Gene PTPRD-52 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP109_AA protein Get Run
AqueP109_AA_32-297 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 42-304 5.1e-122 401.3 In-house 9-301 (301) alignment 
Range on Protein: 42-304
Range on HMM: 9-301/301.0
NPKTRSTGMAAQFGLLQQVTPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKEA-----NGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDY
. ...|.....|.  |............................. ...|.. |..     . ||||||..||.||..||.||.||..| .|||..|...
vaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

KVSAIVMLCGEEDC----SFPYWSTLEKFGEYYVEVTNEIKS---------------------NGYTERMFKVSSEKESRSVLQLQVTDWPQDGIVREPR
|...|||.......    .. ||.. |.  |.....|.....                     |||.||.|||.|.|.|..|||||||||||||.|||||
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

TVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNSMYGN
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||.|.|
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 44-299 6.3e-97 319.4 In-house 18-286 (305) alignment 
Range on Protein: 44-299
Range on HMM: 18-286/305.0
KTRSTGMAAQFGLLQQVtPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKEANG---YINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSA
.. ..|. ||. .|..  ....|.....|.......... .|..|..|.. || ..   ||||||..||..| ..|.||.|..|| .|||..||..||| 
vysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

IVMLC----GEEDCSFPYWSTL----EKFGEYYVEVTNEIKSNGYTERMFKVSS---EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGG
||||.    |..|.   || .     ..|||. ||...| . ..|.|| .|.|    .||||.|||.|.||||..|..... ..|..|..| ..|.|  |
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
 |..||||..|.|.||...|.| ||..|.|.|||||.|.|..|......|.||.||....|..| ...  
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 35-305 2.9e-84 277.4 In-house 7-287 (287) alignment 
Range on Protein: 35-305
Range on HMM: 7-287/287.0
VQKLKAINPKTRSTGMAAQFGLLQQVTPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKE-ANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMI
. .. | .... ..|   || .|.||| .....  | |.    |||... |.||.. | ||.  . ||||....||.||.|||||.||| ||||.|||.|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkli

VDYKVSAIVMLCGE----EDCSFPYWSTLE--KFGEYYVEVTNEIKSNGYTERMFKVSSEK---ESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQ
 | .|.|||||| |    |.  . ||.. .   .||| .|..|| ...||.|| ..|  ..   . ..| | |.|.|.. | | ||.|.| ||.. .. |
ddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNSMYGNF
.| | ...|||||||| ||...|.. .....|| |||.||||| |  |  |||.| | |||. |.|.. .||.  ..| .|
rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 41-301 3.8e-76 250.7 In-house 13-288 (290) alignment 
Range on Protein: 41-301
Range on HMM: 13-288/290.0
INPKTRSTGMAAQFGLLQQvTPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKE-------ANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMI
 . ..  .|. .||. |.. .  .. .. . ..    .||.......| . . |..       .| ||||.|..||.||...|..|.|..||..||||.|
nghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

VDYKVSAIVMLCG-----EEDCsFPYWSTL--EKFGEYYVEVTNEIKSNGYTERMFKVSSEKE---SRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHR
.. ||..||||.      .. |   ||..   ...||. ....|| . |.|.|| ..| ....   ..|| |.|.| |...| | .| |.|.||  ... 
wqekvtiivmltniieegkvkC.qqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemykt

QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNSM
| | | ...||||||||.||.|.|.. .....|| |||.||||| |  |  ||| |.| .||  |....  ||.  . 
qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet
0050432 (Phosphotyrosine protein) phosphatases II 8-301 1.1e-75 250.2 In-house 1-304 (308) alignment 
Range on Protein: 8-301
Range on HMM: 1-304/308.0
YVFLHDAVLEAIICGETEIPTENYMSTVQKLKA-INPKTRSTGMAAQFGLLQQVTPdPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKEANGYINASYL
|....||.||......|.|.....  .|..|   ..... .... ..|  |..|.| .... . . ... .|||.  .|| |.  | |.| ..|||||| 
yllildallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyv

NGY--REKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCS----FPYW-----STLEKFGEYYVEVTNEIKSNGYTERMFKVSS--EKESRSV
.||  . .|.||..|.|..||  |||.|. ...|. ||||. ... .    ..||     .. ...| . |....| . ..|| | ....   ..||| |
dgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtv

LQLQVTDWPQDGIVREPRTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
 ... |.|| .|.  .|. .|. .. | ...   .|||.|||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|.|||  .|... 
thfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall

MYLQMNSM
.||.   .
eylklklt
0051299 (Phosphotyrosine protein) phosphatases II 22-296 7.8e-72 237.5 In-house 1-286 (288) alignment 
Range on Protein: 22-296
Range on HMM: 1-286/288.0
GETEIPTENYMSTVQKLKainpKTRSTGMAAQFGLLQQVTPDpNDIHCNSAKAHASKNRSNEYLPPDKFIVALK-----EANGYINASYLNGYREKRAFI
|.|||..|.....|.||.    ..  ||....|  |....|| ..... . ... .|||.  .|| |.  | |.     | ..||||||..||. ||.||
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

IAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----SFPYW--STLEKFGEYYVEVTNEIKSNGYTERMFKVS------SEKESRSVLQLQVTDWPQD
..| |..||  |||.|. ...|. ||||.....     ...||  .. ...|.. |. ..| . ..|| | ..|.       ..||| | ....|.|| .
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GIVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|.   |. .|. . .|.. ..  ||||||||||. |.|.|... . . ||| ..||.|||... | .|. .||.|.|.|||  .|... .||
gvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 22-300 1.7e-69 229.3 In-house 1-294 (298) alignment 
Range on Protein: 22-300
Range on HMM: 1-294/298.0
GETEIPTENYMSTVQKLKAINPKTRSTGMAAQFGLLQQVTP--DPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKE-----ANGYINASYLNGYREKRA
|.||| .|..  ..|||.|...|.. ||.|..|  |..|.   . .  .  ....  .|||  .... |.  | |..        |||||.|..|... |
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----SFPYWST--LEKFGEYYVEVTNEIKSNGYTERMFKVSSEK--ESRSVLQLQVTDWPQDGI
||..| |...|  |||.|........||||   |.        || .   |..||  |.. .. .   .. | .|||..|  ..|.| ||..| ||. |.
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

VREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNS
 .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  .|.  .
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
0046845 (Phosphotyrosine protein) phosphatases II 50-300 3.6e-69 228.6 In-house 2-278 (284) alignment 
Range on Protein: 50-300
Range on HMM: 2-278/284.0
MAAQFGLLQQVTPDPN-DIHCNSAKAHASKNRSNEYLPPDKFIVALK------EANGYINASYLNGY-----REKRAFIIAQSPMENTARDFWKMIVDYK
. ..|  |...|...  ....  .... ||||.  .|| |.  | ||      | ..||||||..||     . |..||..| |..||  |||.|. ...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VSAIVMLCGEEDC----SFPYWSTLE---KFGEYYVEVTNEIKSNGYTERMFKVSS---EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQK-
|. ||||.....      ..||.. .   ..|.. |....| . ..|| |.....    ..||| | ....|.|| .|.  .|. .|. ...| . ... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNS
 ||||.|||||. |.|.|... . . ||| ..||   .|||... | .|. .||.|.|||||  .|... .||..  
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0036941 (Phosphotyrosine protein) phosphatases II 38-298 2.5e-67 222.6 In-house 3-279 (297) alignment 
Range on Protein: 38-298
Range on HMM: 3-279/297.0
LKAINPKTRSTGMAAQFGLLQQVTPdPNDIHCNSAKAHASKNRSNEYLPPDKFIVALkEANG--YINASYLNGYREKRAFIIAQSPMENTARDFWKMIVD
|| ..... ....  .|  |... . . .. . . ... .|||.  .|| |.  | | . .|  ||||||..||. ||.||..| |..||  |||.|. .
lkllekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

YKVSAIVMLCGEEDC----SFPYW----STLEKFGEYYVEVTNEIK--SNGYTERMFKVSS--EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHR
..|. ||||. ...      ..||        ..|.. |..... .  ...|| | ..|.   ..||| | ....|.|| .|.   |...|. |. | ..
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

QQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
.... .||||.||||. |.|||... . . |.| .    || ||.... | .|. .||||.|||||  .|... ..|. 
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0047943 (Phosphotyrosine protein) phosphatases II 40-296 4e-67 221.9 In-house 4-272 (273) alignment 
Range on Protein: 40-296
Range on HMM: 4-272/273.0
AINPKTRSTGMAAQFGLLQQVTPdPNDIHCNSAKAHASKNRSNEYLPPDKFIVAL-KEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKV
 ..... .|.....| ||....| . .. . . ... .|||.  .|| |.  | |  . ..||||||..||. ||.||..| |..||  |||.|. ...|
llekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

SAIVMLCGEEDC----SFPYWSTLE-----KFGEYYVEVTNEIKSNGYTERMFKVSS--EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKI
. ||||. ...      ..||.. .     ..|.. |....| . ..|| | .....   .||| | ....|.|| .|.   .  .|. |..| . ....
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 ..||||||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|.|||  .|... .||
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 34-298 8.6e-67 221.0 In-house 18-291 (297) alignment 
Range on Protein: 34-298
Range on HMM: 18-291/297.0
TVQKLKAINPKTRSTGMAAQFGLLQQVTPDpndIHCNSAKAHASKNRSNEYLPPDKFIVALKEANG------YINASYLNGYRE-KRAFIIAQSPMENTA
 .  |. ..... .|.. ..|  |....||   . .   ... .|||. ..|| |   | ||  .|      ||||||..||.  .|.||..| |...| 
vldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

RDFWKMIVDYKVSAIVMLCGEEDC---SFPYW-STLEKFGEYYVEVTNEIKSNGYTERMFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIH
 |||.|. ...|..||||. ....    ..|| .. ...|.. |....... .||| | ..|. ..||| | ..|.|.|| .|.   ....|.... | .
edFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvre

RQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
....  .||||.||||. |.|.|...   . |||.. || |||... | .|. .||||.|..||  .||.. ..|. 
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0040438 (Phosphotyrosine protein) phosphatases II 48-301 3.4e-65 215.8 In-house 18-281 (317) alignment 
Range on Protein: 48-301
Range on HMM: 18-281/317.0
TGMAAQFGLLQQVTPDpnDIHCNSAKAHASKNRSNEYLPPDKFIVALKEAN-----GYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIV
|..  .|  |.....|  .. . . ... .|||.  .|| |   | |.  .     .|||||| .|...||.||..|.|..||  |||.|. ...|. ||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLCGEEDC----SFPYW--STLEKFGEYYVEVTNEIKSNGYTERMFKVS--SEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQkiG-GGPVV
||. .|..    ...||   .  ..|.. |....|.. .|.| | ..|.   ..||| | ... |.|| .|.   |...|. .. | . ..  . ||||.
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvl

VHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNSM
||||. |.|.|... . . |||.. || |||... | .|. .||||.|.|||  .||.. .||. . .
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
0045450 (Phosphotyrosine protein) phosphatases II 37-296 5.6e-65 215.4 In-house 16-304 (307) alignment 
Range on Protein: 37-296
Range on HMM: 16-304/307.0
KLKAINPKTRSTGMAAQFGLLQQVTPD-PNDIHCNSAKAHASKNRSNEYLPPDKFIVALK------EANGYINASYL--------NGYREKRAFIIAQSP
.|.......  ||....|  |..||.. .... . . ... .|||. ..|| |   | |.      | ..||||||         .||. ||.||..|.|
llvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

MENTARDFWKMIVDYKVSAIVMLCGEEDCSF----PYW---STLEKFGEYYVEVTNEIKSNGYTERMFKVS---SEKESRSVLQLQVTDWPQDGIVREPR
...|  |||.|. ...|..||||...... .    .||   ..   .|.. |....| . .||| | ..|.    ..||| | ... |.|| .|.   . 
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfe

TVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
..|. |. | . ...  .||||.||||. |.|.|...   . |.| ..||.   ||.... | .|. .||||...|||  .|... ..|
elldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 52-296 4.5e-64 211.7 In-house 4-262 (263) alignment 
Range on Protein: 52-296
Range on HMM: 4-262/263.0
AQFGLLQQVTPDPnDIHCNSAKAHASKNRSNEYLPPDKFIVALKEA-----NGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG
..|  |.. |..  .....  |.  ||||....|| |.  | ||.      . ||||.|..|...|...|..| |...| .|||.|... ||. ||||. 
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

EEDC----SFPYWSTL----EKFGEYYVEVTNEIKSN-GYTERMFKVSSEK--ESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIgGGPVVVH
||..       ||       |.||.. |......| .  .. | .... |.  |.|.| |.|...||. |.  ... ||...  | ......  ||.|||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVh

CSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 52-296 4.5e-64 211.7 In-house 4-262 (263) alignment 
Range on Protein: 52-296
Range on HMM: 4-262/263.0
AQFGLLQQVTPDPnDIHCNSAKAHASKNRSNEYLPPDKFIVALKEA-----NGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG
..|  |.. |..  .....  |.  ||||....|| |.  | ||.      . ||||.|..|...|...|..| |...| .|||.|... ||. ||||. 
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

EEDC----SFPYWSTL----EKFGEYYVEVTNEIKSN-GYTERMFKVSSEK--ESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIgGGPVVVH
||..       ||       |.||.. |......| .  .. | .... |.  |.|.| |.|...||. |.  ... ||...  | ......  ||.|||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVh

CSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 39-296 4.5e-63 208.7 In-house 11-277 (278) alignment 
Range on Protein: 39-296
Range on HMM: 11-277/278.0
KAINPKTRSTGMAAQFGLLQQVTPdpNDIHCNSAKAHASKNRSNEYLPPDKFIVALKE-----ANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMI
 .   ..  |.. ..|  |.....  ... .   ... .|||.  .|| |   | |.       ..||||||..||. .|.||..| |...|  |||.|.
llelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmv

VDYKVSAIVMLCGEEDCS----FPYW-STLEKFGEYYVEVTNEIKSNGYTERMFKVS--SEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQk
 ...|. ||||..... .    ..|| .. ...|.. |....|.. ..|| | ..|.   ..||| |.... ..|| .|.   . ..|. . .|..... 
welgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.

IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  .|||.||||. |.|.|... . . ||| . || ||.... | .|. .||||.|..||  .|... .||
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 76-292 1.1e-61 203.6 Pfam-A 2-233 (235) alignment 
Range on Protein: 76-292
Range on HMM: 2-233/235.0
ASKNRSNEYLPPDKFIVAL---KEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----SFPYWS----TLEKFGEY
 .|||....|| ||  | |   .... ||||.|..||.||..||..| |...|  |||.|....||..||||. .|.       .||.    . ...|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

YVEVT-NEI-KSNGYTERMFKVSSEKES---RSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE
 ||.. .|  ....|| | ......||.   |.| ||..|.||. |. ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. |||.|. | .|...||.|..||||  .|..|
eevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 76-292 1.1e-61 203.6 In-house 2-233 (235) alignment 
Range on Protein: 76-292
Range on HMM: 2-233/235.0
ASKNRSNEYLPPDKFIVAL---KEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----SFPYWS----TLEKFGEY
 .|||....|| ||  | |   .... ||||.|..||.||..||..| |...|  |||.|....||..||||. .|.       .||.    . ...|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

YVEVT-NEI-KSNGYTERMFKVSSEKES---RSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE
 ||.. .|  ....|| | ......||.   |.| ||..|.||. |. ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. |||.|. | .|...||.|..||||  .|..|
eevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 74-302 4.6e-60 197.9 In-house 8-248 (250) alignment 
Range on Protein: 74-302
Range on HMM: 8-248/250.0
AHASKNRSNEYLPPDKFIVALKEAN-----GYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG--EED-CSFPYWS--TLEKFGE
.   |||  .... |.  | |.. .      |||||.|.||.|..|||..|.|...|  |||.|....|...||||    |..     ||   . ||.|.
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGd

YYVEVTNEIKSNGYTERMFKVSSEKESRS--VLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV
  |.. .. .   || | .|.|..|.. .  | ||. . ||  |. .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | | |
vtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekv

VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNSMY
||||.| |..|. .|.||..|||| ..| .|  .|.  . |
vdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedy
0040439 (Phosphotyrosine protein) phosphatases II 66-296 8.9e-60 197.7 In-house 2-246 (249) alignment 
Range on Protein: 66-296
Range on HMM: 2-246/249.0
DIHCNSAKAHASKNRSNEYLPPDKFIVALKE-----ANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC-------SFP
.. . . ... .|||.  .||.|   | |.       ..||||||..||. ||.||..| |...|  |||.|. ......||||. .. .        .|
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

YwSTLEKFGEYYVEVTNEIKSNGYTERMFKVS--SEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVS
  ..  ..|.. |..........|| |.....   ..||| ||..|.|||| .|.   . ..|. |. | . ....  ||||.||||. |.|.|...   
l.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

IGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
. ||| . |. ||.... | .|. .||||...|||  .|... ..|
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPRD_pd Subfamily PTPRD 98-299 2.2e-59 196.6 In-house 76-284 (564) alignment 
Range on Protein: 98-299
Range on HMM: 76-284/564.0
NGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCSF----PYWSTL--EKFGEYYVEVTNEIKSNGYTERMFKV--SSEKE
  |||||...|||...|.| .| |...| .|||.|. ....| ||||   |. .      || .   |..||. |....| . . |. | ||.  ....|
sDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkksse

SRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
|| | | . |.||. |.  .....|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | | |||  |.
sreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFih

DVIDMYLQMN
..|  .|.. 
eailealacg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 48-302 9.4e-59 194.0 In-house 20-286 (318) alignment 
Range on Protein: 48-302
Range on HMM: 20-286/318.0
TGMAAQFGLLQQVTPDPNDIHCnSAKAHASKNRSNEYLPPDKFIVALKEAN-----GYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIV
. . ...  |....  .  ..    .. . ||| .  |. |.  |.|.. .      ||||.|..|||.|.|.| ||.|. .| .|||.|. . . . ||
lllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLCGEED-CS---FPYWST--LEKFGEYYVEVTNEIKSNGYTERMFKVSS--EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGGGPVVV
||  ||. .      ||     ...|.  ||...|.... |. | |||.   |.||| | | ..|.||. |.  .. ..|... .| . ||| | ||.||
mltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivv

HCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNSMY
|||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | .||. ||||.  .|.   ..
hCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 50-299 1.9e-58 193.0 In-house 25-286 (319) alignment 
Range on Protein: 50-299
Range on HMM: 25-286/319.0
MAAQFGLLQQVTPDpnDIHCNSAKAHASKNRSNEYLPPDKFIVALKEANG-----YINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVML
.. .| ||.. ..|  ...  | .   .||| .. |. |.  |.|.| .|     |||||...||.|...|| .|.|.|||  |||.|. ....| .|||
lekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvml

CGEED-----CSfPYWSTLE--KFGEYYVEVTNEIKSNGYTERMFKV---SSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGGGPVVV
..  .     ..  ||.. .  ..|.. |.. .| . ..|  | .|.   ||| |.|.| . | |.||.... .. ...|... .. . ..|   ||.||
tklveklkvklk.kywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivv

HCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
|||. | | | .. ... ||. | |||.|||.. . .|  ..  | . |||. ||...  .... 
hCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
0045098 (Phosphotyrosine protein) phosphatases II 51-298 3.2e-56 186.1 In-house 9-274 (278) alignment 
Range on Protein: 51-298
Range on HMM: 9-274/278.0
AAQFGLLQQVTPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVAlkeanGYINASYLNGYreKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC
. . .  . ....|..| ..    ...|||  ..|| |   |      .||||||..||  ...||..| |...|. |||.|. ......||||..... 
lllefefllllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

S----FPYWST--LEKFGEYYVEVTNEIKSNGYTERMFKVS------SEKESRSVLQLQVTDWPQDGIVREP--RTVLQVIDDVIHRQQK----------
.    ..||     . .|.. |....|   . || |...|       .. ||| | .|. . ||  |.  .|  . .|.... . .....          
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

--IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVIDMYLQM
   .||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..||||  .|... ..|..
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0042113 (Phosphotyrosine protein) phosphatases II 69-296 4.1e-56 185.5 In-house 3-243 (245) alignment 
Range on Protein: 69-296
Range on HMM: 3-243/245.0
CNSAKAHASKNRSNEYLPPDKFIVALKEANG-----YINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCS----FPYW--ST
. . ... .|||. ..|| |   | |.. .|     |||||| .||| .. ||..| |...|  |||.|. ......||||. ||. .    ..||  ..
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

LEKFGEYYVEVTNEIKSNGYTERMFKVS--SEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQ
  ..|.. |....| . ..|| | ..|.   ..||| |.... ..|| .|.   ....|.... | . ... ..|||.||||. |.|.|... . . |||
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 ..|. |..... | .|. .||||.|..||  .|... ..|
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Ptp69D_pd Subfamily Ptp69D 45-295 1.9e-55 183.1 In-house 17-285 (307) alignment 
Range on Protein: 45-295
Range on HMM: 17-285/307.0
TRST--GMAAQFGLLQQVtPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKEANG-----YINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYK
 | |  |.|  .  |..    . . .    |  | |||...  . ||  | ||. ||     |||||...||.||. ||.|| |.|.|. |||.|| . .
krdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

VSAIVMLCGEEDCSF----PYWS--TLEKFGEYYVEVTNEIKSNGYTERMFKVSSEK-------ESRSVLQLQVTDWPqDGIV-REPRTVLQVIDDVIHR
|  ||||  ... .      ||.  .  ..|.  |.. .| | . |..| ..||  |       .|| |.| . | |. | .| . .|..|..|. | . 
vtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrel

QQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
...   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  .  |
ykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_PTPRA_pd Subfamily PTPRA 72-300 1.3e-52 173.8 In-house 55-300 (330) alignment 
Range on Protein: 72-300
Range on HMM: 55-300/330.0
AKAHASKNRSNEYLPPDKFIVALKEANG-----YINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCSFPYWST--LEK
 .    |||  . || |   | | . .|     |||||...||.||  || || | |.|  |||.|| ..| ..||||      .|.    || .  |  
keenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvt

FGEYYVEVTNEIKSNGYTERMFKVS------SEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIGLE
.|.  ||| .|  .. || | | |        ||.|| | |.  | ||. |.  ||. .|...  | . .|. .| |.|||||  | |.| .. ..  ||
yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavle

QCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY-LQMNS
. |||..||||.. | .|  .|  | |.|||. || |.  | |  ..
rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 46-292 2.4e-52 172.6 In-house 4-262 (283) alignment 
Range on Protein: 46-292
Range on HMM: 4-262/283.0
RSTGMAAQFGLLQQVTPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALK-EANGYINASYLN---GYREKRAFIIAQSPMENTARDFWKMIVDYKVSAI
|.... ...  |....  . |  ..||. .  ||| .| .| |...| || |.. ||||...     |.... .||||||...| .|||||. | |..||
rvnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

VMLCG-----EEDCSfPYWST--LEKFGEYYVEVTNEIKSNGYTERMFKVSSE---KESRSVLQLQVTDWpqdgIVREPRTVLQVI---DDVIHRQQKIG
|||       .. ||  ||     |..||. | . .|  || .. . . .  .   |..  .   || ||    .  .. ...  .   . ||  |..  
vmltklqedlrikCs.qyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqtesk

GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||.||||| .. |..|....|  ... ..| |||||.| | .|  ...|| ||.||  .....
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_CG7180_pd Subfamily CG7180 56-298 3.4e-50 165.4 In-house 21-292 (296) alignment 
Range on Protein: 56-298
Range on HMM: 21-292/296.0
LLQQVTP--DPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKEANG-----YINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE
|. ..||  . .|  ..  |    |||  . .|.|.. | |.. .|     ||||.| ...  |...|. . |...|  .||... | ..||.|.|. . 
lelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktf

DCSF---PYWSTL--EKFGEYYVEVTNEIKSNGYTERMFKVSSE------------KESRSVLQLQVTDWPQ-DGIVREPRTVLQVIDDVIHRQQKI---
| .     ||     |..||  ||...| .    . |.||.  .             | | |...|.| |.  | .     ......  |   ..|.   
dfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvded

-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
   |||||..|| .||||||... . ||. . |. ||||.  | .|||.|. | . |.|  ||||.  .. .
peegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_PTPRK_pd Subfamily PTPRK 73-292 1.1e-49 164.0 In-house 41-273 (314) alignment 
Range on Protein: 73-292
Range on HMM: 41-273/314.0
KAHASKNRSNEYLPPDKFIVALKEA-----NGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCS----FPYWS-TLEKFG
. . .||||.. |..|.  | |.       . ||||.....|.  .|||..| |...| .|||... |.. ..||||    . .      ||    |..|
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevyg

EYYVEVTNEIKSNGYTERMFKVSS----EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.  ||. .    . .  |.|.|.      .| | | |.| . ||. ..  . ...|...  | . |.. . |..|||||    |.|... ..| |.  . 
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmier

EGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|||||||.. |..| .|.  | | |||. |||||
egvvdvfnavktlrsrkvnmveteeqykfiydvi
0037934 (Phosphotyrosine protein) phosphatases II 68-295 1.3e-49 164.3 In-house 3-241 (243) alignment 
Range on Protein: 68-295
Range on HMM: 3-241/243.0
HCNSAKAHASKNRSNEYLPPDKFIVALKEaNGYINASYLNGYreKRaFIIAQSPMENTARD----FWKMIVDYKVSAIVMLCGEEDC----SFPYWSTLE
.. . ... ||||   .|| |   | |.  ..||||.. ...  .| .|. | |...|  |    ||.|. ......||||. ...      ..||.  .
siallpenlsknrysdilpydhsrvkleg.sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgev

KFGEYYVEVTNEIKSNGYTERMFKVSS---EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYCSV
 .|.. |....|   ..|| |.....    ....| | ... . ||  |.  .|  .|. .|.|.  ...        .||||.||||  |.|.|...  
tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaa

SIGLEQCkaeGvVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVIDMY
 . |...   | ||.... | .|. .|| ||.|..||  .|... ..
ylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRG_pd Subfamily PTPRG 27-293 2e-48 160.0 In-house 2-284 (563) alignment 
Range on Protein: 27-293
Range on HMM: 2-284/563.0
PTENYMSTVQKLKAinpkTRSTGMAAQFG-LLQQVTPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKEANG------YINASYLNGYREKRAFIIAQ
| ... . | .|.|       .|....|  | ......  |..  ...    |||  . .. |.  | |..  |      ||||.|..||. ..|||..|
pvkefakhvaslha....dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatq

SPMENTARDFWKMIVDYKVSAIVMLCG-----EEDCsFPYWST--LEKFGEYYVEVTNEIKSNGYTERMFKVSS-----E---KESRSVLQLQVTDWPQD
 |...|. |||.|| . .|. |||.        ..| . || .   |..|.  |  ..| .   ||.| ...       .   .. . | | . |.||. 
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkc.dvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdh

GIVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
|    .  ||. .     . .|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |||. ..|.. 
gvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 75-292 1.5e-47 157.1 In-house 49-275 (315) alignment 
Range on Protein: 75-292
Range on HMM: 49-275/315.0
HASKNRSNEYLPPDKFIVAL-----KEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCSFPYWSTLE-KFGEY
   |||  . .. ||  | |     ..   |.||....||  || .| ||.|  .. .|||... ..... |||| .    |.  .  ||   .  .|..
nkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGki

YVEVTNEIKSNGYTERMFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDV
 |   .| . . || | . | .... | |.||..| ||. |. .   .....|  |   ...   |..|||||. | |.| .....  |.| .|| ..||
tvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidv

FQVTKAVRRSKPGAVTTLEQYTSIYDVI
... . ||. . ..| ..|||  |||..
ynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 41-293 1.8e-47 156.8 In-house 14-276 (288) alignment 
Range on Protein: 41-293
Range on HMM: 14-276/288.0
INPKTRSTGMAAQFGLLQQVTPDPNDIHCNSAKaHASKNRSNEYLPPDKFIVALKE-----ANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVD
.  ..  ||.  ..  | ..  . ..   . |.  |.||| .. || |   | ||.      . ||||||..|...|...| .|.|. .|  |||... .
kksarnrtgfseeynsLaalektksvtagrlav.nakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

YKVSAIVMLCG-----EEDCSfPYWSTLEK---FGEYYVEVTNEIKSNGYTERMFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKI
.|.| |||| .     .. |   || . .|   .|.  |..... . . ...| . .  .|. . . |.| . ||..|. .  . .|.... |   .|. 
nktstivmltelveggktkCe.eYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

gGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
  ||..||||. | |.|.. ..   ... ..| ..||. . . .|....  | ||.||  ||.|. 
.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 62-291 2.8e-47 156.6 In-house 48-286 (319) alignment 
Range on Protein: 62-291
Range on HMM: 48-286/319.0
PDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKEANG-----YINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCgEEDCSfPYWS
..  |      .    |||  . |. || .| |.  .|     |||||...||. |  .| || |..||  |||.|| .|..|.||.|  .. ||  || 
vnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.kdkcs.qywp

--TLEKFGEYYVEVTNEIKSNGYTERMFKVSS---EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVS
  . .| ... |.|.   ... |. | ...|    ||. |.. |     ||. |    |  ...... | | ..|  .  ..|||||  | |.|||  . 
lkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld

IGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
. |.. | |  |||... . .|. ..  |  | ||  ||  
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_PTPN6_pd Subfamily PTPN6 29-300 4e-47 155.7 In-house 7-301 (306) alignment 
Range on Protein: 29-300
Range on HMM: 7-301/306.0
ENYMSTVQKLKAINPKTRSTGMAAQFGLLQQVTPDPNDIHCNSAK-AHASKNRSNEYLPPDKFIVALKE--AN--GYINASYLNGY--REKRAFIIAQSP
..  . |..|.  . ..  .|.  .|  |||        . ..||   ..||| .  || |.  | |||       ||||.|...    .....| .|  
keieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgc

MENTARDFWKMIVDYKVSAIVMLCGE-----EDCsFPYWS---TLEKFGEYYVEVTNEIKSNGYTERMFKVS---SEKESRSVLQLQVTDWPQDGIVREP
.|.|  |||.|... .   |||.  |     | |  .||    . |..|.. |. ..| . . |. | ..||   ..||.|.| |.. ..||. |. ..|
lettvsdFWrmvwqensrvivmttkevErgkekC.arYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdp

RTVLQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNS
 .||. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | | .||  .| .| .|.. ..
gavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 74-291 8.4e-47 155.0 In-house 24-250 (284) alignment 
Range on Protein: 74-291
Range on HMM: 24-250/284.0
AHASKNRSNEYLPPDKFIVALKEANG-----YINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCgEEDCSfPYWS--TLEKFGEYYV
    |||  . |. || .| |.   |     |||||...||. |  .| .| |..||  |||.|| .|..|.||.|  .. ||  ||   . .| ... |
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.kdkcs.qywplkivikeerfkv

EVTNEIKSNGYTERMFKVSS---EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV
.|.   .|. |. | ...|    ||. |.. |     ||. |    |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |
kvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqv

DVFQVTKAVRRSKPGAVTTLEQYTSIYDV
||... . .|. ..  |  | ||  ||  
dvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 73-299 1.2e-46 154.2 In-house 47-287 (297) alignment 
Range on Protein: 73-299
Range on HMM: 47-287/297.0
K--AHASKNRSNEYLPPDKFIVALKEAN-----GYINASYLNGYREkrAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE----EDCSfPYWS--TLE
.     .|.| .  || |.  | |.  |      |.|||...|...   .|  | ||..|  |||.|..|..||.||||  .    . |   |||  .  
ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkca.ryWsdkgvt

KFGEYYVEVTNEIKSNGYTERMFKVSSEK--ESRSVLQLQVTDWPQDGIVR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQ
.||.  |...   . .|. .| ..|. .|    | | | | ..||.. . |  . ...|..|..| .  ..   ||..|||.  | | ||....   . .
tfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvae

CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
 | |  ||.|.. | .|...|  | | |||. .| ..  .|  .
akrekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_PTPRB_pd Subfamily PTPRB 30-297 1.5e-46 153.8 In-house 11-286 (293) alignment 
Range on Protein: 30-297
Range on HMM: 11-286/293.0
NYMSTVQKLKAinpkTRSTGMAAQFGLLQQVTPDpNDIHCNSAKAHASKNRSNEYLPPDKFIVAL-----KEANGYINASYLNGYREKRAFIIAQSPMEN
.. . |.|.||       .... ..  |..|  | . ........ ..||| .. || |.  | |     .. . ||||.|..||. .| || .| |. .
kfeehvkkmka....dsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TARDFWKMIVDYKVSAIVMLC-----GEEDCSfPYWSTL---EKFGEYYVEVTNEIKSNGYTERMFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQV
|  |||.|. . |.|.||||      | . |   || .      .|.  |....| . . .. | .|.. |||.|.| |.. | ||. |.  ...|.|. 
tvddfWrmvwekkssiivmltqlvekgkvkCe.eYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldf

IDDVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.  | ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .|.
vrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 60-298 2.3e-46 153.1 In-house 27-279 (315) alignment 
Range on Protein: 60-298
Range on HMM: 27-279/315.0
VTPDPNDIHCNSAK--AHASKNRSNEYLPPDKFIVAL-----KEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE--DC
  |||.  . ..|.     .||| .. || |.  | |     .  . ||||||.... . .|.| .| | . .  |||.|....||..|||.   .  | 
dlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdk

--SFPYWST----LEKFGEYYVEVTNEIKSNGYTERMFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSG
     ||      . .||.. ||. .     . . | . .   .||| | | | |.||. |. ..  ..|..| .|    ..    ...||||  | |.|
ikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtG

VYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||..  .|. 
vvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllw
subfamily_PTPN12_pd Subfamily PTPN12 69-297 2.3e-45 149.7 In-house 34-278 (290) alignment 
Range on Protein: 69-297
Range on HMM: 34-278/290.0
CNSAKAHASKNRSNEYLPPDKFIVALKE-----ANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED-----CSfPYWSTL
. ... .  |||  . || ||  | |..      ..||||....|  .| ..| ||.|. .|  |||.|| ...|. .||.| | .     |   ||.  
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe.rYWpee

----EKFGEYYVEVTNEIK-SNGYTERMFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGL
     .|||. |....| . ..... |..||  .||||.| |.. |.||  |. . . ..|..|..| ..|.     |.|||||  | | |. ... .  
geeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvr

EQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
|. ||| .   .|||..   .|. .. .| | |||. .|  .  ..|
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 77-297 2.1e-44 146.5 In-house 45-277 (515) alignment 
Range on Protein: 77-297
Range on HMM: 45-277/515.0
SKNRSNEYLPPDKFIVAL-----KEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG--EEDCS--FPYWST----LEKFGE
.||| .. || |.  | |     .  . |.||||....   .|.| .| | . .  |||.......|..|.|.    |.| .    ||        |||.
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGs

YYVEVTNEIKSNGYTERMFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD
. ||.       | . | ..|  ...|| | | . |.||. |. .. ...|..| .|   ....   |...|||  | | ||..|.   . . |   .||
ikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvd

VFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
||.. . .|. .|  | | |||. ||...  .| 
vfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 73-298 2.9e-44 146.2 In-house 26-270 (274) alignment 
Range on Protein: 73-298
Range on HMM: 26-270/274.0
KAHASKNRSNEYLPPDKFIVALK------EANGYINASYLNGYRE-KRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE-----DCSfPYWSTLE-
  ...||| .. || ..  | |.      |   |||| |. ||.| ..|.. .| |. ||  |||.||   .|. ||||   .      |.  |. . | 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCa.vyfPdaed

-----KFGEYYVEVTNEIKSNGYTERMFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIG
     ..|.  ..|.. .. |.|. | . ... ...|||     ||||     ....|.|.....| . ...     .|||||||  . | |.. ..||.
yeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
. | ..|.||||....  .|  . | | | |||  |. .. .||. 
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPRD_pd Subfamily PTPRD 1-159 2.9e-43 143.3 In-house 263-431 (564) alignment 
Range on Protein: 1-159
Range on HMM: 263-431/564.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTVQKLKAINPKTRSTGMAAQFGLLQQVTPD-PNDIHCNSAKAHASKNRSNEYLPPDKFIVAL-----
|||| .||.|.|.|.|||. ||.||...||. ...|||. ....|..||... |  |.  ... ...  .   .    |||  . |. ..  | |     
mVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsaira

KEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED----CSFPYWSTLE
||   |||||||..|||||||| .|.|..||  |||.|.....|  ||||.. |.    .|. |.| ||
keesdyinasyleayrekrafiatqaplkntvedfwrmvweeevkiivmltkleekleeesseyysdle
subfamily_PTPN23_pd Subfamily PTPN23 47-293 2.6e-42 139.6 In-house 14-277 (288) alignment 
Range on Protein: 47-293
Range on HMM: 14-277/288.0
STGMAAQFGLLQQVT-PDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKE-ANGYINASYLNGYREK-RAFIIAQSPMENTARDFWKMIVDYKVSAIVM
 |.. ..| .|.|    . ..  .  || ...||||.. || |.  | |..  . |||||....       ||..|.|...|. |||.|... |.| |||
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVm

LCGEEDCSFP----YWST----LEKFGEYYVEVTNEIKSNGYTERMFKVSSEK--ESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIH---RQQKIGGG
|  .|.   |    || .     .|||.. | . .. ... . ||..|.. ..  . .||  ||.| ||. |.   | |.||..| | .    .|.    
llskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt

PVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
|.|||||  | |.||.. |   ...  | .|..|. || . .|. .   | . ||.   |... 
PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 48-295 2.2e-41 137.1 In-house 23-287 (325) alignment 
Range on Protein: 48-295
Range on HMM: 23-287/325.0
TGMAAQFGLLQQVTPDpnDIHCNSAKAHASKNRSNEYLPPDKFIVA---LKEA--NGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIV
 |.| .||||  . .     .     .  .||| .. .. ||  |    .|..    |||||||. ...|  |. ||.|. .|  |.|....|.. | .|
dgfahefgllpsddgi..akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvv

MLC---GEEDCSFPYWSTL----EKFGEYYVEVTNEIKSNGYTERMFKVSSEK--ESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKI-----G
.|    ...|    ||        .||   |..    .   |  |...|   |  |.||| |.|.  |.. |  . | |.. ... | . ....     .
vlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantka

GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
 .|..||||. | |.||. |.   |..   |  ||.|.. | .|. .|  | | .||. ||. .  .
stpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 50-295 5.7e-41 135.3 In-house 8-258 (267) alignment 
Range on Protein: 50-295
Range on HMM: 8-258/267.0
MAAQFGLLQQVTPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKE-ANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC--G
.  .| |....... . | .  |.  . .|| .. || |. .| |..  . ||||||..||. |.|||. | |..||  ||...| |.||. ||.|   .
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvf

EEDCSFPY---WSTLEKFGEYYVEVTNEIKSNGYTERMFKVSSEKESRSVLQLQVtdWPQDGIVREPRTVLQVIDDVIHR-QQKIGGGPVVVHCSDTVSR
...    .       .|. .  || . | . | |    ...  ..||   . |    . .  |  . .  |. .  .. . | . |. |.||.||| | |
tdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyy..ykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGr

SGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
|| .  .   ||. | |||.|.|.  . .|  ..| | |.|.|  |....  |
sGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_PTPN9_pd Subfamily PTPN9 35-295 9e-41 134.8 In-house 3-289 (297) alignment 
Range on Protein: 35-295
Range on HMM: 3-289/297.0
VQKLKAINPKTRSTGMAAQFGLLQQVTPDpNDIHCNSAKAHASKNRSNEYLPPDKFIVALKEAN-----GYINASYLNGYREKRAFIIAQSPMENTARDF
...| |   ...  |.  ..  ... ..    ...   .|  .||| .. |  |.  | |.. .      ||||....||..|.||| .| |...| .||
ieelvayvkekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WKMIVDYKVSAIVMLC-----GEEDCSfPYWS----TLEKFGEYYVEVTNEIKSNGYTERMFKVS--SEKESRSVLQLQVTDWPQDGIVREPRTVLQVID
|.|. . .|  |||       |   |.  ||     . ..||.. |.. .  ... |..|.....   ..|||.|   |.. ||  |. ..  ..|.|..
WrmvWeqevlvivmttrvvergrlkcg.qyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

DVIHRQQ------------KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
 | ..|             .. | |.|||||  . |.| .... | |.. . .|.|||... | .|  .  .. | |||.  |  .  |
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 48-297 3.3e-40 133.0 In-house 15-277 (281) alignment 
Range on Protein: 48-297
Range on HMM: 15-277/281.0
TGMAAQFGLLQQVTPDpNDIHCNSAKAHASKNRSNEYLPPDKFIVAL-----KEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIV
.|.. ..  |...  | |  .   |..   ||| .     |.  | .     .. . ||||....||......|..|.|. ..  .||.|....||||||
aGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLCGEEDC----SFPYWSTLE---KFGEYYVEVTNEIKSNGYTERMFKV-SSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGGGPVVV
|.  | .        ||   .   |.|.. |. |.| ... | || ||.  .. |.|.| ||. | ||. |.  ... .|.  ..| . ..|    |.|.
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
|||  | |.|.| ..   .....||   .|| .| . .|...   | |. ||. .| ..  .|.
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 75-299 6.8e-40 131.8 In-house 20-267 (270) alignment 
Range on Protein: 75-299
Range on HMM: 20-267/270.0
HASKNRSNEYLPPDKFIVALKEA-----NGYINASYLNGYRE-KRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC-----GEEDCSFpYWSTLEK---
..  ||... ||  .  | |.|        |||| |..|. . |...| |..|...| ..||.||.. ||.||||.      | . |.  ||..  |   
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCer.YWpaepkekv

---FGEYYVEVTNEIKSNGYTERMFKVSSEKESRSVLQLQVTDWPQDGIVREPR------TVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVS
   .|.  | ...| |..||  .  .. .. |.| ..  . ..||..|..||.        .|... .|  .....  ..|..||||. | |.|.   . 
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

IGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
|...  . .. ||| .. ...|. ..  | . |||. .| .. .| .. 
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN3_pd Subfamily PTPN3 48-292 1.3e-38 127.5 In-house 15-271 (280) alignment 
Range on Protein: 48-292
Range on HMM: 15-271/280.0
TGMAAQFGLLQQVTPDPNdIHCNSAKAHASKNRSNEYLPPDKFIVALKEAN-GYINASYLNG----YREKRAFIIAQSPMENTARDFWKMIVDYKVSAIV
  . |||  | .  |. . |..    . .||||  . || |.  | |||..  ||||.|.|           .|..| |...|| |||.|. . |.| ||
Gavlaqfeqlyrkkpgla.isaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLC-----GEEDCSfPYWSTL---EKFGEYYVEVTNEIKSNGYTERMFKVSSEK--ESRSVLQLQVTDWPQDGIVREPRTVLQVIDDViHRQQKIGGGPV
||      |   |   || .     ..||. |....| ... |  | . .. ..  |.|..|||| ..||. |.  ..  .|.... | .....    ||
mlttlverGrvkCh.qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePv

VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|||||  . |.||.  . . |    |.  | . .. . .|  .   | | .||. . . |
vvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 52-295 8.7e-38 124.9 In-house 24-278 (439) alignment 
Range on Protein: 52-295
Range on HMM: 24-278/439.0
AQFGLLQQVTPDPNDIHCNSAKAH-ASKNRSNEYLPPDKFIVALKEANG-----YINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC
  |  .. . || . | .  |. .  .||| ..  . |   |.|.|  |     |||| |..|| ... .| .| | ..|. |||..... |.. ||||.
eifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmlt

GEEDcSFPYWSTLEK--FGEYYVEVTNEIKSNGYTERMFKVSSEK----ESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDT
   . |. || . ..  .|.  | |  .|.   |. | |||  |.      |.|||.. . ||.  .  .   ||. .  .   ..|   ||||||||  
nlve.sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsag

VSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
| |.|   .. | ||| |.|  ||.  . | .|. .   | .| ||  ||. .   
vGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_PTPN13_pd Subfamily PTPN13 52-297 8e-37 122.0 In-house 15-270 (273) alignment 
Range on Protein: 52-297
Range on HMM: 15-270/273.0
AQFGLLQQVTPDPNdIHCNSAKAHASKNRSNEYLPPDKFIVALKEANGYINASYLNGY--REKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED
 .|  |... |  .  .    |.. .|||  . || |.  | |..  ||||||...     ..  .|..| |. .|..|||.|. . |.. |.|.  | .
eefkelrelkpldt.cevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtleke

C----SFPYWST-----LEKFGEYYVEVTNEIKSNGYTERMFKVSS--EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSD
        ||       |   . . ||. .  | .|.. | ..|.    .||| | .|. ..||  |. ...  .||..  | . |.    ||.||||| 
kgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsa

TVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
 . |||.. .. . |.  . .  .|| .. . .|. . | | | .||  .| .|   |.
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN14_pd Subfamily PTPN14 65-297 1.2e-36 121.2 In-house 39-297 (300) alignment 
Range on Protein: 65-297
Range on HMM: 39-297/300.0
NDIHCNSAKAHASKNRSNEYLPPDKFIVALK----EANGYINASYLNG--YREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE----EDCSFPY
 .... . .  |.||| .. || ..  | |.    . .|||||| ..     ..| .|.||.|.|.| .|||.|. . .|. ||||  |     . || |
allstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WSTL------EKFGEYYVEVTNEIKSNGYTERMFKVS--SEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDV---IH-RQQKI----GGGPVVVHCSD
.  |       .||.. |      .|. .. . .|.     || |.|. || ||||..|. ..... |. ...|    .  ....       ||.||||.
fPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsa

TVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
 | |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.|.  ||.
GvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0051429 (Phosphotyrosine protein) phosphatases II 98-296 1.3e-36 122.0 In-house 4-225 (272) alignment 
Range on Protein: 98-296
Range on HMM: 4-225/272.0
NGYINASYLNGYRE---KRAFIIAQSPMENTARDFWKMiVDYKVSAIVMLCGEEDCS----FPYWS--------------TLEKFGEYYVEVTNEIKSNG
.|||||....||     ..... .. |...||.|||..  ......||.|..|| .     ..||               .   .| ..| .. |.  . 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YTERMFKVS---SEKESRSVLQLQVTDWPQDGIVREPrtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD--------VF
|. |.. ..   | .|.| |..|. |||| .|. .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
.. . .|.  |||| | |||  .|...  .|
eaveelraqrpgavqteeqylflyeallell
0041856 (Phosphotyrosine protein) phosphatases II 77-298 4.6e-35 116.2 In-house 3-173 (182) alignment 
Range on Protein: 77-298
Range on HMM: 3-173/182.0
SKNRSNEYLPPDKFIvalkeANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCgeedcSFPYWStlekfgeyyvevtneiksng
.|||  ..||.|  .      . ||||... |..  . ||..| |. .|  ||..|. ......||.|.     ...||                     
dknrysdilpydhsr.....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp....................

ytermfkvssEKESRSVLQLQVTDWPQDGIVRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQVTKAVRRSKP
          |.. | ..|.. . || .|.   ....|. |..|..      ||||.||||  |.|.|...   . ...    | |..... | ||. .|
..........ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRp

GAVTTLEQYTSIYDVIDMYLQM
|.|.|..||  ..... ..|. 
gmvitpnqyfflqlallellll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 73-300 5.6e-34 112.2 In-house 36-281 (287) alignment 
Range on Protein: 73-300
Range on HMM: 36-281/287.0
KAHASKNRSNEYLPPDKF--IVALKE--ANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE-EDCS---FPYWSTLEK---F
 | ..|||  . || |.   ... .      |||| |. .|... ||| ||.|.  | ||||..... ........  | |..    . ||   |.    
laavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

GEYYVE-VTNEIKSNGYTERMFKVSS--EKESRSVLQLQVTDWPQDGIVRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLE
| | |  .  .||.  |. | ...     .|.| | ||.. .||....        | ||.| . .  ...  . ||.|||..  . |||.. .. . ..
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNS
. .  | ||| .|   .|  . . | .  |.  .|. .  | . | 
rledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnp
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 62-292 1.4e-33 110.8 In-house 30-232 (392) alignment 
Range on Protein: 62-292
Range on HMM: 30-232/392.0
PDPNDIHCNS--AKAHASKNRSNEYLPPDKFIVAL-----KEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG--EEDcsf
|.|.  . ..   .    ||| .. || |.  | |        . |.||||....  ..|.| .|.|   .  |||.|. . .|..|.|.    | |   
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...

pywstlekfgeyyvevtneiksngytermfkvsSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIG
                                   .. |.| | ..|.||.... .   ..|..| .|     .    |...|||  | |.||  |.   
.................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsv

LEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. ..|   .||||..   .|| .|  | | |||. ||  .
vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 78-292 2.8e-33 110.1 In-house 6-235 (237) alignment 
Range on Protein: 78-292
Range on HMM: 6-235/237.0
KNRSNEYLPPDKFIVALKEAN---GYINASYLNGYRE-KRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCSFPYWSTLE---KFGEYYV
|||  .    |.  | || |     ||||.||.|.    . .| || |.|..  |||.|. . | | |||| |    .|     ||   .    .| . |
knrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltv

EVTNEIKSNGYTERMFKVSS---EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV
 .. . .   || | . .|     || | . | | | ||. |. ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . ||
slkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvv

DVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|...  ...   .|  . | .||  |...|
diynyvysieedrpyiiqtkdqyvfihqti
0036282 (Phosphotyrosine protein) phosphatases II 98-290 3.1e-32 107.0 In-house 2-164 (174) alignment 
Range on Protein: 98-290
Range on HMM: 2-164/174.0
NGYINASYLNGYREKRAFIIAQSPMEntardFWKMIVDYKVSAIVMLCGEEDCS----FPYWSTlekfgeyyvevtneiksngytermfkvSSEKESRSV
. |||||.|....  . .|. | |..     ||.|. .......|||. |.       . ||..                            .| ..|..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...........................lredlerlg

LQLQVTDWPQDGIVREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
.|.. . || .|    .  .|.... | . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
iqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0043147 (Phosphotyrosine protein) phosphatases II 97-291 3.3e-32 107.0 In-house 4-156 (172) alignment 
Range on Protein: 97-291
Range on HMM: 4-156/172.0
ANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEedcsfpywstlekfgeyyvevtneiksngytermfKVSSEKESRSVLQL
 . |||||||..|.  . ||. | |. ||  |||.|. ......||.|...                                    .  |...|...|.
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...................................lydpellerlgiqy

QVTDWPQDGIVrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
. . ||  |    .. .|.... . .....  ||||.||||  |.|.|. .   . |        . ..... . ||. .||||.. .||  .|. 
lylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyf
subfamily_PTPN1_pd Subfamily PTPN1 57-289 1.2e-30 101.2 In-house 12-264 (290) alignment 
Range on Protein: 57-289
Range on HMM: 12-264/290.0
LQQVTPDPNDIHCNSAKAHASK--NRSNEYLPPDKFIVALKE-ANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EED
..... . .|.....|| .. .  ||  .  | |.  . |..  | ||||| ..  . || .|..| |. ||.  ||.|. . |  |.|||      |. 
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

CSFPYWSTLEK-----FG--EYYVEVTNEIKSNGYTERMFKVSS--EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSDT
  . || . |.     .   .. |.. .| ... || |....     .|.|..|.   | ||  |. . | . |. . .| .    .   ||.|.|||  
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSIY
. ||| .| |   | . ....    ||. .|  ..|. . | . | .|    |
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_PTPRN_pd Subfamily PTPRN 50-290 3.1e-28 93.4 In-house 31-286 (297) alignment 
Range on Protein: 50-290
Range on HMM: 31-286/297.0
MAAQFGLLQQVTPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKEA-----NGYINASYLNGYR-EKRAFIIAQSPMENTARDFWKMIVDYKVSAIVM
.....  | .   .|.  .  .|.  ..||||.. || |. .| |||      . ||||| .      . |.| .|.|. .|  |||.|. .  |  ||.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LCGEED--CS--FPYWS--TLEKFGEYYVEV-TNEIKSNGYTERMFKV--SSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIhRQQKIGGGPVVV
|.  |.  ..    ||     | .. | |.. .. | .. |  | | .     .|.|.| |.    ||. |.  .....|.    |  .  .    |.||
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivv

HCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|||| . |.|||. . . |..  |    .|.    . .|  .|| | | .|.  .. 
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
0046846 (Phosphotyrosine protein) phosphatases II 99-296 5.7e-28 93.3 In-house 13-173 (176) alignment 
Range on Protein: 99-296
Range on HMM: 13-173/176.0
GYINASYLNGYRekraFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCS----FPYWSTLEKFGEyyvevtneiksngytermfkvssekesrsvl
 ||||... |.|    .|. | |...|  ||..|. .....|.|.|. | . .    . ||. |||.|                                
dyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............................

QLQVTDWPQDGIVREpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRRSKP-GAVTTLEQYTSIYDVID
| ....||  |.    . .|.... .  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| |||  .|... 
qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefel

MYL
..|
lll
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 98-289 1.5e-27 91.3 In-house 36-234 (239) alignment 
Range on Protein: 98-289
Range on HMM: 36-234/239.0
NGYINASYLNGYRE-KRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE----EDCSFPYWS-TLEKFGEYYVEVTNEIKSNGYTERMFKVSS--EKE
. |||||||  |    .|.| .|  .| .. |||.|. . .   |||| |     .   . ||  .  |. .  | . .      |  | | .|   . |
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqte

SRSVLQLQVTDWPQDGIVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
 | | | ..| ||. |. .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
eryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 98-289 1.5e-27 91.3 In-house 35-233 (239) alignment 
Range on Protein: 98-289
Range on HMM: 35-233/239.0
NGYINASYLNGYRE-KRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE----EDCSFPYWS-TLEKFGEYYVEVTNEIKSNGYTERMFKVSS--EKE
. |||||||  |    .|.| .|  .| .. |||.|. . .   |||| |     .   . ||  .  |. .  | . .      |  | | .|   . |
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqte

SRSVLQLQVTDWPQDGIVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
 | | | ..| ||. |. .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
eryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 106-292 1.6e-27 90.9 In-house 229-434 (440) alignment 
Range on Protein: 106-292
Range on HMM: 229-434/440.0
LNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED--CSFpYWSTL---EKFGEYYVEVTNEIKSNGYTERMFKVSSEKESRSVLQLQVTD
..||  | ||| .| |.. |  |||... ||..|.|.||   .|  ||  ||        || . |      . |    | ...   .|   . |..|  
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsi.ywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqt

WP----QDGIVREPR---TVLQVIDDV----IHR---QQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
||     ||.  . .   .|||..| .    | |   | . |   |..|||   .  |||.|.|   ||| . .| .||||  . .| |.|  | || .|
wptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdy

TSIYDVI
   | ..
llcykll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 73-292 1.8e-27 90.8 In-house 54-279 (290) alignment 
Range on Protein: 73-292
Range on HMM: 54-279/290.0
KAHASKNRSNEYLPPDKFIVALKEAN--GYINASYLNGYreKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC-----GEEDCSFPYWST---LEKFG
 ..  |||  .    ||  | ||.     |. | |..|   |  ||..| ....|. |.|.|... ||.||||||     |   |.  |  .      ||
ntefkknrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

EYYVEVTNEI-KSNGYTERMFKVSSEKESRS--VLQLQVTDWPQDGIVREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLeQCKAE
|. |  ..|  | .    ... |   .. ..  .  |..  ||.  .     ..|...  .  |.     ||||||||  . |.| . .. .|| |.  .
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qilld

G-VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|  .|. .. .|.|.|. ..|    ||  . ...
Gkeldlldlvralrnsrlnsvqvdiqylalveil
0049772 (Phosphotyrosine protein) phosphatases II 71-298 5.9e-26 87.3 In-house 42-282 (314) alignment 
Range on Protein: 71-298
Range on HMM: 42-282/314.0
SAKAHASKNRSNEYLPPDkFIVALK----EANGYINASYLNGYrekRAFIIAQSPMENTARDF----------WKMIV--DYKVSAIVM-----------
.  .. .|||. . || |   | |.    .  .||||||..|.   ..||..| |.|.|  ||          |.|..  |..|  |||           
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LCGEEDC-SFPYWSTLEKFGeyyvevtneiksngytermfKVS--SEKESRSVLQLQVTDWPQdG---IVREPRTVLQVIDDVihrqqkI
          |..     ..|  ..|| .                     ..    |. .| ....  ...|  |   . .  . .|..|...       
rLdaAlgKtpllildgngneptaadlellk....................eelydpelferlgikylripvpD.gsaplledfdeflefieea......d

GGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGVvDVFQVTKAVRRSKP-----GAVTTLEQYTSIYDVIDMYLQM
 ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .||||  |.... .||..
kggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
0049260 (Phosphotyrosine protein) phosphatases II 105-290 3.1e-25 84.1 In-house 1-144 (152) alignment 
Range on Protein: 105-290
Range on HMM: 1-144/152.0
YLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCSFP----YWstlekfgeyyvevtneiksngytermfkvssekesrsvlQLQVTD
...||. ...||..| |..||. |||.|. ......||||. ...  ..    |.                                       | . . 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.......................................qylhlp

WPQDGIVrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|| .|   .   .|. . ..|.. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .|.
wpDhgvp.dlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 62-296 1.1e-24 82.0 In-house 28-277 (307) alignment 
Range on Protein: 62-296
Range on HMM: 28-277/307.0
PDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALK---EANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE-----DCSfP
 .|. .  .. .| . ||| ..    ||  . .|    |  || | ||    . . || || |.|||  .|| |... || ...|||         |   
ktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikce.q

YWSTLEKFGEYYVEVTNEIKSNGYT-------ER-----MFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQkigggPVVVHCSDTVS
||   |     ..| .| |  .          |       .||   ..||.. .|| ..||. |. .   | . ... |   .      |||||||  | 
ywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvG

RSGVYCSVSIGLEQ-CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  .. |.  |.
rsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0051082 (Phosphotyrosine protein) phosphatases II 98-291 1.3e-24 81.9 In-house 3-148 (151) alignment 
Range on Protein: 98-291
Range on HMM: 3-148/151.0
NGYINASYLNGYrekraFIIAQSPMEntarDFWKMIVDYKVSAIVMLCGEEDCSfPYWSTLEKFGeyyvevtneiksngytermfkvssekesRSVLQLQ
..|||.||. |.     ... . |..    ||.... ......||.|..||     . . |.. |                            . ||...
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg............................ievlhip

VTDWPQDGIVREPRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
..|||  |.   . .||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
ildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
PTPc_DSPc_SM00012 193-292 1.5e-24 81.5 In-house 2-103 (105) alignment 
Range on Protein: 193-292
Range on HMM: 2-103/105.0
VLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
| ....|.||. |. .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...| . ||.||. |..|...||.|.|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 44-298 3.5e-23 76.5 In-house 22-287 (302) alignment 
Range on Protein: 44-298
Range on HMM: 22-287/302.0
KTRSTGMAAQFGLLQQVTPDPNDihCNSAKAHASKNRSNEYLPPDKFIVALK-EANGYINASYLNGYREKRAFIIAQSPMENTA---RDFWKMIVDYKVS
.  .. . ..|  ....  | .   |.. |.. .||.|...  .|. .| |. |.. |.||| ..    .|  |.|| |  ...    .||.|. . |. 
sldtaevkkefkkidtmkvdlek..CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

AIVMLCGEEDC------SFP-YWSTLEKFGEYYVEVTNEIKSNGYT-ERMFKVSSEKESRSVLQL--QVTDWPQDGIVREPRTVLQVIDDViHRQQKIGG
 .|.| |||..       ||    . ...|. .| .    |... . . .  |  |  | |||     .| |.|. .  .  .. . . .| . ..  . 
svvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikad

GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
 ..|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|.||.|.| .. .|.. 
entvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_ptpA1_pd Subfamily ptpA1 53-253 1.4e-21 71.7 In-house 26-253 (418) alignment 
Range on Protein: 53-253
Range on HMM: 26-253/418.0
QFGLLQQVTpDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALK-----EANGYINASYLNGYREKrAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE
.| ||..    |..      |  .||||  . || ..  | ||     | . |||| |..|   |  || .| |. ||  |||.|. . ..  ||||  |
efrlleesv.gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsre

-EDCSF---PYWS-------------TLEKFGEYYVEVTNEIKSN--GYTERMFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKIG
 |.|      ||                | || | ||. . |.        |  ... | |.| . | |   ||.  |    . . |..  .  ||..| 
sencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqii

-----GGPVVVHCSDTVSRSGVYCSVSIGL
       |..||||  | |.| .|.  | .
pssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 89-292 2.6e-21 70.5 In-house 57-265 (281) alignment 
Range on Protein: 89-292
Range on HMM: 57-265/281.0
KFIVALKEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG-----EEDCS--FPYWS-TLEKFGEYYVEVTNEIKSNGYTER
|. .  |..  || | |.     || .|..| | ..|  |||.|| . . .||||||       | |.  ||  .    .| .. |.  .    .     
kvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvtt

MFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIddvihRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRS-KPGA
 ...| | |.| . .    .||.  .      .|...     |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| . .  .
rlnlsyegetrlithwlwkewpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraas

VTTLEQYTSIYDVI
| ||.||  |. |.
vqtlqqymliwkvl
0044763 (Phosphotyrosine protein) phosphatases II 96-300 2.9e-21 71.4 In-house 16-175 (178) alignment 
Range on Protein: 96-300
Range on HMM: 16-175/178.0
EANGYINASYLNGYrekraFIIAQSPMentaRDFWKMIVDYKVSAIVMLCGEEDCS----FPYWSTLEKfgeyyvevtneiksngytermfkvssekesR
|.  |||||.  ..     ..... |.     |..... ......||.|..|  .     .||| . .                                
ersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..............................i

SVLQLQVTDWPQDGIVREPRTVLQVIDDVIhrqqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRRSKPgAVTTLEQYTSIYDV
 .|.. . |..   . .  . ... |....    .  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .|.  .|..
qylhipipDhgvpdllehflefvefieeal....dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyef

IDMYLQMNS
  ..|....
elrllkesd
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 101-285 5.5e-20 66.3 In-house 78-270 (301) alignment 
Range on Protein: 101-285
Range on HMM: 78-270/301.0
INASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE-----DC--SFPYWSTL-EKFGEYYVEVTN--EIKSNGYTERMFKVS---SE
| | ...   . . ||..|.|..||. ||| |.| |.|  ||||. .       |   .| . .   . | . ....|   | ..  ..| ..|     .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

KESRSVLQLQVTDWPQDGIVREPRTVLQVIDdVIHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
 ..|.|.  | ..|.. |. .    . .... .. . .|    |.|||||. . ||  . .  .   . .|.  ... .  | .|  .  .| | .| 
fatrtvthyqysewtdrgvPkshaelfdlme.lvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 97-299 9.2e-20 65.9 In-house 45-262 (290) alignment 
Range on Protein: 97-299
Range on HMM: 45-262/290.0
ANGYINASYLNgYREKRAFIIAQSPMENT-------ARDFWKMIVDYKVSAIVMLCGEE---------DCSFPYWSTLE---KFGEYYVEVTNEIKSNGY
...|| |...  . .  ..|. ||| |..         .|| |. . ||  .||||  |          |.  .  . .   ||.   |. .. .| .. 
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

TERMFKVSSEKES-RSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVRRSK
 .|   |  ..|    |   .. .| .  . ....|.|..|. |  ..      ||.||| | .||| .  .. .|       .| | . .| ||.|. .
etRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

PGAVTTLEQYTSIYDVIDMYLQMN
  |.|. .... .  .| ....  
alaitsalelafvdagivllaiev
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 87-298 3.6e-19 63.9 In-house 55-273 (288) alignment 
Range on Protein: 87-298
Range on HMM: 55-273/288.0
PDKFIVALK-EANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC-----GEEDC--SFPYWS-TLEKFGEYyveVTNEIKSNGY
 |   | |. ... ||.|  .   . || .| ||.|.. |   .|||...  |  |||||     | |     ||       ..| .    |   |..  
cditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl...ctvvkkkrad

TERMFKVSSEKESRS------VLQLQVTDWPQDGIVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAV
 ... |||  . |.       | .| . .|..||.  .  . |.... . .  ||    |.|||.|  | |.|    . | ||. . .  . . .. .  
idklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllakl

RRSKPGAVTTLEQYTSIYDVIDMYLQM
| ..  |..|  ||  .. ..  .| .
reerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 70-296 4.7e-18 59.8 In-house 50-289 (305) alignment 
Range on Protein: 70-296
Range on HMM: 50-289/305.0
NSAKAHASKNRSNEYLPPDKFIVALKEA--NGYINASYLNGY-REKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC-----GEEDCSfPYWSTL--E
.||.   .||| ..    |. .| |..     || | |.      .. || || |...|  .|| |... ||  |||||     |   |.  || .   |
qsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca.qywpaaqge

KF---GEYYVEVTNEIKSN----GYTERMFKVSS-EKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSI
|    .   ||     |           .....   ... || .|| |.||. |.     | |...  .  |  |.   |.|||||  . |.|   ..  
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaiey

GLEQCKA-EGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 ||.      .  . .. ||.|  .  .. .  ||  |. |.  |.
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_egg_pd Subfamily egg 92-296 9.1e-18 59.0 In-house 68-270 (307) alignment 
Range on Protein: 92-296
Range on HMM: 68-270/307.0
ValkeanGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED---CSFpYWSTLEKFGEYYVEVTNEI---KSNGYTERMFKVS
        .| | ...|      ||.||.|. ||  |||.|.   .|  ||||    .   | . ||   |.    .|  . .|   | .  .. .|.|.
d......dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkesercey.ywpkaesdslvtvpGslrienlkvdskadplfrvt

------SEKESRSVLQLQvTDWPQDGIVREPRTVLQVIddvihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV--DVFQVTKAVRRSKPG
      ...| | .   |  |. . . |  |  ||. .     |.      ||||.. . ||....  .. | | .     ..   | .  . .|. .. 
klklvGgddeerflehwq.gdvnnssdvysplrvlrkl.....rnl...skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrl

AVTTLEQYTSIYDVIDMYL
.| .  .|  .| .. ...
svesvllylfvyrlvlfff
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 111-291 2.5e-17 57.7 In-house 3-199 (199) alignment 
Range on Protein: 111-291
Range on HMM: 3-199/199.0
EKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED---CSFP-YWSTLE----KFGEYYVEVTNEIKSNGYTERMFKV----SSEKESRSVLQLQV
 .| .| .| |. .|  |||.|. .     |||.  ..    . .| ||.| |    |.|   | .        ||   . .    ..   .| . . | 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPQDGIVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
| | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 112-291 3.1e-17 57.4 In-house 3-198 (198) alignment 
Range on Protein: 112-291
Range on HMM: 3-198/198.0
KRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED---CSFP-YWSTLE----KFGEYYVEVTNEIKSNGYTERMFKV----SSEKESRSVLQLQVT
.| .| .| |. .|  |||.|. .     |||.  ..    . .| ||.| |    |.|   | .        ||   . .    ..   .| . . | |
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPQDGIVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 46-292 9.7e-16 52.2 In-house 25-286 (310) alignment 
Range on Protein: 46-292
Range on HMM: 25-286/310.0
RSTGMAAQFGLLQQvTPDPnDIHCNSAKAHASKNRSNEYLPPDKFIVALK----EANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAI
   |.. |.  |.    |.  .  .. | .  |||  . .  |.  | ||      . || | |..    . .|| .| |.. |  |||.|| . .  .|
gieglvkqyrklda.kqds.sltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesi

VMLCGEEDCS----FPYWSTLEKFGEY-YVEVTNEIKSNGYTER--------MFKVSSEKESRSVLQL--QV---TDWPQDGIVREprtVLQVIDDVIHR
..||   .        || .|     |  . |||  .|    |           .|  ...   . .|  ..    .||. |.  |     . . . .  
lllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde...kchtvpqrlla

QqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|  .  ||.|||||  . | .| ... . ... .    ||. .|   ...|.   . |  ||. |  | 
q..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 91-296 2.5e-15 51.2 In-house 51-270 (285) alignment 
Range on Protein: 91-296
Range on HMM: 51-270/285.0
IVALKE-ANGYINASYLNG-YREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC-----GEEDCSFPYWSTL---EKFGEYYVEVTnEIKSNGYT--
 | ||.    || ||..    ... ..| .| |. .|  |||.|| . |.. ..|||     | | |.. |   |    |||.| . .| | | .  .  
rvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlt.eckeeaiagt

--ERMFKVSSEKESRS---VLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRR
  . .  . .|  |     . ..||  ||..    . | ....   | . . |    |..||||  | |.  .  .     .   .  ...... . .| 
ilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremra

SKPGAVTTLEQYTSIYDVIDMYL
 .  || .  |.  .| |.  |.
mrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 90-302 2.7e-15 50.9 In-house 60-282 (312) alignment 
Range on Protein: 90-302
Range on HMM: 60-282/312.0
FIVALkEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE-----EDCSfPYWSTLEKFGE-----YYVEVTNEIKSNG---
| .|  . | || | ...       |...|.|.|||.  ||.. .    ..|..|||      | |.  | | .  | .      | |   ||.  |   
ftlag.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekca.kyisdivgfvdledhrvyteycteieiggksk

--YTERMFKVSSE---KESRsVLQLQVTDWPQDGIVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYC---SVSIGLEQCKAEGVVDVFQVt
   | |..||      .||. . . | . ||. |.     | |...  | ....|    ||. |||  | |.|  .   |.   | . . . | |.| . 
dkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl.

kaVRRSKPGAVTTLEQYTSIYDVIDMYLQMNSMY
  .|. .  .| .. ||     ..  .|  ...|
..lrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 64-301 3.1e-15 50.6 In-house 36-284 (303) alignment 
Range on Protein: 64-301
Range on HMM: 36-284/303.0
PNDIHCNSAKAHASKNRSNEYLPPDKFIVALKEAnGYINASYLNGYREKRAfIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE-------DCSFPYWS
| ..  |       |||  . .  |.  | | ..  || ||||.   .|.| |..| |.  || |||.||.. ||  ...|  .        |  ||   
ppsvsknqfvknmdknrfvdvicldhskvklsds.syihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq

TLEKFGEYYVEVTNEIK---SNGYTERMFKVSSEkESRSVLQL-QVTDWPQDGIVRE--PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVS
 . || | .. | .  .   ..|.. ..  ||   . .| |.. .  .||.. |  .  |. | |. .     ..   . | |      . |.| ..   
dflkfeersirvgefkrvelgdgwvlkvlsvsng.dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfe

IG-LEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNSM
   |   . .  .|. .. . ||  .  ||  | |.. .| ..  ..  | .
tahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngi
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 58-207 3.7e-15 50.2 In-house 79-236 (244) alignment 
Range on Protein: 58-207
Range on HMM: 79-236/244.0
QQVTPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKE---ANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG--EEDCSF
. . |||. ..       . |||    || |   | | .   .| |||||..        .|..| |. .|. |||||... .|  .|.|    |||  .
niirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeyw

PYWSTLEKFGEY-YVEVTNEIKSNGYTERMFKV-SSEKESRSVL-QLQVTDWPQDGIV
|    || . |   | .|.  .        ... |  .||   |  .|...|| ||  
pdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgtt
0048076 (Phosphotyrosine protein) phosphatases II 134-295 7.1e-15 50.4 In-house 26-142 (145) alignment 
Range on Protein: 134-295
Range on HMM: 26-142/145.0
VDYKVSAIVMLcgeedcsfpywstlekfgeyyvevtneiksngytermfKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQKigGGPVV
 |... ... |                                          | ..| ..|.. ..||  |.   ....|.... . . ...  ||||.
kdlgittvlnl......................................tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvl

VHCSDTVSRSGVYCsvsiGLEQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
||||  |.|.|...    ..  .. .| |..... . ||.  ||||.. .|.  .|... ..
VHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 118-288 1.2e-14 48.5 In-house 96-280 (302) alignment 
Range on Protein: 118-288
Range on HMM: 96-280/302.0
AQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCSFPYWSTL----EKFGEYYVEvTNEIKS--NGYTER----MFKVS------SEKESRSVLQLQ
   |  .|   .| .| .|.|. .| ||.    ||    .|.|.      |||.| |. | ..|   . .|..    ...|        .|  ..|  |.
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvk.tvsvktdleeftdkksfklytveiknekkkkkvkktvdila

VTDWPQDGIVREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
 . ||. |  .|. | |...      ...     |.||||  | |.|   ..  |.. |. . | |. .. . ||. . ||| . .| . .
fsawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
0048179 (Phosphotyrosine protein) phosphatases II 130-290 6.7e-14 47.3 In-house 22-139 (144) alignment 
Range on Protein: 130-290
Range on HMM: 22-139/144.0
WKMIVDYKVSAIVMLCGEEDCSFPYWStlekfgeyyvevtneiksngytermfkvssekesrsVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRQQkiGG
.... ........ |. | .  |.                                       ..|.. ..||  |.   .  .|.... . . ..   |
lellkklgittvinlteeyepeflere....................................giqylhlpwpDhgvpdllellleflefieeale..eg

GPVVVHCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|||.||||  |.|.|...        .| .| ...... . ||.  ||||.. .|.  ...
gpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 71-208 5.9e-13 43.3 In-house 27-181 (297) alignment 
Range on Protein: 71-208
Range on HMM: 27-181/297.0
SAKAHAS--KNRSNEYLPPDKFIVALKEA---NGYINASYLNGYREKR--AFIIAQSPMENTARDFWKMIVDYKVSAIVMLC----GEEDCSFPYWSTLE
|||  .|  ||| .. |  |.  | |. .   . |||| |.    |.    .|.|| |...|  |||.....  | .|||..    .  |  .|||   .
sakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

----KFGEYYVEVTNEIKSNgYTERM---FKVSSEKESRSVLQLQVTDWPQDGIVR
    | |.. ||   .   . .   .   ...   .||| |   |   ||. |.  
qerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvps
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-39 6.3e-13 43.5 In-house 265-303 (305) alignment 
Range on Protein: 1-39
Range on HMM: 265-303/305.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTVQKLK
||||||||||||||. | |.||.|.|  .|.   |.|||
mvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk
subfamily_CG42327_pd Subfamily CG42327 228-296 6.4e-13 43.1 In-house 246-315 (319) alignment 
Range on Protein: 228-296
Range on HMM: 246-315/319.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  ||.|||||| | |.|.  .  | ... .     ||. |.   ||| .  || | |||  || |. .| 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_PTPRK_pd Subfamily PTPRK 1-54 5.4e-12 40.1 In-house 259-312 (314) alignment 
Range on Protein: 1-54
Range on HMM: 259-312/314.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTVQKLKAINPKTRSTGMAAQF
||.| .||.|..|..||| .|||| ||. .. ..  . . ..|.| |. .  .|
mveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeef
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 34-186 7.2e-12 39.7 In-house 8-180 (350) alignment 
Range on Protein: 34-186
Range on HMM: 8-180/350.0
TVQKLKAINPKTrsTGMAAQFGLLQQVTPDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALK-------------EANGYINASYLNGY----REKRAF-
  .||| | .|   . . ... |  . . . ||.   .     .||| .. || ..  | ||             ..| ||||.||.      . .  | 
krsklkliitkn..stvksrlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfk

-IIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCS----FPYWSTLEkFGEYYVEVTNEIKSNGYTERMFKVSS
 | .|.|. .|  ||.|.|.  ||  |..|  . .        ||  .. . .. | ...  .. . .. . . |.
YiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs.ydditvklaskwenimgindsslysa
subfamily_eak_pd Subfamily eak 93-202 1.3e-11 38.5 In-house 73-190 (332) alignment 
Range on Protein: 93-202
Range on HMM: 73-190/332.0
ALKEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE-------EDCSFPYWS-TLEKFGEYYVEVTNEIKSNGYTERMFKV
. .. .|||||| ..     | .|..  . |.    ||.|... |  |||.|  .        |  ||  .    ||| . ||  . .| | .  |....
sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllel

SSEKESRSVLQLQVTDWP
|   |.  ||  .|  | 
skGnethrvlhykvfGwt
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 96-206 1.4e-11 38.8 In-house 11-126 (130) alignment 
Range on Protein: 96-206
Range on HMM: 11-126/130.0
EANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCSfPYWSTLEKFG--EYYVEVTNE--IKSNGYTERMFKVSSEK-ES
. | |||||..      . .. .| |. .|. |||||...  |  .|.|   |.    ||   | .   |  . ||     ...      ....|.  ||
qgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.eywpdsePlewyeediivtltdrdefknikasnleiesdlnes

-RSVLQLQVTDWPQDGI
 ...  .|...|| || 
hqaltmfqisnwpsdgt
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 49-148 1.8e-11 38.3 In-house 23-123 (305) alignment 
Range on Protein: 49-148
Range on HMM: 23-123/305.0
GMAAQFGLLQQVTpDPNDIHCNSAKAHASKNRSNEYLPPDKFIVALKEA--NGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG
|. |.|  ....  | . ...     .| |||  .    |.  | |. .    || | |.    . . || .|.|.|.|  ||| | .. || || ||| 
glraefvamkrfn.dfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcn

EE
  
ll
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-55 3.7e-11 37.6 In-house 262-316 (318) alignment 
Range on Protein: 1-55
Range on HMM: 262-316/318.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTVQKLKAINPKTRSTGMAAQFG
|||| |||.|..|..|||...|.||. ...  | ...|.  .|..  | | |.| 
mvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq
subfamily_CG42327_pd Subfamily CG42327 95-217 1.6e-10 35.1 In-house 53-187 (319) alignment 
Range on Protein: 95-217
Range on HMM: 53-187/319.0
KEANGYINASYLNGYREKRA-FIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCS----FPYWSTLE------KFGEYYVEVTNEIKSNGYTER--M
.. . |..|||. ||.. .. .| || ..|... |||... . .   || |.   .        |. | |       .|.. | . .    . |     .
ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistll

FKVSSEKESRSVLQLQVtDWPQDGIVREPRTVLQVI
.|   ..||| .      .|.. ..  |..... ..
lkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 70-144 4e-10 33.8 In-house 41-116 (347) alignment 
Range on Protein: 70-144
Range on HMM: 41-116/347.0
NSAKAHASKNRSNEYLPPDKFIV-ALKEANGYINASYLNGYREKRAFIIAQSPMENTARDFWKMIVDYKVSAIVML
| .| .  .. .   | |.|       ....|||||...    .. .|..| |. .| ||||||.   ||. .| .
nrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-54 1.9e-09 31.9 In-house 261-314 (315) alignment 
Range on Protein: 1-54
Range on HMM: 261-314/315.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTVQKLKAINPKTRSTGMAAQF
|||...|| |..||.||...||.| |  . |.   . | | .| | || .  ||
mvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllapspdtgstllqeqf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-54 5.5e-09 30.5 In-house 265-318 (319) alignment 
Range on Protein: 1-54
Range on HMM: 265-318/319.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTVQKLKAINPKTRSTGMAAQF
|||. .|| |...|.|||. .|.|||  ..    ...|.  ...|  ||.. .|
mvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-93 8.2e-09 29.1 In-house 258-352 (515) alignment 
Range on Protein: 1-93
Range on HMM: 258-352/515.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTVQKLKAINPKTRSTGMAAQFGLLQQVTPDPNDIHCNSAKA--HASKNRSNEYLPPDKFIVA
.||| .|| |...|||| .   .| ||   .   .| |..       . |. .|  |. ..|||   .. |...     |||  . || ..  | 
lvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvi
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 125-305 1.5e-08 29.0 In-house 40-231 (255) alignment 
Range on Protein: 125-305
Range on HMM: 40-231/255.0
TARDFWKMIVDYKVSAIVMLCG-----EEDCS--FPYW-STLEKFGEYYVEVTNEIKSNGY-TERMF-KVSSEKESRSVLQLQVTDWPQDGIVREPRTVL
|   |...||  | . .||||       |.||  ||       |. .  | .|. .      | ..  ...  |. . |   . . |..    ...| .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

QVIDDVihRQQKigggPVVVHCSDTVSRSGVYCSVSI-------GLEQCKAeGVVDVFQVTKAVRRSKPGAVTTLEQ-YTSIYDVIDMYLQMNSMYGNF
...  |  |. |    .||||||  . ||  .  . .        |.. .. . .|  .. . .| ....|. |  |   ||. |.|..   . .  ..
nilkvv..rdsk....svvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleaky
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 231-292 1.5e-08 28.9 In-house 230-291 (297) alignment 
Range on Protein: 231-292
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||||.. .||..
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 188-301 1.9e-08 28.4 In-house 183-292 (305) alignment 
Range on Protein: 188-301
Range on HMM: 183-292/305.0
KESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV-DVFQVTKAVRRSKPGAVTTLEQYT
...| | .    |||. |.     ..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  .. . .|  .  .. | .|| 
ekarkvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqyl

SIYDVIDMYLQMNSM
 ...||  |.. . .
fvhqvilnyfrkkkl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 96-157 3.4e-08 27.2 In-house 88-151 (349) alignment 
Range on Protein: 96-157
Range on HMM: 88-151/349.0
EANGYINASYLNGY--REKRAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCSFPYWST
  . |||| ||.      .. .|  | |.  |  ||.|.|.  .|  .. |  ... |.  .  
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdi
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 233-292 3.8e-08 27.6 In-house 2-61 (69) alignment 
Range on Protein: 233-292
Range on HMM: 2-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_hpo-7_pd Subfamily hpo-7 124-299 6e-08 26.9 In-house 45-231 (263) alignment 
Range on Protein: 124-299
Range on HMM: 45-231/263.0
NTARDFWKMIVDYKVSAIVMLC-----GEEDCSF--PYW-STLEKFGEYYVEVTNEIKSN-GYTERMFK-VSSEKESRSVLQLQVTDWPQDGIVREPRTV
.|   |...||  | . .||||     | |.||   |       |. .  | .|. ..     |. . . ..  |. . | . . . |..   ....| .
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LQVIDdvIHRQQKigggPVVVHCSDTVSRSGVYCSVSIG-------LEQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQY-TSIYDVIDMYLQMN
|....  . |. |    ..|||||  . ||  .  . .        |.. .  . .|  .. . .| |...|. |  |   ||. |.|. |. .
lnilk..varnsk....slvvhcstGiGrsaafsvaElvyqkmirsldtts.tveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnf
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 233-293 1.4e-07 25.8 In-house 1-61 (69) alignment 
Range on Protein: 233-293
Range on HMM: 1-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| . 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1-54 1.6e-07 25.0 In-house 176-229 (440) alignment 
Range on Protein: 1-54
Range on HMM: 176-229/440.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTVQKLKAINPKTRSTGMAAQF
|||| .||.|.|.||||...||.| |  ..    |....  ||.|  . .  .|
mvqtpeqyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqef
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 98-144 1.8e-07 24.9 In-house 60-107 (332) alignment 
Range on Protein: 98-144
Range on HMM: 60-107/332.0
NGYINASYLNGYREKRAFIIAQSPMEN-TARDFWKMIVDYKVSAIVML
. . |||...|| .| |.|.||.|... |   ||.|. . | | |...
ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 105-297 2e-07 24.0 In-house 107-310 (346) alignment 
Range on Protein: 105-297
Range on HMM: 107-310/346.0
YLNGYREKRAFIIAQSP-MENT--ARDFWKMIVDYKVSAIVMLCGEEDCSFPYWSTLEK-------FGEYYVEVTNEIKSNGYTERMFKVSSEKESRSVL
|.  .. .. .|.|| | |||     ||| || . ..  . ..  ..       | ..         |  ...      |    |   .|  | .| ||.
yfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvi

QLQVTDWPQDGIVREPRT--VLQVIDDVIHRQQKIGGGPVVVhCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
       |   . . |.|  ....| .    .|    |  ||       |.  .      ..|       ..... |.... .||.| .. ||.||| ..
cqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaiv

DMYLQ
  |. 
fdyia
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 192-254 3.2e-07 24.4 In-house 216-287 (350) alignment 
Range on Protein: 192-254
Range on HMM: 216-287/350.0
SVLQLQVTDWPQDGIVREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLE
 |.||||  |.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....   |.
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDslls
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-54 4.1e-07 24.4 In-house 270-323 (325) alignment 
Range on Protein: 1-54
Range on HMM: 270-323/325.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTVQKLKAINPKTRSTGMAAQF
||.| |||.....|. ||...|.|..|  .. . .  |.  || |.   .  .|
mvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqklniekef
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1-35 5.5e-07 23.8 In-house 248-282 (283) alignment 
Range on Protein: 1-35
Range on HMM: 248-282/283.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTV
.||||||| ..|..|||  .||.|.|   . .||.
avqtldqyklvhelvleqalcgdtqiaavdlqsti
PTPc_motif_SM00404 165-265 5.5e-07 24.6 In-house 31-117 (140) alignment 
Range on Protein: 165-265
Range on HMM: 31-117/140.0
YVEVTNEIKSNgytermfkvsSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVihrqqKIGGGPVVVHCSDTVSRSGVYCSV-SIGLEQCKAEGVVD
 ..||.|.. .          .|.... .||... |  .| .... . ||..|...     .  || |.|||   ||||.  . .  .  .|.... ...
vinvteevslt..........kensgfqilqiplddnekdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeaye

VF
..
fv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 190-254 1.5e-06 21.8 In-house 217-290 (349) alignment 
Range on Protein: 190-254
Range on HMM: 217-290/349.0
SRSVLQLQVTDWPQDGIVREPRTVLQV-------IDDVIHRQ--QKIGGGPVVVHCSDTVSRSGVYCSVSIGLE
   .||||| .|.  ... .| ..||        |||   |.  ..    ...||||    |.||.. . . |.
PyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
subfamily_DSP12_pd Subfamily DSP12 180-247 5e-06 21.0 In-house 38-100 (155) alignment 
Range on Protein: 180-247
Range on HMM: 38-100/155.0
RMFKVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVIHRqqkigGGPVVVHCSDTVSRSGVYC
.... . .|   | ...|..| |.  |..   .... |.. ...     .| |.|||   ||||   .
elpehklkkgkvstkfiqilDepeediLshldeavdFieealee.....egavlvHCqagvSRSvtiv
subfamily_DSP1_pd Subfamily DSP1 195-286 5.4e-06 20.6 In-house 66-153 (163) alignment 
Range on Protein: 195-286
Range on HMM: 66-153/163.0
QLQVTDWPQDGIVREPRTVLQVIDDVIHRqqkigGGPVVVHCSDTVSRSGVYCSVSI-GLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYT
.|.. | |.. |    ..|.. ||.|..      .| | .||   .|||   | . .   .... |   |  .  ... .   | |  | .| 
klkleDspkadislvfeeviefidevkkk.....nGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnye
subfamily_PTPRG_pd Subfamily PTPRG 1-40 5.7e-06 19.8 In-house 269-304 (563) alignment 
Range on Protein: 1-40
Range on HMM: 269-304/563.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENymstVQKLKA
.||| .||.|||||.||||  .|||. .|.    |..|| 
lvqteEqYiflhdalleaiasketellaeq....veelkn
subfamily_PTPRA_pd Subfamily PTPRA 1-53 6.6e-06 20.2 In-house 277-329 (330) alignment 
Range on Protein: 1-53
Range on HMM: 277-329/330.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTVQKLKAINPKTRSTGMAAQ
||||. ||.|.. ..||  . |.||.      . .|||..  ..|  .|.  .
mvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkigleee
DSPc Dual specificity phosphatase, catalytic domain 166-246 8.3e-06 20.7 Pfam-A 23-90 (133) alignment 
Range on Protein: 166-246
Range on HMM: 23-90/133.0
VEVTNEIKSNgytermfkVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVihrqqKIGGGPVVVHCSDTVSRSGVY
..||.|.. |         ...|...  |...| |  .. |..| . . ..|...     .  |. |.|||   .|||.  
invtkevpnn........naikkseieylripvedetetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSatl
DSPc Dual specificity phosphatase, catalytic domain 166-246 8.3e-06 20.7 In-house 23-90 (133) alignment 
Range on Protein: 166-246
Range on HMM: 23-90/133.0
VEVTNEIKSNgytermfkVSSEKESRSVLQLQVTDWPQDGIVREPRTVLQVIDDVihrqqKIGGGPVVVHCSDTVSRSGVY
..||.|.. |         ...|...  |...| |  .. |..| . . ..|...     .  |. |.|||   .|||.  
invtkevpnn........naikkseieylripvedetetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSatl
0040438 (Phosphotyrosine protein) phosphatases II 1-51 9.8e-06 20.5 In-house 258-308 (317) alignment 
Range on Protein: 1-51
Range on HMM: 258-308/317.0
MVQTLDQYVFLHDAVLEAIICGETEIPTENYMSTVQKLKAINPKTRSTGMA
.|||..||.||.||.|| . ...| .|  .... ..||... . ...... 
avqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklke