Gene PTPRD-6 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP117_AA protein Get Run
AqueP117_AA_1948-2122 phosphatase_domain Get Run
AqueP117_AA_2133-2407 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2144-2410 3.7e-170 558.8 In-house 1-267 (267) alignment
Range on Protein: 2144-2410
Range on HMM: 1-267/267.0
NEDEECEFQKEFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVI
|||||||..|||||.|..|||.||||.|||..||||||.|.||||..||||||..|..|||||.||||||.|.|||||.||.||.|||.|.||.|...||
nedeeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VLLHPVGTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESAHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLENGNRPIVVACN
|||..|.||.|..||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||.
vlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacs

DGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGMLQHEE
||||.|||||...||.||||||||||||.|.||.||||.||||..|||||.||||.|||||.|..||
dGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlkeee

0050432 (Phosphotyrosine protein) phosphatases II 2123-2406 1.1e-64 214.1 In-house 14-303 (308) alignment
Range on Protein: 2123-2406
Range on HMM: 14-303/308.0
CGETSFAIEKAQYRIKELRK--KNEDEECEFQKEFELLKELSDtTSTISCSIAMDNQERNRFDYNLPYNHTRVILrDTENDYINASWVEGY--KTGNWFI
...||.  .. ......| |  .. ..   ...||| | .. .   ..|..   .|...||.   ||| |.||.| | ..||||||.| ||  |  . ||
frdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfI

VTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDEI---PQFWPPQMG-QAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNiNT
.|| ||.||  ||| |...||..||| |     ...   .|.||. .| . ..| ..||..  |....|| . ||||.. ...  . || ..|. |  . 
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp.dh

NNKPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGML
.  |....|. .| . .  ... |||| |..||| .|||....  .|. ..||  |.|. ..| |.|||| |  .| |......|.||.. .|
gvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0051299 (Phosphotyrosine protein) phosphatases II 2138-2402 1.6e-63 210.2 In-house 12-286 (288) alignment
Range on Protein: 2138-2402
Range on HMM: 12-286/288.0
KELRKKNEDEECEFQKEFELLKELSDTtSTISCSIAMDNQERNRFDYNLPYNHTRVILRD----TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWT
| ..|.  .  . ...||| | .|  .  |.|...   |.|.||.   |||.|.||.|..     ..||||||...||.... ||.|| ||.||  ||| 
klvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWr

MIHQQNCSVIVLLHPVGTDE---IPQFWPPqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF-----KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGI
|...||..||| | ..  ..    .|.||.  |. ..| |.||.   |....|| . |||..      ...  ..|| ..|..|  . .  .....|. .
mvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdspellldf

LAKNQLE--NGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
| . .    .|. |.|| |..||| .|||....  .|. ..||. |....... |.||||.|  .| |....|.|.||.
lrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0047943 (Phosphotyrosine protein) phosphatases II 2143-2402 3.4e-62 205.7 In-house 6-272 (273) alignment
Range on Protein: 2143-2402
Range on HMM: 6-272/273.0
KNEDEECEFQKEFELLKELSDtTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSV
.. .    ...|||||..| .   |.|...  .|...||.   |||.|.||.| | ..||||||.|.||.... ||.|| ||.||  ||| |...||..|
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVLLHPVGTDE---IPQFWPPQMGQ-AKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGILA----KNQLEN
|| | ..  ..    .|.||. .|.  ..| ..||..  |....|| . ||||.. ...  . || ..|..|  . .  |.|..|. ..     ...  .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp.dhgvppslesllefielvrkalealp

GNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
.| |.|| |..||| .|||....  ... ..||  |... ... |||||| |  .| |....|.|.||.
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_PTPRD_pd Subfamily PTPRD 1966-2160 4.4e-62 205.5 In-house 129-321 (564) alignment
Range on Protein: 1966-2160
Range on HMM: 129-321/564.0
DSNKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGV
. .||..||||| .||.   .....  . ||    |. |.. ..| ..| |. ..... | |||||||     ....|...| ...|.  |.||||||||
gkvkchkYWPekgtety...geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGV

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKNEDEE-CEFQKEFELLKE
|||||||||| ||.|.|.|.|..|| .. ..|.|| ..|||.||||.||. ... ..||.|.  .|. . ....|....||.|  ....||. |. 
GRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLat

0046845 (Phosphotyrosine protein) phosphatases II 2151-2404 8.6e-62 204.4 In-house 2-276 (284) alignment
Range on Protein: 2151-2404
Range on HMM: 2-276/284.0
FQKEFELLKELSDTTS-TISCSIAMDNQERNRFDYNLPYNHTRVILRD-----TENDYINASWVEGY-----KTGNWFIVTQIPLQNTQTDFWTMIHQQN
...||| |  |  . . ..|....  |...||.   |||.|.||.|.       ..||||||.|.||     .. . ||.|| ||.||  ||| |...||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CSVIVLLHPVGTDE---IPQFWPPQmGQAKKYQDLTVEHSLEKEENDYQIITLELKFK--NESAHNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLE--
..||| | .   ..    .|.||.  |. ..| |.||.   |....|| ..||||...  ..  . || ..|..|  . .  |....|. .| . .    
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp.dhgvppspedlleflrlvrelle

--NGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEG---VSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEG
  .|. |||| | .||| .|||....  .|. ..||   . |... ... |.|||| |  || |....|.|.||.  
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

0036941 (Phosphotyrosine protein) phosphatases II 2146-2405 4.1e-61 202.2 In-house 10-280 (297) alignment
Range on Protein: 2146-2405
Range on HMM: 10-280/297.0
DEECEFQKEFELLKELSDtTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVL
.    ..|||| | .|     ..|...  .|.|.||.   |||.||||.| | ..||||||.|.||. .. ||.|| ||.||  ||| |...||..||| 
lflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvm

LHPV---GTDEIPQFWPPQMGQAKKYQDLTVEHSLEKE--ENDYQIITLELKF-KNESAHNVTLYYYKKWNIN---TNNKPYLKPLFGILAKNQLENGNR
| ..   |    .|.||. .|. ..| |.||.   ...  ..|| . |||... .|.  . || ..|..|  .   .. ...|. .  .. ...| ... 
ltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

PIVVACNDGVGCSGTFLTAYSQIERAK---TEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGM
|..| |..||| ||||..|.  ... .   .||  ||.....| |.|||| |  || |....|.| |.    
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2136-2402 4.9e-60 198.3 In-house 13-290 (298) alignment
Range on Protein: 2136-2402
Range on HMM: 13-290/298.0
RIKELRK-KNEDEECEFQKEFELLKELSD--TTSTISCSIAMDNQERNRFDYNLPYNHTRVILRD----TENDYINASWVEGYKTGNWFIVTQIPLQNTQ
 ...| . |.. .   ...||. |.. |.   . . . . . .|...||.   ......||.|..     | ||||||....||  | ||.|| ||..| 
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

TDFWTMIHQQNCSVIVLLHPVGT---DEIPQFWPPQmgQAKKYQDLTVEHSLEKEENDYQIITLEL-KFKNESAHNVTLYYYKKWNINTNNKPYlKPLFG
.||| |. ... ..||.|...      .....|| .  ....| ..||.   ..|  |. . .|.. | |.|. ..|    . .|  ..  . . . ...
edFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpena.tsvld

---ILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
      ..| ..||.|..| | .||| ||||   .| .||.|.| | |.|| ..  | .|||.|.  |.|....|.  |. 
llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal

DSPc_SM00195 2151-2402 1.4e-59 196.9 In-house 2-262 (263) alignment
Range on Protein: 2151-2402
Range on HMM: 2-262/263.0
FQKEFELLKELSDTTsTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLL
...||| |.|   .. ......   |...||.   |||.||||.| ..|    .|||||....|..  . .|.|| ||..|  |||.|. ......|| |
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

HPVGT---DEIPQFWPPQMGQAKKYQDLTVEHSLEKEEN-DYQIITLELKFKN-ESAHNVTLYYYKKWNINtNNKPYLKPLFGILAKNQLENG--NRPIV
    .    .. ..|| ..|. .......|.   ..... .... ||||.... | ...|| | ||.|. . .     |... .| . . ..   . |||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkkskstssgpiv

VACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
| | .||| .|||.|. . ... ..|   |||. ... |.||||.|. || |....| . ||.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 2151-2402 1.4e-59 196.9 In-house 2-262 (263) alignment
Range on Protein: 2151-2402
Range on HMM: 2-262/263.0
FQKEFELLKELSDTTsTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLL
...||| |.|   .. ......   |...||.   |||.||||.| ..|    .|||||....|..  . .|.|| ||..|  |||.|. ......|| |
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

HPVGT---DEIPQFWPPQMGQAKKYQDLTVEHSLEKEEN-DYQIITLELKFKN-ESAHNVTLYYYKKWNINtNNKPYLKPLFGILAKNQLENG--NRPIV
    .    .. ..|| ..|. .......|.   ..... .... ||||.... | ...|| | ||.|. . .     |... .| . . ..   . |||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdstksvlellravkkskstssgpiv

VACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
| | .||| .|||.|. . ... ..|   |||. ... |.||||.|. || |....| . ||.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPRD_pd Subfamily PTPRD 2146-2403 1.5e-59 197.1 In-house 20-282 (564) alignment
Range on Protein: 2146-2403
Range on HMM: 20-282/564.0
DEECEFQKEFELLKELsdTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCS
... .|..|.. ..|   ...|.. . .  |...||..  ..|.|.||.|. .|     ||||||...||.. . .| || ||..|  ||| |. .||.|
nsdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnss

VIVLLHP---VGTDEIPQFWPPQmGqAKKYQDLTVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYKKWNINTNNKpYLKPLFGILA---KNQlENG
.||.|      |.... ..|| . |  ..|..|||. . |.| .||.| |..|| |. .....|. ... .|  .   . . ..|  ..    . . |..
tiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpe.satslLdlirkvraln.epd

NRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
. |||| |. ||| .|||..  . .||.|.|.. ||.|.... |.||. .|.  | ||..|| . |. .
agPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala

0040438 (Phosphotyrosine protein) phosphatases II 2149-2403 3.4e-59 196.0 In-house 18-277 (317) alignment
Range on Protein: 2149-2403
Range on HMM: 18-277/317.0
CEFQKEFELLKELSDTtsTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIV
  ...||| | .|.    |.|...  .|...||.   ||| |.||.| ...    .||||||.|.|.. .. ||.|| ||.||  ||| |...|...|||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

LLHPVGTDE---IPQFWPPqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLE--NGNRPI
 | .   ..     |.||   |. ..| |.||..  |.|...... |||..  ...  . || ..|. |    .  |....|. .| . .    ... |.
mLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp.dhgvppspdllldfleavrealedpggpv

VVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
.| |..||| .|||..||  .|. ..||  |... ... |.|||| |  .| |......|.||  
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk

0045450 (Phosphotyrosine protein) phosphatases II 2131-2401 3.6e-57 189.8 In-house 9-303 (307) alignment
Range on Protein: 2131-2401
Range on HMM: 9-303/307.0
EKAQYRIKELRKKNEDEECEFQKEFELLKELSDT-TSTISCSIAMDNQERNRFDYNLPYNHTRVILRD-----TENDYINASWV--------EGYKTGNW
..| . .......  |    ..|||| |... ..   ..|..    |...||.   |||.||||.| .      ..||||||.|        .||. .. 
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

FIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDEI---PQFWPPQmGQAKKYQDLTVEHSLEKEENDYQIITLELKF--KNESAHNVTLYYYKKWNi
||.|| ||..|  ||| |...|...||| | .   ..    .|.||   |. . | ..||.   |.....|.. |||..   ...  . || ..|..|  
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp.

NTNNKPYLKPLFGILAKNQL--E--NGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGV---SDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
...  |....|. .. . .   |  ... |..| |..||| .|||..||  ... ..||.    |... ... |.|||| |  .| |....|.|.|.
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0039614 (Phosphotyrosine protein) phosphatases II 2143-2403 6.8e-56 185.3 In-house 26-290 (297) alignment
Range on Protein: 2143-2403
Range on HMM: 26-290/297.0
KNEDEECEFQKEFELLKELSDTtstISCSIAMDNQERNRFDYNLPYNHTRVILRDTE-----NDYINASWVEGYKT-GNWFIVTQIPLQNTQTDFWTMIH
.. ..   ...||| |..| .    .|..    |...||.   |||.|.||.| . .     .||||||.|.||.  .. ||.|| ||..|  ||| |..
ekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

QQNCSVIVLLHPVGTDE--IPQFWPPQMGqakKYQDLTVEHSLEKEENDYQIITLELKFKNESaHNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLEN-
.|...||| | .   ..   .|.||. .|   .| |.||.   ......| . |||.. ..|| . || . | .|    .  |.|. |. .| . .  . 
eqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges.rtvthfqytgwp.dhgvppslellleflelvreala

---GNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
   ...|..| |..||| .|||..||  .|. ..||  |... ... |.|||| |  .. |......|.|.  
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1964-2142 8e-56 184.4 In-house 125-304 (305) alignment
Range on Protein: 1964-2142
Range on HMM: 125-304/305.0
TTDSNKCAQYWPEKVNETHKLdDGIIIRTKTEEVHCWYTKRQLLITK-DDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPK-GPPLVVHC
  . .|| |||||...|.... . ...  | |.    |..|.| |.. |.|. | ....|||| |||||||     ..|.|.... ..    | ||.|||
eggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhC

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRK
||||||||.||..| .|.|.|.|....... | |.|..|. .|||..|| ..|  |.. |.||.||  ..  . |.. |.|
sagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklkk

0043336 (Phosphotyrosine protein) phosphatases II 2143-2401 1e-55 184.5 In-house 14-276 (278) alignment
Range on Protein: 2143-2401
Range on HMM: 14-276/278.0
KNEDEECEFQKEFELLKELSDttSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQ
.. ..   ...||| | .      |.|... ..|...||.   |||.|.||.| ...    .||||||.|.||. .. ||.|| ||..|  ||| |....
lllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel

NCSVIVLLHPVGTDE---IPQFWPpqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNinTNNKP-YLKPLFGILA--KNQL
....|| | .   ..     |.||   |. ..| |.||.   |....|| ..|||..  ..   . || |.|..|    .. |  |..|. .|   ...|
gvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavreal

ENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
|. | |..| |..||| .|||...|  .|....||  |... ... |.|||| |  .. |....|.|.||
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2143-2403 1.6e-55 183.2 In-house 14-279 (287) alignment
Range on Protein: 2143-2403
Range on HMM: 14-279/287.0
KNEDEECEFQKEFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSV
 ..  . .|.. | .|......   .  .|| .|...||.   |...  ||.|.....|||||....|||  . ||... |. ||  .|| .|...| ..
ghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvta

IVLLHP---VGTDEIPQFWPPQMGqaKKYQDLTVEHSLEKEENDYQIITLELKFKN--ESAHNVTLYYYKKWNINTNNKPYLKPL--FGILAKNQLENGN
||.|       ..   |.|| .      . . ..|   |. ...| . .||.| ||  .. ..|. | . .|. . . . .   |  .    |.|  .||
ivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgn

RPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 .||| | |.|| |..|. |   |...||||| |.|| ... | |.|| |   |.|..  ... || .
tsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2145-2403 4.8e-55 181.5 In-house 16-284 (290) alignment
Range on Protein: 2145-2403
Range on HMM: 16-284/290.0
EDEECEFQKEFELLKElSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILR------DTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQ
   .  |...|. |.  ..   |.   .. .|...|||.  ..|.  |..||      | .|.||||....|||  . .|.|| |..||  ||| .| |.
akgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqe

NCSVIVLLHPVG---TDEIPQFWPPQmgQAKKYQDLTVEHSLEKEENDYQIITLELKFKNE--SAHNVTLYYYKKWNINT--NNKPYLKPLFGILAKNQL
....||.|  .    ...  |.|| .  ..|.|.  ... . |.. |.| ...||.| ||.  ....|| |  . |. .   .|.     ..    |.| 
kvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqr

ENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 .||..||| | |.|| |..|..|.  |...||||| |.|| ... |.|.||.|   ..| . .... .| .
krgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

Y_phosphatase Protein-tyrosine phosphatase 2176-2399 8.2e-55 181.1 Pfam-A 1-234 (235) alignment
Range on Protein: 2176-2399
Range on HMM: 1-234/235.0
NQERNRFDYNLPYNHTRVIL--RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGT---DEIPQFWPPQMGQAKKYQD
|...||.   |||..||| |  .....|||||..|.|||. . ||.|| ||..|  ||| |. |....|||.|  .      ...|.|| .... ..|.|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LTVEHS-LEK-EENDYQIITLELKFKNESA--HNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLEN--GNRPIVVACNDGVGCSGTFLTAYSQIERAKT
..||    || .|..|.. .|||| |.|.   . |. . |..|. . . .   |.|. .. | . ..   . |.|| | .||| .|||...   .|....
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLC
|.  |..|.... |.||||.|. || ||...... 
eeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 2176-2399 8.2e-55 181.1 In-house 1-234 (235) alignment
Range on Protein: 2176-2399
Range on HMM: 1-234/235.0
NQERNRFDYNLPYNHTRVIL--RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGT---DEIPQFWPPQMGQAKKYQD
|...||.   |||..||| |  .....|||||..|.|||. . ||.|| ||..|  ||| |. |....|||.|  .      ...|.|| .... ..|.|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LTVEHS-LEK-EENDYQIITLELKFKNESA--HNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLEN--GNRPIVVACNDGVGCSGTFLTAYSQIERAKT
..||    || .|..|.. .|||| |.|.   . |. . |..|. . . .   |.|. .. | . ..   . |.|| | .||| .|||...   .|....
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLC
|.  |..|.... |.||||.|. || ||...... 
eeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2146-2403 2.1e-54 179.7 In-house 20-284 (319) alignment
Range on Protein: 2146-2403
Range on HMM: 20-284/319.0
DEECEFQKEFELLKELSDTtsTISCSIAMDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCS
  |  ..|||.|||| ...  |.. .   .|...||.   |.|..|||.| .     . ||||||...||.  . || || ||.||  ||| |. ....|
tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

VIVLLHPVGTD---EIPQFWPpqMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESA--HNVTLYYYKKWNIN---TNNKpYLKPLFGILAKNQLEN
..|.|  .      .. ..||    . ..|  |.|.   |.| .|| |  |.|. |..     .|. ..|..|  .   .. .  |  |.. ..| . ..
ivvmltklveklkvklkkywp..eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat.slldllkrirksrekt

GNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 ..|||| | .|||  |||..    .|| | ||| |.|..... | ||. .|.  | |....| | |..|
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2139-2401 5.4e-53 174.9 In-house 11-278 (288) alignment
Range on Protein: 2139-2401
Range on HMM: 11-278/288.0
ELRKKNEDEECEFQKEFELLKELSDTTSTISCSIAmDNQERNRFDYNLPYNHTRVILRD----TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTM
   ||. ... .|..|.. | .|  | |.   . |  |...||.   |||...|| |..    ...||||||...|.|  . .| || ||..|  ||| .
kvakksarnrtgfseeynsLaalektksvtagrla.vnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IHQQNCSVIVLLHPV---GTDEIPQFWPpQMGQAKKYQDLTVEHSLEKEENDYQIITLELKfKNESAHNVTLYYYKKWNINTnNKPYLKPLFGILAKNQL
..... | || |  .   |  .  ..|| . .. |.| ..||.   .||..|.   .|.|. |...  ..| | |. |  .       .||...| . . 
vyenktstivmltelveggktkCeeYWP.dadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhg.vPeskapllellrqvkv

ENG--NRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
 |     ||.| | .||| .|||...   |.. ..| . |.. .. | | ||. ||. |..|....| | . 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2148-2403 6.7e-53 174.8 In-house 19-281 (318) alignment
Range on Protein: 2148-2403
Range on HMM: 19-281/318.0
ECEFQKEFELLKELSDTTSTISCsIAMDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVI
| ....|.| |.  ..|....   .   |. .||.   |.|.|||| |...    . |||||....||.  . .| .| || .| .||| |. .||..||
elllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavi

VLLHP---VGTDEIPQFWPPQmgQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESA-HNVTLYYYKKWNINT--NNKPYLKPLFGILAKNQLENGNRP
|.|      | . . ..|| .  ....|..|.|| . |.| .|| . ..... ..|..  .|  | | .|  .   ..   |  | .   | |...|..|
vmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

IVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
||| |  |||  |.|..  ...||.| |.. |.||.... |.||. .|   ..|..... | |. .
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2147-2403 6.1e-51 168.4 In-house 20-284 (305) alignment
Range on Protein: 2147-2403
Range on HMM: 20-284/305.0
EECEFQKEFELLKELsDTTSTISCSiaMDNQERNRFDYNLPYNHTRVILRDT--E--NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSV
.. ........| |. ...  . ..    |...||.  . .... |.||. .  .  .||||||.|.|||  . .||.| ||.|| .||| .| .   |.
sdkgleaqykslyee.eesidvgkk..eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

IVLLH---PVGTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKF--KNESAHNVTLYYYKKWNINT--NNKPYLKPLFGILAKNQLENGN
||.|      | |   |.|| .... |......|| . ||. .|| .  |.. .  ...  ..|. |   .|  .   .    |  |.  . |.| .. .
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

RPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 |..| |..||| .|.|..   ..||.|.|.| |.|. ....||.|...|  |..| ..|. | |. .
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2174-2403 8.4e-51 167.6 In-house 7-243 (250) alignment
Range on Protein: 2174-2403
Range on HMM: 7-243/250.0
MDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGT--DEIPQFWPpqMGQAKK
..|.|.||.   ......||.|  .    | ||||||...||.  . ||.|| |||.|  ||| |. ... ..||.|  .     ...|.||  . .|.|
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywP..vekaek

YQDLTVEHSLEKEENDYQIITLELKFKNESAH-NVTLYYYKKWNINTN---NKPYLKPLFGIlAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAK
| |.||.   ..|  ||.. .| |  .... .  |  . .  |   .     .  |. |  .  ..| . ||.|..| |  ||| ||.|.. .. .||.|
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkv.qasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

TEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
.| | |.|..|.. | .||. |. ||.|....|.. .. .
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

0040439 (Phosphotyrosine protein) phosphatases II 2167-2401 1e-49 164.8 In-house 2-245 (249) alignment
Range on Protein: 2167-2401
Range on HMM: 2-245/249.0
TISCSIAMDNQERNRFDYNLPYNHTRVILRDTEN----DYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTD---EIPQFWP
..|... . |...||.   |||.|.||.| ....    ||||||...||. .. ||.|| ||..|  ||| |.......||| | .          |.||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

PqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGILAKNQLEN----GNRPIVVACNDGVGCSGTFLT
.  |. ..| |.||.   .....|| . ||||.. .. . . |. ..| .|   ..  |....|. .. . .  .     . |..| |..||| .|||..
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

AYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
||  .|. ..|.  |... ... |||||| |  .| |....|.|.|.
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

0050432 (Phosphotyrosine protein) phosphatases II 1966-2126 5.6e-49 162.5 In-house 146-304 (308) alignment
Range on Protein: 1966-2126
Range on HMM: 146-304/308.0
DSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppKGPPLVVHCSAGV
. .|||||||...... .  ... .... |||. .||.|.| .|. .|. |  .||.. | ||||||| .   ...|.. .| ..  .|.| ||||||||
grekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGv

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGET
|||||||..|..|.....|....... . ..|.||   |||.|||..... |...... .|
GRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt

subfamily_Ptp69D_pd Subfamily Ptp69D 2139-2403 8.9e-49 161.3 In-house 12-287 (307) alignment
Range on Protein: 2139-2403
Range on HMM: 12-287/307.0
ELRKKNEDEECEFQKEFELLKELsDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTM
.|.....| .  ..||.| |..   .  . . |   .|. .||..   ....|||.|. .    . ||||||...|||  . ||. | |...|  ||| |
alksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRm

IHQQNCSVIVLLHPVGTD---EIPQFWPPQmgQAKKYQDLTVEHSLEKEENDYQIITLELKFKN------ESAHNVTLYYYKKWNiNTNNKPYLKPLFGI
| .|.  .||.|  ..     .....|| .  . ..|.|. |.   |.. .|| | .|..  |.      |  ..|. | |. |. ...     . |. .
iaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllkl

LAKN--QLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
. .     .. . |||| |. ||| ||.|..  | ... |.|   |||..... ||||. ||. || |....  | .| .
ieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

0042113 (Phosphotyrosine protein) phosphatases II 2169-2402 1.3e-48 161.0 In-house 2-243 (245) alignment
Range on Protein: 2169-2402
Range on HMM: 2-243/245.0
SCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPPq
|... . |...||.   |||.||||.| ...    .||||||.| ||.  . ||.|| ||..|  ||| |........|| | .   ..    .|.||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

mGQAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWNINTNN--KPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQ
 |. ..| |.||.   |. ..|| . |||..  ..   ..|. |.|  |  ..      .|  .. .. | . |..| |..| |..||| .|||..||  
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

IERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
.|....|.  .... ... |||||| |  .. |....|.|.|. 
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

0045098 (Phosphotyrosine protein) phosphatases II 2151-2405 1.8e-48 160.7 In-house 9-275 (278) alignment
Range on Protein: 2151-2405
Range on HMM: 9-275/278.0
FQKEFELLKELSDTtSTISCSIAMDNQERNRFDYNLPYNHTRVIlrdtenDYINASWVEGYktGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV-
.. ||| |  |..  |.|....  .|...||.   |||.|.||.      ||||||...||  .. ||.|| ||..|  ||| |.......||| | .. 
lllefefllllgip.seitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

--GTDEIPQFWPPqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF-----KNESAHNVTLYYYKKWNINTNNKPY-LKPLFGILA----KNQ-------
  |    .|.||.  |. . | |.||.   |.. .|| ..||..       ..   ..|| ..|. |  ..      ||... .|      ..       
elgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

----LENGNRPIVVACNDGVGCSGTFLTAYSQIERAktEGVSDIFQFIRKARSQRPG-LVDCLERYIYCHELLCEYAEGM
    |.... |..| |. ||| .||.  ||  .|.   ||. |... ... ||||||  |  || |....|.|.|. . .
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

0040438 (Phosphotyrosine protein) phosphatases II 1966-2140 4.2e-48 159.6 In-house 124-295 (317) alignment
Range on Protein: 1966-2140
Range on HMM: 124-295/317.0
DSNKCAQYWPEkvNETHKLdDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGV
. .|||||||.  .|| .  ........ ||..  .| |.| .....|| |  .||.. | ||||||| .   ...|.. .|   ...| |..|||||||
grekcaqYwpl..getlty.gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGv

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKEL
|||||||....||.....|....... . ..|.||   ||| |||..... |........|.  . .  .....|
gRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkl

subfamily_PTPRB_pd Subfamily PTPRB 2138-2403 4.9e-48 158.6 In-house 14-286 (293) alignment
Range on Protein: 2138-2403
Range on HMM: 14-286/293.0
KELRKKNEDEECEFQKEFELLKELSDTTStISCSIAMDNQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWT
. ..|...|....|..|.| ||..  ... .... .. |...||.   |||.|.|| |     ....|||||....||.. . ||.|| || .|  ||| 
ehvkkmkadsdlrfseeyeelkavgkdqa.vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWr

MIHQQNCSVIVLLHPV---GTDEIPQFWPPQMgQAKKYQDLTVEHSLEKEENDYQIITLELKFkNESAHNVTLYYYKKWN---INTNNKPYLKPLFGILA
|......|.||.|  .   |     ..|| .  ..  | |..|.   |.| .|. | .|...  ... ..|. | .. |    .  . |. |. .  .  
mvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvre

KNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
. . .. .||||| |  ||| .|||..    ... ..| . ||| .. . |..|  ||   ..||. |. . .. .
aiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2132-2400 8e-48 158.4 In-house 17-289 (319) alignment
Range on Protein: 2132-2400
Range on HMM: 17-289/319.0
KAQYRIKELRKKNEDEECEFQKEFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNT
.|.|. .  ... .|.  ... ||  . .|.   .. . .   .|...||.   |......| |. ..     ||||||.|.||.  . .| .| ||.||
payyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldnt

QTDFWTMIHQQNCSVIVLLHpvgTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEEndYQIITLELKF--KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGI
  ||| || ..||| ||||     |   |.|| .. . ..  .. |.   | .|  | .  .||    |..   ..| .... |  .     |  .|. .
ladfWrmiweyncstivllt...kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwp.dvGvpdypsdlmrl

LAK----NQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
. |    .. ||....||| |  ||| .|....    ..| | |   |...|.|  | ||. ||. | .| ...  | |
vkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1968-2146 1e-47 157.8 In-house 129-305 (318) alignment
Range on Protein: 1968-2146
Range on HMM: 129-305/318.0
NKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTH-PPKGPPLVVHCSAGVG
.|...|||.|  ...   . . .  | |     |. |.. .|... . |  .  |. | |||.||| .   ..... ... .. ...  |.|||||||||
akvhryWPskgsrsy...gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvG

RTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKNED
|||.||..|..|.|.|.|........  |.|.||  .|||..||..|.. | . ...|.|    .. . ||.|||... .
rtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpe

subfamily_PTPN23_pd Subfamily PTPN23 2137-2407 2.1e-47 156.3 In-house 3-285 (288) alignment
Range on Protein: 2137-2407
Range on HMM: 3-285/288.0
IKELRKKNEDEECEFQKEFELLKELSD-TTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTG-NWFIVTQIPLQNTQTDFWTM
..||..|  |.. ...|.|..|..  |  .   |..||  . |.||.   |||.|.|| ||....||||||.|..  .|   ||.|| |||.|  ||| |
veelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlm

IHQQNCSVIVLLHPVGTDEI---PQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESA-HNVTLYYYKKWNIN-TNN--KPYLKPLFGILA
...|  ||||.|.     .     ..|| . |...|..||.|  . ..| . .   .|.|......| ..|..  ...|      .  . .|. |  . .
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeves

--KNQLENGNRPIVVACNDGVGCSGTFLTAYSQIER-AKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGMLQ
  ... .. . |.|| |  ||| .|.|   |. ..   | .|. || | ... | ||   |   |..  . |   |.|. .|.
ayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvld

0046845 (Phosphotyrosine protein) phosphatases II 1966-2125 7.4e-47 155.4 In-house 115-278 (284) alignment
Range on Protein: 1966-2125
Range on HMM: 115-278/284.0
DSNKCAQYWPEKvNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDD-DSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP--PKGPPLVVHCS
. .|||||||.. .|. ...| ...... |||. .||.| | .|. . .. |. .||.. | ||||||| .   ...|.. .|  ..  |.|.| |||||
grekcaqYwple.gevltygd.ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs

AGVGRTGTFIVIDTMLQRMKQEN---TLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGE
||||||||||..|..|.....|.   ...... . ..| ||   ||| |||..... |....... 
aGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

subfamily_PTPRG_pd Subfamily PTPRG 1959-2132 7.5e-47 154.8 In-house 121-298 (563) alignment
Range on Protein: 1959-2132
Range on HMM: 121-298/563.0
YITK-ITTDSNKCAQYWPEkvNETHKLdDGIIIRTKTEEVHCWYTKRQLLITK-----DDD-SMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP
 ||.      .|| .|||.  .|. .. . . .. ..|||.. ||.|.| | .      ..      ...|. | |||||||  ..  ..|.     ...
mitnlvergrrkcdvYWPk..desety.galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaank

PKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEK
 .  |.|||||||||||||.||.||.|....|||. |...|| .|| ||  ||||.||||..|. | . |. .||    |.
aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq

0051299 (Phosphotyrosine protein) phosphatases II 1966-2121 1.9e-46 154.2 In-house 130-286 (288) alignment
Range on Protein: 1966-2121
Range on HMM: 130-286/288.0
DSNKCAQYWPEkvnETHKLDDGIIIRTKTEEVHCWYTKRQLLITKD----DDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHC
. .|||||||.   ....  . | .... |||.  ||.|.| .|.      |. |  .||.. | ||||||| .   ...|.  .|  ....|.| ||||
grekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHC

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
|||||||||||..|..|.....|......... ..|.||  .||| |||..... |....
saGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1969-2146 2.7e-46 153.1 In-house 132-308 (319) alignment
Range on Protein: 1969-2146
Range on HMM: 132-308/319.0
KCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSM-SMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPP-KGPPLVVHCSAGVG
|. .||||.  |.      .|.  . ||    | .|.| . |  . . .  ..|.| | ||||.|| .   .. .. .|| ..   .  |.|||||||||
klkkywpeenfeey...GrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvG

RTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKNED
|||||||.| ||.|.|.|..|... .  ..| || ..||..|||..|.. | . ...|.| . ... . |.|.|..|. |
RtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvad

subfamily_PTPRG_pd Subfamily PTPRG 2144-2401 2.8e-46 152.9 In-house 14-286 (563) alignment
Range on Protein: 2144-2401
Range on HMM: 14-286/563.0
NEDEECEFQKEFE-LLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTEN-----DYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQ
  |..  |..||| | .|  ... ... | . .|...||    ..|...|| |... .     |||||....||. .. ||.|| ||..|  ||| || .
hadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWe

QNCSVIVLLHP---VGTDEIPQFWPPqmGQAKKYQDLTVEHSLEKEENDYQIITLELKF---K--N--ESAHNVTLYYYKKWNiNTNNKPYLKPLFGILA
|| ..||..      |  . ...||    ....|. |.|    |.    |.. || .|    |  .  .. ..|. | | ||  ...   .  |      
qnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP.dhgvPehslpvLifvk

KNQLENGN--RPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
|..  | .   |||| |. ||| .||..   . ... ..| . ..|.|... |.||. ||   | ||. |. | | 
kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea

0036941 (Phosphotyrosine protein) phosphatases II 1966-2128 3.3e-46 153.3 In-house 116-284 (297) alignment
Range on Protein: 1966-2128
Range on HMM: 116-284/297.0
DSNKCAQYWPEKVNETHKLdDGIIIRTKTEEV--HCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP--PKGPPLVVHC
. .|||||||....|. .  ..........||  . .|| |.| .|. ... |  .||.. | ||||||| .   ...||. .|  ..  |.|.| .|||
grekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHC

SAGVGRTGTFIVIDTMLQRMK---QENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSF
||||||.||||..|.|||...    |....|.......|.||   ||| |||....  |........| .
saGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke

0047943 (Phosphotyrosine protein) phosphatases II 1966-2120 1.8e-45 150.9 In-house 115-271 (273) alignment
Range on Protein: 1966-2120
Range on HMM: 115-271/273.0
DSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPP--KGPPLVVHCSA
. .|||||||....|...  . ...... ||.. .||.|.| .|. ... |  .||.. | ||||||| .   ...||. .| ..    ...| ||||||
grekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsa

GVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
|||||||||..|..|.... |....... . ..| ||   ||| |||..... |...
GvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2140-2402 2.8e-45 149.8 In-house 14-288 (325) alignment
Range on Protein: 2140-2402
Range on HMM: 14-288/325.0
LRKKNEDEECEFQKEFELLKelSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMI
. ||. ...  | .||.||   || . .   .   .|...|||   ......||.|     |.. ||||||... .|  . |. .| || .|  |.| ..
vekkkaqdqdgfahefgllp..sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlv

HQQNCSVIVLLHPV--GTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNES-AHNVTLYYYKKWN-INTNNKP-YLKPLFGILAK--
 . .|||.|.|  .  | |.  ..|| .||..|..  | |.    .|  ||    |..|  ..  .  |  . .. |. . ....|  | ..  .. .  
ldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs

NQL---ENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
...    ..  ||.| | .||| .|.|.. || ...  .|   |||.|..| | .|| .|.. ..|| ..| | |. 
ervtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_PTPRA_pd Subfamily PTPRA 1966-2134 3e-45 149.5 In-house 139-308 (330) alignment
Range on Protein: 1966-2134
Range on HMM: 139-308/330.0
DSNKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSM----SMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHC
. .|||||||..   |.     | .  . |.|   || |..|...  |..    |  .. . .| ||| |||.. | |.... ... ... .. |.||||
keekcaqywPdeGlvty...GnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhc

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQ
||||||||||||.|..|.|.| |. .....|. ..| ||  .|||.||| .|.| | ..   |.| . .   .
saGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2154-2400 1.7e-44 147.4 In-house 3-253 (284) alignment
Range on Protein: 2154-2400
Range on HMM: 3-253/284.0
EFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHpv
||  . .|.  ... . .   .|...||.   |......| |. .      ||||||...||.  . .| || ||.||  ||| || ..||| ||||   
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

gTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEEndYQIITLELKF--KNESAHNVTLYYYKKWNiNTNNKPYLKPLFGILAK----NQLENGNRPIVVACN
  |   |.|| .. . ..  .. |.   | ||  | .  .||    |..   ... .... |  .     |  .|. .. |    .. ||....||| | 
.kdkcsqywplkivikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwp.dvgvpdypsdlmrlvkkvrhltskenhranivvhcs

DGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
 ||| .|....    ..| | |   |...|.|. | ||. ||. | .| ...  | |
agvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPRA_pd Subfamily PTPRA 2138-2401 2.6e-44 146.4 In-house 21-294 (330) alignment
Range on Protein: 2138-2401
Range on HMM: 21-294/330.0
KELRKKNEDEECEFQKEFELLKElSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWT
.|.|..  |.   |..||. |   ..  .|.  .   .|.|.||.   |||...||||       | ||||||...|||  . || .| |...|  ||| 
eeirirsaddnklfreefnalPa.gpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwr

MIHQQNCSVIVLLHPV---GTDEIPQFWPPQmGqAKKYQDLTVEHSLEKEENDYQIITLELK-----FKNESAHNVTLYYYKKWN---INTNNKPYLKPL
|| .|. . ||.|  .     .   |.|| . | .  | ...||   |.. .|| .  . ..      .....  |. .... |    . .. .  || |
miweqksativmltelkerkeekcaqywPde.G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkll

FGILAKNQLEnGNrPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
  . ..|| . .. |||| |  ||| .|||..  . .|| |.|.. |.|.|... | ||| .|  .|.| .... | ||
kkvkklnqqs.ag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

DSPc_SM00195 1962-2121 3.7e-44 146.4 In-house 102-262 (263) alignment
Range on Protein: 1962-2121
Range on HMM: 102-262/263.0
KITT-DSNKCAQYWPEKVNETHKLDdGIIIRTKTEEVHC-WYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
.  . ...||..||||. ... . .  | . .. .| .  ....|.| .||.... .  .|.|| . ||||||| ..  .....  .. ..  . .|.||
eeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
||||||||||||..||..|.....|....| . . ..|.||. .|||.|||..|.. ... |
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1962-2121 3.7e-44 146.4 In-house 102-262 (263) alignment
Range on Protein: 1962-2121
Range on HMM: 102-262/263.0
KITT-DSNKCAQYWPEKVNETHKLDdGIIIRTKTEEVHC-WYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
.  . ...||..||||. ... . .  | . .. .| .  ....|.| .||.... .  .|.|| . ||||||| ..  .....  .. ..  . .|.||
eeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
||||||||||||..||..|.....|....| . . ..|.||. .|||.|||..|.. ... |
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_CG7180_pd Subfamily CG7180 2143-2401 6.8e-44 144.7 In-house 11-289 (296) alignment
Range on Protein: 2143-2401
Range on HMM: 11-289/296.0
KNEDEECEFQKEFELLKELSdtTSTISCSIAMDNQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQ
| .. . |...|..| ..|.  . .  . .  .|.|.||    .||...||.|.    . ..|||||..|...   . .|||. | ..|  .||......
krrkfrveyklelkltprle..igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvyde

NCSVIVLLHPVGTDE--IPQFWPPQMgqAKKYQDLTVEHSLEKEENDYQIITLELKFK---------NESA--HNVTLYYYKKWNINtNNKPYL-KPLFG
..| .| |  ..  .   |..||...   ..|... ||   ||.  . .| |. |. |         ...|    |.|. ...|... .. |.  . |  
eisavvvLtktfdfakmypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWele.dkvPlstnalie

ILAKNQ-------LENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
.. . .        .. . |.|| ..||.. || .|..   .| .. |.  |.|..... | .||.||.  | | |. ..| |.
lrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

subfamily_PTPRB_pd Subfamily PTPRB 1966-2125 9.4e-44 144.6 In-house 132-289 (293) alignment
Range on Protein: 1966-2125
Range on HMM: 132-289/293.0
DSNKCAQYWPEKVNEThkLDDGIIIRTKTEEVHCWYTKRQLLITKddDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTH--PPKGPPLVVHCSA
   || .|||.. ...  |   | .  ..||.   .. |.|.|.|  ..... ...|. | ||||||| .   ...|. ..| ..    .  |.||||||
gkvkCeeYWPadeepv..lyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsa

GVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGE
||||||||| .|..||....|....|. .. ..|..| .||||..|||.||... | .. .|
GvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2149-2402 1.3e-43 144.0 In-house 6-266 (283) alignment
Range on Protein: 2149-2402
Range on HMM: 6-266/283.0
CEFQKEFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVE---GYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVL
 ...  .| ||.||       .. | .|.. ||..  .|..  || |.   .|||||...     || .. .|..| ||..|. ||| |..... . ||.
nnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm

LHPVGTDE---IPQFWPPQmGqAKKYQDLTVEHSLEKEENDYQIITLELKFK--NESAHNVTLYYYKKWnINTNNKPYLKPL--FGILAKNQLENGNRPI
| ..  |.     |.|| . | ...| ..||    |  .| . |  | |. .   .|.  .. | .  | .. .... .  |  |  .  .| |. . ||
ltklqedlrikCsqyWPkr.G.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPi

VVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
|| |  |.| ...|..| . .. |.|| | |.|. ..  | ||...|  |..|   |||  | |
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1965-2127 2.5e-43 143.5 In-house 136-296 (298) alignment
Range on Protein: 1965-2127
Range on HMM: 136-296/298.0
TDSNKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKG-PPLVVHCSA
.|  |. .|||.. .||.   . | .. . .|..  ...|.| ..| . . .  . . . |.|||.|||  .  .. .....| ..   |  |..|.|||
ldktkyhkywPdegkety...geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsa

GVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETS
||||.||||.||..|.|.|.|... ... .  .|..|...|||.|||..|..   . ...... 
GvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde

0043336 (Phosphotyrosine protein) phosphatases II 1965-2120 4e-43 143.3 In-house 125-276 (278) alignment
Range on Protein: 1965-2120
Range on HMM: 125-276/278.0
TDSNKCAQYWPekvnETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAG
 ...|||||||    ....  ... .... ||.. .|| |.| .|.  |. |  .|||. . ||||||| .   ...|.  .|   .... |..||||||
lgrvkcaqYwp....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaG

VGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
||||||||.....|.... | ...... . ..|.||   ||| .||..... |...
vgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

Y_phosphatase Protein-tyrosine phosphatase 1959-2118 7.8e-43 141.9 Pfam-A 72-234 (235) alignment
Range on Protein: 1959-2118
Range on HMM: 72-234/235.0
YITKITT-DSNKCAQYWPEKVNETHKLDDGIIIRT-KTEEVHCWYTKRQLLITKDDDS-MSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGP
 .|. .  ...||||||||. .|. . .|  .  . |..| .  || |.| ..|....  .  ......| ||||||| ..  ....|.... .. .|  
mltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksg

PLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
|.||||||||||||||...|..|.....|......... ..|.||. .||. ||||...| ..
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 1959-2118 7.8e-43 141.9 In-house 72-234 (235) alignment
Range on Protein: 1959-2118
Range on HMM: 72-234/235.0
YITKITT-DSNKCAQYWPEKVNETHKLDDGIIIRT-KTEEVHCWYTKRQLLITKDDDS-MSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGP
 .|. .  ...||||||||. .|. . .|  .  . |..| .  || |.| ..|....  .  ......| ||||||| ..  ....|.... .. .|  
mltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksg

PLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
|.||||||||||||||...|..|.....|......... ..|.||. .||. ||||...| ..
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0037934 (Phosphotyrosine protein) phosphatases II 2168-2401 8e-43 142.1 In-house 2-241 (243) alignment
Range on Protein: 2168-2401
Range on HMM: 2-241/243.0
ISCSIAMDNQERNRFDYNLPYNHTRVILRDteNDYINASWVEGYKtgNwFIVTQIPLQNTQTD----FWTMIHQQNCSVIVLLHPV---GTDEIPQFWPp
.|... . |...||.   |||.|.||.| .  .|||||.......  . .|.|| ||..|  |    || |.......||| | .    |    .|.|| 
fsiallpenlsknrysdilpydhsrvkleg..sdyinanliyvtp..r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

qmGQAkKYQDLTVEHSLEKEENDYQIITLELKFKNESAHNVTLYYYKKWNINTNNKPY-LKPLFGILAKNQ----------LENGNRPIVVACNDGVGCS
  |.   | |.||.   |.. .|| . ||.|. .... .  . . |  ...  .. |   ..|  .| . .           .....|..| |  ||| .
..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFLTAYSQIERAkteGvSDIFQFIRKARSQRPG-LVDCLERYIYCHELLCEY
||...||  ...    |  |... ... |.||||  |  .. |....|.|.|.
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_PTPRK_pd Subfamily PTPRK 2147-2400 8.2e-43 141.4 In-house 20-275 (314) alignment
Range on Protein: 2147-2400
Range on HMM: 20-275/314.0
EECEFQKEFELLKELsdttstISCSIAMDNQERNRFDYNLPYNHTRVILRDTE----NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSV
|   |..|.| | |         ..   .|.|.||.   |.|...||.|  ..    .|||||.....||  . ||||| |||.| .||| .....||. 
egygfkeeyeslfeg......wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencas

IVLLHPVGTDE---IPQFWPPQmgqAKKYQDLTVEHSLEKEENDYQIITLELKF---KNESAHNVTLYYYKKWNINtNNKPYLKPLFGILAK--NQLENG
||.|  .         ..|| .   ...|.|. ||    . .... . .. ..    . |  . |  . . .|    .   . . |......  .. |..
ivmltelvevgrvkClkyWPed...tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqeee

NRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
. .||| |  | | .|||..  . .. ...||| |.|. ... ||... .|.  |.|..... . |
aGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_PTPN6_pd Subfamily PTPN6 2126-2404 9.1e-43 141.4 In-house 2-299 (306) alignment
Range on Protein: 2126-2404
Range on HMM: 2-299/306.0
TSFAIEKAQYRIKELRKKNED-EECEFQKEFELLKEL-SDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRD---TENDYINASWVEGYKT--GNWFI
||.  .. . |..||.|..|. |   |..||| |..  . .. . . .  ..|.|.||.   ||..||||||..   ...|||||. ...  .   . .|
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyi

VTQIPLQNTQTDFWTMIHQQNCSVIVLLHP---VGTDEIPQFWPPQMGQAKkYQDLTVEHSLEKEENDYQIITLELK--FKNESAHNVTLYYYKKWN-IN
 ||  |..| .||| |. |.|. |||..      | .   ..|| .  . . | ...|..  ||. .||.. .| ..   |......|  | .|.|   .
atqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhg

TNNKPY--LKPLFGILAKNQLEN--GNRPIVVACNDGVGCSGTFLTAY---SQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEG
. ..|.  |. |  . .|..  .   ..|||| |..|.|  |||.      ..||. ...   || ......|.|| |||   . | . .. . .| | 
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

0039614 (Phosphotyrosine protein) phosphatases II 1960-2124 1.1e-42 141.9 In-house 132-292 (297) alignment
Range on Protein: 1960-2124
Range on HMM: 132-292/297.0
ITKITTDSNKCAQYWPEKVNethkLDDGIIIRTKTEEVHCWYTKRQLLITKddDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP--PKGPPL
.|| . ...||||||||...      ... ......|..  || |.| .|.  .. |  .||.| | ||||||| .  ....|.. .|  .   ||| | 
Ltklvelgrkcaqywpeegg....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpv

VVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCG
.||||||||||||||....||.... | ...... . ..| ||   ||| .||..... |.......
lVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0045450 (Phosphotyrosine protein) phosphatases II 1966-2121 1.4e-42 141.9 In-house 145-304 (307) alignment
Range on Protein: 1966-2121
Range on HMM: 145-304/307.0
DSNKCAQYWPEKvNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKD-DDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP--PKGPPLVVHCS
...|||||||.. .|.   .. . .... ||..  || |.| .|    ...|  .||.. | ||||||| .   ...||. .|  .   ||| | .||||
grekcaqywPde.geeltygn.ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

AGVGRTGTFIVIDTMLQRMKQENT---LNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
||||||||||....||.....|.|   ..... . ..| ||   ||. |||..... |....
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1961-2121 1.5e-41 137.3 In-house 122-279 (288) alignment
Range on Protein: 1961-2121
Range on HMM: 122-279/288.0
TKI-TTDSNKCAQYWPEKVNEThKLDDGIIIRTKTEEVHCwYTKRQLLITKDDDsmSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
|..   . .|| .|||.. ... .  .  .. ....|..  ...|.||. |. .   . ||.|| ..||||||| .|  .. .....  ... .  |..|
telveggktkCeeYWPdadkpk.nyGsvtvtlveskeled.fvlrklllekkkt..eleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiiv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
|||||||||||||..|........|..... ... ..|.|| .||||..||..|.. |.. |
hCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1964-2196 4.2e-41 135.6 In-house 122-354 (515) alignment
Range on Protein: 1964-2196
Range on HMM: 122-354/515.0
TTDSNKCAQYWPEKVNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDsmSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSA
  |  ||..|||.|  .. |.   | . . . |     .||.| ..|.||  | ..| ...| |||.||| .   .. .| ...  |     ||..||||
egdkikcgkyWPdkpgdsvkfGs.ikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsa

GVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKNED-EECEFQKEFELLKELS
|||||| .| || .. ..|. .......|. .|| .|  ||||.||| .|.  . ...   .|   . .    ...|    .      . |||. || | 
GvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslc

DT--TSTISCSIAMDNQERNRFDYNLPYNHTRVILR
    .|   .. . ||. .||.  ||| .. |||| 
pdppasqtrsgrtrdnhpknrygnnlplqrnrvild

subfamily_Ptp69D_pd Subfamily Ptp69D 1952-2140 1.1e-40 134.7 In-house 114-305 (307) alignment
Range on Protein: 1952-2140
Range on HMM: 114-305/307.0
EAVELYSYITKITTDSN-KCAQYWPEKvnETHKLDdGIIIRTKTEEVHCWYTKRQLLITKDDDSM-----SMAITHYQLTVWPDHGVPVDKIVMISFIDN
  |.|   ....|  .. |||.|||.   .. . .  |....  || |  |..|.| ..| ...      |  .. |. | |.|  ||     .. .|..
qevtlivmlsnlteknrkkcakYWpie..devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieq

IRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKEL
.|  .  .  |.||||||||||.|.|. .| .||..|.|....|...  ..|.||  |||  |||......|.|... |.|  .... . .|..|
vrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1960-2122 1.1e-40 134.5 In-house 115-277 (281) alignment
Range on Protein: 1960-2122
Range on HMM: 115-277/281.0
IT-KITTDSNKCAQYWPEKVNeTHKLDDgIIIRTKTEEVHCWYTKRQLLItKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNI-RLTHPPKGPPL
.| .| ..  || .|||.. . . |. | .......|| .  | .|.. . . ... .  ... . | ||||||| .   ...| ... .||.. .  ||
vtreieagklkChrYWPddns.elkygd.vtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkapl

VVHCSAGVGRTGTFIVIDTMLQRMKQE-NTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQ
|.|||||||||||.| .|........| ..|.. . . ..|..|  .|||  || ...| . | ..
vihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

0045098 (Phosphotyrosine protein) phosphatases II 1965-2125 2.5e-40 134.0 In-house 101-276 (278) alignment
Range on Protein: 1965-2125
Range on HMM: 101-276/278.0
TDSNKCAQYWPEkvnETHKLDDGIIIRTKTEEVHCWYTKRQLLITKD----DDSMSMAITHYQLTVWPDHGVPVDK--IVMISFIDNIRLTHP-------
 . .||||||||   . ..  ... .... |||.  ||.| ||.|       | .|. .||.... ||||||| .     ...... ||  .        
lgrekcaqywpe...ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

------PKGPPLVVHCSAGVGRTGTFIVIDTMLQRMkqENTLNIYDFLLQIRHQRIT-LVQTKEQYIYIHKSLADHIQCGE
      ..| | .||||||||||||......||...  |....... . ..| ||    ||..|||..... |......|.
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk

0042113 (Phosphotyrosine protein) phosphatases II 1966-2119 3.1e-40 133.5 In-house 90-241 (245) alignment
Range on Protein: 1966-2119
Range on HMM: 90-241/245.0
DSNKCAQYWPEkvNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP-PKGPPLVVHCSAG
. .|||||||.  .|. . .| .......||.. .|| |.| .|.. |. |  ..||. . ||||||| .   ...|.. .|     ... |..||||||
grvkcaqywpl..gesltygd.ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaG

VGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLAD
||||||||....||.... | ...... . ..| ||   ||| .||..... |..
vgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0040439 (Phosphotyrosine protein) phosphatases II 1966-2121 4.2e-40 133.3 In-house 92-246 (249) alignment
Range on Protein: 1966-2121
Range on HMM: 92-246/249.0
DSNKCAQYWPEkvnETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHP--PKGPPLVVHCSA
. .|||||||.   ....  ... .... .||. .|| |.| .|.  |. |  ..|.| | ||||||| .   ...||. .|  .   ||| |..|||||
grekcaqywpl...ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsa

GVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
|||||||||....||.... |....... . ..|.||   ||. |||..... |....
GvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_PTPN12_pd Subfamily PTPN12 1963-2122 1.1e-39 131.0 In-house 118-278 (290) alignment
Range on Protein: 1963-2122
Range on HMM: 118-278/290.0
ITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSmaITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCS
.  . .||..||||...|. . ..  .  .. . |.  .. |.| ......| .  .. .. | |||||||  .  ....|...| ..  .  |||||||
velgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrk..vyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCs

AGVGRTGTFIVIDTMLQRMKQENT---LNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQ
|||||||| |.|| . . .|.|..   |...| .|..|.|| .|||||||| ...|..|. .|
aGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2150-2401 3.8e-39 129.4 In-house 20-276 (315) alignment
Range on Protein: 2150-2401
Range on HMM: 20-276/315.0
EFQKEFELLKELSDttSTISCSIAMDNQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVL
 | .||  | .     .    .   .|...||.. .||....||.|     . ..|||||| ...... . .| .| ||. .  ||| |. |.. . ||.
lfseefhdlpdPdi..yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivm

LHPVGT-DE--IPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLeLKFKNESAHNVTLYYYKKWNINTNNKPYLkPLFGILA--KNQLENGNRPIVV
.      |     |.|| . ... ..  . ||    .   |  .  |    | |. ..|| . ...|  .  .|     |. ..   | . .. . ...|
vtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts.sllklikevkadngkkefsllv

ACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
 |  ||| .| .... . ....| . . |.|.|... |..|| ||   |.| . .. . |.
hcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled

subfamily_PTPN12_pd Subfamily PTPN12 2144-2408 4.6e-39 129.0 In-house 3-283 (290) alignment
Range on Protein: 2144-2408
Range on HMM: 3-283/290.0
NEDEECEFQKEFELLKELSDT-----TSTISCSIAMDNQERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTM
... | ||.|||. ||.||.      . . ... .. |...||.   |||...|| |. .    ..|||||....| .    .| .| || .| .||| |
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

IHQQNCSVIVLLH---PVGTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEEN-DYQIITLELKFKNESaHNVTLYYYKKWNINTNNKpYLKPLFGIL--AK
| ..| ...|..     .|     ..|| ..... ......|. . ||  . |. | ||......|| ..|. . |..|      .   |.|. ..  ..
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkes.rkvyqfhYtaWPDhgvPs.saksllelielvr

NQLENGNRPIVVACNDGVGCSGTFLT---AYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGMLQH
.  |. . |.|| |  |||  || ..   ....... |..   |.|. ... | ||. ||   |.| . .. . |. .  |. 
elqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkelei

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2172-2400 1e-38 128.1 In-house 45-277 (315) alignment
Range on Protein: 2172-2400
Range on HMM: 45-277/315.0
IAMDNQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPPQmgq
  . |...||.   ..|...|| |     | . ||.||....||.  . .| .| |. ..  ||| ........ ||.|  .  .|     ..|| .   
kkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...

AKKYQDLTVEHSLEKEENDYQIITLELKFKNEsAHNVTLYYYKKWNiNTNNKPYLKPLFGIL--AKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERA
   |  .|| .  |. ...| . ||   |...  ..|  . |  |  ...   |  ||  .   .|   .|   .||| |..||| .|||.|  . ...|
kviyGkitvtrkseevnteytvrtlsvvfgdn.irevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqa

KTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
..| . |...||.. |..| ..|. .|.| . .. | |
eaenaidvynfitgvrqnrikmvqvaeqyqfiydalle

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2054-2141 1.3e-38 127.5 In-house 192-267 (267) alignment
Range on Protein: 2054-2141
Range on HMM: 192-267/267.0
GPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHiqcgetsfaiekAQYRIKELR
..||||.||.||||.|||.|||..|.|.|.|....|.|||..||.|||.||.|||.|||||..||..            |..|.||..
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey............aegrlkeee

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1961-2123 1.6e-38 127.4 In-house 84-244 (250) alignment
Range on Protein: 1961-2123
Range on HMM: 84-244/250.0
TKITTDSNKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPP-KGPPLVV
|...   ... |||| .. |..    .. .  . .|..  ||||.| ..|   . .  . ... .|||| |||     .. ...... ...  .  |..|
tnLkesektyhqywPvekaeky...GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPviv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQC
.|||||||.|.||.||..|.|.|.|......... ..|..|.  |...|||..... .   ...
qCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_PTPN6_pd Subfamily PTPN6 1965-2123 1.6e-38 127.4 In-house 135-299 (306) alignment
Range on Protein: 1965-2123
Range on HMM: 135-299/306.0
TDSNKCAQYWPEKVNETHklDDGIIIRTKTEEVHCWYTKRQLLIT-KDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPP----KGPPLVV
   .|||.|||.. ....     | ... .|. .  |. |.|... |.... .  . .|. ..||||||| |. ....|.....  .      .  |.||
rgkekCarYWPdeeekee..yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivv

HCSAGVGRTGTFIVIDTMLQRMKQEN---TLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQC
|||||.||||||||||..|. ....     ..|...  ..|.||  ||||..|| ...|... .|. 
hCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2174-2404 2.5e-38 126.7 In-house 26-270 (274) alignment
Range on Protein: 2174-2404
Range on HMM: 26-270/274.0
MDNQERNRFDYNLPYNHTRVILR-----DTENDYINASWVEGYKT-GNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPPQMGQ
. .|..||.   || ...||.|.     | . .|||| .. ||..  . .. || ||.|| .||| ||.|....|||.|  .   .     ...| . . 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

--AKKYQDLTVEHSLEKEENDYQIITLELKFKNEsAHNVTLYYYKKWNIN---TNNKPYLKPLFGILAKNQLENGN-RPIVVACNDGVGCSGTFLTAYSQ
  ...|.|. .. .  .|.|||.. .| ||  ..  ..|. |.| .|  .    . .. |. .  .  ... || .  |.|| |  |.|  | |...   
eiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

IERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEG
. . . |.| |... . . | .| |.|.  |.| . |. ||.|.. 
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr

subfamily_PTPN13_pd Subfamily PTPN13 1966-2117 2.6e-38 126.9 In-house 115-265 (273) alignment
Range on Protein: 1966-2117
Range on HMM: 115-265/273.0
DSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPpKGPPLVVHCSAGV
.  || .||||. |.. |. . . ..    . .  .. |.| ... . . |  ..| ... |||||||     .. |. ..|  .  .  |.|||||||.
gkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGi

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSL
||.||.|.||..|. ..... ... . . ..|.|| ..||||.|||...|..
GrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_PTPRK_pd Subfamily PTPRK 1960-2140 4.1e-38 125.9 In-house 117-296 (314) alignment
Range on Protein: 1960-2140
Range on HMM: 117-296/314.0
ITKITTDS-NKCAQYWPEKVNEtHKLddgIIIRTKTEEVHCWYTKRQLLITK--DDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPP
.|...  .  || .||||. .  ..    | .     |... . .| . ..|     .    . ..| . ||||.||| .  ..... ..  .....  .
ltelvevgrvkClkyWPedtev.ygd...ikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGr

LVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKEL
.||||||| |||||||.||..|. ...|......    ..| ... .|.|.|||..|.  . .   ||||.  . . .   .| 
ivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyles

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2139-2403 1.3e-37 124.4 In-house 5-277 (281) alignment
Range on Protein: 2139-2403
Range on HMM: 5-277/281.0
ELRKKNEDEECEFQKEFELLKELsDTTSTISCSIAMDNQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTM
.|........  |..|.| |... .. .| . | | .|...||.     |..||| .    .....|||||..|.|||  . .|.|| |. .. ..|| |
hlkqlsqndnaGfieeyeklaai.gvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IHQQNCSVIVLL-HPVGTDEI--PQFWPpQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESAHNVTLYYYKKWN---INTNNKPYLKpLFGILAK
. .|. |.||.. . . .. .   ..|| .  .. || |.||..  |.|.. |   ...|. ..  . .|.   |..|    . .. |  |.     . |
vweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkelle.frkevlk

NQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTE-GVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 . .. . |.|. |  ||| .||...    ......|    |. . ... | .|  .|  . .| . .  . .. .
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1964-2126 2.1e-37 124.2 In-house 136-296 (319) alignment
Range on Protein: 1964-2126
Range on HMM: 136-296/319.0
TtdSNKCAQYWPEKVNETHKLDD-GIIIRTKTEEvhcwYTKRQLLITKDDDS-MSMAITHYQLTVWPDHGVPVDKIVMISFIDNIR-LTHPPKGP-PLVV
|   .||.|||| |......  .  .   ..|.|    |. |.. ...|        || . .  |||.|||   . .. .....| ||.  ... ..||
t..kdkcsqywplkivikeerfkvkvdsveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGET
||||||||||..||.|..|.|||.|. ...|.|. ..| || ||||   || .|. .| ..   | .
hcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1964-2144 2.4e-37 124.0 In-house 100-278 (284) alignment
Range on Protein: 1964-2144
Range on HMM: 100-278/284.0
TtdSNKCAQYWPEKVNETHKLDD-GIIIRTKTEEvhcwYTKRQLLITKDDDS-MSMAITHYQLTVWPDHGVPVDKIVMISFIDNIR-LTHPPKGP-PLVV
|   .||.|||| |......  .  .   ...||    |. |.. ...|        |. . .  |||.|||   . .. .....| ||.  ... ..||
t..kdkcsqywplkivikeerfkvkvdsveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKN
||||||||||..||.|..|.|||.|. ...|.|. ..| || ||||   || .|. .| ..   | .  |.      ..|| .| 
hcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnks

subfamily_PTPN3_pd Subfamily PTPN3 1961-2116 3e-37 123.1 In-house 116-270 (280) alignment
Range on Protein: 1961-2116
Range on HMM: 116-270/280.0
T-KITTDSNKCAQYWPEkVNETHKLDdGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
|  .     || |||||  ... ..  .. .. . |. .  |  |.|.... . . .  |.. | . ||||||| |.  ...|....| ..  |  |.||
ttlverGrvkChqyWPe.tedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKS
|||||.|||| .|...| |. . ... ... | . ..| || .||||..|| .. ..
hCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2158-2402 3e-37 123.3 In-house 30-284 (297) alignment
Range on Protein: 2158-2402
Range on HMM: 30-284/297.0
LKELSDTTSTISCSIAMDNQ---ERNRFDYNLPYNHTRVILRDTEND----YINASWVEGYKTgnWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV-
 . |   ...|  .   ...   |..|.   |||.  ||.|. ...|    |.|||.|.|.|    .| || | ..|  |||.|. ... |.||.|    
eeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddn

-GTDEIPQFWPPQmGqAKKYQDLTVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYKKWNINTNNK----PYLKPLFGILAKNQLENGNRPIVVACN
 ....  ..|. . |  ... |..|. .  .| . .   .||..  .  . . |  | . .|  .. ..    ..|  |   . |.  .| . |..| | 
erdkkcaryWsdk.g.vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhcl

DGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
 |||  | .||  | . .|| |   |||....| | .|| ||   | | . .... |. 
aGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal

0037934 (Phosphotyrosine protein) phosphatases II 1966-2118 6.7e-37 122.7 In-house 86-239 (243) alignment
Range on Protein: 1966-2118
Range on HMM: 86-239/243.0
DSNKCAQYWPekvNEThkLDDGIIIRTKTEEVHCWYTKRQLLITKDD-DSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLT--------HPPKGPP
. .|||||||   .|.    ........ ||..  || | ||..  | |  .  ..||. . ||||||| .   ...|.| .|          . ..| |
grekcaqywp...gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggp

LVVHCSAGVGRTGTFIVIDTMLQRMkqenTLNIYDFLLQIRHQRIT-LVQTKEQYIYIHKSLA
..||||||||||||.|....||...    ...... . ..| ||    ||| .||..... |.
vlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1963-2131 1.5e-36 120.9 In-house 127-289 (315) alignment
Range on Protein: 1963-2131
Range on HMM: 127-289/315.0
ITTDSNKCAQYWPEKvnethK-LDDGIIIRTKTEEVHCWYTKRQLLITKDDDSmsMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHC
.  . .|. .|||.|     | .   | .  | |||.  || | | .. .|.     .  ...| ||| |||   | .. .| ...  |  .  ..||||
vegekrkaekywpdk.....kviyGkitvtrkseevnteytvrtlsvvfgdni..revvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhc

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIE
||||||||||| .|..|.... || ...|.|. ..|..|| .||. ||| .|.. | . . ||.|| | .
saGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqd

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2176-2401 1.6e-36 120.5 In-house 43-275 (515) alignment
Range on Protein: 2176-2401
Range on HMM: 43-275/515.0
NQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVG-TDEI--PQFWPPQMGQAKKY
| ..||.  .|||. .||.|     . ..||.||| ...... . .| .| |.. .  ||| .. |.| . |...      | |   ..|| . |.. |.
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

QDLTVEHSLEKEENDYQIITLELkFKNESAHNVTLYYYKKWNINTNNKPyLKPLFGILA--KNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEG
  . ||    .   .  . .|..  |.. .. || . ...|  .  .|   . |. ..   | . .. . |... |  |||  | .... | . .|||  
Gsikvelvsleactggikrkltv.lkgddsrtvtqfhfteWPdkGvpkh.tssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttr

VSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
. |.|.|... | .|| ||   |.| . .. . |.
mvdvfnfvtnirqkrpylvqtqeqyafiygavled

subfamily_PTPN9_pd Subfamily PTPN9 1961-2120 1.7e-36 120.8 In-house 117-289 (297) alignment
Range on Protein: 1961-2120
Range on HMM: 117-289/297.0
TKIT-TDSNKCAQYWPEKVNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRL-----------
|..  .   ||.||||.. .....  | . ...   |..  |..|.| |.. ... |  .||.|.. |||.||| .   .. .....|            
trvvergrlkcgqyWpleeessaefgd.lsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgd

--THPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
  . .|.|||.|||||||.||||||| .|  |.|.....|... . . ..| ||   .|| ||| . .... ..
ewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1966-2122 7.6e-35 115.2 In-house 102-265 (270) alignment
Range on Protein: 1966-2122
Range on HMM: 102-265/270.0
DSNKCAQYWPEKVNETHKLDDGII-IRTKTEEVHCWYTKRQLLITkdDDSMSMAITHYQLTVWPDHGVPVDKI------VMISFIDNIRLTHPP--KGPP
  .||..|||....|. || || | ... .|| .  | ...| ..  ... .  ..|.. . ||||||| ..        ... . ..| ..    |. |
grkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaeP

LVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQ
|.||||||||||||.|..|.... ..... ...   . ..|..|. |||. ||| ...|... ...
llvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1961-2142 9.9e-35 114.9 In-house 119-298 (315) alignment
Range on Protein: 1961-2142
Range on HMM: 119-298/315.0
TKIT-TDSNKCAQYWPEKVNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDsmSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
||    |  ||.||||..  .. ..   | . .   |     ..|.| . | ..  |  .| .|.| |||.||. .   .. .| ...  . .|  .|.|
tkkqegdkikcrqywPdrkadsvefGs.ikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRK
|||||||||| .| || .....|.........|. ..| .|. ||||.|.| .|. .. ....  .|   . .   ....|. 
hcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlht

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1957-2053 2.2e-34 113.7 In-house 12-118 (267) alignment
Range on Protein: 1957-2053
Range on HMM: 12-118/267.0
YSYITKITTDSNKCAQYWPEKVNETHKLDDG-------IIIRTKTEE------VHCWYTKRQLLITKddDSMSMAITHYqLTVWPDHGVPVDKIVMISFI
.  |.||...|....|...||..|...|||.       .|.|||.||      |....||.....|.  |.....||.. |||..|..|||.......|.
felikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtq..dplkntitdf.ltvihdqkvpvivlltkvft

DNIRLTHPPK
|||||..|||
dnirlfwPPk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1962-2124 7.5e-34 111.9 In-house 124-286 (290) alignment
Range on Protein: 1962-2124
Range on HMM: 124-286/290.0
K-ITTDSNKCAQYWPEKvnETHKlDDGIIIRTKTEEVHCWYTKRQLLITKDDD-SMSMAITHYQLTVWPDHG-VPVDKIVMISFIDNIRLTHPPKGPPLV
. |  ...|| ||||..  .|..  . . |.   ||..  |..|.| .....    .  .|.||.| |...| |.  . .....   ..  . .   ..|
niieegkvkCqqYWpds..dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsiv

VHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCG
||||..|||...|....| ....|.|   .... | . | |.  .|||..|| .|.. .   ... 
vHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2147-2401 8.7e-34 111.6 In-house 13-292 (301) alignment
Range on Protein: 2147-2401
Range on HMM: 13-292/301.0
EECEFQKEFELLKELSDTTSTISCSiaMDNQERNRFDYNLPYNHTRVILRDTEN------DYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNC
.. .|..... ||| .| ..|...|   .|.. |||  . .|.. |.||. ..|      .|||||...||.  . ||..| |...| .||| .| |.  
hsnkfeeqykelkegedksctvgls..eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

SVIVLLHPVGT---DEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNES----------------AHNVTLYYYKKWNINT---NNKPY
. || .        ..  |.||    . ...  .||. . |.   |. |  | .| .. |                ...|. .   .|  .    . .  
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LKPLFGILAKnQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
|. .  .. . |   |  |.|| | |.|. ||.. .    .| .| ||| |.|| ..  | ..|| |  || |.  .. . .|
Lqviddvihr.qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy

subfamily_PTPN13_pd Subfamily PTPN13 2152-2398 1e-33 111.8 In-house 14-265 (273) alignment
Range on Protein: 2152-2398
Range on HMM: 14-265/273.0
QKEFELLKELSDTTSTiSCSIAMDNQERNRFDYNLPYNHTRVILRDTENdYINASWVEGYKTGN--WFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLH-P
..||. |.||  . .. . .   .|...||.   |||..|||.| |  . |||||...     .   .|..| || .| .||| |. .|...||...   
aeefkelrelkpldtc.evgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

VGTDEI--PQFWPPQMGQAKKYQD-LTVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLENGNRPIVVACND
. ....   ..|| ....  | .. |.||    .. ..... .|..| .. . ...|.   . ||      .  .. |  .   ..|.. . |||| |  
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsa

GVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELL
|.| |||..| .  ..  . .   |. . .|| | || |.|   ..||.... .
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_PTPN1_pd Subfamily PTPN1 2159-2391 1.5e-33 110.8 In-house 13-260 (290) alignment
Range on Protein: 2159-2391
Range on HMM: 13-260/290.0
KELSDTTSTISCSI--AMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVG---TDE
..... .| ....      |...||.    ||.|.|..|....||||||| ||  .    .|.|| || || . || |. .|..  .|.|  |    .  
ldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

IPQFWPPQMG-QAKKYQ--DLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWN---INTNNKPYLKPLFGILAKNQLENGNRPIVVACNDGV
  |.|| .   .. ...   |.|.   |.... |.. .|||.  | . ..... ..| .|.   .      .|| || .     | .   | |. |  |.
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GCSGTFL---TAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERY
| ||||    |   .||. .     || . . ..|..| ||.   .. 
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadql

subfamily_PTPN3_pd Subfamily PTPN3 2165-2401 4.5e-33 109.4 In-house 30-275 (280) alignment
Range on Protein: 2165-2401
Range on HMM: 30-275/280.0
TSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVE----GYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV---GTDEIPQF
  .||..   .| ..||.   |||..|||.|...|.|||||..|.    . .. | .|.|| ||..| ||||.|...|..|.||.|  .   |     |.
glaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPPqMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYKKWN---INTNNKPYLKPLFGIlaKNQLENGNRPIVVACNDGVGCSGTFL
||  ...  .| ...|. . |.|.. | .  | || |. .  ....   |  |    . .... .|. .  .  ... .  ..|.|| |  |.| .| ..
WPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv..rklrsgkeePvvvhCsaGigrtGvli

TAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE-Y
.    .    ..    . . .|. | ||  ||.  ..| .  | ... |
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1958-2122 5e-33 109.3 In-house 102-269 (274) alignment
Range on Protein: 1958-2122
Range on HMM: 102-269/274.0
SYITKITTDSN-KCAQYWPEKVNE-THKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDsmSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPK--
  .||..   . |||.|.|.. .   ..  ... |...    .  |. |.|.. .  .  .  ..||  | |||| .| |   ......... ..  .  
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeena

-GPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQ
   | |||||||.|||| || |.  ......|.....     ..| .|  .|||.||| .||. |. . .
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1963-2117 6.3e-33 109.0 In-house 80-235 (237) alignment
Range on Protein: 1963-2117
Range on HMM: 80-235/237.0
ITTDSNKCAQYWPEKvNETHKLdDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMA-ITHYQLTVWPDHGVPVDKIVMISFIDNI--RLTHPPKGPPLVV
|  .  || .|||.  ..       . .  | .|  . || | ||..|      .  |  ||.|.|||.|||     .. |  ||  |  | ..  | ..
iegnelkchkywpst.dqpaay.gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwii

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSL
|||||||||| |.|||.||.. |... ..||...  |  .|  ..|||.||..||...
hcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti

PTPc_DSPc_SM00012 2019-2118 9.4e-33 107.9 In-house 2-104 (105) alignment
Range on Protein: 2019-2118
Range on HMM: 2-104/105.0
ITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPK--GPPLVVHCSAGVGRTGTFIVIDTMLQRMKQE-NTLNIYDFLLQIRHQRITLVQTKEQYIYIHK
..||. | ||||||| .   .........  .  .  ..|.||||||||||||||...|..||....| ....|.... ..|.|| ..|||.|||.....
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

SLA
 |.
all

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1959-2128 4.1e-32 106.5 In-house 122-291 (297) alignment
Range on Protein: 1959-2128
Range on HMM: 122-291/297.0
YITKITTDSNKCAQYWPEKVNEThklDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPV--DKIVMISFIDNIRLTHPPKGP-
 ...     .|||.||..|   |      . . ... .  . . ||.| .||..  .   .  || . |||. |.   .   .. .|...| ..  .   
mlnddnerdkkcaryWsdkgvtt...fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg

PLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSF
||.|||.||||||| .. || .. ..|.|....|.... ..|..|  |||||||| .... . . . . .|  
PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtri

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2173-2405 4.9e-32 106.0 In-house 17-267 (270) alignment
Range on Protein: 2173-2405
Range on HMM: 17-267/270.0
AMDNQERNRFDYNLPYNHTRVILRDTEN----DYINASWVEGYKTG-NWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHP---VGTDEIPQFWPPQMGQ
|  ... ||.   ||  .|||.| . |.     |||| .|.|..   . .| .. ||..| ..|| || ... . ||.. .    |...  ..||.. ..
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

AKKYQDLTVEH--SLEKEENDYQIITLELKfKNESAHNVTLYYYKKWN-----INTNNKPYLKPLFGILAKN-----QLENGNrPIVVACNDGVGCSGTF
  |..| ...   . |. |. | .  |.|. .. . .... ..|..|.      ..... . . |  .|..      .|.... |..| | .||| .||.
kvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtl

LTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGM
..    ..  ....  |. . |.. | .|. ||.  |.| . .. . |||| .
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1964-2127 1.2e-31 104.7 In-house 122-284 (287) alignment
Range on Protein: 1964-2127
Range on HMM: 122-284/287.0
TTDSNKCAQYWPEKVNetHKLDDgIIIRTKTEEVHCWYTKRQLLITKDD-DSMSMAITHYQLTVWPDHG-VPVDKIVMISFIDNIRLTHPPKGPPLVVHC
 .| ..| |||||. .    | .   |.   |||.  |..|.| ..... ..    .. ||.| |...| |.  . ... . . ..  . .   ..||||
endeevcyqyWpeeks..vvlGe.yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhC

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETS
|..|||...|. ..| ... |.| ...... | . | |. . ||| |||..| . .  .....|| 
sdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1963-2116 2.5e-31 103.7 In-house 86-235 (239) alignment
Range on Protein: 1963-2116
Range on HMM: 86-235/239.0
ITTDSNKCAQYWPEKVNETHKLDdgiIIRTKTeEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCS
|    .|| ||||.  ..  .|    .   || || . |  | .....  ..    . .|..|||||.|||     .. .  .|     |   | |.|||
ieghkkkchqywpdstskycnlr...vtlrkt.evfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcs

AGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKS
|||||||.|.|||.||.. |...|..|....  || .|  .||| |||..|| .
agvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1963-2116 2.7e-31 103.6 In-house 87-236 (239) alignment
Range on Protein: 1963-2116
Range on HMM: 87-236/239.0
ITTDSNKCAQYWPEKVNETHKLDdgiIIRTKTeEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCS
|    .|| ||||.  ..  .|    .   || || . |  | .....  ..    . .|..|||||.|||     .. .  .|     |   | |.|||
ieghkkkchqywpdstskycnlr...vtlrkt.evfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcs

AGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKS
|||||||.|.|||.||.. |...|..|....  || .|  .||| |||..|| .
agvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_PTPN1_pd Subfamily PTPN1 1964-2123 4.7e-31 102.6 In-house 107-273 (290) alignment
Range on Protein: 1964-2123
Range on HMM: 107-273/290.0
TTDSNKCAQYWPEKVN-ETHKLD-DGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTH--PPKGPPLVV
  ...|||||||.. . .. .|.   . ..  .||..  || |.| ...     .  |.|.  | ||| |||     ...|. ..| .    ..  | |.
ekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavi

HCSAGVGRTGTFIVIDTMLQRMKQEN---TLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQC
|||||.||.|||...||.| ......   ...| . ||..|..|. |.||..|  . . .. . ...
hcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1964-2144 2e-30 101.0 In-house 126-311 (325) alignment
Range on Protein: 1964-2144
Range on HMM: 126-311/325.0
TTDSNKCAQYWPEKVNETHKLdDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRL-----THPP-KGPPL
 .. ..||.|||... .. ..  |. .. .| |    | .|.| . . ..  ....  .||  |.| ||.     .||... .       |       |.
dlgkdrcavywpkemgksktf.GglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpi

VVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQYRIKELRKKN
.|||||||||||.|| . ..|... .|  ..|..|. ..|..| ..|.| .||| |...|.. . .|.|   .   . ..  |...|
lvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqern

0036282 (Phosphotyrosine protein) phosphatases II 1960-2115 1e-29 98.9 In-house 44-164 (174) alignment
Range on Protein: 1960-2115
Range on HMM: 44-164/174.0
ITKITTDSNKCAQYWPEkvnethklddgiiirtkteevhcwytkrqllitkDDDSMSMAITHYQLTVWPDHGVPVDKIvMISFIDNIRLTHPP-KGPPLV
.. .  .. || .||||                                  . ....  . .|. . ||||||| . | ...|.. ..  .   .| |..
leekelglykcinywpe..................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHCSAGVGRTGTFIVIDTMLQRMKqENTLNIYDFLLQIRHQRITLVQTKEQYIYIHK
||||||||||||..... ||.... |.. ...|.. ..| ||   ||| .||.....
VHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2138-2402 2.7e-29 96.9 In-house 4-277 (287) alignment
Range on Protein: 2138-2402
Range on HMM: 4-277/287.0
KELRKKNedeecEFQKEFELLKELSdTTSTI--SCSIAMDNQERNRFDYNLPYNHTRVILRDTE---NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFW
.|.| |.     . .||.. ||| |  .||.    .  . . ..||.   ||...|||.|  .     ||||| .| .|.  . ||..| |.  |  |||
eerrvkd.....dvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfw

TMIHQQNCSVIVLL-HPV--GTDEIPQFWPPQmGQAKKYQDLTV-EHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWnINTNNKPY----LKPLF
... ... ...... . |  .  .. ..|| .  .  .    .|   . .. | .| . .| |   . . |. |  . . .|  .    |     ..  .
ravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllsw.PdkvlaPtavglirfvl

GI---LAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
 .   .  ..  ..  |.|| .. |.| ||..|. .  ..| .  |  |. . . . | .| .|| .  .. .  | |  | 
dvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy

subfamily_PTPN14_pd Subfamily PTPN14 2136-2401 3.6e-29 96.7 In-house 12-295 (300) alignment
Range on Protein: 2136-2401
Range on HMM: 12-295/300.0
RIKELRKKNEdeECEFQKEFELLKELSDtTSTISCSIAMDNQERNRFDYNLPYNHTRVIL---RDTENDYINASWVEGYKTGN--WFIVTQIPLQNTQTD
|.| | || |  | .  .|.| ... .   ...|..   .|.|.|||   |||...|| |   ......||||| ..   .|.   .||.| ||..| .|
rakilekkle..egkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqd

FWTMIHQQNCSVIVLLHPV---GTDEIPQFWPPQ--MGQAKKYQDLTVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYKKW---NINTNNKPYLKP
|| |. .|. ..||.|      | .   ...| .    .  ...   |   . .. . .  ..|.||.   .   .|    |. |   ..  . |..|. 
fWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsy

LFGI---LAKNQ--L--ENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
|  .     | .     .. . |..| | .||| .|  ...   |.  ... . || . ... | ||  ||. | .| . ...| .|
LeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

0051429 (Phosphotyrosine protein) phosphatases II 1966-2120 5.3e-29 97.1 In-house 59-224 (272) alignment
Range on Protein: 1966-2120
Range on HMM: 59-224/272.0
DSNKCAQYWP---------EKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKD-DDSMSMAITHYQLTVWPDHGVPVDKivMISFIDNIRLthppkGP
...|| .|||         .   ..  |   . ...  ||..  |. | ||.|.  . .... ..|.. | ||||||| .   ...... ..      | 
grlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....gg

PLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLN--------IYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
|..||||||..||||..... .|...  |  ..        ..... ..| ||   ||| |||..... |.. 
pvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2175-2398 6.1e-29 95.9 In-house 2-235 (237) alignment
Range on Protein: 2175-2398
Range on HMM: 2-235/237.0
DNQERNRFDYNLPYNHTRVILRDT--ENDYINASWVEGYK-TGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVG---TDEIPQFWPpQMGQAKKY
.|. .||.     |.|.||.|. .  . |||||....|.  | . .| .| ||...  ||| |. |..|||||.|  .         ..|| .  | . |
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaay

QDLTVEHSLEKEENDYQIITLELKFKNESA--HNVTLYYYKKWNI---NTNNKPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAK
  |||    ..|  || . .| |  . .      .  | .  |       .    |.    |. ...  .   | .. |. ||| .| ||   . . .||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

TEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELL
 . | ||....     .|| ...  ..|.. |. .
ekkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2149-2395 3.3e-28 93.2 In-house 20-229 (392) alignment
Range on Protein: 2149-2395
Range on HMM: 20-229/392.0
CEFQKEFELLKELSDTTSTisCSIAMDNQERNRFDYNLPYNHTRVIL----RDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIV
. | .||  | .      |  ..   .|...||.. .|||. .||.|      ...||.|||....... . .| .| |   .  ||| |..|.| . |.
alffeefhdlpgpdiypqt..vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttia

LLHPVGTDEipqfwppqmgqakkyqdltvehslekeendyqiitlelkfKNESAHNVTLYYYKKWNINTNNKpYLKPLFGILAKNQLENG--NRPIVVAC
..  .   .                                        | ..|. |. ... .|  .   | .   |. .. . . . |   .|... |
mvtklkegd........................................kgddartvaqfhftewPdkdvpk.htssllkfikevkadfGqythpliihc

NDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCH
. ||| .|  ..  | . .||.  . |.|.|. . | .|| .|.  |.| . .
sagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiy

0051429 (Phosphotyrosine protein) phosphatases II 2200-2409 5.5e-28 93.8 In-house 4-232 (272) alignment
Range on Protein: 2200-2409
Range on HMM: 4-232/272.0
NDYINASWVEGYkT----GNWFIVTQIPLQNTQTDFWTMiHQQNCSVIVLLHPVG---TDEIPQFWP----------PQMGQAKKYQDLTVEHSLEKEEN
..||||..| || .     . .. .. ||..|. |||.. .......|| | ..     .  ...||          . . .   | .|.| .  |.  .
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYQIITLELKFK--NESAHNVTLYYYKKWNINTNNKPYLKPLFGILAKnqlengNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSD--------IFQ
|| . .|.|...  .. |. |....|  |      . .|. |. .|..      ..|..| |. |.. .||.  ..  ...   | . |        ...
dyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

FIRKARSQRPGLVDCLERYIYCHELLCEYAEGMLQHE
.... |.|||| |   | |....| | |.....|. .
aveelraqrpgavqteeqylflyeallellrsllsvr

subfamily_PTPN14_pd Subfamily PTPN14 1951-2122 9.8e-28 92.0 In-house 115-297 (300) alignment
Range on Protein: 1951-2122
Range on HMM: 115-297/300.0
EEAVELYSYITKIT-TDSNKCAQYWPEKVNETHKLDDG-IIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRL
|. |.|   .|...    .|. .|.|.. .. .... |   . ||  |    .. ..| .     .    . | | | ||||||| |   ..|...... 
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

---T----HP--PKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQ
         .   . ||..|||||||||||  |. | ... ........|   | ..|.|| .||||  || ...| |  ...
vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1960-2129 1.3e-27 91.4 In-house 106-274 (283) alignment
Range on Protein: 1960-2129
Range on HMM: 106-274/283.0
ITKITTD-SNKCAQYWPEKVNETHkldDGIIIRTKTEEVHCWYTKRQLLITKD-DDSMSMAITHYQLTVWPDHG--VPVDKIVMISFIDNIRLTHppKGP
.||.  |   ||.||||..  | .       .  . |  .  .....||. ..     .. ..|||.  | . |   ... .| .  .   .  .  |  
ltklqedlrikCsqyWPkrGsedy...GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes..kkg

PLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFA
|.|||||.|.|||..|| . . .. .. |  ....  .  .| ||...|||..||  .|.   ..  ||.|  |
PivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia

0041856 (Phosphotyrosine protein) phosphatases II 2176-2402 1.5e-27 91.8 In-house 1-171 (182) alignment
Range on Protein: 2176-2402
Range on HMM: 1-171/182.0
NQERNRFDYNLPYNHTRvilrdtENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHpvgtdeIPQFWPpqmgqakkyqdltveh
|...||.   |||.|.|       .|||||... |.  .. ||.|| ||..|  ||..|........|| |        .. ||                
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp................

slekeendyqiitlelkfkneSAHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLenGNRPIVVACNDGVGCSGTFLTAYSQIERakteGvSDIFQFIR
                     .  . . . |.....  .. | |  |. .. . .    ..|..| |. ||| .||.  ||  ...    |  .... ..
.....................ellerlgiqylylpwpDhgvpdldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavk

KARSQRPGLVDCLERYIYCHELLCEYA
  ||.||| | ... |.... .|.|. 
lvrsrRpgmvitpnqyfflqlallell

subfamily_PTPN23_pd Subfamily PTPN23 1962-2113 1.7e-27 91.0 In-house 117-272 (288) alignment
Range on Protein: 1962-2113
Range on HMM: 117-272/288.0
KITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHcWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRL----THPPKGPPL
|  .. .|...||||. .||.| .|  .   ...| .  . .|.| ..  | .    ..| ||| ||..|||    ... |.|...     .. .   ||
keelgkpkvdrYwPedkgetvkfgdlsvtlksvrete.thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPl

VVHCSAGVGRTGTFIVIDTMLQRMKQENTL-NIYDFLLQIRHQRITLVQTKEQYIYI
||||||||||||.| .. . .. ....| | .| . . ..|.||   ||.|||.   
vvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfs

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2142-2400 1.8e-27 90.9 In-house 13-277 (439) alignment
Range on Protein: 2142-2400
Range on HMM: 13-277/439.0
KKNEDEECEFQKEFELLKELSDTTSTISCSIAMDN-QERNRFDYNLPYNHTRVILRDT----ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIH
| . ...  |...|| ..  |   . |.. .| .  | .||.    ...||||.|...       |||| ...|| . . .| ||.| ..|  ||| .. 
kldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvi

QQNCSVIVLLHPVGtdEIPQFWPPQmgQAKKYQDLTVEHSLEKEENDYQIITLELKFKN---ESAHNVTLYYYKKWN---INTNNkPYLKPL-FGILAKN
..... || |  .   |  ..|| .  .   | |..|    . |  .| |  . .  .    |  . |  ..|  |    . ..   ..  .   | . |
ekktvtivmltnlv..esykywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqa.shvldflrainsan

QlENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
. ..   |.|| |  ||| .|| ..    .|. |.|   ||   ..  | ||  .|. | .|.. .. . |
d.keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_PTPN9_pd Subfamily PTPN9 2149-2309 2e-27 91.0 In-house 16-183 (297) alignment
Range on Protein: 2149-2309
Range on HMM: 16-183/297.0
CEFQKEFELLKELsDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIV
   .||.. ...   .. |. .|    | |.||.   | |..||| |     |.. |||||..|.|||  . || || ||..| .||| |. .|.. |||
rGlskeyaeirne.pveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

LLHP---VGTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELK-FKNESAHNVTLYYYKKW
.       |     |.||.. ...... ||.|..   .||.||.. .||.|  |.|   .|| . .  |
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsW

0049772 (Phosphotyrosine protein) phosphatases II 2173-2404 6.5e-26 87.2 In-house 43-282 (314) alignment
Range on Protein: 2173-2404
Range on HMM: 43-282/314.0
AMDNQERNRFDYNLPYNhTRVILrDTEN----DYINASWVEGYktgNWFIVTQIPLQNTQTDF----------WTMI--HQQNCSVIVL-LHPVGTDE--
   |...||.   ||.. .|||| ....    ||||||.| |.   . ||.|| ||..|  ||          |.|.   ..|. .||   . |  ||  
lflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------IPQFWPPQmgqakkyqD---------LTvehslekeendyQIITLELKFKNESAHNVTLYYYKkWNINtnNKPYLKPLFGILAKNqleNG
          ........        .         |             ....   .|...  . . .  .  .. .     ... .. .. ..   . 
rLdaAlgKtpllildgng........neptaadlellk............eelydpelferlgikylripvpD.gsap..lledfdeflefieea...dk

NRPIVVACNDGVGCSGTFLTAYSQIERAKTeGVSDIFQFIRKARSQR--PGLVDCLERYIYCHELLCEYAEG
..|..| |..|.| .|||..|.  . . .   . ......|..|. .  ||..  ||.|....| |.|| . 
ggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf

0043147 (Phosphotyrosine protein) phosphatases II 1990-2114 1.5e-25 85.3 In-house 54-154 (172) alignment
Range on Protein: 1990-2114
Range on HMM: 54-154/172.0
IrtkteevhcwytkrqlliTKDDDSMSMAITHYQLTVWPDHGVPvDKIVMISFIDNIRL-THPPKGPPLVVHCSAGVGRTGTFIVIDTMLqrmkqeNTLN
                   ..| .  .  . .|. . ||||||| .  ....|.. |.   .  .| | .||||||||||||..... ||        |.
l..................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgls

IYDFLLQIRHQRITLVQTKEQYIYIH
... . ..|..|   ||...||....
leeavalvrekRpgavqnpsqyrfly

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1966-2119 1.9e-25 84.1 In-house 132-281 (290) alignment
Range on Protein: 1966-2119
Range on HMM: 132-281/290.0
DSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppkGpPLVVHCSAGV
   ||.||.|||  |.  . .  .. .. ..      |. | . . |.  .  . |...  |||. |.  .. ..  .  .| .    | |.|||||||.
GkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkas...G.pvvvhcsaGi

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLAD
||||||. |.. || . .   |.. |    .|. |.. ||   ||. . . | |
GrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

0041856 (Phosphotyrosine protein) phosphatases II 1961-2125 2.8e-25 84.4 In-house 66-175 (182) alignment
Range on Protein: 1961-2125
Range on HMM: 66-175/182.0
TkittdsnkCAQYWPEKVnethklddgiiirtkteevhcwytkrqllitkdddsmSMAITHYQLTVWPDHGVPVdKIVMISFIDNIRLthppKGPPLVVH
|        . .||||..                                       ....|. . |||||||     ...||. ..     .| | .||
t........eelywpell.....................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVH

CSAGVGRTGTFIVIDTMLQRmkqenTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGE
||||||||||..... |...      ..... . ..| .|   |.| .||....  | .......
CsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2176-2396 3.1e-25 83.7 In-house 7-234 (239) alignment
Range on Protein: 2176-2396
Range on HMM: 7-234/239.0
NQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKTG-NWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVG---TDEIPQFWPPqmgQAKK
|. .||.   . |.|.||.|     |  .||||||..  |    . .| ||  .. .  ||| |. |.   |||.|  .      .  |.||     . |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...stsk

YQDLTVEHSLEKEENDYQIITLELKFKNE-SAHNVTLYYYKKWNINTnNKPYLKPLFGILAK---NQLeNGNRPIVVACNDGVGCSGTFLTAYSQIERAK
| .| |     .   || | |. .    .   . |  |..  |  .     |   ..|.  |   . |  | || |. |. ||| .|.||   . . .||
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkg.vpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidamlrqak

TEGVSDIFQFIRKARSQRPGLVDCLERYIYCHE
 .   |||....  | .|| .|.  |.|.. | 
kqktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2147-2405 3.3e-25 83.1 In-house 24-288 (302) alignment
Range on Protein: 2147-2405
Range on HMM: 24-288/302.0
EECEFQKEFELLKELSDTTSTisCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQ---TDFWTMIHQQNCSVI
.. | .|||. ....   .    |..  .| ..|. .    .....|.|  ....|.||| ||  . ..  |..|.| ....    .|| |..|...  .
dtaevkkefkkidtmkvdlek..CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsv

VLLhpVGTDEI----PQFWPPQMGQAKKYQDLTVEH-SLEKEENDYQIITLELKFKNESA-HNVTLYYYKKWN---INTNNKPYLKPLFGILAKNqlENG
|.|  ||..|.     ...| ..|. |.|... |     || |.. .  ..|.  .. |    ...|  . |.   . ..     |   .. ||.  ...
vil..vgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakk..ika

NRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGM
. ..|.. . |.|  |.|||.   .|. ...    | . ... |||||  || |. |.  .  |  |    
dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2176-2396 3.3e-25 83.6 In-house 8-235 (239) alignment
Range on Protein: 2176-2396
Range on HMM: 8-235/239.0
NQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKTG-NWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVG---TDEIPQFWPPqmgQAKK
|. .||.   . |.|.||.|     |  .||||||..  |    . .| ||  .. .  ||| |. |.   |||.|  .      .  |.||     . |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...stsk

YQDLTVEHSLEKEENDYQIITLELKFKNE-SAHNVTLYYYKKWNINTnNKPYLKPLFGILAK---NQLeNGNRPIVVACNDGVGCSGTFLTAYSQIERAK
| .| |     .   || | |. .    .   . |  |..  |  .     |   ..|.  |   . |  | || |. |. ||| .|.||   . . .||
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkg.vpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidamlrqak

TEGVSDIFQFIRKARSQRPGLVDCLERYIYCHE
 .   |||....  | .|| .|.  |.|.. | 
kqktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1962-2118 6.4e-25 82.4 In-house 130-286 (305) alignment
Range on Protein: 1962-2118
Range on HMM: 130-286/305.0
KITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEeVHCWYTKRQLLITKDDDS----MSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPpkgpPL
 . .   |||||||    | ..|  ||..   .   .      .. ||  . .     .|.. | | | ||| |||  |.  . ..  || ..     |.
tvelgklkcaqywpaaqgeklelksgivvenvsg.skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv....pi

VVHCSAGVGRTGTFIVIDTMLQRMKQENT-LNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
|||||||.||||| . |. .|... ...    . ...  .| ||   .|.  ||..||. . 
vvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvml

0049260 (Phosphotyrosine protein) phosphatases II 1966-2114 6.9e-25 82.9 In-house 47-143 (152) alignment
Range on Protein: 1966-2114
Range on HMM: 47-143/152.0
DSNKCAQYWpekvnethklddgiiirtkteevhcwytkrqllitkdddsmsmaitHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGV
.  ||.||.                                              .|. . ||||||| . .... ... |.     || | .|||||||
gklkceqyi..............................................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGv

GRTGTFIVIDTMLqrmkqeNTLNIYDFLLQIRHQRITLVQTKEQYIYIH
|||||..... ||      . ....... ..| .|   |....|.....
gRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

0036282 (Phosphotyrosine protein) phosphatases II 2200-2396 9.3e-25 82.7 In-house 2-164 (174) alignment
Range on Protein: 2200-2396
Range on HMM: 2-164/174.0
NDYINASWVEGYKTGNWFIVTQIPLQntqtdFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPPqmgqakkyqdltvehslekeendyqiitlelKFKNE
.||||||.. ..   . .|..| ||.     || |.........| | .   ..   ....||                                . . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SAHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKtEGVSDIFQFIRKARSQRPGLVDCLERYIYCHE
. ......|.     .. . . |  .. .. . ..|....|..| |. ||| .||.  ||  . . . |.. |.....|..|.|||| |   . |.....
erlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy





subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1965-2133 1e-24 81.8 In-house 126-291 (439) alignment
Range on Protein: 1965-2133
Range on HMM: 126-291/439.0
TDSNKcaqYWPEKVNeTHKldDGIIIRTKTEEVHCWYTKRQLLITKDDD--SMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPK-GPPLVVHC
 .| |   ||| . . .      |..|.  .     |. | . . .. |      .. ... . |||. || .   .. |.  |  .   .   |.||||
vesyk...ywpsdae.vcy..gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhc

SAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKA
||||||||| | .|  |...| || ..|   .  .|.||  .||.  ||..|.... . |. |... .|.. 
sagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1966-2126 1.6e-24 81.1 In-house 123-298 (301) alignment
Range on Protein: 1966-2126
Range on HMM: 123-298/301.0
DSNKCAQYWPEKVNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDSM---------------SMAITHYQLTVWPDHGV-PVDKIVMISFIDNIRLT
  .|| ||||.  .|...    . .  . | |.  .. ||| ..  | |                |. .. .|.| ||..|| .  . |. .  | |  .
tkskceqywpnseaeseefgp.ftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrq

HPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGET
. . | |.|||||..|.|.|... ..  |   | |   ....    .|...   |.| |||. |.. .   .|. .|
qkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1962-2119 3.1e-24 80.5 In-house 116-275 (307) alignment
Range on Protein: 1962-2119
Range on HMM: 116-275/307.0
KITTDSNKCAQYWPEKVNETHKL-DDGIIIRTKTEEVHCWYTKRQLL-IT---KDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppkgPP
 | .   || |||| .  ..    . .  |  .   ..      .|. .|    |  . | .|.|.| . |||.|||  ..  | ... .|  .     |
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt....np

LVVHCSAGVGRTGTFIVIDTMLQRMKQ-ENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLAD
.||||||||||.|| . |  . ..| . .|  .. ... ..| ||   .||. ||.|.|. | .
vvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

subfamily_PTPRN_pd Subfamily PTPRN 2148-2397 3.3e-24 80.1 In-house 28-287 (297) alignment
Range on Protein: 2148-2397
Range on HMM: 28-287/297.0
ECEFQKEFELLKELSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRD----TENDYINASWVEGYKT-GNWFIVTQIPLQNTQTDFWTMIHQQNCSV
.  ..||.| |..     || . . | .| ..||    |||.|.|| |..    ...|||||| .         .| || || .| .||| |. .| . |
kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

IVLLHPVGTDEIP---QFWPPQMGQAkkYQDLTVEHSLEK-EENDYQIITLELK-FKNESAHNVTLYYYKKWNiNTNNKPYLKPLFGILAK-NQLEN-GN
|| | ..  ...    ..|| .  .   |.   |.   |.   .|| . .. || .... .  || ...  |. ...  .  |.|.    | |.      
ivnltrleeegvkqckrywpdeGsev..yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswp.eegvPasaksllefrrkvnksyrGrs

RPIVVACNDGVGCSGTFLTAYSQIERAkTEGV--SDIFQFIRKARSQRPGLVDCLERYIYCHEL
 |||| | ||.| .|...     ..|  . ||   ||   . . | |||||| . ... ..   
cpivvhcsdGaGrtGvyilidlvlnrl.lkGvkeidiaatlehlrdqrpglvktkdqfefalta

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2010-2142 7.4e-24 78.9 In-house 127-257 (392) alignment
Range on Protein: 2010-2142
Range on HMM: 127-257/392.0
KDDDSmsMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQ
| ||    ... ...| |||..||     .. || ...  .     ||..||||||||||  | ||... . |.   .....|. .||..|  .||||||
kgdda..rtvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeq

YIYIHKSLADHIQCGETSFAIEKAQYRIKELRK
| .|. .. . .   .|   . .   ....|  
yafiygavledllwrntlipvvhftdhlqdlst

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2159-2402 2.9e-23 77.3 In-house 23-277 (307) alignment
Range on Protein: 2159-2402
Range on HMM: 23-277/307.0
KELSDTTS-TISCSIAMDNQERNRFDYNLPYNHTRVILRD--TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCS-VIVLLHPVGTDEI
..|.. |  ...      |...||..     ...|....      ||| | ..      . ||..| ||.||| .||.|. |..   ||.| . . . .|
rvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielaki

--PQFWPPQMGQAKKYQDL----TVEH----SLEKEENDYQIITLELKFKNESaHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLENgnrPIVVACND
   |.|| . || . . .     .|.      |  .|.  .. ||.... ..|   .. . ...|  .   .  |  .  . | .  .|   |.|| |  
kceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqks.rtiqhlqwenwpdrgvpqinltainlleavrydtn...pvvvhcsa

GVGCSGTFLT-AYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYA
||| ||| .. .. |    . .   |. ..... ||||.  .    .|.| | .| || 
GvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_ptpA1_pd Subfamily ptpA1 2151-2357 7.5e-23 75.9 In-house 23-251 (418) alignment
Range on Protein: 2151-2357
Range on HMM: 23-251/418.0
FQKEFELLKElSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDT---E-NDYINASWVEGYKTgNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLL
 ..|| ||.| |   |  |      |  .||.   || ||||| |.     | .||||| ...|    . ||.|| || || .||| |. .. | .||.|
ikeefrllee.svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivml

HPVGTD---EIPQFWPPQMGQAK--KY-------QDLTVEHSLEKEENDYQIITLELKFKNES-AHNVTLYYYKKW---NINTNNKPYLKPLFGILAK-N
     .   .  ..|| |.|  .   |          .||     .. . .||| ....  |  ....| | |. |   ||    .|. . |. |  . |
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

QL---ENGNRPIVVACNDGVGCSGTFLTAYS
|.    . | ||.| |. ||| .||| ||  
qiipssdrnvpiivhcsagvgrtgtfctavi

0046846 (Phosphotyrosine protein) phosphatases II 1965-2115 1.3e-22 75.8 In-house 60-167 (176) alignment
Range on Protein: 1965-2115
Range on HMM: 60-167/176.0
TDSNKCAQYWPEKVNETHklddgiiirtkteevhcwytkrqllitkdddsmsmaitHYQLTVWPDHGVPVDkIVMISFIDNIRLTHPPkGPPLVVHCSAG
... ||..||||  .. .                                      .|. . ||||||| .   ...... ||      | | .||||||
lgrlkcpnywpeleklgi......................................qylhlpwpDhgvpdl.elllellefirealke.ggpvlVHCsaG

VGRTGTFIVIDtmlqRMKQENTLNIYDFLLQIRHQRI-TLVQTKEQYIYIHK
.|||||.....     .. |. |.... | ..| ||    ||| ||| ....
igRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflye

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2170-2401 1.6e-22 74.5 In-house 48-282 (290) alignment
Range on Protein: 2170-2401
Range on HMM: 48-282/290.0
CSIAMDNQ--ERNRFDYNLPYNHTRVILRDT-ENDYINASWVEGYKTgnWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV---GTDEIPQFWPPQMG
 .|   |   ..||.      . |||||.|  . ||. | .|.| |.   ||.|| .|..|  |.| |. |.. ..||.|  .   |     |..| . |
rkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

QAKKYQDLTVEHSLEKEEnDYQIITLELKFKN-ESAHNVTLYYY--KKWNINTNNKPYLKpLFGILakNQLENGNRPIVVACNDGVGCSGTFLTAYSQIE
..  . ..||  |.|... | .||   |  .. .| ..  |...  | |  ..  .  |  |. .|    | . . |.|| |  |.| .||| .    ..
evltfGeitvlcseeddk.daniikktlsvrdkdsGkehklkhlkikswpdksvalstla.llrtl..rilrkasGpvvvhcsaGiGrtGtfvaievglq

RAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
        |. . .|  |  | . |.   .|.   |.| ..
illdGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1961-2120 3.3e-22 73.8 In-house 108-269 (285) alignment
Range on Protein: 1961-2120
Range on HMM: 108-269/285.0
TKITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHC-W--YTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHpPKGPPL
| .    .||| |.|||. |  |.    |  |. .|       .    .. |.|  |  . . | |.  |||.  | |   || .   ..    ||  |.
tlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn.pkekpi

VVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
.|||||||||| ||. ||    |. ..  ... | . ..|  |.  ||.. |.....  | ..
cvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey

0048076 (Phosphotyrosine protein) phosphatases II 1973-2115 3.6e-22 74.0 In-house 2-137 (145) alignment
Range on Protein: 1973-2115
Range on HMM: 2-137/145.0
YWPEKVNETHKLDDGIiIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPpKGPPLVVHCSAGVGRTGTFI
||| .. .   | .      . |. . .  .. | .| . .  .  ...|. . ||||||| .   ...|.. |.  .. .| | .||||||||||||..
ywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealk.eggpvlVHCsaGvgRtgtlv

VIDTMLQrmkqENtLNIYDFLLQIRHQRITLVQTKEQYIYIHK
... ||.    .. ..... | ..| ||   |.. .|......
aaylmll....lg.vsleealelvrsqrpgavpnpgqlrflye

0048179 (Phosphotyrosine protein) phosphatases II 2004-2115 3.7e-22 74.0 In-house 48-139 (144) alignment
Range on Protein: 2004-2115
Range on HMM: 48-139/144.0
RqllitkdddsmsmaITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPpKGPPLVVHCSAGVGRTGTFIVIDTMLqrmkqENTLNIYDFLLQIRHQRITL
               ...|. . ||||||| .   ...|.. |.  .. .| | .||||||||||||..... |.     .. |.... | ..| .|   
e..............giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpga

VQTKEQYIYIHK
|.. .|......
vpnpgqlrfLle

subfamily_PTPRN_pd Subfamily PTPRN 1962-2121 3.8e-22 73.4 In-house 133-292 (297) alignment
Range on Protein: 1962-2121
Range on HMM: 133-292/297.0
KI-TTDSNKCAQYWPEKVNETHKLDDgiiIRTKTEEVHC-WYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVV
..  .. ..|..|||.. .|.... .   ..  .| . |  |  | . .   . | . ..| .    ||..|||     .. |   .  ..  .  |.||
rleeegvkqckrywpdeGsevyhiye...vhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivv

HCSAGVGRTGTFIVIDTMLQRMKQ-ENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHI
|||.|.||||..|.|| .|.|...  . ..|   |  .| ||  ||.||.|. .. ...|. .
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_CG7180_pd Subfamily CG7180 1960-2125 4.8e-22 73.0 In-house 116-294 (296) alignment
Range on Protein: 1960-2125
Range on HMM: 116-294/296.0
ITKITTDSNKCAQYWPEKVneTHKLDDgIIIRTKTEEVHCWYTKRQLLITKD----------DDSMSMAITHYQLTVWPD-HGVPVDKIVMISFIDNIRL
.|| .  .... .|||.|    ..  . |.. . .|.     ..|.. .||            .     ....|||.|.  . ||.    .| ..  .||
Ltktfdfakmypsywpnks..keqyge.ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl

TH-----PPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGE
        |.  |.||..| |..|.| .. ||  |. ...|. ....... ..|..|  ||...|.| ||   | ... |. 
wrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

0043147 (Phosphotyrosine protein) phosphatases II 2198-2396 1.8e-21 72.1 In-house 3-155 (172) alignment
Range on Protein: 2198-2396
Range on HMM: 3-155/172.0
TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVgtdeipqfwppqmgqakkyqdltvehslekeendyqiitlELKFKNES
  .||||||....|   . ||.|| ||.||  ||| |........|| | .                                         ..  ....
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpelle

AHNVTLYYYKKWNINTNNKPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIeraktEGVsDIFQFIRKARSQRPGLVDCLERYIYCHE
 ......|.     .. .  .|  .. .. . .... . |..| |  ||| .||.  ||  .     .|. .... ..  |..||| |   . |.....
rlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrflyy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2016-2156 1.9e-21 70.9 In-house 88-230 (440) alignment
Range on Protein: 2016-2156
Range on HMM: 88-230/440.0
SMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKG-PPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIH
| .. .|.   |||.|||     .. .|...  ..   |  ||.||||||.||||  |..|..|.  |. . ..|. |.  .| .|  .||| ||| ..|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

KSLADHIQCGETSFAIEKAQYRIKELRKKNED-EECEFQKEFE
... . . ||.|    .    |.....  |   ... .|.|||
eavlegllcgdtliledditerveqiqwpnphtdksplqqefe

subfamily_egg_pd Subfamily egg 2150-2399 2.8e-21 70.5 In-house 15-267 (307) alignment
Range on Protein: 2150-2399
Range on HMM: 15-267/307.0
EFQKEFELLKELSDTTStISCSIAMDNQERNRFDYNLPYNHTRVILRD----TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVL
|... .|.|.|..|  | .  ... .|.|. |       . .|| |.       .|.| |  |.|    | ||..| ||.||. ||| |..|...  ||.
elerrlevleesvdeis.lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

LHP-VGTDEIPQFWPPQMGQAKKY--QDLTVEHSLEKEENDYQIITLELKFkneSAHNVTLYYYKKWNINTNNKPYLKPLFGILAKnqLENGNRPIVVAC
|   . ... . .||    .. ..    | .|    ... |      .||       .    . ..|. . ||   .   . .| |  | |  .|.|| .
ltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl...vGgddeerflehwqgdvnnssdvysplrvlrk..lrnlskpvvvqd

NDGVGCSGTFLTAY---SQIERAkTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLC
 .||  ..|....     .. |      | . . .   | .|.  |..  .|.. . |. 
ilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1968-2120 4.4e-21 69.9 In-house 128-286 (305) alignment
Range on Protein: 1968-2120
Range on HMM: 128-286/305.0
NKCAQYWPEKVNETHKLDD---GIIIRTKTEEVHCWYT------KRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRlthPPKGpPLV
.||..|.. | ... ....    |... .. .   . .      ..  |. .   . .  .|||    ||| |||   . .. .. . |   | || |.|
kkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar...pskg.piv

VHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFL-LQIRHQRITLVQTKEQYIYIHKSLADH
||||||.||||. .... .|... . . ..  | .  .|| ||   .|| .||...|. . ..
vhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2166-2401 5.3e-21 69.9 In-house 33-270 (288) alignment
Range on Protein: 2166-2401
Range on HMM: 33-270/288.0
STISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHP---VGTDEIPQFWPPQM
|  . .  ..|  |.|..     . ||| | |  . ||.|  |   |  . .| .| ||. |   .| |. ...   ||.|      | ..  ...| ..
sidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

GQAKKYQDLTVEHSLEKEENDYQIITLELKFKNESAHN--VTLYYYKKWNINTNNKPYLKPLfGILakNQLENGNRPIVVACNDGVGCSGTFLTAYSQIE
|.. ... |      .... |  .    |. ..|  ..  |   ....|. ..  . || ||  .|  . |.. ..|||| .. ||| .||.      .|
GekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylspl.rll..evlkslqkPivvhssaGvGrtgtlililiale

RAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
 .. .  . | ... | | .|   . .  .|.| | .. |.
slrlddflgirsllaklreerfkaiqtemqylyvhrcvlee

0044763 (Phosphotyrosine protein) phosphatases II 1967-2115 1.5e-20 69.1 In-house 63-165 (178) alignment
Range on Protein: 1967-2115
Range on HMM: 63-165/178.0
SNKCAQYWPEKVNethklddgiiirtkteevhcwytkrqllitkdddsmsmaiTHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGVG
 .|| .||||. .                                         .|. . .||||||     .  |.. |.  ...|| | .||||||||
flkcdpywpeeag........................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

RTGTFIVIDTMLQRmkqenTLNIYDFLLQIRHQRItLVQTKEQYIYIHK
|.||..... |...      |.... . ..| .|   |.. .|. ....
Rsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLye

0046846 (Phosphotyrosine protein) phosphatases II 2192-2402 4.9e-20 67.5 In-house 4-173 (176) alignment
Range on Protein: 2192-2402
Range on HMM: 4-173/176.0
RVILRDTENDYINASWVEGYktgnWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPP----QMgqakkyqdltvehslekeendy
|..  |   |||||... |.    ..|.|| || .|  ||. |.........| |      .   .|..||     ..                      
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

qiitlelkfknesahnvtL-YYYKKWNINTNNKPYLKPLFGILAKNQLENgnRPIVVACNDGVGCSGTFLTAYsqieRAKTEGVSDIFQFIRKARSQRP-
                    ...     .. .  .|  |. .. . . |.  .|..| |  |.| .||.. ||      ..|   .... ... |.||| 
..................qylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRpl

GLVDCLERYIYCHELLCEYA
| |   | | ...| .... 
gavqtpeQyrflyefellll

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1966-2134 1.3e-19 65.4 In-house 109-272 (290) alignment
Range on Protein: 1966-2134
Range on HMM: 109-272/290.0
DSNKCAQYWPEKVNETHKLDdGIIIRTKTEEVHCWYTKRQLLITKDdDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRlthpPKGPPLVVHCSAGV
..  ||.| ||.|.|  |.. |. .. |  | .    .|.|... | |   . .||..|  | .  |. |.....| |....     .. | .|||  |.
slfaCakYvpesvgeelkfk.gltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGi

GRTGTFIVIDTMLQRMK-QENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETSFAIEKAQ
 |  ..  |.   | .  ... ... | | ..|.|| ......... ..   .   ..    .|| |. .
SrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeete

0051082 (Phosphotyrosine protein) phosphatases II 1968-2115 1.5e-19 65.6 In-house 47-147 (151) alignment
Range on Protein: 1968-2115
Range on HMM: 47-147/151.0
NKCAQYWPEKVnethklddgiiirtkteevhcwytkrqllitkdddsmsMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLthpPKGPPLVVHCSAGVGR
..|..|.||                                        . ..|.... |||.|.|.    ...|.. ..    .|. |..||||||.||
gycpeylpelg......................................ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgR

TGTFIVIDTMLQRmkqentLNIYDFLLQIRHQRITLVQTKEQYIYIHK
|||..... ||..      ..... | ..| .|  .||...|......
TGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1952-2115 6.1e-19 63.0 In-house 99-289 (297) alignment
Range on Protein: 1952-2115
Range on HMM: 99-289/297.0
EAVELYSYITKITTDS-NKCAQYWPEKVNETHKLDDGIII--RTKTEEVHCWY-TKRQLlITKdddSMSMAITHYQLTVWPDHGVP-----VDKI-----
. |     ..|.  |  .||| |||. |.|  |  | ..    . ..| .  . |. || | .   | |  ..| |   |||||||     ...      
qdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelql.iyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvc

-------VMISFID-----------NIRLTHpPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHK
       .|.. ..            .|  . |.  .|.|||||||||.|  .  |..|......   ..  .| ..|.||  |||| ||. ....
scciavpmmlalvemftamvflqleslraem.prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyd

0049772 (Phosphotyrosine protein) phosphatases II 2012-2123 1.2e-18 63.4 In-house 173-282 (314) alignment
Range on Protein: 2012-2123
Range on HMM: 173-282/314.0
DDSMSMAITHYQLTVWPDHGVPvDKIVMISFIDNIRLThpPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKqentLNIYDFLLQIRHQRI-----TLVQT
..  . .. .|  . .||...| .   . .|.. |.    .|| |..|||.||.||||||.|.. .. ...    ... . | ..| .|       ....
pelferlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieq

KEQYIYIHKSLADHIQC
 |||..|.. | .... 
leqyefilealleylkf

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1962-2113 2.2e-18 61.0 In-house 124-273 (301) alignment
Range on Protein: 1962-2113
Range on HMM: 124-273/301.0
KITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEE-VHCWYTKRQLLITKDDDSM-SMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppkgPPLVV
|.    .||..| | |..|. ...   |  ...|  ..   .||.| ..   . . . ..|||| . |.|.|||  .. .  ... .. ..     |.||
kvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivv

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYI
|||||.||. .||  . . .... ..|... . | ..|..| . |||..|  ..
hcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1964-2120 6.6e-18 59.5 In-house 116-276 (287) alignment
Range on Protein: 1964-2120
Range on HMM: 116-276/287.0
TTDSNKCAQYWPEKvNETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNI----RLTHP-PKGPPLV
    .|| .||||. .   ..    ..  . .  .  |. | | . . .   .  .  ..|  |||....   . .| |. ..     |.    .  |||
eearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlv

VHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADH
||...|.||.|... . ....|...   ...   ....| .| .|||.  |. .. ..|. .
vhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1967-2118 8e-18 59.5 In-house 121-268 (288) alignment
Range on Protein: 1967-2118
Range on HMM: 121-268/288.0
SNKCAQYWPEKVNETHKLDDG-IIIRTKTEEVHCWYTKRQLLITKDDDSMSmAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPpkgpPLVVHCSAGV
 .| |.|.| |. |. ..     ... | ....   .   | |.|  .     . .  |  |.|.||| . .  . ... .. ..     |.|||.||||
keksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGv

GRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
|||||.|.|  .|. .. .. | |  .| . | .|   .||. ||.|.|. . 
Grtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1966-2127 1.1e-17 58.8 In-house 120-282 (312) alignment
Range on Protein: 1966-2127
Range on HMM: 120-282/312.0
DSNKCAQYWPEKVNETHkLDDGIIIRTKTEEVH------CWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppkgPPLVV
 |.|||.|  . |   . |.|  .      |.          |.| | .          . ||| . |||||.|        ..  ..  .     |.. 
gsekcakyisdivgfvd.ledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpvia

HCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGETS
|||||||||||...|..|.  ...    |. | .. .|..|   |..  ||.|  ... . . .    
hcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly

subfamily_CG42327_pd Subfamily CG42327 2171-2310 1.1e-17 58.7 In-house 23-172 (319) alignment
Range on Protein: 2171-2310
Range on HMM: 23-172/319.0
SIAMDNQERNRFDYNLPYNHTRVILR----DTENDYINASWVEGYKT-GNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLH---PVGTDEIPQFWPPQM
 . .  ....|.   .|  .|||.|.    | .. |..||.| ||.   | .| .|..|... .||| .. .|.  ||| |      | .  ....|.. 
evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke

GQ--AKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYkKWN
.    . | |. |     . .. | | || ||  ..| . ..| |.| || 
tldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1963-2120 2e-17 57.8 In-house 116-268 (281) alignment
Range on Protein: 1963-2120
Range on HMM: 116-268/281.0
ITTDSNKCAQYWPEKVNETHKLDDgIIIRTKTEEVHCWYTKRQLLITKDDDsmSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHppkgPPLVVHCS
. |. .|||.|.| .     ..|  . .  .   |       .| .. . .  .  |||.    |||  ||    ||.  . .||        | |.|||
letnrekcaeyfprnahcclqfdk.lsvsyedstvnkslvttrlnlsyege..trlithwlwkewpdwqvpessevmlkilrkirars....tppvihcs

AGVGRTGTFIVIDTMLQRMKQENTLN-IYDFLLQIRH-QRITLVQTKEQYIYIHKSLADH
|||||.||.. ..  || ..   ||  | . . ..|   | . ||| .||. | | | | 
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2176-2406 2.3e-17 57.9 In-house 35-274 (285) alignment
Range on Protein: 2176-2406
Range on HMM: 35-274/285.0
NQERNRFDYNLPYNHTRVILRDTENDYINASWVE-GYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLL---HPVGTDEIPQFWPPQMGQAKKYQDL
| . ||.      . |||.|.. . ||| |||.    |  . .| || || .| .||| ||.|.. . ...|      | ..   ..| ..|.  |.   
npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

TVEHSLEKEENDYQIITLELKFKN-ESAHNVTLYYYK---KWNINTNNKPYLKPLFGILAK-NQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEG
 .  .  |||     |   |   | | | .  ||  .    |  .       .|.  .    ....  ..||.| |. ||| . ||.       |   . 
eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenp

VSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAEGML
  .... .|. |. |   |.   .... . .| ||  |  
niemldivremramrfqavqshmqflflyvvlmeyfigeg

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2169-2309 5.7e-17 56.5 In-house 24-174 (297) alignment
Range on Protein: 2169-2309
Range on HMM: 24-174/297.0
SCSIAMDN--QERNRFDYNLPYNHTRVILRD--TENDYINASWVEG--YKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLL---HPVGTDEIPQFWP
| | |  |    .||.   | .. ||| |.   ||.||||| .|     ..   .|..| ||..|  ||||.. .|.  |||..      | |    .||
sfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

PQMGQAKKYQDLTVEHSLEKEENdYQ---IITLELKFKNESAHnVTLYYYKKW
   .. .|  |. ||.  .  .. ..   .  |.| ...|| . |.   .  |
svvqerlkagdvvveflsstsde.fdrviltelqliyrsesrv.vrhvqflsw

0049260 (Phosphotyrosine protein) phosphatases II 2208-2396 1.1e-16 56.3 In-house 2-144 (152) alignment
Range on Protein: 2208-2396
Range on HMM: 2-144/152.0
VEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWppqmgqakkyqdltvehslekeendyqiitlelkfknesahnvtly
..||. .. || || |. ||  ||| |........|| |     .     .| .                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

YYKKWNINTNNKPYLKPLFGILAKNQ---LENGNRPIVVACNDGVGCSGTFLTAYSQIerakteGVSDIFQFIRKARSQRPGLVDCLERYIYCHE
 |. ...  .. | |  |. .| .     ... . |..| |  ||| .||.  ||  .         .......  |..||| |   . .....|
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

PTPc_DSPc_SM00012 2301-2398 1.7e-16 55.7 In-house 2-103 (105) alignment
Range on Protein: 2301-2398
Range on HMM: 2-103/105.0
VTLYYYKKWNINTNN---KPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTE-GVSDIFQFIRKARSQRPGLVDCLERYIYCHE
|. |.|..|         .. |. |  .  ... .. . |.|| | .||| .||| ...  ... ..| .  ||||.... |.||||.|. .| |.....
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

LL
 |
al

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2167-2357 2.6e-16 54.2 In-house 41-236 (301) alignment
Range on Protein: 2167-2357
Range on HMM: 41-236/301.0
TISCSIAMDNQERNRFDYNlPYN-HTRV-ILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV---GTDEIPQFWPPQ
 |  | |  .....|..   | . .| | .. | .   | | |..     . ||.|| ||.||. |||.|. | .   ||.|       ..   .. | .
hitesyaylpkdkhryptv.PckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvk

MGQAKKYQDLTVEHSLEKEENDYQIITLELKFK----NESAHNVTLYYYKKWNINTNNKPYLKpLFGILakNQLENGNRPIVVACNDGVGCSGTFLTAYS
...  . .  ...   ..   . .|.  .|. .    . ... || | |..|  .   | . . || ..  . . . ..|||| |..|.| | .|...  
isekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshae.lfdlm..elvkksekPivvhcsaGiGrsvafigtey





0051082 (Phosphotyrosine protein) phosphatases II 2200-2397 2.8e-16 55.0 In-house 3-148 (151) alignment
Range on Protein: 2200-2397
Range on HMM: 3-148/151.0
NDYINASWVEGYktgnwFIVTQIPLQntqtDFWTMIHQQNCSVIVLLHPVG-TDEIPQFWPPQMgqakkyqdltvehslekeendyqiitlelkfknesa
.||||.|.|.|.     ..... ||.    ||. .........|| | .   ..  |...| .                                     
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg....................................

HNVTLYYYKKWNINtnNKPYLKPLFGILAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERaktegvSDIFQFIRKARSQRPGLVDCLERYIYCHEL
..|. ...  |     . | . . .  . .  |...| |..| |. |.| .||.  .|  ...       .... ..  |..|||.|   . .....  
ievlhipildwpdp..glplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1963-2113 5.1e-16 53.0 In-house 126-280 (302) alignment
Range on Protein: 1963-2113
Range on HMM: 126-280/302.0
ITTDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEVHCWYT-KRQLL-----I--TKDDDSMSMAITHYQLTVWPDHGVPVDKIVMisfIDNIRLTHPPKG
.  . .|||.|. .||... |.    .   . ..    .| |...      |  .|  . . ...   . . ||||| | .       .| ..     | 
vedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeayta...ldilkfcesykk

PpLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYI
  ..||||||||||||.. |   .|  ..... .. . .| .|. |   ||...| ||.
n.vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1942-2117 1.8e-15 51.5 In-house 164-340 (350) alignment
Range on Protein: 1942-2117
Range on HMM: 164-340/350.0
SRRKNPTKTEEAVeLYSYITKITTDSNKCAQywpEKVNETHKLDDGIIIRTKTEevhcwytkrqllitkdddsmSMAITHYQLTVWPDHGVPVDKIVMIS
|...|.. ..... |||   |...  |   .   .. .  .. .   |  . ..                     . . . |.  |.| .. .. . ...
skwenimgindss.lysadvkkeasdndnis...ddndlkdnnsltaitlaasd....................PyvvyqlqvknWkDlslllnPesilq

FID-------NI---RLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQ-----RMKQE--------NTL--NIYDFLLQIRHQRITLVQTKEQYIYIHKS
 ..       .       .  ...|..||||||||||||.. .| .|.     .. ..        . .   |   ....|.||| .||...|.|.|...
alevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYea

L
|
l

0044763 (Phosphotyrosine protein) phosphatases II 2187-2397 3.3e-15 51.6 In-house 1-166 (178) alignment
Range on Protein: 2187-2397
Range on HMM: 1-166/178.0
PYNHTRVILRDTEN----DYINASWVEGYktgnwFIVTQIPLqntqTDFWTMIHQQNCSVIVLLHPVGT---DEIPQFWPPQMGqakkyqdltvehslek
|. .|||.|   |.    ||||||.. ..     ..... |      |.. .........|| | .       . .. || ..|                
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

eendyqiitlelkfknesahnvtlYYYKKWNINTNNKPY----LKPLFGILAKNQlENGNRPIVVACNDGVGCSGTFLTAYSQIERakteGVsDIFQFIR
                        . |....|  .. |     .  .. .. . . .. ..|..| |. ||| |||.  ||  ...    |. .... |.
........................iqylhipipDhgvpdllehflefvefieeal.dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaie

KARSQRPgLVDCLERYIYCHEL
  |..||  |   . . ...|.
lvrerRp.ivpnpgqlrqLyef

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2178-2401 3.7e-15 50.3 In-house 57-288 (305) alignment
Range on Protein: 2178-2401
Range on HMM: 57-288/305.0
ERNRFDyNLPYNHTRVIL--RDTENDYINASWVEGYKT-GNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLH---PVGTDEIPQFWPPQMGQAKKYQDL
 .||.. ..| .   ...  . .  ||| | .|       . ||..| ||..|  .|| |. |..   ||.|     .|     |.||  .|. .. .  
tknryq.dvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksg

T-VEHS-LE---KEENDYQIITLELKFKNESAHNVTLYYYKKWNINTNNKPYLKPLfGILakNQLENGNRPIVVACNDGVGCSGTFLTAYSQIER-AKTE
  ||        . ... || .|.| .  .    |    . .|         |  |  .|    .   . |||| |  |.| .|| ..    .|. |.  
ivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltsl.ell..sairgskvpivvhcsagigrtgtivaieyilekiaenk

GVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEY
 .  . ....  | ||   ..   .|.. | .. .|
pcppmpelvkalrdqrafsiqndvqylfihrvmlny

subfamily_CG42327_pd Subfamily CG42327 2054-2118 1.5e-14 48.4 In-house 247-312 (319) alignment
Range on Protein: 2054-2118
Range on HMM: 247-312/319.0
GPPLVVHCSAGVGRTGTFIVIDTMLQRMKQE-NTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
  ||||||| ||||||. |  |  ......  ....| . . ..|..|   |.||||| .|.| | 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1965-2112 3.7e-14 47.4 In-house 65-212 (255) alignment
Range on Protein: 1965-2112
Range on HMM: 65-212/255.0
TDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEvHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFidnIRLTHppKGPPLVVHCSAG
 . .|| .|.| . .|  || |  .. ||.   .     .... |  .      ..||. . |...  | .   .      ... .  .  ..|||||.|
egvekcssyfplekdeklkladvnvtttkssa.dvvlrtleitstlgekkkthtvkhysykGWieknaPelareilni...lkvvr..dsksvvvhCstG

VGRTGTFIVIDTMLQ----RMKQENTLNI--YDFLLQIRHQRITLVQTKEQYIY
.||. .|.... . |     ... .| ..    .| ..|..| . ..|  |  .
iGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2176-2402 5e-14 46.6 In-house 37-269 (281) alignment
Range on Protein: 2176-2402
Range on HMM: 37-269/281.0
NQERNRFDyNLP-YNHTRVILRD-----TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPV---GTDEIPQFWPPQMGQAK
|...||.  |.|  . .|| |.         ||| | ..        .|.|| | ..|..||| || |.| . ||.|  .     ..  ...| .   . 
nnkknryl.nipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahccl

KYQDLTVEHSLEKEENDYQIITLELKFKNESaHNVTLYYYKKWNINTNNKpYLKPLFGILAKnqLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTE-
... |.|..     ..      |.| .. |. . .| . .|.|      .   . .. || |  .     | |. |  ||| |||...    ..  ..  
qfdklsvsyedstvnkslvttrlnlsyeget.rlithwlwkewpdwqvpe.ssevmlkilrk..irarstppvihcsagvgrsgtlmaveialqsihshf

GVSDIFQFIRKARS-QRPGLVDCLERYIYCHELLCEYA
 . || | . . |   |   |. |..|.   ..| .. 
tlpdikqivshlrvtgraasvqtlqqymliwkvlldfg

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2188-2379 9.3e-14 46.2 In-house 30-239 (290) alignment
Range on Protein: 2188-2379
Range on HMM: 30-239/290.0
YNHTRVILRDT----ENDYINASWVEgYKTGNWFIVTQIPLQNT-------QTDFWTMIHQQNCSVIVLLHPVGTDE-------IPQFWPPQMGQAKKYQ
 ..|||.|..      .||| |. |  .  |  .|.|| |....         .|| |..| .   .| |  .   .         .. | ..|.  |..
veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

DLTVEHSLEKEENDYQIITLELKFKNESAHNVTLYYYKKWNINtNNKPYLKpLFGILAkNQLENGNRPIVVACNDGVGCSGTFL---TAYSQIE-RAKTE
.|||.     .|.| .. .|..|| .|  . || . .| ||   | ..  | ..  |. ..... . |..| | ||.  | ..     .|  |    .  
gltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnkl.nvqedtk.tllsli.qkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv

GVSDIFQFIRKARS
 . |. . .|| | 
kledvlkalrkqra

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2057-2124 1e-13 45.5 In-house 1-68 (69) alignment
Range on Protein: 2057-2124
Range on HMM: 1-68/69.0
LVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCG
.|||||.| ||||||| |   . |.| |  ..|.. .  .|  |  .|  . .||.|| .|.. .. |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2138-2403 1.2e-13 45.5 In-house 11-288 (305) alignment
Range on Protein: 2138-2403
Range on HMM: 11-288/305.0
KELRKKNEDEECEFQKEFELLKELSDTTSTISCSIAmDNQERNRFDYNLPYNHTRVILRDT-ENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIH
| ...  |     ...||  .| . |     .   | .....||.      .. || |. .   .|| | .|      . || || ||..| .||| |  
kfvkrtlekgpaglraefvamkrfndfekmkafkea.qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymcl

QQNCSVIVLLHP---VGTDEIPQFWPPQMG----QAKKYQDLTVEHSLE-----KEENDYQIITLEL--KFKNESAHNVTLYYYKKWNINTNNkPYLKPL
|..   | .|      |.    .... . .      .| | ..|          ... . ..   .|  .   |.|. || |..  |       .    .
qdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvp.aadlai

FGILAKNQLENGnrPIVVACNDGVGCSGTFLTA-YSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
. .|.| .   |  |||| |  |.| .|. .   |   .    . . |  . ..| | ||   ..  ..|.. |... .| .
lellekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2166-2310 1.5e-13 44.9 In-house 86-231 (244) alignment
Range on Protein: 2166-2310
Range on HMM: 86-231/244.0
STISCSIAMDNQERNRFDYNLPYNHTRVILRD--TENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVgtDEIPQFWPPQMG
| .  ..  .|  .||    ||..  || |      | |||||.|        .|.|| || .|  ||| |. ..   |.|.|  |  .|  ..||    
svmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsv..eeedeywpdsep

QAKKYQDLTVEHSLEKEENDYQIITLELKF-KNESAHNVTLYYYKKWN
     .|.||  .   |  . .   ||..   |||   .|..   .| 
lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwp

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2214-2394 1.7e-13 45.2 In-house 4-196 (199) alignment
Range on Protein: 2214-2394
Range on HMM: 4-196/199.0
GNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTD---EIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFK---NESAHNVTLYYYK
   .|.|| ||..| .||| |. .     ||..     .   . | .||     . ||  |.|       . || | .| |  .     |. ... | . 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

KWNINTNNKPYLKPLFGIL----AKNQLENGNRPIVVACNDGVGCSGTFLTAYS---QIERAKTeGVSDIFQFIRKARSQRPGLVDCLERYIYC
 |. .|  .  |   | .     .|.  .. . |..| | || | .| |..        | .||  | |.|.  .. |  | |..  |. | . 
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfi

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2208-2309 1.8e-13 44.7 In-house 229-328 (440) alignment
Range on Protein: 2208-2309
Range on HMM: 229-328/440.0
VEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDEIPQFWPPQmGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNEsAHNVTLYYYK
.|||   | || ||.||. |  ||| ..|. . | |..|  .       .|| .  ..  .  .|| |   .. |  .. |||||.|.|  |..  .  .
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvn.trsvtfgpftvghkgsenmnrvkvrtlelkykee.vheirqfevq

KW
 |
tw

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2216-2394 2e-13 45.0 In-house 5-195 (198) alignment
Range on Protein: 2216-2394
Range on HMM: 5-195/198.0
WFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTD---EIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFK---NESAHNVTLYYYKKW
 .|.|| ||..| .||| |. .     ||..     .   . | .||     . ||  |.|       . || | .| |  .     |. ... | .  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

NINTNNKPYLKPLFGIL----AKNQLENGNRPIVVACNDGVGCSGTFLTAYS---QIERAKTeGVSDIFQFIRKARSQRPGLVDCLERYIYC
. .|  .  |   | .     .|.  .. . |..| | || | .| |..        | .||  | |.|.  .. |  | |..  |. | . 
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfi

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2058-2124 2.1e-13 44.4 In-house 1-67 (69) alignment
Range on Protein: 2058-2124
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCG
|||||.| ||||||| |   . |.| |  ..|.. .  .|  |  .|  ...|..|| .|.. .. |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

fn3 Fibronectin type III domain 1533-1618 2.3e-13 43.2 Pfam-A 6-84 (85) alignment
Range on Protein: 1533-1618
Range on HMM: 6-84/85.0
FETYNITAYEMTFTWLPPLecFRNGDIIKYSLSCSFNNATHsdiqqSLQHQITSKRENRFTLHNLYPFTNYTCHLAAANGIGEGPA
.   ..|. ..|..| ||    ..|.| .|.. ..  . ..       ... ... ....||..| | |.|.. ..| || ||||.
lsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

subfamily_hpo-7_pd Subfamily hpo-7 1965-2112 4e-13 43.9 In-house 71-218 (263) alignment
Range on Protein: 1965-2112
Range on HMM: 71-218/263.0
TDSNKCAQYWPEKVNETHKLDDGIIIRTKTEEvHCWYTKRQLLITKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLThppKgpPLVVHCSAG
 . .|| .|.| . .|  || .  .  ||. .       ..|| | ..      ..||. . |...  | . . ..  ..  |     |  .||||||.|
egvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvarns...k..slvvhcstG

VGRTGTFIVIDTMLQ----RMKQENTLNI--YDFLLQIRHQRITLVQTKEQYIY
.||.  | |.... |     ... .| ..    .| ..|..| . ..|  |  .
iGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf

fn3 Fibronectin type III domain 1632-1708 5.9e-13 42.0 Pfam-A 1-84 (85) alignment
Range on Protein: 1632-1708
Range on HMM: 1-84/85.0
SEPENLTIISTSSSSLVLTWSKPIQPNGIIVKYTINCS---SGI-FDNETIDNI---VVLNGLVPYTNYTCSVSAHTRIGVGPA
|.||||......|.||.|.||.| ...| |..|.. ..   .|    . |...    |.|.|| |.|.|...| |... | ||.
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

subfamily_PTPN9_pd Subfamily PTPN9 2331-2403 5.9e-13 43.5 In-house 219-291 (297) alignment
Range on Protein: 2331-2403
Range on HMM: 219-291/297.0
LENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCEYAE
 .  . |||| |  |.| .||| |    ..| ...|. |... ... |.||   .   |.| .|.  . ||| 
ghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2174-2294 1.2e-12 42.1 In-house 50-174 (310) alignment
Range on Protein: 2174-2294
Range on HMM: 50-174/310.0
MDNQERNRFDYNLPYNHTRVILR---DTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDEIPQ---FWPpQMGQAKK
 ..  .||.   .  . .|| |.      .||| | .|      . ||..| ||| |  ||| || |. .  |.||  || .  |.   .||  .| .. 
kkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp.slgvtet

YQDLTVEHsLEKEENDYQIITLELKFK
|  . |   | .  ....|  | . | 
ygcirvtn.lsesseefeicnlavtfv

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2009-2121 4.1e-12 40.1 In-house 173-285 (302) alignment
Range on Protein: 2009-2121
Range on HMM: 173-285/302.0
TKDDDSMSMAITHYQLTVWPDHGVPVDKIVMISFIDNIRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKE
  .. | |. .. | || |... |||    .|  . ..   . .   ..|.    |.|| |.|..  . ........  || . . .|| || . |.. .
lPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslk

QYIYIHKSLADHI
||. .. .|. .|
Qyvslyialllyi

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2161-2247 5.9e-12 39.8 In-house 32-115 (303) alignment
Range on Protein: 2161-2247
Range on HMM: 32-115/303.0
LSDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTenDYINASWVEgYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLH
 |    ..|    ..| ..|||   .  .|..| | |.   || ||..|  .. .  |.||.||. | .||| || .|.  ...|| 
vsylppsvsknqfvknmdknrfvdvicldhskvklsds..syihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvllll

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2023-2118 2.5e-11 37.7 In-house 196-287 (310) alignment
Range on Protein: 2023-2118
Range on HMM: 196-287/310.0
QLTVWPDHGVPVDKIVMISFidniRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
.   ||| ||| .|   .      ||    .  | |||||||..|... . ..  ...... . ... .   .....|.  .||. ||..|..   
kwpnwpdrgvpdekchtvpq....rllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2171-2258 4.3e-11 37.1 In-house 42-150 (350) alignment
Range on Protein: 2171-2258
Range on HMM: 42-150/350.0
SIAMDNQERNRFDYNLPYNHTRVILR------------DTENDYINASWVEGY-----KTGNW-FIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTD
|  ..   .||.   |||.|.||.|.               ||||||....          .. .| || ||..|  ||...| . .  ||. | .    
seGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel

---EIPQFW
    . ..|
nlekcyrYW

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2186-2310 3.4e-10 34.3 In-house 3-122 (130) alignment
Range on Protein: 2186-2310
Range on HMM: 3-122/130.0
LPYNHTRVIlrdtENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLHPVgtDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQ
|... .|.     .|.|||||.|      . .. || || .| .||| |. ..   |.|.|  |  .|  ..||         .|..|  .  .| .  .
lefevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsv..eeedeywpdsePlewyeediivtltdrdefknik

IITLELKFK-NESAHNVTLYYYKKWN
   || . . ||| . .|..   .| 
asnleiesdlneshqaltmfqisnwp

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1971-2114 4.8e-10 33.9 In-house 48-197 (199) alignment
Range on Protein: 1971-2114
Range on HMM: 48-197/199.0
AQYWPEKVNETHKLDdGIIIRTKTEEVHCWYTKRQLLITKDDDS--MSMAITHYQLTVWPDHGVPVDkIVMISFIDNIRL----THPPKGPPLVVHCSAG
. |||   . | |    . . |||  ..  ||   |..|..  .   .  |.|||.| | ..  |    ... |.   |         |  |..|||| |
pfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdg

VGRTGTFIVIDTMLQRMKQENT--LNIYDFLLQIRHQRITLVQTKEQYIYIH
 | || |. .|  ..  .. .|  .....   ..|  |  .. . ..| .|.
qgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1971-2114 4.8e-10 34.0 In-house 47-196 (198) alignment
Range on Protein: 1971-2114
Range on HMM: 47-196/198.0
AQYWPEKVNETHKLDdGIIIRTKTEEVHCWYTKRQLLITKDDDS--MSMAITHYQLTVWPDHGVPVDkIVMISFIDNIRL----THPPKGPPLVVHCSAG
. |||   . | |    . . |||  ..  ||   |..|..  .   .  |.|||.| | ..  |    ... |.   |         |  |..|||| |
pfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdg

VGRTGTFIVIDTMLQRMKQENT--LNIYDFLLQIRHQRITLVQTKEQYIYIH
 | || |. .|  ..  .. .|  .....   ..|  |  .. . ..| .|.
qgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_eak_pd Subfamily eak 2165-2312 6.6e-10 32.9 In-house 41-192 (332) alignment
Range on Protein: 2165-2312
Range on HMM: 41-192/332.0
TSTISCSIAMDNQERNrFDYNLPYNHTRVILRDTE---NDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVL-LHPV--GTDEIPQFW
  .|| .  ... .||     .||..  | |  .    . ||||| .|  . |. .|.| |. ..    || |. .|.   ||  |. |  . ..  ...
llsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFKNEsAHNVTLYYYKKWNIN
| .  .  |.  | ||     ..| ..   |||.  || .|.|  | .  |   
pdktreelkfGildverkefvkrniletrllelskGne.thrvlhykvfGwtet

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2303-2400 8.5e-10 32.5 In-house 93-192 (440) alignment
Range on Protein: 2303-2400
Range on HMM: 93-192/440.0
LYYYKKWNINTNN---KPYLKPLFGiLAKNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLC
 |.|. |  .       | || .   . ..| . || |..| |. |.| .|  ..  | .  ||     ||| ||   |..|| .|.. |.| . || . 
qyhyqgwpdkgvpkfagpvlkmiqd.vnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavl

E
|
e

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2146-2221 1.2e-09 32.2 In-house 20-94 (95) alignment
Range on Protein: 2146-2221
Range on HMM: 20-94/95.0
DEECEFQKEFELLKELSDTTSTISCSIAmdNQERNRFDYNLPYNHTRVILRD-TENDYINASWVEGYKTGNWFIVTQ
. . ||..||  .   | .. |.  | |  |  .|||   .||. |||.|    . ||||| .|.||   | .| .|
nsdqefdnefksismtsgapytvgssea..nipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq

subfamily_eak_pd Subfamily eak 2037-2125 1.5e-09 31.7 In-house 221-309 (332) alignment
Range on Protein: 2037-2125
Range on HMM: 221-309/332.0
IVMISFIDNIRLThPPKGPPlVVHCSAGVGRTGTFIVIDTMLQRM--KQENTLNIYDFLLQIRHQRITLVQTKEQYIYIHKSLADHIQCGE
 .. |.. .   | ||   | .. .. |  |.|.|.||| ... .  |..|.  . |..|.....||  | .. |. .|.. . |...  .
allsstlkkyiht.ppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn

0048076 (Phosphotyrosine protein) phosphatases II 2278-2400 2.9e-09 32.3 In-house 25-141 (145) alignment
Range on Protein: 2278-2400
Range on HMM: 25-141/145.0
EKEENDYQIITLELKFKNESAHNVTLYYYKKWNINTNNK-PYLKPLFGILAKNQLENgnRPIVVACNDGVGCSGTFLTAYSQIEraktEGvSDIFQFIRK
 |. . . ...|   ............|.  .  .. .   .|  .. .. . . |.  .|..| |. ||| .||.  ||  ..    .|  .... ...
lkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealel

ARSQRPGLVDCLERYIYCHELLCE
 |||||| |   . .....|.. |
vrsqrpgavpnpgqlrflyefele

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2173-2246 4.3e-09 30.3 In-house 31-107 (332) alignment
Range on Protein: 2173-2246
Range on HMM: 31-107/332.0
AMDNQERNRFDYNLPYNHTRVIL--RDTENDYINASWVEGYKTGNWFIVTQIPLQN-TQTDFWTMIHQQNCSVIVLL
 ..| . ||  .   ..|.|| |  .| ..|. |||||.||   . .|..| |... |.  || |. ... |.|...
flnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf

subfamily_CG42327_pd Subfamily CG42327 1968-2047 4.6e-09 30.4 In-house 112-191 (319) alignment
Range on Protein: 1968-2047
Range on HMM: 112-191/319.0
NKCAQYWPEKV-NETHKLDDGIIIRTKTEEVHCWYTKRQLLITKDDDSMSMAITHYQLtVWPDHGVPVDKIVMISFIDNIR
..||.|.| |   . ..|   | .  |  ||.  |    ||. . |...|  .|||    |.. .|| ..  .|. . ..|
kvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2227-2383 5e-09 30.6 In-house 40-202 (255) alignment
Range on Protein: 2227-2383
Range on HMM: 40-202/255.0
TQTDFWTMIHQQNCSVIVLLHPV---GTDEIPQFWPPQMGQAKKYQDLTVEHSLEKEENDYQIITLELKFK-NESAHNVTLYYYKKWnInTNNKPYLKPl
|   |. .| |.. .|.|.|      | ..  ...| .  . .|..|..|  .    .   . ... ...     .|.|. | || | |  .| | |   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGW.i.eknaPelar.

fGILAKNQLENGNRPIVVACNDGVGCSGTFLTA---YS----QIERAKTEGVsDIFQFIRKARSQRPG
  ||   ..    ...|| |. |.| | .|  |   |     ......| .. |  ..... ||.|..
.eilnilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetvel.dylslleelrskrkr

I-set Immunoglobulin I-set domain 578-656 5.2e-09 27.8 Pfam-A 11-88 (90) alignment
Range on Protein: 578-656
Range on HMM: 11-88/90.0
TVNIECTIILNTPVGPGIQPNVTWYYDATDITLSGSLLRNNDIvFISTLTIDSIQVSDAGVYHCNAGIDSNVTTSNISV
.|... .. |.  |    .|.|.|. | .... | ..  ...   ..||||....|||.| |.|.|   .   ......
evseGesvelectveGepepsvsWakdgselkssqrvkvtvee.aeytLtIsnvevsDeGkYtckatnsagkaeakaeL

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2006-2138 6.7e-09 29.8 In-house 162-297 (303) alignment
Range on Protein: 2006-2138
Range on HMM: 162-297/303.0
LLITKDDDSMSMAITHYQltVWPDHGVPVD---KIVMISFIDNIRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRMKQE-NTLNIYDFLLQIRHQRI
| ... |    . . ||.   ||   .| |   |.|   .  .  | .  .. | |    .|.||.||| ...|    ...| ..|..   | ..|  |.
lsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrl

TLVQTKEQYIYIHKSLADHIQ-CGETSFAIEKAQYRIK
  ||   |. ...  ||.|.   | . .|| |     |
havqnlsqfsvvytllaehvldngicklaipkkpndek

subfamily_ptpA1_pd Subfamily ptpA1 1997-2081 9.9e-09 29.4 In-house 162-256 (418) alignment
Range on Protein: 1997-2081
Range on HMM: 162-256/418.0
VHCWYTKRQLLITKD----DDSMSMAITHYQLTVWPDHGVPVDKIVM------ISFIDNIRLTHPPKGPPLVVHCSAGVGRTGTFIVIDTMLQRM
|       . .||..     .  .  ||.||   |||| .|     .      |.  .|  .    .  |..|||||||||||||     |....
veviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2338-2400 3.4e-08 27.8 In-house 1-63 (69) alignment
Range on Protein: 2338-2400
Range on HMM: 1-63/69.0
IVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
.|| |  | | .|||..   .. | |.| . |||  ..  |  || .|     ||. |. | |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve

0048179 (Phosphotyrosine protein) phosphatases II 2309-2396 7.3e-08 27.8 In-house 55-139 (144) alignment
Range on Protein: 2309-2396
Range on HMM: 55-139/144.0
WNINTNNKP----YLKPLFGILAKNqLEnGNRPIVVACNDGVGCSGTFLTAYsqieRAKTEGvSDIFQFIRKARSQRPGLVDCLERYIYCHE
...  .. |    .|  .. .. .  ||  ..|..| |. ||| .||. .||    . |..|  .... ..  ||.||| |   . .....|
lpwpDhgvpdllellleflefieea.le.eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2339-2400 1.3e-07 25.8 In-house 1-62 (69) alignment
Range on Protein: 2339-2400
Range on HMM: 1-62/69.0
VVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHELLCE
|| |. | | .|||..   .. | |.| . |||  ..  |  || .|   . |.. |. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve

fn3 Fibronectin type III domain 1816-1891 1.4e-07 24.7 Pfam-A 3-82 (85) alignment
Range on Protein: 1816-1891
Range on HMM: 3-82/85.0
PENVTAVWINSTTVKVTWLPLTlaEARGFITRYSV-YA--GNTG-IANVSNDSSI--AYIDSLNPMLQYSISVSASTKVGES
|||...  ..||.. ..| | .  . .| ||.|.| |.  |...   .......   . .  |.|  .|...| | ...||.
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngageg

subfamily_PTPDC1_pd Subfamily PTPDC1 1987-2114 1.4e-07 26.2 In-house 50-169 (182) alignment
Range on Protein: 1987-2114
Range on HMM: 50-169/182.0
GIIIRTKTEEVHCWYTKRQLLITKDDDS-MSMAITHYQlTVWPDHGVP-VDKIVMISFIDNIRLTHppkGpPLVVHCSAGVGRTGTFIVIDTML-QRMKQ
 | ...| |  .| . ...   . | .. |   |..|.   |.|.||. ...|. |  . .  |..   |  . ||| || ||||  |    .  .|.. 
vinLqekgehasCGagleesGfsYdlealmeqgiyvyn.fgwkDygvasleriLdivkvvafalqe...g.kvavhChaGlGrtGvliacylvyakrlta

ENTLNiydfllQIRHQRITLVQTKEQYIYIH
|....       .|..|   .||.||   ..
ekaik......lvrskrpksiqtreqvelvk

0038934 (Phosphotyrosine protein) phosphatases II 2024-2074 1.6e-07 26.7 In-house 84-135 (194) alignment
Range on Protein: 2024-2074
Range on HMM: 84-135/194.0
LTVWPDHGVPVDKIVMISFIDNIRLTHPP-KGPPLVVHCSAGVGRTGTFIVI
   .||.|.. .  .. .|.| .   .   .|   .||| ||.|||||... 
klpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

Ig_2 Immunoglobulin domain 772-857 2e-07 22.9 Pfam-A 11-75 (80) alignment
Range on Protein: 772-857
Range on HMM: 11-75/80.0
LAITSSVMLNCTISlntgiG-PDTSFIshyWYQYNTDISDRSTPlmingdskslvI-IlniTNIQPSDAGEYQCRASIDGNdTIISNL
.   ..| |.|...     | |.....   ||. .. .| .              . |    |....|.| |.|||| ..   . || 
vtegenvtLtCqap.....gnptpkvq...wykdgeelsqsqna...........lfi...pnvsaedsGtYtCrasnseg.skqsns

Ig_2 Immunoglobulin domain 1215-1294 2.1e-07 22.9 Pfam-A 8-68 (80) alignment
Range on Protein: 1215-1294
Range on HMM: 8-68/80.0
PdeQYYDVGSNVTLTCSVNypppdshidV----StslnISLFLGDdTLIRQSFTNIITyelNNLQLRDATLYTCSYfissDNDS
|  .... |.||||||...              .    ... ... ... ||  ....   .|... |.  |||..     |..
p..tvvtegenvtLtCqap.........gnptpk....vqwykdg.eelsqsqnalfi...pnvsaedsGtYtCra....snse

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2192-2258 2.2e-07 24.7 In-house 62-129 (347) alignment
Range on Protein: 2192-2258
Range on HMM: 62-129/347.0
RVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCS-VIVLLHPVGTDEIPQFW
.    |  . ||||| .   .. . .|.|| || .|  ||| |..  . . |. .. |.  . | .| 
knsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaieefa

subfamily_hpo-7_pd Subfamily hpo-7 2226-2382 2.7e-07 24.7 In-house 45-207 (263) alignment
Range on Protein: 2226-2382
Range on HMM: 45-207/263.0
NTQTDFWTMIHQQNCSVIVLLHPVG---TDEIPQFWPPQMGQAKKYQDLTVEHSLEKEenDYQIITLELKF--K-NESAHNVTLYYYKKWnINTNNKPYL
.|   |. .| |.. .|.|.|        ..  ...| .  . .|.....|  .  ..  |  . ||||    .     |.|. | || | |..|.    
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgW.iekndpela

KPLFGILaknQLENGNRPIVVACNDGVGCSGTFLTA---YS----QIERAKTEGVsDIFQFIRKARSQRP
.  . ||   ..  . ...|| |. |.| |  |  |   |     ... ..| .. |  ..... ||.|.
reilnil...kvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstvel.dylsLleelrssrk

Ig_2 Immunoglobulin domain 374-455 4.3e-07 21.9 Pfam-A 9-73 (80) alignment
Range on Protein: 374-455
Range on HMM: 9-73/80.0
SSYIIGEQVLLQCSINltnaiG-PNISslnIKWFKSEEVIRDYimhdlalP-SsvfhssLTIPSVSFNDAGVYNCTASLTGS--QS
...  ||.| | |...     | |. .   ..| | .| .          .        | ||.|| .|.|.| |.||...   ||
tvvtegenvtLtCqap.....gnptpk...vqwykdgeelsqs.......qna......lfipnvsaedsGtYtCrasnsegskqs

I-set Immunoglobulin I-set domain 399-452 6.4e-07 21.1 Pfam-A 28-79 (90) alignment
Range on Protein: 399-452
Range on HMM: 28-79/90.0
SSLNIKWFKSEEVIRDyiMHDLALPSSVFHSSLTIPSVSFNDAGVYNCTASLTG
  ....|.| .. ..    ... .  .  ...||| .|. .|.| |.|.|.   
pepsvsWakdgselks..sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsa

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2220-2394 8.7e-07 22.7 In-house 96-280 (302) alignment
Range on Protein: 2220-2394
Range on HMM: 96-280/302.0
TQIPLQNTQTDFWTMIHQQNCSVIVLLHPVGTDE---IPQFWPPQMGQAKKYQDLTV-----EHSLEK--EENDYQIITLELK---FKNESAHNVTLYYY
  .| ..|.  .|..|.| | ...| |  .  ||   . ...  ..|.  |..  ||     .. ||.  . ..... |.|.|    |..  . | . ..
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

KKWNINTNNKPYlKPLFGILakNQLENGNRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYC
  |      |   .. . ||  .  |   . ..| |  ||| .||...    |.  ... |.|. . .   |. | | |   .. || 
sawpdhGapkea.ytaldil..kfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2162-2247 1e-06 22.7 In-house 29-114 (312) alignment
Range on Protein: 2162-2247
Range on HMM: 29-114/312.0
SDTTSTISCSIAMDNQERNRFDYNLPYNHTRVILRDTENDYINASWVEGYKTGNWFIVTQIPLQNTQTDFWTMIHQQNCSVIVLLH
 .  |   |.  .  .. ||.     ..  |  |   || || | .|      . |..|| ||.|| | || .     .. |.|| 
gnivsdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

subfamily_egg_pd Subfamily egg 1963-2118 1.2e-06 22.4 In-house 116-267 (307) alignment
Range on Protein: 1963-2118
Range on HMM: 116-267/307.0
ITTDSNKCAQYWPEKVNETHKL-DDGIIIRTK--TEEVHCWYTKRQLL-ITKDddSMSMAITHYQLTVWPDHgvpvDkivMISFIDNIRLTHPpKGPPLV
 . .|..|  |||   ... ..   .. | .    ..    ..  .|  .  |     . . |.|  |        |   . | .  .|.       | |
srkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdvnnss....d...vysplrvlrklrn.lskpvv

VHCSAGVGRTGTFIVIDTMLQRMKQENTL--NIYDFLLQIRHQRITLVQTKEQYIYIHKSLA
|..  || ...|.. |.. |  . .  .    .      .| .|   |..  .|..... ..
vqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

ig Immunoglobulin domain 1223-1285 1.6e-06 19.4 Pfam-A 1-63 (64) alignment
Range on Protein: 1223-1285
Range on HMM: 1-63/64.0
GSNVTLTCSVnypppdshIDVSTSLNISLFLGDDTLIRQSFTNIIT--------YELNNLQLRDATLYTCS
||.|||||||         . . | ..|.. ....|.  . |.  .        ...||..  |.. |||.
GssvtLtCsv........ssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCv

Ig_2 Immunoglobulin domain 576-653 1.7e-06 20.0 Pfam-A 14-74 (80) alignment
Range on Protein: 576-653
Range on HMM: 14-74/80.0
SSTVNIECTIIlntpvgpGI-QPNVTWYYDATDITlSGsllRNNdivfistLTIDSIQVSDAGVYHCNAGIDSNVTTSN
...|.. |..        |  .|.|.|| | . .. ..   .|.       | | .....|.|.|.| |  ..  ..||
genvtLtCqap.......gnptpkvqwykdgeels.qs...qna.......lfipnvsaedsGtYtCrasnsegskqsn

Ig_3 Immunoglobulin domain 368-449 2e-06 19.9 Pfam-A 4-74 (75) alignment
Range on Protein: 368-449
Range on HMM: 4-74/75.0
VSIKFNSSYIIGEQVLLQCSINLTNAigpnisSLNIKWFkseevIRDYIMHDLALPSSVFHSSLTIPSVSFNDAGVYNCTAS
.|...... . |. | |.||.  . .      . .| |      |      .    ||  .|.|||.||...| |.| |.||
isvspsptvtsggnvtLtCsaeggpp......pptisWy.....ietppelqgsegssssestLtissvtsedsGtYtCvas

Ig_3 Immunoglobulin domain 285-352 2.1e-06 19.9 Pfam-A 4-75 (75) alignment
Range on Protein: 285-352
Range on HMM: 4-75/75.0
VTISGNYTSLRVGSsTDIECETVPSIPNAVIKWQ------DVSSFNSYSYENVLTIDPVLlSNDNKTFTCVVSS
...| . |   .|.   . |... . |.. | |.      . .| .|.|.|..||| .|  |.|. |.|||.|.
isvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvt.sedsGtYtCvasN

PTEN_1 1974-2072 2.4e-06 22.5 In-house 44-148 (196) alignment
Range on Protein: 1974-2072
Range on HMM: 44-148/196.0
WPEKVNETHKLDD-GIIIRTKTEEVHCWYTKRQLLIT-----KDDDSMSMAITHYQLTvWPDHGVPVDKIVM--ISFIDNIRLTHPPkGPPLVVHCSAGV
..|.... . .|      . | . ......      .      ... . . ......  ..|||.|    ..  .  ... .| .|. |   .||| ||.
ideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfp.ieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGl

GRTGTFI
||.|| .
gRsGtvv

PTPlike_phytase Inositol hexakisphosphate 1949-2078 2.6e-06 22.1 Pfam-A 32-148 (149) alignment
Range on Protein: 1949-2078
Range on HMM: 32-148/149.0
KTEEAVELYSYITKITTDSNKCAQYWPEKVNETHKLDDGIiiRTKTEEV-HcwytkrqlLITKDDDSMSMAITHYQLTVwPDHGVPVDKIVMiSFIDNIR
. .|| ||.   ... .| .| |.    ..   .. ..|.    ...|| .         ... . . .. .. . ... .|.  | .. |  .|.. |.
sgieaeeledlekrlkedvlkeaeeyegrilvhreteegv..qktltevte........evyeeelaegfgvkYvRipi.tdeqapeeedvD.afvrlik

LThpPKGPPLVVHCSAGVGRTGTFIVIDTML
 .  |. . ||..|.|| ||| |..|| ..|
sl..prdtalvfnCqaGrgRTTtamviadLl

PTPlike_phytase Inositol hexakisphosphate 1949-2078 2.6e-06 22.1 In-house 32-148 (149) alignment
Range on Protein: 1949-2078
Range on HMM: 32-148/149.0
KTEEAVELYSYITKITTDSNKCAQYWPEKVNETHKLDDGIiiRTKTEEV-HcwytkrqlLITKDDDSMSMAITHYQLTVwPDHGVPVDKIVMiSFIDNIR
. .|| ||.   ... .| .| |.    ..   .. ..|.    ...|| .         ... . . .. .. . ... .|.  | .. |  .|.. |.
sgieaeeledlekrlkedvlkeaeeyegrilvhreteegv..qktltevte........evyeeelaegfgvkYvRipi.tdeqapeeedvD.afvrlik

LThpPKGPPLVVHCSAGVGRTGTFIVIDTML
 .  |. . ||..|.|| ||| |..|| ..|
sl..prdtalvfnCqaGrgRTTtamviadLl

fn3 Fibronectin type III domain 1423-1510 2.7e-06 20.6 Pfam-A 3-80 (85) alignment
Range on Protein: 1423-1510
Range on HMM: 3-80/85.0
PINMTSVVLNTTSVRIEWVVT-SVTYSPEIYTVHYESLSCYHngsfsingstsVEVFTQESNTPYSLTIDGLKPGIKYTYYIASKNTEG
| |..    ..||....|    .     . |.|.|.. .  .           ...  . ..| .|.|. ||||| .|.. ... |..|
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...........ewkeftvprtttsvtltgLkpgteYefrVqavngag

Ig_3 Immunoglobulin domain 770-846 3.8e-06 19.0 Pfam-A 17-74 (75) alignment
Range on Protein: 770-846
Range on HMM: 17-74/75.0
LllaitssVMLNCTISLNTGigpdtsFISHYWYqyntdiSDRSTPLMINGDSKSLVIILNITNIQPSDAGEYQCRAS
        | |.|..  . .        ...||       . .  |  ...|.|   .|.|.. ...| | |.| ||
n.......vtLtCsaeggpp......pptisWy......ietppelqgsegssssestLtissvtsedsGtYtCvas

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2335-2397 8e-06 19.9 In-house 228-290 (297) alignment
Range on Protein: 2335-2397
Range on HMM: 228-290/297.0
NRPIVVACNDGVGCSGTFLTAYSQIERAKTEGVSDIFQFIRKARSQRPGLVDCLERYIYCHEL
| ...| |  ||| ||  . .   ... . . . |.  .... |.||. ||  ||.. .....
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda

subfamily_PTEN_pd Subfamily PTEN 2057-2114 8.6e-06 20.8 In-house 117-175 (184) alignment
Range on Protein: 2057-2114
Range on HMM: 117-175/184.0
LVVHCSAGVGRTGTFIVIdTMLQRMKQENTLNIYDFLLQIRHQRITLVQTKEQYIYI--H
 |||| || ||||. ||   .|.... |.. .. ..  ..| .  . |.   |  |.  .
vvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYy