Gene PTPRD-57 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP114_AA protein Get Run
AqueP114_AA_890-1116 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 925-1123 3e-106 349.5 In-house 80-301 (301) alignment 
Range on Protein: 925-1123
Range on HMM: 80-301/301.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGRKYDEYGLEVTNEINS---------------------NGYTERMF
||.||..||.||.||..|..|||..|...|...|||.......    |. || .... .|.  ..|.....                     |||.||.|
gysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkf

KVSSDKeaISRNVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVT
||.|||   |..||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
kvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVt

TLEQYTSIYDVIDMYLQMNSMYGN
|||||||||||||||||.||.|.|
TLeqytsiydvidmylqlnstyan
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 925-1118 9.7e-79 259.7 In-house 84-286 (305) alignment 
Range on Protein: 925-1118
Range on HMM: 84-286/305.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC----GEEDCCFPYWLSGR----KYDEYGLEVTNEINSNGYTERMFKVSS-DKEAISRNVLQL
||..| ..|.||.|..|||.|||..|...||| ||||.    |..|.|  ||        ...|. .|...| . ..|.|| .|.|  |..  ||.|||.
gykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqy

QVADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|. |||..||.... ..|..|..| ..|.|  | |..||||..|.|.||...|.| ||..|.|.|||||.|.|..|......|.||.||....|..| ..
qltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli

QMN
.  
tcg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 925-1124 1.4e-63 209.5 In-house 81-287 (287) alignment 
Range on Protein: 925-1124
Range on HMM: 81-287/287.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSGR--KYDEYGLEVTNEINSNGYTERMFKVSSDK-EAISRNVLQLQV
||.||.|||||.||| ||.|.|||.| | .|.||||||     .|. |. || ...   . || .|..||  ..||.|| ..|  .. ..  ..| | |.
gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqi

ADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
..|.. | | ||.|.| ||.. .. |.| | ...|||||||| ||...|.. .....|| |||.||||| |  |  |||.| | |||. |.|.. .||. 
tnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

NSMYGNF
 ..| .|
fetysdf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 925-1120 1.9e-62 205.8 In-house 86-288 (290) alignment 
Range on Protein: 925-1120
Range on HMM: 86-288/290.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSG--RKYDEYGLEVTNEINSNGYTERMFKVSSDKE-AISRNVLQLQV
||.||...|..|.|..||..||||.| . ||..||||.     ... |  || .   ..|.|. ....|| . |.|.|| ..| .... . ...| |.|.
gykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqi

ADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
  |...| | .| |.|.||  ... | | | ...||||||||.||.|.|.. .....|| |||.||||| |  |  ||| |.| .||  |....  ||. 
tnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

NSM
 . 
fet
0050432 (Phosphotyrosine protein) phosphatases II 893-1120 3.7e-54 179.5 In-house 31-304 (308) alignment 
Range on Protein: 893-1120
Range on HMM: 31-304/308.0
LGTHVASyhSDTNAAFNQQYQGLYTGDDLRS----------------------------------------TGY--REKRAFIIAQSPMENTVRDFWKMI
|  .. .   . .  ...... |.   .|..                                        .||  . .|.||..|.|..||| |||.|.
llkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmv

LDYKVSAIVMLCGEEDC----CFPYWLSG-----RKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQDGVVREPRTVLQVIDDVIH
 ...|. ||||. ...     |..|| .      ..|. . .....| . ..|| | ....  ..  || | ...  .|| .||  .|. .|. .. | .
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrk

RQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNSM
..   .|||.|||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|.|||  .|... .||.   .
sl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0051299 (Phosphotyrosine protein) phosphatases II 886-1115 6.1e-53 175.5 In-house 3-286 (288) alignment 
Range on Protein: 886-1115
Range on HMM: 3-286/288.0
CPVSISDLGTHVASYHSDTNAAFNQQYQGLYTGDDLRS---------------------------------------------TGYREKRAFIIAQSPME
 ..|...|  .|  .. . .. . .... |.     ..                                             .||. ||.||..| |..
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

NTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSgR---KYDEYGLEVTNEINSNGYTERMFKVSSD----KEAISRNVLQLQVADWPQDGVVREP
||| |||.|. ...|. ||||.....     |..|| . .   .|...  . ..|   ..|| | ..|.      ..  ||.| .... .|| .||   |
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

RTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
. .|. . .|.. ..  ||||||||||. |.|.|... . . ||| ..||.|||... | .|. .||.|.|.|||  .|... .||
ellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 925-1119 7.9e-53 174.6 In-house 94-294 (298) alignment 
Range on Protein: 925-1119
Range on HMM: 94-294/298.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVA
.|... |||..| |...|| |||.|. ......||||   |.     .  || .   ..|.|  ... .. .   .. | .|||. ||. .|.| ||.. 
aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhft

DWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
 ||. || .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  .|.  
sWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf

S
.
n
0036941 (Phosphotyrosine protein) phosphatases II 900-1117 1.5e-52 174.1 In-house 7-279 (297) alignment 
Range on Protein: 900-1117
Range on HMM: 7-279/297.0
YHSDTNAAFNQQYQGLYTGDDLRS-----------------------------------------TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAI
 ... .| . .... |.    | |                                         .||. ||.||..| |..||| |||.|.....|. |
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMLCGEEDC----CFPYWL----SGRKYDEYGLEVTNEIN--SNGYTERMFKVSSDKEAISRNVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKI-G
|||. ...     |..||     .  .|... ......    ...|| | ..|.  ..  || | .... .|| .||   |...|. |. | ...... .
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

GGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
||||.||||. |.|||... . . |.| .    || ||.... | .|. .||||.|||||  .|... ..|. 
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0046845 (Phosphotyrosine protein) phosphatases II 924-1119 6.1e-52 172.1 In-house 66-278 (284) alignment 
Range on Protein: 924-1119
Range on HMM: 66-278/284.0
TGY-----REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGR---KYDEYGLEVTNEINSNGYTERMFKVSSDK-EAISR
.||     . |..||..| |..||| |||.|.....|. ||||.....     |..|| .     .|...  ....| . ..|| |.....  . .  ||
dgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesr

NVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQK-IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTS
 | .... .|| .||  .|. .|. ...| . ...  ||||.|||||. |.|.|... . . ||| ..||   .|||... | .|. .||.|.|||||  
tvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrf

IYDVIDMYLQMNS
.|... .||..  
vyealleylklkl
subfamily_PTPRD_pd Subfamily PTPRD 925-1118 1.1e-51 171.2 In-house 86-284 (564) alignment 
Range on Protein: 925-1118
Range on HMM: 86-284/564.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE----DCCFPYWLSG--RKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVA
|||...|.| .| |...|..|||.|. ....| ||||   |    . |  || .    .|.|.  ....| . . |. | ||..  |.  ||.| | .  
gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFt

DWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
.||. ||  .....|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | | |||  |...|  .|.. 
sWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
0047943 (Phosphotyrosine protein) phosphatases II 924-1115 2e-51 170.5 In-house 71-272 (273) alignment 
Range on Protein: 924-1115
Range on HMM: 71-272/273.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGR-----KYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQ
.||. ||.||..| |..||| |||.|. ...|. ||||. ...     |..|| .       .|...  ....| . ..|| | ..... .   || | .
dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvth

LQVADWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
... .|| .||   .  .|. |..| . .... ..||||||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|.|||  .|... .
fhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

YL
||
yl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 925-1121 1.1e-50 167.1 In-house 47-248 (250) alignment 
Range on Protein: 925-1121
Range on HMM: 47-248/250.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG---EEDCCFPYWL--SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVAD
||.|..|||..|.|...|. |||.|.|..|...||||     .|  .  ||     .|| .  ... .. .   || | .|.|. |.| .| | ||.   
gyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvv

WPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNS
||  || .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | | |||||.| |..|. .|.||..|||| ..| .|  .|.  .
WPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve

MY
 |
dy
0045450 (Phosphotyrosine protein) phosphatases II 883-1115 2e-50 167.6 In-house 4-304 (307) alignment 
Range on Protein: 883-1115
Range on HMM: 4-304/307.0
PKTCPVSISDLGTHVASYHSDTNAAFNQQYQGLYTGDDLRS--------------------------------------------------------TGY
|  ..... .|  .|.  . | .. . .... |.   .  .                                                         ||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGR---KYDEYGLEVTNEINSNGYTERMFKVSSD-KEAISRNVLQLQVA
. ||.||..|.|...|| |||.|. ...|..||||......    |..|| . .    |...  ....|   .||| | ..|.   ..  || | ...  
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

DWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
.|| .||   . ..|. |. | . ...  .||||.||||. |.|.|...   . |.| ..||.   ||.... | .|. .||||...|||  .|... ..
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

L
|
l
0039614 (Phosphotyrosine protein) phosphatases II 879-1117 2.4e-50 167.1 In-house 5-291 (297) alignment 
Range on Protein: 879-1117
Range on HMM: 5-291/297.0
DPLIPKTCPVSISDLGTHVASYHSDTNAAFNQQYQGLYTGDDLRS--------------------------------------------TGYRE-KRAFI
 . . ...|...| |  ..  .. . .  . .... |.   . .|                                            .||.  .|.||
rdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfI

IAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC---CFPYW--LSGrKYDEYGLEVTNEINSNGYTERMFKVSSDKEAisRNVLQLQVADWPQDGVVRE
..| |...|| |||.|. ...|..||||. ....   |..||   .| .|...  ......  .||| | ..|. ..|   | | ..|. .|| .||   
atqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgvpps

PRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
....|.... | .....  .||||.||||. |.|.|...   . |||.. || |||... | .|. .||||.|..||  .||.. ..|. 
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0040438 (Phosphotyrosine protein) phosphatases II 924-1119 5.1e-50 165.9 In-house 80-280 (317) alignment 
Range on Protein: 924-1119
Range on HMM: 80-280/317.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSgR---KYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQ
.|...||.||..|.|..||| |||.|. ...|. ||||. .|..    |..|| . .   .|...  ....|.  .|.| | ..|. ...  || | ...
dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfh

VADWPQDGVVREPRTVLQVIDDVIHRQQkiG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  .|| .||   |...|. .. | . ..  . ||||.||||. |.|.|... . . |||.. || |||... | .|. .||||.|.|||  .||.. .||
ytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

QMNS
. . 
krkl
Y_phosphatase Protein-tyrosine phosphatase 924-1111 1.1e-49 164.3 Pfam-A 36-233 (235) alignment 
Range on Protein: 924-1111
Range on HMM: 36-233/235.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWL----SGRKYDEYGLEVT-NEI-NSNGYTERMFKVSSDKEAI-SRNV
.||.||..||..| |...|. |||.|....||..||||. .|.     | .||        .|... .|.. .|  ....|| | ......||   .| |
kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrev

LQLQVADWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||.. .||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 924-1111 1.1e-49 164.3 In-house 36-233 (235) alignment 
Range on Protein: 924-1111
Range on HMM: 36-233/235.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWL----SGRKYDEYGLEVT-NEI-NSNGYTERMFKVSSDKEAI-SRNV
.||.||..||..| |...|. |||.|....||..||||. .|.     | .||        .|... .|.. .|  ....|| | ......||   .| |
kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrev

LQLQVADWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||.. .||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
DSPc_SM00195 925-1115 1.8e-49 163.8 In-house 64-262 (263) alignment 
Range on Protein: 925-1115
Range on HMM: 64-262/263.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSG----RKYDEYGLEVTNEINSN-GYTERMFKVSSDKEAISRNVLQL
|...|...|..| |...||.|||.|... ||. ||||. ||..    |  || .      ..... ........ .  .. | .... ...  .|.| |.
gankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy

QVADWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|. .||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
qyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 925-1115 1.8e-49 163.8 In-house 64-262 (263) alignment 
Range on Protein: 925-1115
Range on HMM: 64-262/263.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSG----RKYDEYGLEVTNEINSN-GYTERMFKVSSDKEAISRNVLQL
|...|...|..| |...||.|||.|... ||. ||||. ||..    |  || .      ..... ........ .  .. | .... ...  .|.| |.
gankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy

QVADWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|. .||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
qyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 925-1121 5.7e-49 161.9 In-house 84-286 (318) alignment 
Range on Protein: 925-1121
Range on HMM: 84-286/318.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVA
|||.|.|.| ||.|. .|..|||.|. . . . ||||  ||.     .  || |   |.|..   |...|.... |. | |||. ..|  ||.| | ...
GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhyt

DWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
.||. ||  .. ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | .||. ||||.  .|.  
sWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg

SMY
 ..
dte
0043336 (Phosphotyrosine protein) phosphatases II 888-1115 3.1e-48 160.0 In-house 2-277 (278) alignment 
Range on Protein: 888-1115
Range on HMM: 2-277/278.0
VSISDLGTHVASYHSDTNAAFNQQYQGLYTGDDlR-S--------------------------------------------TGYREKRAFIIAQSPMENT
.|..||  ... .. . .... .... |.. .                                                 .||. .|.||..| |...|
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

VRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLsG--RKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQDGVVREPRTVLQVI
| |||.|. ...|. ||||.....     |..||  |   .|...  ....|.  ..|| | ..|.  ..  || |....  .|| .||   . ..|. .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

DDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 .|.....   .|||.||||. |.|.|... . . ||| . || ||.... | .|. .||||.|..||  .|... .||
kavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 925-1118 4.5e-47 155.7 In-house 86-286 (319) alignment 
Range on Protein: 925-1118
Range on HMM: 86-286/319.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSGR--KYDEYGLEVTNEINSNGYTERMFKVSSDKEAI-SRNVLQLQV
||.|...|| .|.|.|||. |||.|. ....| .|||..  .     .  || .    .| .. ... .| . ..|  | .|.   .. . .|.| . | 
gyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqy

ADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
 .||...| .. ...|... .. . ..|   ||.|||||. | | | .. ... ||. | |||.|||.. . .|  ..  | . |||. ||...  ....
teWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea

N
 
g
0040439 (Phosphotyrosine protein) phosphatases II 923-1115 1.1e-46 154.9 In-house 47-246 (249) alignment 
Range on Protein: 923-1115
Range on HMM: 47-246/249.0
STGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQ
 .||. ||.||..| |...|| |||.|. ......||||. .. .    |..|| .    .|...  ...... ...|| |.....  ..  || ||..|
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

VADWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
. ||| .||   . ..|. |. | . ....  ||||.||||. |.|.|...   . ||| . |. ||.... | .|. .||||...|||  .|... ..|
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 924-1115 2.3e-44 147.0 In-house 46-243 (245) alignment 
Range on Protein: 924-1115
Range on HMM: 46-243/245.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSgR---KYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQ
.||| .. ||..| |...|| |||.|. ......||||. ||.     |..|| . .   .|...  ....| . ..|| | ..|. ...  ||.|....
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

VADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  .|| .||   ....|.... | . ... ..|||.||||. |.|.|... . . ||| ..|. |..... | .|. .||||.|..||  .|... ..|
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPRA_pd Subfamily PTPRA 924-1119 6e-44 145.3 In-house 95-300 (330) alignment 
Range on Protein: 924-1119
Range on HMM: 95-300/330.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSG--RKYDEYGLEVTNEINSNGYTERMFKVS----SDKEAISRNVL
 ||.||  || || | |.|| |||.|| ..| ..||||      .|. |  || .     | .  .|| .|  .. || | | |     . .|  || | 
dGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvr

QLQVADWPQDGVVREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
|.    ||. ||  ||. .|...  | . .|. .| |.|||||  | |.| .. ..  ||. |||..||||.. | .|  .|  | |.|||. || |.  
qfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

Y-LQMNS
| |  ..
yylygdt
subfamily_Ptp69D_pd Subfamily Ptp69D 924-1114 1.2e-42 141.1 In-house 85-285 (307) alignment 
Range on Protein: 924-1114
Range on HMM: 85-285/307.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWL--SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAI-----SRNV
 ||.||. ||.|| |.|.|. |||.|| . .|  ||||  ...     |  ||      .|..   .. .| . . |..| ..||  ||       ||.|
kgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkv

LQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
.| .   |.   | . .|..|..|. | . ...   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  . 
vqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyrall

MY
 |
dy
0045098 (Phosphotyrosine protein) phosphatases II 925-1117 1.7e-42 141.2 In-house 61-274 (278) alignment 
Range on Protein: 925-1117
Range on HMM: 61-274/278.0
GYreKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGR--KYDEYGLEVTNEINSNGYTERMFKVSSD----KEAISRNVLQ
||  ...||..| |...|| |||.|. ......||||.....     |..|| .|    |... .....| . . || |...|       ..  ||.| .
gy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvth

LQVADWPQDGVVREP--RTVLQVIDDVIHRQQK------------IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVRRSKPG-AVT
|.   ||  ||  .|  . .|.... . .....             .||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||.
lhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavq

TLEQYTSIYDVIDMYLQM
.||||  .|... ..|..
nleqyrflyefllelllr
subfamily_PTPRK_pd Subfamily PTPRK 924-1111 3.6e-41 136.0 In-house 80-273 (314) alignment 
Range on Protein: 924-1111
Range on HMM: 80-273/314.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG-EED---CCFPYWL-SGRKYDEYGLEVTNEINSNGYTERMFKVSS--DKEAISRNVLQLQ
 .|.  .|||..| |...||.|||....|.. ..||||    |     |  ||   ...|..  .|. .    . .  |.|.|.    .    | | |.|
dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfq

VADWPQDGVVREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
   ||. .|  . ...|...  | . |.. . |..|||||    |.|... ..| |.  . |||||||.. |..| .|.  | | |||. |||||
flgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 923-1111 8.2e-40 131.5 In-house 68-262 (283) alignment 
Range on Protein: 923-1111
Range on HMM: 68-262/283.0
STGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC----GEEDCCFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRN-VLQL
|  |.... .||||||...||.|||||. | |..|||||     ...  |  || .    .| |. . . .|  || .. . . .  .  | |   .   
sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahy

QVADWpqdgVVREPRTVLQV---IDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|| ||    .  .. ...     .. ||  |..   ||.||||| .. |..|....|  ... ..| |||||.| | .|  ...|| ||.||  .....
qvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0037934 (Phosphotyrosine protein) phosphatases II 929-1114 1.9e-39 131.0 In-house 44-241 (243) alignment 
Range on Protein: 929-1114
Range on HMM: 44-241/243.0
KRaFIIAQSPMENTVRD----FWKMILDYKVSAIVMLCGEE----DCCFPYWLSGRKYDEYGLEVTNEINSNGYTERMFKVSSDK-EAISRNVLQLQVAD
.| .|. | |...|| |    ||.|. ......||||. ..      |..|| ..  |...  ....| . ..|| |.....  . .  .|.| ...   
pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylp

WPQDGVVREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGvVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVI
||  ||  .|  .|. .|.|.  ...        .||||.||||  |.|.|...   . |...   | ||.... | .|. .|| ||.|..||  .|...
wpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeal

DMY
 ..
lel
subfamily_PTPN6_pd Subfamily PTPN6 928-1119 6.4e-39 128.7 In-house 96-301 (306) alignment 
Range on Protein: 928-1119
Range on HMM: 96-301/306.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSGRKYDEYG---LEVTNEINSNGYTERMFKVS-SDKEAISRNVLQLQVAD
.....| .|  .|.|| |||.|... .   |||.  | .     | .|| .  . .|||   .. ..| . . |. | ..||  .|.  .|.| |..  .
sdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfks

WPQDGVVREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
||. || ..| .||. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | | .||  .| .| .
WPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

YLQMNS
|.. ..
yietkk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 924-1110 2.8e-38 127.0 In-house 98-286 (319) alignment 
Range on Protein: 924-1110
Range on HMM: 98-286/319.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCgeEDCCFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSS-DKEAISRNVLQLQVADW
|||. |  .| || |..||. |||.|| .|..|.||.|   .| |  ||      |.... ..|.   ... |. | ...|   ||   |.. |     |
tGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGw

PQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
|. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
pdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 924-1110 4.4e-38 126.4 In-house 62-250 (284) alignment 
Range on Protein: 924-1110
Range on HMM: 62-250/284.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCgeEDCCFPYWLS--GRKYDEYGLEVTNEINSNGYTERMFKVSS-DKEAISRNVLQLQVADW
|||. |  .| .| |..||. |||.|| .|..|.||.|   .| |  ||      |.... ..|.   .|. |. | ...|   ||   |.. |     |
tGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgw

PQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
|. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
pdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 924-1111 9.3e-38 124.9 In-house 86-275 (315) alignment 
Range on Protein: 924-1111
Range on HMM: 86-275/315.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC----GEEDCCFPYWLSGR-KYDEYGLEVTNEINSNGYTERMFKVSSDKEaIsRNVLQLQVA
 ||  || .| ||.|  ..|.|||... ..... ||||     ||.  .  ||   .  | .. .   .|   . || | . | .... | |.|.||...
dGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgdn.i.revvqlhyt

DWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||. || .   .....|  |   ...   |..|||||. | |.| .....  |.| .|| ..||... . ||. . ..| ..|||  |||..
swpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 929-1118 1.4e-37 124.5 In-house 91-287 (297) alignment 
Range on Protein: 929-1118
Range on HMM: 91-287/297.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE---DCCFPYWLSGRK--YDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQD
|  .|  | ||..|| |||.|.||..||.||||  ..   . |  ||       . .  ....   . .|. .| ..|. .|    | | | |  .||..
khrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdk

GVVR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
 | |  . ...|..|..| .  ..   ||..|||.  | | ||....   . . | |  ||.|.. | .|...|  | | |||. .| ..  .|  .
averkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_CG7180_pd Subfamily CG7180 925-1117 1.6e-37 123.7 In-house 80-292 (296) alignment 
Range on Protein: 925-1117
Range on HMM: 80-292/296.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC---CFPYWLSG--RKYDEYGLEVTNEINSNGYTERMFKVSSD----------KEAIS
..  |...|. . |...|| .||... | ..||.|.|. . |    .  ||      .| |  .|...| .    . |.||.              .|  
sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaet

RNVLQLQVADWPQ-DGVVREPRTVLQVIDDVIHRQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
| |...|.  |.  | |     ......  |   ..|.      |||||..|| .||||||... . ||. . |. ||||.  | .|||.|. | . |.|
RivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeY

TSIYDVIDMYLQM
  ||||.  .. .
kyiYdvlleavlc
subfamily_PTPRG_pd Subfamily PTPRG 924-1112 1.3e-36 120.9 In-house 85-284 (563) alignment 
Range on Protein: 924-1112
Range on HMM: 85-284/563.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSGR--KYDEYGLEVTNEINSNGYTERMFKVSS-----DKE-AISRN
 ||. ..|||..| |...|. |||.|| . .|. |||.      .   |. || .    .|..  .  ..|     ||.| ...        |.    ..
dGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdtekl

VLQLQVADWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
| | . ..||. ||   .  ||. .     . .|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |||. ..|..
vrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal

D
 
l
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 926-1117 2.3e-36 120.3 In-house 68-270 (274) alignment 
Range on Protein: 926-1117
Range on HMM: 68-270/274.0
Y-REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--EE--DCCFPYWLSGRKY------DEYGLEVTNEINSNGYTERMFKVSSDKEaiSRNVLQ
| .|..|.. .| |. ||| |||.||   .|. ||||    |.  . |  |.   ..|      ..  ..|.. .. |.|. | . ... ..  .|.|  
ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkh

LQVADWPQDGVVREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
   .|||   . ....|.|.....| . ...     .|||||||  . | |.. ..||.. | ..|.||||....  .|  . | | | |||  |. .. 
ywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

MYLQM
.||. 
lylkr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 925-1112 2.4e-35 117.0 In-house 85-276 (288) alignment 
Range on Protein: 925-1112
Range on HMM: 85-276/288.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSGRKYDEYG---LEVTNEINSNGYTERMFKVSsdKEAISRNVLQLQV
|...|...| .|.|. .|| |||... ..|.| |||| .    ..  |  || .. |  .||   ...... . . ...| . .   |.   ... |.| 
gekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqy

ADWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
  ||..|| .  . .|.... |   .|.   ||..||||. | |.|.. ..   ... ..| ..||. . . .|....  | ||.||  ||.|. 
laWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN12_pd Subfamily PTPN12 927-1116 5.4e-35 115.7 In-house 80-278 (290) alignment 
Range on Protein: 927-1116
Range on HMM: 80-278/290.0
REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE----DCCFPYWLSGRK----YDEYGLEVTNEIN-SNGYTERMFKVSSDKEaiSRNVLQLQV
 .| ..| ||.|. .|. |||.|| ...|. .||.| |       |  || .  .    ..|. .....| . ..... |..||  .||  ||.| |.. 
egkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqke..srkvyqfhY

ADWPQDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
 .||  || . . ..|..|..| ..|.     |.|||||  | | |. ... .  |. ||| .   .|||..   .|. .. .| | |||. .|  .  .
taWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

LQ
.|
vq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 926-1117 1e-34 114.8 In-house 83-279 (315) alignment 
Range on Protein: 926-1117
Range on HMM: 83-279/315.0
YREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--EEDC--CFPYWLS----GRKYDEYGLEVTNEINSNGYTERMFkvSSDKEAISRNVLQLQV
. . .|.| .| | . .| |||.|.|..||..|||.    |.|   |  ||        .. .. .|. .     . . | .     |   ||.| | | 
vdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqf

ADWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
 .||. || ..  ..|..| .|    ..    ...||||  | |.|| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||..  .|. 
tewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllw
subfamily_PTPRB_pd Subfamily PTPRB 925-1116 2.2e-34 113.8 In-house 89-286 (293) alignment 
Range on Protein: 925-1116
Range on HMM: 89-286/293.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC--GE--EDCCFPYWLSGRKYDEYG---LEVTNEINSNGYTERMFKVSSdkEAISRNVLQLQV
||. .| || .| |. .|| |||.|... |.|.||||    |     |  || . ..   ||   .....| . . .. | .|..   |  .|.| |.. 
gynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhf

ADWPQDGVVREPRTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
  ||. ||  ...|.|. .  | ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .|.
tsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 927-1116 4.6e-34 112.4 In-house 83-277 (515) alignment 
Range on Protein: 927-1116
Range on HMM: 83-277/515.0
REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE----DCCFPYWLS----GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEaiSRNVLQLQVA
   .|.| .| | . .| |||...|...|..|.|.   .      |  ||        |. .. .|.       | . | ..|  ...  || | | .  
dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhft

DWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.||. || .. ...|..| .|   ....   |...|||  | | ||..|.   . . |   .||||.. . .|. .|  | | |||. ||...  .| 
eWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 926-1114 5.8e-33 109.4 In-house 87-287 (325) alignment 
Range on Protein: 926-1114
Range on HMM: 87-287/325.0
YREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVML---CGEEDCCFPYWLSG-RKYDEY-GLEVT----NEInsNGYTERMFKVSSDKEAISRNVLQLQ
...|  |. ||.|. .|. |.|...||.. | .|.|    ...| |  ||     |  .. ||||     .||    |  |...|   |.  .| | |.|
dkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei..sdyvhrvldvkqvkkGetrsvkqfq

VADWPQDGVVREPRTVLQVIDDVIHRQQKI-----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.  |.. || . | |.. ... | . ....     . .|..||||. | |.||. |.   |..   |  ||.|.. | .|. .|  | | .||. ||. .
lqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal

DMY
  .
vea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 925-1116 6.4e-33 109.1 In-house 79-277 (281) alignment 
Range on Protein: 925-1116
Range on HMM: 79-277/281.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSGR---KYDEYGLEVTNEINSNGYTERMFKVsSDKEAISRNVLQLQV
||......|..|.|. ... .||.|....|||||||.  | .     |  ||  ..   || .. .. |.| ... | || ||. . ... .|.| ||. 
gykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlay

ADWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
  ||. ||  ... .|.  ..| . ..|    |.|.|||  | |.|.| ..   .....||   .|| .| . .|...   | |. ||. .| ..  .|.
taWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN9_pd Subfamily PTPN9 924-1114 2.5e-31 103.8 In-house 79-289 (297) alignment 
Range on Protein: 924-1114
Range on HMM: 79-289/297.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--E--EDCCFPYWL----SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQL
 ||..|.||| .| |...||.|||.|. . .|  |||     |     |  ||     |  .. .. ... .  ... |..|.....  |.  ||.|   
dGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthf

QVADWPQDGVVREPRTVLQVIDDVIHRQQ------------KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQ
|.  ||  || ..  ..|.|.. | ..|             .. | |.|||||  . |.| .... | |.. . .|.|||... | .|  .  .. | ||
qflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeq

YTSIYDVIDMY
|.  |  .  |
yefcylavley
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 927-1118 5.4e-31 102.6 In-house 61-267 (270) alignment 
Range on Protein: 927-1118
Range on HMM: 61-267/270.0
REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSGRK----YDEYGLEVTNEI--NSNGYTERMFKVSsdKEAISRNVLQLQ
 ||...| |..|...|...||.||.. ||.||||. |      . |  || . .|    . .  ..|...   ...||  .  ..   ... .|...  .
gekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfw

VADWPQDGVVREPR------TVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
  .||..||.||.        .|... .|  .....  ..|..||||. | |.|.   . |...  . .. ||| .. ...|. ..  | . |||. .| 
yntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflyk

VIDMYLQMN
.. .| .. 
avveyaerr
subfamily_PTPN23_pd Subfamily PTPN23 931-1112 1.2e-30 101.4 In-house 84-277 (288) alignment 
Range on Protein: 931-1112
Range on HMM: 84-277/288.0
AFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDCCFP----YWLS----GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQ
 ||..|.|...|. |||.|. . |.| ||||  .|.   |    || .      |.... . . .. ... . ||..|..  ..   ..|  ||.  ||.
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpe

DGVVREPRTVLQVIDDVIH---RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
 ||   | |.||..| | .    .|.    |.|||||  | |.||.. |   ...  | .|..|. || . .|. .   | . ||.   |... 
lGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
0051429 (Phosphotyrosine protein) phosphatases II 907-1115 3.2e-30 101.1 In-house 6-225 (272) alignment 
Range on Protein: 907-1115
Range on HMM: 6-225/272.0
AFNQQYQGLYtgddlrsTGYREKRAFIIAQSPMENTVRDFWKMiLDYKVSAIVMLCGEE----DCCFPYWL--------------SGRKYDEYGLEVTNE
..|  . | |       ...  ..... .. |...|..|||..  ......||.|..||    . |..||                   |  . . .. |
yiNardvggy.......grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

INSNGYTERMFKVSSD-KEAISRNVLQLQVADWPQDGVVREPrtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD-----
.. . |. |.. ..   .   .| |..|.  ||| .|| .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||     
ellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
   .... . .|.  |||| | |||  .|...  .|
nlyleeaveelraqrpgavqteeqylflyeallell
subfamily_PTPN3_pd Subfamily PTPN3 930-1111 2.5e-29 97.1 In-house 84-271 (280) alignment 
Range on Protein: 930-1111
Range on HMM: 84-271/280.0
RAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE----EDCCFPYWLSGR---KYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQ
  .|..| |...|. |||.|. . |.| ||||          |  || .     .| |. .....| ... |  | . ..  ..  .|..||||  .||.
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpd

DGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||  ..  .|.... | .....    |||||||  . |.||.  . . |    |.  | . .. . .|  .   | | .||. . . |
hgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
0041856 (Phosphotyrosine protein) phosphatases II 925-1117 3.3e-29 97.2 In-house 29-173 (182) alignment 
Range on Protein: 925-1117
Range on HMM: 29-173/182.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCgeedcCFPYWLsgrkydeyglevtneinsngytermfkvssdkEAISRNVLQLQVADWPQDG
|..  . ||..| |. .|| ||..|. ......||.|.     ...||                                 |   |...|..   || .|
gslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp................................ellerlgiqylylpwpDhg

VVRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
|   ....|. |..|..      ||||.||||  |.|.|...   . ...    | |..... | ||. .||.|.|..||  ..... ..|. 
vpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 924-1114 5.2e-29 96.0 In-house 85-278 (439) alignment 
Range on Protein: 924-1114
Range on HMM: 85-278/439.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDCcFPYWLSGRK--YDEYGLEVTNEINSNGYTERMFKVSSDK--EAISRNVLQLQVAD
 || ... .| .| | ..|. |||..... |.. ||||.   .  . || |  .  | .  . |  .|.   |. | |||  ..      | |||..   
kGyyddklyiatqgpkkettddfwrlviekktvtivmltnlves.ykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyia

WPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
||.  |  .   ||. .  .   ..|   ||||||||  | |.|   .. | ||| |.|  ||.  . | .|. .   | .| ||  ||. .   
wpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_PTPN14_pd Subfamily PTPN14 928-1116 1.1e-28 95.1 In-house 91-297 (300) alignment 
Range on Protein: 928-1116
Range on HMM: 91-297/300.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE----EDCCFPYWLSG------RKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQV
..| .|.||.|.|.||.|||.|. . .|. ||||  |     . .| |. .        ..... .      .|. .. . .|.        |.|. || 
kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy

ADWPQDGVVREPRTVLQVIDDV---IH-RQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
.|||..|| ..... |. ...|    .  ....       ||.||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.
tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYk

VIDMYLQ
|.  ||.
vlikylk
subfamily_PTPN13_pd Subfamily PTPN13 928-1116 1.8e-28 94.6 In-house 75-270 (273) alignment 
Range on Protein: 928-1116
Range on HMM: 75-270/273.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSG--RKYDEYG---LEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVA
..  .|..| |. .||.|||.|. . |.. |.|.  | .     |  || .   .|   ..   .|. .  . .|.. | ..|.  . . ||.| .|. .
deyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfv

DWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.||  || ...  .||..  | . |.    ||.|||||  . |||.. .. . |.  . .  .|| .. . .|. . | | | .||  .| .|   |.
kwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 930-1111 5.7e-28 92.7 In-house 45-235 (237) alignment 
Range on Protein: 930-1111
Range on HMM: 45-235/237.0
RAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLSGRKYDEYGL---EVTNEINSNGYTERMFKVSSDKEA-ISRNVLQLQVADWP
. .| || |.|..  |||.|. . | | |||| |    .|  |  || |  .   ||     .. . .   || | . .|   .    | . | | . ||
kkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswp

QDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. || ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  ...   .|  . | .||  |...|
drgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 925-1114 7.5e-28 92.3 In-house 67-258 (267) alignment 
Range on Protein: 925-1114
Range on HMM: 67-258/267.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC--GEEDC--CFPYW-LSGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAiSRNVLQLQVAD
||. |.|||. | |..||. ||...| |.||. ||.|   ....    .|      .||..  .| . | . | |    ...   .|. ..||       
gyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknes.ahnvtlyyykk

WPQDGvvrEPRTVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
|  .    . .  |. .  .  . | . |. |.||.||| | ||| .  .   ||. | |||.|.|.  . .|  ..| | |.|.|  |....  |
wnint...nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0036282 (Phosphotyrosine protein) phosphatases II 925-1109 1.3e-26 88.8 In-house 12-164 (174) alignment 
Range on Protein: 925-1109
Range on HMM: 12-164/174.0
GYREKRAFIIAQSPMEntvrdFWKMILDYKVSAIVMLCGEED----CCFPYWLSgrkydeyglevtneinsngytermfkvssDKEAISRNVLQLQVADW
...  . .|. | |..     ||.|. .......|||. |.      |. || .                             ..|  .|...|..   |
lsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredlerlgiqylylpw

PQDGVVREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
| .||   .  .|.... | . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
pDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0043147 (Phosphotyrosine protein) phosphatases II 925-1110 2.3e-26 87.9 In-house 15-156 (172) alignment 
Range on Protein: 925-1110
Range on HMM: 15-156/172.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEedccfpywlsgrkydeyglevtneinsngytermfkvSSDKEAISRNVLQLQVADWPQDG
.|.  . ||. | |. ||. |||.|. ......||.|...                                       |.|  .|...|..   ||  |
lyyipdrfiatqgplrntladfwrmlkelgithivnltel.....................................lydpellerlgiqylylpwpDhg

VVrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
|   .. .|.... . .....  ||||.||||  |.|.|. .   . |        . ..... . ||. .||||.. .||  .|. 
vp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 924-1111 8.4e-26 85.3 In-house 230-434 (440) alignment 
Range on Protein: 924-1111
Range on HMM: 230-434/440.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED-CCFPYWLSGRKYDEYGL---EVTNEINSNGYTERMFKVSSdKEAIsRNVLQLQVAD
 ||  | ||| .| |.. || |||... ||..|.|.||   .|  |  ||    .   .|          | |    | ...   || .  .. |..|  
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelky.keev.heirqfevqt

WP----QDGVVREPR---TVLQVIDDV----IHR---QQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
||     |||  . .   .|||..| .    | |   | . |   |..|||   .  |||.|.|   ||| . .| .||||  . .| |.|  | || .|
wptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdy

TSIYDVI
   | ..
llcykll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 924-1119 6.4e-25 82.5 In-house 74-281 (287) alignment 
Range on Protein: 924-1119
Range on HMM: 74-281/287.0
TGYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE-ED---CCFPYWLSGRKYDE---YGLE-VTNEINSNGYTERMFKVSSDKEAISRNVLQL
..|... ||| ||.|.  ||||||...|. ........  | |.    |. ||   ..      | .  .  .| .  |. | ...   .   .| | ||
asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkql

QVADWPQDGVVRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.. .||....        | ||.| . .  ...  . ||.|||..  . |||.. .. . ... .  | ||| .|   .|  . . | .  |.  .|. .
dllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal

DMYLQMNS
  | . | 
vtyyktnp
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 926-1111 1.4e-24 81.2 In-house 84-232 (392) alignment 
Range on Protein: 926-1111
Range on HMM: 84-232/392.0
YREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--EEDccfpywlsgrkydeyglevtneinsngytermfkvssdKEAISRNVLQLQVADWPQD
.  ..|.| .|.|   .. |||.|... .|..|.|.    | |                                      |    | | | ....||..
fdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......................................kgddartvaqfhftewPdk

GVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.| .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | |||. ||  .
dvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
0049260 (Phosphotyrosine protein) phosphatases II 925-1109 4.6e-24 80.3 In-house 4-144 (152) alignment 
Range on Protein: 925-1109
Range on HMM: 4-144/152.0
GYREKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWlsgrkydeyglevtneinsngytermfkvssdkeaisrnvlQLQVADW
||. ...||..| |..||. |||.|. ......||||. ...    .|  |.                                         | .   |
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlpw

PQDGVVREPRTVLQvIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
| .||   .  .|. . ..|.. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .|.
pDhgvpdlsqlllf.lllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 931-1115 7.6e-24 79.8 In-house 24-173 (176) alignment 
Range on Protein: 931-1115
Range on HMM: 24-173/176.0
AFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDC----CFPYWLSGRKYDEyglevtneinsngytermfkvssdkeaisrnvlQLQVADWPQDGVV
..|. | |...|. ||..|.......|.|.|. | .     |. ||   .|..                                  | .. .||  || 
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.................................qylhlpwpDhgvp

REpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRRSKP-GAVTTLEQYTSIYDVIDMYL
   . .|.... .  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| |||  .|... ..|
dl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_PTPN1_pd Subfamily PTPN1 928-1108 2e-23 77.6 In-house 69-264 (290) alignment 
Range on Protein: 928-1108
Range on HMM: 69-264/290.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC----GEEDCCFPYWLSGRK-----YD--EYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQ
 || .|..| |. |||  ||.|. . |  |.|||      |.  |. || .| .     ..  .. ... .| ... || |....   |   .|..|.  
akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfh

VADWPQDGVVREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSIY
   ||  || . | . |. . .| .    .   ||.|.|||  . ||| .| |   | . ....    ||. .|  ..|. . | . | .|    |
yttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
PTPc_DSPc_SM00012 1012-1111 2.7e-23 77.5 In-house 2-103 (105) alignment 
Range on Protein: 1012-1111
Range on HMM: 2-103/105.0
VLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
| .... .||. || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...| . ||.||. |..|...||.|.|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 929-1108 5.8e-23 76.3 In-house 50-233 (239) alignment 
Range on Protein: 929-1108
Range on HMM: 50-233/239.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWL-SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQD
 .|.| .|  .| .  |||.|. . .   |||| |     .  |. ||  |  || .  . . .      |  | | .|   ..  | | | ... ||. 
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdk

GVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
|| .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
gvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 929-1108 5.9e-23 76.3 In-house 51-234 (239) alignment 
Range on Protein: 929-1108
Range on HMM: 51-234/239.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWL-SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQD
 .|.| .|  .| .  |||.|. . .   |||| |     .  |. ||  |  || .  . . .      |  | | .|   ..  | | | ... ||. 
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdk

GVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
|| .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
gvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_PTPRN_pd Subfamily PTPRN 929-1109 1.3e-21 71.6 In-house 99-286 (297) alignment 
Range on Protein: 929-1109
Range on HMM: 99-286/297.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLS-G-RKYDEYGLEV-TNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWP
. |.| .|.|. .|| |||.|. .  |  ||.|.  |.     |  ||   |   |. | ... .. | .. |  | | .   .   .| | |.    ||
apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswp

QDGVVREPRTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
. ||  .....|.    |  .  .    |.|||||| . |.|||. . . |..  |    .|.    . .|  .|| | | .|.  .. 
eegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 929-1111 5.1e-21 69.6 In-house 93-279 (290) alignment 
Range on Protein: 929-1111
Range on HMM: 93-279/290.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE----EDCCFPYWLS--GR--KYDEYGLEVTNEINSN-GYTERMFKVSSDKEAISRNVLQLQVAD
|  ||..| ....|| |.|.|.|. ||.||||||         | .|.    |.   . |. .  ..| . .     ... |   ..  .  .  |..  
kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkiks

WPQDGVVREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLeQCKAEG-VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
||.  |     ..|...  .  |.     ||||||||  . |.| . .. .|| |.  .|  .|. .. .|.|.|. ..|    ||  . ...
wpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil
0051082 (Phosphotyrosine protein) phosphatases II 932-1110 5e-20 67.1 In-house 15-148 (151) alignment 
Range on Protein: 932-1110
Range on HMM: 15-148/151.0
FIIAQSPMEntvrDFWKMILDYKVSAIVMLCGEE--DCCFPYWLS-GrkydeyglevtneinsngytermfkvssdkeaisRNVLQLQVADWPQDGVVRE
... . |..    ||.... ......||.|..||  . |  |. . |                                  ..||.... |||  |.   
lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg..................................ievlhipildwpdpglpls

PRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
. .||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
fdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
0049772 (Phosphotyrosine protein) phosphatases II 926-1117 8.6e-20 67.1 In-house 83-282 (314) alignment 
Range on Protein: 926-1117
Range on HMM: 83-282/314.0
YrekRAFIIAQSPMENTVRDF----------WKMIL--DYKVSAIVM---------------------LCGEEDCCfpywlsgrkydeY----------G
.   ..||..| |.|.|| ||          |.|.|  |..|  |||                     |..                             
f...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng............neptaadlellk

levtneinsngytermfKVSSDKEAISRNVLQLQVADWPQdGVVREPRTVLQVIdDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGVvD
                 ..  |.|  .|.....   ..|  | .  .. ..... ..|..     ||||.|||.. ..|.|... . . . ..   || .
.................eelydpelferlgikylripvpD.gsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.s

VFQVTKAVRRSKP-----GAVTTLEQYTSIYDVIDMYLQM
. .. . ||.  |     |.. .||||  |.... .||..
leealedvrlkRpinpnpgfieqleqyefilealleylkf
0044763 (Phosphotyrosine protein) phosphatases II 932-1119 4.3e-18 61.0 In-house 30-175 (178) alignment 
Range on Protein: 932-1119
Range on HMM: 30-175/178.0
FIIAQSPMentvRDFWKMILDYKVSAIVMLCGEEDCC----FPYWLSGRKydeyglevtneinsngytermfkvssdkeaisRNVLQLQVADWPQDGVVR
..... |.     |..... ......||.|..|  .     .|||...                                   ..|.. . |..   . .
lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................iqylhipipDhgvpdlle

EPRTVLQVIDDVIhrqqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRRSKPgAVTTLEQYTSIYDVIDMYLQMNS
  . ... |....    .  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .|.  .|..  ..|....
hflefvefieeal....dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 929-1104 9.4e-18 59.0 In-house 89-270 (301) alignment 
Range on Protein: 929-1104
Range on HMM: 89-270/301.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE----EDCC---FPYWLSGR-KYDEYGLEVTN--EINSNGYTERMFKVS-SDKEAISRNVLQLQV
 . ||..|.|..||  ||| |.  |.|  ||||. .    |. |   .| . | . . . . ....|   | ..  ..| ..|  | ..  .| |.  | 
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqy

ADWPQDGVVREPRTVLQVIDdVIHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
..|.. || .    . .... .. . .|    |.|||||. . ||  . .  .   . .|.  ... .  | .|  .  .| | .| 
sewtdrgvPkshaelfdlme.lvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 927-1117 4.6e-17 57.0 In-house 79-273 (288) alignment 
Range on Protein: 927-1117
Range on HMM: 79-273/288.0
REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC-----GEE--DCCFPYWLsGRKyDEYGLEVTNEINSNGYTERMFKVSS---DKEAISRN-VLQL
. || .| ||.|.. |.  .|||.|.  |  |||||     | |  .  ||  | |.|   .|   |   ...   ... |||     ||   .  | .|
kykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl.Gek.arigrlctvvkkkradidklvkvsllriskegeekvivkil

QVADWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 . .|..|||  .  . |.... . .  ||    |.|||.|  | |.|    . | ||. . .  . . .. .  | ..  |..|  ||  .. ..  .|
hlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

QM
 .
ll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 929-1115 2e-16 54.9 In-house 81-277 (307) alignment 
Range on Protein: 929-1115
Range on HMM: 81-277/307.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSGRKYDEYGLEVTN--EINSNG-----YTERMFKVSS---DKEAISRNVLQ
 . || || |.|||. .|| |... || ...|||   .     |  ||   .       | .|   ..  |       | . .|..   |    || . .
pkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqh

LQVADWPQDGVVREPRTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIGLEQ-CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
||  .||. || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  .. |.  
lqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

YL
|.
yf
subfamily_egg_pd Subfamily egg 930-1115 2.6e-16 54.2 In-house 83-270 (307) alignment 
Range on Protein: 930-1115
Range on HMM: 83-270/307.0
RAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE--DCCFPYWLSGRKYDE----YGLEVTNeINSNGYTERMFKVSSDKEaISRNVLQLQVADWPQD
  ||.||.|. ||| |||.|.   .|  ||||      . |  ||    .        .|...| .. .  .. .|.|.  |  .  .  .. .  |  |
nefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrien.lkvdskadplfrvtklkl.vGgddeerflehwqgd

gvVREPRTVLQVIDdvIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV--DVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  |..   |   .   . |. .    ||||.. . ||....  .. | | .     ..   | .  . .|. .. .| .  .|  .| .. ...
..vnnssdvysplr..vlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 930-1118 5.9e-16 53.4 In-house 60-262 (290) alignment 
Range on Protein: 930-1118
Range on HMM: 60-262/290.0
RAFIIAQSPMEN-------TVRDFWKMILDYKVSAIVMLCGEED--------CCFPYWLS----GRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAiSR
 ..|. ||| |.       |. .|| |. . ||  .||||  |.         |  |         |..   .. .. .. ..  .|   |  |.|    
lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddee.ef

NVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
 |   .. .| .  | ....|.|..|. |  ..      ||.||| | .||| .  .. .|       .| | . .| ||.|. .  |.|. .... .  
tvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda

VIDMYLQMN
.| ....  
givllaiev
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 928-1110 1.3e-15 52.1 In-house 3-199 (199) alignment 
Range on Protein: 928-1110
Range on HMM: 3-199/199.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE---DCCFP-YWLSG----RKYDEYGLEVTNEINSNGYTERMFKVSSDKEA--ISRNVLQLQV
 .| .| .| |. .|. |||.|. .     |||.  ..   .. .| || .      ||    . .        ||   . ....  |   .|.. . | 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

ADWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
. | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 929-1110 1.6e-15 51.8 In-house 3-198 (198) alignment 
Range on Protein: 929-1110
Range on HMM: 3-198/198.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE---DCCFP-YWLSG----RKYDEYGLEVTNEINSNGYTERMFKVSSDKEA--ISRNVLQLQVA
.| .| .| |. .|. |||.|. .     |||.  ..   .. .| || .      ||    . .        ||   . ....  |   .|.. . | .
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 929-1111 2.2e-15 51.1 In-house 80-265 (281) alignment 
Range on Protein: 929-1111
Range on HMM: 80-265/281.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWL----SGRKYDEYGLEVTNEI-NSNGYTERmFKVSSDKEaiSRNVLQLQVAD
|| .|..| | ..|  |||.|| . . .||||||     . . |  |.        ..|.. ..  .   |    | | ...| . |  .| . .    .
krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr.lnlsyege..trlithwlwke

WPQDGVVREPRTVLQVIddvihRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRS-KPGAVTTLEQYTSIYDVI
||.  |      .|...     |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| . .  .| ||.||  |. |.
wpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 931-1111 3.5e-15 50.7 In-house 77-291 (297) alignment 
Range on Protein: 931-1111
Range on HMM: 77-291/297.0
AFIIAQSPMENTVRDFWKMILDYKVSAIVMLC----GEEDCCFPYWLSGRKYDEYGLEVTNEINSNG---YTE-RMFKVSSDKEAISRNVLQLQVADWPQ
 .|.|| |...|| |||... .  | .|||..    .  | |.||| |  .      .|  |  |.    .    . ..     . || |   |   ||.
kyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpd

DGVVR----EPR-------------TVLQVID---DVI------HRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPG
 ||        |              .| ...    ..       | ..    ...||||  | ||||     . |.. . . . ||  . . .|  .. 
hGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrar

AVTTLEQYTSIYDVI
 | ||||.. .||..
lvqtleqfellydav
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 930-1115 5.3e-15 49.8 In-house 96-289 (305) alignment 
Range on Protein: 930-1115
Range on HMM: 96-289/305.0
RAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE----DCCFPYWL--SGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAIS------RNVLQLQV
. || || |...|. .|| |... ||  |||||         |  ||    | | .  .  | ...  .   ||  ..      ..        | .|| 
krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqw

ADWPQDGVVREPRTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIGLEQCKA-EGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
..||. ||     | |...  .  |  |.   |.|||||  . |.|   ..   ||.      .  . .. ||.|  .  .. .  ||  |. |.  |.
tewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 928-1120 8.8e-15 49.2 In-house 86-292 (305) alignment 
Range on Protein: 928-1120
Range on HMM: 86-292/305.0
EKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEE----DCCFPYWLSGRK----YDEYGLEVTNEINSNGYTER----MFKVSSD------KEAIS
. . || .|.|.|.|  ||| | |. || || |||         |. |. |  |    ..| |  ..  ..| .  .       ||.          . .
npkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgeka

RNVLQLQVADWPQDGVVREPRTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV-DVFQVTKAVRRSKPGAVTTLEQYTSIY
| | .    |||. ||     ..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  .. . .|  .  .. | .||  ..
rkvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh

DVIDMYLQMNSM
.||  |.. . .
qvilnyfrkkkl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 929-1110 1.3e-14 48.5 In-house 93-285 (310) alignment 
Range on Protein: 929-1110
Range on HMM: 93-285/310.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--EE--DCCFPYWLSGRKYDEYG-LEVTNEINSNGYTE--------RMFKVSSDKEAISRNVLQL
. .|| .| |.. |. |||.||.. .  .|..||   ||    |  || |    . || . |||  .|    |           .|  |..    . |..
rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrv

QVADWPQDGVVREPRTVLQVIDDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
..  ||.      |    . . . .  |  .  ||.|||||  . | .| ... . ... .    ||. .|   ...|.   . |  ||. |  |
slikwpnwpdrgvpdekchtvpqrllaq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
0048076 (Phosphotyrosine protein) phosphatases II 982-1114 1.7e-14 49.2 In-house 36-142 (145) alignment 
Range on Protein: 982-1114
Range on HMM: 36-142/145.0
GlevtneinsngytermfkvSSDKEAISRNVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiGLEQCKAEGvV
                    .|..|  .|...|..  .||  ||   ....|.... . . ...  ||||.||||  |.|.|...    ..  .. .| |
l...................tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.v

DVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
..... . ||.  ||||.. .|.  .|... ..
sleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 936-1107 3e-13 43.9 In-house 97-280 (302) alignment 
Range on Protein: 936-1107
Range on HMM: 97-280/302.0
QSPMENTVRDFWKMILDYKVSAIVMLCG----EEDCCFPYWLS----GRKYDEYGLEVTN-EINSNGYTER----MFKV----SSDKEAISRNVLQLQVA
  |  .|.  .| .| .|.|. .| ||.    ||  | .|.        |. .| ..  . . . . .|..    ...|    .  |..  . |  |. .
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

DWPQDGVVREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
 ||. |  .|. | |...      ...     |.||||  | |.|   ..  |.. |. . | |. .. . ||. . ||| . .| . .
awpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
0048179 (Phosphotyrosine protein) phosphatases II 950-1109 1.3e-12 43.2 In-house 25-139 (144) alignment 
Range on Protein: 950-1109
Range on HMM: 25-139/144.0
ILDYKVSAIVMLCGEEDCCFPYWLsgrkydeyglevtneinsngytermfkvssdkeaisrnVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQkiGGG
. ........ |. | .  |.                                         ..|..  .||  ||   .  .|.... . . ..   ||
lkklgittvinlteeyepeflere......................................giqylhlpwpDhgvpdllellleflefieeale..egg

PVVVHCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
||.||||  |.|.|...        .| .| ...... . ||.  ||||.. .|.  ...
pvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
fn3 Fibronectin type III domain 119-193 1.4e-12 40.8 Pfam-A 2-79 (85) alignment 
Range on Protein: 119-193
Range on HMM: 2-79/85.0
APSSLTEVSQTATTITVSWTALD--SSDADGYVVNVTSDTDT--VQTVQVEGSSNnTITLNGLRELTTYSITVRAYQQL
||. |.  ..|.|..|.||.. .  ... .|| | . .....   ....|..... . ||.||.. |.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 931-1121 1.6e-12 41.7 In-house 83-282 (312) alignment 
Range on Protein: 931-1121
Range on HMM: 83-282/312.0
AFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE----EDCCFPY---------WLSGRKYDEYGLEVTNEINS-NGYTERMFKVSSDKEAISRNVLQLQ
 |...|.|.|||.  ||.. |    ..|..|||      . |  |             | | ||  |.    .| .  | |..||         .. . |
rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyq

VADWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYC---SVSIGLEQCKAEGVVDVFQVtkaVRRSKPGAVTTLEQYTSIYDVIDM
 | ||. |.     | |...  | ....|    ||. |||  | |.|  .   |.   | . . . | |.| .   .|. .  .| .. ||     ..  
waswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvle

YLQMNSMY
.|  ...|
flyskgly
subfamily_ptpA1_pd Subfamily ptpA1 930-1072 2.3e-12 41.4 In-house 89-253 (418) alignment 
Range on Protein: 930-1072
Range on HMM: 89-253/418.0
RAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED-C---CFPYW---LSGRKYDEYGleVTNEINSnGYTERMFKVSSD--KEAIS-----------
. || .| |. ||. |||.|. . ..  ||||  | . |   |  ||   . | ..  ||    ||.    |.  . .|  |  .| |.           
kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiyg..ngnevfg.tysvelveviqdpereiitrnirltfeget

RNVLQLQVADWPQDGVVREPRTVLQVIDDVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIGL
|.. | |   ||.  .    . . |..  .  ||..|        |..||||  | |.| .|.  | .
rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 930-1117 3.1e-12 40.5 In-house 90-287 (302) alignment 
Range on Protein: 930-1117
Range on HMM: 90-287/302.0
RAFIIAQSPMENTV---RDFWKMILDYKVSAIVMLCGEEDC------CFPywLSGRKYDEYGLEVTNEI--NSNGYTERMFKVSSDKEAISRNVLQ--LQ
|  |.|| |  ...    .||.|. . |.  .|.| |||..       ||  .   .| |||    |    ..   .. .. .    | .|  ||     
rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfp..kksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyv

VADWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.  |.|. |  .  .. . . .| . ..  .  ..|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|.||.|.| .. .|..
ltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

M
 
k
subfamily_CG42327_pd Subfamily CG42327 1047-1115 4e-12 40.4 In-house 246-315 (319) alignment 
Range on Protein: 1047-1115
Range on HMM: 246-315/319.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  ||.|||||| | |.|.  .  | ... .     ||. |.   ||| .  || | |||  || |. .| 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
fn3 Fibronectin type III domain 558-637 9.8e-12 38.0 Pfam-A 3-85 (85) alignment 
Range on Protein: 558-637
Range on HMM: 3-85/85.0
PSSIQVLPVNSTANNLTWNEVNcsERNGLITGYTVIISNS-----SITYNLTSTERYIILNDLVFGSEYNISVAAVNSVGRGPFS
|. ..| .|.||  .|.|.. .  ...| ||||.|  ...     . ......|..  .|..|  |.||...|.||| .| ||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 927-1115 1.9e-11 38.5 In-house 72-270 (285) alignment 
Range on Protein: 927-1115
Range on HMM: 72-270/285.0
REKRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLC-----GEEDCCFPYW--LS-GRKYDEYGLEVTN--EINSNGYTERMFKVSSDKEAISRNV--LQ
... ..| .| |. .|. |||.|| . |.. ..|||     | | |.. |   |    |. .| . .|.  |    |     . |   ..| |  .   .
kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnh

LQVADWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
.||  ||..    . | ....   | . . |    |..||||  | |.  .  .     .   .  ...... . .|  .  || .  |.  .| |.  |
vqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey

L
.
f
fn3 Fibronectin type III domain 451-539 9.2e-10 31.7 Pfam-A 2-81 (85) alignment 
Range on Protein: 451-539
Range on HMM: 2-81/85.0
APSPPTEVNKTATTITVNWTALD--SSDADGYVVNVTSDTDTVqtvqlssVNETVSVDPHqsttTYSYTLIGLYSGMNYTIIVRAGNVLGG
||. ..  . |.|..|..|.. .  ... .|| | . .....        .  ...|...    |.|.|| ||  |..|.. |.| |  |.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.......ewkeftvprt....ttsvtltgLkpgteYefrVqavngage
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 923-1004 3.1e-08 27.7 In-house 101-181 (350) alignment 
Range on Protein: 923-1004
Range on HMM: 101-181/350.0
STGYrekrAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEED----CCFPYWLSGrKYDEYGLEVTNEINSNGYTERMFKVSSD
 ...     .| .|.|. .|| ||.|.||  ||  |..|  . .     |  ||  | .||.. . ...  .. . .. . . |.|
npdf....kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg.sydditvklaskwenimgindsslysad
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 931-1026 1.1e-07 25.7 In-house 138-236 (244) alignment 
Range on Protein: 931-1026
Range on HMM: 138-236/244.0
AFIIAQSPMENTVRDFWKMILDYKVSAIVMLCG--EEDccfPYWLSGRKYDEYGLEVTNEI----NSNGYTERMFKVSSDKEAISRNVLQLQVADWPQDG
 .|..| |. .|  |||||.|. .|  .|.|    |||    ||      . |  ..|  .    .        ... || .   . .  .|...|| ||
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed...eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg

VV
  
tt
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 929-1026 1.5e-07 25.8 In-house 27-127 (130) alignment 
Range on Protein: 929-1026
Range on HMM: 27-127/130.0
KRAFIIAQSPMENTVRDFWKMILDYKVSAIVMLCGEEDCcFPYWLSGRKYDEYGLEVTNE----INSNGYTERMFKVSSDKEAISRNVLQLQVADWPQDG
 . .. .| |. .|  |||||.|.  |  .|.|   |.    ||     .. |  ...       ...      ....||     . .  .|...|| ||
taeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.deywpdsePlewyeediivtltdrdefknikasnleiesdlneshqaltmfqisnwpsdg

VV
  
tt
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1052-1111 2.3e-07 25.1 In-house 2-61 (69) alignment 
Range on Protein: 1052-1111
Range on HMM: 2-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1052-1112 8.2e-07 23.3 In-house 1-61 (69) alignment 
Range on Protein: 1052-1112
Range on HMM: 1-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| . 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1011-1073 2.6e-06 21.4 In-house 216-287 (350) alignment 
Range on Protein: 1011-1073
Range on HMM: 216-287/350.0
NVLQLQVADWPQDGVVREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLE
 |.||||  |.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....   |.
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDslls
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 929-1120 2.7e-06 21.2 In-house 83-284 (303) alignment 
Range on Protein: 929-1120
Range on HMM: 83-284/303.0
KRAfIIAQSPMENTVRDFWKMILDYKVSAIVMLCGE-------EDCCFPYWLSGRKYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQ-VADW
|.| |..| |.  |  |||.||.. ||  ...|  .        |  ||      |..|  . | .  . .      .|| |  .   .  |...   .|
kka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykaw

PQDGVVRE--PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIG-LEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
|.. .  .  |. | |. .     ..   . | |      . |.| ..      |   . .  .|. .. . ||  .  ||  | |.. .| ..  ..  
phnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld

NSM
| .
ngi
fn3 Fibronectin type III domain 654-747 3.3e-06 20.3 Pfam-A 8-85 (85) alignment 
Range on Protein: 654-747
Range on HMM: 8-85/85.0
VSSImDTTLAVISWSVPSyiPSDYPIITYEIGYHILESGNcsvvddddidnqrL----QfinsTNGNTFTSRITDLNAMSCYIFGVRAYTDNGYGEWT
||..  .| ...||| |.  . . ||  ||. |   ..|.                  .    . ..| .  .|.|.. . | | |.|....|.|...
vsev.tstsltlsWsppk..dgggpitgYeveyrekggge.............ewkeft....vprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 942-1123 4e-06 21.1 In-house 40-230 (255) alignment 
Range on Protein: 942-1123
Range on HMM: 40-230/255.0
TVRDFWKMILDYKVSAIVMLCGEE-----DC--CFPYWLSGR-KYDEYGLEVTNEINSNGYTERMFKVSSDKEAISRNVLQLQVADWPQDGVVREPRTVL
||  |...|   | . .||||  .     .|   ||  . .. |. .  . .|. ..      .       .    ..|   .   |..    ...| .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

QVIDDVihRQQKigggPVVVHCSDTVSRSGVYCSVSI-------GLEQCKAeGVVDVFQVTKAVRRSKPGAVTTLEQ-YTSIYDVIDMYLQMNSMYGN
...  |  |. |    .||||||  . ||  .  . .        |.. .. . .|  .. . .| ....|. |  |   ||. |.|..   . .  .
nilkvv..rdsk....svvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleak