Gene PTPRD-61 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP119_AA protein Get Run
AqueP119_AA_1-154 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2-161 1.4e-87 288.2 In-house 126-301 (301) alignment 
Range on Protein: 2-161
Range on HMM: 126-301/301.0
CCYQYWRESEIVQFGEYFVKCLLSKDC-------------------NGYIERKLHIRSDKndsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQ
.|.|||..||  .  .......|....                   |||||||....|||   |||||.|.|||.||.|||.||||||||||||||||||
kceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqq

KIGGGPVVVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHSTYAN
|||||||||||||||||||||||||..|||||||||||||||||.||||||||||||.||.|||..|.|||.|.|||||
kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-155 1.7e-58 193.2 In-house 129-285 (305) alignment 
Range on Protein: 1-155
Range on HMM: 129-285/305.0
ECCYQYWRESEIV--QFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVS
..|.||| ||.    .|||. |.   .|  ..||||||.|  ...|. |  |.|.|.|.|| .|| ... ..|..|..| ..|.|  | |..||||..|.
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvg

RSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKL
|.||...|..|||..|.|.|||||.|.| .|......|.||||| ....|.  ... 
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-159 3e-53 175.6 In-house 132-289 (290) alignment 
Range on Protein: 2-159
Range on HMM: 132-289/290.0
CCYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 |.||| .|.  ..||. .| |  . .|.||||||........ ..  |.|.|.|||. .| . .| |.|.||  ... | | | ...||||||||.||.
kCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsa

VYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHSTY
|.|.. .....|| |||.||||| || |  ||| |.| .||  |.. .  ||.  .||
vfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-162 2e-52 173.0 In-house 126-287 (287) alignment 
Range on Protein: 1-162
Range on HMM: 126-287/287.0
ECCYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
| ||||| |.. | .||| .. |  .  .|||||||... ......   |.|.|.|||.  | . ||.|.| ||.. .. |.| | ...|||||||| ||
evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

GVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHSTYANF
...|.. .....|| |||.||||| || |  |||.| | .||  |.... .||.  .||..|
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_PTPRD_pd Subfamily PTPRD 3-159 1.1e-41 138.1 In-house 133-287 (564) alignment 
Range on Protein: 3-159
Range on HMM: 133-287/564.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIrSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGV
| .|| |..  ..||. |.   ... . |. |.. . ..|..|.|  | ||. |.||  ||  .....|..|..| . . . . ||.|||||  | |.|.
chkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGt

YCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHSTY
.. ... ||. |.|..||..|. | .|. ..  | | .||. |.|||  .|.  .| 
fividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 3-160 6.2e-41 135.6 In-house 141-297 (298) alignment 
Range on Protein: 3-160
Range on HMM: 141-297/298.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. .|| ...  ..||  |. | ...   .| |||.. . |.. ..  |.|...|.||  || .. ..||.....|   ||. |  ||.|.||. | ||| 
yhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGt

YCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHSTYA
.. ..  ||. |.| ||||||| | .|...||||.| .||. ||||.  .|.  ....
fiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 3-158 7.2e-41 135.3 In-house 133-288 (319) alignment 
Range on Protein: 3-158
Range on HMM: 133-288/319.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. .|| | .....|.. |. .  .  ..|| |||...  ...  . .|..|| |.|| ..| .. ...|... .. . ..|   ||.|||||. | | | 
lkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGt

YCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHST
.. ....||. | |||.|||.. . .|  ..  | . .||. ||||.  ...  .|
fivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
0050432 (Phosphotyrosine protein) phosphatases II 3-161 9.6e-41 135.5 In-house 150-307 (308) alignment 
Range on Protein: 3-161
Range on HMM: 150-307/308.0
CYQYWRES---EIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSR
|.||| ..   .....| ..|..|  . ...|. |.|...  ...  |  | .|. |||| .||  .|. .|. .. | ...   .|||.|||||. |.|
caqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGR

SGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHSTYAN
.|... . ..||| ..|| ||||.. | .|. .||.|.|..||  .|.|. .||||. |..|
tGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkln
0036941 (Phosphotyrosine protein) phosphatases II 3-158 2.8e-39 130.6 In-house 120-282 (297) alignment 
Range on Protein: 3-158
Range on HMM: 120-282/297.0
CYQYWRES--EIVQFGEYFVKCLLSKD--CNGYIERKLHIRSDkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTV
|.||| .   | ...|...|..|  .   ...|. |.|..    ... |  | .|..|.|| .||   |...|. |. | ...... .||||.||||. |
caqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

SRSGVYCSVSVALEQCK---AEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHST
.|||... . ..|.| .    || ||.... |..|. .||||.||.||  .|||. ..|| . |
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0046845 (Phosphotyrosine protein) phosphatases II 2-161 3e-39 130.5 In-house 118-282 (284) alignment 
Range on Protein: 2-161
Range on HMM: 118-282/284.0
CCYQYWRESE-IVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQK-IGGGPVVVHCSDTVSR
 |.||| ...  ...|...|..|  . ...|. |.| ..  . .. |  | .|..|.|| .||  .|. .|. ...| . ...  ||||.|||||. |.|
kcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgR

SGVYCSVSVALEQCKAEG---VVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHSTYAN
.|... . ..||| ..||   .|||... | .|. .||.|.||.||  .|||. .||||. |...
tGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
0051299 (Phosphotyrosine protein) phosphatases II 2-154 8.3e-39 129.2 In-house 133-287 (288) alignment 
Range on Protein: 2-154
Range on HMM: 133-287/288.0
CCYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDK---NDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVS
 |.||| ... ...|...|..|  . ...|. |.|...  .    |. |  | .|..|||| .||   |. .|. . .|.. ..  ||||||||||. |.
kcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvg

RSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLK
|.|... . ..||| ..||.|||... | .|. .||.|.|..||  .|||. .|||
RtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 3-160 1.9e-38 127.1 In-house 93-249 (250) alignment 
Range on Protein: 3-160
Range on HMM: 93-249/250.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. |||   .  ..|.  |. | ..    |. ||| . . |. ...  |.|.. ..||  || .. ..||.....|   ||..| .||.|.||  |.||| 
yhqywPvekaekyGdvtvsllskeefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

YCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHSTYA
.. ..  ||. | | |||||.| | .|. .|.||..|.||...||.|  .|.  . ||
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
0040438 (Phosphotyrosine protein) phosphatases II 3-159 2.5e-38 127.5 In-house 128-282 (317) alignment 
Range on Protein: 3-159
Range on HMM: 128-282/317.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkiG-GGPVVVHCSDTVSRSG
|.||| . | ...|...|..|  . ..|.. |.|..  . .|| |  | .|. |.|| .||   |...|. .. | . ..  . ||||.||||. |.|.|
caqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtG

VYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHSTY
... . ..|||.. || |||... | .|. .||||.|..||  .|.|. .||| . |.
tfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 3-160 2.1e-37 123.9 In-house 131-287 (318) alignment 
Range on Protein: 3-160
Range on HMM: 131-287/318.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSdKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. .|| ...  ..|.  |.   ..... |. |.....  .. ..| .| |...|.||  ||  .. ..|... .| . ||| | ||.|||||  | | ||
vhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGv

YCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHSTYA
.. |.. ||. |||..|||||. | .|. ..  | | |||  ||...  .|.   |..
fiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
0047943 (Phosphotyrosine protein) phosphatases II 3-153 2.1e-37 124.5 In-house 119-272 (273) alignment 
Range on Protein: 3-153
Range on HMM: 119-272/273.0
CYQYWRESE---IVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVS
|.||| ...    ...|...|..|  . ...|. |.| ... ...  |  | .|..|.|| .||   .  .|. |..| . .... ..||||||||. |.
caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvg

RSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
|.|... . ..|.| ..|| |||... | .|. .||.|.|..||  .|||. .||
RtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 2-157 5.4e-37 123.3 In-house 141-293 (297) alignment 
Range on Protein: 2-157
Range on HMM: 141-293/297.0
CCYQYWRESEIvQFGEYFVKCLLSKDCNGYIERKLHIRSdknDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRS
.|.||| |..  ..|...|..|  . ..||. |.|...    .. |  | .||.|.|| .||   ....|.... | .....  .||||.||||. |.|.
kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRt

GVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHS
|...    .|||.. || |||... | .|. .||||.|..||  .|.|. ..|| . 
GtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0043336 (Phosphotyrosine protein) phosphatases II 3-153 3.5e-36 120.5 In-house 130-277 (278) alignment 
Range on Protein: 3-153
Range on HMM: 130-277/278.0
CYQYWReSEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSsWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGV
|.|||  .. ...|...|..|  . ...|. |.|..   ... |   |.... ..|| .||   . ..|. . .|.....   .|||.||||. |.|.|.
caqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGt

YCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
.. . ..||| . || ||.... | .|. .||||.|..||  .|||. .||
fialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 3-149 4e-36 120.0 Pfam-A 84-233 (235) alignment 
Range on Protein: 3-149
Range on HMM: 84-233/235.0
CYQYWR--ESEIVQFGEYFVKCL-LSK-DCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVS
| |||   |.| ...|...|..   .| |...|. |||.....|..| .  | |...||||  || ..|. .|..|..| ... .   ||||||||. |.
caqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvg

RSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAI
|.|........|||..||. |||.|. |..|...||.|..|.||  .|.||
RtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 3-149 4e-36 120.0 In-house 84-233 (235) alignment 
Range on Protein: 3-149
Range on HMM: 84-233/235.0
CYQYWR--ESEIVQFGEYFVKCL-LSK-DCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVS
| |||   |.| ...|...|..   .| |...|. |||.....|..| .  | |...||||  || ..|. .|..|..| ... .   ||||||||. |.
caqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvg

RSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAI
|.|........|||..||. |||.|. |..|...||.|..|.||  .|.||
RtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
DSPc_SM00195 3-153 4.4e-36 119.9 In-house 111-262 (263) alignment 
Range on Protein: 3-153
Range on HMM: 111-262/263.0
CYQYWRES--EIVQFGEYFVKCLLSKDCN-GYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSR
|..|| |.  .  .||.. ||.   . ..  .| |.|... ... . . .| |.|..|||  ||  ... ||...  | ......  ||.|||||. |.|
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
.|........|.....|  ||.|.. |..| ..||.|.||.||. |||||  |.
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 3-153 4.4e-36 119.9 In-house 111-262 (263) alignment 
Range on Protein: 3-153
Range on HMM: 111-262/263.0
CYQYWRES--EIVQFGEYFVKCLLSKDCN-GYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSR
|..|| |.  .  .||.. ||.   . ..  .| |.|... ... . . .| |.|..|||  ||  ... ||...  | ......  ||.|||||. |.|
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
.|........|.....|  ||.|.. |..| ..||.|.||.||. |||||  |.
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0040439 (Phosphotyrosine protein) phosphatases II 3-153 1.2e-35 118.7 In-house 96-246 (249) alignment 
Range on Protein: 3-153
Range on HMM: 96-246/249.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSG
|.||| ... ...|...|..|  . ...|. |.|..     |..|  | ..|.|.|| .||   . ..|. |. | . ....  ||||.||||. |.|.|
caqywplggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

VYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
...    .||| . |. ||.... | .|. .||||....||  .|||. ..|
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0045450 (Phosphotyrosine protein) phosphatases II 2-153 3.1e-35 117.8 In-house 148-304 (307) alignment 
Range on Protein: 2-153
Range on HMM: 148-304/307.0
CCYQYWRES-EIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSR
 |.||| .. | ...|...|..|  . ..||. |.|..   . .. |  | .|. |.|| .||   . ..|. |. | . ...  .||||.||||. |.|
kcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgR

SGVYCSVSVALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
.|...   ..|.| ..||.   ||.... | .|. .||||....||  .|||. ..|
tGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Ptp69D_pd Subfamily Ptp69D 3-155 1.6e-34 114.4 In-house 133-288 (307) alignment 
Range on Protein: 3-155
Range on HMM: 133-288/307.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDS----SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVS
| .|| . ..||.|.  ||.  .. .. ||.|.|..   |..|     |  |||.. |.|.   | . .|..|..|. | . ...   .|.|||||  |.
cakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvg

RSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKL
|||.. .... |.|.|||  ||.|...| .|. ..  |. |.||. .| |.  | . 
rsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
0042113 (Phosphotyrosine protein) phosphatases II 3-153 3e-34 113.9 In-house 94-243 (245) alignment 
Range on Protein: 3-153
Range on HMM: 94-243/245.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSdKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
|.||| ..|....|...|..|  . ...|. |.|..   . |. |  |.... ..|| .||   ....|.... | . ... ..|||.||||. |.|.|.
caqywplgesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

YCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
.. .  .||| ..|. |..... | .|. .||||.|..||  .|||. ..|
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2-155 3.6e-33 109.9 In-house 132-286 (297) alignment 
Range on Protein: 2-155
Range on HMM: 132-286/297.0
CCYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSsWDVVQFQVTNWPTDGVIR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSR
 | .|| .. ...||.  |. |  ....|.|.|.|... .|. .    | |.| ..||.. | |  . ...|..|..| .  ..   ||..|||.  | |
kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakar.rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGr

SGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKL
 ||....   . . | |  ||.|.. | .|...|  | | .||. .|.|.  .|  
tgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_PTPRA_pd Subfamily PTPRA 2-153 7.8e-33 108.7 In-house 142-295 (330) alignment 
Range on Protein: 2-153
Range on HMM: 142-295/330.0
CCYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIR---SDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVS
 |.||| .  .| .|.  |.   .. .. |  ||. ..     ... .|  | ||  | ||  ||  ||. .|...  | . .|. .| |.|||||  | 
kcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvG

RSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
|.| .. ..  ||. |||..||||.. |..|  .|  | |. ||  ||...  | 
rtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPN6_pd Subfamily PTPN6 2-158 8.6e-33 108.6 In-house 139-302 (306) alignment 
Range on Protein: 2-158
Range on HMM: 139-302/306.0
CCYQYWRESEI-VQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTV
 |..|| ..|   ..|.. |... .|. . || |.|..   |..... .|.|.. ..||  || ..| .||. ..|| ..|...     ||.|||||. .
kCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGi

SRSGVYCSVSVALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHST
 | | .  . . |.. . .|.   .|. .. ||||. . | | | .||  .|.||..|.. ...
GRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 3-158 1.2e-32 108.0 In-house 129-282 (315) alignment 
Range on Protein: 3-158
Range on HMM: 129-282/315.0
CYQYWRE--SEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKndsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRS
| ||| .  .. |.||.. |. |  . . . . ||| .|  .   .|  | ||| |.||  || ..  ..|..| .|    ..    ...||||  | |.
crqywPdrkadsvefGsikvellsleadtdgvarklvtrkse...esrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrt

GVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHST
|| .|.   ..| | . .||||.. | .|. .|  | | ..|. ||.|.  .|. . |
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-158 1.1e-31 104.5 In-house 128-281 (515) alignment 
Range on Protein: 3-158
Range on HMM: 128-281/515.0
CYQYWRE--SEIVQFGEYFVKCLLSKDCNGYIERKLHIRsdKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRS
| .|| .  .. |.||.. |. .  . | | | |||..   |.|  |  | ||. |.||  || .. ...|..| .|   ....   |...|||  | | 
cgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl..kgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrt

GVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLHST
||..|.   . . |   .||||.. . .|. .|  | | .||. ||.|.  .|.   |
Gvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrnt
0037934 (Phosphotyrosine protein) phosphatases II 3-153 1.5e-31 105.3 In-house 90-242 (243) alignment 
Range on Protein: 3-153
Range on HMM: 90-242/243.0
CYQYWReSEIvQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSD
|.|||  .|. ..|...|..| .. ...|. |.|...  . |  .. |.... ..||  ||  .|  .|. .|.|.  ...        .||||.|||| 
caqywp.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

TVSRSGVYCSVSVALEQCkaeGvVDVFQVTKSVRRSKPG-AVTTLDQYSSIYEAISMYL
 |.|.|...   . |...   | ||.... | .|. .|| ||.|..||  .|||. ..|
GvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 3-155 2.2e-31 104.7 In-house 106-274 (278) alignment 
Range on Protein: 3-155
Range on HMM: 106-274/278.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSD---KNDSSSWDVVQFQVTNWPTDGVIREP--RTVLQVIDDVIHRQQK------------IG
|.||| |.. ...|...|..|  . .. |. |.|...     ..|  |. | ... ..||  ||  .|  . .|.... . .....             .
caqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

GGPVVVHCSDTVSRSGVYCSVSVALEQCkaEGVVDVFQVTKSVRRSKPG-AVTTLDQYSSIYEAISMYLKL
||||.||||  |.|.|... .   ||..  ||.||.... | .|. .|| ||..|.||  .||.. ..|. 
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPRK_pd Subfamily PTPRK 3-149 5.7e-31 102.5 In-house 128-273 (314) alignment 
Range on Protein: 3-149
Range on HMM: 128-273/314.0
CYQYWRESEIVqFGEYFVKCLLSKDCNGYIERKLHIRS-DKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSG
|..|| |   | .|.  |... ..  . .. | . ..   .. .    | ||| ..||. .|  . ...|...  | . |.. . |..|||||    |.|
ClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtG

VYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAI
... ... |.  . |||||||.. |..| .|.  | | .||  ||..|
tfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-149 7.9e-30 98.7 In-house 116-262 (283) alignment 
Range on Protein: 2-149
Range on HMM: 116-262/283.0
CCYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWpTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 | ||| .   ...||. |        | .| ..| .| .    |.  .  .|| .| ..     .   |  .. ||  |..   ||.||||| .. |..
kCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrta

VYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAI
|....|..... ..| |||||.| | .|  ...|| |||||  ..|..
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2-153 3.6e-29 96.9 In-house 131-288 (325) alignment 
Range on Protein: 2-153
Range on HMM: 131-288/325.0
CCYQYWRES--EIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-----GGGPVVVHCS
 | .|| .   . ..||   ||    ..   |. |.|...  |.   .  | |||.  |.  || . | |.. ... | . ....     . .|..||||
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

DTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
. | |.||. |.  ||..   |  ||.|.. | .|. .|  | | |||. ||||.  ..
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPRG_pd Subfamily PTPRG 3-153 7.9e-28 92.0 In-house 133-287 (563) alignment 
Range on Protein: 3-153
Range on HMM: 133-287/563.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRS---DKN-D-SSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTV
| .|| . | ...|.  |.   ..    | .|.| |.    .|. .  .   | |.. |.||  ||   .  ||. .     . .|   ||.|||||  |
cdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGv

SRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| .||  ...|.   .
grtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai
subfamily_CG7180_pd Subfamily CG7180 3-153 6e-27 89.1 In-house 126-290 (296) alignment 
Range on Protein: 3-153
Range on HMM: 126-290/296.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSD------K---NDSSSWDVVQFQVTNWPT-DGVIREPRTVLQVIDDVIHRQQKI----GGGP
. .|| .    |.|| ||. . .|       |....         .    .     | .||.| |.  | |     ......  |   ..|.      ||
ypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegP

VVVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
|||..|| .||||||... ..||. . |. ||||.  | .|||.|. | . ..|  ||. .. ..
vvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_PTPN12_pd Subfamily PTPN12 3-154 9.1e-27 88.7 In-house 125-278 (290) alignment 
Range on Protein: 3-154
Range on HMM: 125-278/290.0
CYQYWRES--EIVQFGEYFVKCLLSKDCN-GYIERKLHIRSDkndSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSR
| .|| |.  | ..|||. |..   | .. ... | |... .   . |  | ||. |.||  || . . ..|..|..| ..|.     |.|||||  | |
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGr

SGVYCSVSVALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLK
 |. ...  . |. ||| .   .|||..  ..|. .. .| | .||. .|.|.  ...
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 3-154 1e-26 88.7 In-house 126-277 (281) alignment 
Range on Protein: 3-154
Range on HMM: 126-277/281.0
CYQYWRESE-IVQFGEYFVKCLLSKDCNGYIERKLHIrsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
|..|| . .  ...|.. || . ... . |||||...  ..... . .|.|.. |.||  ||  ... .|.  ..| . ..|    |.|.|||  | |.|
ChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtG

VYCSVSVALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLK
.| ..  ......||   .|| .| ...|...   | |. ||. .| |.  .|.
tyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-150 1.4e-26 88.2 In-house 132-276 (288) alignment 
Range on Protein: 3-150
Range on HMM: 132-276/288.0
CYQYWRESEI-VQFGEYFVKCLLSKDCNGYIERKLHIRsdkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSG
| .|| ...  ...|.  |. . ||. . ...||| .     . .  .. |.| . || .|| .  . .|.... |   .|.   ||..||||. | |.|
CeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtg

VYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAIS
.. ..  .... ..| ..||. . . .|....  | || ||  |||.. 
tFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 3-155 2.1e-26 87.7 In-house 115-270 (274) alignment 
Range on Protein: 3-155
Range on HMM: 115-270/274.0
CYQYWRESEIV----QFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSswdVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDT
| .|. ..| .    ..|.  .|    ...|.|  ||| ... ..  |   |. .  |.||   . ....|.|.....| . ...     .|||||||  
CavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

VSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKL
. | |.. ..|.|. | ..|.||||....  .|  . | | | .||  |..|...||| 
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
PTPc_DSPc_SM00012 50-149 4.7e-26 86.4 In-house 2-103 (105) alignment 
Range on Protein: 50-149
Range on HMM: 2-103/105.0
VVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSVALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
| ....|.||  || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ....|.|...| . ||.||. |..|...||.|.|..||. .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AI
|.
al
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-156 4.8e-26 86.8 In-house 139-295 (319) alignment 
Range on Protein: 2-156
Range on HMM: 139-295/319.0
CCYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRS
 | |||     .. ... ||  . .... |. |....  | .     .. ||    ||  ||   |  ...... | | ..|  .  ..|||||  | |.
kcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

GVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISM-YLKLH
|||  . | |.. | |  |||... . .|. ..  |  | ||  || |.   .|  |
Gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 3-149 5e-26 86.3 In-house 134-275 (315) alignment 
Range on Protein: 3-149
Range on HMM: 134-275/315.0
CYQYWRESEIVqFGEYFVKCLLSKDCNGYIERKLhirSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGV
. .|| . ... .|.. |     .  . |  | |   |   ..   .|||...| ||. || .   .....|  |   ...   |..|||||. | |.| 
aekywpdkkvi.yGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGt

YCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAI
.....  |.| .|| ..||... . ||. . ..| ...||  ||.|.
fitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-156 7e-26 86.4 In-house 103-259 (284) alignment 
Range on Protein: 2-156
Range on HMM: 103-259/284.0
CCYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRS
 | |||     .. ... ||  . .... |. |....  | .     .. ||    ||  ||   |  ...... | | ..|  .  ..|||||  | |.
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISM-YLKLH
|||  . | |.. | |  |||... . .|. ..  |  | ||  || |.   .|  |
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_PTPRB_pd Subfamily PTPRB 3-154 9.1e-26 85.6 In-house 136-286 (293) alignment 
Range on Protein: 3-154
Range on HMM: 136-286/293.0
CYQYWRES-EIVQFGEYFVKCLLSKDCNGYIERKLHIRSdknDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRS
| .|| .  | |..|.  |. . ... . .. |.|.|.    .... .| |.. | ||  ||  ...|.|. .  | ... ..   .|.|||||  | |.
CeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRt

GVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLK
|.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .|.
GtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN3_pd Subfamily PTPN3 3-150 4.1e-25 83.2 In-house 126-272 (280) alignment 
Range on Protein: 3-150
Range on HMM: 126-272/280.0
CYQYWRE-SEIVQFGEYFVKCLLSKDCNGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSG
|.||| | .. ...||. |||  ..  . |. |.| .. ||. . .  ..|.| ..||  ||  ..  .|.... | .....    |||||||  . |.|
ChqyWPetedeleygefsvkcekedetksyvlrelvlk.dketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtG

VYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAIS
|.  . .||    |.  | . .. . .|  .   | | .||  . ||| 
vlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 3-155 2.9e-24 80.5 In-house 106-266 (270) alignment 
Range on Protein: 3-155
Range on HMM: 106-266/270.0
CYQYWRESEI----VQFGEYFVKCLLSKDCNGYIERKLHIRsdkNDSSSWDVVQFQVTNWPTDGVIREPR------TVLQVIDDV-IHRQQKIGGGPVVV
| .|| ..      ...|.  |  | ..  .||| ..|...   .....  .| |. ..|| .|| ||.        .|... .|  .....  ..|..|
CerYWpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

HCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKL
|||. | |.|.   .  |..  . .. ||| .. . .|. ..  | . .||  .|.|...| . 
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPN23_pd Subfamily PTPN23 3-152 2e-23 77.6 In-house 125-279 (288) alignment 
Range on Protein: 3-152
Range on HMM: 125-279/288.0
CYQYW--RESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIH---RQQKIGGGPVVVHCSDTV
. .||  .. | |.||.. | .   .. . ..||.|...  ..|    .|.  |.|.||  ||   | |.||..| | .    .|.    |.|||||  |
vdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGv

SRSGVYCSVSVALEQ-CKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMY
 |.||.. |  |...  | .|..|. || . .|. .   | . .|.   |||.  .
gRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN9_pd Subfamily PTPN9 3-153 1.1e-22 75.5 In-house 127-290 (297) alignment 
Range on Protein: 3-153
Range on HMM: 127-290/297.0
CYQYWR--ESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQ------------KIGGGP
| |||   | .  .||.. |. .  .  . | .|.|.|.  |..  |  |. ||.. ||  || ..  ..|.|.. | ..|             .. | |
cgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktee.srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPP

VVVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
.|||||  . |.| .... ..|.. . .|.|||... | .|  .  .. | .||   | |.  | 
ivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN13_pd Subfamily PTPN13 3-154 2.9e-22 74.3 In-house 119-270 (273) alignment 
Range on Protein: 3-154
Range on HMM: 119-270/273.0
CYQYWRESE---IVQFGEYFVKCLLSKDCNGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSR
| .|| ||.   ..  . . |. |  .. .|.  |.|... |.. . | .|.... ..||  || ...  .||..  | . |.    ||.|||||  . |
chrywPesknkklkvsnrlevellkvqkldgfvvralavk.dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGr

SGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLK
||.. .. |.|.  . .  .|| .. ...|. . | | | |||  .|.||   ||
sGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
0051429 (Phosphotyrosine protein) phosphatases II 3-154 3.4e-22 74.8 In-house 63-226 (272) alignment 
Range on Protein: 3-154
Range on HMM: 63-226/272.0
CYQYWR------------ESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPrtVLQVIDDVIHrqqkigGGPVV
|..||             . . . .| ..|..|  . .. || |.| ..   . . .  | ... |.||..|| .|.  .|.... . .      ||||.
cdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvl

VHCSDTVSRSGVYCSVSVALEQCKAEGVVD--------VFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLK
||||  ..|.|... .   |..  .| .||        .... . .|.  |||| | .||  .|||.  .|.
vHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellr
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2-149 3.4e-21 70.6 In-house 86-235 (237) alignment 
Range on Protein: 2-149
Range on HMM: 86-235/237.0
CCYQYWRESEI-VQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSR
 |..|| ...    .| . |     ..   |  | | .    .      . |.| | ||  || ..  ..|.   ..|.| ...   || ..|||  | |
kchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgr

SGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAI
.|..  .   | |.| . |||...  .|.   .|  . | |||  |...|
tgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0036282 (Phosphotyrosine protein) phosphatases II 2-147 7.5e-20 66.8 In-house 53-164 (174) alignment 
Range on Protein: 2-147
Range on HMM: 53-164/174.0
CCYQYWREseivqfgeyfvkcllskdcngyierklhirsdKNDSSSWDVVQFQVTNWPTDGVIREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 |..|| |                                . .. .  ..|.. ..|| .||   .  .|.... | . ... .||||.||||  |.|.|
kcinywpe................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtG

VYCSVSVALEQCKaEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
. .     | . . |..||.... ...|. .||.|.| .||  .|.
tlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 3-153 4.1e-19 63.4 In-house 128-279 (439) alignment 
Range on Protein: 3-153
Range on HMM: 128-279/439.0
CYQYWRESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDS-SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 |.||  .. | .|.  |..    .   |. | ...  ... .     |.||. . ||   |  .   ||. .  .   ..|   ||||||||  | |.|
sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtG

VYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
   .. .|||| |.|  ||.  . | .|. .   | .| ||  ||.|.   .
tiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 45-152 7.4e-19 62.4 In-house 86-193 (440) alignment 
Range on Protein: 45-152
Range on HMM: 86-193/440.0
SSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSS
  |  . |..   ||  || .    ||..|.|| . |.| | ||..||||  ..|.||  .|   | ..|    .|.| . .|.| ..|  | | .||. 
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IYEAISMY
..||.   
vheavleg
subfamily_PTPN1_pd Subfamily PTPN1 3-149 1.8e-18 61.3 In-house 113-267 (290) alignment 
Range on Protein: 3-149
Range on HMM: 113-267/290.0
CYQYWRES---EIVQFG--EYFVKCLLSKDCNGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSDT
|.||| .    . ...   .. || .  .. . |. |.|..  ...   . ....|  | ||  || . | . |. . .| .    .   ||.|.|||  
caqywPqgeeekellledtklkvkliseerksyytvrllele.nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VSRSGVYCSVSVALEQCKAEG---VVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAI
. ||| .| |   | . ....    ||. .|   .|. . | . | ||    | ||
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_PTPN14_pd Subfamily PTPN14 2-154 1.9e-18 61.5 In-house 134-297 (300) alignment 
Range on Protein: 2-154
Range on HMM: 134-297/300.0
CCYQYWRES----EIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDV---IH-RQQKI----GGGPV
 ...|. ..    . |.||.. |   .|.| . .| ..|...     .   .|. .| |.|| .|| ..... |. ...|    .  ....       ||
ksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlps.keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

VVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLK
.||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||  .|...  |||
lvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 40-153 3.4e-18 60.2 In-house 125-236 (392) alignment 
Range on Protein: 40-153
Range on HMM: 125-236/392.0
SDKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
 || |.    | ||..|.|| ..| .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | 
gdkgdd.artvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtk

DQYSSIYEAISMYL
.||. || |.   |
eqyafiygavledl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3-149 4.3e-18 60.3 In-house 93-236 (239) alignment 
Range on Protein: 3-149
Range on HMM: 93-236/239.0
CYQYWRESEiVQFGEYFVKCLLSKDCNGYIERKLhIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGV
|.||| .|   .. .  |    ..    || | . . |.  ..    | |...| ||  || .   .|| .    | ..   |  | |.|||  | |.| 
chqywpdst.skycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAI
.  .   | |.| .  ||.|.  |..|  .|  | | .||  |. |.
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
0041856 (Phosphotyrosine protein) phosphatases II 2-155 4.4e-18 60.9 In-house 66-173 (182) alignment 
Range on Protein: 2-155
Range on HMM: 66-173/182.0
CCYQYWReseivqfgeyfvkcllskdcngyierklhirsdknDSSSWDVVQFQVTNWPTDGVIRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSG
....||                                    .     ..|.. ..|| .||   ....|. |..|..      ||||.||||  |.|.|
teelywp...................................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtg

VYCSVSVALEQckaeGvVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKL
...   . ...    | |..... | ||. .||.|.|..||  .. |. ..|.|
tlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3-149 4.4e-18 60.3 In-house 94-237 (239) alignment 
Range on Protein: 3-149
Range on HMM: 94-237/239.0
CYQYWRESEiVQFGEYFVKCLLSKDCNGYIERKLhIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGV
|.||| .|   .. .  |    ..    || | . . |.  ..    | |...| ||  || .   .|| .    | ..   |  | |.|||  | |.| 
chqywpdst.skycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAI
.  .   | |.| .  ||.|.  |..|  .|  | | .||  |. |.
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 3-156 1.6e-17 58.2 In-house 122-280 (287) alignment 
Range on Protein: 3-156
Range on HMM: 122-280/287.0
CYQYWRESEI-VQFGEYFVKCLlSKDC--NGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSD
||.|| | |  .. | | |  | ..|     |  | | .  | .   .  | |... .|| ...        | ||.| . .  ...  . ||.|||.. 
cykywPerevPmrvGGysvvll.dydikePeygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv

TVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLH
 . |||.. .. | ... .  | ||| .|   .|  . . | .  |.  .|||.  | |  
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 18-152 3.4e-17 57.3 In-house 128-258 (267) alignment 
Range on Protein: 18-152
Range on HMM: 128-258/267.0
YFVKCLLSKDCNGYIERKLHIRSdKNDsSSWDVVQFQVTNWPTDGVirePRTVLQVIDD-VIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSVALEQCKAE
  |.  | |. | |    | ..  ||. |. .|. .   .|  .      .  |. .   . . | . |. |.||.||| | ||| .  .   ||. | |
ltvehslekeendyqiitlelkf.kne.sahnvtlyyykkwnintn...nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakte

GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMY
||.|.|.  . .|  ..| | |...|  |.| .. |
gvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 3-152 6.4e-17 56.1 In-house 136-282 (290) alignment 
Range on Protein: 3-152
Range on HMM: 136-282/290.0
CYQYWR--ESEIVQFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSRS
| ||.   | |.. |||. | | ...| .  | .|.    ||..  .  .  ...  ||   |     ..|...  .  |.     ||||||||  . |.
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrt

GVYCSVSVALeQCKAEG-VVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMY
| . .. |.| |.  .|  .|. .. ...|.|. ..|    ||  . |..  .
Gtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
0043147 (Phosphotyrosine protein) phosphatases II 47-147 1.1e-16 56.5 In-house 62-155 (172) alignment 
Range on Protein: 47-147
Range on HMM: 62-155/172.0
SWDVVQFQVTNWPTDGVIrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSVALeqckaeG-VvDVFQVTKSVRRSKPGAVTTLDQYSSI
.  ..|.. ..||  ||   .. .|.... . .....  ||||.||||  |.|.|. .     |        . ..... . ||. .||||.. .||  .
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrfl

YE
|.
yy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 3-154 3.3e-16 54.3 In-house 113-260 (290) alignment 
Range on Protein: 3-154
Range on HMM: 113-260/290.0
CYQYWRES--EIVQFGEYFVKCLLSKDCNGYIERKLHIRSDknDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRS
| .| .||  |...|.   |||      .. ..|.| .. |  |   . |   .. .| .  | ....|.|..|. |  ..      ||.||| | .|||
CakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd..deeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrs

GVYCSVSVALEQCK-AEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLK
 .  .. ..       .| | . .| |..|. .  |.|.  ... .  .| ....
AalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllai
subfamily_PTPRN_pd Subfamily PTPRN 3-150 3.4e-16 53.8 In-house 142-289 (297) alignment 
Range on Protein: 3-150
Range on HMM: 142-289/297.0
CYQYWRESEIVQFGEYFVKcLLSK--DCNGYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRS
|..|| .     .. | |. |.|.   |. |. | ....  .. | .  | ||    ||  ||  .....|.    |  .  .    |.|||||| . |.
ckrywpdeGsevyhiyevh.lvsehiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrt

GVYCSVSVALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAIS
|||. . . |..  |    .|.    . .|  .|| | | ||.  .. |..
GvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
0046846 (Phosphotyrosine protein) phosphatases II 3-153 9.7e-16 53.5 In-house 65-173 (176) alignment 
Range on Protein: 3-153
Range on HMM: 65-173/176.0
CYQYWRESEIVQFgeyfvkcllskdcngyierklhirsdkndssswdvvQFQVTNWPTDGVIREpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGV
|..|| | | ...                                    |.....||  ||    . .|.... .  ....  ||||.||||  ..|.|.
cpnywpeleklgi....................................qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgt

YCSVSvaleQCKAEGVVDVFQVTKSVRRSKP-GAVTTLDQYSSIYEAISMYL
..        .. |  ..|... . ||. .| |||.| .||  .||.. ..|
lvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
0048076 (Phosphotyrosine protein) phosphatases II 42-152 1.4e-15 52.7 In-house 39-142 (145) alignment 
Range on Protein: 42-152
Range on HMM: 39-142/145.0
KNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsvALEQCKAEGvVDVFQVTKSVRRSKPGAVTTLDQ
  .  .  ..|.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.|...    |.  .. .| |..... . ||.  ||||.. .|
elellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpgq

YSSIYEAISMY
.  .||.. ..
lrflyefelel
0049260 (Phosphotyrosine protein) phosphatases II 12-147 1.2e-14 49.7 In-house 55-144 (152) alignment 
Range on Protein: 12-147
Range on HMM: 55-144/152.0
IvqfgeyfvkcllskdcngyierklhirsdkndssswdvvQFQVTNWPTDGVIREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSVALe
|                                       |.. ..|| .||   .  .|.... . .. ..  ||||.||||  |.|.|...     | 
i.......................................qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml.

qckaeGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
       |..... . ||. .||||.. .|.  .||
.....lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_CG42327_pd Subfamily CG42327 86-154 1.3e-14 48.6 In-house 247-316 (319) alignment 
Range on Protein: 86-154
Range on HMM: 247-316/319.0
GGPVVVHCSDTVSRSGVYCSVSVALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLK
 ||.|||||| | |.|.  .  .|... .     ||. |.  |||| .  || | .||  ||  .|.| |
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
0051082 (Phosphotyrosine protein) phosphatases II 11-148 1.5e-14 49.3 In-house 57-148 (151) alignment 
Range on Protein: 11-148
Range on HMM: 57-148/151.0
EivqfgeyfvkcllskdcngyierklhirsdkndsssWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSVAL
.                                     .|.......||. |.   . .||.... ...     ..|||.||||  ..|.|. . .   |
g....................................ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylml

EQckaegvVDVFQVTKSVRRSKPGAVTTLDQYSSIYEA
..      |..... . .|.. ||.|.. .|.  .. |
lg......vsleealeeyrlkrpgvvqpnqqflfqlfa
0048179 (Phosphotyrosine protein) phosphatases II 35-147 1.7e-14 49.3 In-house 48-139 (144) alignment 
Range on Protein: 35-147
Range on HMM: 48-139/144.0
KlhirsdkndssswdVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCsvsvALEQCKAEGvVDVFQVTKSVRRSKPG
               ..|.. ..||  ||   .  .|.... . . ..   ||||.||||  |.|.|...    |.  .| .| ...... . ||.  ||
e..............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlv....aaylmkklg.lsleealalvrsrrpg

AVTTLDQYSSIYE
||.. .|.  ..|
avpnpgqlrfLle
0044763 (Phosphotyrosine protein) phosphatases II 37-155 7.3e-13 44.0 In-house 75-173 (178) alignment 
Range on Protein: 37-155
Range on HMM: 75-173/178.0
HirsdkndssswdvvqFQVTNWPTDGVIREP-RTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSVALEQckaeGVvDVFQVTKSVRRSKPgA
.               .|. ..|...    . .  .. . . |.. ..  ||||.||||  |.|||. .     ...    |. ..... . ||. .| .
g...............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.i

VTTLDQYSSIYEAISMYLKL
|.. .|.  .||  ...|| 
vpnpgqlrqLyefelrllke
0049772 (Phosphotyrosine protein) phosphatases II 47-155 8.9e-13 44.1 In-house 177-282 (314) alignment 
Range on Protein: 47-155
Range on HMM: 177-282/314.0
SWDVVQFQVTNWPTdGVIREPRTVLQVIdDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSVALEQCkaeGVvDVFQVTKSVRRSKP-----GAVTTLDQ
.  ....  ...|  |    .. ..... ..|..     ||||.|||.. ..|.|... .   . ..   || .. .. . ||.  |     |.. .|.|
erlgikylripvpD.gsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleq

YSSIYEAISMYLKL
|  |.||. .||| 
yefilealleylkf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 55-158 2.1e-11 37.8 In-house 188-290 (302) alignment 
Range on Protein: 55-158
Range on HMM: 188-290/302.0
VTNWPTDGVIREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLK
.|||. . |  .  .. . . .| . ..  .  ..|.     . | |.  .. ||.|. ...  . . .. ||.|  .| || .|.|| |.| |. .|.|
ltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

LHST
 . |
kkvt
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 43-142 4.3e-11 36.8 In-house 183-277 (302) alignment 
Range on Protein: 43-142
Range on HMM: 183-277/302.0
NDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQY
..     |  .. . ||  |  .|. | |...      ...     |.||||  | |.|   ..   .. |. . | |. .. . ||. . ||| . .| 
kkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 45-147 7e-11 36.7 In-house 91-197 (198) alignment 
Range on Protein: 45-147
Range on HMM: 91-197/198.0
SSSWDVVQFQVTNWPTDGVIREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSVALEQ--CKAEGVVDVFQVTKSVRRSKPGAVTTLD
 |. .. ..| | |           |  |.   .| .. ..    ||.|||||    .||. .. . .         |||.|.|.| .|... | ...|.
pstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslq

QYSSIYE
.|  ||.
hynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 45-147 7.1e-11 36.6 In-house 92-198 (199) alignment 
Range on Protein: 45-147
Range on HMM: 92-198/199.0
SSSWDVVQFQVTNWPTDGVIREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSVALEQ--CKAEGVVDVFQVTKSVRRSKPGAVTTLD
 |. .. ..| | |           |  |.   .| .. ..    ||.|||||    .||. .. . .         |||.|.|.| .|... | ...|.
pstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslq

QYSSIYE
.|  ||.
hynfiyq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 47-160 1.2e-10 35.9 In-house 175-286 (307) alignment 
Range on Protein: 47-160
Range on HMM: 175-286/307.0
SWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSVALEQ-CKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSI
|  . ..| .|||  || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  .
srtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylyl

YEAI-SMYLKLH-STYA
.  . . .|.|.  ||.
hrvlleyflelyketye
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 25-156 3e-10 34.6 In-house 145-274 (288) alignment 
Range on Protein: 25-156
Range on HMM: 145-274/288.0
SKDCNGYIERKLHIRSDKNDS---SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSVALEQCKAEGVVDV
 |. .  |.. ...   ..      .  | .  . .|. |||  .  . |.... . .  ||    |.|||.|  | |.|    . .|||. . .  . .
vkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgi

FQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLH
 .. .. | ..  |..|  ||  ..  .  .| |.
rsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 47-156 6.9e-10 33.2 In-house 214-347 (350) alignment 
Range on Protein: 47-156
Range on HMM: 214-347/350.0
SWDVVQFQVTNWPTDGVIREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSVALEQ---------------CKAEgVVD-V
 . | |.|| ||.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....   |..                 |. . | .
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDli

FQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLH
... . .|. .   | .|||.  ||||.  | .|.
siivnelrkqrismvqnldqfifiYeallfyfaLr
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 90-155 8e-10 33.0 In-house 2-67 (69) alignment 
Range on Protein: 90-155
Range on HMM: 2-67/69.0
VVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKL
|||||    |.| . .. | . . |.| .||.|   . .|. .|  |    .|  |..|.   |||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 90-155 1.3e-09 32.2 In-house 1-66 (69) alignment 
Range on Protein: 90-155
Range on HMM: 1-66/69.0
VVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKL
|||||    |.| . .. | . . |.| .||.|   . .|. .|  |   ..|  |..|.   |||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 88-150 3.7e-09 30.9 In-house 230-292 (297) alignment 
Range on Protein: 88-150
Range on HMM: 230-292/297.0
PVVVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAIS
...||||  | ||||     | |.. . . . ||  . . .|  ..  | ||.|.  .|.|. 
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 44-156 7.6e-09 29.3 In-house 214-347 (349) alignment 
Range on Protein: 44-156
Range on HMM: 214-347/349.0
DSSSWDVVQFQVTNWPTDGVIREPRTVLQV-------IDDVIHRQ--QKIGGGPVVVHCSDTVSRSGVYCSVSVALE--QCKAEGV--V--------DVF
 .. . ..|.|| ||.  ... .| ..||        |||   |.  ..    ...||||    |.||.. . . |.  .   .    .         ..
vekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

QVTKSVRRSKPGAVTTLDQYSSIYEAISMYLKLH
 .  ..|. .   |  | |.  ||||.  |..|.
iivnelrkqrismvqnlaqfiaiyealLkyfalk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 52-147 3.8e-08 27.2 In-house 194-284 (310) alignment 
Range on Protein: 52-147
Range on HMM: 194-284/310.0
QFQVTNWPTDGVIREP-RTVLQVIddviHRQqkIGGGPVVVHCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
  .  |||  ||  |   || | .      |  .  ||.|||||  . | .| ... ..... .    ||. .|   ...|.   . |  ||  |  
likwpnwpdrgvpdekchtvpqrl....laq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 46-154 4.1e-08 27.3 In-house 184-288 (305) alignment 
Range on Protein: 46-154
Range on HMM: 184-288/305.0
SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSVALEQCKAEGVV-DVFQVTKSVRRSKPGAVTTLDQYSS
..  | ..   .||  ||     ..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  .. . .|  .  .. | .||  
karkvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylf

IYEAISMYLK
... |  |..
vhqvilnyfr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 55-149 4.2e-08 27.2 In-house 174-265 (281) alignment 
Range on Protein: 55-149
Range on HMM: 174-265/281.0
VTNWPTDGVIREPRTVLQVIddvihRQQKIGGGPVVVHCSDTVSRSGVYCSVSVALEQCKAE-GVVDVFQVTKSVRRS-KPGAVTTLDQYSSIYEAI
  .||   |      .|...     |. .    | |.|||  | |||   .| .||.  ..   . |. |.   .| . .  .| ||.||  |.. .
wkewpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 14-141 6.4e-08 26.7 In-house 145-269 (301) alignment 
Range on Protein: 14-141
Range on HMM: 145-269/301.0
QFGEYFVKCLLSKDC--NGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDdVIHRQQKigggPVVVHCSDTVSRSGVYCSVSVALE
. | . .|   ..    .  ..|.|...   .. ..  |. .| ..|.  || .    . .... .. . .|    |.|||||. . ||  . .  .   
digrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkksek....PivvhcsaGiGrsvafigteylar

QCKAEGVVDVFQVTKSVRRSKPGAVTTLDQ
. .|.  ... .  | .|  .  .| |  |
eveadptieltealkhlrehrwngvqtnsq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 3-152 1.5e-07 25.6 In-house 117-269 (285) alignment 
Range on Protein: 3-152
Range on HMM: 117-269/285.0
CYQYWR--ESEIVQFGEYFVKCLLSKD--CNGYIERKLHIRSDKNDSS-SWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTV
|  |.     |.|.||.| .     |.    | |   | .   .. ||    . . ||  || .    . | ....   | . . |    |..||||  |
calyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagv

SRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMY
 |.  .  .  |  .   .  ...... . .|  .  || .  |.  .|  .  |
grtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_ptpA1_pd Subfamily ptpA1 44-110 3.1e-07 24.5 In-house 182-253 (418) alignment 
Range on Protein: 44-110
Range on HMM: 182-253/418.0
DSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSVAL
.  . |. |.|   ||   .    . . |..  .  ||..|        |..||||  | |.| .|.  . .
egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 49-152 1.2e-06 22.4 In-house 189-288 (305) alignment 
Range on Protein: 49-152
Range on HMM: 189-288/305.0
DVVQFQVTNWPTDGVIREPRTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSVALEQCKA-EGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
 | ..| |.||  ||     | |...  .  |  |.   |.|||||  . |.|   ..   ||.      .  . .. |..|  .  .. .  ||  |. 
svrhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihr

AISMY
 .  |
vmlny
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 65-152 2.3e-06 20.4 In-house 220-308 (346) alignment 
Range on Protein: 65-152
Range on HMM: 220-308/346.0
REPRT--VLQVIDDVIHRQQKIGGGPVVVhCSDTVSRSGVYCSVSVALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMY
. |.|  ....| .    .|    |  ||       |.  .     |..|       ..... |.... .||.| .. ||.|||  .  |
qppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdy
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 50-155 2.7e-06 21.3 In-house 178-278 (312) alignment 
Range on Protein: 50-155
Range on HMM: 178-278/312.0
VVQFQVTNWPTDGVIREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYC---SVSVALEQCKAEGVVDVFQVtksVRRSKPGAVTTLDQYSSIY
. ..| . ||  |.     | |...  | ....|    ||. |||  | |.|  .   |.  || . . . | |.| .   .|. .  .| .. ||    
lnhyqwaswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyal

EAISMYLKL
 ..  .|  
rcvleflys
subfamily_DSP1_pd Subfamily DSP1 70-144 7.7e-06 20.1 In-house 80-154 (163) alignment 
Range on Protein: 70-144
Range on HMM: 80-154/163.0
VLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSV-ALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSS
|.. . . |.. .|  .| | .||   .|||   | . .   .... |   |  .  .|. .   | |  | .| .
vfeeviefidevkkk.nGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyek
subfamily_egg_pd Subfamily egg 80-153 8.1e-06 19.7 In-house 195-270 (307) alignment 
Range on Protein: 80-153
Range on HMM: 195-270/307.0
RQQKIGGGPVVVHCSDTVSRSGVYCSVSVALEQCKAEGVV--DVFQVTKSVRRSKPGAVTTLDQYSSIYEAISMYL
|. .    ||||.. . ||....  .. .|| .     ..   | .  . .|. .. .| .  .|  .|  . ...
rklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff