Gene PTPRD-63 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP121_AA protein Get Run
AqueP121_AA_1-155 phosphatase_domain Get Run
AqueP121_AA_178-207 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2-155 7.5e-77 253.0 In-house 126-295 (301) alignment
Range on Protein: 2-155
Range on HMM: 126-295/301.0
CCYQYWRESDTISFGEYFVKCLLSKDC-------------------NGYIERKLHIRSDKndsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQ
.|.|||..|.. |  .......|....                   |||||||....|||   |||||.|.|||.||.|||.||||||||||||||||||
kceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqq

KIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIVL
||||||||||||||||||||||||||.|||||||||||||||||.|||||||||||| .   .. .. |.. |
kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-139 9.8e-51 167.7 In-house 129-269 (305) alignment
Range on Protein: 1-139
Range on HMM: 129-269/305.0
ECCYQYWRESDTI--SFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVS
..|.||| || |    |||. |.   .|  ..||||||.|  ...|. |  |.|.|.|.|| .|| ... ..|..|..| ..|.|  | |..||||..|.
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
|.||...|.||||..|.|.|||||.|.| .|......|.||
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-152 1.2e-49 163.8 In-house 132-282 (290) alignment
Range on Protein: 2-152
Range on HMM: 132-282/290.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 |.||| .||| ..||. .| |  . .|.||||||........ ..  |.|.|.|||. .| . .| |.|.||  ... | | | ...||||||||.||.
kCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsa

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMM
|.|.. .....|| |||.||||| || |  ||| |.| ....... ...  
vfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-152 1.7e-45 150.2 In-house 126-277 (287) alignment
Range on Protein: 1-152
Range on HMM: 126-277/287.0
ECCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
| ||||| |......||| .. |  .  .|||||||... ......   |.|.|.|||.  | . ||.|.| ||.. .. |.| | ...|||||||| ||
evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMM
...|.. .....|| |||.||||| || |  |||.| |    | .. .....
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley

subfamily_PTPRD_pd Subfamily PTPRD 3-138 6.8e-34 112.4 In-house 133-266 (564) alignment
Range on Protein: 3-138
Range on HMM: 133-266/564.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIrSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGV
| .|| |..| ..||. |.   ... . |. |.. . ..|..|.|  | ||. |.||  ||  .....|..|..| . . . . ||.|||||  | |.|.
chkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.. ... ||. |.|..||..|. | .|. ..  | |
fividamlerikeektvDiyqyvkalrkqRnamVqt

0050432 (Phosphotyrosine protein) phosphatases II 3-154 2.4e-33 111.2 In-house 150-300 (308) alignment
Range on Protein: 3-154
Range on HMM: 150-300/308.0
CYQYWRES---DTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSR
|.||| ..   ... .| ..|..|  . ...|. |.|...  ...  |  | .|. |||| .||  .|. .|. .. | ...   .|||.|||||. |.|
caqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIV
.|... . ..||| ..|| ||||.. | .|. .||.|.|.   . ......... 
tGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0046845 (Phosphotyrosine protein) phosphatases II 2-155 3.3e-32 107.4 In-house 118-276 (284) alignment
Range on Protein: 2-155
Range on HMM: 118-276/284.0
CCYQYWRESD-TISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQK-IGGGPVVVHCSDTVSR
 |.||| ... .. .|...|..|  . ...|. |.| ..  . .. |  | .|..|.|| .||  .|. .|. ...| . ...  ||||.|||||. |.|
kcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgR

SGVYCSVSIALEQCKAEG---VVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIVL
.|... . ..||| ..||   .|||... | .|. .||.|.||  ..   ....... |
tGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 3-143 3.5e-32 106.8 In-house 141-280 (298) alignment
Range on Protein: 3-143
Range on HMM: 141-280/298.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. .|| .. .  .||  |. | ...   .| |||.. . |.. ..  |.|...|.||  || .. ..||.....|   ||. |  ||.|.||. | ||| 
yhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIK
.. ..  ||. |.| ||||||| | .|...||||.|    .
fiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYv

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 3-154 3.6e-32 106.7 In-house 133-284 (319) alignment
Range on Protein: 3-154
Range on HMM: 133-284/319.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. .|| | .  ..|.. |. .  .  ..|| |||...  ...  . .|..|| |.|| ..| .. ...|... .. . ..|   ||.|||||. | | | 
lkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIV
.. ....||. | |||.|||.. . .|  ..  | .    |..   .. .. 
fivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

0036941 (Phosphotyrosine protein) phosphatases II 3-156 3.8e-32 107.2 In-house 120-280 (297) alignment
Range on Protein: 3-156
Range on HMM: 120-280/297.0
CYQYWRES--DTISFGEYFVKCLLSKD--CNGYIERKLHIRSDkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTV
|.||| .   ... .|...|..|  .   ...|. |.|..    ... |  | .|..|.|| .||   |...|. |. | ...... .||||.||||. |
caqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

SRSGVYCSVSIALEQCK---AEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIVLF
.|||... . ..|.| .    || ||.... |..|. .||||.||   . . ..... .  .
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

0051299 (Phosphotyrosine protein) phosphatases II 2-150 4.7e-32 107.0 In-house 133-283 (288) alignment
Range on Protein: 2-150
Range on HMM: 133-283/288.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDK---NDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVS
 |.||| ..... .|...|..|  . ...|. |.|...  .    |. |  | .|..|||| .||   |. .|. . .|.. ..  ||||||||||. |.
kcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
|.|... . ..||| ..||.|||... | .|. .||.|.|.  ..   ....
RtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall

0040438 (Phosphotyrosine protein) phosphatases II 3-157 3.8e-31 104.0 In-house 128-278 (317) alignment
Range on Protein: 3-157
Range on HMM: 128-278/317.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkiG-GGPVVVHCSDTVSRSG
|.||| . .|. .|...|..|  . ..|.. |.|..  . .|| |  | .|. |.|| .||   |...|. .. | . ..  . ||||.||||. |.|.|
caqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMIvlFR
... . ..|||.. || |||... | .|. .||||.|.  .. .........   |
tfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl..kr

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 3-138 5.7e-31 102.7 In-house 131-265 (318) alignment
Range on Protein: 3-138
Range on HMM: 131-265/318.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSdKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. .|| .....|.|.  |.   ..... |. |.....  .. ..| .| |...|.||  ||  .. ..|... .| . ||| | ||.|||||  | | ||
vhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGv

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.. |.| ||. |||..|||||. | .|. ..  | |
fiavdillerikaealvDvfqtvkqlreqrnlmvqt

0047943 (Phosphotyrosine protein) phosphatases II 3-151 5.7e-31 103.4 In-house 119-270 (273) alignment
Range on Protein: 3-151
Range on HMM: 119-270/273.0
CYQYWRESD---TISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVS
|.||| ..    .. .|...|..|  . ...|. |.| ... ...  |  | .|..|.|| .||   .  .|. |..| . .... ..||||||||. |.
caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIM
|.|... . ..|.| ..|| |||... | .|. .||.|.|.  .. .......
RtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 3-150 6.4e-31 102.4 In-house 93-239 (250) alignment
Range on Protein: 3-150
Range on HMM: 93-239/250.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. |||    .  .|.  |. | ..    |. ||| . . |. ...  |.|.. ..||  || .. ..||.....|   ||..| .||.|.||  |.||| 
yhqywPvekaekyGdvtvsllskeefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
.. ..  ||. | | |||||.| | .|. .|.||..|     . ....
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiil

Y_phosphatase Protein-tyrosine phosphatase 3-147 3.8e-30 100.4 Pfam-A 84-231 (235) alignment
Range on Protein: 3-147
Range on HMM: 84-231/235.0
CYQYWR--ESDTISFGEYFVKCL-LSK-DCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVS
| |||   |... ..|...|..   .| |...|. |||.....|..| .  | |...||||  || ..|. .|..|..| ... .   ||||||||. |.
caqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMM
|.|......|.|||..||. |||.|. |..|...||.|..|   . ...
RtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk

Y_phosphatase Protein-tyrosine phosphatase 3-147 3.8e-30 100.4 In-house 84-231 (235) alignment
Range on Protein: 3-147
Range on HMM: 84-231/235.0
CYQYWR--ESDTISFGEYFVKCL-LSK-DCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVS
| |||   |... ..|...|..   .| |...|. |||.....|..| .  | |...||||  || ..|. .|..|..| ... .   ||||||||. |.
caqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMM
|.|......|.|||..||. |||.|. |..|...||.|..|   . ...
RtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk

0039614 (Phosphotyrosine protein) phosphatases II 2-152 4.6e-30 100.5 In-house 141-288 (297) alignment
Range on Protein: 2-152
Range on HMM: 141-288/297.0
CCYQYWRESDTiSFGEYFVKCLLSKDCNGYIERKLHIRSdknDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRS
.|.||| |. .  .|...|..|  . ..||. |.|...    .. |  | .||.|.|| .||   ....|.... | .....  .||||.||||. |.|.
kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMM
|...   ..|||.. || |||... | .|. .||||.|.  ..  .......
GtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel

0043336 (Phosphotyrosine protein) phosphatases II 3-147 9.4e-30 99.4 In-house 130-271 (278) alignment
Range on Protein: 3-147
Range on HMM: 130-271/278.0
CYQYWReSDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSsWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGV
|.|||  .... .|...|..|  . ...|. |.|..   ... |   |.... ..|| .||   . ..|. . .|.....   .|||.||||. |.|.|.
caqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMM
.. . ..||| . || ||.... | .|. .||||.|.  ..   .
fialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye

0040439 (Phosphotyrosine protein) phosphatases II 3-149 1.7e-29 98.6 In-house 96-242 (249) alignment
Range on Protein: 3-149
Range on HMM: 96-242/249.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSG
|.||| ..... .|...|..|  . ...|. |.|..     |..|  | ..|.|.|| .||   . ..|. |. | . ....  ||||.||||. |.|.|
caqywplggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
...   ..||| . |. ||.... | .|. .||||...  ..  ....
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal

DSPc_SM00195 3-150 3.6e-29 97.3 In-house 111-259 (263) alignment
Range on Protein: 3-150
Range on HMM: 111-259/263.0
CYQYWRES--DTISFGEYFVKCLLSKDCN-GYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSR
|..|| |.  ..  ||.. ||.   . ..  .| |.|... ... . . .| |.|..|||  ||  ... ||...  | ......  ||.|||||. |.|
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
.|......|.|.....|  ||.|.. |..| ..||.|.||   ........
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail

PTPc_SM00194 3-150 3.6e-29 97.3 In-house 111-259 (263) alignment
Range on Protein: 3-150
Range on HMM: 111-259/263.0
CYQYWRES--DTISFGEYFVKCLLSKDCN-GYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSR
|..|| |.  ..  ||.. ||.   . ..  .| |.|... ... . . .| |.|..|||  ||  ... ||...  | ......  ||.|||||. |.|
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
.|......|.|.....|  ||.|.. |..| ..||.|.||   ........
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail

0045450 (Phosphotyrosine protein) phosphatases II 2-150 5.8e-29 97.2 In-house 148-301 (307) alignment
Range on Protein: 2-150
Range on HMM: 148-301/307.0
CCYQYWRES-DTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSR
 |.||| .. ... .|...|..|  . ..||. |.|..   . .. |  | .|. |.|| .||   . ..|. |. | . ...  .||||.||||. |.|
kcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgR

SGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
.|...   ..|.| ..||.   ||.... | .|. .||||...  ..  .....
tGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

0042113 (Phosphotyrosine protein) phosphatases II 3-149 3.2e-28 94.2 In-house 94-239 (245) alignment
Range on Protein: 3-149
Range on HMM: 94-239/245.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSdKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
|.||| ..... .|...|..|  . ...|. |.|..   . |. |  |.... ..|| .||   ....|.... | . ... ..|||.||||. |.|.|.
caqywplgesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
.. . ..||| ..|. |..... | .|. .||||.|.  .. .....
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal

subfamily_Ptp69D_pd Subfamily Ptp69D 3-139 2e-27 91.1 In-house 133-272 (307) alignment
Range on Protein: 3-139
Range on HMM: 133-272/307.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDS----SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVS
| .|| . |.. .|.  ||.  .. .. ||.|.|..   |..|     |  |||.. |.|.   | . .|..|..|. | . ...   .|.|||||  |.
cakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
|||.. .... |.|.|||  ||.|...| .|. ..  |. |
rsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsl

0037934 (Phosphotyrosine protein) phosphatases II 3-151 2.4e-26 88.2 In-house 90-240 (243) alignment
Range on Protein: 3-151
Range on HMM: 90-240/243.0
CYQYWResDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSD
|.|||   ... .|...|..| .. ...|. |.|...  . |  .. |.... ..||  ||  .|  .|. .|.|.  ...        .||||.|||| 
caqywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

TVSRSGVYCSVSIALEQCkaeGvVDVFQVTKSVRRSKPG-AVTTLVCIKIMMMMMIM
 |.|.|...   . |...   | ||.... | .|. .|| ||.|.  ..  ......
GvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2-138 2.9e-26 87.3 In-house 132-269 (297) alignment
Range on Protein: 2-138
Range on HMM: 132-269/297.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSsWDVVQFQVTNWPTDGVIR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSR
 | .|| .. . .||.  |. |  ....|.|.|.|... .|. .    | |.| ..||.. | |  . ...|..|..| .  ..   ||..|||.  | |
kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakar.rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
 ||....   . . | |  ||.|.. | .|...|  | |
tgvlltidsvvaeakrekevdifglvkklrqerpylvqt

subfamily_PTPRA_pd Subfamily PTPRA 2-142 3.5e-26 86.9 In-house 142-284 (330) alignment
Range on Protein: 2-142
Range on HMM: 142-284/330.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIR---SDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVS
 |.||| .  ....|.  |.   .. .. |  ||. ..     ... .|  | ||  | ||  ||  ||. .|...  | . .|. .| |.|||||  | 
kcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvG

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCI
|.| .. ..  ||. |||..||||.. |..|  .|  | |.   
rtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqy

0045098 (Phosphotyrosine protein) phosphatases II 3-151 3.7e-26 87.6 In-house 106-270 (278) alignment
Range on Protein: 3-151
Range on HMM: 106-270/278.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSD---KNDSSSWDVVQFQVTNWPTDGVIREP--RTVLQVIDDVIHRQQK------------IG
|.||| |.... .|...|..|  . .. |. |.|...     ..|  |. | ... ..||  ||  .|  . .|.... . .....             .
caqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

GGPVVVHCSDTVSRSGVYCSVSIALEQCkaEGVVDVFQVTKSVRRSKPG-AVTTLVCIKIMMMMMIM
||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..|  .. .......
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle

subfamily_PTPN6_pd Subfamily PTPN6 2-149 1.1e-25 85.3 In-house 139-293 (306) alignment
Range on Protein: 2-149
Range on HMM: 139-293/306.0
CCYQYWRES-DTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTV
 |..|| .. .. ..|.. |... .|. . || |.|..   |..... .|.|.. ..||  || ..| .||. ..|| ..|...     ||.|||||. .
kCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGi

SRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
 | | .  . | |.. . .|.   .|. .. ||||. . | | |  . |.. ...
GRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai

subfamily_PTPRK_pd Subfamily PTPRK 3-139 3.3e-25 83.5 In-house 128-263 (314) alignment
Range on Protein: 3-139
Range on HMM: 128-263/314.0
CYQYWRESDTIsFGEYFVKCLLSKDCNGYIERKLHIRS-DKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSG
|..|| |  .. .|.  |... ..  . .. | . ..   .. .    | ||| ..||. .|  . ...|...  | . |.. . |..|||||    |.|
ClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
... ..| |.  . |||||||.. |..| .|.  | | 
tfiaidivldmieregvvdvfnavktlrsrkvnmvete

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-144 5.4e-25 82.8 In-house 116-257 (283) alignment
Range on Protein: 2-144
Range on HMM: 116-257/283.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWpTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 | ||| .  .. .||. |        | .| ..| .| .    |.  .  .|| .| ..     .   |  .. ||  |..   ||.||||| .. |..
kCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrta

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKI
|....| .... ..| |||||.| | .|  ...|| ||   |.
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqykl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 3-138 1.3e-24 81.7 In-house 129-262 (315) alignment
Range on Protein: 3-138
Range on HMM: 129-262/315.0
CYQYWRE--SDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKndsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRS
| ||| .  .|.. ||.. |. |  . . . . ||| .|  .   .|  | ||| |.||  || ..  ..|..| .|    ..    ...||||  | |.
crqywPdrkadsvefGsikvellsleadtdgvarklvtrkse...esrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
|| .|.   ..| | . .||||.. | .|. .|  | |
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-138 5.1e-24 79.2 In-house 128-261 (515) alignment
Range on Protein: 3-138
Range on HMM: 128-261/515.0
CYQYWRE--SDTISFGEYFVKCLLSKDCNGYIERKLHIRsdKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRS
| .|| .  .|.. ||.. |. .  . | | | |||..   |.|  |  | ||. |.||  || .. ...|..| .|   ....   |...|||  | | 
cgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl..kgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
||..|.   . . |   .||||.. . .|. .|  | |
Gvvisidsvvahakttrmvdvfnfvtnirqkrpylvqt

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-152 7.2e-23 76.4 In-house 139-290 (319) alignment
Range on Protein: 2-152
Range on HMM: 139-290/319.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRS
 | |||     |  ... ||  . .... |. |....  | .     .. ||    ||  ||   |  ...... | | ..|  .  ..|||||  | |.
kcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMM
|||  . . |.. | |  |||... . .|. ..  |  ||  |.. . ..  
Gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-158 7.8e-23 76.4 In-house 103-259 (284) alignment
Range on Protein: 2-158
Range on HMM: 103-259/284.0
CCYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRS
 | |||     |  ... ||  . .... |. |....  | .     .. ||    ||  ||   |  ...... | | ..|  .  ..|||||  | |.
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMiVLFRI
|||  . . |.. | |  |||... . .|. ..  |  ||  |.. . ..    ||  
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee.hlfgh

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 3-149 1.5e-22 75.0 In-house 126-272 (281) alignment
Range on Protein: 3-149
Range on HMM: 126-272/281.0
CYQYWRESD-TISFGEYFVKCLLSKDCNGYIERKLHIrsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
|..|| . . ....|.. || . ... . |||||...  ..... . .|.|.. |.||  ||  ... .|.  ..| . ..|    |.|.|||  | |.|
ChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtG

VYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
.| ..  ......||   .|| .| ...|...   | |.|. . .  ..
tyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav

subfamily_PTPRG_pd Subfamily PTPRG 3-138 7e-22 72.3 In-house 133-272 (563) alignment
Range on Protein: 3-138
Range on HMM: 133-272/563.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRS---DKN-D-SSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTV
| .|| . ... .|.  |.   ..    | .|.| |.    .|. .  .   | |.. |.||  ||   .  ||. .     . .|   ||.|||||  |
cdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.|
grtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqt

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2-149 1.6e-21 71.7 In-house 131-284 (325) alignment
Range on Protein: 2-149
Range on HMM: 131-284/325.0
CCYQYWRES--DTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-----GGGPVVVHCS
 | .|| .   ..  ||   ||    ..   |. |.|...  |.   .  | |||.  |.  || . | |.. ... | . ....     . .|..||||
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

DTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
. | |.||. |.  ||..   |  ||.|.. | .|. .|  | |     ..   .
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-141 2.1e-21 71.3 In-house 132-267 (288) alignment
Range on Protein: 3-141
Range on HMM: 132-267/288.0
CYQYWRESDT-ISFGEYFVKCLLSKDCNGYIERKLHIRsdkNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSG
| .|| ..|.   .|.  |. . ||. . ...||| .     . .  .. |.| . || .|| .  . .|.... |   .|.   ||..||||. | |.|
CeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtg

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVC
.. ..  .... ..| ..||. . . .|....  | ||  
tFialdalidaveeedyiDvagtvaklRkqRallvqtlkq

subfamily_PTPRB_pd Subfamily PTPRB 3-140 1e-20 69.0 In-house 136-272 (293) alignment
Range on Protein: 3-140
Range on HMM: 136-272/293.0
CYQYWRES-DTISFGEYFVKCLLSKDCNGYIERKLHIRSdknDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRS
| .|| .  ... .|.  |. . ... . .. |.|.|.    .... .| |.. | ||  ||  ...|.|. .  | ... ..   .|.|||||  | |.
CeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLV
|.. ..   |.. . | .||.| .  ..|...   | |  
GtfialdrllqaieeedyvdifgivaelReeRnllvqtek

PTPc_DSPc_SM00012 50-148 1.1e-20 69.1 In-house 2-102 (105) alignment
Range on Protein: 50-148
Range on HMM: 2-102/105.0
VVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLVCIKIMMM
| ....|.||  || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..|.|.|...| . ||.||. |..|...||.|.|.    ....
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

M
.
a

subfamily_CG7180_pd Subfamily CG7180 3-138 1.3e-20 68.3 In-house 126-275 (296) alignment
Range on Protein: 3-138
Range on HMM: 126-275/296.0
CYQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSD------K---NDSSSWDVVQFQVTNWPT-DGVIREPRTVLQVIDDVIHRQQKI----GGGP
. .|| .     .|| ||. . .|       |....         .    .     | .||.| |.  | |     ......  |   ..|.      ||
ypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegP

VVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
|||..|| .||||||... ..||. . |. ||||.  | .|||.|. | .
vvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven

subfamily_PTPN3_pd Subfamily PTPN3 3-138 1.4e-20 68.4 In-house 126-260 (280) alignment
Range on Protein: 3-138
Range on HMM: 126-260/280.0
CYQYWRE-SDTISFGEYFVKCLLSKDCNGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSG
|.||| | .|....||. |||  ..  . |. |.| .. ||. . .  ..|.| ..||  ||  ..  .|.... | .....    |||||||  . |.|
ChqyWPetedeleygefsvkcekedetksyvlrelvlk.dketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
|.  . .||    |.  | . .. . .|  .   | |
vlilletalalieaaepvypldivrtmrdqramlvqt

subfamily_PTPN23_pd Subfamily PTPN23 3-149 4.1e-20 66.8 In-house 125-276 (288) alignment
Range on Protein: 3-149
Range on HMM: 125-276/288.0
CYQYW--RESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDsSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIH---RQQKIGGGPVVVHCSDTV
. .||  .. .| .||.. | .   .. . ..||.|...  ..|    .|.  |.|.||  ||   | |.||..| | .    .|.    |.|||||  |
vdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGv

SRSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
 |.||.. |  |...  | .|..|. || . .|. .   | .   .| .. ..
gRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 3-150 8.6e-20 65.9 In-house 134-276 (315) alignment
Range on Protein: 3-150
Range on HMM: 134-276/315.0
CYQYWRESdTISFGEYFVKCLLSKDCNGYIERKLhirSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGV
. .|| .   . .|.. |     .  . |  | |   |   ..   .|||...| ||. || .   .....|  |   ...   |..|||||. | |.| 
aekywpdk.kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
.....  |.| .|| ..||... . ||. . ..| ..   . .  ...
fitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall

subfamily_PTPN12_pd Subfamily PTPN12 3-146 8.8e-20 65.7 In-house 125-270 (290) alignment
Range on Protein: 3-146
Range on HMM: 125-270/290.0
CYQYWRES--DTISFGEYFVKCLLSKDCN-GYIERKLHIRSDkndSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSR
| .|| |.  ... |||. |..   | .. ... | |... .   . |  | ||. |.||  || . . ..|..|..| ..|.     |.|||||  | |
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGr

SGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLVCIKIMM
 |. ... .. |. ||| .   .|||..  ..|. .. .| |    ... 
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvy

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 3-139 2.2e-19 64.6 In-house 115-254 (274) alignment
Range on Protein: 3-139
Range on HMM: 115-254/274.0
CYQYWRESDTI----SFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSswdVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDT
| .|. ..  .     .|.  .|    ...|.|  ||| ... ..  |   |. .  |.||   . ....|.|.....| . ...     .|||||||  
CavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
. | |.. ..|||. | ..|.||||....  .|  . | | | 
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 3-150 1.3e-18 61.9 In-house 106-261 (270) alignment
Range on Protein: 3-150
Range on HMM: 106-261/270.0
CYQYWRES--DT--ISFGEYFVKCLLSKDCNGYIERKLHIRsdkNDSSSWDVVQFQVTNWPTDGVIREPR------TVLQVIDDV-IHRQQKIGGGPVVV
| .|| ..  ..  ...|.  |  | ..  .||| ..|...   .....  .| |. ..|| .|| ||.        .|... .|  .....  ..|..|
CerYWpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

HCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
|||. | |.|.   . ||..  . .. ||| .. . .|. ..  | . . .. .   ..
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv

subfamily_PTPN9_pd Subfamily PTPN9 3-131 2.4e-18 61.2 In-house 127-268 (297) alignment
Range on Protein: 3-131
Range on HMM: 127-268/297.0
CYQYWR--ESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQ------------KIGGGP
| |||   | ....||.. |. .  .  . | .|.|.|.  |..  |  |. ||.. ||  || ..  ..|.|.. | ..|             .. | |
cgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktee.srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPP

VVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRS
.|||||  . |.| .... |.|.. . .|.|||... | .|  
ivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtq

0051429 (Phosphotyrosine protein) phosphatases II 3-148 2.9e-18 62.0 In-house 63-220 (272) alignment
Range on Protein: 3-148
Range on HMM: 63-220/272.0
CYQYWR------------ESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPrtVLQVIDDVIHrqqkigGGPVV
|..||             .  ||..| ..|..|  . .. || |.| ..   . . .  | ... |.||..|| .|.  .|.... . .      ||||.
cdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvl

VHCSDTVSRSGVYCSVSIALEQCKAEGVVD--------VFQVTKSVRRSKPGAVTTLVCIKIMMMM
||||  ..|.|... . . |..  .| .||        .... . .|.  |||| |   ..  .. 
vHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2-138 3.7e-17 57.3 In-house 86-224 (237) alignment
Range on Protein: 2-138
Range on HMM: 86-224/237.0
CCYQYWRESDT-ISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSR
 |..|| ..|   ..| . |     ..   |  | | .    .      . |.| | ||  || ..  ..|.   ..|.| ...   || ..|||  | |
kchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.|..  .   | |.| . |||...  .|.   .|  . |
tgiflvidamlrqakekkvvdiynyvysieedrpyiiqt

subfamily_PTPN13_pd Subfamily PTPN13 3-138 4.2e-16 54.0 In-house 119-254 (273) alignment
Range on Protein: 3-138
Range on HMM: 119-254/273.0
CYQYWRESD--TISFGE-YFVKCLLSKDCNGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSR
| .|| ||   ..   . . |. |  .. .|.  |.|... |.. . | .|.... ..||  || ...  .||..  | . |.    ||.|||||  . |
chrywPesknkklkvsnrlevellkvqkldgfvvralavk.dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
||.. .. ..|.  . .  .|| .. ...|. . | | |
sGtlitidvvlglierdkefdvkeivrklreqrqgvvqt

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4-154 4.6e-16 53.3 In-house 129-279 (439) alignment
Range on Protein: 4-154
Range on HMM: 129-279/439.0
YQYWRESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDS-SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
|.||  .. . .|.  |..    .   |. | ...  ... .     |.||. . ||   |  .   ||. .  .   ..|   ||||||||  | |.| 
ykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLvCIKIMMMMMIMMIV
  .. ||||| |.|  ||.  . | .|. .   | .| |  ...   ..  .
iialdialeqlklenkvdikgivkvlrkqrkqmvqal.cqyvfiynavledi

0036282 (Phosphotyrosine protein) phosphatases II 2-139 2.4e-15 52.1 In-house 53-156 (174) alignment
Range on Protein: 2-139
Range on HMM: 53-156/174.0
CCYQYWREsdtisfgeyfvkcllskdcngyierklhirsdKNDSSSWDVVQFQVTNWPTDGVIREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 |..|| |                                . .. .  ..|.. ..|| .||   .  .|.... | . ... .||||.||||  |.|.|
kcinywpe................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtG

VYCSVSIALEQCKaEGVVDVFQVTKSVRRSKPGAVTTL
. .   . | . . |..||.... ...|. .||.|.| 
tlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

subfamily_PTPN1_pd Subfamily PTPN1 3-150 7.9e-15 49.3 In-house 113-268 (290) alignment
Range on Protein: 3-150
Range on HMM: 113-268/290.0
CYQYWRES---DTISFG--EYFVKCLLSKDCNGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSDT
|.||| .    ... .   .. || .  .. . |. |.|..  ...   . ....|  | ||  || . | . |. . .| .    .   ||.|.|||  
caqywPqgeeekellledtklkvkliseerksyytvrllele.nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMI
. ||| .| |   | . ....    ||. .|   .|. . | . |   ..   . ..
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylail

fn3 Fibronectin type III domain 396-468 1.4e-14 47.2 Pfam-A 2-78 (85) alignment
Range on Protein: 396-468
Range on HMM: 2-78/85.0
APSSLTVVNKTATTITVSWTTLD--SSDADGYVVNVTDSDTVQ---TVQVEGNSInTVTLNGLRGGTTYSITVRAYKE
||. |.| . |.|..|.||.  .  ... .|| | . .... .   ...|....  .|||.||. ||.|...|.|...
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavng

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 3-151 1.8e-14 48.1 In-house 136-279 (290) alignment
Range on Protein: 3-151
Range on HMM: 136-279/290.0
CYQYWR--ESDTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSRS
| ||.   | ....|||. | | ...| .  | .|.    ||..  .  .  ...  ||   |     ..|...  .  |.     ||||||||  . |.
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrt

GVYCSVSIALeQCKAEG-VVDVFQVTKSVRRSKPGAVTtlVCIKIMMMMMIM
| . .. ..| |.  .|  .|. .. ...|.|. ..|   | |. .... |.
Gtfvaievgl.qilldGkeldlldlvralrnsrlnsvq..vdiqylalveil

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3-138 2.2e-14 48.2 In-house 94-226 (239) alignment
Range on Protein: 3-138
Range on HMM: 94-226/239.0
CYQYWRESdTISFGEYFVKCLLSKDCNGYIERKLhIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGV
|.||| .| |  . .  |    ..    || | . . |.  ..    | |...| ||  || .   .|| .    | ..   |  | |.|||  | |.| 
chqywpds.tskycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.  .   | |.| .  ||.|.  |..|  .|  | |
flvidamlrqakkqktvdifnyvkairedrphmvqt

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3-139 2.2e-14 48.2 In-house 93-226 (239) alignment
Range on Protein: 3-139
Range on HMM: 93-226/239.0
CYQYWRESdTISFGEYFVKCLLSKDCNGYIERKLhIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGV
|.||| .| |  . .  |    ..    || | . . |.  ..    | |...| ||  || .   .|| .    | ..   |  | |.|||  | |.| 
chqywpds.tskycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
.  .   | |.| .  ||.|.  |..|  .|  | | 
flvidamlrqakkqktvdifnyvkairedrphmvqts

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 46-139 2.5e-14 47.4 In-house 87-424 (440) alignment
Range on Protein: 46-139
Range on HMM: 87-424/440.0
SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIGGGPVV-------------------------------------------------------
 |  . |..   ||  || .    ||..|.|| . |.| | ||..                                                       
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

----------------------------------------------------------------------------------------------------
                                                                                                    
heavlegllcgdtliledditerveqiqwpnphtdksplqqefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsv

-----------------------------------------------------------------------------------------VHCSDTVSRSG
                                                                                         |||   .  ||
tfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesg

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
|.|.|   ||| . .| .||||  . .| |.|  | ||
vfctvmncleqlnndgaidvfqnlrllrlsrpnfvptl

0041856 (Phosphotyrosine protein) phosphatases II 2-149 1.8e-13 46.0 In-house 66-167 (182) alignment
Range on Protein: 2-149
Range on HMM: 66-167/182.0
CCYQYWResdtisfgeyfvkcllskdcngyierklhirsdknDSSSWDVVQFQVTNWPTDGVIRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSG
....||                                    .     ..|.. ..|| .||   ....|. |..|..      ||||.||||  |.|.|
teelywp...................................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtg

VYCSVSIALEQckaeGvVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
...   . ...    | |..... | ||. .||.|.|.  . . ....
tlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlal

subfamily_PTPN14_pd Subfamily PTPN14 3-153 5.9e-13 43.5 In-house 135-296 (300) alignment
Range on Protein: 3-153
Range on HMM: 135-296/300.0
CYQYWRES----DTISFGEYFVKCLLSKDCNGYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDV---IH-RQQKI----GGGPVV
...|. ..    .|. ||.. |   .|.| . .| ..|...     .   .|. .| |.|| .|| ..... |. ...|    .  ....       ||.
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlps.keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMI
||||. | |.||   . . ..  . . ..|. .| . .|. .   | ||   | .  ..| ..
vhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 40-140 6.9e-13 42.7 In-house 125-223 (392) alignment
Range on Protein: 40-140
Range on HMM: 125-223/392.0
SDKNDSsSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
 || |.    | ||..|.|| ..| .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | 
gdkgdd.artvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtk

V
 
e

subfamily_PTPRN_pd Subfamily PTPRN 3-147 7.6e-13 42.8 In-house 142-286 (297) alignment
Range on Protein: 3-147
Range on HMM: 142-286/297.0
CYQYWRESDTISFGEYFVKcLLSK--DCNGYIERKLHIRSDKNdSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRS
|..|| .  .  .. | |. |.|.   |. |. | ....  .. | .  | ||    ||  ||  .....|.    |  .  .    |.|||||| . |.
ckrywpdeGsevyhiyevh.lvsehiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrt

GVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMM
|||. . . |..  |    .|.    . .|  .|| | |   ......
GvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 3-153 1.5e-12 42.2 In-house 113-259 (290) alignment
Range on Protein: 3-153
Range on HMM: 113-259/290.0
CYQYWRESD--TISFGEYFVKCLLSKDCNGYIERKLHIRSDknDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRS
| .| .||    . |.   |||      .. ..|.| .. |  |   . |   .. .| .  | ....|.|..|. |  ..      ||.||| | .|||
CakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd..deeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrs

GVYCSVSIALEQCK-AEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIMMI
 .  .. ..       .| | . .| |..|. .  |.|.      ..  .....
AalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivlla

0043147 (Phosphotyrosine protein) phosphatases II 48-139 1.5e-12 43.1 In-house 63-147 (172) alignment
Range on Protein: 48-139
Range on HMM: 63-147/172.0
WDVVQFQVTNWPTDGVIrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaEGVvDVFQVTKSVRRSKPGAVTTL
  ..|.. ..||  ||   .. .|.... . .....  ||||.||||  |.|.|. .   . |     .|. ..... . ||. .||||.. 
rlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnp

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 20-139 1.8e-12 41.8 In-house 130-245 (267) alignment
Range on Protein: 20-139
Range on HMM: 130-245/267.0
VKCLLSKDCNGYIERKLHIRSdKNDsSSWDVVQFQVTNWPTDGVirePRTVLQVIDD-VIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV
|.  | |. | |    | ..  ||. |. .|. .   .|  .      .  |. .   . . | . |. |.||.||| | ||| .  .   ||. | |||
vehslekeendyqiitlelkf.kne.sahnvtlyyykkwnintn...nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegv

VDVFQVTKSVRRSKPGAVTTL
.|.|.  . .|  ..| | |.
sdifdflrkirsqriglvdtk

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 3-149 3.1e-12 40.9 In-house 122-273 (287) alignment
Range on Protein: 3-149
Range on HMM: 122-273/287.0
CYQYWRESD-TISFGEYFVKCLlSKDC--NGYIERKLHIRsDKNDSSSWDVVQFQVTNWPTDGVIRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSD
||.|| | .  .  | | |  | ..|     |  | | .  | .   .  | |... .|| ...        | ||.| . .  ...  . ||.|||.. 
cykywPerevPmrvGGysvvll.dydikePeygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv

TVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMM
 . |||.. .. . ... .  | ||| .|   .|  . . | . | .....  .
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal

0048076 (Phosphotyrosine protein) phosphatases II 38-143 1.2e-11 40.0 In-house 36-133 (145) alignment
Range on Protein: 38-143
Range on HMM: 36-133/145.0
IRSDKNDSSsWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiALEQCKAEGvVDVFQVTKSVRRSKPGAVT
. |.... .   ..|.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.|...    |.  .. .| |..... . ||.  ||||.
ltselelle.rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavp

TLVCIK
.   ..
npgqlr

0051082 (Phosphotyrosine protein) phosphatases II 5-141 1.7e-11 39.4 In-house 51-141 (151) alignment
Range on Protein: 5-141
Range on HMM: 51-141/151.0
QYWRESDtisfgeyfvkcllskdcngyierklhirsdkndsssWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYC
.|..| .                                     .|.......||. |.   . .||.... ...     ..|||.||||  ..|.|. .
eylpelg....................................ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlv

SVSIALEQckaegvVDVFQVTKSVRRSKPGAVTTLVC
 . . |..      |..... . .|.. ||.|..   
alylmllg......vsleealeeyrlkrpgvvqpnqq

0048179 (Phosphotyrosine protein) phosphatases II 40-140 4.8e-11 38.1 In-house 48-132 (144) alignment
Range on Protein: 40-140
Range on HMM: 48-132/144.0
SdkndssswdVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIALeqckAEGvVDVFQVTKSVRRSKPGAVTTL
          ..|.. ..||  ||   .  .|.... . . ..   ||||.||||  |.|.|...   . .     .| ...... . ||.  ||||.. 
e.........giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnp

V
 
g

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 44-166 7.4e-11 36.0 In-house 184-299 (302) alignment
Range on Protein: 44-166
Range on HMM: 184-299/302.0
DSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVciK
.     |  .. . ||  |  .|. | |...      ...     |.||||  | |.|   ..   .. |. . | |. .. . ||. . ||| .    .
kkvkktvdilafsawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeq..q

IMMMMMIMMIVLFRINTVQYMKS
.. .....   |    .| |..|
liylllcvtkglmekagvlylrs

0046846 (Phosphotyrosine protein) phosphatases II 3-141 7.5e-11 37.6 In-house 65-161 (176) alignment
Range on Protein: 3-141
Range on HMM: 65-161/176.0
CYQYWRESDTISFgeyfvkcllskdcngyierklhirsdkndssswdvvQFQVTNWPTDGVIREpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGV
|..|| |  . ..                                    |.....||  ||    . .|.... .  ....  ||||.||||  ..|.|.
cpnywpeleklgi....................................qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgt

YCSVSialeQCKAEGVVDVFQVTKSVRRSKP-GAVTTLVC
..        .. |  ..|... . ||. .| |||.|   
lvaay....llelekglsveealalvreqRplgavqtpeQ

0049260 (Phosphotyrosine protein) phosphatases II 7-139 8.4e-11 37.3 In-house 55-136 (152) alignment
Range on Protein: 7-139
Range on HMM: 55-136/152.0
WresdtisfgeyfvkcllskdcngyierklhirsdkndssswdvvQFQVTNWPTDGVIREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSV
.                                            |.. ..|| .||   .  .|.... . .. ..  ||||.||||  |.|.|...  
i............................................qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaa

SIALeqckaeGVVDVFQVTKSVRRSKPGAVTTL
 . |        |..... . ||. .||||.. 
ylml......lgvsleeavalvrekRpgavpnp

0044763 (Phosphotyrosine protein) phosphatases II 37-145 8.1e-09 30.9 In-house 75-163 (178) alignment
Range on Protein: 37-145
Range on HMM: 75-163/178.0
HirsdkndssswdvvqFQVTNWPTDGVIREP-RTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGVvDVFQVTKSVRRSKPgA
.               .|. ..|...    . .  .. . . |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .
g...............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.i

VTTLVCIKIM
|..   .. .
vpnpgqlrqL

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 47-179 2.3e-08 28.1 In-house 214-343 (350) alignment
Range on Protein: 47-179
Range on HMM: 214-343/350.0
SWDVVQFQVTNWPTDGVIREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKaegvvDVFQVTKSVRRSKPGAVt
 . | |.|| ||.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....   |.. .     .. ..||  |...  |  
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfe.....ilenltkesrkldvaak.

tlvcIKIMMMMMIMMIVLFRINTVQYMksDTYVYNNNCIVFY
    .. .. ...  .   ||. || .  | ...  ... ||
....trDlisiivnelrkqrismvqnl..dqfifiYeallfy

0049772 (Phosphotyrosine protein) phosphatases II 48-139 9.4e-08 27.6 In-house 178-266 (314) alignment
Range on Protein: 48-139
Range on HMM: 178-266/314.0
WDVVQFQVTNWPTdGVIREPRTVLQVIdDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaeGVvDVFQVTKSVRRSKP-----GAVTTL
  ....  ...|  |    .. ..... ..|..     ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .|
rlgikylripvpD.gsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieql

subfamily_CG42327_pd Subfamily CG42327 86-139 1e-07 25.9 In-house 247-301 (319) alignment
Range on Protein: 86-139
Range on HMM: 247-301/319.0
GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTL
 ||.|||||| | |.|.  .  ||... .     ||. |.  |||| .  || | 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltk

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 46-140 1.5e-07 25.7 In-house 93-191 (199) alignment
Range on Protein: 46-140
Range on HMM: 93-191/199.0
SSWDVVQFQVTNWPTDGVIREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLV
|. .. ..| | |           |  |.   .| .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...| 
streishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslq





subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 46-138 1.5e-07 25.7 In-house 174-262 (307) alignment
Range on Protein: 46-138
Range on HMM: 174-262/307.0
SSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTT
 |  . ..| .|||  || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |
ksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqt

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 46-140 1.5e-07 25.8 In-house 92-190 (198) alignment
Range on Protein: 46-140
Range on HMM: 92-190/198.0
SSWDVVQFQVTNWPTDGVIREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLV
|. .. ..| | |           |  |.   .| .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...| 
streishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslq





subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 53-151 3.1e-07 24.3 In-house 195-288 (310) alignment
Range on Protein: 53-151
Range on HMM: 195-288/310.0
FQVTNWPTDGVIREP-RTVLQVIddviHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIKIMMMMMIM
 .  |||  ||  |   || | .      |  .  ||.|||||  . | .| ... ..... .    ||. .|   ...|.   . | .   |. ...|.
ikwpnwpdrgvpdekchtvpqrl....laq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii





subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 44-121 5.6e-07 23.2 In-house 214-291 (349) alignment
Range on Protein: 44-121
Range on HMM: 214-291/349.0
DSSSWDVVQFQVTNWPTDGVIREPRTVLQV-------IDDVIHRQ--QKIGGGPVVVHCSDTVSRSGVYCSVSIALEqckaegvvdV
 .. . ..|.|| ||.  ... .| ..||        |||   |.  ..    ...||||    |.||.. . . |.         .
vekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls.........i

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 49-157 6.7e-07 23.6 In-house 172-274 (288) alignment
Range on Protein: 49-157
Range on HMM: 172-274/288.0
DVVQFQVTNWPTDGVIREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLVCIkIMMMM
 | .  . .|. |||  .  . |.... . .  ||    |.|||.|  | |.|    . ||||. . .  . . .. .. | ..  |..|     . .  
ivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqy.lyvhr

MIMMIVLFR
...  .|..
cvleelllk

subfamily_ptpA1_pd Subfamily ptpA1 44-111 2.3e-06 21.6 In-house 182-254 (418) alignment
Range on Protein: 44-111
Range on HMM: 182-254/418.0
DSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDDVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIALE
.  . |. |.|   ||   .    . . |..  .  ||..|        |..||||  | |.| .|.  | ..
egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 31-145 4e-06 20.8 In-house 164-273 (301) alignment
Range on Protein: 31-145
Range on HMM: 164-273/301.0
YIERKLHIRSDKNDSSSWDVVQFQVTNWPTDGVIREPRTVLQVIDdVIHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRR
 ..|.|...   .. ..  |. .| ..|.  || .    . .... .. . .|    |.|||||. . ||  . .  .   . .|.  ... .  | .| 
iskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlre

SKPGAVTTLVCIKIM
 .  .| |   .  |
hrwngvqtnsqlywm

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 90-136 4.8e-06 20.9 In-house 2-48 (69) alignment
Range on Protein: 90-136
Range on HMM: 2-48/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAV
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmv