Gene PTPRD-50 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP107_AA protein Get Run
AqueP107_AA_5-219 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 9-226 1.7e-115 379.8 In-house 67-301 (301) alignment 
Range on Protein: 9-226
Range on HMM: 67-301/301.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDC--------------
. .. |||||.  ||.||..||.||.||..|..|||..|...|...|||.....|. ...|.|||..|.. |  ....... ....              
lcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvki

-----NGYIERKFNVHSDKgsSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQV
     ||||||||.|.|||  |||.|.|.|||.||||||..||||||||||.||||||||||||||||||||||||||||||||.|||||||||||||||
qdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqv

TKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYAN
||.||||||||||||.||.|||.||.|||.|.|||||
tkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 9-221 1.9e-89 294.8 In-house 68-286 (305) alignment 
Range on Protein: 9-221
Range on HMM: 68-286/305.0
QE---SHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTI--SFGEYFIKCLSSKDCNGYIERKFN
.|    . |||||.  ||..| ..|.||.|..|||.|||..||..||| ||||... |.|...|.||| || |    |||. ..  |.|  ..|||||..
keslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklk

VHS-DKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVT
.   |. . | .|.|.|.|.||..|| ... ..|..|..| ..|.|  | |..||||..|.|.||...|.||||..|.|.|||||.|.| .|......|.
isiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvq

TLDQYSSIYEVISMYLKLH
||||| ......  ...  
tldqYvflhdaldelitcg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 6-227 6e-83 273.1 In-house 65-287 (287) alignment 
Range on Protein: 6-227
Range on HMM: 65-287/287.0
VVSQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVH
.. .| . ||||.|  ||.||.|||||.||| ||.|.|||.| | .|.||||||  .|. .| ||||| |......||| |. |. .  .||||||..|.
llkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevk

SDK-GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
 ..  ..  .|.|.|.|||.. | ..||.|.| ||.| .. |.| | ...|||||||| ||...|.. .....|| |||.||||| || |  |||.| | 
nknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtv

DQYSSIYEVISMYLKLHSTYANF
.||  |.... .||.  .||..|
eqykfindivleyldsfetysdf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 11-224 6.4e-81 266.4 In-house 75-289 (290) alignment 
Range on Protein: 11-224
Range on HMM: 75-289/290.0
SHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSDKG-
.. ||||..  ||.||...|..|.|..||..||||.|.. ||..||||.   |.|.. |.||| .||| ..||. || |. . .|.|||||..|....  
tneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa

SSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSS
 .. .|.|.|.|||...| ...| |.|.|| |... | | | ...||||||||.||.|.|.. .....|| |||.||||| || |  ||| |.| .||  
gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqg

IYEVISMYLKLHSTY
|....  ||.  .||
ifqivltyldsfety
0050432 (Phosphotyrosine protein) phosphatases II 6-226 1.3e-71 236.8 In-house 85-307 (308) alignment 
Range on Protein: 6-226
Range on HMM: 85-307/308.0
VVSQESHGYINASFTAGY--REKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES---DTISFGEYFIKCLSSKDCNGYIER
|. .|...|||||.  ||  . .|.||..|.|..||| |||.|. ...|. ||||. ..|.|.| |.||| ..   ... .| .....|| . ...|. |
VkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvr

KFNVHSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQqkiGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGA
.. .   ... |  |..|. |||| .||  .|. .|. ...| ...   .|||.|||||. |.|.|... . ..||| ..|| ||||.. | .|. .||.
tleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgm

VTTLDQYSSIYEVISMYLKLHSTYAN
|.|..||  .|... .||||. |..|
vqtpeqylflyralleylklkltkln
0036941 (Phosphotyrosine protein) phosphatases II 8-223 3.2e-69 228.8 In-house 59-282 (297) alignment 
Range on Protein: 8-223
Range on HMM: 59-282/297.0
SQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES--DTISFGEYFIKCLSSKD--CNGYIERKFN
..|...|||||.  ||. ||.||..| |..||| |||.|. ...|. ||||.  .|.| | |.||| .   ... .|......|| .   ...|. |.. 
ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtle

VHSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALEQCK---AEGVVDVFQVTKSVRRSKPG
|   ... |  |..|..|.|| .||   |...|. |..| ...... .||||.||||. |.|||... . ..|.| .    || ||.... |..|. .||
vtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg

AVTTLDQYSSIYEVISMYLKLHST
||.||.||  .||.. ..|| . |
avqtleqyrflyeallellkkklt
subfamily_PTPRD_pd Subfamily PTPRD 8-224 4.4e-69 228.6 In-house 72-287 (564) alignment 
Range on Protein: 8-224
Range on HMM: 72-287/564.0
SQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSD
 .|.  ||||||  |||...|.| .| |...|..|||.|. ....| ||||  .|| |.. | .|| |..| ..||. ..  .... . |. |.|...  
gdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkk

KGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQY
| |.| .| ||. |.||. || ......|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. | .|. ..  | | .||
kssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQY

SSIYEVISMYLKLHSTY
. |.|.|  .|.  .| 
iFiheailealacgnte
0051299 (Phosphotyrosine protein) phosphatases II 9-219 8.9e-69 227.4 In-house 74-287 (288) alignment 
Range on Protein: 9-219
Range on HMM: 74-287/288.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSD-
.|...|||||.  ||. ||.||..| |..||| |||.|. ...|. ||||....|.|.| |.||| ..... .|......|| . ...|. |.. |    
vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnld

---KGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
   ... | .|..|..|||| .||   |. .|. . .|.. ..  ||||||||||. |.|.|... . ..||| ..||.|||... | .|. .||.|.|.
lldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

DQYSSIYEVISMYLK
.||  .||.. .|||
eqyrfvyealleylk
0040438 (Phosphotyrosine protein) phosphatases II 10-224 3.7e-68 225.5 In-house 69-282 (317) alignment 
Range on Protein: 10-224
Range on HMM: 69-282/317.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSDKG
....|||||.  |...||.||..|.|..||| |||.|. ...|. ||||. .||.|.| |.||| . .|. .|......|| . ..|.. |.. |  ...
ldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgd

SSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQkiG-GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYS
| |  |..|. |.|| .|| . |...|. ...| . ..  . ||||.||||. |.|.|... . ..|||.. || |||... | .|. .||||.|..|| 
sesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyr

SIYEVISMYLKLHSTY
 .|... .||| . |.
flydalleylkrkltl
0046845 (Phosphotyrosine protein) phosphatases II 10-226 3.9e-68 225.2 In-house 55-282 (284) alignment 
Range on Protein: 10-226
Range on HMM: 55-282/284.0
ESHGYINASFTAGY-----REKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESD-TISFGEYFIKCLSSKDCNGYIERKFN
|...|||||.  ||     . |..||..| |..||| |||.|. ...|. ||||....|.|.| |.||| ... .. .|......|| . ...|. |.. 
edsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtle

VHSDK-GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQK-IGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEG---VVDVFQVTKSVRRSKP
.   . .. |  |..|..|.|| .||  .|. .|. ...| . ...  ||||.|||||. |.|.|... . ..||| ..||   .|||... | .|. .|
ltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp

GAVTTLDQYSSIYEVISMYLKLHSTYAN
|.|.||.||  .||.. .||||. |...
gmvqtleqyrfvyealleylklkltlle
0047943 (Phosphotyrosine protein) phosphatases II 8-218 1.4e-67 223.4 In-house 58-272 (273) alignment 
Range on Protein: 8-218
Range on HMM: 58-272/273.0
SQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESD---TISFGEYFIKCLSSKDCNGYIERKFNV
......|||||.  ||. ||.||..| |..||| |||.|. ...|. ||||. ..|.|.| |.||| ..    .. .|......|| . ...|. |.. .
gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtlel

HSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
 . . . |  |..|..|.|| .||   .  .|. |..| . .... ..||||||||. |.|.|... . ..|.| ..|| |||... | .|. .||.|.|
tnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqt

LDQYSSIYEVISMYL
..||  .||.. .||
peqyrflyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 9-225 4.1e-67 221.5 In-house 81-297 (298) alignment 
Range on Protein: 9-225
Range on HMM: 81-297/298.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSDK
.|   ||||||  .|... |||..| |...|| |||.|........||||  .|| ..  . .|| .. .  .||  .. ||...   .| ||..|.. |
deesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkk

GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYS
 ... .| |...|.||. || .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| | .|...||||.| .||.
eekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYv

SIYEVISMYLKLHSTYA
 |||..  .|.  ....
fiyeavlealdsfndei
0043336 (Phosphotyrosine protein) phosphatases II 10-218 7.9e-65 214.4 In-house 71-277 (278) alignment 
Range on Protein: 10-218
Range on HMM: 71-277/278.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWReSDTISFGEYFIKCLSSKDCNGYIERKFNVHSDKG
....|||||.  ||. .|.||..| |...|| |||.|. ...|. ||||.. .|.|.. |.|||  .... .|......|. . ...|. |...|.  . 
ldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgd

SSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSS
. |  |.... ..|| .||   . ..|. . .|.....   .|||.||||. |.|.|... . ..||| . || ||.... | .|. .||||.|..||  
gesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf

IYEVISMYL
.||.. .||
lyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 10-222 9.1e-65 214.4 In-house 83-293 (297) alignment 
Range on Protein: 10-222
Range on HMM: 83-293/297.0
ESHGYINASFTAGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQeCCYQYWRESDTiSFGEYFIKCLSSKDCNGYIERKFNVHSdk
... |||||.  ||.  .|.||..| |...|| |||.|. ...|..||||. ..|.|. .|.||| |. .  .|......|. . ..||. |...|    
ldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..

GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQY
.. |  |..||.|.|| .||   ....|.....| .....  .||||.||||. |.|.|...   ..|||.. || |||... | .|. .||||.|..||
ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy

SSIYEVISMYLKLHS
  .|... ..|| . 
rflydallellkrkl
Y_phosphatase Protein-tyrosine phosphatase 9-214 1.4e-64 213.1 Pfam-A 24-233 (235) alignment 
Range on Protein: 9-214
Range on HMM: 24-233/235.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ESDTISFGEYFIKCL-SSK-DCNGYIERKFNV
.... ||||..  ||.||..||..| |...|. |||.|....||..||||.  || |.| | |||   |... ..|......  ..| |...|. ||...
egpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklel

HSDKGSS-SWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
...|..| .  |.|...||||. || ..|. .|..|..| ... .   ||||||||. |.|.|......|.|||..||. |||.|. |..|...||.|..
kkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqs

LDQYSSIYEVI
|.||  .|..|
leqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 9-214 1.4e-64 213.1 In-house 24-233 (235) alignment 
Range on Protein: 9-214
Range on HMM: 24-233/235.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ESDTISFGEYFIKCL-SSK-DCNGYIERKFNV
.... ||||..  ||.||..||..| |...|. |||.|....||..||||.  || |.| | |||   |... ..|......  ..| |...|. ||...
egpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklel

HSDKGSS-SWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
...|..| .  |.|...||||. || ..|. .|..|..| ... .   ||||||||. |.|.|......|.|||..||. |||.|. |..|...||.|..
kkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqs

LDQYSSIYEVI
|.||  .|..|
leqYiflykai
DSPc_SM00195 10-218 1.6e-64 213.2 In-house 52-262 (263) alignment 
Range on Protein: 10-218
Range on HMM: 52-262/263.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES--DTISFGEYFIKCLSSKDCN-GYIERKFNVHS
|.. ||||..  |...|...|..| |...||.|||.|... ||. ||||.  ||.|.| |..|| |.  ..  ||.. .|. . . ..  .| |....  
egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltk

DKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQ
.. . . .| |.|..|||. || .... ||... .| ......  ||.|||||. |.|.|......|.|.....|  ||.|.. |..| ..||.|.||.|
egkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq

YSSIYEVISMYL
|. |||.|  |.
Ylfiyeaileyi
PTPc_SM00194 10-218 1.6e-64 213.2 In-house 52-262 (263) alignment 
Range on Protein: 10-218
Range on HMM: 52-262/263.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES--DTISFGEYFIKCLSSKDCN-GYIERKFNVHS
|.. ||||..  |...|...|..| |...||.|||.|... ||. ||||.  ||.|.| |..|| |.  ..  ||.. .|. . . ..  .| |....  
egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltk

DKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQ
.. . . .| |.|..|||. || .... ||... .| ......  ||.|||||. |.|.|......|.|.....|  ||.|.. |..| ..||.|.||.|
egkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq

YSSIYEVISMYL
|. |||.|  |.
Ylfiyeaileyi
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 9-225 1.9e-64 212.3 In-house 34-249 (250) alignment 
Range on Protein: 9-225
Range on HMM: 34-249/250.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQEcCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSDK
..   ||||||  ||.|..|||..|.|...|. |||.|....|...||||   .| ... . |||    .  .|.  .. ||..    |. ||. . . |
dkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllskeefadytkrklklskak

GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYS
 ...  | |.. ..||  || .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | | |||||.| | .|. .|.||..|.||.
kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyv

SIYEVISMYLKLHSTYA
..||.|  .|.  . ||
fvyeiilkaldsvedya
0045450 (Phosphotyrosine protein) phosphatases II 10-218 2.7e-64 213.1 In-house 82-304 (307) alignment 
Range on Protein: 10-218
Range on HMM: 82-304/307.0
ESHGYINASFT--------AGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES-DTISFGEYFIKCLSSKDCNGYIER
|...|||||.          ||. ||.||..|.|...|| |||.|. ...|..||||....|.|.| |.||| .. ... .|......|| . ..||. |
edsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvr

KFNVHSD-KGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRR
...|.   . . |  |..|. |.|| .|| . . ..|. |.|| . ...  .||||.||||. |.|.|...   ..|.| ..||.   ||.... | .|.
tlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllre

SKPGAVTTLDQYSSIYEVISMYL
 .||||....||  .||.. ..|
qRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 9-226 3e-63 208.8 In-house 71-288 (318) alignment 
Range on Protein: 9-226
Range on HMM: 71-288/318.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSDK
.|.  ||||..  |||.|.|.| ||.|. .|..|||.|. . . . ||||  .|| |.. . .|| .....|.|.  ..  ...... |. |.|.|. ..
eegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrte

GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYS
 ..| .| |...|.||. || ... ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | ||| 
eeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqye

SIYEVISMYLKLHSTYAN
 ||.|.  .|.   |...
fiydvllealasgdtevd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 9-223 5.5e-63 207.9 In-house 73-288 (319) alignment 
Range on Protein: 9-223
Range on HMM: 73-288/319.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSDK
.|.  ||||||  ||.|...|| .|.|.|||. |||.|. ....| .|||..  | ..  . .|| | .  ..|.. .. .. .  ..|| ||....  .
vegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkks

GSS-SWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQY
.   . .|..|| |.||...| .. ...|... .. . ..|   ||.|||||. | | | .. ....||. | |||.|||.. . .|  ..  | . .||
sevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqY

SSIYEVISMYLKLHST
. |||..  ...  .|
kfiyealleaveagdt
0040439 (Phosphotyrosine protein) phosphatases II 10-218 6.6e-63 207.9 In-house 37-246 (249) alignment 
Range on Protein: 10-218
Range on HMM: 37-246/249.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSDKG
. ..|||||.  ||. ||.||..| |...|| |||.|. ......||||. ..| |.| |.||| ..... .|......|| . ...|. |.. ..  . 
flsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlyd

SSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYS
..|  |...|.|.|| .|| . . ..|. |..| . ....  ||||.||||. |.|.|...   ..||| . |. ||.... | .|. .||||....|| 
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr

SIYEVISMYL
 .||.. ..|
flyeallell
0042113 (Phosphotyrosine protein) phosphatases II 11-218 6.4e-61 201.2 In-house 36-243 (245) alignment 
Range on Protein: 11-218
Range on HMM: 36-243/245.0
SHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSDKGS
 ..|||||.  ||| .. ||..| |...|| |||.|. ......||||. .||.|.. |.||| ..... .|......|| . ...|. |...|. .. .
dsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgdd

SSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSI
 | .|.... ..|| .||   ....|.....| . ... ..|||.||||. |.|.|... . ..||| ..|. |..... | .|. .||||.|..||  .
esrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl

YEVISMYL
||.. ..|
yeallell
subfamily_Ptp69D_pd Subfamily Ptp69D 8-219 4.4e-59 195.1 In-house 72-287 (307) alignment 
Range on Protein: 8-219
Range on HMM: 72-287/307.0
SQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSD
 .|.  ||||||  ||.||. ||.|| |.|.|. |||.|| . .|  ||||   .|  .. | .|| . |.. .|.  .|. |.. .. ||.|...|   
gkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskk

KGS-----SSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVT
| .      | .|.|.. |.|.   | . .|..|..|..| . ...   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |.
keesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvq

TLDQYSSIYEVISMYLK
 |.||. .|  .  | .
sleqYvflyralldyss
0045098 (Phosphotyrosine protein) phosphatases II 7-220 8.8e-59 194.5 In-house 51-274 (278) alignment 
Range on Protein: 7-220
Range on HMM: 51-274/278.0
VsqeshGYINASFTAGYreKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHS
.     .|||||.  ||  ...||..| |...|| |||.|. ......||||.. .|.|.| |.||| |.... .|......|| . .. |. |...|. 
k.....dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtn

D----KGSSSWNVMQFQVTNWPQDGVIKEP--RTVLQVIDEVIHRQQK------------IGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaEGVVDVFQ
     ..  |..| ... ..||  ||  .|  . .|...... .....             .||||.||||  |.|.|... . . ||..  ||.||...
ltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlle

VTKSVRRSKPG-AVTTLDQYSSIYEVISMYLKL
. | .|. .|| ||..|.||  .||.. ..|. 
avkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPRA_pd Subfamily PTPRA 9-218 1.7e-57 189.8 In-house 83-295 (330) alignment 
Range on Protein: 9-218
Range on HMM: 83-295/330.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVH--S
.|.  ||||||  ||.||  || || | |.|| |||.|| ..| ..||||   .|  .| |.||| .  ....|.  ..   .. .. |  ||| |.  .
veesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlp

DK--GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
|.    .|  | ||  | ||. ||  ||. .|... .| . .|. .| |.|||||  | |.| .. ..  ||. |||..||||.. |..|  .|  | |.
datrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtd

DQYSSIYEVISMYL
 ||  ||.|.  | 
eqyefiykvlleyy
subfamily_PTPRK_pd Subfamily PTPRK 7-214 5.9e-55 181.3 In-house 65-273 (314) alignment 
Range on Protein: 7-214
Range on HMM: 65-273/314.0
VSQE-SHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTIsFGEYFIKCLSSKDCNGYIERKFNVH
.  . |  ||||... .|.  .|||..| |...||.|||... |.. ..||||    | |.  |..|| |  .. .|.  .......  . .. | |.|.
idgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrve

S-DKGSS-SWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
   .| .    | ||| ..||. .| .. ...|... .| . |.. . |..|||||    |.|... ..| |.  . |||||||.. |..| .|.  | |
klargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvet

LDQYSSIYEVI
 .||  ||.||
eeqykfiydvi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 9-221 5e-54 178.4 In-house 76-287 (297) alignment 
Range on Protein: 9-221
Range on HMM: 76-287/297.0
QESHGYINASFTAGYREkrAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQeCCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSDK
. .  |.||||  |...   .|  | ||..|| |||.|..|..||.||||   .|  .  | .|| .. . .||.  .. || ....|.|.|...|  .|
dpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgk

GSSSWNVMQFQVTNWPQDGVIK--EPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQ
  .   | |.| ..||.. | .  . ...|..|.|| .  ..   ||..|||.  | | ||....   . . | |  ||.|.. | .|...|  | | .|
akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeq

YSSIYEVISMYLKLH
|. .|...  .|  .
ykfvyvavleallse
0037934 (Phosphotyrosine protein) phosphatases II 10-218 9.7e-54 177.8 In-house 30-242 (243) alignment 
Range on Protein: 10-218
Range on HMM: 30-242/243.0
ESHGYINASFTAGYreKRaFIIAQSPMENTVRD----FWKMIVDYKVSAIVMLCGTEEDGQECCYQYWResDTISFGEYFIKCLSSKDCNGYIERKFNVH
|...||||... ..  .| .|. | |...|| |    ||.|. ......||||. ..| |.| |.|||   ... .|......||.. ...|. |.. . 
egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygdftvtllseehlddytvrtllle

SDK-GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQK-------IGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaeGvVDVFQVTKSVRRSK
  . .  ...|.... ..||  ||  .|  .|. .|||.  ...        .||||.||||  |.|.|...   . |...   | ||.... | .|. .
nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqR

PG-AVTTLDQYSSIYEVISMYL
|| ||.|..||  .||.. ..|
pgkavqtpsqyrflyeallell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 8-214 5.9e-53 174.6 In-house 53-262 (283) alignment 
Range on Protein: 8-214
Range on HMM: 53-262/283.0
SQESHGYINASFTA---GYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNV
  ||. ||||.|      |.... .||||||...||.|||||. | |..|||||    || .. | ||| .  .. .||. .        | .| ... .
ksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelll

HSD-KGSSSWNVMQFQVTNWpqdgVIKEPRTVLQ---VIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGA
. .    |.  .  .|| .|    .  .. ...     .. ||  |..   ||.||||| .. |..|....| .... ..| |||||.| | .|  ...|
rvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmma

VTTLDQYSSIYEVI
| |||||  ..|..
vqtldqyklvhelv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 10-223 1.3e-51 170.3 In-house 70-282 (315) alignment 
Range on Protein: 10-223
Range on HMM: 70-282/315.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE--SDTISFGEYFIKCLSSKDCNGYIERKFnvHSD
  . |||||.  .. . .|.| .| | . .| |||.|....||..|||.   .|. .  | ||| .  .|.. ||.. .. || . . . . ||.     
PdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtr

KGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQY
|. .| .| ||| |.||. || |.  ..|..| ||    ..    ...||||  | |.|| .|.   ..| | . .||||.. | .|. .|  | | ..|
kseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeey

SSIYEVISMYLKLHST
. ||...  .|. . |
afiydavledllwrnt
subfamily_PTPRG_pd Subfamily PTPRG 9-217 6.6e-51 168.2 In-house 73-286 (563) alignment 
Range on Protein: 9-217
Range on HMM: 73-286/563.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHS--
.... ||||..  ||. ..|||..| |...|. |||.|| . .|. |||.   .|.|.. | .|| . ... .|.  ..  ...    | .|.. ..   
kkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlk

-DKGS---SSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVT
 .|..   .  .|.|.. |.||. || . .  ||. .     . .|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.
lkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvq

TLDQYSSIYEVISMY
| .||  .....   
teEqYiflhdallea
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 10-223 7.2e-51 167.8 In-house 69-281 (515) alignment 
Range on Protein: 10-223
Range on HMM: 69-281/515.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE--SDTISFGEYFIKCLSSKDCNGYIERKFNVHsd
  . |.|||.  ..   .|.| .| | . .| |||.......|..|.|.   .|. .  | .|| .  .|.. ||.. .. .| . | | | ||..|   
PhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl..

KGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQY
||. |  | ||. |.||. || |. ...|..| ||   ....   |...|||  | | ||..|.   . . |   .||||.. . .|. .|  | | .||
kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqy

SSIYEVISMYLKLHST
. ||...  .|.   |
afiygavledllwrnt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 10-215 3.5e-50 165.7 In-house 73-276 (288) alignment 
Range on Protein: 10-215
Range on HMM: 73-276/288.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDT-ISFGEYFIKCLSSKDCNGYIERKFNVHsdK
..  |||||. .|...|...| .|.|. .|| |||... ..|.| |||| .  |.|.. | .|| ..|.   .|.  .. ..||. . ...||. ..  |
agaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..k

GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYS
  .  .. |.| . ||..|| .  . .|.... |   .|.   ||..||||. | |.|.. ..  .... ..| ..||. . . .|....  | || || 
kkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYe

SIYEVIS
 ||||. 
fiyevll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 9-214 6.3e-50 164.9 In-house 74-275 (315) alignment 
Range on Protein: 9-214
Range on HMM: 74-275/315.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESdTISFGEYFIKCLSSKDCNGYIERKFNVHSdk
..   |.||.|  ||  || .| ||.|  ..|.|||... ..... |||| .. |. .. . .|| .   . .|.. .   | .  . |  | . | .  
dphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvf..

GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYS
|.   .|.|...| ||. || |   .....|  |   ...   |..|||||. | |.| .....  |.| .|| ..||... . ||. . ..| ...|| 
gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyq

SIYEVI
 ||...
fiydal
subfamily_PTPRB_pd Subfamily PTPRB 9-219 2.7e-49 162.8 In-house 76-286 (293) alignment 
Range on Protein: 9-219
Range on HMM: 76-286/293.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES-DTISFGEYFIKCLSSKDCNGYIERKFNVHSd
...  ||||..  ||. .| || .| |. .|| |||.|. . |.|.||||  . | |.. | .|| .  ... .|.  .. ..... . .. |.....  
esgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.

kGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQ
 .... .|.|.. | ||. || ....|.|. . .| ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .|
.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq

YSSIYEVISMYLK
|  |....  .|.
Yifihqcvldllr
subfamily_PTPN12_pd Subfamily PTPN12 8-219 9.9e-49 160.8 In-house 64-278 (290) alignment 
Range on Protein: 8-219
Range on HMM: 64-278/290.0
SQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES--DTISFGEYFIKCLSSKDCN-GYIERKFNV
..|  .||||.|  |  .| ..| ||.|. .|. |||.|| ...|. .||.|   | |.  | .|| |.  ... |||. ... . | .. ... | ..|
eeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkv

HSDkgSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAV
. .  . | .| ||. |.||  || . . ..|..|..| ..|.     |.|||||  | | |. ... .. |. ||| .   .|||..  ..|. .. .|
eaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalv

TTLDQYSSIYEVISMYLK
 | .||. .|. .  ...
qtkeqyelvykavaelvq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 10-218 1.1e-48 161.0 In-house 74-288 (325) alignment 
Range on Protein: 10-218
Range on HMM: 74-288/325.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLcGTEEDGQECCYQYWRES--DTISFGEYFIKCLSSKDCNGYIERKFNVHSD
 |  |||||.   ...|  |. ||.|. .|. |.|....|.. | .|.|    . |.. | .|| .   ..  ||   .|  . ..   |. |...|   
pssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl.neldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqv

KGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKI-----GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVT
|.  .  | |||.  |.. || | | |.. ... | . ....     . .|..||||. | |.||. |.  ||..   |  ||.|.. | .|. .|  | 
kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmve

TLDQYSSIYEVISMYL
| |||. ||| .  ..
tvdqyiliyealveay
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 10-219 1.4e-48 160.4 In-house 67-277 (281) alignment 
Range on Protein: 10-219
Range on HMM: 67-277/281.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESD-TISFGEYFIKCLSSKDCNGYIERKFNVhSDK
..  ||||.| .||......|..|.|. ... .||.|....|||||||.    | |.  |..|| . . ....|.. .| ..... . ||||||.. . .
kntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.ere

GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQY
.. . .| |.. |.||. || .... .|.  .|| . ..|    |.|.|||  | |.|.| ..  ......||   .|| .| ...|...   | |. ||
sgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy

SSIYEVISMYLK
. .| ..  .|.
efvykavldald
subfamily_PTPN6_pd Subfamily PTPN6 12-223 3.9e-48 159.0 In-house 81-302 (306) alignment 
Range on Protein: 12-223
Range on HMM: 81-302/306.0
HGYINASFTAG--YREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES-DTISFGEYFIKCLSSKDCNGYIERKFNV-HSD
. ||||..  .    .....| .|  .|.|| |||.|... .   |||.    | |.| |..|| .. .. ..|.. ....|.|. . || |...| . .
sdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkk

KGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAV
|.... .|.|.. ..||. || |.| .||. ...| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. ||||. . | |
kkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglv

TTLDQYSSIYEVISMYLKLHST
 | .||  .|..|..|.. ...
qteqqykfvykaikkyietkkk
subfamily_CG7180_pd Subfamily CG7180 9-218 1.8e-47 156.4 In-house 68-290 (296) alignment 
Range on Protein: 9-218
Range on HMM: 68-290/296.0
QESHgYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQeCCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHSD-
..|. ||||..  ..  |...|. . |...|| .||... | ..||.|.|. | .  .  . .|| .     .|| |.. ...|       |.| .    
eksd.YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkki

---------KGSSSWNVMQFQVTNWPQ-DGVIKEPRTVLQVIDEVIHRQQKI----GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSV
                |..||.| |.  | |     ......  |   ..|.      |||||..|| .||||||... ..||. . |. ||||.  | .
valteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktl

RRSKPGAVTTLDQYSSIYEVISMYL
|||.|. | . ..|  ||.|.. ..
rrsRpqLvenveeYkyiYdvlleav
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 8-219 2.5e-47 156.7 In-house 85-293 (319) alignment 
Range on Protein: 8-219
Range on HMM: 85-293/319.0
SQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgteedgQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHS-
 .|   |||||| .||. |  .| || |..||. |||.|| .|..|.||.|       .. | |||     |  ... .|  | .... |. |....   
GeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsed

DKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLD
 |     .. ||    ||. || . |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | 
gkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv

QYSSIYEVISM-YLK
||  ||  .   .| 
qykfiysalleehlf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 8-219 4e-47 156.1 In-house 49-257 (284) alignment 
Range on Protein: 8-219
Range on HMM: 49-257/284.0
SQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgteedgQECCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHS-
 .|   |||||| .||. |  .| .| |..||. |||.|| .|..|.||.|       .. | |||     |  ... .|  | .... |. |....   
GeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsed

DKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLD
 |     .. ||    ||. || . |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | 
gkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv

QYSSIYEVISM-YLK
||  ||  .   .| 
qykfiysalleehlf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 9-219 3.4e-46 152.6 In-house 54-269 (274) alignment 
Range on Protein: 9-219
Range on HMM: 54-269/274.0
QESHGYINASFTAGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTI----SFGEYFIKCLSSKDCNGYIERKFN
.|   |||| .  ||.| ..|.. .| |. ||| |||.||   .|. ||||   .|  .. | .|. ..  .     .|.  ||  . ...|.|  ||. 
dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklv

VHSDKGssSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAV
... .   . .|. .  |.||   . ....|.|....|| . ...     .|||||||  . | |.. ..|||. | ..|.||||....  .|  . | |
lkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmv

TTLDQYSSIYEVISMYLK
 | .||  |......|||
qtseqyelihralclylk
subfamily_PTPN9_pd Subfamily PTPN9 9-217 6.9e-46 151.6 In-house 67-289 (297) alignment 
Range on Protein: 9-217
Range on HMM: 67-289/297.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ESDTISFGEYFIKCLSSKDCNGYIERKFNVHS
.|   ||||.|. ||..|.||| .| |...||.|||.|. . .|  |||   ..| |.  | |||   | ....||.. .. .. .  . | .|..... 
deasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleikn

DKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQ------------KIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVR
 | . | .|. ||.. ||  || ..  ..|.|...| ..|             .. | |.|||||  . |.| .... |.|.. . .|.|||... | .|
vkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllr

RSKPGAVTTLDQYSSIYEVISMY
  .  .. | .||   |  .  |
tqrafsiqtpeqyefcylavley
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 10-220 4.5e-45 148.7 In-house 46-266 (270) alignment 
Range on Protein: 10-220
Range on HMM: 46-266/270.0
ESHGYINASFTAGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES--DTISFGEYFIKCLSSK--DCNGYIERKFNV
.   |||| . .|. . |...| |..|...|...||.||.. ||.||||. | ||.|.. | .|| ..  ..... . .|| |...    .||| .. ..
sataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrl

HsDKGSsSWNVMQFQVTNWPQDGVIKEPR------TVLQVIDEV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSK
. .||. . ... |. ..||..|| .|.        .|... .|  .....  ..|..||||. | |.|.   . ||..  . .. ||| .. . .|. .
e.ekge.errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdR

PGAVTTLDQYSSIYEVISMYLKL
.  | . .||  .|.....| . 
malvqhpeqyeflykavveyaer
subfamily_PTPN3_pd Subfamily PTPN3 10-214 4.8e-43 142.1 In-house 63-271 (280) alignment 
Range on Protein: 10-214
Range on HMM: 63-271/280.0
ESHGYINASFTA----GYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE-SDTISFGEYFIKCLSSKDCNGYIERKFNV
..  ||||..      .      .|..| |...|. |||.|. . |.| ||||  . |.|.  |.||| | .|....||. .|| ...  . |. |.. .
setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvl

HSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
.  . . . ...|.| ..||. || ...  .|.....| .....    |||||||  . |.||.  . .||    |.  | . .. . .|  .   | | 
kdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta

DQYSSIYEVI
.||  . | |
sqykfvCeai
subfamily_PTPN23_pd Subfamily PTPN23 10-216 2.2e-42 139.9 In-house 65-278 (288) alignment 
Range on Protein: 10-216
Range on HMM: 65-278/288.0
ESHGYINASFTAGYREK-RAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ESDTISFGEYFIKCLSSKDCNGYIERKFNVHS
.   ||||||  .       ||..|.|...|. |||.|... |.| ||||   || |.. . .||   . .| .||.. . . | .. . ..||..... 
skDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlklet

DKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIH---RQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVT
 . .   .|.  |.|.||. || . | |.||..||| .    .|.    |.|||||  | |.||.. |  |...  | .|..|. || . .|. .   | 
ldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvq

TLDQYSSIYEVISM
. .|.   ||..  
ekeqlkfsyeavle
subfamily_PTPN14_pd Subfamily PTPN14 9-219 3.1e-40 133.0 In-house 73-297 (300) alignment 
Range on Protein: 9-219
Range on HMM: 73-297/300.0
QESHGYINASFTA--GYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES----DTISFGEYFIKCLSSKDCNGYIERKF
..|.||||||        ..| .|.||.|.|.||.|||.|. . .|. ||||  .||||.| ...|. ..    .|. ||.. .    |.| . .| ...
enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittgl

NVHSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVI----HRQQKI----GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVR
...    .   .|. .| |.||..|| ..... |. ..||     . ....       ||.||||. | |.||   . . ..  . . ..|. .| . .|
klkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLr

RSKPGAVTTLDQYSSIYEVISMYLK
. .   | || ||  .|.|.  |||
eqrmllvqtlaqYkfvYkvlikylk
0051429 (Phosphotyrosine protein) phosphatases II 12-219 5.2e-40 133.1 In-house 4-226 (272) alignment 
Range on Protein: 12-219
Range on HMM: 4-226/272.0
HGYINASFTAGYRE---KRAFIIAQSPMENTVRDFWKMiVDYKVSAIVMLCGTEEDGQECCYQYWR------------ESDTISFGEYFIKCLSSKDCNG
 |||||..  ||     ..... .. |...|..|||..  ......||.|...|| |.. |..||             .  ||..| .....|| . .. 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YIERKFNVHSD-KGSSSWNVMQFQVTNWPQDGVIKEPrtVLQVIDEVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVD--------VF
|| |.. ..   . . .  ||... |.|| .|| .|.  .|...... .      ||||.||||  ..|.|... . . |..  .| .||        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
.. . .|.  |||| | .||  .||..  .|.
eaveelraqrpgavqteeqylflyeallellr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 4-222 7.7e-40 131.5 In-house 55-281 (287) alignment 
Range on Protein: 4-222
Range on HMM: 55-281/287.0
FLVVSQESHG--YINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESD-TISFGEYFIKCLSSKD--CNgYI
 |.. .  .|  |||| . |.|... ||| ||.|.  ||||||..... ........    |...  ||.|| | .  .  | | .  |. .    . | 
vllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePe.yg

ERKFNVHSDKGSSSWNVMQFQVTNWPQDGVIKE----PRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVR
 | . .   ..  .  | |... .||....        | ||.| . .  ...  . ||.|||..  . |||.. .. . ... .  | ||| .|   .|
vralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlr

RSKPGAVTTLDQYSSIYEVISMYLKLHS
  . . | .  |.  .|| .  | |   
eyraalvqavvqlrllyealvtyyktnp
subfamily_PTPN13_pd Subfamily PTPN13 8-219 1.4e-38 127.8 In-house 56-270 (273) alignment 
Range on Protein: 8-219
Range on HMM: 56-270/273.0
SQESHGYINASFTAGY--REKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESD--TISFGE-YFIKCLSSKDCNGYIERKF
 ... ||||||.       ..  .|..| |. .||.|||.|. . |.. |.|.    |.|.  | .|| ||   ..   . . .. |  .. .|.  |..
lgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvral

NVHSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVT
.|.  . . | .|.... ..||  || ...  .||.. || . |.    ||.|||||  . |||.. .. ..|.  . .  .|| .. ...|. . | | 
avkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvq

TLDQYSSIYEVISMYLK
| |||  .|..|   ||
tkdqyifvykailevlk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 11-214 9.8e-37 121.4 In-house 28-235 (237) alignment 
Range on Protein: 11-214
Range on HMM: 28-235/237.0
SHGYINASFTAGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDT-ISFGEYFIKCLSSKDCNGYIERKFNVHSDK
.  ||||..  |.    . .| || |.|..  |||.|. . | | |||| |  |  .. |..|| ..|   ..| . .     ..   |  | . .    
gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrl

GSSSW-NVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQ
       . |.| | ||. || ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  .|.   .|  . | ||
tlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdq

YSSIYEVI
|  |...|
yvfihqti
subfamily_PTPN1_pd Subfamily PTPN1 7-213 1.7e-36 120.4 In-house 51-266 (290) alignment 
Range on Protein: 7-213
Range on HMM: 51-266/290.0
VSQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES---DTISFG--EYFIKCLSSKDCNGYIERK
. ...  |||||.    . || .|..| |. |||  ||.|. . |  |.|||    | .|  |.||| .    ... .   .. .| .| .. . |. |.
leradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrl

FNVHSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQ-KIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSK
....  |   . ....|  | ||  || . | . |. . .| .    .   ||.|.|||  . ||| .| |   | . ....    ||. .|   .|. .
lelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyr

PGAVTTLDQYSSIYEV
 | . | ||    |  
lGliqtadqlrfsyla
0036282 (Phosphotyrosine protein) phosphatases II 13-212 6.4e-36 119.0 In-house 3-164 (174) alignment 
Range on Protein: 13-212
Range on HMM: 3-164/174.0
GYINASFTAGYREKRAFIIAQSPMEntvrdFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWREsdtisfgeyfikclsskdcngyierkfnvhsDKGSSS
 |||||.  ...  . .|. | |..     ||.|. .......|||.  .|.| . |..|| |                               .. . .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredle

WNVMQFQVTNWPQDGVIKEPRtVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKaEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
 ...|.. ..|| .||   .  .|.....| . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 11-216 1.7e-35 117.3 In-house 76-277 (439) alignment 
Range on Protein: 11-216
Range on HMM: 76-277/439.0
SHgYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEdgqecCYQYWRESDTISFGEYFIKCLSSKDCNGYIERKFNVHS--DK
|| |||| .  || ... .| .| | ..|. |||..... |.. ||||.   |      |.||  .. . .|.  ...    .   |. | |.|    |.
sh.yinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve.....sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdt

GSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYS
.     |.||. . ||.  |  .   ||. .  .   ..|   ||||||||  | |.|   .. ||||| |.|  ||.  . | .|. .   | .| || 
tekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyv

SIYEVISM
 ||. .  
fiynavle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 5-217 1e-34 114.8 In-house 50-258 (267) alignment 
Range on Protein: 5-217
Range on HMM: 50-258/267.0
LVVSQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYwRESDTISFGEYFIKCLSSKDCNGYIERKFNV
...... . |||||.  ||. |.|||. | |..||. ||...| |.||. ||.|  . .|     .   .  ..  . .  ..    |. | |    ...
vilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPP.kmgqakkyqdltvehslekeendyqiitlel

HSdKGSSSWNVMQFQVTNWPQDGVIKEprtVLQV-IDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.  |  |. ||  .   .|  .   |     |.  .  . . | . |. |.||.||| | ||| .  .   ||. | |||.|.|.  . .|  ..| | |
kf.knesahnvtlyyykkwnintnnkp...ylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdt

LDQYSSIYEVISMY
...|  |.|... |
keryiyihellaey
0041856 (Phosphotyrosine protein) phosphatases II 13-220 1.2e-34 114.9 In-house 20-173 (182) alignment 
Range on Protein: 13-220
Range on HMM: 20-173/182.0
GYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgteedgqecCYQYWResdtisfgeY-Fikclsskdcngyierkfnvhsdkgss
 ||||.. .|..  . ||..| |. .|| ||..|. ......||.|.         ...||            .                          
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........ell..........................

SWNVMQFQVTNWPQDGVIKePRTVLQVIDEVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGvVDVFQVTKSVRRSKPGAVTTLDQYSSIY
  ...|.. ..|| .||   ....|. |.||..      ||||.||||  |.|.|...   . ...    | |..... | ||. .||.|.|..||  ..
erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflq

EVISMYLKL
 .. ..|.|
lallellll
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 10-216 1.1e-33 111.2 In-house 71-234 (392) alignment 
Range on Protein: 10-216
Range on HMM: 71-234/392.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGqeccyqywresdtisfgeyfikclsskdcngyierkfnvhsdKG
  . |.|||.  ..  ..|.| .|.|   .. |||.|. . .|..|.|.   .|                                            ||
pdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........................................kg

SSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSS
 .   | ||..|.||...| |   ..|..| ||     .    |...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | .||. 
ddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyaf

IYEVISM
||  .  
iygavle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 13-216 1.4e-33 110.8 In-house 82-281 (290) alignment 
Range on Protein: 13-216
Range on HMM: 82-281/290.0
GYINASFTAGYreKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE--SDTISFGEYFIKCLSSKDCNGYI-ERKFNVHSDKG
 |. | .  |   |  ||..| ....|| |.|.|... ||.||||||   |||.  | ||. |   ....|||. . |  ..| .  |  . . |   . 
dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkds

SSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIALeQCKAEG-VVDVFQVTKSVRRSKPGAVTTLDQYS
  .  .  ...  ||.  | .   ..|...  .  |.     ||||||||  . |.| . .. ..| |.  .|  .|. .. ...|.|. ..|    || 
Gkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqyl

SIYEVISM
 . |..  
alveilld
subfamily_PTPRN_pd Subfamily PTPRN 8-214 4.7e-33 109.2 In-house 80-288 (297) alignment 
Range on Protein: 8-214
Range on HMM: 80-288/297.0
SQESHGYINASFTAGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFGEYFIKCLSSK-DCNGYIERKFNVH
|.|.. |||||.       . |.| .|.|. .|| |||.|. .  |  ||.|.  ||.| . |..|| .  .  .. | .. .| .  |. |. | | . 
saeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylk

SDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIhRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTL
  . | .  | ||    ||. ||  .....|.    |  .  .    |.|||||| . |.|||. . . |..  |    .|.    . .|  .|| | | 
nlqtsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktk

DQYSSIYEVI
||.  .. ..
dqfefaltav
0046846 (Phosphotyrosine protein) phosphatases II 9-218 6e-32 106.2 In-house 9-173 (176) alignment 
Range on Protein: 9-218
Range on HMM: 9-173/176.0
QESHGYINASFTAGYRekraFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISFgeyfikclsskdcngyierkfnvhsdk
...  ||||.. .|.|    .|. | |...|. ||..|. .....|.|.|.   | |.  |..|| |  . ..                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

gssswnvmQFQVTNWPQDGVIKEpRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSialeQCKAEGVVDVFQVTKSVRRSKP-GAVTTLDQY
        |.....||  ||    . .|......  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| .||
........qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQy

SSIYEVISMYL
  .||.. ..|
rflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 10-213 6e-32 106.1 In-house 3-156 (172) alignment 
Range on Protein: 10-213
Range on HMM: 3-156/172.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTeedgqeccyqywresdtisfgeyfikclsskdcngyierkfnvHSDKG
|.. |||||.  .|.  . ||. | |. ||. |||.|. ......||.|..                                              |. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

SSSWNVMQFQVTNWPQDGVIkEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaEGVvDVFQVTKSVRRSKPGAVTTLDQYSS
  . ...|.. ..||  ||   .. .|.... . .....  ||||.||||  |.|.|. .   . |     .|. ..... . ||. .||||.. .||  
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrf

IYEV
.|. 
lyyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 21-215 6.8e-31 102.0 In-house 230-435 (440) alignment 
Range on Protein: 21-215
Range on HMM: 230-435/440.0
AGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEdgqECCYQYWR-ESDTISFGEYFIKCLSSKDCNGYIERKFNVHSDKgsSSWNVMQFQ
 ||  | ||| .| |.. || |||... ||..|.|.||   ..     |  ||  .. ...|| . .    |.. |    | ....  .     .. ||.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyke..evheirqfe

VTNWP----QDGVIKEPR---TVLQVIDEV----IHR---QQKIGG-GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
|  ||     |||  . .   .|||..| .    | |   | . |   |..|||   .  |||.|.|   ||| . .| .||||  . .| |.|  | ||
vqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptl

DQYSSIYEVIS
 .|   | ...
tdyllcykllt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 10-211 7.2e-31 102.2 In-house 32-233 (239) alignment 
Range on Protein: 10-211
Range on HMM: 32-233/239.0
ESH-GYINASFTAGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESdTISFGEYFIKCLSSKDCNGYIERKFNVHSD
. |  |||||.   |    .|.| .|  .| .  |||.|. . .   |||| |  |  .. |.||| .| |  . .  .    ..    || | | .   
dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskycnlrvtlrktevfadyiirtfvmsqv

KGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIdEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQY
  .    | |...| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  |..|  .|  | | .||
gqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy

SSIY
  |.
vfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 10-211 7.3e-31 102.1 In-house 33-234 (239) alignment 
Range on Protein: 10-211
Range on HMM: 33-234/239.0
ESH-GYINASFTAGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESdTISFGEYFIKCLSSKDCNGYIERKFNVHSD
. |  |||||.   |    .|.| .|  .| .  |||.|. . .   |||| |  |  .. |.||| .| |  . .  .    ..    || | | .   
dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskycnlrvtlrktevfadyiirtfvmsqv

KGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIdEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQY
  .    | |...| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  |..|  .|  | | .||
gqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy

SSIY
  |.
vfih
0049260 (Phosphotyrosine protein) phosphatases II 21-212 4.2e-30 99.8 In-house 3-144 (152) alignment 
Range on Protein: 21-212
Range on HMM: 3-144/152.0
AGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWresdtisfgeyfikclsskdcngyierkfnvhsdkgssswnvmQFQV
 ||. ...||..| |..||. |||.|. ......||||.  .|.| ..|.||.                                           |.. 
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylh

TNWPQDGVIKEPRTVLQVIDEVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaeGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
..|| .|| . .  .|.... . .. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .||
lpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 10-225 4.8e-27 89.8 In-house 65-286 (307) alignment 
Range on Protein: 10-225
Range on HMM: 65-286/307.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ESDTISFGEY----FIKCLSSKDCNG---YIeR
 .  || | .     . . || || |.|||. .|| |... || ...||| . | ..  | |||   | ..  |||      .. | .|       .|  
lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli.n

KFNVHSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIALEQ-CKAEGVVDVFQVTKSVRRSKPG
  ... | .. |  . ..| .|||. || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. 
vttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhy

AVTTLDQYSSIYEVIS-MYLKLH-STYA
|. |  ||  .. |.   .|.|.  ||.
aiqteaqylylhrvlleyflelyketye
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 11-219 5.3e-27 89.7 In-house 45-260 (290) alignment 
Range on Protein: 11-219
Range on HMM: 45-260/290.0
SHGYINASFTAgYREKRAFIIAQSPMEN-------TVRDFWKMIVDYKVSAIVMLCGTEEDGQE----CCYQYWRESDT--ISFGEYFIKCLSSKDCNGY
. .|| |..   . .  ..|. ||| |.       |. .|| |. . ||  .||||  ||  ..     | .| .||    . |.   .|| |    .. 
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

IERKFNVHSDKGSsSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIALEQCK-AEGVVDVFQVTKSVRRS
..|.  |. |..   . |   .. .| .  | ....|.|..|. |  ..      ||.||| | .||| .  .. ..       .| | . .| |..|. 
etRelvvkfddee.eftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkq

KPGAVTTLDQYSSIYEVISMYLK
.  |.|.  ... .  .| ....
ralaitsalelafvdagivllai
0049772 (Phosphotyrosine protein) phosphatases II 10-220 1.6e-26 89.2 In-house 70-282 (314) alignment 
Range on Protein: 10-220
Range on HMM: 70-282/314.0
ESHGYINASFTAGYrekRAFIIAQSPMENTVRDF----------WKMIV--DYKVSAIVM---------------------LCGTEEDGqeccyQYWRES
....|||||.  |.   ..||..| |.|.|| ||          |.|..  |..|  |||                     |..  . |      .. ..
sgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaa

DTISFGeyfikclsskdcngyierkfNVHSDKGSSSWNVMQFQVTNWPQDGVIkEPRTVLQVIDEVIHRqqkIGGGPVVVHCSDTVSRSGVYCSVSIALE
|   .                     ... |.   . .....  ...| ...   .. ...... .        ||||.|||.. ..|.|... . . . 
dlellk....................eelydpelferlgikylripvpDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmk

QCkaeGVvDVFQVTKSVRRSKP-----GAVTTLDQYSSIYEVISMYLKL
..   || .. .. . ||.  |     |.. .|.||  |.|.. .||| 
ll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 8-221 1.7e-26 87.9 In-house 63-274 (288) alignment 
Range on Protein: 8-221
Range on HMM: 63-274/288.0
SQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYW--RESDTISFGEYfikCLSSKDCNGYIERKFNV-
| ... ||.|   .  . || .| ||.|.. |.  .|||...  |  |||||   | |.|   .|.  .  ... .| .   |   |. .  |..  .| 
sddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl...ctvvkkkradidklvkvs

--HSDKGSSSWN-VMQFQVTNWPQDGVIKEPRTVLQVIDEViHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAV
  .  |       | .  . .|..||| ..  . |.... . .  ||    |.|||.|  | |.|    . ||||. . .  . . .. .. | ..  |.
llriskegeekvivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkai

TTLDQYSSIYEVISMYLKLH
.|  ||  .. ..  .| |.
qtemqylyvhrcvleelllk
PTPc_DSPc_SM00012 115-214 1.9e-26 87.7 In-house 2-103 (105) alignment 
Range on Protein: 115-214
Range on HMM: 2-103/105.0
VMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
|.....|.||. || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..|.|.|...| . ||.||. |..|...||.|.|..||. .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al
0051082 (Phosphotyrosine protein) phosphatases II 12-213 3.1e-26 87.2 In-house 3-148 (151) alignment 
Range on Protein: 12-213
Range on HMM: 3-148/151.0
HGYINASFTAGYrekraFIIAQSPMEntvrDFWKMIVDYKVSAIVMLCGTEEDGqeCCYQYWRESDtisfgeyfikclsskdcngyierkfnvhsdkgss
 .|||.|.  |.     ... . |..    ||.... ......||.|...|| |   |..|..| .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaegvVDVFQVTKSVRRSKPGAVTTLDQYSSIY
  .|.......||  |.   . .||........     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  ..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

EV
 .
fa
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 11-219 3.7e-26 86.6 In-house 72-288 (305) alignment 
Range on Protein: 11-219
Range on HMM: 72-288/305.0
SHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYW--RESDTISFGEY----FIKCLSSKDCNGYIERKFNV
 | || | . .   . . || .|.|.|.|  ||| | .. || || |||   | | . |..|.  .. |...| |      .|. ||.  .   . | .|
pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakv

------HSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVihrqqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVV-DVFQVTKSVRRSK
          |...  | ..   .||. ||     ..|... .      .   ||.|||||  . |.|    .   |.|  |  .. |  .. . .|  .
tetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka.....rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqr

PGAVTTLDQYSSIYEVISMYLK
  .. | .||  ...||  |..
nnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 17-207 1.7e-25 84.4 In-house 80-270 (301) alignment 
Range on Protein: 17-207
Range on HMM: 80-270/301.0
ASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYW--RESDTISFGEYFIKCLSSKDC--NGYIERKFNVHSDKG-SS
| .     . . ||..|.|..||  ||| |.| |.|  ||||. . |. .| | .|   . |...  | . ||  ...    .  ..|...|.   |  .
anwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfa

SWNVMQFQVTNWPQDGVIKEPRTVLQVIdEVIHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQY
.  |. .| ..|.. || |    . ... |.. . .|    |.|||||. . ||  . .  .   . .|.  ... .  | .|  .  .| |  | 
trtvthyqysewtdrgvPkshaelfdlm.elvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 4-214 1.5e-23 77.9 In-house 58-265 (281) alignment 
Range on Protein: 4-214
Range on HMM: 58-265/281.0
FLVVSQESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESD--TISFGEYFIKCLSSKDCNGYIERK
. .  ..|  || | .      || .|..| | ..|  |||.|| . . .||||||   |  .| | .|.       . | .. ..   |   .  .  .
vkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr

FNVhSDKGSSsWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRqqkigGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRS-KPG
.|. | .| .   . ..   .||.  | .    .|... ..  |       | |.|||  | |||   .| |||.  ..   . |. |.   .| . .  
lnl.syeget.rlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraa

AVTTLDQYSSIYEVI
.| ||.||  |..|.
svqtlqqymliwkvl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 13-218 5.6e-23 76.0 In-house 81-289 (305) alignment 
Range on Protein: 13-218
Range on HMM: 81-289/305.0
GYINASFTAG-YREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR----ESDTISFGEYFIKCLSSKDCNGYIERKFNV--H
 || | .       .. || || |...|. .|| |... ||  ||||| | | |.  | |||     |  ..  |    .   ||  .   | .  .   
dyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnl

SDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIALEQCKA-EGVVDVFQVTKSVRRSKPGAVTTL
.  |. .  | ..| |.||. ||     | |...  .  |  |.   |.|||||  . |.|   ..   ||.      .  . .. |..|  .  .. . 
tysgdqkmsvrhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqnd

DQYSSIYEVISMYL
 ||  |. |.  |.
vqylfihrvmlnyf
0044763 (Phosphotyrosine protein) phosphatases II 13-220 2e-22 75.1 In-house 19-173 (178) alignment 
Range on Protein: 13-220
Range on HMM: 19-173/178.0
GYINASFTAGYrekraFIIAQSPMentvRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTisfgeyfikclsskdcngyierkfnvhsdkgsss
 |||||.  ..     ..... |.     |..... ......||.|... | |.. |..|| |.                                    
dyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..................................

wnvMQFQVTNWPQDGVIKEPRTVLQVIdEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGVvDVFQVTKSVRRSKPgAVTTLDQYSSIYE
   .|.. ...| .||   .. .|... | |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .|.  .||
...iqylhipipDhgvpdllehflefv.efieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLye

VISMYLKL
. ...|| 
felrllke
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 5-218 1.5e-21 71.6 In-house 52-270 (285) alignment 
Range on Protein: 5-218
Range on HMM: 52-270/285.0
LVVSQESHGYINASFTA-GYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE--SDTISFGEYFIKCLSSKD--CNGYIE
.|. .  . || ||.     ... ..| .| |. .|. |||.|| . |.. ..|||   | | | |  |. |   . . ||.| |     |.    | | 
vvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtil

RKFNVHSDKGSS--SWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSK
  . |   . .|     . . ||  ||..   .. | ....   | . . |    |..||||  | |.  .  .  |  .   .  ...... . .|  .
naltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramr

PGAVTTLDQYSSIYEVISMYL
  || .  |.  .| |.  |.
fqavqshmqflflyvvlmeyf
subfamily_egg_pd Subfamily egg 12-219 2.5e-21 70.6 In-house 68-271 (307) alignment 
Range on Protein: 12-219
Range on HMM: 68-271/307.0
HGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDgQECCYqYWR--ESDTISF--GEYFIKCLSSKDCNGYIERKFNVHSD
  .| |    |      ||.||.|. ||| |||.|.   .|  ||||  . |  ..| | ||   |||.. .  | . |..|  ..    . |  ...  
ddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.ercey.ywpkaesdslvtvpGslrienlkvdskadplfrvtklklv

KGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIdevihrqqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVV--DVFQVTKSVRRSKPGAVTTLD
 |      ..    .. . . .  |  ||. .        .    ||||.. . ||....  .. ||| .     ..   | .  . .|. .. .| .  
Ggddeerflehwqgdvnnssdvysplrvlrkl........rnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvl

QYSSIYEVISMYLK
.|  .| .. ....
lylfvyrlvlfffr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 12-216 3.1e-20 67.0 In-house 79-288 (310) alignment 
Range on Protein: 12-216
Range on HMM: 79-288/310.0
HGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES-DTISFGEYFIKCLSS--K---DCNGYIE-RKFNV
. || | .      . .|| .| |.. |. |||.|| . .  .|..|| . |.|.  |  ||     | ..|   .  ||   .    ||  .     ||
edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnv

HSDKGSSSWNVM---QFQVTNWPQDGVIKEP-RTVLQvideVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGA
  |.  .  . .     .  |||. ||  |   || |     .  |  .  ||.|||||  . | .| ... ..... .    ||. .|   ...|.   
pvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq....rllaq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraic

VTTLDQYSSIYEVISM
. |  ||  |  |  .
iqtelqyliidrvrii
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 25-213 2e-19 64.5 In-house 3-199 (199) alignment 
Range on Protein: 25-213
Range on HMM: 3-199/199.0
EKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDgQECCYQ-YW--RESDTISFGEYFI--KCLSSKDCNGYIERKFNVHSDKGSSSWNVMQFQ
 .| .| .| |. .|. |||.|. .     |||.   . . .|. |  ||   || |  .|   .  |....|         .   .    |. .. ..|
gqrryiatqhplretmadfwqmvwetgsghivmvnddqkn.keadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

VTNWPQDGVIKEPRTVLQVI--DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEV
 | | .    .    |  |.   || .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 4-223 2.4e-19 63.9 In-house 67-290 (302) alignment 
Range on Protein: 4-223
Range on HMM: 67-290/302.0
FLVVSQESHGYINASFTAGYREKRAFIIAQSPMENTV---RDFWKMIVDYKVSAIVMLCGTEEDGQeCCYQYWR-E-SDTISFGEYFIKCLSSKDCNGYI
 . ...|   |.||| .     .|  |.|| |  ...    .||.|. . |.  .|.| |.||  .    ...  .  |   .|. |.     .  ..  
lvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek

-ERKFNVHSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSK
 .    |  .  | |  ..   .|||.|. | ..  .. . . .| . ..  .  ..|.     . | |.  .. .|.|. ...  . . .. ||.|  .
tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqR

PGAVTTLDQYSSIYEVISMYLKLHST
| || .|.|| |.| .. .|.| . |
pravdslkQyvslyialllyikkkvt
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 26-213 2.5e-19 64.3 In-house 3-198 (198) alignment 
Range on Protein: 26-213
Range on HMM: 3-198/198.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDgQECCYQ-YW--RESDTISFGEYFI--KCLSSKDCNGYIERKFNVHSDKGSSSWNVMQFQV
.| .| .| |. .|. |||.|. .     |||.   . . .|. |  ||   || |  .|   .  |....|         .   .    |. .. ..| 
qrryiatqhplretladfwqmvwetgsghivmvnddqkn.keadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWPQDGVIKEPRTVLQVI--DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEV
| | .    .    |  |.   || .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 33-208 7.3e-19 62.3 In-house 97-278 (302) alignment 
Range on Protein: 33-208
Range on HMM: 97-278/302.0
QSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE--SDTISFGEYFIKCLSSK-DCNGYIERK-F-----NVHSDKG--SSSWNVMQFQVT
  |  .|.  .| .| .|.|. .| ||.  ||... | .|. .   ... ||.| .| .| | | . . ..| |     ... .|        |  .. .
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

NWPQDGVIKEPRTVLQVIDEVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYS
 ||. |  ||. | |...      ...     |.||||  | |.|   ..   .. |. . | |. .. . ||. . ||| . .|  
awpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 10-220 9.1e-19 62.3 In-house 65-278 (312) alignment 
Range on Protein: 10-220
Range on HMM: 65-278/312.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWreSDTISF---------GEYFIKC-LSSKDCNGYIE
.   || | |         |...|.|.|||.  ||.. .    ..|..|||  ||| | | .|   || ..|          ||  .  .  |  .    
denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi..sdivgfvdledhrvyteycteieiggkskdkith

RKFNVHSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEViHRQQKigggPVVVHCSDTVSRSGVYC---SVSIALEQCKAEGVVDVFQVtksVRRS
| ..|         .. ..| . ||. |.     | |...  | ....|    ||. |||  | |.|  .   |.  || . . . | |.| .   .|. 
rvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkd

KPGAVTTLDQYSSIYEVISMYLKL
.  .| .. ||     ..  .|  
rarsvrvfpqyvyalrcvleflys
subfamily_ptpA1_pd Subfamily ptpA1 8-176 8.7e-18 59.2 In-house 71-254 (418) alignment 
Range on Protein: 8-176
Range on HMM: 71-254/418.0
SQESHGYINASFTAGYREKrAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESD-----------TISFGEYFIKCLSS-KDCN
 .|   |||| .  |   |  || .| |. ||. |||.|. . ..  ||||    |. .  | .|| |                || | .. .   .| .
dkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe

GYI-ERkfNVHSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIALE
  |  |  |..      . .. |.|   ||.  .    . . |..  .  ||..|        |..||||  | |.| .|.  | ..
reiitr..nirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 11-130 1.2e-17 58.8 In-house 58-181 (297) alignment 
Range on Protein: 11-130
Range on HMM: 58-181/297.0
SHGYINASFTAGYREKR--AFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDT--ISFGEYFIKCLSSKD--CNGYIERKFNV
 . |||| . .   |.    .|.|| |...|| |||.....  | .|||..  .|||.. |. || ...      |.. .. |||     .  |  ....
erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelql

HSDkgSSSWNVMQFQVTNWPQDGVIK
     | |  |   |  .||. ||  
iyr..sesrvvrhvqflswpdhGvps
subfamily_CG42327_pd Subfamily CG42327 8-142 5.4e-17 56.4 In-house 52-190 (319) alignment 
Range on Protein: 8-142
Range on HMM: 52-190/319.0
SQESHGYINASFTAGYREKRA-FIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDT----ISFGEYFIKCLSSKDCNGYIERKF
....  |..||.  ||.. .. .| || ..|..  |||... . .   || |.   | | . | .|.  ..|     ..|.. .     .  . |.   .
dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistl

NVHSDKGSSSWNVMQFQVtNWPQDGVIKEPRTVLQVIDEV
 ..  ... | ..  .   .|.. .|  |..... .. ||
llkrvdkeesrelthywy.kwleaevPaeeaaliamllev
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 12-129 6.1e-17 56.0 In-house 122-236 (244) alignment 
Range on Protein: 12-129
Range on HMM: 122-236/244.0
HGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGqeccyQYWRESDTISFGEYFI-KCLSSKDCNGYIE-RKFNVHSDKG
  ||||||         .|..| |. .|  |||||... .|  .|.|   ||.      .|| .|. . . |  |   |. .|    |   .... ||  
ntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdseplewyeeditvtltdrdefknikasnleiesdmn

SSSWNVMQFQVTNWPQDGVI
 |   .  ||..||| ||  
eshqaltmfqisnwpsdgtt
0048076 (Phosphotyrosine protein) phosphatases II 90-217 9e-17 56.6 In-house 22-142 (145) alignment 
Range on Protein: 90-217
Range on HMM: 22-142/145.0
SSKDCNGYIERKFNVHSDKGSSSWNVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiALEQCKAEGvVDVFQV
    ..  | . .|. |..   . ...|.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.|...    |.  .. .| |.....
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleea

TKSVRRSKPGAVTTLDQYSSIYEVISMY
 . ||.  ||||.. .|.  .||.. ..
lelvrsqrpgavpnpgqlrflyefelel
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 11-129 2.6e-16 54.1 In-house 12-127 (130) alignment 
Range on Protein: 11-129
Range on HMM: 12-127/130.0
SHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGqeccyQYWRESDTIS-FGEYFIKCLSSKDCNGYIER-KFNVHSDK
 . ||||||       . .. .| |. .|  |||||...  |  .|.|   ||.      .|| .|. .  . |  |  |. .|   .|.  .....|| 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdrdefknikasnleiesdl

GSSSWNVMQFQVTNWPQDGVI
  |   .  ||..||| ||  
neshqaltmfqisnwpsdgtt
0048179 (Phosphotyrosine protein) phosphatases II 46-212 3.4e-15 51.5 In-house 24-139 (144) alignment 
Range on Protein: 46-212
Range on HMM: 24-139/144.0
MIVDYKVSAIVMLCGTEEDGQECCYqywresdtisfgeyfikclsskdcngyierkfnvhsdkgssswnVMQFQVTNWPQDGVIKEPRTVLQVIDEVIHR
.. ........ |. . |   . ..                                            ..|.. ..||  ||   .  .|.... . . 
llkklgittvinlteeyepeflere............................................giqylhlpwpDhgvpdllellleflefieea

QQkiGGGPVVVHCSDTVSRSGVYCSVSIALeqckAEGvVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
..   ||||.||||  |.|.|...   . .     .| ...... . ||.  ||||.. .|.  ..|
le..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_CG42327_pd Subfamily CG42327 150-219 4.5e-15 50.1 In-house 246-316 (319) alignment 
Range on Protein: 150-219
Range on HMM: 246-316/319.0
GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
  ||.|||||| | |.|.  .  ||... .     ||. |.  |||| .  || | .||  || |.|.| |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 12-216 2.1e-14 47.8 In-house 69-277 (303) alignment 
Range on Protein: 12-216
Range on HMM: 69-277/303.0
HGYINASFTAGYREKRAfIIAQSPMENTVRDFWKMIVDYKVSAIVML-CGTEEDGQECCYQYWRESDTISFGEYFIKCLSSKDCN---GYIERKFNVHSD
  || ||.     .|.| |..| |.  |  |||.||.. ||  ...|   .| |     . . |. | . | | .|.    |  .   |.  .   |   
ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsng

KGSSSwnVMQFQVTNWPQDGVIKE--PRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTL
.  |   .   .  .||.. .  .  |. | |. .     ..   . | |      . |.| ..    |    ..|   .|. .. . ||  .  ||  |
dyksf..lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnl

DQYSSIYEVISM
 |.| .| ... 
sqfsvvytllae
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 11-77 6.2e-14 46.5 In-house 82-154 (350) alignment 
Range on Protein: 11-77
Range on HMM: 82-154/350.0
SHGYINASFTA----GYREKRAF--IIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESD
.  ||||..      . . .  |  | .|.|. .|| ||.|.|.  ||  |..|    | . | ||.||.| .
tnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs
subfamily_eak_pd Subfamily eak 10-125 2.1e-13 44.4 In-house 76-191 (332) alignment 
Range on Protein: 10-125
Range on HMM: 76-191/332.0
ESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES--DTISFGEYFIKCLSSKDCNGYIERKFNVHsd
.  |||||| .      | .|..  . |. |  ||.|... |  |||.|    | . |   .|. .   . ..|| . ... .    | .  |.. ..  
nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllels..

KGSSSWNVMQFQVTNWPQ
||  . .|. ..|  | .
kGnethrvlhykvfGwte
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 39-203 8.1e-13 43.0 In-house 40-206 (255) alignment 
Range on Protein: 39-203
Range on HMM: 40-206/255.0
TVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR-ESD-TISFGEYFIKCLSskDCNGYIERKFNVHSDKG--SSSWNVMQFQVTNWPQDGVIKEPRT
||  |...||  | . .||||  .|.|.| | .|.  | |    . .  . .      .  . |  .. |  |      .|  .. . |..    ...| 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

VLQVIDEVihRQQKigggPVVVHCSDTVSRSGVYCSVSIALE-------QCKaEGVVDVFQVTKSVRRSKPGAVTT
.|...  |  |. |    .||||||  . ||  .  . ..         . .  . .|  .. . .| ....|. |
ilnilkvv..rdsk....svvvhCstGiGrsaafvlaelvyqkmirsldtte.tveldylslleelrskrkraiht
subfamily_hpo-7_pd Subfamily hpo-7 36-215 1.4e-11 38.8 In-house 43-225 (263) alignment 
Range on Protein: 36-215
Range on HMM: 43-225/263.0
MENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR-E-SDTISFGEYFIKCLSSKDcnGYIERKFNVHS--DKGSSSWNVMQFQVTNWPQDGVIKE
. .|.  |...||  | . .||||  .|.|.| | .|.  |  .   . .  . .  ...    . .  .. |  ..     .| ... . |..    ..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PRTVLQVIDevIHRQQKigggPVVVHCSDTVSRSGVYCSVSIALE------QCKAEGVVDVFQVTKSVRRSKPGAVTTLDQY-SSIYEVIS
.| .|....  . |. |    ..|||||  . ||  .  . ..        .    . .|  .. . .| |...|. |  |   ||. |. 
areilnilk..varnsk....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 12-87 6.5e-11 36.1 In-house 90-164 (349) alignment 
Range on Protein: 12-87
Range on HMM: 90-164/349.0
HGYINASFTAG--YREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESdtiSFGEYFIK
. |||| .     .  .. .|  | |.  || ||.|.|.  .|  .. |   .| . | |..||.|    |. .. .|
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel...sysnitvk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 9-63 3.9e-10 33.8 In-house 67-121 (347) alignment 
Range on Protein: 9-63
Range on HMM: 67-121/347.0
QESHGYINASFTAGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEE
.....|||||       .. .|..| |. .||||||||.   ||. .| .    .
ddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepik
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 27-218 1.5e-09 31.0 In-house 115-309 (346) alignment 
Range on Protein: 27-218
Range on HMM: 115-309/346.0
RAFIIAQSP-ME--NTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESDTISF-GEYFIKCLSSKDCNGYIERKFNVHSDKGSSSWNVMQFQVTn
. .|.|| | ||    | ||| || . ..  . ..   .   .     .  |     . |  ||.   .       |   .|  .  | |  .   . . 
hklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhha.

wPQDGVIKEPRT--VLQVIDEVIHRQQKIGGGPVVVhCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
 |   . . |.|  ....| .    .|    |  ||       |.  .     |..|       ..... |.... .||.| .. ||.||| ..  |.
.pwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 112-220 3.7e-09 30.7 In-house 214-346 (350) alignment 
Range on Protein: 112-220
Range on HMM: 214-346/350.0
SWNVMQFQVTNWPQDGVIKEPRTVLQVID---EVIH------RQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQC---------------KAEgVVD-V
 . |.|.|| ||.  ... .|. .||...   ..|         ..  . |..||||  | | |.....   |..                 |. . | .
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDli

FQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKL
... . .|. .   | .|||.  ||| .  | .|
siivnelrkqrismvqnldqfifiYeallfyfaL
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 153-214 1.9e-08 28.5 In-house 230-291 (297) alignment 
Range on Protein: 153-214
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||.|.  .|...
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 155-220 2.5e-08 28.2 In-house 2-67 (69) alignment 
Range on Protein: 155-220
Range on HMM: 2-67/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKL
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.. .   |||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 12-103 3.3e-08 27.4 In-house 60-154 (332) alignment 
Range on Protein: 12-103
Range on HMM: 60-154/332.0
HGYINASFTAGYREKRAFIIAQSPMEN-TVRDFWKMIVDYKVSAIVMLCGTEEDG-QECCYQYWRESDTISF-GEYFIKCLSSKDCNGYIERKFN
  . |||.  || .| |.|.||.|... |   ||.|. . | | |...   .|   ... |.        ||  |.  | |   . .  | ||| 
ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeksflhefgaksleecelkakicrkfw
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 155-220 4.9e-08 27.2 In-house 1-66 (69) alignment 
Range on Protein: 155-220
Range on HMM: 1-66/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKL
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.. .   |||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 110-219 5e-08 26.6 In-house 215-345 (349) alignment 
Range on Protein: 110-219
Range on HMM: 215-345/349.0
SSSWNVMQFQVTNWPQDGVIKEPRTVLQV-------IDEVIHR--QQKIGGGPVVVHCSDTVSRSGVYCSVSIALE--QCKAEGV--V--------DVFQ
.. . ..|.|| ||.  ... .| ..||        ||.   |   ..    ...||||    |.||.. . . |.  .   .    .         .. 
ekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisi

VTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
.  ..|. .   |  | |.  ||| .  |..
ivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_DSP1_pd Subfamily DSP1 122-209 5.8e-06 20.5 In-house 71-154 (163) alignment 
Range on Protein: 122-209
Range on HMM: 71-154/163.0
NWPQDGVIKEPRTVLQVIDEVIHRqqkigGGPVVVHCSDTVSRSGVYCSVSI-ALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSS
. |.. . .  ..|.. ||||..      .| | .||   .|||   | . .   .... |   |  .  .|. .   | |  | .| .
Dspkadislvfeeviefidevkkk.....nGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyek