Gene PTPRD-6 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP117_AA protein Get Run
AqueP117_AA_1948-2122 phosphatase_domain Get Run
AqueP117_AA_2133-2407 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2144-2410 3.7e-170 558.8 In-house 1-267 (267) alignment 
Range on Protein: 2144-2410
Range on HMM: 1-267/267.0
NEDEECEFQKEFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVI
|||||||..|||||.|..|||.||||.|||..||||||.|.||||..||||||..|..|||||.||||||.|.|||||.||.||.|||.|.||.|...||
nedeeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VLLHPVGTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESAHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLENGNRPIVVACN
|||..|.||.|..||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||.
vlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacs

DGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGMLQHEE
||||.|||||...||.||||||||||||.|.||.||||.||||..|||||.||||.|||||.|..||
dGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlkeee
0050432 (Phosphotyrosine protein) phosphatases II 2123-2406 1.1e-64 214.1 In-house 14-303 (308) alignment 
Range on Protein: 2123-2406
Range on HMM: 14-303/308.0
CGETSFAIEKAQYRIKELRK--KNEDEECEFQKEFELLKELSDtTSTISCSIAMDNQERNRFDYNLPYNHTRVILrDTENDYINASWVEGY--KTGNWFI
...||.  .. ......| |  .. ..   ...||| | .. .   ..|..   .|...||.   ||| |.||.| | ..||||||.| ||  |  . ||
frdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfI

VTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDEI---PQFWPPQMG-QAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNiNT
.|| ||.||  ||| |...||..||| |     ...   .|.||. .| . ..| ..||..  |....|| . ||||.. ...  . || ..|. |  . 
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp.dh

NNKPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGML
.  |....|. .| . .  ... |||| |..||| .|||....  .|. ..||  |.|. ..| |.|||| |  .| |......|.||.. .|
gvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 2138-2402 1.6e-63 210.2 In-house 12-286 (288) alignment 
Range on Protein: 2138-2402
Range on HMM: 12-286/288.0
KELRKKNEDEECEFQKEFELLKELSDTtSTISCSIAMDNQERNRFDYNLPYNHTRVILRD----TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWT
| ..|.  .  . ...||| | .|  .  |.|...   |.|.||.   |||.|.||.|..     ..||||||...||.... ||.|| ||.||  ||| 
klvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWr

MIHQQNCSVIVLLHPVGTDE---IPQFWPPqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF-----KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGI
|...||..||| | ..  ..    .|.||.  |. ..| |.||.   |....|| . |||..      ...  ..|| ..|..|  . .  .....|. .
mvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspellldf

LAKNQLE--NGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
| . .    .|. |.|| |..||| .|||....  .|. ..||. |....... |.||||.|  .| |....|.|.||.
lrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 2143-2402 3.4e-62 205.7 In-house 6-272 (273) alignment 
Range on Protein: 2143-2402
Range on HMM: 6-272/273.0
KNEDEECEFQKEFELLKELSDtTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSV
.. .    ...|||||..| .   |.|...  .|...||.   |||.|.||.| | ..||||||.|.||.... ||.|| ||.||  ||| |...||..|
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVLLHPVGTDE---IPQFWPPQMGQ-AKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGILA----KNQLEN
|| | ..  ..    .|.||. .|.  ..| ..||..  |....|| . ||||.. ...  . || ..|..|  . .  |.|..|. ..     ...  .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp.dhgvppslesllefielvrkalealp

GNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
.| |.|| |..||| .|||....  ... ..||  |... ... |||||| |  .| |....|.|.||.
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRD_pd Subfamily PTPRD 1966-2160 4.4e-62 205.5 In-house 129-321 (564) alignment 
Range on Protein: 1966-2160
Range on HMM: 129-321/564.0
DSNKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGV
. .||..||||| .||.   .....  . ||    |. |.. ..| ..| |. ..... | |||||||     ....|...| ...|.  |.||||||||
gkvkchkYWPekgtety...geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGV

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKNEDEE-CEFQKEFELLKE
|||||||||| ||.|.|.|.|..|| .. ..|.|| ..|||.||||.||. ... ..||.|.  .|. . ....|....||.|  ....||. |. 
GRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLat
0046845 (Phosphotyrosine protein) phosphatases II 2151-2404 8.6e-62 204.4 In-house 2-276 (284) alignment 
Range on Protein: 2151-2404
Range on HMM: 2-276/284.0
FQKEFELLKELSDTTS-TISCSIAMDNQERNRFDYNLPYNHTRVILRD-----TENDYINASWVEGY-----KTGNWFIVTQIPLQNTQTDFWTMIHQQN
...||| |  |  . . ..|....  |...||.   |||.|.||.|.       ..||||||.|.||     .. . ||.|| ||.||  ||| |...||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CSVIVLLHPVGTDE---IPQFWPPQmGQAKKYQDLTVEHSLEKEENDYQIITLELKFK--NESAHNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLE--
..||| | .   ..    .|.||.  |. ..| |.||.   |....|| ..||||...  ..  . || ..|..|  . .  |....|. .| . .    
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp.dhgvppspedlleflrlvrelle

--NGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEG---VSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEG
  .|. |||| | .||| .|||....  .|. ..||   . |... ... |.|||| |  || |....|.|.||.  
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0036941 (Phosphotyrosine protein) phosphatases II 2146-2405 4.1e-61 202.2 In-house 10-280 (297) alignment 
Range on Protein: 2146-2405
Range on HMM: 10-280/297.0
DEECEFQKEFELLKELSDtTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVL
.    ..|||| | .|     ..|...  .|.|.||.   |||.||||.| | ..||||||.|.||. .. ||.|| ||.||  ||| |...||..||| 
lflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

LHPV---GTDEIPQFWPPQMGQAKKYQDLTVEHSLEKE--ENDYQIITLELKF-KNESAHNVTLYYYKKWNIN---TNNKPYLKPLFGILAKNQLENGNR
| ..   |    .|.||. .|. ..| |.||.   ...  ..|| . |||... .|.  . || ..|..|  .   .. ...|. .  .. ...| ... 
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

PIVVACNDGVGCSGTFLTAYSQIERAK---TEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGM
|..| |..||| ||||..|.  ... .   .||  ||.....| |.|||| |  || |....|.| |.    
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2136-2402 4.9e-60 198.3 In-house 13-290 (298) alignment 
Range on Protein: 2136-2402
Range on HMM: 13-290/298.0
RIKELRK-KNEDEECEFQKEFELLKELSD--TTSTISCSIAMDNQERNRFDYNLPYNHTRVILRD----TENDYINASWVEGYKTGNWFIVTQIPLQNTQ
 ...| . |.. .   ...||. |.. |.   . . . . . .|...||.   ......||.|..     | ||||||....||  | ||.|| ||..| 
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

TDFWTMIHQQNCSVIVLLHPVGT---DEIPQFWPPQmgQAKKYQDLTVEHSLEKEENDYQIITLEL-KFKNESAHNVTLYYYKKWNINTNNKPYlKPLFG
.||| |. ... ..||.|...      .....|| .  ....| ..||.   ..|  |. . .|.. | |.|. ..|    . .|  ..  . . . ...
edFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpena.tsvld

---ILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
      ..| ..||.|..| | .||| ||||   .| .||.|.| | |.|| ..  | .|||.|.  |.|....|.  |. 
llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
DSPc_SM00195 2151-2402 1.4e-59 196.9 In-house 2-262 (263) alignment 
Range on Protein: 2151-2402
Range on HMM: 2-262/263.0
FQKEFELLKELSDTTsTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLL
...||| |.|   .. ......   |...||.   |||.||||.| ..|    .|||||....|..  . .|.|| ||..|  |||.|. ......|| |
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

HPVGT---DEIPQFWPPQMGQAKKYQDLTVEHSLEKEEN-DYQIITLELKFKN-ESAHNVTLYYYKKWNINtNNKPYLKPLFGILAKNQLENG--NRPIV
    .    .. ..|| ..|. .......|.   ..... .... ||||.... | ...|| | ||.|. . .     |... .| . . ..   . |||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkkskstssgpiv

VACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
| | .||| .|||.|. . ... ..|   |||. ... |.||||.|. || |....| . ||.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2151-2402 1.4e-59 196.9 In-house 2-262 (263) alignment 
Range on Protein: 2151-2402
Range on HMM: 2-262/263.0
FQKEFELLKELSDTTsTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLL
...||| |.|   .. ......   |...||.   |||.||||.| ..|    .|||||....|..  . .|.|| ||..|  |||.|. ......|| |
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

HPVGT---DEIPQFWPPQMGQAKKYQDLTVEHSLEKEEN-DYQIITLELKFKN-ESAHNVTLYYYKKWNINtNNKPYLKPLFGILAKNQLENG--NRPIV
    .    .. ..|| ..|. .......|.   ..... .... ||||.... | ...|| | ||.|. . .     |... .| . . ..   . |||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkkskstssgpiv

VACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
| | .||| .|||.|. . ... ..|   |||. ... |.||||.|. || |....| . ||.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRD_pd Subfamily PTPRD 2146-2403 1.5e-59 197.1 In-house 20-282 (564) alignment 
Range on Protein: 2146-2403
Range on HMM: 20-282/564.0
DEECEFQKEFELLKELsdTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCS
... .|..|.. ..|   ...|.. . .  |...||..  ..|.|.||.|. .|     ||||||...||.. . .| || ||..|  ||| |. .||.|
nsdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnss

VIVLLHP---VGTDEIPQFWPPQmGqAKKYQDLTVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYKKWNINTNNKpYLKPLFGILA---KNQlENG
.||.|      |.... ..|| . |  ..|..|||. . |.| .||.| |..|| |. .....|. ... .|  .   . . ..|  ..    . . |..
tiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpe.satslLdlirkvraln.epd

NRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
. |||| |. ||| .|||..  . .||.|.|.. ||.|.... |.||. .|.  | ||..|| . |. .
agPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
0040438 (Phosphotyrosine protein) phosphatases II 2149-2403 3.4e-59 196.0 In-house 18-277 (317) alignment 
Range on Protein: 2149-2403
Range on HMM: 18-277/317.0
CEFQKEFELLKELSDTtsTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIV
  ...||| | .|.    |.|...  .|...||.   ||| |.||.| ...    .||||||.|.|.. .. ||.|| ||.||  ||| |...|...|||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

LLHPVGTDE---IPQFWPPqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLE--NGNRPI
 | .   ..     |.||   |. ..| |.||..  |.|...... |||..  ...  . || ..|. |    .  |....|. .| . .    ... |.
mLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp.dhgvppspdllldfleavrealedpggpv

VVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
.| |..||| .|||..||  .|. ..||  |... ... |.|||| |  .| |......|.||  
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
0045450 (Phosphotyrosine protein) phosphatases II 2131-2401 3.6e-57 189.8 In-house 9-303 (307) alignment 
Range on Protein: 2131-2401
Range on HMM: 9-303/307.0
EKAQYRIKELRKKNEDEECEFQKEFELLKELSDT-TSTISCSIAMDNQERNRFDYNLPYNHTRVILRD-----TENDYINASWV--------EGYKTGNW
..| . .......  |    ..|||| |... ..   ..|..    |...||.   |||.||||.| .      ..||||||.|        .||. .. 
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

FIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDEI---PQFWPPQmGQAKKYQDLTVEHSLEKEENDYQIITLELKF--KNESAHNVTLYYYKKWNi
||.|| ||..|  ||| |...|...||| | .   ..    .|.||   |. . | ..||.   |.....|.. |||..   ...  . || ..|..|  
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp.

NTNNKPYLKPLFGILAKNQL--E--NGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGV---SDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
...  |....|. .. . .   |  ... |..| |..||| .|||..||  ... ..||.    |... ... |.|||| |  .| |....|.|.|.
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 2143-2403 6.8e-56 185.3 In-house 26-290 (297) alignment 
Range on Protein: 2143-2403
Range on HMM: 26-290/297.0
KNEDEECEFQKEFELLKELSDTtstISCSIAMDNQERNRFDYNLPYNHTRVILRDTE-----NDYINASWVEGYKT-GNWFIVTQIPLQNTQTDFWTMIH
.. ..   ...||| |..| .    .|..    |...||.   |||.|.||.| . .     .||||||.|.||.  .. ||.|| ||..|  ||| |..
ekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

QQNCSVIVLLHPVGTDE--IPQFWPPQMGqakKYQDLTVEHSLEKEENDYQIITLELKFKNESaHNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLEN-
.|...||| | .   ..   .|.||. .|   .| |.||.   ......| . |||.. ..|| . || . | .|    .  |.|. |. .| . .  . 
eqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges.rtvthfqytgwp.dhgvppslellleflelvreala

---GNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
   ...|..| |..||| .|||..||  .|. ..||  |... ... |.|||| |  .. |......|.|.  
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1964-2142 8e-56 184.4 In-house 125-304 (305) alignment 
Range on Protein: 1964-2142
Range on HMM: 125-304/305.0
TTDSNKCAQYWPEKVNETHKLdDGIIIRTKTEEVHCWYTKRQLLITK-DDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPK-GPPLVVHC
  . .|| |||||...|.... . ...  | |.    |..|.| |.. |.|. | ....|||| |||||||     ..|.|.... ..    | ||.|||
eggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhC

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRK
||||||||.||..| .|.|.|.|....... | |.|..|. .|||..|| ..|  |.. |.||.||  ..  . |.. |.|
sagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklkk
0043336 (Phosphotyrosine protein) phosphatases II 2143-2401 1e-55 184.5 In-house 14-276 (278) alignment 
Range on Protein: 2143-2401
Range on HMM: 14-276/278.0
KNEDEECEFQKEFELLKELSDttSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQ
.. ..   ...||| | .      |.|... ..|...||.   |||.|.||.| ...    .||||||.|.||. .. ||.|| ||..|  ||| |....
lllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel

NCSVIVLLHPVGTDE---IPQFWPpqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNinTNNKP-YLKPLFGILA--KNQL
....|| | .   ..     |.||   |. ..| |.||.   |....|| ..|||..  ..   . || |.|..|    .. |  |..|. .|   ...|
gvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavreal

ENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
|. | |..| |..||| .|||...|  .|....||  |... ... |.|||| |  .. |....|.|.||
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2143-2403 1.6e-55 183.2 In-house 14-279 (287) alignment 
Range on Protein: 2143-2403
Range on HMM: 14-279/287.0
KNEDEECEFQKEFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSV
 ..  . .|.. | .|......   .  .|| .|...||.   |...  ||.|.....|||||....|||  . ||... |. ||  .|| .|...| ..
ghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvta

IVLLHP---VGTDEIPQFWPPQMGqaKKYQDLTVEHSLEKEENDYQIITLELKFKN--ESAHNVTLYYYKKWNINTNNKPYLKPL--FGILAKNQLENGN
||.|       ..   |.|| .      . . ..|   |. ...| . .||.| ||  .. ..|. | . .|. . . . .   |  .    |.|  .||
ivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgn

RPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 .||| | |.|| |..|. |   |...||||| |.|| ... | |.|| |   |.|..  ... || .
tsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2145-2403 4.8e-55 181.5 In-house 16-284 (290) alignment 
Range on Protein: 2145-2403
Range on HMM: 16-284/290.0
EDEECEFQKEFELLKElSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILR------DTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQ
   .  |...|. |.  ..   |.   .. .|...|||.  ..|.  |..||      | .|.||||....|||  . .|.|| |..||  ||| .| |.
akgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

NCSVIVLLHPVG---TDEIPQFWPPQmgQAKKYQDLTVEHSLEKEENDYQIITLELKFKNE--SAHNVTLYYYKKWNINT--NNKPYLKPLFGILAKNQL
....||.|  .    ...  |.|| .  ..|.|.  ... . |.. |.| ...||.| ||.  ....|| |  . |. .   .|.     ..    |.| 
kvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqr

ENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 .||..||| | |.|| |..|..|.  |...||||| |.|| ... |.|.||.|   ..| . .... .| .
krgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
Y_phosphatase Protein-tyrosine phosphatase 2176-2399 8.2e-55 181.1 Pfam-A 1-234 (235) alignment 
Range on Protein: 2176-2399
Range on HMM: 1-234/235.0
NQERNRFDYNLPYNHTRVIL--RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGT---DEIPQFWPPQMGQAKKYQD
|...||.   |||..||| |  .....|||||..|.|||. . ||.|| ||..|  ||| |. |....|||.|  .      ...|.|| .... ..|.|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LTVEHS-LEK-EENDYQIITLELKFKNESA--HNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLEN--GNRPIVVACNDGVGCSGTFLTAYSQIERAKT
..||    || .|..|.. .|||| |.|.   . |. . |..|. . . .   |.|. .. | . ..   . |.|| | .||| .|||...   .|....
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLC
|.  |..|.... |.||||.|. || ||...... 
eeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 2176-2399 8.2e-55 181.1 In-house 1-234 (235) alignment 
Range on Protein: 2176-2399
Range on HMM: 1-234/235.0
NQERNRFDYNLPYNHTRVIL--RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGT---DEIPQFWPPQMGQAKKYQD
|...||.   |||..||| |  .....|||||..|.|||. . ||.|| ||..|  ||| |. |....|||.|  .      ...|.|| .... ..|.|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LTVEHS-LEK-EENDYQIITLELKFKNESA--HNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLEN--GNRPIVVACNDGVGCSGTFLTAYSQIERAKT
..||    || .|..|.. .|||| |.|.   . |. . |..|. . . .   |.|. .. | . ..   . |.|| | .||| .|||...   .|....
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLC
|.  |..|.... |.||||.|. || ||...... 
eeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2146-2403 2.1e-54 179.7 In-house 20-284 (319) alignment 
Range on Protein: 2146-2403
Range on HMM: 20-284/319.0
DEECEFQKEFELLKELSDTtsTISCSIAMDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCS
  |  ..|||.|||| ...  |.. .   .|...||.   |.|..|||.| .     . ||||||...||.  . || || ||.||  ||| |. ....|
tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

VIVLLHPVGTD---EIPQFWPpqMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESA--HNVTLYYYKKWNIN---TNNKpYLKPLFGILAKNQLEN
..|.|  .      .. ..||    . ..|  |.|.   |.| .|| |  |.|. |..     .|. ..|..|  .   .. .  |  |.. ..| . ..
ivvmltklveklkvklkkywp..eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat.slldllkrirksrekt

GNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 ..|||| | .|||  |||..    .|| | ||| |.|..... | ||. .|.  | |....| | |..|
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2139-2401 5.4e-53 174.9 In-house 11-278 (288) alignment 
Range on Protein: 2139-2401
Range on HMM: 11-278/288.0
ELRKKNEDEECEFQKEFELLKELSDTTSTISCSIAmDNQERNRFDYNLPYNHTRVILRD----TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTM
   ||. ... .|..|.. | .|  | |.   . |  |...||.   |||...|| |..    ...||||||...|.|  . .| || ||..|  ||| .
kvakksarnrtgfseeynsLaalektksvtagrla.vnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IHQQNCSVIVLLHPV---GTDEIPQFWPpQMGQAKKYQDLTVEHSLEKEENDYQIITLELKfKNESAHNVTLYYYKKWNINTnNKPYLKPLFGILAKNQL
..... | || |  .   |  .  ..|| . .. |.| ..||.   .||..|.   .|.|. |...  ..| | |. |  .       .||...| . . 
vyenktstivmltelveggktkCeeYWP.dadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhg.vPeskapllellrqvkv

ENG--NRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
 |     ||.| | .||| .|||...   |.. ..| . |.. .. | | ||. ||. |..|....| | . 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2148-2403 6.7e-53 174.8 In-house 19-281 (318) alignment 
Range on Protein: 2148-2403
Range on HMM: 19-281/318.0
ECEFQKEFELLKELSDTTSTISCsIAMDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVI
| ....|.| |.  ..|....   .   |. .||.   |.|.|||| |...    . |||||....||.  . .| .| || .| .||| |. .||..||
elllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavi

VLLHP---VGTDEIPQFWPPQmgQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESA-HNVTLYYYKKWNINT--NNKPYLKPLFGILAKNQLENGNRP
|.|      | . . ..|| .  ....|..|.|| . |.| .|| . ..... ..|..  .|  | | .|  .   ..   |  | .   | |...|..|
vmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

IVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
||| |  |||  |.|..  ...||.| |.. |.||.... |.||. .|   ..|..... | |. .
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2147-2403 6.1e-51 168.4 In-house 20-284 (305) alignment 
Range on Protein: 2147-2403
Range on HMM: 20-284/305.0
EECEFQKEFELLKELsDTTSTISCSiaMDNQERNRFDYNLPYNHTRVILRDT--E--NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSV
.. ........| |. ...  . ..    |...||.  . .... |.||. .  .  .||||||.|.|||  . .||.| ||.|| .||| .| .   |.
sdkgleaqykslyee.eesidvgkk..eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

IVLLH---PVGTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKF--KNESAHNVTLYYYKKWNINT--NNKPYLKPLFGILAKNQLENGN
||.|      | |   |.|| .... |......|| . ||. .|| .  |.. .  ...  ..|. |   .|  .   .    |  |.  . |.| .. .
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

RPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 |..| |..||| .|.|..   ..||.|.|.| |.|. ....||.|...|  |..| ..|. | |. .
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2174-2403 8.4e-51 167.6 In-house 7-243 (250) alignment 
Range on Protein: 2174-2403
Range on HMM: 7-243/250.0
MDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGT--DEIPQFWPpqMGQAKK
..|.|.||.   ......||.|  .    | ||||||...||.  . ||.|| |||.|  ||| |. ... ..||.|  .     ...|.||  . .|.|
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywP..vekaek

YQDLTVEHSLEKEENDYQIITLELKFKNESAH-NVTLYYYKKWNINTN---NKPYLKPLFGIlAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAK
| |.||.   ..|  ||.. .| |  .... .  |  . .  |   .     .  |. |  .  ..| . ||.|..| |  ||| ||.|.. .. .||.|
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkv.qasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

TEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
.| | |.|..|.. | .||. |. ||.|....|.. .. .
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
0040439 (Phosphotyrosine protein) phosphatases II 2167-2401 1e-49 164.8 In-house 2-245 (249) alignment 
Range on Protein: 2167-2401
Range on HMM: 2-245/249.0
TISCSIAMDNQERNRFDYNLPYNHTRVILRDTEN----DYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTD---EIPQFWP
..|... . |...||.   |||.|.||.| ....    ||||||...||. .. ||.|| ||..|  ||| |.......||| | .          |.||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

PqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLEN----GNRPIVVACNDGVGCSGTFLT
.  |. ..| |.||.   .....|| . ||||.. .. . . |. ..| .|   ..  |....|. .. . .  .     . |..| |..||| .|||..
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

AYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
||  .|. ..|.  |... ... |||||| |  .| |....|.|.|.
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0050432 (Phosphotyrosine protein) phosphatases II 1966-2126 5.6e-49 162.5 In-house 146-304 (308) alignment 
Range on Protein: 1966-2126
Range on HMM: 146-304/308.0
DSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppKGPPLVVHCSAGV
. .|||||||...... .  ... .... |||. .||.|.| .|. .|. |  .||.. | ||||||| .   ...|.. .| ..  .|.| ||||||||
grekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGv

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGET
|||||||..|..|.....|....... . ..|.||   |||.|||..... |...... .|
GRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
subfamily_Ptp69D_pd Subfamily Ptp69D 2139-2403 8.9e-49 161.3 In-house 12-287 (307) alignment 
Range on Protein: 2139-2403
Range on HMM: 12-287/307.0
ELRKKNEDEECEFQKEFELLKELsDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTM
.|.....| .  ..||.| |..   .  . . |   .|. .||..   ....|||.|. .    . ||||||...|||  . ||. | |...|  ||| |
alksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRm

IHQQNCSVIVLLHPVGTD---EIPQFWPPQmgQAKKYQDLTVEHSLEKEENDYQIITLELKFKN------ESAHNVTLYYYKKWNiNTNNKPYLKPLFGI
| .|.  .||.|  ..     .....|| .  . ..|.|. |.   |.. .|| | .|..  |.      |  ..|. | |. |. ...     . |. .
iaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllkl

LAKN--QLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
. .     .. . |||| |. ||| ||.|..  | ... |.|   |||..... ||||. ||. || |....  | .| .
ieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
0042113 (Phosphotyrosine protein) phosphatases II 2169-2402 1.3e-48 161.0 In-house 2-243 (245) alignment 
Range on Protein: 2169-2402
Range on HMM: 2-243/245.0
SCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPPq
|... . |...||.   |||.||||.| ...    .||||||.| ||.  . ||.|| ||..|  ||| |........|| | .   ..    .|.||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

mGQAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNINTNN--KPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQ
 |. ..| |.||.   |. ..|| . |||..  ..   ..|. |.|  |  ..      .|  .. .. | . |..| |..| |..||| .|||..||  
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

IERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
.|....|.  .... ... |||||| |  .. |....|.|.|. 
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 2151-2405 1.8e-48 160.7 In-house 9-275 (278) alignment 
Range on Protein: 2151-2405
Range on HMM: 9-275/278.0
FQKEFELLKELSDTtSTISCSIAMDNQERNRFDYNLPYNHTRVIlrdtenDYINASWVEGYktGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV-
.. ||| |  |..  |.|....  .|...||.   |||.|.||.      ||||||...||  .. ||.|| ||..|  ||| |.......||| | .. 
lllefefllllgip.seitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

--GTDEIPQFWPPqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF-----KNESAHNVTLYYYKKWNINTNNKPY-LKPLFGILA----KNQ-------
  |    .|.||.  |. . | |.||.   |.. .|| ..||..       ..   ..|| ..|. |  ..      ||... .|      ..       
elgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

----LENGNRPIVVACNDGVGCSGTFLTAYSQIERAktEGVSDIFQFIRKARSQRPG-LVDCLERYIYCHELLCEYAEGM
    |.... |..| |. ||| .||.  ||  .|.   ||. |... ... ||||||  |  || |....|.|.|. . .
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0040438 (Phosphotyrosine protein) phosphatases II 1966-2140 4.2e-48 159.6 In-house 124-295 (317) alignment 
Range on Protein: 1966-2140
Range on HMM: 124-295/317.0
DSNKCAQYWPEkvNETHKLdDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGV
. .|||||||.  .|| .  ........ ||..  .| |.| .....|| |  .||.. | ||||||| .   ...|.. .|   ...| |..|||||||
grekcaqYwpl..getlty.gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGv

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKEL
|||||||....||.....|....... . ..|.||   ||| |||..... |........|.  . .  .....|
gRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkl
subfamily_PTPRB_pd Subfamily PTPRB 2138-2403 4.9e-48 158.6 In-house 14-286 (293) alignment 
Range on Protein: 2138-2403
Range on HMM: 14-286/293.0
KELRKKNEDEECEFQKEFELLKELSDTTStISCSIAMDNQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWT
. ..|...|....|..|.| ||..  ... .... .. |...||.   |||.|.|| |     ....|||||....||.. . ||.|| || .|  ||| 
ehvkkmkadsdlrfseeyeelkavgkdqa.vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWr

MIHQQNCSVIVLLHPV---GTDEIPQFWPPQMgQAKKYQDLTVEHSLEKEENDYQIITLELKFkNESAHNVTLYYYKKWN---INTNNKPYLKPLFGILA
|......|.||.|  .   |     ..|| .  ..  | |..|.   |.| .|. | .|...  ... ..|. | .. |    .  . |. |. .  .  
mvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvre

KNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
. . .. .||||| |  ||| .|||..    ... ..| . ||| .. . |..|  ||   ..||. |. . .. .
aiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2132-2400 8e-48 158.4 In-house 17-289 (319) alignment 
Range on Protein: 2132-2400
Range on HMM: 17-289/319.0
KAQYRIKELRKKNEDEECEFQKEFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNT
.|.|. .  ... .|.  ... ||  . .|.   .. . .   .|...||.   |......| |. ..     ||||||.|.||.  . .| .| ||.||
payyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldnt

QTDFWTMIHQQNCSVIVLLHpvgTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEEndYQIITLELKF--KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGI
  ||| || ..||| ||||     |   |.|| .. . ..  .. |.   | .|  | .  .||    |..   ..| .... |  .     |  .|. .
ladfWrmiweyncstivllt...kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwp.dvGvpdypsdlmrl

LAK----NQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
. |    .. ||....||| |  ||| .|....    ..| | |   |...|.|  | ||. ||. | .| ...  | |
vkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1968-2146 1e-47 157.8 In-house 129-305 (318) alignment 
Range on Protein: 1968-2146
Range on HMM: 129-305/318.0
NKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTH-PPKGPPLVVHCSAGVG
.|...|||.|  ...   . . .  | |     |. |.. .|... . |  .  |. | |||.||| .   ..... ... .. ...  |.|||||||||
akvhryWPskgsrsy...gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvG

RTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKNED
|||.||..|..|.|.|.|........  |.|.||  .|||..||..|.. | . ...|.|    .. . ||.|||... .
rtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpe
subfamily_PTPN23_pd Subfamily PTPN23 2137-2407 2.1e-47 156.3 In-house 3-285 (288) alignment 
Range on Protein: 2137-2407
Range on HMM: 3-285/288.0
IKELRKKNEDEECEFQKEFELLKELSD-TTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTG-NWFIVTQIPLQNTQTDFWTM
..||..|  |.. ...|.|..|..  |  .   |..||  . |.||.   |||.|.|| ||....||||||.|..  .|   ||.|| |||.|  ||| |
veelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlm

IHQQNCSVIVLLHPVGTDEI---PQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESA-HNVTLYYYKKWNIN-TNN--KPYLKPLFGILA
...|  ||||.|.     .     ..|| . |...|..||.|  . ..| . .   .|.|......| ..|..  ...|      .  . .|. |  . .
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeves

--KNQLENGNRPIVVACNDGVGCSGTFLTAYSQIER-AKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGMLQ
  ... .. . |.|| |  ||| .|.|   |. ..   | .|. || | ... | ||   |   |..  . |   |.|. .|.
ayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvld
0046845 (Phosphotyrosine protein) phosphatases II 1966-2125 7.4e-47 155.4 In-house 115-278 (284) alignment 
Range on Protein: 1966-2125
Range on HMM: 115-278/284.0
DSNKCAQYWPEKvNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDD-DSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP--PKGPPLVVHCS
. .|||||||.. .|. ...| ...... |||. .||.| | .|. . .. |. .||.. | ||||||| .   ...|.. .|  ..  |.|.| |||||
grekcaqYwple.gevltygd.ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs

AGVGRTGTFIVIDTMLQRMKQEN---TLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGE
||||||||||..|..|.....|.   ...... . ..| ||   ||| |||..... |....... 
aGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_PTPRG_pd Subfamily PTPRG 1959-2132 7.5e-47 154.8 In-house 121-298 (563) alignment 
Range on Protein: 1959-2132
Range on HMM: 121-298/563.0
YITK-ITTDSNKCAQYWPEkvNETHKLdDGIIIRTKTEEVHCWYTKRQLLITK-----DDD-SMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP
 ||.      .|| .|||.  .|. .. . . .. ..|||.. ||.|.| | .      ..      ...|. | |||||||  ..  ..|.     ...
mitnlvergrrkcdvYWPk..desety.galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaank

PKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEK
 .  |.|||||||||||||.||.||.|....|||. |...|| .|| ||  ||||.||||..|. | . |. .||    |.
aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq
0051299 (Phosphotyrosine protein) phosphatases II 1966-2121 1.9e-46 154.2 In-house 130-286 (288) alignment 
Range on Protein: 1966-2121
Range on HMM: 130-286/288.0
DSNKCAQYWPEkvnETHKLDDGIIIRTKTEEVHCWYTKRQLLITKD----DDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHC
. .|||||||.   ....  . | .... |||.  ||.|.| .|.      |. |  .||.. | ||||||| .   ...|.  .|  ....|.| ||||
grekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHC

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
|||||||||||..|..|.....|......... ..|.||  .||| |||..... |....
saGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1969-2146 2.7e-46 153.1 In-house 132-308 (319) alignment 
Range on Protein: 1969-2146
Range on HMM: 132-308/319.0
KCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSM-SMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPP-KGPPLVVHCSAGVG
|. .||||.  |.      .|.  . ||    | .|.| . |  . . .  ..|.| | ||||.|| .   .. .. .|| ..   .  |.|||||||||
klkkywpeenfeey...GrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvG

RTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKNED
|||||||.| ||.|.|.|..|... .  ..| || ..||..|||..|.. | . ...|.| . ... . |.|.|..|. |
RtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvad
subfamily_PTPRG_pd Subfamily PTPRG 2144-2401 2.8e-46 152.9 In-house 14-286 (563) alignment 
Range on Protein: 2144-2401
Range on HMM: 14-286/563.0
NEDEECEFQKEFE-LLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTEN-----DYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQ
  |..  |..||| | .|  ... ... | . .|...||    ..|...|| |... .     |||||....||. .. ||.|| ||..|  ||| || .
hadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWe

QNCSVIVLLHP---VGTDEIPQFWPPqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF---K--N--ESAHNVTLYYYKKWNiNTNNKPYLKPLFGILA
|| ..||..      |  . ...||    ....|. |.|    |.    |.. || .|    |  .  .. ..|. | | ||  ...   .  |      
qnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP.dhgvPehslpvLifvk

KNQLENGN--RPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
|..  | .   |||| |. ||| .||..   . ... ..| . ..|.|... |.||. ||   | ||. |. | | 
kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
0036941 (Phosphotyrosine protein) phosphatases II 1966-2128 3.3e-46 153.3 In-house 116-284 (297) alignment 
Range on Protein: 1966-2128
Range on HMM: 116-284/297.0
DSNKCAQYWPEKVNETHKLdDGIIIRTKTEEV--HCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP--PKGPPLVVHC
. .|||||||....|. .  ..........||  . .|| |.| .|. ... |  .||.. | ||||||| .   ...||. .|  ..  |.|.| .|||
grekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHC

SAGVGRTGTFIVIDTMLQRMK---QENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSF
||||||.||||..|.|||...    |....|.......|.||   ||| |||....  |........| .
saGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
0047943 (Phosphotyrosine protein) phosphatases II 1966-2120 1.8e-45 150.9 In-house 115-271 (273) alignment 
Range on Protein: 1966-2120
Range on HMM: 115-271/273.0
DSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPP--KGPPLVVHCSA
. .|||||||....|...  . ...... ||.. .||.|.| .|. ... |  .||.. | ||||||| .   ...||. .| ..    ...| ||||||
grekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsa

GVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
|||||||||..|..|.... |....... . ..| ||   ||| |||..... |...
GvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2140-2402 2.8e-45 149.8 In-house 14-288 (325) alignment 
Range on Protein: 2140-2402
Range on HMM: 14-288/325.0
LRKKNEDEECEFQKEFELLKelSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMI
. ||. ...  | .||.||   || . .   .   .|...|||   ......||.|     |.. ||||||... .|  . |. .| || .|  |.| ..
vekkkaqdqdgfahefgllp..sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlv

HQQNCSVIVLLHPV--GTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNES-AHNVTLYYYKKWN-INTNNKP-YLKPLFGILAK--
 . .|||.|.|  .  | |.  ..|| .||..|..  | |.    .|  ||    |..|  ..  .  |  . .. |. . ....|  | ..  .. .  
ldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs

NQL---ENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
...    ..  ||.| | .||| .|.|.. || ...  .|   |||.|..| | .|| .|.. ..|| ..| | |. 
ervtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPRA_pd Subfamily PTPRA 1966-2134 3e-45 149.5 In-house 139-308 (330) alignment 
Range on Protein: 1966-2134
Range on HMM: 139-308/330.0
DSNKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSM----SMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHC
. .|||||||..   |.     | .  . |.|   || |..|...  |..    |  .. . .| ||| |||.. | |.... ... ... .. |.||||
keekcaqywPdeGlvty...GnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhc

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQ
||||||||||||.|..|.|.| |. .....|. ..| ||  .|||.||| .|.| | ..   |.| . .   .
saGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2154-2400 1.7e-44 147.4 In-house 3-253 (284) alignment 
Range on Protein: 2154-2400
Range on HMM: 3-253/284.0
EFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHpv
||  . .|.  ... . .   .|...||.   |......| |. .      ||||||...||.  . .| || ||.||  ||| || ..||| ||||   
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

gTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEEndYQIITLELKF--KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGILAK----NQLENGNRPIVVACN
  |   |.|| .. . ..  .. |.   | ||  | .  .||    |..   ... .... |  .     |  .|. .. |    .. ||....||| | 
.kdkcsqywplkivikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwp.dvgvpdypsdlmrlvkkvrhltskenhranivvhcs

DGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
 ||| .|....    ..| | |   |...|.|. | ||. ||. | .| ...  | |
agvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPRA_pd Subfamily PTPRA 2138-2401 2.6e-44 146.4 In-house 21-294 (330) alignment 
Range on Protein: 2138-2401
Range on HMM: 21-294/330.0
KELRKKNEDEECEFQKEFELLKElSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWT
.|.|..  |.   |..||. |   ..  .|.  .   .|.|.||.   |||...||||       | ||||||...|||  . || .| |...|  ||| 
eeirirsaddnklfreefnalPa.gpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwr

MIHQQNCSVIVLLHPV---GTDEIPQFWPPQmGqAKKYQDLTVEHSLEKEENDYQIITLELK-----FKNESAHNVTLYYYKKWN---INTNNKPYLKPL
|| .|. . ||.|  .     .   |.|| . | .  | ...||   |.. .|| .  . ..      .....  |. .... |    . .. .  || |
miweqksativmltelkerkeekcaqywPde.G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkll

FGILAKNQLEnGNrPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
  . ..|| . .. |||| |  ||| .|||..  . .|| |.|.. |.|.|... | ||| .|  .|.| .... | ||
kkvkklnqqs.ag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
DSPc_SM00195 1962-2121 3.7e-44 146.4 In-house 102-262 (263) alignment 
Range on Protein: 1962-2121
Range on HMM: 102-262/263.0
KITT-DSNKCAQYWPEKVNETHKLDdGIIIRTKTEEVHC-WYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
.  . ...||..||||. ... . .  | . .. .| .  ....|.| .||.... .  .|.|| . ||||||| ..  .....  .. ..  . .|.||
eeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
||||||||||||..||..|.....|....| . . ..|.||. .|||.|||..|.. ... |
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1962-2121 3.7e-44 146.4 In-house 102-262 (263) alignment 
Range on Protein: 1962-2121
Range on HMM: 102-262/263.0
KITT-DSNKCAQYWPEKVNETHKLDdGIIIRTKTEEVHC-WYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
.  . ...||..||||. ... . .  | . .. .| .  ....|.| .||.... .  .|.|| . ||||||| ..  .....  .. ..  . .|.||
eeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
||||||||||||..||..|.....|....| . . ..|.||. .|||.|||..|.. ... |
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_CG7180_pd Subfamily CG7180 2143-2401 6.8e-44 144.7 In-house 11-289 (296) alignment 
Range on Protein: 2143-2401
Range on HMM: 11-289/296.0
KNEDEECEFQKEFELLKELSdtTSTISCSIAMDNQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQ
| .. . |...|..| ..|.  . .  . .  .|.|.||    .||...||.|.    . ..|||||..|...   . .|||. | ..|  .||......
krrkfrveyklelkltprle..igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvyde

NCSVIVLLHPVGTDE--IPQFWPPQMgqAKKYQDLTVEHSLEKEENDYQIITLELKFK---------NESA--HNVTLYYYKKWNINtNNKPYL-KPLFG
..| .| |  ..  .   |..||...   ..|... ||   ||.  . .| |. |. |         ...|    |.|. ...|... .. |.  . |  
eisavvvLtktfdfakmypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWele.dkvPlstnalie

ILAKNQ-------LENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
.. . .        .. . |.|| ..||.. || .|..   .| .. |.  |.|..... | .||.||.  | | |. ..| |.
lrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_PTPRB_pd Subfamily PTPRB 1966-2125 9.4e-44 144.6 In-house 132-289 (293) alignment 
Range on Protein: 1966-2125
Range on HMM: 132-289/293.0
DSNKCAQYWPEKVNEThkLDDGIIIRTKTEEVHCWYTKRQLLITKddDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTH--PPKGPPLVVHCSA
   || .|||.. ...  |   | .  ..||.   .. |.|.|.|  ..... ...|. | ||||||| .   ...|. ..| ..    .  |.||||||
gkvkCeeYWPadeepv..lyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsa

GVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGE
||||||||| .|..||....|....|. .. ..|..| .||||..|||.||... | .. .|
GvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2149-2402 1.3e-43 144.0 In-house 6-266 (283) alignment 
Range on Protein: 2149-2402
Range on HMM: 6-266/283.0
CEFQKEFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVE---GYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVL
 ...  .| ||.||       .. | .|.. ||..  .|..  || |.   .|||||...     || .. .|..| ||..|. ||| |..... . ||.
nnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm

LHPVGTDE---IPQFWPPQmGqAKKYQDLTVEHSLEKEENDYQIITLELKFK--NESAHNVTLYYYKKWnINTNNKPYLKPL--FGILAKNQLENGNRPI
| ..  |.     |.|| . | ...| ..||    |  .| . |  | |. .   .|.  .. | .  | .. .... .  |  |  .  .| |. . ||
ltklqedlrikCsqyWPkr.G.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPi

VVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
|| |  |.| ...|..| . .. |.|| | |.|. ..  | ||...|  |..|   |||  | |
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1965-2127 2.5e-43 143.5 In-house 136-296 (298) alignment 
Range on Protein: 1965-2127
Range on HMM: 136-296/298.0
TDSNKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKG-PPLVVHCSA
.|  |. .|||.. .||.   . | .. . .|..  ...|.| ..| . . .  . . . |.|||.|||  .  .. .....| ..   |  |..|.|||
ldktkyhkywPdegkety...geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsa

GVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETS
||||.||||.||..|.|.|.|... ... .  .|..|...|||.|||..|..   . ...... 
GvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
0043336 (Phosphotyrosine protein) phosphatases II 1965-2120 4e-43 143.3 In-house 125-276 (278) alignment 
Range on Protein: 1965-2120
Range on HMM: 125-276/278.0
TDSNKCAQYWPekvnETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAG
 ...|||||||    ....  ... .... ||.. .|| |.| .|.  |. |  .|||. . ||||||| .   ...|.  .|   .... |..||||||
lgrvkcaqYwp....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaG

VGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
||||||||.....|.... | ...... . ..|.||   ||| .||..... |...
vgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
Y_phosphatase Protein-tyrosine phosphatase 1959-2118 7.8e-43 141.9 Pfam-A 72-234 (235) alignment 
Range on Protein: 1959-2118
Range on HMM: 72-234/235.0
YITKITT-DSNKCAQYWPEKVNETHKLDDGIIIRT-KTEEVHCWYTKRQLLITKDDDS-MSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGP
 .|. .  ...||||||||. .|. . .|  .  . |..| .  || |.| ..|....  .  ......| ||||||| ..  ....|.... .. .|  
mltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksg

PLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
|.||||||||||||||...|..|.....|......... ..|.||. .||. ||||...| ..
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1959-2118 7.8e-43 141.9 In-house 72-234 (235) alignment 
Range on Protein: 1959-2118
Range on HMM: 72-234/235.0
YITKITT-DSNKCAQYWPEKVNETHKLDDGIIIRT-KTEEVHCWYTKRQLLITKDDDS-MSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGP
 .|. .  ...||||||||. .|. . .|  .  . |..| .  || |.| ..|....  .  ......| ||||||| ..  ....|.... .. .|  
mltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksg

PLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
|.||||||||||||||...|..|.....|......... ..|.||. .||. ||||...| ..
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0037934 (Phosphotyrosine protein) phosphatases II 2168-2401 8e-43 142.1 In-house 2-241 (243) alignment 
Range on Protein: 2168-2401
Range on HMM: 2-241/243.0
ISCSIAMDNQERNRFDYNLPYNHTRVILRDteNDYINASWVEGYKtgNwFIVTQIPLQNTQTD----FWTMIHQQNCSVIVLLHPV---GTDEIPQFWPp
.|... . |...||.   |||.|.||.| .  .|||||.......  . .|.|| ||..|  |    || |.......||| | .    |    .|.|| 
fsiallpenlsknrysdilpydhsrvkleg..sdyinanliyvtp..r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

qmGQAkKYQDLTVEHSLEKEENDYQIITLELKFKNESAHNVTLYYYKKWNINTNNKPY-LKPLFGILAKNQ----------LENGNRPIVVACNDGVGCS
  |.   | |.||.   |.. .|| . ||.|. .... .  . . |  ...  .. |   ..|  .| . .           .....|..| |  ||| .
..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFLTAYSQIERAkteGvSDIFQFIRKARSQRPG-LVDCLERYIYCHELLCEY
||...||  ...    |  |... ... |.||||  |  .. |....|.|.|.
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRK_pd Subfamily PTPRK 2147-2400 8.2e-43 141.4 In-house 20-275 (314) alignment 
Range on Protein: 2147-2400
Range on HMM: 20-275/314.0
EECEFQKEFELLKELsdttstISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSV
|   |..|.| | |         ..   .|.|.||.   |.|...||.|  ..    .|||||.....||  . ||||| |||.| .||| .....||. 
egygfkeeyeslfeg......wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencas

IVLLHPVGTDE---IPQFWPPQmgqAKKYQDLTVEHSLEKEENDYQIITLELKF---KNESAHNVTLYYYKKWNINtNNKPYLKPLFGILAK--NQLENG
||.|  .         ..|| .   ...|.|. ||    . .... . .. ..    . |  . |  . . .|    .   . . |......  .. |..
ivmltelvevgrvkClkyWPed...tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqeee

NRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
. .||| |  | | .|||..  . .. ...||| |.|. ... ||... .|.  |.|..... . |
aGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPN6_pd Subfamily PTPN6 2126-2404 9.1e-43 141.4 In-house 2-299 (306) alignment 
Range on Protein: 2126-2404
Range on HMM: 2-299/306.0
TSFAIEKAQYRIKELRKKNED-EECEFQKEFELLKEL-SDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRD---TENDYINASWVEGYKT--GNWFI
||.  .. . |..||.|..|. |   |..||| |..  . .. . . .  ..|.|.||.   ||..||||||..   ...|||||. ...  .   . .|
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyi

VTQIPLQNTQTDFWTMIHQQNCSVIVLLHP---VGTDEIPQFWPPQMGQAKkYQDLTVEHSLEKEENDYQIITLELK--FKNESAHNVTLYYYKKWN-IN
 ||  |..| .||| |. |.|. |||..      | .   ..|| .  . . | ...|..  ||. .||.. .| ..   |......|  | .|.|   .
atqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhg

TNNKPY--LKPLFGILAKNQLEN--GNRPIVVACNDGVGCSGTFLTAY---SQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEG
. ..|.  |. |  . .|..  .   ..|||| |..|.|  |||.      ..||. ...   || ......|.|| |||   . | . .. . .| | 
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
0039614 (Phosphotyrosine protein) phosphatases II 1960-2124 1.1e-42 141.9 In-house 132-292 (297) alignment 
Range on Protein: 1960-2124
Range on HMM: 132-292/297.0
ITKITTDSNKCAQYWPEKVNethkLDDGIIIRTKTEEVHCWYTKRQLLITKddDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP--PKGPPL
.|| . ...||||||||...      ... ......|..  || |.| .|.  .. |  .||.| | ||||||| .  ....|.. .|  .   ||| | 
Ltklvelgrkcaqywpeegg....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpv

VVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCG
.||||||||||||||....||.... | ...... . ..| ||   ||| .||..... |.......
lVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0045450 (Phosphotyrosine protein) phosphatases II 1966-2121 1.4e-42 141.9 In-house 145-304 (307) alignment 
Range on Protein: 1966-2121
Range on HMM: 145-304/307.0
DSNKCAQYWPEKvNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKD-DDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP--PKGPPLVVHCS
...|||||||.. .|.   .. . .... ||..  || |.| .|    ...|  .||.. | ||||||| .   ...||. .|  .   ||| | .||||
grekcaqywPde.geeltygn.ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

AGVGRTGTFIVIDTMLQRMKQENT---LNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
||||||||||....||.....|.|   ..... . ..| ||   ||. |||..... |....
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1961-2121 1.5e-41 137.3 In-house 122-279 (288) alignment 
Range on Protein: 1961-2121
Range on HMM: 122-279/288.0
TKI-TTDSNKCAQYWPEKVNEThKLDDGIIIRTKTEEVHCwYTKRQLLITKDDDsmSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
|..   . .|| .|||.. ... .  .  .. ....|..  ...|.||. |. .   . ||.|| ..||||||| .|  .. .....  ... .  |..|
telveggktkCeeYWPdadkpk.nyGsvtvtlveskeled.fvlrklllekkkt..eleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiiv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
|||||||||||||..|........|..... ... ..|.|| .||||..||..|.. |.. |
hCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1964-2196 4.2e-41 135.6 In-house 122-354 (515) alignment 
Range on Protein: 1964-2196
Range on HMM: 122-354/515.0
TTDSNKCAQYWPEKVNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDsmSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSA
  |  ||..|||.|  .. |.   | . . . |     .||.| ..|.||  | ..| ...| |||.||| .   .. .| ...  |     ||..||||
egdkikcgkyWPdkpgdsvkfGs.ikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsa

GVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKNED-EECEFQKEFELLKELS
|||||| .| || .. ..|. .......|. .|| .|  ||||.||| .|.  . ...   .|   . .    ...|    .      . |||. || | 
GvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslc

DT--TSTISCSIAMDNQERNRFDYNLPYNHTRVILR
    .|   .. . ||. .||.  ||| .. |||| 
pdppasqtrsgrtrdnhpknrygnnlplqrnrvild
subfamily_Ptp69D_pd Subfamily Ptp69D 1952-2140 1.1e-40 134.7 In-house 114-305 (307) alignment 
Range on Protein: 1952-2140
Range on HMM: 114-305/307.0
EAVELYSYITKITTDSN-KCAQYWPEKvnETHKLDdGIIIRTKTEEVHCWYTKRQLLITKDDDSM-----SMAITHYQLTVWPDHGVPVDKIVMISFIDN
  |.|   ....|  .. |||.|||.   .. . .  |....  || |  |..|.| ..| ...      |  .. |. | |.|  ||     .. .|..
qevtlivmlsnlteknrkkcakYWpie..devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieq

IRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKEL
.|  .  .  |.||||||||||.|.|. .| .||..|.|....|...  ..|.||  |||  |||......|.|... |.|  .... . .|..|
vrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1960-2122 1.1e-40 134.5 In-house 115-277 (281) alignment 
Range on Protein: 1960-2122
Range on HMM: 115-277/281.0
IT-KITTDSNKCAQYWPEKVNeTHKLDDgIIIRTKTEEVHCWYTKRQLLItKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNI-RLTHPPKGPPL
.| .| ..  || .|||.. . . |. | .......|| .  | .|.. . . ... .  ... . | ||||||| .   ...| ... .||.. .  ||
vtreieagklkChrYWPddns.elkygd.vtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkapl

VVHCSAGVGRTGTFIVIDTMLQRMKQE-NTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQ
|.|||||||||||.| .|........| ..|.. . . ..|..|  .|||  || ...| . | ..
vihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0045098 (Phosphotyrosine protein) phosphatases II 1965-2125 2.5e-40 134.0 In-house 101-276 (278) alignment 
Range on Protein: 1965-2125
Range on HMM: 101-276/278.0
TDSNKCAQYWPEkvnETHKLDDGIIIRTKTEEVHCWYTKRQLLITKD----DDSMSMAITHYQLTVWPDHGVPVDK--IVMISFIDNIRLTHP-------
 . .||||||||   . ..  ... .... |||.  ||.| ||.|       | .|. .||.... ||||||| .     ...... ||  .        
lgrekcaqywpe...ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

------PKGPPLVVHCSAGVGRTGTFIVIDTMLQRMkqENTLNIYDFLLQIRHQRIT-LVQTKEQYIYIHKSLADHIQCGE
      ..| | .||||||||||||......||...  |....... . ..| ||    ||..|||..... |......|.
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
0042113 (Phosphotyrosine protein) phosphatases II 1966-2119 3.1e-40 133.5 In-house 90-241 (245) alignment 
Range on Protein: 1966-2119
Range on HMM: 90-241/245.0
DSNKCAQYWPEkvNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP-PKGPPLVVHCSAG
. .|||||||.  .|. . .| .......||.. .|| |.| .|.. |. |  ..||. . ||||||| .   ...|.. .|     ... |..||||||
grvkcaqywpl..gesltygd.ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaG

VGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLAD
||||||||....||.... | ...... . ..| ||   ||| .||..... |..
vgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0040439 (Phosphotyrosine protein) phosphatases II 1966-2121 4.2e-40 133.3 In-house 92-246 (249) alignment 
Range on Protein: 1966-2121
Range on HMM: 92-246/249.0
DSNKCAQYWPEkvnETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP--PKGPPLVVHCSA
. .|||||||.   ....  ... .... .||. .|| |.| .|.  |. |  ..|.| | ||||||| .   ...||. .|  .   ||| |..|||||
grekcaqywpl...ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsa

GVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
|||||||||....||.... |....... . ..|.||   ||. |||..... |....
GvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 1963-2122 1.1e-39 131.0 In-house 118-278 (290) alignment 
Range on Protein: 1963-2122
Range on HMM: 118-278/290.0
ITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSmaITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCS
.  . .||..||||...|. . ..  .  .. . |.  .. |.| ......| .  .. .. | |||||||  .  ....|...| ..  .  |||||||
velgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrk..vyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCs

AGVGRTGTFIVIDTMLQRMKQENT---LNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQ
|||||||| |.|| . . .|.|..   |...| .|..|.|| .|||||||| ...|..|. .|
aGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2150-2401 3.8e-39 129.4 In-house 20-276 (315) alignment 
Range on Protein: 2150-2401
Range on HMM: 20-276/315.0
EFQKEFELLKELSDttSTISCSIAMDNQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVL
 | .||  | .     .    .   .|...||.. .||....||.|     . ..|||||| ...... . .| .| ||. .  ||| |. |.. . ||.
lfseefhdlpdPdi..yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivm

LHPVGT-DE--IPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLeLKFKNESAHNVTLYYYKKWNINTNNKPYLkPLFGILA--KNQLENGNRPIVV
.      |     |.|| . ... ..  . ||    .   |  .  |    | |. ..|| . ...|  .  .|     |. ..   | . .. . ...|
vtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts.sllklikevkadngkkefsllv

ACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
 |  ||| .| .... . ....| . . |.|.|... |..|| ||   |.| . .. . |.
hcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_PTPN12_pd Subfamily PTPN12 2144-2408 4.6e-39 129.0 In-house 3-283 (290) alignment 
Range on Protein: 2144-2408
Range on HMM: 3-283/290.0
NEDEECEFQKEFELLKELSDT-----TSTISCSIAMDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTM
... | ||.|||. ||.||.      . . ... .. |...||.   |||...|| |. .    ..|||||....| .    .| .| || .| .||| |
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

IHQQNCSVIVLLH---PVGTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEEN-DYQIITLELKFKNESaHNVTLYYYKKWNINTNNKpYLKPLFGIL--AK
| ..| ...|..     .|     ..|| ..... ......|. . ||  . |. | ||......|| ..|. . |..|      .   |.|. ..  ..
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkes.rkvyqfhYtaWPDhgvPs.saksllelielvr

NQLENGNRPIVVACNDGVGCSGTFLT---AYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGMLQH
.  |. . |.|| |  |||  || ..   ....... |..   |.|. ... | ||. ||   |.| . .. . |. .  |. 
elqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkelei
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2172-2400 1e-38 128.1 In-house 45-277 (315) alignment 
Range on Protein: 2172-2400
Range on HMM: 45-277/315.0
IAMDNQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPPQmgq
  . |...||.   ..|...|| |     | . ||.||....||.  . .| .| |. ..  ||| ........ ||.|  .  .|     ..|| .   
kkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...

AKKYQDLTVEHSLEKEENDYQIITLELKFKNEsAHNVTLYYYKKWNiNTNNKPYLKPLFGIL--AKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERA
   |  .|| .  |. ...| . ||   |...  ..|  . |  |  ...   |  ||  .   .|   .|   .||| |..||| .|||.|  . ...|
kviyGkitvtrkseevnteytvrtlsvvfgdn.irevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqa

KTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
..| . |...||.. |..| ..|. .|.| . .. | |
eaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2054-2141 1.3e-38 127.5 In-house 192-267 (267) alignment 
Range on Protein: 2054-2141
Range on HMM: 192-267/267.0
GPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHiqcgetsfaiekAQYRIKELR
..||||.||.||||.|||.|||..|.|.|.|....|.|||..||.|||.||.|||.|||||..||..            |..|.||..
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey............aegrlkeee
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1961-2123 1.6e-38 127.4 In-house 84-244 (250) alignment 
Range on Protein: 1961-2123
Range on HMM: 84-244/250.0
TKITTDSNKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPP-KGPPLVV
|...   ... |||| .. |..    .. .  . .|..  ||||.| ..|   . .  . ... .|||| |||     .. ...... ...  .  |..|
tnLkesektyhqywPvekaeky...GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPviv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQC
.|||||||.|.||.||..|.|.|.|......... ..|..|.  |...|||..... .   ...
qCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN6_pd Subfamily PTPN6 1965-2123 1.6e-38 127.4 In-house 135-299 (306) alignment 
Range on Protein: 1965-2123
Range on HMM: 135-299/306.0
TDSNKCAQYWPEKVNETHklDDGIIIRTKTEEVHCWYTKRQLLIT-KDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPP----KGPPLVV
   .|||.|||.. ....     | ... .|. .  |. |.|... |.... .  . .|. ..||||||| |. ....|.....  .      .  |.||
rgkekCarYWPdeeekee..yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivv

HCSAGVGRTGTFIVIDTMLQRMKQEN---TLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQC
|||||.||||||||||..|. ....     ..|...  ..|.||  ||||..|| ...|... .|. 
hCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2174-2404 2.5e-38 126.7 In-house 26-270 (274) alignment 
Range on Protein: 2174-2404
Range on HMM: 26-270/274.0
MDNQERNRFDYNLPYNHTRVILR-----DTENDYINASWVEGYKT-GNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPPQMGQ
. .|..||.   || ...||.|.     | . .|||| .. ||..  . .. || ||.|| .||| ||.|....|||.|  .   .     ...| . . 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

--AKKYQDLTVEHSLEKEENDYQIITLELKFKNEsAHNVTLYYYKKWNIN---TNNKPYLKPLFGILAKNQLENGN-RPIVVACNDGVGCSGTFLTAYSQ
  ...|.|. .. .  .|.|||.. .| ||  ..  ..|. |.| .|  .    . .. |. .  .  ... || .  |.|| |  |.|  | |...   
eiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

IERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEG
. . . |.| |... . . | .| |.|.  |.| . |. ||.|.. 
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPN13_pd Subfamily PTPN13 1966-2117 2.6e-38 126.9 In-house 115-265 (273) alignment 
Range on Protein: 1966-2117
Range on HMM: 115-265/273.0
DSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPpKGPPLVVHCSAGV
.  || .||||. |.. |. . . ..    . .  .. |.| ... . . |  ..| ... |||||||     .. |. ..|  .  .  |.|||||||.
gkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGi

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSL
||.||.|.||..|. ..... ... . . ..|.|| ..||||.|||...|..
GrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_PTPRK_pd Subfamily PTPRK 1960-2140 4.1e-38 125.9 In-house 117-296 (314) alignment 
Range on Protein: 1960-2140
Range on HMM: 117-296/314.0
ITKITTDS-NKCAQYWPEKVNEtHKLddgIIIRTKTEEVHCWYTKRQLLITK--DDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPP
.|...  .  || .||||. .  ..    | .     |... . .| . ..|     .    . ..| . ||||.||| .  ..... ..  .....  .
ltelvevgrvkClkyWPedtev.ygd...ikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGr

LVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKEL
.||||||| |||||||.||..|. ...|......    ..| ... .|.|.|||..|.  . .   ||||.  . . .   .| 
ivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyles
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2139-2403 1.3e-37 124.4 In-house 5-277 (281) alignment 
Range on Protein: 2139-2403
Range on HMM: 5-277/281.0
ELRKKNEDEECEFQKEFELLKELsDTTSTISCSIAMDNQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTM
.|........  |..|.| |... .. .| . | | .|...||.     |..||| .    .....|||||..|.|||  . .|.|| |. .. ..|| |
hlkqlsqndnaGfieeyeklaai.gvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IHQQNCSVIVLL-HPVGTDEI--PQFWPpQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESAHNVTLYYYKKWN---INTNNKPYLKpLFGILAK
. .|. |.||.. . . .. .   ..|| .  .. || |.||..  |.|.. |   ...|. ..  . .|.   |..|    . .. |  |.     . |
vweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkelle.frkevlk

NQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTE-GVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 . .. . |.|. |  ||| .||...    ......|    |. . ... | .|  .|  . .| . .  . .. .
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1964-2126 2.1e-37 124.2 In-house 136-296 (319) alignment 
Range on Protein: 1964-2126
Range on HMM: 136-296/319.0
TtdSNKCAQYWPEKVNETHKLDD-GIIIRTKTEEvhcwYTKRQLLITKDDDS-MSMAITHYQLTVWPDHGVPVDKIVMISFIDNIR-LTHPPKGP-PLVV
|   .||.|||| |......  .  .   ..|.|    |. |.. ...|        || . .  |||.|||   . .. .....| ||.  ... ..||
t..kdkcsqywplkivikeerfkvkvdsveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGET
||||||||||..||.|..|.|||.|. ...|.|. ..| || ||||   || .|. .| ..   | .
hcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1964-2144 2.4e-37 124.0 In-house 100-278 (284) alignment 
Range on Protein: 1964-2144
Range on HMM: 100-278/284.0
TtdSNKCAQYWPEKVNETHKLDD-GIIIRTKTEEvhcwYTKRQLLITKDDDS-MSMAITHYQLTVWPDHGVPVDKIVMISFIDNIR-LTHPPKGP-PLVV
|   .||.|||| |......  .  .   ...||    |. |.. ...|        |. . .  |||.|||   . .. .....| ||.  ... ..||
t..kdkcsqywplkivikeerfkvkvdsveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKN
||||||||||..||.|..|.|||.|. ...|.|. ..| || ||||   || .|. .| ..   | .  |.      ..|| .| 
hcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnks
subfamily_PTPN3_pd Subfamily PTPN3 1961-2116 3e-37 123.1 In-house 116-270 (280) alignment 
Range on Protein: 1961-2116
Range on HMM: 116-270/280.0
T-KITTDSNKCAQYWPEkVNETHKLDdGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
|  .     || |||||  ... ..  .. .. . |. .  |  |.|.... . . .  |.. | . ||||||| |.  ...|....| ..  |  |.||
ttlverGrvkChqyWPe.tedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKS
|||||.|||| .|...| |. . ... ... | . ..| || .||||..|| .. ..
hCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2158-2402 3e-37 123.3 In-house 30-284 (297) alignment 
Range on Protein: 2158-2402
Range on HMM: 30-284/297.0
LKELSDTTSTISCSIAMDNQ---ERNRFDYNLPYNHTRVILRDTEND----YINASWVEGYKTgnWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV-
 . |   ...|  .   ...   |..|.   |||.  ||.|. ...|    |.|||.|.|.|    .| || | ..|  |||.|. ... |.||.|    
eeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddn

-GTDEIPQFWPPQmGqAKKYQDLTVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYKKWNINTNNK----PYLKPLFGILAKNQLENGNRPIVVACN
 ....  ..|. . |  ... |..|. .  .| . .   .||..  .  . . |  | . .|  .. ..    ..|  |   . |.  .| . |..| | 
erdkkcaryWsdk.g.vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhcl

DGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
 |||  | .||  | . .|| |   |||....| | .|| ||   | | . .... |. 
aGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
0037934 (Phosphotyrosine protein) phosphatases II 1966-2118 6.7e-37 122.7 In-house 86-239 (243) alignment 
Range on Protein: 1966-2118
Range on HMM: 86-239/243.0
DSNKCAQYWPekvNEThkLDDGIIIRTKTEEVHCWYTKRQLLITKDD-DSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLT--------HPPKGPP
. .|||||||   .|.    ........ ||..  || | ||..  | |  .  ..||. . ||||||| .   ...|.| .|          . ..| |
grekcaqywp...gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggp

LVVHCSAGVGRTGTFIVIDTMLQRMkqenTLNIYDFLLQIRHQRIT-LVQTKEQYIYIHKSLA
..||||||||||||.|....||...    ...... . ..| ||    ||| .||..... |.
vlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1963-2131 1.5e-36 120.9 In-house 127-289 (315) alignment 
Range on Protein: 1963-2131
Range on HMM: 127-289/315.0
ITTDSNKCAQYWPEKvnethK-LDDGIIIRTKTEEVHCWYTKRQLLITKDDDSmsMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHC
.  . .|. .|||.|     | .   | .  | |||.  || | | .. .|.     .  ...| ||| |||   | .. .| ...  |  .  ..||||
vegekrkaekywpdk.....kviyGkitvtrkseevnteytvrtlsvvfgdni..revvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhc

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIE
||||||||||| .|..|.... || ...|.|. ..|..|| .||. ||| .|.. | . . ||.|| | .
saGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2176-2401 1.6e-36 120.5 In-house 43-275 (515) alignment 
Range on Protein: 2176-2401
Range on HMM: 43-275/515.0
NQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVG-TDEI--PQFWPPQMGQAKKY
| ..||.  .|||. .||.|     . ..||.||| ...... . .| .| |.. .  ||| .. |.| . |...      | |   ..|| . |.. |.
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

QDLTVEHSLEKEENDYQIITLELkFKNESAHNVTLYYYKKWNINTNNKPyLKPLFGILA--KNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEG
  . ||    .   .  . .|..  |.. .. || . ...|  .  .|   . |. ..   | . .. . |... |  |||  | .... | . .|||  
Gsikvelvsleactggikrkltv.lkgddsrtvtqfhfteWPdkGvpkh.tssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttr

VSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
. |.|.|... | .|| ||   |.| . .. . |.
mvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_PTPN9_pd Subfamily PTPN9 1961-2120 1.7e-36 120.8 In-house 117-289 (297) alignment 
Range on Protein: 1961-2120
Range on HMM: 117-289/297.0
TKIT-TDSNKCAQYWPEKVNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRL-----------
|..  .   ||.||||.. .....  | . ...   |..  |..|.| |.. ... |  .||.|.. |||.||| .   .. .....|            
trvvergrlkcgqyWpleeessaefgd.lsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgd

--THPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
  . .|.|||.|||||||.||||||| .|  |.|.....|... . . ..| ||   .|| ||| . .... ..
ewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1966-2122 7.6e-35 115.2 In-house 102-265 (270) alignment 
Range on Protein: 1966-2122
Range on HMM: 102-265/270.0
DSNKCAQYWPEKVNETHKLDDGII-IRTKTEEVHCWYTKRQLLITkdDDSMSMAITHYQLTVWPDHGVPVDKI------VMISFIDNIRLTHPP--KGPP
  .||..|||....|. || || | ... .|| .  | ...| ..  ... .  ..|.. . ||||||| ..        ... . ..| ..    |. |
grkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaeP

LVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQ
|.||||||||||||.|..|.... ..... ...   . ..|..|. |||. ||| ...|... ...
llvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1961-2142 9.9e-35 114.9 In-house 119-298 (315) alignment 
Range on Protein: 1961-2142
Range on HMM: 119-298/315.0
TKIT-TDSNKCAQYWPEKVNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDsmSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
||    |  ||.||||..  .. ..   | . .   |     ..|.| . | ..  |  .| .|.| |||.||. .   .. .| ...  . .|  .|.|
tkkqegdkikcrqywPdrkadsvefGs.ikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRK
|||||||||| .| || .....|.........|. ..| .|. ||||.|.| .|. .. ....  .|   . .   ....|. 
hcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlht
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1957-2053 2.2e-34 113.7 In-house 12-118 (267) alignment 
Range on Protein: 1957-2053
Range on HMM: 12-118/267.0
YSYITKITTDSNKCAQYWPEKVNETHKLDDG-------IIIRTKTEE------VHCWYTKRQLLITKddDSMSMAITHYqLTVWPDHGVPVDKIVMISFI
.  |.||...|....|...||..|...|||.       .|.|||.||      |....||.....|.  |.....||.. |||..|..|||.......|.
felikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtq..dplkntitdf.ltvihdqkvpvivlltkvft

DNIRLTHPPK
|||||..|||
dnirlfwPPk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1962-2124 7.5e-34 111.9 In-house 124-286 (290) alignment 
Range on Protein: 1962-2124
Range on HMM: 124-286/290.0
K-ITTDSNKCAQYWPEKvnETHKlDDGIIIRTKTEEVHCWYTKRQLLITKDDD-SMSMAITHYQLTVWPDHG-VPVDKIVMISFIDNIRLTHPPKGPPLV
. |  ...|| ||||..  .|..  . . |.   ||..  |..|.| .....    .  .|.||.| |...| |.  . .....   ..  . .   ..|
niieegkvkCqqYWpds..dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsiv

VHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCG
||||..|||...|....| ....|.|   .... | . | |.  .|||..|| .|.. .   ... 
vHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2147-2401 8.7e-34 111.6 In-house 13-292 (301) alignment 
Range on Protein: 2147-2401
Range on HMM: 13-292/301.0
EECEFQKEFELLKELSDTTSTISCSiaMDNQERNRFDYNLPYNHTRVILRDTEN------DYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNC
.. .|..... ||| .| ..|...|   .|.. |||  . .|.. |.||. ..|      .|||||...||.  . ||..| |...| .||| .| |.  
hsnkfeeqykelkegedksctvgls..eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

SVIVLLHPVGT---DEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNES----------------AHNVTLYYYKKWNINT---NNKPY
. || .        ..  |.||    . ...  .||. . |.   |. |  | .| .. |                ...|. .   .|  .    . .  
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LKPLFGILAKnQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
|. .  .. . |   |  |.|| | |.|. ||.. .    .| .| ||| |.|| ..  | ..|| |  || |.  .. . .|
Lqviddvihr.qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_PTPN13_pd Subfamily PTPN13 2152-2398 1e-33 111.8 In-house 14-265 (273) alignment 
Range on Protein: 2152-2398
Range on HMM: 14-265/273.0
QKEFELLKELSDTTSTiSCSIAMDNQERNRFDYNLPYNHTRVILRDTENdYINASWVEGYKTGN--WFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLH-P
..||. |.||  . .. . .   .|...||.   |||..|||.| |  . |||||...     .   .|..| || .| .||| |. .|...||...   
aeefkelrelkpldtc.evgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

VGTDEI--PQFWPPQMGQAKKYQD-LTVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLENGNRPIVVACND
. ....   ..|| ....  | .. |.||    .. ..... .|..| .. . ...|.   . ||      .  .. |  .   ..|.. . |||| |  
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsa

GVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELL
|.| |||..| .  ..  . .   |. . .|| | || |.|   ..||.... .
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_PTPN1_pd Subfamily PTPN1 2159-2391 1.5e-33 110.8 In-house 13-260 (290) alignment 
Range on Protein: 2159-2391
Range on HMM: 13-260/290.0
KELSDTTSTISCSI--AMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVG---TDE
..... .| ....      |...||.    ||.|.|..|....||||||| ||  .    .|.|| || || . || |. .|..  .|.|  |    .  
ldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

IPQFWPPQMG-QAKKYQ--DLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWN---INTNNKPYLKPLFGILAKNQLENGNRPIVVACNDGV
  |.|| .   .. ...   |.|.   |.... |.. .|||.  | . ..... ..| .|.   .      .|| || .     | .   | |. |  |.
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GCSGTFL---TAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERY
| ||||    |   .||. .     || . . ..|..| ||.   .. 
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadql
subfamily_PTPN3_pd Subfamily PTPN3 2165-2401 4.5e-33 109.4 In-house 30-275 (280) alignment 
Range on Protein: 2165-2401
Range on HMM: 30-275/280.0
TSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVE----GYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV---GTDEIPQF
  .||..   .| ..||.   |||..|||.|...|.|||||..|.    . .. | .|.|| ||..| ||||.|...|..|.||.|  .   |     |.
glaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPPqMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYKKWN---INTNNKPYLKPLFGIlaKNQLENGNRPIVVACNDGVGCSGTFL
||  ...  .| ...|. . |.|.. | .  | || |. .  ....   |  |    . .... .|. .  .  ... .  ..|.|| |  |.| .| ..
WPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv..rklrsgkeePvvvhCsaGigrtGvli

TAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE-Y
.    .    ..    . . .|. | ||  ||.  ..| .  | ... |
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1958-2122 5e-33 109.3 In-house 102-269 (274) alignment 
Range on Protein: 1958-2122
Range on HMM: 102-269/274.0
SYITKITTDSN-KCAQYWPEKVNE-THKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDsmSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPK--
  .||..   . |||.|.|.. .   ..  ... |...    .  |. |.|.. .  .  .  ..||  | |||| .| |   ......... ..  .  
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeena

-GPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQ
   | |||||||.|||| || |.  ......|.....     ..| .|  .|||.||| .||. |. . .
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1963-2117 6.3e-33 109.0 In-house 80-235 (237) alignment 
Range on Protein: 1963-2117
Range on HMM: 80-235/237.0
ITTDSNKCAQYWPEKvNETHKLdDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMA-ITHYQLTVWPDHGVPVDKIVMISFIDNI--RLTHPPKGPPLVV
|  .  || .|||.  ..       . .  | .|  . || | ||..|      .  |  ||.|.|||.|||     .. |  ||  |  | ..  | ..
iegnelkchkywpst.dqpaay.gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwii

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSL
|||||||||| |.|||.||.. |... ..||...  |  .|  ..|||.||..||...
hcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
PTPc_DSPc_SM00012 2019-2118 9.4e-33 107.9 In-house 2-104 (105) alignment 
Range on Protein: 2019-2118
Range on HMM: 2-104/105.0
ITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPK--GPPLVVHCSAGVGRTGTFIVIDTMLQRMKQE-NTLNIYDFLLQIRHQRITLVQTKEQYIYIHK
..||. | ||||||| .   .........  .  .  ..|.||||||||||||||...|..||....| ....|.... ..|.|| ..|||.|||.....
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

SLA
 |.
all
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1959-2128 4.1e-32 106.5 In-house 122-291 (297) alignment 
Range on Protein: 1959-2128
Range on HMM: 122-291/297.0
YITKITTDSNKCAQYWPEKVNEThklDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPV--DKIVMISFIDNIRLTHPPKGP-
 ...     .|||.||..|   |      . . ... .  . . ||.| .||..  .   .  || . |||. |.   .   .. .|...| ..  .   
mlnddnerdkkcaryWsdkgvtt...fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg

PLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSF
||.|||.||||||| .. || .. ..|.|....|.... ..|..|  |||||||| .... . . . . .|  
PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtri
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2173-2405 4.9e-32 106.0 In-house 17-267 (270) alignment 
Range on Protein: 2173-2405
Range on HMM: 17-267/270.0
AMDNQERNRFDYNLPYNHTRVILRDTEN----DYINASWVEGYKTG-NWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHP---VGTDEIPQFWPPQMGQ
|  ... ||.   ||  .|||.| . |.     |||| .|.|..   . .| .. ||..| ..|| || ... . ||.. .    |...  ..||.. ..
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

AKKYQDLTVEH--SLEKEENDYQIITLELKfKNESAHNVTLYYYKKWN-----INTNNKPYLKPLFGILAKN-----QLENGNrPIVVACNDGVGCSGTF
  |..| ...   . |. |. | .  |.|. .. . .... ..|..|.      ..... . . |  .|..      .|.... |..| | .||| .||.
kvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtl

LTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGM
..    ..  ....  |. . |.. | .|. ||.  |.| . .. . |||| .
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1964-2127 1.2e-31 104.7 In-house 122-284 (287) alignment 
Range on Protein: 1964-2127
Range on HMM: 122-284/287.0
TTDSNKCAQYWPEKVNetHKLDDgIIIRTKTEEVHCWYTKRQLLITKDD-DSMSMAITHYQLTVWPDHG-VPVDKIVMISFIDNIRLTHPPKGPPLVVHC
 .| ..| |||||. .    | .   |.   |||.  |..|.| ..... ..    .. ||.| |...| |.  . ... . . ..  . .   ..||||
endeevcyqyWpeeks..vvlGe.yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhC

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETS
|..|||...|. ..| ... |.| ...... | . | |. . ||| |||..| . .  .....|| 
sdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1963-2116 2.5e-31 103.7 In-house 86-235 (239) alignment 
Range on Protein: 1963-2116
Range on HMM: 86-235/239.0
ITTDSNKCAQYWPEKVNETHKLDdgiIIRTKTeEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCS
|    .|| ||||.  ..  .|    .   || || . |  | .....  ..    . .|..|||||.|||     .. .  .|     |   | |.|||
ieghkkkchqywpdstskycnlr...vtlrkt.evfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcs

AGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKS
|||||||.|.|||.||.. |...|..|....  || .|  .||| |||..|| .
agvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1963-2116 2.7e-31 103.6 In-house 87-236 (239) alignment 
Range on Protein: 1963-2116
Range on HMM: 87-236/239.0
ITTDSNKCAQYWPEKVNETHKLDdgiIIRTKTeEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCS
|    .|| ||||.  ..  .|    .   || || . |  | .....  ..    . .|..|||||.|||     .. .  .|     |   | |.|||
ieghkkkchqywpdstskycnlr...vtlrkt.evfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcs

AGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKS
|||||||.|.|||.||.. |...|..|....  || .|  .||| |||..|| .
agvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_PTPN1_pd Subfamily PTPN1 1964-2123 4.7e-31 102.6 In-house 107-273 (290) alignment 
Range on Protein: 1964-2123
Range on HMM: 107-273/290.0
TTDSNKCAQYWPEKVN-ETHKLD-DGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTH--PPKGPPLVV
  ...|||||||.. . .. .|.   . ..  .||..  || |.| ...     .  |.|.  | ||| |||     ...|. ..| .    ..  | |.
ekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavi

HCSAGVGRTGTFIVIDTMLQRMKQEN---TLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQC
|||||.||.|||...||.| ......   ...| . ||..|..|. |.||..|  . . .. . ...
hcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1964-2144 2e-30 101.0 In-house 126-311 (325) alignment 
Range on Protein: 1964-2144
Range on HMM: 126-311/325.0
TTDSNKCAQYWPEKVNETHKLdDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRL-----THPP-KGPPL
 .. ..||.|||... .. ..  |. .. .| |    | .|.| . . ..  ....  .||  |.| ||.     .||... .       |       |.
dlgkdrcavywpkemgksktf.GglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpi

VVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKN
.|||||||||||.|| . ..|... .|  ..|..|. ..|..| ..|.| .||| |...|.. . .|.|   .   . ..  |...|
lvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqern
0036282 (Phosphotyrosine protein) phosphatases II 1960-2115 1e-29 98.9 In-house 44-164 (174) alignment 
Range on Protein: 1960-2115
Range on HMM: 44-164/174.0
ITKITTDSNKCAQYWPEkvnethklddgiiirtkteevhcwytkrqllitkDDDSMSMAITHYQLTVWPDHGVPVDKIvMISFIDNIRLTHPP-KGPPLV
.. .  .. || .||||                                  . ....  . .|. . ||||||| . | ...|.. ..  .   .| |..
leekelglykcinywpe..................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHCSAGVGRTGTFIVIDTMLQRMKqENTLNIYDFLLQIRHQRITLVQTKEQYIYIHK
||||||||||||..... ||.... |.. ...|.. ..| ||   ||| .||.....
VHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2138-2402 2.7e-29 96.9 In-house 4-277 (287) alignment 
Range on Protein: 2138-2402
Range on HMM: 4-277/287.0
KELRKKNedeecEFQKEFELLKELSdTTSTI--SCSIAMDNQERNRFDYNLPYNHTRVILRDTE---NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFW
.|.| |.     . .||.. ||| |  .||.    .  . . ..||.   ||...|||.|  .     ||||| .| .|.  . ||..| |.  |  |||
eerrvkd.....dvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfw

TMIHQQNCSVIVLL-HPV--GTDEIPQFWPPQmGQAKKYQDLTV-EHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWnINTNNKPY----LKPLF
... ... ...... . |  .  .. ..|| .  .  .    .|   . .. | .| . .| |   . . |. |  . . .|  .    |     ..  .
ravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllsw.PdkvlaPtavglirfvl

GI---LAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
 .   .  ..  ..  |.|| .. |.| ||..|. .  ..| .  |  |. . . . | .| .|| .  .. .  | |  | 
dvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_PTPN14_pd Subfamily PTPN14 2136-2401 3.6e-29 96.7 In-house 12-295 (300) alignment 
Range on Protein: 2136-2401
Range on HMM: 12-295/300.0
RIKELRKKNEdeECEFQKEFELLKELSDtTSTISCSIAMDNQERNRFDYNLPYNHTRVIL---RDTENDYINASWVEGYKTGN--WFIVTQIPLQNTQTD
|.| | || |  | .  .|.| ... .   ...|..   .|.|.|||   |||...|| |   ......||||| ..   .|.   .||.| ||..| .|
rakilekkle..egkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqd

FWTMIHQQNCSVIVLLHPV---GTDEIPQFWPPQ--MGQAKKYQDLTVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYKKW---NINTNNKPYLKP
|| |. .|. ..||.|      | .   ...| .    .  ...   |   . .. . .  ..|.||.   .   .|    |. |   ..  . |..|. 
fWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsy

LFGI---LAKNQ--L--ENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
|  .     | .     .. . |..| | .||| .|  ...   |.  ... . || . ... | ||  ||. | .| . ...| .|
LeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
0051429 (Phosphotyrosine protein) phosphatases II 1966-2120 5.3e-29 97.1 In-house 59-224 (272) alignment 
Range on Protein: 1966-2120
Range on HMM: 59-224/272.0
DSNKCAQYWP---------EKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKD-DDSMSMAITHYQLTVWPDHGVPVDKivMISFIDNIRLthppkGP
...|| .|||         .   ..  |   . ...  ||..  |. | ||.|.  . .... ..|.. | ||||||| .   ...... ..      | 
grlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....gg

PLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLN--------IYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
|..||||||..||||..... .|...  |  ..        ..... ..| ||   ||| |||..... |.. 
pvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2175-2398 6.1e-29 95.9 In-house 2-235 (237) alignment 
Range on Protein: 2175-2398
Range on HMM: 2-235/237.0
DNQERNRFDYNLPYNHTRVILRDT--ENDYINASWVEGYK-TGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVG---TDEIPQFWPpQMGQAKKY
.|. .||.     |.|.||.|. .  . |||||....|.  | . .| .| ||...  ||| |. |..|||||.|  .         ..|| .  | . |
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaay

QDLTVEHSLEKEENDYQIITLELKFKNESA--HNVTLYYYKKWNI---NTNNKPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAK
  |||    ..|  || . .| |  . .      .  | .  |       .    |.    |. ...  .   | .. |. ||| .| ||   . . .||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

TEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELL
 . | ||....     .|| ...  ..|.. |. .
ekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2149-2395 3.3e-28 93.2 In-house 20-229 (392) alignment 
Range on Protein: 2149-2395
Range on HMM: 20-229/392.0
CEFQKEFELLKELSDTTSTisCSIAMDNQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIV
. | .||  | .      |  ..   .|...||.. .|||. .||.|      ...||.|||....... . .| .| |   .  ||| |..|.| . |.
alffeefhdlpgpdiypqt..vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttia

LLHPVGTDEipqfwppqmgqakkyqdltvehslekeendyqiitlelkfKNESAHNVTLYYYKKWNINTNNKpYLKPLFGILAKNQLENG--NRPIVVAC
..  .   .                                        | ..|. |. ... .|  .   | .   |. .. . . . |   .|... |
mvtklkegd........................................kgddartvaqfhftewPdkdvpk.htssllkfikevkadfGqythpliihc

NDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCH
. ||| .|  ..  | . .||.  . |.|.|. . | .|| .|.  |.| . .
sagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiy
0051429 (Phosphotyrosine protein) phosphatases II 2200-2409 5.5e-28 93.8 In-house 4-232 (272) alignment 
Range on Protein: 2200-2409
Range on HMM: 4-232/272.0
NDYINASWVEGYkT----GNWFIVTQIPLQNTQTDFWTMiHQQNCSVIVLLHPVG---TDEIPQFWP----------PQMGQAKKYQDLTVEHSLEKEEN
..||||..| || .     . .. .. ||..|. |||.. .......|| | ..     .  ...||          . . .   | .|.| .  |.  .
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYQIITLELKFK--NESAHNVTLYYYKKWNINTNNKPYLKPLFGILAKnqlengNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSD--------IFQ
|| . .|.|...  .. |. |....|  |      . .|. |. .|..      ..|..| |. |.. .||.  ..  ...   | . |        ...
dyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

FIRKARSQRPGLVDCLERYIYCHELLCEYAEGMLQHE
.... |.|||| |   | |....| | |.....|. .
aveelraqrpgavqteeqylflyeallellrsllsvr
subfamily_PTPN14_pd Subfamily PTPN14 1951-2122 9.8e-28 92.0 In-house 115-297 (300) alignment 
Range on Protein: 1951-2122
Range on HMM: 115-297/300.0
EEAVELYSYITKIT-TDSNKCAQYWPEKVNETHKLDDG-IIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRL
|. |.|   .|...    .|. .|.|.. .. .... |   . ||  |    .. ..| .     .    . | | | ||||||| |   ..|...... 
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

---T----HP--PKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQ
         .   . ||..|||||||||||  |. | ... ........|   | ..|.|| .||||  || ...| |  ...
vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1960-2129 1.3e-27 91.4 In-house 106-274 (283) alignment 
Range on Protein: 1960-2129
Range on HMM: 106-274/283.0
ITKITTD-SNKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKD-DDSMSMAITHYQLTVWPDHG--VPVDKIVMISFIDNIRLTHppKGP
.||.  |   ||.||||..  | .       .  . |  .  .....||. ..     .. ..|||.  | . |   ... .| .  .   .  .  |  
ltklqedlrikCsqyWPkrGsedy...GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes..kkg

PLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFA
|.|||||.|.|||..|| . . .. .. |  ....  .  .| ||...|||..||  .|.   ..  ||.|  |
PivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
0041856 (Phosphotyrosine protein) phosphatases II 2176-2402 1.5e-27 91.8 In-house 1-171 (182) alignment 
Range on Protein: 2176-2402
Range on HMM: 1-171/182.0
NQERNRFDYNLPYNHTRvilrdtENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHpvgtdeIPQFWPpqmgqakkyqdltveh
|...||.   |||.|.|       .|||||... |.  .. ||.|| ||..|  ||..|........|| |        .. ||                
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp................

slekeendyqiitlelkfkneSAHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLenGNRPIVVACNDGVGCSGTFLTAYSQIERakteGvSDIFQFIR
                     .  . . . |.....  .. | |  |. .. . .    ..|..| |. ||| .||.  ||  ...    |  .... ..
.....................ellerlgiqylylpwpDhgvpdldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavk

KARSQRPGLVDCLERYIYCHELLCEYA
  ||.||| | ... |.... .|.|. 
lvrsrRpgmvitpnqyfflqlallell
subfamily_PTPN23_pd Subfamily PTPN23 1962-2113 1.7e-27 91.0 In-house 117-272 (288) alignment 
Range on Protein: 1962-2113
Range on HMM: 117-272/288.0
KITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHcWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRL----THPPKGPPL
|  .. .|...||||. .||.| .|  .   ...| .  . .|.| ..  | .    ..| ||| ||..|||    ... |.|...     .. .   ||
keelgkpkvdrYwPedkgetvkfgdlsvtlksvrete.thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPl

VVHCSAGVGRTGTFIVIDTMLQRMKQENTL-NIYDFLLQIRHQRITLVQTKEQYIYI
||||||||||||.| .. . .. ....| | .| . . ..|.||   ||.|||.   
vvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfs
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2142-2400 1.8e-27 90.9 In-house 13-277 (439) alignment 
Range on Protein: 2142-2400
Range on HMM: 13-277/439.0
KKNEDEECEFQKEFELLKELSDTTSTISCSIAMDN-QERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIH
| . ...  |...|| ..  |   . |.. .| .  | .||.    ...||||.|...       |||| ...|| . . .| ||.| ..|  ||| .. 
kldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvi

QQNCSVIVLLHPVGtdEIPQFWPPQmgQAKKYQDLTVEHSLEKEENDYQIITLELKFKN---ESAHNVTLYYYKKWN---INTNNkPYLKPL-FGILAKN
..... || |  .   |  ..|| .  .   | |..|    . |  .| |  . .  .    |  . |  ..|  |    . ..   ..  .   | . |
ekktvtivmltnlv..esykywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqa.shvldflrainsan

QlENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
. ..   |.|| |  ||| .|| ..    .|. |.|   ||   ..  | ||  .|. | .|.. .. . |
d.keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_PTPN9_pd Subfamily PTPN9 2149-2309 2e-27 91.0 In-house 16-183 (297) alignment 
Range on Protein: 2149-2309
Range on HMM: 16-183/297.0
CEFQKEFELLKELsDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIV
   .||.. ...   .. |. .|    | |.||.   | |..||| |     |.. |||||..|.|||  . || || ||..| .||| |. .|.. |||
rGlskeyaeirne.pveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

LLHP---VGTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELK-FKNESAHNVTLYYYKKW
.       |     |.||.. ...... ||.|..   .||.||.. .||.|  |.|   .|| . .  |
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsW
0049772 (Phosphotyrosine protein) phosphatases II 2173-2404 6.5e-26 87.2 In-house 43-282 (314) alignment 
Range on Protein: 2173-2404
Range on HMM: 43-282/314.0
AMDNQERNRFDYNLPYNhTRVILrDTEN----DYINASWVEGYktgNWFIVTQIPLQNTQTDF----------WTMI--HQQNCSVIVL-LHPVGTDE--
   |...||.   ||.. .|||| ....    ||||||.| |.   . ||.|| ||..|  ||          |.|.   ..|. .||   . |  ||  
lflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------IPQFWPPQmgqakkyqD---------LTvehslekeendyQIITLELKFKNESAHNVTLYYYKkWNINtnNKPYLKPLFGILAKNqleNG
          ........        .         |             ....   .|...  . . .  .  .. .     ... .. .. ..   . 
rLdaAlgKtpllildgng........neptaadlellk............eelydpelferlgikylripvpD.gsap..lledfdeflefieea...dk

NRPIVVACNDGVGCSGTFLTAYSQIERAKTeGVSDIFQFIRKARSQR--PGLVDCLERYIYCHELLCEYAEG
..|..| |..|.| .|||..|.  . . .   . ......|..|. .  ||..  ||.|....| |.|| . 
ggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
0043147 (Phosphotyrosine protein) phosphatases II 1990-2114 1.5e-25 85.3 In-house 54-154 (172) alignment 
Range on Protein: 1990-2114
Range on HMM: 54-154/172.0
IrtkteevhcwytkrqlliTKDDDSMSMAITHYQLTVWPDHGVPvDKIVMISFIDNIRL-THPPKGPPLVVHCSAGVGRTGTFIVIDTMLqrmkqeNTLN
                   ..| .  .  . .|. . ||||||| .  ....|.. |.   .  .| | .||||||||||||..... ||        |.
l..................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgls

IYDFLLQIRHQRITLVQTKEQYIYIH
... . ..|..|   ||...||....
leeavalvrekRpgavqnpsqyrfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1966-2119 1.9e-25 84.1 In-house 132-281 (290) alignment 
Range on Protein: 1966-2119
Range on HMM: 132-281/290.0
DSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppkGpPLVVHCSAGV
   ||.||.|||  |.  . .  .. .. ..      |. | . . |.  .  . |...  |||. |.  .. ..  .  .| .    | |.|||||||.
GkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkas...G.pvvvhcsaGi

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLAD
||||||. |.. || . .   |.. |    .|. |.. ||   ||. . . | |
GrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
0041856 (Phosphotyrosine protein) phosphatases II 1961-2125 2.8e-25 84.4 In-house 66-175 (182) alignment 
Range on Protein: 1961-2125
Range on HMM: 66-175/182.0
TkittdsnkCAQYWPEKVnethklddgiiirtkteevhcwytkrqllitkdddsmSMAITHYQLTVWPDHGVPVdKIVMISFIDNIRLthppKGPPLVVH
|        . .||||..                                       ....|. . |||||||     ...||. ..     .| | .||
t........eelywpell.....................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVH

CSAGVGRTGTFIVIDTMLQRmkqenTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGE
||||||||||..... |...      ..... . ..| .|   |.| .||....  | .......
CsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2176-2396 3.1e-25 83.7 In-house 7-234 (239) alignment 
Range on Protein: 2176-2396
Range on HMM: 7-234/239.0
NQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKTG-NWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVG---TDEIPQFWPPqmgQAKK
|. .||.   . |.|.||.|     |  .||||||..  |    . .| ||  .. .  ||| |. |.   |||.|  .      .  |.||     . |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...stsk

YQDLTVEHSLEKEENDYQIITLELKFKNE-SAHNVTLYYYKKWNINTnNKPYLKPLFGILAK---NQLeNGNRPIVVACNDGVGCSGTFLTAYSQIERAK
| .| |     .   || | |. .    .   . |  |..  |  .     |   ..|.  |   . |  | || |. |. ||| .|.||   . . .||
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkg.vpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidamlrqak

TEGVSDIFQFIRKARSQRPGLVDCLERYIYCHE
 .   |||....  | .|| .|.  |.|.. | 
kqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2147-2405 3.3e-25 83.1 In-house 24-288 (302) alignment 
Range on Protein: 2147-2405
Range on HMM: 24-288/302.0
EECEFQKEFELLKELSDTTSTisCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQ---TDFWTMIHQQNCSVI
.. | .|||. ....   .    |..  .| ..|. .    .....|.|  ....|.||| ||  . ..  |..|.| ....    .|| |..|...  .
dtaevkkefkkidtmkvdlek..CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsv

VLLhpVGTDEI----PQFWPPQMGQAKKYQDLTVEH-SLEKEENDYQIITLELKFKNESA-HNVTLYYYKKWN---INTNNKPYLKPLFGILAKNqlENG
|.|  ||..|.     ...| ..|. |.|... |     || |.. .  ..|.  .. |    ...|  . |.   . ..     |   .. ||.  ...
vil..vgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakk..ika

NRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGM
. ..|.. . |.|  |.|||.   .|. ...    | . ... |||||  || |. |.  .  |  |    
dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2176-2396 3.3e-25 83.6 In-house 8-235 (239) alignment 
Range on Protein: 2176-2396
Range on HMM: 8-235/239.0
NQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKTG-NWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVG---TDEIPQFWPPqmgQAKK
|. .||.   . |.|.||.|     |  .||||||..  |    . .| ||  .. .  ||| |. |.   |||.|  .      .  |.||     . |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...stsk

YQDLTVEHSLEKEENDYQIITLELKFKNE-SAHNVTLYYYKKWNINTnNKPYLKPLFGILAK---NQLeNGNRPIVVACNDGVGCSGTFLTAYSQIERAK
| .| |     .   || | |. .    .   . |  |..  |  .     |   ..|.  |   . |  | || |. |. ||| .|.||   . . .||
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkg.vpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidamlrqak

TEGVSDIFQFIRKARSQRPGLVDCLERYIYCHE
 .   |||....  | .|| .|.  |.|.. | 
kqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1962-2118 6.4e-25 82.4 In-house 130-286 (305) alignment 
Range on Protein: 1962-2118
Range on HMM: 130-286/305.0
KITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEeVHCWYTKRQLLITKDDDS----MSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPpkgpPL
 . .   |||||||    | ..|  ||..   .   .      .. ||  . .     .|.. | | | ||| |||  |.  . ..  || ..     |.
tvelgklkcaqywpaaqgeklelksgivvenvsg.skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv....pi

VVHCSAGVGRTGTFIVIDTMLQRMKQENT-LNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
|||||||.||||| . |. .|... ...    . ...  .| ||   .|.  ||..||. . 
vvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvml
0049260 (Phosphotyrosine protein) phosphatases II 1966-2114 6.9e-25 82.9 In-house 47-143 (152) alignment 
Range on Protein: 1966-2114
Range on HMM: 47-143/152.0
DSNKCAQYWpekvnethklddgiiirtkteevhcwytkrqllitkdddsmsmaitHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGV
.  ||.||.                                              .|. . ||||||| . .... ... |.     || | .|||||||
gklkceqyi..............................................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGv

GRTGTFIVIDTMLqrmkqeNTLNIYDFLLQIRHQRITLVQTKEQYIYIH
|||||..... ||      . ....... ..| .|   |....|.....
gRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0036282 (Phosphotyrosine protein) phosphatases II 2200-2396 9.3e-25 82.7 In-house 2-164 (174) alignment 
Range on Protein: 2200-2396
Range on HMM: 2-164/174.0
NDYINASWVEGYKTGNWFIVTQIPLQntqtdFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPPqmgqakkyqdltvehslekeendyqiitlelKFKNE
.||||||.. ..   . .|..| ||.     || |.........| | .   ..   ....||                                . . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SAHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKtEGVSDIFQFIRKARSQRPGLVDCLERYIYCHE
. ......|.     .. . . |  .. .. . ..|....|..| |. ||| .||.  ||  . . . |.. |.....|..|.|||| |   . |.....
erlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1965-2133 1e-24 81.8 In-house 126-291 (439) alignment 
Range on Protein: 1965-2133
Range on HMM: 126-291/439.0
TDSNKcaqYWPEKVNeTHKldDGIIIRTKTEEVHCWYTKRQLLITKDDD--SMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPK-GPPLVVHC
 .| |   ||| . . .      |..|.  .     |. | . . .. |      .. ... . |||. || .   .. |.  |  .   .   |.||||
vesyk...ywpsdae.vcy..gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhc

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKA
||||||||| | .|  |...| || ..|   .  .|.||  .||.  ||..|.... . |. |... .|.. 
sagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1966-2126 1.6e-24 81.1 In-house 123-298 (301) alignment 
Range on Protein: 1966-2126
Range on HMM: 123-298/301.0
DSNKCAQYWPEKVNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDSM---------------SMAITHYQLTVWPDHGV-PVDKIVMISFIDNIRLT
  .|| ||||.  .|...    . .  . | |.  .. ||| ..  | |                |. .. .|.| ||..|| .  . |. .  | |  .
tkskceqywpnseaeseefgp.ftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrq

HPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGET
. . | |.|||||..|.|.|... ..  |   | |   ....    .|...   |.| |||. |.. .   .|. .|
qkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1962-2119 3.1e-24 80.5 In-house 116-275 (307) alignment 
Range on Protein: 1962-2119
Range on HMM: 116-275/307.0
KITTDSNKCAQYWPEKVNETHKL-DDGIIIRTKTEEVHCWYTKRQLL-IT---KDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppkgPP
 | .   || |||| .  ..    . .  |  .   ..      .|. .|    |  . | .|.|.| . |||.|||  ..  | ... .|  .     |
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt....np

LVVHCSAGVGRTGTFIVIDTMLQRMKQ-ENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLAD
.||||||||||.|| . |  . ..| . .|  .. ... ..| ||   .||. ||.|.|. | .
vvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_PTPRN_pd Subfamily PTPRN 2148-2397 3.3e-24 80.1 In-house 28-287 (297) alignment 
Range on Protein: 2148-2397
Range on HMM: 28-287/297.0
ECEFQKEFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRD----TENDYINASWVEGYKT-GNWFIVTQIPLQNTQTDFWTMIHQQNCSV
.  ..||.| |..     || . . | .| ..||    |||.|.|| |..    ...|||||| .         .| || || .| .||| |. .| . |
kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

IVLLHPVGTDEIP---QFWPPQMGQAkkYQDLTVEHSLEK-EENDYQIITLELK-FKNESAHNVTLYYYKKWNiNTNNKPYLKPLFGILAK-NQLEN-GN
|| | ..  ...    ..|| .  .   |.   |.   |.   .|| . .. || .... .  || ...  |. ...  .  |.|.    | |.      
ivnltrleeegvkqckrywpdeGsev..yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswp.eegvPasaksllefrrkvnksyrGrs

RPIVVACNDGVGCSGTFLTAYSQIERAkTEGV--SDIFQFIRKARSQRPGLVDCLERYIYCHEL
 |||| | ||.| .|...     ..|  . ||   ||   . . | |||||| . ... ..   
cpivvhcsdGaGrtGvyilidlvlnrl.lkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2010-2142 7.4e-24 78.9 In-house 127-257 (392) alignment 
Range on Protein: 2010-2142
Range on HMM: 127-257/392.0
KDDDSmsMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQ
| ||    ... ...| |||..||     .. || ...  .     ||..||||||||||  | ||... . |.   .....|. .||..|  .||||||
kgdda..rtvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeq

YIYIHKSLADHIQCGETSFAIEKAQYRIKELRK
| .|. .. . .   .|   . .   ....|  
yafiygavledllwrntlipvvhftdhlqdlst
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2159-2402 2.9e-23 77.3 In-house 23-277 (307) alignment 
Range on Protein: 2159-2402
Range on HMM: 23-277/307.0
KELSDTTS-TISCSIAMDNQERNRFDYNLPYNHTRVILRD--TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCS-VIVLLHPVGTDEI
..|.. |  ...      |...||..     ...|....      ||| | ..      . ||..| ||.||| .||.|. |..   ||.| . . . .|
rvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielaki

--PQFWPPQMGQAKKYQDL----TVEH----SLEKEENDYQIITLELKFKNESaHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLENgnrPIVVACND
   |.|| . || . . .     .|.      |  .|.  .. ||.... ..|   .. . ...|  .   .  |  .  . | .  .|   |.|| |  
kceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqks.rtiqhlqwenwpdrgvpqinltainlleavrydtn...pvvvhcsa

GVGCSGTFLT-AYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
||| ||| .. .. |    . .   |. ..... ||||.  .    .|.| | .| || 
GvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_ptpA1_pd Subfamily ptpA1 2151-2357 7.5e-23 75.9 In-house 23-251 (418) alignment 
Range on Protein: 2151-2357
Range on HMM: 23-251/418.0
FQKEFELLKElSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDT---E-NDYINASWVEGYKTgNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLL
 ..|| ||.| |   |  |      |  .||.   || ||||| |.     | .||||| ...|    . ||.|| || || .||| |. .. | .||.|
ikeefrllee.svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivml

HPVGTD---EIPQFWPPQMGQAK--KY-------QDLTVEHSLEKEENDYQIITLELKFKNES-AHNVTLYYYKKW---NINTNNKPYLKPLFGILAK-N
     .   .  ..|| |.|  .   |          .||     .. . .||| ....  |  ....| | |. |   ||    .|. . |. |  . |
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

QL---ENGNRPIVVACNDGVGCSGTFLTAYS
|.    . | ||.| |. ||| .||| ||  
qiipssdrnvpiivhcsagvgrtgtfctavi
0046846 (Phosphotyrosine protein) phosphatases II 1965-2115 1.3e-22 75.8 In-house 60-167 (176) alignment 
Range on Protein: 1965-2115
Range on HMM: 60-167/176.0
TDSNKCAQYWPEKVNETHklddgiiirtkteevhcwytkrqllitkdddsmsmaitHYQLTVWPDHGVPVDkIVMISFIDNIRLTHPPkGPPLVVHCSAG
... ||..||||  .. .                                      .|. . ||||||| .   ...... ||      | | .||||||
lgrlkcpnywpeleklgi......................................qylhlpwpDhgvpdl.elllellefirealke.ggpvlVHCsaG

VGRTGTFIVIDtmlqRMKQENTLNIYDFLLQIRHQRI-TLVQTKEQYIYIHK
.|||||.....     .. |. |.... | ..| ||    ||| ||| ....
igRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflye
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2170-2401 1.6e-22 74.5 In-house 48-282 (290) alignment 
Range on Protein: 2170-2401
Range on HMM: 48-282/290.0
CSIAMDNQ--ERNRFDYNLPYNHTRVILRDT-ENDYINASWVEGYKTgnWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV---GTDEIPQFWPPQMG
 .|   |   ..||.      . |||||.|  . ||. | .|.| |.   ||.|| .|..|  |.| |. |.. ..||.|  .   |     |..| . |
rkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

QAKKYQDLTVEHSLEKEEnDYQIITLELKFKN-ESAHNVTLYYY--KKWNINTNNKPYLKpLFGILakNQLENGNRPIVVACNDGVGCSGTFLTAYSQIE
..  . ..||  |.|... | .||   |  .. .| ..  |...  | |  ..  .  |  |. .|    | . . |.|| |  |.| .||| .    ..
evltfGeitvlcseeddk.daniikktlsvrdkdsGkehklkhlkikswpdksvalstla.llrtl..rilrkasGpvvvhcsaGiGrtGtfvaievglq

RAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
        |. . .|  |  | . |.   .|.   |.| ..
illdGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1961-2120 3.3e-22 73.8 In-house 108-269 (285) alignment 
Range on Protein: 1961-2120
Range on HMM: 108-269/285.0
TKITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHC-W--YTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHpPKGPPL
| .    .||| |.|||. |  |.    |  |. .|       .    .. |.|  |  . . | |.  |||.  | |   || .   ..    ||  |.
tlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn.pkekpi

VVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
.|||||||||| ||. ||    |. ..  ... | . ..|  |.  ||.. |.....  | ..
cvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey
0048076 (Phosphotyrosine protein) phosphatases II 1973-2115 3.6e-22 74.0 In-house 2-137 (145) alignment 
Range on Protein: 1973-2115
Range on HMM: 2-137/145.0
YWPEKVNETHKLDDGIiIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPpKGPPLVVHCSAGVGRTGTFI
||| .. .   | .      . |. . .  .. | .| . .  .  ...|. . ||||||| .   ...|.. |.  .. .| | .||||||||||||..
ywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealk.eggpvlVHCsaGvgRtgtlv

VIDTMLQrmkqENtLNIYDFLLQIRHQRITLVQTKEQYIYIHK
... ||.    .. ..... | ..| ||   |.. .|......
aaylmll....lg.vsleealelvrsqrpgavpnpgqlrflye
0048179 (Phosphotyrosine protein) phosphatases II 2004-2115 3.7e-22 74.0 In-house 48-139 (144) alignment 
Range on Protein: 2004-2115
Range on HMM: 48-139/144.0
RqllitkdddsmsmaITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPpKGPPLVVHCSAGVGRTGTFIVIDTMLqrmkqENTLNIYDFLLQIRHQRITL
               ...|. . ||||||| .   ...|.. |.  .. .| | .||||||||||||..... |.     .. |.... | ..| .|   
e..............giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpga

VQTKEQYIYIHK
|.. .|......
vpnpgqlrfLle
subfamily_PTPRN_pd Subfamily PTPRN 1962-2121 3.8e-22 73.4 In-house 133-292 (297) alignment 
Range on Protein: 1962-2121
Range on HMM: 133-292/297.0
KI-TTDSNKCAQYWPEKVNETHKLDDgiiIRTKTEEVHC-WYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
..  .. ..|..|||.. .|.... .   ..  .| . |  |  | . .   . | . ..| .    ||..|||     .. |   .  ..  .  |.||
rleeegvkqckrywpdeGsevyhiye...vhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivv

HCSAGVGRTGTFIVIDTMLQRMKQ-ENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
|||.|.||||..|.|| .|.|...  . ..|   |  .| ||  ||.||.|. .. ...|. .
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_CG7180_pd Subfamily CG7180 1960-2125 4.8e-22 73.0 In-house 116-294 (296) alignment 
Range on Protein: 1960-2125
Range on HMM: 116-294/296.0
ITKITTDSNKCAQYWPEKVneTHKLDDgIIIRTKTEEVHCWYTKRQLLITKD----------DDSMSMAITHYQLTVWPD-HGVPVDKIVMISFIDNIRL
.|| .  .... .|||.|    ..  . |.. . .|.     ..|.. .||            .     ....|||.|.  . ||.    .| ..  .||
Ltktfdfakmypsywpnks..keqyge.ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl

TH-----PPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGE
        |.  |.||..| |..|.| .. ||  |. ...|. ....... ..|..|  ||...|.| ||   | ... |. 
wrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
0043147 (Phosphotyrosine protein) phosphatases II 2198-2396 1.8e-21 72.1 In-house 3-155 (172) alignment 
Range on Protein: 2198-2396
Range on HMM: 3-155/172.0
TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVgtdeipqfwppqmgqakkyqdltvehslekeendyqiitlELKFKNES
  .||||||....|   . ||.|| ||.||  ||| |........|| | .                                         ..  ....
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpelle

AHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIeraktEGVsDIFQFIRKARSQRPGLVDCLERYIYCHE
 ......|.     .. .  .|  .. .. . .... . |..| |  ||| .||.  ||  .     .|. .... ..  |..||| |   . |.....
rlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrflyy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2016-2156 1.9e-21 70.9 In-house 88-230 (440) alignment 
Range on Protein: 2016-2156
Range on HMM: 88-230/440.0
SMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKG-PPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIH
| .. .|.   |||.|||     .. .|...  ..   |  ||.||||||.||||  |..|..|.  |. . ..|. |.  .| .|  .||| ||| ..|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

KSLADHIQCGETSFAIEKAQYRIKELRKKNED-EECEFQKEFE
... . . ||.|    .    |.....  |   ... .|.|||
eavlegllcgdtliledditerveqiqwpnphtdksplqqefe
subfamily_egg_pd Subfamily egg 2150-2399 2.8e-21 70.5 In-house 15-267 (307) alignment 
Range on Protein: 2150-2399
Range on HMM: 15-267/307.0
EFQKEFELLKELSDTTStISCSIAMDNQERNRFDYNLPYNHTRVILRD----TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVL
|... .|.|.|..|  | .  ... .|.|. |       . .|| |.       .|.| |  |.|    | ||..| ||.||. ||| |..|...  ||.
elerrlevleesvdeis.lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

LHP-VGTDEIPQFWPPQMGQAKKY--QDLTVEHSLEKEENDYQIITLELKFkneSAHNVTLYYYKKWNINTNNKPYLKPLFGILAKnqLENGNRPIVVAC
|   . ... . .||    .. ..    | .|    ... |      .||       .    . ..|. . ||   .   . .| |  | |  .|.|| .
ltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl...vGgddeerflehwqgdvnnssdvysplrvlrk..lrnlskpvvvqd

NDGVGCSGTFLTAY---SQIERAkTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLC
 .||  ..|....     .. |      | . . .   | .|.  |..  .|.. . |. 
ilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1968-2120 4.4e-21 69.9 In-house 128-286 (305) alignment 
Range on Protein: 1968-2120
Range on HMM: 128-286/305.0
NKCAQYWPEKVNETHKLDD---GIIIRTKTEEVHCWYT------KRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRlthPPKGpPLV
.||..|.. | ... ....    |... .. .   . .      ..  |. .   . .  .|||    ||| |||   . .. .. . |   | || |.|
kkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar...pskg.piv

VHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFL-LQIRHQRITLVQTKEQYIYIHKSLADH
||||||.||||. .... .|... . . ..  | .  .|| ||   .|| .||...|. . ..
vhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2166-2401 5.3e-21 69.9 In-house 33-270 (288) alignment 
Range on Protein: 2166-2401
Range on HMM: 33-270/288.0
STISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHP---VGTDEIPQFWPPQM
|  . .  ..|  |.|..     . ||| | |  . ||.|  |   |  . .| .| ||. |   .| |. ...   ||.|      | ..  ...| ..
sidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

GQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESAHN--VTLYYYKKWNINTNNKPYLKPLfGILakNQLENGNRPIVVACNDGVGCSGTFLTAYSQIE
|.. ... |      .... |  .    |. ..|  ..  |   ....|. ..  . || ||  .|  . |.. ..|||| .. ||| .||.      .|
GekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylspl.rll..evlkslqkPivvhssaGvGrtgtlililiale

RAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
 .. .  . | ... | | .|   . .  .|.| | .. |.
slrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
0044763 (Phosphotyrosine protein) phosphatases II 1967-2115 1.5e-20 69.1 In-house 63-165 (178) alignment 
Range on Protein: 1967-2115
Range on HMM: 63-165/178.0
SNKCAQYWPEKVNethklddgiiirtkteevhcwytkrqllitkdddsmsmaiTHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGVG
 .|| .||||. .                                         .|. . .||||||     .  |.. |.  ...|| | .||||||||
flkcdpywpeeag........................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

RTGTFIVIDTMLQRmkqenTLNIYDFLLQIRHQRItLVQTKEQYIYIHK
|.||..... |...      |.... . ..| .|   |.. .|. ....
Rsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLye
0046846 (Phosphotyrosine protein) phosphatases II 2192-2402 4.9e-20 67.5 In-house 4-173 (176) alignment 
Range on Protein: 2192-2402
Range on HMM: 4-173/176.0
RVILRDTENDYINASWVEGYktgnWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPP----QMgqakkyqdltvehslekeendy
|..  |   |||||... |.    ..|.|| || .|  ||. |.........| |      .   .|..||     ..                      
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

qiitlelkfknesahnvtL-YYYKKWNINTNNKPYLKPLFGILAKNQLENgnRPIVVACNDGVGCSGTFLTAYsqieRAKTEGVSDIFQFIRKARSQRP-
                    ...     .. .  .|  |. .. . . |.  .|..| |  |.| .||.. ||      ..|   .... ... |.||| 
..................qylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRpl

GLVDCLERYIYCHELLCEYA
| |   | | ...| .... 
gavqtpeQyrflyefellll
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1966-2134 1.3e-19 65.4 In-house 109-272 (290) alignment 
Range on Protein: 1966-2134
Range on HMM: 109-272/290.0
DSNKCAQYWPEKVNETHKLDdGIIIRTKTEEVHCWYTKRQLLITKDdDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRlthpPKGPPLVVHCSAGV
..  ||.| ||.|.|  |.. |. .. |  | .    .|.|... | |   . .||..|  | .  |. |.....| |....     .. | .|||  |.
slfaCakYvpesvgeelkfk.gltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGi

GRTGTFIVIDTMLQRMK-QENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQ
 |  ..  |.   | .  ... ... | | ..|.|| ......... ..   .   ..    .|| |. .
SrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeete
0051082 (Phosphotyrosine protein) phosphatases II 1968-2115 1.5e-19 65.6 In-house 47-147 (151) alignment 
Range on Protein: 1968-2115
Range on HMM: 47-147/151.0
NKCAQYWPEKVnethklddgiiirtkteevhcwytkrqllitkdddsmsMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLthpPKGPPLVVHCSAGVGR
..|..|.||                                        . ..|.... |||.|.|.    ...|.. ..    .|. |..||||||.||
gycpeylpelg......................................ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgR

TGTFIVIDTMLQRmkqentLNIYDFLLQIRHQRITLVQTKEQYIYIHK
|||..... ||..      ..... | ..| .|  .||...|......
TGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1952-2115 6.1e-19 63.0 In-house 99-289 (297) alignment 
Range on Protein: 1952-2115
Range on HMM: 99-289/297.0
EAVELYSYITKITTDS-NKCAQYWPEKVNETHKLDDGIII--RTKTEEVHCWY-TKRQLlITKdddSMSMAITHYQLTVWPDHGVP-----VDKI-----
. |     ..|.  |  .||| |||. |.|  |  | ..    . ..| .  . |. || | .   | |  ..| |   |||||||     ...      
qdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelql.iyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvc

-------VMISFID-----------NIRLTHpPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHK
       .|.. ..            .|  . |.  .|.|||||||||.|  .  |..|......   ..  .| ..|.||  |||| ||. ....
scciavpmmlalvemftamvflqleslraem.prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyd
0049772 (Phosphotyrosine protein) phosphatases II 2012-2123 1.2e-18 63.4 In-house 173-282 (314) alignment 
Range on Protein: 2012-2123
Range on HMM: 173-282/314.0
DDSMSMAITHYQLTVWPDHGVPvDKIVMISFIDNIRLThpPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKqentLNIYDFLLQIRHQRI-----TLVQT
..  . .. .|  . .||...| .   . .|.. |.    .|| |..|||.||.||||||.|.. .. ...    ... . | ..| .|       ....
pelferlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieq

KEQYIYIHKSLADHIQC
 |||..|.. | .... 
leqyefilealleylkf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1962-2113 2.2e-18 61.0 In-house 124-273 (301) alignment 
Range on Protein: 1962-2113
Range on HMM: 124-273/301.0
KITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEE-VHCWYTKRQLLITKDDDSM-SMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppkgPPLVV
|.    .||..| | |..|. ...   |  ...|  ..   .||.| ..   . . . ..|||| . |.|.|||  .. .  ... .. ..     |.||
kvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYI
|||||.||. .||  . . .... ..|... . | ..|..| . |||..|  ..
hcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1964-2120 6.6e-18 59.5 In-house 116-276 (287) alignment 
Range on Protein: 1964-2120
Range on HMM: 116-276/287.0
TTDSNKCAQYWPEKvNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNI----RLTHP-PKGPPLV
    .|| .||||. .   ..    ..  . .  .  |. | | . . .   .  .  ..|  |||....   . .| |. ..     |.    .  |||
eearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlv

VHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
||...|.||.|... . ....|...   ...   ....| .| .|||.  |. .. ..|. .
vhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1967-2118 8e-18 59.5 In-house 121-268 (288) alignment 
Range on Protein: 1967-2118
Range on HMM: 121-268/288.0
SNKCAQYWPEKVNETHKLDDG-IIIRTKTEEVHCWYTKRQLLITKDDDSMSmAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPpkgpPLVVHCSAGV
 .| |.|.| |. |. ..     ... | ....   .   | |.|  .     . .  |  |.|.||| . .  . ... .. ..     |.|||.||||
keksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGv

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
|||||.|.|  .|. .. .. | |  .| . | .|   .||. ||.|.|. . 
Grtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1966-2127 1.1e-17 58.8 In-house 120-282 (312) alignment 
Range on Protein: 1966-2127
Range on HMM: 120-282/312.0
DSNKCAQYWPEKVNETHkLDDGIIIRTKTEEVH------CWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppkgPPLVV
 |.|||.|  . |   . |.|  .      |.          |.| | .          . ||| . |||||.|        ..  ..  .     |.. 
gsekcakyisdivgfvd.ledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpvia

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETS
|||||||||||...|..|.  ...    |. | .. .|..|   |..  ||.|  ... . . .    
hcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_CG42327_pd Subfamily CG42327 2171-2310 1.1e-17 58.7 In-house 23-172 (319) alignment 
Range on Protein: 2171-2310
Range on HMM: 23-172/319.0
SIAMDNQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKT-GNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLH---PVGTDEIPQFWPPQM
 . .  ....|.   .|  .|||.|.    | .. |..||.| ||.   | .| .|..|... .||| .. .|.  ||| |      | .  ....|.. 
evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke

GQ--AKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYkKWN
.    . | |. |     . .. | | || ||  ..| . ..| |.| || 
tldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1963-2120 2e-17 57.8 In-house 116-268 (281) alignment 
Range on Protein: 1963-2120
Range on HMM: 116-268/281.0
ITTDSNKCAQYWPEKVNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDsmSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppkgPPLVVHCS
. |. .|||.|.| .     ..|  . .  .   |       .| .. . .  .  |||.    |||  ||    ||.  . .||        | |.|||
letnrekcaeyfprnahcclqfdk.lsvsyedstvnkslvttrlnlsyege..trlithwlwkewpdwqvpessevmlkilrkirars....tppvihcs

AGVGRTGTFIVIDTMLQRMKQENTLN-IYDFLLQIRH-QRITLVQTKEQYIYIHKSLADH
|||||.||.. ..  || ..   ||  | . . ..|   | . ||| .||. | | | | 
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2176-2406 2.3e-17 57.9 In-house 35-274 (285) alignment 
Range on Protein: 2176-2406
Range on HMM: 35-274/285.0
NQERNRFDYNLPYNHTRVILRDTENDYINASWVE-GYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLL---HPVGTDEIPQFWPPQMGQAKKYQDL
| . ||.      . |||.|.. . ||| |||.    |  . .| || || .| .||| ||.|.. . ...|      | ..   ..| ..|.  |.   
npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

TVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYK---KWNINTNNKPYLKPLFGILAK-NQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEG
 .  .  |||     |   |   | | | .  ||  .    |  .       .|.  .    ....  ..||.| |. ||| . ||.       |   . 
eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenp

VSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGML
  .... .|. |. |   |.   .... . .| ||  |  
niemldivremramrfqavqshmqflflyvvlmeyfigeg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2169-2309 5.7e-17 56.5 In-house 24-174 (297) alignment 
Range on Protein: 2169-2309
Range on HMM: 24-174/297.0
SCSIAMDN--QERNRFDYNLPYNHTRVILRD--TENDYINASWVEG--YKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLL---HPVGTDEIPQFWP
| | |  |    .||.   | .. ||| |.   ||.||||| .|     ..   .|..| ||..|  ||||.. .|.  |||..      | |    .||
sfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

PQMGQAKKYQDLTVEHSLEKEENdYQ---IITLELKFKNESAHnVTLYYYKKW
   .. .|  |. ||.  .  .. ..   .  |.| ...|| . |.   .  |
svvqerlkagdvvveflsstsde.fdrviltelqliyrsesrv.vrhvqflsw
0049260 (Phosphotyrosine protein) phosphatases II 2208-2396 1.1e-16 56.3 In-house 2-144 (152) alignment 
Range on Protein: 2208-2396
Range on HMM: 2-144/152.0
VEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWppqmgqakkyqdltvehslekeendyqiitlelkfknesahnvtly
..||. .. || || |. ||  ||| |........|| |     .     .| .                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

YYKKWNINTNNKPYLKPLFGILAKNQ---LENGNRPIVVACNDGVGCSGTFLTAYSQIerakteGVSDIFQFIRKARSQRPGLVDCLERYIYCHE
 |. ...  .. | |  |. .| .     ... . |..| |  ||| .||.  ||  .         .......  |..||| |   . .....|
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
PTPc_DSPc_SM00012 2301-2398 1.7e-16 55.7 In-house 2-103 (105) alignment 
Range on Protein: 2301-2398
Range on HMM: 2-103/105.0
VTLYYYKKWNINTNN---KPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTE-GVSDIFQFIRKARSQRPGLVDCLERYIYCHE
|. |.|..|         .. |. |  .  ... .. . |.|| | .||| .||| ...  ... ..| .  ||||.... |.||||.|. .| |.....
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

LL
 |
al
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2167-2357 2.6e-16 54.2 In-house 41-236 (301) alignment 
Range on Protein: 2167-2357
Range on HMM: 41-236/301.0
TISCSIAMDNQERNRFDYNlPYN-HTRV-ILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV---GTDEIPQFWPPQ
 |  | |  .....|..   | . .| | .. | .   | | |..     . ||.|| ||.||. |||.|. | .   ||.|       ..   .. | .
hitesyaylpkdkhryptv.PckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvk

MGQAKKYQDLTVEHSLEKEENDYQIITLELKFK----NESAHNVTLYYYKKWNINTNNKPYLKpLFGILakNQLENGNRPIVVACNDGVGCSGTFLTAYS
...  . .  ...   ..   . .|.  .|. .    . ... || | |..|  .   | . . || ..  . . . ..|||| |..|.| | .|...  
isekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshae.lfdlm..elvkksekPivvhcsaGiGrsvafigtey
0051082 (Phosphotyrosine protein) phosphatases II 2200-2397 2.8e-16 55.0 In-house 3-148 (151) alignment 
Range on Protein: 2200-2397
Range on HMM: 3-148/151.0
NDYINASWVEGYktgnwFIVTQIPLQntqtDFWTMIHQQNCSVIVLLHPVG-TDEIPQFWPPQMgqakkyqdltvehslekeendyqiitlelkfknesa
.||||.|.|.|.     ..... ||.    ||. .........|| | .   ..  |...| .                                     
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg....................................

HNVTLYYYKKWNINtnNKPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERaktegvSDIFQFIRKARSQRPGLVDCLERYIYCHEL
..|. ...  |     . | . . .  . .  |...| |..| |. |.| .||.  .|  ...       .... ..  |..|||.|   . .....  
ievlhipildwpdp..glplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1963-2113 5.1e-16 53.0 In-house 126-280 (302) alignment 
Range on Protein: 1963-2113
Range on HMM: 126-280/302.0
ITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYT-KRQLL-----I--TKDDDSMSMAITHYQLTVWPDHGVPVDKIVMisfIDNIRLTHPPKG
.  . .|||.|. .||... |.    .   . ..    .| |...      |  .|  . . ...   . . ||||| | .       .| ..     | 
vedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeayta...ldilkfcesykk

PpLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYI
  ..||||||||||||.. |   .|  ..... .. . .| .|. |   ||...| ||.
n.vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1942-2117 1.8e-15 51.5 In-house 164-340 (350) alignment 
Range on Protein: 1942-2117
Range on HMM: 164-340/350.0
SRRKNPTKTEEAVeLYSYITKITTDSNKCAQywpEKVNETHKLDDGIIIRTKTEevhcwytkrqllitkdddsmSMAITHYQLTVWPDHGVPVDKIVMIS
|...|.. ..... |||   |...  |   .   .. .  .. .   |  . ..                     . . . |.  |.| .. .. . ...
skwenimgindss.lysadvkkeasdndnis...ddndlkdnnsltaitlaasd....................PyvvyqlqvknWkDlslllnPesilq

FID-------NI---RLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQ-----RMKQE--------NTL--NIYDFLLQIRHQRITLVQTKEQYIYIHKS
 ..       .       .  ...|..||||||||||||.. .| .|.     .. ..        . .   |   ....|.||| .||...|.|.|...
alevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYea

L
|
l
0044763 (Phosphotyrosine protein) phosphatases II 2187-2397 3.3e-15 51.6 In-house 1-166 (178) alignment 
Range on Protein: 2187-2397
Range on HMM: 1-166/178.0
PYNHTRVILRDTEN----DYINASWVEGYktgnwFIVTQIPLqntqTDFWTMIHQQNCSVIVLLHPVGT---DEIPQFWPPQMGqakkyqdltvehslek
|. .|||.|   |.    ||||||.. ..     ..... |      |.. .........|| | .       . .. || ..|                
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

eendyqiitlelkfknesahnvtlYYYKKWNINTNNKPY----LKPLFGILAKNQlENGNRPIVVACNDGVGCSGTFLTAYSQIERakteGVsDIFQFIR
                        . |....|  .. |     .  .. .. . . .. ..|..| |. ||| |||.  ||  ...    |. .... |.
........................iqylhipipDhgvpdllehflefvefieeal.dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaie

KARSQRPgLVDCLERYIYCHEL
  |..||  |   . . ...|.
lvrerRp.ivpnpgqlrqLyef
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2178-2401 3.7e-15 50.3 In-house 57-288 (305) alignment 
Range on Protein: 2178-2401
Range on HMM: 57-288/305.0
ERNRFDyNLPYNHTRVIL--RDTENDYINASWVEGYKT-GNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLH---PVGTDEIPQFWPPQMGQAKKYQDL
 .||.. ..| .   ...  . .  ||| | .|       . ||..| ||..|  .|| |. |..   ||.|     .|     |.||  .|. .. .  
tknryq.dvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksg

T-VEHS-LE---KEENDYQIITLELKFKNESAHNVTLYYYKKWNINTNNKPYLKPLfGILakNQLENGNRPIVVACNDGVGCSGTFLTAYSQIER-AKTE
  ||        . ... || .|.| .  .    |    . .|         |  |  .|    .   . |||| |  |.| .|| ..    .|. |.  
ivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltsl.ell..sairgskvpivvhcsagigrtgtivaieyilekiaenk

GVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
 .  . ....  | ||   ..   .|.. | .. .|
pcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_CG42327_pd Subfamily CG42327 2054-2118 1.5e-14 48.4 In-house 247-312 (319) alignment 
Range on Protein: 2054-2118
Range on HMM: 247-312/319.0
GPPLVVHCSAGVGRTGTFIVIDTMLQRMKQE-NTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
  ||||||| ||||||. |  |  ......  ....| . . ..|..|   |.||||| .|.| | 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1965-2112 3.7e-14 47.4 In-house 65-212 (255) alignment 
Range on Protein: 1965-2112
Range on HMM: 65-212/255.0
TDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEvHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFidnIRLTHppKGPPLVVHCSAG
 . .|| .|.| . .|  || |  .. ||.   .     .... |  .      ..||. . |...  | .   .      ... .  .  ..|||||.|
egvekcssyfplekdeklkladvnvtttkssa.dvvlrtleitstlgekkkthtvkhysykGWieknaPelareilni...lkvvr..dsksvvvhCstG

VGRTGTFIVIDTMLQ----RMKQENTLNI--YDFLLQIRHQRITLVQTKEQYIY
.||. .|.... . |     ... .| ..    .| ..|..| . ..|  |  .
iGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2176-2402 5e-14 46.6 In-house 37-269 (281) alignment 
Range on Protein: 2176-2402
Range on HMM: 37-269/281.0
NQERNRFDyNLP-YNHTRVILRD-----TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV---GTDEIPQFWPPQMGQAK
|...||.  |.|  . .|| |.         ||| | ..        .|.|| | ..|..||| || |.| . ||.|  .     ..  ...| .   . 
nnkknryl.nipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahccl

KYQDLTVEHSLEKEENDYQIITLELKFKNESaHNVTLYYYKKWNINTNNKpYLKPLFGILAKnqLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTE-
... |.|..     ..      |.| .. |. . .| . .|.|      .   . .. || |  .     | |. |  ||| |||...    ..  ..  
qfdklsvsyedstvnkslvttrlnlsyeget.rlithwlwkewpdwqvpe.ssevmlkilrk..irarstppvihcsagvgrsgtlmaveialqsihshf

GVSDIFQFIRKARS-QRPGLVDCLERYIYCHELLCEYA
 . || | . . |   |   |. |..|.   ..| .. 
tlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2188-2379 9.3e-14 46.2 In-house 30-239 (290) alignment 
Range on Protein: 2188-2379
Range on HMM: 30-239/290.0
YNHTRVILRDT----ENDYINASWVEgYKTGNWFIVTQIPLQNT-------QTDFWTMIHQQNCSVIVLLHPVGTDE-------IPQFWPPQMGQAKKYQ
 ..|||.|..      .||| |. |  .  |  .|.|| |....         .|| |..| .   .| |  .   .         .. | ..|.  |..
veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

DLTVEHSLEKEENDYQIITLELKFKNESAHNVTLYYYKKWNINtNNKPYLKpLFGILAkNQLENGNRPIVVACNDGVGCSGTFL---TAYSQIE-RAKTE
.|||.     .|.| .. .|..|| .|  . || . .| ||   | ..  | ..  |. ..... . |..| | ||.  | ..     .|  |    .  
gltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnkl.nvqedtk.tllsli.qkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv

GVSDIFQFIRKARS
 . |. . .|| | 
kledvlkalrkqra
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2057-2124 1e-13 45.5 In-house 1-68 (69) alignment 
Range on Protein: 2057-2124
Range on HMM: 1-68/69.0
LVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCG
.|||||.| ||||||| |   . |.| |  ..|.. .  .|  |  .|  . .||.|| .|.. .. |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2138-2403 1.2e-13 45.5 In-house 11-288 (305) alignment 
Range on Protein: 2138-2403
Range on HMM: 11-288/305.0
KELRKKNEDEECEFQKEFELLKELSDTTSTISCSIAmDNQERNRFDYNLPYNHTRVILRDT-ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIH
| ...  |     ...||  .| . |     .   | .....||.      .. || |. .   .|| | .|      . || || ||..| .||| |  
kfvkrtlekgpaglraefvamkrfndfekmkafkea.qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymcl

QQNCSVIVLLHP---VGTDEIPQFWPPQMG----QAKKYQDLTVEHSLE-----KEENDYQIITLEL--KFKNESAHNVTLYYYKKWNINTNNkPYLKPL
|..   | .|      |.    .... . .      .| | ..|          ... . ..   .|  .   |.|. || |..  |       .    .
qdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvp.aadlai

FGILAKNQLENGnrPIVVACNDGVGCSGTFLTA-YSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
. .|.| .   |  |||| |  |.| .|. .   |   .    . . |  . ..| | ||   ..  ..|.. |... .| .
lellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2166-2310 1.5e-13 44.9 In-house 86-231 (244) alignment 
Range on Protein: 2166-2310
Range on HMM: 86-231/244.0
STISCSIAMDNQERNRFDYNLPYNHTRVILRD--TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVgtDEIPQFWPPQMG
| .  ..  .|  .||    ||..  || |      | |||||.|        .|.|| || .|  ||| |. ..   |.|.|  |  .|  ..||    
svmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsv..eeedeywpdsep

QAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWN
     .|.||  .   |  . .   ||..   |||   .|..   .| 
lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwp
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2214-2394 1.7e-13 45.2 In-house 4-196 (199) alignment 
Range on Protein: 2214-2394
Range on HMM: 4-196/199.0
GNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTD---EIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFK---NESAHNVTLYYYK
   .|.|| ||..| .||| |. .     ||..     .   . | .||     . ||  |.|       . || | .| |  .     |. ... | . 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

KWNINTNNKPYLKPLFGIL----AKNQLENGNRPIVVACNDGVGCSGTFLTAYS---QIERAKTeGVSDIFQFIRKARSQRPGLVDCLERYIYC
 |. .|  .  |   | .     .|.  .. . |..| | || | .| |..        | .||  | |.|.  .. |  | |..  |. | . 
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2208-2309 1.8e-13 44.7 In-house 229-328 (440) alignment 
Range on Protein: 2208-2309
Range on HMM: 229-328/440.0
VEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDEIPQFWPPQmGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNEsAHNVTLYYYK
.|||   | || ||.||. |  ||| ..|. . | |..|  .       .|| .  ..  .  .|| |   .. |  .. |||||.|.|  |..  .  .
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvn.trsvtfgpftvghkgsenmnrvkvrtlelkykee.vheirqfevq

KW
 |
tw
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2216-2394 2e-13 45.0 In-house 5-195 (198) alignment 
Range on Protein: 2216-2394
Range on HMM: 5-195/198.0
WFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTD---EIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFK---NESAHNVTLYYYKKW
 .|.|| ||..| .||| |. .     ||..     .   . | .||     . ||  |.|       . || | .| |  .     |. ... | .  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

NINTNNKPYLKPLFGIL----AKNQLENGNRPIVVACNDGVGCSGTFLTAYS---QIERAKTeGVSDIFQFIRKARSQRPGLVDCLERYIYC
. .|  .  |   | .     .|.  .. . |..| | || | .| |..        | .||  | |.|.  .. |  | |..  |. | . 
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfi
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2058-2124 2.1e-13 44.4 In-house 1-67 (69) alignment 
Range on Protein: 2058-2124
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCG
|||||.| ||||||| |   . |.| |  ..|.. .  .|  |  .|  ...|..|| .|.. .. |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
fn3 Fibronectin type III domain 1533-1618 2.3e-13 43.2 Pfam-A 6-84 (85) alignment 
Range on Protein: 1533-1618
Range on HMM: 6-84/85.0
FETYNITAYEMTFTWLPPLecFRNGDIIKYSLSCSFNNATHsdiqqSLQHQITSKRENRFTLHNLYPFTNYTCHLAAANGIGEGPA
.   ..|. ..|..| ||    ..|.| .|.. ..  . ..       ... ... ....||..| | |.|.. ..| || ||||.
lsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_hpo-7_pd Subfamily hpo-7 1965-2112 4e-13 43.9 In-house 71-218 (263) alignment 
Range on Protein: 1965-2112
Range on HMM: 71-218/263.0
TDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEvHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLThppKgpPLVVHCSAG
 . .|| .|.| . .|  || .  .  ||. .       ..|| | ..      ..||. . |...  | . . ..  ..  |     |  .||||||.|
egvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvarns...k..slvvhcstG

VGRTGTFIVIDTMLQ----RMKQENTLNI--YDFLLQIRHQRITLVQTKEQYIY
.||.  | |.... |     ... .| ..    .| ..|..| . ..|  |  .
iGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
fn3 Fibronectin type III domain 1632-1708 5.9e-13 42.0 Pfam-A 1-84 (85) alignment 
Range on Protein: 1632-1708
Range on HMM: 1-84/85.0
SEPENLTIISTSSSSLVLTWSKPIQPNGIIVKYTINCS---SGI-FDNETIDNI---VVLNGLVPYTNYTCSVSAHTRIGVGPA
|.||||......|.||.|.||.| ...| |..|.. ..   .|    . |...    |.|.|| |.|.|...| |... | ||.
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_PTPN9_pd Subfamily PTPN9 2331-2403 5.9e-13 43.5 In-house 219-291 (297) alignment 
Range on Protein: 2331-2403
Range on HMM: 219-291/297.0
LENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 .  . |||| |  |.| .||| |    ..| ...|. |... ... |.||   .   |.| .|.  . ||| 
ghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2174-2294 1.2e-12 42.1 In-house 50-174 (310) alignment 
Range on Protein: 2174-2294
Range on HMM: 50-174/310.0
MDNQERNRFDYNLPYNHTRVILR---DTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDEIPQ---FWPpQMGQAKK
 ..  .||.   .  . .|| |.      .||| | .|      . ||..| ||| |  ||| || |. .  |.||  || .  |.   .||  .| .. 
kkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp.slgvtet

YQDLTVEHsLEKEENDYQIITLELKFK
|  . |   | .  ....|  | . | 
ygcirvtn.lsesseefeicnlavtfv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2009-2121 4.1e-12 40.1 In-house 173-285 (302) alignment 
Range on Protein: 2009-2121
Range on HMM: 173-285/302.0
TKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKE
  .. | |. .. | || |... |||    .|  . ..   . .   ..|.    |.|| |.|..  . ........  || . . .|| || . |.. .
lPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslk

QYIYIHKSLADHI
||. .. .|. .|
Qyvslyialllyi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2161-2247 5.9e-12 39.8 In-house 32-115 (303) alignment 
Range on Protein: 2161-2247
Range on HMM: 32-115/303.0
LSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTenDYINASWVEgYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLH
 |    ..|    ..| ..|||   .  .|..| | |.   || ||..|  .. .  |.||.||. | .||| || .|.  ...|| 
vsylppsvsknqfvknmdknrfvdvicldhskvklsds..syihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvllll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2023-2118 2.5e-11 37.7 In-house 196-287 (310) alignment 
Range on Protein: 2023-2118
Range on HMM: 196-287/310.0
QLTVWPDHGVPVDKIVMISFidniRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
.   ||| ||| .|   .      ||    .  | |||||||..|... . ..  ...... . ... .   .....|.  .||. ||..|..   
kwpnwpdrgvpdekchtvpq....rllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2171-2258 4.3e-11 37.1 In-house 42-150 (350) alignment 
Range on Protein: 2171-2258
Range on HMM: 42-150/350.0
SIAMDNQERNRFDYNLPYNHTRVILR------------DTENDYINASWVEGY-----KTGNW-FIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTD
|  ..   .||.   |||.|.||.|.               ||||||....          .. .| || ||..|  ||...| . .  ||. | .    
seGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel

---EIPQFW
    . ..|
nlekcyrYW
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2186-2310 3.4e-10 34.3 In-house 3-122 (130) alignment 
Range on Protein: 2186-2310
Range on HMM: 3-122/130.0
LPYNHTRVIlrdtENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVgtDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQ
|... .|.     .|.|||||.|      . .. || || .| .||| |. ..   |.|.|  |  .|  ..||         .|..|  .  .| .  .
lefevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsv..eeedeywpdsePlewyeediivtltdrdefknik

IITLELKFK-NESAHNVTLYYYKKWN
   || . . ||| . .|..   .| 
asnleiesdlneshqaltmfqisnwp
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1971-2114 4.8e-10 33.9 In-house 48-197 (199) alignment 
Range on Protein: 1971-2114
Range on HMM: 48-197/199.0
AQYWPEKVNETHKLDdGIIIRTKTEEVHCWYTKRQLLITKDDDS--MSMAITHYQLTVWPDHGVPVDkIVMISFIDNIRL----THPPKGPPLVVHCSAG
. |||   . | |    . . |||  ..  ||   |..|..  .   .  |.|||.| | ..  |    ... |.   |         |  |..|||| |
pfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdg

VGRTGTFIVIDTMLQRMKQENT--LNIYDFLLQIRHQRITLVQTKEQYIYIH
 | || |. .|  ..  .. .|  .....   ..|  |  .. . ..| .|.
qgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1971-2114 4.8e-10 34.0 In-house 47-196 (198) alignment 
Range on Protein: 1971-2114
Range on HMM: 47-196/198.0
AQYWPEKVNETHKLDdGIIIRTKTEEVHCWYTKRQLLITKDDDS--MSMAITHYQLTVWPDHGVPVDkIVMISFIDNIRL----THPPKGPPLVVHCSAG
. |||   . | |    . . |||  ..  ||   |..|..  .   .  |.|||.| | ..  |    ... |.   |         |  |..|||| |
pfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdg

VGRTGTFIVIDTMLQRMKQENT--LNIYDFLLQIRHQRITLVQTKEQYIYIH
 | || |. .|  ..  .. .|  .....   ..|  |  .. . ..| .|.
qgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_eak_pd Subfamily eak 2165-2312 6.6e-10 32.9 In-house 41-192 (332) alignment 
Range on Protein: 2165-2312
Range on HMM: 41-192/332.0
TSTISCSIAMDNQERNrFDYNLPYNHTRVILRDTE---NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVL-LHPV--GTDEIPQFW
  .|| .  ... .||     .||..  | |  .    . ||||| .|  . |. .|.| |. ..    || |. .|.   ||  |. |  . ..  ...
llsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNEsAHNVTLYYYKKWNIN
| .  .  |.  | ||     ..| ..   |||.  || .|.|  | .  |   
pdktreelkfGildverkefvkrniletrllelskGne.thrvlhykvfGwtet
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2303-2400 8.5e-10 32.5 In-house 93-192 (440) alignment 
Range on Protein: 2303-2400
Range on HMM: 93-192/440.0
LYYYKKWNINTNN---KPYLKPLFGiLAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLC
 |.|. |  .       | || .   . ..| . || |..| |. |.| .|  ..  | .  ||     ||| ||   |..|| .|.. |.| . || . 
qyhyqgwpdkgvpkfagpvlkmiqd.vnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavl

E
|
e
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2146-2221 1.2e-09 32.2 In-house 20-94 (95) alignment 
Range on Protein: 2146-2221
Range on HMM: 20-94/95.0
DEECEFQKEFELLKELSDTTSTISCSIAmdNQERNRFDYNLPYNHTRVILRD-TENDYINASWVEGYKTGNWFIVTQ
. . ||..||  .   | .. |.  | |  |  .|||   .||. |||.|    . ||||| .|.||   | .| .|
nsdqefdnefksismtsgapytvgssea..nipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq
subfamily_eak_pd Subfamily eak 2037-2125 1.5e-09 31.7 In-house 221-309 (332) alignment 
Range on Protein: 2037-2125
Range on HMM: 221-309/332.0
IVMISFIDNIRLThPPKGPPlVVHCSAGVGRTGTFIVIDTMLQRM--KQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGE
 .. |.. .   | ||   | .. .. |  |.|.|.||| ... .  |..|.  . |..|.....||  | .. |. .|.. . |...  .
allsstlkkyiht.ppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
0048076 (Phosphotyrosine protein) phosphatases II 2278-2400 2.9e-09 32.3 In-house 25-141 (145) alignment 
Range on Protein: 2278-2400
Range on HMM: 25-141/145.0
EKEENDYQIITLELKFKNESAHNVTLYYYKKWNINTNNK-PYLKPLFGILAKNQLENgnRPIVVACNDGVGCSGTFLTAYSQIEraktEGvSDIFQFIRK
 |. . . ...|   ............|.  .  .. .   .|  .. .. . . |.  .|..| |. ||| .||.  ||  ..    .|  .... ...
lkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealel

ARSQRPGLVDCLERYIYCHELLCE
 |||||| |   . .....|.. |
vrsqrpgavpnpgqlrflyefele
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2173-2246 4.3e-09 30.3 In-house 31-107 (332) alignment 
Range on Protein: 2173-2246
Range on HMM: 31-107/332.0
AMDNQERNRFDYNLPYNHTRVIL--RDTENDYINASWVEGYKTGNWFIVTQIPLQN-TQTDFWTMIHQQNCSVIVLL
 ..| . ||  .   ..|.|| |  .| ..|. |||||.||   . .|..| |... |.  || |. ... |.|...
flnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf
subfamily_CG42327_pd Subfamily CG42327 1968-2047 4.6e-09 30.4 In-house 112-191 (319) alignment 
Range on Protein: 1968-2047
Range on HMM: 112-191/319.0
NKCAQYWPEKV-NETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLtVWPDHGVPVDKIVMISFIDNIR
..||.|.| |   . ..|   | .  |  ||.  |    ||. . |...|  .|||    |.. .|| ..  .|. . ..|
kvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2227-2383 5e-09 30.6 In-house 40-202 (255) alignment 
Range on Protein: 2227-2383
Range on HMM: 40-202/255.0
TQTDFWTMIHQQNCSVIVLLHPV---GTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFK-NESAHNVTLYYYKKWnInTNNKPYLKPl
|   |. .| |.. .|.|.|      | ..  ...| .  . .|..|..|  .    .   . ... ...     .|.|. | || | |  .| | |   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGW.i.eknaPelar.

fGILAKNQLENGNRPIVVACNDGVGCSGTFLTA---YS----QIERAKTEGVsDIFQFIRKARSQRPG
  ||   ..    ...|| |. |.| | .|  |   |     ......| .. |  ..... ||.|..
.eilnilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetvel.dylslleelrskrkr
I-set Immunoglobulin I-set domain 578-656 5.2e-09 27.8 Pfam-A 11-88 (90) alignment 
Range on Protein: 578-656
Range on HMM: 11-88/90.0
TVNIECTIILNTPVGPGIQPNVTWYYDATDITLSGSLLRNNDIvFISTLTIDSIQVSDAGVYHCNAGIDSNVTTSNISV
.|... .. |.  |    .|.|.|. | .... | ..  ...   ..||||....|||.| |.|.|   .   ......
evseGesvelectveGepepsvsWakdgselkssqrvkvtvee.aeytLtIsnvevsDeGkYtckatnsagkaeakaeL
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2006-2138 6.7e-09 29.8 In-house 162-297 (303) alignment 
Range on Protein: 2006-2138
Range on HMM: 162-297/303.0
LLITKDDDSMSMAITHYQltVWPDHGVPVD---KIVMISFIDNIRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQE-NTLNIYDFLLQIRHQRI
| ... |    . . ||.   ||   .| |   |.|   .  .  | .  .. | |    .|.||.||| ...|    ...| ..|..   | ..|  |.
lsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrl

TLVQTKEQYIYIHKSLADHIQ-CGETSFAIEKAQYRIK
  ||   |. ...  ||.|.   | . .|| |     |
havqnlsqfsvvytllaehvldngicklaipkkpndek
subfamily_ptpA1_pd Subfamily ptpA1 1997-2081 9.9e-09 29.4 In-house 162-256 (418) alignment 
Range on Protein: 1997-2081
Range on HMM: 162-256/418.0
VHCWYTKRQLLITKD----DDSMSMAITHYQLTVWPDHGVPVDKIVM------ISFIDNIRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRM
|       . .||..     .  .  ||.||   |||| .|     .      |.  .|  .    .  |..|||||||||||||     |....
veviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2338-2400 3.4e-08 27.8 In-house 1-63 (69) alignment 
Range on Protein: 2338-2400
Range on HMM: 1-63/69.0
IVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
.|| |  | | .|||..   .. | |.| . |||  ..  |  || .|     ||. |. | |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
0048179 (Phosphotyrosine protein) phosphatases II 2309-2396 7.3e-08 27.8 In-house 55-139 (144) alignment 
Range on Protein: 2309-2396
Range on HMM: 55-139/144.0
WNINTNNKP----YLKPLFGILAKNqLEnGNRPIVVACNDGVGCSGTFLTAYsqieRAKTEGvSDIFQFIRKARSQRPGLVDCLERYIYCHE
...  .. |    .|  .. .. .  ||  ..|..| |. ||| .||. .||    . |..|  .... ..  ||.||| |   . .....|
lpwpDhgvpdllellleflefieea.le.eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2339-2400 1.3e-07 25.8 In-house 1-62 (69) alignment 
Range on Protein: 2339-2400
Range on HMM: 1-62/69.0
VVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
|| |. | | .|||..   .. | |.| . |||  ..  |  || .|   . |.. |. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
fn3 Fibronectin type III domain 1816-1891 1.4e-07 24.7 Pfam-A 3-82 (85) alignment 
Range on Protein: 1816-1891
Range on HMM: 3-82/85.0
PENVTAVWINSTTVKVTWLPLTlaEARGFITRYSV-YA--GNTG-IANVSNDSSI--AYIDSLNPMLQYSISVSASTKVGES
|||...  ..||.. ..| | .  . .| ||.|.| |.  |...   .......   . .  |.|  .|...| | ...||.
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngageg
subfamily_PTPDC1_pd Subfamily PTPDC1 1987-2114 1.4e-07 26.2 In-house 50-169 (182) alignment 
Range on Protein: 1987-2114
Range on HMM: 50-169/182.0
GIIIRTKTEEVHCWYTKRQLLITKDDDS-MSMAITHYQlTVWPDHGVP-VDKIVMISFIDNIRLTHppkGpPLVVHCSAGVGRTGTFIVIDTML-QRMKQ
 | ...| |  .| . ...   . | .. |   |..|.   |.|.||. ...|. |  . .  |..   |  . ||| || ||||  |    .  .|.. 
vinLqekgehasCGagleesGfsYdlealmeqgiyvyn.fgwkDygvasleriLdivkvvafalqe...g.kvavhChaGlGrtGvliacylvyakrlta

ENTLNiydfllQIRHQRITLVQTKEQYIYIH
|....       .|..|   .||.||   ..
ekaik......lvrskrpksiqtreqvelvk
0038934 (Phosphotyrosine protein) phosphatases II 2024-2074 1.6e-07 26.7 In-house 84-135 (194) alignment 
Range on Protein: 2024-2074
Range on HMM: 84-135/194.0
LTVWPDHGVPVDKIVMISFIDNIRLTHPP-KGPPLVVHCSAGVGRTGTFIVI
   .||.|.. .  .. .|.| .   .   .|   .||| ||.|||||... 
klpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
Ig_2 Immunoglobulin domain 772-857 2e-07 22.9 Pfam-A 11-75 (80) alignment 
Range on Protein: 772-857
Range on HMM: 11-75/80.0
LAITSSVMLNCTISlntgiG-PDTSFIshyWYQYNTDISDRSTPlmingdskslvI-IlniTNIQPSDAGEYQCRASIDGNdTIISNL
.   ..| |.|...     | |.....   ||. .. .| .              . |    |....|.| |.|||| ..   . || 
vtegenvtLtCqap.....gnptpkvq...wykdgeelsqsqna...........lfi...pnvsaedsGtYtCrasnseg.skqsns
Ig_2 Immunoglobulin domain 1215-1294 2.1e-07 22.9 Pfam-A 8-68 (80) alignment 
Range on Protein: 1215-1294
Range on HMM: 8-68/80.0
PdeQYYDVGSNVTLTCSVNypppdshidV----StslnISLFLGDdTLIRQSFTNIITyelNNLQLRDATLYTCSYfissDNDS
|  .... |.||||||...              .    ... ... ... ||  ....   .|... |.  |||..     |..
p..tvvtegenvtLtCqap.........gnptpk....vqwykdg.eelsqsqnalfi...pnvsaedsGtYtCra....snse
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2192-2258 2.2e-07 24.7 In-house 62-129 (347) alignment 
Range on Protein: 2192-2258
Range on HMM: 62-129/347.0
RVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCS-VIVLLHPVGTDEIPQFW
.    |  . ||||| .   .. . .|.|| || .|  ||| |..  . . |. .. |.  . | .| 
knsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaieefa
subfamily_hpo-7_pd Subfamily hpo-7 2226-2382 2.7e-07 24.7 In-house 45-207 (263) alignment 
Range on Protein: 2226-2382
Range on HMM: 45-207/263.0
NTQTDFWTMIHQQNCSVIVLLHPVG---TDEIPQFWPPQMGQAKKYQDLTVEHSLEKEenDYQIITLELKF--K-NESAHNVTLYYYKKWnINTNNKPYL
.|   |. .| |.. .|.|.|        ..  ...| .  . .|.....|  .  ..  |  . ||||    .     |.|. | || | |..|.    
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgW.iekndpela

KPLFGILaknQLENGNRPIVVACNDGVGCSGTFLTA---YS----QIERAKTEGVsDIFQFIRKARSQRP
.  . ||   ..  . ...|| |. |.| |  |  |   |     ... ..| .. |  ..... ||.|.
reilnil...kvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstvel.dylsLleelrssrk
Ig_2 Immunoglobulin domain 374-455 4.3e-07 21.9 Pfam-A 9-73 (80) alignment 
Range on Protein: 374-455
Range on HMM: 9-73/80.0
SSYIIGEQVLLQCSINltnaiG-PNISslnIKWFKSEEVIRDYimhdlalP-SsvfhssLTIPSVSFNDAGVYNCTASLTGS--QS
...  ||.| | |...     | |. .   ..| | .| .          .        | ||.|| .|.|.| |.||...   ||
tvvtegenvtLtCqap.....gnptpk...vqwykdgeelsqs.......qna......lfipnvsaedsGtYtCrasnsegskqs
I-set Immunoglobulin I-set domain 399-452 6.4e-07 21.1 Pfam-A 28-79 (90) alignment 
Range on Protein: 399-452
Range on HMM: 28-79/90.0
SSLNIKWFKSEEVIRDyiMHDLALPSSVFHSSLTIPSVSFNDAGVYNCTASLTG
  ....|.| .. ..    ... .  .  ...||| .|. .|.| |.|.|.   
pepsvsWakdgselks..sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsa
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2220-2394 8.7e-07 22.7 In-house 96-280 (302) alignment 
Range on Protein: 2220-2394
Range on HMM: 96-280/302.0
TQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPPQMGQAKKYQDLTV-----EHSLEK--EENDYQIITLELK---FKNESAHNVTLYYY
  .| ..|.  .|..|.| | ...| |  .  ||   . ...  ..|.  |..  ||     .. ||.  . ..... |.|.|    |..  . | . ..
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

KKWNINTNNKPYlKPLFGILakNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYC
  |      |   .. . ||  .  |   . ..| |  ||| .||...    |.  ... |.|. . .   |. | | |   .. || 
sawpdhGapkea.ytaldil..kfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2162-2247 1e-06 22.7 In-house 29-114 (312) alignment 
Range on Protein: 2162-2247
Range on HMM: 29-114/312.0
SDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLH
 .  |   |.  .  .. ||.     ..  |  |   || || | .|      . |..|| ||.|| | || .     .. |.|| 
gnivsdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc
subfamily_egg_pd Subfamily egg 1963-2118 1.2e-06 22.4 In-house 116-267 (307) alignment 
Range on Protein: 1963-2118
Range on HMM: 116-267/307.0
ITTDSNKCAQYWPEKVNETHKL-DDGIIIRTK--TEEVHCWYTKRQLL-ITKDddSMSMAITHYQLTVWPDHgvpvDkivMISFIDNIRLTHPpKGPPLV
 . .|..|  |||   ... ..   .. | .    ..    ..  .|  .  |     . . |.|  |        |   . | .  .|.       | |
srkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdvnnss....d...vysplrvlrklrn.lskpvv

VHCSAGVGRTGTFIVIDTMLQRMKQENTL--NIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
|..  || ...|.. |.. |  . .  .    .      .| .|   |..  .|..... ..
vqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
ig Immunoglobulin domain 1223-1285 1.6e-06 19.4 Pfam-A 1-63 (64) alignment 
Range on Protein: 1223-1285
Range on HMM: 1-63/64.0
GSNVTLTCSVnypppdshIDVSTSLNISLFLGDDTLIRQSFTNIIT--------YELNNLQLRDATLYTCS
||.|||||||         . . | ..|.. ....|.  . |.  .        ...||..  |.. |||.
GssvtLtCsv........ssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCv
Ig_2 Immunoglobulin domain 576-653 1.7e-06 20.0 Pfam-A 14-74 (80) alignment 
Range on Protein: 576-653
Range on HMM: 14-74/80.0
SSTVNIECTIIlntpvgpGI-QPNVTWYYDATDITlSGsllRNNdivfistLTIDSIQVSDAGVYHCNAGIDSNVTTSN
...|.. |..        |  .|.|.|| | . .. ..   .|.       | | .....|.|.|.| |  ..  ..||
genvtLtCqap.......gnptpkvqwykdgeels.qs...qna.......lfipnvsaedsGtYtCrasnsegskqsn
Ig_3 Immunoglobulin domain 368-449 2e-06 19.9 Pfam-A 4-74 (75) alignment 
Range on Protein: 368-449
Range on HMM: 4-74/75.0
VSIKFNSSYIIGEQVLLQCSINLTNAigpnisSLNIKWFkseevIRDYIMHDLALPSSVFHSSLTIPSVSFNDAGVYNCTAS
.|...... . |. | |.||.  . .      . .| |      |      .    ||  .|.|||.||...| |.| |.||
isvspsptvtsggnvtLtCsaeggpp......pptisWy.....ietppelqgsegssssestLtissvtsedsGtYtCvas
Ig_3 Immunoglobulin domain 285-352 2.1e-06 19.9 Pfam-A 4-75 (75) alignment 
Range on Protein: 285-352
Range on HMM: 4-75/75.0
VTISGNYTSLRVGSsTDIECETVPSIPNAVIKWQ------DVSSFNSYSYENVLTIDPVLlSNDNKTFTCVVSS
...| . |   .|.   . |... . |.. | |.      . .| .|.|.|..||| .|  |.|. |.|||.|.
isvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvt.sedsGtYtCvasN
PTEN_1 1974-2072 2.4e-06 22.5 In-house 44-148 (196) alignment 
Range on Protein: 1974-2072
Range on HMM: 44-148/196.0
WPEKVNETHKLDD-GIIIRTKTEEVHCWYTKRQLLIT-----KDDDSMSMAITHYQLTvWPDHGVPVDKIVM--ISFIDNIRLTHPPkGPPLVVHCSAGV
..|.... . .|      . | . ......      .      ... . . ......  ..|||.|    ..  .  ... .| .|. |   .||| ||.
ideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfp.ieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGl

GRTGTFI
||.|| .
gRsGtvv
PTPlike_phytase Inositol hexakisphosphate 1949-2078 2.6e-06 22.1 Pfam-A 32-148 (149) alignment 
Range on Protein: 1949-2078
Range on HMM: 32-148/149.0
KTEEAVELYSYITKITTDSNKCAQYWPEKVNETHKLDDGIiiRTKTEEV-HcwytkrqlLITKDDDSMSMAITHYQLTVwPDHGVPVDKIVMiSFIDNIR
. .|| ||.   ... .| .| |.    ..   .. ..|.    ...|| .         ... . . .. .. . ... .|.  | .. |  .|.. |.
sgieaeeledlekrlkedvlkeaeeyegrilvhreteegv..qktltevte........evyeeelaegfgvkYvRipi.tdeqapeeedvD.afvrlik

LThpPKGPPLVVHCSAGVGRTGTFIVIDTML
 .  |. . ||..|.|| ||| |..|| ..|
sl..prdtalvfnCqaGrgRTTtamviadLl
PTPlike_phytase Inositol hexakisphosphate 1949-2078 2.6e-06 22.1 In-house 32-148 (149) alignment 
Range on Protein: 1949-2078
Range on HMM: 32-148/149.0
KTEEAVELYSYITKITTDSNKCAQYWPEKVNETHKLDDGIiiRTKTEEV-HcwytkrqlLITKDDDSMSMAITHYQLTVwPDHGVPVDKIVMiSFIDNIR
. .|| ||.   ... .| .| |.    ..   .. ..|.    ...|| .         ... . . .. .. . ... .|.  | .. |  .|.. |.
sgieaeeledlekrlkedvlkeaeeyegrilvhreteegv..qktltevte........evyeeelaegfgvkYvRipi.tdeqapeeedvD.afvrlik

LThpPKGPPLVVHCSAGVGRTGTFIVIDTML
 .  |. . ||..|.|| ||| |..|| ..|
sl..prdtalvfnCqaGrgRTTtamviadLl
fn3 Fibronectin type III domain 1423-1510 2.7e-06 20.6 Pfam-A 3-80 (85) alignment 
Range on Protein: 1423-1510
Range on HMM: 3-80/85.0
PINMTSVVLNTTSVRIEWVVT-SVTYSPEIYTVHYESLSCYHngsfsingstsVEVFTQESNTPYSLTIDGLKPGIKYTYYIASKNTEG
| |..    ..||....|    .     . |.|.|.. .  .           ...  . ..| .|.|. ||||| .|.. ... |..|
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...........ewkeftvprtttsvtltgLkpgteYefrVqavngag
Ig_3 Immunoglobulin domain 770-846 3.8e-06 19.0 Pfam-A 17-74 (75) alignment 
Range on Protein: 770-846
Range on HMM: 17-74/75.0
LllaitssVMLNCTISLNTGigpdtsFISHYWYqyntdiSDRSTPLMINGDSKSLVIILNITNIQPSDAGEYQCRAS
        | |.|..  . .        ...||       . .  |  ...|.|   .|.|.. ...| | |.| ||
n.......vtLtCsaeggpp......pptisWy......ietppelqgsegssssestLtissvtsedsGtYtCvas
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2335-2397 8e-06 19.9 In-house 228-290 (297) alignment 
Range on Protein: 2335-2397
Range on HMM: 228-290/297.0
NRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHEL
| ...| |  ||| ||  . .   ... . . . |.  .... |.||. ||  ||.. .....
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_PTEN_pd Subfamily PTEN 2057-2114 8.6e-06 20.8 In-house 117-175 (184) alignment 
Range on Protein: 2057-2114
Range on HMM: 117-175/184.0
LVVHCSAGVGRTGTFIVIdTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYI--H
 |||| || ||||. ||   .|.... |.. .. ..  ..| .  . |.   |  |.  .
vvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYy