Gene PTPRD-56 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP113_AA protein Get Run
AqueP113_AA_812-971 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 878-978 1.5e-68 225.7 In-house 201-301 (301) alignment 
Range on Protein: 878-978
Range on HMM: 201-301/301.0
NGIVREPHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHSTYA
.|.||||.|.||||||||||||||||||||||||||||||||||||||.||||||||||||||||||.||||||||||||||||||||||||..|.||||
dGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstya

N
|
n
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 878-972 5.2e-38 125.9 In-house 191-285 (305) alignment 
Range on Protein: 878-972
Range on HMM: 191-285/305.0
NGIVREPHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKL
.|..... ..|..|..| ..|.|  | |..||||..|.|.||...|.||||..|.|.|||||.|.|..|......|.||.||....|..| . . 
hGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
0050432 (Phosphotyrosine protein) phosphatases II 823-978 1e-36 122.2 In-house 57-307 (308) alignment 
Range on Protein: 823-978
Range on HMM: 57-307/308.0
EKPCTIGYSEENKPFNRFKNITVYDDNRIILatnpnlDmCQREYINASYVDGY-----------------------------------------------
  ...... .|||..||.|.|  || .|..|      |     ||||||||||                                               
lleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrek

----------------------------------------------------------SSNGIVREPHTILQVIDDVIHRQqkiGGGPVVVHCSDTVSRS
                                                             |.  .|  .|. .. | ...   .|||.|||||. |.|.
caqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRt

GVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHSTYAN
|... . ..||| ..|| ||||.. | .|. .||.|.|.|||  .|... .|.||. |..|
GtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkln
0046845 (Phosphotyrosine protein) phosphatases II 823-978 3.5e-35 117.2 In-house 17-282 (284) alignment 
Range on Protein: 823-978
Range on HMM: 17-282/284.0
EKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNlDMCQREYINASYVDGY-----------------------------------------------
. ...... .||.  ||.|.| .||..|..| . .. |.   .||||||||||                                               
llslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelveng

------------------------------------------------------------SSNGIVREPHTILQVIDDVIHRQQK-IGGGPVVVHCSDTV
                                                              .|.  .|  .|. ...| . ...  ||||.|||||. |
rekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGv

SRSGVYCSVSIALEQCKAEG---VVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHSTYAN
.|.|... . ..||| ..||   .|||... | .|. .||.|.|||||  .|... .|.||. |...
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
0040438 (Phosphotyrosine protein) phosphatases II 821-976 1.5e-34 115.1 In-house 30-282 (317) alignment 
Range on Protein: 821-976
Range on HMM: 30-282/317.0
GEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVDGY---------------------------------------------
    ...... .|||..||...|  ||..|..|   ..       |||||||||.                                             
lkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrek

-------------------------------------------------------SSNGIVREPHTILQVIDDVIHRQQkiG-GGPVVVHCSDTVSRSGV
                                                          |.   | ..|. .. | . ..  . ||||.||||. |.|.|.
caqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHSTY
.. . ..|||.. || |||... | .|. .||||.|.|||  .||.. .|.| . |.
fiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
0039614 (Phosphotyrosine protein) phosphatases II 820-973 1.9e-34 114.9 In-house 43-292 (297) alignment 
Range on Protein: 820-973
Range on HMM: 43-292/297.0
SGEEkPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDMcQREYINASYVDGYSS------------------------------------------
|  . ...|....|||..||.|.|  ||..|..| .... |.    ||||||||||.                                           
slkp.dysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr

-------------------------------------------------------NGIVREPHTILQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYC
                                                       .|.   . ..|.... | .....  .||||.||||. |.|.|...
kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfi

SVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLH
   ..|||.. || |||... | .|. .||||.|..||  .||.. ...| .
aaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0051299 (Phosphotyrosine protein) phosphatases II 824-970 3.3e-34 114.0 In-house 39-286 (288) alignment 
Range on Protein: 824-970
Range on HMM: 39-286/288.0
KPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVDGYS-----------------------------------------------
 ...... .||.. ||...|  ||..|..| . ..  .    ||||||.|||                                                
ltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaq

---------------------------------------------------------SNGIVREPHTILQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGV
                                                          .|.   |  .|. . .|.. ..  ||||||||||. |.|.|.
Ywplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgt

YCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYF
.. . ..||| ..||.|||... | .|. .||.|.|.|||  .|... .|.
fialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 824-975 4.3e-34 113.6 In-house 29-282 (297) alignment 
Range on Protein: 824-975
Range on HMM: 29-282/297.0
KPCTIGYSEENKPFNRFKNITVYDDNRIILatnpnlDMCQREYINASYVDGYS-----------------------------------------------
 ..... ..||.. ||.|.|  ||..|..|      |     ||||||||||.                                               
gslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaq

---------------------------------------------------------SNGIVREPHTILQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSG
                                                          .|.   | ..|. |. | ...... .||||.||||. |.|||
ywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsg

VYCSVSIALEQCK---AEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHST
... . ..|.| .    || ||.... | .|. .||||.|||||  .|... ...| . |
tfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0047943 (Phosphotyrosine protein) phosphatases II 823-970 3.7e-33 110.6 In-house 27-272 (273) alignment 
Range on Protein: 823-970
Range on HMM: 27-272/273.0
EKPCTIGYSEENKPFNRFKNITVYDDNRIILatnpnlDMCQREYINASYVDGYS----------------------------------------------
. ...... .||| .||.|.|  ||..|..|      ..    ||||||||||                                               
lltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekca

---------------------------------------------------------SNGIVREPHTILQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSG
                                                          .|.   .  .|. |..| . .... ..||||||||. |.|.|
qYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtg

VYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYF
... . ..|.| ..|| |||... | .|. .||.|.|.|||  .|... .|.
tfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 876-976 1.2e-32 108.0 In-house 189-289 (290) alignment 
Range on Protein: 876-976
Range on HMM: 189-289/290.0
SSNGIVREPHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHST
 |.| | .|.|||.||  ... | | | ...||||||||.||.|.|.. .....|| |||.||||| |  |  ||| |.| .||  |....  |..  .|
dstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet

Y
|
y
0043336 (Phosphotyrosine protein) phosphatases II 819-970 1e-31 105.9 In-house 30-277 (278) alignment 
Range on Protein: 819-970
Range on HMM: 30-277/278.0
KSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVDGYS------------------------------------------
 |    ...|....|||..||.|.|  || .|..|   ..       ||||||||||.                                          
lsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgr

----------------------------------------SNGIVR-----------------EPHTILQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGV
                                         .| .|                  . ..|. . .|.....   .|||.||||. |.|.|.
vkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGt

YCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYF
.. . ..||| . || ||.... | .|. .||||.|..||  .|... .|.
fialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 823-970 1.6e-31 105.6 In-house 44-304 (307) alignment 
Range on Protein: 823-970
Range on HMM: 44-304/307.0
EKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLdMCQREYINASYV--------DGY---------------------------------------
  ...|....|||..||.|.|  ||..|..| . ..  .    |||||||        |||                                       
lgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelv

---------------------------------------------------------------SSNGIVREPHTILQVIDDVIHRQQKI-GGGPVVVHCS
                                                                  |.   . ..|. |. | . ...  .||||.||||
elgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

DTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYF
. |.|.|...   ..|.| ..||.   ||.... | .|. .||||...|||  .|... ...
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 877-979 5.3e-30 99.4 In-house 185-287 (287) alignment 
Range on Protein: 877-979
Range on HMM: 185-287/287.0
SNGIVREPHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHSTY
|.| | || ||| ||.. .. |.| | ...|||||||| ||...|.. .....|| |||.||||| |  |  |||.| | |||. |.|.. .| .  .||
stgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety

ANF
..|
sdf
0040439 (Phosphotyrosine protein) phosphatases II 825-970 1.5e-29 98.7 In-house 2-246 (249) alignment 
Range on Protein: 825-970
Range on HMM: 2-246/249.0
PCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDMCQreYINASYVDGYS------------------------------------------------
...... .|||. ||...|  || .|..|   |.|  .   ||||||.|||                                                 
eysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

----------------------------------------------------SNGIVREPHTILQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSV
                                                      |.   . ..|. |. | . ....  ||||.||||. |.|.|...  
wplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

SIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYF
 ..||| . |. ||.... | .|. .||||...|||  .|... ...
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 826-970 5.1e-28 93.5 In-house 1-243 (245) alignment 
Range on Protein: 826-970
Range on HMM: 1-243/245.0
CTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDMCQreYINASYVDGYS-------------------------------------------------
..... .|||..||...|  ||..|..|   ..   .   ||||||||||                                                  
ysvallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

----------------------------------SNGIVRE-----------------PHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSI
                                   .. .||                 . ..|.... | . ... ..|||.||||. |.|.|... . .
plgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

ALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYF
.||| ..|. |..... | .|. .||||.|..||  .|... ...
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 824-971 2e-26 88.4 In-house 23-273 (278) alignment 
Range on Protein: 824-971
Range on HMM: 23-273/278.0
KPCTIGYSEENKPFNRFKNITVYDDNRIIlatnpnldmcqrEYINASYVDGYsS----------------------------------------------
  .| .  ..|...||.|.|  || .|..            .||||||.||| .                                              
seitpalylgnldknRykdilpydhsrVk............dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

---------------------------------------------------------NGIVREP--HTILQVIDDVIHRQQK------------IGGGPV
                                                         .|.  .|    .|.... . .....             .||||
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

VVHCSDTVSRSGVYCSVSIALEQCkaEGVVDVFQVTKAIRRSKPG-AVTTLEQYTSIYDVIDMYFK
.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..||||  .|... ....
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 879-977 3.8e-26 87.0 In-house 199-297 (298) alignment 
Range on Protein: 879-977
Range on HMM: 199-297/298.0
GIVREPHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHSTYA
|. .. ...|.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  ...  ....
gvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 884-977 2e-25 84.4 In-house 156-249 (250) alignment 
Range on Protein: 884-977
Range on HMM: 156-249/250.0
PHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHSTYA
 ...|.....|   ||..| .||.|.||  |.||| .. ..  ||. | | |||||.| |..|. .|.||..|||| ..| .|  . .  . ||
atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 815-877 4.3e-25 83.0 In-house 21-83 (301) alignment 
Range on Protein: 815-877
Range on HMM: 21-83/301.0
THSLKSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDMCQREYINASYVDGYSS
 ..||.||.|.||.|.|||||..||||||||||||||||...||||.||||||||||.||||.
ykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgyse
subfamily_PTPRD_pd Subfamily PTPRD 878-976 1.1e-23 78.8 In-house 190-287 (564) alignment 
Range on Protein: 878-976
Range on HMM: 190-287/564.0
NGIVREPHTILQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHSTY
.|.  .. ..|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | | |||  |...|  . .  .| 
hgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 882-975 1.1e-23 78.8 In-house 195-288 (319) alignment 
Range on Protein: 882-975
Range on HMM: 195-288/319.0
REPHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHST
..  ..|... .. . ..|   ||.|||||. | | | .. ....||. | |||.|||.. . .|  ..  | . |||. ||...  . .  .|
ekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 879-977 6.6e-23 76.3 In-house 189-287 (318) alignment 
Range on Protein: 879-977
Range on HMM: 189-287/318.0
GIVREPHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHSTYA
|.  .. ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | .||. ||||.  . .   |..
gvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_PTPRA_pd Subfamily PTPRA 879-971 2.5e-21 70.9 In-house 205-296 (330) alignment 
Range on Protein: 879-971
Range on HMM: 205-296/330.0
GIVREPHTILQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFK
|.  ||  .|...  | . .|. .| |.|||||  | |.| .. ..  ||. |||..||||.. | .|  .|  | |.|||. || |.  |. 
GvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
0037934 (Phosphotyrosine protein) phosphatases II 825-970 3.6e-21 71.3 In-house 1-242 (243) alignment 
Range on Protein: 825-970
Range on HMM: 1-242/243.0
PCTIGYSEENKPFNRFKNITVYDDNRIILatnpnlDMcqREYINASYVDGYS----------------------------SNGIV---------------
...|. ..||.. ||...|  ||..|..|      .     ||||......                             .. ||               
sfsiallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

---------------------------------------------------------REPHTILQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRS
                                                          .|  .|. .|.|.  ...        .||||.||||  |.|.
ywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVYCSVSIALEQCkaeGvVDVFQVTKAIRRSKPG-AVTTLEQYTSIYDVIDMYF
|...   . |...   | ||.... | .|. .|| ||.|..||  .|... ...
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
DSPc_SM00195 879-971 5.5e-21 70.4 In-house 172-263 (263) alignment 
Range on Protein: 879-971
Range on HMM: 172-263/263.0
GIVREPHTILQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFK
|.  ... .|...  | ......  ||.|||||. |.|.|......|.|.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.|
gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 879-971 5.5e-21 70.4 In-house 172-263 (263) alignment 
Range on Protein: 879-971
Range on HMM: 172-263/263.0
GIVREPHTILQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFK
|.  ... .|...  | ......  ||.|||||. |.|.|......|.|.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.|
gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
Y_phosphatase Protein-tyrosine phosphatase 882-966 6.1e-21 70.3 Pfam-A 150-233 (235) alignment 
Range on Protein: 882-966
Range on HMM: 150-233/235.0
REPHTILQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
..|. .|..|..| ... .   ||||||||. |.|.|......|.|||..||. |||.|. | .|...||.|..||||  .|..|
espkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 882-966 6.1e-21 70.3 In-house 150-233 (235) alignment 
Range on Protein: 882-966
Range on HMM: 150-233/235.0
REPHTILQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
..|. .|..|..| ... .   ||||||||. |.|.|......|.|||..||. |||.|. | .|...||.|..||||  .|..|
espkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_CG7180_pd Subfamily CG7180 901-969 1e-20 68.6 In-house 221-289 (296) alignment 
Range on Protein: 901-969
Range on HMM: 221-289/296.0
IGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMY
   |||||..|| .||||||... ..||. . |. ||||.  | .|||.|. | . |.|  ||||.  .
peegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
PTPc_DSPc_SM00012 874-966 1.1e-20 69.2 In-house 9-103 (105) alignment 
Range on Protein: 874-966
Range on HMM: 9-103/105.0
GYSSNGIVREPHTILQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
|..  |. .|.. ||.....| . ..|.. ..|||||||. |.|.|... ..|.|.|...| . ||.||. |..|...||.|.|.|||  .|...
gwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 817-965 1.8e-20 67.7 In-house 30-189 (440) alignment 
Range on Protein: 817-965
Range on HMM: 30-189/440.0
SLKSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVD-------------GYSSNGIVREPHTILQVIDDVIHRQQKIGG
 | ||  .|. |    .||  ||..|| .|| .|..|       . . .||||||..             |.  .|. .    .|..|.|| . |.| | 
llpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevk..gvpdsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagn

GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDV
||..||||  ..|.||  .|   | ..|    .|.| . ...| ..|  | | |||. ....
gpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea
subfamily_PTPRK_pd Subfamily PTPRK 885-966 1e-19 65.5 In-house 193-273 (314) alignment 
Range on Protein: 885-966
Range on HMM: 193-273/314.0
HTILQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
...|...  | . |.. . |..|||||    |.|... ..| |.  . |||||||.. |..| .|.  | | |||. |||||
tgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 891-966 2.1e-18 61.2 In-house 187-262 (283) alignment 
Range on Protein: 891-966
Range on HMM: 187-262/283.0
IDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
.. ||  |..   ||.||||| .. |..|....| .... ..| |||||.| | .|  ...|| ||.||  .....
fnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Ptp69D_pd Subfamily Ptp69D 883-969 6.1e-18 60.0 In-house 200-285 (307) alignment 
Range on Protein: 883-969
Range on HMM: 200-285/307.0
EPHTILQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMY
 ....|..|. | . ...   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  .  |
vargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_PTPRG_pd Subfamily PTPRG 899-966 6.9e-17 55.9 In-house 216-283 (563) alignment 
Range on Protein: 899-966
Range on HMM: 216-283/563.0
QKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
.|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | ||  ..  |.| |||. ..|..
nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 882-971 8.4e-17 56.1 In-house 178-269 (274) alignment 
Range on Protein: 882-971
Range on HMM: 178-269/274.0
REPHTILQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFK
....|.|.....| . ...     .|||||||  . | |.. ..|||. | ..|.||||....  .|  . | | | |||  |. .. .| |
ddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 889-967 1.1e-16 55.7 In-house 199-276 (315) alignment 
Range on Protein: 889-967
Range on HMM: 199-276/315.0
QVIDDVI-HRQQKIggGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVID
..|  |  |.....  |..|||||. | |.| .....  |.| .|| ..||... . .|. . ..| ..|||  |||.. 
nlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 885-970 2.8e-16 54.5 In-house 199-284 (297) alignment 
Range on Protein: 885-970
Range on HMM: 199-284/297.0
HTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYF
...|..|..| .  ..   ||..|||.  | | ||....   . . | |  ||.|.. | .|...|  | | |||. .| ..  ..
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_PTPN6_pd Subfamily PTPN6 878-974 6.8e-16 53.1 In-house 199-301 (306) alignment 
Range on Protein: 878-974
Range on HMM: 199-301/306.0
NGIVREPHTILQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFK
.|. ..| ..|. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | .|. . | | | .||  .| .| .| .
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

LHS
 ..
tkk
0041856 (Phosphotyrosine protein) phosphatases II 834-971 9.5e-16 53.4 In-house 1-172 (182) alignment 
Range on Protein: 834-971
Range on HMM: 1-172/182.0
NKPFNRFKNITVYDDNRiilatnpnldmcQREYINASYVDGYSSN-------------------------------------------------------
|.. ||...|  || .|               ||||....|.  .                                                       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwp

--GIVRePHTILQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGvVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFK
  |.   ....|. |..|..      ||||.||||  |.|.|...   . ...    | |..... | .|. .||.|.|..||  ..... ....
Dhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 878-974 1e-15 52.4 In-house 186-281 (315) alignment 
Range on Protein: 878-974
Range on HMM: 186-281/315.0
NGIVREPHTILQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHS
.|. ..  ..|..| .|    ..    ...||||  | |.|| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||..  ... . 
kGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 878-972 1.1e-15 51.8 In-house 185-278 (515) alignment 
Range on Protein: 878-972
Range on HMM: 185-278/515.0
NGIVREPHTILQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKL
.|. ..  ..|..| .|   ....   |...|||  | | ||..|.   . . |   .||||.. . ||. .|  | | |||. ||...  ... 
kGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllw
0049772 (Phosphotyrosine protein) phosphatases II 813-971 1.4e-15 53.3 In-house 25-281 (314) alignment 
Range on Protein: 813-971
Range on HMM: 25-281/314.0
LNTHSLKSGEEKPCTIGYSEENKPFNRFKNITVYDdNRIILatnPNLDMCQREYINASYVDGYsSNGIVREPHT--------------------------
||..||    |. ..... ..|.  ||...|  .| || ||   |.|..    |||||||||.  . |. . ..                          
lnrrslsvlpeltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdl

---------------------------------------------------------------------------ILQVIDDV---IHRQqkIGGGPVVV
                                                                           .|. .|..   |..     ||||.|
nvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellkeelydpelferlgikylripvpDgsaplledfdeflefieea..dkggpvlv

HCSDTVSRSGVYCSVSIALEQCkaeGVvDVFQVTKAIRRSKP-----GAVTTLEQYTSIYDVIDMYFK
||.. ..|.|... . . . ..   || .. .. . .|.  |     |.. .||||  |.... .|.|
HCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 818-877 3.8e-15 50.5 In-house 29-89 (290) alignment 
Range on Protein: 818-877
Range on HMM: 29-89/290.0
LKSGE-EKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDMCQREYINASYVDGYSS
|.||| |.  |.| ...||. |||.|| |||||||.|   ..   |. |||||.|..||. 
ldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 885-969 4e-15 50.8 In-house 198-287 (325) alignment 
Range on Protein: 885-969
Range on HMM: 198-287/325.0
HT---ILQVIDDVIHRQQK--IGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMY
 |   |||... |  | .    . .|..||||. | |.||. |.  ||..   |  ||.|.. | .|. .|  | | .||. ||. .  .
atlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
0051429 (Phosphotyrosine protein) phosphatases II 865-971 6.7e-15 51.0 In-house 5-226 (272) alignment 
Range on Protein: 865-971
Range on HMM: 5-226/272.0
EYINASYVDGYssNGIVREP--------------------------------------------------------------------------------
 ||||..|.||  .. |..                                                                                 
gyiNardvggy..grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

-----------------------------------HTILQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVD--------VFQV
                                   ...|.... . .      ||||.||||  ..|.|... . . |..  .| .||        ....
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

TKAIRRSKPGAVTTLEQYTSIYDVIDMYFK
 . .|.  |||| | |||  .|...  ...
veelraqrpgavqteeqylflyeallellr
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 896-966 1e-14 49.2 In-house 185-255 (267) alignment 
Range on Protein: 896-966
Range on HMM: 185-255/267.0
HRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
. | . |. |.||.||| | ||| .  .   ||. | |||.|.|.  . ||  ..| | |.|.|  |....
knqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
0036282 (Phosphotyrosine protein) phosphatases II 885-964 2.2e-14 49.0 In-house 87-164 (174) alignment 
Range on Protein: 885-964
Range on HMM: 87-164/174.0
HtILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKaEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYD
  .|.... | . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
i.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 881-972 2.7e-14 47.8 In-house 174-266 (270) alignment 
Range on Protein: 881-972
Range on HMM: 174-266/270.0
VREPHTILQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKL
. ... .|... .|  .....  ..|..||||. | |.|.   . ||..  . .. ||| .. ...|. ..  | . |||. .| .. .| . 
slstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPN12_pd Subfamily PTPN12 882-972 4.2e-14 47.1 In-house 187-279 (290) alignment 
Range on Protein: 882-972
Range on HMM: 187-279/290.0
REPHTILQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKL
. ....|..|..| ..|.     |.|||||  | | |. ... .. |. ||| .   .|||..   .|. .. .| | |||. .|  .  ... 
ssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 886-966 7.8e-14 46.4 In-house 196-275 (288) alignment 
Range on Protein: 886-966
Range on HMM: 196-275/288.0
TILQVIDDVIHrQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
 .|.... |   ...   ||..||||. | |.|.. ..  .... ..| ..||. . . .|....  | ||.||  ||.|.
pllellrqvkv.anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 881-965 1.8e-13 45.5 In-house 201-286 (319) alignment 
Range on Protein: 881-965
Range on HMM: 201-286/319.0
VREPHTILQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDV
   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
pdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 817-877 2.1e-13 45.1 In-house 30-87 (305) alignment 
Range on Protein: 817-877
Range on HMM: 30-87/305.0
SLKSGeEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVDGYSS
|| .  |... .| .|.||  ||.|.||..||.||||.....||  ...||||||||||..
slyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 879-966 2.1e-13 45.4 In-house 163-251 (284) alignment 
Range on Protein: 879-966
Range on HMM: 163-251/284.0
GIVREPHTILQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
|    |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  .
gvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_PTPRB_pd Subfamily PTPRB 879-969 2.4e-13 44.8 In-house 193-284 (293) alignment 
Range on Protein: 879-969
Range on HMM: 193-284/293.0
GIVREPHTILQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMY
|.  ...|.|. .  | ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .
gvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
subfamily_CG42327_pd Subfamily CG42327 902-971 4.7e-13 43.5 In-house 246-316 (319) alignment 
Range on Protein: 902-971
Range on HMM: 246-316/319.0
GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFK
  ||.|||||| | |.|.  .  ||... .     ||. |.   .|| .  || | |||  || |. .| |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
fn3 Fibronectin type III domain 408-494 2.8e-12 39.8 Pfam-A 1-82 (85) alignment 
Range on Protein: 408-494
Range on HMM: 1-82/85.0
SPVTSLSVSNVSTTGITVSWNIP-SSDNYVTYYTIFYTPSCPQLssVNETVSVGPHqsttTYSYTLAGLYSGMNYTITVRAGNVLGGS
|... ||||.|..| .|.||. | . .  .|.|.. | ..  .   .  ...| ..    |.|.|| ||  |..|...|.| |  |..
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprt....ttsvtltgLkpgteYefrVqavngageg
subfamily_PTPN9_pd Subfamily PTPN9 898-966 3.2e-12 41.1 In-house 218-286 (297) alignment 
Range on Protein: 898-966
Range on HMM: 218-286/297.0
QQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
. .. | |.|||||  . |.| .... |.|.. . .|.|||... | .|  .  .. | |||.  |  .
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
0043147 (Phosphotyrosine protein) phosphatases II 879-964 5.3e-12 41.3 In-house 76-155 (172) alignment 
Range on Protein: 879-964
Range on HMM: 76-155/172.0
GIVREPHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaeG-VvDVFQVTKAIRRSKPGAVTTLEQYTSIYD
. |  .  .|.... . .....  ||||.||||  |.|.|. .   . |        . ..... . .|. .||||.. .||  .|.
hgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyy
subfamily_PTPRD_pd Subfamily PTPRD 817-877 6.1e-12 39.9 In-house 31-89 (564) alignment 
Range on Protein: 817-877
Range on HMM: 31-89/564.0
SLKSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLdmCQREYINASYVDGYSS
....|.. ...    ..||. ||..||. || .|..| . ..    . .|||||..||| .
kieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 823-878 8e-12 39.7 In-house 36-85 (287) alignment 
Range on Protein: 823-878
Range on HMM: 36-85/287.0
EKPCTIGYSEENKPFNRFKNITVYDDNRIILAtnpnldMCQREYINASYVDGYSSN
|.  |.. ...||. ||...| |.|..|..|        .. .||||...|||...
edevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykek
0046846 (Phosphotyrosine protein) phosphatases II 886-970 1e-11 40.4 In-house 94-173 (176) alignment 
Range on Protein: 886-970
Range on HMM: 94-173/176.0
TILQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSialeQCKAEGVVDVFQVTKAIRRSKP-GAVTTLEQYTSIYDVIDMYF
 .|.... .  ....  ||||.||||  ..|.|...        .. |  ..|... . .|. .| |||.| |||  .|... ...
lllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
0049260 (Phosphotyrosine protein) phosphatases II 881-964 1.1e-11 40.1 In-house 67-144 (152) alignment 
Range on Protein: 881-964
Range on HMM: 67-144/152.0
VREPHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaeGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYD
| . . .|. . ..|.. ..  ||||.||||  |.|.|...   . |        |..... . .|. .||||.. .|.  .|.
vpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
fn3 Fibronectin type III domain 137-211 1.3e-11 37.7 Pfam-A 2-79 (85) alignment 
Range on Protein: 137-211
Range on HMM: 2-79/85.0
APSSLTEVSKTATTITVSWTALD--SSDADGYVVNVTSDTDT--VQTVQVEGSSNdTIVLNGLRELTTYSIIVRAYQQL
||. |.  . |.|..|.||.. .  ... .|| | . .....   ....|..... . .|.||.. |.|.. |.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_PTPN13_pd Subfamily PTPN13 879-966 1.5e-11 39.1 In-house 180-265 (273) alignment 
Range on Protein: 879-966
Range on HMM: 180-265/273.0
GIVREPHTILQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
|. ...  .||..  | . |.    ||.|||||  . |||.. .. ..|.  . .  .|| .. . .|. . | | | .||  .| .|
gvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 895-963 2e-11 38.5 In-house 165-233 (239) alignment 
Range on Protein: 895-963
Range on HMM: 165-233/239.0
IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIY
| ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||||  .|  | | |||  |.
itkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 895-963 2.1e-11 38.5 In-house 166-234 (239) alignment 
Range on Protein: 895-963
Range on HMM: 166-234/239.0
IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIY
| ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||||  .|  | | |||  |.
itkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_PTPN23_pd Subfamily PTPN23 877-966 2.8e-11 37.8 In-house 183-276 (288) alignment 
Range on Protein: 877-966
Range on HMM: 183-276/288.0
SNGIVREPHTILQVIDDVIH---RQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQC-KAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
. |.   |.|.||..| | .    .|.    |.|||||  | |.||.. |  |...  | .|..|. || . .|. .   | . ||.   |...
elGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 897-966 3.7e-11 37.1 In-house 206-275 (439) alignment 
Range on Protein: 897-966
Range on HMM: 206-275/439.0
RQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
 ..|   ||||||||  | |.|   .. ||||| |.|  ||.  . | .|. .   | .| ||  ||. .
andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 878-966 6.9e-11 36.8 In-house 146-235 (237) alignment 
Range on Protein: 878-966
Range on HMM: 146-235/237.0
NGIVREPHTILQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
.|. ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  ..|   .|  . | .||  |...|
rgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0048076 (Phosphotyrosine protein) phosphatases II 882-969 9e-11 37.1 In-house 62-142 (145) alignment 
Range on Protein: 882-969
Range on HMM: 62-142/145.0
REPHTILQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiALEQCKAEGvVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMY
  . ..|.... . . ...  ||||.||||  |.|.|...    |.  .. .| |..... . .|.  ||||.. .|.  .|... ..
dllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpgqlrflyefelel
0051082 (Phosphotyrosine protein) phosphatases II 865-965 9.9e-11 37.0 In-house 59-148 (151) alignment 
Range on Protein: 865-965
Range on HMM: 59-148/151.0
EYINASYVDGYSSNgivrePHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaegvVDVFQVTKAIRRSKPGAVTTLEQYTSIYD
|...  ..|    .       .... . ....  .. ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. 
evlhipildwpdpg.....lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

V
.
a
subfamily_PTPN14_pd Subfamily PTPN14 903-971 1.4e-10 35.6 In-house 229-297 (300) alignment 
Range on Protein: 903-971
Range on HMM: 229-297/300.0
GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFK
  ||.||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.|.  |.|
kPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 904-966 1.6e-10 35.0 In-house 170-232 (392) alignment 
Range on Protein: 904-966
Range on HMM: 170-232/392.0
GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
 |...|||  | |.||  |.   . ..|   .||||..   ||| .|  | | |||. ||  .
hpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 879-970 2.4e-10 35.0 In-house 184-276 (281) alignment 
Range on Protein: 879-970
Range on HMM: 184-276/281.0
GIVREPHTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYF
|.  ... .|.  ..| . ..|    |.|.|||  | |.|.| ..  ......||   .|| .| . .|...   | |. ||. .| ..  ..
GvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 819-877 3.9e-10 33.8 In-house 33-86 (95) alignment 
Range on Protein: 819-877
Range on HMM: 33-86/95.0
KSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDmcqreYINASYVDGYSS
      | |.| || | | ||| ||  ||  |..|.|. . |     |||| .||||. 
smtsgapytvgsseanipknrflnifpydatrvvlttkrdsd.....yinacfvdgyar
0044763 (Phosphotyrosine protein) phosphatases II 885-972 7.4e-10 34.2 In-house 92-173 (178) alignment 
Range on Protein: 885-972
Range on HMM: 92-173/178.0
HTILQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGVvDVFQVTKAIRRSKPgAVTTLEQYTSIYDVIDMYFKL
  ... . . |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . .|. .| .|.. .|.  .|..  ...| 
lehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrllke
0048179 (Phosphotyrosine protein) phosphatases II 883-964 7.5e-10 34.2 In-house 65-139 (144) alignment 
Range on Protein: 883-964
Range on HMM: 65-139/144.0
EPHTILQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIALeqckAEGvVDVFQVTKAIRRSKPGAVTTLEQYTSIYD
 .. .|.... . . ..   ||||.||||  |.|.|...   . .     .| ...... . .|.  ||||.. .|.  ...
llellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPN3_pd Subfamily PTPN3 878-966 7.8e-10 33.1 In-house 184-271 (280) alignment 
Range on Protein: 878-966
Range on HMM: 184-271/280.0
NGIVREPHTILQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
.|.  ... .|.... | .....    |||||||  . |.||.  . .||    |.  | . .. . .|  .   | | .||. . . |
hgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 903-965 2.2e-09 31.8 In-house 135-199 (199) alignment 
Range on Protein: 903-965
Range on HMM: 135-199/199.0
GGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDV
  ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
dapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 903-965 2.2e-09 31.8 In-house 134-198 (198) alignment 
Range on Protein: 903-965
Range on HMM: 134-198/198.0
GGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDV
  ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
dapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 823-877 2.3e-09 31.7 In-house 37-89 (319) alignment 
Range on Protein: 823-877
Range on HMM: 37-89/319.0
EKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNldMCQREYINASYVDGYSS
..  .    ||||. ||..||  ||  |..|.. ..  . . .|||||..|||  
ndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqe
DSPc_SM00195 817-877 3.5e-09 31.7 In-house 9-67 (263) alignment 
Range on Protein: 817-877
Range on HMM: 9-67/263.0
SLKSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLdmCQREYINASYVDGYSS
...| ..|..| .  ..||  ||.||| .||..|..| ....    . .||||.|..|...
leestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgank
PTPc_SM00194 817-877 3.5e-09 31.7 In-house 9-67 (263) alignment 
Range on Protein: 817-877
Range on HMM: 9-67/263.0
SLKSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLdmCQREYINASYVDGYSS
...| ..|..| .  ..||  ||.||| .||..|..| ....    . .||||.|..|...
leestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgank
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 819-877 3.7e-09 31.1 In-house 25-82 (281) alignment 
Range on Protein: 819-877
Range on HMM: 25-82/281.0
KS-GEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVDGYSS
.. | ... |  ...||.  ||..||. ||  |. .. | .    . .||||..|.||..
aaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvpgykg
subfamily_PTPRG_pd Subfamily PTPRG 823-877 3.8e-09 30.3 In-house 36-89 (563) alignment 
Range on Protein: 823-877
Range on HMM: 36-89/563.0
EKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDMCQrEYINASYVDGYSS
. ...    .|||  ||  ||. ||  |. |.  |. .    .||||.|.|||  
dldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 868-971 9.7e-09 29.8 In-house 161-260 (290) alignment 
Range on Protein: 868-971
Range on HMM: 161-260/290.0
NASYVDGYSSNGIVREPHTILQVIDDVIhrQQkigGGPVVVHCSDTVSRSGVYCSVSIALEQCK-AEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
. | . |...  . ... |.|..|. |   ..   . ||.||| | .||| .  .. ..       .| | . .| ||.|. .  |.|. .... .  .|
tHsllkgWnklnvqedtktllsliqkvk..as...ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi

DMYFK
 ....
vllai
subfamily_Ptp69D_pd Subfamily Ptp69D 823-876 1.1e-08 29.5 In-house 37-88 (307) alignment 
Range on Protein: 823-876
Range on HMM: 37-88/307.0
EKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVDGYS
.| ....  .||.  ||...|. .|..|..|.. .  .  . .|||||.. || 
dkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgyk
fn3 Fibronectin type III domain 606-697 1.5e-08 27.9 Pfam-A 8-84 (85) alignment 
Range on Protein: 606-697
Range on HMM: 8-84/85.0
VSSImDTTWAVISWSVPSyiPSDYPIITYEIGYHMLQSGNcsmvydddinlqVFNLSNVSSNDTFTIITRLNSNTCYIFGIRAYSDNGYGAW
||..  .| ...||| |.  . . ||  ||. | . ..|.            . .  .|... |  ..| |. .| | | ..|....|.| .
vsev.tstsltlsWsppk..dgggpitgYeveyrekggge............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_PTPN6_pd Subfamily PTPN6 827-875 2.8e-08 28.1 In-house 47-92 (306) alignment 
Range on Protein: 827-875
Range on HMM: 47-92/306.0
TIGYSEENKPFNRFKNITVYDDNRIILAtnpNLDMCQREYINASYVDGY
. |   |||  ||.|||  .|..|.||.   . .. . .||||.|... 
kegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikke
subfamily_PTPRB_pd Subfamily PTPRB 821-878 3.8e-08 27.7 In-house 38-93 (293) alignment 
Range on Protein: 821-878
Range on HMM: 38-93/293.0
GEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVDGYSSN
|... ...  ...|.  ||..||  || .|. ||.    |  . .||||.|..||.|.
gkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyipgynsp
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 905-966 4e-08 27.5 In-house 230-291 (297) alignment 
Range on Protein: 905-966
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||||.. .||..
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 893-973 4.6e-08 27.2 In-house 200-280 (287) alignment 
Range on Protein: 893-973
Range on HMM: 200-280/287.0
DVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLH
 .  ...  . ||.|||..  . |||.. .. . ... .  | ||| .|   .|  . . | .  |.  .|. .  |.|  
hielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 831-962 5.3e-08 26.7 In-house 158-280 (302) alignment 
Range on Protein: 831-962
Range on HMM: 158-280/302.0
SEENKPFNRFKNITVYDdnriILATNPNLDMCQREYINASYVDGYSSNGIVREPHTILQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIALEQC
 .. . |   |....|     .  .| .  . ..  ..  .  ..   |  .|..| |...      ...     |.||||  | |.|   ..   .. |
ktdleeftdkksfklyt....veiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlc

KAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSI
. . | |. .. . .|. . ||| . .| . .
skkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_PTPN1_pd Subfamily PTPN1 884-963 9.6e-08 26.1 In-house 181-264 (290) alignment 
Range on Protein: 884-963
Range on HMM: 181-264/290.0
PHTILQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKAIRRSKPGAVTTLEQYTSIY
| . |. . .| .    .   ||.|.|||  . ||| .| |   | . ....    ||. .|  ..|. . | . | .|    |
paaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 902-975 1e-07 25.7 In-house 217-290 (302) alignment 
Range on Protein: 902-975
Range on HMM: 217-290/302.0
GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFKLHST
.  ..|.     . | |.  .. .|.|. ...  . . .. |.||  .| || .|.||.|.| .. .|.| . |
adentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvt
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 907-968 1e-07 26.2 In-house 2-63 (69) alignment 
Range on Protein: 907-968
Range on HMM: 2-63/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDM
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| .  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
fn3 Fibronectin type III domain 525-589 1.1e-07 25.0 Pfam-A 18-85 (85) alignment 
Range on Protein: 525-589
Range on HMM: 18-85/85.0
LTWNEVNcsKHNGLITGYTVVISNS-----SITYTLTSTERYIILKVLAFGTEYNISVAAENSAGIGPFS
|.|.. .  . .| ||||.|  ...     . ..|...|..  .|. |  ||||...|.| | || ||.|
lsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 825-877 1.1e-07 26.2 In-house 24-70 (267) alignment 
Range on Protein: 825-877
Range on HMM: 24-70/267.0
PCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLdmcqreYINASYVDGYSS
 ..  ..|.|. .||. .   |||.|.|| |. .       |||||||.||  
tisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegykt
subfamily_PTPRN_pd Subfamily PTPRN 903-964 1.1e-07 25.9 In-house 224-286 (297) alignment 
Range on Protein: 903-964
Range on HMM: 224-286/297.0
GGPVVVHCSDTVSRSGVYCSVSIALEQC-KAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYD
  |.|||||| . |.|||. . . |..  |    .|.    . .|  .|| | | .|.  .. 
scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_PTPRA_pd Subfamily PTPRA 826-876 1.2e-07 26.0 In-house 50-98 (330) alignment 
Range on Protein: 826-876
Range on HMM: 50-98/330.0
CTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVDGYS
. .   ||||  ||. ||  || .|.||..    .  . .|||||..||| 
lelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGyk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 832-878 1.2e-07 26.1 In-house 44-88 (318) alignment 
Range on Protein: 832-878
Range on HMM: 44-88/318.0
EENKPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVDGYSSN
. ||  ||. ||. ||. |. | .    .  . .||||.|.||| ..
pvnkaknryanilaydhtrvkLqmle..geegsDyinanyidGyrrk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 815-877 1.7e-07 25.0 In-house 26-86 (392) alignment 
Range on Protein: 815-877
Range on HMM: 26-86/392.0
THSLKSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVDGYSS
 | | . .  | |..  | |.. ||.|||  || .|..|      |. ...|.||||.... .
fhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid..dipdsdylnasyipsfdn
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 822-876 1.9e-07 25.6 In-house 44-96 (298) alignment 
Range on Protein: 822-876
Range on HMM: 44-96/298.0
EEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVDGYS
||.  ... ..|||  ||. .|  .|  |..| ..   .  . .|||||....|.
eeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhayk
fn3 Fibronectin type III domain 324-389 2.4e-07 24.0 Pfam-A 3-76 (85) alignment 
Range on Protein: 324-389
Range on HMM: 3-76/85.0
PNDVKGFILNASSIKVNWTNS----IGTNGYVIEYTTGGVT--RNVVSTSEDE--VVLTNLSPMSTYTISVYSY
| ...    ...|. ..|. .        || .|| . | .   . .......  |.||.| | ..|...|...
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 903-966 2.4e-07 24.7 In-house 216-279 (290) alignment 
Range on Protein: 903-966
Range on HMM: 216-279/290.0
GGPVVVHCSDTVSRSGVYCSVSIALeQCKAEG-VVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVI
 ||||||||  . |.| . .. ..| |.  .|  .|. .. .|.|.|. ..|    ||  . ...
sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 907-971 3.5e-07 24.5 In-house 1-65 (69) alignment 
Range on Protein: 907-971
Range on HMM: 1-65/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFK
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| .   .|
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 824-877 4.3e-07 24.3 In-house 37-88 (288) alignment 
Range on Protein: 824-877
Range on HMM: 37-88/288.0
KPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVDGYSS
|  |.|   .|.. ||..||  || .|. |   .. .  . .||||||.||. .
ksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyidgekk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 895-966 5.2e-07 23.6 In-house 192-265 (281) alignment 
Range on Protein: 895-966
Range on HMM: 192-265/281.0
IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKAIRRS-KPGAVTTLEQYTSIYDVI
| |. .    | |.|||  | |||   .| |||.  ..   . |. |.   .| . .  .| ||.||  |. |.
ilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_PTPN12_pd Subfamily PTPN12 817-877 6.6e-07 23.5 In-house 23-81 (290) alignment 
Range on Protein: 817-877
Range on HMM: 23-81/290.0
SLKSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVDGYSS
 .|. .. . . | .|||.  ||.|.|  || .|. | .. . .  . .||||... | ..
kykaekvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgveg
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 815-877 7.8e-07 23.2 In-house 25-85 (315) alignment 
Range on Protein: 815-877
Range on HMM: 25-85/315.0
THSLKSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVDGYSS
 | |   .  . ...  ..| . ||.|||  .| .|..|      |  ...||||||. .. .
fhdlpdPdiyrqrvaretinfkknryknilPldsarvklevid..dsPdsdyinasyiksvdd
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 903-971 9.1e-07 23.2 In-house 209-278 (307) alignment 
Range on Protein: 903-971
Range on HMM: 209-278/307.0
GGPVVVHCSDTVSRSGVYCSVSIALEQ-CKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDVIDMYFK
  |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  .. |.  || 
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
Y_phosphatase Protein-tyrosine phosphatase 834-877 1.6e-06 23.1 Pfam-A 1-40 (235) alignment 
Range on Protein: 834-877
Range on HMM: 1-40/235.0
NKPFNRFKNITVYDDNRIILatnpN-----LDmcqreYINASYVDGYSS
||  ||.|.|..||..|. |    .      |     ||||.||.||..
nkkknRykdilpydktrvkl....kgsegpsd.....YInAnyvkgyke
Y_phosphatase Protein-tyrosine phosphatase 834-877 1.6e-06 23.1 In-house 1-40 (235) alignment 
Range on Protein: 834-877
Range on HMM: 1-40/235.0
NKPFNRFKNITVYDDNRIILatnpN-----LDmcqreYINASYVDGYSS
||  ||.|.|..||..|. |    .      |     ||||.||.||..
nkkknRykdilpydktrvkl....kgsegpsd.....YInAnyvkgyke
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 817-876 3.5e-06 20.4 In-house 26-83 (515) alignment 
Range on Protein: 817-876
Range on HMM: 26-83/515.0
SLKSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVDGYS
 |   .  | |.   | | . ||.|||  || .|..|      |  . .|.||||. .. 
dlpgpniypqtvaqeeinfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfd
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 822-873 4.3e-06 20.8 In-house 21-66 (283) alignment 
Range on Protein: 822-873
Range on HMM: 21-66/283.0
EEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNldmcqrEYINASYVD
 .....|  ..|||..||...| ..| .|. | ....      .||||... 
pdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfip
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 901-970 5.4e-06 20.2 In-house 221-289 (310) alignment 
Range on Protein: 901-970
Range on HMM: 221-289/310.0
IGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKAIRRSKPGAVTTLEQYTSIYDvIDMYF
.  ||.|||||  . | .| ... ..... .    ||. .|   ...|.   . |  ||. |   . . |
vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr.vriif
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 816-877 6.4e-06 20.3 In-house 31-90 (315) alignment 
Range on Protein: 816-877
Range on HMM: 31-90/315.0
HSLKSGEEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLDmcQREYINASYVDGYSS
 |.  |. .|  .    |||  ||. ||  ||  |. |    | .  . .|.||...|||. 
esipggqlhpldvakkienkqknryiniiaydksrvqlpllendp..hsdyvnanfidGynk
subfamily_PTPN14_pd Subfamily PTPN14 822-873 6.7e-06 20.3 In-house 37-85 (300) alignment 
Range on Protein: 822-873
Range on HMM: 37-85/300.0
EEKPCTIGYSEENKPFNRFKNITVYDDNRIILATNPNLdmcQREYINASYVD
|.  .. .  .||.. ||||..  |.|||. |... .    . .||||| . 
edallstaklpenaeknrfkdvlPyednrvelsptken...stgyinassik
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 832-878 7.4e-06 20.5 In-house 59-103 (319) alignment 
Range on Protein: 832-878
Range on HMM: 59-103/319.0
EENKPFNRFKNITVYDDNRIILATNpnLDMCQREYINASYVDGYSSN
..||  ||. ||  .| |.. |       .   .|||||.|.|| ..
dqnkdknriinilafdknvvklerl..iGeefsdyinasfvtGyqrk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 831-877 8.4e-06 20.2 In-house 6-50 (250) alignment 
Range on Protein: 831-877
Range on HMM: 6-50/250.0
SEENKPFNRFKNITVYDDNRIILATNPNLDMCqrEYINASYVDGYSS
  .||  ||. .|  .|  |..| ..   . .  .|||||...||. 
kpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyde
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 827-874 8.5e-06 20.1 In-house 41-86 (325) alignment 
Range on Protein: 827-874
Range on HMM: 41-86/325.0
TIGYSEENKPFNRFKNITVYDDNRIILATNPnlDMCQREYINASYVDG
..    |||  |||||.  .| .|..| |    |  . .||||||.  
kvamkpenkaknrfknvvaldksrvvletkk..ddpssdyinasylrd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 832-878 9.7e-06 20.3 In-house 23-67 (284) alignment 
Range on Protein: 832-878
Range on HMM: 23-67/284.0
EENKPFNRFKNITVYDDNRIILATNpnLDMCQREYINASYVDGYSSN
..||  ||. .|  .| |.. |       .   .|||||.. || ..
dqnkdknrighilafdknvvklerl..iGeefsdyinasfitGyqrk