Gene PTPRD-49 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP105_AA protein Get Run
AqueP105_AA_1157-1246 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1155-1253 1.2e-54 180.1 In-house 203-301 (301) alignment 
Range on Protein: 1155-1253
Range on HMM: 203-301/301.0
VVMIIKMRLKAKEKIIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETYGN
||   .. |.. ...|.. .|......|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||.|.||.|
vvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1172-1250 1e-31 105.3 In-house 210-288 (305) alignment 
Range on Protein: 1172-1250
Range on HMM: 210-288/305.0
TANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
. .| ..  ..||||..|.|.||...|.| ||..|.|.|||||.|.|..|......|.||.||....|..| ...  .|
dqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1166-1251 3.1e-28 93.5 In-house 204-289 (290) alignment 
Range on Protein: 1166-1251
Range on HMM: 204-289/290.0
KEKIIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETY
 |... |  |. .  |||||||||.||.|.|.. .....|| |||.||||| |  |  ||| |.| .||  |.... |||.  |||
ieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1167-1254 4.6e-26 86.5 In-house 200-287 (287) alignment 
Range on Protein: 1167-1254
Range on HMM: 200-287/287.0
EKIIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETYGNF
|. . |  |. .. ||||||||| ||...|.. .....|| |||.||||| |  |  |||.| | |||. |.|.. .||.  ||| .|
eemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_CG7180_pd Subfamily CG7180 1149-1249 6.3e-22 72.6 In-house 196-294 (296) alignment 
Range on Protein: 1149-1249
Range on HMM: 196-294/296.0
IPVI-IAVVMIIKMRLKAKEKIiitANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQM
.|..  |.. ....  . .||.    ..||.. .||..|| .||||||... . ||. . |. ||||.  | .|||.|. | . |.|  ||||.  .. .
vPlstnalielrrrvrlwrekv...dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc

NE
| 
nk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1175-1251 3e-21 71.0 In-house 220-296 (298) alignment 
Range on Protein: 1175-1251
Range on HMM: 220-296/298.0
KPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETY
.  .. ..|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  .|.  ...
qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1168-1251 8.1e-21 69.3 In-house 165-248 (250) alignment 
Range on Protein: 1168-1251
Range on HMM: 165-248/250.0
KIIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETY
|.  . .. ... ..|.||  |.||| .. ..  ||. | | |||||.| |..|. .|.||..|||| ..| .|  .|.  | |
kvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedy
subfamily_PTPRD_pd Subfamily PTPRD 1172-1250 1.4e-20 68.5 In-house 208-286 (564) alignment 
Range on Protein: 1172-1250
Range on HMM: 208-286/564.0
TANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
..|.|..  ||||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | | |||  |...|  .|.. .|
alnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1174-1251 3.2e-20 67.4 In-house 209-286 (318) alignment 
Range on Protein: 1174-1251
Range on HMM: 209-286/318.0
NKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETY
.|.... ||||||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | .||. ||||.  .|.  .|.
qksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1171-1250 4.6e-20 66.9 In-house 209-288 (319) alignment 
Range on Protein: 1171-1250
Range on HMM: 209-288/319.0
ITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
 . .|...  ||||||. | | | .. ... ||. | |||.|||.. . .|  ..  | . |||. ||...  .... .|
ksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
Y_phosphatase Protein-tyrosine phosphatase 1169-1241 2.8e-19 64.8 Pfam-A 166-233 (235) alignment 
Range on Protein: 1169-1241
Range on HMM: 166-233/235.0
IiitanKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
      .......|||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
k.....eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1169-1241 2.8e-19 64.8 In-house 166-233 (235) alignment 
Range on Protein: 1169-1241
Range on HMM: 166-233/235.0
IiitanKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
      .......|||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
k.....eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0050432 (Phosphotyrosine protein) phosphatases II 1168-1251 1.4e-18 62.7 In-house 229-305 (308) alignment 
Range on Protein: 1168-1251
Range on HMM: 229-305/308.0
KIiitankpEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETY
..       ....||||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|.|||  .|...  ||.  .|.
sl.......pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
0046845 (Phosphotyrosine protein) phosphatases II 1174-1252 2e-18 62.2 In-house 200-281 (284) alignment 
Range on Protein: 1174-1252
Range on HMM: 200-281/284.0
NKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETYG
| | ...||||||. |.|.|... . . ||| ..||   .|||... | .|. .||.|.|||||  .|...  ||..  |. 
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0040438 (Phosphotyrosine protein) phosphatases II 1170-1252 4.5e-18 61.0 In-house 201-283 (317) alignment 
Range on Protein: 1170-1252
Range on HMM: 201-283/317.0
IITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNETYG
. .|.........||||. |.|.|... . . |||.. || |||... | .|. .||||.|.|||  .||..  ||. ..|. 
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltle
0051299 (Phosphotyrosine protein) phosphatases II 1169-1245 6.9e-18 60.5 In-house 210-286 (288) alignment 
Range on Protein: 1169-1245
Range on HMM: 210-286/288.0
IIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
....|... .. .|||||. |.|.|... . . ||| ..||.|||... | .|. .||.|.|.|||  .|...  ||
lvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 1173-1250 7.8e-18 60.2 In-house 202-282 (297) alignment 
Range on Protein: 1173-1250
Range on HMM: 202-282/297.0
ANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
.. |......||||. |.|||... . . |.| .    || ||.... | .|. .||||.|||||  .|...  .|. ..|
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_PTPRK_pd Subfamily PTPRK 1173-1241 2e-17 58.0 In-house 205-273 (314) alignment 
Range on Protein: 1173-1241
Range on HMM: 205-273/314.0
ANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ...|. .||||||    |.|... ..| |.  . |||||||.. |..| .|.  | | |||. |||||
sqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
0047943 (Phosphotyrosine protein) phosphatases II 1174-1245 3e-17 58.4 In-house 201-272 (273) alignment 
Range on Protein: 1174-1245
Range on HMM: 201-272/273.0
NKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
. |.....|||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|.|||  .|...  ||
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
DSPc_SM00195 1169-1245 3.3e-17 58.0 In-house 194-262 (263) alignment 
Range on Protein: 1169-1245
Range on HMM: 194-262/263.0
IiitankpeKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
.        .. ||||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
s........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1169-1245 3.3e-17 58.0 In-house 194-262 (263) alignment 
Range on Protein: 1169-1245
Range on HMM: 194-262/263.0
IiitankpeKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
.        .. ||||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
s........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0039614 (Phosphotyrosine protein) phosphatases II 1166-1249 5.9e-17 57.5 In-house 219-293 (297) alignment 
Range on Protein: 1166-1249
Range on HMM: 219-293/297.0
KekiiitankPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNE
          |.. ...||||. |.|.|...   . |||.. || |||... | .|. .||||.|..||  .||..  .|. . 
l.........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
PTPc_DSPc_SM00012 1174-1241 7e-17 56.9 In-house 38-103 (105) alignment 
Range on Protein: 1174-1241
Range on HMM: 38-103/105.0
NkpeKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.   .. .|||||. |.|.|... ..| |.|...| . ||.||. |..|...||.|.|.|||  .|...
s...skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1167-1241 8.2e-17 56.0 In-house 188-262 (283) alignment 
Range on Protein: 1167-1241
Range on HMM: 188-262/283.0
EKIIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.|.|   .. .|. |||||| .. |..|....|  ... ..| |||||.| | .|  ...|| ||.||  .....
nkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPRA_pd Subfamily PTPRA 1172-1246 8.8e-17 56.0 In-house 222-296 (330) alignment 
Range on Protein: 1172-1246
Range on HMM: 222-296/330.0
TANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ
. |. . . ||||||  | |.| .. ..  ||. |||..||||.. | .|  .|  | |.|||. || |.  |  
klnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1174-1245 3.4e-16 54.0 In-house 208-280 (315) alignment 
Range on Protein: 1174-1245
Range on HMM: 208-280/315.0
NKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI-DTYL
.. . . ||||||. | |.| .....  |.| .|| ..||... . ||. . ..| ..|||  |||.. .|..
htnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfv
0043336 (Phosphotyrosine protein) phosphatases II 1169-1244 4e-16 54.8 In-house 201-276 (278) alignment 
Range on Protein: 1169-1244
Range on HMM: 201-276/278.0
IIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
....|.........||||. |.|.|... . . ||| . || ||.... | .|. .||||.|..||  .|...  |
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0045098 (Phosphotyrosine protein) phosphatases II 1168-1249 1.3e-15 53.1 In-house 196-276 (278) alignment 
Range on Protein: 1168-1249
Range on HMM: 196-276/278.0
KIIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVIDTYLQMNE
... .   ... ...||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..||||  .|...  .|....
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1172-1250 1.7e-15 51.6 In-house 204-282 (315) alignment 
Range on Protein: 1172-1250
Range on HMM: 204-282/315.0
TANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
. |....  ..||||  | |.|| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||..  .|.  .|
adngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt
0045450 (Phosphotyrosine protein) phosphatases II 1173-1244 2e-15 52.8 In-house 229-303 (307) alignment 
Range on Protein: 1173-1244
Range on HMM: 229-303/307.0
ANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
.. |......||||. |.|.|...   . |.| ..||.   ||.... | .|. .||||...|||  .|...  .
eelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_PTPRG_pd Subfamily PTPRG 1172-1250 2.5e-15 50.7 In-house 214-292 (563) alignment 
Range on Protein: 1172-1250
Range on HMM: 214-292/563.0
TANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
.||| |   ||||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |||. ..|..   .. .||
aankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_Ptp69D_pd Subfamily Ptp69D 1173-1250 2.5e-15 51.4 In-house 214-291 (307) alignment 
Range on Protein: 1173-1250
Range on HMM: 214-291/307.0
ANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
 .| ..| ||||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  .  | .. .|
lyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdt
0042113 (Phosphotyrosine protein) phosphatases II 1172-1244 5.9e-15 50.8 In-house 173-242 (245) alignment 
Range on Protein: 1172-1244
Range on HMM: 173-242/245.0
TankPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
    ... ...||||. |.|.|... . . ||| ..|. |..... | .|. .||||.|..||  .|...  .
e...dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0040439 (Phosphotyrosine protein) phosphatases II 1169-1244 8.2e-15 50.5 In-house 176-245 (249) alignment 
Range on Protein: 1169-1244
Range on HMM: 176-245/249.0
IiitankPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
.      |......||||. |.|.|...   . ||| . |. ||.... | .|. .||||...|||  .|...  .
l......pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1178-1250 2.3e-14 48.2 In-house 217-289 (297) alignment 
Range on Protein: 1178-1250
Range on HMM: 217-289/297.0
KSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
.. ..|||.  | | ||....   . . | |  ||.|.. | .|...|  | | |||. .| ..  .|  ..|
egPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1175-1246 3.2e-14 47.7 In-house 198-269 (274) alignment 
Range on Protein: 1175-1246
Range on HMM: 198-269/274.0
KPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ
. . . .|||||  . | |.. ..||.. | ..|.||||....  .|  . | | | |||  |. ..  ||.
naklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1179-1250 4.2e-14 46.5 In-house 210-281 (515) alignment 
Range on Protein: 1179-1250
Range on HMM: 210-281/515.0
SKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
  ...|||  | | ||..|.   . . |   .||||.. . .|. .|  | | |||. ||...  .|   .|
hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrnt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1169-1242 2.7e-13 44.6 In-house 203-276 (288) alignment 
Range on Protein: 1169-1242
Range on HMM: 203-276/288.0
IIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
.. .||. .  .|.||||. | |.|.. ..   ... ..| ..||. . . .|....  | ||.||  ||.|. 
qvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1170-1245 3e-13 44.6 In-house 213-288 (325) alignment 
Range on Protein: 1170-1245
Range on HMM: 213-288/325.0
IITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
 .|||    . |.||||. | |.||. |.   |..   |  ||.|.. | .|. .|  | | .||. ||. .  ..
rvtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
0037934 (Phosphotyrosine protein) phosphatases II 1160-1244 9.9e-13 43.7 In-house 160-241 (243) alignment 
Range on Protein: 1160-1244
Range on HMM: 160-241/243.0
KMRLKAKEKIIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCkaeGvVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVIDTY
..  .  |...   . .......||||  |.|.|...   . |...   | ||.... | .|. .|| ||.|..||  .|...  .
devrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1178-1244 1.8e-12 41.8 In-house 192-258 (267) alignment 
Range on Protein: 1178-1244
Range on HMM: 192-258/267.0
KSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
   .||.||| | ||| .  .   ||. | |||.|.|.  . .|  ..| | |.|.|  |....  |
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
fn3 Fibronectin type III domain 819-903 3.9e-12 39.3 Pfam-A 1-80 (85) alignment 
Range on Protein: 819-903
Range on HMM: 1-80/85.0
SPVTSLSVSNVSTTGITVSWTIP-SSDNYVTYYTISYTPSCPQLssVNETVSVGPHqpttTYSYTLIGLYSGMNYTITVRAGNVLG
|... ||||.|..| .|.||. | . .  .|.|.. | ..  .   .  ...| ..    |.|.|| ||  |..|...|.| |  |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprt....ttsvtltgLkpgteYefrVqavngag
fn3 Fibronectin type III domain 548-622 7e-12 38.5 Pfam-A 2-79 (85) alignment 
Range on Protein: 548-622
Range on HMM: 2-79/85.0
APSSLTKVSKTTTTITVSWTALD--SSDADGYVVNVTSDTDT--VQTVQVEGSSNnTITLNGLDIETTYSITVRAYQQL
||. |.  . |.|..|.||.. .  ... .|| | . .....   ....|..... . ||.||   |.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1172-1248 8.4e-12 39.2 In-house 312-388 (392) alignment 
Range on Protein: 1172-1248
Range on HMM: 312-388/392.0
TANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMN
..|.  .  |.|||     |.||.|.    . |      ||.||  | .|  .   | | |.|. .||||  ||  .
stnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafvydvireylhte
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1179-1241 1e-11 38.8 In-house 372-434 (440) alignment 
Range on Protein: 1179-1241
Range on HMM: 372-434/440.0
SKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
  |.|||   .  |||.|.|   ||| . .| .||||  . .| |.|  | || .|   | ..
ppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1171-1240 1.3e-11 39.4 In-house 217-286 (319) alignment 
Range on Protein: 1171-1240
Range on HMM: 217-286/319.0
ITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
.|  . .. .||||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
ltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_PTPN6_pd Subfamily PTPN6 1174-1250 1.3e-11 39.1 In-house 223-302 (306) alignment 
Range on Protein: 1174-1250
Range on HMM: 223-302/306.0
NKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNET
.. |.  ||||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | | .||  .| .| .|.. ...
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1170-1240 1.6e-11 39.3 In-house 180-250 (284) alignment 
Range on Protein: 1170-1240
Range on HMM: 180-250/284.0
IITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 .|  . ....||||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
hltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
0036282 (Phosphotyrosine protein) phosphatases II 1174-1239 1.8e-11 39.5 In-house 100-164 (174) alignment 
Range on Protein: 1174-1239
Range on HMM: 100-164/174.0
NKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
..... ...||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_PTPN12_pd Subfamily PTPN12 1174-1246 4.4e-11 37.2 In-house 203-278 (290) alignment 
Range on Protein: 1174-1246
Range on HMM: 203-278/290.0
NKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ
.. |.. .|||||  | | |. ... .  |. ||| .   .|||..   .|. .. .| | |||. .|  .  ..|
qesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPRB_pd Subfamily PTPRB 1173-1248 7.3e-11 36.6 In-house 213-288 (293) alignment 
Range on Protein: 1173-1248
Range on HMM: 213-288/293.0
ANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMN
 .. .|. ||||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |.... ..|. .
ektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_PTPN9_pd Subfamily PTPN9 1174-1245 8.4e-11 36.4 In-house 219-290 (297) alignment 
Range on Protein: 1174-1245
Range on HMM: 219-290/297.0
NKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYL
 .|..  ||||||  . |.| .... | |.. . .|.|||... | .|  .  .. | |||.  |  .  | 
ghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1174-1247 8.9e-11 36.3 In-house 192-266 (270) alignment 
Range on Protein: 1174-1247
Range on HMM: 192-266/270.0
NKPEKS-KIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQM
.. .|.  ..||||. | |.|.   . |...  . .. ||| .. ...|. ..  | . |||. .| .. .| ..
keldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
0051429 (Phosphotyrosine protein) phosphatases II 1172-1251 1.2e-10 37.0 In-house 149-247 (272) alignment 
Range on Protein: 1172-1251
Range on HMM: 149-247/272.0
TankpeKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD--------VFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ----------------M
.     . ...||||  ..|.|... . . |..  .| .||        .... . .|.  |||| | |||  .|...  .|                 .
d.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldai

NETY
.|.|
deey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1147-1241 2.9e-10 34.5 In-house 198-291 (297) alignment 
Range on Protein: 1147-1241
Range on HMM: 198-291/297.0
LLIPVIIAVVM-IIKMRLKAKEKiiITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. .|...|.|  .  | .   |   . |..| .  ..||||  | ||||     . |.. . . . ||  . . .|  ..  | ||||.. .||..
iavpmmlalvemftamvflqles..lraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_PTPN14_pd Subfamily PTPN14 1175-1246 4.8e-10 33.9 In-house 226-297 (300) alignment 
Range on Protein: 1175-1246
Range on HMM: 226-297/300.0
KPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQ
| .|  ..||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.|. .||.
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0041856 (Phosphotyrosine protein) phosphatases II 1170-1248 5.7e-10 34.5 In-house 107-174 (182) alignment 
Range on Protein: 1170-1248
Range on HMM: 107-174/182.0
IitankpEKSKIVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMN
       |. ...||||  |.|.|...   . ...    | |..... | ||. .||.|.|..||  .....  .|. .
e......eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1171-1238 6.1e-10 33.7 In-house 166-233 (239) alignment 
Range on Protein: 1171-1238
Range on HMM: 166-233/239.0
ITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
   . |     |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
tkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1171-1238 6.6e-10 33.6 In-house 167-234 (239) alignment 
Range on Protein: 1171-1238
Range on HMM: 167-234/239.0
ITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
   . |     |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
tkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
fn3 Fibronectin type III domain 935-999 7.2e-10 32.1 Pfam-A 18-85 (85) alignment 
Range on Protein: 935-999
Range on HMM: 18-85/85.0
LTWNEVNcsERNGLITGYTVIISNS-----SFTYNLTSTERYIILNDLVFGTEYNISVAAVNSVGRGPFS
|.|.. .  ...| ||||.|  ...     . ......|..  .|..|  ||||...|.||| .| ||.|
lsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_CG42327_pd Subfamily CG42327 1176-1244 9.8e-10 32.6 In-house 245-314 (319) alignment 
Range on Protein: 1176-1244
Range on HMM: 245-314/319.0
PEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
 ..  .|||||| | |.|.  .  | ... .     ||. |.   ||| .  || | |||  || |.  |
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1173-1243 1.2e-09 32.1 In-house 207-277 (439) alignment 
Range on Protein: 1173-1243
Range on HMM: 207-277/439.0
ANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
 .| |   .|||||  | |.|   .. | ||| |.|  ||.  . | .|. .   | .| ||  ||. .  
ndkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1168-1247 2.2e-09 31.8 In-house 198-278 (281) alignment 
Range on Protein: 1168-1247
Range on HMM: 198-278/281.0
KIIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQM
..  . .| .|  .|.|||  | |.|.| ..   .....||   .|| .| . .|...   | |. ||. .| ..  .|. 
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
0043147 (Phosphotyrosine protein) phosphatases II 1158-1239 2.4e-09 32.6 In-house 80-155 (172) alignment 
Range on Protein: 1158-1239
Range on HMM: 80-155/172.0
IIKMRLKAKEKIIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRRSKPGAVTTLEQYTSIYD
.... |.. | |   ... .. ...||||  |.|.|. .   . |        . ..... . ||. .||||.. .||  .|.
llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyy
0046846 (Phosphotyrosine protein) phosphatases II 1176-1245 3.1e-09 32.3 In-house 107-173 (176) alignment 
Range on Protein: 1176-1245
Range on HMM: 107-173/176.0
PEKSKIVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRRSKP-GAVTTLEQYTSIYDVIDTYL
 |. ...||||  ..|.|...        .. |  ..|... . ||. .| |||.| |||  .|...  .|
keggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_PTPN13_pd Subfamily PTPN13 1177-1247 4.6e-09 31.0 In-house 201-271 (273) alignment 
Range on Protein: 1177-1247
Range on HMM: 201-271/273.0
EKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQM
... ||||||  . |||.. .. . |.  . .  .|| .. . .|. . | | | .||  .| .| . |..
dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1178-1240 4.6e-09 30.7 In-house 135-199 (199) alignment 
Range on Protein: 1178-1240
Range on HMM: 135-199/199.0
KSKIVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 . ..|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1178-1240 4.6e-09 30.7 In-house 134-198 (198) alignment 
Range on Protein: 1178-1240
Range on HMM: 134-198/198.0
KSKIVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 . ..|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1163-1241 7.3e-09 30.2 In-house 156-235 (237) alignment 
Range on Protein: 1163-1241
Range on HMM: 156-235/237.0
LKAKEKIIITANK-PEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|. . .||  ... .| .  ..|||  | |.|..  .   | |.| . |||...  ...   .|  . | .||  |...|
lrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0049260 (Phosphotyrosine protein) phosphatases II 1170-1239 9e-09 30.7 In-house 81-144 (152) alignment 
Range on Protein: 1170-1239
Range on HMM: 81-144/152.0
IITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLeqckaeGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|  ... .. ...||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .|.
ieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0049772 (Phosphotyrosine protein) phosphatases II 1172-1249 2.8e-08 29.4 In-house 208-284 (314) alignment 
Range on Protein: 1172-1249
Range on HMM: 208-284/314.0
TAnkPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCkaeGVvDVFQVTKAVRRSKP-----GAVTTLEQYTSIYDVIDTYLQMNE
.|  .......|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .||||  |....  ||.. .
ea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1178-1238 3.7e-08 27.2 In-house 221-281 (302) alignment 
Range on Protein: 1178-1238
Range on HMM: 221-281/302.0
KSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
| ...||||  | |.|   ..  |.. |. . | |. .. . ||. . ||| . .| . . 
kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
0048076 (Phosphotyrosine protein) phosphatases II 1173-1242 5e-08 28.3 In-house 76-140 (145) alignment 
Range on Protein: 1173-1242
Range on HMM: 76-140/145.0
ANKPEKSKIVVHCSDTVSRSGVYCsvsiGLEQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
.  .|. ...||||  |.|.|...    ..  .. .| |..... . ||.  ||||.. .|.  .|... 
ealkeggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpgqlrflyefel
0051082 (Phosphotyrosine protein) phosphatases II 1165-1240 6e-08 27.9 In-house 79-148 (151) alignment 
Range on Protein: 1165-1240
Range on HMM: 79-148/151.0
AKEKIIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
|  ...  ...... ...||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
avleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
fn3 Fibronectin type III domain 734-800 7.6e-08 25.6 Pfam-A 2-76 (85) alignment 
Range on Protein: 734-800
Range on HMM: 2-76/85.0
PPNNVRGFILNATSIKMNWTNS----SETNGYVIEYTTGGVT--RNVISTSEDE--IVLTDLSPMSTYTISVYSY
.| |..    ..||. ..|. .    ..  || .|| . | .   . .......   .||.| | ..|...|...
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav
0044763 (Phosphotyrosine protein) phosphatases II 1169-1249 1.3e-07 26.9 In-house 101-175 (178) alignment 
Range on Protein: 1169-1249
Range on HMM: 101-175/178.0
IIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRRSKPgAVTTLEQYTSIYDVIDTYLQMNE
.| .| ........||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .|.  .|..   .|....
fieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1155-1249 1.7e-07 25.4 In-house 187-281 (287) alignment 
Range on Protein: 1155-1249
Range on HMM: 187-281/287.0
VVMIIKMRLKAKEKIIITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQMNE
 | .|.. |. |..| .. .  |   .|||..  . |||.. .. . ... .  | ||| .|   .|  . . | .  |.  .|. . || . | 
avglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnp
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1181-1242 2e-07 25.3 In-house 1-62 (69) alignment 
Range on Protein: 1181-1242
Range on HMM: 1-62/69.0
IVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
.|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| . 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
0048179 (Phosphotyrosine protein) phosphatases II 1174-1239 3.6e-07 25.6 In-house 79-139 (144) alignment 
Range on Protein: 1174-1239
Range on HMM: 79-139/144.0
NKPEKSKIVVHCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
  .|. ...||||  |.|.|...        .| .| ...... . ||.  ||||.. .|.  ...
aleeggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPN23_pd Subfamily PTPN23 1171-1243 5.4e-07 23.7 In-house 205-278 (288) alignment 
Range on Protein: 1171-1243
Range on HMM: 205-278/288.0
ITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
 . ... |  .|||||  | |.||.. |   ...  | .|..|. || . .|. .   | . ||.   |... .
eavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_PTPRN_pd Subfamily PTPRN 1178-1240 5.9e-07 23.5 In-house 224-287 (297) alignment 
Range on Protein: 1178-1240
Range on HMM: 224-287/297.0
KSKIVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 . ||||||| . |.|||. . . |..  |    .|.    . .|  .|| | | .|.  .. .
scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1182-1243 7.4e-07 23.4 In-house 1-62 (69) alignment 
Range on Protein: 1182-1243
Range on HMM: 1-62/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDT
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| .  
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_PTPN3_pd Subfamily PTPN3 1174-1241 1.1e-06 22.7 In-house 204-271 (280) alignment 
Range on Protein: 1174-1241
Range on HMM: 204-271/280.0
NKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 . ... .|||||  . |.||.  . . |    |.  | . .. . .|  .   | | .||. . . |
rsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1175-1242 2.3e-06 22.0 In-house 188-256 (290) alignment 
Range on Protein: 1175-1242
Range on HMM: 188-256/290.0
KPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
| .|. ..||| | .||| .  .. .|       .| | . .| ||.|. .  |.|. .... .  .| 
kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
fn3 Fibronectin type III domain 1016-1108 2.5e-06 20.7 Pfam-A 8-85 (85) alignment 
Range on Protein: 1016-1108
Range on HMM: 8-85/85.0
VSSImDTTWAVISWSVPSyiPSDYPIITYEIGYHILEYGNcsmvddddidiQMLQFSNSTNGNtIFNITGLNDMSCYIFGVRAYTDNGYGEWT
||..  .| ...||| |.  . . ||  ||. |   . |.           .  .|... . .  ...|||.  . | | |.|....|.|...
vsev.tstsltlsWsppk..dgggpitgYeveyrekggge...........ewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1179-1244 4.2e-06 20.6 In-house 217-282 (290) alignment 
Range on Protein: 1179-1244
Range on HMM: 217-282/290.0
SKIVVHCSDTVSRSGVYCSVSIGLeQCKAEG-VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTY
  .|||||  . |.| . .. .|| |.  .|  .|. .. .|.|.|. ..|    ||  . ...  .
GpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1167-1247 4.6e-06 20.3 In-house 208-287 (302) alignment 
Range on Protein: 1167-1247
Range on HMM: 208-287/302.0
EKIiITANKPEKSKIVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDTYLQM
.|.  . . . ....|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|.||.|.| .. .|.. 
akv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk