Gene PTPRD-45 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP101_AA protein Get Run
AqueP101_AA_1967-2181 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2029-2188 4e-86 283.4 In-house 125-301 (301) alignment 
Range on Protein: 2029-2188
Range on HMM: 125-301/301.0
ECCHQYWKESGTADYGEYFVKIESSNEC-------------------NGYIERKIHIRSDKdgSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQ
..|.|||..| . .. ....... .||.                   |||||||....|||  |||||.|.||||||.||.|||| ||||||||||||||
skceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqq

KIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYAN
||||||||||||||||||||||||||.||||||||||||||||||.||.||||||||||||||||||||...|.|||||
kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2029-2180 3.2e-58 192.3 In-house 129-283 (305) alignment 
Range on Protein: 2029-2180
Range on HMM: 129-283/305.0
ECCHQYWKESGTA--DYGEYFVKIESSNECNGYIERKIHIRS-DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVS
..|.||| || |   ..||. |...|... ..|||||..|   |.|  |  |.|.|.|||| .|..... ..|..|..| ..|.|  | |..||||..|.
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
|.||...|.||||..|.|.|||||.|.|..|......|.||.||....|..|   
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
0050432 (Phosphotyrosine protein) phosphatases II 1978-2188 4.9e-53 175.8 In-house 57-307 (308) alignment 
Range on Protein: 1978-2188
Range on HMM: 57-307/308.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILatnpnlDmCQREYINASYVDEC-----------------------------------------------
  ...|.. .|| ..||.|.|  || .|..|      |     |||||||| .                                               
lleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrek

CHQYWKES---GTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSRS
|.||| ..   |.  || ..|.. |  ....|. |.....  .|| |  | .|. |.|| .|.  .|  .|. .. | ...   .|||.|||||. |.|.
caqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRt

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYAN
|... . ..||| ..|| ||||.. | .|. .||.|.|.|||  .|... ...||. |..|
GtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkln
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2029-2186 5.3e-51 168.2 In-house 131-289 (290) alignment 
Range on Protein: 2029-2186
Range on HMM: 131-289/290.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKD-GSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
. |.||| .|.|..|||. .|. . ...|.|||||.......  |..  |.|.|.| |. .| | .| |.|.||  ... | | | ...||||||||.||
vkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrs

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTY
.|.|.. .....|| |||.||||| |  |  ||| |.| .||  |....   ..  .||
avfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
0046845 (Phosphotyrosine protein) phosphatases II 1978-2188 6.5e-50 165.5 In-house 17-282 (284) alignment 
Range on Protein: 1978-2188
Range on HMM: 17-282/284.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNlDMCQREYINASYVDEC-----------------------------------------------
. ...|.. .||   ||.|.| .||..|..| . .. |.   .|||||||| .                                               
llslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelveng

---CHQYWKESG-TADYGEYFVKIESSNECNGYIERKIHIRSDK-DGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQK-IGGGPVVVHCSDTV
   |.||| ..| .  ||...|.. | .....|. |.. ..  . .| |  |..|..|.|| .|.  .|  .|. ...| . ...  ||||.|||||. |
rekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGv

SRSGVYCSVSIALEQCKAEG---VVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYAN
.|.|... . ..||| ..||   .|||... | .|. .||.|.|||||  .|... ...||. |...
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
0040438 (Phosphotyrosine protein) phosphatases II 1976-2186 8e-50 165.3 In-house 30-282 (317) alignment 
Range on Protein: 1976-2186
Range on HMM: 30-282/317.0
GEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVDEC---------------------------------------------
    ...|.. .|| ..||...|  ||..|..|   ..       ||||||||                                               
lkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrek

CHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkiG-GGPVVVHCSDTVSRSGV
|.||| . .|  ||...|.. |  |..|.. |....  ..|. |  | .|. |.|| .|.   | ..|. .. | . ..  . ||||.||||. |.|.|.
caqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTY
.. . ..|||.. || |||... | .|. .||||.|.|||  .||.. ...| . |.
fiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
0051299 (Phosphotyrosine protein) phosphatases II 1979-2180 8.7e-50 165.2 In-house 39-286 (288) alignment 
Range on Protein: 1979-2180
Range on HMM: 39-286/288.0
KPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVD---------------------------------------------ECCHQ
 ...... .|| . ||...|  ||..|..| . ..  .    ||||||.|                                             | |.|
ltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaq

YWKESGTADYGEYFVKIESSNECNGYIERKIHIRSD----KDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGV
|| ..|.  ||...|.. |  ....|. |.....      .|| |  |..|..|.|| .|.   |  .|. . .|.. ..  ||||||||||. |.|.|.
Ywplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
.. . ..||| ..||.|||... | .|. .||.|.|.|||  .|... ...
fialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 1979-2185 5.4e-48 159.2 In-house 29-282 (297) alignment 
Range on Protein: 1979-2185
Range on HMM: 29-282/297.0
KPCTVGYSEENSPFNRFKNITVYDDNRIILatnpnlDMCQREYINASYVDEC---------------------------------------------CHQ
 ...|. ..|| . ||.|.|  ||..|..|      |     |||||||| .                                             |.|
gslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaq

YWKES--GTADYGEYFVKIESSNE--CNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSG
|| .   ..  ||...|.  | ..  ...|. |....   ..| |  | .|..|.|| .|.   | ..|. |. | ...... .||||.||||. |.|||
ywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsg

VYCSVSIALEQCK---AEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHST
... . ..|.| .    || ||.... | .|. .||||.|||||  .|... ...| . |
tfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0047943 (Phosphotyrosine protein) phosphatases II 1978-2180 1.1e-47 158.2 In-house 27-272 (273) alignment 
Range on Protein: 1978-2180
Range on HMM: 27-272/273.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILatnpnlDMCQREYINASYVDE---------------------------------------------CCH
. ...|.. .||  .||.|.|  ||..|..|      ..    ||||||||                                               |.
lltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekca

QYWKESG---TADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSG
||| ..|   .  ||...|.. | .....|. |.. ... ..| |  |..|..|.|| .|.   .  .|. |..| . .... ..||||||||. |.|.|
qYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtg

VYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
... . ..|.| ..|| |||... | .|. .||.|.|.|||  .|... ...
tfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2029-2189 1.6e-47 156.9 In-house 126-287 (287) alignment 
Range on Protein: 2029-2189
Range on HMM: 126-287/287.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDK-DGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
| |.||| |. .  .||| ... . .  .||||||.... .. .|.   | |.|.|.|.  | | || |.| ||.. .. |.| | ...|||||||| ||
evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYANF
...|.. .....|| |||.||||| |  |  |||.| | |||. |.|.. .. .  .||..|
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
0039614 (Phosphotyrosine protein) phosphatases II 1976-2183 2.2e-46 154.1 In-house 44-292 (297) alignment 
Range on Protein: 1976-2183
Range on HMM: 44-292/297.0
GEEkPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDMcQREYINASYVDEC---------------------------------------------
  . ........|| ..||.|.|  ||..|..| .... |.    ||||||||                                               
lkp.dysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrk

CHQYWKESGTaDYGEYFVKIESSNECNGYIERKIHIRSdkDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGV
|.||| |.|.  ||...|.  .  ...||. |.....   .| |  | .||.|.|| .|.   . ..|.... | .....  .||||.||||. |.|.|.
caqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLH
..   ..|||.. || |||... | .|. .||||.|..||  .||.. ...| .
fiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0043336 (Phosphotyrosine protein) phosphatases II 1974-2180 4.2e-45 149.8 In-house 30-277 (278) alignment 
Range on Protein: 1974-2180
Range on HMM: 30-277/278.0
KSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVDEC-------------------------------------------
 |    ........|| ..||.|.|  || .|..|   ..       ||||||||                                             
lsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgr

--CHQYWKeSGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSG
  |.|||  .|.  ||...|.  . .....|. |....   .|| |  | ... ..|| .|.   . ..|. . .|.....   .|||.||||. |.|.|
vkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTG

VYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
... . ..||| . || ||.... | .|. .||||.|..||  .|... ...
tfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 1978-2180 4.8e-45 150.0 In-house 44-304 (307) alignment 
Range on Protein: 1978-2180
Range on HMM: 44-304/307.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLdMCQREYINASYV--------------------------------------------------
  ........|| ..||.|.|  ||..|..| . ..  .    |||||||                                                  
lgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelv

---DECCHQYWKESGTA-DYGEYFVKIESSNECNGYIERKIHIRSD-KDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCS
   .| |.||| ..|.   ||...|.  | ....||. |....    ..| |  |..|. |.|| .|.   . ..|. |. | . ...  .||||.||||
elgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

DTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
. |.|.|...   ..|.| ..||.   ||.... | .|. .||||...|||  .|... ...
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 1980-2179 8.5e-45 148.7 In-house 2-245 (249) alignment 
Range on Protein: 1980-2179
Range on HMM: 2-245/249.0
PCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDMCQreYINASYVD---------------------------------------------ECCHQY
...|.. .|| . ||...|  || .|..|   |.|  .   ||||||.|                                             | |.||
eysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSV
| ..|.  ||...|.  | .....|. |....   .||.|  | ..|.|||| .|.   . ..|. |. | . ....  ||||.||||. |.|.|...  
wplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

SIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMF
 ..||| . |. ||.... | .|. .||||...|||  .|... ..
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 1981-2179 7.6e-41 135.5 In-house 1-242 (245) alignment 
Range on Protein: 1981-2179
Range on HMM: 1-242/245.0
CTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDMCQreYINASYVD---------------------------------------------ECCHQYW
..|.. .|| ..||...|  ||..|..|   ..   .   ||||||||                                             . |.|||
ysvallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

KESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSI
 ....  ||...|.  | . ...|. |....  ..|. |  ||... ..|| .|.   . ..|.... | . ... ..|||.||||. |.|.|... . .
plgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

ALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMF
.||| ..|. |..... | .|. .||||.|..||  .|... ..
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2030-2187 1.9e-40 134.0 In-house 140-297 (298) alignment 
Range on Protein: 2030-2187
Range on HMM: 140-297/298.0
CCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
 .|.|| ..|.. |||  |.. |..|   .| ||... . |  ..  | |...| ||  |. ..  .||.....|   ||. |  ||.|.||. | ||| 
kyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYA
.. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  ...  ....
fiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_PTPRD_pd Subfamily PTPRD 2031-2185 3.8e-40 133.1 In-house 133-286 (564) alignment 
Range on Protein: 2031-2185
Range on HMM: 133-286/564.0
CHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVY
||.|| |.||. |||. |..|...| . |. |.. ..  |. .|  | ||. |.||  |.  .. ..|..|..| . . . . ||.|||||  | |.|..
chkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtf

CSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHST
. ... ||. |.|..||..|. ||.|. ..  | | |||  |...|  . .  .|
ividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
0045098 (Phosphotyrosine protein) phosphatases II 1979-2181 4.3e-40 133.2 In-house 23-273 (278) alignment 
Range on Protein: 1979-2181
Range on HMM: 23-273/278.0
KPCTVGYSEENSPFNRFKNITVYDDNRIIlatnpnldmcqrEYINASYV-------------------------------------------DECCHQYW
  .|..  ..| ..||.|.|  || .|..            .||||||.                                            | |.|||
seitpalylgnldknRykdilpydhsrVk............dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

KESGTADYGEYFVKIESSNECNGYIERKIHIRSD----KDGSSWDVIQFQVTDWPTDGIVREP--LTVLQVIDDVIHRQQK------------IGGGPVV
 |.|.  ||...|...|  ... |. |.....      .|. |. | ... . ||  |.  .|    .|.... . .....             .||||.
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSDTVSRSGVYCSVSIALEQCkaEGVVDVFQVTKAIRRTKPG-AVTTLEQYTSIYDVIDMFFK
||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..||||  .|... ....
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2031-2186 1.7e-38 127.5 In-house 131-286 (318) alignment 
Range on Protein: 2031-2186
Range on HMM: 131-286/318.0
CHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVY
.|.|| ..|.  ||.  |..... |.. |. |..... ..  .| .| |...|.||  |.  .. ..|... .| . ||| | ||.|||||  | | ||.
vhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvf

CSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTY
. |.| ||. |||..|||||. | .|. ..  | | .||. ||||.  . .   |.
iavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2031-2186 4.5e-38 126.1 In-house 133-289 (319) alignment 
Range on Protein: 2031-2186
Range on HMM: 133-289/319.0
CHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGS-SWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
...||.|    .||.. |..|. .| ..|| ||....  ..   . .| .|| |.|| ... .. ...|... .. . ..|   ||.|||||. | | | 
lkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTY
.. ....||. | |||.|||.. . .|  ..  | . |||. ||...  . .  .| 
fivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2028-2187 7.1e-38 125.2 In-house 90-249 (250) alignment 
Range on Protein: 2028-2187
Range on HMM: 90-249/250.0
DECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
.. .||||   ..  ||.  |.. |..|   |. ||. . . |  ..  | |.. . ||  |. ..  .||.....|   ||..| .||.|.||  |.||
ektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrs

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYA
| .. ..  ||. | | |||||.| |..|. .|.||..|||| ..| .|  . .  . ||
Gafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
DSPc_SM00195 2030-2180 1.1e-34 115.4 In-house 110-262 (263) alignment 
Range on Protein: 2030-2180
Range on HMM: 110-262/263.0
CCHQYWKES--GTADYGEYFVKIESSNECN-GYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSR
 |..||.|.  |. ..|.. ||. . ....  .| |..... ...  . .| |.|...||  |.  ..  ||...  | ......  ||.|||||. |.|
kcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
.|......|.|.....|  ||.|.. |..|  .||.|.|||||. ||..|  ..
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2030-2180 1.1e-34 115.4 In-house 110-262 (263) alignment 
Range on Protein: 2030-2180
Range on HMM: 110-262/263.0
CCHQYWKES--GTADYGEYFVKIESSNECN-GYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSR
 |..||.|.  |. ..|.. ||. . ....  .| |..... ...  . .| |.|...||  |.  ..  ||...  | ......  ||.|||||. |.|
kcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
.|......|.|.....|  ||.|.. |..|  .||.|.|||||. ||..|  ..
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0037934 (Phosphotyrosine protein) phosphatases II 1981-2179 2e-34 114.6 In-house 2-241 (243) alignment 
Range on Protein: 1981-2179
Range on HMM: 2-241/243.0
CTVGYSEENSPFNRFKNITVYDDNRIILatnpnlDMcqREYINASYV----------------------------------------------DECCHQY
.... ..|| . ||...|  ||..|..|      .     ||||...                                               | |.||
fsiallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WKesGTADYGEYFVKIESSNECNGYIERKIHIRSDK-DGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSR
|   |.  ||...|.. |......|. |.....  . |. .. ||... . ||  |.  .|  .|. .|.|.  ...        .||||.||||  |.|
wp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

SGVYCSVSIALEQCkaeGvVDVFQVTKAIRRTKPG-AVTTLEQYTSIYDVIDMF
.|...   . |...   | ||.... | .|. .|| ||.|..||  .|... ..
tGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 2030-2176 5.2e-34 113.0 Pfam-A 83-233 (235) alignment 
Range on Protein: 2030-2176
Range on HMM: 83-233/235.0
CCHQYWK--ESGTADYGEYFVKIE-SSN-ECNGYIERKIHIRSDKDGS-SWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQqKIGGGPVVVHCSDTV
 |.|||.  |...  ||...|... ... ....|. ||......|. | .  | |...|.||  |. ..|  .|..|..| ... .   ||||||||. |
kcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
.|.|......|.|||..||. |||.|. | .|. .||.|..||||  .|..|
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 2030-2176 5.2e-34 113.0 In-house 83-233 (235) alignment 
Range on Protein: 2030-2176
Range on HMM: 83-233/235.0
CCHQYWK--ESGTADYGEYFVKIE-SSN-ECNGYIERKIHIRSDKDGS-SWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQqKIGGGPVVVHCSDTV
 |.|||.  |...  ||...|... ... ....|. ||......|. | .  | |...|.||  |. ..|  .|..|..| ... .   ||||||||. |
kcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
.|.|......|.|||..||. |||.|. | .|. .||.|..||||  .|..|
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPRA_pd Subfamily PTPRA 2029-2181 8.7e-34 111.9 In-house 141-296 (330) alignment 
Range on Protein: 2029-2181
Range on HMM: 141-296/330.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDG----SSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGgPVVVHCSDTV
| |.||| . |.  ||.  |..| ..... |  ||. ..   |.    .|  | ||  | ||  |.  ||  .|...  | . .|. .| |.|||||  |
ekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
 |.| .. ..  ||. |||..||||.. | .|  .|  | |.|||. || |.  .. 
GrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2029-2177 1.8e-32 107.7 In-house 131-281 (297) alignment 
Range on Protein: 2029-2177
Range on HMM: 131-281/297.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVR--EPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSR
. | .|| ..|.. .|.  |...| .|..|.|.|..... .|  .   | |.| ..||.. . |  .  ..|..|..| .  ..   ||..|||.  | |
kkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVID
 ||....   . . | |  ||.|.. | .|. .|  | | |||. .| .. 
tgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2029-2176 1.5e-30 101.1 In-house 115-262 (283) alignment 
Range on Protein: 2029-2176
Range on HMM: 115-262/283.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSD-KDGSSWDVIQFQVTDWpTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
. | ||| . |. ||||. | ..     | .| ... .| .    |.  .  .|| || ..     ..  |  .. ||  |..   ||.||||| .. |.
ikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrt

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
.|....| .... ..| |||||.| | .|  ...|| ||.||  .....
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Ptp69D_pd Subfamily Ptp69D 2029-2176 8.6e-29 95.6 In-house 131-282 (307) alignment 
Range on Protein: 2029-2176
Range on HMM: 131-282/307.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGS-----SWDVIQFQVTDWPtDGIVRE-PLTVLQVIDDVIHrQQKIGGGPVVVHCSD
. |..|| .  .  ||.  ||. |..... ||.|....   |. |     |  |.|.. | |. | .| | . ..|..|. | .  .|   .|.||||| 
kkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvre.lyklnrsPivvhCsa

TVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
 |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  .
GvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2030-2179 1e-28 95.1 In-house 128-276 (315) alignment 
Range on Protein: 2030-2179
Range on HMM: 128-276/315.0
CCHQYWKE--SGTADYGEYFVKIESSNECNGYIERKIHIRSDKDgsSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRS
 | ||| .  . ....|.. |.. | . . . . ||. .|  ..  |  | ||| |.||  |. ..  ..|..| .|    ..    ...||||  | |.
kcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrt

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMF
|| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||..   
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_PTPRK_pd Subfamily PTPRK 2031-2176 2.3e-28 93.9 In-house 128-273 (314) alignment 
Range on Protein: 2031-2176
Range on HMM: 128-273/314.0
CHQYWKESGTAdYGEYFVKIESSNECNGYIERKIHIRS--DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSG
| .|| | ..  ||.  |.. ...  . .. |   ..    .      | ||| . ||. ..  .  ..|...  | . |.. . |..|||||    |.|
ClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtG

VYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
... ..| |.  . |||||||.. |..| .|.  | | |||. |||||
tfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPRG_pd Subfamily PTPRG 2030-2176 5.4e-28 92.5 In-house 132-283 (563) alignment 
Range on Protein: 2030-2176
Range on HMM: 132-283/563.0
CCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRS-----DKD-GSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDViHRQQKIGGGPVVVHCSDT
 |..|| . .. .||.  |......    | .|.. |.       |.  .   |.|.. |.||  |    .| ||. .     . .|   ||.|||||  
kcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
|.|.|.|. ..  |.| ..| .|.||.. | ||  ..  |.| |||. ..|..
vgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal
subfamily_PTPN6_pd Subfamily PTPN6 2029-2184 1.3e-27 91.6 In-house 138-301 (306) alignment 
Range on Protein: 2029-2184
Range on HMM: 138-301/306.0
ECCHQYWKESG-TADYGEYFVKIESSNECNGYIERKIHIR-SDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIG---GGPVVVHCSDT
| | .|| ..  . .||.. |.  |... . || |....   .|.... .|.|.. ..||  |. ..| .||. ..|| ..|...     ||.|||||. 
ekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaG

VSRSGVYCSVSIALEQCKAEGV---VDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHS
. | | .  . | |.. . .|.   .|. .. | .|. . | | | .||  .| .| .. . ..
iGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2030-2177 3.6e-27 89.6 In-house 126-273 (515) alignment 
Range on Protein: 2030-2177
Range on HMM: 126-273/515.0
C-CHQYWKE--SGTADYGEYFVKIESSNECNGYIERKIHIRSDKDgsSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSR
  | .|| .  . .  .|.. |.. | . | | | ||...  ..|  |  | ||. |.||  |. ..  ..|..| .|   ....   |...|||  | |
ikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVID
 ||..|.   . . |   .||||.. . ||. .|  | | |||. ||... 
tGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2028-2176 1.1e-26 88.7 In-house 129-284 (325) alignment 
Range on Protein: 2028-2176
Range on HMM: 129-284/325.0
DECCHQYWKES--GTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQK-----IGGGPVVVHC
.. | .|| .    .  .|   ||. . .|   |. |.....  |.| .  | |||.  |.  |  . | |.. ... | . ...      . .|..|||
kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

SDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
|. | |.||. |.  ||..   |  ||.|.. | .|. .|  | | .||. ||. .
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal
subfamily_CG7180_pd Subfamily CG7180 2030-2178 1.7e-25 84.3 In-house 125-288 (296) alignment 
Range on Protein: 2030-2178
Range on HMM: 125-288/296.0
CCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSD-------K---DGSSWDVIQFQVTDWPTDGIV-REPLTVLQVIDDVIHRQQKI----GGG
 ...||.. . ..||| ||.| ....      |....          .   .     | .||.| |. .  |     ......  |   ..|.      |
mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDM
||||..|| .||||||... ..||. . |. ||||.  | .|| .|. | . |.|  ||||.  
PvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2029-2177 2e-25 84.4 In-house 130-276 (288) alignment 
Range on Protein: 2029-2177
Range on HMM: 130-276/288.0
ECCHQYWKESGT-ADYGEYFVKIESSNECNGYIERKIHIRsdKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRS
. |..|| ....   ||.  |.. .|.| . ...||. .   |...  .. |.| . || .|. .    .|.... |   .|.   ||..||||. | |.
tkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrt

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVID
|.. ..  .... ..| ..||. . . .|. ..  | ||.||  ||.|. 
gtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2029-2175 5.1e-25 83.4 In-house 138-286 (319) alignment 
Range on Protein: 2029-2175
Range on HMM: 138-286/319.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRS-DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSR
. | |||   .   .... ||..| .|.. |. |.|..    |     .. ||    ||  |    |  ...... | | ..|  .  ..|||||  | |
dkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDV
.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
tGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1970-2176 5.3e-25 82.6 In-house 26-232 (392) alignment 
Range on Protein: 1970-2176
Range on HMM: 26-232/392.0
THSLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVDE--CCHQYWKES--GTADYGEYFVKIESSNECNGYIERKIH
 | | . .  | ||.  | | . ||.|||  || .|..|      |. ...|.||||..   . . |       .|   ...  .   | .   .  |..
fhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid..dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklk

iRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTT
   ||  .   | ||..|.|| ... .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   ||| .|  | |
.egdkgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqt

LEQYTSIYDVI
 |||. ||  .
keqyafiygav
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2029-2176 7.1e-25 83.1 In-house 102-251 (284) alignment 
Range on Protein: 2029-2176
Range on HMM: 102-251/284.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRS-DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSR
. | |||   .   .... ||..| .|.. |. |.|..    |     .. ||    ||  |    |  ...... | | ..|  .  ..|||||  | |
dkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  .
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2030-2181 1.3e-24 81.7 In-house 114-269 (274) alignment 
Range on Protein: 2030-2181
Range on HMM: 114-269/274.0
CCHQYWKESGTA----DYGEYFVKIESSNECNGYIERKIHIRSDKDgsSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI--GGGPVVVHCSDT
 |..|. ..  .     ||.  .|.|. .|.|.|  ||. ... ..  . .|. .  ||||     ... |.|.....| . ...     .|||||||  
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
. | |.. ..|||. | ..|.||||....  .|  . | | | |||  |. .. .. |
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2030-2179 1.4e-24 81.6 In-house 133-279 (315) alignment 
Range on Protein: 2030-2179
Range on HMM: 133-279/315.0
CCHQYWKESgTADYGEYFVKIESSNECNGYIERKIHIRSDKdgSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGV
 . .|| .     ||.. |   | .  . |  | . . ...     .|.|...| ||. |. .  ......|  |   ...   |..|||||. | |.| 
kaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI-DMF
.....  |.| .|| ..||... . .|. . ..| ..|||  |||.. . |
fitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2031-2177 4.5e-24 80.0 In-house 126-273 (281) alignment 
Range on Protein: 2031-2177
Range on HMM: 126-273/281.0
CHQYWKESG-TADYGEYFVKIESSNECNGYIERKIHIrSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
||.|| .   .  ||.. || ....| . |||||... . ..| . .| |.. | ||  |.  ..  .|.  ..| . ..|    |.|.|||  | |.|.
ChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGt

YCSVSIALEQCKAE-GVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVID
| ..  ......||   .|| .| . .|...   | |. ||. .| .. 
yialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavl
subfamily_PTPRB_pd Subfamily PTPRB 2031-2179 4.5e-24 80.0 In-house 136-284 (293) alignment 
Range on Protein: 2031-2179
Range on HMM: 136-284/293.0
CHQYWKES-GTADYGEYFVKIESSNECNGYIERKIHIRSdkDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRSG
|..|| .   .  ||.  |.. ...| . .. |...|.   . .. .| |.. | ||  |.  .. |.|. .  | ... ..   .|.|||||  | |.|
CeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtG

VYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMF
.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .
tfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
PTPc_DSPc_SM00012 2077-2176 1.5e-23 78.3 In-house 2-103 (105) alignment 
Range on Protein: 2077-2176
Range on HMM: 2-103/105.0
VIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKAIRRTKPGAVTTLEQYTSIYD
| ....|.||  |. .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..|.|.|...| . ||.||. |..|. .||.|.|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al
subfamily_PTPN3_pd Subfamily PTPN3 2031-2176 1.6e-23 78.0 In-house 126-271 (280) alignment 
Range on Protein: 2031-2176
Range on HMM: 126-271/280.0
CHQYWKES-GTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGV
||||| |.  . .|||. ||.|...| . |. |.. ..  .   .  ..|.| ..||  |.  ..  .|.... | .....    |||||||  . |.||
ChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGv

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
.  . .||    |.  | . .. . .|  .   | | .||. . . |
lilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_PTPN12_pd Subfamily PTPN12 2031-2181 2.1e-23 77.6 In-house 125-278 (290) alignment 
Range on Protein: 2031-2181
Range on HMM: 125-278/290.0
CHQYWKESGTAD--YGEYFVKIESSNECN-GYIERKIHIRSDkdGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRS
|..|| |.|  .  .||. |. |. . .. ... | .... .  . |  | ||. |.||  |. . . ..|..|..| ..|.     |.|||||  | | 
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrt

GVYCSVSIALEQCKAEGV---VDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
|. ... .. |. ||| .   .|||..   .|. .. .| | |||. .|  .  ...
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2030-2181 1.4e-22 75.0 In-house 105-265 (270) alignment 
Range on Protein: 2030-2181
Range on HMM: 105-265/270.0
CCHQYWKESGTA--DY--GEYFVKIESSNECNGYIERKIHIRsdKDGSSWDVIQFQVTDWPTDGIVREPL------TVLQVIDDV-IHRQQKIGGGPVVV
 | .|| ..     ..  |.  |  .|..  .||| ......  ..|..  .. |. ..|| .|..||.        .|... .|  .....  ..|..|
kCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

HCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
|||. | |.|.   . ||..  . .. ||| .. ...|. ..  | . |||. .| .. .. .
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1970-2030 1.5e-22 74.7 In-house 21-81 (301) alignment 
Range on Protein: 1970-2030
Range on HMM: 21-81/301.0
THSLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDMCQREYINASYVDEC
 ..||.||.|.||||.||||...||||||||||||||||...||||.||||||||||.|..
ykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgy
subfamily_PTPN13_pd Subfamily PTPN13 2031-2176 5.2e-21 70.1 In-house 119-265 (273) alignment 
Range on Protein: 2031-2176
Range on HMM: 119-265/273.0
CHQYWKESGT---ADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRS
||.|| ||       .. . |. .  .. .|.  |.....  . | | .| ... ..||  |. .... .||..  | . |.    ||.|||||  . ||
chrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrs

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
|.. .. ..|.  . .  .|| .. . .|. . | | | .||  .| .|
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_PTPN23_pd Subfamily PTPN23 2029-2176 5.4e-21 69.7 In-house 123-276 (288) alignment 
Range on Protein: 2029-2176
Range on HMM: 123-276/288.0
ECCHQYWKE--SGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIH---RQQKIGGGPVVVHCSDT
. ...|| |    |  .|.. | ..| .| . ..||.....  .     .|   |.| ||  |.   | |.||..| | .    .|.    |.|||||  
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaG

VSRSGVYCSVSIALEQC-KAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
| |.||.. |  |...  | .|..|. || . .|. .   | . ||.   |...
vgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_PTPN9_pd Subfamily PTPN9 2031-2176 5.6e-21 69.8 In-house 127-286 (297) alignment 
Range on Protein: 2031-2176
Range on HMM: 127-286/297.0
CHQYWK--ESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQ------------KIGGGPV
| |||.  |  .|..|.. |.  . .| . | .|...|.  |.. |  |. ||.. ||  |. ..  ..|.|.. | ..|             .. | |.
cgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPi

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
|||||  . |.| .... |.|.. . .|.|||... | .|  .  .. | |||.  |  .
vvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
0051429 (Phosphotyrosine protein) phosphatases II 2021-2181 5.9e-21 70.8 In-house 6-226 (272) alignment 
Range on Protein: 2021-2181
Range on HMM: 6-226/272.0
YINASYVD-----------------------------------------------ECCHQYWK------------ESGTADYGEYFVKIESSNECNGYIE
||||..|.                                               . |..||             .  |  || ..|.. |   .. || 
yiNardvggygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyil

RKIHIRSD-KDGSSWDVIQFQVTDWPTDGIVREPltVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVD--------VFQVT
|.. ..   . | .  | ... ||||..|. .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||        .... 
rellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeav

KAIRRTKPGAVTTLEQYTSIYDVIDMFFK
. .|.  |||| | |||  .|...  ...
eelraqrpgavqteeqylflyeallellr
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2029-2176 2.2e-20 67.9 In-house 85-235 (237) alignment 
Range on Protein: 2029-2176
Range on HMM: 85-235/237.0
ECCHQYWKESG-TADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVI-QFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVS
. ||.|| ..   | || . | .   .|   |  | . .          .| |.| | ||  |. ..  ..|.   ..|.| ...   || ..|||  | 
lkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
|.|..  .   | |.| . |||...  ..|   .|  . | .||  |...|
rtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2030-2173 2.4e-19 64.5 In-house 93-234 (239) alignment 
Range on Protein: 2030-2173
Range on HMM: 93-234/239.0
CCHQYWKESgTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGV
 ||||| .| |. | .  | .  ..    || | . .    .     | |...| ||  |. .   .|| .    | ..   |  | |.|||  | |.| 
kchqywpds.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIY
.  .   | |.| .  ||.|.  ||||  .|  | | |||  |.
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2030-2173 2.5e-19 64.4 In-house 92-233 (239) alignment 
Range on Protein: 2030-2173
Range on HMM: 92-233/239.0
CCHQYWKESgTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGV
 ||||| .| |. | .  | .  ..    || | . .    .     | |...| ||  |. .   .|| .    | ..   |  | |.|||  | |.| 
kchqywpds.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIY
.  .   | |.| .  ||.|.  ||||  .|  | | |||  |.
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
0036282 (Phosphotyrosine protein) phosphatases II 2029-2174 1.3e-18 62.7 In-house 52-164 (174) alignment 
Range on Protein: 2029-2174
Range on HMM: 52-164/174.0
ECCHQYWKEsgtadygeyfvkiessnecngyierkihirsDKDGSSWDVIQFQVTDWPTDGIVREPLtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
. |..|| |                               ...  .  .||.. . || .|    .  .|.... | . ... .||||.||||  |.|.|
ykcinywpe...............................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtG

VYCSVSIALEQCKaEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYD
. .   . | . . |..||.... ...|. .||.|.| .||  .|.
tlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0041856 (Phosphotyrosine protein) phosphatases II 1989-2181 1.5e-18 62.5 In-house 1-172 (182) alignment 
Range on Protein: 1989-2181
Range on HMM: 1-172/182.0
NSPFNRFKNITVYDDNRIILATNPNLDMCQREY-----------------------------INASyvdecCHQYWKesgtadygeyfvkiessnecngy
| . ||...|  || .| .   |.|| .. .                               .|..     ...||                        
nldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp.......................

ierkihirsdkDGSSWDVIQFQVTDWPTDGIVRePLTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGvVDVFQVTKAIRRTK
           .     .||.. . || .|.   . ..|. |..|..      ||||.||||  |.|.|...   . ...    | |..... | .|. .
...........ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrR

PGAVTTLEQYTSIYDVIDMFFK
||.|.|..||  ..... ....
pgmvitpnqyfflqlallelll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2032-2176 3e-18 60.5 In-house 129-275 (439) alignment 
Range on Protein: 2032-2176
Range on HMM: 129-275/439.0
HQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGS--SWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
..||  .. . ||.  |...   |   |. | ...  ..| .     |.||. . ||   .  .   ||. .  .   ..|   ||||||||  | |.| 
ykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
  .. ||||| |.|  ||.  . | .|. .   | .| ||  ||. .
iialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_PTPN14_pd Subfamily PTPN14 2030-2181 9.6e-18 59.2 In-house 134-297 (300) alignment 
Range on Protein: 2030-2181
Range on HMM: 134-297/300.0
CCHQYWKES----GTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTV---LQVIDDVIHRQQKIG-----GGPVV
 ...|. ..     |...|.. |  . |.. . .| ......    .   .|. .| |||| .|. ... .    |. .. | .. ..         ||.
ksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.|.  ..|
vhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0049772 (Phosphotyrosine protein) phosphatases II 1968-2181 1.1e-17 60.3 In-house 25-281 (314) alignment 
Range on Protein: 1968-2181
Range on HMM: 25-281/314.0
LNTHSLKSGEEKPCTVGYSEENSPFNRFKNITVYDdNRIILatnPNLDMCQREYINASYVDECcHQY------------------------WKES-----
||..||    |. ..|.. ..|   ||...|  .| || ||   |.|..    |||||||| .  ..                        |. .     
lnrrslsvlpeltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdl

--------------------------------------GTADYGEYFVkiessnecngyierkiHIRSDKDGSSWDVIQFQVTDWPTdGIV---REPLTV
                                       || . |..                  .  |..  .  .|..  ...|  | .   .  . .
nvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk................eelydpelferlgikylripvpD.gsaplledfdef

LQVIDDVihrqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaeGVvDVFQVTKAIRRTKP-----GAVTTLEQYTSIYDVIDMFFK
|..|...        ||||.|||.. ..|.|... . . . ..   || .. .. . .|.. |     |.. .||||  |.... ...|
lefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk
0043147 (Phosphotyrosine protein) phosphatases II 2020-2174 3.7e-15 51.5 In-house 6-155 (172) alignment 
Range on Protein: 2020-2174
Range on HMM: 6-155/172.0
EYINASYVDEC-------CHQYWKESGTADYGEYFVKIESSNecngyIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVrEPLTVLQVIDDVIHRQQKIG
 ||||||.| .       ..|.   . .||. ... .   .      | .      |... .  .||.. . ||  |    .  .|.... . .....  
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgith.....ivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalsp

GGPVVVHCSDTVSRSGVYCSVSIALeqckaeG-VvDVFQVTKAIRRTKPGAVTTLEQYTSIYD
||||.||||  |.|.|. .   . |        . ..... . .|. .||||.. .||  .|.
ggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyy
subfamily_PTPRN_pd Subfamily PTPRN 2030-2174 5e-15 50.0 In-house 141-286 (297) alignment 
Range on Protein: 2030-2174
Range on HMM: 141-286/297.0
CCHQYWKESGTADYGEYFVKIESSN-ECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRSG
 |..|| . |.. |. | |.. |    |. |. | ....  .   .  | ||    ||  |.  .. ..|.    |  .  .    |.|||||| . |.|
qckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtG

VYCSVSIALEQC-KAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYD
||. . . |..  |    .|.    . .|  .|| | | .|.  .. 
vyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
0051082 (Phosphotyrosine protein) phosphatases II 2021-2175 6.6e-15 50.5 In-house 5-148 (151) alignment 
Range on Protein: 2021-2175
Range on HMM: 5-148/151.0
YINASYVDE----------------------------------CCHQYWKESGtadygeyfvkiessnecngyierkihirsdkdgssWDVIQFQVTDWP
|||.|||..                                   |..|..| |                                    .|......|||
yinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg...................................ievlhipildwp

TDGIVREPLTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaegvVDVFQVTKAIRRTKPGAVTTLEQYTSIYDV
. |.   . .||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
dpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2076-2175 7.1e-15 49.2 In-house 90-189 (440) alignment 
Range on Protein: 2076-2175
Range on HMM: 90-189/440.0
DVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDV
 . |..   ||  |. .    ||..|.|| . |.| | ||..||||  ..|.||  .|   | ..|    .|.| . ...|  .|  | | |||. ....
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2070-2175 9.3e-15 49.3 In-house 151-254 (267) alignment 
Range on Protein: 2070-2175
Range on HMM: 151-254/267.0
KDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIddVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQY
|. |. .|  .    |  .   .  |  |  |  . . | . |. |.||.||| | ||| .  .   ||. | |||.|.|.  . ||  ..| | |.|.|
knesahnvtlyyykkwnintnnkpylkplfgi..laknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkery

TSIYDV
  |...
iyihel
subfamily_PTPN1_pd Subfamily PTPN1 2031-2173 5.3e-14 46.6 In-house 113-264 (290) alignment 
Range on Protein: 2031-2173
Range on HMM: 113-264/290.0
CHQYWKESGT-----ADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQ-KIGGGPVVVHCSDTV
|.||| .         .  .. ||. | .. . |. |....   |   . ....|  | ||  |. . | . |. . .| .    .   ||.|.|||  .
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

SRSGVYCSVSIALEQCKAEGV---VDVFQVTKAIRRTKPGAVTTLEQYTSIY
 ||| .| |   | . ....    ||. .|  ..|. . | . | .|    |
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
0048076 (Phosphotyrosine protein) phosphatases II 2059-2178 1.5e-13 46.2 In-house 29-141 (145) alignment 
Range on Protein: 2059-2178
Range on HMM: 29-141/145.0
YIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiALEQCKAEGvVDVFQVTKAIRRT
 | . . . |.... .  .||.. ..||  |.   . ..|.... . . ...  ||||.||||  |.|.|...    |.  .. .| |..... . .|. 
gittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsq

KPGAVTTLEQYTSIYDVIDM
 ||||.. .|.  .|... .
rpgavpnpgqlrflyefele
0049260 (Phosphotyrosine protein) phosphatases II 2027-2174 2.2e-13 45.6 In-house 47-144 (152) alignment 
Range on Protein: 2027-2174
Range on HMM: 47-144/152.0
VDECCHQYWkesgtadygeyfvkiessnecngyierkihirsdkdgsswdviQFQVTDWPTDGiVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSR
  ..|.||.                                           |.. . || .| | .   .|. . ..|.. ..  ||||.||||  |.|
gklkceqyi...........................................qylhlpwpDhg.vpdlsqlllflllfieklaldkggpvlVHCsaGvgR

SGVYCSVSIALeqckaeGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYD
.|...   . |        |..... . .|. .||||.. .|.  .|.
tgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 2031-2180 3.4e-13 45.2 In-house 65-173 (176) alignment 
Range on Protein: 2031-2180
Range on HMM: 65-173/176.0
CHQYWKESGTADYgeyfvkiessnecngyierkihirsdkdgsswdviQFQVTDWPTDGIVREpLTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVY
|..||.|  ....                                   |.....||  |.      .|.... .  ....  ||||.||||  ..|.|..
cpnywpeleklgi...................................qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtl

CSVSialeQCKAEGVVDVFQVTKAIRRTKP-GAVTTLEQYTSIYDVIDMFF
.        .. |  ..|... . .|. .| |||.| |||  .|... ...
vaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2031-2176 5.7e-13 43.2 In-house 136-279 (290) alignment 
Range on Protein: 2031-2176
Range on HMM: 136-279/290.0
CHQYWKES--GTADYGEYFVKIESSNEC-NGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVihRQQkigGGPVVVHCSDTVSRS
|.||. |    .  .||. |    ...  .  | . . .|  ..| .  .  ...  ||   .    |..|...  .  |.     ||||||||  . |.
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrt

GVYCSVSIALeQCKAEG-VVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
| . .. ..| |.  .|  .|. .. .|.|... ..|    ||  . ...
Gtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil
fn3 Fibronectin type III domain 1383-1457 6.5e-13 41.8 Pfam-A 2-79 (85) alignment 
Range on Protein: 1383-1457
Range on HMM: 2-79/85.0
APSSFTVVSKTATTINVSWTALD--SSDADGYVVNVTSDTDTV--QTVQVKGSnTNAITLNGLRELTTYNITVRAYQQL
||. ..| . |.|....||.. .  ... .|| | . .....   ....|... |.  ||.||.. |.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprt.ttsvtltgLkpgteYefrVqavnga
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2016-2180 1.1e-12 42.7 In-house 98-259 (290) alignment 
Range on Protein: 2016-2180
Range on HMM: 98-259/290.0
MCQREYINASYVDECCHQYWKESG--TADYGEYFVKIESSNECNGYIERKIHIRSDkDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQqkigg
.|..|  .|   .. | .| .||      ..   ||  |  . .. ..|.. .. | |.  . |   .. .| .  . ....|.|..|. |  ..     
lcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvkask.....

GPVVVHCSDTVSRSGVYCSVSIALEQCK-AEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
 ||.||| | .||| .  .. ..       .| | . .| ||.|. .  |.|. .... .  .| . .
tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivlla
0044763 (Phosphotyrosine protein) phosphatases II 2015-2181 2e-12 42.6 In-house 14-172 (178) alignment 
Range on Protein: 2015-2181
Range on HMM: 14-172/178.0
DMCQREYINASYVDEC------------------------------------CHQYWKESGTadygeyfvkiessnecngyierkihirsdkdgssWDVI
...  .|||||....                                     |..|| |.                                    . ..
glersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeag..................................iqyl

QFQVTDWPTDGIVREPLTVLQVIDDVIhrqqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGVvDVFQVTKAIRRTKPgAVTTLEQYTSIYDVIDM
.. . |...  . .  | ... |....    .  ||||.||||  |.|||. .   . ...    |. ..... . .|. .| .|.. .|.  .|..  .
hipipDhgvpdllehflefvefieeal....dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr

FFK
..|
llk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1973-2029 2.1e-12 41.5 In-house 29-86 (290) alignment 
Range on Protein: 1973-2029
Range on HMM: 29-86/290.0
LKSGE-EKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDMCQREYINASYVDE
|.||| |.  ||| ...|.. |||.|| |||||||.|   ..   |. |||||.|...
ldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikg
subfamily_CG42327_pd Subfamily CG42327 2112-2181 2.2e-12 41.3 In-house 246-316 (319) alignment 
Range on Protein: 2112-2181
Range on HMM: 246-316/319.0
GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
  ||.|||||| | |.|.  .  ||... .     ||. |.   .|| .  || | |||  || |. .. |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
0048179 (Phosphotyrosine protein) phosphatases II 2064-2174 3.9e-12 41.6 In-house 48-139 (144) alignment 
Range on Protein: 2064-2174
Range on HMM: 48-139/144.0
IhirsdkdgsswdVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIALeqckAEGvVDVFQVTKAIRRTKPGAV
             .||.. ..||  |.   .  .|.... . . ..   ||||.||||  |.|.|...   . .     .| ...... . .|.  ||||
e............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgav

TTLEQYTSIYD
.. .|.  ...
pnpgqlrfLle
fn3 Fibronectin type III domain 259-332 7.7e-12 38.4 Pfam-A 3-79 (85) alignment 
Range on Protein: 259-332
Range on HMM: 3-79/85.0
PSSLTEVSKTATTITVSWTALD--SSDADGYVVNVTSNTDT--VQTVQVEGSSNnTITLNGLRGGTTYSITVRAYQQL
|. |.  . |.|..|.||.. .  ... .|| | . . ...   ....|..... . ||.||. ||.|...|.|. . 
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2034-2175 8.6e-11 36.4 In-house 50-199 (199) alignment 
Range on Protein: 2034-2175
Range on HMM: 50-199/199.0
YW--KESGTADYGEYFVKIESSNECNGYIERKIHIRS--DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRS
||   ||||. ||   |  ..      |    . . .      |. .. ..| | |         | |  |.   .| .. ..    ||.|||||    .
ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgft

GVYCSVSIALE---QCKaEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDV
||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
gvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2034-2175 8.6e-11 36.4 In-house 49-198 (198) alignment 
Range on Protein: 2034-2175
Range on HMM: 49-198/198.0
YW--KESGTADYGEYFVKIESSNECNGYIERKIHIRS--DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRS
||   ||||. ||   |  ..      |    . . .      |. .. ..| | |         | |  |.   .| .. ..    ||.|||||    .
ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgft

GVYCSVSIALE---QCKaEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDV
||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
gvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
fn3 Fibronectin type III domain 580-654 1.2e-10 34.5 Pfam-A 2-79 (85) alignment 
Range on Protein: 580-654
Range on HMM: 2-79/85.0
APSSLTDINNTATTITVSWTALD--SSHANGYVVNVTSDTGT--VQTVQVEGNSNnTITLNGLRGEIIYSITVRAYQQL
||. |. ...|.|..|.||.. .  ...  || | . ...|.   ....|..... . ||.||.    |...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2031-2183 1.2e-10 35.7 In-house 122-280 (287) alignment 
Range on Protein: 2031-2183
Range on HMM: 122-280/287.0
CHQYWKESGT-ADYGEYFVK-IESSNECNGYIERKIHIRsDKDGSS-WDVIQFQVTDWPTDGIVREPLTVLQVIDDV----IHRQQKIGGGPVVVHCSDT
|..|| |       | | |  .. ..    |  | . .  | ..     | |... .|| ...    . ... . ||      ...  . ||.|||..  
cykywPerevPmrvGGysvvlldydikePeygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLH
. |||.. .. . ... .  | ||| .|   .|  . . | .  |.  .|. .  ..|  
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1972-2028 3.5e-10 34.5 In-house 30-83 (305) alignment 
Range on Protein: 1972-2028
Range on HMM: 30-83/305.0
SLKSGeEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVD
|| .  |... || .|.|   ||.|.||..||.||||.....||  ...||||||||
slyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvd
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2067-2187 7.6e-10 33.3 In-house 168-286 (307) alignment 
Range on Protein: 2067-2187
Range on HMM: 168-286/307.0
RSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIALEQ-CKAEGVVDVFQVTKAIRRTKPGAVTT
. |  . |  . ..| ..||  |. .  || . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |
kvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqt

LEQYTSIYDVID-MFFKLH-STYA
  ||  .. |.   |..|.  ||.
eaqylylhrvlleyflelyketye
fn3 Fibronectin type III domain 935-999 2e-09 30.6 Pfam-A 18-85 (85) alignment 
Range on Protein: 935-999
Range on HMM: 18-85/85.0
LTWNEVNcsERNGLITGYTVMISNS-----GVTYNLTSTERYIILNDLVFGTEYNISVAAVNSAGRGPFS
|.|.. .  ...| ||||.|  ...      .......|..  .|..|  ||||...|.||| || ||.|
lsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 1667-1731 5.6e-09 29.2 Pfam-A 18-85 (85) alignment 
Range on Protein: 1667-1731
Range on HMM: 18-85/85.0
LTWNEVNcsKHDGLITGYTVMISNS-----SITYNLTSTERYIILNDLAFGTKYNISVAAVNSAGRGPFS
|.|.. .  . .| ||||.|  ...     . ......|..  .|..|  ||.|...|.||| || ||.|
lsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_PTPRD_pd Subfamily PTPRD 1972-2028 1.2e-08 29.1 In-house 31-85 (564) alignment 
Range on Protein: 1972-2028
Range on HMM: 31-85/564.0
SLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLdmCQREYINASYVD
....|.. ....   ..| . ||..||. || .|..| . ..    . .|||||..|
kieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfid
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2074-2172 2.4e-08 27.8 In-house 189-280 (302) alignment 
Range on Protein: 2074-2172
Range on HMM: 189-280/302.0
SWDVIQFqvTDWPTDGIVREPLTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSI
. |...|  . ||  |  .|. | |...      ...     |.||||  | |.|   ..   .. |. . | |. .. . .|. . ||| . .| . .
tvdilaf..sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1978-2028 3e-08 28.0 In-house 36-80 (287) alignment 
Range on Protein: 1978-2028
Range on HMM: 36-80/287.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILAtnpnldMCQREYINASYVD
|.  |.. ...| . ||...| |.|..|..|        .. .||||...|
edevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfid
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2071-2181 3.8e-08 27.4 In-house 182-288 (305) alignment 
Range on Protein: 2071-2181
Range on HMM: 182-288/305.0
DGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVV-DVFQVTKAIRRTKPGAVTTLEQY
 ...  | ..   |||  |.    |..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  .. . ||  .  .. | .||
gekarkvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqy

TSIYDVIDMFFK
  ...||  .|.
lfvhqvilnyfr
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1974-2030 4.7e-08 27.1 In-house 33-84 (95) alignment 
Range on Protein: 1974-2030
Range on HMM: 33-84/95.0
KSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDmcqreYINASYVDEC
      | ||| || | | ||| ||  ||  |..|.|. . |     |||| .||  
smtsgapytvgsseanipknrflnifpydatrvvlttkrdsd.....yinacfvdgy
fn3 Fibronectin type III domain 1748-1839 6.6e-08 25.8 Pfam-A 8-84 (85) alignment 
Range on Protein: 1748-1839
Range on HMM: 8-84/85.0
VSSIvDTTWAVISWSKPIyiPSDYPIITYEIGYHALESGNcsmayddditpeILNLSNVSSNDTFTIITGLNSNTCYIFGIRAYSDNGYGAW
||..  .| ...|||.|   . . ||  ||. |   ..|.              .  .|... |  ..|||. .| | | ..|....|.| .
vsev.tstsltlsWsppk..dgggpitgYeveyrekggge............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 1016-1108 8.1e-08 25.5 Pfam-A 8-85 (85) alignment 
Range on Protein: 1016-1108
Range on HMM: 8-85/85.0
ASSImDTTWAIISWSVPSyiPSDYPIITYEIGYHALESGNcsmvydddinpqVLNLFNVSSNDTFTTITGLNSNTCYIFGIRPYSDNGYGEWT
.|..  .| . .||| |.  . . ||  ||. |   ..|.            . . |.|... |  |.|||. .| | | .. ....|.|...
vsev.tstsltlsWsppk..dgggpitgYeveyrekggge............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2115-2176 9.3e-08 26.3 In-house 230-291 (297) alignment 
Range on Protein: 2115-2176
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||||.. .||..
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2083-2185 9.5e-08 25.8 In-house 189-290 (302) alignment 
Range on Protein: 2083-2185
Range on HMM: 189-290/302.0
TDWPTDGIVREPLTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKL
| |. . .  .  .. . . .| . ..  .  ..|.     . | |.  .. .|.|. ...  . . .. |.||  .| || .|.||.|.| .. ...| 
tnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk

HST
. |
kvt
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2077-2177 1.1e-07 25.9 In-house 169-266 (281) alignment 
Range on Protein: 2077-2177
Range on HMM: 169-266/281.0
VIQFQVTDWPTDGIVREPLTVLQviddvIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKAIRRTK-PGAVTTLEQYTSIYD
. ..   .||   .      .|.     | |. .    | |.|||  | |||   .| |||.  ..   . |. |.   .| |    .| ||.||  |. 
ithwlwkewpdwqvpessevmlk.....ilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwk

VID
|. 
vll
DSPc_SM00195 1972-2028 2e-07 26.0 In-house 9-63 (263) alignment 
Range on Protein: 1972-2028
Range on HMM: 9-63/263.0
SLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLdmCQREYINASYVD
...| ..|..| .  ..|.  ||.||| .||..|..| ....    . .||||.|..
leestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyik
PTPc_SM00194 1972-2028 2e-07 26.0 In-house 9-63 (263) alignment 
Range on Protein: 1972-2028
Range on HMM: 9-63/263.0
SLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLdmCQREYINASYVD
...| ..|..| .  ..|.  ||.||| .||..|..| ....    . .||||.|..
leestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyik
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2117-2177 2.6e-07 24.9 In-house 2-62 (69) alignment 
Range on Protein: 2117-2177
Range on HMM: 2-62/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVID
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| . 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1974-2028 4.5e-07 24.3 In-house 25-78 (281) alignment 
Range on Protein: 1974-2028
Range on HMM: 25-78/281.0
KS-GEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVD
.. | ... |  ...||   ||..||. ||  |. .. | .    . .||||..|.
aaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvp
subfamily_PTPN6_pd Subfamily PTPN6 1983-2028 5.6e-07 23.9 In-house 48-90 (306) alignment 
Range on Protein: 1983-2028
Range on HMM: 48-90/306.0
VGYSEENSPFNRFKNITVYDDNRIILAtnpNLDMCQREYINASYVD
 |   ||   ||.|||  .|..|.||.   . .. . .||||.|..
egakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyik
subfamily_ptpA1_pd Subfamily ptpA1 2060-2138 6.4e-07 23.4 In-house 173-254 (418) alignment 
Range on Protein: 2060-2138
Range on HMM: 173-254/418.0
IERkiHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIALE
| |   ||   .| . |. |.|   ||   |      . |..  .  ||..|        |..||||  | |.| .|.  | ..
itr..nirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2117-2181 8.9e-07 23.2 In-house 1-65 (69) alignment 
Range on Protein: 2117-2181
Range on HMM: 1-65/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| .   .|
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
fn3 Fibronectin type III domain 776-835 1.1e-06 21.9 Pfam-A 11-78 (85) alignment 
Range on Protein: 776-835
Range on HMM: 11-78/85.0
LNATSIKVNWTNS----SEANGYVIEYTTGGVT--RNVLSTSEDE--IVLTNLSSMSTYTISVYSYTD
 ..||. ..|. .    ..  || .|| . | .   .  ......   .||.|   ..|...|.....
vtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavng
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1976-2028 1.1e-06 22.9 In-house 35-85 (319) alignment 
Range on Protein: 1976-2028
Range on HMM: 35-85/319.0
GEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVD
....  .    |||.. ||..||  ||  |..|.. ..  . . .|||||..|
avndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfid
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2077-2176 1.3e-06 22.7 In-house 173-267 (288) alignment 
Range on Protein: 2077-2176
Range on HMM: 173-267/288.0
VIQFQVTDWPTDGIVREPLTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
| .  . .|. ||.  . |. |.... . .  ||    |.|||.|  | |.|    . ||||. . .  . . .. .  |  .  |..|  ||  .. ..
vkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_Ptp69D_pd Subfamily Ptp69D 1978-2028 1.5e-06 22.5 In-house 37-85 (307) alignment 
Range on Protein: 1978-2028
Range on HMM: 37-85/307.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVD
.| ..|.  .||   ||...|. .|..|..|.. .  .  . .|||||.. 
dkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfik
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2075-2180 1.8e-06 21.8 In-house 188-289 (305) alignment 
Range on Protein: 2075-2180
Range on HMM: 188-289/305.0
WDVIQFQVTDWPTDGIVREPLTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIALEQCKA-EGVVDVFQVTKAIRRTKPGAVTTLEQYTSIY
  | ..| |.||  |.    || |...  .  |  |.   |.|||||  . |.|   ..   ||.      .  . .. ||.|  .  .. .  ||  |.
msvrhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfih

DVIDMFF
 |.  .|
rvmlnyf
subfamily_egg_pd Subfamily egg 2084-2181 4.8e-06 20.5 In-house 180-271 (307) alignment 
Range on Protein: 2084-2181
Range on HMM: 180-271/307.0
DWPTDGIVREPLTVLQVIddvihrqqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVV--DVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
|.   . |  || ||. .        .    ||||.. . ||....  .. ||| .     ..   | .  . .|. .. .| .  .|  .| .. .||.
dvnnssdvysplrvlrkl........rnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1970-2028 5.3e-06 20.5 In-house 25-81 (315) alignment 
Range on Protein: 1970-2028
Range on HMM: 25-81/315.0
THSLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVD
 | |   .  . .|.  ..| . ||.|||  .| .|..|      |  ...||||||. 
fhdlpdPdiyrqrvaretinfkknryknilPldsarvklevid..dsPdsdyinasyik
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2109-2179 6.2e-06 20.0 In-house 219-289 (310) alignment 
Range on Protein: 2109-2179
Range on HMM: 219-289/310.0
QKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMF
 ..  ||.|||||  . | .| ... ..... .    ||. .|   .....   . |  ||. |  |  .|
aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_PTPRB_pd Subfamily PTPRB 1976-2028 8.3e-06 20.0 In-house 38-88 (293) alignment 
Range on Protein: 1976-2028
Range on HMM: 38-88/293.0
GEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVD
|... ...  ...|.  ||..||  || .|. ||.    |  . .||||.|..
gkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyip
subfamily_PTPN12_pd Subfamily PTPN12 1972-2028 8.9e-06 19.8 In-house 23-77 (290) alignment 
Range on Protein: 1972-2028
Range on HMM: 23-77/290.0
SLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVD
 .|. .. . ..| .|||   ||.|.|  || .|. | .. . .  . .||||... 
kykaekvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfik