Gene PTPRD-58 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP115_AA protein Get Run
AqueP115_AA_805-1069 phosphatase_domain Get Run
AqueP115_AA_1081-1277 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 792-1177 6.2e-133 439.4 In-house 4-396 (564) alignment 
Range on Protein: 792-1177
Range on HMM: 4-396/564.0
PVSVDELGTHVATCHSN---GFDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLdmCEREYINASYIDGYSSSNKFIASQGPMK
|..|.|| .|||  ..|    |.|.|........ ...  . ..|   ||..||. || .|..|.. ..    . .|||||.|||| .....||.|||..
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPla

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNK-SEEFGPFTVMLISQQVYPDFVIRQLNVkIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLM
.|. ||||..|...  .|||.|.|.| .| ||..|||.| .|..| .|| | ... . |..||....  .  |..|.. .|.| |||||||||..||.|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslL

SLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQEL
.| ..| |...| .|||.||||||||||||||.||. ||..| |..||| ..|..||.||  |||| .||.|.|.|.|||. ||.|..........||.|
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

KEIDSSTGCSGLQSQFDLLSQVT-PDPDDVFTNTAKAYPAKNRSSKFLPVELFLVPL-----QEANGYINASFISGFHEKRAFIIAQSPMENTARD
.|... |. .||.  |. |.  .  ....  . | .    ||| |. |..|   | |     .|   |||||.. ...|||||| .|.|..||  |
aeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntved
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 796-1073 2e-129 425.6 In-house 3-298 (301) alignment 
Range on Protein: 796-1073
Range on HMM: 3-298/301.0
DELGTHVATCHSNGFDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFW
..||||||..|||.|.|||..|.. ..|.||.|...||. .||||||||||||||||||.||||.|.|||||||||||||...||||.||||||||||||
edlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfW

RLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN---KSEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSN--------------DSHTLTQYHLTSWPDHG
|||||||||||||||||||||||||||||||   .|||||||||.|...||||||||||||||||||||              .|....|...|.||..|
rliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdG

V-PDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGET
| ....| |...............||..||||..|.|.|......|.|||.|.|||||. ......|......|.||.||....|.. . . . .|
vvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 792-1088 7.8e-124 407.7 In-house 3-303 (305) alignment 
Range on Protein: 792-1088
Range on HMM: 3-303/305.0
PVSVDELGTHV---ATCHSNGFDEQYENLSNPhSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDmcEREYINASYIDGYSSSNKFIASQGPMK
....|.| ...    . ...|...||..| .  .. . .|....|   ||.|.||..||.||||.....||  ...||||||.|||....|.|..|||.|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEE---FGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATP
.|..||||||..||...|||.|.|.|| |.||.||||..  |   ||.|.|.| |.. ..|...|.|.. |.|....|.|..||.||.|||||||..|| 
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

LMSLHKQVMATWSPSKG-PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKL
|.|| |.|. ... .|| |.||||||||||||.|||.|||||..|.|.|||.......||..|||||||||||||||||. | |.||.|.|  . .. ..
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

QELK
. ||
nklk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 793-1104 3.2e-95 313.8 In-house 2-316 (318) alignment 
Range on Protein: 793-1104
Range on HMM: 2-316/318.0
VSVDELGTHVATCHSNG---FDEQYENL-SNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPnlDMCEREYINASYIDGYSSSNKFIASQGPMK
.||..| .||.  ...|   ..|.||.|  ....   .    . |   ||. ||. ||. |. |..    .  . .||||.||||| .....||.|.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmle..geegsDyinanyidGyrrkkayiaaqaPlp

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNK-SEEFGPFTVMLISQQVYPDFVIRQLNVKIqDGSNDSHTLTQYHLTSWPDHGVPDYATPLM
.|. ||||..|. .   |||.|...| .| |...|||.| |...|  .| | ..  . |.|.|...|.  .....| .  ||| |||||.|||. .. |.
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgasll

SLHKQVMATW-SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQE
.| .|| ..  ....|||.|||||||||||.|||.|| ||..| |..||. ..|..||.||  |||| |||.|..|..|||...|.|.. ... .....|
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire

LKEIDSSTGCSGLQSQFD
|.| |. .| . .. .|.
lreqdpesgttemdaefq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 792-1103 5.1e-94 309.9 In-house 4-318 (319) alignment 
Range on Protein: 792-1103
Range on HMM: 4-318/319.0
PVSVDELGTHVATCHSNG---FDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNldMCEREYINASYIDGYSSSNKFIASQGPMK
.. |.|| ... . .|.|   .......|... ..  .  ...||.  ||..||  ||  |..|.. ..  . . .|||||.||||   .|||| |.|..
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqaPle

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKS-EEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLM
.|. ||||..|.|.   .||.|.|.|  | |...|||..  ||.| ..| | ...   |..||.|..... .  .. ...... |.||||.||..|| |.
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

SLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQE
 | |..  ...  ..||| ||||||||||||||..|..||. |.|||.|.  .|.||| ||  |||. .|| |...|.|||. .|.|.|  .. ...|..
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

LKEIDSSTGCSGLQSQF
|.| .. || .||. .|
laekvadtgetgleref
subfamily_PTPRK_pd Subfamily PTPRK 802-1103 1.8e-93 307.8 In-house 16-312 (314) alignment 
Range on Protein: 802-1103
Range on HMM: 16-312/314.0
VATCHSNGFDEQYENLSNPhskrCTIGHRDENSGFNRFKNITVYDDNRIILKPNpnLDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQE
. .... || |.||.| .         ..|||   ||...|  ||  |..|..    .  . .||||..||.|  ...||. |||...|. |||||...|
lkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvfliti..dgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvyde

KPVSIVMVTNLKEGTKSKCEQYWPNKSEEFGPFTVMLISQQVYPDFVIRQLNVKI-QDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPS
.  ||||.|.|.| .. || .|||...| .|.. |.|.. ..  ..|.| ..|.  . | .. ... |.. ..||||.|| .|| |..| ..| ..  ..
ncasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeee

KGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQELKEIDSSTGCSGLQ
.|.|.|||||| ||||||||||| |. ..||||||.  .|  ||.... ||.| .||.|..|..||| .|||| ||. ....   | ...|. |  | |.
aGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlk

SQF
 .|
eef
0040438 (Phosphotyrosine protein) phosphatases II 808-1105 2.7e-93 308.0 In-house 18-313 (317) alignment 
Range on Protein: 808-1105
Range on HMM: 18-313/317.0
NGFDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNldMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
... |..|.| . .   ...... || ..||...|  ||..|..|.| ..    .  ||||||.||.. ..|||| |||...|. ||||..|...  .||
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MVTNLKEGTKSKCEQYWP-NKSEEFGPFTVMLISQQVYPDFVIRQLNVKIQdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILV
|.|.|.|  . ||.|||| ... ..|.||| |.| ........|.| |.   |...|.|.|..| |.|||||||.. ..| .. ..| .  ....||.||
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlV

HCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQELKEIDSSTGCSGLQSQFDL
||||||||||||||....||| ..|| ||.  .|..||.||...|||..||.||.||.|| . ...|..|  .. .||..|....  .. .. .....|
HCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkekelkl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 793-1072 4e-93 306.4 In-house 2-287 (290) alignment 
Range on Protein: 793-1072
Range on HMM: 2-287/290.0
VSVDELGTHVATCHS---NGFDEQYENLSNPHS-KRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDMCEREYINASYIDGYSSSNKFIASQGPMK
. ||..| .||. |.   .|| .|.. | . .| .  |.|   .|.  |||.|| |||||||.|.| ..   |. |||||.||.||. ....|| |||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNK-SEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHG-VPDYATPL
.||||||.||||||   |||.|| .|  | || ||||.. ....|.|.. |...... ....|.|.|| .. .......|||..|.|...| |....| |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

MSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGE
.......   . . ...|.||||..|||...|.|........| |||.|.  .....|.|....||| .|| .... ||... . |
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 793-1074 3.1e-92 303.6 In-house 2-284 (287) alignment 
Range on Protein: 793-1074
Range on HMM: 2-284/287.0
VSVDELGTHVATCHS---NGFDEQYENLSN--PHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKpnpnldMCEREYINASYIDGYSSSNKFIASQGPM
..|...|  ||. |    .|| .|.  | .   . .  |..   .|   ||...| |.|..|..||       .. .||||..||||.....||....||
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPm

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKS-EEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHG-VPDYATP
 .|...||.||.....  |||....|| ....| ||||...   .|.....|....|. ....|.|.|| .. ..| ....||..|.|...| |....| 
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

LMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETK
|. ..... .   .....|.||||..|||...|.|........|.|||.|.  .... |.|....||| .|| |. |.||| . ..||.
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
0051299 (Phosphotyrosine protein) phosphatases II 810-1068 2.1e-91 301.6 In-house 25-286 (288) alignment 
Range on Protein: 810-1068
Range on HMM: 25-286/288.0
FDEQYENLSN-PHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNldMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
. |..| | .  ..  ...... ||   ||...|  ||..|..|.. ..  . .  |||||||||| ...|||| |||...|. ||||..|...   |||
lleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvm

VTNLKEGTKSKCEQYWP-NKSEEFGPFTVMLISQQVYPDFVIRQLNVKIQD---GSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPI
.|.| |  . ||.|||| ..|...|..|| |.| .|..|...|.| |.  |   |.. |.| |..| |.||||||||....|... ..|.   ....||.
ltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpv

LVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAI
.|||||||||||||||.|..||| ..||.||. ..|.|||.||. ||||..||.|...|.||..
vVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 814-1075 9.9e-91 299.6 In-house 49-306 (308) alignment 
Range on Protein: 814-1075
Range on HMM: 49-306/308.0
YENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILkpnpnlDmCEREYINASYIDGY--SSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTN
.| ||.. .  .... . ||  .||.|.|  || .|..|      |  .  ||||||.|||   ...|||| |||...|. ||||..|...   |||.|.
eellsvkplleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtk

LKEGTKSKCEQYWPN----KSEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWspSKGPILVH
| |  . ||.||||.    .|.|.|.||| |.|..|..|...|.| ..  ... .|.|.|..| |.|||||||.....|... ..|  .   ..|||.||
lvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVH

CSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKI
|||||||||||||.|..||| ..|| ||. ..|..||.||. ||||..||.||..|.|| . . .||.
CsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
0046845 (Phosphotyrosine protein) phosphatases II 810-1075 3.8e-90 297.4 In-house 2-281 (284) alignment 
Range on Protein: 810-1075
Range on HMM: 2-281/284.0
FDEQYENLSNPHSK---RCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNlDMCEREYINASYIDGY-----SSSNKFIASQGPMKKTLVDFWRLIWQE
..|..| | .   |    ...... ||   ||.|.| .||..|..||. .. |. . .||||||.|||      ...|||| |||...|. ||||..|..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPVSIVMVTNLKEGTKSKCEQYWPNK--SEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS-
.   |||.|.| |  . ||.||||..  . ..|.||| |.| .|..|...| | ..  . .. |.|.|..| |||||||||.....|... ..|    . 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-PSKGPILVHCSAGVGRTGTFIAIDIALEQAKREG---VVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKI
 |..|||.|||||||||||||||.|..||| ..||   .||. ..|.|||.||. |||||.||.|...|.||.. .. |..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0036941 (Phosphotyrosine protein) phosphatases II 814-1081 3.8e-90 297.5 In-house 20-290 (297) alignment 
Range on Protein: 814-1081
Range on HMM: 20-290/297.0
YENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILkpnpnlDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLK
.| |.. ..  ...... ||   ||.|.|  ||..|..|      |  .  ||||||.|||. ..|||| |||...|. ||||..|...  .|||.|.| 
eellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelv

EGTKSKCEQYWP---NKSEEFGPFTVMLISQQV--YPDFVIRQLNVKIQdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILV
|  . ||.||||   ..| ..|.||| |.| .|  ..|...|.| |.   |...|.|.|..| |.|||||||.....|... ..|      .||.||.||
elgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlV

HCSAGVGRTGTFIAIDIALEQAK---REGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQ
||||||||.|||||.|..|.| .   .|| |||  .|. ||.||. .||||.||.||..|.|| . ...||.| .|. 
HCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklv
subfamily_PTPRB_pd Subfamily PTPRB 792-1069 3.6e-89 293.7 In-house 6-286 (293) alignment 
Range on Protein: 792-1069
Range on HMM: 6-286/293.0
PVSVDELGTHVATCHS---NGFDEQYENLSNP-HSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPnlDMCEREYINASYIDGYSSSNKFIASQGPM
|...... .||.. ..    .| |.||.|..  ... ... .. .|.  ||..||  || .|. |..    |  . .||||.||.||.| ..|||.|||.
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyipgynsprefiatqGPl

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNK--SEEFGPFTVMLISQQVYPDFVIRQLNVKIqdgSNDSHTLTQYHLTSWPDHGVPDYATP
 .|. ||||..|..|   |||.|.| |. | |||.|||..  .  .|  .| |...... |.|||.|...    ........||| |||||||||. ...
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektkt

LMSLHKQVMATW--SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAII
|... ..|  .   . ||.||.|||||||||||||||.|  |.. ..| .|||.||| .||..|. .||| .||.|.|..||. . 
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 804-1177 6.9e-89 293.3 In-house 14-386 (515) alignment 
Range on Protein: 804-1177
Range on HMM: 14-386/515.0
TCHSNGFDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPnlDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKP
  |   | |.. .|  |     |.   . |   ||.|||  || .|..|.     |  . .|.||||| .. . . .|||||| | .. |||||..||..
nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenv

VSIVMVTNLKEGTKSKCEQYWPN---KSEEFGPFTVMLISQQVYPDFVIRQLNVKIqdGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPS
  |.|||.|||| |.|| .|||.   .| .|| . | |.| .   . ..|.|.|    |. ||.|.||.|.| |||.|||  .. |. | |.| |  .  
ttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlk..gd.dsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqy

KGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQELKEIDSSTGCSGLQ
. |...|||||||||| .|.||  . .||   .||.  .|. .||.|...||| .|| |...|||| .   .| ||  ..  .||.|.      | | . 
thpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmt

SQFDLLSQVTPDPDDVFTNTAKA--YPAKNRSSKFLPVELFLVPLQEA-NGYINASFISGFHekRAFIIAQSPMENTARD
 .|. |  ..|||    | ....     ||| .. ||..   | |.   . ||||| . | |   .|. .| |.  |  |
kefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildspdhdyinasqmkgih..ctfmttqmplpttvsd
0039614 (Phosphotyrosine protein) phosphatases II 806-1073 2.4e-88 291.7 In-house 30-294 (297) alignment 
Range on Protein: 806-1073
Range on HMM: 30-294/297.0
HSNGFDEQYENLSNPHSKrCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDMcEREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPV
 ........|.| .     ..|... ||  .||.|.|  ||..|..|||... |. .  ||||||.|||.  ..||||.|||...|. ||||..|...  
sktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvt

SIVMVTNLKEGTKsKCEQYWPNKSEEFGPFTVMLISQQVYPDFVIRQLNVKIqdgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS--PSKG
.|||.|.|.|  . ||.||||......|.||| |.. ........|.|.|.    .. |.|.|... |.|||||||.... |... ..|.   .  |..|
vivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkgg

PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGET
|.||||||||||||||||....||| ..|| ||.  .|..||.||...|||..||.||.||.|| . .. |
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 804-1075 4.7e-87 287.0 In-house 23-297 (298) alignment 
Range on Protein: 804-1075
Range on HMM: 23-297/298.0
TCHSNGFDEQYENLSNPHS----KRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPnlDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIW
. .  |.......|..  |    .  ......||   ||. .|  .|  |..|. .   .  | .|||||....|. .| |||.|.|...|..||||...
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

QEKPVSIVMVTNLKEGTKSKCEQYWPN-KSEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtWS
.|.  .|||.|||.|  | |...|||. ..|..| .|| | |.... |...|.|.|. .. . ..... | | |||||.||| .|| .. | ..| | . 
eedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sq

PSKG--PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKI
   |  |..|.|||||||.|||||||  ||..|.| |||.  .|..||..|...||| .||||...|||||. .....|
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0043336 (Phosphotyrosine protein) phosphatases II 807-1066 1.4e-86 285.7 In-house 19-275 (278) alignment 
Range on Protein: 807-1066
Range on HMM: 19-275/278.0
SNGFDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNldMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSI
  .. ...|.| . .   ..|... ||  .||.|.|  || .|..|.. ..       ||||||.|||. ..||||.|||...|. ||||..|...  .|
ktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

VMVTNLKEGTKSKCEQYWPNKSEEFGPFTVMLISQQVYPDFVIRQLNVKIqDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILV
||.|.|.|  . || ||||..|...|.||| |.......|...|.|.|.   |.. |.| |.|| ..|||||||.  ..|... |.|.   ..|.||.||
vmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlV

HCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
||||||||||||||....|||...|| ||.  .|..||.||...|||..||.||..|.||
HCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0047943 (Phosphotyrosine protein) phosphatases II 817-1068 1.4e-86 285.6 In-house 22-272 (273) alignment 
Range on Protein: 817-1068
Range on HMM: 22-272/273.0
LSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILkpnpnlDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGT
||....  .... . ||  .||.|.|  ||..|..|      .. .  ||||||.||| ...|||| |||...|. ||||..|...   |||.|.| |  
lslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelg

KSKCEQYWPNK----SEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNdSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSP--SKGPILVHCSA
. ||.||||..    |...|.||| |.|.....|...|.| ..  . .. |.| |..| |.|||||||.. ..|... ..|. . .   |.||..|||||
rekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsa

GVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAI
||||||||||.|..|.| ..|| ||.  .|..||.||. ||||..||.||..|.|| .
GvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 792-1104 3.2e-86 284.1 In-house 5-315 (315) alignment 
Range on Protein: 792-1104
Range on HMM: 5-315/315.0
PVSVDELGTHVAT---CHSNGFDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNlDmCEREYINASYIDGYSSSNKFIASQGPMK
|. .|.| |.||       ||| ..||..   . .   . .. ||   ||. ||  ||  |. |    | |  . .|.||..||||.  ...||.|||  
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllen.d.phsdyvnanfidGynkkrryiaaqgpnv

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEEFGPFTVMLISQQVYPDFVIRQLNVKIQDgsnDSHTLTQYHLTSWPDHGVPDYATPLMS
 .. |||||...|.   |||.||| || |.|.|.|||.|   .|..|| ..|..|. .. .| | |  .|   . ... |.|.||||| ||| |..||| 
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgd...nirevvqlhytswpdmgvpkytiplmn

LHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQELK
|...|.     | |.|.||||||||||||||..|  |.||. | ..|.  .....||.|.||||...|| |..||.||...||.| |  | |  . . | 
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsll

EIDSSTGCSGLQSQFD
     || . || ||.
apspdtgstllqeqfe
subfamily_PTPRG_pd Subfamily PTPRG 793-1080 3.3e-86 284.7 In-house 1-299 (563) alignment 
Range on Protein: 793-1080
Range on HMM: 1-299/563.0
VSVDELGTHVATCHSNG---FDEQYENLSNPHSKR---CTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDMCErEYINASYIDGYSSSNKFIASQGP
| |.|.  ||| .|..|   |.|..|.| . . ..   ..  .. ||   ||  ||. ||  |. |.| |. .    .||||.|||||  |..|||.|||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

MKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN-KSEEFGPFTVMLISQQVYP-----DFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVP
.|.|. ||||.||...   |||.|||.| .. ||..|||. .||..| ..| ||...|        .||..|..| ..  .. .. .||| |.|||||||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

DYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKY
....| ..  |.  |.     |||.||||||||||||.|..|  |.| ..| .|.. |.. ..| ||  .||| .||.|||||.||||  .||.. ... 
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 801-1067 3.6e-85 280.5 In-house 14-278 (288) alignment 
Range on Protein: 801-1067
Range on HMM: 14-278/288.0
HVATCHSNGFDEQYENLSNP-HSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDmcEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIW
.      .|| |.|..|..  ..|  |.|.. .|   ||..||  || .|. ||  .. .  . .|||||||||. ...|.||.|||. .|. |||.|..
kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyidgekkkkkyiatqgPladtvndfWelvy

QEKPVSIVMVTNLKEGTKSKCEQYWPNKSE--EFGPFTVMLISQQVYPDFVIRQLNVKiqdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATW
..|   |||.|.| || |.|||.|||.. .  ..| .||.|....   ||| |.| ..    ...  ..|||. ..|||||||. ..||. | .||  . 
enktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvan

SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEA
.   |||.|||||||||||||||.| .... ..| ..|.||.|..||.||. .|||| ||.|.....|. 
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
0045450 (Phosphotyrosine protein) phosphatases II 809-1069 6.5e-85 280.8 In-house 28-305 (307) alignment 
Range on Protein: 809-1069
Range on HMM: 28-305/307.0
GFDEQYENLSNPH---SKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLdMCEREYINASYI--------DGYSSSNKFIASQGPMKKTLVDFWRL
|. ...| | . .   .  ..|... ||  .||.|.|  ||..|..|.. ..  . .  ||||||.        ||| ...|||| |||...|. ||||.
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrm

IWQEKPVSIVMVTNLKEGTKSKCEQYWPNK--SEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA
.|...   |||.|.|.| .. || ||||..  . ..|.||| |.| ........|.|.|.  ||.. |.|.|..| |.|||||||..  .| .. ..|..
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGV---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAII
   ..|..||.||||||||||||||||....|.| ..||.   ||.  .|..||.||...||...||.||..|.|| . 
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
DSPc_SM00195 810-1068 1.5e-84 278.8 In-house 2-262 (263) alignment 
Range on Protein: 810-1068
Range on HMM: 2-262/263.0
FDEQYENLSNPH-SKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLdmCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
..|..|.| .   .|..| .....|.  ||.||| .||..|..||....    . .||||.||.|.....|.|| |||...|. ||||..|.||   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEGTKSKCEQYWPNK---SEEFGPFTVMLISQQVYP-DFVIRQLNVKIQDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPI
.|. .|  | ||..|||..   .|.|| ..| |.... .. ....|.|... ..  ......|||. ..|||||||| ......| ..|  . | |.|||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAI
.|||||||||||||..|||.|.. ..|  |||  ||..||.||..|||||.|| |...|.||.|
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 810-1068 1.5e-84 278.8 In-house 2-262 (263) alignment 
Range on Protein: 810-1068
Range on HMM: 2-262/263.0
FDEQYENLSNPH-SKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLdmCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
..|..|.| .   .|..| .....|.  ||.||| .||..|..||....    . .||||.||.|.....|.|| |||...|. ||||..|.||   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEGTKSKCEQYWPNK---SEEFGPFTVMLISQQVYP-DFVIRQLNVKIQDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPI
.|. .|  | ||..|||..   .|.|| ..| |.... .. ....|.|... ..  ......|||. ..|||||||| ......| ..|  . | |.|||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAI
.|||||||||||||..|||.|.. ..|  |||  ||..||.||..|||||.|| |...|.||.|
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRA_pd Subfamily PTPRA 792-1103 3.4e-84 277.5 In-house 13-330 (330) alignment 
Range on Protein: 792-1103
Range on HMM: 13-330/330.0
PVSVDELGTHVAT---CHSNGFDEQYENLSN-PHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDmcEREYINASYIDGYSSSNKFIASQGPM
|. |..|   .       .. | |....|   |    . .  ..||   ||. ||  || .|.|| .    .  | .|||||.||||   .||||.||| 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaqGPk

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNK-SEEFGPFTVMLISQQVYPDFVIRQLNVK-IQDGS--NDSHTLTQYHLTSWPDHGVPDYA
..|. ||||.||. |  .|||.|.|||  ..||.||||.. .  .|  .| .  ..|  |. .|.. |. . |..  ..|  ..|.|.||||| |||  .
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

TPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTK
  ...| |.| ..   | ||| ||||||||||||||..|  ||. | |..||. ..|.|||.|| .||||. ||.|.. ..||  . |.|..     ...
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

LQELKEIDSSTGCSGLQSQF
||.|..  ..|   ||. .|
lqklynkitgtdkigleeef
subfamily_Ptp69D_pd Subfamily Ptp69D 795-1087 2.9e-83 274.5 In-house 6-305 (307) alignment 
Range on Protein: 795-1087
Range on HMM: 6-305/307.0
VDELGTHVATCHS---NGFDEQYENLS-NPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDMCerEYINASYIDGYSSSNKFIASQGPMKKT
.|.| . . . .     |. . ||.|  .  .| .......||   ||...|. .|..|..||. .  .    .|||||.| ||  ..||||.|.|.  |
iddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkeds..dYinasfikgykekkkfiaaqdPveat

LVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWP-NKSEEFGPFTVMLISQQVYPDFVIRQLNVKIQD----GSNDSHTLTQYHLTSWPDHGVPDYATP
. ||||.|.. .   |||..||.| .. ||..||| ..  ..|   | |.|..  .|..||.|.|  ..      .||. ..||| |.|.|  ||. |. 
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

LMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQ
|. | .||    . ...||.|||||||||.|.|.|.|. |.| | |  |||  .|  ||.||  .|| |.|||||. |.|. .  |.| .  |... ...
llklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie

EL
.|
rl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 805-1104 1.5e-81 268.6 In-house 16-313 (315) alignment 
Range on Protein: 805-1104
Range on HMM: 16-313/315.0
CHSNGFDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPnlDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPV
 |.  | |.. .| .|   | ...  ..|   ||.|||  .| .|..|.     |  ...||||||| .. . . .|||||| | .. ||||...|||. 
rhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevid..dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvt

SIVMVTNLKEGTKSKCEQYWPN---KSEEFGPFTVMLISQQVYPDFVIRQLnvkIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSK
.|||||...|| | || ||||.   .| ||| . | |.| .   | |.|.|   .   |..|.|.||...| |||.||.  .. |. | |.| |   . .
tivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkke

GPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQELKEIDSSTGCSGLQS
 ..|||||||||||| .|.||  ..|.||. .||.  .|. ||..|...||| ..| |..||||| .   .| |.  ..  .||.|.   . .| | .  
fsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtk

QFD
.|.
efe
Y_phosphatase Protein-tyrosine phosphatase 835-1066 6.1e-81 266.7 Pfam-A 3-235 (235) alignment 
Range on Protein: 835-1066
Range on HMM: 3-235/235.0
GFNRFKNITVYDDNRIILKPNPN-LDmcereYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWP---NKSEE
  ||.|.|..||..|. || ...  |     ||||.|..||....||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||   ..|..
kknRykdilpydktrvklkgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGPFTVMLI-SQQ-VYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQA
.| ..| |  ...    ....|.|..| ...........|.|.|.|||||||. ...|..| ..|  . ....||..|||||||||||||.|.||.|||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
..|. ||.  ||..||.||..|||.|.||.||..|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 835-1066 6.1e-81 266.7 In-house 3-235 (235) alignment 
Range on Protein: 835-1066
Range on HMM: 3-235/235.0
GFNRFKNITVYDDNRIILKPNPN-LDmcereYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWP---NKSEE
  ||.|.|..||..|. || ...  |     ||||.|..||....||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||   ..|..
kknRykdilpydktrvklkgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGPFTVMLI-SQQ-VYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQA
.| ..| |  ...    ....|.|..| ...........|.|.|.|||||||. ...|..| ..|  . ....||..|||||||||||||.|.||.|||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
..|. ||.  ||..||.||..|||.|.||.||..|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 827-1071 2.2e-80 264.5 In-house 3-245 (250) alignment 
Range on Protein: 827-1071
Range on HMM: 3-245/250.0
IGHRDENSGFNRFKNITVYDDNRIILKPNPNLDmcEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSkCEQYWP-
.... .|   ||. .|  .|  |..|...   .  | .|||||...||. .. |||.|||...|..||||....||  .|||.|||||  |  ..|||| 
vakkpqnkeknryadiialdssrvvLekekgdk..esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

NKSEEFGPFTVMLISQQVYPDFVIRQLNVKIQDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIA
.|.|..|  || | |.... |...|.| .  .   .|. .. |.| ..||| |||..||  . | |.| |.     ..|..|.|||||||.|.|||||  
ekaekyGdvtvsllskeefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

LEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICG
||..|.| |||.  ....||..|...|..|.||||.. ..|.|. . 
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
0040439 (Phosphotyrosine protein) phosphatases II 825-1068 1.5e-77 255.9 In-house 3-246 (249) alignment 
Range on Protein: 825-1068
Range on HMM: 3-246/249.0
CTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDMCEreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
...... ||   ||...|  || .|..|.. |.|  .   |||||||||| ....||| |||...|. ||||..|...  .|||.|.|.|  . ||.|||
ysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

P-NKSEEFGPFTVMLISQQVYPDFVIRQLNVKIQdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAI
| ..| |.| ||| |.| .|..|...|.| ..   . ..|.| .... |.|||||||..  .|... ..|.   .. |..||.||||||||||||||||.
plggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAI
...||| ..|. ||.  .|. ||.||...||...||.||..|.|| .
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 811-1071 1.7e-77 255.8 In-house 11-275 (278) alignment 
Range on Protein: 811-1071
Range on HMM: 11-275/278.0
DEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIIlkpnpnldmcerEYINASYIDGYssSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVT
 | ...|. ..  ..| . . .|  .||.|.|  || .|..            .||||||||||  ..|||| |||...|. ||||..|...  .|||.|
lefefllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlt

NLKEGTKSKCEQYWPNKS-EEFGPFTVMLISQQVYPDFVIRQLNVKIQ---DGSNDSHTLTQYHLTSWPDHGVPDYA--TPLMSLHKQVMATWS------
.|.|... ||.||||... ...|.||| |.| .|..|...| |.|      . .. |...|..|...|||||||..   ... .| ... .  .      
elvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasll

-------PSKGPILVHCSAGVGRTGTFIAIDIALEQAkrEGVVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDAVLEAIICG
       .|.||.|||||||||||||..|... ||.   ||.||.  .|. ||.||.  .||.|.||.||....|| . .|
lsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 806-1068 2e-76 251.8 In-house 13-276 (281) alignment 
Range on Protein: 806-1068
Range on HMM: 13-276/281.0
HSNGFDEQYENLSN-PHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDMCerEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPV
...|| |.||.|..   ..  |  ..|||   ||..||. ||  |. ..|| .  ..  .||||....||.. ...||.|||. ..||.||...|..|  
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenknt..DYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

SIVMVTNLKEGTKSKCEQYWPNKS--EEFGPFTVMLISQQVYPDFVIRQLNVkiQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPS-K
 |||||.  |. | || .|||...   ..| .||  ....  . .. |....  .  |... ...| . |.|||||||. .. |.. .|.|. . ... |
aivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk

GPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAI
 |...|||||||||||.||.| .......|   .|.  .|. ||..|. ||||. || |.. |||.|.
aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1177-1280 2.7e-75 247.9 In-house 194-297 (301) alignment 
Range on Protein: 1177-1280
Range on HMM: 194-297/301.0
DLTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
..||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
qvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

QMNS
|.||
qlns
0042113 (Phosphotyrosine protein) phosphatases II 825-1066 2.9e-75 248.1 In-house 1-241 (245) alignment 
Range on Protein: 825-1066
Range on HMM: 1-241/245.0
CTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDMCEreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
.... . ||  .||...|  ||..|..|.| ..   .   ||||||.|||  ..||||.|||...|. ||||..|...  .|||.|.. |  . ||.|||
ysvallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

P-NKSEEFGPFTVMLISQQVYPDFVIRQLNVKIqDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS-PSKGPILVHCSAGVGRTGTFIAID
| . | ..| ||| |.| ....|...|.|.|.  .|.. |.. ..|| ..||||||||.   | .... |    . .|.||.||||||||||||||||..
plgesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

IALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
..|||...|. |..  .| .||.||...|||..||.||..|.||
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN6_pd Subfamily PTPN6 794-1066 3.3e-75 247.9 In-house 12-295 (306) alignment 
Range on Protein: 794-1066
Range on HMM: 12-295/306.0
SVDELGTHVATCHSNGFDEQYENLSNP---HSKRCTIGHRDENSGFNRFKNITVYDDNRIILKpnpNLDMCEREYINASYIDG--YSSSNKFIASQGPMK
 |.||  .  . . .|| |..|.|..    .    . |.. ||   ||.|||  .|..|.|||   . .. . .||||.||..   .|....||.|| ..
rvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgcle

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNK--SEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPL
.|. ||||..|||.   |||.|.  | .|.|| .|||..  .||.|  .|. .|..   |...|.|.|. .. ....... ||| .||||||||     .
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgav

MSLHKQVMATWSPSK----GPILVHCSAGVGRTGTFIAIDIALEQAKREGV---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
... ..| .  . ..    |||.||||||.||||||| ||| |.. ...|.   .||  .|. .|.||  .||| .|| |.. |. .
LdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 806-1104 1.7e-73 242.5 In-house 21-324 (325) alignment 
Range on Protein: 806-1104
Range on HMM: 21-324/325.0
HSNGFDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNpnLDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLI--WQekp
  .||  ... | .  ..  ..  . ||   |||||.  .| .|..|.     |  . .||||||.  .   . |.|.| |. .|. |.|||.  |.   
dqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...

VSIVMVTNLKEGTKSKCEQYWPNK---SEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVM------
 |.|.|.|  .. | .| .|||..   | .||.. | |.. . . |.| |.|.||  ..  .. .. |..| ||.| ||. . . |.|. . |       
csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavserv

ATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQELKEIDSST
 . . . .||||||||||||||.||..  ||..   |  ||| | |..||..| .||.| |||.....|. ||...|.| .|   ...||  |.| .  |
tantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernplt

GCSGLQSQFD
    .. .|.
qklniekefe
subfamily_PTPN12_pd Subfamily PTPN12 824-1068 2.7e-73 241.4 In-house 31-277 (290) alignment 
Range on Protein: 824-1068
Range on HMM: 31-277/290.0
RCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDmcEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQY
. . |...||   ||.|.|  || .|. |. . . .  . .||||..| | ... ..||.|||. ||| ||||.||. .   .||. .. |  | |||.|
steagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerY

WPNKSE---EFGPFTVMLISQQVYP-DFVIRQLNVKIQdgsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFI
||.. |   |||.|.| |....    ||.||.|.|. |   ..|....|.| |.|||||||  |..|..| ..|  . . .. |..|||||||||||| |
WpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtii

AIDIALEQAKREGV---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAI
|||.. |. |.| .   .|.  .| .||.||  .||| .||.... ||.| .
aidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 808-1076 3.9e-73 240.8 In-house 9-274 (283) alignment 
Range on Protein: 808-1076
Range on HMM: 9-274/283.0
NGFDEQYENLSNPHSkRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNldmcerEYINASYID---GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPV
. | |....|| |.   ..|   |||  .||...| ..| .|. ||....      .||||..|     |  ..|.|..|.|...| ||||.....|| .
klfrevlkrlsvpdl.dadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

SIVMVTNLKEGTKSKCEQYWPNK-SEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGP
.|||.|.|.|. . || ||||.. ||..|.||| |  .     |.|..| .. .  ....  |. | .  | . |       |. . | .       |||
aivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgP

ILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIP
|.||||.|.|||..|||.  ....|. | |||.  .|. .|.||| .||||||| ..|..|||  .||.|.| 
ivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 829-1088 4.3e-73 241.4 In-house 57-311 (319) alignment 
Range on Protein: 829-1088
Range on HMM: 57-311/319.0
HRDENSGFNRFKNITVYDDNRIILKPNPNLDMCerEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNKS
  |.|   ||. ||  .| |.. |..    ..   .|||||...|| . .|.||.|||.. || ||||.||. .  .||..|      | || ||||.| 
nldqnkdknriinilafdknvvklerliGeefs..dyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki

E-EFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--WSPSKGPILVHCSAGVGRTGTFIAIDIAL
. . . | | . | .   ..|.|....  .   .|   .||.|.  |||.|||||...|| | |.|         . .|.|||||||||||..|..|. |
vikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvll

EQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQELK
.. |.|  ||.  .|. ||||| ..|| | || |.. |.||  . | . .    . . |.|| 
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels
0037934 (Phosphotyrosine protein) phosphatases II 825-1066 3.3e-72 238.2 In-house 2-240 (243) alignment 
Range on Protein: 825-1066
Range on HMM: 2-240/243.0
CTIGHRDENSGFNRFKNITVYDDNRIILkpnpnlDMceREYINASYIDGYsssNKFIASQGPMKKTLVD----FWRLIWQEKPVSIVMVTNLKEGTKSKC
..|... ||   ||...|  ||..|..|      .     ||||..|...   ...||.|||...|. |    |||..|...  .|||.|.|.| .. ||
fsiallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekc

EQYWPnKSEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--------WSPSKGPILVHCSAGV
.||||  ....|.||| |.|.....|...| | ..  | .. ... ..|| ..||||||||  ..|......| .           .|.||.||||||||
aqywp.gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTFIAIDIALEQAkreGvVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDAVLE
|||||.||... |..    | ||.  .|..||.||.  .|||..||.||..|.||
gRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 830-1087 4.7e-72 237.9 In-house 22-274 (284) alignment 
Range on Protein: 830-1087
Range on HMM: 22-274/284.0
RDENSGFNRFKNITVYDDNRIILKPNPNLDMCerEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNKSE
 |.|   ||. .|  .| |.. |..    ..   .|||||.| || . .|.||.|||.. || ||||.||. .  .||..|      | || ||||.| .
ldqnkdknrighilafdknvvklerliGeefs..dyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

-EFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALE
 . . | | . | .   ..|.|....  .   .|  ...|.|.  |||.|||||...|| | |.|    .    . .|.|||||||||||..|..|. |.
ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQEL
. |.|  ||.  .|. ||||| ..|| | || |.. |.||  . | . .    . . |.||
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
subfamily_PTPN9_pd Subfamily PTPN9 795-1066 1.3e-71 236.1 In-house 3-288 (297) alignment 
Range on Protein: 795-1066
Range on HMM: 3-288/297.0
VDELGTHVATCHSNGFDEQYENLSNPH-SKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDMCerEYINASYIDGYSSSNKFIASQGPMKKTLVD
..|| ..|   . .|  ..|... |   . . .  .   |.  ||....  ||. |. |.  .. ..   .||||...|||   . ||| |||.|||  |
ieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeas..dyinanfvdGykqkkafiatqGplkktvsd

FWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWP---NKSEEFGPFTVMLISQQVYPDFVIRQLNVKIQDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLH
|||..|... . |||.| . |  . || ||||   ..|.||| ..|  ...... |...|.|..|  .  ..| ..| . ..||||.|||. |. |. . 
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvl

KQVM-----------AT--WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
..|            ..    ||. ||.||||||.|||||||..||.|.. ...|.||.   |..||.||  ..|| .||.| . ||||
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 792-1080 1.7e-68 226.0 In-house 9-296 (297) alignment 
Range on Protein: 792-1080
Range on HMM: 9-296/297.0
PVSVDELGTHVATC-HSNGFDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPnlDMCEREYINASYIDGYSSsnKFIASQGPMKKT
|. . .. | | .  |.. | |..  | .   .  |  ..  |   .|.|||  || .|..|.     |  . .|.|||.. |.    ..|..| ||| |
piplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqmPmkat

LVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNKS-EEFGPFTVMLISQQVYPDFVIRQLNVKiQDGSNDSHTLTQYHLTSWPDHGVPD--YATPLM
. |||.....|..  |||.....|..| || .||..|.  .||  .|.| | .    |. |.|.|. .. .   . . ||. ..|||. |.    |. |.
vadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevt.kgkakarrvvkqyqfveWPdkaverkdsassll

SLHKQVMATWSPSKG-PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKY
 | ..|  ..|  .  |.||||.||||||| ...||  . .||||  ||| |.|..|||.|...||| .|| |.. |||||... .|.|... .
klisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 836-1065 3.5e-66 218.1 In-house 31-265 (274) alignment 
Range on Protein: 836-1065
Range on HMM: 31-265/274.0
FNRFKNITVYDDNRIILKPNPNLdMCEREYINASYIDGYSSSN-KFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEE----
 ||.|.|   .  |..|... .    . .|||| || ||.  .  ..| |||. .|. ||||.|.||.   |||.|.|||  ..||..|.|.. .     
knryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeise

-FGPFTVMLISQQVYPDFVIRQLNVKIQDGsndSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPS---KGPILVHCSAGVGRTGTFIAIDIALE
 .| . .   .     |. .|.| .| .     ..... |  |.|||| .|| |..|..| ..|  . . .    .|..||||||.|||| ||||.||. 
rygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavr

QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVL
| ..|.|||. .||  ||..|  |||| .|| ..| |. 
qlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 810-1083 4.3e-66 218.2 In-house 22-294 (439) alignment 
Range on Protein: 810-1083
Range on HMM: 22-294/439.0
FDEQYENLSNPH---SKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDmcEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSI
|.| .|...  .   .  ...  .. .   ||.|... .|  |..|.  | .      |||| ||.||   . .||.||| |.|  |||||....| | |
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvp..hshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

VMVTNLKEGTKskceqYWPNKSEEF-GPFTVMLISQQVYPDFVIRQLNVK-IQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV-MATWSPSKGP
||.||| |  |     ||| ..| . |  .|    .   |..||| ..|   .| ..  .|. |.| ..|||. ||  |. .. . . .  |  .   ||
vmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygp

ILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTK
..|||||||||||| ||.|||||| | |  ||| |||. ||.|| .|||.| ||||...|||| |. |.. .  |... .
vvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkke
subfamily_PTPN3_pd Subfamily PTPN3 821-1067 1.1e-65 216.4 In-house 29-274 (280) alignment 
Range on Protein: 821-1067
Range on HMM: 29-274/280.0
HSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNlDMCEREYINASyIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
 .  ... .. ||   ||...|. ||. |..|| ... |  . .|.|   |.. . .|..||.|||..||  |||...|..|   |||.|.| |  . ||
pglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnme.ipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

EQYWPNKSE--EFGPFTVMLISQQVYPDFVIRQLNVKIQDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTF
 ||||....  |.| |.|.. ...    .|.|.| .| .. ........|   ..|||||||| .. .... ..| .. | .. |..||||||.|||| .
hqyWPetedeleygefsvkcekedetksyvlrelvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvl

IAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEA
|....||    ..  | .  || ..|.||. .||| .|| |. .|.|..
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 833-1067 2.1e-65 215.2 In-house 7-239 (239) alignment 
Range on Protein: 833-1067
Range on HMM: 7-239/239.0
NSGFNRFKNITVYDDNRIILKPNPNldMCEREYINASYIDGYSSSNK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEEF
|   ||. ||  || .|..|.   |      .||||||.  |  | | .||.|| .. .  ||||..|||. . |||.| | || | || ||||. . ..
nkaknryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

GPFTVMLISQQVYPDFVIRQLnVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRE
  . | |   .|. |..|| . |  | |  . . . |||.| |||.|||.||| .. |....     |   | ..||||||||||.|. ||  | |||..
cnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEA
  |||   |. .|..| .|||| .||||.| |||||
ktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 833-1066 7.9e-65 213.3 In-house 8-239 (239) alignment 
Range on Protein: 833-1066
Range on HMM: 8-239/239.0
NSGFNRFKNITVYDDNRIILKPNPNldMCEREYINASYIDGYSSSNK-FIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEEF
|   ||. ||  || .|..|.   |      .||||||.  |  | | .||.|| .. .  ||||..|||. . |||.| | || | || ||||. . ..
nkaknryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

GPFTVMLISQQVYPDFVIRQLnVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRE
  . | |   .|. |..|| . |  | |  . . . |||.| |||.|||.||| .. |....     |   | ..||||||||||.|. ||  | |||..
cnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
  |||   |. .|..| .|||| .||||.| ||||
ktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN13_pd Subfamily PTPN13 811-1068 3.4e-64 211.7 In-house 14-269 (273) alignment 
Range on Protein: 811-1068
Range on HMM: 14-269/273.0
DEQYENLSNPHS-KRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNldmcereYINASYIDGYSSSNKF--IASQGPMKKTLVDFWRLIWQEKPVSIV
.|....| . .. ..|..|...||   ||..|.  ||. |..|. . .       |||||.|      ...  ||.|||. .|  |||...|. |   |.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MVTNLKEGTKSKCEQYWPNKSEE----FGPFTVMLISQQVYPDFVIRQLNVKIQDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQvMATWSPSKGP
|||. ||. | ||..|||.. ..     . ..| |. .| . .||.|.|.|| .. |..|. ... ....|||||||  |..|. . .. ...   ..||
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse.sgesrevahlnfvkwPdhgvPssaaellqfvae.vrrlqtdagP

ILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAI
|.||||||.||.||.|.||..|.  .|.  .|.  ||..||.||  .||| |||.| . |.||..
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 833-1066 4.4e-63 207.7 In-house 3-237 (237) alignment 
Range on Protein: 833-1066
Range on HMM: 3-237/237.0
NSGFNRFKNITVYDDNRIILKPNPNLdmceREYINASYIDGYSSS-NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN--KSE
|   ||. ||..|| .|..|| . .      .||||.|..|.  . .|.||.|||.. .  |||...||||   |||.| | || . || .|||.  . .
nkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

EFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--WSPSKGPILVHCSAGVGRTGTFIAIDIALEQ
 .| .|| |  .. . |. .| | .  .   ..   . ||..|||||.|||.... |. . |...      .  || ..|||||||||| |. ||  | |
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

AKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
|| . ||||   |  . ..|  ..|| |||||.|...||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 817-1066 3.1e-62 205.0 In-house 4-262 (270) alignment 
Range on Protein: 817-1066
Range on HMM: 4-262/270.0
LSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNldMCEREYINASYIDGYSSS-NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEG
|.. .... .. .   .. .||...|      |..|..  .    . .|||| |. |.... .|.||..||.. || .|||.||.||  .|||.|.|.| 
ldkeetsesdlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEk

TKSKCEQYWPNKSEE-----FGPFTVMLISQQVYPDFVIRQLNVKiQDGSndSHTLTQYHLTSWPDHGVPDYAT------PLMSLHKQVMATWSP-SK-G
 ..|||.|||....|     .|  .|. .|..    .....|... ..|.  .. |. .. ..|||||||  .        |... ..| .. .  .| .
grkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
|.|||||||||||||.||.|||..  .... ||.. |...||..||..||. .|| ||. ||.|
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 804-1089 1.7e-61 202.8 In-house 16-257 (392) alignment 
Range on Protein: 804-1089
Range on HMM: 16-257/392.0
TCHSNGFDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPnpNLDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKP
  ||  | |.. .| .|.  . |..... |   ||.|||  || .|..|.     |. ...|.|||||... . . .||||||   .| ||||...||..
nrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklev..iddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenv

VSIVMVTNLKEGTkskceqywpnkseefgpftvmlisqqvypdfvirqlnvkiqdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGP
 .|.|||.||||                                             .| .| .|.|.| |||..|| ... |. . |.| | .     |
ttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythp

ILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQELKE
...||||||||||  |.||  . .||.  .||.  .|  .|..|  |||| .|| |.. |||| ..  .| ||  ..  .||.|. 
liihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst
subfamily_CG7180_pd Subfamily CG7180 812-1073 3.4e-59 194.9 In-house 21-295 (296) alignment 
Range on Protein: 812-1073
Range on HMM: 21-295/296.0
EQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLDMCEreYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTN
 ...  .. ..  |  |.| || . ||  ..  || ||..|.     .  .  ||||.|.|..   ...|  ..|.|.|. .||||...|.  ..|..|.
lelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtk

LKEGTKsKCEQYWPNK-SEEFGPFTVMLISQQVYPDFVIRQLNVKIQ---------DGSNDSHTLTQYHLTSWPD-HGVPDYATPLMSLHKQVMA---TW
  . .| .. .|||||  |..|.. | ..... |....||.. .. .         . . .  ......|| |.  . ||  .. |. | ..|       
tfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv

--SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGET
   | .||..|..| |..|.| ..|||..||....|. ||. . | .||..| ..|.. ..| .. | .|||..|. .
dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_PTPN23_pd Subfamily PTPN23 810-1067 1.1e-56 186.8 In-house 17-279 (288) alignment 
Range on Protein: 810-1067
Range on HMM: 17-279/288.0
FDEQYENLSN---PHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKpnpnldMCEREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPVS
.|.....| .    ...  .|     .|  ||...|  || ||. |.        . .|||||.. . |. . .|||.|.|...|| |||......|   
ldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMVTNLKEGTKSKCEQYWPNKS---EEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA----TWS
|||... .|  | |...|||..    ..||...| | |..  . .| |.|.....| .   ....  .|||||..|||.    |. . ..| .    .  
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqr

PSKGPILVHCSAGVGRTGTFIAIDIAL-EQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEA
.|| |..|||||||||||.|  .  |. |  |..|..||  .|.|||.||  |||. .|. |. .|||||
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0051429 (Phosphotyrosine protein) phosphatases II 864-1088 8.1e-56 184.9 In-house 5-244 (272) alignment 
Range on Protein: 864-1088
Range on HMM: 5-244/272.0
EYINASYIDGYSS---SNKFIASQGPMKKTLVDFWRLiWQEKPVSIVMVTNLKEGTKSKCEQYWP-------------NKSEEFGPFTVMLISQQVYPDF
 ||||....|| .    .....|.||.. |  ||||| ....  .||..... |  . ||..|||               . ..| ..|.|.| ....|.
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYAtpLMSLHKQVMAtwspsKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVD--------IAGI
..| | .... . .........| |.|||||||. |  | .| ... .     .||.|||||||..||||..|... |..  .| .||        ....
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VNRLRQQRMKMVQTLDQYVFLHDAVLEAiICGETKIPTDKYQTKLQELK
|..||.||...||| .||.||..|.||. ... . .. . ... |....
veelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid
subfamily_PTPRN_pd Subfamily PTPRN 811-1067 1.4e-55 183.1 In-house 32-291 (297) alignment 
Range on Protein: 811-1067
Range on HMM: 32-291/297.0
DEQYENLSNPHSKRCT--IGHRDENSGFNRFKNITVYDDNRIILKPNPNLDmcEREYINASYID-GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
....| | . ... .|  ......|   || |..  ||..|. || . . .  . .||||| |      .  .||.|||. .|. |||...|..  | ||
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasae..ksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

MVTNLKEGTKSKCEQYWPNKS-EEFGPFTVMLISQQVYP-DFVIRQLNVKIQDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPIL
..|.|.|   ..|..|||..  | .. . | |.|. ..  |...| . .|  . .... |.||.|  |||..|||  | .|. . ..|  ..     ||.
nltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpiv

VHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEA
||||.|.||||..|.||. |.. ..    .|||  .. ||.|| ..|.| ||. |   || | 
vhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_PTPN1_pd Subfamily PTPN1 821-1073 1.1e-54 180.1 In-house 20-278 (290) alignment 
Range on Protein: 821-1073
Range on HMM: 20-278/290.0
HSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNldmcerEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
.  ...  ...|| . ||..... ||  ||.|. . |      .||||| ..      ..| .|||. .|   ||...|..|  ..||. .. |  . ||
sdfptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

EQYWPNKSE----EFG--PFTVMLISQQVYPDFVIRQLNVKIQdGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGV
 ||||.. |    ..    ..| |||....  ...|.|... .  ..........| |.||| |||.  . ....  .|    . |. .|| ..|||||.
aqywPqgeeekellledtklkvkliseerksyytvrllelenl.ktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRTGTFIAIDIALEQAKRE---GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIIC--GET
||.|||. .|  | . ...     |||   .  ||..|. ..|| ||  | . |.|| . .  |..
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgds
subfamily_PTPN14_pd Subfamily PTPN14 814-1067 5.1e-54 178.3 In-house 29-295 (300) alignment 
Range on Protein: 814-1067
Range on HMM: 29-295/300.0
YENLSNP-HSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNLdmcEREYINASYIDGYSSS--NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVT
||....  .   .. .. .||   ||||..  |.|||. |.|. .    . .||||| |    ..   ..|..|||...|. |||...|...   |||.|
yeripkkredallstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NLKEGTKSKCEQYWPNK-----SEEFGPFTVMLISQQVYPDFVIRQLNVKIQDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSL-------HKQVMATWS
. .|. | |. .|.|..     . ||| | |.   ..  . .. ..|..|    |..  |.     | |||||||.  .. .|         ...  . .
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

--PSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEA
   || |.||||||||||||  |  |. ..  . . ..||  ...|||.||| .|||| || |....... 
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 835-1065 1.5e-52 173.2 In-house 40-274 (287) alignment 
Range on Protein: 835-1065
Range on HMM: 40-274/287.0
GFNRFKNITVYDDNRIILKPNPNLDMcerEYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSE--EFG
  ||. ..  .||.|..|  ...|     .|||| |. .|   ..|||.|||.  |. ||||......  |....|   | .. || .|||..      |
kknryadvlPiddtrvllsaegelGs...dyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

PFTVMLISQQV-YPDFVIRQLNVKIQDGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV-----MATWSPSKGPILVHCSAGVGRTGTFIAIDIALE
 ..|.|.....  |.. .| | .   .. .... . |..| ||||....  |  |. .  .|     .|  .   ||..||...|.||.|...|. . ..
GysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVL
. .  | ||.| .| |||..|  .||.  |. .| .|. 
rledlGrvdvaavvirlreyraalvqavvqlrllyealv
0041856 (Phosphotyrosine protein) phosphatases II 833-1074 5.2e-50 164.9 In-house 1-177 (182) alignment 
Range on Protein: 833-1074
Range on HMM: 1-177/182.0
NSGFNRFKNITVYDDNRiilkpnpnldmcEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtkskCEQYWPnkseefg
|   ||...|  || .|               ||||....|.  ...||| |||...|. ||.|......  .||..|         .|.|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

pftvmlisqqvypdfvirqlnvkiqdgSNDSHTLTQYHLTSWPDHGVPDyATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDIALEQakreG
                           ..  .. .||. ..||||||||    | .. ..| .    ..||.|||||||||||||..|... ...    |
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g

vVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETK
 |..  .|. .|..|..||.|..||.||..|.|| . ...| 
.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
0036282 (Phosphotyrosine protein) phosphatases II 864-1062 1.7e-47 156.7 In-house 3-164 (174) alignment 
Range on Protein: 864-1062
Range on HMM: 3-164/174.0
EYINASYIDGYSSSNKFIASQGPMKktlvdFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNkseefgpftvmlisqqvypdfvirqlnvkiqDGSNDS
 |||||..|..  ....||.|||..     ||.......  ..||....||  . || .|||                                . .  .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredle

HTLTQYHLTSWPDHGVPDYATpLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIALEQAKrEGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
..  ||. . |||||||| .. | .. |.|    |  ..||.|||||||||||||..|... | . . |..||.  .| .||.||..|||| .|| ||..
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 831-1066 5.1e-47 154.9 In-house 52-281 (290) alignment 
Range on Protein: 831-1066
Range on HMM: 52-281/290.0
DENS--GFNRFKNITVYDDNRIILKpnpnlDMCEREYINASYIDGYSssNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKS
|.|.    ||.|...  |  |.|||     |  . .|. | |..|      || .||..|.| .|.||.. |||   |||. .| |  |.|||||.|.|.
dkntefkknrykdvvcndktrvilk.....dGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke

EE---FGPFTVMLiSQQVYPDFVI--RQLNVKiQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDI
 |   || .||.  |..  .|  |  . | |. .  |  .| |  ... ||||. |.  .  |. . . .        ||. ||||||.||||||.||..
GevltfGeitvlc.seeddkdaniikktlsvr.dkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaiev

ALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
.|.       .|....|  ||. |.. ||   ||. | ...|.
glqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 813-1066 1.8e-46 153.3 In-house 14-257 (267) alignment 
Range on Protein: 813-1066
Range on HMM: 14-257/267.0
QYENLSNPHSKrCTIGHRDENSGFNRFKNITVYDDNRIILKPNpnldmcEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNL
. ...|. .|. ..     .|  .||. .   |||.|.||. .      |.|||||||..||   |.||. |.|.|.|  ||. .| ..|   ||..|. 
likkisdtsst.isqsiaeknqernrlddnlpyddtrvilrtk......eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv

KEGtksKCEQYWPNK---SEEFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNdsHTLTQYHLTSWPD-HGVPDYATPLMSLHKQvmATWSPSKGPILVHC
 ..   .  ..|| |   ....  .||    ..   |. |  |..|... |   | .| |.   |        |  ||. .  .          |..|.|
ftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa..hnvtlyyykkwnintnnkpylkplfgilak..nqlengnrPlvvac

SAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
|.||||.|||. ||  ||.||.|||.||   . ..|.||. .|.|...|...|. . |
sdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1178-1277 4.1e-43 142.7 In-house 185-284 (305) alignment 
Range on Protein: 1178-1277
Range on HMM: 185-284/305.0
LTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
|||||..||.... ..|..|..| ..|.|  | |..||||..|.|.||...|.| ||..|.|.|||||.|.|..|......|.||.||....|..| ...
ltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
0050432 (Phosphotyrosine protein) phosphatases II 1075-1277 5.3e-43 142.9 In-house 20-300 (308) alignment 
Range on Protein: 1075-1277
Range on HMM: 20-300/308.0
IPTDKYQTKLQELKEIDSSTGCSGLQSQFDLLSQVTPdPDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQEANGYINASFISGF--HEKRAFIIAQSPME
 ....... |. || ... .. ..|. .|  | .|.| . . ..   ..   |||.. .|| .   | |.| ..|||||...|.  . .|.||..|.|..
lvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlp

NTARDL--------------------------------------------------------------------------------TDWPQDGVVREPRT
||  |                                                                                 |.|| .||  .|. 
ntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspei

VLQVIDDVIHRQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.|. .. | ...   .|||.|||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|.|||  .|... .||.
lldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0043147 (Phosphotyrosine protein) phosphatases II 863-1061 1.1e-42 141.0 In-house 5-154 (172) alignment 
Range on Protein: 863-1061
Range on HMM: 5-154/172.0
REYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLkegtkskceqywpnkseefgpftvmlisqqvypdfvirqlnvkIQDGSND
. ||||||.|.|   ..||| |||.  || ||||......   ||..|.|                                             |... 
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpell

SHTLTQYHLTSWPDHGVPdYATPLMSLHKQVMA-TWSPSKGPILVHCSAGVGRTGTFIAIDIALeqakreG-VvDIAGIVNRLRQQRMKMVQTLDQYVFL
...  ||. ..|||||||  .  |... ...       ..||.|||||||||||||..|... |        . ..  .|. .|..|...||. .|| ||
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrfl

H
.
y
0049260 (Phosphotyrosine protein) phosphatases II 870-1062 3.4e-42 139.0 In-house 1-144 (152) alignment 
Range on Protein: 870-1062
Range on HMM: 1-144/152.0
YIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWpnkseefgpftvmlisqqvypdfvirqlnvkiqdgsndshtltQY
.||||  ...||| |||.  || ||||.... .   |||.|.| | .| |||||.                                           ||
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALeqakreGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
. . |||||||| .  |. |.. .   .  ..||.|||||||||||||..|... |        |..  .|...|..|...|.. .|. ||..
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 864-1066 3.6e-42 139.4 In-house 13-171 (176) alignment 
Range on Protein: 864-1066
Range on HMM: 13-171/176.0
EYINASYIDGYsssnKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNkSEEFGPftvmlisqqvypdfvirqlnvkiqdgsnds
 ||||..|.|.    ..|| |||. .|| ||........   .|..|...|  . || .|||   |..|                               
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi..............................

htltQYHLTSWPDHGVPDYaTPLMSLHKQVMAtWSPSKGPILVHCSAGVGRTGTFIAIDialeQAKREGVVDIAGIVNRLRQQRM-KMVQTLDQYVFLHD
    ||. . ||||||||. . |..| ...   .  ..||.|||||||.|||||..|..      ..|  ...  .. ..|.||. ..||| .|| ||..
....qylhlpwpDhgvpdl.elllellefire.alkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflye

AVLE
..|.
fell
0049772 (Phosphotyrosine protein) phosphatases II 816-1067 3.8e-42 140.5 In-house 29-279 (314) alignment 
Range on Protein: 816-1067
Range on HMM: 29-279/314.0
NLSNPHSKRCTIGHRDENSGFNRFKNITVYDdNRIILkpnPNLDMCEREYINASYIDGYsssNKFIASQGPMKKTLVDF----------WRLI--WQEKP
.|| . .. ....   .|   ||...|  .| || ||   |.|..    ||||||.||.   .||||.|||.. |.|||          ||..  .. ..
slsvlpeltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnv

VSIVM---------------------VTNLKEGTKSKCEQYWPNKSeefgpftvmlisqQVY--PDFVirqlnvkiqdgsndSHTLTQYHLTSWPDHGVP
  |||                      ..| ...   .......               ...  |...              ...  .|. . .||...|
rdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk.............eelydpelf..............erlgikylripvpDgsap

DYATPLMSLhkQVMATWsPSKGPILVHCSAGVGRTGTFIAIDIALEQAkreGVvDIAGIVNRLRQQRM-----KMVQTLDQYVFLHDAVLEA
. .  .  |  ... .. . .||.||||.||.||||||..... . .    || ... .....|..|.      ....|.||.| ..|.||.
lledfdefl..efieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealley
0051299 (Phosphotyrosine protein) phosphatases II 1072-1276 4.7e-42 139.8 In-house 2-286 (288) alignment 
Range on Protein: 1072-1276
Range on HMM: 2-286/288.0
ETKIPTDKYQTKLQELKeidsSTGCSGLQSQFDLLSQVTPDpDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQ-----EANGYINASFISGFHEKRAFII
.| |.....   ...|.     .| .||. .|. | ...||  .. .   ...  |||.| .|| .   | |.     | ..|||||.|.|.. ||.||.
dteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

AQSPMENTARD---------------------------------------------------------------------------------LTDWPQDG
.| |..||  |                                                                                  |.|| .|
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

VVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|   |. .|. . .|.. ..  ||||||||||. |.|.|... . . ||| ..||.|||... | .|. .||.|.|.|||  .|... .||
vpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 813-1068 5.2e-41 135.6 In-house 21-277 (307) alignment 
Range on Protein: 813-1068
Range on HMM: 21-277/307.0
QYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKpnpnLDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNL
....|..   .  |.   . |.  ||.... . | .||..|    .|    .|| | |.      .|||..|||...|  .|| .. |||  |..|. ..
efrvlakktpegvtveafsantdknryqdvkcqdkgrivvk....fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckv

KEGTKSKCEQYWPNKSEE---FG--PFTVM---LISQQVYPDF-VIRQLNVKIQDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGP
 | .| ||||||| .  .   ||  | |.    | .... ||  .|   ..|..  ...| |....  . |||.|||.     . | . |       . |
ielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltainlleav....rydtnp

ILVHCSAGVGRTGTFIAIDIALEQA-KREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAI
..|||||||||.|| .|| .  ..  . .   |.  .|. ||.||   .||  ||..||  .||  
vvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 832-1066 1.2e-40 134.2 In-house 47-285 (305) alignment 
Range on Protein: 832-1066
Range on HMM: 47-285/305.0
ENSGFNRFKNITVYDDNRIILKPNpnldmCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEEF
...| ||.|..   |.||. |..         ||| | |.   . ...|| .| |..||  ||| . .|.|  .| |. ||.|    || .|.. | .. 
qeagknrykdvgcldnnrvklegp.....wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

GPF-------TVMLISQQV-----YPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGPILVHCSAGVGRTGTFI
  |       .| . | .        . ....  . |.   ....  |.||   ||| |||   . .. | ..      |||||| ||||||.||||. .
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvv

AIDIALEQAKREGVV-DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
 ..  |.|     .. |   |....|.|| . .|| .||.|.|. .|.
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 809-1066 2.4e-40 132.9 In-house 12-267 (281) alignment 
Range on Protein: 809-1066
Range on HMM: 12-267/281.0
GFDEQYENLS-NPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKP-NPNLDmcEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSI
 | ... ||  .| |  ||.  .  |   ||. || . |  |. ||   || .    .|| | ||        .| .||| |.|  ||||.||||.  .|
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnkn..stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMVTNLKEGTKSKCEQYWPNKSE---EFGPFTVMLISQQVYPDFVIRQLNVKIQdGsnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPskgp
||. .. |  . || .|.| ..    .|  ..|      |   .|  .||.  . |  ... .|..    |||  ||. .  .. . ... |  .|    
vmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye.g..etrlithwlwkewpdwqvpessevmlkilrkirarstp....

ILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIVNRLRQ-QRMKMVQTLDQYVFLHDAVLE
 ..||||||||.||..|..|||.  .    . ||  || .||   |   ||||.||...   .|.
pvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0046845 (Phosphotyrosine protein) phosphatases II 1098-1277 3.5e-40 133.6 In-house 1-275 (284) alignment 
Range on Protein: 1098-1277
Range on HMM: 1-275/284.0
GLQSQFDLLSQVTPDPD-DVFTNTAKAYPAKNRSSKFLPVELFLVPLQ------EANGYINASFISGF-----HEKRAFIIAQSPMENTARD--------
||. .|  | ..|...  .. .  ....  |||.. .|| .   | |.      | ..|||||...|.     . |..||..| |..||  |        
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

-----------------------------------------------------------------------LTDWPQDGVVREPRTVLQVIDDVIHRQQK
                                                                        |.|| .||  .|. .|. ...| . ...
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
  ||||.|||||. |.|.|... . . ||| ..||   .|||... | .|. .||.|.|||||  .|... .||.
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0039614 (Phosphotyrosine protein) phosphatases II 1082-1278 2e-39 131.2 In-house 17-291 (297) alignment 
Range on Protein: 1082-1278
Range on HMM: 17-291/297.0
TKLQELKEIDSSTGCSGLQSQFDLLSQVTPDpddVFTNTAKAYPAKNRSSKFLPVELFLVPLQEANG------YINASFISGFHE-KRAFIIAQSPMENT
. |  |. ..  .....|. .|  | ...||     .   ..   |||.. .|| .   | |.  .|      |||||...|..  .|.||..| |...|
svldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

ARD-------------------------------------------------------------------------LTDWPQDGVVREPRTVLQVIDDVI
  |                                                                          |.|| .||   ....|.... | 
vedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvr

HRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
.....  .||||.||||. |.|.|...   . |||.. || |||... | .|. .||||.|..||  .||.. ..|. 
ealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0047943 (Phosphotyrosine protein) phosphatases II 1088-1276 9.6e-39 128.9 In-house 3-272 (273) alignment 
Range on Protein: 1088-1276
Range on HMM: 3-272/273.0
KEIDSSTGCSGLQSQFDLLSQVTPdPDDVFTNTAKAYPAKNRSSKFLPVELFLVPL-QEANGYINASFISGFHEKRAFIIAQSPMENTARDL--------
. .....| ..|. .|.|| ...| . .  .   ...  |||.. .||..   | | .. ..|||||...|.. ||.||..| |..||  |         
lllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

------------------------------------------------------------------------TDWPQDGVVREPRTVLQVIDDVIHRQQK
                                                                        |.|| .||   .  .|. |..| . ...
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

I-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
. ..||||||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|.|||  .|... .||
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 1087-1277 1.6e-38 128.1 In-house 3-278 (297) alignment 
Range on Protein: 1087-1277
Range on HMM: 3-278/297.0
LKEIDSSTGCSGLQSQFDLLSQVTPdPDDVFTNTAKAYPAKNRSSKFLPVELFLVPLqEANG--YINASFISGFHEKRAFIIAQSPMENTARDL------
|| ...... ..|...|. | .. . . .  .   ...  |||.. .|| .   | | . .|  |||||...|.. ||.||..| |..||  |       
lkllekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

---------------------------------------------------------------------------TDWPQDGVVREPRTVLQVIDDVIHR
                                                                           |.|| .||   |...|. |. | ..
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

QQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.... .||||.||||. |.|||... . . |.| .    || ||.... | .|. .||||.|||||  .|... ..|.
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 823-1070 1.7e-38 127.2 In-house 25-272 (285) alignment 
Range on Protein: 823-1070
Range on HMM: 25-272/285.0
KRCTIGHRDENSGFNRFKNITVYDDNRIILKpnpNLdmcEREYINASYIDGYS-SSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCE
  ||    . |  .||. .. . .. |..||   |    .|.|| ||..       . .|..|||. .|| |||..|.|||   ..|.  | ||   || 
pnctytayeanpdlnryadvrcieetrvvlk...nh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekca

QYWPNKSEE---FGPFTVMLI--SQQVYPDFVIRQLNV-KIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtWSPSKGPILVHCSAGVGRT
 |.|.|  |   || . . |    ..     ..  | | . .| |..   . . ..  |||.  |. | |.. |.| |     | . || ||||||||||
lyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrt

GTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIIC
 ||. || |  .   .  ...  ||  .|  |.. ||.  |..||.  ..| .| 
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig
0040438 (Phosphotyrosine protein) phosphatases II 1097-1277 3e-37 124.0 In-house 18-277 (317) alignment 
Range on Protein: 1097-1277
Range on HMM: 18-277/317.0
SGLQSQFDLLSQVTPDpdDVFTNTAKAYPAKNRSSKFLPVELFLVPLQEAN-----GYINASFISGFHEKRAFIIAQSPMENTARD--------------
 .|...|  | ....|  .  .   .. . |||.. .|| .   | |.  .     .|||||...|...||.||..|.|..||  |              
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

---------------------------------------------------------------LTDWPQDGVVREPRTVLQVIDDVIHRQQkiG-GGPVV
                                                                |.|| .||   |...|. .. | . ..  . ||||.
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvl

VHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
||||. |.|.|... . . |||.. || |||... | .|. .||||.|.|||  .||.. .||.
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 807-1070 3.1e-37 123.2 In-house 18-273 (288) alignment 
Range on Protein: 807-1070
Range on HMM: 18-273/288.0
SNGFDEQYENLSNPHSKRCtIGHRDENSGFNRFKNITVYDDNRIILKpnpnlDMCEReYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSI
 .| . .|..  |  |..  |    .|.  .|..|.   |  |. |.     | ..  ||.|  .      ...| .| |.. |.  .|... ..    |
veglkkeyrdspneasidi.idsfianptrdryenlprcditrvkls.....ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyi

VMVTNLKEGTKSKCEQYWPNKSE---EFGPFTVMLISQQVYPDFVIRQLNVKIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGP
||...| |  | | ..|.| |      .| .  .   ...  | ...   ..|.   ...  . . ||  |.|.|||.   . . | . .       . |
vmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkP

ILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIIC
|.||.|||||||||.| | ||||... .  . |  ....||..|.| .||  ||...|  ||| .. 
ivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
0045450 (Phosphotyrosine protein) phosphatases II 1083-1276 4.2e-37 123.9 In-house 13-304 (307) alignment 
Range on Protein: 1083-1276
Range on HMM: 13-304/307.0
KLQELKEIDSSTGCSGLQSQFDLLSQVTPD-PDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQ------EANGYINASFI--------SGFHEKRAFIIA
||  |. ..  .. .||. .|  | .||.. ...  .   ..   |||.. .|| .   | |.      | ..|||||..        .|.. ||.||..
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QSPMENTARDL-------------------------------------------------------------------------------TDWPQDGVVR
|.|...|  |                                                                                |.|| .||  
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

EPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 . ..|. |. | . ...  .||||.||||. |.|.|...   . |.| ..||.   ||.... | .|. .||||...|||  .|... ..|
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 1092-1276 9.7e-37 122.3 In-house 15-277 (278) alignment 
Range on Protein: 1092-1276
Range on HMM: 15-277/278.0
SSTGCSGLQSQFDLLSQVTPdpDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQE-----ANGYINASFISGFHEKRAFIIAQSPMENTARDL--------
  .....|. .|  | ....  |.  .   ..   |||.. .|| .  .| |.       ..|||||...|.. .|.||..| |...|  |         
llnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

--------------------------------------------------------------------TDWPQDGVVREPRTVLQVIDDVIHRQQkIGGG
                                                                    ..|| .||   . ..|. . .|.....   .|
vttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsng

PVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
||.||||. |.|.|... . . ||| . || ||.... | .|. .||||.|..||  .|... .||
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0051082 (Phosphotyrosine protein) phosphatases II 864-1065 9.9e-37 121.2 In-house 4-150 (151) alignment 
Range on Protein: 864-1065
Range on HMM: 4-150/151.0
EYINASYIDGYsssnkFIASQGPMKktlvDFWRLIWQEKPVSIVMVTNLKEGTksKCEQYWPNKSeefgpftvmlisqqvypdfvirqlnvkiqdgsnds
 |||.||..|.     ...|.||.     ||..|.....  .||......|    .| .|.|. .                                   
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

HTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwsPSKGPILVHCSAGVGRTGTFIAIDIALEQakregvVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
..........|||.|.|..   ..........   ...||.|||||||.|||||..|... |..      |... ... .|..|. .||. .|..|.. |
ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa

VL
.|
ll
0044763 (Phosphotyrosine protein) phosphatases II 846-1064 2.4e-36 120.4 In-house 3-167 (178) alignment 
Range on Protein: 846-1064
Range on HMM: 3-167/178.0
DDNRIILKPNPNLDMceREYINASYIDGYsssnKFIASQGPmkktlVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEefgpftvmlisqqvyp
|..| .| . ..| .   .|||||.|...     ...|..|     .|...|.....  .||..|. .|. . || .||| . .                
drtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

dfvirqlnvkiqdgsndshtlTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQakreGVvDIAGIVNRLRQ
                      ||. . .|||||||    .. ... . .  ....||.||||||||||.||..|... ...    |. ..  .....|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvre

QRMkMVQTLDQYVFLHDAV
.|. .|.. .|. .|..  
rRp.ivpnpgqlrqLyefe
PTPc_DSPc_SM00012 966-1066 8.1e-36 117.8 In-house 2-105 (105) alignment 
Range on Protein: 966-1066
Range on HMM: 2-105/105.0
LTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSK--GPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
...|| |.|||||||........| ..|.   . |.  .|..|||||||||||||.|.||.|.| ..| . |||  ||..||.||..||||..||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
subfamily_ptpA1_pd Subfamily ptpA1 824-1025 2.9e-34 113.5 In-house 38-253 (418) alignment 
Range on Protein: 824-1025
Range on HMM: 38-253/418.0
RCTIGHRDENSGFNRFKNITVYDDNRIILKPNpnLDMCEREYINASYIDGYsSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQY
  . | .  |.  ||. ||   .  |. ||     |    .|||| ||||    ..||..|||. .|. ||||..|...   |||..   |  . ||..|
etsegdkkhntsknrytnilpvnhtrvqlkki..qdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdry

WPN------------KSEEFGPFTVMLISQQVYPDFVIRQLNVKIQDgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVM------ATWSPSKGPIL
||.              | || ..| |.     |.  |   |...     ... .|||.   |||| .||.. |.  | . .          |  . ||.
wpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf.egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VHCSAGVGRTGTFIAIDIAL
||||||||||||| .  | .
vhcsagvgrtgtfctavimm
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 834-1068 2.9e-34 113.1 In-house 56-289 (305) alignment 
Range on Protein: 834-1068
Range on HMM: 56-289/305.0
SGFNRFKNITVYDDNRIILKPNPnldMCerEYINASYIDGYS-SSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEEFG
   ||.... . | . . |.  .    .  .|| | |.       ..||..|||. .|. .|| .. |.|   |||. .  |  | || ||||    |  
itknryqdvpcqdqsavkldkps...ps..dyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

PFTVMLISQQV--------YPDFVIRQLNVKIQdgSNDSHTLTQYHLTSWPDHGVPDYAtpLMSLhkQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIA
 .   .. ..|         ..  |  ||.      ... .. . . | ||| |||     | ||  .....   || ||.||||||.||||| .||.  
elksgivvenvsgskpmerdaeiqitllnltys..gdqkmsvrhlqwtewpdrgvppck..ltsl..ellsairgskvpivvhcsagigrtgtivaieyi

LEQ-AKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAI
||. |.   .  .  .|. ||.||   .|.  ||.|.|  .|. .
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 962-1107 4.7e-34 112.5 In-house 87-233 (440) alignment 
Range on Protein: 962-1107
Range on HMM: 87-233/440.0
DSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATW-SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFL
.|.|| |||  .|||.||| .| |.. . ..|  .    ..||.|||||||.||||  ||.|  | .|||   .||  ..| .|..| .|||| .||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDAVLEAIICGETKIPTDKYQTKLQELKEIDSSTGCSGLQSQFDLLS
|.||||...||.| |  |    ......  .  |  | || .|.  |
heavlegllcgdtliledditerveqiqwpnphtdksplqqefegys
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1178-1277 4.8e-34 112.5 In-house 185-284 (290) alignment 
Range on Protein: 1178-1277
Range on HMM: 185-284/290.0
LTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.| |...| | .| |.|.||  ... | | | ...||||||||.||.|.|.. .....|| |||.||||| |  |  ||| |.| .||  |....  ||.
itnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 808-1073 1.4e-33 110.8 In-house 27-294 (310) alignment 
Range on Protein: 808-1073
Range on HMM: 27-294/310.0
NGFDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNldmCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIV
.|.  || .|        |     ..   ||. .. . |. |. || .        .|| | |.      . || ||||...|..||||.|.||.  ||.
eglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidks...ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MVTNLKEGTKSKCEQYWPNK--SEEFGPFTVMLISQQVyPDFVIRQLN---------VKIQDGSNDSHTLTQYHLTSWPDHGVPDYATplMSLHKQVMAT
.. .  |  . ||  |||    .| .|   |  .|.    .| | .|          |  |    .   ..  .   ||| ||||      .. ....| 
llckvgeegrpkcvgywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htvpqrllaq

WspSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLeAIICGET
    .|| .||||||..|... .|.........|   ||.  ..  |...|.. .||  ||....   . ..  |||
v..rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifarget
0040439 (Phosphotyrosine protein) phosphatases II 1119-1276 2.6e-33 111.1 In-house 6-246 (249) alignment 
Range on Protein: 1119-1276
Range on HMM: 6-246/249.0
NTAKAYPAKNRSSKFLPVELFLVPLQE-----ANGYINASFISGFHEKRAFIIAQSPMENTARD------------------------------------
   .. . |||.. .|| .   | |.       ..|||||.|.|.. ||.||..| |...|  |                                    
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

-----------------------------------------LTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQ
                                          |||| .||   . ..|. |. | . ....  ||||.||||. |.|.|...   . |||
leygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleq

CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 . |. ||.... | .|. .||||...|||  .|... ..|
lekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 1107-1277 1.7e-32 108.3 In-house 16-273 (278) alignment 
Range on Protein: 1107-1277
Range on HMM: 16-273/278.0
SQVTPDPDDVFTNTAKAYPAKNRSSKFLPVELFLVPlqeanGYINASFISGFheKRAFIIAQSPMENTARDL----------------------------
  ....|......      .||| . .||..   |      .|||||.|.|.  ...||..| |...|. |                             
llllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

-----------------------------------------------------TDWPQDGVVREP--RTVLQVIDDVIHRQQK------------IGGGP
                                                     . ||  ||  .|  . .|.... . .....             .|||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

VVVHCSDTVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVIDMYLQ
|.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..||||  .|... ..|.
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 862-1060 2.1e-32 107.1 In-house 74-273 (301) alignment 
Range on Protein: 862-1060
Range on HMM: 74-273/301.0
EREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSE---EFGPFTVMLISQQVYPDFVI--RQLNVKI
.|  | | .|.    ...|||.|||.|.|  ||| .. | .   |||...  | ...|||.| | | .   . | |.. . ....  .  |  |.|.|. 
krvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleved

QDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLhkqvMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQ
  |  ...|.| |  ..|.|.|||   . |. |    |     |. ||.||||||.||. .||. ..   . . .  ....  ...||..| . |||  |
stgkfatrtvthyqysewtdrgvPkshaelfdl....melvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq

YVFL
  ..
lywm
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1178-1277 2.2e-31 103.9 In-house 180-279 (287) alignment 
Range on Protein: 1178-1277
Range on HMM: 180-279/287.0
LTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.|.|.. | | ||.|.| ||.. .. |.| | ...|||||||| ||...|.. .....|| |||.||||| |  |  |||.| | |||. |.|.. .||.
itnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
0042113 (Phosphotyrosine protein) phosphatases II 1125-1276 4.6e-31 103.5 In-house 10-243 (245) alignment 
Range on Protein: 1125-1276
Range on HMM: 10-243/245.0
PAKNRSSKFLPVELFLVPLQEANG-----YINASFISGFHEKRAFIIAQSPMENTARD------------------------------------------
. |||.| .|| .  .| |.. .|     |||||...|.. .. ||..| |...|  |                                          
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdf

-----------------------------------LTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV
                                    ..|| .||   ....|.... | . ... ..|||.||||. |.|.|... . . ||| ..|. |
tvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgv

DVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
..... | .|. .||||.|..||  .|... ..|
sleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_egg_pd Subfamily egg 828-1084 1.1e-29 98.1 In-house 35-288 (307) alignment 
Range on Protein: 828-1084
Range on HMM: 35-288/307.0
GHRDENSGFNRFKNITVYDDNRIILkpNPNLDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtkSKCEQYWPNK
   |.|    | | .   |  |. |  . .  .   ..| | ...|    |.|| .| |.| |  ||||...||.   |||.|  ||    .|| |||. 
aasdnnlekarskrvhckdssrvkl..elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

SEE---F--GPF--TVMLISQQVYPDFVIRQLNVkiqDGSNDSHTLTQYHLTSWpdHGVPDYATPLMSLHKQVMAtwspsKGPILVHCSAGVGRTGTFIA
 ..   .  | .  . . . ..  | | . .|..    |..|     ..    .  . . |  .||  | |   .       |..|..  || ...|..|
esdslvtvpGslrienlkvdskadplfrvtklkl...vGgddeerflehwqgdv..nnssdvysplrvlrklrnl.....skpvvvqdilGvskaatlva

IDIALEQAKREGVV--DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVL---EAIIcGETKIPTDKYQTKL
|.||| .  |  ..   .   |  ||..|   |..  .|.|..  ||     .| | .|     |.  |
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi.gsakeldvdyerwl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 813-1067 2.2e-29 96.9 In-house 31-284 (302) alignment 
Range on Protein: 813-1067
Range on HMM: 31-284/302.0
QYENLSNP--HSKRCTIghRDENSGFNRFKNITVYDDNRIILKpnpnldMCEREYINASYIDGYSSSNKFIASQGPMKKTL---VDFWRLIWQEKPVSIV
.......   .  .|..    .|. .|. ... ..|.|...|.      ... .|.||| ..  . ... | .| | ...     .|||...||| ||.|
efkkidtmkvdlekCka..fkknlkknqsedvpildsnlvkle......aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv

MVTNLKEGTKsKCEQYWPNKSEEFGPFTVMLISQQVYPDFVIRQ--LNVKI-QDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPI
..   .| .|   ....|.||...  .  | . ..  .  .  .  . . .  .|  .|   . |.|| |... ||.  . |.   ..| |  .... ..
ilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadent

LVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEA
..    |.|| |.|..  .|.|. ...  . |. ||. .|.|| ..|..|.|||.|. |.|  
vivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 828-993 3.8e-29 96.5 In-house 28-193 (297) alignment 
Range on Protein: 828-993
Range on HMM: 28-193/297.0
GHRDENSGFNRFKNITVYDDNRIILKPNPnldmCEREYINASYIDG--YSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWP
 .|.     ||...|  .||.|. |.  .     ||.|||| |.      .  |.| .|||...|. |||.|....    ||||..|.|. ..||  |||
akrnsslrknryrdilatddtrvkllrvi....terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

NKSEE---FGPFTVMLISQQV--YPDFVIRQLNVKIQdgsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV
.  .|    | . |  .|.    .   .. .|..  .   ..|  ..     ||||||||     |  .. ||
svvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 836-1085 8.5e-28 91.9 In-house 46-293 (312) alignment 
Range on Protein: 836-1085
Range on HMM: 46-293/312.0
FNRFKNITVYDDNRIILKPNPNLdmcereYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNK-----SEE
.||. || ..|  |. |  . |.      || | ..   .  ..|...|||...| . ||.|      .||.... . | .  || .|  .       |.
lnrypniqcwdrgrftlagdenf......yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

FGPFT----VMLISQQVYPDFVIRQLNVKIQDGSNDSHtLTQYHLTSWPDHGVPDYATPLMSLhkqvMATWSPSKGPILVHCSAGVGRTGTFIAIDIALE
   .|     . |  .       | |.| ..   ..|. | .|  .||||||.||     . |    ...    | |.. |||||||||||.. |.  . 
hrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrl....lsavkkdkkpviahcsagvgrtgtlaliesmia

QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGETKIPTDKYQTKLQ
  .     ..  .   ||..| . |... |||.   .||| . .       ..  ||..
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1179-1278 9.4e-28 92.3 In-house 193-292 (298) alignment 
Range on Protein: 1179-1278
Range on HMM: 193-292/298.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
| ||. || .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  .|. 
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1179-1277 1.5e-27 91.4 In-house 145-243 (250) alignment 
Range on Protein: 1179-1277
Range on HMM: 145-243/250.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
. ||  || .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | | |||||.| |..|. .|.||..|||| ..| .|  .|.
vvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
0048076 (Phosphotyrosine protein) phosphatases II 954-1065 5.4e-27 89.6 In-house 36-140 (145) alignment 
Range on Protein: 954-1065
Range on HMM: 36-140/145.0
VkIQDGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSkGPILVHCSAGVGRTGTFIAIDIALEqakrEGvVDIAGIVNRLRQQRMKMVQT
.   . .. ... .||. ..|||||||| .  |... ... .  .   ||.|||||||||||||..|... |.    .| |..  .....|.||...|..
l.tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpn

LDQYVFLHDAVL
 .|. ||....|
pgqlrflyefel
subfamily_PTPRD_pd Subfamily PTPRD 1179-1278 5.9e-27 89.5 In-house 185-283 (564) alignment 
Range on Protein: 1179-1278
Range on HMM: 185-283/564.0
TDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
|.||. ||  .....|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | | |||  |...|  .|..
tsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 843-1070 6.4e-27 89.4 In-house 28-259 (290) alignment 
Range on Protein: 843-1070
Range on HMM: 28-259/290.0
TVYDDNRIILKPNPNldMCEREYINASYIDgYSSSNKFIASQGPMKKT-------LVDFWRLIWQEKPVSIVMVTNLKEGTKS----KCEQYWPNKSE--
..  ..|..||   .      .|| |...  ...  ..|..| | .|.       . .|| .. |||  ..||. . .| ..      |..| |.. .  
pLveatrvvLkgygk..rfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee

-EFGPFTVMLISQQVYPDFVIRQLNVKIQDGSndSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDIALEQA
  |. .||   |.    |. .|.| || .|.    .|.| . | .| .  |..    |.|| ..|.|    || |..|||  |. |  .. ||...    
lkfkgltvkCkskekeddvetRelvvkfddee..eftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdGiSrsAalaaiilgyQki

K-REGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLeaIIC
   .| | .. ... ||.|| .....  .. |   ...  .  
aetsgsvkledvlkalrkqralaitsalelafvdagiv..lla
0037934 (Phosphotyrosine protein) phosphatases II 1125-1275 1.4e-26 89.0 In-house 11-241 (243) alignment 
Range on Protein: 1125-1275
Range on HMM: 11-241/243.0
PAKNRSSKFLPVELFLVPLQEaNGYINASFISGFheKRaFIIAQSPMENTARD-----------------------------------------------
  ||| | .|| .   | |.  ..||||..| ..  .| .|. | |...|  |                                               
lsknrysdilpydhsrvkleg.sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvt

---------------------------------LTDWPQDGVVREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCk
                                  . ||  ||  .|  .|. .|.|.  ...        .||||.||||  |.|.|...   . |... 
llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.

aeGvVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVIDMY
  | ||.... | .|. .|| ||.|..||  .|... ..
..g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1179-1278 2.6e-26 87.4 In-house 186-285 (319) alignment 
Range on Protein: 1179-1278
Range on HMM: 186-285/319.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
|.||...| .. ...|... .. . ..|   ||.|||||. | | | .. ... ||. | |||.|||.. . .|  ..  | . |||. ||...  ....
teWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
0048179 (Phosphotyrosine protein) phosphatases II 964-1062 9.4e-26 85.7 In-house 47-139 (144) alignment 
Range on Protein: 964-1062
Range on HMM: 47-139/144.0
HTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSpSKGPILVHCSAGVGRTGTFIAIDIALeqakREGvVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
.. .||. ..||||||||... | .. . . .  . ..||.|||||||||||||..|... .    ..| ...  .....|..|. .|.. .|. ||..
regiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1178-1277 1.2e-25 85.3 In-house 182-281 (318) alignment 
Range on Protein: 1178-1277
Range on HMM: 182-281/318.0
LTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
 |.||. ||  .. ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | .||. ||||.  .|.
ytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 877-1061 2.1e-25 84.0 In-house 4-197 (199) alignment 
Range on Protein: 877-1061
Range on HMM: 4-197/199.0
SNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEEFGPFTVMLIS---QQVYPDFVIRQLNVKIQDGSND-SHTLTQYHLT
  ..||.| |...|. |||...|.     |||| . .   ..    |||      | .. . ..     . ||..|  | .  .  .   .  ...| .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDYAT--PLMSLHKQVMATWSPSK-GPILVHCSAGVGRTGTFIAIDIALEQ--AKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
|| ..  |. |    ..   ..|   .   |  |..|||| | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 878-1061 2.5e-25 83.8 In-house 4-196 (198) alignment 
Range on Protein: 878-1061
Range on HMM: 4-196/198.0
NKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEEFGPFTVMLIS---QQVYPDFVIRQLNVKIQDGSND-SHTLTQYHLTS
 ..||.| |...|| |||...|.     |||| . .   ..    |||      | .. . ..     . ||..|  | .  .  .   .  ...| .||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDYAT--PLMSLHKQVMATWSPSK-GPILVHCSAGVGRTGTFIAIDIALEQ--AKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
| ..  |. |    ..   ..|   .   |  |..|||| | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
Y_phosphatase Protein-tyrosine phosphatase 1178-1272 3.7e-23 77.5 Pfam-A 140-233 (235) alignment 
Range on Protein: 1178-1272
Range on HMM: 140-233/235.0
LTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
ytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1178-1272 3.7e-23 77.5 In-house 140-233 (235) alignment 
Range on Protein: 1178-1272
Range on HMM: 140-233/235.0
LTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
ytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_CG42327_pd Subfamily CG42327 861-996 4e-23 76.6 In-house 54-193 (319) alignment 
Range on Protein: 861-996
Range on HMM: 54-193/319.0
CEREYINASYIDGYSS-SNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKS-----EEFGPFTVMLISQQVYPDFVIRQLNV
 . ||..|||. || .  | .||.| .....  ||||..|. .   || .|.| |    .| .|.| |      . .| . | |  ..|   ..|  | .
dkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll

KIQDGSnDSHTLTQYHLtSWPDHGVPDYATPLMSLHKQVMAT
|  |..  |  || |    |.. .||   ..|...  .| ..
krvdke.esrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 872-1067 6.7e-23 75.6 In-house 84-287 (302) alignment 
Range on Protein: 872-1067
Range on HMM: 84-287/302.0
DGYSSSNKFI-ASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSE---EFGPFTVMLISQQV-YPD------FVIRQLNVK---IQ
||    .|       | |.||  .| || | .   .| .....|. . || .|. .| .   .|| .||  .| .    .      |.. ....|    .
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

DgsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtWspsKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQY
.  .  .|.   . ..||||| |. | . . . |   . .   |  .|||||||||||||..||   ..  ... | |.. ||  .|| |   ||. .| 
k..kvkktvdilafsawpdhGapkeaytaldilkfces.y...kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql

VFLHDAVLEA
..|   |  .
iylllcvtkg
DSPc_SM00195 1179-1276 6.7e-23 76.7 In-house 166-262 (263) alignment 
Range on Protein: 1179-1276
Range on HMM: 166-262/263.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
..||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
knWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1179-1276 6.7e-23 76.7 In-house 166-262 (263) alignment 
Range on Protein: 1179-1276
Range on HMM: 166-262/263.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
..||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
knWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRA_pd Subfamily PTPRA 1178-1275 7.7e-23 75.9 In-house 198-294 (330) alignment 
Range on Protein: 1178-1275
Range on HMM: 198-294/330.0
LTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
.| ||. ||  ||. .|...  | . .|. .| |.|||||  | |.| .. ..  ||. |||..||||.. | .|  .|  | |.|||. || |.  |
ftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1083-1177 4e-22 73.5 In-house 6-101 (287) alignment 
Range on Protein: 1083-1177
Range on HMM: 6-101/287.0
KLQELKEIDSSTGCSGLQSQFDLLSQVTPDPDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQ-EANGYINASFISGFHEKRAFIIAQSPMENTARD
|. |. . .  .|  | . || .| ||| ..|.|  | |.    |||....|. . . |.|. | . ||||.|| |..||.|||||.||| ||||.
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarn
PTPc_DSPc_SM00012 1179-1272 5.1e-22 73.4 In-house 8-103 (105) alignment 
Range on Protein: 1179-1272
Range on HMM: 8-103/105.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|.||. || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...| . ||.||. |..|...||.|.|.|||  .|...
tgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
subfamily_PTPRK_pd Subfamily PTPRK 1179-1272 1.6e-21 71.5 In-house 181-273 (314) alignment 
Range on Protein: 1179-1272
Range on HMM: 181-273/314.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. ||. .|  . ...|...  | . |.. . |..|||||    |.|... ..| |.  . |||||||.. |..| .|.  | | |||. |||||
lgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_CG7180_pd Subfamily CG7180 1191-1276 5.7e-21 69.4 In-house 201-290 (296) alignment 
Range on Protein: 1191-1276
Range on HMM: 201-290/296.0
RTVLQVIDDVIHRQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 ......  |   ..|.      |||||..|| .||||||... . ||. . |. ||||.  | .|||.|. | . |.|  ||||.  ..
nalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 836-940 6e-20 66.2 In-house 50-164 (350) alignment 
Range on Protein: 836-940
Range on HMM: 50-164/350.0
FNRFKNITVYDDNRIILK--PN----PNLDMCEREYINASYIDGY------SSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQY
 ||.|||  |. .|..||  ..     .  .   .||||.|.          .. |.|| |.|...|. ||...| . |   |...|.. |    ||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPNKSEEfgPFTVMLIS
|.. | .   .|| | |
Wqegsyd..ditvklas
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1179-1277 1.1e-19 65.6 In-house 169-269 (274) alignment 
Range on Protein: 1179-1277
Range on HMM: 169-269/274.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
||||   . ....|.|.....| . ...     .|||||||  . | |.. ..||.. | ..|.||||....  .|  . | | | |||  |. .. .||
tdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl

Q
.
k
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1177-1277 3.9e-19 63.1 In-house 178-277 (515) alignment 
Range on Protein: 1177-1277
Range on HMM: 178-277/515.0
DLTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
..|.||. || .. ...|..| .|   ....   |...|||  | | ||..|.   . . |   .||||.. . .|. .|  | | |||. ||...  .|
hfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

Q
 
l
subfamily_PTPN6_pd Subfamily PTPN6 1179-1279 4.1e-19 63.7 In-house 194-300 (306) alignment 
Range on Protein: 1179-1279
Range on HMM: 194-300/306.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
..||. || ..| .||. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | | .||  .| .|
ksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai

DMYLQMN
 .|.. .
kkyietk
0041856 (Phosphotyrosine protein) phosphatases II 1127-1277 6.3e-19 63.7 In-house 4-172 (182) alignment 
Range on Protein: 1127-1277
Range on HMM: 4-172/182.0
KNRSSKFLPVELFLvplqeANGYINASFISGFHEKRAFIIAQSPMENTARDL----------------------------------TDWPQDGVVRePRT
||| |..||..  .      . ||||... | .  . ||..| |. .|  |                                   . || .||   ...
knrysdilpydhsr.....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd.lde

VLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.|. |..|..      ||||.||||  |.|.|...   . ...    | |..... | ||. .||.|.|..||  ..... ..|.
lldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 890-1087 6.5e-19 63.0 In-house 40-234 (255) alignment 
Range on Protein: 890-1087
Range on HMM: 40-234/255.0
TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEEFGPFT-VMLISQQVYPDFVIRQLNVKIQDG-SNDSHTLTQYHLTSWPDHGVPDYATPLM
|.  |.. | | |.  .||.....| .. ||..|.| . .|   .. | ... .   | |.| |..  . |     ||.. |. . |...  |. |  ..
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

SLHKQVMAtwspSkGPILVHCSAGVGRTGTFIAIDIALE------QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIicgetkIPTDKYQ
 . | |      |  ...||||.|.||. .|. ....        .    . .|   ... ||..| . ..|  |  |    ||. .       | ....
nilkvvrd....s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv......fpkgele

TKLQEL
 |.||.
akyqei
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1178-1272 8.5e-19 62.6 In-house 182-275 (315) alignment 
Range on Protein: 1178-1272
Range on HMM: 182-275/315.0
LTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.| ||. || .   .....|  |   ...   |..|||||. | |.| .....  |.| .|| ..||... . ||. . ..| ..|||  |||..
ytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1177-1277 1.3e-18 61.9 In-house 179-278 (315) alignment 
Range on Protein: 1177-1277
Range on HMM: 179-278/315.0
DLTDWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
..|.||. || ..  ..|..| .|    ..    ...||||  | |.|| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||..  .|
qftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

Q
.
l
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1178-1278 1.5e-18 61.9 In-house 184-286 (297) alignment 
Range on Protein: 1178-1278
Range on HMM: 184-286/297.0
LTDWPQDGVVR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
 ..||.. | |  . ...|..|..| .  ..   ||..|||.  | | ||....   . . | |  ||.|.. | .|...|  | | |||. .| ..  .
fveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea

LQM
|  
lls
subfamily_PTPRG_pd Subfamily PTPRG 1178-1273 2.1e-18 60.9 In-house 190-284 (563) alignment 
Range on Protein: 1178-1273
Range on HMM: 190-284/563.0
LTDWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
 |.||. ||   .  ||. .     . .|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |||. ..|.. 
ytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 993-1068 2.6e-18 60.9 In-house 220-295 (297) alignment 
Range on Protein: 993-1068
Range on HMM: 220-295/297.0
VMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAI
 . .  | . ..||||||||||.|  .  |. |.. ... . |.| |.. ||.|| ..||||.|. .|.||||. .
slraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Ptp69D_pd Subfamily Ptp69D 1179-1273 2.6e-18 61.2 In-house 190-283 (307) alignment 
Range on Protein: 1179-1273
Range on HMM: 190-283/307.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
| |.   | . .|..|..|. | . ...   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  . 
tgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyrall
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1197-1272 4.7e-18 60.1 In-house 187-262 (283) alignment 
Range on Protein: 1197-1272
Range on HMM: 187-262/283.0
IDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.. ||  |..   ||.||||| .. |..|....|  ... ..| |||||.| | .|  ...|| ||.||  .....
fnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0051429 (Phosphotyrosine protein) phosphatases II 1147-1276 1.2e-17 59.9 In-house 4-225 (272) alignment 
Range on Protein: 1147-1276
Range on HMM: 4-225/272.0
NGYINASFISGFHE---KRAFIIAQSPMENTARDL-----------------------------------------------------------------
.|||||....|..    ..... .. |...||.|.                                                                 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

------------------------TDWPQDGVVREPrtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD--------VFQ
                        |||| .|| .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||        ...
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

VTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
. . .|.  |||| | |||  .|...  .|
aveelraqrpgavqteeqylflyeallell
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1001-1065 2.2e-17 57.8 In-house 262-341 (350) alignment 
Range on Protein: 1001-1065
Range on HMM: 262-341/350.0
KGPILVHCSAGVGRTGTFIAIDIALE------Q-AKRE-------GVV-DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVL
  |||||||||||||||....|  |.      .  |.         .   |  |||.||.||..|||.|||..|...|.|
sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1145-1272 2.3e-17 57.5 In-house 73-190 (440) alignment 
Range on Protein: 1145-1272
Range on HMM: 73-190/440.0
EANGYINASFISGFHEkRAfiIAQspmentaRDLTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDV
  . |||||.|.| .  |.  . |            ||. || .    ||..|.|| . |.| | ||..||||  ..|.||  .|   | ..|    .|.
pdsdyinasyingies.rt..lkq.......yhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidi

FQVTKAVRRSKPGAVTTLEQYTSIYDVI
| . ...| ..|  | | |||. .....
fsfinsmrnnrpqmvqtpeqyafvheav
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1005-1071 3.3e-17 56.6 In-house 2-68 (69) alignment 
Range on Protein: 1005-1071
Range on HMM: 2-68/69.0
LVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICG
.||||.| ||||||||| . . . | | .|||   |. .|. |  ||    .|.|.|||. ||.  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
0036282 (Phosphotyrosine protein) phosphatases II 1147-1270 3.4e-17 58.1 In-house 2-164 (174) alignment 
Range on Protein: 1147-1270
Range on HMM: 2-164/174.0
NGYINASFISGFHEKRAFIIAQSPMEnTARD------------------------------------------LTDWPQDGVVREPRtVLQVIDDVIHRQ
. |||||......  . .|. | |..   .                                            . || .||   .  .|.... | . .
sdyinaspldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveeal

QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
.. .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1006-1071 5.3e-17 55.9 In-house 2-67 (69) alignment 
Range on Protein: 1006-1071
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICG
||||.| ||||||||| . . . | | .|||   |. .|. |  ||   ..|.|.|||. ||.  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_CG42327_pd Subfamily CG42327 1000-1062 8.5e-17 55.8 In-house 246-309 (319) alignment 
Range on Protein: 1000-1062
Range on HMM: 246-309/319.0
SKGPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
|.||. |||| ||||||. || |||... .     |||  .|  .|..| . |.| .|| |.. 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk
0049772 (Phosphotyrosine protein) phosphatases II 1112-1278 9.3e-17 57.2 In-house 34-282 (314) alignment 
Range on Protein: 1112-1278
Range on HMM: 34-282/314.0
DPDDVFTNTAKAYPAKNRSSKFLPVElFLVPLQ----EANGYINASFISGFhekRAFIIAQSPMENTARDL-----------------------------
 .  . .    . . |||. ..||..  .| |.    .  .|||||...||   ..||..| |.|.|  |.                             
peltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

--------------------------------------------T------------DWPQdGVVREPRTVLQVIdDVIHRQqkIGGGPVVVHCSDTVSR
                                                         ..|  | .  .. ..... ..|..     ||||.|||.. ..|
evladelsrLdaAlgKtpllildgngneptaadlellkeelydpelferlgikylripvpD.gsaplledfdefl.efieea..dkggpvlvHCkaGkgR

SGVYCSVSIGLEQCkaeGVvDVFQVTKAVRRSKP-----GAVTTLEQYTSIYDVIDMYLQM
.|... . . . ..   || .. .. . ||.  |     |.. .||||  |.... .||..
tgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1179-1278 2.9e-16 54.3 In-house 160-266 (270) alignment 
Range on Protein: 1179-1278
Range on HMM: 160-266/270.0
TDWPQDGVVREPR------TVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
..||..||.||.        .|... .|  .....  ..|..||||. | |.|.   . |...  . .. ||| .. ...|. ..  | . |||. .| .
ntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflyka

IDMYLQM
. .| ..
vveyaer
0043147 (Phosphotyrosine protein) phosphatases II 1146-1270 3.3e-16 55.0 In-house 4-155 (172) alignment 
Range on Protein: 1146-1270
Range on HMM: 4-155/172.0
ANGYINASFISGFHEKRAFIIAQSPMENTARDLT----------------------------------DWPQDGVVrEPRTVLQVIDDVIHRQQKIGGGP
 . |||||.... .  . ||. | |. ||  |                                     ||  ||   .. .|.... . .....  |||
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggp

VVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|.||||  |.|.|. .   . |        . ..... . ||. .||||.. .||  .|.
vlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1178-1274 8.3e-16 53.0 In-house 185-286 (325) alignment 
Range on Protein: 1178-1274
Range on HMM: 185-286/325.0
LTDWPQDGVVREPRTVLQVIDDVIHRQQKI-----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|  |.. || . | |.. ... | . ....     . .|..||||. | |.||. |.   |..   |  ||.|.. | .|. .|  | | .||. ||. .
lqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal

DM
  
ve
subfamily_PTPN12_pd Subfamily PTPN12 1179-1277 9.1e-16 52.6 In-house 178-278 (290) alignment 
Range on Protein: 1179-1277
Range on HMM: 178-278/290.0
TDWPQDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
|.||  || . . ..|..|..| ..|.     |.|||||  | | |. ... .  |. ||| .   .|||..   .|. .. .| | |||. .|  .  .
taWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

LQ
.|
vq
subfamily_PTPRB_pd Subfamily PTPRB 1179-1277 2.5e-15 51.3 In-house 187-286 (293) alignment 
Range on Protein: 1179-1277
Range on HMM: 187-286/293.0
TDWPQDGVVREPRTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
| ||. ||  ...|.|. .  | ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .|.
tsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1179-1272 5.3e-15 50.2 In-house 183-275 (288) alignment 
Range on Protein: 1179-1272
Range on HMM: 183-275/288.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. ||..|| .  . .|.... |   .|.   ||..||||. | |.|.. ..   ... ..| ..||. . . .|....  | ||.||  ||.|.
laWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1180-1271 6.3e-15 50.3 In-house 194-286 (319) alignment 
Range on Protein: 1180-1271
Range on HMM: 194-286/319.0
DWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
GwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1179-1271 8.2e-15 50.0 In-house 157-250 (284) alignment 
Range on Protein: 1179-1271
Range on HMM: 157-250/284.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
  ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
lgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_hpo-7_pd Subfamily hpo-7 888-1087 1.3e-14 48.7 In-house 44-243 (263) alignment 
Range on Protein: 888-1087
Range on HMM: 44-243/263.0
KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNKSEEFGPFT-VMLISQQVYPDFVIRQLNVKIQDG-SNDSHTLTQYHLTSWPDHGVPDYATP
 .|.  |.. | | |.  .||... .|  . ||..|.| . .|   .. | . . .|  | ... |..  . |     ||...|  . |...  |  |  
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

LMSLHKQVmatwSPSKgPILVHCSAGVGRTGTFIAIDIALE------QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIIcgeTKIPTDK
 . . | .      || .. ||||.|.||.  |  ....        .    . .|   ... ||..| . ..|  |  |    ||. ..      . . 
ilnilkva....rnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl...nnfakge

YQTKLQEL
 ..| ||.
leakyqei
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 832-1070 1.4e-14 48.5 In-house 46-281 (303) alignment 
Range on Protein: 832-1070
Range on HMM: 46-281/303.0
ENSGFNRFKNITVYDDNRIilkpnpnlDMCEREYINASYIDgYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNkSEEF
.|   ||| .. . |  ..         ...  || |||..   ||.| | .| |. .|  |||..| ..|   ....    |  |   .  .|.  ..|
knmdknrfvdvicldhskv........klsdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr.nqdf

GPFTVMLISQQVYPDFVI-RQLNVKIQDGSNDSH--TLTQYHLTSWPDHGVPDYATPLMSL----HKQVMATWSPSKGPILVHCSaGVGRTGTFIAIDIA
  |    |    .    .    ..|.   || ..   |  .|  .||   .|  ..| .       . |.  .|.|. .. .  | |.||.|||  .. |
lkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls.gcgragtfalfeta

LE-QAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIIC
     . .  .|.   .. .|. |.. || | |. ...  . | .. 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1202-1273 4.4e-14 47.1 In-house 185-256 (267) alignment 
Range on Protein: 1202-1273
Range on HMM: 185-256/267.0
HRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
. | . |. |.||.||| | ||| .  .   ||. | |||.|.|.  . .|  ..| | |.|.|  |.... 
knqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella
subfamily_PTPN13_pd Subfamily PTPN13 1178-1277 4.9e-14 47.3 In-house 173-270 (273) alignment 
Range on Protein: 1178-1277
Range on HMM: 173-270/273.0
LTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
...||  || ...  .||..  | . |.    ||.|||||  . |||.. .. . |.  . .  .|| .. . .|. . | | | .||  .| .|   |.
fvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
0046846 (Phosphotyrosine protein) phosphatases II 1146-1276 5.9e-14 47.7 In-house 11-173 (176) alignment 
Range on Protein: 1146-1276
Range on HMM: 11-173/176.0
ANGYINASFISGFHekraFIIAQSPMENTARD---------------------------LTDWPQ--------------DGVVREPRTVLQVIDDVIHRQ
   ||||..| | .    .|. | |...|  |                            ..||.              |. | . . .|.... .  ..
dldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefireal

QKigGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRRSKP-GAVTTLEQYTSIYDVIDMYL
..  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| |||  .|... ..|
ke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1178-1272 2.2e-13 45.0 In-house 140-235 (237) alignment 
Range on Protein: 1178-1272
Range on HMM: 140-235/237.0
LTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.| ||. || ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  ...   .|  . | .||  |...|
ftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1177-1272 2.3e-13 44.3 In-house 138-232 (392) alignment 
Range on Protein: 1177-1272
Range on HMM: 138-232/392.0
DLTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 .|.||...| .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | |||. ||  .
hftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1179-1277 2.3e-13 44.9 In-house 178-277 (281) alignment 
Range on Protein: 1179-1277
Range on HMM: 178-277/281.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
| ||. ||  ... .|.  ..| . ..|    |.|.|||  | |.|.| ..   .....||   .|| .| . .|...   | |. ||. .| ..  .|.
taWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1094-1177 3.1e-13 44.6 In-house 19-104 (305) alignment 
Range on Protein: 1094-1177
Range on HMM: 19-104/305.0
TGCSGLQSQFDLLSQVtPDPDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQEANG---YINASFISGFHEKRAFIIAQSPMENTARD
. ..||. |...| .  ... || ...|..   ....   |. . . .  .| ..   |||||.. |...| ..|.||.|..|| .|
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvad
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 872-955 4.3e-13 43.4 In-house 230-312 (440) alignment 
Range on Protein: 872-955
Range on HMM: 230-312/440.0
DGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTkskCEQYWPN--KSEEFGPFTVMLISQQVYPDFVIRQLNVK
.|||  | |||.| |.  |..|||||. . .  .|.|. .|.. |   |  |||   .|  ||||||     .      .| |..|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1177-1269 4.8e-13 43.8 In-house 143-234 (239) alignment 
Range on Protein: 1177-1269
Range on HMM: 143-234/239.0
DLTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
 .| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
hftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1177-1269 4.8e-13 43.8 In-house 142-233 (239) alignment 
Range on Protein: 1177-1269
Range on HMM: 142-233/239.0
DLTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
 .| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
hftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1071-1177 6.4e-13 43.6 In-house 1-114 (298) alignment 
Range on Protein: 1071-1177
Range on HMM: 1-114/298.0
GETKIPTDKYQTKLQELKEIDSSTGCSGLQSQFDLLSQVTPDPDDVFTNTA--KAYPAKNRSSKFLPVELFLVPLQE-----ANGYINASFISGFHEKRA
|.|.| .......||.|.... ... .|....|  |..|. . ..  .. |  ..   ||| .. ....   | |..        ||||||....... |
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAQSPMENTARD
||..| |...|  |
fiatqaPltetved
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1002-1066 1.2e-12 41.8 In-house 266-342 (349) alignment 
Range on Protein: 1002-1066
Range on HMM: 266-342/349.0
GPILVHCSAGVGRTGTFIAIDIALE---QAKREGV--------V-DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
 ..||||||| ||||... .|. |.     ..| .           |  ||| ||.||. ||| | |......|.|.
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1089-1177 1.8e-12 41.7 In-house 12-106 (290) alignment 
Range on Protein: 1089-1177
Range on HMM: 12-106/290.0
EIDSSTGCSGLQSQFDLLSQvTPDPDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQ---E----ANGYINASFISGFHEKRAFIIAQSPMENTARD
. . ..| .| ..||  | . .  .  | .....    .||...... . . ..|.   .    .| ||||..| |..||...|..|.|..||..|
anghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvd
subfamily_PTPN23_pd Subfamily PTPN23 1178-1272 2.5e-12 41.2 In-house 178-276 (288) alignment 
Range on Protein: 1178-1272
Range on HMM: 178-276/288.0
LTDWPQDGVVREPRTVLQVIDDVIH---RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|| ||. ||   | |.||..| | .    .|.    |.|||||  | |.||.. |   ...  | .|..|. || . .|. .   | . ||.   |...
ltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
0049260 (Phosphotyrosine protein) phosphatases II 1155-1270 3.2e-12 41.9 In-house 2-144 (152) alignment 
Range on Protein: 1155-1270
Range on HMM: 2-144/152.0
ISGFHEKRAFIIAQSPMENTARDLTD---------------------------------WPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVS
|.|.. ...||..| |..||. |  .                                 .  |. | .   .|. . ..|.. ..  ||||.||||  |.
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvg

RSGVYCSVSIGLeqckaeGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|.|...   . |        |..... . ||. .||||.. .|.  .|.
Rtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_CG42327_pd Subfamily CG42327 1208-1276 4.4e-12 40.3 In-house 246-315 (319) alignment 
Range on Protein: 1208-1276
Range on HMM: 246-315/319.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  ||.|||||| | |.|.  .  | ... .     ||. |.   ||| .  || | |||  || |. .| 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_PTPN14_pd Subfamily PTPN14 1179-1277 5.9e-12 40.2 In-house 191-297 (300) alignment 
Range on Protein: 1179-1277
Range on HMM: 191-297/300.0
TDWPQDGVVREPRTVLQVIDDV---IH-RQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
||||..|| ..... |. ...|    .  ....       ||.||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.
tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYk

VIDMYLQ
|.  ||.
vlikylk
subfamily_PTPN9_pd Subfamily PTPN9 1203-1272 8.2e-12 39.7 In-house 217-286 (297) alignment 
Range on Protein: 1203-1272
Range on HMM: 217-286/297.0
RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 . .. | |.|||||  . |.| .... | |.. . .|.|||... | .|  .  .. | |||.  |  .
wkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
DSPc_SM00195 1099-1177 1.2e-11 39.9 In-house 2-84 (263) alignment 
Range on Protein: 1099-1177
Range on HMM: 2-84/263.0
LQSQFDLLSQVTPDPdDVFTNTAKAYPAKNRSSKFLPVELFLVPLQEA-----NGYINASFISGFHEKRAFIIAQSPMENTARD
|. .|. | . |..  .. ..  |.  .|||....||..   | |..      . ||||..|.| ..|...|..| |...| .|
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstved
PTPc_SM00194 1099-1177 1.2e-11 39.9 In-house 2-84 (263) alignment 
Range on Protein: 1099-1177
Range on HMM: 2-84/263.0
LQSQFDLLSQVTPDPdDVFTNTAKAYPAKNRSSKFLPVELFLVPLQEA-----NGYINASFISGFHEKRAFIIAQSPMENTARD
|. .|. | . |..  .. ..  |.  .|||....||..   | |..      . ||||..|.| ..|...|..| |...| .|
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstved
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 792-885 1.4e-11 38.4 In-house 4-95 (95) alignment 
Range on Protein: 792-885
Range on HMM: 4-95/95.0
PVSVDELGTHVATCHSNG---FDEQYENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNpnldmCEREYINASYIDGYSSSNKFIASQG
|. |  . .||   |||    ||...  .|       |.|  . |   ||| ||  ||  |..|  .      . .|||| ..|||.  | .||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttk.....rdsdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1179-1272 1.7e-11 38.2 In-house 182-275 (439) alignment 
Range on Protein: 1179-1272
Range on HMM: 182-275/439.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. ||.  |  .   ||. .  .   ..|   ||||||||  | |.|   .. | ||| |.|  ||.  . | .|. .   | .| ||  ||. .
iawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
0051082 (Phosphotyrosine protein) phosphatases II 1147-1271 1.9e-11 39.3 In-house 3-148 (151) alignment 
Range on Protein: 1147-1271
Range on HMM: 3-148/151.0
NGYINASFISGFhekraFIIAQSPMENTARD------------------------------------LTDWPQDGVVREPRTVLQVIDDVIHrqqkIGGG
..|||.|.. |.     ... . |..   .                                     ..|||  |.   . .||.... ...     ..|
sdyinfsyvtgg.....lyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld....kkng

PVVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
pvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
0048076 (Phosphotyrosine protein) phosphatases II 1179-1275 2e-11 39.2 In-house 53-142 (145) alignment 
Range on Protein: 1179-1275
Range on HMM: 53-142/145.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiGLEQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
..||  ||   ....|.... . . ...  ||||.||||  |.|.|...    ..  .. .| |..... . ||.  ||||.. .|.  .|... ..
lpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 815-910 2.3e-11 37.8 In-house 19-117 (347) alignment 
Range on Protein: 815-910
Range on HMM: 19-117/347.0
ENLSNPHSKRCTIGHRDENSGFNRFKNITVYDDNRIILKPNPNlDMC----EREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVT
|||.|    ..|    . .   || |.  . |. |..| |.   ...       |||||.|    .|...| .| |. .|. |||...   |   .| . 
enlanyspskftsvewekslsknrskdvklidatrvvlspeks.knsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1093-1178 2.4e-11 37.9 In-house 11-101 (301) alignment 
Range on Protein: 1093-1178
Range on HMM: 11-101/301.0
STGCSGLQSQFDLLSQVTPDPDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQEA-----NGYINASFISGFHEKRAFIIAQSPMENTARDL
..   ....|.. |....... .| .. .... ..... . .. . ...  ...     . |||||.|.|. ||..||.||.||..| .|.
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdf
subfamily_PTPN3_pd Subfamily PTPN3 1179-1272 2.6e-11 38.0 In-house 179-271 (280) alignment 
Range on Protein: 1179-1272
Range on HMM: 179-271/280.0
TDWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
..||. ||  ..  .|.... | .....    |||||||  . |.||.  . . |    |.  | . .. . .|  .   | | .||. . . |
laWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 836-928 3.8e-11 36.9 In-house 51-157 (349) alignment 
Range on Protein: 836-928
Range on HMM: 51-157/349.0
FNRFKNITVYDDNRIILKPNPNL-----------DMCE-REYINASYID--GYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCE
 ||.|.|  |.  |..||  ..            | .   .|||| |.    .|  .|.|| | |.  |. ||...|  ..   .. ... || .  ||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWPNKS
.|| . |
iywqels
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1099-1185 4.3e-11 37.3 In-house 8-96 (267) alignment 
Range on Protein: 1099-1185
Range on HMM: 8-96/267.0
LQSQFDLLSQVTPDPDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQE-ANGYINASFISGFHEKRAFIIAQSPMENTARD-LTDWPQDG
.. .|.|. .....   . .  |.   ..||  . || .   |.|..  . |||||.. |.. |.|||. | |..||  | || ... .
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqk
0044763 (Phosphotyrosine protein) phosphatases II 1135-1278 6.3e-11 37.7 In-house 6-173 (178) alignment 
Range on Protein: 1135-1278
Range on HMM: 6-173/178.0
PVELFLVPLQEANGYINASFISGFhekraFIIAQSPMENTAR----------------------------------DLTDWPQD-GVVREPRTVLQVIDD
.| |. ..  |.  |||||.| ..     ..... |...  .                                      .| . . | . .  .. . .
rvllsnleglersdyinaseilpg.....lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefve

VIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRRSKPgAVTTLEQYTSIYDVIDMYLQM
 |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .|.  .|..  ..|..
fieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrllke
subfamily_Ptp69D_pd Subfamily Ptp69D 1124-1177 6.9e-11 36.8 In-house 48-106 (307) alignment 
Range on Protein: 1124-1177
Range on HMM: 48-106/307.0
YPAKNRSSKFLP-----VELFLVPLQEANGYINASFISGFHEKRAFIIAQSPMENTARD
   |||. .  .     | |  .. .|   ||||||| |..||. ||.|| |.|.|. |
nalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigD
subfamily_PTPRG_pd Subfamily PTPRG 1095-1177 1.2e-10 35.2 In-house 17-106 (563) alignment 
Range on Protein: 1095-1177
Range on HMM: 17-106/563.0
GCSGLQSQFD-LLSQVTPDPDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQEANG------YINASFISGFHEKRAFIIAQSPMENTARD
|  |.. .|. | |.....  |. .  ..    ||| .. ....   | |..  |      ||||..| |.. ..|||..| |...|. |
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfdd
subfamily_eak_pd Subfamily eak 826-991 1.4e-10 35.0 In-house 45-205 (332) alignment 
Range on Protein: 826-991
Range on HMM: 45-205/332.0
TIGHRDENSGFNrFKNITVYDDNRIILKPNpnlDMCEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWP
. . | |.   |   .|  || . . | .     . .  ||||| ..     .|.| .  . .. .  ||... ..|  .||.. .  |    | ..|.|
setarleavnrn.vvkivpydrylvrltss...qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp

NKSEEFGPFTVMLISQQVYP---DFVIRQLnvKIQDGsNDSHTLTQYHLTSWPDHGVPDYATpLMSLHK
.|. |   | .. . .. .     .  |.|  ... | |..| .  |..  | .  .| |   ...|.|
dktreelkfGildverkefvkrniletrll..elskG.nethrvlhykvfGwtettlpkyed.flalrk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 829-979 1.7e-10 34.9 In-house 92-235 (244) alignment 
Range on Protein: 829-979
Range on HMM: 92-235/244.0
HRDENSGFNRFKNITVYDDNRIILKPNpnlDMcEREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWqEKPVSIVMVTnlkeGTKSKCEQYWPNkS
   .||  ||      .| ||. |       |    |||||..     . ..| .| |.  | .|||...  |. | ...|     |.  . ..|||. |
fnpnnswknregaglpfdfnrvplskg...sm.gntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvl....gsveeedeywpd.s

EEF----GPFTVMLISQQVYPDfvIRQLNVKIQDGSNDSH-TLTQYHLTSWPDHGV
| .       || |  .. . .  |.  |..|.   |.|| .|| . .. ||  | 
eplewyeeditvtltdrdefkn..ikasnleiesdmneshqaltmfqisnwpsdgt
Y_phosphatase Protein-tyrosine phosphatase 1126-1177 1.8e-10 36.0 Pfam-A 3-57 (235) alignment 
Range on Protein: 1126-1177
Range on HMM: 3-57/235.0
AKNRSSKFLPVELFLVPL---QEANGYINASFISGFHEKRAFIIAQSPMENTARD
 |||....|| .   | |   .... ||||....|..||..||..| |...|  |
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstied
Y_phosphatase Protein-tyrosine phosphatase 1126-1177 1.8e-10 36.0 In-house 3-57 (235) alignment 
Range on Protein: 1126-1177
Range on HMM: 3-57/235.0
AKNRSSKFLPVELFLVPL---QEANGYINASFISGFHEKRAFIIAQSPMENTARD
 |||....|| .   | |   .... ||||....|..||..||..| |...|  |
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstied
fn3 Fibronectin type III domain 218-292 2e-10 33.9 Pfam-A 2-79 (85) alignment 
Range on Protein: 218-292
Range on HMM: 2-79/85.0
APSSLTEVSKTATTITVNWTALE--SFDANGYVVNVTSDTDT--VQTVQVEGSSNnTITLNGLRELTTYSITVRAYQQL
||. |.  . |.|..|..|.. .  . .  || | . .....   ....|..... . ||.||.. |.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
0048179 (Phosphotyrosine protein) phosphatases II 1179-1270 2.4e-10 35.8 In-house 55-139 (144) alignment 
Range on Protein: 1179-1270
Range on HMM: 55-139/144.0
TDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
..||  ||   .  .|.... . . ..   ||||.||||  |.|.|...        .| .| ...... . ||.  ||||.. .|.  ...
lpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1209-1271 5.6e-10 33.7 In-house 134-198 (198) alignment 
Range on Protein: 1209-1271
Range on HMM: 134-198/198.0
GGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
  ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1209-1271 5.7e-10 33.7 In-house 135-199 (199) alignment 
Range on Protein: 1209-1271
Range on HMM: 135-199/199.0
GGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
  ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1179-1268 7.8e-10 32.7 In-house 196-280 (302) alignment 
Range on Protein: 1179-1268
Range on HMM: 196-280/302.0
TDWPQDGVVREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
. ||. |  .|. | |...      ...     |.||||  | |.|   ..  |.. |. . | |. .. . ||. . ||| . .| . .
sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_PTPRB_pd Subfamily PTPRB 1079-1178 8.2e-10 33.2 In-house 11-110 (293) alignment 
Range on Protein: 1079-1178
Range on HMM: 11-110/293.0
KYQTKLQELKEiDSSTgcsGLQSQFDLLSQVTPDPDDVFtNTAKAYPAKNRSSKFLPVELFLVPL-----QEANGYINASFISGFHEKRAFIIAQSPMEN
|... ....|. || .   ... ... |..|  |   .. .....  |||| .. || .   | |     .. . ||||..|.|.. .| || .| |. .
kfeehvkkmka.dsdl...rfseeyeelkavgkdqavka.aelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TARDL
|  |.
tvddf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1110-1177 1.8e-09 32.1 In-house 34-106 (319) alignment 
Range on Protein: 1110-1177
Range on HMM: 34-106/319.0
TPDPDDVFTNTAKAYPAKNRSSKFLP-----VELFLVPLQEANGYINASFISGFHEKRAFIIAQSPMENTARD
....|.. . . .    ||| .  |.     | |  .. .|   ||||||| |..|...|| .|.|.|||  |
eavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentied
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1098-1178 2.4e-09 31.5 In-house 7-91 (283) alignment 
Range on Protein: 1098-1178
Range on HMM: 7-91/283.0
GLQSQFDLLSQVTPDPDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQ-EANGYINASFIS---GFHEKRAFIIAQSPMENTARDL
. . ... | ...  . |.  ..|.  . |||  . .|.. . | |. |.. ||||.||      .... .||||||...| .|.
nnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdf
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1091-1177 2.5e-09 31.6 In-house 15-105 (288) alignment 
Range on Protein: 1091-1177
Range on HMM: 15-105/288.0
DSSTGCSGLQSQFDLLSQVTPDPDDVFTNTAKAYpAKNRSSKFLPVELFLVPLQE-----ANGYINASFISGFHEKRAFIIAQSPMENTARD
 | .. .|...... |...  . ..  .. |.    |||    ||..   | |..      . |||||.| | ..|...| .|.|. .|  |
ksarnrtgfseeynsLaalektksvtagrlavna.kknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvnd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1178-1277 2.9e-09 31.5 In-house 165-260 (290) alignment 
Range on Protein: 1178-1277
Range on HMM: 165-260/290.0
LTDWPQDGVVREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
| .| .  | ....|.|..|. |  ..      ||.||| | .||| .  .. .|       .| | . .| ||.|. .  |.|. .... .  .| ...
lkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivlla

Q
.
i
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 890-1098 7.5e-09 28.6 In-house 130-340 (346) alignment 
Range on Protein: 890-1098
Range on HMM: 130-340/346.0
TLVDFWRLIWQEKpVSIVMVTNLKEGTKSKCEQYWPNKSEEFGPFTVMLISQ---QVYPDFVIRQLNVkIQDGSNDSHTLTQYHLTSWPDHGVPDYATPL
 . ||| .|.||. . .| .    .  |      . ..   .     |.| .   .|  |     ..| . .|  ||     .| . |     |  . |.
fvedfwymiyqeq.ihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytiev.lpegnsdsvicqvhhhapwkhlqqppktlpi

MSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAII--CGETKIPTDKYQTK-
. . .| ..     .  . |    | ||. .||    |..|       .|  |.  ..|||   |... ||  ..  |.. |    |  | | .|.  . 
ikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggkkapvnkdinrf

LQELKEIdsSTGCSG
..|| ||  |  || 
idelaei..spacsp
subfamily_PTPN1_pd Subfamily PTPN1 1179-1268 8.8e-09 29.5 In-house 170-263 (290) alignment 
Range on Protein: 1179-1268
Range on HMM: 170-263/290.0
TDWPQDGVVREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSI
| ||  || . | . |. . .| .    .   ||.|.|||  . ||| .| |   | . ....    ||. .|  ..|. . | . | .|    
ttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfs
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 832-919 9.3e-09 29.2 In-house 33-117 (332) alignment 
Range on Protein: 832-919
Range on HMM: 33-117/332.0
ENSGFNRFKNITVYDDNRIILKPNPNLDmcerEYINASYIDGYSSSNKFIASQGPMK-KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSK
.|  .||   . ..| .|. | |.   |    .. |||..||||  . .| .| |.. .|   |||.. . ||  |... .. |  | |
nnmdmnriphlycfdhsrvelapqdgkd....dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
0038934 (Phosphotyrosine protein) phosphatases II 952-1021 1.3e-08 30.2 In-house 53-135 (194) alignment 
Range on Protein: 952-1021
Range on HMM: 53-135/194.0
LNVKIQDGSNDSHTLTQYHLTSWP------------DHG-VPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAI
||||.    . ..| . |. . ..            |.| ||.... |  |.     .   ..| ..||| ||.|||||..| 
lnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_PTPRN_pd Subfamily PTPRN 1180-1270 1.7e-08 28.5 In-house 196-286 (297) alignment 
Range on Protein: 1180-1270
Range on HMM: 196-286/297.0
DWPQDGVVREPRTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
 ||. ||  .....|.    |  .  .    |.|||||| . |.|||. . . |..  |    .|.    . .|  .|| | | .|.  .. 
swpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_PTPDC1_pd Subfamily PTPDC1 969-1062 1.8e-08 29.0 In-house 85-170 (182) alignment 
Range on Protein: 969-1062
Range on HMM: 85-170/182.0
YHLTSWPDHGVPDYATpLMSLHKqVMaTWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAkregvVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
..  .|.|.||.   . .. . | |. . . ..| . ||| || ||||  ||  .   .      .. .  .. .|..| | .|| .|  ....
vynfgwkDygvasler.iLdivk.vv.afalqegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_PTPN23_pd Subfamily PTPN23 1093-1177 2.6e-08 28.0 In-house 11-98 (288) alignment 
Range on Protein: 1093-1177
Range on HMM: 11-98/288.0
STGCSGLQSQFDLLSQVT-PDPDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQEA-NGYINASFISGFHEK-RAFIIAQSPMENTARD
  | ..|. .| .| |    .  .  .  || |. ||||   || .   | |..  . ||||||. .       ||..|.|...|. |
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnD
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1117-1177 3.1e-08 28.1 In-house 39-104 (318) alignment 
Range on Protein: 1117-1177
Range on HMM: 39-104/318.0
FTNTAKAYPAKNRSSKFLPVELFLVPLQEA-----NGYINASFISGFHEKRAFIIAQSPMENTARD
.  . ..  ||||    |. .   | ||.        ||||..| |...|.|.| ||.|. .| .|
lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieD
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1180-1272 3.3e-08 27.5 In-house 192-279 (290) alignment 
Range on Protein: 1180-1272
Range on HMM: 192-279/290.0
DWPQDGVVREPRTVLQVIDDVihrqqKIGGGPVVVHCSDTVSRSGVYCSVSIGLeQCKAEG-VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||.  |     ..|...  .     .   ||||||||  . |.| . .. .|| |.  .|  .|. .. .|.|.|. ..|    ||  . ...
swpdksvalstlallrtlril.....rkasGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 862-979 4.2e-08 27.6 In-house 12-126 (130) alignment 
Range on Protein: 862-979
Range on HMM: 12-126/130.0
EREYINASYIDGYSSSNKFIASQGPMKKTLVDFWRLIWqEKPVSIVMVTnlkeGTKSKCEQYWPNkSEEFG--PFTVMLISQQVYPDFVIRQLNVKIQDG
. .|||||..     ..... .| |. .| .|||...  |. | ...|     |.  . ..|||. || .      ... . .      |.  |..|.. 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvl....gsveeedeywpd.sePlewyeediivtltdrdefknikasnleiesd

SNDSH-TLTQYHLTSWPDHGV
 |.|| .|| .... ||  | 
lneshqaltmfqisnwpsdgt
PTEN_1 964-1020 4.3e-08 28.2 In-house 92-149 (196) alignment 
Range on Protein: 964-1020
Range on HMM: 92-149/196.0
HTLTQYHLTSWPDHGVPDYATpLMSLHKQVMATWS--PSKGPILVHCSAGVGRTGTFIA
.   .|.  ...|||.|. .  |.   |...  ..  |... .|||| ||.||.|| .|
ksgveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_PTPRA_pd Subfamily PTPRA 1127-1177 9.9e-08 26.2 In-house 61-116 (330) alignment 
Range on Protein: 1127-1177
Range on HMM: 61-116/330.0
KNRSSKFLPVELFLVPL-----QEANGYINASFISGFHEKRAFIIAQSPMENTARD
|||  . || .   | |     .|   ||||||| |..||  || || | |.|  |
knrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetved
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1211-1272 1e-07 26.1 In-house 230-291 (297) alignment 
Range on Protein: 1211-1272
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||||.. .||..
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1181-1279 1.2e-07 25.8 In-house 178-280 (287) alignment 
Range on Protein: 1181-1279
Range on HMM: 178-280/287.0
WPQDGVVRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
||....        | ||.| . .  ...  . ||.|||..  . |||.. .. . ... .  | ||| .|   .|  . . | .  |.  .|. .  | 
wPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy

QMN
. |
ktn
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1126-1177 1.6e-07 25.8 In-house 11-67 (250) alignment 
Range on Protein: 1126-1177
Range on HMM: 11-67/250.0
AKNRSSKFLPVELFLVPLQEAN-----GYINASFISGFHEKRAFIIAQSPMENTARD
 ||| .......   | |.. .      ||||||. |..|..|||..|.|...|  |
eknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatied
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1126-1178 2.3e-07 25.6 In-house 27-84 (284) alignment 
Range on Protein: 1126-1178
Range on HMM: 27-84/284.0
AKNRSSKFLPVELFLVPLQ-----EANGYINASFISGFHEKRAFIIAQSPMENTARDL
 |||  . |. .   | |.     |   |||||||.|.  |  .| .| |..||  |.
dknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladf
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1126-1178 2.3e-07 25.4 In-house 63-120 (319) alignment 
Range on Protein: 1126-1178
Range on HMM: 63-120/319.0
AKNRSSKFLPVELFLVPLQ-----EANGYINASFISGFHEKRAFIIAQSPMENTARDL
 |||  . |. .   | |.     |   ||||||..|.  |  .| || |..||  |.
dknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1213-1272 2.7e-07 24.9 In-house 2-61 (69) alignment 
Range on Protein: 1213-1272
Range on HMM: 2-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1178-1277 3.1e-07 24.7 In-house 178-272 (288) alignment 
Range on Protein: 1178-1277
Range on HMM: 178-272/288.0
LTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
| .|..|||  .  . |.... . .  ||    |.|||.|  | |.|    . | ||. . .  . . .. .  | ..  |..|  ||  .. ..  .| 
lleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_PTPN9_pd Subfamily PTPN9 1085-1178 4.2e-07 24.3 In-house 4-101 (297) alignment 
Range on Protein: 1085-1178
Range on HMM: 4-101/297.0
QELKEIDSSTGCSGLQSQFDLLSQVTPDPdDVFTNTAKAYPAKNRSSKFLPVELFLVPLQ-----EANGYINASFISGFHEKRAFIIAQSPMENTARDL
.|| .   ..| .||. ..  . . ..    . .   .|   ||| .  | ..   | |.     ||  ||||.|. |...|.||| .| |...| .| 
eelvayvkekgkrGlskeyaeirnepveG.tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1117-1178 4.8e-07 23.8 In-house 30-96 (287) alignment 
Range on Protein: 1117-1178
Range on HMM: 30-96/287.0
FTNTAKAY-PAKNRSSKFLPVELF--LVPL--QEANGYINASFISGFHEKRAFIIAQSPMENTARDL
| .. . .   ||| .. ||..    |.    .    |||| ........ ||| ||.|.  | ||.
fkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdf
subfamily_eak_pd Subfamily eak 991-1072 1e-06 22.4 In-house 228-309 (332) alignment 
Range on Protein: 991-1072
Range on HMM: 228-309/332.0
KQVMATwSPSKGPIlVHCSAGVGRTGTFIAIDIA--LEQAKREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVLEAIICGE
|. . |  ||  || . .. |  |.|.|. ||.   | ..|.. .  .  .. . ...|.. | .  |. |....||. .   .
kkyiht.ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1213-1272 1e-06 23.0 In-house 1-60 (69) alignment 
Range on Protein: 1213-1272
Range on HMM: 1-60/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| .
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal
fn3 Fibronectin type III domain 548-640 1.1e-06 21.8 Pfam-A 7-84 (85) alignment 
Range on Protein: 548-640
Range on HMM: 7-84/85.0
SVSSImDTTWAVISWSVPSyiPSDYPIITYEIGYHILKSDNcsmvddneidiQ--MLQLSNSTNgdtFINITGLNDSTCYIFGVRAYIDNGYSKW
|||..  .| ...||| |.  . . ||  ||. |    . .           .    .....|.     ..|||. .| | | |.|. ..|....
svsev.tstsltlsWsppk..dgggpitgYeveyrekggge...........ewkeftvprttt...svtltgLkpgteYefrVqavngagegpe
subfamily_PTPRK_pd Subfamily PTPRK 1126-1177 1.1e-06 22.7 In-house 45-101 (314) alignment 
Range on Protein: 1126-1177
Range on HMM: 45-101/314.0
AKNRSSKFLPVELFLVPLQE-----ANGYINASFISGFHEKRAFIIAQSPMENTARD
.|||| . |. .  .| |.       . ||||..| ...  .|||..| |...| .|
eknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkd
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1178-1275 1.4e-06 22.6 In-house 183-276 (307) alignment 
Range on Protein: 1178-1275
Range on HMM: 183-276/307.0
LTDWPQDGVVREPRTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIGLEQ-CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
 ..||. || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  .. |.  |
wenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_CDC14_pd Subfamily CDC14 981-1022 1.5e-06 22.3 In-house 243-284 (328) alignment 
Range on Protein: 981-1022
Range on HMM: 243-284/328.0
DYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAID
| .||  .. |. ..    ..| | ||| ||.|||||.||  
DGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1201-1272 1.8e-06 21.8 In-house 192-265 (281) alignment 
Range on Protein: 1201-1272
Range on HMM: 192-265/281.0
IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRS-KPGAVTTLEQYTSIYDVI
| |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| . .  .| ||.||  |. |.
ilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1179-1277 1.9e-06 21.5 In-house 189-286 (302) alignment 
Range on Protein: 1179-1277
Range on HMM: 189-286/302.0
TDWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
| |.|. |  .  .. . . .| . ..  .  ..|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|.||.|.| .. .|..
tnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_PTPN13_pd Subfamily PTPN13 1105-1178 2.3e-06 22.1 In-house 19-93 (273) alignment 
Range on Protein: 1105-1178
Range on HMM: 19-93/273.0
LLSQVTPDpDDVFTNTAKAYPAKNRSSKFLPVELFLVPLQEANGYINASFISGFH--EKRAFIIAQSPMENTARDL
 | .. |  |.. .   |.  .|||  . ||..   |.|..  ||||||.|      ..  .|..| |. .|..|.
elrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1179-1277 2.3e-06 21.6 In-house 194-288 (305) alignment 
Range on Protein: 1179-1277
Range on HMM: 194-288/305.0
TDWPQDGVVREPRTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV-DVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
 |||. ||     ..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  .. . .|  .  .. | .||  ...||  |..
idwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1111-1177 4.7e-06 20.7 In-house 29-102 (315) alignment 
Range on Protein: 1111-1177
Range on HMM: 29-102/315.0
PDPDDVFTNTAKA--YPAKNRSSKFLPVELFLVPL-----QEANGYINASFISGFHEKRAFIIAQSPMENTARD
||||   ...|.      |||    ||..   | |     .  . |||||.| .... .|.| .| | . .  |
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvdd
subfamily_CG7180_pd Subfamily CG7180 1124-1175 6.5e-06 20.0 In-house 42-98 (296) alignment 
Range on Protein: 1124-1175
Range on HMM: 42-98/296.0
YPAKNRSSKFLPVELFLVPLQEANG-----YINASFISGFHEKRAFIIAQSPMENTA
   |||  | .| . . | |.. .|     ||||... .|  |...|. . |...| 
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1137-1178 6.5e-06 20.3 In-house 67-108 (315) alignment 
Range on Protein: 1137-1178
Range on HMM: 67-108/315.0
ELFLVPLQEANGYINASFISGFHEKRAFIIAQSPMENTARDL
.| |.  ..   |.||.|| |.  || .| ||.|  .. .|.
qlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdf
PTPc_motif_SM00404 989-1020 8.5e-06 20.7 In-house 68-99 (140) alignment 
Range on Protein: 989-1020
Range on HMM: 68-99/140.0
LHKQVMATWSPSKGPILVHCSAGVGRTGTFIA
  .... .   ..| .|||| ||| |..|.|.
kvldfienaekkggkvlVHCqaGvSRSatlii