Gene PTPRD-44 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP100_AA protein Get Run
AqueP100_AA_5803-6081 phosphatase_domain Get Run
AqueP100_AA_6093-6358 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 5801-6102 2.9e-141 465.0 In-house 2-305 (305) alignment 
Range on Protein: 5801-6102
Range on HMM: 2-305/305.0
LPISLDDLAAHI--ATCYDSNAFEEQFKNLYDEEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLEcQTEYINANFVDGYSSSKKFITTQGPMKD
 .|.||||||.|  |..|.....|.|.|.||.||...||||...||| ||||.||..||.|||||. ..|. ...||||..||||...||.|..|||.|.
kiialddlaayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekesld.dsdyinasyvdgykrkkkyivaqgPlkn

TLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSF
|..||||||..|....|||||||.||||.|||||||.|..|.||||.|.|.|....|..|...|||.|.|.||...|.|..|||||.|||.|||..|||.
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

MSLYRRVINNWSLSKG-TILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVE
.||..|| .... .|| ..||||||||||||||||||||||..|||.|||.......||..||||||.|||| |||||| |.|.||.|.| ..|....|.
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvn

RLKKN
.|||.
klkkm
subfamily_PTPRD_pd Subfamily PTPRD 5802-6209 1.6e-134 444.6 In-house 4-416 (564) alignment 
Range on Protein: 5802-6209
Range on HMM: 4-416/564.0
PISLDDLAAHIATCY--DSNAFEEQFKNLYDE-EKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLeCQTEYINANFVDGYSSSKKFITTQGPMKD
||. ..|..|.|     ..  |||..|..  . . .... . ..||| ||..||. || .|..|...     ...||||.|.||| ..|..| ||||...
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfidgyrkrkayIAtqgPlae

TLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNStSeVKEFGPFNVILQNTQTYPDLFIRKLSItIQDESSDSHTLIQYQLTSWPDQGVPDYATSF
|. ||||..|...  .|||||||.| || || .|||.. .  ...| . | |...... |  ||....  . .||.|..  |.. |||||.|||..|||.
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatsl

MSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVER
..| |.| . ..  .| |.|||||||||||.||..|. ||..|.||.||| ..|..||.||  |||. .|| |.|.|.|| . ||.||...||.. ....
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

LKKNNRKTNSTKLEAQYNLLYQLTPDP-NDVDCKSAKAHASKNRSNNYLPPDKFIVALK-----ETDGYINASYLNSYRGKNAFILAQSPMENTVRDFWK
|.. ...|..|.||. .. |   .... ..  .   .    |||  | |. ..  | |.     |   |||||||..||.|.||| .|.|..||| |||.
LaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfwr

MIVDCKVSVIIMLCGEE
|... .| .|.||.. |
mvweeevkiivmltkle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 6102-6361 1.8e-110 363.9 In-house 15-287 (305) alignment 
Range on Protein: 6102-6361
Range on HMM: 15-287/305.0
NNRKTNSTKLEAQYNLLYQLtPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKETDG---YINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCK
..|......|||||..||.. ....||..|.|............|..|..|.. ||...   ||||||...|..|...|.||.|..|||.|||..||..|
earvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveek

VSVIIMLC----GEEDCCYQYWIDSMTY----DEFVVKVSSETNASGYIERKLKVSI---DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKS
||.|.||.    |..|.|.|||..|.|.    .||.|...||..||.|||||||.||   |||||.|||.|.||||..||.......|..|..|...||.
vstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

GKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQTTY
.|. |..||||..|.|.||...|.||||....|.|||||.|.|.||........||.||....|..|.......
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 5806-6085 1.7e-104 343.8 In-house 3-298 (301) alignment 
Range on Protein: 5806-6085
Range on HMM: 3-298/301.0
DDLAAHIATCYdSNAFEEQFKNLYD-EEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHL-ECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDF
.|| .| |... || ||||.|.|.. |.|.|.|| |.||||||| |||||||||||||.| ..|  ||.|||||...||||..|||| .||||| |||||
edlgthvaakh.snkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdf

WRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESS--------------DSHTLIQYQLTSWPDQ
|||||||.||||||.|.|||| ||||.||||||. | .|||||.| |.|.|.|||  ||.|...||| |.              .|....|.|.|.||..
WrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqd

GV-PDYATSFMSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKT
|| ....|  ...   .. ... ..| ..||||..|.|.||...|.|.|||.| | |||. ......|......|. |.|| ...|.. . . . .|
GvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 6098-6359 2.2e-101 333.5 In-house 4-295 (301) alignment 
Range on Protein: 6098-6359
Range on HMM: 4-295/301.0
RLKKNNRKTNSTKLEAQYNLLYQLTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKET-----DGYINASYLNSYRGKNAFILAQSPMENTVRDFWK
 |.... ...|.|.|.||. |.. ......| .................. ...|.. |..       ||||||...|. |..|| ||.||..|..|||.
dlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWr

MIVDCKVSVIIMLCGEEDC----CYQYWIDSMTY----DEFVVKVSSET-----------------NASGYIERKLKVSIDKESRSVLQLQVTDWPQDGV
.|.. |.. |.|.......    |.||| .| .      .| |....|.                    ||||||.||. ||.|..||||||||||||||
liwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGv

VREPSTILKIIDEVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
|||| |.|..||.|  .|..  .||||||||||||||||||||||.|||| |||||||||||||.|||||||.||||||||||||.| ||| 
vreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
0050432 (Phosphotyrosine protein) phosphatases II 5799-6086 7.9e-90 296.6 In-house 22-305 (308) alignment 
Range on Protein: 5799-6086
Range on HMM: 22-305/308.0
LTLPISLDDLAAHIATCYDSNAFEEQFKNLYDEEKPCD--VGKSNENKALNRLKNITVYDDNRIILtplshlECQTEYINANFVDGY--SSSKKFITTQG
 .|..|..||. ..   .|.  .||.|. |..   ...  |..  ||| .|| |.|  || .|..|      .  . ||||..||||   ...||| |||
sslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqg

PMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTS-EVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESsDSHTLIQYQLTSWPDQGVPD
|...|. ||||..|...   ||||||| | |. || ||||...  ...|.|.| | | ......|  .|.| .|  ... .|.|. ... |.|||.|||.
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPp

YATSFMSLYRRVINNWslSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTE
...........| .    ..|.|.|||||||||||.|||.|..||| .||. ||. ..|..||.||. |||...|||||..|||| . . .| 
speilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 5803-6116 5.1e-88 290.2 In-house 2-316 (318) alignment 
Range on Protein: 5803-6116
Range on HMM: 2-316/318.0
ISLDDLAAHIATCYDS--NAFEEQFKNLYDEEKPCDVGKSN--ENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKD
||..||. |..    |    ..|....|  .|.     ||.   ||| ||  ||. ||. |. |..|.  | ...|||||..||| ..|..| .|.|. .
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmleg.eegsDyinanyidGyrrkkayiaaqaPlpe

TLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSevKEFGPFNVILQNTQTYPDLFIRKLSITIqDESSDSHTLIQYQLTSWPDQGVPDYATSF
|. ||||..|.     |||||...| || |. .|||.. |  ...|   | |... .. |. .|....|  .|...| .  ||. |||||.|||. ..|.
tieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs..rsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgasl

MSLYRRVINNW-SLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVE
..| |.| .   . ..|.|.|||||||||||||||||| ||..|.|..||. ..|..||.||  |||  ||| |..|.||| ...|.||.  .. .  ..
ldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrir

RLKKNNRKTNSTKLEAQYN
.|.... ..  |...|...
elreqdpesgttemdaefq
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 5816-6080 7.3e-88 289.2 In-house 17-283 (290) alignment 
Range on Protein: 5816-6080
Range on HMM: 17-283/290.0
YDSNAFEEQFKNLYDEEKP--CDVGKSNENKALNRLKNITVYDDNRIILTPLS-HLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERP
   . |..||| |   |..    || ...|| ||| .|| |||||||.| |.| | .|. ||||| ...||. .|..| ||||...||||||.|||||. 
kgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekv

VSIVMLTKLKEGGKSKCRQYWPNSTSEVkeFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQG-VPDYATSFMSLYRRVINNWSL
  |||||. .| || ||.||||.| ..   .|.|.. |.| .|. .  .|||... .... ......|||.|.|...| |....|. ....... ...  
tiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkr

SKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEI
 .. |.||||..|||..||.|........|.| |.|.  .....|.|....||. .|| .... .|. .
gntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
0051299 (Phosphotyrosine protein) phosphatases II 5817-6080 3.4e-87 287.8 In-house 21-286 (288) alignment 
Range on Protein: 5817-6080
Range on HMM: 21-286/288.0
DSNAFEEQFKNLYDEE--KPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVS
. . ..|.|. |..     .. ...  ||.  || ..|  ||..|..|..|.  .  . ||||...||| ...||| ||||...|. ||||..|...   
gltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrv

IVMLTKLKEGGKSKCRQYWPNstSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQD---ESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSL
||||||| | |. || ||||.  ......|.. | | ......|  .|.| .|  |    .. |.| .... |.|||.||||.........|.|..  . 
IvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalas

SKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEI
..|...|||||||||||.|||.|..||| .||..||. ..|.|||.||. |||...||.|...|||| .
gggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 5821-6087 7.5e-87 286.6 In-house 2-281 (284) alignment 
Range on Protein: 5821-6087
Range on HMM: 2-281/284.0
FEEQFKNLYDEEK----PCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLECQTEYINANFVDGY-----SSSKKFITTQGPMKDTLVDFWRLIWQER
.||.|. |.        ...|..  ||. .|| |.| .||..|..|..|..    ..||||..||||      ..|||| ||||...|. ||||..|...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

PVSIVMLTKLKEGGKSKCRQYWPNStSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWS-
   |||||.| | |. || ||||.. .||...|.| | | ......|  .|.|..|  . .. |.|..... |||||.|||..........| | .  . 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-LSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEK---VVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEI
  ..|.|.|||||||||||.|||.|..||| .||.   .||. ..|.|||.||. |||.|.||.|...|||| . ...| .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0036941 (Phosphotyrosine protein) phosphatases II 5820-6091 1.1e-85 282.9 In-house 14-288 (297) alignment 
Range on Protein: 5820-6091
Range on HMM: 14-288/297.0
AFEEQFKNLYDEE--KPCDVGKSNENKALNRLKNITVYDDNRIILtplSHleCQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVM
 ....|. |..     ...|... ||. .|| |.|  ||..|..|   ..    . ||||..||||. ..||| ||||...|. ||||..|...  .|||
lllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd..egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

LTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQT--YPDLFIRKLSITIQdESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSL--SK
||.| | |. || ||||. . |....|.| | |.....  ..|  .|.| .|   ....|.|. ... |.||| |||....|.......| .  .|  |.
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

GTILVHCSAGVGRTGVFIAVDIALEQAK---KEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIEN
| .||||||||||.|.|||.|..|.| .   ||. |||  .|. ||.||. .||.|.||.||..|||| . ...| .|. .
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 5818-6086 1.3e-85 281.8 In-house 19-284 (287) alignment 
Range on Protein: 5818-6086
Range on HMM: 19-284/287.0
SNAFEEQFKNLYD-EEKPCD--VGKSNENKALNRLKNITVYDDNRIILTplshlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVS
.. |..||. | . .... .  .. ...|| .|||..| |.|..|..|      ... .|||| |.|||...|.|| ...|| .|...||.||.....  
negfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvta

IVMLTKLKEGGKSKCRQYWPNSTSevKEFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQG-VPDYATSFMSLYRRVINNWSLSK
||||...||  ...| ||||...|    .|..|. | | ... .  .||| .. .....| ... |||.|.|...| |....|... . ... ..   ..
ivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgn

GTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTE
..|.||||..|||...|.|........|.| |.|.  .... |.|....||  .|| |. |..|| . ...| 
tsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
0039614 (Phosphotyrosine protein) phosphatases II 5801-6085 2.6e-85 281.8 In-house 14-294 (297) alignment 
Range on Protein: 5801-6085
Range on HMM: 14-294/297.0
LPISLDDLAAHIATCYDSNAFEEQFKNLYDEEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLECQTEYINANFVDGYSS-SKKFITTQGPMKDT
 |.|  ||. .. .. ... ....|..|..   .. .... ||| .|| |.|  ||..|..|.|. .    . ||||..||||.  ..||| ||||...|
iplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

LVDFWRLIWQERPVSIVMLTKLKEGGKsKCRQYWPNSTSevkEFGPFNVILQNTQTYPDLFIRKLSITIQDESsdsHTLIQYQLTSWPDQGVPDYATSFM
. ||||..|...  .|||||||.| |. || ||||....   ..|.| | | ....... ..|.|..|  .||   .|. ..| |.||| |||.......
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges...rtvthfqytgwpdhgvppslelll

SLYRRVINNWSL--SKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKT
.... | .  .   ..| .||||||||||||.||| ...||| .||. ||.  .|..||.||...||...|| ||.||||| . ...|
eflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0040438 (Phosphotyrosine protein) phosphatases II 5819-6096 4.3e-85 281.1 In-house 18-292 (317) alignment 
Range on Protein: 5819-6096
Range on HMM: 18-292/317.0
NAFEEQFKNLYDE--EkPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIV
.|..|.|..|..   . ...|..  ||| .|| ..|  ||..|..|.||.     . ||||..|||.. ..||| ||||...|. ||||..|...  .||
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLTKLKEGGKSKCRQYWPNstSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQdESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTI
|||.|.| |. || ||||.   |....|.| | |........  .|.| ..   ..|.|.|. ... |.|||.|||.. ... .. ..| .. . ..| .
mLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpv

LVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAV
||||||||||||.|||....||| .||. ||.  .|..||.||...||...|| ||.||||| . .. | .|. .. |..
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 5802-6115 1.8e-84 278.6 In-house 4-318 (319) alignment 
Range on Protein: 5802-6115
Range on HMM: 4-318/319.0
PISLDDLAAHIATCYD--SNAFEEQFKNLYDE-EKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKD
.| ...|. .. .  .  .. .|..||.|    ..  |  . .|||  || .||  ||  |..|..|     ...||||.|.|||   .||| ||.|...
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgyqerekfiatqaPlen

TLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNStsEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSF
|. ||||..|.|.   .||||||.| .| |...|||.   ...|.| . | |.. .   |. ||||.. .. .  .. .. ..| |.|||..||..||| 
tiedfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsl

MSLYRRVINNWSL-SKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVE
. |..|. . ..  ..| | ||||||||||| ||..|..||. |.| |.|.  .|.||| ||  |||  .|| |...|||| . .|.||| ...    . 
ldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlk

RLKKNNRKTNSTKLEAQY
.|.... .|  |.|| ..
qlaekvadtgetgleref
subfamily_PTPRK_pd Subfamily PTPRK 5804-6115 1.4e-83 275.3 In-house 5-312 (314) alignment 
Range on Protein: 5804-6115
Range on HMM: 5-312/314.0
SLDDLAAHIATCY--DSNAFEEQFKNLYDEekpCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKDTLV
  .||  .||.    ..  | |....|..     |. | .||.. || ..|  ||  |..|...   . ...||||...|.|  ...|| ||||...|. 
rvadllqsiallkraegygfkeeyeslfeg...wdaakkdenreknrsgdilaydrsrvflitidg.dpssdyinaalidsykrpaafivtqgPlqetvk

DFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEvkeFGPFNVILQNTQTYPDLFIRKLSITI-QDESSDSHTLIQYQLTSWPDQGVPDYATSFMS
|||||...|.  ||||||.|.| |. || .|||. |.    .|...| | .|..  .| .| ....  .   .. ... |.| ..||| .|| .||....
dfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk

LYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVERLK
| ||| .    ..| |.|||||| ||||.|||.|| |. ...|.|||.  .|  ||.... ||.  .|| |..|..||  .||.| ||. ..  .    .
lvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesi

KNNRKTNSTKLEAQY
. . .|||..|. ..
rldpqtnssqlkeef
DSPc_SM00195 5821-6080 8.6e-83 273.0 In-house 2-262 (263) alignment 
Range on Protein: 5821-6080
Range on HMM: 2-262/263.0
FEEQFKNLYDEE--KPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLeCQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVML
..|.|..| ...  |... .. ..||. || ||| .||..|..|..  .   ...|||||...|....||.| ||||...|. ||||..|.|.   ||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYP-DLFIRKLSITIQDEsSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTIL
|. .| || || .|||..  . ..|| ..| |....... .. .|.|..| ... ...... ||| ..|||.|||| ..|...|.| | .  | |.|.|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEI
|||||||||||.|...||.|.. ..|| |||  ||..||.||..|||.|.||||...|.|| |
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 5821-6080 8.6e-83 273.0 In-house 2-262 (263) alignment 
Range on Protein: 5821-6080
Range on HMM: 2-262/263.0
FEEQFKNLYDEE--KPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLeCQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVML
..|.|..| ...  |... .. ..||. || ||| .||..|..|..  .   ...|||||...|....||.| ||||...|. ||||..|.|.   ||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYP-DLFIRKLSITIQDEsSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTIL
|. .| || || .|||..  . ..|| ..| |....... .. .|.|..| ... ...... ||| ..|||.|||| ..|...|.| | .  | |.|.|.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEI
|||||||||||.|...||.|.. ..|| |||  ||..||.||..|||.|.||||...|.|| |
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRB_pd Subfamily PTPRB 5801-6080 1.8e-82 271.7 In-house 5-285 (293) alignment 
Range on Protein: 5801-6080
Range on HMM: 5-285/293.0
LPISLDDLAAHIATCY-DSN-AFEEQFKNLY--DEEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPM
 ||.|.....|...   ||.  | |....|   .... ... ....|.| || .||  || .|. |..|.. | ...|||||...||.| ..||.||||.
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkd.esgsDYinanyipgynsprefiatqGPl

KDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVkEFGPFNVILQNTQTYPDLFIRKLSITIqdeSSDSHTLIQYQLTSWPDQGVPDYAT
 .|. ||||..|...   |||||.| |.|| || .|||. ...|  .|  .| |...... |  ||.|.|.    ....... ||. ||||| |||. ..
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektk

SFMSLYRRVINNW--SLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEI
..... |.| ..   . ||. |.|||||||||||.|||.|  |.. ..| .|||.||| .||..|. .||. .||.|.|...|. .
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0047943 (Phosphotyrosine protein) phosphatases II 5817-6078 3.8e-82 271.1 In-house 10-270 (273) alignment 
Range on Protein: 5817-6078
Range on HMM: 10-270/273.0
DSNAFEEQFKNLYDEE--KPCDVGKSNENKALNRLKNITVYDDNRIILtplshLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVS
... ..|.|. |..     .. |..  ||| .|| |.|  ||..|..|      .  . ||||..|||| ...||| ||||...|. ||||..|...   
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLTKLKEGGKSKCRQYWPNSTSE-VKEFGPFNVILQNTQTYPDLFIRKLSITIQDESSdSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSL--
|||||.| | |. || ||||..  | ....|.| | | ...|..|  .|.| .|  . .  |.| .... |.|||.|||.. .|...... | .  .   
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealp

SKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
|.|...|||||||||||.|||.|..|.| .||. ||.  .|..||.||. |||...||.||..||||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 5818-6079 4.8e-82 271.4 In-house 26-303 (307) alignment 
Range on Protein: 5818-6079
Range on HMM: 26-303/307.0
SNAFEEQFKNLYDEEK----PCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLECQTEYINANFV--------DGYSSSKKFITTQGPMKDTLVDFWR
 . ....|. |.....    ....... ||| .|| |.|  ||..|..|..|..    . ||||..|        ||| ...||| ||||...|. ||||
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

LIWQERPVSIVMLTKLKEGGKSKCRQYWPNStSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRV
..|...   |||||.|.| |. || ||||.. .|....|.| | | ........ .|.| .|  |... |.|..... |.|||.|||..  .. .....|
mlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

INNWSL--SKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKV---VDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEE
 .  .   ..| .||||||||||||.||| ...|.| .||..   ||.  .|..||.||...||...|| ||..|||| 
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 5802-6115 3.8e-81 267.4 In-house 5-314 (315) alignment 
Range on Protein: 5802-6115
Range on HMM: 5-314/315.0
PISLDDLAAHIATCYD--SNAFEEQFKNLYD-EEKPCDVGKSNENKALNRLKNITVYDDNRIILtPLSHLECQTEYINANFVDGYSSSKKFITTQGPMKD
|| ||.| ...|       | |.......   . .| || |  |||  ||  ||  ||  |. | ||   . ...|.||||.|||.  ...|..|||   
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvql.pllendphsdyvnanfidGynkkrryiaaqgpnva

TLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNStsEVkEFGPFNVILQNTQTYPDLFIRKLSITIQDEssdSHTLIQYQLTSWPDQGVPDYATSF
.. |||||...|    |||||.| || |.|. .|||.   .|  .|.. | ... . . .. .| ||.. .|.    ....|...||||| ||| |....
svkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kv.iyGkitvtrkseevnteytvrtlsvvfgdn...irevvqlhytswpdmgvpkytipl

MSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVER
| |.|.|      | |.|.||||||||||| ||..|  |.||. |...|.  .....||.|.||||...|| |..||||| ..|| | |  . |    . 
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryds

LKKNNRKTNSTKLEAQY
|   .  | || |. |.
llapspdtgstllqeqf
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 5819-6087 4.8e-80 264.0 In-house 27-297 (298) alignment 
Range on Protein: 5819-6087
Range on HMM: 27-297/298.0
NAFEEQFKNLYDEEK-----PCDVGKSNENKALNRLKNITVYDDNRIILTPLShLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPV
  ....|..|   ..       .|....|||  ||  .|  .|  |..|.  .  . ...|||| |...|. .. ||.||.|.. |..||||....|   
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked.adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedig

SIVMLTKLKEGGKSKCRQYWPNSTSEvkEFGPFNVILQNTQTYPDLFIRKLSITIQDESsDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINnWSLSK
.|||||.|.| .| |. .|||.. .|  ..| ..| |...... || .||| .. ..|. ..... | . |||||.||| .||| . | |.|   .    
tiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqa

G--TILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEI
|   ..|.|||||||.| |||.|  ||..|||.|||.  .|..||..|...||. .|| |...| || . ....||
gnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Ptp69D_pd Subfamily Ptp69D 5803-6099 3e-79 261.3 In-house 4-305 (307) alignment 
Range on Protein: 5803-6099
Range on HMM: 4-305/307.0
ISLDDLAAHIATCYDSN--AFEEQFKNLY--DEEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLEcQTEYINANFVDGYSSSKKFITTQGPMKD
|..|||.  . .        ... ...|     .| . |.. .||.  || ..|. .|..|..|...   | ...||||.|. ||  .||||. |.|.  
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke.dsdYinasfikgykekkkfiaaqdPvea

TLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNStsEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESS----DSHTLIQYQLTSWPDQGVPDY
|. ||||.|..     ||||..|.|  . || .|||.   . ...|  .| | .... .|  ||.|... ..|.|    ||. ..||. |.|.|  ||. 
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

ATSFMSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSL
|.. . | ..| .  .|... |.|||||||||.|.|.|.|. |.| |.|. |||  .|  ||.||  .||||.|| ||. |||. .  |.|.. ..... 
argllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

AVERL
|.|||
aierl
0043336 (Phosphotyrosine protein) phosphatases II 5819-6078 1.3e-78 259.6 In-house 20-275 (278) alignment 
Range on Protein: 5819-6078
Range on HMM: 20-275/278.0
NAFEEQFKNLYDEE-KPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVM
 .....|..|..    ....... ||| .|| |.|  || .|..|..|.  .  . ||||..||||. ..||| ||||...|. ||||..|...  .|||
tllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg.dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivm

LTKLKEGGKSKCRQYWPnstSEVKEFGPFNVILQNTQTYPDLFIRKLSITIqDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTIL
||.|.| |. || ||||   ......|.| | |.......|  .|.| .|    .. |.|  .|. ..|||.|||.  .........|..  . |.| .|
LtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvl

VHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
|||||||||||.|||....|||..||. ||.  .|..||.||...||...|| ||..||||
VHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 5817-6078 1.9e-78 258.4 In-house 19-277 (288) alignment 
Range on Protein: 5817-6078
Range on HMM: 19-277/288.0
DSNAFEEQFKNL--YDEEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVS
. . |.|....|   ...|  ..|.  .|.  || .||  || .|. |. | . | ...||||...||. ..||.|.||||. ||. |||.|.....   
nrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkklee.eagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

IVMLTKLKEGGKSKCRQYWPNSTsEVKEFGPFNVILQNTQTYPDLFIRKLSITiqdESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKG
|||||.| ||||.|| .|||..  . |..| ..|.|.....  |   ||| .     . .  .. ||| ..|||.|||. .. .. | | | .. .   |
ivmltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtg

TILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
 |.|||||||||||.|||.| .... ..|...|.||.|..||.||. .|| | || |....||.
piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPRG_pd Subfamily PTPRG 5804-6090 3.8e-78 258.1 In-house 2-297 (563) alignment 
Range on Protein: 5804-6090
Range on HMM: 2-297/563.0
SLDDLAAHIATCYDSN--AFEEQFK----NLYDEEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLECQTEYINANFVDGYSSSKKFITTQGPMK
 ....| |.| .. ..   |.|.|.    .  ... ...  . .|||  ||  ||. ||  |. |.||.  . . .|||||..|||  ||.||.||||.|
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

DTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNstSEVKEFGPFNVILQNTQTYP-----DLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVP
||. ||||.||...   |||.|.|.| |. || .|||.   |....| ..| |.....        | |..| .  ...  . .. .||. |.|||.|||
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

DYATSFMSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIE
....  ..  ..         | |.|||||||||||..|..|  |.| ..|..|.. |.. ..| ||  .||. .||.|||||||| |  ..||.  |
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellae
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 6096-6359 4.6e-78 257.1 In-house 7-280 (287) alignment 
Range on Protein: 6096-6359
Range on HMM: 7-280/287.0
VERLKKNNRKTNSTKLEAQYNLLYQLTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKE-TDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMI
. .. .........  . |. .| |.| ....|  . |.    |||... |.||.. | ||.  . ||||.....|. |.|||.|.||| ||.|.|||.|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkli

VDCKVSVIIMLCG----EEDCCYQYWIDSM--TYDEFVVKVSSETNASGYIERKLKVSIDK---ESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQ
 | .|..|.|||     .|. ||||| ..   .. |. ... .|.  .|||||||.|  ..   . ..| | |.|.|.. | | || ||| .|.|   .|
ddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

KSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
.   ....|||||||| ||...|.. .....|. |||.||||| |  |  |||.. | |||. |.|.|  ||..
rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 5803-6156 6.7e-77 253.7 In-house 2-354 (515) alignment 
Range on Protein: 5803-6156
Range on HMM: 2-354/515.0
ISLDDLAAHIATCYDSNAFEEQFKNLYDE-EKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKDTLV
. | .. | ..       | |.|..|      |  | . . |   || |||  || .|..|  .   . . .|.|| .. .. . | .|..||| | .. 
lplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevind.nPhsdyfnasyipsfdndkayiasqgPnkasvd

DFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDEssdSHTLIQYQLTSWPDQGVPDYATSFMSL
|||||..||..  |.|.|||||| |.|| .|||.  ..  .|| ..| |  ...  .  .||| .. .|.   |.|. |...| |||.|||  ..|.. |
dfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllkl

YRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVERLKK
 . |  . .  . ....|||||||||||.|..|  . .||. ..||.  .|. .||.|...||  .|| |...|.||..   .| ||.  ..  .. |. 
ikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhs

NNRKTNSTKLEAQYNLLYQLTPDPNDVDCKSAKAH--ASKNRSNNYLPPDKFIVALK
       .|.  ... |  |.|||   ...|....    |||  | || ..  | | 
sgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvild
subfamily_PTPRA_pd Subfamily PTPRA 5802-6113 8.2e-77 253.3 In-house 13-328 (330) alignment 
Range on Protein: 5802-6113
Range on HMM: 13-328/330.0
PISLDDLAAHI--ATCYDSNAFEEQFKNLYD--EEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLECqTEYINANFVDGYSSSKKFITTQGPMK
|. ...|   |   .. |.. | |.|..|     .  ... . .|||  ||. ||  || .|.||....  |. ..|||| |.|||   .|||..||| .
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvee.sdyinasfidGykekdkfiaaqGPke

DTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSevKEFGPFNVILQNTQTYPDLFIRKLSITI-QDES--SDSHTLIQYQLTSWPDQGVPDY
.|. ||||.||. .  .|||||.|||  ..|| ||||.  .    .|  .| .....   |. .||. ..   |..   .|  . |. .||||| |||  
etvedfwrmiweqksativmltelkerkeekcaqywPdeGl..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

ATSFMSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSL
.   ..| ..| .    | |.| ||||||||||| ||..|  ||. | |..||. ..|.|||.|| .|||.. || |.. .|||  . | ||. .     
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslek

AVERLKKNNRKTNSTKLEA
 ...|...  .|. . || 
hlqklynkitgtdkiglee
Y_phosphatase Protein-tyrosine phosphatase 5843-6078 9.5e-77 252.9 Pfam-A 1-235 (235) alignment 
Range on Protein: 5843-6078
Range on HMM: 1-235/235.0
NKALNRLKNITVYDDNRIILtplSHLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKE
||  || |.|..||..|. |   .. | ...|||||.|.||...|||| ||||.|.|. ||||..|||.  .|||||.|.| |. || ||||....| ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGPFNVILQ-NTQ-TYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQA
.| ..| |. ...    .  .|||... ..|.|..... |...|.|||.|||. ..|...| |.| .. . ..| ..|||||||||||.|.|.||.|||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
..|. ||.  ||..||.||..|||||.|| ||..|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 5843-6078 9.5e-77 252.9 In-house 1-235 (235) alignment 
Range on Protein: 5843-6078
Range on HMM: 1-235/235.0
NKALNRLKNITVYDDNRIILtplSHLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKE
||  || |.|..||..|. |   .. | ...|||||.|.||...|||| ||||.|.|. ||||..|||.  .|||||.|.| |. || ||||....| ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGPFNVILQ-NTQ-TYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQA
.| ..| |. ...    .  .|||... ..|.|..... |...|.|||.|||. ..|...| |.| .. . ..| ..|||||||||||.|.|.||.|||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
..|. ||.  ||..||.||..|||||.|| ||..|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 6087-6359 1.6e-75 248.6 In-house 2-285 (290) alignment 
Range on Protein: 6087-6359
Range on HMM: 2-285/290.0
IPIENYSLAVErlkkNNRKTNSTKLEAQYNLLYQlTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALK----ETD---GYINASYLNSYRGKNAFILA
||.....  |.    |..... .. ..|.. | . .  .. |  . ..    .||..|....| . . |.    . |    ||||.|.. |. |...|..
ipvdkfgefva....nghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiat

QSPMENTVRDFWKMIVDCKVSVIIMLCG----EEDCCYQYWIDS--MTYDEFVVKVSSETNASGYIERKLKVSIDKE---SRSVLQLQVTDWPQDGVVRE
|.|..||..||||.|.. ||..|.||.     ... |.||| ||   .|.|| .|...|.. ..||||||.|  ...   ..|| |.|.| |...| | .
qgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtn

PSTILKIIDEVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
|.||| .| |. ..|.   ....||||||||.||.|.|.. .....|. |||.||||| | .|  ||| ..| .||  |...|  ||..
pqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0050432 (Phosphotyrosine protein) phosphatases II 6096-6359 1.5e-74 246.5 In-house 29-301 (308) alignment 
Range on Protein: 6096-6359
Range on HMM: 29-301/308.0
VERLKKNNRKTNSTKLEAQYNLLYQLTPdPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKETDGYINASYLNSY--RGKNAFILAQSPMENTVRDFWKM
 . ||. ........||.... |....| ... .. . ... .|||. ..|| |.  | |.|...|||||| . |  . ...||..|.|..||| |||.|
ldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrm

IVDCKVSVIIMLCGEEDC----CYQYWI-----DSMTYDEFVVKVSSETNASGYIERKLKVSI--DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVR
. . .|.||.||. ...     |.|||      .|..|. |.|.. ||.. ..|. |.|...   |.||| | ... |.|| .||  .|. .|.....||
vweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr

EKQksgKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
...   ..||.|||||. |.|.|... . ..||| ..|| ||||.. | ||. .||...|.|||  .|...  ||..
ksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 5802-6116 5.3e-74 243.9 In-house 2-313 (315) alignment 
Range on Protein: 5802-6116
Range on HMM: 2-313/315.0
PISLDDLAAHIATCYDSNAFEEQFKNLYDEE-KPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKDTL
|| . .. | .     .  | |.|..| | .  .  |.. ..|   || |||  .| .|..|  .   . . .|||| .. .. . | .|..||| | ..
pipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevidd.sPdsdyinasyiksvdddkayiasqgPlkasv

VDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLsitIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMS
 ||||...||.. .|||.||..|| | |||||||.  ..  ||| ..| | ....  |  .|||   .  .| .|.|. |.|.| |||.||.  ..|.. 
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllk

LYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVERLK
| . |  .    . ..|||||||||||||.|..|  ..|.|....||.  .|. ||..|...||. ..| |..||.||..   .| |.. ...  .. |.
likevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

KNNRKTNSTKLEAQYN
 .   .  .|.  ...
tsvdgsgrskmtkefe
0040439 (Phosphotyrosine protein) phosphatases II 5834-6079 3.2e-73 241.7 In-house 2-245 (249) alignment 
Range on Protein: 5834-6079
Range on HMM: 2-245/249.0
PCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLECQTeYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYW
...|..  ||| .|| ..|  || .|..|..|. |..   ||||...||| ....|| ||||...|. ||||..|...  .|||||.|.| |. || |||
eysvallpenkdknrypdilpydhsrvklsilpglflsd.yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PNstSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQdESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSL--SKGTILVHCSAGVGRTGVFI
|.  ....|.| | | | ......|. .|.| .|   . ..|.|  ..| |.|||.|||..  ........| .  .   ..| .||||||||||||.||
pl..ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

AVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEE
| ...||| .||. ||.  .|. ||.||...||...|| ||..|||| 
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 5836-6092 3.2e-73 241.0 In-house 2-248 (250) alignment 
Range on Protein: 5836-6092
Range on HMM: 2-248/250.0
DVGKSNENKALNRLKNITVYDDNRIILTPLShLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSkCRQYWPN
.|.|  .||  ||  .|  .|  |..| . .  . ...|||| |..||. .| ||.||||...|..||||....|   .|||||.||| .|  . |||| 
svakkpqnkeknryadiialdssrvvLekek.gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

STSevKEFGPFNVILQNTQTYPDLFIRKLSITIQDESSdSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSL-SKGTILVHCSAGVGRTGVFIAVD
 ..  ...|   | | ..... |. .||| .. . ... . .. |.. ..|||.|||..||. . | ..|  .     .. ..|.|||||||.| |||.|
eka..ekyGdvtvsllskeefadytkrklklskakkad.erivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid

IALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICgkteipIENY
  ||..|||||||.  ....||..|...|.||.|| |.. ..|. . .      .|.|
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds......vedy
0045098 (Phosphotyrosine protein) phosphatases II 5833-6083 1.3e-72 239.9 In-house 23-275 (278) alignment 
Range on Protein: 5833-6083
Range on HMM: 23-275/278.0
KPCDVGKSNENKALNRLKNITVYDDNRIIltplshlecqtEYINANFVDGYssSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQY
  . ..   .|...|| |.|  || .|..           .||||...|||  .|||| ||||...|. ||||..|...  .|||||.|.|.|. || ||
seitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPNstSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQ---DESSDSHTLIQYQLTSWPDQGVPDYA--TSFMSLYRRVINNWSL-------------SKG
||.  ......|.| | |.......|  .|.| .|     .|.  |... ......||| |||..   .|| .|.... .  .|             |.|
wpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

TILVHCSAGVGRTGVFIAVDIALEQAkkEKVVDIAGIVNRLRQQRMK-MVQSLDQYLFLHDALLEEIICG
..||||||||||||...|... ||.   |..||.  .|. ||.||.  .||.|.|| ||...||| . .|
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0051299 (Phosphotyrosine protein) phosphatases II 6084-6357 2.1e-72 239.3 In-house 2-286 (288) alignment 
Range on Protein: 6084-6357
Range on HMM: 2-286/288.0
KTEIPIENYSLAVERLKknnrKTNSTKLEAQYNLLYQLTPDpNDVDCKSAKAHASKNRSNNYLPPDKFIVALK-----ETDGYINASYLNSYRGKNAFIL
.|||..|..  .|..|.    ... |.|..... |..|.|| ... . . ... .|||. ..|| |.  | |.     |...||||||.. |. |..||.
dteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

AQSPMENTVRDFWKMIVDCKVSVIIMLCGEEDC----CYQYWI--DSMTYDEFVVKVSSETNASGYIERKLKVS------IDKESRSVLQLQVTDWPQDG
.| |..||| |||.|. . .|.||.||.....     |.|||   .|.||....|.  ||.  ..|. |.|.|.       |.||| | ....|.|| .|
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

VVREPSTILKIIDEVREKQKsGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYL
|   |. .|... .||....  ..||||||||. |.|.|... . ..||| ..||.|||... | ||. .||...|.|||  .|...  ||
vpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0042113 (Phosphotyrosine protein) phosphatases II 5835-6078 1.1e-71 236.4 In-house 1-241 (245) alignment 
Range on Protein: 5835-6078
Range on HMM: 1-241/245.0
CDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWP
..|..  ||| .|| ..|  ||..|..|.| .. .  . ||||..||||  ..||| ||||...|. ||||..|...  .|||||.. | |. || ||||
ysvallpenkdknrysdilpydhtrvklspdgg.dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

NstSEVKEFGPFNVILQNTQTYPDLFIRKLSITIqDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWS-LSKGTILVHCSAGVGRTGVFIAV
.  .|....| | | | ......|. .|.|..|  . .. |.. |.|. ..|||.||||.  .. .....| .  .  |.|..||||||||||||.|||.
l..gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

DIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
...|||..||. |..  .| .||.||...||...|| ||..||||
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 5817-6080 2.1e-71 235.3 In-house 11-276 (281) alignment 
Range on Protein: 5817-6080
Range on HMM: 11-276/281.0
DS--NAFEEQFKNLYD--EEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERP
..  . | |....|..   ...    |..||.  || .||. ||  |. .|| .. . .|.|||||||.||.. |..|.||||. ..||.||...|... 
qndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpnee.nkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkv

VSIVMLTKLKEGGKSKCRQYWPNSTSEVKeFGPFNVILQNTQTYPDLFIRKLSItiQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSlYRRVINNWSLS
  |||.|.  |.|| || .|||. .||.| .| . |  ..... .    ||...  . ||... .. | . |.|||.|||. .. ... .|. ... . .
saivmvtreieagklkChrYWPddnselk.ygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkelle.frkevlkltek

K--GTILVHCSAGVGRTGVFIAVDIALEQAKKE-KVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEI
|   ....||||||||||..||.| .......| . .|.  .|. ||..|. |||.. || |.. |.|. .
ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 5817-6088 2.7e-70 231.5 In-house 7-274 (283) alignment 
Range on Protein: 5817-6088
Range on HMM: 7-274/283.0
DSNAFEEQFKNLYDEEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlecqtEYINANFVD---GYSSSKKFITTQGPMKDTLVDFWRLIWQERPV
. ..| |..|.|   ....|.  ..|||  || ..| ..| .|. | ..|.     .|||| |.     |  .||.| .|.|...| ||||.....|. .
nnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

SIVMLTKLKEGGKSKCRQYWPNSTSEvkEFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSlYRRVINNW-SLS
.|||||||.|. . || ||||.  ||  ..|.| | |..  |   . |..| .  .  . ..  |  ||.  | . |      |..  . .|| .     
aivmltklqedlrikCsqyWPkrGse..dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvislqtesk

KGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIP
|| |.||||.|.|||.||||.  ....|. | |||.  .|. .|.||| .||.|||| ..|.. ||. .|| |.| 
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 5841-6098 4.8e-70 231.4 In-house 59-309 (319) alignment 
Range on Protein: 5841-6098
Range on HMM: 59-309/319.0
NENKALNRLKNITVYDDNRIILTPLSHLECqTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTklkeggKSKCRQYWPNSTSEV
..||  ||. ||  .| |.. | .|   |  ..|||| ||.|| . .|.|..|||...|| ||||.||. .  .||.||      | || ||||. . . 
dqnkdknriinilafdknvvklerliGeef.sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

KefGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRV--INNWSLSKGTILVHCSAGVGRTGVFIAVDIALE
.  . |.| ..  .   .  .|.. .. . .  |   . |. .  |||.|||||.. .| | ..|  ...    .  |.||||||||||||.|..|. |.
e..erfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlld

QAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVER
. |.|| ||.  .|. ||||| ..||.| || |.. ||||| . |.... . ..   .|.
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpaylee
0046845 (Phosphotyrosine protein) phosphatases II 6111-6359 1e-69 230.4 In-house 2-276 (284) alignment 
Range on Protein: 6111-6359
Range on HMM: 2-276/284.0
LEAQYNLLYQLTPDPN-DVDCKSAKAHASKNRSNNYLPPDKFIVALK------ETDGYINASYLNSY-----RGKNAFILAQSPMENTVRDFWKMIVDCK
||...  |..||...  ....  .... ||||. ..|| |.  | ||      |...||||||.. |     . |..||..| |..||| |||.|. . .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VSVIIMLCGEEDC----CYQYWI---DSMTYDEFVVKVSSETNASGYIERKLKVSI---DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKS-
|.||.||.....     |.|||    ...||..| |.. ||.. ..|. |.|...    ..||| | ....|.|| .||  .|. .|.....||| ... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

GKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEG---VVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
...||.|||||. |.|.|... . ..||| ..||   .|||... | ||. .||...|||||  .|...  ||..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 5841-6099 2.5e-69 228.9 In-house 23-274 (284) alignment 
Range on Protein: 5841-6099
Range on HMM: 23-274/284.0
NENKALNRLKNITVYDDNRIILTPLSHLECqTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTklkeggKSKCRQYWPNSTSEV
..||  ||. .|  .| |.. | .|   |  ..|||| |. || . .|.|.||||...|| ||||.||. .  .||.||      | || ||||. . . 
dqnkdknrighilafdknvvklerliGeef.sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

KefGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRV--INNWSLSKGTILVHCSAGVGRTGVFIAVDIALE
.  . |.| ..  .   .  .|.. .. . .  |  .. |. .  |||.|||||.. .| | ..|  ...    . .|.||||||||||||.|..|. |.
e..erfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

QAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVERL
. |.|| ||.  .|. ||||| ..||.| || |.. ||||| . |.... . ..   .|.|
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
0047943 (Phosphotyrosine protein) phosphatases II 6101-6357 2e-68 226.1 In-house 4-272 (273) alignment 
Range on Protein: 6101-6357
Range on HMM: 4-272/273.0
KNNRKTNSTKLEAQYNLLYQLTPdPNDVDCKSAKAHASKNRSNNYLPPDKFIVAL-KETDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKV
. ......|.|.....||..|.| . .  . . ... .|||. ..|| |.  | |  ....||||||.. |. |..||..| |..||| |||.|. . .|
llekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

SVIIMLCGEEDC----CYQYWID-----SMTYDEFVVKVSSETNASGYIERKLKVSI--DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSG
.||.||. ...     |.||| .     |.||..| |.. ||.. ..|. |.|...   ..||| | ....|.|| .||   .. .|..|..||..... 
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-KKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYL
 ..||||||||. |.|.|... . ..|.| ..|| |||... | ||. .||...|.|||  .|...  ||
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 6083-6359 2.8e-68 225.4 In-house 1-292 (298) alignment 
Range on Protein: 6083-6359
Range on HMM: 1-292/298.0
GKTEIPIENYSLAVERLKKNNRKTNSTKLEAQYNLLYQLTP--DPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKE-----TDGYINASYLNSYRGKNA
|.|||  |... |...|.. ..|.. |....... | . .   . .  .  ....  .|||  .... |.  | |..        |||||.|..|.|.||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEED----CCYQYWID--SMTYDEFVVKVSSETNASGYIERKLKVSIDK--ESRSVLQLQVTDWPQDGV
||..| |...|| |||.|... ....|.||   |.     . .|| |  . ||.|. |.. |. . . .| ||||||  |  ..|.| ||..| ||. ||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

VREPSTILKIIDEVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
 .. ...|.....|| .|.  .. ||.|.||. | ||| .. ..  ||. ..| ||||||| |.||...|||..| |||. ||..|  .|..
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
0036941 (Phosphotyrosine protein) phosphatases II 6098-6360 5.3e-68 224.8 In-house 2-280 (297) alignment 
Range on Protein: 6098-6360
Range on HMM: 2-280/297.0
RLKKNNRKTNSTKLEAQYNLLYQLTPdPNDVDCKSAKAHASKNRSNNYLPPDKFIVALkETDG--YINASYLNSYRGKNAFILAQSPMENTVRDFWKMIV
 ||. ........|. ..  |..| . . . .. . ... .|||. ..|| |.  | | . .|  ||||||.. |. |..||..| |..||| |||.|. 
llkllekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

DCKVSVIIMLCGEEDC----CYQYWI----DSMTYDEFVVKVSSETN--ASGYIERKLKVSI--DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVRE
. .|.||.||. ...     |.|||     .|.||..|.|.. |..    ..|. |.|.|.   ..||| | ....|.|| .||   |...|..|..||.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

KQKSG-KKGPVVVHCSDTVSRSGVYCSVSIALEQCN---AEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQTT
..|   ..|||.||||. |.|||... . ..|.| .    || ||.... | ||. .|||..|||||  .|...  .|...
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 5817-6115 5.9e-67 221.1 In-house 21-323 (325) alignment 
Range on Protein: 5817-6115
Range on HMM: 21-323/325.0
DSNAFEEQFKNLY-DEEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLI--WQerpV
| ..|  .|. |  |. .   |    |||| ||.||.  .| .|..|  . . . ...||||...  .   . |...| |. .|. |.|||.  |.    
dqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkd.dpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...c

SIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITiQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRV------IN
|.|...   ..|| .| .|||.  .. |.||...| |.  ... |   |.| .  | .  .. .. |.|| ||.| ||. . ....|. . |      ..
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvk.qvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

NWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVERLKKNNRKTN
  . . . ||||||||||||||||..  ||..  .|  ||| | |..||..| .||.. ||| ....|| | ...|.|..|. ..   .  |.. |  |.
antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltq

STKLEAQY
  ..| ..
klniekef
subfamily_PTPN12_pd Subfamily PTPN12 5830-6078 5.9e-67 220.6 In-house 27-275 (290) alignment 
Range on Protein: 5830-6078
Range on HMM: 27-275/290.0
DEEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLEcQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKC
... . ..|...||.. || |.|  || .|. |.  .. | . .||||||. | ......| .|||. .|| ||||.||. .   .||. .. | || ||
ekvysteagekeenvkknrykDilPydksrvelskieeee.gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

RQYWPNSTSEVKEFGPFNVILQNTQTYP-DLFIRKLSITIQdesSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTILVHCSAGVGRTG
..|||... |  |||.|.| |.. ..   |..|| | .. |   ..|... |.. |.|||.|||  |.| ..| . | .  . ..  ..|||||||||||
erYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtG

VFIAVDIALEQAKKEKV---VDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
. ||.|.. |. |.||.   .|.  .| .||.||  .||. .|| ... |..|
tiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
0039614 (Phosphotyrosine protein) phosphatases II 6097-6359 7.5e-67 221.2 In-house 20-291 (297) alignment 
Range on Protein: 6097-6359
Range on HMM: 20-291/297.0
ERLKKNNRKTNSTKLEAQYNLLYQLTPDpndVDCKSAKAHASKNRSNNYLPPDKFIVALKETDG------YINASYLNSYRG-KNAFILAQSPMENTVRD
..|.. ......|.|....  |..|.||     .   ... .|||. ..|| |   | ||  ||      ||||||.. |.  ...||..| |...|| |
dlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetved

FWKMIVDCKVSVIIMLCGEEDC---CYQYWIDSM-TYDEFVVKVSSETNASGYIERKLKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQ
||.|. . .|.||.||. ....   |.||| ... ||..|.|.. ...  .||. |.|.|. ..||| | ..|.|.|| .||   ....|.....||| .
FwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreal

KSG-KKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
..  |.|||.||||. |.|.|...   ..|||.. || |||... | ||. .|||..|..||  .||..  .|..
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0040438 (Phosphotyrosine protein) phosphatases II 6105-6359 9.6e-67 220.8 In-house 14-278 (317) alignment 
Range on Protein: 6105-6359
Range on HMM: 14-278/317.0
KTNSTKLEAQYNLLYQLTPDpnDVDCKSAKAHASKNRSNNYLPPDKFIVALKETD-----GYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKV
| . |.|. ... |..|..|  . .. . ... .|||. ..|| |   | |. ..     .|||||| . .. |..||..|.|..||| |||.|. . .|
ksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgv

SVIIMLCGEEDC----CYQYWI--DSMTYDEFVVKVSSETNASGYIERKLKVS--IDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKsGKKG
.||.||. .|..    |.|||   ...||..|.|.. ||.  .|.. |.|.|.   |.||| | ... |.|| .||   |...|.....|||... ...|
tvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpgg

PVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
||.||||. |.|.|... . ..|||.. || |||... | ||. .|||..|.|||  .||..  ||..
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_PTPN9_pd Subfamily PTPN9 5837-6078 2.2e-66 218.9 In-house 36-288 (297) alignment 
Range on Protein: 5837-6078
Range on HMM: 36-288/297.0
VGKSNENKALNRLKNITVYDDNRIILTPLSHLECqTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNS
. |.. |   || ...  ||. |. |. ... |. ..||||||||||   | ||.||||.| |  ||||..|... . ||| |.. | |. ||.||||..
asklranleknrytdvlcydetrvvlakvdedea.sdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

TSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQdESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWS-------------LSKGTILVHCSAG
. ...||| ..|   ..... |  .|.| |.   . ..| ... .|..|||| |||. |.|.. . . | .. .             .|.  |.||||||
eessaefgdlsvsnveveeeedykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaG

VGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
.|||| ||..||.|.. ... .||.   |..||.||  ..|  .|| | . |.||
iGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPN3_pd Subfamily PTPN3 5819-6078 3e-66 218.2 In-house 15-273 (280) alignment 
Range on Protein: 5819-6078
Range on HMM: 15-273/280.0
NAFEEQFKNLYDEEKP--CDVGKSNENKALNRLKNITVYDDNRIILTplshlECQTEYINANFVDG----YSSSKKFITTQGPMKDTLVDFWRLIWQERP
 |   ||..||  ..   ... .  || . || ..|. ||. |..|.     | .|.|||||.|.      . ....|.||||...|  |||...|... 
Gavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk.....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqks

VSIVMLTKLKEGGKSKCRQYWPNsTSEVKEFGPFNVILQNTQTYPDLFIRKLSITiQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLS
  ||||| | | |. || ||||. |..  |.| |.| ......     .|.| .. . |........| | ..|||.|||| ...|... .|| .  | .
slivmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlk.dketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk

KGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
.  ..||||||.|||||.|....||    ... | .  || ..|.||. .||. .|| |. .|.|.
eePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
0037934 (Phosphotyrosine protein) phosphatases II 5835-6078 7.5e-66 217.4 In-house 2-240 (243) alignment 
Range on Protein: 5835-6078
Range on HMM: 2-240/243.0
CDVGKSNENKALNRLKNITVYDDNRIILtplshleCQTEYINANFVDGYsssKKFITTQGPMKDTLVD----FWRLIWQERPVSIVMLTKLKEGGKSKCR
. .... ||.  || ..|  ||..|..|         . |||||.....   ...| ||||...|. |    |||..|...  .|||||.|.| |. || 
fsiallpenlsknrysdilpydhsrvkl.......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPnstSEVkEFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVIN---N-----WSLSKGTILVHCSA
||||   .|| ..|.| | | ......|  .|.|...  |..  ... |.|. ..|||.||||  ...... . |..   .        |.|..||||||
qywp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

GVGRTGVFIAVDIALEQAkkeKvVDIAGIVNRLRQQRMK-MVQSLDQYLFLHDALLE
||||||..|| .. |..    . ||.  .|..||.||.  .||...|| ||..||||
GvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN6_pd Subfamily PTPN6 5817-6078 1.1e-65 216.7 In-house 24-295 (306) alignment 
Range on Protein: 5817-6078
Range on HMM: 24-295/306.0
DSNAFEEQFKNLYDEE----KPCDVGKSNENKALNRLKNITVYDDNRIILTplSHLECQTEYINANFVDG--YSSSKKFITTQGPMKDTLVDFWRLIWQE
. . |||.|..|  ||       . |. .|||  || |||  .|..|.||.  ..   ...|||||....   .|.|..|.||| ...|. ||||..|||
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqe

RPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKeFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWS
    |||.||  | ||.|| .|||..... . .|  .|   . ..  |  .|.||.. ...........||. .||||.|||     .... . | .. .
nsrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqe

LSK----GTILVHCSAGVGRTGVFIAVDIALEQAKKEKV---VDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
 ..    | |.||||||.|||| || .|| |.. .|...   .||  .|. .|.||  .||  .|| |.. |. .
eleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 5802-6091 3.2e-65 215.2 In-house 9-295 (297) alignment 
Range on Protein: 5802-6091
Range on HMM: 9-295/297.0
PISLDDLAAHIATCYDSNAFEEQFKNLYDE-EKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSskKFITTQGPMKDTL
|| | |.|. . .  ... |.|.|. |     .|  | . . |   .| |||  || .|..|  . . . . .|.|| || |.    ..|||| |||.|.
piplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnd.dpdsDyvnasfvkgnkh..rlittqmPmkatv

VDFWRLIWQERPVSIVMLTKLKEGGKsKCRQYWPNSTSEVkeFGPFNVILQNTQTYPDLFIRKLSITiQDESSDSHTLIQYQLTSWPDQGVPD--YATSF
 |||.....|..  ||||....|. | ||..||.....    ||   |.|. ..       |.|..| ....   . . ||| ..|||. |.    |.|.
adfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevt.kgkakarrvvkqyqfveWPdkaverkdsassl

MSLYRRVINNWSLSKG-TILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIEN
. |   | ...|  .   .||||.||||||||....|  . .||.|| ||| |.|..|||.|...||  .|| |.. |.|| ... .|.|... 
lklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy
0045450 (Phosphotyrosine protein) phosphatases II 6102-6357 8.5e-65 214.8 In-house 20-304 (307) alignment 
Range on Protein: 6102-6357
Range on HMM: 20-304/307.0
NNRKTNSTKLEAQYNLLYQLTPD-PNDVDCKSAKAHASKNRSNNYLPPDKFIVALK------ETDGYINASYL--------NSYRGKNAFILAQSPMENT
 . ... |.|..... |...|.. ... .. . ... .|||. ..|| |   | |.      |...||||||         ..|. |..||..|.|...|
lllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpet

VRDFWKMIVDCKVSVIIMLCGEEDC----CYQYWIDS---MTYDEFVVKVSSETNASGYIERKLKVS---IDKESRSVLQLQVTDWPQDGVVREPSTILK
| |||.|. . .|.||.||......    |.||| |.   .||..|.|.. ||.  .||. |.|.|.    ..||| | ... |.|| .||   ....|.
vedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelld

IIDEVREKQKSG-KKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGV---VDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYL
.|.|||. ...  |.|||.||||. |.|.|...   ..|.| ..||.   ||.... | ||. .|||....|||  .|...  .|
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 6111-6357 3.5e-64 212.0 In-house 2-262 (263) alignment 
Range on Protein: 6111-6357
Range on HMM: 2-262/263.0
LEAQYNLLYQLTPDPnDVDCKSAKAHASKNRSNNYLPPDKFIVALKET-----DGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIML
|..... | . |..  .....  |.  ||||..|.|| |.  | ||..     . ||||.|.. .. |...|..| |...||.|||.|... ||..|.||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CGEEDC----CYQYWIDS----MTYDEFVVKVSSETNAS-GYIERKLKVSIDK--ESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGkKGPVV
. ||..    |..|| ..    .|.... ||. .... .  .| |.|... ..  |.|.| |.|...||. ||  ... .|... .|......  .||.|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYL
||||. |.|.|......|.|.....|  ||.|.. |.|| ..||...|||||. ||...  |.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 6111-6357 3.5e-64 212.0 In-house 2-262 (263) alignment 
Range on Protein: 6111-6357
Range on HMM: 2-262/263.0
LEAQYNLLYQLTPDPnDVDCKSAKAHASKNRSNNYLPPDKFIVALKET-----DGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIML
|..... | . |..  .....  |.  ||||..|.|| |.  | ||..     . ||||.|.. .. |...|..| |...||.|||.|... ||..|.||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CGEEDC----CYQYWIDS----MTYDEFVVKVSSETNAS-GYIERKLKVSIDK--ESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGkKGPVV
. ||..    |..|| ..    .|.... ||. .... .  .| |.|... ..  |.|.| |.|...||. ||  ... .|... .|......  .||.|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYL
||||. |.|.|......|.|.....|  ||.|.. |.|| ..||...|||||. ||...  |.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 5843-6077 4e-64 211.4 In-house 28-265 (274) alignment 
Range on Protein: 5843-6077
Range on HMM: 28-265/274.0
NKALNRLKNITVYDDNRIILTPLSHLECQTEYINANFVDGYSS-SKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSE--
..  || |.|   .  |..|.. |  . ...|||||.. ||.  || .. ||||.  |. ||||.|.||.   |||||||||  ..|| .|.|....   
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

VKEFGPFNVILQNTQTYPDLFIRKLSITIQDEssdSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSL---SKGTILVHCSAGVGRTGVFIAVDIA
 ...| ...  ... .  |  .|||..  . .   ..... |  |.|||. .|| |.....| . | .. .      ....||||||.||||.|||..||
serygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALL
. | ..|.|||. .||  ||..|  |||. .|| ..| || 
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
Y_phosphatase Protein-tyrosine phosphatase 6137-6353 4.5e-64 211.5 Pfam-A 2-233 (235) alignment 
Range on Protein: 6137-6353
Range on HMM: 2-233/235.0
ASKNRSNNYLPPDKFIVAL---KE-TDgYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEEDC----CYQYWI----DSMTYDE
 .|||....|| ||  | |   .. .| ||||.|...|. |..||..| |...|. |||.|... ||.||.||. .|.     | |||     .|.||..
kkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

FVVKVS-SET-NASGYIERKLKVSIDKES---RSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQkSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNA
. |..  .|. . ..|. |||... .||.   |.| ||..|.||. || ..|. .|..|..|.... . |.||||||||. |.|.|......|.|||..|
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
|. |||.|. | ||...||....||||  .|...
eeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 6137-6353 4.5e-64 211.5 In-house 2-233 (235) alignment 
Range on Protein: 6137-6353
Range on HMM: 2-233/235.0
ASKNRSNNYLPPDKFIVAL---KE-TDgYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEEDC----CYQYWI----DSMTYDE
 .|||....|| ||  | |   .. .| ||||.|...|. |..||..| |...|. |||.|... ||.||.||. .|.     | |||     .|.||..
kkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

FVVKVS-SET-NASGYIERKLKVSIDKES---RSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQkSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNA
. |..  .|. . ..|. |||... .||.   |.| ||..|.||. || ..|. .|..|..|.... . |.||||||||. |.|.|......|.|||..|
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
|. |||.|. | ||...||....||||  .|...
eeevdvlqivkelRkqRpgmvqsleqYiflykai
0043336 (Phosphotyrosine protein) phosphatases II 6094-6356 1.6e-63 210.1 In-house 9-276 (278) alignment 
Range on Protein: 6094-6356
Range on HMM: 9-276/278.0
LAVERLKKNNRKTnstkLEAQYNLLYQLTPdpNDVDCKSAKAHASKNRSNNYLPPDKFIVALKE-----TDGYINASYLNSYRGKNAFILAQSPMENTVR
 |...|..|....    |....  |.. ..  .. ..   ... .|||. ..|| |   | |.       ..||||||.. |. ...||..| |...|| 
kallelllnlktl....lllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWKMIVDCKVSVIIMLCGEEDC----CYQYW-IDSMTYDEFVVKVSSETNASGYIERKLKVS--IDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEV
|||.|. . .|..|.||.....     |.|||  .|.||..|.|.. .|.  ..|. |.|.|.   |.||| |.... ..|| .||   .|..|... .|
dFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

REKQKsGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLY
||...  ..|||.||||. |.|.|... . ..||| . || ||.... | ||. .|||..|..||  .|...  |
reale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 5839-6078 4.4e-63 207.6 In-house 3-238 (239) alignment 
Range on Protein: 5839-6078
Range on HMM: 3-238/239.0
KSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSS-SKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNST
|   ||| ||  ||  || .|..|  ||  . ...||||...  |    | .|.||| .. .  ||||..|||| . ||||| | || | ||.||||.||
kkrvnkaknryanivtydhsrvvleklsn.dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SEvkeFGPFNVILQNTQTYPDLFIRKLSITiQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIAL
|.   .  . | |..|. . |  || . .. |   .. . . ||..| |||.|||.|||. . | |.. ..        ..|||||||||| |. .|  |
sk...ycnlrvtlrktevfadyiirtfvms.qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

EQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
 ||||.| |||   |. .|..| .|||. .||.|.| |.||
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 5839-6078 5.2e-63 207.4 In-house 4-239 (239) alignment 
Range on Protein: 5839-6078
Range on HMM: 4-239/239.0
KSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSS-SKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNST
|   ||| ||  ||  || .|..|  ||  . ...||||...  |    | .|.||| .. .  ||||..|||| . ||||| | || | ||.||||.||
kkrvnkaknryanivtydhsrvvleklsn.dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SEvkeFGPFNVILQNTQTYPDLFIRKLSITiQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIAL
|.   .  . | |..|. . |  || . .. |   .. . . ||..| |||.|||.|||. . | |.. ..        ..|||||||||| |. .|  |
sk...ycnlrvtlrktevfadyiirtfvms.qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

EQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
 ||||.| |||   |. .|..| .|||. .||.|.| |.||
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPRD_pd Subfamily PTPRD 6138-6358 7.4e-61 201.4 In-house 50-282 (564) alignment 
Range on Protein: 6138-6358
Range on HMM: 50-282/564.0
SKNRSNNYLPPDKFIVALKETDG-----YINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEE----DCCYQYWIDS--MTYDEFV
.||| .| .. |.  | |....|     |||||....|| ..|.| .| |...|..|||.|. . ..|.|.||   |    . | .|| ..   ||.|..
aKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygelt

VKVSSETNASGYIERKLKV--SIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQkSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVD
|....|.. . |. |..|.  . ..||| | | . |.||. ||  .. ..|..|..||. . . ..||.|||||  | |.|... ... ||. ..|..||
VtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvD

VFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQ
..|. ||||. ..  . | |||  |....  .|.
iyqyvkalrkqRnamVqteeQYiFiheaileala
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 5841-6092 1.1e-60 200.3 In-house 46-291 (439) alignment 
Range on Protein: 5841-6092
Range on HMM: 46-291/439.0
NENKALNRLKNITVYDDNRIILTPLSHLeCQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKskcrqYWPNSTSEV
. ... || |... .|  |..|  .  .  .. |||||...||   | .|.|||| |.|  |||||..... | |||||.| |  |     ||| ..  .
eydqtknrykdvgafdhtrvtlqeipgv.phshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevc

keFGPFNVILQNTQTYPDLFIRKLSIT-IQDESSDSHTLIQYQLTSWPDQGVPDYAtSFMSLYRRVINN--WSLSKGTILVHCSAGVGRTGVFIAVDIAL
  .|   |  .     |.  || . .   .| .   .|..|.. ..|||. ||  | |... . | ||    .   | ..|||||||||||  ||.||||
..ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqa.shvldflrainsandkeeygpvvvhcsagvGrtGtiialdial

EQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENY
|| | |. ||| |||. ||.|| .|||.| ||.|...|.||.|. |.. . |...
eqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 5842-6078 1.2e-60 199.7 In-house 2-237 (237) alignment 
Range on Protein: 5842-6078
Range on HMM: 2-237/237.0
ENKALNRLKNITVYDDNRIILTPLSHLecqTEYINANFVDGYSS-SKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPnSTSEV
|||. ||  ||..|| .|..|         ..||||....|.    ||.|..|||.. .  |||...|||.   ||||| | || . || .||| || . 
enkiknrygnivaydhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqp

KEFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSL--SKGTILVHCSAGVGRTGVFIAVDIALE
. .| . | |.  . . |  .| | .. . .  .   . |||.|||||.|||....... . ...||.       |  ..||||||||||.|. .|  | 
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
|||..|||||   |  . ..|  ..|. |||.|.|...||
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 5831-6078 1.3e-60 199.7 In-house 8-262 (270) alignment 
Range on Protein: 5831-6078
Range on HMM: 8-262/270.0
EEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFVDGYSSS-KKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKC
|... |. .   .|.||| ..|      |..| .|.. . .|.|||||.| |.... ||.|...||.. || .|||.||.|.  .|||.|.|.| |..||
etsesdlpeaargkklnRyadiLPsPatRvrleelee.dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkC

RQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQdESSDSHTLIQYQLTSWPDQGVPDYAT------SFMSLYRRV-INNWSLSKG-TILVHCS
 .|||... |  ..   ..   ....  . . ..  .... |..... |. .. ..|||.|||  .       . ... | |   . .|.|.  .|||||
erYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

AGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
|||||||..||.|||..  ...| ||.. |...||..||..||  .|| ||. |..|
aGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN13_pd Subfamily PTPN13 5815-6078 2.2e-60 199.2 In-house 7-267 (273) alignment 
Range on Protein: 5815-6078
Range on HMM: 7-267/273.0
CYDSNAFEEQFKNLYD--EEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlecqteYINANFVDGYSSSK--KFITTQGPMKDTLVDFWRLIWQE
  |..  .|.||.| .    . |.|||..|||. || .|.  ||. |..|   .       ||||...      .  ..| .|||. .|  |||...|. 
kldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweq

RPVSIVMLTKLKEGGKSKCRQYWPNSTSE-VKEFGPFNVILQNTQTYPDLFIRKLSITiQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNW
.   |.|.|. ||.|| ||..|||.|... .|  . ..| | ..| . .. .|.| .. . ||..|. . . ....||| |||  |.... . ..| .  
kaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk.dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq

SlSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
. ..| |.||||||.||.|..|..|..|.  ...| .|.  ||..||.||  .||. |||.| . |.||
t.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
0040439 (Phosphotyrosine protein) phosphatases II 6127-6356 9.8e-60 197.5 In-house 2-245 (249) alignment 
Range on Protein: 6127-6356
Range on HMM: 2-245/249.0
DVDCKSAKAHASKNRSNNYLPPDKFIVALKE-----TDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEEDC----CYQYWI
.... . ... .|||. ..||.|   | |.       ..||||||.. |. |..||..| |...|| |||.|. . ...||.||. .. .    |.||| 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

--DSMTYDEFVVKVSSETNASGYIERKLKVS--IDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSG-KKGPVVVHCSDTVSRSGVYCSVSI
  .|..|..|.|.. |..  ..|. |.|...   |.||| ||..|.|||| .||   ....|..|..||. ...  |.|||.||||. |.|.|...   .
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

ALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLY
.||| . |. ||.... | ||. .|||....|||  .|...  .
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 6105-6358 4.2e-58 191.9 In-house 19-284 (319) alignment 
Range on Protein: 6105-6358
Range on HMM: 19-284/319.0
KTNSTKLEAQYNLLYQLTPDpnDVDCKSAKAHASKNRSNNYLPPDKFIVALKETDG-----YINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKV
.| .|.|| ...|| . ..|  ..|  | .   .||| .| |. |.  |.|.| ||     |||||....|. ...|| .|.|.|||. |||.|. . ..
stgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

SVIIMLCGEED----CCYQYWIDSM--TYDEFVVKVSSETNASGYIERKLKVSI---DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGKK
|...||..  .     . .|| .    .| ...|.. .| . ..|| ||||. .   . |.|.| . | |.||...| ..  ..|... ..|. ..  ..
sivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqs

GPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQ
||.|||||. | | | .. ....||. . |||.|||.. . ||  ..  . . |||. ||...  ...
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 6135-6359 8.7e-58 190.5 In-house 8-244 (250) alignment 
Range on Protein: 6135-6359
Range on HMM: 8-244/250.0
AHASKNRSNNYLPPDKFIVALKETD-----GYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG---EEDCCYQYWI--DSMTYDE
.   |||  .... |.  | |....      |||||.|..|....||| .|.|...|. |||.|... |...|.||     .|  . |||    . .| .
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGd

FVVKVSSETNASGYIERKLKVSIDKESRS--VLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGV
  |.. |. . . |. ||||.|  |.. .  | ||. . ||  || ..  ..|.....|. .|.  ...||.|.||  |.||| .. ..  ||. . | |
vtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekv

VDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
||||.| |.||. .|.|...|||| ..| ..  .|..
vdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 6133-6359 1.5e-57 190.1 In-house 43-282 (318) alignment 
Range on Protein: 6133-6359
Range on HMM: 43-282/318.0
AKAHASKNRSNNYLPPDKFIVALKETD-----GYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEED----CCYQYWID--SMT
 .. . ||| .| |. |.  |.|....      ||||.|.. || |.|.| ||.|. .|..|||.|. . . .||.||  ||.     . .|| .  |..
epvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrs

YDEFVVKVSSETNASGYIERKLKVSID--KESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNA
|.. ||....|.. | |. |..||. .  .||| | | ..|.||. ||  .....|... .|.. |.. ..||.|||||  | | ||.. |.| ||. .|
ygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerika

EGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
|..|||||. | ||. ..  . | .||. ||||.  .|..
ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_PTPN14_pd Subfamily PTPN14 5831-6078 1.7e-57 189.7 In-house 37-294 (300) alignment 
Range on Protein: 5831-6078
Range on HMM: 37-294/300.0
EEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLecQTEYINANFVDGYSSS--KKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSK
|.  ....| .||.  || |..  |.|||. |.|  .   .|.||||  .    ..  ...|..|||.. |. |||...|..    |||||. .|.|| |
edallstaklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

CRQYWPNSTSE--VKEFGPFNVILQNTQTYPDLFIRKLSITIQdESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRV------INNWS---LSKGTIL
. .|.|...|.    ||| |.|. . ... . .  ..| .     |..  |..  | | |||.|||.  ..|.|  ..|       |. .    ||  .|
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl.pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
|||||||||||| | .|. ..  ......||  ...|||.||| .||.| || |....|..
vhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
0045098 (Phosphotyrosine protein) phosphatases II 6119-6358 4.5e-57 188.9 In-house 16-273 (278) alignment 
Range on Protein: 6119-6358
Range on HMM: 16-273/278.0
YQLTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVAlketdGYINASYLNSYrgKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEEDC----CYQ
  |...|... .     ...|||  ..|| |   |      .||||||...|  ...||..| |...|| |||.|. . ...||.||.....     |.|
llllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWID--SMTYDEFVVKVSSETNASGYIERKLKVS------IDKESRSVLQLQVTDWPQDGVVREP--STILKIIDEVREKQK------------SGKKGP
|| .  |.||..|.|.. ||.. . |. |.|.|        | ||| | .|. . ||  ||  .|  . .|......|| .|             ...||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

VVVHCSDTVSRSGVYCSVSIALEQCnaEGVVDVFQVTKALRRSKPG-AITTLEQYTSIYDVVDLYLQ
|.||||  |.|.|... . . ||..  ||.||.... | ||. .|| |...||||  .|... ..|.
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0042113 (Phosphotyrosine protein) phosphatases II 6129-6356 4.9e-57 188.5 In-house 2-242 (245) alignment 
Range on Protein: 6129-6356
Range on HMM: 2-242/245.0
DCKSAKAHASKNRSNNYLPPDKFIVALKETDG-----YINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEEDC----CYQYWI--
.. . ... .|||. ..|| |   | |....|     |||||| . || .. ||..| |...|| |||.|. . ....|.||. ||.     |.|||   
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

DSMTYDEFVVKVSSETNASGYIERKLKVS--IDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALE
.|.||..|.|.. ||.. ..|. |.|.|.   |.||| |.... ..|| .||   ....|.....||. ......|||.||||. |.|.|... . ..||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

QCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLY
| ..|. |..... | ||. .|||..|..||  .|...  .
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_CG7180_pd Subfamily CG7180 5833-6085 1.2e-56 186.6 In-house 32-295 (296) alignment 
Range on Protein: 5833-6085
Range on HMM: 32-295/296.0
KPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLEcQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKsKCRQY
  |  |  .||.  ||  ..  || ||..|. |   | ...|||| .||..   |..| |..|.|.|. .||||...|   ..|.|||  .  | .. .|
gdCagglrkenreknrdvkvvPyDynRvvLekldGee.ksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPNSTseVKEFGPFNVILQNTQTYPDLFIRKLSITIQ---------DESSDSHTLIQYQLTSWPD-QGVPDYATSFMSLYRRVINN---W--SLSKGTIL
||| .   ...|.. | . ....|..| ||.. .| .         ... .  .. ..||| |.  . ||  ..... | |||            .| ..
wpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKT
|..| |..|.||..|.|..||...||. ||. . | .||..| ..|.. ..| .. | ||| ..|.|.
vvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_Ptp69D_pd Subfamily Ptp69D 6098-6353 1.2e-56 187.1 In-house 12-282 (307) alignment 
Range on Protein: 6098-6353
Range on HMM: 12-282/307.0
RLKKNNRKTNSTKLEaQYNLLYQLtPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKETDG-----YINASYLNSYRGKNAFILAQSPMENTVRDFWK
 ||...|.|.  ...  |. | .    . .      |  | |||...  . ||  | ||.. |     |||||....|. |. || || |.|.|. |||.
alksrkrdtdfglak.eyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWR

MIVDCKVSVIIMLCGEEDC----CYQYWI--DSMTYDEFVVKVSSETNASGYIERKLKVSIDK-------ESRSVLQLQVTDWPQDGVVREPSTILKIID
|| . .| .|.||  ...     | .||   | . |.. .||. || ..| ||.|.|.||  |       .|| |.| . | |.   | . . ..||.|.
miaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklie

EVREKQKSGkKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
.||| .|   ..|.|||||  |.|||.. .... |.|..||  ||.|...| ||. ..  .. ||||. .|  .
qvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 5802-6106 1.2e-53 176.9 In-house 3-262 (392) alignment 
Range on Protein: 5802-6106
Range on HMM: 3-262/392.0
PISLDDLAAHIATCYDSNAFEEQFKNLYDEE-KPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLeCQTEYINANFVDGYSSSKKFITTQGPMKDTL
||   .. | .     |  | |.|..| . .  |  |.. . |.  || |||  || .|..|  .     ...|.|| ..... . | .|..|||   .|
pipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddi.pdsdylnasyipsfdnekayiasqgpnaasl

VDFWRLIWQERPVSIVMLTKLKEGGkskcrqywpnstsevkefgpfnvilqntqtypdlfirklsitiqdESSDSHTLIQYQLTSWPDQGVPDYATSFMS
 ||||...||.. .|.|.||||||                                                 | .|  |...| |||..|| ...|.. 
ddfwrmvfqenvttiamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllk

LYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIPIENYSLAVERLK
. . |  ..      ...||||||||||| |..|  . .||| ..||.  .|  .|..|  |||. .|| |.. |.||...  .| ||.  ..  .. |.
fikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls

KNNRKT
      
tssdGd
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 6108-6353 1.8e-53 176.2 In-house 5-262 (283) alignment 
Range on Protein: 6108-6353
Range on HMM: 5-262/283.0
STKLEAQYNLLYQLTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALK-ETDGYINASYLN---SYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVII
... ..... | .|.  . |.|..||. .  ||| .. .| |...| || |.  ||||...    ||. .. .| ||||...||.|||||. | |.. |.
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLC----GEEDCCYQYWID--SMTYDEFVVKVSSETNASGYIERKLKVSIDKESRS---VLQLQVTDWpqdgVVREPSTILKI---IDEVREKQKSGKKG
||     ...  | |||    |. | || | .  ||    .| ..| .  .  ..|   .   || ||    .  .. .|.     .. |. .|.  |||
mltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkg

PVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
|.||||| .. |..|....| ....  .| |||||.| | .|  ...|. ||.||  ....|
PivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPN23_pd Subfamily PTPN23 5816-6079 2.6e-53 175.7 In-house 12-279 (288) alignment 
Range on Protein: 5816-6079
Range on HMM: 12-279/288.0
YDSNAFEEQFKNLYDEEKP----CDVGKSNENKALNRLKNITVYDDNRIILTplshlECQTEYINANFVDGYSS-SKKFITTQGPMKDTLVDFWRLIWQE
 .  |....||.| ....       .  .. .   || ..|  || ||. |      . . .|||| || . |. . .||.||.|.. || |||......
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

RPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESsDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWS
.   ||||.. .| || |. .|||... | ..||...| |..... .    |.|.....|..   ...   ||||||. |||.   ... .   | . ..
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesaye

LS----KGTILVHCSAGVGRTGVFIAVDIALEQ-AKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEE
      |  ..|||||||||||||  |  |...  |.. ..||  .|.|||.||  |||  .|. |. .| ||.
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0037934 (Phosphotyrosine protein) phosphatases II 6130-6356 6.6e-53 175.1 In-house 4-241 (243) alignment 
Range on Protein: 6130-6356
Range on HMM: 4-241/243.0
CKSAKAHASKNRSNNYLPPDKFIVALKEtDGYINASYLNSYrgKNaFILAQSPMENTVRD----FWKMIVDCKVSVIIMLCGEE----DCCYQYWIDSMT
. . ... ||||  ..|| |   | |.  ..||||.. . .  .. .|. | |...|| |    ||.|. . ...||.||. ..      |.||| ...|
iallpenlsknrysdilpydhsrvkleg.sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevt

YDEFVVKVSSETNASGYIERKLKVSI---DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKS-------GKKGPVVVHCSDTVSRSGVYCSVS
|..|.|.. ||.. ..|. |.|...    |...| | ... . ||  ||  .|. .|...||||| ...        ..|||.||||  |.|.|...   
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaay

IALEQCnaeGvVDVFQVTKALRRSKPG-AITTLEQYTSIYDVVDLY
. |...   | ||.... | ||. .|| |..|..||  .|...  .
lmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRK_pd Subfamily PTPRK 6129-6353 1.1e-51 170.5 In-house 36-273 (314) alignment 
Range on Protein: 6129-6353
Range on HMM: 36-273/314.0
DCKSAKAHASKNRSNNYLPPDKFIVALKETDG-----YINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG-EED---CCYQYWID-
|.   . . .||||.. |..|.  | |. .||     ||||....||.  .||| .| |...||.|||... | . . |.||    |     |..|| . 
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

SMTYDEFVVKVSSETNASGYIERKLKVSI----DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSgKKGPVVVHCSDTVSRSGVYCSVSIAL
...|... |.. . .  . .. | ..|.      .| | | |.| . ||. .|  .  ..||.. .| ..|.  ..|..|||||    |.|... ..| |
tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

EQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
.  . |||||||.. |.|| .|.  . | |||. ||||.
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPN1_pd Subfamily PTPN1 5821-6084 1.3e-51 170.1 In-house 8-275 (290) alignment 
Range on Protein: 5821-6084
Range on HMM: 8-275/290.0
FEEQFKNLYDEEK--PCDVGKSNENKALNRLKNITVYDDNRIILTplshlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVML
..| .... .| .  |. . | .||..||| .... ||  ||.|      . ...||||..|.     ...| ||||. .|   ||...|...  ..|||
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle.....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml

TKLKEGGKSKCRQYWPNSTS-EVKEFG--PFNVILQNTQTYPDLFIRKLSITiQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSK--
 |. | .. || ||||.  . .  ..    ..| | .....    .|.| .. . .. ........  |.||| |||.  ..|...  .| .  |||.  
nkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllele.nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdv

GTILVHCSAGVGRTGVFIAVDIALEQAKKEK---VVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGK
|  ..|||||.||.| |. ||  | . .|..    |||   .  ||..|. ..|  ||  | . |.|| . . |
GpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvik
subfamily_PTPRA_pd Subfamily PTPRA 6128-6356 2.5e-51 169.5 In-house 50-294 (330) alignment 
Range on Protein: 6128-6356
Range on HMM: 50-294/330.0
VDCKSAKAHASKNRSNNYLPPDKFIVALKETDG-----YINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG----EEDCCYQYWID
..  | .    |||  | || |   | | . .|     |||||... |. |. || || | |.|| |||.|| . | . |.||      .|. |.||| |
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

--SMTYDEFVVKVSSETNASGYIERKLKVS------IDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSgKKGPVVVHCSDTVSRSGVYCSV
  ..|| .  |.|  || .  |  ||. |        .|.|| | |.  | ||. ||  ||  .||.. .|.....  . ||.|||||  | |.| .. .
eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq.sagpivvhcsaGvGrtGtfivl

SIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLY
.  ||. .||..||||.. | ||  .|  . |.|||. || |.  |
davlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRN_pd Subfamily PTPRN 5825-6080 1.5e-50 166.6 In-house 38-292 (297) alignment 
Range on Protein: 5825-6080
Range on HMM: 38-292/297.0
FKNLYDEEKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHlECQTEYINANFV-DGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKE
...   |.. ..|.|...|   || |..  ||..|. |.  .  . ...|||| .. |    .  .|.||||. .|. |||...|..  | ||.||.|.|
lcayeaepstkevakaeknvkknrskavlpydhsrvklkeeas.aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrlee

GGKSKCRQYWPNSTSEVKEFgpFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTILVHCSAG
 | ..|..|||.  ||| ..  ..| |     . | .. .     . ..|.. |. |.   |||..|||  | |.. . |.|   .     .|.||||.|
egvkqckrywpdeGsevyhi..yevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdG

VGRTGVFIAVDIALEQAKK-EKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEI
.|||||.|..|. |.. .|  | .|||  .. ||.|| ..|.. ||. |   |. ||.
aGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 6134-6358 2.1e-50 166.6 In-house 47-285 (297) alignment 
Range on Protein: 6134-6358
Range on HMM: 47-285/297.0
K--AHASKNRSNNYLPPDKFIVALKE--TD---GYINASYLNSYRGknAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEE---DCCYQYWIDS--MT
.     .|.| .| || |.  | |.   .|    |.|||......    .|  | ||..|| |||.|..| .||.|.||  ..   . | .|| |.  .|
ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt

YDEFVVKVSSETNASGYIERKLKVSIDK--ESRSVLQLQVTDWPQDGVVR--EPSTILKIIDEVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQC
. . .|...| .. .|.|.|.|.|. .|    | | | | ..||.. | |  . |..||.|.|||.. .. ..||..|||.  | | ||....   . . 
fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaea

NAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQ
. |  ||.|.. | ||...|  . | |||. .| .|  .| 
krekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_PTPN12_pd Subfamily PTPN12 6131-6358 2.8e-50 165.9 In-house 35-278 (290) alignment 
Range on Protein: 6131-6358
Range on HMM: 35-278/290.0
KSAKAHASKNRSNNYLPPDKFIVALKE-----TDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEE----DCCYQYWIDS--
 ... .  |||  . || ||  | |..      ..||||....   || ..| ||.|. .|. |||.|| ...|....|.| |       | .|| ..  
gekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

--MTYDEFVVKVSSETNAS-GYIERKLKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKsGKKGPVVVHCSDTVSRSGVYCSVSIALEQ
  ....|| |....| . . ... | |||  .||||.| |.. |.||  || . ....|..|..||| |.  .. |.|||||  | | |. ... .. |.
eelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrel

CNAEGV---VDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQ
 .|| .   .|||..   ||. .. .. | |||. .|  |  ..|
lkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 6100-6351 3.1e-50 166.3 In-house 25-285 (319) alignment 
Range on Protein: 6100-6351
Range on HMM: 25-285/319.0
KKNNRKTNSTKLEAQYNLLYQLTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKETDG-----YINASYLNSYRGKNAFILAQSPMENTVRDFWKMI
.|.. . . ||||.... . .|...  | .    .    |||  | |. || .| |. ..|     |||||... |. |. .| || |..||. |||.||
nksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmi

VDCKVSVIIMLCgeEDCCYQYWIDS--MTYDEFVVKVSSETNASGYIERKLKVSI---DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVRE-KQKSG
 . ..| |..|   .| | |||     .....| |||.| .... |. |....|     |. |.. |     ||. ||   || ...... ||  ..|  
weyncstivllt..kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsken

KKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYD
.. ..|||||  | |.|||  . . |.. . |  |||... . ||. ..  .  | ||  || 
hranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
0051429 (Phosphotyrosine protein) phosphatases II 5873-6101 3.7e-50 166.4 In-house 5-245 (272) alignment 
Range on Protein: 5873-6101
Range on HMM: 5-245/272.0
EYINANFVDGYSS---SKKFITTQGPMKDTLVDFWRLiWQERPVSIVMLTKLKEGGKSKCRQYWP----------NSTSEVKEFGPFNVILQNTQTYPDL
 ||||..|.|| .    .... ..||.. |  ||||| ....  .||.|... | |. || .|||          ... .  ..| . |.|. .....| 
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

FIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYAtsFMSLYRRVINnwslsKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVD--------IAGI
 .|.| .|..   ...... ... |.||| |||. |  . .| . . .     .| .|||||||..|||...|... |..  .| .||        ....
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VNRLRQQRMKMVQSLDQYLFLHDALLEEiICGKTEIPIENYSLAVERLKK
|..||.||...||. .|||||..||||  ... .... | .  |.. ...
veelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaide
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 5841-6078 1e-49 163.8 In-house 54-281 (290) alignment 
Range on Protein: 5841-6078
Range on HMM: 54-281/290.0
NENKALNRLKNITVYDDNRIILTPlshlECQTEYINANFVDGYSSskKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEV
| .   || |...  |  |.||        . .|. ||.|.|  .   || |||..||| .|.||.. ||.   |||| .| | ||.|| ||.|.   ||
ntefkknrykdvvcndktrvilkd....GydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

KEFGPFNVILQNtQTYPDLFIRKLSITIQD-ESSDSHTLIQYQLTSWPDQGVPdyaTSFMSLYRRvINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQ
  || . |.  . .. .|  | |  ....| .|  .| |  ... ||||. |.    | ..| |  .       | . ||||||.|||| |.|....|. 
ltfGeitvlcse.eddkdaniikktlsvrdkdsGkehklkhlkikswpdksva...lstlallrt.lrilrkasGpvvvhcsaGiGrtGtfvaievglqi

AKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
  . | .|....|  ||. |.. ||   ||| | ..||.
lldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_CG7180_pd Subfamily CG7180 6104-6356 1.1e-49 163.7 In-house 8-289 (296) alignment 
Range on Protein: 6104-6356
Range on HMM: 8-289/296.0
RKTNSTKLEAQYNLLYQLTPDPNDVDCKSA--KAHASKNRSNNYLPPDKFIVALKETDG-----YINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVD
  ..  | ...|.|...|||  .  ||. .  |    |||  . .|.|.. | |.. ||     ||||.| .|.  |...|  . |...|| .||... |
lvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvyd

CKVSVIIMLCGEEDC---CYQYWIDS--MTYDEFVVKVSSETNASGYIERKLKVS------------IDKESRSVLQLQVTDWPQ-DGVVREPSTILKII
 ..| ...|. . |    . .||       | |..|.. .| . .    |..|.             .. | | |...|.| |.  | |    .......
eeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielr

DEVREKQKSG----KKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLY
  ||  ..      ..|||||..|| .||||||... ..||. . |. ||||.  | ||||.|. . . |.|  ||||.  .
rrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 6103-6353 2.2e-49 163.1 In-house 15-275 (288) alignment 
Range on Protein: 6103-6353
Range on HMM: 15-275/288.0
NRKTNSTKLEAQYNLLYQLTPDPNDVDCKSAkAHASKNRSNNYLPPDKFIVALKE-----TDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDC
  ..| | .. .|| | .|  . ..   . |   |.||| .| || |   | ||.     .  ||||||......|...| .|.|. .|| |||... . 
ksarnrtgfseeynsLaalektksvtagrla.vnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

KVSVIIMLCG----EEDCCYQYWIDSMT---YDEFVVKVSSETNASGYIERKLKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGkK
|.| |.|| .    ..  | .|| |. .   | .. |.. .. .   ...||| .  .|. . . |.| . ||..|| .    .|.... |   ...   
ktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.t

GPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
||..||||. | |.|.. ..  .... ..| ..||. . . ||....  . ||.||  ||.|.
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 6119-6358 5.9e-49 161.6 In-house 25-278 (315) alignment 
Range on Protein: 6119-6358
Range on HMM: 25-278/315.0
YQLTPDPNDVDCKSAKA--HASKNRSNNYLPPDKFIVAL-----KETDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG--EE
..  |||.    ..|.     .||| .| || |.  | |     .  . ||||||..|.   .|.| .| | . .| |||.|... ||. |.|.    |.
fhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqeg

DC--CYQYWID----SMTYDEFVVKVSSETNASGYIERKLKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKqKSGKKGPVVVHCSDTVSR
|   | ||| |    |. . .. |.. |    .. . ||| .   .||| | | | |.||. || .. |..||.| ||. . .  |. ...||||  | |
dkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGr

SGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQ
.|| .|.   ..| . . .||||.. | ||. .|  . | |.|. |||.|  .|.
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPRB_pd Subfamily PTPRB 6101-6358 8.2e-49 161.2 In-house 17-286 (293) alignment 
Range on Protein: 6101-6358
Range on HMM: 17-286/293.0
KNNRKTNSTKLEAQYNLLYQLTPDpNDVDCKSAKAHASKNRSNNYLPPDKFIVAL-----KETDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIV
|.... . ...  .|. | ..  | . |.. .... ..||| .| || |.  | |     .... ||||.|.. |. .. || .| |. .|| |||.|. 
kkmkadsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvw

DCKVSVIIMLC--GE--EDCCYQYWIDS---MTYDEFVVKVSSETNASGYIERKLKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQ-KS
. |.|.|.||    |     | .|| .    ..| .  |.. .|.. . .. |.||.. .||.|.| |.. | ||. ||  ...|.|... .|||.. |.
ekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiekt

GKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQ
 .|.|.|||||  | |.|.. ..   |.. . | .||.| .  .||...   . | .||  |...|  .|.
askrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPRG_pd Subfamily PTPRG 6088-6353 1.1e-48 160.8 In-house 2-283 (563) alignment 
Range on Protein: 6088-6353
Range on HMM: 2-283/563.0
PIENYSLAVERLKKNnrktNSTKLEAQYN-LLYQLTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKETDG------YINASYLNSYRGKNAFILAQ
|.....  |  |. .    . ........ |  . ...  |..  ...    |||  | .. |.  | |... |      ||||.|.. |. ..||| .|
pvkefakhvaslhad....gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatq

SPMENTVRDFWKMIVDCKVSVIIMLCG----EEDCCYQYWI--DSMTYDEFVVKVSSETNASGYIERKLKVSI-------D-KESRSVLQLQVTDWPQDG
 |...|. |||.|| . .|..|.|.      .   | .||   .|.||... |.  .|   . | .|.|..         . .. . | | . |.||. |
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg

VVREPSTILKIIDEVrEKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
|   .   |. .    .. .  . ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  ..| |||. ..|..
vPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal
subfamily_PTPN6_pd Subfamily PTPN6 6095-6360 5.7e-48 158.5 In-house 12-300 (306) alignment 
Range on Protein: 6095-6360
Range on HMM: 12-300/306.0
AVERLKKNNRKTNSTKLEAQYNLLYQLTPDPNDVDCKSAK-AHASKNRSNNYLPPDKFIVALK--ETDG--YINASYLN-S-YRGKNAFILAQSPMENTV
 |..|.|.. ... . .| ... | |          ..||   ..||| .| || |.  | ||  .. |  ||||.|.. .    ....| .|  .|.||
rvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettv

RDFWKMIVDCKVSVIIMLCGEED----CCYQYWIDSMTYDEF---VVKVSSETNASGYIERKLKVS---IDKESRSVLQLQVTDWPQDGVVREPSTILKI
 |||.|... .  ||.|.  | .     |..|| |. . .|.    |.  ||.... || |.|.||    .||.|.| |.. ..||. || ..|...|. 
sdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdf

IDEVREKQKSGK---KGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGV---VDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQTT
...|..||.. .   .||.|||||. . | | .  . | |.. . .|.   .|. .. | .|. . | . | .||  .| ..  |..|.
ledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 5815-6077 5.8e-48 158.1 In-house 20-274 (287) alignment 
Range on Protein: 5815-6077
Range on HMM: 20-274/287.0
CYDSNAFEEQFKNLYDEEKpcdvgksnenKALNRLKNITVYDDNRIILTPLShlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVS
. ||..    ||.  .  .             ||  ..  .||.|..|.  .  |  ..|||||.| .|   ..||..|||.  |. ||||.....|  |
kedsesstatfkaaeelaa..........vkknryadvlPiddtrvllsaeg..elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsas

IVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSItIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRV-----INNW
....|.  | .. || .|||.    ..  |   |.|. ..  |.  .| | . |. |. ... . |..| ||||....  | ... .   |     ..  
vitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrl.idletrearvvkqldllswPdkvlaPtavglirfvldvkqhielard

SLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALL
.   | ..||...|.||.|...|. . ... ..   ||.| .| |||..|  .||.  |. .| .|| 
asevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 6121-6351 1.6e-47 157.3 In-house 10-249 (284) alignment 
Range on Protein: 6121-6351
Range on HMM: 10-249/284.0
LTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKETDG-----YINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCgeEDCCYQY
|...  |      .    |||  . |. || .| |. ..|     |||||... |. |. .| .| |..||. |||.|| . ..| |..|   .| | ||
lgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqy

WIDS--MTYDEFVVKVSSETNASGYIERKLKVSI---DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVRE-KQKSGKKGPVVVHCSDTVSRSGVYCS
|     .....| |||.| .... |. |....|     |. |.. |     ||. ||   || ...... ||  ..|  .. ..|||||  | |.|||  
wplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

VSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYD
. . |.. . |  |||... . ||. ..  .  | ||  || 
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 6135-6353 3.5e-47 155.9 In-house 48-275 (315) alignment 
Range on Protein: 6135-6353
Range on HMM: 48-275/315.0
AHASKNRSNNYLPPDKFIVAL--KE---TDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLC----GEEDCCYQYWID-SMTYDE
    |||  | .. ||  | |   |      |.||.... |  |. .| ||.|  ..|.|||... . ... |.||     ||.  . .|| |  ..| .
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGk

FVVKVSSETNASGYIERKLKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGKkGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVD
. |   ||   . |  | | |  ... | |.||..| ||. || .   .....|  |.  ...   |..|||||. | |.| .....  |.| .|| ..|
itvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaid

VFQVTKALRRSKPGAITTLEQYTSIYDVV
|... . .|. . ... ..|||  |||..
vynfitgvrqnrikmvqvaeqyqfiydal
0041856 (Phosphotyrosine protein) phosphatases II 5843-6088 6.8e-47 154.7 In-house 1-179 (182) alignment 
Range on Protein: 5843-6088
Range on HMM: 1-179/182.0
NKALNRLKNITVYDDNRiiltplshlecQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTklkeggkskCRQYWPnstsevke
|. .|| ..|  || .|              |||||...|.  ...|| ||||...|. ||.|......  .||.||         ...|||        
nldknrysdilpydhsr...........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp........

fgpfnvilqntqtypdlfirklsitiqdeSSDSHTLIQYQLTSWPDQGVPDyATSFMSLYRRVINnwslSKGTILVHCSAGVGRTGVFIAVDIALEQakk
                             .   .. |||. ..||| ||||   .. .. ..|..    ..|..||||||||||||...| .. ...   
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl...

eKvVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGKTEIP
 . |..  .|. .|..|..||....|| ||..||||.. ..||...
.g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_PTPN23_pd Subfamily PTPN23 6104-6353 7.1e-47 154.6 In-house 10-276 (288) alignment 
Range on Protein: 6104-6353
Range on HMM: 10-276/288.0
RKTNSTKLEAQYNLLYQ-LTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALK-ETDGYINASYLNSYR-GKNAFILAQSPMENTVRDFWKMIVDCKVS
   . |.|......| |    . ..  .  || ...||||.. || |.  | |. ..| |||||....   |   || .|.|...|. |||.|... |.|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkss

VIIMLCGEEDC----CYQYWI----DSMTYDEFVVKVSSETNASGYIERKLKVSIDKE--SRSVLQLQVTDWPQDGVVREPSTILKIIDEVRE---KQKS
||.||  .|.     . .||     ........ | ..|..... ..||.||... ..   .||  ||.| ||. ||   |.|.|...|||..   ... 
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqr

GKKGPVVVHCSDTVSRSGVYCSVSIALEQCNA-EGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
  | |.|||||  | |.||.. |  |... .. .|..|. || . ||. .   . . ||.   |..|
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 6119-6353 6.1e-46 152.0 In-house 29-284 (325) alignment 
Range on Protein: 6119-6353
Range on HMM: 29-284/325.0
YQLTPDPNDVDCKSAK--AHASKNRSNNYLPPDKFIVALK---E--TDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIML---CGE
..|.|  . .  | |   .  .||| .| .. ||  | |.   .     |||||||.....|. |. ||.|. .|. |.|....| . ||...|    ..
fgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlg

EDCCYQYWI----DSMTYDEFVVKVSSETNASGYIERKLKVSIDKE--SRSVLQLQVTDWPQDGVVREPSTI---LKIIDEVREKQKS--GKKGPVVVHC
.| | .||     .| |.  . ||. .  . | |. |.|.|   |.  .||| |.|.  |.. || . |.|.   |.....| |. ..     .|..|||
kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

SDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
|. | |.||. |.  ||..   |  ||.|.. | ||. .|  . | .||. ||. .
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 6132-6359 8.9e-46 151.2 In-house 24-270 (274) alignment 
Range on Protein: 6132-6359
Range on HMM: 24-270/274.0
SAKAHASKNRSNNYLPPDKFIVALK------ETDGYINASYLNSYRGK-NAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG--EE--DCCYQYWIDSM
.   ...||| .. || ..  | |.      |   |||| |.  |... .|.. .| |. ||| |||.||   .|.||.||    |.  . | .|. |. 
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

------TYDEFVVKVSSETNASGYIERKLKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKS--GKKGPVVVHCSDTVSRSGVYCSVSI
      .|... .||.. ..  .|  ||| ..  ...|||     ||||   . ....|.|....||.|....   | .|||||||  . | |.. ..||
dyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
|. | ..|.||||....  ||  . | . | |||  |. .. |||. 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 6138-6358 1.2e-45 150.6 In-house 45-277 (515) alignment 
Range on Protein: 6138-6358
Range on HMM: 45-277/515.0
SKNRSNNYLPPDKFIVAL-----KETDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEE----DCCYQYWID----SMTYDE
.||| .| || |.  | |     .    |.||||..|.   .|.| .| | . .| |||..... .|. |.|.   .      | .|| |    |. . .
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGs

FVVKVSSETNASGYIERKLKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGKkGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVD
. |.. |    .| | |||.|  ...|| | | . |.||. || .. |..||.| ||. ..   .  |...|||  | | ||..|.   . . .   .||
ikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvd

VFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQ
||.. . .|. .|  . | |||. ||..|  .| 
vfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPN3_pd Subfamily PTPN3 6106-6352 8.3e-45 147.9 In-house 12-270 (280) alignment 
Range on Protein: 6106-6352
Range on HMM: 12-270/280.0
TNSTKLEAQYNLLYQLTPDPNDVDCKSAkAHASKNRSNNYLPPDKFIVALKETD-GYINASYLNSY----RGKNAFILAQSPMENTVRDFWKMIVDCKVS
 .| .. ||.. ||.  |. .   .. . . .||||  . || |.  | |||..  ||||.|.|         | .| .| |...|. |||.|. . |.|
lesGavlaqfeqlyrkkpglaisaarkp.enlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss

VIIMLCGE----EDCCYQYWI---DSMTYDEFVVKVSSETNASGYIERKLKVSIDK--ESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKqKSGKKG
.|.||          |.|||    |...| || ||...| . . |. |.| ..  .  |.|..|||| ..||. ||  ... .|.....||.. .|||. 
livmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl.rsgkee

PVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDV
|||||||  . |.||.  . .||   .|.  | . .. . .|  .   . | .||. . . 
PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea
0036282 (Phosphotyrosine protein) phosphatases II 5873-6074 3.1e-44 146.1 In-house 3-164 (174) alignment 
Range on Protein: 5873-6074
Range on HMM: 3-164/174.0
EYINANFVDGYSSSKKFITTQGPMKdtlvdFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNstsevkefgpfnvilqntqtypdlfirklsitiqDES
 ||||...|..  ....| .|||..     ||.......  ..|||...|| |. || .|||                                   . .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lre

SDSHTLIQYQLTSWPDQGVPDYATsFMSLYRRVINNWSL-SKGTILVHCSAGVGRTGVFIAVDIALEQAKkEKVVDIAGIVNRLRQQRMKMVQSLDQYLF
. ... |||. . ||| |||| .. . .....| .  |  ..|..||||||||||||...| .. | . . |..||.  .| .||.||..|||. .|| |
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

LHD
|..
lyy
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 6108-6358 1.3e-43 144.1 In-house 14-277 (281) alignment 
Range on Protein: 6108-6358
Range on HMM: 14-277/281.0
STKLEAQYNLLYQLTPDPNDvDCKSAKAHASKNRSNNYLPPDKFIVALKE-----TDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVI
.. .  .|. |...  |        |..   ||| .|    |.  | ...     .  ||||.....|.|....| .|.|. ... .||.|... |||.|
naGfieeyeklaaigvdnta.taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

IMLCGEED----CCYQYWIDSM---TYDEFVVKVSSETNASGYIERKLKV-SIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGKKGPVV
.|.  | .     |..|| |     .| ...||  .|.. . |||||.|.   . |.|.| ||. | ||. ||  ... .|.  .||.. ... .| |.|
vmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplv

VHCSDTVSRSGVYCSVSIALEQCNAE-GVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQ
.|||  | |.|.| ..  ......||   .|| .| . ||...   . |. ||. .| .|  .|.
ihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN13_pd Subfamily PTPN13 6113-6353 4.8e-42 139.1 In-house 15-265 (273) alignment 
Range on Protein: 6113-6353
Range on HMM: 15-265/273.0
AQYNLLYQLTPDPNdvdCKSA--KAHASKNRSNNYLPPDKFIVALKETDGYINASYLNSYRGKNAF--ILAQSPMENTVRDFWKMIVDCKVSVIIMLCGE
 ... | .| |  .   |...  |.. .|||  | || |.  | |..  ||||||...   ||. .  |..| |. .||.|||.|. . |..||.|.  |
eefkelrelkpldt...cevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

ED----CCYQYWIDS-----MTYDEFVVKVSSETNASGYIERKLKVS--IDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKsgKKGPVVVHC
 .     | .|| .|     . .. . |..   .. .|.  |.|.|.    .||| | .|. ..||  || ...  .|... |||. |.  ..||.||||
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhc

SDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
|  . |||.. .. ..|.  . .  .|| .. . ||. . | . | .||  .| ..
saGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 5823-6079 1.9e-41 136.8 In-house 13-258 (267) alignment 
Range on Protein: 5823-6079
Range on HMM: 13-258/267.0
EQFKNLYDEEKPCDVGKSNENKALNRLKNITVYDDNRIILTplshlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLk
|. |.. |..  .    ...|.. ||| .   |||.|.||      . . ||||| .|.||   ..|| ||.|.| |  ||. .| ...   ||.|||  
elikkisdtsstisqsiaeknqernrlddnlpyddtrvilr.....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv.

egGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNwslSKGTILVHCSA
  .. . |..||    . |..  . |     .   |  |  | . ...||.   ||  |.      .  |     |  | .  ..|       ..|.||.
..ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlen...gnrPlvvacsd

GVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEE
||||.| |. .|  ||.||.| |.||   . ..|.||. .|.....|...|. | | 
GvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0049772 (Phosphotyrosine protein) phosphatases II 5832-6078 2.2e-40 134.7 In-house 35-278 (314) alignment 
Range on Protein: 5832-6078
Range on HMM: 35-278/314.0
EKPCDVGKSNENKALNRLKNITVYDdNRIILtPLSHLECqTEYINANFVDGYsssKKFITTQGPMKDTLVDF----------WRLI--WQERPVSIVM--
|. . |..  .|.  || ..|  .| || || |  . .  . ||||..|||.   .||| ||||.. |.|||          ||..  .. ..  |||  
eltilvadlflnrdknryldilpad.nrvil.pglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsr

-------------------LTKLKEGGkskcRQYWPNSTSEVKefgpfnvilqntqtypdL-------FirklsitiqdessdSHTLIQYQLTSWPDqGV
                   |..| ..|     ....    . |                         |              ... |.|  . .|| | 
devladelsrLdaAlgKtpllildgng....neptaadlellk.................eelydpelf..............erlgikylripvpD.gs

PDYATSFMSLYrRVINNWsLSKGTILVHCSAGVGRTGVFIAVDIALEQAKkekvVDIAGIVNRLRQQRM-----KMVQSLDQYLFLHDALLE
..    | ... ..|...   .| .||||.||.||||.|..... . . .    |... .....|..|.      ....|.||.| ..||||
aplledfdefl.efieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 5832-6080 3e-40 133.1 In-house 32-277 (307) alignment 
Range on Protein: 5832-6080
Range on HMM: 32-277/307.0
EKPCDVGKSNENKalNRLKNITVYDDNRIILTplsHLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQ
  . .  ..| .|  || ... . | .||...        ..|| ||..      |||| .|||...|  .|| .. ||.  |..|| |. | .| ||.|
gvtveafsantdk..nryqdvkcqdkgrivvk...fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceq

YWPNSTSEVKEFGP--FNVILQN---TQTYPDL-FIRKLSITIqDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNwslsKGTILVHCSAGVG
|||    . . ||     . ..|    .  ||  .|   .. . | ...| |. ..| . |||.|||.   . . |   |  .    .  ..||||||||
ywpleegqklvfgeapntisvanlgakklapdedlinvttlkv.dwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhcsaGvG

RTGVFIAVDIALEQA-KKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEI
|.|  .|. .  ..  . .   |.  .|. ||.||   .|.  |||.||  |||  
rsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 5838-6078 3e-40 132.9 In-house 43-285 (305) alignment 
Range on Protein: 5838-6078
Range on HMM: 43-285/305.0
GKSNENKALNRLKNITVYDDNRIILTPlshlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNST
 |  ...  || |..   |.||. | .        ||| ||.|   . .|.|| || |...|  ||| . .|..  .| || .|.| |  || .|..   
fkeaqeagknrykdvgcldnnrvkleg....pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd

SEVKEFGP----FNVILQNTQTY-----PDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLyrrvINNWSLSKGTILVHCSAGVGRTG
 .| ||        | .. ..|.      .  ...  ..|.   ....   .|    |||.|||   .. . |    ...   ||| | ||||||.||||
kdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel....lekarpskgpivvhcsagigrtg

VFIAVDIALEQAKKEKVV-DIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
  . ..  |.|    ... |   |....|.|| . .|. .||||.|. .|.
svvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_PTPN9_pd Subfamily PTPN9 6109-6353 6.9e-40 131.9 In-house 16-286 (297) alignment 
Range on Protein: 6109-6353
Range on HMM: 16-286/297.0
TKLEAQYNLLYQLTPDpNDVDCKSAKAHASKNRSNNYLPPDKFIVALKETDG-----YINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVII
  |  .|  . . ..    ...   .|  .||| .. |  |.  | |...|.     ||||.... |. |.||| .| |...||.|||.|. . .| ||.
rGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

MLCG--E--EDCCYQYWI----DSMTYDEFVVKVSSETNASGYIERKLKVS--IDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSG-----
|     |     | |||     .|. . .. |.. .  . . | .|.|...   ..|||.|   |.. ||  || .. ...|.....||||| .      
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelg

-------KKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
       .. |.|||||  . |.| .... |.|.. . .|.|||... | ||  .  .| | |||.  |  |
dewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 6136-6359 1.8e-39 130.4 In-house 20-266 (270) alignment 
Range on Protein: 6136-6359
Range on HMM: 20-266/270.0
HASKNRSNNYLPPDKFIVALKET-----DGYINASYLNSYRGK-NAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG----EEDCCYQYWIDSM-----
..  ||... ||  .  | |.|        |||| |.. . |. ...| |..|...|...||.||.. ||. |.|. |      . | .||  .      
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-TYDEFVVKVSSETNASGYIERKLKVSIDKESRSVLQLQVTDWPQDGVVREPS------TILKIIDEVREKQKSGKKG-PVVVHCSDTVSRSGVYCSVSI
 .. .  | ..||....||| ..|..  . |.| ..  . ..||..||.||.        .||.. .||. .|. .|. |..||||. | |.|.   . |
ledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDi

ALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
|..  . .. ||| .. ..||. ..  . . |||. .| .| .| ..
avrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
0046846 (Phosphotyrosine protein) phosphatases II 5870-6077 2.1e-39 130.4 In-house 10-170 (176) alignment 
Range on Protein: 5870-6077
Range on HMM: 10-170/176.0
CQTEYINANFVDGYssskKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNstseVKEFGPfnvilqntqtypdlfirklsitiq
    |||||...|.    ..|.||||. .|| ||........   .|.||...| |. || .|||     ....|                         
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi........................

dessdshtliQYQLTSWPDQGVPDYaTSFMSLYRRVINNWSlSKGTILVHCSAGVGRTGVFIAVDialeQAKKEKVVDIAGIVNRLRQQRM-KMVQSLDQ
          ||. . ||| ||||. . ...|.. . .  . ..|..|||||||.||||...| .      ..|| ...  .. ..|.||. ..||. .|
..........qylhlpwpDhgvpdl.elllellefirealk.eggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

YLFLHDALL
| ||....|
yrflyefel
0043147 (Phosphotyrosine protein) phosphatases II 5872-6073 3e-39 129.9 In-house 5-154 (172) alignment 
Range on Protein: 5872-6073
Range on HMM: 5-154/172.0
TEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLkeggkskcrqywpnstsevkefgpfnvilqntqtypdlfirklsitIQDE
. ||||...|.|   ..|| ||||.  || ||||.....    ||.||.|                                                | 
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydp

SSDSHTLIQYQLTSWPDQGVPdYATSFMSLYRRVIN-NWSLSKGTILVHCSAGVGRTGVFIAVDIALeqakkeKVVDIAGIVNRLRQQRMKMVQSLDQYL
.  ... |||. ..|||.|||  .  ...... . .     ..|..||||||||||||...| .. |      . ...  .|. .|..|...||. .|| 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FLH
||.
fly
subfamily_PTPN14_pd Subfamily PTPN14 6100-6360 3.4e-39 129.6 In-house 14-299 (300) alignment 
Range on Protein: 6100-6360
Range on HMM: 14-299/300.0
KKNNRKTNSTKLEAQYNLLYQLTPdPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKE----TDGYINASYLNSYRG--KNAFILAQSPMENTVRDFWKM
|  ..| ...|. ..|. . .      .... . .  |.||| .. || ..  | |.     ..|||||| ..   |  .  .| ||.|.|.||.|||.|
kilekkleegkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqm

IVDCKVSVIIMLCGE----EDCCYQYWIDS------MTYDEFVVKVSSETNASGYIERKLKVS--IDKESRSVLQLQVTDWPQDGVVREPSTILKIIDE-
. . .|..|.||  |     . ...|. ..      .....| |     .... .| ..||.     || |.|. || ||||..|| ..... |. ..| 
vWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeev

--VREKQKSGK-----KGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQTT
  ||.| .| .     | ||.||||. | |.||   . . ..  . . ..|. .| . ||. .   . || ||. .|.|.  ||. .
qsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 5835-6082 8.1e-39 128.3 In-house 27-272 (285) alignment 
Range on Protein: 5835-6082
Range on HMM: 27-272/285.0
CDVGKSNENKALNRLKNITVYDDNRIILTplshlECQTEYINANFVDGYS-SSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYW
|     . |  |||  .. . .. |..|      . . .|| |...         .||||||. .|| |||..|.||.   ..||  | |||  ||  |.
ctytayeanpdlnryadvrcieetrvvlk.....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PNSTSEVKEFGPFNVILQNTQT--YPDLFIRKLSI-TIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNwSLSKGTILVHCSAGVGRTGVF
|.   || .|| ... | . .        .  |..   .| ||.   . . |.  ||||  |. |  .. ||. | .     .  | ||||||||||  |
peklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrtatf

IAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIIC
. .| |  .  ..  ...  ||  .|  |.. |||  |.|||.  |.| .| 
vgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig
0049260 (Phosphotyrosine protein) phosphatases II 5879-6074 5e-38 125.5 In-house 1-144 (152) alignment 
Range on Protein: 5879-6074
Range on HMM: 1-144/152.0
FVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWpnstsevkefgpfnvilqntqtypdlfirklsitiqdessdshtl
|.|||  ...|| ||||.  || ||||....     |||||.| | || || ||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

iQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALeqakkeKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHD
 ||. . ||| |||| .  .. |.. .   .  ..|..||||||||||||...| .. |      . |..  .|...|..|...|.. .|. ||..
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 5820-6078 1.5e-37 123.8 In-house 12-267 (281) alignment 
Range on Protein: 5820-6078
Range on HMM: 12-267/281.0
AFEEQFKNLYDEE--KPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVM
 |...| ||  .     | | .   |.  ||  || . |  |. |      .  |.|| ||..      . .| |||| |.|  ||||.||||   .|||
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

LTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESsdsHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNwSlskGTIL
| .. |  . || .|.|  .  . .|  . |  ...     |   .| .. . |.   . . ..    |||  ||. .  .. . |..    |      .
lcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyeget...rlithwlwkewpdwqvpessevmlkilrkirar.s...tppv

VHCSAGVGRTGVFIAVDIALEQAKKE-KVVDIAGIVNRLRQ-QRMKMVQSLDQYLFLHDALLE
.||||||||.| ..||.|||.  .    . ||  || .||   |   ||.|.||...   ||.
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 5842-6079 7.1e-37 121.7 In-house 54-288 (305) alignment 
Range on Protein: 5842-6079
Range on HMM: 54-288/305.0
ENKALNRLKNITVYDDNRIILTPLShlecQTEYINANFVDGY-SSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEV
 ... || ... . | . . |   |     ..|| ||.|       |.|| .|||. .|. .|| .. |..   |||| |  | || || |||| .  | 
iaitknryqdvpcqdqsavkldkps....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

KEFGPFNVILQNTQTYPDLFIRKLSITIQDESS---DSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVinnwSLSKGTILVHCSAGVGRTGVFIAVDIAL
.|.    |. . . . |     .. ||. . .    .. .. . | | |||.|||    . . |   .      ||  |.||||||.||||  .|..  |
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai....rgskvpivvhcsagigrtgtivaieyil

EQAKKEK-VVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEE
|.  ..| .  .  .|. ||.||   .|.  ||||.|  .|. 
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 6095-6353 2e-35 117.1 In-house 10-275 (439) alignment 
Range on Protein: 6095-6353
Range on HMM: 10-275/439.0
AVERLKKNNRKTnstkLEAQYNLLYQLTPDPNDVDCKSAKA-HASKNRSNNYLPPDKFIVALKETDG-----YINASYLNSYRGKNAFILAQSPMENTVR
 ||.|.||...     ..  .. .    || . . .  |.    .||| ..  . |   |.|.|. |     |||| |.. |  .. .| .| | ..|. 
hvekldknkqei....fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWKMIVDCKVSVIIMLCGEEDcCYQYWI--DSMTYDEFVVKVSSETNASGYIERKLKVSID----KESRSVLQLQVTDWPQDGVVREPSTILKIIDEVR
|||..... |.. |.||.   .  |.||   . . | . .|.|  . .   |. | .||  .    .  |.|||.. . ||.  |  . | .|. .  . 
dfwrlviekktvtivmltnlve.sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrain

EKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
  . . . ||||||||  | |.|   .. ||||| ..|  ||.  . | ||. .   . .| ||  ||. |
sandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
0051429 (Phosphotyrosine protein) phosphatases II 6158-6358 2.1e-35 118.1 In-house 3-226 (272) alignment 
Range on Protein: 6158-6358
Range on HMM: 3-226/272.0
TDGYINASYLNSYRG---KNAFILAQSPMENTVRDFWKMiVDCKVSVIIMLCGEE----DCCYQYWI--------------DSMTYDEFVVKVSSETNAS
..|||||.... | .   ........ |...|..|||..  . ....|..|..||    . |..||                ...|  ..|.. ||.. .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERKLKVS---IDKESRSVLQLQVTDWPQDGVVREPstILKIIDEVREkqksgkKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVD--------V
 || |.| ..     .|.| |..|. |||| .|| .|.  .|........      .|||.||||  ..|.|... . . |.. ..| .||        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQ
... . ||.  |||. | |||  .|...  .| 
eeaveelraqrpgavqteeqylflyeallellr
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 6108-6352 3.1e-35 116.5 In-house 5-254 (267) alignment 
Range on Protein: 6108-6352
Range on HMM: 5-254/267.0
STKLEAQYNLLYQLTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKET-DGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLC
 ...| ...|. ..... . . .  |.  . .|| .. || |. .| |... . ||||||...|. |||||. | |..||. ||...| | ||.||..| 
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivllt

-GEEDCCYQYWIDS----MTYDEFVVKVSSETNASGYIERKLKVSIDKESRSVLQLQV-TDWPQDgvvREPSTILKIIDEV-REKQKSGKKGPVVVHCSD
   .|   ..|         |....|. | | .   |    |.. . .||   . |     |  .    .    || .  .  ..|      |.||.|||
kvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnin...tnnkpylkplfgilaknqlengnrPlvvacsd

TVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDV
 | ||| .  .   ||.   |||.|.|.  . .|  ..| . |.|.|  |...
GvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel
0041856 (Phosphotyrosine protein) phosphatases II 6138-6356 1.8e-34 114.3 In-house 3-170 (182) alignment 
Range on Protein: 6138-6356
Range on HMM: 3-170/182.0
SKNRSNNYLPPDKFIvalkeTDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCgeedcCYQYWIdsmtydefvvkvssetnasg
.|||  ..||.|  .        ||||... ...  . ||..| |. .|| ||..|. . ....|..|.     ...||                     
dknrysdilpydhsr.....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp....................

yierklkvsiDKESRSVLQLQVTDWPQDGVVRePSTILKIIDEVREkqksgKKGPVVVHCSDTVSRSGVYCSVSIALEQcnaeGvVDVFQVTKALRRSKP
          ... | ..|.. . || .||   ....|..|.||.|     ..|||.||||  |.|.|...   . ...    | |..... | .|. .|
..........ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRp

GAITTLEQYTSIYDVVDLY
|...|..||  ..... ..
gmvitpnqyfflqlallel
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 6122-6353 2e-34 113.6 In-house 29-232 (392) alignment 
Range on Protein: 6122-6353
Range on HMM: 29-232/392.0
TPDPNDVDCKSAKA--HASKNRSNNYLPPDKFIVAL-----KETDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG--EEDcc
 |.|.  . ..|.      ||| .| || |.  | |        . |.||||..|.  ..|.| .|.|   .. |||.|. . .|. |.|.    | |  
lpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..

yqywidsmtydefvvkvssetnasgyierklkvsIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKqkSGKKG-PVVVHCSDTVSRSGVYCSVS
                                    .. |.| | ..|.||...| .  |..||.| ||. .   |.   |...|||  | |.||  |. 
..................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad..fGqythpliihcsagvgrtgvvisid

IALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
  . ...   .||||..   .|| .|  . | |||. ||  |
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 5842-6084 5.1e-34 112.6 In-house 42-275 (288) alignment 
Range on Protein: 5842-6084
Range on HMM: 42-275/288.0
ENKALNRLKNITVYDDNRIILTplshlECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVK
.| . .| .|.   |  |. |.     .    ||.|| |      ...| .| |.. |.  .|... ..    ||||..| | || |  .|.|    |  
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

EFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVinnwSLSKGTILVHCSAGVGRTGVFIAVDIALEQAK
 .| .  . .. ..  |  ..   . |. |  ..  . .  |  |.|.|||.   |.. |  ..       .  |.||.|||||||| .| . ||||...
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslr

KEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGK
 .  . |  ....||..|.| .|.  |||..|  .|||..  |
lddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 6134-6359 5.7e-34 112.2 In-house 36-279 (287) alignment 
Range on Protein: 6134-6359
Range on HMM: 36-279/287.0
KAHASKNRSNNYLPPDKF--IVALKET--DGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGE-ED---CCYQYWIDS---MTY
 | ..|||  . || |.   ... .      |||| |. ||. ..||| ||.|.  ||||||..... .....|..  | |.    ||.|| .    |  
laavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

DEFVVKVSSETNA-SGYIERKLKVsIDKES---RSVLQLQVTDWPQDGVVREPSTILKIIDEV---REKQKSG-KKGPVVVHCSDTVSRSGVYCSVSIAL
  . | . . ..    |  | |.. || |.   | | ||.. .||....      ... . .|    | .... . ||.|||..  . |||.. .. . .
GGysvvlldydikePeygvralrl.idletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

EQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
.. .  | ||| .|   ||  . . . .  |.  .|. .  | .|
srledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_PTPN1_pd Subfamily PTPN1 6118-6347 7.6e-34 111.7 In-house 12-261 (290) alignment 
Range on Protein: 6118-6347
Range on HMM: 12-261/290.0
LYQLTPDPNDVDCKSAKAHASK--NRSNNYLPPDKFIVALKETD-GYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLC----GEED
. ... . .|.....|| .. .  ||  .  | |.  . |...|  ||||| ..  . |  .||.| |. |||  ||.|. . |   ..||      |. 
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

CCYQYWI-----DSMTYD--EFVVKVSSETNASGYIERKLKVSI--DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQ-KSGKKGPVVVHCSDT
 |.|||      ......  .. ||. || . | |. |.|..     .|.|..|.   | ||  || . |.. || . .|||    | ..||.|.|||  
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VSRSGVYCSVSIALEQCNAEGV---VDVFQVTKALRRSKPGAITTLEQYT
. ||| .| |   | . ....    ||. .|  .||. . | | | .|  
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlr
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 5875-6071 1.7e-33 110.7 In-house 78-272 (301) alignment 
Range on Protein: 5875-6071
Range on HMM: 78-272/301.0
INANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESS-
| ||...    ...||.||||.|.|  ||| .. |     ||||..  |  ..||..| | ..||  . | |.. ..|...  .  | | .. ..| .  
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

-DSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVinnwSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLF
 ...|.. || ..|.|.|||   .  . |   |      |.  |.||||||.||.  ||. ..   . . .. ....  ...||..| . ||   |  .
fatrtvthyqysewtdrgvPkshaelfdlmelv....kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 5844-6077 2.7e-33 109.8 In-house 53-287 (310) alignment 
Range on Protein: 5844-6077
Range on HMM: 53-287/310.0
KALNRLKNITVYDDNRIILTplSHLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPnSTSEVKEF
   ||  .. . |. |. |.         .|| ||.|      . || .|||.. |..||||.|.|||  ||..| |  | |. ||  ||| |    . .
mhknrysdvvcldtsrvklk..idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp.slgvtety

GPFNVIlQNTQTYPDLFIRKLSITIQ------DESSDSHTLIQY---QLTSWPDQGVPDYATSfmSLYRRVINNwsLSKGTILVHCSAGVGRTGVFIAVD
|   |  . ...  .. | .|..|.       ||       ..    .   |||.||||      .. .|.. .  . .|  .||||||..|..| .|..
gcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch..tvpqrllaq..vrhgpcvvhcsagkdrlyvvvalk

IALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALL
........ . ||.  ..  |...|.. .|.  |||...   .
lkidkldrglkvdaeevktellksraiciqtelqyliidrvri
0051082 (Phosphotyrosine protein) phosphatases II 5872-6077 3e-33 109.9 In-house 3-150 (151) alignment 
Range on Protein: 5872-6077
Range on HMM: 3-150/151.0
TEYINANFVDGYssskkFITTQGPMKdtlvDFWRLIWQERPVSIVMLTKLKEGGksKCRQYWPNSTsevkefgpfnvilqntqtypdlfirklsitiqde
. |||...|.|.     .. ..||.     ||..|....   .||.|....| |  .| .|.|.                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

ssdsHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINnwsLSKGTILVHCSAGVGRTGVFIAVDIALEQakkekvVDIAGIVNRLRQQRMKMVQSLDQYLF
    ..........|||.|.|..  ..... . ...    ..| .|||||||.||||...|... |..      |... ... .|..|. .||. .|.||
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

LHDALL
.. |||
qlfall
subfamily_ptpA1_pd Subfamily ptpA1 5808-6037 3.2e-33 110.1 In-house 13-253 (418) alignment 
Range on Protein: 5808-6037
Range on HMM: 13-253/418.0
LAAHIATCYdsnAFEEQFKNLYDEEKPCDV--GKSNENKALNRLKNITVYDDNRIILTPLSHLECqTEYINANFVDGySSSKKFITTQGPMKDTLVDFWR
|  ||   .     .|.|. | .   | .   |  . | . ||  ||   .  |. |  .   |  ..|||||..|| .  |.|| ||||. .|. ||||
lknhikcih...kikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkeg.sdyinanyidg.aypkqfictqgplpntiadfwr

LIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSE---------VKEFGPFNVILQNTQTYPD--LFIRKLSITIQDESSDshtLIQYQLTSWPDQGVPDY
..|..|   ||||..  |  . || .|||.              . || ..| | .    |.  .  |.. .|.. |. |   . |||   |||. .||.
mvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrd...itqyqyegwpdhnipdh

ATSFMSLYRRVINNW------SLSKGTILVHCSAGVGRTGVFIAVDIAL
.  |  | . . |        |  .  |.||||||||||| | .  | .
tqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 6138-6352 3.6e-33 109.7 In-house 5-234 (237) alignment 
Range on Protein: 6138-6352
Range on HMM: 5-234/237.0
SKNRSNNYLPPDKFIVALKETD---GYINASYLNSYRGK-NAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG----EEDCCYQYWIDS---MTYDEFV
 |||  |    |.  | || .     ||||.||... |  . .| || |.|..  |||.|. . | |||.|| |    .|  |..|| ..    .|  . 
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvlt

VKVSSETNASGYIERKLKVSID---KESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKS-GKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGV
| .  . . | |  | | .|     || | . | | | ||. || .. ...|..  .. .. .   . || ..|||  | |.|..  .   | |.. . |
vslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkv

VDVFQVTKALRRSKPGAITTLEQYTSIYDV
||...  ...   .|  | | .||  |...
vdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_PTPRN_pd Subfamily PTPRN 6105-6353 9.2e-33 108.2 In-house 25-288 (297) alignment 
Range on Protein: 6105-6353
Range on HMM: 25-288/297.0
KTNSTKLEAQYNLLYQLTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKET-----DGYINASYLNSYRG-KNAFILAQSPMENTVRDFWKMIVDCK
 .| ..||.... | .   .|.  .  .|.  ..||||.. || |. .| |||.     . ||||| .      . |.| .|.|. .|| |||.|. .  
lknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

VSVIIMLCGEED----CCYQYWID--SMTYDEFVVKVSSET-NASGYIERK--LKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVrEKQKSGK
| ||..|.  |.     |..|| |  | .|. . |.. ||   .  |. |   ||    .|.|.| |.    ||. ||  .. ..|.    | .|   |.
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkv.nksyrGr

KGPVVVHCSDTVSRSGVYCSVSIALEQCNaEGV--VDVFQVTKALRRSKPGAITTLEQYTSIYDVV
  |.|||||| . |.|||. . . |.. .  ||  .|.    . ||  .|| . | .|.  .. .|
scpivvhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfefaltav
PTPc_DSPc_SM00012 5978-6078 1e-32 107.8 In-house 2-105 (105) alignment 
Range on Protein: 5978-6078
Range on HMM: 2-105/105.0
LIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSK--GTILVHCSAGVGRTGVFIAVDIALEQAKKE-KVVDIAGIVNRLRQQRMKMVQSLDQYLFLHD
. .|. |.|||.|||....|...| | | .| . |.  . ..|||||||||||.|.|.||.|.| .|| | |||  ||..||.||..|||...|||||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
0036282 (Phosphotyrosine protein) phosphatases II 6159-6351 2.3e-32 107.5 In-house 2-164 (174) alignment 
Range on Protein: 6159-6351
Range on HMM: 2-164/174.0
DGYINASYLNSYRGKNAFILAQSPMEntvrdFWKMIVDCKVSVIIMLCGEED----CCYQYWIDsmtydefvvkvssetnasgyierklkvSIDKESRSV
. |||||.|. ..  . .|. | |..     ||.|. . ......||. |.      |..|| .                             . ..|..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...........................lredlerlg

LQLQVTDWPQDGVVREPStILKIIDEVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNaEGVVDVFQVTKALRRSKPGAITTLEQYTSIYD
.|.. . || .||   .  .|.....|.| ......|||.||||  |.|.|. .   . | .   |..||.... ..||. .||...| .||  .|.
iqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0044763 (Phosphotyrosine protein) phosphatases II 5855-6076 1e-31 105.3 In-house 2-167 (178) alignment 
Range on Protein: 5855-6076
Range on HMM: 2-167/178.0
YDDNRIILTPLSHLECqTEYINANFVDGYssskKFITTQGPmkdtlVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSevkefgpfnvilqntq
.|..| .|..|..||. ..||||......     ......|     .|...|....   .||.||. .|.|. || .||| ...                
ldrtrvllsnlegler.sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

typdlfirklsitiqdessdshtlIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQakkeKVvDIAGIVNR
                        |||. . .|| ||||    |. ... . .  . ..|..||||||||||.|...| .. ...    .. ..  ....
........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaiel

LRQQRMkMVQSLDQYLFLHDAL
.|..|. .|.. .|. .|..  
vrerRp.ivpnpgqlrqLyefe
0043147 (Phosphotyrosine protein) phosphatases II 6158-6351 1.3e-30 101.8 In-house 4-155 (172) alignment 
Range on Protein: 6158-6351
Range on HMM: 4-155/172.0
TDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEedccyqywidsmtydefvvkvssetnasgyierklKVSIDKESRSVLQL
 . |||||||. |.  . ||  | |. ||. |||.|. . ....|..|...                                    .  ....|...|.
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...................................lydpellerlgiqy

QVTDWPQDGVVrEPSTILKIIDEVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALeqcnaeG-VvDVFQVTKALRRSKPGAITTLEQYTSIYD
. . ||  ||   .. .|.... ..|..   ..|||.||||  |.|.|. .   . |        . ..... . .|. .|||... .||  .|.
lylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 5818-5993 3.1e-30 100.1 In-house 6-181 (297) alignment 
Range on Protein: 5818-5993
Range on HMM: 6-181/297.0
SNAFEEQFKNLYDEEKPCDVGKSNENKA--LNRLKNITVYDDNRIILTplsHLECQTEYINANFVDG--YSSSKKFITTQGPMKDTLVDFWRLIWQERPV
 .. |..   |.|| .. .   .. | .   || ..|  .||.|. |        ...||||..|      .  |.| .|||...|. |||.|....   
rkeleaekdllldeargesfssakrnsslrknryrdilatddtrvkll...rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvr

SIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNV--ILQNTQTYPDLFIRKLSITIQdesSDSHTLIQYQLTSWPDQGVPD
 |||..||.|.|..||  |||..  | .. | . |  . . .. .  ... .| .  .   |.|  .   |  |||| ||| 
vivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvps
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 5886-6073 1e-29 98.2 In-house 4-197 (199) alignment 
Range on Protein: 5886-6073
Range on HMM: 4-197/199.0
SKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHT-LIQYQLT
 ...|.|| |...|. |||...|.     |||.   .   ..    ||| . | . ..| ..|  .   | ||  |  | .| .  .  |   . .||.|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDQGVPDYA--TSFMSLYRRVINNWSLSKG-TILVHCSAGVGRTGVFIAVDIALEQA--KKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLH
|| ..  |. |    |.   | | ...   |   ..|||| | | ||||.|.|| .      |  |||.  . .|||| |  .. ||..| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 5886-6073 1.2e-29 97.9 In-house 3-196 (198) alignment 
Range on Protein: 5886-6073
Range on HMM: 3-196/198.0
SKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDESSDSHT-LIQYQLT
 ...|.|| |...|| |||...|.     |||.   .   ..    ||| . | . ..| ..|  .   | ||  |  | .| .  .  |   . .||.|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDQGVPDYA--TSFMSLYRRVINNWSLSKG-TILVHCSAGVGRTGVFIAVDIALEQA--KKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLH
|| ..  |. |    |.   | | ...   |   ..|||| | | ||||.|.|| .      |  |||.  . .|||| |  .. ||..| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 5974-6115 5.1e-29 95.9 In-house 87-229 (440) alignment 
Range on Protein: 5974-6115
Range on HMM: 87-229/440.0
DSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNW-SLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFL
.|.|| ||.  .|||.||| .|   . . . | ..    ..| .|||||||.||||| ||||  | .||.   .||  ..| .|..| .|||. .|| |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDALLEEIICGKTEIPIENYSLAVERLKKNNRKTNSTKLEAQY
|.|.|| ..|| | |  .. .  ||...  | .|. . |. ..
heavlegllcgdtliledditerveqiqwpnphtdksplqqef
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 6165-6352 7.3e-29 95.4 In-house 227-433 (440) alignment 
Range on Protein: 6165-6352
Range on HMM: 227-433/440.0
SYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEED-CCYQYW---IDSMTYDEFVVKVSSETNASGYIERKLKVSIDKESRSVLQLQVT
  .. |  ||||| .| |.. || |||... | ..| ||||   .|  |  ||     |.|.  | |      |      | |..   .|   . |..| 
qefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevq

DWP----QDGVVREP---STILKIIDEVR--------EKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQ
 ||     |||  .     ..|...| .|        |. . |   |..|||   .  |||.|.|   ||| | .| .||||  . || |.|  . || .
twptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltd

YTSIYDV
|   | .
yllcykl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 6139-6350 9.6e-29 95.2 In-house 10-233 (239) alignment 
Range on Protein: 6139-6350
Range on HMM: 10-233/239.0
KNRSNNYLPPDKFIVALKE-----TDGYINASYLNSYRGK-NAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG----EEDCCYQYWIDSM-TYDEFVV
|||  | .  |.  | |..        |||||||  | |  .|.| .|  .| .  |||.|. . .  ||.|| |     .  |.||| ||   | .. |
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv

KVSSETNASGYIERKLKVSI--DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGKKgPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDV
 .      . || | . .|   . | | | | ..| ||. || .  ...| .  .. .    | . | |.|||  | |.| .  .   | |.. .  ||.
tlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar.pwvihcsagvgrtgaflvidamlrqakkqktvdi

FQVTKALRRSKPGAITTLEQYTSIY
|.  ||.|  .|  . | |||  |.
fnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 6139-6350 1.1e-28 95.0 In-house 11-234 (239) alignment 
Range on Protein: 6139-6350
Range on HMM: 11-234/239.0
KNRSNNYLPPDKFIVALKE-----TDGYINASYLNSYRGK-NAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG----EEDCCYQYWIDSM-TYDEFVV
|||  | .  |.  | |..        |||||||  | |  .|.| .|  .| .  |||.|. . .  ||.|| |     .  |.||| ||   | .. |
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv

KVSSETNASGYIERKLKVSI--DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGKKgPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDV
 .      . || | . .|   . | | | | ..| ||. || .  ...| .  .. .    | . | |.|||  | |.| .  .   | |.. .  ||.
tlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar.pwvihcsagvgrtgaflvidamlrqakkqktvdi

FQVTKALRRSKPGAITTLEQYTSIY
|.  ||.|  .|  . | |||  |.
fnyvkairedrphmvqtseqyvfih
subfamily_egg_pd Subfamily egg 5831-6089 3.8e-28 93.0 In-house 28-282 (307) alignment 
Range on Protein: 5831-6089
Range on HMM: 28-282/307.0
EEKPCDVGKSNENKALNRLKNITVYDDNRIILtPLSHLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGgkSKCR
.|..     |..|.   | | .   |  |. |  | .     ..| || |.|     .|| .| |.|.|  ||||...||.   |||||  ||    .| 
deislttaasdnnlekarskrvhckdssrvkl.elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPNSTSEVKEF--GPFNVILQNTQTYPDLF--IRKLSItIQDEssdshtLIQYQLTSWpdQGVPDYATSFMSLYRRVINNWSLSKGTIlVHCSAGVGR
 |||.. |.   .  | ...   . .  .| .  . || . .  .        .  |  |  ||  ....   | .| .     ||| .. |..  || .
yywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgd......deerflehw..qgdvnnssdvysplrvlrklrnlskpvv.vqdilGvsk

TGVFIAVDIALEQAKKEKVV--DIAGIVNRLRQQRMKMVQSLDQYLFLHDALL---EEIICGKTEIPI
.....|..||| .  .  ..   .   |  ||..|   |.|  .|||..  .|    ..|    |. .
aatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 6135-6352 8e-27 88.6 In-house 55-278 (290) alignment 
Range on Protein: 6135-6352
Range on HMM: 55-278/290.0
AHASKNRSNNYLPPDKFIVALKET-D-GYINASYLNSYrgKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGE----EDCCYQYWID----SMTYDE
..  |||  .    ||  | ||.  |  |. | |..    |  |||.| ....|| |.|.|... ||..|.|||         | ||. .     .|. |
tefkknrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

FVVKVSSETNASGYIERKLKVSIDKES---RSVLQLQVTDWPQDGVVREPSTILKIIDEVREKqksgkKGPVVVHCSDTVSRSGVYCSVSIALeQCNAEG
. |  | |..    | .|.    ||.|     .  |..  ||.  |     ..|...  .|.       ||||||||  . |.| . .. ..| |.  .|
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievgl.qilldG

-VVDVFQVTKALRRSKPGAITTLEQYTSIYDV
  .|. .. .|||.|. ...    ||  . ..
keldlldlvralrnsrlnsvqvdiqylalvei
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 5822-6077 1.4e-26 87.6 In-house 29-282 (302) alignment 
Range on Protein: 5822-6077
Range on HMM: 29-282/302.0
EEQFKNL----YDEEKpCDVGKSNEnkALNRLKNITVYDDNRIILTplshlECQTEYINANFVDGYSSSKKFITTQGPMKDTL---VDFWRLIWQERPVS
...||..     | || | . |.|   . |. ... ..|.|...|.     ... .|.||  |.  . ... | .| | .|.     .|||...||. ||
kkefkkidtmkvdlek.Ckafkknl..kknqsedvpildsnlvkle.....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

IVMLTKLKEGGKsKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFiRKLSITI-QDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSLSK
.|.| . .|  |    ...|. . . ||.| . |  .  .   .    ...| .  .. |.|     | || |... ||.  .. .     | .. . ..
vvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikad

GTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALL
 ....    |.|| |.|... .|.|. .|.| . |. ||. .|.|| ..|.||.|| .|. |||
entvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 5844-6081 3.1e-26 86.8 In-house 44-277 (312) alignment 
Range on Protein: 5844-6081
Range on HMM: 44-277/312.0
KALNRLKNITVYDDNRIILTPlshleCQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKeF
| |||  || ..|  |. |.       .  || ||||   .  ..|..||||...| . ||.|      .||..|. . | |  || .|  .  . |. .
kdlnrypniqcwdrgrftlag.....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd.l

GPFNVI-------LQNTQTYPDLFIRKLSITIQDESSDShTLIQYQLTSWPDQGVPDYATSFMslyrRVINNWSLSKGTILVHCSAGVGRTGVFIAVDIA
    |            ..   .  | | . ..    .|  | .|| .||||.|.||   . .    |..      |  .. |||||||||| .. ..  
edhrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtal....rllsavkkdkkpviahcsagvgrtgtlaliesm

LEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEII
.   .. .  ..  .   ||..| . |. . ||..   ..|| . 
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
0046846 (Phosphotyrosine protein) phosphatases II 6161-6357 9.9e-26 86.0 In-house 14-173 (176) alignment 
Range on Protein: 6161-6357
Range on HMM: 14-173/176.0
YINASYLNSYRgknaFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEEDC----CYQYWIDSMTYDEfvvkvssetnasgyierklkvsidkesrsvlQ
||||... ..|    .|  | |...|. ||..|. . .......|. | .     |..|| . ....                                |
yinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............................q

LQVTDWPQDGVVREpSTILKIIDEVREKQKSGkkGPVVVHCSDTVSRSGVYCSVSialeQCNAEGVVDVFQVTKALRRSKP-GAITTLEQYTSIYDVVDL
 ....||  ||    . .|......|| .|.|  |||.||||  ..|.|...        .  |  ..|... . .|. .| ||..| |||  .|... |
ylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefell

YL
.|
ll
PTPc_DSPc_SM00012 6254-6353 7.4e-25 82.6 In-house 2-103 (105) alignment 
Range on Protein: 6254-6353
Range on HMM: 2-103/105.0
VLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGK-KGPVVVHCSDTVSRSGVYCSVSIALEQCNAE-GVVDVFQVTKALRRSKPGAITTLEQYTSIYD
| ....|.||. || .|.. ||.....|.....  . ..|||||||. |.|.|... ..|.|.|...| . ||.||. |.||...||...|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VV
..
al
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 6109-6357 1.6e-24 81.5 In-house 16-277 (307) alignment 
Range on Protein: 6109-6357
Range on HMM: 16-277/307.0
TKLEAQYNLLYQLTPdpNDVDCKSAKAHASKNRSNNYLPPDKFIVALKE---TDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIML
..|  ... | . ||  . |  .. .| . ||| ..    ||  . .|    .  || | ||      . || || |.|||. .|| |... ||  .|||
qalvdefrvlakktp..egvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

CGEED----CCYQYWID----SMTYDEFVVKVSSETN-------ASGYIE-RKLKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKsgk
|   .     | |||       ... |    .| .            .|.  .|||   ..||.. .|| ..||. || .   | . ... || ..    
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn...

kgPVVVHCSDTVSRSGVYCSVSIALEQC-NAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYL
  |||||||  | |||   ..|.  ..  . .   |. .. . ||  .. || |  ||  .. |.  |.
..pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0049772 (Phosphotyrosine protein) phosphatases II 6132-6359 2e-24 82.3 In-house 42-282 (314) alignment 
Range on Protein: 6132-6359
Range on HMM: 42-282/314.0
SAKAHASKNRSNNYLPPDkFIVALK----ETDGYINASYLNSYrgkNAFILAQSPMENTVRDF----------WKMIV--DCKVSVIIM-----------
.  .. .|||. . || |   | |.    .. .||||||....   ..|| .| |.|.|| ||          |.|..  | .| .| |           
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LCGEEDCCyQYWiDSMTYDEFVvkvssetnasgyierklK-------VsidkeSRSVLQLQVTDWPQdGVVREPSTILKIIDEVREKqks
          |..       .. . ......                  .       .     .| ....  ...|  | .  .. ...... ..|    
rLdaAlgKtpllildgng.nep.taadlellk.................eelydpelf.....erlgikylripvpD.gsaplledfdeflefieea...

GKKGPVVVHCSDTVSRSGVYCSVSIALEQCNaegVvDVFQVTKALRRSKP-----GAITTLEQYTSIYDVVDLYLQT
 |.|||.|||.. ..|.|... . . . ...   | .. .. . .|.  |     |.| .||||  |....  ||..
dkggpvlvHCkaGkgRtgtfvvaaylmkllg...v.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 5849-6093 7e-24 79.5 In-house 24-257 (290) alignment 
Range on Protein: 5849-6093
Range on HMM: 24-257/290.0
LKNITVYDDNRIILTPLSHlECQTEYINANFVDgYSSSKKFITTQGPMKDT-------LVDFWRLIWQERPVSIVMLTKLKEGGKS----KCRQYWPNST
  ....  ..|..|        . .|| ||.|  ...  ..| || | ...       . .|| .. ||.  ..||| . .|  .      | .| |.| 
RlevpLveatrvvLkgygk.rfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesv

SEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDEssDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVInnwsLSKGTILVHCSAGVGRTGVFIAVDIAL
 |   |. ..|  ..  .  |. .|.| .. .||    .|.  ..| .| .  |..   ...|| . |      || ...|||  |. |  .. |.... 
geelkfkgltvkCkskekeddvetRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgy

EQAK-KEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLeeiicgkteipienyS
     ... | .. ... ||.|| ....|  .. |   ...                
Qkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...............l
0048076 (Phosphotyrosine protein) phosphatases II 5943-6077 1.3e-23 78.7 In-house 13-140 (145) alignment 
Range on Protein: 5943-6077
Range on HMM: 13-140/145.0
FGPFNvILQNTQTYPDLFIRKLSITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRRVInNWSLSKGTILVHCSAGVGRTGVFIAVDIALEqakk
.|..    .. ... || |. .     ...  ... |||. ..||| |||| .  ...... .  ..  ..| .||||||||||||...| .. |.    
lgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefie.ealkeggpvlVHCsaGvgRtgtlvaaylmll....

EKvVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALL
.. |..  .....|.||...|.. .|. ||....|
lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 6150-6353 1.3e-23 78.0 In-house 57-265 (281) alignment 
Range on Protein: 6150-6353
Range on HMM: 57-265/281.0
KFIVALKETDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG----EEDCCYQYWID----SMTYDEFVVKVSSETNASGYIER
|. .  |..  || | |. |   |  .||.| | ..|  |||.|| . . . |.|||     . . | .|.       . .|.. |.    |     .  
kvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvtt

KLKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQksgkkGPVVVHCSDTVSRSGVYCSVSIALEQCNAE-GVVDVFQVTKALRRS-KPGA
.|..| . |.| . .    .||.  |      .|||. ..| .       | |.|||  | |||   .| |||.   .   . |. |.   || . .  .
rlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars.....tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraas

ITTLEQYTSIYDVV
. ||.||  |. |.
vqtlqqymliwkvl
0049260 (Phosphotyrosine protein) phosphatases II 6167-6351 1.7e-23 78.4 In-house 2-144 (152) alignment 
Range on Protein: 6167-6351
Range on HMM: 2-144/152.0
LNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEED----CCYQYWidsmtydefvvkvssetnasgyierklkvsidkesrsvlQLQVTDW
.. |. ...|| .| |..||. |||.|. . ....|.||. ...    .|.||.                                       | . . |
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.......................................qylhlpw

PQDGVVREPSTILKIIDEVREKqKSGKKGPVVVHCSDTVSRSGVYCSVSIALeqcnaeGVVDVFQVTKALRRSKPGAITTLEQYTSIYD
| .||   .  .| ... ...  .  |.|||.||||  |.|.|...   . |        |..... . .|. .|||... .|.  .|.
pDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0051082 (Phosphotyrosine protein) phosphatases II 6159-6352 2.7e-23 77.6 In-house 3-148 (151) alignment 
Range on Protein: 6159-6352
Range on HMM: 3-148/151.0
DGYINASYLNSYrgknaFILAQSPMEntvrDFWKMIVDCKVSVIIMLCG--EEDCCYQYWIDSMtydefvvkvssetnasgyierklkvsidkesRSVLQ
..|||.||. ..     ... . |..    ||.... . ....|..|..  | . |..|. .                                 . ||.
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...............................ievlh

LQVTDWPQDGVVREPSTILKIIDEVREkqksGKKGPVVVHCSDTVSRSGVYCSVSIALEQcnaegvVDVFQVTKALRRSKPGAITTLEQYTSIYDV
....|||  |.   . ..|........     |.|||.||||  ..|.|. . . . |..      |..... . .|.. ||.... .|.  .. .
ipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 5880-6072 1e-22 75.0 In-house 83-280 (302) alignment 
Range on Protein: 5880-6072
Range on HMM: 83-280/302.0
VDGYSSSKKFIT-TQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQ-----D---
.||    .|       | |.||  .| || | .   .| |....|... || .|. .   .. .|| . |   . .|  . |  | |...      .   
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

ESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYRrvinNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYL
..   .|.   . ..||| | |. | . . . .         | ..|||||||||||| ..|.   ..  .|.|| |.. ||  .|| |   ||. .| .
kkkvkktvdilafsawpdhGapkeaytaldilk....fcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

FL
.|
yl
0048179 (Phosphotyrosine protein) phosphatases II 5963-6074 2e-22 74.9 In-house 48-139 (144) alignment 
Range on Protein: 5963-6074
Range on HMM: 48-139/144.0
KlsitiqdessdshtLIQYQLTSWPDQGVPDYATSFMSLYRRVINNWSlSKGTILVHCSAGVGRTGVFIAVDIALeqakKEKvVDIAGIVNRLRQQRMKM
                |||. ..||| ||||... . .... . .  . ..| .||||||||||||...| .. .    |.. ...  .....|..|. .
e..............giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpga

VQSLDQYLFLHD
|.. .|. ||..
vpnpgqlrfLle
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 6158-6359 4.5e-22 73.5 In-house 45-261 (290) alignment 
Range on Protein: 6158-6359
Range on HMM: 45-261/290.0
TDGYINASYLNSYRGkNAFILAQSPMEN-------TVRDFWKMIVDCKVSVIIMLCGEED--------CCYQYW---ID-SMTYDEFVVKVSSETNASGY
.|.|| |...    |  ..|| ||| |.       |. .|| |. . ||  ..|||  |.         | .|    .. ..... . ||  |  .  . 
nddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

IERKLKVSIDKESR-SVLQLQVTDWPQDGVVREPSTILKIIDEVReKqksgKKGPVVVHCSDTVSRSGVYCSVSIALEQCN-AEGVVDVFQVTKALRRSK
..|.| |  |.|    |   .. .| .  | ... |.|..|. |. .    .| ||.||| | .||| .  .. ..       .| | . .| ||||. .
etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.a....sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

PGAITTLEQYTSIYDVVDLYLQT
  |||. .... .  .. |... 
alaitsalelafvdagivllaie
subfamily_CG42327_pd Subfamily CG42327 5869-6007 5.2e-22 72.9 In-house 53-192 (319) alignment 
Range on Protein: 5869-6007
Range on HMM: 53-192/319.0
ECQTEYINANFVDGYSSSK-KFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTS--EVKEFGPFNVILQNTQTYPDLFIRKLS
. ..||..|..| || ...  .|..| ...|.  ||||..|. .   || ||.| | |  .| .|.| . .  . . .| . | |.. ..    .|  | 
ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistll

ITIQdESSDSHTLIQYQLtSWPDQGVPDYATSFMSLYRRVIN
.    . . |  |  |    |.. .||   ......  .| .
lkrv.dkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 6101-6359 8e-22 72.0 In-house 18-287 (302) alignment 
Range on Protein: 6101-6359
Range on HMM: 18-287/302.0
KNNRKTNSTKLEAQYNLLYQLTPDPNDvdCKSAKAHASKNRSNNYLPPDKFIVALK-ETDGYINASYLNSYRGKNAFILAQSPMENTV---RDFWKMIVD
| ... .......... . ..  | .   ||. |.. .||.|...  .|. .| |. | | |.||| ..    ..  |||| |  ...    .||.|. .
klvksldtaevkkefkkidtmkvdlek..CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfq

CKVSVIIMLCGEEDCCY---QYWI----DSMTYDEFVV---KVSSETNASgyIERKLKVSIDKESRSVLQL--QVTDWPQDGVVREPSTILKIIDEVREK
 |.  . .| |||.. .   ...     |  .|... |   ||..  ..    .  . |  .  | |||     .| |.|. |  . ... | . .| .|
ekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeek..tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfak

QKSGKKgPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQT
. .... ..|.     . | |.  .. .|.|. ...  . . .. |..|  .| |. .|.||.|.| .. ||...
kikade.ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 6136-6358 3.7e-21 70.4 In-house 43-272 (288) alignment 
Range on Protein: 6136-6358
Range on HMM: 43-272/288.0
HASKNRSNNYLPPDKFIVALK-ETDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGE----EDCCYQYWIDSMTYDEFVVKVS
 ....| .|    |   | |. ..| ||.|  . | . |. .| ||.|.. |.  .|||...  |  |.|||       .   .|.   .     . .. 
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlc

SETNA-SGYIERKLKVSIDKESRSVL------QLQVTDWPQDGVVREPSTILKIIDEVREKQKsgkkgPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVV
. .      |.. .|||. . |. .       .| . .|..|||  .  . |.... ... ||     |.|||.|  | |.|    . ||||.   .  .
tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk.....PivvhssaGvGrtgtlililialeslrlddfl

DVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQ
 . .. . || ..  ||.|  ||  .. .|  .| 
girsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 6131-6360 6.9e-21 69.2 In-house 50-292 (305) alignment 
Range on Protein: 6131-6360
Range on HMM: 50-292/305.0
KSAKAHASKNRSNNYLPPDKFIVALKETD--GYINASYLNSY-RGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEE----DCCYQYWIDSMTYD
.||.   .||| ..    |. .| |..     || | |.      .. || || |...|. .|| |... ||  |.|||         | |||  ..   
qsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

EFVVKVSSETNASG--YIERK-------LKVSI-DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVRekqksGKKGPVVVHCSDTVSRSGVYCSVSIA
  .       | ||   .||        |...   ... || .|| |.||. ||     | |...  .|     | | |.|||||  . |.|   ..   
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair.....gskvpivvhcsagigrtgtivaieyi

LEQCNA-EGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYLQTT
||.      .  . .. ||||  .  .| .  ||  |. |.  |.   
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 6109-6353 2.2e-20 67.7 In-house 7-291 (297) alignment 
Range on Protein: 6109-6353
Range on HMM: 7-291/297.0
TKLEAQYNLLYQLTpDPNDvdCKSAKAHAS--KNRSNNYLPPDKFIVALKET---DGYINASYLNSYR--GKNAFILAQSPMENTVRDFWKMIVDCKVSV
 .|||...||.. .  ...    |||  .|  ||| .. |  |.  | |. .     |||| |.       .  .|||| |...|| |||.....  | |
keleaekdllldea.rges..fssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrv

IIMLC----GEEDCCYQYWIDS----MTYDEFVVKVSSETNAS---GYIeRKLKVSIDKESRSVLQLQVTDWPQDGVV-------RE----------PST
|.|..    .  | |. || ..    ..  ..||.  |.|       ..  .|..   .||| |   |   ||. ||        |              
ivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpm

ILKIID--------EVRE-KQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVV
.| ...        ..   . .  .. ...||||  | ||||     . |..   . . ||  . . ||  ..  . ||||.. .||.|
mlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_ptpA1_pd Subfamily ptpA1 6110-6315 2.6e-19 64.2 In-house 22-254 (418) alignment 
Range on Protein: 6110-6315
Range on HMM: 22-254/418.0
KLEAQYNLLYQlTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALK-----ETDGYINASYLNSYRGKNaFILAQSPMENTVRDFWKMIVDCKVSVIIM
|.. .. || . .  |..      |  .||||  | || ..  | ||     |   |||| |..    |. || .| |. ||. |||.|. . .. .|.|
kikeefrllee.svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivm

LCGEE-DC---CYQYWIDSMTYDEFVVKVSSET---------------NASGYIERKLKVSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQ
|  |  .|   | .|| . .  ..| .    .                     | |....... |.| . | |   ||.  .      . ...  . ..|
lsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq

K-----SGKKGPVVVHCSDTVSRSGVYCSVSIALE
.     | .. |..||||  | |.| .|.  | ..
nqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_egg_pd Subfamily egg 6105-6357 5.6e-19 62.9 In-house 26-270 (307) alignment 
Range on Protein: 6105-6357
Range on HMM: 26-270/307.0
KTNSTKLEAQYNLLYQLTPDPNDVDCKSAKAHASKNRSNNYLPpdkfivalketdGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIM
 ..   |.  ..  ..     . |.||     . . |   ||              .| | ...     | |||||.|. ||| |||.|.   .|  |.|
svdeislttaasdnnlekarskrvhckdssrvklelrrGqyld............dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

LCGEE--DCCYQYWIDSMTYDEFV---------VKVSSETNASGYIErKLK-VSIDKESRSVLQLQvTDWPQDGVVREPSTILKIIdevREKQKsgkkgP
|      . |  ||  . .    .         .|| |...    .  ||| |  |.| | .   |  |. . . |  |  .|. .   |.  |     |
ltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvt.klklvGgddeerflehwq.gdvnnssdvysplrvlrkl...rnlsk.....p

VVVHCSDTVSRSGVYCSVSIALEQCNAEGV--VDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYL
|||.. . ||....  .. ||| .     .    | .  . ||. .. .. .  .|  .| .| ...
vvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
0044763 (Phosphotyrosine protein) phosphatases II 6155-6356 1.3e-18 62.8 In-house 9-170 (178) alignment 
Range on Protein: 6155-6356
Range on HMM: 9-170/178.0
LKETDG-----YINASYLNSYrgknaFILAQSPMentvRDFWKMIVDCKVSVIIMLCGEEDCC----YQYWIDSMTydefvvkvssetnasgyierklkv
| .  |     |||||.   .     ..|.. |.     |..... . ....|..|..|  .     ..|| ...                         
lsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag........................

sidkesrsvLQLQVTDWPQDGVVREPSTILKIIDEVREKQKsGKKGPVVVHCSDTVSRSGVYCSVSIALEQcnaeGVvDVFQVTKALRRSKPgAITTLEQ
         .| . . .| .||   .. .|.... ..| ..  |.|||.||||  |.|||. .   . ...    |. ..... . .|. .| .... .|
.........iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgq

YTSIYDVVDLY
.  .|..   .
lrqLyefelrl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 5899-6038 3.2e-18 60.7 In-house 40-173 (255) alignment 
Range on Protein: 5899-6038
Range on HMM: 40-173/255.0
TLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNtqTYPDLFIRKLSITIQD-ESSDSHTLIQYQLTSWPDQGVPDYATS
|.  |.. | | ..  .|||. ..| |. || .|.|    | . .   ||.  .  .  |  .| | || .  |    ||.  |. . |...  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

FMSLYRRVINnwslSKgTILVHCSAGVGRTGVFIAVDIALE
 . ... | .    || ...||||.|.||.  |. ....  
ilnilkvvrd....sk.svvvhCstGiGrsaafvlaelvyq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 5966-6077 4.2e-18 60.2 In-house 205-341 (350) alignment 
Range on Protein: 5966-6077
Range on HMM: 205-341/350.0
ITIQDESSDSHTLIQYQLTSWPDQGVPDYATSFMSLYR---RVIN-----NWSL--SKGTILVHCSAGVGRTGVFIAVDIALE----------QAKKEK-
. |.  .|| . . | |.  |.| ..     |...       .|.     ...      .|||||||||||||.....|  |.          . .| . 
taitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldv

---VVD-IAGIVNRLRQQRMKMVQSLDQYLFLHDALL
   . | |  |||.||.||..|||.|||..|...|||
aaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 6137-6357 5.6e-18 59.7 In-house 49-287 (305) alignment 
Range on Protein: 6137-6357
Range on HMM: 49-287/305.0
ASKNRSNNYLPPDKFIVALKET--DGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEE----DCCYQYWI----DSMTYDEFV
| |||  .    |.  | |. .    || | |. .    . || .|.|.|.|  ||| | .. ||  |.|||         |..|.     | ....|  
agknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekg

VKVSSETNASGYIERK----LKV-----SI---DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREkqksgKKGPVVVHCSDTVSRSGVYCSVSIAL
 |.|   ..|. .. .     ||      |    ...| | .    |||. ||     .||... . |       |||.|||||  . |.|    .   |
qkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp.....skgpivvhcsagigrtgsvvmleyil

EQCNAEGVV-DVFQVTKALRRSKPGAITTLEQYTSIYDVVDLYL
.|  |  .. |  .. . .|  .  .| | .||  ...|.  |.
dqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 6161-6345 1.7e-17 58.2 In-house 77-269 (301) alignment 
Range on Protein: 6161-6345
Range on HMM: 77-269/301.0
YINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGE----EDCCYQYWI----DSMTYDEFVVKVSSETN--ASGYIERKLKVS---I
 | | ....    . || .|.|..||  ||| |.|  .|  |.||. .    |. | .|      ...  . | .|. ..        ..|.|.|     
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

DKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKsgkkgPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQ
. ..|.|.  | ..|.. || .    . .... |.. .|     |.|||||. . ||  . .  .   . .|.  ... .  | ||  .  .. | .|
kfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 5840-5937 3.2e-17 57.3 In-house 44-154 (350) alignment 
Range on Protein: 5840-5937
Range on HMM: 44-154/350.0
SNENKALNRLKNITVYDDNRIILT-------PLSHLECQTEYINANFVDGY------SSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGK
  |  | || |||  |. .|..|           |     .|||||..          .. |.| ||.|.. |. ||...| .     |..||.. | . 
GvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnl

SKCRQYWPNST
 || .||.. .
ekcyrYWqegs
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 6015-6080 1.5e-16 55.1 In-house 230-295 (297) alignment 
Range on Protein: 6015-6080
Range on HMM: 230-295/297.0
TILVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEI
 .||||||||||.|| .  |. |.. .|... |.| |.. ||.|| ..||.|.|. .|.|| |. .
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 6018-6084 1.8e-16 54.2 In-house 2-68 (69) alignment 
Range on Protein: 6018-6084
Range on HMM: 2-68/69.0
VHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGK
||||.| |||| |||. . . . | ||.|||   |. .|. |  ||   ..|.|.|||| | .  ||
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklGk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 6017-6084 1.9e-16 54.2 In-house 2-69 (69) alignment 
Range on Protein: 6017-6084
Range on HMM: 2-69/69.0
LVHCSAGVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEIICGK
.||||.| |||| |||. . . . | ||.|||   |. .|. |  ||    .|.|.|||| | .  ||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklGk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 6171-6352 7.8e-16 52.8 In-house 2-199 (199) alignment 
Range on Protein: 6171-6352
Range on HMM: 2-199/199.0
RGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEEDCC---Y-QYWID--S--MTYDEFVVKVSSETNASGYIERKLKV----SIDKESRSVLQLQ
.|.  .| .| |. .|. |||.|. .     |.|.  ..      |  ||    |    |  . | . . |  . |    | .    .    .| . . |
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

VTDWPQDGVVRE--PSTILKIIDEVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQC--NAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDV
 | | .           ..    ||  | .  |  ||.|||||    .||. .. | .         |||.|.|.| ||... | |..|..|  ||.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 6172-6352 1.1e-15 52.3 In-house 2-198 (198) alignment 
Range on Protein: 6172-6352
Range on HMM: 2-198/198.0
GKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEEDCC---Y-QYWID--S--MTYDEFVVKVSSETNASGYIERKLKV----SIDKESRSVLQLQV
|.  .| .| |. .|. |||.|. .     |.|.  ..      |  ||    |    |  . | . . |  . |    | .    .    .| . . | 
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPQDGVVRE--PSTILKIIDEVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQC--NAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDV
| | .           ..    ||  | .  |  ||.|||||    .||. .. | .         |||.|.|.| ||... | |..|..|  ||.|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_eak_pd Subfamily eak 5837-6081 2e-15 51.0 In-house 46-306 (332) alignment 
Range on Protein: 5837-6081
Range on HMM: 46-306/332.0
VGKSNENKALNrLKNITVYDDNRIILTPlsHLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNS
...  |.   | . .|  || . . ||.      .  ||||  ..     .|.| |  . .| .  ||... ...  .||.| .  | .  |  .|.|. 
etarleavnrn.vvkivpydrylvrlts..sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

TSEVKEFGPFNVILQNTQTYPDLFIRKLSITIQDEssdSHTLIQYQLTSWPDQGVPDYAtSFMSLYRRVI--------NNW--SLS-----------KGT
| |. .|| ..|  ..      |  |.| ..  .|   .| .  |..  | .  .| |   |..|.. .         .     ||             .
treelkfGildverkefvkrniletrllelskGne...thrvlhykvfGwtettlpkye.dflalrkvmkevGvlllivmksallsstlkkyihtppsfa

ILVHCSAGVGRTGVFIAVDIA--LEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEII
 .. .. |  |.|||. .|.   | ..||. .  .  .. . ...|.. |    |. |.....|. . 
piiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_hpo-7_pd Subfamily hpo-7 5898-6038 3.5e-15 50.6 In-house 45-179 (263) alignment 
Range on Protein: 5898-6038
Range on HMM: 45-179/263.0
DTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSEVKEFGPFNVILQNTQTypDLFIRKLSITI-QDESSDSHTLIQYQLTSWPDQGVPDYAT
.|.  |.. | | ..  .|||.  .| |. || .|.|    | . .   ||   ..|   |. .. | ..   .|    ||. .|. . |...  |  | 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

SFMSLYRRVINnwslSKgTILVHCSAGVGRTGVFIAVDIALE
. . . . . |    ||  . ||||.|.||.  |  ....  
eilnilkvarn....sk.slvvhcstGiGrsaafsvaElvyq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 6139-6352 3.8e-15 50.3 In-house 55-285 (310) alignment 
Range on Protein: 6139-6352
Range on HMM: 55-285/310.0
KNRSNNYLPPDKFIVALK----ETDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCG--EED--CCYQYWIDS-MTYDEFVVKV
|||  . .  |.  | ||      . || | |...   ...|| .| |.. |. |||.|| . .   |..||   ||    |  ||    .|    ...|
knrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirv

SSETNASGYIER-KL-------KVSIDKESRSVLQLQV-----TDWPQDGVVREPStilKIIDEVRekQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQ
.  ...|  .|  .|       .| .|..   . .|.|      .||. ||  |     . . .        ..||.|||||  . | .| ... .....
tnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc...htvpqrl..laqvrhgpcvvhcsagkdrlyvvvalklkidk

CNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDV
 .    ||. .|   |..|.   | |  ||. |  |
ldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_CG42327_pd Subfamily CG42327 6012-6075 6.5e-15 49.6 In-house 246-310 (319) alignment 
Range on Protein: 6012-6075
Range on HMM: 246-310/319.0
SKGTILVHCSAGVGRTGVFIAVDIALEQAKKE-KVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDA
|.| . |||| ||||||. || |||... ..  . |||  .|  .|..| . |.. .|| |..  
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
0048076 (Phosphotyrosine protein) phosphatases II 6245-6355 2.1e-14 48.9 In-house 38-141 (145) alignment 
Range on Protein: 6245-6355
Range on HMM: 38-141/145.0
VSIDKESRSVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGkkGPVVVHCSDTVSRSGVYCSVSIALEqcnaEGvVDVFQVTKALRRSKPGAITTLE
  .. ..| ..|.. ..||  ||   ....|.... ..| .|.|  |||.||||  |.|.|...   . |.    .| |..... . .|.  |||... .
selellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpg

QYTSIYDVVDL
|.  .|...  
qlrflyefele
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 6108-6240 7.7e-14 46.2 In-house 19-173 (350) alignment 
Range on Protein: 6108-6240
Range on HMM: 19-173/350.0
STKLEAQYNLLYQLTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALK-------------ETDGYINASYLNSY----RGKNAF--ILAQSPMENTVR
 .. .... |  . . . |||   .     .||| .| || ..  | ||             .|. ||||.||.      . .  |  | .|.|. .|| 
nstvksrlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvd

DFWKMIVDCKVSVIIMLCGEED----CCYQYWiDSMTYDEFVVKVSSETNASGYIE
||.|.|.  || ||..|  . .     ||.|| .  .||.. ||..|  .  . |.
dfykvillnkvkvilsltsdvelnlekcyrYW.qegsydditvklaskwenimgin
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 5965-6078 8.7e-14 45.6 In-house 209-342 (349) alignment 
Range on Protein: 5965-6078
Range on HMM: 209-342/349.0
SITIqdESSDSHTLIQYQLTSWPDQGVPDYATSFMS---LYRRVINNWS-------LSKGTILVHCSAGVGRTGVFIAVDIALE---QAKK--EKV----
.|..  .... . |.| |.  |.| ..     |..        .|..             |.||||||| |||||.. .|. |.     ..   |.    
aill..avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqa

--V-DIAGIVNRLRQQRMKMVQSLDQYLFLHDALLE
     |  ||| ||.||. ||| | |. ....|||.
llkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 6104-6268 1.8e-13 44.7 In-house 62-236 (244) alignment 
Range on Protein: 6104-6268
Range on HMM: 62-236/244.0
RKTNSTKLEAQYNLLYQ--LTPDPNDVDCKSAKAHASKNRSNNYLPPDKFIVALKE---TDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCK
.|  |  ..|.|    |  . |||. .        . |||    || |   | | .    . |||||..        .||.| |. .|  |||||... .
kkegsdyinanyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerh

VSVIIMLCGEEDcCYQYWIDSMT---YDEFV-VKVSSETNASGYIERKLKVSID-KESRSVL-QLQVTDWPQDGVV
| |...|   |.   .|| ||     |.| . | ..   .       .|..  | .||   |  .|...|| ||  
vnvlvvlgsvee.edeywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgtt
fn3 Fibronectin type III domain 4646-4732 3.2e-13 42.8 Pfam-A 1-82 (85) alignment 
Range on Protein: 4646-4732
Range on HMM: 1-82/85.0
SPVTSLSVSSVSTTDITLSWTIP-SSGNYVTYYTVYYIPSCLELssGNKTVSVTPHqstTTfSYTLTGLHSGVNYTFTVRAGNVLGGS
|... ||||.|..| .||||. | . |  .|.|.| | ..  .     |...|...   || |.|||||  | .|.|.|.| |  |..
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprt...tt.svtltgLkpgteYefrVqavngageg
0048179 (Phosphotyrosine protein) phosphatases II 6195-6351 3.2e-13 45.1 In-house 26-139 (144) alignment 
Range on Protein: 6195-6351
Range on HMM: 26-139/144.0
VDCKVSVIIMLCGEedCCYQYWIDSmtydefvvkvssetnasgyierklkvsidkesrsVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKSGkkGPVV
 . ... .| |. |  . ......                                   ..|.. ..||  ||   .. .|.... ..| ...|  |||.
kklgittvinltee..yepeflere..................................giqylhlpwpDhgvpdllellleflefieealeeg..gpvl

VHCSDTVSRSGVYCSVSIALeqcnAEGvVDVFQVTKALRRSKPGAITTLEQYTSIYD
||||  |.|.|...   . .     .| ...... . .|.  |||... .|.  ...
VHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 6138-6354 4.3e-13 43.6 In-house 45-273 (312) alignment 
Range on Protein: 6138-6354
Range on HMM: 45-273/312.0
SKNRSNNYLPPDK--FIVALKEtDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGE----EDCCYQYWIDSMT---------Y
  ||  |    |.  | .|  | . || | ...     . |. .|.|.|||.  ||.. .    . ||.|||      . | .|  | ..         |
dlnrypniqcwdrgrftlagde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvy

DEFVVKVSSETNASGYI-ERKLKVSIDK---ESRsVLQLQVTDWPQDGVVREPSTILKIIDEVREKQKsgkkgPVVVHCSDTVSRSGVYC---SVSIALE
 |.. ..    ..   |  | ||| .     ||. . . | . ||. |.     | |...  |.  .|     ||. |||  | |.|  .   |.  || 
teycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalr

QCNAEGVVDVFQVtkaLRRSKPGAITTLEQYTSIYDVVD
.   . | |.| .   ||. .  .. .. ||     .| 
hprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 6149-6356 5.4e-13 43.5 In-house 48-269 (285) alignment 
Range on Protein: 6149-6356
Range on HMM: 48-269/285.0
DKFIVALKETD-GYINASYLNS-YRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLC-----GEEDCCYQYWI---DSMTYD--EFVVKVSSETNAS
..  | ||. |  || ||..    . ....| .| |. .|. |||.|| . |.. ..|||     | | |.  |     . . .   |  .    |   .
eetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaia

GYIERKLKVSIDKESRS----VLQLQVTDWPQDGVVREPSTILKIIDEVreKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKAL
| |   | |   ... |    . ..||  ||..    .   ....   |  |.   |. |..||||  | |.  .  .  |  .   .  ...... . .
gtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwv..kkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivrem

RRSKPGAITTLEQYTSIYDVVDLY
|  .  |. .  |.  .| |.  |
ramrfqavqshmqflflyvvlmey
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 5880-5970 1.9e-12 41.2 In-house 229-315 (440) alignment 
Range on Protein: 5880-5970
Range on HMM: 229-315/440.0
VDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEggkSKCRQYWPNSTSEVKeFGPFNVILQNTQTYPDLFIRKLSITIQD
..|||  . ||.|| |.  |..|||||. . |  .|.|| .|..     |  |||  |  |  |||| |  . ..    . .| | .  ..
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvt.fgpftvghkgsenmnrvkvrtlelkyke
fn3 Fibronectin type III domain 1987-2063 6.9e-12 38.5 Pfam-A 8-83 (85) alignment 
Range on Protein: 1987-2063
Range on HMM: 8-83/85.0
VAVLNETTINITWSPPSHPNGEITGFIVRIATDAITSpNNVPFVTGRASYSLIFGGLKTRIPYYVSVVAVNQVGEGN
|   ..|.....||||....|.|||. |. ...  ..   . | . | ..|... |||   .| ..| |||..||| 
vsevtstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 5455-5541 7e-12 38.5 Pfam-A 1-82 (85) alignment 
Range on Protein: 5455-5541
Range on HMM: 1-82/85.0
SPVTSLSVSSVSTTDITLSWTIP-SSGNYVTYYTVYYIPSCPELslgngT-ISVIpHQSTTTySYTLTGLHSGVNYTITVIAGNVLGGS
|... ||||.|..| .||||. | . |  .|.|.| | ..  .         ..    .||| |.|||||  | .|...| | |  |..
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.....ewkeft.vprttt.svtltgLkpgteYefrVqavngageg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 6158-6268 7.2e-12 39.7 In-house 12-127 (130) alignment 
Range on Protein: 6158-6268
Range on HMM: 12-127/130.0
TDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEEDcCYQYWIDSMTYD---EFVVKVSSETNASGYIER-KLKVSIDKE--S
 . |||||..      . ..|.| |. .|  |||||...  | |...|   |.   .|| ||  ..   | ..  ... . . .|.  .|... |     
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.edeywpdsePlewyeediivtltdrdefknikasnleiesdlnesh

RSVLQLQVTDWPQDGVV
...  .|...|| ||  
qaltmfqisnwpsdgtt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 5844-5991 9.1e-12 39.1 In-house 97-235 (244) alignment 
Range on Protein: 5844-5991
Range on HMM: 97-235/244.0
KALNRLKNITVYDDNRIiltPLSHLECQTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWqERPVSI-VMLTKLKEggkskCRQYWPNSTSEVKE
   ||      .| ||.   |||.      |||| ||     . ..| || |. || .|||...  || | . |.|  ..|       .|||.|      
swknregaglpfdfnrv...plskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvlgsvee.....edeywpdseplewy

FGPFNVILQNTQTYPDlfIRKLSITIQDESSDSH-TLIQYQLTSWPDQGV
     | | . . . .  |.   . |. .  .|| .|  .|.. || .| 
eeditvtltdrdefkn..ikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 6180-6348 2.8e-11 37.4 In-house 97-279 (302) alignment 
Range on Protein: 6180-6348
Range on HMM: 97-279/302.0
QSPMENTVRDFWKMIVDCKVSVIIMLCG----EEDCCYQYWID----SMTYDEFVVKV-SSETNASGYIERKL----------KVSIDKESRSVLQLQVT
  |  .|.  .| .| . .|.... ||.    ||  | .|. |     ... .. ||  | .|. . . ..|           .   .|  ..|  |. .
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

DWPQDGVVREPSTILKIIDEVrEkqksGKKGPVVVHCSDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTS
 ||. |  .|. | |.|.    |      |  |.||||  | |.|   ..   .. |  . | |. .. . .|. . ||. . .| . 
awpdhGapkeaytaldilkfc.e....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
fn3 Fibronectin type III domain 3588-3661 3.1e-11 36.4 Pfam-A 10-82 (85) alignment 
Range on Protein: 3588-3661
Range on HMM: 10-82/85.0
VLNETTINITWSPPSHPNGEITGFIIRIATDAITSeRYSSFMIDKALYALIYGGLKPGVPYYVSVVAANQVGER
  ..|.....||||....|.|||. .. ...  ..    .| ...  . ..  ||||| .| ..| | |..|| 
evtstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngageg
subfamily_CG42327_pd Subfamily CG42327 6289-6356 3.3e-11 37.4 In-house 246-314 (319) alignment 
Range on Protein: 6289-6356
Range on HMM: 246-314/319.0
KKGPVVVHCSDTVSRSGVYCSVSIALEQCNAE-GVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLY
..||.|||||| | |.|.  .  ||... .     ||. |.   .|| .  |. | |||  || |.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 5871-5956 1.1e-10 35.3 In-house 89-171 (349) alignment 
Range on Protein: 5871-5956
Range on HMM: 89-171/349.0
QTEYINANFVD--GYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTsevkeFGPFNVILQNTQTY
  .|||||..    .|  ||.|.|| |.  |. ||...|  ..   .. |.. || .  || .|| . .     .  ..| |||.  |
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels.....ysnitvklqnssly
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 5842-6081 1.2e-10 35.5 In-house 46-280 (303) alignment 
Range on Protein: 5842-6081
Range on HMM: 46-280/303.0
ENKALNRLKNITVYDDNRIILTplshlecQTEYINANFVDgYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVMLTKLKEGGKSKCRQYWPNSTSeVK
.|   ||. .. . |  .. |.       .. || |....   |||| | || |.  |  |||..| ...   ...|    |  |      .|.      
knmdknrfvdvicldhskvkls.......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.fl

EFGPFNVIL---QNTQTYPDLFIRKLSITIQDESSDSHtlIqYQLTSWPDQGVPDY-ATSFMS---LYRRVINNWSLSKGTILVHCSaGVGRTGVFIAVD
.|    . .   .. .      .. ||..  |  |  |  . ..  .|| . .|   .  |.      . |. ..| |. |. .  | |.||.| |   .
kfeersirvgefkrvelgdgwvlkvlsvsngdyksflh..v.hhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls.gcgragtfalfe

IALEQAKKE-KVVDIAGIVNRLRQQRMKMVQSLDQYLFLHDALLEEII
 |    ..|   .|.   .. .|. |.. || | |. ...  | | ..
tahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_CG42327_pd Subfamily CG42327 6156-6287 1.9e-10 34.9 In-house 53-196 (319) alignment 
Range on Protein: 6156-6287
Range on HMM: 53-196/319.0
KETDGYINASYLNSYRG-KNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGE-ED---CCYQYWIDSMT------YDEFVVKVSSETNASGYIERKLK
.. | |..|||.  |.  .| .| || ..|..  |||... . .  ||. |.   |     | .|.  . |      | .. | .        |.   | 
ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistll

V-SIDK-ESRSVLQLQVtDWPQDGVVREPSTILKIIDEVREKQKS
.  .|| ||| .      .|.. .|  |..... .. |||.  ||
lkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslks
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 5871-5991 2.5e-10 34.8 In-house 12-126 (130) alignment 
Range on Protein: 5871-5991
Range on HMM: 12-126/130.0
QTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWqERPVSIV-MLTKLKEggkskCRQYWPNStsEVKEFGPFNVILQNTQTYPDLFIRKLSITIQ
. .||||.||     ..... || |. || .|||...  || | .. .|  ..|       .|||.|  |  |.   ..|.  |.     .|.   . |.
gntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvlgsvee.....edeywpds..ePlewyeediivtltdrdefknikasnleie

DESSDSH-TLIQYQLTSWPDQGV
..  .|| .|  .|.. || .| 
sdlneshqaltmfqisnwpsdgt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 6157-6236 8.8e-10 32.4 In-house 88-172 (349) alignment 
Range on Protein: 6157-6236
Range on HMM: 88-172/349.0
ETDGYINASYLNS--YRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEED----CCYQYWiDSMTYDEFVVKVSSETNAS
  | |||| ||.   .  .. .|  | |.  || ||.|.|.  .| ... |  ...     |..|| . ..|... ||.    . .
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw.qelsysnitvklqnsslyi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 6155-6205 1.1e-09 32.3 In-house 66-116 (347) alignment 
Range on Protein: 6155-6205
Range on HMM: 66-116/347.0
LKETDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIML
  ....|||||...    .. .||.| |. .||||||||.   ||. .. .
addvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 5839-5917 2.1e-09 31.3 In-house 33-115 (347) alignment 
Range on Protein: 5839-5917
Range on HMM: 33-115/347.0
KSNENKALNRLKNITVYDDNRIILTPLSHLEC----QTEYINANFVDGYSSSKKFITTQGPMKDTLVDFWRLIWQERPVSIVM
. . . . || |.  . |. |..|.|     .       ||||  .    .||..| || |. ||. |||...   .   .| 
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
fn3 Fibronectin type III domain 1781-1855 2.3e-09 30.4 Pfam-A 13-84 (85) alignment 
Range on Protein: 1781-1855
Range on HMM: 13-84/85.0
PRNVTLTWTAPAliDQNGAPVGYNLTCINTNGVSvNGLSPTQSSTNTMFTITDVMPFTGYTCSLSFINVVGEGPP
....||.|..|.  |..|  .||.... ...| .    . | ..| | .|.|.  | | |....  .| .||||.
stsltlsWsppk..dgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 4388-4459 2.6e-09 30.3 Pfam-A 1-79 (85) alignment 
Range on Protein: 4388-4459
Range on HMM: 1-79/85.0
SAPSSVTVATKTSDTITLYWIFD---QSDADGYVVYVNNDTDT--VQIVQVKGSS--ITLNGLRGGTTYSITVRAYQQL
|||. ..|   ||...|| |      ... .|| | . .....   . ..|....   ||.||. ||.|...|.|. . 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 6137-6353 5.8e-09 30.0 In-house 48-275 (303) alignment 
Range on Protein: 6137-6353
Range on HMM: 48-275/303.0
ASKNRSNNYLPPDKFIVALKETdGYINASYLNSYRGKNAfILAQSPMENTVRDFWKMIVDCKVSVIIMLCGE-------EDCCYQYWIDSMTYDEFVVKV
  |||  . .  |.  | | ..  || ||||.    |.| ||.| |.  |  |||.||.. || ....|  .        |  .    | . ..| ...|
mdknrfvdvicldhskvklsds.syihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirv

SSETN---ASGYIERKLKVSIDkESRSVLQL-QVTDWPQDGVVRE-PSTILKIIDEVRE-KQKSGKKGPVVVHCSDTVSRSGVYCSVSIA-LEQCNAEGV
    .   . |.  . | ||   . .| |.. .  .||.. .  .  . ..| | ...   .|  .  | |      . |.| ..    | |   . .  
gefkrvelgdgwvlkvlsvsng.dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqas

VDVFQVTKALRRSKPGAITTLEQYTSIYDVV
.|. .. . .|  .  |.  | |.. .| ..
ldlvkclenvrngrlhavqnlsqfsvvytll
fn3 Fibronectin type III domain 4843-4931 6.9e-09 28.9 Pfam-A 9-85 (85) alignment 
Range on Protein: 4843-4931
Range on HMM: 9-85/85.0
SSImGSTWSVISWSVPSfiPQDYPIITYEIAYLSDNCSTlndddinnqALNQYNVSSGSTLAKITGLKHTSCYIFGVRAYNDNGYGKWT
|.. .||  ..||| |.  ... ||  ||. | ... .          . ....|.. .| ...||||  . | | |.|.|..|.|...
sev.tstsltlsWsppk..dgggpitgYeveyrekggge.........ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 5194-5265 9.8e-09 28.4 Pfam-A 1-79 (85) alignment 
Range on Protein: 5194-5265
Range on HMM: 1-79/85.0
SAPSFVTVATKTSNTIILYWIFD---QSDADGYVVYVNNDTDT--VQIVQVKGSS--ITLNGLRGGTTYSITVRAYQQL
|||. ..|   ||... | |      ... .|| | . .....   . ..|....   ||.||. ||.|...|.|. . 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 5819-5894 1.3e-08 28.9 In-house 23-95 (95) alignment 
Range on Protein: 5819-5894
Range on HMM: 23-95/95.0
NAFEEQFKNLY-DEEKPCDVGKSNENKALNRLKNITVYDDNRIILTPlshlECQTEYINANFVDGYSSSKKFITTQG
. |...|| .      |  || |. |   ||. ||  ||  |..||       ...|||| |||||.  . .|..||
qefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt....krdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 6173-6356 1.5e-08 29.1 In-house 34-221 (255) alignment 
Range on Protein: 6173-6356
Range on HMM: 34-221/255.0
KNAFILaqspmenTVRDFWKMIVDCKVSVIIMLCGEED----CCYQYWIDSMT-YDEF-VVKVSSETNASGYIERKLKV--SI--DKESRSVLQLQVTDW
|| ..|       ||  |...||  | .|..|||  ..     | .|.         .  |.|..  ...  . | |..   .   |. . |   . . |
knlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGW

PQDGVVREPSTILKIIDEVREKqKsgkkgPVVVHCSDTVSRSGVYCSVSIALE------QCNAEGVVDVFQVTKALRRSKPGAITTLEQY-TSIYDVVDL
..    ...  ||.|.  ||.  |     .||||||  . ||  .  . ..        .    . .|  .. . || ....|| |  |   ||. |.||
ieknaPelareilnilkvvrds.k.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

Y
.
v
PTEN_1 5975-6070 1.8e-08 29.4 In-house 91-185 (196) alignment 
Range on Protein: 5975-6070
Range on HMM: 91-185/196.0
SHTLIQYQLTSWPDQGVPDYATSFMSLYrrVINNWSL--S-KGTILVHCSAGVGRTGVFIAVdiALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQYL
 .  ..|   ...| |.|. .  |  ..  .. .| |  . ....|||| ||.||.|. .|    | ...|  . .   .|.. | ....   |. ..|
fksgveylhfpieDhgapslselfdick..sfiewllsdpngnvVlVHCkaGlgRsGtvvaa..yLmykgkltadeAlelvrekRppgapnspsqerll
subfamily_PTPDC1_pd Subfamily PTPDC1 5979-6074 2.1e-08 28.8 In-house 83-170 (182) alignment 
Range on Protein: 5979-6074
Range on HMM: 83-170/182.0
IQYQLTSWPDQGVPDYATsFMSLYrRvINNWSLSKGTILVHCSAGVGRTGVFIAVDIALEQAkkekvVDIAGIVNRLRQQRMKMVQSLDQYLFLHD
| .   .|.| ||.   .  . .  . . . .|..| . ||| || ||||| ||. .   .      .. .  .. .|..| | .|. .|  ....
iyvynfgwkDygvasler.iLdiv.k.vvafalqegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 5839-5926 2.3e-08 27.9 In-house 30-115 (332) alignment 
Range on Protein: 5839-5926
Range on HMM: 30-115/332.0
KSNENKALNRLKNITVYDDNRIILTPLshlECQTEYINANFVDGYSSSKKFITTQGPMKD-TLVDFWRLIWQERPVSIVMLTKLKEGGK
|  .|  .||.  . ..| .|. |.|    . . .. ||..|||||    .| .| |..| |   |||.. . .|  |...  . |  |
kflnnmdmnriphlycfdhsrvelapq...dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
fn3 Fibronectin type III domain 5653-5741 3e-08 26.9 Pfam-A 9-85 (85) alignment 
Range on Protein: 5653-5741
Range on HMM: 9-85/85.0
SSImGSTWSVISWSVPSfiPQDYPIITYEIGYLSDNCSTlndddiynqSLNQYNVSSSSTLANITGLKHTSCYIFGVRAYTTNGCGKWT
|.. .||  ..||| |.  ... ||  ||. | ... .            ....|....| ...||||  . | | |.|....|.|...
sev.tstsltlsWsppk..dgggpitgYeveyrekggge.........ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_hpo-7_pd Subfamily hpo-7 6173-6358 3e-08 27.9 In-house 37-229 (263) alignment 
Range on Protein: 6173-6358
Range on HMM: 37-229/263.0
KNAFILaqspMENTVRDFWKMIVDCKVSVIIMLCG--EE--DCCYQYWIDSMT-YDEF-VVKVSSETNASGYIERKLKVSI----DKESRSVLQLQVTDW
|| ..|    . .|.  |...||  | .|..|||   ||  . | .|.         .  |.|..    |  . . |..       |. . | . . . |
knlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgW

PQDGVVREPSTILKIIDEVREKqKSgkkgpVVVHCSDTVSRSGVYCSVSIALE------QCNAEGVVDVFQVTKALRRSKPGAITTLEQY-TSIYDVVDL
..   ....  ||.|.. .|.  ||     .|||||  . ||  .  . ..        .    . .|  .. . || |...|| |  |   ||. |.|.
iekndpelareilnilkvarns.ks.....lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf

YLQ
 |.
vln
fn3 Fibronectin type III domain 5368-5439 3.4e-08 26.7 Pfam-A 1-79 (85) alignment 
Range on Protein: 5368-5439
Range on HMM: 1-79/85.0
SPPSNVRGFILNATSIKLKWTNS----SMNDQYVIEYNYTGGVR-SKVASTREHE--IMLTDLSPRSTYTIRVYSYENI
|.|.|..    ..||. |.|. .    .  . | .||  .|| . .|  .. ...   .||.| | ..|..||... . 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 1870-1953 4.4e-08 26.4 Pfam-A 2-83 (85) alignment 
Range on Protein: 1870-1953
Range on HMM: 2-83/85.0
SPQNFTSIP-DKTAITFTWTRPATPNGIIIKYTLAVINLNTMTihnYTIIVSVNQTTVTKLVVGFSPYQNYTASVSASTIIGAGP
.|.|.. ..   | .|..|. |....| | .|.. . . ...    ..  ..|  || .  . |  |...|. .| | .  | ||
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
Ig_2 Immunoglobulin domain 1572-1643 4.8e-08 24.9 Pfam-A 14-69 (80) alignment 
Range on Protein: 1572-1643
Range on HMM: 14-69/80.0
YDNFTLTCTATkptiVIPNLVIAWTHNGtietgTVTTTGGNMtttvtntLSFDSSTASDSGTYRCTASITVP
 .|.||||.|.      |. .. |...|     . .... |        |   . .|.|||||.|.|| .  
genvtLtCqap....gnptpkvqwykdg.....eelsqsqna.......lfipnvsaedsGtYtCrasnseg
fn3 Fibronectin type III domain 4762-4826 7.6e-08 25.6 Pfam-A 18-85 (85) alignment 
Range on Protein: 4762-4826
Range on HMM: 18-85/85.0
LTWNDPNcsKHNGQIMSYTVLISNS-----SIAYNLTSTNRHAILNDLVFGTEYNISVAAVNFVGRGPFS
|.|. |.  . .|.| .|.|  ...     .  .....| ....|..|  ||||...|.||| .| ||.|
lsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 3469-3552 1.6e-07 24.6 Pfam-A 2-83 (85) alignment 
Range on Protein: 3469-3552
Range on HMM: 2-83/85.0
TPQNFTSIP-NKTAVTFTWTKPATPNGIIINYSLNVINQDVLTmhnYTILVSVNQTTVTQLVDGFSPYQNYTASVSASTIIGAGP
 |.|.. .. . | .|..|..|....| | .|.. . ...      ..  ..|  || .  . |  |...|. .| | .  | ||
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 4560-4628 3.1e-07 23.6 Pfam-A 2-77 (85) alignment 
Range on Protein: 4560-4628
Range on HMM: 2-77/85.0
TPSNVRGFILNATSIKVNWTNS----SINDQYVIEYNYTGGVR-SNVVSTREYE--ITLTDLSPKSTYTIRVYSYV
 |.|..    ..||. ..|. .    .  . | .||  .|| . .. ... . .   |||.| | ..|..||... 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavn
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 6173-6356 3.9e-07 23.0 In-house 114-308 (346) alignment 
Range on Protein: 6173-6356
Range on HMM: 114-308/346.0
KNAFILAQSP-M--ENTVRDFWKMIVDCKVSVIIMLCGEED---CCYQYWIDSMTYDEFVVKV---SSETNASGY-IERKLKVSIDKESRSVLQLQVTDW
.. .|.|| | |  |  | ||| || . .. .. ..  ..         . |     ..  |.      .. ||   |  ..|  . .| ||.       
ehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhha

PQDGVVREPST--ILKIIDEVREKQKSGKKGPVVVHCsDTVSRSGVYCSVSIALEQCNAEGVVDVFQVTKALRRSKPGAITTLEQYTSIYDVVDLY
|   . . | |  |.|.| .   ...  . |  ||       |.  .     |..| |     ..... |.... .||.. .. ||.||| .|  |
pwkhlqqppktlpiikmihqflsekqvqnagvcvvsl.fgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdy
I-set Immunoglobulin I-set domain 1085-1168 4.8e-07 21.5 Pfam-A 8-78 (90) alignment 
Range on Protein: 1085-1168
Range on HMM: 8-78/90.0
SVGSVEVGQSLTITCTITTVERLVVTpmitFIKMnDTDMEMlsnlNRPYSITTDDtgsvTNYTLILDPVRFEDAGMYTCIAEFN
.   |..|.|....||.. .. . |.      |  .....     .. ...| ..     .|||... |. .|.| ||| |. .
kdvevseGesvelectveGepepsvs....Wakd.gselks....sqrvkvtvee....aeytLtIsnvevsDeGkYtckatns
0038934 (Phosphotyrosine protein) phosphatases II 5979-6033 5.1e-07 25.0 In-house 80-135 (194) alignment 
Range on Protein: 5979-6033
Range on HMM: 80-135/194.0
IQYQLTSWPDQGVP---DYATSFMSLYRRVINNwsLSKGTILVHCSAGVGRTGVFIAV
|.|    .||.|..   .  ..|..|  ...|.   ..|...||| ||.||||...| 
ieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaa
Ig_3 Immunoglobulin domain 2660-2747 6e-07 21.6 Pfam-A 2-74 (75) alignment 
Range on Protein: 2660-2747
Range on HMM: 2-74/75.0
PVVTSSLNTTGRIFESndIQLLCTVTITPLdvnhTVNINWFgpnglitmnNTQYSISGGMINPTTNGSSLTFT-ASLSDNGTdYYCTAS
||...| ..|    ..  ..| |... .|     ...| |          . . ....|  .. ...|.||.. .. .|.|| | |.||
Pvisvspsptvtsggn..vtLtCsaeggpp....pptisWy.........ietppelqgsegssssestLtissvtsedsGt.YtCvas
Ig_3 Immunoglobulin domain 1427-1520 8.9e-07 21.1 Pfam-A 2-74 (75) alignment 
Range on Protein: 1427-1520
Range on HMM: 2-74/75.0
PSVDVSRSRENYFLAGsnLILTCDISVDPNvdtpfTVNVTWTmtgpnsmrlvdtdRINISSVMVRSGFNEYRSTLNFTTLSsIEDSGTYTCIVT
|.. ||.|  .    .  . ||| .   |      .....|.             . . ...  . | ... |||.... .  ||||||||...
Pvisvspsptvtsggn..vtLtCsaeggpp.....pptisWy.............ietppelqgsegssssestLtissvt.sedsGtYtCvas
Ig_2 Immunoglobulin domain 1441-1540 1.1e-06 20.6 Pfam-A 13-78 (80) alignment 
Range on Protein: 1441-1540
Range on HMM: 13-78/80.0
AGSNLILTCDISvdpnvDTPFtVNVTWTMTgpnsmrlvdtdrinissvmvrsGfNEYRSTLN--FTTLSSIEDSGTYTCIVtivpapaY---EyvmTSDT
.|.|. ||| ..     . |. ..|.|.                        | .|  .. |  |. . | |||||||| .       .   .      .
egenvtLtCqap.....gnpt.pkvqwykd......................g.eelsqsqnalfipnvsaedsGtYtCra.......snseg...skqs

NYMNV
|...|
nsvev
I-set Immunoglobulin I-set domain 2899-2972 1.6e-06 19.8 Pfam-A 12-78 (90) alignment 
Range on Protein: 2899-2972
Range on HMM: 12-78/90.0
VFAGQVYSLNCTVTIVaGVLNITWFNSrGAGLIEGNGISFNLVTvsdtvQRYDLIFNSLEYSDIGVYTCQARLT
|  |.  .|.|||. . . ....|..  |  | . . ....        ..| |.... | || | |||.|.  
vseGesvelectveGe.pepsvsWakd.gselkssqrvkvtvee.....aeytLtIsnvevsDeGkYtckatns
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 5928-6069 1.9e-06 21.6 In-house 149-291 (332) alignment 
Range on Protein: 5928-6069
Range on HMM: 149-291/332.0
KCRQYWPNSTSEvKEFGPFNviLQNTQTYPDLFIRKLSITIQDESSDSHTLIqYQLTSWPDQ-GVPDYA----TSFMSLYRRVINNWSLSKGTILVHCSA
 ||..||. .|. |.|  ..  .| .. . . ... . .|. ..  | .|..  ..  | |   .|.|     .|    | |  ..  .  | |.. |..
icrkfwpekrsk.kdfpals..iqasddhsethmktfnltvtekkqdhqtvl.mhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcat

GVGRTGVFIAVDIALEQAKKEKVVDIAGIVNRLRQQRMKMVQSLDQY
|| .  .. ..|| . .  .|. | .   .. .. ||.  ....  |
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpy
ig Immunoglobulin domain 1574-1638 2e-06 19.0 Pfam-A 3-64 (64) alignment 
Range on Protein: 1574-1638
Range on HMM: 3-64/64.0
NFTLTCTAtkpTIVIPNLVIAWTHNGTIETGTVTTTGGNMTTTVTNTLSFDSSTASDSGTYRCTA
..||||..       |.  . |...|.  .  ..| .  . .. ...| ... | .|||||.|..
svtLtCsv...ssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCvv
I-set Immunoglobulin I-set domain 1331-1406 2.1e-06 19.5 Pfam-A 12-80 (90) alignment 
Range on Protein: 1331-1406
Range on HMM: 12-80/90.0
AEPGEEYMLNCTVTVVDrlivSPVITWTKRsANNVISVPPVLMTVSNvmSSLYLRFSSLNTSDAGLYTCEASINVS
.. ||.  |.|||. .      | ..|.|.  ... |   | .||..  ..  |..|. ..||.| |||.|. .. 
vseGesvelectveGep....epsvsWakd.gselkssqrvkvtvee..aeytLtIsnvevsDeGkYtckatnsag
Ig_3 Immunoglobulin domain 631-715 2.7e-06 19.5 Pfam-A 2-74 (75) alignment 
Range on Protein: 631-715
Range on HMM: 2-74/75.0
PQVSISPSDDSPFIRGtvRTVSCSVVFTPPlptNPNVSFTvfkddeeVPLVNSSRVIAVQTGTTGALTFQPLNFSDAGNYTCTAT
|..|.||| .     .   |..||.. .||   .|..|..           ...     . .. . ||. . ...| |.|||.|.
Pvisvspsptvtsggn..vtLtCsaeggpp...pptisWy.......ietppelqgsegssssestLtissvtsedsGtYtCvas
Ig_2 Immunoglobulin domain 2661-2775 3.1e-06 19.1 Pfam-A 3-80 (80) alignment 
Range on Protein: 2661-2775
Range on HMM: 3-80/80.0
VVTSSLnTTgrIFESNDIQLLCTVTitpldVNHTVNINWFGPNGLITmnntqysisggminPTTNGsSLTFTASLSDNGTdYYCTASVGPAstvngfeli
| ...  |.  ..|. .. | |...      | |... |   . ...              ...|. ...  .|..|.|| | |.|| ..          
vlsapp.tv..vtegenvtLtCqap.....gnptpkvqwykdgeels..............qsqna.lfipnvsaedsGt.YtCrasnseg.........

ipsdTVTSNSATVTV
      .||| .|||
....skqsnsvevtv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 5802-5884 3.1e-06 20.8 In-house 5-87 (440) alignment 
Range on Protein: 5802-5884
Range on HMM: 5-87/440.0
PISLDDLAAHIATCYDSNAFEEQFKNLYDE-EKPCDVGKSNENKALNRLKNITVYDDNRIILTPLSHLeCQTEYINANFVDGYS
|| . |.| ..     | |||...  |     .|.|.    .||  || .|| .|| .|..|  .  .  ...|||| ...|  
piivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgv.pdsdyinasyingie
I-set Immunoglobulin I-set domain 540-608 4.1e-06 18.5 Pfam-A 19-80 (90) alignment 
Range on Protein: 540-608
Range on HMM: 19-80/90.0
SLNCTVTIVaGVLNITWFNSsGTELIEGNGISFNLVTvsdtvQRYDLIFKSLDYSDIGVYTCQARLTVD
.|.|||. . . ....|..  |.|| . . ....        ..| |.... . || | |||.|.  . 
electveGe.pepsvsWakd.gselkssqrvkvtvee.....aeytLtIsnvevsDeGkYtckatnsag
I-set Immunoglobulin I-set domain 3250-3332 4.1e-06 18.5 Pfam-A 9-78 (90) alignment 
Range on Protein: 3250-3332
Range on HMM: 9-78/90.0
VGSVEVGQSLTITCTITTVERLVVTPLITLIKMNDtdmemlsnlNRPYSITTDDigpvINYTLILDPVRFEDAGMYTCMAEFN
   |..|.|....||.. .. . |. .    ...          .. ...| ..     .|||... |. .|.| ||| |. .
dvevseGesvelectveGepepsvsWakdgselks.........sqrvkvtvee....aeytLtIsnvevsDeGkYtckatns
I-set Immunoglobulin I-set domain 655-719 4.7e-06 18.3 Pfam-A 18-80 (90) alignment 
Range on Protein: 655-719
Range on HMM: 18-80/90.0
VVFTPPLPTNPNVSFTVFKDdeEVPLVNSSRVIAVQTGTTGALTFQPLNFSDAGNYTCTATTRDG
| ..     .|. |.. .||  . .| .|.||   ... .  ||..  . ||.|.|||.|| . |
velectveGepepsvsWakd..gselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsag
subfamily_eak_pd Subfamily eak 6154-6262 5.7e-06 19.9 In-house 73-189 (332) alignment 
Range on Protein: 6154-6262
Range on HMM: 73-189/332.0
ALKETDGYINASYLNSYRGKNAFILAQSPMENTVRDFWKMIVDCKVSVIIMLCGEEDC----CYQYWID----SMTYDEFVVKVSSETNASGYIERKLKV
. .. .|||||| ..     . .||.  . |. |  ||.|... |   |..|  . .       .|. |     . .  . |.  .  . . .  |.|..
sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllel

SIDKESRSVLQLQVTDW
|   |.  ||  .|  |
skGnethrvlhykvfGw
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 6253-6316 6.8e-06 20.0 In-house 216-288 (350) alignment 
Range on Protein: 6253-6316
Range on HMM: 216-288/350.0
SVLQLQVTDWPQDGVVREPSTILKIID---------EVREKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALEQ
 |.||||  |.  ... .|  ||....           ..  .. .  |..||||  | | |.....   |..
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsd
Ig_2 Immunoglobulin domain 967-1071 7.2e-06 17.9 Pfam-A 6-80 (80) alignment 
Range on Protein: 967-1071
Range on HMM: 6-80/80.0
PPTGPIYESTSYLLTCTATvnttivnTPVTASVVWTDPSgNVIPTNDTRhqvtpptgnslvsmlLFQPIDTglNNDGGTYTCQMIINSGnsliaSSQSTN
.|  .. |...  |||.|.          |..| |.  . . ....  .               ||.|. .   .|.|||||..   .|     | ||. 
apptvvtegenvtLtCqap.......gnptpkvqwykdg.eelsqsqna...............lfipnvs..aedsGtYtCrasnseg.....skqsns

TTLTV
...||
vevtv
Ig_2 Immunoglobulin domain 2895-2974 7.4e-06 17.9 Pfam-A 8-69 (80) alignment 
Range on Protein: 2895-2974
Range on HMM: 8-69/80.0
AsQPVFAGQVYSLNCTVTiV-AGvLNITWFNSrgagliegnG--------IsfnlvtvsdtvqrydLIFNSLEYSDIGVYTCQARLTVD
  ..|..|.   |.|...   .   ...|            |        .               |. ......| |.|||.|...  
p.tvvtegenvtLtCqap.gnpt.pkvqwykd.........geelsqsqna...............lfipnvsaedsGtYtCrasnseg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 6244-6315 7.7e-06 19.5 In-house 209-290 (349) alignment 
Range on Protein: 6244-6315
Range on HMM: 209-290/349.0
KVSIDKES-RSVLQLQVTDWPQDGVVREPSTILK-------IIDEV--REKQKSGKKGPVVVHCSDTVSRSGVYCSVSIALE
 . ...|.   .||||| .|.  ... .| .||.       .||.   |   .. .  ...||||    |.||.. . . |.
aillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
V-set Immunoglobulin V-set domain 1084-1168 7.9e-06 16.7 Pfam-A 8-101 (114) alignment 
Range on Protein: 1084-1168
Range on HMM: 8-101/114.0
SSVGSVEVGQSLTITCTITtveRlVVTP-MITFIKMND-TDMEMLS---------NLNRPYSITTD--DTGSVTNYTLILDPVRFEDAGMYTCIAEFN
.....|..|.|.|..|. .   . . .  .|...| .. ...| .          .    .| ..    .|| ....| .  .| || |.||| .. .
prpvtvaeGgsvtLpCfys...s.sensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsds
Ig_3 Immunoglobulin domain 1081-1166 9.3e-06 17.8 Pfam-A 4-74 (75) alignment 
Range on Protein: 1081-1166
Range on HMM: 4-74/75.0
VNFSSVGSVEVGQSLTITCTITTVERlvvTPMITFIkmndtdmemlsnLNRPYSITTDDTGSVTNYTLILDPVRFEDAGMYTCIAE
...|. ..|..| ..|.||...       .| |..                |... . .  | .. || . .| .|| | |||.|.
isvspsptvtsggnvtLtCsaeggpp...pptisWy............ietppelqgsegssssestLtissvtsedsGtYtCvas