Gene PTPRD-47 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP103_AA protein Get Run
AqueP103_AA_729-883 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 720-883 3.9e-80 263.7 In-house 3-166 (301) alignment 
Range on Protein: 720-883
Range on HMM: 3-166/301.0
DELGTHVATCHSNGFDEQYEGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFW
..||||||..|||.|.|||. |..| ||.|..|..|||.|.||||||||||||||||.|...||.|||||||||||||||...||||.||||||||||||
edlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfW

RLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDDFGPFTVTLTNEQVYSDYVVRQISVTV
|||||||||||||||||||||||||||||||..|||..||||||||.||||| |.|.||..|..
rliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvki
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 716-883 3e-57 189.1 In-house 3-170 (305) alignment 
Range on Protein: 716-883
Range on HMM: 3-170/305.0
PVSVDELGTHV---ATCHSNGFDEQYEGLYTGiDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMK
....|.| ...    . ...|...||. ||.  .. . .| .|.|.| ||.|.||..||.||||... .||  ...||||||.|||....|.|..|||.|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDDFGPFTVTLTNEQVYSDYVVRQISVTV
.|..||||||..||...|||.|.|.|| |.||.||||.  .|. .||.|.|.|..|. .|||. |......
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisi
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 717-882 4e-52 171.9 In-house 2-169 (290) alignment 
Range on Protein: 717-882
Range on HMM: 2-169/290.0
VSVDELGTHVATCHS---NGFDEQYEGLYTGI-DKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQREYINASYIDGYSSSNKFIASQGPMK
. ||..| .||. |.   .|| .|.. | .|  ..   .|  ..|   |||.|| |||||||.| |  .   |. |||||.||.||. ....|| |||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraESDDFGPFTVTLTNEQVYSDYVVRQISVT
.||||||.||||||   |||.|| .|  | || ||||.   .....|.|...|.||.....|. |...|.
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevk
subfamily_PTPRD_pd Subfamily PTPRD 716-881 4.8e-50 165.8 In-house 4-168 (564) alignment 
Range on Protein: 716-881
Range on HMM: 4-168/564.0
PVSVDELGTHVATCHSN---GFDEQYEGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmCQREYINASYIDGYSSSNKFIASQGPMK
|..|.|| .|||  ..|    |.|.|. . .|   ..    ...| | ||..||. || .|..| . ..    . .|||||.|||| .....||.|||..
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPla

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGrAeSDDFGPFTVTLTNEQVYSDYVVRQISV
.|. ||||..|...  .|||.|.|.| .| ||..|||.    .  .| .||||..|. ..||..|....
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 717-882 4.6e-45 148.8 In-house 2-164 (287) alignment 
Range on Protein: 717-882
Range on HMM: 2-164/287.0
VSVDELGTHVATCHSN---GFDEQYEGLYT--GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILApnrkldMCQREYINASYIDGYSSSNKFIASQGPM
..|...|  ||. | .   || .|.  |      ..   ..  ..|   ||...| |.|..|..|        .. .||||..||||.....||....||
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPm

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAesDDFGPFTVTLTNEQVYSDYVVRQISVT
 .|...||.||.....  |||....|| ....| ||||....    .|.....|.||.|...|..|.. |.
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevk
0051299 (Phosphotyrosine protein) phosphatases II 733-883 3.6e-44 146.7 In-house 24-171 (288) alignment 
Range on Protein: 733-883
Range on HMM: 24-171/288.0
GFDEQYEGLYTGI-DKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
|. |..| |.  . |  . ... .||   ||...|  ||..|..| .  .  .    |||||||||| ...|||| |||...|. ||||..|...   ||
glleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIv

MVTNLKEGTKSKCEQYWPNgrAESDDFGPFTVTLTNEQVYSDYVVRQISVTV
|.|.| |  . ||.||||.   .|  .|..||||..|.|..||.||.. || 
mltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtn
subfamily_PTPRG_pd Subfamily PTPRG 717-881 3.1e-43 142.8 In-house 1-168 (563) alignment 
Range on Protein: 717-881
Range on HMM: 1-168/563.0
VSVDELGTHVATCHSNG---FDEQYEGLYTGIDKR---CIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQrEYINASYIDGYSSSNKFIASQGP
| |.|.  ||| .|..|   |.|..| | . . ..   .    ..||   ||  ||. ||  |. |.|    .    .||||.|||||  |..|||.|||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

MKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESDDFGPFTVTLTNEQVYSDYVVRQISV
.|.|. ||||.||...   |||.|||.| .. ||..|||.   || ..| ..|||..|.| . | ||....
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlvi
0040438 (Phosphotyrosine protein) phosphatases II 732-882 3.8e-43 143.3 In-house 18-164 (317) alignment 
Range on Protein: 732-882
Range on HMM: 18-164/317.0
NGFDEQYEGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
... |..| |.. .   . ... .||  .||...|  ||..|..| |  .       ||||||.||.. ..|||| |||...|. ||||..|...  .||
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MVTNLKEGTKSKCEQYWPNgrAESDDFGPFTVTLTNEQVYSDYVVRQISVT
|.|.|.|  . ||.||||.   |.  .|.|||||..|........|.. |.
mLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtleve
0050432 (Phosphotyrosine protein) phosphatases II 734-883 4.2e-43 143.2 In-house 44-190 (308) alignment 
Range on Protein: 734-883
Range on HMM: 44-190/308.0
FDEQYEGLYTGID-KRCIIGYNEENTAFNRFKNITVYDDNRIILapnrklDmCQREYINASYIDGY--SSSNKFIASQGPMKKTLVDFWRLIWQEKPVSI
..|..| |.   .   . ... .||  .||.|.|  || .|..|      |     ||||||.|||   ...|||| |||...|. ||||..|...   |
leeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvI

VMVTNLKEGTKSKCEQYWPNGRA-ESDDFGPFTVTLTNEQVYSDYVVRQISVTV
||.|.| |  . ||.||||.    .|  .|.|||||..|.|..||.||.. .| 
vmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltn
subfamily_PTPRA_pd Subfamily PTPRA 716-882 1.2e-42 141.0 In-house 13-179 (330) alignment 
Range on Protein: 716-882
Range on HMM: 13-179/330.0
PVSVDELGTHVAT---CHSNGFDEQYEGLYT-GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPM
|. |..|   .       .. | |... | .  |.  . .  .|||   ||. ||  || .|.||.. .  .  . .|||||.||||   .||||.||| 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaqGPk

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaeSDDFGPFTVTLTNEQVYSDYVVRQISVT
..|. ||||.||. |  .|||.|.|||  ..||.||||.    .  .|  .|.. .|.|  || ||.. |.
eetvedfwrmiweqksativmltelkerkeekcaqywPdeG..lvtyGnirvevedetvlvdytvrkflvq
0036941 (Phosphotyrosine protein) phosphatases II 747-883 1.2e-42 141.6 In-house 29-161 (297) alignment 
Range on Protein: 747-883
Range on HMM: 29-161/297.0
KRCIIGYNEENTAFNRFKNITVYDDNRIILapnrklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQ
  . .. ..||   ||.|.|  ||..|..|      |     ||||||.|||. ..|||| |||...|. ||||..|...  .|||.|.| |  . ||.|
gslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaq

YWPNGRAESDDFGPFTVTLTNEQV--YSDYVVRQISVTV
|||.   ||  .|.|||||....|  ..||..|.. || 
ywpleegesltygdftvtllsvevvllddytlrtlevtd
subfamily_PTPRB_pd Subfamily PTPRB 716-882 1.3e-42 140.9 In-house 6-173 (293) alignment 
Range on Protein: 716-882
Range on HMM: 6-173/293.0
PVSVDELGTHVATCHS---NGFDEQYEGLY-TGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPM
|...... .||.. ..    .| |.|| |   | |. . .  ...|.| ||..||  || .|. ||. .  |  . .||||.||.||.| ..|||.|||.
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyipgynsprefiatqGPl

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESdDFGPFTVTLTNEQVYSDYVVRQISVT
 .|. ||||..|..|   |||.|.| |. | |||.|||. . .   .|  .|||..|....|.|.|.....
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkie
0046845 (Phosphotyrosine protein) phosphatases II 734-883 2.5e-42 140.6 In-house 2-157 (284) alignment 
Range on Protein: 734-883
Range on HMM: 2-157/284.0
FDEQYEGLYTGIDK---RCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKlDMCQREYINASYIDGY-----SSSNKFIASQGPMKKTLVDFWRLIWQE
..|..| |.    |    . ... .||   ||.|.| .||..|..| .  . |.   .||||||.|||      ...|||| |||...|. ||||..|..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPVSIVMVTNLKEGTKSKCEQYWPNGrAESDDFGPFTVTLTNEQVYSDYVVRQISVTV
.   |||.|.| |  . ||.||||.   |.  .|.|||||..|.|..||.|| ...| 
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltn
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 717-882 1.3e-41 137.7 In-house 2-167 (318) alignment 
Range on Protein: 717-882
Range on HMM: 2-167/318.0
VSVDELGTHVATCHSNG---FDEQYEGLYTGIDKRCI-IGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMK
.||..| .||.  ...|   ..|.|| |    ..       .. | | ||. ||. ||. |. | .    .  . .||||.||||| .....||.|.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmle..geegsDyinanyidGyrrkkayiaaqaPlp

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESDDFGPFTVTLTNEQVYSDYVVRQISVT
.|. ||||..|. .   |||.|...| .| |...|||.   .|  .|  .|.|..|  .||||.|...||
etieDfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvt
0039614 (Phosphotyrosine protein) phosphatases II 730-882 1.4e-41 138.3 In-house 30-177 (297) alignment 
Range on Protein: 730-882
Range on HMM: 30-177/297.0
HSNGFDEQYEGLYTGIDKrCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMcQREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPV
 ........| |.  ..  . |.. .||  .||.|.|  ||..|..| |... |.    ||||||.|||.  ..||||.|||...|. ||||..|...  
sktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvt

SIVMVTNLKEGTKsKCEQYWPNGRAesdDFGPFTVTLTNEQVYSDYVVRQISVT
.|||.|.|.|  . ||.||||.       .|.|||||........|.||...||
vivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevt
0047943 (Phosphotyrosine protein) phosphatases II 746-883 1.9e-41 137.7 In-house 27-159 (273) alignment 
Range on Protein: 746-883
Range on HMM: 27-159/273.0
DKRCIIGYNEENTAFNRFKNITVYDDNRIILapnrklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCE
.  . ... .||  .||.|.|  ||..|..|      ..    ||||||.||| ...|||| |||...|. ||||..|...   |||.|.| |  . ||.
lltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekca

QYWPNGRAE-SDDFGPFTVTLTNEQVYSDYVVRQISVTV
||||.   | |  .|.|||||..|....||.||.. .| 
qYwpleggelsltygkftvtllseetkddytvrtleltn
0043336 (Phosphotyrosine protein) phosphatases II 730-882 3.4e-41 136.9 In-house 18-165 (278) alignment 
Range on Protein: 730-882
Range on HMM: 18-165/278.0
HSNGFDEQYEGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVS
   .. ...| |..     . |.. .||  .||.|.|  || .|..| .  .       ||||||.|||. ..||||.|||...|. ||||..|...  .
lktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMVTNLKEGTKSKCEQYWPngrAESDDFGPFTVTLTNEQVYSDYVVRQISVT
|||.|.|.|  . || ||||    .|  .|.|||||..|....||.||.. ||
ivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevt
subfamily_Ptp69D_pd Subfamily Ptp69D 719-882 1.4e-40 134.3 In-house 6-169 (307) alignment 
Range on Protein: 719-882
Range on HMM: 6-169/307.0
VDELGTHVATCHS---NGFDEQYEGLY-TGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKT
.|.| . . . .     |. . || |  . ||| . .. ..||.  ||...|. .|..|..|..    .  . .|||||.| ||  ..||||.|.|.  |
iddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveat

LVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraESDDFGPFTVTLTNEQVYSDYVVRQISVT
. ||||.|.. .   |||..||.| .. ||..|||.   .   .|   |.| .|.  |||. |...|.
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvs
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 725-881 1.5e-40 134.1 In-house 14-168 (288) alignment 
Range on Protein: 725-881
Range on HMM: 14-168/288.0
HVATCHSNGFDEQYEGL-YTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIW
.      .|| |.|. |   . .|   .| . .|   ||..||  || .|. |      .  . .|||||||||. ...|.||.|||. .|. |||.|..
kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkle..eeagaDYinasyidgekkkkkyiatqgPladtvndfWelvy

QEKPVSIVMVTNLKEGTKSKCEQYWPNGRaESDDFGPFTVTLTNEQVYSDYVVRQISV
..|   |||.|.| || |.|||.|||..  .   .| .||||....   |.|.|.. .
enktstivmltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrklll
0045450 (Phosphotyrosine protein) phosphatases II 732-883 4.5e-40 133.7 In-house 27-187 (307) alignment 
Range on Protein: 732-883
Range on HMM: 27-187/307.0
NGFDEQYEGLYTGIDK---RCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdMCQREYINASYI--------DGYSSSNKFIASQGPMKKTLVDFWR
.|. ...| |.   ..    . |.. .||  .||.|.|  ||..|..| .  .  .    ||||||.        ||| ...|||| |||...|. ||||
tgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

LIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGrAESDDFGPFTVTLTNEQVYSDYVVRQISVTV
..|...   |||.|.|.| .. || ||||.   |.  .|.|||||..|.....|.||.. || 
mlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtd
DSPc_SM00195 741-883 5.5e-40 132.7 In-house 9-151 (263) alignment 
Range on Protein: 741-883
Range on HMM: 9-151/263.0
LYTG-IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEG
| .   .|..  .  ..|.. ||.||| .||..|..| .. |    . .||||.||.|.....|.|| |||...|. ||||..|.||   |||.|. .| 
leestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

TKSKCEQYWPNGRAESDDFGPFTVTLTNEQVYS-DYVVRQISVTV
 | ||..|||.   .. .|| ..|.|.... .. ....|....| 
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltk
PTPc_SM00194 741-883 5.5e-40 132.7 In-house 9-151 (263) alignment 
Range on Protein: 741-883
Range on HMM: 9-151/263.0
LYTG-IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEG
| .   .|..  .  ..|.. ||.||| .||..|..| .. |    . .||||.||.|.....|.|| |||...|. ||||..|.||   |||.|. .| 
leestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

TKSKCEQYWPNGRAESDDFGPFTVTLTNEQVYS-DYVVRQISVTV
 | ||..|||.   .. .|| ..|.|.... .. ....|....| 
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltk
subfamily_PTPRK_pd Subfamily PTPRK 726-881 5.2e-39 128.9 In-house 16-162 (314) alignment 
Range on Protein: 726-881
Range on HMM: 16-162/314.0
VATCHSNGFDEQYEGLYTGIDKrciiGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQE
. .... || |.|| |. | |       ..|| . ||...|  ||  |..| .    .  . .||||..||.|  ...||. |||...|. |||||...|
lkraegygfkeeyeslfegwda....akkdenreknrsgdilaydrsrvflitid..gdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvyde

KPVSIVMVTNLKEGTKSKCEQYWPNgraESDDFGPFTVTLTNEQVYSDYVVRQISV
.  ||||.|.|.| .. || .|||.   ... .|.. |.| . .. ...|||  .|
ncasivmltelvevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 716-883 6e-39 128.8 In-house 5-170 (315) alignment 
Range on Protein: 716-883
Range on HMM: 5-170/315.0
PVSVDELGTHVAT---CHSNGFDEQYEGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILaPNRKLDmCQREYINASYIDGYSSSNKFIASQGPMK
|. .|.| |.||       ||| ..|| .  |  .   .  . ||   ||. ||  ||  |. | |  . |  . .|.||..||||.  ...||.|||  
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvql.pllend.phsdyvnanfidGynkkrryiaaqgpnv

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraeSDDFGPFTVTLTNEQVYSDYVVRQISVTV
 .. |||||...|.   |||.||| || |.|.|.|||.       .|..|||. .|.|...| || .||..
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvf
subfamily_PTPN6_pd Subfamily PTPN6 718-882 8.8e-39 128.3 In-house 12-177 (306) alignment 
Range on Protein: 718-882
Range on HMM: 12-177/306.0
SVDELGTHVATCHSNGFDEQYEGLYTGID---KRCIIGYNEENTAFNRFKNITVYDDNRIILApnrKLDMCQREYINASYIDG--YSSSNKFIASQGPMK
 |.||  .  . . .|| |..| | .           |   ||.  ||.|||  .|..|.||.   . .. . .||||.||..   .|....||.|| ..
rvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgcle

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDdFGPFTVTLTNEQVYSDYVVRQISVT
.|. ||||..|||.   |||.|.  | .|.|| .|||.  .... .|  .|| ..|.  .||..|..||.
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvs
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 731-882 1.1e-38 128.2 In-house 26-177 (298) alignment 
Range on Protein: 731-882
Range on HMM: 26-177/298.0
SNGFDEQYEGLYTGID----KRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEK
  |...... | .. .    .   .. ..||   ||. .|  .|  |..|  .   .  . .|||||....|. .| |||.|.|...|..||||....|.
ltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteed

PVSIVMVTNLKEGTKSKCEQYWPNGRaeSDDFGPFTVTLTNEQVYSDYVVRQISVT
  .|||.|||.|  | |...|||. .  .. .| .||.| ......|..||.. |.
igtiVmltnleeldktkyhkywPdeg..ketygeitvsllskeefadlivrklkvs
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 730-881 1.3e-38 127.8 In-house 13-162 (281) alignment 
Range on Protein: 730-881
Range on HMM: 13-162/281.0
HSNGFDEQYEGLYT-GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPV
...|| |.||.|.  |.|.     ...||.  ||..||. ||  |. ..|| .  ..  .||||....||.. ...||.|||. ..||.||...|..|  
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenknt..DYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

SIVMVTNLKEGTKSKCEQYWPNGRAeSDDFGPFTVTLTNEQVYSDYVVRQISV
 |||||.  |. | || .|||.... .  .| .||. |.|.  . |. |....
aivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkl
0045098 (Phosphotyrosine protein) phosphatases II 739-883 1.9e-38 127.9 In-house 15-143 (278) alignment 
Range on Protein: 739-883
Range on HMM: 15-143/278.0
EGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIIlapnrkldmcqrEYINASYIDGYssSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKE
. | .||  ..  .  ..| ..||.|.|  || .|..            .||||||||||  ..|||| |||...|. ||||..|...  .|||.|.|.|
fllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelve

GTKSKCEQYWPNgrAESDDFGPFTVTLTNEQVYSDYVVRQISVTV
... ||.||||.   .|  .|.|||||..|.|..||..| . || 
lgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtn
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 716-881 5.8e-38 125.7 In-house 4-168 (319) alignment 
Range on Protein: 716-881
Range on HMM: 4-168/319.0
PVSVDELGTHVATCHSNG---FDEQYEGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMK
.. |.|| ... . .|.|   ...... | .. ..      .|||   ||..||  ||  |..|..     . . .|||||.||||   .|||| |.|..
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqaPle

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAEsdDFGPFTVTLTNEQVYSDYVVRQISV
.|. ||||..|.|.   .||.|.|.|  | |...|||.   |  ..| ..||| .|.  .||..|....
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfe..eyGrlivtleeeeeledyiirklkl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 745-883 1.3e-37 124.2 In-house 21-154 (283) alignment 
Range on Protein: 745-883
Range on HMM: 21-154/283.0
IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldmcqrEYINASYID---GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTK
 |. . |  ..||  .||...| ..| .|. | .. .      .||||..|     |  ..|.|..|.|...| ||||.....|| ..|||.|.|.|. .
pdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlr

SKCEQYWPNgrAESDDFGPFTVTLTNEQVYSDYVVRQISVTV
 || ||||.    | |.|.||||| .|     ...... . |
ikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrv
Y_phosphatase Protein-tyrosine phosphatase 758-882 2.3e-37 124.0 Pfam-A 2-124 (235) alignment 
Range on Protein: 758-882
Range on HMM: 2-124/235.0
TAFNRFKNITVYDDNRIILapnrkL------DmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG
   ||.|.|..||..|. |            |     ||||.|..||....||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||. 
kkknRykdilpydktrvkl.....kgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

RAESDDFGPFTVTLT-NEQ-VYSDYVVRQISVT
. ||  .| ..|.|. .|.   ..|..|.....
eeesltygdikvelkekekedekeytlrklelk
Y_phosphatase Protein-tyrosine phosphatase 758-882 2.3e-37 124.0 In-house 2-124 (235) alignment 
Range on Protein: 758-882
Range on HMM: 2-124/235.0
TAFNRFKNITVYDDNRIILapnrkL------DmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG
   ||.|.|..||..|. |            |     ||||.|..||....||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||. 
kkknRykdilpydktrvkl.....kgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

RAESDDFGPFTVTLT-NEQ-VYSDYVVRQISVT
. ||  .| ..|.|. .|.   ..|..|.....
eeesltygdikvelkekekedekeytlrklelk
subfamily_PTPN9_pd Subfamily PTPN9 719-882 3.4e-37 123.1 In-house 3-165 (297) alignment 
Range on Protein: 719-882
Range on HMM: 3-165/297.0
VDELGTHVATCHSNGFDEQYEGLYTG-IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVD
..|| ..|   . .|  ..|. .    .  .        |   ||....  ||. |. ||   . .  . .||||...|||   . ||| |||.|||  |
ieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsd

FWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDDFGPFTVTLTNEQVYSDYVVRQISVT
|||..|... . |||.| . |  . || ||||... .|..|| ..|.  . ....||.||.. ..
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleik
0040439 (Phosphotyrosine protein) phosphatases II 749-882 5.2e-37 123.2 In-house 3-132 (249) alignment 
Range on Protein: 749-882
Range on HMM: 3-132/249.0
CIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
. ... .||   ||...|  || .|..| . ..|  .   |||||||||| ....||| |||...|. ||||..|...  .|||.|.|.|  . ||.|||
ysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PNgrAESDDFGPFTVTLTNEQVYSDYVVRQISVT
|.   .|  .| |||||....|..||.||.. .|
pl..ggsleygdftvtllsvevkddytvrtlelt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 752-882 7.3e-37 121.9 In-house 4-129 (250) alignment 
Range on Protein: 752-882
Range on HMM: 4-129/250.0
GYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSkCEQYWPNG
. . .|   ||. .|  .|  |..| ...  . .  .|||||...||. .. |||.|||...|..||||....||  .|||.|||||  |  ..||||  
akkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

RaeSDDFGPFTVTLTNEQVYSDYVVRQISVT
.  .. .|  ||.| ......||..|.. ..
k..aekyGdvtvsllskeefadytkrklkls
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 730-880 6.8e-36 118.7 In-house 17-165 (315) alignment 
Range on Protein: 730-880
Range on HMM: 17-165/315.0
HSNGFDEQYEGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPnrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVS
|.  | |..  |      |  .. ...|   ||.|||  .| .|..|      |  ...||||||| .. . . .|||||| | .. ||||...|||. .
htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklev..iddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtt

IVMVTNLKEGTKSKCEQYWPNGRAESDDFGPFTVTLTNEQVYSDYVVRQIS
|||||...|| | || ||||. .|.| .|| . |.| . .  .| |.|.. 
ivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklv
subfamily_PTPN12_pd Subfamily PTPN12 751-882 2.1e-35 117.0 In-house 34-164 (290) alignment 
Range on Protein: 751-882
Range on HMM: 34-164/290.0
IGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN
 | .|||.. ||.|.|  || .|. |  ... .  . .||||..| | ... ..||.|||. ||| ||||.||. .   .||. .. |  | |||.|||.
agekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

GRAESDDFGPFTVTLTNEQVYS-DYVVRQISVT
   |.  ||.|.|||..|.  . |...|.. |.
egeeelefgefevtleeekavdddflirtLkve
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 750-882 2.3e-35 116.7 In-house 36-166 (515) alignment 
Range on Protein: 750-882
Range on HMM: 36-166/515.0
IIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWP
 .  .| |   ||.|||  || .|..|      |  . .|.||||| .. . . .|||||| | .. |||||..||..  |.|||.|||| |.|| .|||
tvaqeeinfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

NGRAESDDFGPFTVTLTNEQVYSDYVVRQISVT
.  ..|  || . | |   .  .. . |.. |.
dkpgdsvkfGsikvelvsleactggikrkltvl
0042113 (Phosphotyrosine protein) phosphatases II 753-882 4.4e-35 116.7 In-house 5-130 (245) alignment 
Range on Protein: 753-882
Range on HMM: 5-130/245.0
YNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgr
. .||  .||...|  ||..|..| |      .   ||||||.|||  ..||||.|||...|. ||||..|...  .|||.|.. |  . ||.||||.  
llpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

AESDDFGPFTVTLTNEQVYSDYVVRQISVT
 ||  .| |||||..|....||.||...||
gesltygdftvtllseehlddytvrtlevt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 751-881 6.1e-33 109.3 In-house 42-169 (325) alignment 
Range on Protein: 751-881
Range on HMM: 42-169/325.0
IGYNEENTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLI--WQekpVSIVMVTNLKEGTKSKCEQYW
.    || | |||||.  .| .|..|    | |  . .||||||.  .   . |.|.| |. .|. |.|||.  |.    |.|.|.|  .. | .| .||
vamkpenkaknrfknvvaldksrvvle..tkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavyw

PNGRAESDDFGPFTVTLTNEQVYSDYVVRQISV
|.  ..|  ||.. | |   . .|||| |.. |
pkemgksktfGglevklrtieeisdyvhrvldv
subfamily_PTPN3_pd Subfamily PTPN3 737-882 7.3e-33 108.7 In-house 20-163 (280) alignment 
Range on Protein: 737-882
Range on HMM: 20-163/280.0
QYEGLYTGI-DKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKlDMCQREYINASyIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTN
|.| ||    .  . .    || . ||...|. ||. |..|  ... |    .|.|   |.. . .|..||.|||..||  |||...|..|   |||.|.
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnme.ipstglvnryiatqGPlaktatdfWqmvweqksslivmltt

LKEGTKSKCEQYWPNgRAESDDFGPFTVTLTNEQVYSDYVVRQISVT
| |  . || ||||.   .. ..| |.|....|.  . ||.|.. ..
lverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlk
0037934 (Phosphotyrosine protein) phosphatases II 750-882 2.6e-32 107.7 In-house 3-124 (243) alignment 
Range on Protein: 750-882
Range on HMM: 3-124/243.0
IIGYNEENTAFNRFKNITVYDDNRIILapnrklDMcqREYINASYIDGYsssNKFIASQGPMKKTLVD----FWRLIWQEKPVSIVMVTNLKEGTKSKCE
 |.  .||   ||...|  ||..|..|      .     ||||..|...   ...||.|||...|. |    |||..|...  .|||.|.|.| .. ||.
siallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPngraESDDFGPFTVTLTNEQVYSDYVVRQISVT
||||    ..  .|.|||||..|....||.|| ....
qywp....gevtygdftvtllseehlddytvrtllle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 756-882 2.9e-31 103.5 In-house 2-124 (237) alignment 
Range on Protein: 756-882
Range on HMM: 2-124/237.0
ENTAFNRFKNITVYDDNRIILAPNRKLdmcqREYINASYIDGYSSS-NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaE
|| . ||. ||..|| .|..|  .        .||||.|..|.  . .|.||.|||.. .  |||...||||   |||.| | || . || .|||.   .
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.q

SDDFGPFTVTLTNEQVYSDYVVRQISVT
   .| .||.|. .. .||| || . ..
paaygvltvslkkkeefsdytvrsllls
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 759-882 3.9e-31 103.1 In-house 30-155 (274) alignment 
Range on Protein: 759-882
Range on HMM: 30-155/274.0
AFNRFKNITVYDDNRIILAPNRKLDmCQREYINASYIDGYSSSN-KFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAE--S
  ||.|.|   .  |..| ..   |  . .|||| || ||.  .  ..| |||. .|. ||||.|.||.   |||.|.|||  ..||..|.|. .    |
tknryktilPnensrvllesessed.edssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

DDFGPFTVTLTNEQVYSDYVVRQISVT
. .| . .. ..     || ||.... 
erygdveikvekiverndysvrklvlk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 756-881 4.6e-31 103.3 In-house 60-175 (319) alignment 
Range on Protein: 756-881
Range on HMM: 60-175/319.0
ENTAFNRFKNITVYDDNRIILAPNRKLDMcqREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNGRAES
.|   ||. ||  .| |.. | .    ..   .|||||...|| . .|.||.|||.. || ||||.||. .  .||..|      | || ||||.   . 
qnkdknriinilafdknvvklerliGeef..sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

DDFGPFTVTLTNEQvySDYVVRQISV
.. .   |.. .|   ..||||.| .
eerfkvkvdsveet..aeyvvrdiel
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 756-881 8.1e-31 102.6 In-house 24-139 (284) alignment 
Range on Protein: 756-881
Range on HMM: 24-139/284.0
ENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNGRAES
.|   ||. .|  .| |.. | .    .    .|||||.| || . .|.||.|||.. || ||||.||. .  .||..|      | || ||||.   . 
qnkdknrighilafdknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

DDFGPFTVTLTNEQvySDYVVRQISV
.. .   |.. .|   ..||||.| .
eerfkvkvdsvees..eeyvvrdiel
subfamily_PTPN23_pd Subfamily PTPN23 754-882 1.3e-30 101.2 In-house 40-163 (288) alignment 
Range on Protein: 754-882
Range on HMM: 40-163/288.0
NEENTAFNRFKNITVYDDNRIILApnrkldMCQREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
 . ..  ||...|  || ||. |         . .|||||.. . |. . .|||.|.|...|| |||......|   |||... .|  | |...|||. .
aklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk

AESDDFGPFTVTLTNEQVYSDYVVRQISVT
 |.  ||...||| ...  . .| |.....
getvkfgdlsvtlksvretethvervlkle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 754-882 4.9e-29 96.4 In-house 48-169 (297) alignment 
Range on Protein: 754-882
Range on HMM: 48-169/297.0
NEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSsnKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNGRA
.  |   .|.|||  || .|..||     |  . .|.|||.. |.    ..|..| ||| |. |||.....|..  |||.....|..| || .||..   
kkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

ESddFGPFTVTLTNEQVYSDYVVRQISVT
 .  ||  .|.|.  .  . .. |...||
tt..fGdvsvvllsvsereGfikrelevt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 756-882 9.8e-29 95.2 In-house 19-146 (270) alignment 
Range on Protein: 756-882
Range on HMM: 19-146/270.0
ENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSS-NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAE
 ....||...|      |..|.. ..    . .|||| |. |.... .|.||..||.. || .|||.||.||  .|||.|.|.|  ..|||.|||. . |
rgkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

--SDDFGPFTVTLTNEQVYSDYVVRQISVT
  .  .|  .|. ..|.  . |..... ..
kvkledgkikvlalseekeegyiltrlrle
subfamily_PTPN14_pd Subfamily PTPN14 746-876 1.4e-28 94.7 In-house 38-169 (300) alignment 
Range on Protein: 746-876
Range on HMM: 38-169/300.0
DKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmcQREYINASYIDGYSSS--NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSK
|  .  . ..||.  ||||..  |.|||. |.|...    . .||||| |    ..   ..|..|||...|. |||...|...   |||.|. .|. | |
dallstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

CEQYWPNG--RAESDDFGPFTVTLTNEQVYSDYVV
. .|.|.   .... .|| | ||    .  . .. 
sfkyfPkleskkktvefgkfkvttkfsedsdsvit
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 757-879 2.6e-28 93.8 In-house 8-126 (239) alignment 
Range on Protein: 757-879
Range on HMM: 8-126/239.0
NTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAes
| | ||. ||  || .|..|   .  .  . .||||||.  |  | | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.  .  
nkaknryanivtydhsrvvle..klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

dDFGPFTVTLTNEQVYSDYVVRQI
  .  . ||| . .|..||..| .
.kycnlrvtlrktevfadyiirtf
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 757-879 2.8e-28 93.7 In-house 7-125 (239) alignment 
Range on Protein: 757-879
Range on HMM: 7-125/239.0
NTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAes
| | ||. ||  || .|..|   .  .  . .||||||.  |  | | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.  .  
nkaknryanivtydhsrvvle..klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

dDFGPFTVTLTNEQVYSDYVVRQI
  .  . ||| . .|..||..| .
.kycnlrvtlrktevfadyiirtf
subfamily_CG7180_pd Subfamily CG7180 748-882 8.7e-27 88.5 In-house 33-162 (296) alignment 
Range on Protein: 748-882
Range on HMM: 33-162/296.0
RCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQY
 |  |...||   ||  ..  || ||..|      .  . .||||.|.|..   ...|  ..|.|.|. .||||...|.  ..|..|.  . .| .. .|
dCagglrkenreknrdvkvvPyDynRvvLekldGee..ksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPNGRaeSDDFGPFTVTLTNEQVYSDYVVRQISVT
|||      ..|.. | ...|. |.. . |.. .|
wpnks..keqygeifveiveekqyanlkirtfklt
subfamily_PTPN13_pd Subfamily PTPN13 747-882 9.8e-27 88.9 In-house 27-158 (273) alignment 
Range on Protein: 747-882
Range on HMM: 27-158/273.0
KRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldmcqreYINASYIDGYSSSNKF--IASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
..| .| ..||.. ||..|.  ||. |..|  .         |||||.|      ...  ||.|||. .|  |||...|. |   |.|||. ||. | ||
dtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkc

EQYWPNGRAESDDFGP-FTVTLTNEQVYSDYVVRQISVT
..|||. . ..      ..|.| . | ....|||.. |.
hrywPesknkklkvsnrlevellkvqkldgfvvralavk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 757-881 3.7e-26 86.6 In-house 38-159 (287) alignment 
Range on Protein: 757-881
Range on HMM: 38-159/287.0
NTAFNRFKNITVYDDNRIILAPNRKLDMcqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGrAESD
..  ||. ..  .||.|..|. . .|     .|||| |. .|   ..|||.|||.  |. ||||......  |....|   | .. || .|||.      
avkknryadvlPiddtrvllsaegelGs...dyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPm

DFGPFTVTLTNEQV-YSDYVVRQISV
  | ..|.| . ..   .| || . .
rvGGysvvlldydikePeygvralrl
subfamily_PTPN1_pd Subfamily PTPN1 754-881 5.6e-25 82.6 In-house 29-153 (290) alignment 
Range on Protein: 754-881
Range on HMM: 29-153/290.0
NEENTAFNRFKNITVYDDNRIILAPNRKldmcqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRA
..|| . ||..... ||  ||.|  . .      .||||| ..      ..| .|||. .|   ||...|..|  ..||. .. |  . || ||||.|  
lpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-ESDDFG--PFTVTLTNEQVYSDYVVRQISV
 ..  .    ..|.| .|...| |.||.. .
ekellledtklkvkliseerksyytvrllel
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 730-850 7.8e-25 82.1 In-house 18-144 (392) alignment 
Range on Protein: 730-850
Range on HMM: 18-144/392.0
HSNGFDEQYEGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVS
||  | |..  |      .  .. .| |   ||.|||  || .|..|      |. ...|.|||||... . . .||||||   .| ||||...||.. .
hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkle..viddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvtt

IVMVTNLKEGTKS----KCEQY----WPN
|.|||.|||| |      . |.    ||.
iamvtklkegdkgddartvaqfhftewPd
subfamily_PTPRN_pd Subfamily PTPRN 744-878 4.2e-24 79.8 In-house 43-175 (297) alignment 
Range on Protein: 744-878
Range on HMM: 43-175/297.0
GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYID-GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKS
  .. . .. .|.|   || |..  ||..|. |   .. .  . .||||| |      .  .||.|||. .|. |||...|..  | ||..|.|.|   .
aepstkevakaeknvkknrskavlpydhsrvklk..eeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvk

KCEQYWPNGRAESddFGPFTVTLTNEQVYS-DYVVRQ
.|..|||.  .|   .. . | |  | ... ||.|| 
qckrywpdeGsev..yhiyevhlvsehiwcddylvrs
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 748-876 1.4e-23 77.9 In-house 48-168 (290) alignment 
Range on Protein: 748-876
Range on HMM: 48-168/290.0
RCIIGYNEENTaFNRFKNITVYDDNRIILApnrklDMCQREYINASYIDGYSssNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQY
| |.  | | .  ||.|...  |  |.||      |  . .|. | |..|      || .||..|.| .|.||.. |||   |||. .| |  |.|||||
rkifdkntefk.knrykdvvcndktrvilk.....dGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPNGRAESDDFGPFTVTLTNEQVYSDYVV
.|.   |   || .||. ..|.   . ..
ypekeGevltfGeitvlcseeddkdanii
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 760-866 4.6e-23 76.5 In-house 36-140 (297) alignment 
Range on Protein: 760-866
Range on HMM: 36-140/297.0
FNRFKNITVYDDNRIILapnrKLDMCQREYINASYIDG--YSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDD
 ||...|  .||.|. |    .  . .|.|||| |.      .  |.| .|||...|. |||.|....    ||||..|.|. ..||  |||.   |   
knryrdilatddtrvkl....lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlk

FGPFTVTLT
 | . |   
agdvvvefl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 748-880 7e-22 72.5 In-house 37-162 (439) alignment 
Range on Protein: 748-880
Range on HMM: 37-162/439.0
RCIIGY--NEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKskce
.||     .| . . ||.|... .|  |..|       . .  |||| ||.||   . .||.||| |.|  |||||....| | |||.||| |  |    
aciaslaaqeydqtknrykdvgafdhtrvtlqeip..gvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....

qYWPNGraESDDFGPFTVTLTNEQVYSDYVVRQIS
 |||    .   .|  .|    .    .||.| . 
.ywpsd..aevcygdiavrvdrnielpnyvirgfk
subfamily_egg_pd Subfamily egg 754-872 2.8e-21 70.5 In-house 37-151 (307) alignment 
Range on Protein: 754-872
Range on HMM: 37-151/307.0
NEENTAFNRFKNITVYDDNRIILapNRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtkSKCEQYWPNGRA
...|    | | .   |  |. |  . .  .   ..| | ...|    |.|| .| |.| |  ||||...||.   |||.|  ||    .|| |||.  .
sdnnlekarskrvhckdssrvkl..elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaes

ESDDFGPFTVTLTNEQVYS
.|  . | .. ..| .|.|
dslvtvpGslrienlkvds
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 756-854 1.8e-20 68.0 In-house 46-156 (350) alignment 
Range on Protein: 756-854
Range on HMM: 46-156/350.0
ENTAFNRFKNITVYDDNRIILA-----P-NRKLDMCQREYINASYIDGY------SSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSK
|  | ||.|||  |. .|..|      .  .|  .   .||||.|.          .. |.|| |.|...|. ||...| . |   |...|.. |    |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CEQYWPNGRAE
|..||..|  .
cyrYWqegsyd
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 746-877 2.4e-20 67.7 In-house 22-144 (267) alignment 
Range on Protein: 746-877
Range on HMM: 22-144/267.0
DKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtksKCE
  ..   . |.| ..||. .   |||.|.||  . .       ||||||..||   |.||. |.|.|.|  ||. .| ..|   ||..|.  ..   .  
sstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nir

QYWPNGRAESDDFGPFTVTLTNEQVYSDYVVR
..||   ...  .  .||  . |.   || . 
lfwPPkmgqakkyqdltvehslekeendyqii
subfamily_ptpA1_pd Subfamily ptpA1 752-879 5.3e-20 66.5 In-house 42-162 (418) alignment 
Range on Protein: 752-879
Range on HMM: 42-162/418.0
GYNEENTAFNRFKNITVYDDNRIILapNRKLDMCQREYINASYIDGYsSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG
| .. ||. ||. ||   .  |. |  ..  |    .|||| ||||    ..||..|||. .|. ||||..|...   |||..   |  . ||..|||. 
gdkkhntsknrytnilpvnhtrvql..kkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

RAeSDDfgpFTVTLTNEQVYSDYVVRQI
    ..   |..    ..|.  | |  .
ig.geq...fsiygngnevfgtysvelv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 756-866 9.1e-20 65.9 In-house 40-148 (307) alignment 
Range on Protein: 756-866
Range on HMM: 40-148/307.0
ENTAFNRFKNITVYDDNRIILapnrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAES
 ||  ||.... . | .||..    |.|    .|| | |.      .|||..|||...|  .|| .. |||  |..|. .. | .| |||||||  . . 
antdknryqdvkcqdkgrivv....kfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

DDFGPFTVTL--T
  ||  . |.  .
lvfgeapntisva
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 732-868 6e-19 62.7 In-house 27-159 (310) alignment 
Range on Protein: 732-868
Range on HMM: 27-159/310.0
NGFDEQYEGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
.|.  ||  | .  |        ...   ||. .. . |. |. |  ..       .|| | |.      . || ||||...|..||||.|.||.  ||.
eglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidks...ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MVTNLKEGTKSKCEQYWPNGrAESDDFGPFTVTLTNE
.. .  |  . ||  |||     .. .|   ||  .|
llckvgeegrpkcvgywpsl.gvtetygcirvtnlse
0051429 (Phosphotyrosine protein) phosphatases II 788-882 7.3e-19 63.9 In-house 5-111 (272) alignment 
Range on Protein: 788-882
Range on HMM: 5-111/272.0
EYINASYIDGYSS---SNKFIASQGPMKKTLVDFWRLiWQEKPVSIVMVTNLKEGTKSKCEQYWP----------NGRAESDDFGPFTVTLTNEQVYSDY
 ||||....|| .    .....|.||.. |  ||||| ....  .||..... |  . ||..|||          .  |..  .| ..|||. |....||
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VVRQISVT
..| . .|
ilrelllt
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 750-877 3.1e-18 60.4 In-house 30-156 (281) alignment 
Range on Protein: 750-877
Range on HMM: 30-156/281.0
IIGYNEENTAFNRFKNITVYDDNRIILAPNrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWP
 .  .  |   ||. || . |  |. |  .   .    .|| | ||        .| .||| |.|  ||||.||||.  .|||. .. |  . || .|.|
tvfnqpvnnkknrylnipcldisrvqlkvk.mpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

NGRAESDDFGPFTVTLTNEQVYSDYVVR
       .|  ..|.  .  |    |  
rnahcclqfdklsvsyedstvnkslvtt
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 754-867 3.7e-18 60.5 In-house 26-140 (285) alignment 
Range on Protein: 754-867
Range on HMM: 26-140/285.0
NEENTAFNRFKNITVYDDNRIILAPNRKLDMCQREYINASYIDGYS-SSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
|   ||..   ..  | | | |      |   .|.|| ||..       . .|..|||. .|| |||..|.|||   ..|.  | ||   ||  |.|.  
nctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

AESDDFGPFTVTLTN
 |   || . .|||.
gevvkfgkyeitlte
subfamily_CG42327_pd Subfamily CG42327 782-877 4.2e-18 60.1 In-house 51-149 (319) alignment 
Range on Protein: 782-877
Range on HMM: 51-149/319.0
LDMCQREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG--RAESDDFGPFTVTLTNEQVYSDYVVR
 |  . ||..|||. || .  | .||.| .....  ||||..|. .   || .|.| |    .| .|.|      . . .| . ||| . .|   |.. 
gdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryais
0049772 (Phosphotyrosine protein) phosphatases II 747-849 1.1e-17 60.2 In-house 36-164 (314) alignment 
Range on Protein: 747-849
Range on HMM: 36-164/314.0
KRCIIGYNEENTAFNRFKNITVYDdNRIILapnRKLDMCQREYINASYIDGYsssNKFIASQGPMKKTLVDF----------WRLI--WQEKPVSIVM--
. . ... ..|   ||...|  .| || ||    .|..    ||||||.||.   .||||.|||.. |.|||          ||..  .. ..  |||  
ltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsr

-------------------VTNLKEGTKSKCEQYWP
                    ..| ...   ......
devladelsrLdaAlgKtpllildgngneptaadle
0041856 (Phosphotyrosine protein) phosphatases II 757-851 1.8e-17 58.9 In-house 1-74 (182) alignment 
Range on Protein: 757-851
Range on HMM: 1-74/182.0
NTAFNRFKNITVYDDNRiilapnrkldmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtkskCEQYWPNG
|   ||...|  || .|               ||||....|.  ...||| |||...|. ||.|......  .||..|         .|.|||. 
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 757-854 4.7e-17 56.7 In-house 48-140 (305) alignment 
Range on Protein: 757-854
Range on HMM: 48-140/305.0
NTAFNRFKNITVYDDNRIILAPNrkldmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAE
..  ||.|..   |.||. | .         ||| | |.   . ...|| .| |..||  ||| . .|.|  .| |. ||.|    || .|..    .
eagknrykdvgcldnnrvklegp.....wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd
0036282 (Phosphotyrosine protein) phosphatases II 788-853 1.5e-14 49.6 In-house 3-63 (174) alignment 
Range on Protein: 788-853
Range on HMM: 3-63/174.0
EYINASYIDGYSSSNKFIASQGPMKktlvdFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRA
 |||||..|..  ....||.|||..     ||.......  ..||....||  . || .|||  | 
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelre
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 785-875 2e-14 48.0 In-house 73-163 (301) alignment 
Range on Protein: 785-875
Range on HMM: 73-163/301.0
CQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDDFGPFTVTLTNEQVYSDYV
 .|  | | .|.    ...|||.|||.|.|  ||| .. | .   |||...  | ...|||.| |   .|. | | |.....|...  .  
GkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 757-855 2.4e-14 47.7 In-house 55-149 (305) alignment 
Range on Protein: 757-855
Range on HMM: 55-149/305.0
NTAFNRFKNITVYDDNRIILAPNRkldmcQREYINASYIDGYS-SSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAES
. . ||.... . | . . |.          .|| | |.       ..||..|||. .|. .|| .. |.|   |||. .  |  | || ||||  . | 
aitknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek
fn3 Fibronectin type III domain 110-184 2e-13 43.5 Pfam-A 2-79 (85) alignment 
Range on Protein: 110-184
Range on HMM: 2-79/85.0
APSSLTEVNKTTTTITVSWTALD--SSDADGYVVNVTSDTDT--VQTVQVKGSSNnTITLNGLRGGTTYSITVRAYQQL
||. |.  . |.|..|.||.. .  ... .|| | . .....   ....|..... . ||.||. ||.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 796-865 2.5e-13 44.1 In-house 230-295 (440) alignment 
Range on Protein: 796-865
Range on HMM: 230-295/440.0
DGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTkskCEQYWPNgRAESDDFGPFTVTL
.|||  | |||.| |.  |..|||||. . .  .|.|. .|.. |   |  |||   . |  ||||||  
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpv.ntrsvtfgpftvgh
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 733-881 1.8e-12 41.9 In-house 20-158 (288) alignment 
Range on Protein: 733-881
Range on HMM: 20-158/288.0
GFDEQYEGLYTGIDKRCIIGYNeENTAFNRFKNITVYDDNRIILApnrklDMCQrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
| . .|.    .  .. |  .  .|.. .|..|.   |  |. |      | ..  ||.|  .      ...| .| |.. |.  .|... ..    |||
glkkeyrdspneasidiidsfi.anptrdryenlprcditrvkls.....ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivm

VTNLKEGTKSKCEQYWPNGRAESDDFGPFtVTLTNEQVysDYVVRQISV
...| |  | | ..|.|    |.  .| .  | . ..   . . . ..|
lcellekGkeksaeyfPsklGekarigrl.ctvvkkkr..adidklvkv
fn3 Fibronectin type III domain 483-563 2.6e-12 39.9 Pfam-A 2-85 (85) alignment 
Range on Protein: 483-563
Range on HMM: 2-85/85.0
SPSSIQVVQLNSTANRFTWNEVNcsERNGLITGYTVIISNS-----SITYNLTSTEKYIILNNLVFGTEYNISVAAVNSVGRGPFS
.|. ..| . .||  ...|.. .  ...| ||||.|  ...     . ......|..  .|..|  ||||...|.||| .| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
0046846 (Phosphotyrosine protein) phosphatases II 788-850 2.8e-12 42.2 In-house 13-71 (176) alignment 
Range on Protein: 788-850
Range on HMM: 13-71/176.0
EYINASYIDGYsssnKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN
 ||||..|.|.    ..|| |||. .|| ||........   .|..|...|  . || .||| 
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 716-809 4.6e-12 40.0 In-house 4-95 (95) alignment 
Range on Protein: 716-809
Range on HMM: 4-95/95.0
PVSVDELGTHVATCHSNG---FDEQYEGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcqreYINASYIDGYSSSNKFIASQG
|. |  . .||   |||    ||...  .         .|  | |   ||| ||  ||  |..|. .|  |     |||| ..|||.  | .||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsd.....yinacfvdgyarkncyiaaqg
0043147 (Phosphotyrosine protein) phosphatases II 787-841 4.7e-12 41.5 In-house 5-55 (172) alignment 
Range on Protein: 787-841
Range on HMM: 5-55/172.0
REYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLkegtK
. ||||||.|.|   ..||| |||.  || ||||......   ||..|.|     
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel....l
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 757-871 1.1e-11 38.7 In-house 48-171 (349) alignment 
Range on Protein: 757-871
Range on HMM: 48-171/349.0
NTAFNRFKNITVYDDNRIILAPNRK-----------LDMCQ-REYINASYID--GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKS
  | ||.|.|  |.  |..|    |            | ..  .|||| |.    .|  .|.|| | |.  |. ||...|  ..   .. ... || .  
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCEQYWPNGRaesddFGPFTVTLTNEQVY
||..|| ..      .  .|| | |   |
kcdiywqels.....ysnitvklqnssly
0049260 (Phosphotyrosine protein) phosphatases II 794-865 1.1e-11 40.2 In-house 1-72 (152) alignment 
Range on Protein: 794-865
Range on HMM: 1-72/152.0
YIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDDFGPFTVTL
.||||  ...||| |||.  || ||||.... .   |||.|.| | .| |||||.   .   .|.|. . . 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsq
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 747-834 3.4e-11 37.3 In-house 27-117 (347) alignment 
Range on Protein: 747-834
Range on HMM: 27-117/347.0
KRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDM---CQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVT
 ..     | . . || |.  . |. |..|.|..           |||||.|    .|...| .| |. .|. |||...   |   .| . 
skftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 801-881 1.2e-10 35.8 In-house 4-84 (199) alignment 
Range on Protein: 801-881
Range on HMM: 4-84/199.0
SNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDDFGPFTVTLTNEQVYSDYVVRQISV
  ..||.| |...|. |||...|.     |||| . .   ..    |||   . .  .| ..||     . .||..  . .
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalil
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 802-881 1.5e-10 35.6 In-house 4-83 (198) alignment 
Range on Protein: 802-881
Range on HMM: 4-83/198.0
NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDDFGPFTVTLTNEQVYSDYVVRQISV
 ..||.| |...|| |||...|.     |||| . .   ..    |||   . .  .| ..||     . .||..  . .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalil
fn3 Fibronectin type III domain 380-466 3.2e-10 33.2 Pfam-A 1-82 (85) alignment 
Range on Protein: 380-466
Range on HMM: 1-82/85.0
SPVTSLSVFNVSTTGIRVNWTIP-SSDNYVTYYTISYtpfCPQLSSV-NETVSvapyQSTTTYSYTLIGLYSGMNYTITVRAGNVLGES
|... ||| .|..| ....|. | . .  .|.|.. |   ... ..    ...     . ||.|.|| ||  |..|...|.| |  ||.
saPenlsvsevtstsltlsWsppkdgggpitgYevey...rekgggeewkeft....vprtttsvtltgLkpgteYefrVqavngageg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 757-844 3.5e-10 33.9 In-house 34-118 (332) alignment 
Range on Protein: 757-844
Range on HMM: 34-118/332.0
NTAFNRFKNITVYDDNRIILAPNRKLDmcqrEYINASYIDGYSSSNKFIASQGPMK-KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
|  .||   . ..| .|. |||.   |    .. |||..||||  . .| .| |.. .|   |||.. . ||  |... .. |  | |.
nmdmnriphlycfdhsrvelapqdgkd....dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 766-882 4.3e-10 34.2 In-house 27-151 (290) alignment 
Range on Protein: 766-882
Range on HMM: 27-151/290.0
ITVYDDNRIILAPNRKLdmCQREYINASYIDgYSSSNKFIASQGPMKKT-------LVDFWRLIWQEKPVSIVMVTNLKEGTKS----KCEQYWPNGRAE
...  ..|..|    |    . .|| |...  ...  ..|..| | .|.       . .|| .. |||  ..||. . .| ..      |..| |.   |
vpLveatrvvLkgygkr..fnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge

SDDFGPFTVTLTNEQVYSDYVVRQISVT
.  |. .||  ..     |  .|.. |.
elkfkgltvkCkskekeddvetRelvvk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 760-849 1e-09 32.6 In-house 46-129 (312) alignment 
Range on Protein: 760-849
Range on HMM: 46-129/312.0
FNRFKNITVYDDNRIILAPNRKLdmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWP
.||. || ..|  |. || . ..      || | ..   .  ..|...|||...| . ||.|      .||.... . | .  || .|  
lnrypniqcwdrgrftlagdenf......yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyis
0051082 (Phosphotyrosine protein) phosphatases II 788-850 2.1e-09 32.7 In-house 4-55 (151) alignment 
Range on Protein: 788-850
Range on HMM: 4-55/151.0
EYINASYIDGYsssnkFIASQGPMKktlvDFWRLIWQEKPVSIVMVTNLKEGTksKCEQYWPN
 |||.||..|.     ...|.||.     ||..|.....  .||......|    .| .|.|.
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpe
0044763 (Phosphotyrosine protein) phosphatases II 781-851 3.7e-09 32.0 In-house 12-73 (178) alignment 
Range on Protein: 781-851
Range on HMM: 12-73/178.0
KLDMCQREYINASYIDGYsssnKFIASQGPmkktlVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG
  ...  .|||||.|...     ...|..|     .|...|.....  .||..|. .|. . || .||| .
leglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpee
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 744-854 9.9e-09 29.0 In-house 41-144 (302) alignment 
Range on Protein: 744-854
Range on HMM: 41-144/302.0
GIDKrCIIgyNEENTAFNRFKNITVYDDNRIilapnrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTL---VDFWRLIWQEKPVSIVMVTNLKEGT
 ..| | .    .|...|. ... ..|.|..      ||.... .|.||| ..  . ... | .| | ...     .|||...||| ||.|..   .| .
dlek.Cka..fkknlkknqsedvpildsnlv......kleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelk

KsKCEQYWPNGRAE
|   ....|.   .
k.tlselfpkksgd
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 814-882 1.2e-08 29.4 In-house 40-106 (255) alignment 
Range on Protein: 814-882
Range on HMM: 40-106/255.0
TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDDFGPFTVTLTNeqVYSDYVVRQISVT
|.  |.. | | |.  .||.....| .. ||..|.|  . |   .   .|| |.    .| |.| . .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleit
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 753-869 1.3e-08 28.8 In-house 92-199 (244) alignment 
Range on Protein: 753-869
Range on HMM: 92-199/244.0
YNEENTAFNRFKNITVYDDNRIILApnrKLDMCqREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWqEKPVSIVMVTnlkeGTKSKCEQYWPNGR
.| .|.  ||      .| ||. |.   |  |    |||||..     . ..| .| |.  | .|||...  |. | ...|     |.  . ..|||.  
fnpnnswknregaglpfdfnrvpls...kgsmg.ntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvl....gsveeedeywpdse

AESDDFGPFTVTLTNEQ
         |||||. .
plewyeeditvtltdrd
subfamily_hpo-7_pd Subfamily hpo-7 812-882 5.8e-08 27.0 In-house 44-112 (263) alignment 
Range on Protein: 812-882
Range on HMM: 44-112/263.0
KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDDFGPFTVTLTNEQVysDYVVRQISVT
 .|.  |.. | | |.  .||... .|  . ||..|.|  . |   .   .|. |. |   | ... . ..
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlell
subfamily_eak_pd Subfamily eak 756-866 2.8e-07 24.3 In-house 51-157 (332) alignment 
Range on Protein: 756-866
Range on HMM: 51-157/332.0
ENTAFNrFKNITVYDDNRIILAPNRKldmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAES
|.   |   .|  || . . |.. ..    .  ||||| ..     .|.| .  . .. .  ||... ..|  .||.. .  |    | ..|.|.   | 
eavnrn.vvkivpydrylvrltssql...nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

DDFGPFTVTLT
 .|| . |.  
lkfGildverk
fn3 Fibronectin type III domain 296-362 4e-07 23.3 Pfam-A 2-76 (85) alignment 
Range on Protein: 296-362
Range on HMM: 2-76/85.0
PPNNVRGFILNATSIKVNWTNS----SETNGYVIEYTTGGVT--RNVVSTSEE--EIVLTDLSQMSTYTISVYSY
.| |..    ..||. ..|. .    ..  || .|| . | .   . .....   . .||.|   ..|...|...
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 729-800 2.9e-06 20.9 In-house 19-88 (440) alignment 
Range on Protein: 729-800
Range on HMM: 19-88/440.0
CHSNGFDEQYEGLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSS
  |  |....  | .|. . . |    .|   ||..|| .|| .|..|   .   . . .|||||||.|  |
rrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevk..gvpdsdyinasyingies
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 774-833 7.5e-06 19.7 In-house 56-114 (303) alignment 
Range on Protein: 774-833
Range on HMM: 56-114/303.0
IILAPNRKLDMCQREYINASYIDgYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMV
.|     |. ...  || |||..   ||.| | .| |. .|  |||..| ..|   ....
vicldhskvklsdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlll