Gene PTPRD-54 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP111_AA protein Get Run
AqueP111_AA_818-957 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 809-958 2.6e-73 241.4 In-house 3-152 (301) alignment 
Range on Protein: 809-958
Range on HMM: 3-152/301.0
DELGTHVATCHSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFW
..||||||..|||.|.|||..|..| ||.|..|..|||.|.||||||||||||||||.|...||.|||||||||||||||...||||.||||||||||||
edlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfW

RLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNEQ
|||||||||||||||||||||||||||||||..|||..|| |||||.|||
rliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 805-958 1e-51 170.9 In-house 3-156 (305) alignment 
Range on Protein: 805-958
Range on HMM: 3-156/305.0
PVSVDELGTHV---ATCHSNGFDEQYESLYTGiDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMK
....|.| ...    . ...|...||.|||.  .. . .| .|.|.| ||.|.||..||.||||... .||  ...||||||.|||....|.|..|||.|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNEQ
.|..||||||..||...|||.|.|.|| |.||.||||.  .|. .||.|.|.|..|.
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksek
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 806-958 1.2e-47 157.2 In-house 2-156 (290) alignment 
Range on Protein: 806-958
Range on HMM: 2-156/290.0
VSVDELGTHVATCHS---NGFDEQYESLYTGI-DKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQREYINASYIDGYSSSNKFIASQGPMK
. ||..| .||. |.   .|| .|...| .|  ..   .|  ..|   |||.|| |||||||.| |  .   |. |||||.||.||. ....|| |||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraES-DhFGSFTVTLTNEQ
.||||||.||||||   |||.|| .|  | || ||||.   .. . .| |...|.||.
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtka.ygefsikllnee
subfamily_PTPRD_pd Subfamily PTPRD 805-957 1.4e-46 154.3 In-house 4-155 (564) alignment 
Range on Protein: 805-957
Range on HMM: 4-155/564.0
PVSVDELGTHVATCHSN---GFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmCQREYINASYIDGYSSSNKFIASQGPMK
|..|.|| .|||  ..|    |.|.|... .|   ..    ...| | ||..||. || .|..| . ..    . .|||||.|||| .....||.|||..
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPla

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaeSDHFGSFTVTLTNE
.|. ||||..|...  .|||.|.|.| .| ||..|||. .  . ..|..||||..|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg..tetygeltVtleee
subfamily_PTPRG_pd Subfamily PTPRG 806-957 5.5e-41 135.4 In-house 1-155 (563) alignment 
Range on Protein: 806-957
Range on HMM: 1-155/563.0
VSVDELGTHVATCHSNG---FDEQYESLYTGIDKR---CIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQrEYINASYIDGYSSSNKFIASQGP
| |.|.  ||| .|..|   |.|..|.| . . ..   .    ..||   ||  ||. ||  |. |.|    .    .||||.|||||  |..|||.|||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

MKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
.|.|. ||||.||...   |||.|||.| .. ||..|||.   || ..|...|||..|
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtliee
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 806-958 1.4e-40 134.1 In-house 2-151 (287) alignment 
Range on Protein: 806-958
Range on HMM: 2-151/287.0
VSVDELGTHVATCHS---NGFDEQYESLYT--GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILApnrkldMCQREYINASYIDGYSSSNKFIASQGPM
..|...|  ||. |    .|| .|.  |      ..   ..  ..|   ||...| |.|..|..|        .. .||||..||||.....||....||
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPm

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAesDHFGSFTVTLTNEQ
 .|...||.||.....  |||....|| ....| ||||....    .| ....|.||.
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee
0051299 (Phosphotyrosine protein) phosphatases II 821-957 6.8e-40 132.7 In-house 23-156 (288) alignment 
Range on Protein: 821-957
Range on HMM: 23-156/288.0
NGFDEQYESLYTGI-DKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSI
.|. |..| |.  . |  . ... .||   ||...|  ||..|..| .  .  .    |||||||||| ...|||| |||...|. ||||..|...   |
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvI

VMVTNLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
||.|.| |  . ||.||||.   .|  .| .||||..|
vmltklvelgrekcaqYwpl..ggsltygditvtllse
subfamily_PTPRB_pd Subfamily PTPRB 805-958 1.4e-39 130.9 In-house 6-160 (293) alignment 
Range on Protein: 805-958
Range on HMM: 6-160/293.0
PVSVDELGTHVATCHS---NGFDEQYESLY-TGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPM
|...... .||.. ..    .| |.||.|   | |. . .  ...|.| ||..||  || .|. ||. .  |  . .||||.||.||.| ..|||.|||.
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyipgynsprefiatqGPl

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESdHFGSFTVTLTNEQ
 .|. ||||..|..|   |||.|.| |. | |||.|||. . .   .|. .|||..|.
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaee
subfamily_PTPRA_pd Subfamily PTPRA 805-956 1.9e-39 130.5 In-house 13-164 (330) alignment 
Range on Protein: 805-956
Range on HMM: 13-164/330.0
PVSVDELGTHVAT---CHSNGFDEQYESLYT-GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPM
|. |..|   .       .. | |....| .  |.  . .  .|||   ||. ||  || .|.||.. .  .  . .|||||.||||   .||||.||| 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaqGPk

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaeSDHFGSFTVTLTN
..|. ||||.||. |  .|||.|.|||  ..||.||||.    .  .|  .|.. .
eetvedfwrmiweqksativmltelkerkeekcaqywPdeG..lvtyGnirveved
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 813-957 1.9e-39 130.4 In-house 13-155 (288) alignment 
Range on Protein: 813-957
Range on HMM: 13-155/288.0
THVATCHSNGFDEQYESL-YTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLI
..      .|| |.|.||   . .|   .| . .|   ||..||  || .|. |      .  . .|||||||||. ...|.||.|||. .|. |||.|.
akksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkle..eeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaESDHFGSFTVTLTNE
...|   |||.|.| || |.|||.|||..  .  ..||.||||...
yenktstivmltelveggktkCeeYWPdad.kpknyGsvtvtlves
0040438 (Phosphotyrosine protein) phosphatases II 821-957 2e-39 131.1 In-house 18-150 (317) alignment 
Range on Protein: 821-957
Range on HMM: 18-150/317.0
NGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
... |..| |.. .   . ... .||  .||...|  ||..|..| |  .       ||||||.||.. ..|||| |||...|. ||||..|...  .||
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MVTNLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
|.|.|.|  . ||.||||.   |. ..| |||||..|
mLteleelgrekcaqYwpl..getltygdftvtllse
0050432 (Phosphotyrosine protein) phosphatases II 822-957 2.9e-39 130.6 In-house 43-175 (308) alignment 
Range on Protein: 822-957
Range on HMM: 43-175/308.0
GFDEQYESLYTGID-KRCIIGYNEENTAFNRFKNITVYDDNRIILapnrklDmCQREYINASYIDGY--SSSNKFIASQGPMKKTLVDFWRLIWQEKPVS
...|..| |.   .   . ... .||  .||.|.|  || .|..|      |     ||||||.|||   ...|||| |||...|. ||||..|...   
lleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVMVTNLKEGTKSKCEQYWPNGRA-ESDHFGSFTVTLTNE
|||.|.| |  . ||.||||.    .| ..| |||||..|
IvmLtklvengrekcaqYwplelgggsleygkftvtllse
0036941 (Phosphotyrosine protein) phosphatases II 835-957 1.3e-38 128.4 In-house 28-144 (297) alignment 
Range on Protein: 835-957
Range on HMM: 28-144/297.0
DKRCIIGYNEENTAFNRFKNITVYDDNRIILapnrklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCE
.  . .. ..||   ||.|.|  ||..|..|      |     ||||||.|||. ..|||| |||...|. ||||..|...  .|||.|.| |  . ||.
lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

QYWPNGRAESDHFGSFTVTLTNE
||||.   ||  .| |||||...
qywpleegesltygdftvtllsv
0046845 (Phosphotyrosine protein) phosphatases II 823-957 1.8e-38 128.0 In-house 2-142 (284) alignment 
Range on Protein: 823-957
Range on HMM: 2-142/284.0
FDEQYESLYTGIDK---RCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKlDMCQREYINASYIDGY-----SSSNKFIASQGPMKKTLVDFWRLIWQE
..|..| |.    |    . ... .||   ||.|.| .||..|..| .  . |.   .||||||.|||      ...|||| |||...|. ||||..|..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPVSIVMVTNLKEGTKSKCEQYWPNGrAESDHFGSFTVTLTNE
.   |||.|.| |  . ||.||||.   |. ..| |||||..|
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllse
0039614 (Phosphotyrosine protein) phosphatases II 819-957 6.2e-38 126.3 In-house 30-163 (297) alignment 
Range on Protein: 819-957
Range on HMM: 30-163/297.0
HSNGFDEQYESLYTGIDKrCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMcQREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPV
 ........|.|.  ..  . |.. .||  .||.|.|  ||..|..| |... |.    ||||||.|||.  ..||||.|||...|. ||||..|...  
sktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvt

SIVMVTNLKEGTKsKCEQYWPNGRAesdHFGSFTVTLTNE
.|||.|.|.|  . ||.||||.       .| |||||...
vivmLtklvelgr.kcaqywpeegg...tygdftvtllkv
subfamily_Ptp69D_pd Subfamily Ptp69D 808-957 6.6e-38 125.5 In-house 6-155 (307) alignment 
Range on Protein: 808-957
Range on HMM: 6-155/307.0
VDELGTHVATCHS---NGFDEQYESLY-TGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKT
.|.| . . . .     |. . ||.|  . ||| . .. ..||.  ||...|. .|..|..|..    .  . .|||||.| ||  ..||||.|.|.  |
iddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveat

LVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraESDHFGSFTVTLTNE
. ||||.|.. .   |||..||.| .. ||..|||.   .  ..|.  |.| .|
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvse
0047943 (Phosphotyrosine protein) phosphatases II 830-957 1.7e-37 124.8 In-house 21-144 (273) alignment 
Range on Protein: 830-957
Range on HMM: 21-144/273.0
LYTGI-DKRCIIGYNEENTAFNRFKNITVYDDNRIILapnrklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEG
|.  . .  . ... .||  .||.|.|  ||..|..|      ..    ||||||.||| ...|||| |||...|. ||||..|...   |||.|.| | 
llslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvel

TKSKCEQYWPNGRAE-SDHFGSFTVTLTNE
 . ||.||||.   | |  .| |||||..|
grekcaqYwpleggelsltygkftvtllse
DSPc_SM00195 823-957 1.8e-37 124.5 In-house 2-135 (263) alignment 
Range on Protein: 823-957
Range on HMM: 2-135/263.0
FDEQYESLYTG-IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
..|..|.| .   .|..  .  ..|.. ||.||| .||..|..| .. |    . .||||.||.|.....|.|| |||...|. ||||..|.||   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNE
.|. .|  | ||..|||.   ..  ||...|.|...
lteeeengkekcdrywpeesggketfgkisvklvev
PTPc_SM00194 823-957 1.8e-37 124.5 In-house 2-135 (263) alignment 
Range on Protein: 823-957
Range on HMM: 2-135/263.0
FDEQYESLYTG-IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
..|..|.| .   .|..  .  ..|.. ||.||| .||..|..| .. |    . .||||.||.|.....|.|| |||...|. ||||..|.||   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNE
.|. .|  | ||..|||.   ..  ||...|.|...
lteeeengkekcdrywpeesggketfgkisvklvev
0043336 (Phosphotyrosine protein) phosphatases II 819-957 3.6e-37 123.7 In-house 18-151 (278) alignment 
Range on Protein: 819-957
Range on HMM: 18-151/278.0
HSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVS
   .. ...|.|..     . |.. .||  .||.|.|  || .|..| .  .       ||||||.|||. ..||||.|||...|. ||||..|...  .
lktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMVTNLKEGTKSKCEQYWPngrAESDHFGSFTVTLTNE
|||.|.|.|  . || ||||    .|  .| |||||..|
ivmLtelvelgrvkcaqYwp...ggsltygdftvtllke
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 806-957 3.9e-37 123.0 In-house 2-153 (318) alignment 
Range on Protein: 806-957
Range on HMM: 2-153/318.0
VSVDELGTHVATCHSNG---FDEQYESLYTGIDKRCI-IGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMK
.||..| .||.  ...|   ..|.|| |    ..       .. | | ||. ||. ||. |. | .    .  . .||||.||||| .....||.|.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmle..geegsDyinanyidGyrrkkayiaaqaPlp

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
.|. ||||..|. .   |||.|...| .| |...|||.   .| ..|. .|.|..|
etieDfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkee
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 819-957 5.7e-37 122.4 In-house 13-149 (281) alignment 
Range on Protein: 819-957
Range on HMM: 13-149/281.0
HSNGFDEQYESLYT-GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPV
...|| |.||.|.  |.|.     ...||.  ||..||. ||  |. ..|| .  ..  .||||....||.. ...||.|||. ..||.||...|..|  
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenknt..DYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

SIVMVTNLKEGTKSKCEQYWPNGRAeSDHFGSFTVTLTNE
 |||||.  |. | || .|||.... . ..| .||. |.|
aivmvtreieagklkChrYWPddns.elkygdvtvkstae
subfamily_PTPRK_pd Subfamily PTPRK 815-955 1.5e-36 120.9 In-house 16-147 (314) alignment 
Range on Protein: 815-955
Range on HMM: 16-147/314.0
VATCHSNGFDEQYESLYTGIDKrciiGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQE
. .... || |.||||. | |       ..|| . ||...|  ||  |..| .    .  . .||||..||.|  ...||. |||...|. |||||...|
lkraegygfkeeyeslfegwda....akkdenreknrsgdilaydrsrvflitid..gdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvyde

KPVSIVMVTNLKEGTKSKCEQYWPNgraESDHFGSFTVTLT
.  ||||.|.|.| .. || .|||.   .....| . |.| 
ncasivmltelvevgrvkClkyWPe...dtevygdikvelv
0045450 (Phosphotyrosine protein) phosphatases II 821-957 1.1e-35 119.3 In-house 27-172 (307) alignment 
Range on Protein: 821-957
Range on HMM: 27-172/307.0
NGFDEQYESLYTGIDK---RCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdMCQREYINASYI--------DGYSSSNKFIASQGPMKKTLVDFWR
.|. ...|.|.   ..    . |.. .||  .||.|.|  ||..|..| .  .  .    ||||||.        ||| ...|||| |||...|. ||||
tgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

LIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGrAESDHFGSFTVTLTNE
..|...   |||.|.|.| .. || ||||.   |.  .| |||||..|
mlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllse
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 817-957 1.5e-35 117.9 In-house 23-163 (298) alignment 
Range on Protein: 817-957
Range on HMM: 23-163/298.0
TCHSNGFDEQYESLYTGID----KRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIW
. .  |...... | .. .    .   .. ..||   ||. .|  .|  |..|  .   .  . .|||||....|. .| |||.|.|...|..||||...
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

QEKPVSIVMVTNLKEGTKSKCEQYWPNGRaeSDHFGSFTVTLTNE
.|.  .|||.|||.|  | |...|||. .  ....|..||.| ..
eedigtiVmltnleeldktkyhkywPdeg..ketygeitvsllsk
subfamily_PTPN6_pd Subfamily PTPN6 806-958 2.4e-35 117.0 In-house 11-164 (306) alignment 
Range on Protein: 806-958
Range on HMM: 11-164/306.0
VSVDELGTHVATCHSNGFDEQYESLYTGID---KRCIIGYNEENTAFNRFKNITVYDDNRIILApnrKLDMCQREYINASYIDG--YSSSNKFIASQGPM
  |.||  .  . . .|| |..|.| .           |   ||.  ||.|||  .|..|.||.   . .. . .||||.||..   .|....||.|| .
qrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgcl

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDhFGSFTVTLTNEQ
..|. ||||..|||.   |||.|.  | .|.|| .|||.  .... .|. .|| ..|.
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek
0045098 (Phosphotyrosine protein) phosphatases II 824-957 4.3e-35 116.8 In-house 11-128 (278) alignment 
Range on Protein: 824-957
Range on HMM: 11-128/278.0
DEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIIlapnrkldmcqrEYINASYIDGYssSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVT
 | .. | .||  ..  .  ..| ..||.|.|  || .|..            .||||||||||  ..|||| |||...|. ||||..|...  .|||.|
lefefllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlt

NLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
.|.|... ||.||||.   .|  .| |||||..|
elvelgrekcaqywpe..ggsltygdftvtllse
Y_phosphatase Protein-tyrosine phosphatase 847-956 5.1e-35 116.4 Pfam-A 2-108 (235) alignment 
Range on Protein: 847-956
Range on HMM: 2-108/235.0
TAFNRFKNITVYDDNRIILapnrkL------DmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG
   ||.|.|..||..|. |            |     ||||.|..||....||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||. 
kkknRykdilpydktrvkl.....kgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

RAESDHFGSFTVTLT-N
. || ..|...|.|. .
eeesltygdikvelkek
Y_phosphatase Protein-tyrosine phosphatase 847-956 5.1e-35 116.4 In-house 2-108 (235) alignment 
Range on Protein: 847-956
Range on HMM: 2-108/235.0
TAFNRFKNITVYDDNRIILapnrkL------DmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG
   ||.|.|..||..|. |            |     ||||.|..||....||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||. 
kkknRykdilpydktrvkl.....kgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

RAESDHFGSFTVTLT-N
. || ..|...|.|. .
eeesltygdikvelkek
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 805-957 7.2e-35 115.5 In-house 4-155 (319) alignment 
Range on Protein: 805-957
Range on HMM: 4-155/319.0
PVSVDELGTHVATCHSNG---FDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSSNKFIASQGPMK
.. |.|| ... . .|.|   ...... | .. ..      .|||   ||..||  ||  |..|..     . . .|||||.||||   .|||| |.|..
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqaPle

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAEsdHFGSFTVTLTNE
.|. ||||..|.|.   .||.|.|.|  | |...|||.   |  ..| ..||| .|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfe..eyGrlivtleee
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 825-957 7.3e-35 115.2 In-house 13-139 (283) alignment 
Range on Protein: 825-957
Range on HMM: 13-139/283.0
EQYESLyTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldmcqrEYINASYID---GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
|... | .  |. . |  ..||  .||...| ..| .|. | .. .      .||||..|     |  ..|.|..|.|...| ||||.....|| ..|||
evlkrl.svpdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm

VTNLKEGTKSKCEQYWPNgrAESDHFGSFTVTLTNE
.|.|.|. . || ||||.    |  .| ||||| .|
ltklqedlrikCsqyWPk..rGsedyGeftvtlrke
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 805-957 1.3e-34 114.6 In-house 5-155 (315) alignment 
Range on Protein: 805-957
Range on HMM: 5-155/315.0
PVSVDELGTHVAT---CHSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILaPNRKLDmCQREYINASYIDGYSSSNKFIASQGPMK
|. .|.| |.||       ||| ..|||.  |  .   .  . ||   ||. ||  ||  |. | |  . |  . .|.||..||||.  ...||.|||  
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvql.pllend.phsdyvnanfidGynkkrryiaaqgpnv

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraeSDHFGSFTVTLTNE
 .. |||||...|.   |||.||| || |.|.|.|||.       .| .|||. .|
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkse
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 819-955 2.3e-34 113.7 In-house 17-151 (315) alignment 
Range on Protein: 819-955
Range on HMM: 17-151/315.0
HSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPnrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVS
|.  | |..  |      |  .. ...|   ||.|||  .| .|..|      |  ...||||||| .. . . .|||||| | .. ||||...|||. .
htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklev..iddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtt

IVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLT
|||||...|| | || ||||. .|.| .|||. |.| 
ivmvtkkqegdkikcrqywPdrkadsvefGsikvell
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 839-954 3.6e-34 112.7 In-house 36-149 (515) alignment 
Range on Protein: 839-954
Range on HMM: 36-149/515.0
IIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWP
 .  .| |   ||.|||  || .|..|      |  . .|.||||| .. . . .|||||| | .. |||||..||..  |.|||.|||| |.|| .|||
tvaqeeinfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

NGRAESDHFGSFTVTL
.  ..| .|||. | |
dkpgdsvkfGsikvel
subfamily_PTPN9_pd Subfamily PTPN9 808-955 3.9e-34 113.0 In-house 3-149 (297) alignment 
Range on Protein: 808-955
Range on HMM: 3-149/297.0
VDELGTHVATCHSNGFDEQYESLYTG-IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVD
..|| ..|   . .|  ..|. .    .  .        |   ||....  ||. |. ||   . .  . .||||...|||   . ||| |||.|||  |
ieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsd

FWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLT
|||..|... . |||.| . |  . || ||||... .|..||...|.  
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 841-957 5.8e-33 109.1 In-house 4-115 (250) alignment 
Range on Protein: 841-957
Range on HMM: 4-115/250.0
GYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSkCEQYWPNG
. . .|   ||. .|  .|  |..| ...  . .  .|||||...||. .. |||.|||...|..||||....||  .|||.|||||  |  ..||||  
akkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

RaeSDHFGSFTVTLTNE
.  ....|. ||.| ..
k..aekyGdvtvsllsk
0040439 (Phosphotyrosine protein) phosphatases II 838-957 6.5e-33 109.8 In-house 3-118 (249) alignment 
Range on Protein: 838-957
Range on HMM: 3-118/249.0
CIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
. ... .||   ||...|  || .|..| . ..|  .   |||||||||| ....||| |||...|. ||||..|...  .|||.|.|.|  . ||.|||
ysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PNgrAESDHFGSFTVTLTNE
|.   .|  .| |||||...
pl..ggsleygdftvtllsv
subfamily_PTPN12_pd Subfamily PTPN12 840-958 1.3e-31 104.6 In-house 34-150 (290) alignment 
Range on Protein: 840-958
Range on HMM: 34-150/290.0
IGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN
 | .|||.. ||.|.|  || .|. |  ... .  . .||||..| | ... ..||.|||. ||| ||||.||. .   .||. .. |  | |||.|||.
agekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

GRAESDHFGSFTVTLTNEQ
   |. .||.|.|||..|.
egeeelefgefevtleeek
0042113 (Phosphotyrosine protein) phosphatases II 842-957 3.3e-31 104.0 In-house 5-116 (245) alignment 
Range on Protein: 842-957
Range on HMM: 5-116/245.0
YNEENTAFNRFKNITVYDDNRIILAPNRKLDMCQreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgr
. .||  .||...|  ||..|..| |      .   ||||||.|||  ..||||.|||...|. ||||..|...  .|||.|.. |  . ||.||||.  
llpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

AESDHFGSFTVTLTNE
 ||  .| |||||..|
gesltygdftvtllse
subfamily_PTPN3_pd Subfamily PTPN3 826-957 3.2e-30 100.0 In-house 20-149 (280) alignment 
Range on Protein: 826-957
Range on HMM: 20-149/280.0
QYESLYTGI-DKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKlDMCQREYINASyIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTN
|.| ||    .  . .    || . ||...|. ||. |..|  ... |    .|.|   |.. . .|..||.|||..||  |||...|..|   |||.|.
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnme.ipstglvnryiatqGPlaktatdfWqmvweqksslivmltt

LKEGTKSKCEQYWPNgRAESDHFGSFTVTLTNE
| |  . || ||||.   .. ..|.|.|....|
lverGrvkChqyWPe.tedeleygefsvkceke
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 845-956 7.5e-29 96.0 In-house 60-163 (319) alignment 
Range on Protein: 845-956
Range on HMM: 60-163/319.0
ENTAFNRFKNITVYDDNRIILAPNRKLDMcqREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNGRAES
.|   ||. ||  .| |.. | .    ..   .|||||...|| . .|.||.|||.. || ||||.||. .  .||..|      | || ||||.   . 
qnkdknriinilafdknvvklerliGeef..sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

DHFGSFTVTLTN
.  .   |.. .
eerfkvkvdsve
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 848-954 1.1e-28 95.2 In-house 30-138 (274) alignment 
Range on Protein: 848-954
Range on HMM: 30-138/274.0
AFNRFKNITVYDDNRIILAPNRKLDmCQREYINASYIDGYSSSN-KFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAE--S
  ||.|.|   .  |..| ..   |  . .|||| || ||.  .  ..| |||. .|. ||||.|.||.   |||.|.|||  ..||..|.|. .    |
tknryktilPnensrvllesessed.edssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

DHFGSFTVTL
...| . .. 
erygdveikv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 845-956 1.2e-28 95.4 In-house 24-127 (284) alignment 
Range on Protein: 845-956
Range on HMM: 24-127/284.0
ENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNGRAES
.|   ||. .|  .| |.. | .    .    .|||||.| || . .|.||.|||.. || ||||.||. .  .||..|      | || ||||.   . 
qnkdknrighilafdknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

DHFGSFTVTLTN
.. .   |.. .
eerfkvkvdsve
subfamily_PTPN23_pd Subfamily PTPN23 841-957 1.4e-28 94.5 In-house 38-149 (288) alignment 
Range on Protein: 841-957
Range on HMM: 38-149/288.0
GYNEENTAFNRFKNITVYDDNRIILApnrkldMCQREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN
   . ..  ||...|  || ||. |         . .|||||.. . |. . .|||.|.|...|| |||......|   |||... .|  | |...|||.
aiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe

GRAESDHFGSFTVTLTNE
 . |. .|| ..||| ..
dkgetvkfgdlsvtlksv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 839-955 2.3e-28 94.3 In-house 41-154 (325) alignment 
Range on Protein: 839-955
Range on HMM: 41-154/325.0
IIGYNEENTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLI--WQekpVSIVMVTNLKEGTKSKCEQY
 .    || | |||||.  .| .|..|    | |  . .||||||.  .   . |.|.| |. .|. |.|||.  |.    |.|.|.|  .. | .| .|
kvamkpenkaknrfknvvaldksrvvle..tkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavy

WPNGRAESDHFGSFTVTLT
||.  ..| .||.. | | 
wpkemgksktfGglevklr
0037934 (Phosphotyrosine protein) phosphatases II 839-957 2.5e-28 94.7 In-house 3-110 (243) alignment 
Range on Protein: 839-957
Range on HMM: 3-110/243.0
IIGYNEENTAFNRFKNITVYDDNRIILapnrklDMcqREYINASYIDGYsssNKFIASQGPMKKTLVD----FWRLIWQEKPVSIVMVTNLKEGTKSKCE
 |.  .||   ||...|  ||..|..|      .     ||||..|...   ...||.|||...|. |    |||..|...  .|||.|.|.| .. ||.
siallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPngraESDHFGSFTVTLTNE
||||    .. ..| |||||..|
qywp....gevtygdftvtllse
subfamily_PTPN14_pd Subfamily PTPN14 834-953 4.3e-28 93.2 In-house 37-157 (300) alignment 
Range on Protein: 834-953
Range on HMM: 37-157/300.0
IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmcQREYINASYIDGYSSS--NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKS
 |  .  . ..||.  ||||..  |.|||. |.|...    . .||||| |    ..   ..|..|||...|. |||...|...   |||.|. .|. | 
edallstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgke

KCEQYWPNG--RAESDHFGSFTVT
|. .|.|.   .... .|| | ||
ksfkyfPkleskkktvefgkfkvt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 823-955 5.7e-28 92.9 In-house 28-153 (297) alignment 
Range on Protein: 823-955
Range on HMM: 28-153/297.0
FDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSsnKFIASQGPMKKTLVDFWRLIWQEKPVSIVMV
| |..  | .   .      .  |   .|.|||  || .|..||     |  . .|.|||.. |.    ..|..| ||| |. |||.....|..  |||.
fseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml

TNLKEGTKsKCEQYWPNGRAESdhFGSFTVTLT
....|..| || .||..    .  ||. .|.|.
nddnerdk.kcaryWsdkgvtt..fGdvsvvll
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 845-944 1e-27 91.8 In-house 19-117 (270) alignment 
Range on Protein: 845-944
Range on HMM: 19-117/270.0
ENTAFNRFKNITVYDDNRIILAPNRKldMCQREYINASYIDGYSSS-NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAE
 ....||...|      |..|.. ..    . .|||| |. |.... .|.||..||.. || .|||.||.||  .|||.|.|.|  ..|||.|||. . |
rgkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

S
.
k
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 845-956 9.3e-27 88.8 In-house 2-109 (237) alignment 
Range on Protein: 845-956
Range on HMM: 2-109/237.0
ENTAFNRFKNITVYDDNRIILAPNRKLdmcqREYINASYIDGYSSS-NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaE
|| . ||. ||..|| .|..|  .        .||||.|..|.  . .|.||.|||.. .  |||...||||   |||.| | || . || .|||.   .
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.q

SDHFGSFTVTLTN
   .| .||.|. 
paaygvltvslkk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 846-955 3.5e-25 83.4 In-house 38-143 (287) alignment 
Range on Protein: 846-955
Range on HMM: 38-143/287.0
NTAFNRFKNITVYDDNRIILAPNRKLDMcqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGrAESD
..  ||. ..  .||.|..|. . .|     .|||| |. .|   ..|||.|||.  |. ||||......  |....|   | .. || .|||.      
avkknryadvlPiddtrvllsaegelGs...dyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPm

HFGSFTVTLT
  | ..|.| 
rvGGysvvll
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 818-940 5.4e-25 82.6 In-house 17-145 (392) alignment 
Range on Protein: 818-940
Range on HMM: 17-145/392.0
CHSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPV
 ||  | |..  |      .  .. .| |   ||.|||  || .|..|      |. ...|.|||||... . . .||||||   .| ||||...||.. 
rhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkle..viddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvt

SIVMVTNLKEGTKS----KCEQY----WPNG
.|.|||.|||| |      . |.    ||. 
tiamvtklkegdkgddartvaqfhftewPdk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 846-942 1.6e-24 81.4 In-house 8-103 (239) alignment 
Range on Protein: 846-942
Range on HMM: 8-103/239.0
NTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRA
| | ||. ||  || .|..|   .  .  . .||||||.  |  | | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.  .
nkaknryanivtydhsrvvle..klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 846-942 1.7e-24 81.3 In-house 7-102 (239) alignment 
Range on Protein: 846-942
Range on HMM: 7-102/239.0
NTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYIDGYSSSNK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRA
| | ||. ||  || .|..|   .  .  . .||||||.  |  | | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.  .
nkaknryanivtydhsrvvle..klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts
subfamily_PTPN13_pd Subfamily PTPN13 836-954 3.7e-24 80.4 In-house 27-141 (273) alignment 
Range on Protein: 836-954
Range on HMM: 27-141/273.0
KRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldmcqreYINASYIDGYSSSNKF--IASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
..| .| ..||.. ||..|.  ||. |..|  .         |||||.|      ...  ||.|||. .|  |||...|. |   |.|||. ||. | ||
dtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkc

EQYWPNGRAESDHFGS-FTVTL
..|||. . ..    . ..|.|
hrywPesknkklkvsnrlevel
subfamily_CG7180_pd Subfamily CG7180 836-957 6.8e-24 79.0 In-house 32-148 (296) alignment 
Range on Protein: 836-957
Range on HMM: 32-148/296.0
KRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQ
  |  |...||   ||  ..  || ||..|      .  . .||||.|.|..   ...|  ..|.|.|. .||||...|.  ..|..|.  . .| .. .
gdCagglrkenreknrdvkvvPyDynRvvLekldGee..ksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myps

YWPNGRaeSDHFGSFTVTLTNE
||||      ..| . | ...|
ywpnks..keqygeifveivee
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 848-953 2.2e-23 77.6 In-house 35-138 (297) alignment 
Range on Protein: 848-953
Range on HMM: 35-138/297.0
AFNRFKNITVYDDNRIILapnrKLDMCQREYINASYIDG--YSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESD
  ||...|  .||.|. |    .  . .|.|||| |.      .  |.| .|||...|. |||.|....    ||||..|.|. ..||  |||.   |  
rknryrdilatddtrvkl....lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

HFGSFTVT
. |.. | 
kagdvvve
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 837-957 3.4e-23 76.7 In-house 48-160 (290) alignment 
Range on Protein: 837-957
Range on HMM: 48-160/290.0
RCIIGYNEENTaFNRFKNITVYDDNRIILApnrklDMCQREYINASYIDGYSssNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQY
| |.  | | .  ||.|...  |  |.||      |  . .|. | |..|      || .||..|.| .|.||.. |||   |||. .| |  |.|||||
rkifdkntefk.knrykdvvcndktrvilk.....dGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPNGRAESDHFGSFTVTLTNE
.|.   |   ||..||. ..|
ypekeGevltfGeitvlcsee
subfamily_PTPN1_pd Subfamily PTPN1 842-944 1.8e-22 74.4 In-house 28-125 (290) alignment 
Range on Protein: 842-944
Range on HMM: 28-125/290.0
YNEENTAFNRFKNITVYDDNRIILAPNRKldmcqrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
 ..|| . ||..... ||  ||.|  . .      .||||| ..      ..| .|||. .|   ||...|..|  ..||. .. |  . || ||||.| 
klpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

A-ES
  ..
eeke
subfamily_PTPRN_pd Subfamily PTPRN 833-956 8e-22 72.3 In-house 43-163 (297) alignment 
Range on Protein: 833-956
Range on HMM: 43-163/297.0
GIDKRCIIGYNEENTAFNRFKNITVYDDNRIILApnRKLDMCQREYINASYID-GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKS
  .. . .. .|.|   || |..  ||..|. |   .. .  . .||||| |      .  .||.|||. .|. |||...|..  | ||..|.|.|   .
aepstkevakaeknvkknrskavlpydhsrvklk..eeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvk

KCEQYWPNGRAESDHFgsFTVTLTN
.|..|||.  .|  |.  . | |  
qckrywpdeGsevyhi..yevhlvs
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 823-940 2e-21 70.9 In-house 22-135 (439) alignment 
Range on Protein: 823-940
Range on HMM: 22-135/439.0
FDEQYESLYT-GIDKRCIIGY--NEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSI
|.| .|.. .   | .||     .| . . ||.|... .|  |..|       . .  |||| ||.||   . .||.||| |.|  |||||....| | |
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeip..gvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

VMVTNLKEGTKskceqYWPNG
||.||| |  |     |||  
vmltnlvesyk.....ywpsd
subfamily_egg_pd Subfamily egg 842-953 1e-20 68.6 In-house 36-145 (307) alignment 
Range on Protein: 842-953
Range on HMM: 36-145/307.0
YNEENTAFNRFKNITVYDDNRIILapNRKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtkSKCEQYWPNGR
....|    | | .   |  |. |  . .  .   ..| | ...|    |.|| .| |.| |  ||||...||.   |||.|  ||    .|| |||.  
asdnnlekarskrvhckdssrvkl..elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

AESDHF--GSFTVT
..|  .  ||. ..
sdslvtvpGslrie
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 845-944 1.2e-20 68.5 In-house 46-157 (350) alignment 
Range on Protein: 845-944
Range on HMM: 46-157/350.0
ENTAFNRFKNITVYDDNRIILA-----P-NRKLDMCQREYINASYIDGY------SSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSK
|  | ||.|||  |. .|..|      .  .|  .   .||||.|.          .. |.|| |.|...|. ||...| . |   |...|.. |    |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CEQYWPNGRAES
|..||..|  . 
cyrYWqegsydd
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 845-955 4.7e-20 66.8 In-house 40-146 (307) alignment 
Range on Protein: 845-955
Range on HMM: 40-146/307.0
ENTAFNRFKNITVYDDNRIILapnrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAES
 ||  ||.... . | .||..    |.|    .|| | |.      .|||..|||...|  .|| .. |||  |..|. .. | .| |||||||  . . 
antdknryqdvkcqdkgrivv....kfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

DHFGSFTVTLT
  ||. . |..
lvfgeapntis
subfamily_ptpA1_pd Subfamily ptpA1 840-940 1.5e-19 65.0 In-house 41-138 (418) alignment 
Range on Protein: 840-940
Range on HMM: 41-138/418.0
IGYNEENTAFNRFKNITVYDDNRIILapNRKLDMCQREYINASYIDGYsSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN
 | .. ||. ||. ||   .  |. |  ..  |    .|||| ||||    ..||..|||. .|. ||||..|...   |||..   |  . ||..|||.
egdkkhntsknrytnilpvnhtrvql..kkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpe

G
 
q
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 834-953 1.6e-19 65.0 In-house 21-131 (267) alignment 
Range on Protein: 834-953
Range on HMM: 21-131/267.0
IDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLdmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtksKC
.  ..   . |.| ..||. .   |||.|.||  . .       ||||||..||   |.||. |.|.|.|  ||. .| ..|   ||..|.  ..   . 
tsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...ni

EQYWPNGRAESDHFGSFTVT
 ..||   ... ..  .|| 
rlfwPPkmgqakkyqdltve
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 821-953 5.2e-19 62.9 In-house 27-155 (310) alignment 
Range on Protein: 821-953
Range on HMM: 27-155/310.0
NGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKldmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
.|.  ||  | .  |        ...   ||. .. . |. |. |  ..       .|| | |.      . || ||||...|..||||.|.||.  ||.
eglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidks...ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MVTNLKEGTKSKCEQYWPNGrAESDHFGSFTVT
.. .  |  . ||  |||     .. .|   ||
llckvgeegrpkcvgywpsl.gvtetygcirvt
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 843-956 3.1e-18 60.8 In-house 26-140 (285) alignment 
Range on Protein: 843-956
Range on HMM: 26-140/285.0
NEENTAFNRFKNITVYDDNRIILAPNRKLDMCQREYINASYIDGYS-SSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
|   ||..   ..  | | | |      |   .|.|| ||..       . .|..|||. .|| |||..|.|||   ..|.  | ||   ||  |.|.  
nctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

AESDHFGSFTVTLTN
 |  .|| . .|||.
gevvkfgkyeitlte
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 838-952 1.1e-17 58.6 In-house 29-142 (281) alignment 
Range on Protein: 838-952
Range on HMM: 29-142/281.0
CIIGYNEENTAFNRFKNITVYDDNRIILAPNrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
| .  .  |   ||. || . |  |. |  .   .    .|| | ||        .| .||| |.|  ||||.||||.  .|||. .. |  . || .|.
ctvfnqpvnnkknrylnipcldisrvqlkvk.mpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyf

PNGRAESDHFGSFTV
|       .|  ..|
prnahcclqfdklsv
0049772 (Phosphotyrosine protein) phosphatases II 835-931 1.5e-17 59.8 In-house 35-157 (314) alignment 
Range on Protein: 835-931
Range on HMM: 35-157/314.0
DKRCIIGYNEENTAFNRFKNITVYDdNRIILapnRKLDMCQREYINASYIDGYsssNKFIASQGPMKKTLVDF----------WRLI--WQEKPVSIVM-
.. . ... ..|   ||...|  .| || ||    .|..    ||||||.||.   .||||.|||.. |.|||          ||..  .. ..  ||| 
eltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------VTNLKEGTKS
                     ..| ...  
rdevladelsrLdaAlgKtpllildgngne
0041856 (Phosphotyrosine protein) phosphatases II 846-940 2.7e-17 58.4 In-house 1-74 (182) alignment 
Range on Protein: 846-940
Range on HMM: 1-74/182.0
NTAFNRFKNITVYDDNRiilapnrkldmcQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtkskCEQYWPNG
|   ||...|  || .|               ||||....|.  ...||| |||...|. ||.|......  .||..|         .|.|||. 
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpel
subfamily_CG42327_pd Subfamily CG42327 871-956 3.6e-17 57.0 In-house 51-139 (319) alignment 
Range on Protein: 871-956
Range on HMM: 51-139/319.0
LDMCQREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRA--ESDHFGSFTVTLTN
 |  . ||..|||. || .  | .||.| .....  ||||..|. .   || .|.| |    .| .|.|   .  . . .| . ||| .
gdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkg
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 846-941 6.8e-17 56.1 In-house 48-138 (305) alignment 
Range on Protein: 846-941
Range on HMM: 48-138/305.0
NTAFNRFKNITVYDDNRIILAPNrkldmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
..  ||.|..   |.||. | .         ||| | |.   . ...|| .| |..||  ||| . .|.|  .| |. ||.|    || .|..   
eagknrykdvgcldnnrvklegp.....wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd
0051429 (Phosphotyrosine protein) phosphatases II 877-954 9.1e-16 53.8 In-house 5-94 (272) alignment 
Range on Protein: 877-954
Range on HMM: 5-94/272.0
EYINASYIDGYSS---SNKFIASQGPMKKTLVDFWRLiWQEKPVSIVMVTNLKEGTKSKCEQYWP----------NGRAESDHFGSFTVTL
 ||||....|| .    .....|.||.. |  ||||| ....  .||..... |  . ||..|||          .  |..  .| ..|||
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtl
fn3 Fibronectin type III domain 186-261 8.4e-15 47.9 Pfam-A 1-79 (85) alignment 
Range on Protein: 186-261
Range on HMM: 1-79/85.0
SAPTSLTKLNKTTTTITVSWTALD--SSDADGYVVNVTSDTDT--VQTVQVKGSSNnAATLNGLREGTTYSITVRAYQQL
|||. |.  . |.|..|.||.. .  ... .|| | . .....   ....|.....  .||.||..||.|...|.|. . 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 846-947 1.9e-14 48.0 In-house 55-152 (305) alignment 
Range on Protein: 846-947
Range on HMM: 55-152/305.0
NTAFNRFKNITVYDDNRIILAPNRkldmcQREYINASYIDGYS-SSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAES
. . ||.... . | . . |.          .|| | |.       ..||..|||. .|. .|| .. |.|   |||. .  |  | || ||||  . | 
aitknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

DHF
 ..
lel
0036282 (Phosphotyrosine protein) phosphatases II 877-943 2.1e-14 49.1 In-house 3-64 (174) alignment 
Range on Protein: 877-943
Range on HMM: 3-64/174.0
EYINASYIDGYSSSNKFIASQGPMKktlvdFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAE
 |||||..|..  ....||.|||..     ||.......  ..||....||  . || .|||  |  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelred
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 874-957 2.6e-13 44.4 In-house 73-156 (301) alignment 
Range on Protein: 874-957
Range on HMM: 73-156/301.0
CQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNE
 .|  | | .|.    ...|||.|||.|.|  ||| .. | .   |||...  | ...|||.| |   .|. . | |.....|.
GkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 805-898 9.8e-13 42.1 In-house 4-95 (95) alignment 
Range on Protein: 805-898
Range on HMM: 4-95/95.0
PVSVDELGTHVATCHSNG---FDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDmcqreYINASYIDGYSSSNKFIASQG
|. |  . .||   |||    ||... |.         .|  | |   ||| ||  ||  |..|. .|  |     |||| ..|||.  | .||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsd.....yinacfvdgyarkncyiaaqg
0046846 (Phosphotyrosine protein) phosphatases II 877-941 2.5e-12 42.4 In-house 13-73 (176) alignment 
Range on Protein: 877-941
Range on HMM: 13-73/176.0
EYINASYIDGYsssnKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
 ||||..|.|.    ..|| |||. .|| ||........   .|..|...|  . || .|||  .
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpele
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 821-950 2.6e-12 41.4 In-house 19-141 (288) alignment 
Range on Protein: 821-950
Range on HMM: 19-141/288.0
NGFDEQYESLYTGIDKRCIIGYNEeNTAFNRFKNITVYDDNRIILApnrklDMCQrEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
.| . .|.    .  .. |  . . |.. .|..|.   |  |. |      | ..  ||.|  .      ...| .| |.. |.  .|... ..    ||
eglkkeyrdspneasidiidsfia.nptrdryenlprcditrvkls.....ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyiv

MVTNLKEGTKSKCEQYWPNGRAESDHFGSF
|...| |  | | ..|.|    |. ..| .
mlcellekGkeksaeyfPsklGekarigrl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 885-953 4.8e-12 39.9 In-house 230-294 (440) alignment 
Range on Protein: 885-953
Range on HMM: 230-294/440.0
DGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTkskCEQYWPNgRAESDHFGSFTVT
.|||  | |||.| |.  |..|||||. . .  .|.|. .|.. |   |  |||   . |  || ||| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpv.ntrsvtfgpftvg
0043147 (Phosphotyrosine protein) phosphatases II 876-926 7.5e-12 40.8 In-house 5-55 (172) alignment 
Range on Protein: 876-926
Range on HMM: 5-55/172.0
REYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLK
. ||||||.|.|   ..||| |||.  || ||||......   ||..|.| 
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltell
fn3 Fibronectin type III domain 460-548 8.2e-12 38.3 Pfam-A 1-84 (85) alignment 
Range on Protein: 460-548
Range on HMM: 1-84/85.0
SPVTSLSVSNVSTTGIRVKWTIP-SSDNYVTYYTISYTPSCPQLssVNERVSVGPHqstTRySYTLIGLYSGMNYTITVRAGNVLGGSKL
|... ||||.|..| ....|. | . .  .|.|.. | ..  .   .  ...| ..   |. |.|| ||  |..|...|.| |  |... 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprt...tt.svtltgLkpgteYefrVqavngagegpe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 845-943 1.6e-11 38.2 In-house 47-159 (349) alignment 
Range on Protein: 845-943
Range on HMM: 47-159/349.0
ENTAFNRFKNITVYDDNRIILAPNRK-----------LDMCQ-REYINASYID--GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTK
|  | ||.|.|  |.  |..|    |            | ..  .|||| |.    .|  .|.|| | |.  |. ||...|  ..   .. ... || . 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

SKCEQYWPNGRAE
 ||..|| ..  .
ekcdiywqelsys
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 836-923 4.2e-11 37.0 In-house 27-117 (347) alignment 
Range on Protein: 836-923
Range on HMM: 27-117/347.0
KRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRKLDM---CQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVT
 ..     | . . || |.  . |. |..|.|..           |||||.|    .|...| .| |. .|. |||...   |   .| . 
skftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
fn3 Fibronectin type III domain 564-643 4.6e-11 35.9 Pfam-A 3-85 (85) alignment 
Range on Protein: 564-643
Range on HMM: 3-85/85.0
PSSIQVFQVNSTANRFTWNEVNcsERNGLITGYTVIISNS-----SITYNLTSTERYIILNDLVFGTEYNISVAAINSVGRGPFS
|. ..| .|.||  ...|.. .  ...| ||||.|  ...     . ......|..  .|..|  ||||...|.|.| .| ||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
0049260 (Phosphotyrosine protein) phosphatases II 883-937 5.4e-11 37.9 In-house 1-55 (152) alignment 
Range on Protein: 883-937
Range on HMM: 1-55/152.0
YIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
.||||  ...||| |||.  || ||||.... .   |||.|.| | .| |||||.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 846-933 3.8e-10 33.8 In-house 34-118 (332) alignment 
Range on Protein: 846-933
Range on HMM: 34-118/332.0
NTAFNRFKNITVYDDNRIILAPNRKLDmcqrEYINASYIDGYSSSNKFIASQGPMK-KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
|  .||   . ..| .|. |||.   |    .. |||..||||  . .| .| |.. .|   |||.. . ||  |... .. |  | |.
nmdmnriphlycfdhsrvelapqdgkd....dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 890-954 5.5e-10 33.7 In-house 4-68 (199) alignment 
Range on Protein: 890-954
Range on HMM: 4-68/199.0
SNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTL
  ..||.| |...|. |||...|.     |||| . .   ..    |||   . . ..||..|| 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 891-954 6.5e-10 33.5 In-house 4-67 (198) alignment 
Range on Protein: 891-954
Range on HMM: 4-67/198.0
NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTL
 ..||.| |...|| |||...|.     |||| . .   ..    |||   . . ..||..|| 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt
0051082 (Phosphotyrosine protein) phosphatases II 877-939 2.4e-09 32.5 In-house 4-55 (151) alignment 
Range on Protein: 877-939
Range on HMM: 4-55/151.0
EYINASYIDGYsssnkFIASQGPMKktlvDFWRLIWQEKPVSIVMVTNLKEGTksKCEQYWPN
 |||.||..|.     ...|.||.     ||..|.....  .||......|    .| .|.|.
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpe
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 849-937 3e-09 31.0 In-house 46-128 (312) alignment 
Range on Protein: 849-937
Range on HMM: 46-128/312.0
FNRFKNITVYDDNRIILAPNRKLdmcqreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
.||. || ..|  |. || . ..      || | ..   .  ..|...|||...| . ||.|      .||.... . | .  || .| 
lnrypniqcwdrgrftlagdenf......yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi
0044763 (Phosphotyrosine protein) phosphatases II 870-940 4.7e-09 31.6 In-house 12-73 (178) alignment 
Range on Protein: 870-940
Range on HMM: 12-73/178.0
KLDMCQREYINASYIDGYsssnKFIASQGPmkktlVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG
  ...  .|||||.|...     ...|..|     .|...|.....  .||..|. .|. . || .||| .
leglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpee
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 825-950 5.3e-09 29.9 In-house 33-151 (302) alignment 
Range on Protein: 825-950
Range on HMM: 33-151/302.0
EQYESLYTGIDKrCIIgyNEENTAFNRFKNITVYDDNRIilapnrKLDMCQREYINASYIDGYSSSNKFIASQGPMKKTL---VDFWRLIWQEKPVSIVM
.. ... . ..| | .    .|...|. ... ..|.|..      ||.... .|.||| ..  . ... | .| | ...     .|||...||| ||.|.
kkidtmkvdlek.Cka..fkknlkknqsedvpildsnlv......kleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvi

VTNLKEGTKsKCEQYWPNGRAESDHFGSF
.   .| .|   ....|.   .  ..|..
lvgeeelkk.tlselfpkksgdykeygkm
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 842-956 7.6e-09 29.5 In-house 92-197 (244) alignment 
Range on Protein: 842-956
Range on HMM: 92-197/244.0
YNEENTAFNRFKNITVYDDNRIILApnrKLDMCqREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWqEKPVSIVMVTnlkeGTKSKCEQYWPNGR
.| .|.  ||      .| ||. |.   |  |    |||||..     . ..| .| |.  | .|||...  |. | ...|     |.  . ..|||.  
fnpnnswknregaglpfdfnrvpls...kgsmg.ntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvl....gsveeedeywpdse

AESDHFGSFTVTLTN
    .    |||||.
plewyeeditvtltd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 855-955 1.3e-08 29.4 In-house 27-135 (290) alignment 
Range on Protein: 855-955
Range on HMM: 27-135/290.0
ITVYDDNRIILAPNRKLdmCQREYINASYIDgYSSSNKFIASQGPMKKT-------LVDFWRLIWQEKPVSIVMVTNLKEGTKS----KCEQYWPNGRAE
...  ..|..|    |    . .|| |...  ...  ..|..| | .|.       . .|| .. |||  ..||. . .| ..      |..| |.   |
vpLveatrvvLkgygkr..fnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge

SDHFGSFTVTLT
.  |. .||  .
elkfkgltvkCk
subfamily_eak_pd Subfamily eak 845-953 2.7e-07 24.3 In-house 51-155 (332) alignment 
Range on Protein: 845-953
Range on HMM: 51-155/332.0
ENTAFNrFKNITVYDDNRIILAPNRKldmCQREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAES
|.   |   .|  || . . |.. ..    .  ||||| ..     .|.| .  . .. .  ||... ..|  .||.. .  |    | ..|.|.   | 
eavnrn.vvkivpydrylvrltssql...nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

DHFGSFTVT
 .|| . |.
lkfGildve
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 903-956 3e-07 24.8 In-house 40-93 (255) alignment 
Range on Protein: 903-956
Range on HMM: 40-93/255.0
TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTN
|.  |.. | | |.  .||.....| .. ||..|.|  . |   .   .|| |.
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk
subfamily_hpo-7_pd Subfamily hpo-7 901-957 1.1e-06 22.7 In-house 44-100 (263) alignment 
Range on Protein: 901-957
Range on HMM: 44-100/263.0
KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESDHFGSFTVTLTNE
 .|.  |.. | | |.  .||... .|  . ||..|.|  . |   .   .|. |. 
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 849-922 7.8e-06 19.7 In-house 50-114 (303) alignment 
Range on Protein: 849-922
Range on HMM: 50-114/303.0
FNRFKNITVYDDNRIilapnrklDMCQREYINASYIDgYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMV
 ||| .. . |  ..         ...  || |||..   ||.| | .| |. .|  |||..| ..|   ....
knrfvdvicldhskv........klsdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlll
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 817-886 9e-06 19.3 In-house 18-85 (440) alignment 
Range on Protein: 817-886
Range on HMM: 18-85/440.0
TCHSNGFDEQYESLYTGIDKRCIIGYNEENTAFNRFKNITVYDDNRIILAPNRklDMCQREYINASYIDG
   |  |....  | .|. . . |    .|   ||..|| .|| .|..|   .   . . .|||||||.|
nrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevk..gvpdsdyinasying