ..   . ....  ..|. ..     . |  ...... .|         ..|.|.|  .  .  |... | ..|..  .| |.|        |..  ..
ltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeavee

HYLQCPGLIVNLQFYAYCYDCLLEYSDKLL
   | || . . ..|...|..|||. ..||
lraqrpgavqteeqylflyeallellrsll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1362-1566 8.8e-15 49.3 In-house 74-276 (315) alignment 
Range on Protein: 1362-1566
Range on HMM: 74-276/315.0
KFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINL---SPADI-TTYSYIPPDVGDrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDS
 . . |. .. . . .| |  | | . . |||...|.. | |. .   .  |      | |   .|   .|| . |..   . .|.  .| . . . |.|
yinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad.svefGsikvellsleadtdgvarklvtrksees

STLKlkYIQYQEMLLKQCFPRADKFIKFIQGclVEAEsCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYA
 |.     |..|   |    ..  ..|.|.   | |.  .. ....|.|     |  |.. ..  .....|..| .|...  .    . | |.   . ||
rtvt..qfqftewPdkGvdkqtssllklike..vkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeya

YCYDCLLEY
. || .||.
fiydavled
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1361-1420 1.4e-14 48.4 In-house 77-135 (439) alignment 
Range on Protein: 1361-1420
Range on HMM: 77-135/439.0
SKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAdITTYSYIPPD
  ... |..||....|.|... |.||| . ||||.... ...|..|.   . .| | | |
hyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnl.vesykywpsd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1366-1566 2.3e-14 48.6 In-house 59-254 (284) alignment 
Range on Protein: 1366-1566
Range on HMM: 59-254/284.0
YYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSpADiTTYSYIPPDVGDrqlKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTlKLKYI
 .. ||  .. .| .  | ..| . |||.| . .|. |. |.  |     | | ..     | .   |.|   .    .  ||| . ..      . |  
sfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.kd.kcsqywplkivi...keerfkvkvdsveeseeyvvrdielsedgkekd.irkir

QYQEML-LKQCFPRAD-KFIKFIQGcLVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCL
|.  .   ..  |    .......  .   .| ......|..|     |  |.. .|   |.| |.|. .|. .  .    | . |. .|  | ..|  |
qfhflgwpdvgvpdypsdlmrlvkk.vrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal

LEY
|| 
lee
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1366-1565 3.7e-14 47.7 In-house 95-289 (319) alignment 
Range on Protein: 1366-1565
Range on HMM: 95-289/319.0
YYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSpADiTTYSYIPPDVGDrqlKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSsTLKLKYI
 ...||  .. .| .  | ..| . |||.| . .|. |. |.  |     | | ..     | .   |.|   .    .  ||| . ..    . . |  
sfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.kd.kcsqywplkivi...keerfkvkvdsveetaeyvvrdielsedgke.kdirkit

QYQEMLL-KQCFPraDKFIKFIqgCLVE----AESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCY
|.  .   ..  |  |  ....  .||.     .|  .....|..|     |  |.. .|   |.| |.|. .|. .  .    | . |. .|  | ..|
qfhflGwpdvGvp..dypsdlm..rlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiy

DCLLE
  |||
salle
subfamily_hpo-7_pd Subfamily hpo-7 1124-1302 5.9e-14 46.6 In-house 46-224 (263) alignment 
Range on Protein: 1124-1302
Range on HMM: 46-224/263.0
TTDDFWRMVWEQRTVTIVMLTNLMESYKSKCHQYWPS--SGQCCYGDIAVRVDRNIElpHYTIRGFKVFNERDTTEKERTVLQFHYTAWPDRNVPAQASH
| | |....  ..| ..|||..  |  . || .|.|    ..  . ...| . . ..     ..  .. .  .   | .|| .. |. |...| | .|  
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

VLDFLRAINSAndKeeygPIVVHCSAGVGRTGTIIALDIALE----QLKLENK--VDIKGIVTFLRKQRKQMVQALCQYIFIHNAIL
.|  |..      |    ..|||||.|.||.      ...      .|.  .   .|   ... ||..||. ..   |  |    .|
ilnilkvarns..k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1365-1567 6.2e-14 46.7 In-house 80-279 (288) alignment 
Range on Protein: 1365-1567
Range on HMM: 80-279/288.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPdvGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFneEDSSTL
. |.||.   . .| . .|  .| . ||.|. .|. . |. |.      . .   | |   .|.. ..| .|| .  ..  . | .| . .    . . |
asyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd..adkpknyGsvtvtlveskeledfvlrkllle..kkktel

KLKYIQYQEMLLKQcFPR-ADKFIKFIQGCLVEAESChrgNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYC
...  ||.    ..  |. .  ......   |  ..      ||..|     |  |.| .|   ... ..|  ||..   ..   | . |. .|. | ..
eitqyqylaWpdhg.vPeskapllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefi

YDCLLEYS
|..||.  
yevllsli
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1201-1303 7.7e-14 45.8 In-house 219-342 (349) alignment 
Range on Protein: 1201-1303
Range on HMM: 219-342/349.0
TVLQFHYTAWPDRNVPAQA----------SHVLDFLRAINSaNDKEEYGPIVVHCSAGVGRTGTIIALDIALE----------QLKLENKV--DIKGIVT
 .||. .  |.|  .              ....| | | .   |...  ...|||||| ||||... ||. |.          ..||...    |  || 
ellqlqvknwldlslllnPisilqalevkndliddlfarly.ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

FLRKQRKQMVQALCQYIFIHNAILE
 ||||| .||| | |.|.|..|.|.
elrkqrismvqnlaqfiaiyealLk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1240-1305 9.1e-14 46.0 In-house 230-295 (297) alignment 
Range on Protein: 1240-1305
Range on HMM: 230-295/297.0
PIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFIHNAILEDI
...|||||||||.| ..  |. |..|. .   |.. |...||.|| ..||.| |. ....|.|. .
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_PTPRG_pd Subfamily PTPRG 1365-1566 1.5e-13 44.8 In-house 81-286 (563) alignment 
Range on Protein: 1365-1566
Range on HMM: 81-286/563.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPPdvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFN----EED
  |.|||   . || .  | |.| . |||.| ... . |. ..            | |    |  ...| |.|   ...  .  ..| ..| |    ...
AnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk...desetygalqvtlieeevlalytvrtlviknlklkkkk

SSTLKLKYIQYQEML-LKQCFPRADKF-IKFIQGClveAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQ
.   ... .||.      .. |    . ..|..     . . ..   ||..|..   |  |..  |   |.. ..| ...... . |  .| . |. .  
qcdteklvrqyhytkWPdhgvPehslpvLifvkks...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteE

FYAYCYDCLLEY
 | . .| ||| 
qYiflhdallea
subfamily_PTPRB_pd Subfamily PTPRB 1364-1568 2.7e-13 44.6 In-house 83-286 (293) alignment 
Range on Protein: 1364-1568
Range on HMM: 83-286/293.0
TSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPDvgDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDssT
 . |..||..|. || .  |  || . |||.. ..... |. |        .    | | |  ...  .| ..|..  ..  . . .|...| .|..  .
nanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad..eepvlyGdikvtlvaeeeledwvirelkiekeke..e

LKLKYIQYQEMLLKQCFPRADKFIKFIQGCLvEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYC
 |..  ...         .......|..    || . .  ..||..|     |  |.| .|   ||. ..| ..|..    .   .   |. . . | . 
rkvrqyhftsWpdhgvPektktlldfvrtvr.eaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifi

YDCLLEYSD
..|.|..  
hqcvldllr
subfamily_PTPN9_pd Subfamily PTPN9 1363-1569 9.7e-13 42.8 In-house 73-292 (297) alignment 
Range on Protein: 1363-1569
Range on HMM: 73-292/297.0
FTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPPDVGDrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSS
  . ..|||  .. ||    | |.| . |||.. ..|.  |.          .    | |.. .. . .|| |.||.   . .  . .| . | | ... 
inanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees.saefgdlsvsnveveeeedykvrvleiknvktee

TLKLKYIQYQEMLLKQCFPRADKFIKF------IQGCLVEA----ESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPG
. |. . |.           | .....       |...|..    .  |  . ||..|     |  | |.|| .||.| ...  .|. .. ..   |   
srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqraf

LIVNLQFYAYCYDCLLEYSDK
 |   . |..|| ..|||. .
siqtpeqyefcylavleyale
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1356-1567 1.1e-12 42.8 In-house 68-288 (325) alignment 
Range on Protein: 1356-1567
Range on HMM: 68-288/325.0
ETDKDSKFTSY----YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLS---PADITTYSYIPPDVGDRQlKFGPLTVSVGRKQFNTGFSTRD
|| ||.  . |    ||  .   . |. . .|  .| . .|||... .|. .. |      .     | | ..|. . .||.| |..   .  . .  | 
etkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksk.tfGglevklrtieeisdyvhrv

ISIFNEEDSSTLKLKYIQYQEML--LKQCFPRA-DKFIKFIQGCLVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQ
. . . ..  |. .|  |.|       | .| .   ... ..       .  ..  |||.|     |  |.|..|   |..  .|  .|.... ..   .
ldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkd

CPGLIVNLQFYAYCYDCLLEYS
 | ..     |  .|..| |. 
rpsmvetvdqyiliyealveay
subfamily_eak_pd Subfamily eak 1038-1219 2.4e-12 40.9 In-house 17-198 (332) alignment 
Range on Protein: 1038-1219
Range on HMM: 17-198/332.0
NKQEIFNEIFEFINSTSPDYACIASLAAHEYDQTKNRYRDV-G--AFDHTRVTLQEIPgVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWE
||. |.| | . ||  .        |. .| .....  |.| .   .|.  | |       .  ||||  ..  .  . || |  ..|.    ||.|| |
nknhiwnrinqrinivadlddyqrllsisetarleavnrnvvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvle

QRTVTIVMLTNLMESYKSKCHQYWPSSG--QCCYGDIAVRVDRNIELPHYTIRGFKVFNERDTtekeRTVLQFHYTAWPDRNVPAQA
|.. .||.| . .|    |  .|.|  .  .  .| . |     ..   .  | ...    .|      || ...  | . ..|   
qkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnet....hrvlhykvfGwtettlpkye
0036282 (Phosphotyrosine protein) phosphatases II 1366-1561 2.7e-12 42.2 In-house 8-164 (174) alignment 
Range on Protein: 1366-1561
Range on HMM: 8-164/174.0
YYLDGYWTPNLFIKSPSPTKeteelFWRLIVQNECTHIINLSPADITT----YSYIPPdvgdrqlkfgpltvsvgrkqfntgfstrdisifneeDSSTLK
..||... .. .| .  |..     ||... .. .|....| .         . | |                                     ... |.
spldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................lredle

LKYIQYQEMLLKQCFP----RADKFIKFIQGCLVEaeschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKkERIIDLLQSANHHYLQCPGLIVNLQFYA
   |||. .      .      ..|.||.. .| |      ...|.|.|  .  |  |... . ..|.. . |. .| |.      ||.|| . . ..| 
rlgiqylylpwpDhgvpdlsillefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

YCYD
..|.
flyy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1070-1174 3.7e-12 40.2 In-house 49-166 (349) alignment 
Range on Protein: 1070-1174
Range on HMM: 49-166/349.0
QTKNRYRDVGAFDHTRVTLQEIP----GVPHSH----------YINANFIK--GYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESYKSK
 .||||.|.  ..|.|| |.. .    .. .|.          |||||..|   .  .| ||||| |   | |||....  ..   .. |..  |    |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHQYWPssgQCCYGDIAVRVD
|..||    .  | .| |.. 
cdiywq...elsysnitvklq
subfamily_PTPN3_pd Subfamily PTPN3 1375-1568 7.3e-12 39.8 In-house 84-276 (280) alignment 
Range on Protein: 1375-1568
Range on HMM: 84-276/280.0
NLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPdVGDrQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEM
| .| .  | ..| . ||... ..... |. |        .  . | |   .| .|..| ..| . ... .. . .|.. . ..| .   |.  .|| . 
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.ted.eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaW

LLKQCFPRADKFIKFIQGCLvEAEscHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYSD
  ..    ...|..|..    ..   .  ..|...|  .  |  |.. .|  .|.   ... .  |.   .   |   |. . . | .  ...|. ..
pdhgvPddsadflefvervr.klr..sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
0041856 (Phosphotyrosine protein) phosphatases II 1362-1566 1.3e-11 39.9 In-house 21-170 (182) alignment 
Range on Protein: 1362-1566
Range on HMM: 21-170/182.0
KFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSpaditTYSYIPpdvgdrqlkfgpltvsvgrkqfntgfstrdisifneedsSTLK
. . ....|.. .. ||    |...| . |.|.. .. .|.|.||.      . | |                                       . |.
yInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp.......................................elle

LKYIQYQEM-LLKQCFPRADKFIKFIQGCLVeaeschrGNHPILIHDDGSNGPVGIFATLAYCLQRakkeRiIDLLQSANHHYLQCPGLIVNLQFYAYCY
   |||. .     . |  |....||. .|         ..|.|.|  .  |  | .. . .....    . ..| .  ..   . || ......| ...
rlgiqylylpwpDhgvpdldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflq

DCLLEY
..|||.
lallel
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1365-1566 2.5e-11 37.9 In-house 70-276 (287) alignment 
Range on Protein: 1365-1566
Range on HMM: 70-276/287.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINL----SPADITTYSYIPPDvgDRQLKFGPLTVSV-GRKQFNTGFSTRDISIFNEEDSST
. |. .|   . || . .|   |   |||...... . .| .      |   .| | |    .. .. |  .| .  ... .  ...| . . . |   .
anyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer..evPmrvGGysvvlldydikePeygvralrlidletrea

LKLKYIQYQEMLLKQCFPRADKFIKFIQGC--LVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYA
  .| ... ..  |   | |  .|.|.  .   .|..    .  |...|||   |  ||. ..  ...| ..   .|  .   .   .  .|.     . 
rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlr

YCYDCLLEY
. |. |  |
llyealvty
0038934 (Phosphotyrosine protein) phosphatases II 1194-1258 2.6e-11 39.0 In-house 71-135 (194) alignment 
Range on Protein: 1194-1258
Range on HMM: 71-135/194.0
DTTEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIAL
|..| |.  ....   .||.... . . .|.||....  ... . | ..||| ||.|||||..| 
dpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1376-1566 4.2e-11 37.5 In-house 93-283 (297) alignment 
Range on Protein: 1376-1566
Range on HMM: 93-283/297.0
LFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTYSYIPPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQC
 .| .  | |.| . ||....... . |. |.  . .. .       .   .|| ..| .   .  .||. |.... ...  ..  .|  |. |   |. 
rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkav

fPRADKfIKFIQGCLVEAESCHRGN--HPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEY
 .| |. .. ..  . | .  . .|   |.|.|     |  |.. |.  .. .||.|  .|...  ..   . | |.   . |.. |  .||.
.erkds.assllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1064-1212 9.1e-11 35.8 In-house 91-232 (244) alignment 
Range on Protein: 1064-1212
Range on HMM: 91-232/244.0
AAHEYDQTKNRYRDVGAFDHTRVTLQEipGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESykskcHQYWPSSGQ
|    .  |||      ||  || | .  |     |||| |.        || || |  .|. |||.|. |.    .|.|  . |       .||| |  
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdsep

CCY--GDIAVRVDRNIELphYTIRGFKVFNERDTTEKERTVLQFHYTAWPD
  .   ||.| .    |.    |.  ..  | |  |  ...  |  . || 
lewyeeditvtltdrdef..knikasnleiesdmneshqaltmfqisnwps
subfamily_PTPN23_pd Subfamily PTPN23 1377-1571 1.2e-10 35.7 In-house 85-284 (288) alignment 
Range on Protein: 1377-1571
Range on HMM: 85-284/288.0
FIKSPSPTKETEELFWRLIVQNECTHIINLSPADITT----YSYIPPDVGDRQlKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMlL
|| . .| ..|   ||......    |. |   . .      .| | | |. . |||.|.|.. ...    .. |....  .. . . .....|...   
fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv.kfgdlsvtlksvretethvervlkletldadavksvshlqltsW.p

KQCFPR-ADKFIKFIQGCLV-EAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRA-KKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEYSDK
.   |   .....|..       .  .. . |...|     |  |.|| .   ..   |.. ..|..|  ..   |    . . . .  .|.  ||.  .
elGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

LL
 |
vl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1365-1571 1.4e-10 35.7 In-house 74-280 (281) alignment 
Range on Protein: 1365-1571
Range on HMM: 74-280/281.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIIN----LSPADITTYSYIPpDvGDRQLKFGPLTVSVGRKQFNTGFSTRDISIfNEEDSSTL
. ...||  .. .| . .|  .. . ||....... . |.     .    .  . | | | .. .||.| .||.  ... .. . .| ... ..|.. | 
anfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.d.dnselkygdvtvkstaeeekatyierkfkl.eresgetr

KLKYIQYQEMLLKQCFPRADKFIKFIQGclVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKE-RIIDLLQSANHHYLQCPGLIVNLQFYAYC
... ..|.    .     . ....| .   |.  . .. ..|..||     |  | . .|   ......| . .|. .  ..   .   ..  .  |.. 
eveqlaytaWPdhGvPattkellefrke..vlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefv

YDCLLEYSDKLL
|  .|.. || |
ykavldaldkel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1043-1109 1.6e-10 34.9 In-house 24-87 (440) alignment 
Range on Protein: 1043-1109
Range on HMM: 24-87/440.0
FNEIFEFINSTSPDYACIASLAaheYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINANFIKGYH
|.. . .. |   . . ||||     .. |||||.. |.||.|| |.|. |||.|.|||| .|.| .
fedewsllpsglsqpsdiaslp...nnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
Ig_2 Immunoglobulin domain 150-225 4.9e-10 31.3 Pfam-A 11-73 (80) alignment 
Range on Protein: 150-225
Range on HMM: 11-73/80.0
MSLNSSFVLNCTDDsGDPLSTFQWFKDDINITASTNPqlsitqytdrisyLTVTNVSPELAGSYKCATNN-GIGKSQ
.. .....|.|. . |.|  ..|| ||.  .. |.|              | . |||.| .|.| | . | . .|. 
vtegenvtLtCqap.gnptpkvqwykdgeelsqsqna.............lfipnvsaedsGtYtCrasnsegskqs
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1026-1119 8.4e-10 32.7 In-house 8-95 (95) alignment 
Range on Protein: 1026-1119
Range on HMM: 8-95/95.0
DEFQEHVEKLDKNKQEIFNEIFEFINSTSPDYACIASlaaHEYDQTKNRYRDVGAFDHTRVTLQEipgVPHSHYINANFIKGYHDDKLYIATQG
  |. || ..  | .. |.. |  |. ||     . |    | .  |||. ..  .| |||.|        | |||| |. ||   . |||.||
svfhshvlemhsnsdqefdnefksismtsgapytvgs...seanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
I-set Immunoglobulin I-set domain 150-230 9e-10 30.2 Pfam-A 12-88 (90) alignment 
Range on Protein: 150-230
Range on HMM: 12-88/90.0
MSLNSSFVLNCTDdSGDPLSTFQWFKDDINITASTNPQLSITQytdRISYLTVTNVSPELAGSYKCATNNGIGKSQAVADI
.| ..|  |.||  .|.|  ...|.||. ... | . ... ..    .. ||..||... .|.|.|  .| .||..| | .
vseGesvelectv.eGepepsvsWakdgselkssqrvkvtvee...aeytLtIsnvevsDeGkYtckatnsagkaeakaeL
PTEN_1 1191-1257 9e-10 33.7 In-house 83-149 (196) alignment 
Range on Protein: 1191-1257
Range on HMM: 83-149/196.0
NERDTTEKERTVLQFHYTAWPDRNVPAQASHvLDFLRAINSANDK-EEYGPIVVHCSAGVGRTGTIIA
...| .| ..  ....   ..| ..|  ... .|... . ..  . .. . ..||| ||.||.||..|
rsydleeffksgveylhfpieDhgapslsel.fdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
0043147 (Phosphotyrosine protein) phosphatases II 1366-1560 9e-10 34.0 In-house 11-154 (172) alignment 
Range on Protein: 1366-1560
Range on HMM: 11-154/172.0
YYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAdittysyippdvgdrqlkfgpltvsvgrkqfntgfstrdisifnEEDSSTLKLKYI
.|||.|. |. ||    |. .| . |||.. .. .|||.|| .                                             . | . |.  .|
syldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpellerlgi

QYQEMLLKQ----CFPRADKFIKFIQGCLveaesCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANhhylqcPGLIVNLQFYAYCY
||. .         .   ..|..||.  |     . . ..|.|.|  .  |  | .. . ..|.. . | ...|....       || . | ..| ..|
qylylpwpDhgvpllellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylmllglsleeavalvrekR......pgavqnpsqyrfly
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1364-1570 1.1e-09 32.8 In-house 61-271 (274) alignment 
Range on Protein: 1364-1570
Range on HMM: 61-271/274.0
TSYYLDGYW-TPNLFIKSPSPTKETEELFWRLIVQNECTHIINLS---PADI-TTYSYIPPDVGD-RQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDs
 . |. ||  . . ..    |  .| . |||.| |.|.. |. |     |.      | | . .   . ..| . . |  .  . ..| | ... . |. 
nanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.

sTLKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYA
 . ..|.. | .   ..   .|........    ..|. .    |...|     |  |.| .   .... ..| ..|.|.   .  |.  |.. . . | 
.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqye

YCYDCLLEYSDKL
. .  | .|  .|
lihralclylkrl
subfamily_PTPDC1_pd Subfamily PTPDC1 1202-1297 1.6e-09 32.4 In-house 82-168 (182) alignment 
Range on Protein: 1202-1297
Range on HMM: 82-168/182.0
VLQFHYTAWPDRNVPAqASHVLDFLRAINSANDKEeygPIVVHCSAGVGRTGTIIALdialeQLKLENKVDIKGIVTFLRKQRKQMVQALCQYIFI
 . ..  .|.| .|..   ..||  . ...| ...    . ||| || |||| .||       |   .... .  ....|..| . .|.  |  ..
giyvynfgwkDygvas.leriLdivkvvafalqeg...kvavhChaGlGrtGvliac.....ylvyakrltaekaiklvrskrpksiqtreqvelv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1365-1566 2.2e-09 31.4 In-house 75-292 (301) alignment 
Range on Protein: 1365-1566
Range on HMM: 75-292/301.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADIT----TYSYIpPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSS--
. |.|||   . || . .| |.|   |||||.|.  ..|. .   . .    .. |  |.   .. .|||.|| .  .|    |  |....  .. |.  
asyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqyw.pnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnng

----TLKLK-------YIQYQEMLL--KQCFPRADKFIKFIQGCLVEAESChrGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQ
    ..| |        .|.|          .     .. |.  .    .   |  |...|   . .  |.. ..   |  .| | ..|. |  .    .
yierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki..gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrs

CPGLIVNLQFYAYCYDCLLEY
 || .  |. |   || . .|
kpgaVtTLeqytsiydvidmy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1365-1564 2.6e-09 30.9 In-house 226-435 (440) alignment 
Range on Protein: 1365-1564
Range on HMM: 226-435/440.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTYS-YIPpdVGDRQLKFGPLTVSV-GRKQFNtGFSTRDISIFNEEDSSTLKL
   ..||   | || .  |   |   ||||. . . . || |   .  | | | |  |  | . |||.||   | ...|     | . .   |.   .. 
qqefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywp..vntrsvtfgpftvghkgsenmn.rvkvrtlelkykeevheirq

-------KYIQYQEML-LKQCFPRADKFIKFIQGCLVE--AESCHRGN-HPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIV
        .|| . .   .||.    ... ... | ..  .|    |.  |||.|        |.| |.  ||.. ...  ||..|      |  | .. 
fevqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvp

NLQFYAYCYDCLL
 |  |  ||  | 
tltdyllcykllt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1365-1564 5.8e-09 30.5 In-house 35-236 (237) alignment 
Range on Protein: 1365-1564
Range on HMM: 35-236/237.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSP----ADITTYSYIPPdvGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTL
.|  .   ||. .| .  | . . . ||... |. |. |. |.      ..  . | |    |.   .| ||||. .|.  . .. | . ....     .
tylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps..tdqpaaygvltvslkkkeefsdytvrslllskrltlkev

KLKYiQYQE-MLLKQCFPRAD-KFIKFIQGcLVEaESCH-RGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYA
.| . |||     ..  |.    ...| .  ... .| |     | .||     | .|||  .   |..||.....|. .       . | .|   . | 
rlih.qyqftswpdrgvpqqtaallrfrkn.iin.rsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyv

YCYDCLL
. .. .|
fihqtil
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1106-1163 9.7e-09 29.0 In-house 230-284 (440) alignment 
Range on Protein: 1106-1163
Range on HMM: 230-284/440.0
KGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMEsykSKCHQYWPSSGQ
.||   . .|||| | . |  ||||.| . |  ||.|| .| .     |  |||   .
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntr
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1072-1154 1.1e-08 29.0 In-house 37-118 (332) alignment 
Range on Protein: 1072-1154
Range on HMM: 37-118/332.0
KNRYRDVGAFDHTRVTLQEIPGvpHSHYINANFIKGYHDDKLYIATQGPKEETTD-DFWRMVWEQRTVTIVMLTNLMESYKSKC
 ||   . .|||.|| |    |  .  . ||... ||     || .| | .. |.  ||||| |..   |... .. |  | |.
mnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1065-1143 1.3e-08 28.7 In-house 33-116 (347) alignment 
Range on Protein: 1065-1143
Range on HMM: 33-116/347.0
AHEYDQTKNRYRDVGAFDHTRVTLQ-----EIPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVML
  | . .||| .||   | ||| |        .  .   ||||  ||    .| || || |  .|  |||.||   .   .| .
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
0049260 (Phosphotyrosine protein) phosphatases II 1367-1561 1.7e-08 29.8 In-house 1-144 (152) alignment 
Range on Protein: 1367-1561
Range on HMM: 1-144/152.0
YLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADITTYSYIPPDVgdrqlkfgpltvsvgrkqfntgfstrdisifneedsstlklkyiQ
..|||. |. ||    |. .| . |||.. .. .|.|..|   .  .. . .                                               |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

-----YQEMLLKQCFPRADKFIKFIQGClveaesCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANhhylqcPGLIVNLQFYAYCYD
        .   .     . ...||. .      ... ..|.|.|  .  |  | .. . ..|.. . | ...|.....      || . | ... ..|.
ylhlpwpDhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylmllgvsleeavalvrekR......pgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 1360-1568 4.5e-08 28.6 In-house 8-174 (176) alignment 
Range on Protein: 1360-1568
Range on HMM: 8-174/176.0
DSKFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPAD---ITTYSYIPPDVGDRQLkfgpltvsvgrkqfntgfstrdisifneed
.  . .| .....  ...|    |. .| . |.... .. .|...||            ...|.. . ..                              
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

sstlKLKYIQYQEMLLKQCfPRADKFIKFIQGCLveaeschRGNHPILIHDDGSNGPVGIFATLAyclqRAKKERIIDLLQSANHHYLQCP-GLIVNLQF
    . ...   ..   .     .....||. .|       . ..|.|.|  .  |  | .. .       ..|. .....   .   | | | . . ..
....qylhlpwpDhgvpdl.elllellefireal.......keggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

YAYCYDCLLEYSD
| ..|...|.. .
yrflyefellllk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1367-1571 6.1e-08 27.0 In-house 55-268 (270) alignment 
Range on Protein: 1367-1571
Range on HMM: 55-268/270.0
YLDGYW-TPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPADI----TTYSYIPPDVGD-RQLKFGPLTVSVGRKQFNTGFSTRDISIFneEDSSTL
|. |.   .. .| . .|.. | . |||.|.... | |. ...           | |.....  .|..| ..| .  .. ..|. .. . .   |.... 
yvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeer

KLKYIQYQEMLLKQCF------PRADKFIKFIQGCLVEAESCHRGNhPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQ
.|   .|..   .          ..|. .| ..      .. .... |.|.|.    |  |.. .| ....  .... .|.|.  ..   . . |.   .
rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpe

FYAYCYDCLLEYSDKLL
 |.. |  ..|| ....
qyeflykavveyaerra
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1043-1224 6.9e-08 25.6 In-house 5-163 (169) alignment 
Range on Protein: 1043-1224
Range on HMM: 5-163/169.0
FNEIFEFINSTspDYA-CIASLAAheyDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINAnfikgyhddklyiatqgpkeettddfwRMVWEQRTVTIV
.||. ||..    .|   .| |..   ..||||     |  |||| || .     | ||||                           ||.||  .  ||
ynelkefmkti..eynnfmaeltc...netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasviv

MLTNLMES--YK--SKCHQYWPSS--GQCCYGDIAVRVDRNIELPHYTIRGFK---VFNERDTTEKERtVLQFHYTAWPDRNVPAQASHVLD
.| .  .   .    . .|  |.   |.     . || |.   . .     |.   |. . | .  |. .  .||..||.  ||    ||  
vlgdtddknnfwpekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvtek.lsllhystwpqngvpqspvhvgh
I-set Immunoglobulin I-set domain 243-332 7.3e-08 24.1 Pfam-A 7-90 (90) alignment 
Range on Protein: 243-332
Range on HMM: 7-90/90.0
PLNSSVPVGQSIQLLVHFIGGyPLPTVTWYRLlG-ITN-SNRVPITDPRasasgqYSLNLTITNSSLSDDGLYLLMINNTIGAIEIEFNVTI
. .  | .|.|..| ..  |  | |.|.|..  |  .. |.|| .|          .  |||.| . || | | . ..| .|  | ......
lkdvevseGesvelectveGe.pepsvsWakd.gselkssqrvkvtvee......aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1091-1212 2.3e-07 25.2 In-house 7-123 (130) alignment 
Range on Protein: 1091-1212
Range on HMM: 7-123/130.0
IPGVPHSHYINANFIKGYHDDKLYIATQGPKEETTDDFWRMVWEQRTVTIVMLTNLMESykskcHQYWPSSGQCCYGDIAVRVDRNIELPHYTIRGFKVF
.  ..  .||||.|.      . |. || |  .|. |||.|. |.    .|.|  . |       .||| |    . .  . |          |.  .. 
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefknikasnle

NERDTTEKERTVLQFHYTAWPD
 |.|  |  ...  |. . || 
iesdlneshqaltmfqisnwps
subfamily_PTPN12_pd Subfamily PTPN12 1365-1572 3.4e-07 24.4 In-house 73-282 (290) alignment 
Range on Protein: 1365-1572
Range on HMM: 73-282/290.0
SYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLS---P-ADITTYSYIpPDVGDRQLKFGPLTVSVGRKQ-FNTGFSTRDISIFNEEDSSt
. .. |   .  .| . .|  .| . |||.| . . . .. .      . .    |  |. |...|.||...|.. ... .. .|  | . . ....|  
anfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW.peegeeelefgefevtleeekavdddflirtLkveaqkesr.

lKLKYIQYQEMLLKQCFPRADKFIKFIQGCLVEAEschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERI---IDLLQSANHHYLQCPGLIVNLQFY
 |.. ..|..   ...  .|.. ...|.      |   . ..|...|     |  |.  .. |  .  |.|.|   .|. .   .   | . |.   . |
.kvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqy

AYCYDCLLEYSDKLLK
 . | ...|.  | |.
elvykavaelvqkele
subfamily_DSP23_pd Subfamily DSP23 1210-1290 4.7e-07 24.6 In-house 59-131 (148) alignment 
Range on Protein: 1210-1290
Range on HMM: 59-131/148.0
WPDRNvPAQASHVLDFLRAINSANDKEEygPIVVHCSAGVGRTGTIIALDIALEQlklenKVDIKGIVTFLRKQRKQMVQA
 .|   |     | .|.| .. |..|.|   . |||  | |||||..|  .  |.     |.     .. .|..|   |..
iddyh.ppaleqvvefvrvveeaeekne..avsvhcllgrgrtgtmlacylvker.....klaaaeaiaevrrlrpgsvet
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1043-1223 5.1e-07 22.7 In-house 4-161 (169) alignment 
Range on Protein: 1043-1223
Range on HMM: 4-161/169.0
FNEIFEFINSTspDYA-CIASLAaheYDQTKNRYRDVGAFDHTRVTLQEIPGVPHSHYINAnfikgyhddklyiatqgpkeettddfwRMVWEQRTVTIV
.||. ||..    .|   .| |.    ..||||     |  |||| || .     | ||||                           ||.||  .  ||
ynelkefmkti..eynnfmaelt...cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasviv

MLTNLMES--YK--SKCHQYWPSS--GQCCYGDIAVRVDRNIELpHYTIRG-FKVFNERDTTEKERTV--LQFHYTAWPDRNVPAQASHVL
.| .  .   .    . .|  |.   |.     . || |.        . | |.|    .  ... |.    .||..||.  ||    || 
vlGdtddknnfwpekedyqlhpavilGewytdslyvrtdkvhpn.tsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvg
subfamily_CDC14_pd Subfamily CDC14 1214-1293 6.6e-07 23.5 In-house 245-313 (328) alignment 
Range on Protein: 1214-1293
Range on HMM: 245-313/328.0
NVPAQAsHVLDFLRAINSAndkeeYGPIVVHCSAGVGRTGTIIALDIaLEQLKLenkvDIKGIVTFLRKQRKQMVQALCQ
 .| .|  |  ||.....|      | |.||| ||.|||||.||  . ... ..      . ....||  |  .| .  |
stPsda.ivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacyl.mkhyrf....taaeaiawlricrPGsvigpqq
subfamily_PTEN_pd Subfamily PTEN 1185-1295 6.9e-07 24.4 In-house 60-170 (184) alignment 
Range on Protein: 1185-1295
Range on HMM: 60-170/184.0
RGFKVFNERDTTEKERTVLQFHYTAWP-DRNVPAQASHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIaLEQLKLENKVDIKGIVTFLRKQ
  .|..| |   . . . .. . . .| | . |.. . . .... |..  ....   .|||| || ||||..|.  . |..|.||.. ... . .  | .
dhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayl.lkslllekaeealelfaeaRtk

RKQMVQALCQYI
 |. |.   |  
nkkgvtiPsqrR
subfamily_PTPN14_pd Subfamily PTPN14 1377-1566 8.1e-07 23.3 In-house 95-295 (300) alignment 
Range on Protein: 1377-1566
Range on HMM: 95-295/300.0
FIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPD-VGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEML
.| . .| . | . ||... ... . |. |          ...|.| .    ....||   |.   ..  . . |. . .     .   .. ..||..  
yivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWp

LKQCFPRADKFIKFIQGC---LVEAES---CHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLE
 ... .  ..|.....       ...|    .  . |.|.|     |  |.  .    ..  .... ||. .. ..   |   |. .|  | . |. |..
dhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

Y
|
y
subfamily_PTPN13_pd Subfamily PTPN13 1380-1566 8.4e-07 23.5 In-house 82-268 (273) alignment 
Range on Protein: 1380-1566
Range on HMM: 82-268/273.0
SPSPTKETEELFWRLIVQNECTHIINL----SPADITTYSYIPPDVGDRQLKFGPLTVSVGRKQFNTGFSTRDISIFNEEDSSTLKLKYIQYQEMLLKQC
.  |  || . ||... . ... |. .        .    | |   ...    . |.|.. . |   ||. |.. . . | . . ..  ... .    . 
cqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgv

FPRADKFIKFIQgclvEAESCHRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLEY
   |.....|..    |  . .. . ||..|     |  |.. |.   |.  .... .|. .  ..   |  |..   . | ..|  .|| 
Pssaaellqfva....evrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
PTPc_DSPc_SM00012 1462-1565 9.1e-07 24.4 In-house 5-105 (105) alignment 
Range on Protein: 1462-1565
Range on HMM: 5-105/105.0
LKYIQYQEMllkqCFPR-ADKFIKFIQGCLVEAESCHRgNHPILIHDDGSNGPVGIFATLAYCLQRAKKE-RIIDLLQSANHHYLQCPGLIVNLQFYAYC
..| .....    . |. .|....... .  . . . . ..|...|.    |  |.|..|...||. .|| . .|..|  ..   | ||.. ... | ..
yhytgwpdh....gvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YDCLLE
|..|||
yralle
PTPc_motif_SM00404 1196-1286 1.1e-06 23.6 In-house 43-123 (140) alignment 
Range on Protein: 1196-1286
Range on HMM: 43-123/140.0
TEKERTVLQFHYTAWPDRNVPAQASHVLDFLRAInsandKEEYGPIVVHCSAGVGRTGTIIALdialEQLKlENKVDIKGIVTFLRKQRKQ
 ......||         .. .. . ||||....     ... | ..||| ||| |..|.|.     . .. .......  . |....|..
ensgfqilqiplddnekdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSatliia....Ylmr.yrqlslaeayefvkerRpi
0049772 (Phosphotyrosine protein) phosphatases II 1362-1574 1.8e-06 23.4 In-house 74-287 (314) alignment 
Range on Protein: 1362-1574
Range on HMM: 74-287/314.0
KFTSYYLDGYwtpNLFIKSPSPTKETEELF----------WRLIV-QNECTHIINLSPADIT----------------------Tysyippdvgdrqlkf
 ... |.||.   . || .  |...| . |          ||... .   ...|  |  ...                      .               
yinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...............

gpltvsvgrkqfntgfstrdiSIFNEEDSSTLKlkyiqyQEMLLKQCFPR--------------------ADKFIKFIQGClveaeschRGNHPILIHDD
                     .. ...|  .||      .|.  .. |.|                     |.|..||. .        . ..|.|.|  
.....................neptaadlellk......eelydpelferlgikylripvpDgsaplledfdeflefieea........dkggpvlvHCk

GSNGPVGIFATLAYCLQR--AKKERIIDLLQSANHhYLQCPGLIVNLQFYAYCYDCLLEYSDKLLKEE
.  |  | |...||.. .     | ... ...... .   ||.| .|. | .....|||| ..|.|. 
aGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkflkkfy
subfamily_PTPN6_pd Subfamily PTPN6 1375-1569 2.3e-06 21.8 In-house 98-299 (306) alignment 
Range on Protein: 1375-1569
Range on HMM: 98-299/306.0
NLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA----DITTYSYIPPDvGDRQLkFGPLTVSVGRKQFNTGFSTRDISIFN-EEDSSTLKLKYIQYQE
. .| .    ..| . |||...|.... |. .           . | |    ...  .| ..|.  ... .. .  |..|. . ...... ..   ....
ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde.eekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfks

MLLKQCFPRADKFIKFIQGCLVEAESCH-RGNHPILIHDDGSNGPVGIFATLAYCLQRAKK---ERIIDLLQSANHHYLQCPGLIVNLQFYAYCYDCLLE
   . .    . ...|..    ..|... . . ||..|     |  | |  .   |.  .|   .  ||. .. . .  |  ||.   | | . |  . .
WPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

YSDK
| ..
yiet
0044763 (Phosphotyrosine protein) phosphatases II 1373-1565 2.6e-06 22.7 In-house 27-169 (178) alignment 
Range on Protein: 1373-1565
Range on HMM: 27-169/178.0
TPNLFIKSPSPtketeELFWRLIVQNECTHIINLSPADITT----YSYIPPDVGdrqlkfgpltvsvgrkqfntgfstrdisifneedsstLKLKYIQYQ
.|.|.. |  |     . ...|. .. .|||.||.. .       . | | . |                                     .. ..| . 
lpglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.....................................iqylhipip

EMLLKQCFPRADKFIKFIQGCLveaescHRGNHPILIHDDGSNGPVGIFATLAYCLQRakkeRIiDLLQSANHHYLQCPgLIVNLQFYAYCYDCLLE
 .   . .   ..|..||. .|      .. ..|.|.|     |  | .. . .....    .. .| .  ..   . |  . |  .. ..|.. |.
Dhgvpdllehflefvefieeal......dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1362-1574 2.8e-06 21.0 In-house 75-241 (392) alignment 
Range on Protein: 1362-1574
Range on HMM: 75-241/392.0
KFTSYYLDGYWTPNLFIKSPSPTKETEELFWRLIVQNECTHIINLSPA---DittysyippdvgdrqlkfgpltvsvgrkqfntgfstrdisifNEEDSS
 . . |.... . . .| | .|   . . |||.. |.. | |. ..     |                                          . .|  
ylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........................................kgddar

TLklKYIQYQEMLLKQCFPRADKFIKFIQGclVEAESChRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHHYLQCPGLIVNLQFYAY
|      .. |   |.   ..  ..|||.   |.|.   .  ||..||     | .|.  ..   . .||| |..|...       . | ..   . ||.
tv..aqfhftewPdkdvpkhtssllkfike..vkadfG.qythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyaf

CYDCLLEysDKLLKEE
 | ..||  | | .. 
iygavle..dllwrnt
subfamily_PRL_pd Subfamily PRL 1196-1289 3.1e-06 21.3 In-house 49-135 (151) alignment 
Range on Protein: 1196-1289
Range on HMM: 49-135/151.0
TEKERTVLQFHYTAWPDRNVPAQAsHVLDFLRAINSANDKEEYGPIVVHCSAGVGRTGTIIALDIaleqlkLENKVDIKGIVTFLRKQRKQMVQ
.. |.. .. .  |. | .||...  | ..|. ....  .|    . ||| ||.||.  ..|| .      .|. .. .  | |.|..|.  . 
eklekegievldlafddGavPpee.vveeWlellkekfkeepkstvavhcvaGlGraPvlvalal......ieaGmkyedavefirekrrgain
V-set Immunoglobulin V-set domain 245-320 3.3e-06 17.9 Pfam-A 10-101 (114) alignment 
Range on Protein: 245-320
Range on HMM: 10-101/114.0
NSSVPVGQSIQLLVHFIggY--PLPTVTWYRLLG------IT-------NSNRVPITDPRAS--ASG-QYSLNLTITNSSLSDDGLYLLMINNT
  .| .|.|. | ...   .     ...||.         |.       ||.  .  . | .  ..| .....|||.| .|.| |.| ... ..
pvtvaeGgsvtLpCfys..ssensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsds
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1097-1305 4.2e-06 19.6 In-house 101-309 (346) alignment 
Range on Protein: 1097-1305
Range on HMM: 101-309/346.0
SHYINANFIKGYHDDKLYIAT--QGPKEETTDDFWRMVWeQRTVTIVMLTNLMESYKSKCHQYW-PSSGQCCY-GDIAV---RVDRNIELPHYTIrgfKV
 | .   |.    . || .|   |  .|   .||| |.. |  . .| |    .  |      .    |   | | . .   | |   .   |||   .|
vhlvvlyfvifqfehklivaqlpqmenesfvedfwymiy.qeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeyti...ev

FNERDTtekERTVLQF-HYTAWPDRNVPAQASHVLDFLRAINSANDKEEYGPIVVhCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRKQMV
. | ..   .  . |  |.. |   . | ..  .. ..  . | .. .. |  ||    | ||. ..|    |..||    . .|  |.  ...||   |
lpegns...dsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggv

QALCQYIFIHNAILEDI
... ||  |.  ... |
esfaqyasiyaivfdyi
0051082 (Phosphotyrosine protein) phosphatases II 1369-1564 5.5e-06 21.6 In-house 7-150 (151) alignment 
Range on Protein: 1369-1564
Range on HMM: 7-150/151.0
DGYWTPNLFIKSPSPTKeteeLFWRLIVQNECTHIINLSPADITTYSYIP-PDVGdrqlkfgpltvsvgrkqfntgfstrdisifneedsstLKLKYIQY
.  .  . .. |  |.      |..|. .. ...|.|| . . . | . . |. |                                     .....|..
nfsyvtgglyrsggpla....dflellkelgiktivnlrseeergycpeylpelg.....................................ievlhipi

QEML---LKQCFPRADKFIKFIQGclveaeschRGNHPILIHDDGSNGPVGIFATLAYCLQRAKKERIIDLLQSANHhylqcpGLIVNLQFYAYCYDCLL
  .    | ..|. . .|.....           .|.|.|.|  .  |  |... |  .|..   | ... ... ..      |..   | . ... .||
ldwpdpglplsfdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlkrp......gvvqpnqqflfqlfall
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1205-1303 9.6e-06 19.3 In-house 232-333 (347) alignment 
Range on Protein: 1205-1303
Range on HMM: 232-333/347.0
FHYTAWPDRNVPAQASHVLDFLRAINS---AN---DKEEYGPIVVHCSAGVGRTGTIIALDIALEQLKLENKVDIKGIVTFLRKQRkqmVQALCQYIFIH
.  |.|| .. | .  .|| ..||      .    . |   |.|| |  |. |. |..   | .||.   .  |   .   .| ||      .   ||  
yncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqr...agvftmsifyt

NAILE
 ||  
yaira