Gene PTPRD-5 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP106_AA protein Get Run
AqueP106_AA_485-761 phosphatase_domain Get Run
AqueP106_AA_772-1024 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 483-775 1.5e-187 618.4 In-house 2-294 (439) alignment 
Range on Protein: 483-775
Range on HMM: 2-294/439.0
VQRTEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSK
|.|.|||||||.|.||.||.||||||.||||||||.|.|.|.|||||.||||.||.||||||||.|||.|||||||||||||||||||||||||||.|.|
vgrdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkk

ETCDNFWRMVWEQKTVTIVMLTNVVDSFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMR
||.|.|||.|.|.||||||||||.|.|.||||||.|||||||.||.||||||||||||||||||.||...||||.||||||.||.|||||||||||||.|
ettddfwrlviekktvtivmltnlvesykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflr

AINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNH
|||||||..|.||||||||||||||||||||||||||||.||.|||.|||||||.||.||||.|||.|||||||||||||||....|||| ..
ainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkke
subfamily_PTPRD_pd Subfamily PTPRD 483-795 2.7e-105 348.2 In-house 5-321 (564) alignment 
Range on Protein: 483-795
Range on HMM: 5-321/564.0
VQRTEFQEHVEQLNKNNQEMFKEIFESINSTsPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSK
.. .|..|||..|..|..  |.| ...|..  .  ...|  . .     |||...| |.||.||||....|.. |.||||..|.||  .| ||||| | .
ipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpa..NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETCDNFWRMVWEQKTVTIVMLTNVVDSFK-----YWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVfnKRDRGKKERTILQFHYITWPNKNVPAQASHV
||...||||||||.. ||||||..... |     |||....  ||...|    . || .|.|| ||.  |. . .. |.. |||.. ||...|| .| ..
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpesatsl

LDFMRAINSANdSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYI
||..| ....| ... ||.||||||||||||| |..|. ||..|.|. ||| ..|| ||.||  |||. .|..||..|.|| .  |. .  ......|  
Ldlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlq

K-----SQEEATLITDEFNKIGA
|     ...| | .  ||... .
kLaeveedtemtgleleFqrLat
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 879-1040 1.2e-103 342.0 In-house 277-439 (439) alignment 
Range on Protein: 879-1040
Range on HMM: 277-439/439.0
TGLKFGAITISVGR-KKEFNAGFLTRDINIRNEEDSMLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESCHHGNHPILMHDDGSNGPIGIFATLT
  ...|.|...... ||||||||.||||.|.|||||.||..||||||.|.||.||||||||.||||.|||.|||||.||||||.||||||||.||||||.
edivyGdiavtidefkkefnagfstrdisifneedssllklkyiqyqemllkqcfprvdkfikfiqgclveveschrgnhpilihddgsngpvgifatla

YCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEYSNKLLKEEYFPSIHENIA
||||||||||||..||.|||||||||||||||||||||||||.|||.||||||..|||.||||
yclqrakkeriidllqsanhhylqspglivnlqfyaycydclleysdkllkeeslpsiyenia
0051299 (Phosphotyrosine protein) phosphatases II 483-758 5.8e-90 296.9 In-house 5-284 (288) alignment 
Range on Protein: 483-758
Range on HMM: 5-284/288.0
VQRTEFQEHVEQLNKNNQEMFKEIFESINSTSPDykCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSK
.. .|. ..|..| .|.. ...| || . |  ||  .. .  . .  ..|||..|| ..||.||.|. ..||..| ||||.||.||. .. .||||.| .
isveellklvlkllangltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

ETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNK--RDRGKKERTILQFHYITWPNKNVPAQAS
.|...||||||||.. .|||||..|.     ...|||... ..||||.|.  .  .|..|..| ..| |.   | ....||. .|||..||. .||  ..
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

HVLDFMRAINSANDsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
..|||.|....|.  .  ||||||||||||||||.||||..||||. |..||....|| ||.|| .||| ..|..|.| |.||
llldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 483-782 6.8e-89 293.0 In-house 2-302 (318) alignment 
Range on Protein: 483-782
Range on HMM: 2-302/318.0
VQRTEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSK
..  ....||..|... . ...| .| .. ..       .   .. ...|||. .| |.||||| ||.. |.. | ||||||| ||  .| |||.| |  
isvedleshvrrlresGelllseeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlp

ETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNkrDRGKKERTILQFHYITWPNKNVPAQASHV
||...||||||||.. .|||||.....      .||||..   ||..|| .. ..|| .||.| ||| .  .  ...|.. |.|| .||...||......
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpesgasl

LDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYI
||..| ...|. ... ||.||||||||||||. ||.|| ||..| |. ||. ..|| ||.||  |||   |..|||...|| .  ||. .  ......  
ldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrir

KSQEE
. .|.
elreq
0050432 (Phosphotyrosine protein) phosphatases II 484-761 1.5e-85 282.6 In-house 27-300 (308) alignment 
Range on Protein: 484-761
Range on HMM: 27-300/308.0
QRTEFQEHVEQlnKNNQEMFKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLqetpGvPHSHYINANYIKGY--YDDKLYIATQYPS
   .. ...|.  ...  ...| || ..|. |.......  ...  ..|||.||| ..||.||.|    . ..|.||||.|..||  . .. .||||.| 
svldllkllek..aldlglleeefeellsvkplleysva..llpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPl

KETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSD---DEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgkKERTILQFHYITWPNKNVPAQ
..|...||||||||.. .|||||. |.      ..|||..   . ..||...|.  .  .|..|..| ... |..|   ..||. .|||..||. .|| .
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthfhytnWpdhgvPps

ASHVLDFMRAINSANDSkecGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
....|||...... ...   ||.|||||||||||||.||||..||||. |..||....|| ||.|| .||| . |..|.| |.|| . 
peilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 485-773 3.6e-85 280.9 In-house 7-296 (319) alignment 
Range on Protein: 485-773
Range on HMM: 7-296/319.0
RTEFQEHVEQLNKNNQEMFKEIFESINSTSPDykcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKET
  |..|....|... . .... |. .. ...|   . .   .| ...|||...| |.|.|||||.| .||. | ||||..| || . . .|||| | ..|
vqeLkerlkalastgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

CDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVfNKRDRGKKERTILQFHYITWPNKNVPAQASHVLD
 ..|||||||... ..||||..|.       ||||. . . || ..|  . . || .|.|| .|. ||.    . |.. .|.|  ||...|| .|  .||
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslld

FMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFS
... |. . . .. ||.||||||||||||| |.||..||..| |. .|.  .|. || ||  |||.  |. |||.|.|| .  ||    .... 
llkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlr
0040438 (Phosphotyrosine protein) phosphatases II 487-781 1.4e-84 279.4 In-house 4-297 (317) alignment 
Range on Protein: 487-781
Range on HMM: 4-297/317.0
EFQEHVEQLNKNNQEMFKEIFESINSTSPDykcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCD
.. .....|.|..  ...| || . | ..|   . .  . .  . |||..||  .||.||.|. ..|...| ||||.|..|..  . .||||.| ..|..
dlllalldllksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntve

NFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKrdRGKKERTILQFHYITWPNKNVPAQASHVLDFM
.||||||||.. .|||||. ..      ..|||..... |||..|.    .||.....| ..| ..  .....||. .|||..||  .||   ...|||.
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfl

RAINSANDsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYIKSQE
.|...|.. .. |||.||||||||||||.||....||||. |..||.| .|| ||.|| ..|| . |..|.| |.|| . ...... . |. ....| ..
eavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklli
0046845 (Phosphotyrosine protein) phosphatases II 504-762 1.4e-83 275.8 In-house 3-276 (284) alignment 
Range on Protein: 504-762
Range on HMM: 3-276/284.0
KEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGV-PHSHYINANYIKGY-----YDDKLYIATQYPSKETCDNFWRMVWEQKT
.| || ..|  ... .. .  . .  ..|||.||| ..||.||.|. ..|  ..|.||||.|..||     |  | .||||.| ..|...||||||||..
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

VTIVMLTNVVD-----SFKYWPSDD-EVCYGDIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDS-
 .|||||. |.      ..|||...  . |||. |.  .  . ..|..| ... |. . ....||. .|||..||. .||......|.|.|........ 
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

KECGPVVVHCSAGVGRTGTIIALDIALEQLKSEN---RVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVY
.  ||.|||||||||||||.||||..||||. |.   .||....|| ||.|| .||| | |..|.|.|.|| . .
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_PTPRB_pd Subfamily PTPRB 482-758 2.5e-83 274.5 In-house 6-283 (293) alignment 
Range on Protein: 482-758
Range on HMM: 6-283/293.0
NVQRTEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPS
... ..|.|||........  |.| .|....   | ...|.  |.  ...|||...| ..||.|| |... . ..| |||||||.||   . .|||| | 
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelav..nraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

KETCDNFWRMVWEQKTVTIVMLTNVVDSFK-----YWPSD-DEVCYGDIVVRADRNIELPNYVIRGFKVFNkrdrGKKERTILQFHYITWPNKNVPAQAS
 || |.|||||||.|. .|||||..|.  |     |||.| ..| |||| |    . || ..||| .|. .    .|.||.. |.|...||. .|| ...
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektk

HVLDFMRAINSAN-DSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
 .|||.|....|  .... .|.||||||||||||| ||||  |.....|. ||| |||  ||..|...||   |..||...||.
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
subfamily_Ptp69D_pd Subfamily Ptp69D 483-776 5.9e-83 273.5 In-house 4-302 (307) alignment 
Range on Protein: 483-776
Range on HMM: 4-302/307.0
VQRTEFQEHVEQLNKNNQEMFKEIFESINSTspDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSK
... . .| ... ... .. ... .|.....    . ...  ... .  |||..|| |||.|||.|....|  .| ||||..|||| . | .|| | |  
iaiddleealksrkrdtdfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETCDNFWRMVWEQKTVTIVMLTNVVDSFK-----YWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRG---KKERTILQFHYITWPNKNVPAQA
.| ..||||..||.  .||||.|. .  .     ||| .||| ||||.|.  .. . ..|.|| ..| .| . .   ...| ..|.|| .|.. .|| .|
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

SHVLDFMRAINSANDSKeCGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSN
  .|.... ... .  .  .|.||||||||||.|...|||. |.||| |..|||  .|| ||.||. .|| | |.||.| |.|. . |||    .|....
rgllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

HY
..
ai
subfamily_PTPRA_pd Subfamily PTPRA 487-780 4.8e-82 270.5 In-house 18-315 (330) alignment 
Range on Protein: 487-780
Range on HMM: 18-315/330.0
EFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDatLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCD
...| ...   .. ..|.| |... ... .  ..  | ..| .. |||. .|  .|..||.|..  ||..| |||| .|.|| . . .||.| | .|| .
kleeeirirsaddnklfreefnalPagpiqatle..laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetve

NFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRG--KKERTILQFHYITWPNKNVPAQASHVLD
.||||.||||. ||||||.. .       .|||..  | ||.| |  . . .| .| .| | | .. |    ||.| . |||. .||.  ||...  .|.
dfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlk

FMRAINSANDSkECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDmsTLIDEFS--NHYI
....... |.  ..||.||||||||||||| |.||  ||..|.|..||. ..|| ||.||.|||| . |..|||...||  .|||  | .| .|  .|  
llkkvkklnqq.sagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygd..teldvsslekhlq

KSQ
| .
kly
0043336 (Phosphotyrosine protein) phosphatases II 484-758 4.9e-81 267.5 In-house 3-275 (278) alignment 
Range on Protein: 484-758
Range on HMM: 3-275/278.0
QRTEFQEHVEQLNKNNQEMFKEIFESINSTSPdykCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKE
.. ........|..|.. .... ||...|  .   .. .  . .  ..|||.||| ..||.||.|. ..|...| ||||.|..||   . .||||.|..|
svkdllkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPsDDEVCYGDIVVRADRNIELPNYVIRGFKVFNkrDRGKKERTILQFHYITWPNKNVPAQASHVL
|...|||||||... ||||||. |.     ...||| .. ..|||..|.  . ..|..|..| ..| |   . ...||....||. ||  .|| . |..|
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslslll

DFMRAINSANDsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
||..|...|.. .. |||.||||||||||||.|||...||||..| .||.| .|| ||.|| ..|| . |..|.|.|.||
dflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPRG_pd Subfamily PTPRG 486-767 2.8e-80 265.1 In-house 4-294 (563) alignment 
Range on Protein: 486-767
Range on HMM: 4-294/563.0
TEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHS-HYINANYIKGYYDDKLYIATQYPSKET
 ||..|| .|  ...  |.| ||...|.. . . ||.   .. .. |||  .| |.|..|| |...||. ..  |||||||.||.  | .||||.|.|.|
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

CDNFWRMVWEQKTVTIVMLTNVV-----DSFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFN-KRDR---GKKERTILQFHYITWPNKNVPAQAS
.| ||||.|||.. .|||.||.|     . . |||.|. . || . |.  ..  |  | .| ... | | ..    ..|... |.|| .||...|| .. 
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl

HVLDFMRAInSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMST
 || |..   ||   .| ||.||||||||||||| |.||  |.|...|| |.. |..| .| ||  .||.  |..|...|.|| |  ..   
pvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketel
0045450 (Phosphotyrosine protein) phosphatases II 485-758 6.6e-80 264.4 In-house 11-302 (307) alignment 
Range on Protein: 485-758
Range on HMM: 11-302/307.0
RTEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGV-PHSHYINANYI--------KGYYDDKLYI
.. .  .| .| ... . ... ||...|  ... .. .  . .  ..|||.||| ..|||||.|. ..|  ..|.||||.|.        .||. .. .|
alkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfI

ATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDEV-CYGDIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKN
|||.| .||...||||.|||.. .|||||. |.      ..|||...|. .||...|.  .  .|..|..| ..| .. |  ...||. .|||..||. .
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhg

VPAQASHVLDFMRAINSANDSK-ECGPVVVHCSAGVGRTGTIIALDIALEQLKSENR---VDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
||   ...|||......|...  . |||.||||||||||||.||....|.||..|.    ||.. .|| ||.|| ..|| . |..|.|.|.||
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0047943 (Phosphotyrosine protein) phosphatases II 496-758 8.7e-80 263.4 In-house 7-270 (273) alignment 
Range on Protein: 496-758
Range on HMM: 7-270/273.0
NKNNQEMFKEIFESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLqetpGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQ
....  ...| || . |. |.... ..|. .   ..|||.||| ..||.||.|    | ..|.||||.|..||.  . .||||.| ..|...||||||||
kllgltllleefelllslkplltysvallpe..nkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

KTVTIVMLTNVVD-----SFKYWPSDD---EVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgkKERTILQFHYITWPNKNVPAQASHVLDFMRAINSA
.. .|||||..|.      ..|||..    .. ||.. |.  .  . ..|..| ... |. .   ..||. .||| .||. .||.. ...|.|......|
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtg..esrtvthfhytgwpdhgvppslesllefielvrka

NDSK-ECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
. .  . ||||||||||||||||.||||..|.||. |..||.. .|| ||.||  ||| ..|..|.|.|.||
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 495-771 9.7e-80 263.3 In-house 7-288 (297) alignment 
Range on Protein: 495-771
Range on HMM: 7-288/297.0
LNKNNQEMFKEIFESINSTSPDYKCDATLMAqeYDHTKNRFKDIGAFDHTRVVLqetpGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWE
 ....  .... ||.. .  ........|       .|||.||| ..|||||.|    . ..| ||||.|..||. .. .||||.| ..|...|||||||
ekllflalllkefeellpllllgslsvallp..enleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

QKTVTIVMLTNVVD-----SFKYWPSD--DEVCYGDIVVRADRNIE--LPNYVIRGFKVFNKrdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAIN
|.. .|||||..|.      ..|||..  ....|||..|.  .  .  |..|..| ..| ..  .....||. .|||..||  .||  ....|||.....
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvr

SANDSK-ECGPVVVHCSAGVGRTGTIIALDIALEQLK---SENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDE
....   . |||.|||||||||.||.||.|..|.||.    |..|||  .|| ||.|| ..|| | |..|.| |.|| . ....   ...
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0039614 (Phosphotyrosine protein) phosphatases II 484-759 1.3e-79 263.1 In-house 15-288 (297) alignment 
Range on Protein: 484-759
Range on HMM: 15-288/297.0
QRTEFQEHVEQLNKNNQEMFKEIFESINSTSPDykcdATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGV-PHSHYINANYIKGYYD-DKLYIATQYPS
. . .  ..  ...|.  .... ||.. |  ||     .  . .   .|||.||| ..||.||.|.  .|| ..| ||||.|..||.  .. .||||.|.
plsvldlllllekansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

KETCDNFWRMVWEQKTVTIVMLTNVVD----SFKYWPSDDEvCYGDIVVRADRNIELPNYVIRGFKVFNkrdrGKKERTILQFHYITWPNKNVPAQASHV
.||...||||||||.. .|||||. |.     ..|||.. . .|||..|.  . ..|..|..| ..| |    ....||. .|.|. ||  .||  ....
petvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslell

LDFMRAINSANDSK-ECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLED
|.|......|. .  . |||.||||||||||||.||....||||..| .||.. .|| ||.|| ..|| . |..|.|.|.|| 
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 486-763 3.2e-78 258.0 In-house 12-293 (298) alignment 
Range on Protein: 486-763
Range on HMM: 12-293/298.0
TEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQ-EYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKET
. .|. ..  .|..   ... |. .||.| . . . . .|. .... |||. || |.|..||||... .  .| |||| ....| . . .||||.| .||
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltet

CDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgkKERTILQFHYITWPNKNVPAQASHVLD
  .|||||.|..  |||||||....      ||||.. .  ||.| |.  .. |  ....| .|| .|. .  |||.. |.|...||.| ||..|. |||
vedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvld

FMRAINSanDSKECG--PVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYG
..| ..     ...|  ||.|.|||||||.|| ||.|  ||..| |. ||.  .|||||..|...||   |.||||.|||| .  .
llrkvra..sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
DSPc_SM00195 503-758 1.5e-77 255.8 In-house 2-260 (263) alignment 
Range on Protein: 503-758
Range on HMM: 2-260/263.0
FKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVM
.|| ||....  .. ... .  ...  ..|||.|.|  .||||| |..... ..| |||||||||.  .| |||||.| ..|.. |||||||.|. .|||
lkeefekleestspkettea..ekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LTNVVD-----SFKYWPSD--DEVCYGDIVVRADRNIELP-NYVIRGFKVFNKRDrgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKeCG
||. ..       .|||..  ..  .|.| |   .... . ....| ... .. .  ...|.. |..| .||...|| ....||...||... ....  |
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sg

PVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
|.|||||||||||||....||.|..|..|..|||. ||| ||.|| .|||.| |. |||.|.||
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 503-758 1.5e-77 255.8 In-house 2-260 (263) alignment 
Range on Protein: 503-758
Range on HMM: 2-260/263.0
FKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVM
.|| ||....  .. ... .  ...  ..|||.|.|  .||||| |..... ..| |||||||||.  .| |||||.| ..|.. |||||||.|. .|||
lkeefekleestspkettea..ekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LTNVVD-----SFKYWPSD--DEVCYGDIVVRADRNIELP-NYVIRGFKVFNKRDrgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKeCG
||. ..       .|||..  ..  .|.| |   .... . ....| ... .. .  ...|.. |..| .||...|| ....||...||... ....  |
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sg

PVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
|.|||||||||||||....||.|..|..|..|||. ||| ||.|| .|||.| |. |||.|.||
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_PTPRK_pd Subfamily PTPRK 484-790 1.7e-76 252.1 In-house 5-312 (314) alignment 
Range on Protein: 484-790
Range on HMM: 5-312/314.0
QRTEFQEHVEQLNKNNQEMFKEIFESINSTspdykCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKE
.  .  ... .|....   ||| .||.         ||.   .. ...|||..|| |.|..||.|. . | |.| ||||..| .|   . .|.||.| .|
rvadllqsiallkraegygfkeeyeslfeg.....wdaa..kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqe

TCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDDEVcYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQASHVL
|  .|||.|..... .|||||..|. .     |||| | || |||| |   .   | ..|.| |.| .     .. |.. ||....||. .|| .|  .|
tvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgll

DFMRAINSANDSkECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYIK
...| ... ..  | |..||||||| ||||| ||.|| |. .. |. ||.  .|| ||.... ||.   |..|||...||  . |. .  . || . |..
klvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

S-----QEEATLITDEF
|     | ... . .||
sirldpqtnssqlkeef
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 488-758 3.6e-76 251.0 In-house 8-277 (288) alignment 
Range on Protein: 488-758
Range on HMM: 8-277/288.0
FQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDN
  ..| . ...|.. |.| ..|. .   . . .|.   .  ...|||...| ..|..|| |.. . .. . ||||.||.|.  .| ||||| |  .| ..
pvakvakksarnrtgfseeynsLaalektksvtag..rlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvnd

FWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDE-VCYGDIVVRADRNIELPNYVIRGFKVFnkrdRGKKERTILQFHYITWPNKNVPAQASHVLDFM
||..|.|.|| ||||||..|.       .|||..|. . ||.. | .  . || ..| | . .     . |.|..| |..| .||...||...  .|...
fWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllell

RAINSANDSKeCGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
| .. ||...  ||..|||||||||||| |||| .......|. .|. |.|. ||.||...||.| |..|||...|.
rqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 489-760 1.3e-74 245.8 In-house 3-276 (281) alignment 
Range on Protein: 489-760
Range on HMM: 3-276/281.0
QEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNF
..|..||..|... |.| .|....   |    |.   .. . .|||...| |.|.|||.....    .. |||||...|| ..| ||||| |  .....|
rkhlkqlsqndnaGfieeyeklaaigvdntatas..kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvaf

WRMVWEQKTVTIVMLTNVVDS-----FKYWPSDD-EVCYGDIVVRADRNIELPNYVIRGFKVfnKRdRGKKERTILQFHYITWPNKNVPAQASHVLDFMR
|.||||||  .|||.|. ...      .||| |. |. |||..|.  .. | ..|. | ||.  .| .. ..|.. |..|..||.. |||.....|.| .
WqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..er.esgetreveqlaytaWPdhGvPattkellefrk

AINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSE-NRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDI
........|.  |.|.||||||||||| |||| .......| ...|.. .|. ||..|. ||| . |. |.| |||. .
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0040439 (Phosphotyrosine protein) phosphatases II 526-758 1.8e-74 245.8 In-house 8-244 (249) alignment 
Range on Protein: 526-758
Range on HMM: 8-244/249.0
QEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDEVC
 . .. |||..|| ..||.||.|. .||...| ||||.||.|||  . .||||.| .||...||||.||..  .|||||. |       ..|||..... 
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsle

YGDIVVRADRNIELPNYVIRGFKVFNKrdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSK-ECGPVVVHCSAGVGRTGTIIALDIALEQ
|||..|.  . .....|..| ... |.    ...||.|...|. ||  .||   ...|||..|...|...  . |||.||||||||||||.||....|||
ygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleq

LKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
|. |..||.| .|| ||.|| ..|| . |..|.|.|.||
lekelgvdleeavkllrsqRpgavqnpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 530-758 4.1e-74 244.3 Pfam-A 2-235 (235) alignment 
Range on Protein: 530-758
Range on HMM: 2-235/235.0
HTKNRFKDIGAFDHTRVVLQETPGVPHshYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWP--SDDEVCYG
..|||.||| ..|.||| |....|     ||||||.||| ..| .|||| | |.|.. ||||||..|. .|||||.....      .|||  ..... ||
kkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DIVVRAD-RNI-ELPNYVIRGFKVFNkRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANdSKECGPVVVHCSAGVGRTGTIIALDIALEQL
|| |.   ..  .  .|..| ... . ... ...|.. |.|| .||...||......||..|.... . ... ||||||||||||||||..||||.||||
dikvelkekekedekeytlrklelkk.kkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
..|. ||.  ||| ||.|| .|||.| |..|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 530-758 4.1e-74 244.3 In-house 2-235 (235) alignment 
Range on Protein: 530-758
Range on HMM: 2-235/235.0
HTKNRFKDIGAFDHTRVVLQETPGVPHshYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWP--SDDEVCYG
..|||.||| ..|.||| |....|     ||||||.||| ..| .|||| | |.|.. ||||||..|. .|||||.....      .|||  ..... ||
kkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DIVVRAD-RNI-ELPNYVIRGFKVFNkRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANdSKECGPVVVHCSAGVGRTGTIIALDIALEQL
|| |.   ..  .  .|..| ... . ... ...|.. |.|| .||...||......||..|.... . ... ||||||||||||||||..||||.||||
dikvelkekekedekeytlrklelkk.kkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
..|. ||.  ||| ||.|| .|||.| |..|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 529-761 6.2e-74 243.4 In-house 9-243 (250) alignment 
Range on Protein: 529-761
Range on HMM: 9-243/250.0
DHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS----FKYWPSDDEVCYGDI
.. |||. || |.|..||||... |  .| |||| ...|| . |..|||| | ..|  .|||||.|.|. |||||||...|     .||| .    |||.
nkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdv

VVRADRNIELPNYVIRGFKVFNKRDrgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSEN
 |    . |  .|..| .|. ...   ..||.. |.|...||.| ||..|  ||.... ... ..  . .||.|.|||||||.|. ||.|  ||.|| |.
tvsllskeefadytkrklklskakk..aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

RVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
 ||.  ..||||..| ..|. | |.||.|...|. ..
vvdvfkvikvlrkdrphavesleqyvfvyeiilkald
0042113 (Phosphotyrosine protein) phosphatases II 528-758 8.4e-74 243.3 In-house 8-241 (245) alignment 
Range on Protein: 528-758
Range on HMM: 8-241/245.0
YDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDEVCYG
 ...|||..|| ..|||||.|....| ..| ||||.|..||.  . .||||.|..||...||||.||..  ||||||. ..     ...|||..... ||
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltyg

DIVVRADRNIELPNYVIRGFKVFNKrdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKS
|..|.  .   |..|..| ..| |.  . ...|.....||. ||  .||   ...|||......|  ... |||.||||||||||||.||....||||..
dftvtllseehlddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek

ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
| .|..| .|| ||.|| ..|| . |..|.| |.||
elgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 486-773 1.9e-72 239.0 In-house 7-296 (305) alignment 
Range on Protein: 486-773
Range on HMM: 7-296/305.0
TEFQEHVEQLNKNNQEMFKEIFESINSTspDYKCDatLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETC
 ........ ...... ... ..|. ..  . ..|  .  .| ...|||.|.|  .|. |. |.|.. ...|.||||.|..||   | ||..| | |.| 
ddlaayikearvysdkgleaqykslyee..eesid..vgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

DNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDE--VCYGDIVVRADRNIELPNYVIRGFKVFNKRDrGKKERTILQFHYITWPNKNVPAQASHVL
..|||...| |..||||||..|.       .|||      . .|...|    . . ..|..| .|. ....  |..||.||..  .||.. || .|. .|
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsll

DFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFS
.... .. .  . .  |..|||||||||||. ||.|||||.|| |. ||. ...| ||..| .|||.| |.||...|. | |  || | ... ..
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlr
0045098 (Phosphotyrosine protein) phosphatases II 528-758 2e-71 235.9 In-house 32-270 (278) alignment 
Range on Protein: 528-758
Range on HMM: 32-270/278.0
YDHTKNRFKDIGAFDHTRVVlqetpgvphsHYINANYIKGYydDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDEVCYG
 .  |||.||| ..||.||.           ||||.||.||  .| .||||.| ..|...||||.||... .|||||..|.      ..|||... . ||
gnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

DIVVRADRNIELPNYVIRGFKVFNK--RDRGKKERTILQFHYITWPNKNVPAQA--SHVLDFMRAINSAND------------SKECGPVVVHCSAGVGR
|..|.     .|..|..| ..| |   .. . ..|.. ..||..||  .|| .   ...|.... |..|..              . |||.|||||||||
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

TGTIIALDIALEQLksENRVDIEGIVKVLRQQRTQ-MVQELCQFVFIYNAVLE
|||..|... ||.|  |..||.. .|| ||.|| . .|| | |..|.| ..||
tGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_PTPN6_pd Subfamily PTPN6 484-758 7.5e-71 233.6 In-house 5-295 (306) alignment 
Range on Protein: 484-758
Range on HMM: 5-295/306.0
QRTEFQEHVEQLNKNNQEM----FKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQeTPGVPHSHYINANYIKGYY--DDKLYIAT
  .| ...|..|.|.....    |.| ||... .   .. . .  |.   ..|||.| |  ||||||.|.  |.|| | ||||||||.     || ||||
lakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiat

QYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDE-VCYGDIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVP
|   ..|  .||||||....  |||.|. |.       .|||.  |   ||.| |.  .. .| .|..| ..| .| ...|.||.. |.|. .||...||
qgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk.kkkkeerevfqyhfksWPdhgvp

AQASHVLDFMRAINSANDSKE---CGPVVVHCSAGVGRTGTIIALDIALEQLKS---ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
.. ..||||.. .|. ... |    ||.|||||||.|||||.| .|| |.....   .  .||. .||..|.|| ..||   |. |.|.|. .
kdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 518-780 1.1e-69 230.2 In-house 50-311 (319) alignment 
Range on Protein: 518-780
Range on HMM: 50-311/319.0
KCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVdSFKYWPSDD
 .| |    . .  |||. .| |||...| |. . |.  | |||| ...||   . |||.| | ..| ..||||.||... |||.||.     .||| . 
ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivlltkdk.csqywplki

EVCYGDIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINS-ANDSKECGPVVVHCSAGVGRTGTIIALDIA
.. ..   |. |   |  .||.| ... ..  . |  | | |||.  ||.. || ..| .. ... ..   .  ..  ..||||||||||||. |.||. 
vikeerfkvkvdsveetaeyvvrdielsed.gkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvl

LEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYIKSQ
|...| |..||.  .|. ||||| ..||.| |. ||| |.||. ..|     . .|  .. .  
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 527-781 2.2e-69 229.1 In-house 23-276 (284) alignment 
Range on Protein: 527-781
Range on HMM: 23-276/284.0
EYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVdSFKYWPSDDEVCYGDIVV
. .  |||. .| |||...| |. . |.  | |||| .|.||   . ||||| | ..| ..||||.||... |||.||.     .||| . .. ..   |
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltkdk.csqywplkivikeerfkv

RADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINS-ANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENR
. |   |  .||.| ... ..  . |. |.| |||.  ||.. || ..|... ... ..   .  ..  ..||||||||||||. |.||. |...| |..
kvdsveeseeyvvrdielsed.gkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekq

VDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHYIKSQE
||.  .|. |||||...||.|.|. ||| |.||. ..|     . .|  .. .  .
vdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsn
subfamily_PTPN12_pd Subfamily PTPN12 496-758 8e-69 226.7 In-house 3-275 (290) alignment 
Range on Protein: 496-758
Range on HMM: 3-275/290.0
NKNNQEMFKEIFESINSTSPDYKCDATL----MAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRM
.|...| |.. |... ..|  || ...       .|.. .|||.|||  .|..||.|... ....| |||||.||| .... |||.| |  .| |.||||
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

VWEQKTVTIVMLTNVVDSF-----KYWPSD--DEVCYGDIVVRADRNIELP-NYVIRGFKVFNKrdrgKKERTILQFHYITWPNKNVPAQASHVLDFMRA
.||...  .||. ..|.       .|||.   .|. .|.. |  ...  .  ...|| .|| ..    |..|.. ||||  ||...||..|...|.....
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssakslleliel

INSANDsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENR---VDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
... .. .|  |.||||||||||||||||.|.. |.||.|.    .|.  .|  ||.||. .||   |....|.||.|
vrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 492-776 3.4e-67 221.6 In-house 15-295 (315) alignment 
Range on Protein: 492-776
Range on HMM: 15-295/315.0
VEQLNKNNQEMFKEIFESINSTSPdYKCDatLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRM
| | . . .. ||. .|||      .  |     .  .. |||. .| |.|..|| |  .   |||.|.|||.|.||   . |||.| |  .. ..|||.
vaqkkastkngfkqdyesipggql.hpld..vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrl

VWEQKTVTIVMLTNVVDS-----FKYWPsDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKrdrgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINS
|.|..  .||||||.|.       |||| |..| || | |    .    .| .| . |  .    .. |...|.|| .||. .||. .  .....| .. 
vfeedigkivmltnlvegekrkaekywp.dkkviyGkitvtrkseevnteytvrtlsvvfg....dnirevvqlhytswpdmgvpkytiplmnlirtvkq

ANDSKEcGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHY
 ....  |..||||||||||||| |.||  |.|.. || .|.  ... .||.| .||| . |. |||.|.|| .| || |   | . ..|
hhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqry
0037934 (Phosphotyrosine protein) phosphatases II 526-758 6.7e-67 220.9 In-house 7-240 (243) alignment 
Range on Protein: 526-758
Range on HMM: 7-240/243.0
QEYDHTKNRFKDIGAFDHTRVVLqetpgvPHSHYINANYIKGYydDKlYIATQYPSKETCDN----FWRMVWEQKTVTIVMLTNVV-----DSFKYWPsd
 .....|||..|| ..||.||.|      . | |||||.|...  .. .||||.| .||...    ||||.||... .|||||. |     . ..|||  
lpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

DEVCYGDIVVRADRNIELPNYVIRGFKVFNkRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDS-------KECGPVVVHCSAGVGRTGT
.||.|||..|.     .|..|..| ... |  | .. .|.. ..||. ||  .||   ...|||......  ..       .. |||.||||||||||||
gevtygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

IIALDIALEQLksenRVDIEGIVKVLRQQRTQ-MVQELCQFVFIYNAVLE
.||... |..|    .||.| .|| ||.|| . .|| . |..|.| |.||
liaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 496-776 1e-63 210.2 In-house 12-292 (515) alignment 
Range on Protein: 496-776
Range on HMM: 12-292/515.0
NKNNQE-MFKEIFESINstSPDYKcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWE
|||..  .| | |  .    |.     |.  .| ...|||.|.|  .| .|| |.     ||| |.|| ||...  || |||.| | | . |.|||.|..
nknrhttlfseefhdlp..gpniy.pqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlq

QKTVTIVMLTNVVD--SF---KYWPS--DDEVCYGDIVVRADRNIELPNYVIRGFKVFnkrdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSA
... ||.|.|.  .       ||||    | | .| | |         . ..| ..|     .|.. ||. |||.  ||.| || ..| .| ..... . 
envttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl....kgddsrtvtqfhfteWPdkGvpkhtssllklikevkad

NDSKEcGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHY
..  .  |...|||||||||| .|..|  . . |  . ||.  .|...||.| ..||   |. |||.|||||. . .    .  |..| 
hgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 501-776 6.7e-63 207.4 In-house 19-293 (315) alignment 
Range on Protein: 501-776
Range on HMM: 19-293/315.0
EMFKEIFESInstsPDYKCDATLM-AQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVT
 .| | |  .    || .   .    .. ...|||.|.|  .|..||.|.     |.| |||| |||.. ||| |||.| | | . |.|||||...|. |
alfseefhdl....pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtt

IVMLTNVVDSFK-----YWPS--DDEVCYGDIVVRADRNIELPNYVIRGFkVFnkRdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKE
|||.|.  .. |     |||    | | .| | |         . |.| . |   | .... ||. ||..  ||.| |. |.| .| ..... . |..||
ivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt..r.kseesrtvtqfqftewPdkGvdkqtssllklikevkadngkke

cGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNHY
  ...||||||||||| .|..|  ..|.| .. ||.  .|| ||..| ..||   .. |||.|||||. . .   |.  |..| 
.fsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhl
subfamily_PTPN3_pd Subfamily PTPN3 506-758 1.4e-62 206.2 In-house 20-273 (280) alignment 
Range on Protein: 506-758
Range on HMM: 20-273/280.0
IFESINSTSPDYKCDATLMAQEydHTKNRFKDIGAFDHTRVVLQETPgvphSHYINANYIKGYYDD----KLYIATQYPSKETCDNFWRMVWEQKTVTIV
 || .    |. ...|. ....   .|||..|| ..|.||| |.|..    . ||||||..   .     . ||||| | ..|. .||.||||||. .||
qfeqlyrkkpglaisaarkpen..lsknryrdilpydatrvklkese....tdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLTNVVDS-----FKYWPSD-DEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDrgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKEcGP
|||..|..      .|||.  ||. ||.. |.  .. |  .||.| . . .|.   |.||.|||. |. ||...|| .....|.|.. ....  .||  |
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdket..keerkilqlqylaWpdhgvPddsadflefvervrklrsgke.eP

VVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
||||||||.|||| .|.|..||  . ... | .  ||. .|.||. .||   |. |. .|.|.
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_PTPN9_pd Subfamily PTPN9 489-758 2e-62 205.9 In-house 4-288 (297) alignment 
Range on Protein: 489-758
Range on HMM: 4-288/297.0
QEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMaqEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNF
.| |. .......  .. .. | ....  . .|. .    . .|||..|.  .|.|||||..... ..| |||||.. ||   | .|||| | |.|...|
eelvayvkekgkrGlskeyaeirnepveGtflaskl..ranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMVWEQKTVTIVMLTNVVDS-----FKYWPS--DDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDrgKKERTILQFHYITWPNKNVPAQASHVLDFM
|||||||....||| | ||.       .|||.  ..   .||. |.     |  .|..| ... | ..  ...|..  | ...||.  || .|. .||..
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt..eesrkvthfqflsWPdyGvPssaaslldvl

RAINSAND------------SKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
... ..                .  |.|||||||.||||| |.|||.|..|.... ||.   || ||.||. ..|   |..| | ||||
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 529-757 2.4e-61 202.2 In-house 28-265 (274) alignment 
Range on Protein: 529-757
Range on HMM: 28-265/274.0
DHTKNRFKDIGAFDHTRVVL-QETPGVPHSHYINANYIKGY-YDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSFK-----YWPSDDEV--
 .||||.|.|   ...||.| .|..  . |.|||||||||| ...| |.||| |  .| ..||||......  |||||.. .. .     |.| . ..  
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

--CYGDIVVRADRNIELPNYVIRGFKVFNKRDrgkkERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDS--KECGPVVVHCSAGVGRTGTIIALDI
   |||. .. .  .|  .| .| . . .  .    ||..  . |  ||....| .|...||... .......  ....|||||||||.||||  || .|
serygdveikvekiverndysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVL
|. ||. |. ||. .||  ||..|  |||.  |. .|..|. 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 487-785 1.7e-59 196.6 In-house 9-313 (325) alignment 
Range on Protein: 487-785
Range on HMM: 9-313/325.0
EFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAqeyDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCD
.. ||||. . ..|. |   |. . |  .  |  |.. .   .  |||||.. |.|..||||.     |.| ||||.|.. . . . ..|.| |  .| .
nlvehvekkkaqdqdgfahefgllpsddgiakkvamkpe...nkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

NFWRMV--WEqktVTIVMLTNVVDSF-----KYWPSD--DEVCYGDIVVRADRNIELPNYVIRGFKVfnKRDRGKKERTILQFHYITWP---NKNVPAQA
..||.|  |.    ..|...|..|       .||| .  . . .| . |.     |. .|| | ..|  |. .. . |.. ||.. .|.   ... ||  
dlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv..kqvkkGetrsvkqfqlqswddmGvqkrpatl

SHVLDFMRAINSA--NDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEF
  .|. . |..     ..|  .|..|||||||||||. |.|  ||...  | |||| | || ||..| .||.   |...||.|. | .. |.    .  |
isilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssf

SNHYIKSQEEATL
  .    ||   |
eaklsslqernpl
subfamily_CG7180_pd Subfamily CG7180 488-761 5.9e-58 190.8 In-house 5-291 (296) alignment 
Range on Protein: 488-761
Range on HMM: 5-291/296.0
FQEHVEQLNKnNQEMFKEIFESINStSPDYKCDATLMAQEYDhtKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDN
| . |.. .|  .  .| ... ..      .| . | ..  .  |||  ..  .|..||||..  |  .|.|||| |. ..  .| || |. | ||| |.
flklvdkrrk.frveyklelkltpr.leigdCagglrkenre..knrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvde

FWRMVWEQKTVTIVMLTNVVDSFK----YWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNK--------RDRGKKERTILQFHYITWPN-KNVPAQA
|||.|..... ..|.||.. |  |    ||| . .  ||.|.|   .. ...| .|| ||.  |        ..   ..|....|.. .|.  ..||  .
fWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlst

SHVLDFMRAINSAND----SKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
. .....| ...  .     .| |||||..| |..|.|  .|.|..||... |..||. . || ||..| |.|..  .. .||. .|| ..
nalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 527-758 6.1e-58 190.9 In-house 18-262 (270) alignment 
Range on Protein: 527-758
Range on HMM: 18-262/270.0
EYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYD-DKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDDEV-
  ... ||..||    .|||.|.|    ... ||||||..|. . .| |||.. | . |  .||||.||.|. .|||.|....       .|||.. .  
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

---CYGDIVVRADRNIELPNYVIRGFKVFnkrDRGKKERTIlQFHYITWPNKNVPAQAS------HVLDFMRAINSAN-DSKECGPVVVHCSAGVGRTGT
    .|.| |.|  .     |...  ..    ..|...| .  |.| |||.. || ..       ..|  .||.   . . .. .|..||||||||||||
vkledgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

IIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
.||||||.. |.....||.  |.. ||..|...||   |. |.|.||.|
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 515-766 7.8e-58 190.9 In-house 36-290 (297) alignment 
Range on Protein: 515-766
Range on HMM: 36-290/297.0
PDY-KCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDdkLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS----
|      .|   .  .  |.|.|.|  .|  || |. .   | | |.|| ..||.     .|.|| | |.| ..||.||..... |||||..  ..    
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkc

FKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVfnKRDRGKKERTILQFHYITWPNKNVPA--QASHVLDFMRAINSANDSKECGPVVVHCSAGVGRT
 .||. .  . .||..|      |   .. | ..|  .... |..| . |.... ||.|.|.   .|| .|...  ..   .... ||..|||.||||||
aryWsdkgvttfGdvsvvllsvsereGfikrelev..tkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrt

GTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMS
| ....|  . . | |. ||| |.|| |||.| ..||   |. |.|.|||| ..  |. 
gvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
subfamily_PTPN13_pd Subfamily PTPN13 499-758 1.4e-57 190.1 In-house 9-267 (273) alignment 
Range on Protein: 499-758
Range on HMM: 9-267/273.0
NQEMFKEIFESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLQETPGvphshYINANYIKGYYDDK--LYIATQYPSKETCDNFWRMVWEQK
.|.. .| |. ..   |  .|. .  ..  ...|||....  .|.||| |..  |     ||||..||   ...   |||.| |  ||...||.||||||
dqqqPaeefkelrelkpldtcevgkkke..nkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

TVTIVMLTNVVDS-----FKYWPSDDE---VCYGDIVVRADRNIELPNYVIRGFKVFNKRdrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSAN
.  |.|.|. ...      .|||.  .   . .. . |.  .  .| ..|.| ..| ...   .. | . ......||. .||..| ..| |.. ... .
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse..sgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq

DskECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
.  . ||.|||||||.||.||.|..|..|. .. .. .|.. ||. ||.||  .||   |..|.|.|.||
t..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 486-759 2.3e-56 185.8 In-house 5-282 (290) alignment 
Range on Protein: 486-759
Range on HMM: 5-282/290.0
TEFQEHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLQETPGVPH--SHYINANYIKGYYDDKLYIATQYPSKE
 .| |.|.. .....| |.. |....|.. ...    |  .  ....|||..|   |  |..|.. .| .    .|||| ||||| ..| ||||| | ..
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltss..nkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn

TCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgKKERTILQFHYITWPNKNVPAQASHVL
|  .||...|..|.  ||||||....      .|||. |   || . ..   . .| .|..| ..| ||.   ...... |..  .|...   .. . .|
tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtil

DFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLED
  .. ..  .  .  ...|||||..|||... .|....... |.|  .|.  ..| .|.|. ..||   |. .|.. ||. 
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 486-761 7.7e-56 184.2 In-house 5-279 (287) alignment 
Range on Protein: 486-761
Range on HMM: 5-279/287.0
TEFQEHVEQLNKNNQEMFKEIFESINS-TSPDYkcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQetpgVPHSHYINANYIKGYYDDKLYIATQYPSKET
 .| | |.. .....| ||. |  ... |  .   . |    . .. |||...|   |  ||.|.      |  |||| .|.|| ..| .|... |  .|
ekfgefvakghakgnegfknqftvleqvtqred..evthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnt

CDNFWRMVWEQKTVTIVMLTNVV-----DSFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKKeRTILQFHYITWPNKN-VPAQASHVL
  |||.......  .||||..         ..|||... |..|.  ..   .    .|..| ..| ||   |.| ... |... .|...  |. ... .|
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdk.qqvkqyqitnWdstgkvtepqtill

DFMRAINSANdSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
 . . . .    .  ...|||||..|||... .| ...... | |  .|.  ..|  |.|. ..||   |. ||...||| . 
vieemyktqr.krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_PTPN1_pd Subfamily PTPN1 498-762 8e-56 183.9 In-house 3-273 (290) alignment 
Range on Protein: 498-762
Range on HMM: 3-273/290.0
NNQEMFKEIFESINSTSPDYKCDATLMaqEYDHTKNRFKDIGAFDHTRVVLQETPGvphsHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKT
......|||.. |.  . |... .. .  . ....||..|.  .||.|..|...      .||||. ..    .. || || |  .|.| ||.||||||.
dkkrlykeiyldirkeasdfptreakl..penrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqks

VTIVMLTNVVD-----SFKYWPSDDE---VCYGDI--VVRADRNIELPNYVIRGFKVFNKRdrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAI-NS
 ..||| .||.      ..|||...|   . . |.   |.  .. .  .|..| ... |..   .. |.||.|||.|||.  ||   .  |.|.  . .|
kavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlk..tqetreilhfhyttwpdfgvpespaaflkflfkvres

ANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSEN---RVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVY
   |.. ||.|.|||||.||.||.. .|  | ... ..    |||.  .  ||..|. ..|   |. | | |.|| .  
GslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_PTPN14_pd Subfamily PTPN14 495-758 1.9e-55 183.0 In-house 16-294 (300) alignment 
Range on Protein: 495-758
Range on HMM: 16-294/300.0
LNK--NNQEMFKEiFESINSTSPDYKCDATLMaqEYDHTKNRFKDIGAFDHTRVVLQETPGVpHSHYINANYIKGYY--DDKLYIATQYPSKETCDNFWR
|.|  .. ..|.| .| |   . | ..... .  . .  ||||||.  ....|| |. |    .. ||||  ||      .. ||..| | . |. .||.
lekkleegkvfte.yeripkkredallstakl..penaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWq

MVWEQKTVTIVMLTNV-----VDSFKYWPSD----DEVCYGDIVVRADRNIELPNYVIRGFKVfnKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFM
|||||..  |||||.        ||||.|..    ..| .|   | .  . . . .. .|.|.  |    |.|||.. . |. ||...||   .. |...
mvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglkl..khlpskeertvwhlqytDWpdhgvPeDvkgflsyL

RAINSAN----DSK----ECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
. ..|      ...    .  ||.||||||||||| .|  |. .. |. ....||. ... ||.||  .|| |.|. |.|.....
eevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 530-758 1.5e-54 179.7 In-house 4-237 (237) alignment 
Range on Protein: 530-758
Range on HMM: 4-237/237.0
HTKNRFKDIGAFDHTRVVLQETPGVphSHYINANYIKGYYD-DKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDE-VCYG
. |||. .| |.||.||||. . .   | ||||.|.||.    | |||.| | . .||.||.|||..|   ||||| ...       ||||| |.  .||
kiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

DIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRA-INSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLK
 . |   .. |. .| .| . ....  . |. | | |... .||.. || |.. .| | .  || ..   |.|| ..|||||||||| .. .|  | | |
vltvslkkkeefsdytvrslllskr.ltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

SENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
 .. |||   |. . ..|  ..|   |.|||....||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 500-775 6.9e-54 177.7 In-house 19-251 (392) alignment 
Range on Protein: 500-775
Range on HMM: 19-251/392.0
QEMFKEIFESInsTSPDYKcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVT
  .| | |  .   .||   . |   .| .  |||.|.|  .| .||.|.    .|.| |.|| ||...  .| |||.| |   . |.|||||..... |
salffeefhdl..pgpdiy.pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvtt

IVMLTNVVDSFkywpsddevcygdivvradrnielpnyvirgfkvfnkrdRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAInSANDSKECGPVVVH
|.|.|.. .                                         .|.. ||. |||.  ||.|.|| ..| .| |.. . .|.  .   |...|
iamvtklkegd.......................................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliih

CSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMSTLIDEFSNH
||||||||| .|..|  . . |    ||.  .|  .|..|  |||   |. ||| |||||... .    .  |..|
csagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdh
subfamily_PTPRN_pd Subfamily PTPRN 497-760 1.4e-53 176.5 In-house 26-292 (297) alignment 
Range on Protein: 497-760
Range on HMM: 26-292/297.0
KNNQEMFKEiFESINSTSPDYKCDaTLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYY-DDKLYIATQYPSKETCDNFWRMVWEQ
||.. . || .|.. .   . ..  ..  .|   .||| |.. ..||.|| |.|.    .|.||||  |         ||||| |  .|  .||.|||||
knkdrleke.wealcayeaepstk.evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweq

KTVTIVMLTNVVD-----SFKYWPSDDEVCYGDIVVR-ADRNIELPNYVIRGFKVFNKRdrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSAND
 .| ||.||.. .       .||| . .  |.   |.     |   .|..| | . | .   .. ||. |||...||...|||.|  .|.| | .| .  
GvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlq..tsetrtvtqfhflswpeegvPasaksllefrrkvnksyr

SKECgPVVVHCSAGVGRTGTIIALDIALEQL-KSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDI
 . | |.|||||.|.||||. |..|. |..| |  ...||   .. ||.||...|.   || |.. || |..
Grsc.pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 494-758 6.4e-53 174.4 In-house 11-291 (301) alignment 
Range on Protein: 494-758
Range on HMM: 11-291/301.0
QLNKNNqemFKEIFESINSTSPDyKCdaTLMAQEYDHTKNRFKDIGAFDHTRVVLQETPG--VPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRM
. ..|.   |.| .......... .|  |.  .| ... ||||.|  .|. |..|...|   . . .||||.||.|| . | .||.| | |.|  .|||.
akhsnk...feeqykelkegedk.sc..tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrl

VWEQKTVTIVMLTNVVDS-----FKYWPS--DDEVCYGDIVVRADRNIELPNYVIRGFKVF-----N--------KRDRGKKERTILQFHYITWPNKNVP
.|..|.|.|||.||  ..     ..|||.   ..  .| . |    .  .|..||| ..|      |        | .. |. ...||.. . ||.  | 
iwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvv

AQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
 .   ||  .  .  .. . . ||||||||..|.|.|. ....|.||| |.|  ||. ...| .|...  .|. | |...||... .
reprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 507-757 6.6e-53 174.3 In-house 16-274 (287) alignment 
Range on Protein: 507-757
Range on HMM: 16-274/287.0
FESI------------------NstspdykcdatlmaqeydHTKNRFKDIGAFDHTRVVLQETPGVpHSHYINANYIKGYYDDKLYIATQYPSKETCDNF
.. .                  .                    |||. |.  .|.|||.| ...    | ||||||. .| ||. .||.| |   |  .|
vdalkedsesstatfkaaeelaa..................vkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdf

WRMVWEQKTVTIVMLTNVVD-----SFKYWPSDDEV--CYGDIVVRADRNIELPNYVIRGFKVFNKRdrGKKERTILQFHYITWPNKNVPAQ----ASHV
||.|.|... .....|  |.      .||||  .      |  ||  |..|  |.| .| ... .    ... | . |.....||.| ..      .  |
wravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidle..trearvvkqldllswPdkvlaPtavglirfv

LDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVL
||  . |. | |..| ||.|||...|.||.|...|. . ...|..  |||.  .|  ||..|. .||   |. ..|.|. 
ldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 529-758 2.5e-51 169.1 In-house 7-238 (239) alignment 
Range on Protein: 529-758
Range on HMM: 7-238/239.0
DHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYD-DKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPsDDEVCYG
...|||. .| ..||.||||..    ||| ||||.|.. |    | |||||   . .. .||||.|... . ||||| ... .     .||| |    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

DIVVRADRNIELPNYVIRGFKVFNKrDrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSaNDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKS
.. |   .   . .|.|| | . .      .|| . |.|.  ||.| ||  |. || . | |   .    . | |.||||||||||... .|  | | | 
nlrvtlrktevfadyiirtfvmsqv.g.qteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
.. |||   || .|..| .|||   |.|||. ||||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 529-758 3.9e-51 168.5 In-house 8-239 (239) alignment 
Range on Protein: 529-758
Range on HMM: 8-239/239.0
DHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYD-DKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPsDDEVCYG
...|||. .| ..||.||||..    ||| ||||.|.. |    | |||||   . .. .||||.|... . ||||| ... .     .||| |    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

DIVVRADRNIELPNYVIRGFKVFNKrDrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSaNDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKS
.. |   .   . .|.|| | . .      .|| . |.|.  ||.| ||  |. || . | |   .    . | |.||||||||||... .|  | | | 
nlrvtlrktevfadyiirtfvmsqv.g.qteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
.. |||   || .|..| .|||   |.|||. ||||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 495-766 7.9e-49 161.0 In-house 3-272 (283) alignment 
Range on Protein: 495-766
Range on HMM: 3-272/283.0
LNKNNQEMFKEIFESINStsPDYKCDATlmAQEYDHTKNRFKDIGAFDHTRVVLQETPGvphsHYINANYIK---GYYDDKLYIATQYPSKETCDNFWRM
|..||...|.| .. ..   || ..| .  . . ...|||...| . |  || |.  .     .|||| .|     | .|| ||..| | ..|  .||.|
lrvnnnklfrevlkrlsv..pdldadia..sadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkm

VWEQKTVTIVMLTNVVDSF-----KYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINS
|...| ..|||||.. .       .|||..  . ||.  |   ..     ..|. . . ..    |..  .  . .| | . .  |    .. | . |  
vfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn.ssakstlllahyqvidWleygeqaiinslvkfnkvisl

ANDSKeCGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMS
 ..||  ||.|||||.|.|||.. ||.  .......|  ||.  .||..|.||  .||.| |. .....|||. . ||  
qtesk.kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtq
subfamily_PTPN23_pd Subfamily PTPN23 490-759 1.2e-48 160.4 In-house 4-279 (288) alignment 
Range on Protein: 490-759
Range on HMM: 4-279/288.0
EHVEQLNKNNQEMFKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQetpgVPHSHYINANYIKGYYDD-KLYIATQYPSKETCDNF
|....   ...  ... |. ....      . .. . .   .|||..||  .||.||.|.      .  |||| ..|.       .|||| | ..|   |
eelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WRMVWEQKTVTIVMLTNVVDSFK-----YWPSD--DEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgkKERTILQFHYITWPNKNVPAQASHVLDFM
|.||.|||. .||||..  . .|     |||.|  . | .||. |   .. |....| | .|.  .. .  . ...   .. .||.  |||  ...|.|.
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad..avksvshlqltsWpelGvPasPetllqfl

RAINSA---NDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENR-VDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLED
 ...||   .  |   |.||||||||||||..  .  |...|. .|  .||  .|. ||.||  ||||  |. | |.|||| 
devesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0041856 (Phosphotyrosine protein) phosphatases II 530-763 5.2e-48 158.4 In-house 2-174 (182) alignment 
Range on Protein: 530-763
Range on HMM: 2-174/182.0
HTKNRFKDIGAFDHTRvvlqetpgvpHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTnvvdSFKYWPSDDevcygdivvrad
..|||..||  .||.|          ...|||||.. |.. .. .|||| | ..|. .|.||..|..  |||.||    .. |||..             
ldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywpell............

rnielpnyvirgfkvfnkrdrgkkERTILQFHYITWPNKNVPAqASHVLDFMRAINSandskECGPVVVHCSAGVGRTGTIIALDIALEQlksenRVDIE
                        ||...|..|. ||  .||   ...|||......     | |||.||||||||||||..|... ...     .|..|
........................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

GIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYG
 .|| .|..| .||. . |..|.. |.|| . ..
eavklvrsrRpgmvitpnqyfflqlallellllk
0051429 (Phosphotyrosine protein) phosphatases II 554-759 1.4e-47 157.9 In-house 1-224 (272) alignment 
Range on Protein: 554-759
Range on HMM: 1-224/272.0
VPHSHYINANYIKGYYD---DKLYIATQYPSKETCDNFWRMvWEQKTVTIVMLTNVV-----DSFKYWP------------SDDEVCYGDIVVRADRNIE
.| |.||||....||.    .........|.. |...|||. .|..  |||.|....     . ..|||            |. .. ||...|.    . 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LPNYVIRGFKVFNKRDRGKKeRTILQFHYITWPNKNVPAQAshVLDFMRAINSandskeCGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVD------
|..|..| . . .. . |.  |.....||. ||  .|| .|  .|........       |||.||||||..||||..||.. |...  |  ||      
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--IEGIVKVLRQQRTQMVQELCQFVFIYNAVLED
  .|..|. ||.|| ..||   |..|.|.|.|| 
lyleeaveelraqrpgavqteeqylflyeallel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 487-758 1.2e-43 143.8 In-house 13-281 (290) alignment 
Range on Protein: 487-758
Range on HMM: 13-281/290.0
EFQEHVE-QLNKNNQEMFKEIFESINSTSPDYKCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQEtpGVPhSHYINANYIKGYydDKLYIATQYPSKETC
 |..      .|| .|. || .| .    |    .  .. .. . .|||.||.   | |||.|..  | .   |. |||.||   .  .| || . |.| 
afekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd..Gyd.GdyvhanyvkGl..kamfiltqGalkdtv

DNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPSDD--EVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKkERTILQFHYITWPNKNVPAQASHVL
 ..|||| ..|. .|||| ....       .|.|  .   . .|.| |    . .  . .|.      ..| || |  .  .. ..||.| |.  .  .|
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGk.ehklkhlkikswpdksvalstlall

DFMRAINsandsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
  .|..      |  ||||||||||.|||||..|....|. |     .|. ..|. ||. | . ||   |.. . ...|.
rtlrilr.....kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
0049772 (Phosphotyrosine protein) phosphatases II 528-758 1.4e-43 145.2 In-house 45-278 (314) alignment 
Range on Protein: 528-758
Range on HMM: 45-278/314.0
YDHTKNRFKDIGAFDhTRVVLqETPGVPHSHYINANYIKGYyddKLYIATQYPSKETCDNF----------WRMV--WEQKTVTIVM-------------
  ..|||..||  .| .||.|  . .|  | ||||.|..|.   . .||||.|...|...|          ||||  ..... .|||             
lnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------LTNVVDSFKYWPSDDEVCYGdivvradrnielpnY-------VirgfkvfnkrdrgkkERTILQFHYITWPNKNVPaQASHVLDFMRAINSA
        |...   . ...  |   .                       .               ||.......| .|  ..|   .....|...|..|
daAlgKtpllildgngneptaadlellk..............eelydpelf...............erlgikylripvpDgsap.lledfdeflefieea

ndsKECGPVVVHCSAGVGRTGTIIALDIALEQLksenRVDIEGIVKVLRQQRT-----QMVQELCQFVFIYNAVLE
   .. |||.|||.||.||||| ..... . .|    .|..| ... .|..|.      ... |.|..||..|.||
...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealle
0043147 (Phosphotyrosine protein) phosphatases II 555-753 3.3e-42 139.5 In-house 3-154 (172) alignment 
Range on Protein: 555-753
Range on HMM: 3-154/172.0
PHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVvdsfkywpsddevcygdivvradrnielpnyvirgfkvfnKRDRGKKE
..|.||||.|...||  . .||||.|  .|.. ||||..|..  .||.||.                                           |. . |
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpelle

RTILQFHYITWPNKNVPaQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALeqlkseNRVDIEGIVKVLRQQRTQMVQELCQFVFIY
|...|..|. ||  .||  ....|.|.. |...   .. |||.||||||||||||..|... |       ....| .|. .|..| ..||   |  |.|
rlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly
0036282 (Phosphotyrosine protein) phosphatases II 557-753 3.3e-42 139.5 In-house 2-163 (174) alignment 
Range on Protein: 557-753
Range on HMM: 2-163/174.0
SHYINANYIKGYYDDKLYIATQYPSKetcdnFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSddevcygdivvradrnielpnyvirgfkvfnkrDRG
|.||||......|  . .||.|.| .     ||.|..|..  |.|||.. .       . |||.                                 .| 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

KKERTILQFHYITWPNKNVPAQAShVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKsENRVDIEGIVKVLRQQRTQMVQELCQFVF
  ||...|..|. ||  .||  .  .|.|......|  ... |||.||||||||||||..|... | .|. |. ||.  .|. ||.|| .|||   |. |
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IY
.|
ly
0046846 (Phosphotyrosine protein) phosphatases II 548-757 1.3e-38 127.8 In-house 3-170 (176) alignment 
Range on Protein: 548-757
Range on HMM: 3-170/176.0
LQETPGVPHSHYINANYIKGYYddklYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDEVCYgdivvradrnielpnyvirgf
|...   ....|||||.| |..    .||||.|  .|. .|..|..|..  ..|.||. |.      . |||   .. .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kvfnkrdrgkkertilQFHYITWPNKNVPAQaSHVLDFMRAINSANDSKecGPVVVHCSAGVGRTGTIIALDialeQLKSENRVDIEGIVKVLRQQRT-Q
                |.... ||  .||   ...|.....|..| ...  |||.||||||.|||||..|..     |..|. ...| ... .|.||  .
................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplg

MVQELCQFVFIYNAVL
.||  .|  |.| ..|
avqtpeQyrflyefel
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 498-758 4.4e-37 122.5 In-house 3-257 (267) alignment 
Range on Protein: 498-758
Range on HMM: 3-257/267.0
NNQEMFKEIFESINSTSPDYKCDATLMAQEYdHTKNRFKDIGAFDHTRVVLQETPGVphshYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKT
...  ... || |.  |..    .. .|..  . .||. |   .|.|||.|...       |||| |..||.  . .|.|| | | |  .|. .. .|| 
deeceiekefelikkisdtsstisqsiaekn.qernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkv

VTIVMLTNVV-DS-FKYWPSD--DEVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGkkeRTILQFHYITWpnkNVPAQASHVLDFMRAINSANDSKEC
 .||.||.|  |   ..||    .   | |..|    . |  .| |  ...  | .     . .  ..|  |   |. ..    |  . .| . |. .. 
pvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa...hnvtlyyykkw...nintnnkpylkplfgilaknqleng

-GPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
  |.||.||.||||.|| . .|  ||..| |. .||   .. .|.||  .|. . ....|.. . |
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 495-758 3.1e-36 119.9 In-house 11-275 (307) alignment 
Range on Protein: 495-758
Range on HMM: 11-275/307.0
LNKNNQEMFKEiFESINSTSPDykcDATLMAQEYDHTKNRFKDIGAFDHTRVVLQeTPGVpHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWE
|.|  |..  | |. .   .|.     |  | . .  |||..|. . |..|.|.. ..|.  | || |||.    . | .|..| | ..|  .|| |. .
ldkgvqalvde.frvlakktpe...gvtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiq

QKTVTIVMLTNVVDS-----FKYWPSDDEvcYGDIVVRADRNIELPNYVIRGFK-------VFN-KRDRGKKERTILQFHYITWPNKNVPAQASHVLDFM
.|  ...|| .|..       .||| ..      . . | . | . |  .. .        | . | | ..| ||| .. .  ||.. ||      ....
ekvesvimlckvielakikceqywpleeg..qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll

RAINSandskECGPVVVHCSAGVGRTGTIIALDIALEQ-LKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
 |..      .  ||||||||||||.|||.|. .  .. .. .|  |.. .|. ||.||   .|.  |.....  .||
eavry.....dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 500-758 4.1e-36 119.1 In-house 10-267 (281) alignment 
Range on Protein: 500-758
Range on HMM: 10-267/281.0
QEMFKEIFESINSTSPDYKCdaTLMAQEYDHTKNRFKDIGAFDHTRVVLQE-TPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTV
 . ||. |  .    |   |  | . |  .  |||. .| ..| .|| |.   |    . || ||||.  .  . || || | |||  .||||.|...| 
lddfkqefsnlpgdppsdlc..tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqentt

TIVMLTNVVD-----SFKYWPSDDEVCYGDIVVRADRNIELPNYVIRGFKvFNKRDRGkKERTILQFHYITWPNKNVPAQASHVLDFMRAINSandskEC
.|||| ....       .|.| .  .|     .  . .    |  .   . .|    | . | | .. .  ||. .||  .  .|  .| | .       
aivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr.lnlsyeg.etrlithwlwkewpdwqvpessevmlkilrkira.....rs

GPVVVHCSAGVGRTGTIIALDIALEQLKSENR-VDIEGIVKVLRQ-QRTQMVQELCQFVFIYNAVLE
 | |.||||||||.||..|..|||. ..|     ||. ||  ||   |.  || | |...|.. .|.
tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0049260 (Phosphotyrosine protein) phosphatases II 564-754 1.6e-35 117.4 In-house 1-144 (152) alignment 
Range on Protein: 564-754
Range on HMM: 1-144/152.0
YIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWpsddevcygdivvradrnielpnyvirgfkvfnkrdrgkkertil
.|.||.  . .||||.|  .|...||||..|..  ||||||. ..       .|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QFHYITWPNKNVPAQASHVLDFMRAINSAnDSKECGPVVVHCSAGVGRTGTIIALDIALeqlkseNRVDIEGIVKVLRQQRTQMVQELCQFVFIYN
|.... ||  .||  . ..|.....|. .   .. |||.||||||||||||..|... |      ..|..| .|. .|..| ..|.   |  |.|.
qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
PTPc_DSPc_SM00012 657-758 2.8e-35 116.0 In-house 2-105 (105) alignment 
Range on Protein: 657-758
Range on HMM: 2-105/105.0
ILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKE-CGPVVVHCSAGVGRTGTIIALDIALEQLKSE-NRVDIEGIVKVLRQQRTQMVQELCQFVFIYN
. ..|| .||...|| .....|...||... .  .|  .|||||||||||||||..||||.|.||..| ..|||. ||| ||.|| .|||.. |..|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
0044763 (Phosphotyrosine protein) phosphatases II 541-755 6.4e-35 115.7 In-house 2-166 (178) alignment 
Range on Protein: 541-755
Range on HMM: 2-166/178.0
FDHTRVVLQETPGVPHSHYINANYIKGYyddkLYIATQYPsketcDNFWRMVWEQKTVTIVMLTNV-----VDSFKYWPSDDEvcygdivvradrnielp
.|.|||.|.. .|.. | ||||..| ..    ||.....|      .......|..  .||.||.      .....|||.. .                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

nyvirgfkvfnkrdrgkkertiLQFHYITWPNKNVPAQASHVLDFMRAINSANDsK-EcGPVVVHCSAGVGRTGTIIALDIALEQlksenRVDIEGIVKV
                      .|...| .|  .||   .|.|.|...|..| | . . |||.|||||||||.||..|... ...     ....| ... 
......................iqylhipipDhgvpdllehflefvefieeald.ekg.gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

LRQQRTqMVQELCQFVFIYNA
.|..|  .|.   |  ..|  
vrerRp.ivpnpgqlrqLyef
0051082 (Phosphotyrosine protein) phosphatases II 555-757 2.5e-34 113.4 In-house 1-150 (151) alignment 
Range on Protein: 555-757
Range on HMM: 1-150/151.0
PHSHYINANYIKGYyddklYIATQYPSKetcdNFWRMVWEQKTVTIVMLTNVV---DSFKYWPSDDevcygdivvradrnielpnyvirgfkvfnkrdrg
|.|.|||..|. |.     ......|.      |.....|..  |||.|.. .      .|.|. .                                  
plsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg..................................

kkeRTILQFHYITWPNKNVPAQASHVLDFMRAINSandsKECGPVVVHCSAGVGRTGTIIALDIALEQlksenrVDIEGIVKVLRQQRTQMVQELCQFVF
   ...|..... ||. ..|     ||.|......    |. |||.||||||.|||||..||.. |..      |..| ... .|..|. .||   ||.|
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

IYNAVL
.. |.|
qlfall
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 513-758 1.7e-32 107.3 In-house 37-287 (305) alignment 
Range on Protein: 513-758
Range on HMM: 37-287/305.0
TSPDYKCDATLM--AQEYDHTKNRFKDIGAFDHTRVVLQETPgvpHSHYINANYIKG-YYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS
| ||    |     . . . ||||..|. . |.. | |.. .    |.|| |||.      .| .|..| |  .| |.|| || ..|   |||| . |. 
trpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvel

F-----KYWPSD---DEVCYGDIVVRA-DRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANdskecGPVVVHC
      .|||          . |||     .  .         ..|    |... .. ....  ||.. ||      |... ||  ..      |.||||
gklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhc

SAGVGRTGTIIALDIALEQLKSENRV-DIEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
|||.||||||.|..  ||..  ....  .  .|| ||.||.  .|.  |..||.  .|.
sagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0047943 (Phosphotyrosine protein) phosphatases II 807-1022 1.5e-28 95.4 In-house 53-271 (273) alignment 
Range on Protein: 807-1022
Range on HMM: 53-271/273.0
SVVPFDYGEETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFGTT-GLKFGAITISVGRKKEfNAGFL
| |  . |.  .  | |.|||.... ||    |.....| |||.. ......|. | ... .     . | .. | .  |..| .|. . . .. .... 
srvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddyt

TRDINIRNEEDSMLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVESCHHGnHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYL
.| . ..| ...  . |....| .    |. |  .. ...||...  . |..... .|.. |  .  |  | |..| ..|.. .||. ...|.| ..   
vrtleltnlgtgesrtvthfhytgwp.dhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrs

QSPGLIVNLQFYAYCYDCLMEY
| || . ....| ..|..|.||
qRpgmvqtpeqyrflyealley
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 528-766 4.8e-28 93.0 In-house 42-277 (288) alignment 
Range on Protein: 528-766
Range on HMM: 42-277/288.0
YDHTKNRFKDIGAFDHTRVVLQETPgvphSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSD--DEVC
 . |..|....   | ||| |.. |      ||.|| .     ..  | .| | . | ...|.|. |.    ||||.....     | .|.||   ... 
anptrdryenlprcditrvklsddp....dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGDIVVRADRNIELPNYVIRGFKVFNKRDrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAInsandSKECGPVVVHCSAGVGRTGTIIALDIALEQL
.| .     .. .  . ...   . ...  |...  . . |.  |... || .    | ..  .      .   |.|||.|||||||||.|   ||||.|
igrlctvvkkkradidklvkvsllriske.geekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialesl

KSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDMS
.... . |. ... ||..| . .|   |.....  |||....    
rlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkyk
0040439 (Phosphotyrosine protein) phosphatases II 817-1023 6.1e-28 93.5 In-house 40-246 (249) alignment 
Range on Protein: 817-1023
Range on HMM: 40-246/249.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD----ADTYSYISEfgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNEED
 .  | |.|||. .. ||   .|... .| |||.. . ....|..|....     . . | ..   . |..| .|. . . .. .... .| . . | .|
dyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtllsvev.kddytvrtleltnlyd

SMLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESChHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFY
.  ..|. ||| |.   .. | .. ...||....  .|.. . ..|.| |  .  |  |.|... ..|.. .||. .....| ..   | || . |...|
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqy

AYCYDCLMEYS
 ..|..|.|. 
rflyeallell
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 651-775 8.2e-28 91.9 In-house 85-209 (440) alignment 
Range on Protein: 651-775
Range on HMM: 85-209/440.0
GKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFV
| . ||. |.||  ||.| ||  |. || ... .| ...    ||..||||||.|||| |||.|  | . |  ...||  ... .|..| ||||   |..
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FIYNAVLEDIVYGDMSTLIDEFSNH
|...|||| .. ||   | |. ...
fvheavlegllcgdtliledditer
0039614 (Phosphotyrosine protein) phosphatases II 786-1026 1.5e-27 92.3 In-house 34-292 (297) alignment 
Range on Protein: 786-1026
Range on HMM: 34-292/297.0
ITDEFNKIGAVKPPAQSYSGPS---------VVPFDY------------GEETMFTAHYLDGYWT-PNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLS
.  || ..  .||.   .  |          ..|.|.             . .   | |.|||.  .. || .  |.....| |||.. . ....|..| 
lllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLt

PTDAD---TYSYISEFGTtglKFGAITISVGRKKEfNAGFLTRDINIRNeeDSMLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVESChHGNHPI
... .    ..| .| |.   ..| .|. . . .. ..|. .| ....|  ..  . |. .|| ..   |. |  .. ...|....  ..... ....|.
klvelgrkcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwp.dhgvppslellleflelvrealael.pkggpv

LMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEYSNKL
| |  .  |  | |... ..|.. .||. ...|.| ..   | || . ....| ..||.|.|. .. 
lVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0040438 (Phosphotyrosine protein) phosphatases II 819-1039 1.6e-27 92.1 In-house 74-292 (317) alignment 
Range on Protein: 819-1039
Range on HMM: 74-292/317.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEfgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNEEDSM
  | | ||.. .. ||    |... .| |||.. . ....|..| ... .     . | ..   . |..| .|. .   .| .||.  | . . . .|| 
InAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdse

LLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVEschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAY
 ..|. ..| .    .. |  | . .|....  . |   ....|.| |  .  |  | |... ..|.. .||. ... .| ..   | || . ....| .
srtvthfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrf

CYDCLMEYSNKLLKEEYFPSIHENI
.||.|.|| .. |. |.... .  .
lydalleylkrkltlepaselklkl
0051299 (Phosphotyrosine protein) phosphatases II 780-1022 1.7e-27 92.0 In-house 19-285 (288) alignment 
Range on Protein: 780-1022
Range on HMM: 19-285/288.0
QEEATLITDEFNKIGAVKPPAQSYSG-----------PSVVPFDY-----------GEETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCS
.   |.. .||... ...|. . ...           ....|.|.           .. .   | |.|||.... ||    |.....| |||.. .....
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

HIINLSPTD----ADTYSYISEfgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNE----EDSMLLRVKYIQYQDMFlKHCFPR-VDKFMKFIQYCLVQ
.|. | ...     . . | ..   . |..| ||.   . .. .... .| . ..|      |.  ..|. ..| .    |..|  .. ...|....  .
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspellldflrlvrka

VEschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEY
 .   .|..|.. |     |  | |..| ..|.. .||. ...|.| ..   | ||.. ... | ..|..|.||
la...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 520-755 2e-27 90.6 In-house 41-285 (310) alignment 
Range on Protein: 520-755
Range on HMM: 41-285/310.0
DATLMAQEY--DHTKNRFKDIGAFDHTRVVLQETpGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKY
|..|  . |     |||. |.   | .|| |.      .  || |||.|  |  . .| .| | . |  .||||...... .|..| .|..        |
dssltyeaykkymhknrysdvvcldtsrvklkid.ksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPSDD-EVCYGDIVVR----ADRNIELPNYVIRGFKVFNKRDR---GKKERTILQFHYITWPNKNVPAQASHVLDfMRAINSAndskECGPVVVHCSAGV
|||      || | |     .  ..|. |  .         |      ||  .   ..  ||.. || .  | .   | .         ||.|||||||.
wpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrllaqv....rhgpcvvhcsagk

GRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNA
.|.....||......|.  ..||.| ..  |...|.. .|   |...|   
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_ptpA1_pd Subfamily ptpA1 522-720 2.3e-27 90.8 In-house 40-256 (418) alignment 
Range on Protein: 522-720
Range on HMM: 40-256/418.0
TLMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDdKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNV-----VDSFKYWPSD
.   .... .|||. .|   .|||| |..      | ||||||| | |  | .|.|| |  .|  .|||||||..   ||||.       .   .||| .
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

----DEVCYGDI-VVRADRNIELPNYVI---RGFKVFNKRDR-GKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSAN-----DSKECGPVVVHCSA
    .   ||.   |    ..|| . .    |     | |     . | | |..|  ||..|.| ..  . .....|   .      |    |..|||||
iggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsa

GVGRTGTIIALDIALEQL
|||||||. .  | ...|
gvgrtgtfctavimmkkl
0036941 (Phosphotyrosine protein) phosphatases II 812-1026 4.6e-27 90.5 In-house 59-280 (297) alignment 
Range on Protein: 812-1026
Range on HMM: 59-280/297.0
DYGEETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFGTTGLKFGAITISVGRKKEF-NAGFLTRDIN
| ..   . | |.|||. .. ||    |.....| |||.. . ....|..|.. . .     ..| ..     |..| .|. . . ... .... .| . 
ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtle

IRNEEDSMLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVeSCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAK---KERIINILQAANHHYLQSP
. . ...  ..|....| .    .. . .. ...||.... .  .   ...|.| |  .  |  | |... ..||. .   ||. ..||.| ..   | |
vtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRp

GLIVNLQFYAYCYDCLMEYSNKL
| . .|..| ..|..|.|. .| 
gavqtleqyrflyeallellkkk
0046845 (Phosphotyrosine protein) phosphatases II 818-1026 7.6e-27 89.8 In-house 59-277 (284) alignment 
Range on Protein: 818-1026
Range on HMM: 59-277/284.0
MFTAHYLDGY-----WTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFgTTGLKFGAITISVGRKKEfNAGFLTRDINIR
 . | |.|||     .... ||    |.....| |||.. ......|. | ... .     . | ..   . |..| .|. . .... . .. .| . ..
YinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtlelt

NEE-DSMLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVEScHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKER---IINILQAANHHYLQSP
|.. ..  ..|....| .    |. |  .. ...|....  . |. ..|..||. |. .  |  | |..| ..|.. .||.    ...|.| ..   | |
nlgytgesrtvthfhytswp.dhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp

GLIVNLQFYAYCYDCLMEYSNKL
| . .|. | ..|..|.|| ...
gmvqtleqyrfvyealleylklk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 520-761 9.5e-27 88.7 In-house 26-271 (285) alignment 
Range on Protein: 520-761
Range on HMM: 26-271/285.0
DATLMAQEYDHTKNRFKDIGAFDHTRVVLQETpgvpHSHYINANYIKGY-YDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYW
..|  | | .   ||. |. . . |||||..        || |....    |.  ||.|| |  ||  .||.|....|   ..||  ...        |.
nctytayeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PSD--DEVCYGD--IVVRADRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDsKEcGPVVVHCSAGVGRTGT
|    . | .|   | .   ..  .   ..  . | |  |   .   . . .   ||..  | .|  .... . ..  |  ||  |..|||||||||| |
peklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.ke.kpicvhcsagvgrtat

IIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
.. .| |  ..  .  ...  ||. .|  | | ||   ||.|.|  ..| ..
fvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
0043336 (Phosphotyrosine protein) phosphatases II 816-1022 1e-26 89.5 In-house 73-276 (278) alignment 
Range on Protein: 816-1022
Range on HMM: 73-276/278.0
ETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD----ADTYSYISefgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNEE
 .   | |.|||. |. || .  |.....| |||.. . ....|..| . .       . | .    . |..| .|. . . .. .... .|.... |  
sdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlg

DSMLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVEschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQ
|.  . |  ..| ..   |..|  .. ...|... . ..|   . |.|.| |  .  |  | |..| ..|....||. .....| ..   | || . ...
dgesrtvthyhylgwp.dhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtps

FYAYCYDCLMEY
.| ..|..|.||
qyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 817-1022 1.9e-26 89.0 In-house 93-303 (307) alignment 
Range on Protein: 817-1022
Range on HMM: 93-303/307.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNE-E
...   .||||. .. ||    |.... | |||.. ......|..|.... .     . | ..   . | .| .|. . ....  .|.  | ... .  .
rvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldg

DSMLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESChHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERI---INILQAANHHYLQSPGLIVN
... ..|....| .    .. | .. . .||....  .|..  ...|.| |  .  |  | |... ..|.. .|| .   ...|.| ..   | || . |
tgesrtvthfhytgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqn

LQFYAYCYDCLMEY
...| ..|..|.|.
peqyrflyeallel
subfamily_egg_pd Subfamily egg 523-765 5.2e-26 86.0 In-house 34-277 (307) alignment 
Range on Protein: 523-765
Range on HMM: 34-277/307.0
LMAQEYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSFK---YWPSD--D
  |..   .| | | .   | .|| |.   |     .| ||..||      .| .| | |.| |.|||||....   |||||  ..| .   |||    |
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesd

EVCY--GDIVVRADRNIE--LPNYVIRGFKVFNKRdrgkKERTILQFHyiTWPNKNVpAQASHVLDFMRAINSAndSKecgPVVVHCSAGVGRTGTIIAL
 . .  | . . . .  .   | . .  .|.        .|   |.     .  .|. ..    |  .| .  .  ||   ||||..  || ...|..|.
slvtvpGslrienlkvdskadplfrvtklklvGgd....deerflehw..qgdvnns.sdvysplrvlrklrnl..sk...pvvvqdilGvskaatlvai

DIALEQLKS--ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVL---EDIVyGDM
.||| .|      .  .   |. ||..|   |.   ...|.|  ||    |.. |  
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi.gsa
0050432 (Phosphotyrosine protein) phosphatases II 773-1027 7.3e-26 86.6 In-house 32-303 (308) alignment 
Range on Protein: 773-1027
Range on HMM: 32-303/308.0
SNHYIKsQEEATLITDEFNKIGAVKPPAQSYSGP-----------SVVPFDY------GEETMFTAHYLDGY--WTPNLFIKSPCPTKDNTECFWRLIIH
 ... | . . .|.  ||... .|||. . ...            ...|.|.      .. .   | | |||  . |. ||    |.....| |||.. .
lkllek.aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

KKCSHIINLSPTDADT----YSYISEFGT-TGLKFGAITISVGRKKEfNAGFLTRDINIRNEEDSMLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLV
 ....|. |  .. .     . |  .    . |..| .|. . . .. .... .| . ..| .|.  ..|. ..| .    |. |  .. ...|....  
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWp.dhgvPpspeilldflelvrk

QVeschhGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEYSNKLL
.      ...||. |     |  | |..| ..|.. .||. .....| ..   | || . ... | ..|..|.|| ...|
sl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 502-752 1.4e-25 84.6 In-house 24-273 (301) alignment 
Range on Protein: 502-752
Range on HMM: 24-273/301.0
MFKEIFESINSTSPDyKCDATLMAQEYDHTKNRFKDIGAFDHTRV-VLQETPGVPhshyINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTI
...  .|..| |. | | . |       . |.|.. .    .| | |...   ||    | ||.|.   . . .|||| | |.|...|| |.   .  .|
fynttienvnvttid.kdhitesyaylpkdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydveki

VMLTNVVDSF-----KYWPSDD----EVCYGDIVVRADRNIELPNYVIRGFKVFNKRDRgKKERTILQFHYITWPNKNVPAQASHVLDFMRAINsanDSK
|||.. |.       .| |..     ..   .| ..    |   . . | ..| .  ..  . ||.. . | .|....||    .. |.|  .    .|.
vmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk.fatrtvthyqysewtdrgvPkshaelfdlmelvk...kse

EcgPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFI
.  |.|||||||.||. . |. ..   ..........   .| ||..| . ||   |. ..
k..PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
0042113 (Phosphotyrosine protein) phosphatases II 818-1023 1.5e-25 85.5 In-house 39-243 (245) alignment 
Range on Protein: 818-1023
Range on HMM: 39-243/245.0
MFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD----ADTYSYISEfgTTGLKFGAITISVGRKKEfNAGFLTRDINIRNEEDS
   | | |||. .. || . .|.....| |||.. . ....|..|....     . . | ..   . |..| .|. . . .  .... .| ... |. |.
yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtllseeh.lddytvrtlevtnlgdd

MLLRVKYIQYQDMFlKHCFPR-VDKFMKFIQYCLVQVESchHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFY
  . |  ..| ..   |. |  .. . .|..... ....  ..|.|.| |  .  |  | |... ..|....||. ... .|  .   | || . ....|
esrevihyhylpwp.dhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqy

AYCYDCLMEYS
 ..|..|.|. 
rflyeallell
0048076 (Phosphotyrosine protein) phosphatases II 644-756 1.7e-25 84.8 In-house 36-139 (145) alignment 
Range on Protein: 644-756
Range on HMM: 36-139/145.0
VfnKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKecGPVVVHCSAGVGRTGTIIALDIALEqlkseNRVDIEGIVKVLRQQRTQMV
.   ...   ||...|..|. ||  .||  ....|.|...|..| ...  |||.||||||||||||..|... |.     ..|..| ... .|.|| ..|
l..tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgav

QELCQFVFIYNAV
.   |. |.| ..
pnpgqlrflyefe
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 782-871 2.9e-25 83.6 In-house 18-130 (439) alignment 
Range on Protein: 782-871
Range on HMM: 18-130/439.0
EATLITDEFNKIGAVKPP--------AQSYSGP-----SVVPFDYGEETM-----------FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCS
.  .....|.||....|.        ||.|...     .|..||....|.           ..|.|..||....|.|....|.|..|..||||.|.||..
kqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktv

HIINLSPTdADTYS
.|..|.    ..| 
tivmltnl.vesyk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 571-754 7.3e-25 82.3 In-house 4-198 (199) alignment 
Range on Protein: 571-754
Range on HMM: 4-198/199.0
DKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVV-----DSFKYWPSDDE--VCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYI
.. |||||.| .||  .||.||||  .  |||. .       |   |||. .     || . | .      |.|.|  . . |.       | | .. . 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPNKNVPAQASHVlDFM---RAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKS--ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYN
.| .|  |  |  |  |.   | .    . .   ||.|||| | | || ..|||| .   .      ||.  . | ||| |  ..  | .. |||.
swkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 572-754 7.5e-25 82.3 In-house 4-197 (198) alignment 
Range on Protein: 572-754
Range on HMM: 4-197/198.0
KLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVV-----DSFKYWPSDDE--VCYGDIVVRADRNIELPNYVIRGFKVFNKRDRGKKERTILQFHYIT
. |||||.| .||  .||.||||  .  |||. .       |   |||. .     || . | .      |.|.|  . . |.       | | .. . .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPNKNVPAQASHVlDFM---RAINSANDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKS--ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYN
| .|  |  |  |  |.   | .    . .   ||.|||| | | || ..|||| .   .      ||.  . | ||| |  ..  | .. |||.
wkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0048179 (Phosphotyrosine protein) phosphatases II 645-754 1.7e-24 81.6 In-house 37-139 (144) alignment 
Range on Protein: 645-754
Range on HMM: 37-139/144.0
FNKRDRGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINSANDSKecGPVVVHCSAGVGRTGTIIALDIALeqlksENRVDIEGIVKVLRQQRTQMVQ
 ....    ||...|.... ||. .||  ....|.|...|..| ...  |||.||||||||||||..|... .     ......| ... .|..| ..|.
teeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavp

ELCQFVFIYN
   |. |...
npgqlrfLle
Y_phosphatase Protein-tyrosine phosphatase 819-1021 1.1e-23 79.3 Pfam-A 30-235 (235) alignment 
Range on Protein: 819-1021
Range on HMM: 30-235/235.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA----DTYSYISEFGTTGLKFGAITISVG-RKKEFNAGFLTRDINIRNEEDS
  | |..||.... || . .|.|.  | |||.....|.. |. |   .      .  | .|   . |..| |.. .  ..|| .... .|..........
InAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkee

-MLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVescHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQF
    .|| ..|..   .|. |  .......|. .  .    .. ..|.. |     |  |.|..| ..|.....|. ...||. ..   | ||.. .|. 
sekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq

YAYCYDCLME
|...|....|
Yiflykaile
Y_phosphatase Protein-tyrosine phosphatase 819-1021 1.1e-23 79.3 In-house 30-235 (235) alignment 
Range on Protein: 819-1021
Range on HMM: 30-235/235.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA----DTYSYISEFGTTGLKFGAITISVG-RKKEFNAGFLTRDINIRNEEDS
  | |..||.... || . .|.|.  | |||.....|.. |. |   .      .  | .|   . |..| |.. .  ..|| .... .|..........
InAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkee

-MLLRVKYIQYQDMFlKHCFP-RVDKFMKFIQYCLVQVescHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQF
    .|| ..|..   .|. |  .......|. .  .    .. ..|.. |     |  |.|..| ..|.....|. ...||. ..   | ||.. .|. 
sekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq

YAYCYDCLME
|...|....|
Yiflykaile
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 500-763 4.3e-23 76.5 In-house 19-278 (312) alignment 
Range on Protein: 500-763
Range on HMM: 19-278/312.0
QEMFKEiFESINSTSPDYKCDATLMAQEYdhtkNRFKDIGAFDHTRVVLQETpgvpHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVT
|.. || . ..    .| .| | |  ..     ||. .|  .|  |  |          || ||..|     . ...|| | ..|| .||...    ...
qqltke.ykavgnivsdsectaflkfkdl....nrypniqcwdrgrftlagd....enfyihanfvkictkperfvctqgplentcthfwqlalslgsts

IVMLTNVVDSFKYWP---SDDEVCYG---DIVVRADR--NIELP-----NYVIRGFKVFNKRDrGkKERTILQFHYITWPNKNVPAQASHVLDFMRAINs
|..|. .|.           | | .    |  | ..   .||.      .   | .||  |   | .|  . .. . .||.. .|      | .. |.. 
iillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkat.g.qesklnhyqwaswpdhgmpdscdtalrllsavk.

andsKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIvYG
    |.  ||. |||||||||||.. ..  .  |.   . ..  .  .||..|.. |. . |.|.   .||| . | 
....kdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl.ys
subfamily_CG42327_pd Subfamily CG42327 532-686 1e-22 75.2 In-house 31-192 (319) alignment 
Range on Protein: 532-686
Range on HMM: 31-192/319.0
KNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGYYDD-KLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPS----DDEVCY
|.|. ..  . .||||||. .  ....|..|.|..|| |    |||.| . ...  .|||.||||.. .|| ||.. .       .|.|.    |..  |
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

GDIVVRADRNIELPNYVIRGFKVfnKRDRGKKERTILQFHYiTWPNKNVPAQASHVLDFMRAINS
||| |    .    .|.|  . .  ||  ... | .  . |  |.. .|||. . ..  .  ..|
Gdilvtlkgrevkdryaistlll..krvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 817-1022 1.9e-21 71.5 In-house 75-282 (305) alignment 
Range on Protein: 817-1022
Range on HMM: 75-282/305.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLS----PTDADTYSYISEFGTTGLKFGAITISVGRKKEFNaGFLTRDINIRN-EE
    | |.|||   . .| .  | |.  . |||||.. | |.|. |.      .   . |  |  |   .|| ... .  .|... ....|...| . .|
dyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektas.dyieRklkisiede

DSMLLRVKYIQYQDmFLKHCFPRV-DKFMKFIQycLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQ
|.    |   |  | .  |  |.    ....|.   || .  .  . |.| |   . |  |.| ..   |.|.||| .... .  ..   . .... .|.
dkesrtvlqyqltd.WPdhGvpqfatsllslik..rvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtld

FYAYCYDCLMEY
 | ...| | |.
qYvflhdaldel
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 529-765 2.4e-21 70.7 In-house 47-284 (303) alignment 
Range on Protein: 529-765
Range on HMM: 47-284/303.0
DHTKNRFKDIGAFDHTRVVLQEtpgvphSHYINANYIKgYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTI--VMLTNVVDSFK---YWP-SDDEVCYG
.  |||| |.  .||..| | .      | || |.|..    .|  | || |   |. .||.|. |||   .  ..  .  |..     .|  .| . . 
nmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

DIVVRAD--RNIELPNYviRGFKVFNKrDRGKKERTILQFHYITWPNKNVPAQAS-HVLDFMRAINSA-NDSKECGPVVVHCSAGVGRTGTIIALDIALE
. ..|    ...|| .     .||      |.    .   || .|| ...|...| ...  .  ..|      .. | |    .|.||.||.  .. |  
ersirvgefkrvelgdg..wvlkvlsv.sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

QLKSEN-RVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYGDM
 |.||.  .|.   .. .|. | . ||.|.|| ..|  . | ..   .
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngi
DSPc_SM00195 821-1022 2.6e-21 71.5 In-house 59-261 (263) alignment 
Range on Protein: 821-1022
Range on HMM: 59-261/263.0
AHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA----DTYSYISEFGTTGLKFGAITISVGRKKEFNAGFLTRDINIRNEEDSMLL
| |..|.. .. .|    |...  | |||.....|.. |. |.  .       ..|  |   .  .|| |.. . .... .. . .|......|...   
AnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetr

RVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESChhgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCY
.|. .||..   . .    ..........  . ..    ..||. | .   |  |.|.|. ..|.. ..|  ..| .  ..   | ||.. .|..|...|
kvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiy

DCLMEY
....||
eailey
PTPc_SM00194 821-1022 2.6e-21 71.5 In-house 59-261 (263) alignment 
Range on Protein: 821-1022
Range on HMM: 59-261/263.0
AHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA----DTYSYISEFGTTGLKFGAITISVGRKKEFNAGFLTRDINIRNEEDSMLL
| |..|.. .. .|    |...  | |||.....|.. |. |.  .       ..|  |   .  .|| |.. . .... .. . .|......|...   
AnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetr

RVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESChhgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCY
.|. .||..   . .    ..........  . ..    ..||. | .   |  |.|.|. ..|.. ..|  ..| .  ..   | ||.. .|..|...|
kvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiy

DCLMEY
....||
eailey
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 817-1024 3.9e-21 70.4 In-house 77-284 (319) alignment 
Range on Protein: 817-1024
Range on HMM: 77-284/319.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGTTGL--KFGAITISVGRKKEfNAGFLTRDINIRNEEDSM
.   | ..|||   . ||    | .. .| |||.. ....| .. |.         .... ..    ..| ... .  ..|  ...  |......  . .
dyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeee.ledyiirklklnkkssev

-LLRVKYIQYQDmFLKHCFPRV-DKFMKFIQYclVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFY
   .||  ||.. .  |  |.     .....   ..    .. . || .|     |  | | .|   |.| |.| .... . ...  .| . .. . . |
etRevkhfqyte.WpdhdvPekatslldllkr..irksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqY

AYCYDCLMEYSN
 ..|. |.|. .
kfiyealleave
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 499-757 7.8e-21 68.8 In-house 24-282 (302) alignment 
Range on Protein: 499-757
Range on HMM: 24-282/302.0
NQEMFKEIFESINSTSPDYK-CDatlmAQEYDHTKNRFKDIGAFDHTRVVLQETPgvphSHYINANYIKGYYDDKLYIATQYPSKETC---DNFWRMVWE
..   |. |..|...  |   |     |   .  ||. .|. . |...| |...|     .|.||  ..     .  | .| | ...    ..|||||..
dtaevkkefkkidtmkvdlekCk....afkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfq

QKTVTIVMLTNVVDS----FKYWP--SDDEVCYGDIVVRADRnIELPNYVIRGFKVfNKRDRGKKERTILQFHY-ITWPNKNVPAQASHVLDFMRAInSA
.| |..|.|    .      ...|  |.| . ||.. |   . .|  .     . .      |  .  . .      |..|.|| . ...   .  .  |
ekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrk.Vekaeeektryvi.EvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fa

NDSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVL
...|   ..|.    |.|| |....| .|.|.|.... . |. ||| .|.||...|. |.|.|..| |.|
kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 650-758 2.6e-20 67.3 In-house 181-285 (305) alignment 
Range on Protein: 650-758
Range on HMM: 181-285/305.0
RGKKERTILQFHYITWPNKNVPAQASHVLDFMRainSANDSKecGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVD-IEGIVKVLRQQRTQMVQELCQ
 |.| | . ..|.| ||.. |||    .|...     |  ||  ||.|||||||.||||... |.  |.|| . . ..  . |.. .|.|| . .|   |
pgekarkvthyhwidwpdrgvpaadlailelle...karpsk..gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaq

FVFIYNAVLE
..|... .|.
ylfvhqviln
subfamily_CG42327_pd Subfamily CG42327 689-756 5.5e-20 66.3 In-house 243-311 (319) alignment 
Range on Protein: 689-756
Range on HMM: 243-311/319.0
DSKECGPVVVHCSAGVGRTGTIIALDIALEQLKSE-NRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAV
  .. ||.||||| ||||||..|| |||...|.   . |||  .|  .|..|.. |..  |. |||. .
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 529-683 1.7e-19 64.8 In-house 32-192 (297) alignment 
Range on Protein: 529-683
Range on HMM: 32-192/297.0
DH-TKNRFKDIGAFDHTRVVLQEtpGVPHSHYINANYIKGY--YDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS-----FKYWPSDDE--
    |||..|| |.| ||| |.   ... . ||||.|.       |  || .| | ..| |.||..|.||   .|||.... .      . |||| ..  
sslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

VCYGDIVVRA--DRNIELPNYVIRGFKVFNKrdrgKKERTILQFHYITWPNKNVPAQASHVLDFMRA
   ||.||    .   |  . ..  .... .    ...| .    ...||.. ||..   .  |   
lkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 820-1023 5.3e-19 63.4 In-house 78-280 (318) alignment 
Range on Protein: 820-1023
Range on HMM: 78-280/318.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEF--GTTGLKFGAITISVGRKKEFNAgFLTRDINIRNEEDSMLLR
 | |.|||   . .| .  |  .  | |||..  .... |. |. .   .   .  .  .    ..|.... .  ..|..  .. | ......| .    
nanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsd.yvlrefkvtrteeeesrq

VKYIQYQDMFLKHCFPRVDKFMKFIQYclVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYD
|.  .| .   .     . .......   |.    ..|..||..|  .  |  |.| ..   |.|.|.| .....|  ..   | . ..   . | ..||
vrqyhytsWpdegvpesgaslldlvrq..vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiyd

CLMEYS
 |.|. 
vlleal
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 819-1022 1.1e-18 62.5 In-house 87-289 (298) alignment 
Range on Protein: 819-1022
Range on HMM: 87-289/298.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA-DTYSYISEFGT-TGLKFGAITISVGRKKEFnAGFLTRDINIRNEEDSMLL
  | .|..|   | || .  | .  .| |||...... . |. | ..   |.  |   . .    ..| ||.|. .|.|| | . .| ... ... .   
iNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeef.adlivrklkvskkkeeker

RVKYIQYQDmFLKHCFPRVD-KFMKFIQYclVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYC
.|. ...   .  .. |..    .....   |.    . ||.|....     |  | |  .   |.|.|||. . ..|. .    . ||..   . |...
evrqlhfts.Wpdkgvpenatsvldllrk..vrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfi

YDCLMEY
|.  .|.
yeavlea
0045098 (Phosphotyrosine protein) phosphatases II 821-1024 1.9e-18 62.3 In-house 56-273 (278) alignment 
Range on Protein: 821-1024
Range on HMM: 56-273/278.0
AHYLDGYwtPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADT----YSYISEfgTTGLKFGAITISVGRKKEFnAGFLTRDINIRNE----ED
| |.|||  |. ||    |...... |||.. . ....|..| .   ..    . |  |     | .| .|. .   ...   . .|.....|     ||
Asyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltygdftvtllseevl.ddytlrtllvtnltvered

SMLLRVKYIQYQDMFLKHCFPRV--DKFMKFIQYCLVQVE----------SCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAkkERIINILQAANHHYL
 . . |....|  .   .. .    . | .......  ..          ... ...|.| |     |  | .. . ..|..   |. ...|.| ..   
lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrs

QSPG-LIVNLQFYAYCYDCLMEYSN
| ||  . ||..| ..|..|.|. .
qRpglavqnleqyrflyefllelll
0037934 (Phosphotyrosine protein) phosphatases II 816-1022 2e-18 62.3 In-house 32-241 (243) alignment 
Range on Protein: 816-1022
Range on HMM: 32-241/243.0
ETMFTAHYLDGYwtPNlFIKSPCPTKDNTEC----FWRLIIHKKCSHIINLSPTD----ADTYSYISefGTTglKFGAITISVGRKKEFNAgFLTRDINI
. .. | . ...  |. .| . .|.....|     |||.. . ....|..| ...     . . | .  |..   .| .|. .   ....  .  | . .
sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev..tygdftvtllseehldd.ytvrtlll

RNEE-DSMLLRVKYIQYQDMFlKHCFPR-VDKFMKFIQYCLVQVES-----CHHGNHPILMHDDGSNGPIGIFATLTYCLQRAkkeRiINILQAANHHYL
.| . |   . |  ..|  .   |. |  .. ...|....   .|.     . ....|.| |  .  |  | .... ..|..    . .....| ..   
enldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllre

QSPG-LIVNLQFYAYCYDCLMEY
| ||  . ....| ..|..|.|.
qRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 508-608 2.6e-18 60.8 In-house 29-124 (305) alignment 
Range on Protein: 508-608
Range on HMM: 29-124/305.0
ESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLqeTPGVPHsHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVV
 ...      |  |   ||  .. |||.||.| .|. || |   .  || .|| |||.    . | .| || | ..|| .|| | ...|  .| || |..
vamkrfndfekmkafkeaq..eagknrykdvgcldnnrvkl..egpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnll

D
.
e
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 530-784 3.3e-18 60.8 In-house 19-274 (290) alignment 
Range on Protein: 530-784
Range on HMM: 19-274/290.0
HTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKgYYDDKLYIATQYPSKET-------CDNFWRMVWEQKTVTIVMLTNVVDS------F---KYW
| ...  ..  . .|||||..      . || ||... . ..   |.|| | ...         .|| |. . |   .||| .. .       |   || 
hemdqRlevpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PS--DDEVCYGDIVVRADRNIELPNYVIRGFKVfnKRDrGKKERTILQFHYITWPNKNVPAQASHVLDFMRAINsandsKECGPVVVHCSAGVGRTGTII
|   ..|. .... |.    ..  .  .|   |  | | ...| |.    .  | . ||. .   .|. .. ..     ..  ||.|||  |. |  .. 
pesvgeelkfkgltvkCkskekeddvetRelvv..kfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAala

ALDIALEQLK-SENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLedivygdmsTLIDEFSNHYIKSQEEAT
|....   .  ... | .| ..|.||.|| .....  .. |.  ...          |. |. ........|  
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.........llaievldqfaeeetekk
subfamily_PTPRD_pd Subfamily PTPRD 821-1025 5.5e-18 59.9 In-house 81-283 (564) alignment 
Range on Protein: 821-1025
Range on HMM: 81-283/564.0
AHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEF-GTT-GLKFGAITISVGRKKEFnAGFLTRDINIRNEEDSMLLRV
| ..||| ... .| .  |... .| |||..  ...| |. |. .   .   ....  ..   ..| .|...  ..|. | .  |.........|    |
AsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeel.adyeirtfklkkkkssesreV

KYIQYQDmFLKHCFP-RVDKFMKFIQYCLVQVEschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYD
.  .. .    |. |    .....|. .    |   ....||. |     |  |.| .. ..|.|.|.|. ..| |  ..   | . .. . . |.....
rqFhFts.WPdhgvpesatslLdlirkvralne...pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFihe

CLMEYSNK
 ..|. ..
ailealac
subfamily_CG7180_pd Subfamily CG7180 820-1022 7.5e-18 59.2 In-house 74-289 (296) alignment 
Range on Protein: 820-1022
Range on HMM: 74-289/296.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGTT-GLKFGAITISVGRKKEFNAgFLTRDINIRNE--------
 | | |..  .. .|    |.|.  . ||||.  ...| ...|. |   .  | | .  .   ..| | . . ..|.. . . .| . .  .        
navyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyan.lkirtfkltkkivalteqe

--EDSMLLRVKYIQYQDMFLKHCFPRV-DKFMKFIQYCLVQVESC--HHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGL
  ..     || .|..   |.. .| .   ......   . .|    .  . |....     .  |.. ..  .|. ..||  ... .|.     . |.|
kqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqL

IVNLQFYAYCYDCLMEY
. | . | |.|| | |.
venveeYkyiYdvllea
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 577-756 1.2e-17 58.3 In-house 96-284 (302) alignment 
Range on Protein: 577-756
Range on HMM: 96-284/302.0
TQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSF-----KYWPS--DDEVCYGDIVVRA-DRNIELPNYVI-RGFKVF-----NKRDRGKKERTILQFHY
   | |.|.. .| .. . ..  .| |...|..      .|.    ..|. .|   |.. . . .| ..   ..||..     |.. . |...|.  ...
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

ITWPNKNVPAQASHVLDFMRAINSANDSkecgpVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAV
 .||..  |..| . || ..  .|   .     |.||||||||||||..|.   ..  . ..  |.  ||. .|| |   ||.  | ...   |
sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 808-1030 6.5e-17 56.4 In-house 49-266 (267) alignment 
Range on Protein: 808-1030
Range on HMM: 49-266/267.0
VVPFDYGEETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYI--SEFGTtGLKFGAITISVGRKKEFN-AGFLTRD
.|..   ||    | |..|| | | ||    | |     |. .|...|.. |. | ..  |    .   ..|    |.  .|.    .|| |    .| .
rvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgq.akkyqdltvehslekeendyqiitle

INIRNEEDSMllrVKYIQYQDMFLKHcfpRVDKFMKFIqYCLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPG
....||       |    |.   ..        ..| . . ..  .    ||.|.... .   |  | | ..   |.|||.| . .| .   .   | .|
lkfknesahn...vtlyyykkwnint...nnkpylkpl.fgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqrig

LIVNLQFYAYCYDCLMEYSNKLLKEE
|.  .. | |... | ||..  ||||
lvdtkeryiyihellaeyaegrlkee
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 675-757 7.1e-17 56.1 In-house 245-341 (350) alignment 
Range on Protein: 675-757
Range on HMM: 245-341/350.0
SHVLDFMRAINSaNDSKECGPVVVHCSAGVGRTGTIIALDIALE------QL-------KS--ENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVL
....| . | .   |...  |..||||||||||||...||  |.      .|       .   . |  |. ||. ||.|| .|||.| ||.|||.|.|
ndliddlfaesh.ldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 584-776 8.9e-17 56.0 In-house 40-238 (255) alignment 
Range on Protein: 584-776
Range on HMM: 40-238/255.0
TCDNFWRMVWEQKTVTIVMLTNV-----VDSFKYWPS--DDEVCYGDIVVRADRniELPNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQASH
| |.|....  .|| ..|||..      ..  .|.|   |.   . |. | . .     . |.|  ..  .  . || .|.  ..|  |..|| | .|  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VLDFMRAInsaNDSKecgPVVVHCSAGVGRTGTIIALDIALE----QLKSENRVD--IEGIVKVLRQQRTQMVQELCQFVFIYNAVLeDIVY--GDMSTL
.|  ....    |||   .||||||.|.||. . .  ...      .|.  . |.     ... ||..|.. ...  |. |    || |.|.  |..   
ilnilkvv...rdsk...svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl.dlvfpkgeleak

IDEFSNHY
  |  . |
yqeirksy
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 820-1024 2.2e-16 54.8 In-house 41-243 (250) alignment 
Range on Protein: 820-1024
Range on HMM: 41-243/250.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFG-TTGLKFGAITISVGRKKEFnAGFLTRDINIRNEEDSMLLRV
 | .|.||   ..|| .  | .. .| |||.....| . |. |.        |   .   .  |.| .|.|.  |.|| | . .| . . ... .    |
nasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdvtvsllskeef.adytkrklklskakkaderiv

KYIQYQDmFLKHCFPRVDK-FMKFIQYclVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYD
. ...   .   . |.| .  .....   || .  . || |....     |  | | ..   |.|.|||..... .  .    . |. .  |. | ..| 
rqlhfvv.WPdkgvPevatavLellkk..vqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvye

CLMEYSN
 .... .
iilkald
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 819-1021 2.6e-16 54.4 In-house 80-277 (315) alignment 
Range on Protein: 819-1021
Range on HMM: 80-277/315.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYIS-EFGTTGLKFGAITISVgRKKEFNAGFLTRDINIRNEED-SMLL
  | ..|||  .. .| .  |     . ||||. ......|. |. .  .  .     .    . .| ||..  ...| |  .  | . .  ...   ..
vnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtr.kseevnteytvrtlsvvfgdnirevv

RVKYIQYQDMFLKHcfpRVDKFMKFIQYCLVQVESCHhgnHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCY
...|  . || . .       .|..|.   .  ..      .|..| .   |  | | ||   |..|. |..|.. .. .    .  ...  .. | . |
qlhytswpdmgvpk...ytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiy

DCLME
| |.|
dalle
subfamily_PTPRG_pd Subfamily PTPRG 820-1022 3e-16 53.8 In-house 80-286 (563) alignment 
Range on Protein: 820-1022
Range on HMM: 80-286/563.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP----TDADTYSYISEfgTTGLKFGAITISVGRKKEfNAGFLTRDINIRN-----E
 | |.|||   . || .  | || ...|||.|  .. . |. ..     .  .   |  .   . ...||...   ...   |   .| . |.|     .
nAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeev.lalytvrtlviknlklkkk

ED-SMLLRVKYIQYQDmFLKHCFPRVDKFMkfIQYCLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNL
..    ..|.  .| . .  |. |    .   ...   .  . ..   ||..|..   |  |..  |.  |.. ..| ..|... . |  .| . |. . 
kqcdteklvrqyhytk.WPdhgvPehslpv..LifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqte

QFYAYCYDCLMEY
  | . .| |.| 
EqYiflhdallea
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 820-1021 5.6e-16 53.9 In-house 57-253 (284) alignment 
Range on Protein: 820-1021
Range on HMM: 57-253/284.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSptDADTYSYISEFGttGLKFGAITISVGRKKEFNAgFLTRDINIRNEEDSMLLRvK
 | .. ||  .. .| .  | ..  . |||.|   .|| |. |.  .     |    .    | .   ..|   .| .  .  |||.. ..      | |
nasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplki..vikeerfkvkvdsveesee.yvvrdielsedgkekdir.k

YIQYQD-MFLKHCFPRVDK-FMKFIQYcLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYD
  |.    . ..  |     .|....  .  ..| ......|..|     |  |.. .|   |.| |.|. ... .  .    | . |. .|  | ..| 
irqfhflgwpdvgvpdypsdlmrlvkk.vrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

CLME
 |.|
alle
subfamily_PTPRA_pd Subfamily PTPRA 820-1023 5.9e-16 53.3 In-house 90-295 (330) alignment 
Range on Protein: 820-1023
Range on HMM: 90-295/330.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD----ADTYSYISEFGTtgLKFGAITISVGRKKEfNAGFLTRDINIRNEEDSML
 | ..|||   . || .  | ..  | |||.|  .| . |. |.  .       . |  . |.  . .| |...|  ...    .  |.. ...  |.. 
nasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl..vtyGnirvevedetv.lvdytvrkflvqqlpdatr

LRVKYIQYQdmFLKHCFPRV-----DK-FMKFIQycLVQVESCHHGNhPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNL
 . . .  |  |  . .| |      .  .|...   |.     ... || .|     |  | | .|   |.| | ||.... .. ..  || | ..  .
ekksrlvrq..fhftswPdvGvPfepiGmlkllk..kvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtd

QFYAYCYDCLMEYS
. | ..|  |.|| 
eqyefiykvlleyy
subfamily_PTPRK_pd Subfamily PTPRK 818-1021 6.2e-16 53.1 In-house 73-275 (314) alignment 
Range on Protein: 818-1021
Range on HMM: 73-275/314.0
MFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADT-YSYISEFGTTGLKFGAITISVGrKKEFNAGFLTRDINIRN--EEDSM
   | ..|.|  |. ||    | .. .. ||||. ...|. |. |.   . . .  .  .   . ..| | . .  . | .| ...|  ....     . 
yinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelv.etellaelvvrifrveklargqee

LLRVKYIQYQDmFLKHCFPRV-DKFMKFIQYCLVQVESchhGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYA
   |. .|.   . .|  |     ..|...    . |    .. .|..|     |  |.| ...  |. ...|..... .|.     . . ..   . | 
irevrqfqflg.WpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqyk

YCYDCLME
..|| ..|
fiydvile
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 820-1021 9.1e-16 53.0 In-house 93-289 (319) alignment 
Range on Protein: 820-1021
Range on HMM: 93-289/319.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSptDADTYSYISEFGttGLKFGAITISVGRKKEFNAgFLTRDINIRNEEDSMLLRvK
 | ...||  .. .| .  | ..  . |||.|   .|| |. |.        |    .    | .   ..|   .| .  .  |||.. ..      | |
nasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplki..vikeerfkvkvdsveetae.yvvrdielsedgkekdir.k

YIQYQD-MFLKHCFPRVDK-FMKFIQYcLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYD
  |.    . ..  |     .|....  .  ..|  .....|..|     |  |.. .|   |.| |.|. ... .  .    | . |. .|  | ..| 
itqfhflGwpdvGvpdypsdlmrlvkk.vrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

CLME
 |.|
alle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 820-1025 1.3e-15 52.1 In-house 80-285 (290) alignment 
Range on Protein: 820-1025
Range on HMM: 80-285/290.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPT----DADTYSYISEFGTTGlkFGAITISVGRKKEFNaGFLTRDINIRNEEDSmL
 | |..||   . .|    |...    ||.|| ..|.. |. |           . | .. .|.   .| ..| .   ...| .. .| ....|.. .  
nAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetln.eyierklevknknsa.g

LRVKYIQYQ--DMFLKHCFPRVDKFMKFIQycLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYA
 . . .|||   .  .   .     .  |.   ..    ..||..|..|  .. |  ..| ...  ....|.|  |...|  ..   | ||..   | | 
akqsvtqyqitnwdstgkvtnpqtillvie..emyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyq

YCYDCLMEYSNK
. .. ...| ..
gifqivltylds
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 519-614 2.6e-15 51.0 In-house 37-151 (350) alignment 
Range on Protein: 519-614
Range on HMM: 37-151/350.0
CDATLMAQEYDHTKNRFKDIGAFDHTRVVLQET----PGVPHSH----YINANYIKGY-----YDDKL-YIATQYPSKETCDNFWRMVWEQKTVTIVMLT
 |  |       .|||.|.|  ..|.|| |...     .. ||.    ||||||.|        . .  ||||| | ..| |.|.... . |   |..||
nDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslt

NVVDS-----FKYWP
. |.       .||.
sdvelnlekcyrYWq
subfamily_Ptp69D_pd Subfamily Ptp69D 819-1025 3.4e-15 51.0 In-house 79-288 (307) alignment 
Range on Protein: 819-1025
Range on HMM: 79-288/307.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGT--TGLKFGAITISVGRkKEFNAGFLTRDINIRNEEDS---
  | .. ||   . || .  |     . |||.|  ..   |. ||  .  .   .. . .  .  ..| | . . . .|.   .  |.... . ...   
inasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvs.eekhsdyiiReldvskkkeesge

MLLRVKYIQYQDMFL-KHCFPRV-DKFMKFIQYC--LVQVEschhgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNL
.  . | .||. .       |.|    .|.|.    | . .     . ||..|     |  ||| .|.  ||. |.|  ..| .   .   | . |. .|
vedsrkvvqyhytgWkDskvPevargllklieqvrelykln.....rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsl

QFYAYCYDCLMEYSNK
. | ..|  |..||..
eqYvflyralldyssy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 695-760 3.6e-15 50.6 In-house 230-295 (297) alignment 
Range on Protein: 695-760
Range on HMM: 230-295/297.0
PVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDI
...|||||||||.| ..  |. |..|. .   |.  |...||.||...|| | || ..|.|||. .
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 819-1023 6e-15 50.0 In-house 74-278 (287) alignment 
Range on Protein: 819-1023
Range on HMM: 74-278/287.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP----TDADTYSYISEFGTtgLKFGAITISVGRKKeFNAGFLTRDINIRNEE-DS
  | ..|||   . || .  |  .    ||.|| ... . |. |.     ..   | | .|  .  . .|  .|..  ..  |||.. |.....|.. ..
inavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.vnagyierklevknknkag

MLLRVKyiQYQDMFL--KHCFPRVDKFMKFIQYclVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQF
  ..||  |||      .   ..    .  |.      .  ..|| .|..|   . |  ..|      ....|.| .|...|  ..   | || .   . 
dkqqvk..qyqitnWdstgkvtepqtillviee..myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveq

YAYCYDCLMEYS
| . .| ..|| 
ykfindivleyl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 697-761 7.5e-15 49.1 In-house 2-66 (69) alignment 
Range on Protein: 697-761
Range on HMM: 2-66/69.0
VVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIV
|||||.| |||||.||. . . ..|||  |||   |. .|. |  || .  ...||..|. | . 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 820-1023 1e-14 49.3 In-house 79-279 (288) alignment 
Range on Protein: 820-1023
Range on HMM: 79-279/288.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPT----DADTYSYISEfGTTGLKFGAITISVGRKKEFNAgFLTRDINIRneEDSML
 | |.||.   . .| . .|  |  . ||.|.  .| | |. |.      .     |  . . .  ..| .|. .  .|| .  |..| . .    .   
nasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd.adkpknyGsvtvtlveskeled.fvlrkllle..kkkte

LRVKYIQYQdMFLKHCFPRVDkfMKFIQYcLVQVESCHHGN-HPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAY
|...  ||. ..  |  |.    . .... | ||.  .. .  ||..|     |  |.| .|   ... ..|  |... . ..   | . |. .|. | .
leitqyqyl.aWpdhgvPesk..apllel.lrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYef

CYDCLMEYS
.|..|..  
iyevllsli
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 831-1021 2.1e-14 48.1 In-house 75-264 (283) alignment 
Range on Protein: 831-1021
Range on HMM: 75-264/283.0
NLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGT--TGLKFGAITISVgRKKEFNAGFLTRDINIRNE--EDSMLLrVKYIQYQDM
. .| .  | ..    ||... ..| . |. |..   |     | .       ..|  |... ||   .  |  . . .|..    | || . . |..| 
kkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtl.rkettsnsfiikelllrvnssakstll.lahyqvidW

FLKHCFPRVDKFMKFiqyCLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLME
      . .. ..||    .|.    .. . ||..|     |  ..| ...  .. |. | .... .  .    | .... .|. |   ..  .|
leygeqaiinslvkf...nkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
0051429 (Phosphotyrosine protein) phosphatases II 821-1027 4e-14 48.4 In-house 9-229 (272) alignment 
Range on Protein: 821-1027
Range on HMM: 9-229/272.0
AHYLDGYWT---PNLFIKSPCPTKDNTECFWRLiIHKKCSHIINLSPTD----ADTYSYIS----------EFGTTGLKFGAITISVGRKKEFNAGFLTR
| ...||.    |.... |..|.. . . ||||  . ....|..| ...     ... |.           .....   .||... .  .. ..   |..
ardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilre

DINIRNEEDSMLLRVKYIQYQDMFLKHCFPRVdkFMKFIQYCLVqveschhgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIIN--------ILQAA
 . ..    .. ..|  ..|.|.   .  .    . ......|         ..|.|.|  .  .  |... | ..|..  .| |..        ...| 
llltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeav

NHHYLQSPGLIVNLQFYAYCYDCLMEYSNKLL
..   | || . . ..|...|..|.|. ..||
eelraqrpgavqteeqylflyeallellrsll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 816-1023 4.3e-14 47.4 In-house 76-288 (325) alignment 
Range on Protein: 816-1023
Range on HMM: 76-288/325.0
ETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTY---SYISEFGTTGLKFGAITISVGRKKEFnAGFLTRDINIRNEED
   . | ||  .   . |. .  |  . .. .|||..  .|| .. |   | .      |  .      .||.. ...   .|. . .. | ..... ..
sdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkk

SMLLRVKYIQYQ---DMFLKHCFPRVDKFMKFIQYCLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNL
   . ||  |.|   ||  ..    .  ... ..    .| .  ..  |||.|     |  |.|..|   |..  .|  ..|..  ..   . | ..   
GetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetv

QFYAYCYDCLMEYS
  |  .|..|.|. 
dqyiliyealveay
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 697-763 4.4e-14 46.6 In-house 1-67 (69) alignment 
Range on Protein: 697-763
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVFIYNAVLEDIVYG
|||||.| ||||| ||. . . ..|||  |||   |. .|. |  || .  ...||..|. | .  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 815-1023 7.7e-14 46.2 In-house 71-277 (315) alignment 
Range on Protein: 815-1023
Range on HMM: 71-277/315.0
EETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPT---DA-DTYSYISEFGTTGLKFGAITISVGrKKEFNAGFLTRDINIRNE
..  . | |. .. . . .| |  | |   . |||.....| . |. ..     |      |  .  .   .||.| ...  . | ...  .| . .|. 
dsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvell.sleadtdgvarklvtrks

EDSMllRVKYIQYQDMFLKHCFPRVDKFMKFIQYclVQVEsCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQ
|.|   .|   |...   |    ..  ..|.|.   |. .  .. ....|.|     |  |.. ..  .....|..| .....  .    . | |.   .
eesr..tvtqfqftewPdkGvdkqtssllklike..vkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqtee

FYAYCYDCLMEYS
 ||. || ..|. 
eyafiydavledl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 816-1037 9.2e-14 45.4 In-house 71-288 (515) alignment 
Range on Protein: 816-1037
Range on HMM: 71-288/515.0
ETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA-DTY---SYISEFGTTGLKFGAITISVGRkKEFNAGFLTRDINIRNEE
.  | | |. .. . . .| |  | |  .. ||||..... . |. ..     |      |  .  .  .||| | ...    |  .| . | ...  ..
sdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvs.leactggikrkltvlkgd

DsmLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYclVQVESCHHgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQF
|     |   ....   |   ..   ..|.|.   |. .  .  .||...|     |  |.. ..  .. .||. |......  .    . | |.   . 
d..srtvtqfhfteWPdkGvpkhtssllklike..vkadhgqy.thpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeq

YAYCYDCLMEYsnKLLKEEYFPSIHE
||. |. ..|.   | ..   | || 
yafiygavled..llwrntlipvihf
0036282 (Phosphotyrosine protein) phosphatases II 819-1017 9.9e-14 46.9 In-house 5-164 (174) alignment 
Range on Protein: 819-1017
Range on HMM: 5-164/174.0
FTAHYLDGYWTPNLFIKSPCPTKdntecFWRLIIHKKCSHIINLSPTDADTYSYISEFGTTglkfgaitisvgrkkefnagfltrdinIRNEEDSMLLRV
. | .||... .. .| . .|..     ||... . .......| .   . .  .  .  .                            |. .  . ...
inaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...........................lredlerlgiqy

KYIQYQDMFLKHCFPrVDKFMKFIQYCLVQveschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKkERIINILQAANHHYLQSPGLIVNLQFYAYCYD
.|.   |.        ...|.||.. .| .     ....|.| |  .  |  |... . ..|.. . |. ...|.      || || . . ..| ..|.
lylpwpDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_hpo-7_pd Subfamily hpo-7 583-777 1.1e-13 45.7 In-house 45-248 (263) alignment 
Range on Protein: 583-777
Range on HMM: 45-248/263.0
ETCDNFWRMVWEQKTVTIVMLTN-----VVDSFKYWPS--DDEVCYGDIVVRADRNIElpNYVIRGFKVFNKRDRGKKERTILQFHYITWPNKNVPAQAS
.| |.|....  .|| ..|||..     |..  .|.|   |.   . .. | . . ..  . ...  .. .  .. || .|. .. |  |..|| | .| 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

HVLDFMRAinsANDSKEcgpVVVHCSAGVGRTGTIIALDIALE----QLKSENRVDI--EGIVKVLRQQRTQMVQELCQFVFIYNAVLE----DIVYGDM
 .|  ...   | .||.   .|||||.|.||.      ...      .|.  . |..    ... ||..|.. ...  |. |    ||.    .   |..
eilnilkv...arnsks...lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgel

STLIDEFSNHYI
..  .|  . |.
eakyqeirksyl
subfamily_PTPRB_pd Subfamily PTPRB 820-1024 1.5e-13 45.4 In-house 83-286 (293) alignment 
Range on Protein: 820-1024
Range on HMM: 83-286/293.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFG---TTGLKFGAITISVGRKKEFNaGFLTRDINIRNEEDSMll
 | |..||..|. || .  |  . .. |||..  ||.| |. |  .         |.    ..   .| |....  ..| .  . .|...|..|....  
nanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeele.dwvirelkiekekeer..

RVKYIQYQdMFLKHCFPRV-DKFMKFIQYCLvQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYC
.|.  ...  .  |  |   .....|..    .. . .. ..||..|     |  |.| .|   ||. ..| ...|.    .   .   |. . . | . 
kvrqyhft.sWpdhgvPektktlldfvrtvr.eaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifi

YDCLMEYSN
..|.... .
hqcvldllr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 676-758 3.4e-13 43.6 In-house 249-342 (349) alignment 
Range on Protein: 676-758
Range on HMM: 249-342/349.0
HVLDFMRAINSaNDSKECGPVVVHCSAGVGRTGTIIALDIALE----QLKSENRVD--------IEGIVKVLRQQRTQMVQELCQFVFIYNAVLE
...| . | .   |...  ...|||||| ||||... ||. |.      .  |...        |  ||  ||.|| .|||.| ||..||.|.|.
dliddlfarly.ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
0041856 (Phosphotyrosine protein) phosphatases II 817-1023 1e-12 43.5 In-house 20-171 (182) alignment 
Range on Protein: 817-1023
Range on HMM: 20-171/182.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSptdadTYSYISefgttglkfgaitisvgrkkefnagfltrdinirNEEDSMLL
.. .|....|.. .. ||    |.......|.|.. . ....|.||.      . |                                    ...  . .
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp..................................ellerlgi

RVKYIQYQDmflkHCFPRVDKFMKFIQYCLVqveschhGNHPILMHDDGSNGPIGIFATLTYCLQRakkeRiINILQAANHHYLQSPGLIVNLQFYAYCY
...|..  |    |. | .|.. .||. .|         ..|.| |  .  |  | .. . .....    . ... .| ..   . || ......| ...
qylylpwpD....hgvpdldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflq

DCLMEYS
..|.|. 
lallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 821-1022 1.1e-12 42.7 In-house 84-283 (297) alignment 
Range on Protein: 821-1022
Range on HMM: 84-283/297.0
AHYLDGYWTpnLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA---DTYSYISEFGTTGlkFGAITISVGRKKEfNAGFLTRDINIRNEEDSMLLR
| .. |.     .| .  | |.  . ||....... | |. |.  .        | |. |.|   || ... .   .|   ||. |........  .   
asfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt..fGdvsvvllsvse.reGfikrelevtkgkakarrv

VKYIQYQDMFLKhCFPRVDKFMKFIQYcLVQVESCHHGN-H-PILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYC
||  |. .   |   .| |.  ..... . .|.  . .| . |.|.|     |  |.. |.  .. .||.|  ..|..  ..   . | |.   . |.. 
vkqyqfveWPdk.averkdsassllkl.isevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfv

YDCLMEY
|  ..|.
yvavlea
subfamily_PTPN3_pd Subfamily PTPN3 831-1024 5.8e-12 40.1 In-house 84-276 (280) alignment 
Range on Protein: 831-1024
Range on HMM: 84-276/280.0
NLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD----ADTYSYISEfGTTGLKFGAITISVGRKkEFNAGFLTRDINIRNEEDSMLLRVKYIQYQDm
| .| .  | .. .. ||... ..|.| |. |  .        . |  |  .  |..| ... . .. . .  ...|.. ....| .   ..  .|| . 
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqyla.

FLKHCFPRVD-KFMKFIQyclvQVESCHH-GNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEYSN
.  |. |    .|..|..    .|.....  ..|...|  .  |  |.. .|  .|.   ... ...|.   .   |   |. . . | .  ..... ..
WpdhgvPddsadflefve....rvrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_PTPN9_pd Subfamily PTPN9 819-1025 1.3e-11 39.0 In-house 73-292 (297) alignment 
Range on Protein: 819-1025
Range on HMM: 73-292/297.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDA----DTYSYISEFGTTGLKFGAITISVGRKkEFNAGFLTRDINIRN---EE
  | ..|||  .. ||    | |  .. |||..  ...  |.    .          |  .   .  .|| ...|.    | .  . .| ..|.|   ||
inanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvev.eeeedykvrvleiknvktee

DSMLLRVKYIQYQDMFLKHCFPRVDKFMK---FIQYCLVQ----VESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPG
   .   ... . |    .    . ....     | ..|.     .  |  . ||..|     |  | |.|| .||.| ...  ... .. ..   |   
srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqraf

LIVNLQFYAYCYDCLMEYSNK
 |   . |..|| ...||. .
siqtpeqyefcylavleyale
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 521-603 1.6e-11 38.3 In-house 29-116 (347) alignment 
Range on Protein: 521-603
Range on HMM: 29-116/347.0
ATLMAQEYDHTKNRFKDIGAFDHTRVVLQ-----ETPGVPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVML
 |    | . .||| ||    | |||||       ..  .   |||| .||    .| || ||||  .|  .||.||   |   .| .
ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 486-578 2.8e-11 37.4 In-house 8-94 (95) alignment 
Range on Protein: 486-578
Range on HMM: 8-94/95.0
TEFQEHVEQLNKNNQEMFKEIFESINSTSPdykCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETpgvPHSHYINANYIKGYYDDKLYIATQ
. |. || ..  | .. | . | ||. ||    .  |  . | .  |||| .|  .| |||||        | |||| .. ||   . |||.|
svfhshvlemhsnsdqefdnefksismtsg...apytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 819-1022 8.8e-11 36.1 In-house 68-276 (287) alignment 
Range on Protein: 819-1022
Range on HMM: 68-276/287.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINL----SPTDADTYSYISEFgTTGLKFGAITISVGRKKEFNAGFLTRDINIRNEEDSM
  | |. .|   . || .  |       |||...... . .| .      .   .| |  |     .. |  .. .  ..  .  . .| . . . |   
inanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletre

LLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESCHHGN--HPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFY
   || ... ..  |   |    ...|.  .  ..|    ..   |...|||   |  ||. ..  ...| ..   ... ..  .   .  .|.     .
arvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvql

AYCYDCLMEY
 . |. |. |
rllyealvty
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 823-1020 2.5e-10 34.3 In-house 228-435 (440) alignment 
Range on Protein: 823-1020
Range on HMM: 228-435/440.0
YLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGTTGLKFGAITISVGRKKEFNAgFLTRDINIRNEEDSMLLRVKYIQ
 ..||   | || .  |       ||||.   . | || |   .  | |      |  . || .|.     ...|     | ....  |.   .|   .|
efegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnr.vkvrtlelkykeevheirqfevq

-------YQDMF-LKHCFPRVDKFMKFIQYCLVQV--ESCHHGN-HPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQF
        . .   . |.  | ..| ... | .|   |    |.  |||.|        |.| |.  ||.. ...  |...|      |  | ..  |  
twptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltd

YAYCYDCLM
|  ||  | 
yllcykllt
subfamily_eak_pd Subfamily eak 540-674 2.7e-10 34.1 In-house 62-198 (332) alignment 
Range on Protein: 540-674
Range on HMM: 62-198/332.0
AFDHTRVVLQETPGVpHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVD-----SFKYWPSDD--EVCYGDIVVRADRNI
 .|.  | |  .    .  ||||  ..     . || |  .|..    ||.|| |||. .||.| . |.     | ||.| .   |. .| . |     .
pydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefv

ELPNYVIRGFKVfnkrDRGKKERTILQFHYITWPNKNVPAQA
.  ..  | ...     .| .   .| ...  | . ..|   
krniletrllel....skGnethrvlhykvfGwtettlpkye
0043147 (Phosphotyrosine protein) phosphatases II 817-1016 4e-10 35.2 In-house 6-154 (172) alignment 
Range on Protein: 817-1016
Range on HMM: 6-154/172.0
TMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTdadtysyisefgttglkfgaitisvgrkkefnagfltrdINIRNEEDSMLL
..  | |||.|. |. ||    |.  ... |||.. .....||.|| .                                         ...  .  . .
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.......................................lydpellerlgi

RVKYIQYQDMFLKhCFPRVDKFMKFIQYCLvqvesCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANhhylqsPGLIVNLQFYAYCY
.. |. . |.     .  ...|..||.  |     .   ..|.| |  .  |  | .. . ..|.. . | ... ....       || . | ..| ..|
qylylpwpDhgvp.llellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylmllglsleeavalvrekR......pgavqnpsqyrfly
0038934 (Phosphotyrosine protein) phosphatases II 658-713 4.2e-10 35.1 In-house 80-135 (194) alignment 
Range on Protein: 658-713
Range on HMM: 80-135/194.0
LQFHYITWPNKNVPAQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIAL
.... . .|..... . . .|.|.....  .. .. | |.||| ||.|||||..| 
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 518-606 6.9e-10 32.8 In-house 37-141 (349) alignment 
Range on Protein: 518-606
Range on HMM: 37-141/349.0
KCDATLMAQEYDHTKNRFKDIGAFDHTRVVLQETPG----VPHSH----------YINANYIK--GYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIV
  |  |       .|||.|||  ..|.||.|....     . .|.          ||||||.|   .  .| ||||| |.  | |.|....  ..   ..
iddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvl

MLTNV
 |.. 
sLndd
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 528-679 7.2e-10 32.0 In-house 26-163 (169) alignment 
Range on Protein: 528-679
Range on HMM: 26-163/169.0
YDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINAnyikgyyddklyiatqypsketcdnfwRMVWEQKTVTIVMLTNVVDSFKYWPSDDE------VC-
 ..||||     |  |||| ||       | ||||                           ||.||  .  ||.| .  |   .||  ..      |  
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil

---YGD-IVVRADRNIELPNYVIRGFK---VFNKRDRGKKERtILQFHYITWPNKNVPAQASHVLD
   | | . ||.|.   . . |   |.   |. . |.   |. .  .|| |||.. ||    ||  
gewytdslyvrtdkvhantsgveglfevsmvihsydddvtek.lsllhystwpqngvpqspvhvgh
subfamily_PTPN12_pd Subfamily PTPN12 819-1028 1.2e-09 32.4 In-house 71-282 (290) alignment 
Range on Protein: 819-1028
Range on HMM: 71-282/290.0
FTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLS----PTDADTYSYISEFGTTGLKFGAITISVGRKKEFNAGFLTRDINIRNEEDSM
  | .. |   .  .| .  |  .  . |||.|..|. . .. .             | .| | . |.||...... ..| .. .|| | ........| 
inanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesr

llRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVEschHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERI---INILQAANHHYLQSPGLIVNLQF
  .|. ..|..   . .  .... ...|.      |   . ..|...|     |  |.  .. |  .  |.|.|   ... .   .   | . |.   . 
..kvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeq

YAYCYDCLMEYSNKLLK
| . | ...|. .| |.
yelvykavaelvqkele
PTEN_1 649-712 1.5e-09 32.9 In-house 86-149 (196) alignment 
Range on Protein: 649-712
Range on HMM: 86-149/196.0
DRGKKERTILQFHYITWPNKNVPAQAShVLDFMRAINSANDSKEC-GPVVVHCSAGVGRTGTIIA
|  . ..  .... . ..  ..|  .. ..|. . . ..  |... . |.||| ||.||.||..|
dleeffksgveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 815-1022 1.6e-09 31.9 In-house 69-292 (301) alignment 
Range on Protein: 815-1022
Range on HMM: 69-292/301.0
EETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFGTTGLKFGAITISVGRKKE---------------
...   | |.|||   . || .  | |     |||||...| ..|. .  .. .    .. | ..  ..  .|| .|. .  ..                
qreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqd

-FNAGFLTRDINIRNEEDSMllRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESchHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQA
 .| |.. | ...... .|.   |  .|  |       .     .. |.  . .  .   |  |.. |   . .  |.. ...  |  .| | .... | 
gsnngyierkfkvksdkssw..dvlqlqvtdWpqdGvvreprtvLqviddvihrqqk..igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqv

ANHHYLQSPGLIVNLQFYAYCYDCLMEY
 .    . || .  |. |   || . .|
tkavrrskpgaVtTLeqytsiydvidmy
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 820-1027 2.7e-09 31.6 In-house 73-280 (281) alignment 
Range on Protein: 820-1027
Range on HMM: 73-280/281.0
TAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP----TDADTYSYISEfGTTGLKFGAITISVGRKKEfNAGFLTRDINIrNEEDSML
 | ...||  .. .| .  |  .  . ||.... .| | |. .           . |  . ... ||.| .|..  ...| .| ...| ... ..|..  
nanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPd.dnselkygdvtvkstaeee.katyierkfkl.eresget

LRVKYIQYQDmFLKHCFPRVDkfMKFIQYCL-VQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKE-RIINIlQAANHHYLQSPGLIVN-LQFY
 .|. ..|.  .  |  |     ......   |.  . .. ..|...|     |  | . .|   ......| . ... .|  ..  ..  |.|  .  |
reveqlayta.WPdhGvPatt..kellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldv.kavvaelrkernlmvqtvvqy

AYCYDCLMEYSNKLL
.. |  .... .| |
efvykavldaldkel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 527-568 2.9e-09 30.8 In-house 45-86 (440) alignment 
Range on Protein: 527-568
Range on HMM: 45-86/440.0
EYDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINANYIKGY
  .. |||...| |.||.||.|.|  |||.|.|||| ||.| 
pnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_PTPN23_pd Subfamily PTPN23 833-1027 5.3e-09 30.3 In-house 85-284 (288) alignment 
Range on Protein: 833-1027
Range on HMM: 85-284/288.0
FIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADT----YSYISEFGTTGLKFGAITISVGRKKEFNaGFLTRDINIRNEEDSMLLRVKYIQYQDmFL
|| .  | .     ||... ..| | |. |   ..       .|  |      |||...... ...| .  .  |..... .. .    |...|..  . 
fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvrete.thvervlkletldadavksvshlqlts.Wp

KHCFPR-VDKFMKFIQYCLVQ-VESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRA-KKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEYSNK
..  |   .....|..    .  .  .. . |...|     |  |.|| .   ..   |.. ...|.|  ..   |    . . . .  .|.  .|. ..
elGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

LL
 |
vl
0051082 (Phosphotyrosine protein) phosphatases II 821-1019 6.7e-09 31.0 In-house 8-149 (151) alignment 
Range on Protein: 821-1019
Range on HMM: 8-149/151.0
AHYLDGYwtpnlFIKSPCPtkdnTECFWRLIIHKKCSHIINLSPTDADTySYISEFGTTGlkfgaitisvgrkkefnagfltrdinirneedsmlLRVKY
..|..|.     .. | .|    .. |..|. . ....|.|| ...     . . .  .|                                   ..|..
fsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg...................................ievlh

IQYQDMFLKHCFPRVDKFMKFIQYCLVqveschHGNHPILMHDDGSNGPIGIFATLTYCLQRakkeriINILQAANHHYLQSPGLIVNLQFYAYCYDCL
|.. |.    .    | ...|....|       ..|.|.|.|  .  |  |... |  .|..      ... .| ..  |. ||..   | . ... .|
ipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 528-679 8.1e-09 28.5 In-house 25-162 (169) alignment 
Range on Protein: 528-679
Range on HMM: 25-162/169.0
YDHTKNRFKDIGAFDHTRVVLQETPGVPHSHYINAnyikgyyddklyiatqypsketcdnfwRMVWEQKTVTIVMLTNVVDSFKYWPSDDE------VC-
 . ||||     |  |||| ||       | ||||                           ||.||  .  ||.| .  |   .||  ..      |  
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavil

---YGD-IVVRADRNIELPNYVIRGFKVFNKRDRGKKERT--ILQFHYITWPNKNVPAQASHVLD
   | | . ||.|.     . |   |.|    .. ... |  .  .|| |||.. ||    ||  
Gewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvgh
subfamily_PTPDC1_pd Subfamily PTPDC1 659-749 1.8e-08 29.0 In-house 84-165 (182) alignment 
Range on Protein: 659-749
Range on HMM: 84-165/182.0
QFHYITWPNKNVPAqASHVLDFMRAINSANDSKecgPVVVHCSAGVGRTGTIIALDIALeqlksENRVDIEGIVKVLRQQRTQMVQELCQF
 .. ..|.. .|..   ..|| .. ...| . .    | ||| || |||| .||  .        .|.. |  .|..|..|.. .|   | 
yvynfgwkDygvas.leriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvy.....akrltaekaiklvrskrpksiqtreqv
0046846 (Phosphotyrosine protein) phosphatases II 825-1024 2e-08 29.7 In-house 17-174 (176) alignment 
Range on Protein: 825-1024
Range on HMM: 17-174/176.0
DGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTD-------ADTYSYISEFGTtglkfgaitisvgrkkefnagfltrdinirneedsmllR
....  ...|    |. .... |.... . ......||           .. .... ..|                                       .
anlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................................q

VKYIQYQDMFLKHCfPRVDKFMKFIQYCLVQveschhgNHPILMHDDGSNGPIGIFATLTyclqRAKKERIINILQAANHHYLQSP-GLIVNLQFYAYCY
....   |.        ......||. .| .       ..|.| |  .  |  | .. .       ..|. .....|  .   | | | . . ..| ..|
ylhlpwpDhgvpdl.elllellefirealke.......ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrfly

DCLMEYSN
...... .
efellllk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 819-1018 2.5e-08 28.4 In-house 32-234 (237) alignment 
Range on Protein: 819-1018
Range on HMM: 32-234/237.0
FTAHYLDGY-WTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP----TDADTYSYISEFGtTGLKFGAITISVGRKKEFnAGFLTRDINIRNEEDS
  | ||.|.  ||. .| .  | .   . ||...  .||| |. |.      .   . |  .       .| .|.|. .|.|| . .  | . . ..   
inatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaaygvltvslkkkeef.sdytvrslllskrltl

MLLRVKYiQYQ-DMFLKHCFPRVDK-FMKFIQYcLVQvESCH-HGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQ
  .|. . |||   . ..  |.    ...| .  ... .| |     | ..|     |  |||  .   |..||......| .       . | .|   .
kevrlih.qyqftswpdrgvpqqtaallrfrkn.iin.rsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkd

FYAYCYDC
 | . .. 
qyvfihqt
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 818-1027 2.7e-08 28.2 In-house 59-272 (274) alignment 
Range on Protein: 818-1027
Range on HMM: 59-272/274.0
MFTAHYLDGYW-TPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDAD----TYSYISEFGTT--GLKFGAITISVGRKKEFNaGFLTRDINIRNE
   | |. ||  . . ..    |     . |||.| ..... |. |             |  .   .    ..| . | |  ..| | ..  | . ... 
yinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekivern.dysvrklvlkyl

EDsmLLRVKYIQYQDMFLKHCFPRVDKFMKFIQYCLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQ
|.    .||.. | |   ..   ..........    . |. ..   |...|     |  |.| . . .... ..| ....|.   .  |.  |.. . .
er..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtse

FYAYCYDCLMEYSNKLL
 | . .  |..| ..||
qyelihralclylkrll
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 532-608 2.9e-08 27.6 In-house 37-112 (332) alignment 
Range on Protein: 532-608
Range on HMM: 37-112/332.0
KNRFKDIGAFDHTRVVLQETPGvpHSHYINANYIKGYYDDKLYIATQYPSKETC-DNFWRMVWEQKTVTIVMLTNVVD
 ||   . .|||.|| |    |  .  . ||... ||     || .| | ..     ||||| |.|   |... .. .
mnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdide
Death Death domain 45-111 3.3e-08 21.3 Pfam-A 17-80 (83) alignment 
Range on Protein: 45-111
Range on HMM: 17-80/83.0
ELGLYLQLHDNTLKSIEQEYRGkVDRCFIECLGSWLRKadDVENPTIDTLIVALRGMGENAVADGIN
||.  |.| ......||.|... .     | | .|  .    .| |...|. ||| .| . .|. ..
eLarkLglsedeideiesenpr.lreqtyelLqlWeqr..egknatlgaLleaLrklgrrdaaekle
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 650-760 5e-08 25.9 In-house 199-309 (346) alignment 
Range on Protein: 650-760
Range on HMM: 199-309/346.0
RGKKERTILQFH-YITWPNKNVPAQASHVLDFMRAINSANDSKECGPVVVhCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQ
 |. .  | | | .  |   . | ..  .. ..  . | .. .. |  ||    | ||. ..|    |..||      .|  |.| ..|||   |. . |
egnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaq

FVFIYNAVLEDI
.  ||  |.. |
yasiyaivfdyi
0049260 (Phosphotyrosine protein) phosphatases II 823-1017 7.6e-08 27.7 In-house 1-144 (152) alignment 
Range on Protein: 823-1017
Range on HMM: 1-144/152.0
YLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTYSYISEFGttglkfgaitisvgrkkefnagfltrdinirneedsmllRVKYIQ
..|||. |. ||    |.  ... |||.. . ....|..|   . ... .  .                                         ......
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.......................................qylhlp

YQDMFLKHCFPRVDKFMKFIQYClvqvesCHHGNHPILMHDDGSNGPIGIFATLTYCLqrakkeRIINILQAANHHYLQSPGLIVNLQFYAYCYD
  |.        .. ...||. .      ... ..|.| |  .  |  | .. . ..|      . .....| ..   . || . | ... ..|.
wpDhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 818-1027 9.5e-08 26.3 In-house 50-268 (270) alignment 
Range on Protein: 818-1027
Range on HMM: 50-268/270.0
MFTAHYLDGYW-TPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSPTDADTY----SYISEF--GTTGLKFGAITISVGrKKEFNAGFLTRDINIRne
 . | |. |.   .. .| .  |..  .. |||.|...| . |. ...   .       | ..    .. |..| |.. .  ..| . |.... ....  
YinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlal.seekeegyiltrlrle..

EDSMLLRVKYIQYQDmFLKHCFPRVDK-------FMKFIQYCLVQVESCHHGNhPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSP
|..   |.   .|.. .  |  || .         .| ..    . .. .... |.|.|.    |  |.. .| ....  .... ...|.  ..   . .
ekgeerrlvHfwynt.Wpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRm

GLIVNLQFYAYCYDCLMEYSNKLL
 |.   . |.. |  ..|| ....
alvqhpeqyeflykavveyaerra
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 661-751 1.1e-07 25.7 In-house 233-329 (347) alignment 
Range on Protein: 661-751
Range on HMM: 233-329/347.0
HYITWPNKNVPAQASHVLDFMRAINSAN-D-----SKECGPVVVHCSAGVGRTGTIIALDIALEQLKSENRVDIEGIVKVLRQQRTQMVQELCQFVF
   ||| |. | .  .|| ..||             .   |||| |  |. |. |..   | .||. . .  | . . | .|.||. .      . .
ncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifyty
subfamily_DSP23_pd Subfamily DSP23 661-743 1.5e-07 26.2 In-house 55-129 (148) alignment 
Range on Protein: 661-743
Range on HMM: 55-129/148.0
HYITWPNKNvPAQASHVLDFMRAINSANDSKECgpVVVHCSAGVGRTGTIIALDIALEQlkseNRVDIEGIVKVlRQQRTQMV
. .  ..   |     | .|.| .. |.. .|   | |||  | |||||..|  .  |.    .    | | .| |..|   |
vrlriddyh.ppaleqvvefvrvveeaeeknea..vsvhcllgrgrtgtmlacylvker....klaaaeaiaev.rrlrpgsv
PTPc_motif_SM00404 650-750 1.8e-07 26.1 In-house 42-131 (140) alignment 
Range on Protein: 650-750
Range on HMM: 42-131/140.0
RGKKERTILQFHyIT-WPNKNVPAQASHVLDFMRAInsandSKECGPVVVHCSAGVGRTGTIIALdialEQLKSENrVDIEGIVKVLRQQRtQMVQELCQ
. .....|||   .    .... .. . ||||....      |. | |.||| ||| |..|.|.     . ..... ....  .......| .....  .
kensgfqilqip.lddnekdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSatliia....Ylmryrq.lslaeayefvkerR.piispnln

FV
||
fv
PTPc_DSPc_SM00012 918-1021 2e-07 26.5 In-house 5-105 (105) alignment 
Range on Protein: 918-1021
Range on HMM: 5-105/105.0
VKYIQYQDMflkhCFP-RVDKFMKFIQYCLVQVESCHHgNHPILMHDDGSNGPIGIFATLTYCLQRAKKE-RIINILQAANHHYLQSPGLIVNLQFYAYC
..| ...|.    . | ..|.........  . . . . ..|.. |.    |  |.|..| ..||. .|| . ..|.|  ..   | ||.. ... | ..
yhytgwpdh....gvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YDCLME
|..|.|
yralle
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 554-626 2.3e-07 25.2 In-house 10-84 (130) alignment 
Range on Protein: 554-626
Range on HMM: 10-84/130.0
VPHSHYINANYIKGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSFKYWPSDDEVC-Y-GDIVV
..  .||||...      . |. || |  .|. .||.|. |.    .|.|  | .  .|||  . .  |  ||.|
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyeediiv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 566-626 5.7e-07 23.2 In-house 230-293 (440) alignment 
Range on Protein: 566-626
Range on HMM: 230-293/440.0
KGYYDDKLYIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDS--FKYWPSDD-EVCYGDIVV
.||   . .|||| |   |  .|||.| . .  ||.|| .. |     ||| .   | .| . |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 817-1002 7.4e-07 23.1 In-house 82-265 (290) alignment 
Range on Protein: 817-1002
Range on HMM: 82-265/290.0
TMFTAHYLDGywTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP----TDADTYSYISEFGTTGLKFGAITISVGRKKEFNAGFLTRDINIRNEED
    | |..|  .   || .  ..|| .  .||.....| . |. |        |    |  |     | ||.||.    ... .|    . . .|. ..
dyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkds

SMLLRVKYIQYQdMFLKHCFPRVDkfMKFiqycLVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQR---AKKERIINILQAANHHYLQS
    ..|... .  .  .. .  .  . .    |  . .  . . |. .|     |  | |...  .||     |. ..... .|  .  |.|
Gkehklkhlkik.swpdksvalst..lal....lrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlns
0044763 (Phosphotyrosine protein) phosphatases II 830-1022 8e-07 24.4 In-house 28-170 (178) alignment 
Range on Protein: 830-1022
Range on HMM: 28-170/178.0
PNlFIKSPCPTkdntECFWRLIIHKKCSHIINLSPTDA------DTYSYISEFgttglkfgaitisvgrkkefnagfltrdinirneedsmlLRVKYIQY
|. .. ...|.    .....|.   ...||.||....       | | . ..                                        .....| .
pg.lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipi

QDMFLKHCFPRVDKFMKFIQYCLvqvescHHGNHPILMHDDGSNGPIGIFATLTYCLQRakkeRIiNILQAANHHYLQSPgLIVNLQFYAYCYDCLMEY
 |.     .  ...|..||. .|      .  ..|.| |     |  | .. . .....    .. .. .| ..   . |  . |  .. ..|.. ...
pDhgvpdllehflefvefieeal......dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrl
0048567 (Phosphotyrosine protein) phosphatases II 652-713 9e-07 23.4 In-house 25-97 (157) alignment 
Range on Protein: 652-713
Range on HMM: 25-97/157.0
KKERTILQF------HYITWPNKNVPAQASHVLDFMRAINSAND--SKECGPVVVHCSAGV---GRTGTIIAL
|.  . |.|      .|...  .. |   ... .|.. .|.  .  ... ....|||.||    |||.|.|..
kslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 812-1036 1.1e-06 22.4 In-house 69-247 (392) alignment 
Range on Protein: 812-1036
Range on HMM: 69-247/392.0
DYGEETMFTAHYLDGYWTPNLFIKSPCPTKDNTECFWRLIIHKKCSHIINLSP-TDADtysyisefgttglkfgaitisvgrkkefnagfltrdiniRNE
|  ..  . | |.... . . .| |  |     . |||.. ... . |. ..   ..|                                       . .
dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......................................kgd

EDSMLLRVKYIQYQDMF-LKHcfprVDKFMKFIQYCLVQVESChhgNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNL
..    . .. .. |    ||    .  ..|||.   ..  .     ||...|     |  |.  ..   . .||| |......       . | ..   
dartvaqfhftewPdkdvpkh....tssllkfikevkadfGqy...thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtk

QFYAYCYDCLMEysNKLLKEEYFPSIH
. ||. | ...|  . | ..   | .|
eqyafiygavle..dllwrntlipvvh
subfamily_PTPN14_pd Subfamily PTPN14 833-1024 1.2e-06 22.7 In-house 95-297 (300) alignment 
Range on Protein: 833-1024
Range on HMM: 95-297/300.0
FIKSPCPTKDNTECFWRLIIHKKCSHIINLSPT----DADTYSYISEF--GTTGLKFGAITISVGRKkEFNAGFLTRDINIRNEEDSMLLRVKYIQYQDM
.| .  | .   . ||...  .. . |. |  .       ...|. .       ..||   ..   . |    . |. ....    .    | ..||.| 
yivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfs.edsdsvittglklkhlpskeertvwhlqytDW

FLKHCFPRVDKFMKFIQYC------LVQVESCHHGNHPILMHDDGSNGPIGIFATLTYCLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLM
  ... . |..|.....          .  . .. . |.|.|     |  |.  .    ..  .... |.| .. ..   |   |. .|  | . |. |.
pdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli

EYSN
.| .
kylk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 574-627 1.9e-06 21.7 In-house 139-194 (244) alignment 
Range on Protein: 574-627
Range on HMM: 139-194/244.0
YIATQYPSKETCDNFWRMVWEQKTVTIVMLTNVVDSFKYWPSDDEVCY--GDIVVR
|| ||.|  .|  .||.|. |..   .|.|  | .  .|||  . . .   || | 
yiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpdseplewyeeditvt
0049772 (Phosphotyrosine protein) phosphatases II 816-1028 2.7e-06 22.8 In-house 72-285 (314) alignment 
Range on Protein: 816-1028
Range on HMM: 72-285/314.0
ETMFTAHYLDGYwtpNLFIKSPCPTKDNTECF----------WRLII-HKKCSH--------------------------------IinlsptDADTYSY
  ...| |.||.   . || .  |.. . ..|          ||...  .  ..                                       .  | ..
sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng......neptaad

ISEFGttglkfgaitisvgrkkefnagfltrdiN---IRNEEDSMLLRVKYIQYQDmFLKHCFPRVDKFMKFIQYClvqveschHGNHPILMHDDGSNGP
. ..                             .    ..    . .....|   | .    .  .|.|..||. .        . ..|.|.|  .  | 
lellk............................eelydpelferlgikylripvpD.gsaplledfdeflefieea........dkggpvlvHCkaGkgR

IGIFATLTYCLQ--RAKKERIINILQAANHhYLQSPGLIVNLQFYAYCYDCLMEYSNKLLK
 | |... |..   .   | ... ...... .  .||.| .|. | .....|.|| ..|.|
tgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkflkk
subfamily_PTEN_pd Subfamily PTEN 641-742 3e-06 22.4 In-house 61-162 (184) alignment 
Range on Protein: 641-742
Range on HMM: 61-162/184.0
GFKVFNKRDRGKKERTILQFHYITWPN-KNVPAQASHVLDFMRAINSANDSKECGPVVVHCSAGVGRTGTIIALDIaLEQLKSENRVDIEGIVKVLRQQR
 .|..| |   | . . .. . ...|   . |.. . . .... |..  ....   ||||| || ||||..|.  . |..|. |.  ..  . .  | . 
hykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayl.lkslllekaeealelfaeaRtkn

TQM
.. 
kkg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 498-568 4.3e-06 20.5 In-house 10-77 (244) alignment 
Range on Protein: 498-568
Range on HMM: 10-77/244.0
NNQEMFKEIFESINSTSPDYKCDATLMAQeyDHTKNRFKDIGAFDHTRVVLQETPgVPHSHYINANYIKGY
...|. || | ...  . ..    ....   . ||||. .|  ||.|||.|  .     | |||||||.| 
qdeevakeefvglsdhtreflqtnavlsa..natknryinilpfdetrvilsssk.kegsdyinanyiqgs
subfamily_CDC14_pd Subfamily CDC14 680-715 6.8e-06 20.1 In-house 255-285 (328) alignment 
Range on Protein: 680-715
Range on HMM: 255-285/328.0
FMRAINSAndskeCGPVVVHCSAGVGRTGTIIALDI
|......|      | ..||| ||.|||||.||  .
fleiaeka.....eGaiavhCkaGLGrtGtLiacyl
DSPc Dual specificity phosphatase, catalytic domain 669-713 7.5e-06 20.8 Pfam-A 54-93 (133) alignment 
Range on Protein: 669-713
Range on HMM: 54-93/133.0
NVPAQASHVLDFMRAInsandSKECGPVVVHCSAGVGRTGTIIAL
.. .. . . .|....      .. . |.||| ||. |..|.|. 
kiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliia
DSPc Dual specificity phosphatase, catalytic domain 669-713 7.5e-06 20.8 In-house 54-93 (133) alignment 
Range on Protein: 669-713
Range on HMM: 54-93/133.0
NVPAQASHVLDFMRAInsandSKECGPVVVHCSAGVGRTGTIIAL
.. .. . . .|....      .. . |.||| ||. |..|.|. 
kiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliia
subfamily_PTPN13_pd Subfamily PTPN13 881-1022 7.7e-06 20.4 In-house 131-268 (273) alignment 
Range on Protein: 881-1022
Range on HMM: 131-268/273.0
LKFGA-ITISVGRKKEFnAGFLTRDINIRNEEDSMLLRVKYIQYQDmFLKHCFPRVD-KFMKFIQYclvqVESCHHGNHPILMHDDGSNGPIGIFATLTY
||    ..... . ..   ||  |...... | .   .|  ... . .  |  |.   ....|...    | . .. . ||..|     |  |.. |.  
lkvsnrlevellkvqkl.dgfvvralavkdsesgesrevahlnfvk.wPdhgvPssaaellqfvae....vrrlqtdagPivvhcsaGiGrsGtlitidv

CLQRAKKERIINILQAANHHYLQSPGLIVNLQFYAYCYDCLMEY
 |.  .... ... .  ..   |  |..   . | ..|  ..| 
vlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev