Gene PTPRD-45 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP101_AA protein Get Run
AqueP101_AA_1967-2181 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2029-2188 4e-86 283.4 In-house 125-301 (301) alignment
Range on Protein: 2029-2188
Range on HMM: 125-301/301.0
ECCHQYWKESGTADYGEYFVKIESSNEC-------------------NGYIERKIHIRSDKdgSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQ
..|.|||..| . .. ....... .||.                   |||||||....|||  |||||.|.||||||.||.|||| ||||||||||||||
skceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqq

KIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYAN
||||||||||||||||||||||||||.||||||||||||||||||.||.||||||||||||||||||||...|.|||||
kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2029-2180 3.2e-58 192.3 In-house 129-283 (305) alignment
Range on Protein: 2029-2180
Range on HMM: 129-283/305.0
ECCHQYWKESGTA--DYGEYFVKIESSNECNGYIERKIHIRS-DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVS
..|.||| || |   ..||. |...|... ..|||||..|   |.|  |  |.|.|.|||| .|..... ..|..|..| ..|.|  | |..||||..|.
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
|.||...|.||||..|.|.|||||.|.|..|......|.||.||....|..|   
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli

0050432 (Phosphotyrosine protein) phosphatases II 1978-2188 4.9e-53 175.8 In-house 57-307 (308) alignment
Range on Protein: 1978-2188
Range on HMM: 57-307/308.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILatnpnlDmCQREYINASYVDEC-----------------------------------------------
  ...|.. .|| ..||.|.|  || .|..|      |     |||||||| .                                               
lleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrek

CHQYWKES---GTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSRS
|.||| ..   |.  || ..|.. |  ....|. |.....  .|| |  | .|. |.|| .|.  .|  .|. .. | ...   .|||.|||||. |.|.
caqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRt

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYAN
|... . ..||| ..|| ||||.. | .|. .||.|.|.|||  .|... ...||. |..|
GtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkln

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2029-2186 5.3e-51 168.2 In-house 131-289 (290) alignment
Range on Protein: 2029-2186
Range on HMM: 131-289/290.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKD-GSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
. |.||| .|.|..|||. .|. . ...|.|||||.......  |..  |.|.|.| |. .| | .| |.|.||  ... | | | ...||||||||.||
vkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrs

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTY
.|.|.. .....|| |||.||||| |  |  ||| |.| .||  |....   ..  .||
avfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

0046845 (Phosphotyrosine protein) phosphatases II 1978-2188 6.5e-50 165.5 In-house 17-282 (284) alignment
Range on Protein: 1978-2188
Range on HMM: 17-282/284.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNlDMCQREYINASYVDEC-----------------------------------------------
. ...|.. .||   ||.|.| .||..|..| . .. |.   .|||||||| .                                               
llslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelveng

---CHQYWKESG-TADYGEYFVKIESSNECNGYIERKIHIRSDK-DGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQK-IGGGPVVVHCSDTV
   |.||| ..| .  ||...|.. | .....|. |.. ..  . .| |  |..|..|.|| .|.  .|  .|. ...| . ...  ||||.|||||. |
rekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGv

SRSGVYCSVSIALEQCKAEG---VVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYAN
.|.|... . ..||| ..||   .|||... | .|. .||.|.|||||  .|... ...||. |...
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle

0040438 (Phosphotyrosine protein) phosphatases II 1976-2186 8e-50 165.3 In-house 30-282 (317) alignment
Range on Protein: 1976-2186
Range on HMM: 30-282/317.0
GEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVDEC---------------------------------------------
    ...|.. .|| ..||...|  ||..|..|   ..       ||||||||                                               
lkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrek

CHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkiG-GGPVVVHCSDTVSRSGV
|.||| . .|  ||...|.. |  |..|.. |....  ..|. |  | .|. |.|| .|.   | ..|. .. | . ..  . ||||.||||. |.|.|.
caqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTY
.. . ..|||.. || |||... | .|. .||||.|.|||  .||.. ...| . |.
fiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl

0051299 (Phosphotyrosine protein) phosphatases II 1979-2180 8.7e-50 165.2 In-house 39-286 (288) alignment
Range on Protein: 1979-2180
Range on HMM: 39-286/288.0
KPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVD---------------------------------------------ECCHQ
 ...... .|| . ||...|  ||..|..| . ..  .    ||||||.|                                             | |.|
ltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaq

YWKESGTADYGEYFVKIESSNECNGYIERKIHIRSD----KDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGV
|| ..|.  ||...|.. |  ....|. |.....      .|| |  |..|..|.|| .|.   |  .|. . .|.. ..  ||||||||||. |.|.|.
Ywplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
.. . ..||| ..||.|||... | .|. .||.|.|.|||  .|... ...
fialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0036941 (Phosphotyrosine protein) phosphatases II 1979-2185 5.4e-48 159.2 In-house 29-282 (297) alignment
Range on Protein: 1979-2185
Range on HMM: 29-282/297.0
KPCTVGYSEENSPFNRFKNITVYDDNRIILatnpnlDMCQREYINASYVDEC---------------------------------------------CHQ
 ...|. ..|| . ||.|.|  ||..|..|      |     |||||||| .                                             |.|
gslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaq

YWKES--GTADYGEYFVKIESSNE--CNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSG
|| .   ..  ||...|.  | ..  ...|. |....   ..| |  | .|..|.|| .|.   | ..|. |. | ...... .||||.||||. |.|||
ywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsg

VYCSVSIALEQCK---AEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHST
... . ..|.| .    || ||.... | .|. .||||.|||||  .|... ...| . |
tfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

0047943 (Phosphotyrosine protein) phosphatases II 1978-2180 1.1e-47 158.2 In-house 27-272 (273) alignment
Range on Protein: 1978-2180
Range on HMM: 27-272/273.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILatnpnlDMCQREYINASYVDE---------------------------------------------CCH
. ...|.. .||  .||.|.|  ||..|..|      ..    ||||||||                                               |.
lltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekca

QYWKESG---TADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSG
||| ..|   .  ||...|.. | .....|. |.. ... ..| |  |..|..|.|| .|.   .  .|. |..| . .... ..||||||||. |.|.|
qYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtg

VYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
... . ..|.| ..|| |||... | .|. .||.|.|.|||  .|... ...
tfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2029-2189 1.6e-47 156.9 In-house 126-287 (287) alignment
Range on Protein: 2029-2189
Range on HMM: 126-287/287.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDK-DGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
| |.||| |. .  .||| ... . .  .||||||.... .. .|.   | |.|.|.|.  | | || |.| ||.. .. |.| | ...|||||||| ||
evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYANF
...|.. .....|| |||.||||| |  |  |||.| | |||. |.|.. .. .  .||..|
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf

0039614 (Phosphotyrosine protein) phosphatases II 1976-2183 2.2e-46 154.1 In-house 44-292 (297) alignment
Range on Protein: 1976-2183
Range on HMM: 44-292/297.0
GEEkPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDMcQREYINASYVDEC---------------------------------------------
  . ........|| ..||.|.|  ||..|..| .... |.    ||||||||                                               
lkp.dysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrk

CHQYWKESGTaDYGEYFVKIESSNECNGYIERKIHIRSdkDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGV
|.||| |.|.  ||...|.  .  ...||. |.....   .| |  | .||.|.|| .|.   . ..|.... | .....  .||||.||||. |.|.|.
caqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLH
..   ..|||.. || |||... | .|. .||||.|..||  .||.. ...| .
fiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0043336 (Phosphotyrosine protein) phosphatases II 1974-2180 4.2e-45 149.8 In-house 30-277 (278) alignment
Range on Protein: 1974-2180
Range on HMM: 30-277/278.0
KSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVDEC-------------------------------------------
 |    ........|| ..||.|.|  || .|..|   ..       ||||||||                                             
lsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgr

--CHQYWKeSGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSG
  |.|||  .|.  ||...|.  . .....|. |....   .|| |  | ... ..|| .|.   . ..|. . .|.....   .|||.||||. |.|.|
vkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTG

VYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
... . ..||| . || ||.... | .|. .||||.|..||  .|... ...
tfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 1978-2180 4.8e-45 150.0 In-house 44-304 (307) alignment
Range on Protein: 1978-2180
Range on HMM: 44-304/307.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLdMCQREYINASYV--------------------------------------------------
  ........|| ..||.|.|  ||..|..| . ..  .    |||||||                                                  
lgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelv

---DECCHQYWKESGTA-DYGEYFVKIESSNECNGYIERKIHIRSD-KDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCS
   .| |.||| ..|.   ||...|.  | ....||. |....    ..| |  |..|. |.|| .|.   . ..|. |. | . ...  .||||.||||
elgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

DTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
. |.|.|...   ..|.| ..||.   ||.... | .|. .||||...|||  .|... ...
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0040439 (Phosphotyrosine protein) phosphatases II 1980-2179 8.5e-45 148.7 In-house 2-245 (249) alignment
Range on Protein: 1980-2179
Range on HMM: 2-245/249.0
PCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDMCQreYINASYVD---------------------------------------------ECCHQY
...|.. .|| . ||...|  || .|..|   |.|  .   ||||||.|                                             | |.||
eysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSV
| ..|.  ||...|.  | .....|. |....   .||.|  | ..|.|||| .|.   . ..|. |. | . ....  ||||.||||. |.|.|...  
wplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

SIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMF
 ..||| . |. ||.... | .|. .||||...|||  .|... ..
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

0042113 (Phosphotyrosine protein) phosphatases II 1981-2179 7.6e-41 135.5 In-house 1-242 (245) alignment
Range on Protein: 1981-2179
Range on HMM: 1-242/245.0
CTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDMCQreYINASYVD---------------------------------------------ECCHQYW
..|.. .|| ..||...|  ||..|..|   ..   .   ||||||||                                             . |.|||
ysvallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

KESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSI
 ....  ||...|.  | . ...|. |....  ..|. |  ||... ..|| .|.   . ..|.... | . ... ..|||.||||. |.|.|... . .
plgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

ALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMF
.||| ..|. |..... | .|. .||||.|..||  .|... ..
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2030-2187 1.9e-40 134.0 In-house 140-297 (298) alignment
Range on Protein: 2030-2187
Range on HMM: 140-297/298.0
CCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
 .|.|| ..|.. |||  |.. |..|   .| ||... . |  ..  | |...| ||  |. ..  .||.....|   ||. |  ||.|.||. | ||| 
kyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYA
.. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  ...  ....
fiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_PTPRD_pd Subfamily PTPRD 2031-2185 3.8e-40 133.1 In-house 133-286 (564) alignment
Range on Protein: 2031-2185
Range on HMM: 133-286/564.0
CHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVY
||.|| |.||. |||. |..|...| . |. |.. ..  |. .|  | ||. |.||  |.  .. ..|..|..| . . . . ||.|||||  | |.|..
chkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtf

CSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHST
. ... ||. |.|..||..|. ||.|. ..  | | |||  |...|  . .  .|
ividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

0045098 (Phosphotyrosine protein) phosphatases II 1979-2181 4.3e-40 133.2 In-house 23-273 (278) alignment
Range on Protein: 1979-2181
Range on HMM: 23-273/278.0
KPCTVGYSEENSPFNRFKNITVYDDNRIIlatnpnldmcqrEYINASYV-------------------------------------------DECCHQYW
  .|..  ..| ..||.|.|  || .|..            .||||||.                                            | |.|||
seitpalylgnldknRykdilpydhsrVk............dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

KESGTADYGEYFVKIESSNECNGYIERKIHIRSD----KDGSSWDVIQFQVTDWPTDGIVREP--LTVLQVIDDVIHRQQK------------IGGGPVV
 |.|.  ||...|...|  ... |. |.....      .|. |. | ... . ||  |.  .|    .|.... . .....             .||||.
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSDTVSRSGVYCSVSIALEQCkaEGVVDVFQVTKAIRRTKPG-AVTTLEQYTSIYDVIDMFFK
||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..||||  .|... ....
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2031-2186 1.7e-38 127.5 In-house 131-286 (318) alignment
Range on Protein: 2031-2186
Range on HMM: 131-286/318.0
CHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVY
.|.|| ..|.  ||.  |..... |.. |. |..... ..  .| .| |...|.||  |.  .. ..|... .| . ||| | ||.|||||  | | ||.
vhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvf

CSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTY
. |.| ||. |||..|||||. | .|. ..  | | .||. ||||.  . .   |.
iavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2031-2186 4.5e-38 126.1 In-house 133-289 (319) alignment
Range on Protein: 2031-2186
Range on HMM: 133-289/319.0
CHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGS-SWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
...||.|    .||.. |..|. .| ..|| ||....  ..   . .| .|| |.|| ... .. ...|... .. . ..|   ||.|||||. | | | 
lkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTY
.. ....||. | |||.|||.. . .|  ..  | . |||. ||...  . .  .| 
fivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2028-2187 7.1e-38 125.2 In-house 90-249 (250) alignment
Range on Protein: 2028-2187
Range on HMM: 90-249/250.0
DECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
.. .||||   ..  ||.  |.. |..|   |. ||. . . |  ..  | |.. . ||  |. ..  .||.....|   ||..| .||.|.||  |.||
ektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrs

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHSTYA
| .. ..  ||. | | |||||.| |..|. .|.||..|||| ..| .|  . .  . ||
Gafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya

DSPc_SM00195 2030-2180 1.1e-34 115.4 In-house 110-262 (263) alignment
Range on Protein: 2030-2180
Range on HMM: 110-262/263.0
CCHQYWKES--GTADYGEYFVKIESSNECN-GYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSR
 |..||.|.  |. ..|.. ||. . ....  .| |..... ...  . .| |.|...||  |.  ..  ||...  | ......  ||.|||||. |.|
kcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
.|......|.|.....|  ||.|.. |..|  .||.|.|||||. ||..|  ..
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 2030-2180 1.1e-34 115.4 In-house 110-262 (263) alignment
Range on Protein: 2030-2180
Range on HMM: 110-262/263.0
CCHQYWKES--GTADYGEYFVKIESSNECN-GYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSR
 |..||.|.  |. ..|.. ||. . ....  .| |..... ...  . .| |.|...||  |.  ..  ||...  | ......  ||.|||||. |.|
kcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
.|......|.|.....|  ||.|.. |..|  .||.|.|||||. ||..|  ..
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0037934 (Phosphotyrosine protein) phosphatases II 1981-2179 2e-34 114.6 In-house 2-241 (243) alignment
Range on Protein: 1981-2179
Range on HMM: 2-241/243.0
CTVGYSEENSPFNRFKNITVYDDNRIILatnpnlDMcqREYINASYV----------------------------------------------DECCHQY
.... ..|| . ||...|  ||..|..|      .     ||||...                                               | |.||
fsiallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WKesGTADYGEYFVKIESSNECNGYIERKIHIRSDK-DGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSR
|   |.  ||...|.. |......|. |.....  . |. .. ||... . ||  |.  .|  .|. .|.|.  ...        .||||.||||  |.|
wp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

SGVYCSVSIALEQCkaeGvVDVFQVTKAIRRTKPG-AVTTLEQYTSIYDVIDMF
.|...   . |...   | ||.... | .|. .|| ||.|..||  .|... ..
tGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel

Y_phosphatase Protein-tyrosine phosphatase 2030-2176 5.2e-34 113.0 Pfam-A 83-233 (235) alignment
Range on Protein: 2030-2176
Range on HMM: 83-233/235.0
CCHQYWK--ESGTADYGEYFVKIE-SSN-ECNGYIERKIHIRSDKDGS-SWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQqKIGGGPVVVHCSDTV
 |.|||.  |...  ||...|... ... ....|. ||......|. | .  | |...|.||  |. ..|  .|..|..| ... .   ||||||||. |
kcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
.|.|......|.|||..||. |||.|. | .|. .||.|..||||  .|..|
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 2030-2176 5.2e-34 113.0 In-house 83-233 (235) alignment
Range on Protein: 2030-2176
Range on HMM: 83-233/235.0
CCHQYWK--ESGTADYGEYFVKIE-SSN-ECNGYIERKIHIRSDKDGS-SWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQqKIGGGPVVVHCSDTV
 |.|||.  |...  ||...|... ... ....|. ||......|. | .  | |...|.||  |. ..|  .|..|..| ... .   ||||||||. |
kcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
.|.|......|.|||..||. |||.|. | .|. .||.|..||||  .|..|
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

subfamily_PTPRA_pd Subfamily PTPRA 2029-2181 8.7e-34 111.9 In-house 141-296 (330) alignment
Range on Protein: 2029-2181
Range on HMM: 141-296/330.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDG----SSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGgPVVVHCSDTV
| |.||| . |.  ||.  |..| ..... |  ||. ..   |.    .|  | ||  | ||  |.  ||  .|...  | . .|. .| |.|||||  |
ekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
 |.| .. ..  ||. |||..||||.. | .|  .|  | |.|||. || |.  .. 
GrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2029-2177 1.8e-32 107.7 In-house 131-281 (297) alignment
Range on Protein: 2029-2177
Range on HMM: 131-281/297.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVR--EPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSR
. | .|| ..|.. .|.  |...| .|..|.|.|..... .|  .   | |.| ..||.. . |  .  ..|..|..| .  ..   ||..|||.  | |
kkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVID
 ||....   . . | |  ||.|.. | .|. .|  | | |||. .| .. 
tgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2029-2176 1.5e-30 101.1 In-house 115-262 (283) alignment
Range on Protein: 2029-2176
Range on HMM: 115-262/283.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSD-KDGSSWDVIQFQVTDWpTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
. | ||| . |. ||||. | ..     | .| ... .| .    |.  .  .|| || ..     ..  |  .. ||  |..   ||.||||| .. |.
ikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrt

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
.|....| .... ..| |||||.| | .|  ...|| ||.||  .....
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_Ptp69D_pd Subfamily Ptp69D 2029-2176 8.6e-29 95.6 In-house 131-282 (307) alignment
Range on Protein: 2029-2176
Range on HMM: 131-282/307.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGS-----SWDVIQFQVTDWPtDGIVRE-PLTVLQVIDDVIHrQQKIGGGPVVVHCSD
. |..|| .  .  ||.  ||. |..... ||.|....   |. |     |  |.|.. | |. | .| | . ..|..|. | .  .|   .|.||||| 
kkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvre.lyklnrsPivvhCsa

TVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
 |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  .
GvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2030-2179 1e-28 95.1 In-house 128-276 (315) alignment
Range on Protein: 2030-2179
Range on HMM: 128-276/315.0
CCHQYWKE--SGTADYGEYFVKIESSNECNGYIERKIHIRSDKDgsSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRS
 | ||| .  . ....|.. |.. | . . . . ||. .|  ..  |  | ||| |.||  |. ..  ..|..| .|    ..    ...||||  | |.
kcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrt

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMF
|| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||..   
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled

subfamily_PTPRK_pd Subfamily PTPRK 2031-2176 2.3e-28 93.9 In-house 128-273 (314) alignment
Range on Protein: 2031-2176
Range on HMM: 128-273/314.0
CHQYWKESGTAdYGEYFVKIESSNECNGYIERKIHIRS--DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSG
| .|| | ..  ||.  |.. ...  . .. |   ..    .      | ||| . ||. ..  .  ..|...  | . |.. . |..|||||    |.|
ClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtG

VYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
... ..| |.  . |||||||.. |..| .|.  | | |||. |||||
tfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_PTPRG_pd Subfamily PTPRG 2030-2176 5.4e-28 92.5 In-house 132-283 (563) alignment
Range on Protein: 2030-2176
Range on HMM: 132-283/563.0
CCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRS-----DKD-GSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDViHRQQKIGGGPVVVHCSDT
 |..|| . .. .||.  |......    | .|.. |.       |.  .   |.|.. |.||  |    .| ||. .     . .|   ||.|||||  
kcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
|.|.|.|. ..  |.| ..| .|.||.. | ||  ..  |.| |||. ..|..
vgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal

subfamily_PTPN6_pd Subfamily PTPN6 2029-2184 1.3e-27 91.6 In-house 138-301 (306) alignment
Range on Protein: 2029-2184
Range on HMM: 138-301/306.0
ECCHQYWKESG-TADYGEYFVKIESSNECNGYIERKIHIR-SDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIG---GGPVVVHCSDT
| | .|| ..  . .||.. |.  |... . || |....   .|.... .|.|.. ..||  |. ..| .||. ..|| ..|...     ||.|||||. 
ekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaG

VSRSGVYCSVSIALEQCKAEGV---VDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLHS
. | | .  . | |.. . .|.   .|. .. | .|. . | | | .||  .| .| .. . ..
iGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2030-2177 3.6e-27 89.6 In-house 126-273 (515) alignment
Range on Protein: 2030-2177
Range on HMM: 126-273/515.0
C-CHQYWKE--SGTADYGEYFVKIESSNECNGYIERKIHIRSDKDgsSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSR
  | .|| .  . .  .|.. |.. | . | | | ||...  ..|  |  | ||. |.||  |. ..  ..|..| .|   ....   |...|||  | |
ikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVID
 ||..|.   . . |   .||||.. . ||. .|  | | |||. ||... 
tGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2028-2176 1.1e-26 88.7 In-house 129-284 (325) alignment
Range on Protein: 2028-2176
Range on HMM: 129-284/325.0
DECCHQYWKES--GTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQK-----IGGGPVVVHC
.. | .|| .    .  .|   ||. . .|   |. |.....  |.| .  | |||.  |.  |  . | |.. ... | . ...      . .|..|||
kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

SDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
|. | |.||. |.  ||..   |  ||.|.. | .|. .|  | | .||. ||. .
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal

subfamily_CG7180_pd Subfamily CG7180 2030-2178 1.7e-25 84.3 In-house 125-288 (296) alignment
Range on Protein: 2030-2178
Range on HMM: 125-288/296.0
CCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSD-------K---DGSSWDVIQFQVTDWPTDGIV-REPLTVLQVIDDVIHRQQKI----GGG
 ...||.. . ..||| ||.| ....      |....          .   .     | .||.| |. .  |     ......  |   ..|.      |
mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDM
||||..|| .||||||... ..||. . |. ||||.  | .|| .|. | . |.|  ||||.  
PvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2029-2177 2e-25 84.4 In-house 130-276 (288) alignment
Range on Protein: 2029-2177
Range on HMM: 130-276/288.0
ECCHQYWKESGT-ADYGEYFVKIESSNECNGYIERKIHIRsdKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRS
. |..|| ....   ||.  |.. .|.| . ...||. .   |...  .. |.| . || .|. .    .|.... |   .|.   ||..||||. | |.
tkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrt

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVID
|.. ..  .... ..| ..||. . . .|. ..  | ||.||  ||.|. 
gtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2029-2175 5.1e-25 83.4 In-house 138-286 (319) alignment
Range on Protein: 2029-2175
Range on HMM: 138-286/319.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRS-DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSR
. | |||   .   .... ||..| .|.. |. |.|..    |     .. ||    ||  |    |  ...... | | ..|  .  ..|||||  | |
dkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDV
.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
tGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1970-2176 5.3e-25 82.6 In-house 26-232 (392) alignment
Range on Protein: 1970-2176
Range on HMM: 26-232/392.0
THSLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVDE--CCHQYWKES--GTADYGEYFVKIESSNECNGYIERKIH
 | | . .  | ||.  | | . ||.|||  || .|..|      |. ...|.||||..   . . |       .|   ...  .   | .   .  |..
fhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid..dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklk

iRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTT
   ||  .   | ||..|.|| ... .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   ||| .|  | |
.egdkgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqt

LEQYTSIYDVI
 |||. ||  .
keqyafiygav

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2029-2176 7.1e-25 83.1 In-house 102-251 (284) alignment
Range on Protein: 2029-2176
Range on HMM: 102-251/284.0
ECCHQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRS-DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSR
. | |||   .   .... ||..| .|.. |. |.|..    |     .. ||    ||  |    |  ...... | | ..|  .  ..|||||  | |
dkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

SGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  .
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2030-2181 1.3e-24 81.7 In-house 114-269 (274) alignment
Range on Protein: 2030-2181
Range on HMM: 114-269/274.0
CCHQYWKESGTA----DYGEYFVKIESSNECNGYIERKIHIRSDKDgsSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI--GGGPVVVHCSDT
 |..|. ..  .     ||.  .|.|. .|.|.|  ||. ... ..  . .|. .  ||||     ... |.|.....| . ...     .|||||||  
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
. | |.. ..|||. | ..|.||||....  .|  . | | | |||  |. .. .. |
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2030-2179 1.4e-24 81.6 In-house 133-279 (315) alignment
Range on Protein: 2030-2179
Range on HMM: 133-279/315.0
CCHQYWKESgTADYGEYFVKIESSNECNGYIERKIHIRSDKdgSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGV
 . .|| .     ||.. |   | .  . |  | . . ...     .|.|...| ||. |. .  ......|  |   ...   |..|||||. | |.| 
kaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI-DMF
.....  |.| .|| ..||... . .|. . ..| ..|||  |||.. . |
fitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2031-2177 4.5e-24 80.0 In-house 126-273 (281) alignment
Range on Protein: 2031-2177
Range on HMM: 126-273/281.0
CHQYWKESG-TADYGEYFVKIESSNECNGYIERKIHIrSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
||.|| .   .  ||.. || ....| . |||||... . ..| . .| |.. | ||  |.  ..  .|.  ..| . ..|    |.|.|||  | |.|.
ChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGt

YCSVSIALEQCKAE-GVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVID
| ..  ......||   .|| .| . .|...   | |. ||. .| .. 
yialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavl

subfamily_PTPRB_pd Subfamily PTPRB 2031-2179 4.5e-24 80.0 In-house 136-284 (293) alignment
Range on Protein: 2031-2179
Range on HMM: 136-284/293.0
CHQYWKES-GTADYGEYFVKIESSNECNGYIERKIHIRSdkDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRSG
|..|| .   .  ||.  |.. ...| . .. |...|.   . .. .| |.. | ||  |.  .. |.|. .  | ... ..   .|.|||||  | |.|
CeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtG

VYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMF
.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .
tfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl

PTPc_DSPc_SM00012 2077-2176 1.5e-23 78.3 In-house 2-103 (105) alignment
Range on Protein: 2077-2176
Range on HMM: 2-103/105.0
VIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKAIRRTKPGAVTTLEQYTSIYD
| ....|.||  |. .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..|.|.|...| . ||.||. |..|. .||.|.|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al

subfamily_PTPN3_pd Subfamily PTPN3 2031-2176 1.6e-23 78.0 In-house 126-271 (280) alignment
Range on Protein: 2031-2176
Range on HMM: 126-271/280.0
CHQYWKES-GTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGV
||||| |.  . .|||. ||.|...| . |. |.. ..  .   .  ..|.| ..||  |.  ..  .|.... | .....    |||||||  . |.||
ChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGv

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
.  . .||    |.  | . .. . .|  .   | | .||. . . |
lilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai

subfamily_PTPN12_pd Subfamily PTPN12 2031-2181 2.1e-23 77.6 In-house 125-278 (290) alignment
Range on Protein: 2031-2181
Range on HMM: 125-278/290.0
CHQYWKESGTAD--YGEYFVKIESSNECN-GYIERKIHIRSDkdGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRS
|..|| |.|  .  .||. |. |. . .. ... | .... .  . |  | ||. |.||  |. . . ..|..|..| ..|.     |.|||||  | | 
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrt

GVYCSVSIALEQCKAEGV---VDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
|. ... .. |. ||| .   .|||..   .|. .. .| | |||. .|  .  ...
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2030-2181 1.4e-22 75.0 In-house 105-265 (270) alignment
Range on Protein: 2030-2181
Range on HMM: 105-265/270.0
CCHQYWKESGTA--DY--GEYFVKIESSNECNGYIERKIHIRsdKDGSSWDVIQFQVTDWPTDGIVREPL------TVLQVIDDV-IHRQQKIGGGPVVV
 | .|| ..     ..  |.  |  .|..  .||| ......  ..|..  .. |. ..|| .|..||.        .|... .|  .....  ..|..|
kCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

HCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
|||. | |.|.   . ||..  . .. ||| .. ...|. ..  | . |||. .| .. .. .
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1970-2030 1.5e-22 74.7 In-house 21-81 (301) alignment
Range on Protein: 1970-2030
Range on HMM: 21-81/301.0
THSLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDMCQREYINASYVDEC
 ..||.||.|.||||.||||...||||||||||||||||...||||.||||||||||.|..
ykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgy

subfamily_PTPN13_pd Subfamily PTPN13 2031-2176 5.2e-21 70.1 In-house 119-265 (273) alignment
Range on Protein: 2031-2176
Range on HMM: 119-265/273.0
CHQYWKESGT---ADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRS
||.|| ||       .. . |. .  .. .|.  |.....  . | | .| ... ..||  |. .... .||..  | . |.    ||.|||||  . ||
chrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrs

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
|.. .. ..|.  . .  .|| .. . .|. . | | | .||  .| .|
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_PTPN23_pd Subfamily PTPN23 2029-2176 5.4e-21 69.7 In-house 123-276 (288) alignment
Range on Protein: 2029-2176
Range on HMM: 123-276/288.0
ECCHQYWKE--SGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIH---RQQKIGGGPVVVHCSDT
. ...|| |    |  .|.. | ..| .| . ..||.....  .     .|   |.| ||  |.   | |.||..| | .    .|.    |.|||||  
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaG

VSRSGVYCSVSIALEQC-KAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
| |.||.. |  |...  | .|..|. || . .|. .   | . ||.   |...
vgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav

subfamily_PTPN9_pd Subfamily PTPN9 2031-2176 5.6e-21 69.8 In-house 127-286 (297) alignment
Range on Protein: 2031-2176
Range on HMM: 127-286/297.0
CHQYWK--ESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQ------------KIGGGPV
| |||.  |  .|..|.. |.  . .| . | .|...|.  |.. |  |. ||.. ||  |. ..  ..|.|.. | ..|             .. | |.
cgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPi

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
|||||  . |.| .... |.|.. . .|.|||... | .|  .  .. | |||.  |  .
vvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav

0051429 (Phosphotyrosine protein) phosphatases II 2021-2181 5.9e-21 70.8 In-house 6-226 (272) alignment
Range on Protein: 2021-2181
Range on HMM: 6-226/272.0
YINASYVD-----------------------------------------------ECCHQYWK------------ESGTADYGEYFVKIESSNECNGYIE
||||..|.                                               . |..||             .  |  || ..|.. |   .. || 
yiNardvggygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyil

RKIHIRSD-KDGSSWDVIQFQVTDWPTDGIVREPltVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVD--------VFQVT
|.. ..   . | .  | ... ||||..|. .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||        .... 
rellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeav

KAIRRTKPGAVTTLEQYTSIYDVIDMFFK
. .|.  |||| | |||  .|...  ...
eelraqrpgavqteeqylflyeallellr

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2029-2176 2.2e-20 67.9 In-house 85-235 (237) alignment
Range on Protein: 2029-2176
Range on HMM: 85-235/237.0
ECCHQYWKESG-TADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVI-QFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVS
. ||.|| ..   | || . | .   .|   |  | . .          .| |.| | ||  |. ..  ..|.   ..|.| ...   || ..|||  | 
lkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
|.|..  .   | |.| . |||...  ..|   .|  . | .||  |...|
rtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2030-2173 2.4e-19 64.5 In-house 93-234 (239) alignment
Range on Protein: 2030-2173
Range on HMM: 93-234/239.0
CCHQYWKESgTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGV
 ||||| .| |. | .  | .  ..    || | . .    .     | |...| ||  |. .   .|| .    | ..   |  | |.|||  | |.| 
kchqywpds.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIY
.  .   | |.| .  ||.|.  ||||  .|  | | |||  |.
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2030-2173 2.5e-19 64.4 In-house 92-233 (239) alignment
Range on Protein: 2030-2173
Range on HMM: 92-233/239.0
CCHQYWKESgTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGV
 ||||| .| |. | .  | .  ..    || | . .    .     | |...| ||  |. .   .|| .    | ..   |  | |.|||  | |.| 
kchqywpds.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIY
.  .   | |.| .  ||.|.  ||||  .|  | | |||  |.
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih

0036282 (Phosphotyrosine protein) phosphatases II 2029-2174 1.3e-18 62.7 In-house 52-164 (174) alignment
Range on Protein: 2029-2174
Range on HMM: 52-164/174.0
ECCHQYWKEsgtadygeyfvkiessnecngyierkihirsDKDGSSWDVIQFQVTDWPTDGIVREPLtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
. |..|| |                               ...  .  .||.. . || .|    .  .|.... | . ... .||||.||||  |.|.|
ykcinywpe...............................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtG

VYCSVSIALEQCKaEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYD
. .   . | . . |..||.... ...|. .||.|.| .||  .|.
tlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy

0041856 (Phosphotyrosine protein) phosphatases II 1989-2181 1.5e-18 62.5 In-house 1-172 (182) alignment
Range on Protein: 1989-2181
Range on HMM: 1-172/182.0
NSPFNRFKNITVYDDNRIILATNPNLDMCQREY-----------------------------INASyvdecCHQYWKesgtadygeyfvkiessnecngy
| . ||...|  || .| .   |.|| .. .                               .|..     ...||                        
nldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp.......................

ierkihirsdkDGSSWDVIQFQVTDWPTDGIVRePLTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGvVDVFQVTKAIRRTK
           .     .||.. . || .|.   . ..|. |..|..      ||||.||||  |.|.|...   . ...    | |..... | .|. .
...........ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrR

PGAVTTLEQYTSIYDVIDMFFK
||.|.|..||  ..... ....
pgmvitpnqyfflqlallelll

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2032-2176 3e-18 60.5 In-house 129-275 (439) alignment
Range on Protein: 2032-2176
Range on HMM: 129-275/439.0
HQYWKESGTADYGEYFVKIESSNECNGYIERKIHIRSDKDGS--SWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
..||  .. . ||.  |...   |   |. | ...  ..| .     |.||. . ||   .  .   ||. .  .   ..|   ||||||||  | |.| 
ykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
  .. ||||| |.|  ||.  . | .|. .   | .| ||  ||. .
iialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav

subfamily_PTPN14_pd Subfamily PTPN14 2030-2181 9.6e-18 59.2 In-house 134-297 (300) alignment
Range on Protein: 2030-2181
Range on HMM: 134-297/300.0
CCHQYWKES----GTADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTV---LQVIDDVIHRQQKIG-----GGPVV
 ...|. ..     |...|.. |  . |.. . .| ......    .   .|. .| |||| .|. ... .    |. .. | .. ..         ||.
ksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.|.  ..|
vhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

0049772 (Phosphotyrosine protein) phosphatases II 1968-2181 1.1e-17 60.3 In-house 25-281 (314) alignment
Range on Protein: 1968-2181
Range on HMM: 25-281/314.0
LNTHSLKSGEEKPCTVGYSEENSPFNRFKNITVYDdNRIILatnPNLDMCQREYINASYVDECcHQY------------------------WKES-----
||..||    |. ..|.. ..|   ||...|  .| || ||   |.|..    |||||||| .  ..                        |. .     
lnrrslsvlpeltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdl

--------------------------------------GTADYGEYFVkiessnecngyierkiHIRSDKDGSSWDVIQFQVTDWPTdGIV---REPLTV
                                       || . |..                  .  |..  .  .|..  ...|  | .   .  . .
nvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk................eelydpelferlgikylripvpD.gsaplledfdef

LQVIDDVihrqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaeGVvDVFQVTKAIRRTKP-----GAVTTLEQYTSIYDVIDMFFK
|..|...        ||||.|||.. ..|.|... . . . ..   || .. .. . .|.. |     |.. .||||  |.... ...|
lefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk

0043147 (Phosphotyrosine protein) phosphatases II 2020-2174 3.7e-15 51.5 In-house 6-155 (172) alignment
Range on Protein: 2020-2174
Range on HMM: 6-155/172.0
EYINASYVDEC-------CHQYWKESGTADYGEYFVKIESSNecngyIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVrEPLTVLQVIDDVIHRQQKIG
 ||||||.| .       ..|.   . .||. ... .   .      | .      |... .  .||.. . ||  |    .  .|.... . .....  
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgith.....ivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalsp

GGPVVVHCSDTVSRSGVYCSVSIALeqckaeG-VvDVFQVTKAIRRTKPGAVTTLEQYTSIYD
||||.||||  |.|.|. .   . |        . ..... . .|. .||||.. .||  .|.
ggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyy

subfamily_PTPRN_pd Subfamily PTPRN 2030-2174 5e-15 50.0 In-house 141-286 (297) alignment
Range on Protein: 2030-2174
Range on HMM: 141-286/297.0
CCHQYWKESGTADYGEYFVKIESSN-ECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRSG
 |..|| . |.. |. | |.. |    |. |. | ....  .   .  | ||    ||  |.  .. ..|.    |  .  .    |.|||||| . |.|
qckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtG

VYCSVSIALEQC-KAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYD
||. . . |..  |    .|.    . .|  .|| | | .|.  .. 
vyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt

0051082 (Phosphotyrosine protein) phosphatases II 2021-2175 6.6e-15 50.5 In-house 5-148 (151) alignment
Range on Protein: 2021-2175
Range on HMM: 5-148/151.0
YINASYVDE----------------------------------CCHQYWKESGtadygeyfvkiessnecngyierkihirsdkdgssWDVIQFQVTDWP
|||.|||..                                   |..|..| |                                    .|......|||
yinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg...................................ievlhipildwp

TDGIVREPLTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaegvVDVFQVTKAIRRTKPGAVTTLEQYTSIYDV
. |.   . .||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
dpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2076-2175 7.1e-15 49.2 In-house 90-189 (440) alignment
Range on Protein: 2076-2175
Range on HMM: 90-189/440.0
DVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDV
 . |..   ||  |. .    ||..|.|| . |.| | ||..||||  ..|.||  .|   | ..|    .|.| . ...|  .|  | | |||. ....
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea





subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2070-2175 9.3e-15 49.3 In-house 151-254 (267) alignment
Range on Protein: 2070-2175
Range on HMM: 151-254/267.0
KDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIddVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQY
|. |. .|  .    |  .   .  |  |  |  . . | . |. |.||.||| | ||| .  .   ||. | |||.|.|.  . ||  ..| | |.|.|
knesahnvtlyyykkwnintnnkpylkplfgi..laknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkery

TSIYDV
  |...
iyihel

subfamily_PTPN1_pd Subfamily PTPN1 2031-2173 5.3e-14 46.6 In-house 113-264 (290) alignment
Range on Protein: 2031-2173
Range on HMM: 113-264/290.0
CHQYWKESGT-----ADYGEYFVKIESSNECNGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQ-KIGGGPVVVHCSDTV
|.||| .         .  .. ||. | .. . |. |....   |   . ....|  | ||  |. . | . |. . .| .    .   ||.|.|||  .
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

SRSGVYCSVSIALEQCKAEGV---VDVFQVTKAIRRTKPGAVTTLEQYTSIY
 ||| .| |   | . ....    ||. .|  ..|. . | . | .|    |
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy

0048076 (Phosphotyrosine protein) phosphatases II 2059-2178 1.5e-13 46.2 In-house 29-141 (145) alignment
Range on Protein: 2059-2178
Range on HMM: 29-141/145.0
YIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiALEQCKAEGvVDVFQVTKAIRRT
 | . . . |.... .  .||.. ..||  |.   . ..|.... . . ...  ||||.||||  |.|.|...    |.  .. .| |..... . .|. 
gittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsq

KPGAVTTLEQYTSIYDVIDM
 ||||.. .|.  .|... .
rpgavpnpgqlrflyefele

0049260 (Phosphotyrosine protein) phosphatases II 2027-2174 2.2e-13 45.6 In-house 47-144 (152) alignment
Range on Protein: 2027-2174
Range on HMM: 47-144/152.0
VDECCHQYWkesgtadygeyfvkiessnecngyierkihirsdkdgsswdviQFQVTDWPTDGiVREPLTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSR
  ..|.||.                                           |.. . || .| | .   .|. . ..|.. ..  ||||.||||  |.|
gklkceqyi...........................................qylhlpwpDhg.vpdlsqlllflllfieklaldkggpvlVHCsaGvgR

SGVYCSVSIALeqckaeGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYD
.|...   . |        |..... . .|. .||||.. .|.  .|.
tgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

0046846 (Phosphotyrosine protein) phosphatases II 2031-2180 3.4e-13 45.2 In-house 65-173 (176) alignment
Range on Protein: 2031-2180
Range on HMM: 65-173/176.0
CHQYWKESGTADYgeyfvkiessnecngyierkihirsdkdgsswdviQFQVTDWPTDGIVREpLTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVY
|..||.|  ....                                   |.....||  |.      .|.... .  ....  ||||.||||  ..|.|..
cpnywpeleklgi...................................qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtl

CSVSialeQCKAEGVVDVFQVTKAIRRTKP-GAVTTLEQYTSIYDVIDMFF
.        .. |  ..|... . .|. .| |||.| |||  .|... ...
vaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2031-2176 5.7e-13 43.2 In-house 136-279 (290) alignment
Range on Protein: 2031-2176
Range on HMM: 136-279/290.0
CHQYWKES--GTADYGEYFVKIESSNEC-NGYIERKIHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVihRQQkigGGPVVVHCSDTVSRS
|.||. |    .  .||. |    ...  .  | . . .|  ..| .  .  ...  ||   .    |..|...  .  |.     ||||||||  . |.
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrt

GVYCSVSIALeQCKAEG-VVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
| . .. ..| |.  .|  .|. .. .|.|... ..|    ||  . ...
Gtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil

fn3 Fibronectin type III domain 1383-1457 6.5e-13 41.8 Pfam-A 2-79 (85) alignment
Range on Protein: 1383-1457
Range on HMM: 2-79/85.0
APSSFTVVSKTATTINVSWTALD--SSDADGYVVNVTSDTDTV--QTVQVKGSnTNAITLNGLRELTTYNITVRAYQQL
||. ..| . |.|....||.. .  ... .|| | . .....   ....|... |.  ||.||.. |.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprt.ttsvtltgLkpgteYefrVqavnga

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2016-2180 1.1e-12 42.7 In-house 98-259 (290) alignment
Range on Protein: 2016-2180
Range on HMM: 98-259/290.0
MCQREYINASYVDECCHQYWKESG--TADYGEYFVKIESSNECNGYIERKIHIRSDkDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQqkigg
.|..|  .|   .. | .| .||      ..   ||  |  . .. ..|.. .. | |.  . |   .. .| .  . ....|.|..|. |  ..     
lcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvkask.....

GPVVVHCSDTVSRSGVYCSVSIALEQCK-AEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFF
 ||.||| | .||| .  .. ..       .| | . .| ||.|. .  |.|. .... .  .| . .
tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivlla

0044763 (Phosphotyrosine protein) phosphatases II 2015-2181 2e-12 42.6 In-house 14-172 (178) alignment
Range on Protein: 2015-2181
Range on HMM: 14-172/178.0
DMCQREYINASYVDEC------------------------------------CHQYWKESGTadygeyfvkiessnecngyierkihirsdkdgssWDVI
...  .|||||....                                     |..|| |.                                    . ..
glersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeag..................................iqyl

QFQVTDWPTDGIVREPLTVLQVIDDVIhrqqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGVvDVFQVTKAIRRTKPgAVTTLEQYTSIYDVIDM
.. . |...  . .  | ... |....    .  ||||.||||  |.|||. .   . ...    |. ..... . .|. .| .|.. .|.  .|..  .
hipipDhgvpdllehflefvefieeal....dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr

FFK
..|
llk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1973-2029 2.1e-12 41.5 In-house 29-86 (290) alignment
Range on Protein: 1973-2029
Range on HMM: 29-86/290.0
LKSGE-EKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDMCQREYINASYVDE
|.||| |.  ||| ...|.. |||.|| |||||||.|   ..   |. |||||.|...
ldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikg

subfamily_CG42327_pd Subfamily CG42327 2112-2181 2.2e-12 41.3 In-house 246-316 (319) alignment
Range on Protein: 2112-2181
Range on HMM: 246-316/319.0
GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
  ||.|||||| | |.|.  .  ||... .     ||. |.   .|| .  || | |||  || |. .. |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

0048179 (Phosphotyrosine protein) phosphatases II 2064-2174 3.9e-12 41.6 In-house 48-139 (144) alignment
Range on Protein: 2064-2174
Range on HMM: 48-139/144.0
IhirsdkdgsswdVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIALeqckAEGvVDVFQVTKAIRRTKPGAV
             .||.. ..||  |.   .  .|.... . . ..   ||||.||||  |.|.|...   . .     .| ...... . .|.  ||||
e............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgav

TTLEQYTSIYD
.. .|.  ...
pnpgqlrfLle

fn3 Fibronectin type III domain 259-332 7.7e-12 38.4 Pfam-A 3-79 (85) alignment
Range on Protein: 259-332
Range on HMM: 3-79/85.0
PSSLTEVSKTATTITVSWTALD--SSDADGYVVNVTSNTDT--VQTVQVEGSSNnTITLNGLRGGTTYSITVRAYQQL
|. |.  . |.|..|.||.. .  ... .|| | . . ...   ....|..... . ||.||. ||.|...|.|. . 
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2034-2175 8.6e-11 36.4 In-house 50-199 (199) alignment
Range on Protein: 2034-2175
Range on HMM: 50-199/199.0
YW--KESGTADYGEYFVKIESSNECNGYIERKIHIRS--DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRS
||   ||||. ||   |  ..      |    . . .      |. .. ..| | |         | |  |.   .| .. ..    ||.|||||    .
ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgft

GVYCSVSIALE---QCKaEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDV
||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
gvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2034-2175 8.6e-11 36.4 In-house 49-198 (198) alignment
Range on Protein: 2034-2175
Range on HMM: 49-198/198.0
YW--KESGTADYGEYFVKIESSNECNGYIERKIHIRS--DKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRS
||   ||||. ||   |  ..      |    . . .      |. .. ..| | |         | |  |.   .| .. ..    ||.|||||    .
ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgft

GVYCSVSIALE---QCKaEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDV
||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
gvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv

fn3 Fibronectin type III domain 580-654 1.2e-10 34.5 Pfam-A 2-79 (85) alignment
Range on Protein: 580-654
Range on HMM: 2-79/85.0
APSSLTDINNTATTITVSWTALD--SSHANGYVVNVTSDTGT--VQTVQVEGNSNnTITLNGLRGEIIYSITVRAYQQL
||. |. ...|.|..|.||.. .  ...  || | . ...|.   ....|..... . ||.||.    |...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2031-2183 1.2e-10 35.7 In-house 122-280 (287) alignment
Range on Protein: 2031-2183
Range on HMM: 122-280/287.0
CHQYWKESGT-ADYGEYFVK-IESSNECNGYIERKIHIRsDKDGSS-WDVIQFQVTDWPTDGIVREPLTVLQVIDDV----IHRQQKIGGGPVVVHCSDT
|..|| |       | | |  .. ..    |  | . .  | ..     | |... .|| ...    . ... . ||      ...  . ||.|||..  
cykywPerevPmrvGGysvvlldydikePeygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKLH
. |||.. .. . ... .  | ||| .|   .|  . . | .  |.  .|. .  ..|  
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1972-2028 3.5e-10 34.5 In-house 30-83 (305) alignment
Range on Protein: 1972-2028
Range on HMM: 30-83/305.0
SLKSGeEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVD
|| .  |... || .|.|   ||.|.||..||.||||.....||  ...||||||||
slyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvd

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2067-2187 7.6e-10 33.3 In-house 168-286 (307) alignment
Range on Protein: 2067-2187
Range on HMM: 168-286/307.0
RSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIALEQ-CKAEGVVDVFQVTKAIRRTKPGAVTT
. |  . |  . ..| ..||  |. .  || . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |
kvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqt

LEQYTSIYDVID-MFFKLH-STYA
  ||  .. |.   |..|.  ||.
eaqylylhrvlleyflelyketye

fn3 Fibronectin type III domain 935-999 2e-09 30.6 Pfam-A 18-85 (85) alignment
Range on Protein: 935-999
Range on HMM: 18-85/85.0
LTWNEVNcsERNGLITGYTVMISNS-----GVTYNLTSTERYIILNDLVFGTEYNISVAAVNSAGRGPFS
|.|.. .  ...| ||||.|  ...      .......|..  .|..|  ||||...|.||| || ||.|
lsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 1667-1731 5.6e-09 29.2 Pfam-A 18-85 (85) alignment
Range on Protein: 1667-1731
Range on HMM: 18-85/85.0
LTWNEVNcsKHDGLITGYTVMISNS-----SITYNLTSTERYIILNDLAFGTKYNISVAAVNSAGRGPFS
|.|.. .  . .| ||||.|  ...     . ......|..  .|..|  ||.|...|.||| || ||.|
lsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_PTPRD_pd Subfamily PTPRD 1972-2028 1.2e-08 29.1 In-house 31-85 (564) alignment
Range on Protein: 1972-2028
Range on HMM: 31-85/564.0
SLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLdmCQREYINASYVD
....|.. ....   ..| . ||..||. || .|..| . ..    . .|||||..|
kieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfid

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2074-2172 2.4e-08 27.8 In-house 189-280 (302) alignment
Range on Protein: 2074-2172
Range on HMM: 189-280/302.0
SWDVIQFqvTDWPTDGIVREPLTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSI
. |...|  . ||  |  .|. | |...      ...     |.||||  | |.|   ..   .. |. . | |. .. . .|. . ||| . .| . .
tvdilaf..sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1978-2028 3e-08 28.0 In-house 36-80 (287) alignment
Range on Protein: 1978-2028
Range on HMM: 36-80/287.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILAtnpnldMCQREYINASYVD
|.  |.. ...| . ||...| |.|..|..|        .. .||||...|
edevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfid

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2071-2181 3.8e-08 27.4 In-house 182-288 (305) alignment
Range on Protein: 2071-2181
Range on HMM: 182-288/305.0
DGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVV-DVFQVTKAIRRTKPGAVTTLEQY
 ...  | ..   |||  |.    |..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  .. . ||  .  .. | .||
gekarkvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqy

TSIYDVIDMFFK
  ...||  .|.
lfvhqvilnyfr

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1974-2030 4.7e-08 27.1 In-house 33-84 (95) alignment
Range on Protein: 1974-2030
Range on HMM: 33-84/95.0
KSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDmcqreYINASYVDEC
      | ||| || | | ||| ||  ||  |..|.|. . |     |||| .||  
smtsgapytvgsseanipknrflnifpydatrvvlttkrdsd.....yinacfvdgy

fn3 Fibronectin type III domain 1748-1839 6.6e-08 25.8 Pfam-A 8-84 (85) alignment
Range on Protein: 1748-1839
Range on HMM: 8-84/85.0
VSSIvDTTWAVISWSKPIyiPSDYPIITYEIGYHALESGNcsmayddditpeILNLSNVSSNDTFTIITGLNSNTCYIFGIRAYSDNGYGAW
||..  .| ...|||.|   . . ||  ||. |   ..|.              .  .|... |  ..|||. .| | | ..|....|.| .
vsev.tstsltlsWsppk..dgggpitgYeveyrekggge............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

fn3 Fibronectin type III domain 1016-1108 8.1e-08 25.5 Pfam-A 8-85 (85) alignment
Range on Protein: 1016-1108
Range on HMM: 8-85/85.0
ASSImDTTWAIISWSVPSyiPSDYPIITYEIGYHALESGNcsmvydddinpqVLNLFNVSSNDTFTTITGLNSNTCYIFGIRPYSDNGYGEWT
.|..  .| . .||| |.  . . ||  ||. |   ..|.            . . |.|... |  |.|||. .| | | .. ....|.|...
vsev.tstsltlsWsppk..dgggpitgYeveyrekggge............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2115-2176 9.3e-08 26.3 In-house 230-291 (297) alignment
Range on Protein: 2115-2176
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||||.. .||..
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2083-2185 9.5e-08 25.8 In-house 189-290 (302) alignment
Range on Protein: 2083-2185
Range on HMM: 189-290/302.0
TDWPTDGIVREPLTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFKL
| |. . .  .  .. . . .| . ..  .  ..|.     . | |.  .. .|.|. ...  . . .. |.||  .| || .|.||.|.| .. ...| 
tnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk

HST
. |
kvt

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2077-2177 1.1e-07 25.9 In-house 169-266 (281) alignment
Range on Protein: 2077-2177
Range on HMM: 169-266/281.0
VIQFQVTDWPTDGIVREPLTVLQviddvIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKAIRRTK-PGAVTTLEQYTSIYD
. ..   .||   .      .|.     | |. .    | |.|||  | |||   .| |||.  ..   . |. |.   .| |    .| ||.||  |. 
ithwlwkewpdwqvpessevmlk.....ilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwk

VID
|. 
vll

DSPc_SM00195 1972-2028 2e-07 26.0 In-house 9-63 (263) alignment
Range on Protein: 1972-2028
Range on HMM: 9-63/263.0
SLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLdmCQREYINASYVD
...| ..|..| .  ..|.  ||.||| .||..|..| ....    . .||||.|..
leestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyik

PTPc_SM00194 1972-2028 2e-07 26.0 In-house 9-63 (263) alignment
Range on Protein: 1972-2028
Range on HMM: 9-63/263.0
SLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLdmCQREYINASYVD
...| ..|..| .  ..|.  ||.||| .||..|..| ....    . .||||.|..
leestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyik

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2117-2177 2.6e-07 24.9 In-house 2-62 (69) alignment
Range on Protein: 2117-2177
Range on HMM: 2-62/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVID
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| . 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1974-2028 4.5e-07 24.3 In-house 25-78 (281) alignment
Range on Protein: 1974-2028
Range on HMM: 25-78/281.0
KS-GEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVD
.. | ... |  ...||   ||..||. ||  |. .. | .    . .||||..|.
aaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvp

subfamily_PTPN6_pd Subfamily PTPN6 1983-2028 5.6e-07 23.9 In-house 48-90 (306) alignment
Range on Protein: 1983-2028
Range on HMM: 48-90/306.0
VGYSEENSPFNRFKNITVYDDNRIILAtnpNLDMCQREYINASYVD
 |   ||   ||.|||  .|..|.||.   . .. . .||||.|..
egakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyik

subfamily_ptpA1_pd Subfamily ptpA1 2060-2138 6.4e-07 23.4 In-house 173-254 (418) alignment
Range on Protein: 2060-2138
Range on HMM: 173-254/418.0
IERkiHIRSDKDGSSWDVIQFQVTDWPTDGIVREPLTVLQVIDDVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIALE
| |   ||   .| . |. |.|   ||   |      . |..  .  ||..|        |..||||  | |.| .|.  | ..
itr..nirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2117-2181 8.9e-07 23.2 In-house 1-65 (69) alignment
Range on Protein: 2117-2181
Range on HMM: 1-65/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| .   .|
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk

fn3 Fibronectin type III domain 776-835 1.1e-06 21.9 Pfam-A 11-78 (85) alignment
Range on Protein: 776-835
Range on HMM: 11-78/85.0
LNATSIKVNWTNS----SEANGYVIEYTTGGVT--RNVLSTSEDE--IVLTNLSSMSTYTISVYSYTD
 ..||. ..|. .    ..  || .|| . | .   .  ......   .||.|   ..|...|.....
vtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavng

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1976-2028 1.1e-06 22.9 In-house 35-85 (319) alignment
Range on Protein: 1976-2028
Range on HMM: 35-85/319.0
GEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVD
....  .    |||.. ||..||  ||  |..|.. ..  . . .|||||..|
avndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfid

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2077-2176 1.3e-06 22.7 In-house 173-267 (288) alignment
Range on Protein: 2077-2176
Range on HMM: 173-267/288.0
VIQFQVTDWPTDGIVREPLTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVI
| .  . .|. ||.  . |. |.... . .  ||    |.|||.|  | |.|    . ||||. . .  . . .. .  |  .  |..|  ||  .. ..
vkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv





subfamily_Ptp69D_pd Subfamily Ptp69D 1978-2028 1.5e-06 22.5 In-house 37-85 (307) alignment
Range on Protein: 1978-2028
Range on HMM: 37-85/307.0
EKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVD
.| ..|.  .||   ||...|. .|..|..|.. .  .  . .|||||.. 
dkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfik

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2075-2180 1.8e-06 21.8 In-house 188-289 (305) alignment
Range on Protein: 2075-2180
Range on HMM: 188-289/305.0
WDVIQFQVTDWPTDGIVREPLTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIALEQCKA-EGVVDVFQVTKAIRRTKPGAVTTLEQYTSIY
  | ..| |.||  |.    || |...  .  |  |.   |.|||||  . |.|   ..   ||.      .  . .. ||.|  .  .. .  ||  |.
msvrhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfih

DVIDMFF
 |.  .|
rvmlnyf

subfamily_egg_pd Subfamily egg 2084-2181 4.8e-06 20.5 In-house 180-271 (307) alignment
Range on Protein: 2084-2181
Range on HMM: 180-271/307.0
DWPTDGIVREPLTVLQVIddvihrqqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVV--DVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMFFK
|.   . |  || ||. .        .    ||||.. . ||....  .. ||| .     ..   | .  . .|. .. .| .  .|  .| .. .||.
dvnnssdvysplrvlrkl........rnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr





subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1970-2028 5.3e-06 20.5 In-house 25-81 (315) alignment
Range on Protein: 1970-2028
Range on HMM: 25-81/315.0
THSLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVD
 | |   .  . .|.  ..| . ||.|||  .| .|..|      |  ...||||||. 
fhdlpdPdiyrqrvaretinfkknryknilPldsarvklevid..dsPdsdyinasyik

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2109-2179 6.2e-06 20.0 In-house 219-289 (310) alignment
Range on Protein: 2109-2179
Range on HMM: 219-289/310.0
QKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRTKPGAVTTLEQYTSIYDVIDMF
 ..  ||.|||||  . | .| ... ..... .    ||. .|   .....   . |  ||. |  |  .|
aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif

subfamily_PTPRB_pd Subfamily PTPRB 1976-2028 8.3e-06 20.0 In-house 38-88 (293) alignment
Range on Protein: 1976-2028
Range on HMM: 38-88/293.0
GEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVD
|... ...  ...|.  ||..||  || .|. ||.    |  . .||||.|..
gkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyip

subfamily_PTPN12_pd Subfamily PTPN12 1972-2028 8.9e-06 19.8 In-house 23-77 (290) alignment
Range on Protein: 1972-2028
Range on HMM: 23-77/290.0
SLKSGEEKPCTVGYSEENSPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVD
 .|. .. . ..| .|||   ||.|.|  || .|. | .. . .  . .||||... 
kykaekvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfik