Gene PTPRD-64 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP122_AA protein Get Run
AqueP122_AA_1076-1242 phosphatase_domain Get Run
AqueP122_AA_1236-1430 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1239-1434 3.7e-106 349.2 In-house 78-298 (301) alignment 
Range on Protein: 1239-1434
Range on HMM: 78-298/301.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYWTGPKTHDDFVVEITNEIKS---------------------NGYMER
| ||.||..||.||.||..|..|||..|...|...|||.......    |. ||   ..... ....|.....                     |||.||
idgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyier

MFKVSFDKESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVT
.|||. ||.|..||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
kfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVt

TLEQYTSIYDVIDMYLQMNSI
|||||||||||||||||.||.
TLeqytsiydvidmylqlnst
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1239-1432 8.9e-84 276.2 In-house 82-286 (305) alignment 
Range on Protein: 1239-1432
Range on HMM: 82-286/305.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC----GEEDCCYPYWTGPKTH----DDFVVEITNEIKSNGYMERMFKVSF---DKESRNVL
. ||..| ..|.||.|..|||.|||..||..||| ||||.    |..|.|. ||.. ||.    ..|.||...| . ..|.|| .|.|.   |||||.||
vdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvl

QLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
|.|.||||..||.... ..|..|..| ..|.|  | |..||||..|.|.||...|.| ||..|.|.|||||.|.|..|......|.||.||....|..| 
qyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde

YLQMN
...  
litcg
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1076-1240 8.2e-74 243.0 In-house 2-163 (301) alignment 
Range on Protein: 1076-1240
Range on HMM: 2-163/301.0
ISDLGTHVASYHSDNntaFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMELCEREYINATYIDGYSSANKFIAAQGPMKKTL
..|||||||..||..   |..||.||..||| ..|||.||.||..||||||..||...|.|..|||..||.||||||.||||||...|||||||||||||
ledlgthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktl

VDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSIT
|||||||||||||||||||||||||||||||||||..|||||||||.||||.|||.||||||...
vdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqln
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1239-1431 8e-63 207.1 In-house 79-280 (287) alignment 
Range on Protein: 1239-1431
Range on HMM: 79-280/287.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTGPK--THDDFVVEITNEIKSNGYMERMFKVSFDK---ESRNVLQL
| ||.||.|||||.||| ||.|.|||.| | .|.||||||     .|. || ||.  |  .  .. .|..|| ...||.|| ..|  ..   . ..| | 
idgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqy

QVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|.|.|.. | | ||.|.| ||.. .. |.| | ...|||||||| ||...|.. .....|| |||.||||| |  |  |||.| | |||. |.|.. .||
qitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl

QM
. 
ds
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1239-1430 1.7e-62 205.9 In-house 84-284 (290) alignment 
Range on Protein: 1239-1430
Range on HMM: 84-284/290.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTGP--KTHDDFVVEITNEIKSNGYMERMFKVSFDKE---SRNVLQL
| ||.||...|..|.|..||..||||.|.. ||..||||.     ... |. ||.    |. . | ....|| . |.|.|| ..|  ...   ...| |.
ikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqy

QVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|.| |...| | .| |.|.||  ... | | | ...||||||||.||.|.|.. .....|| |||.||||| |  |  ||| |.| .||  |....  ||
qitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl

Q
.
d
0050432 (Phosphotyrosine protein) phosphatases II 1239-1431 3.4e-57 189.5 In-house 99-301 (308) alignment 
Range on Protein: 1239-1431
Range on HMM: 99-301/308.0
ITGY--REKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYW-----TGPKTHDDFVVEITNEIKSNGYMERMFKVSF--DKESRN
..||  . .|.||..|.|..||| |||.|. ...|. ||||. ...     |..||      |......|.|....| . ..|. | .....  |.||| 
vdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrt

VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
| ... |.|| .||  .|. .|. .. | ...   .|||.|||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|.|||  .|...
vthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyral

DMYLQM
 .||. 
leylkl
0036941 (Phosphotyrosine protein) phosphatases II 1239-1431 3.5e-55 182.8 In-house 71-279 (297) alignment 
Range on Protein: 1239-1431
Range on HMM: 71-279/297.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYW----TGPKTHDDFVVEITNEIK--SNGYMERMFKVSF--DKESRNV
..||. ||.||..| |..||| |||.|. ...|. ||||. ...     |..||     ...|..||.|. ... .  ...|  | ..|..  ..||| |
vdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtv

LQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
 ....|.|| .||   |...|. |. | ...... .||||.||||. |.|||... . . |.| .    || ||.... | .|. .||||.|||||  .|
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly

DVIDMYLQM
... ..|. 
eallellkk
0051299 (Phosphotyrosine protein) phosphatases II 1239-1429 4e-55 182.7 In-house 85-286 (288) alignment 
Range on Protein: 1239-1429
Range on HMM: 85-286/288.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYW--TGPKTHDDFVVEITNEIKSNGYMERMFKVS------FDKESRNV
|.||. ||.||..| |..||| |||.|. ...|. ||||.....     |..||   |..|..|..|....| . ..|. | ..|.      .|.|||.|
idgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtv

LQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
 ....|.|| .||   |. .|. . .|.. ..  ||||||||||. |.|.|... . . ||| ..||.|||... | .|. .||.|.|.|||  .|... 
thfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall

MYL
.||
eyl
0046845 (Phosphotyrosine protein) phosphatases II 1239-1431 1.6e-54 180.6 In-house 65-276 (284) alignment 
Range on Protein: 1239-1431
Range on HMM: 65-276/284.0
ITGY-----REKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYWT---GPKTHDDFVVEITNEIKSNGYMERMFKVSF---DKES
..||     . |..||..| |..||| |||.|. ...|. ||||.....     |..||    ...|..|| |....| . ..|. |......   ..||
vdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytges

RNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK-IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYT
| | ....|.|| .||  .|. .|. ...| . ...  ||||.|||||. |.|.|... . . ||| ..||   .|||... | .|. .||.|.||||| 
rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyr

SIYDVIDMYLQM
 .|... .||..
fvyealleylkl
0047943 (Phosphotyrosine protein) phosphatases II 1239-1429 1.1e-53 177.8 In-house 70-272 (273) alignment 
Range on Protein: 1239-1429
Range on HMM: 70-272/273.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYWTG-----PKTHDDFVVEITNEIKSNGYMERMFKVSF--DKESRNVL
..||. ||.||..| |..||| |||.|. ...|. ||||. ...     |..||       ..|...| |....| . ..|. | .....  ..||| | 
vdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvt

QLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
....|.|| .||   .  .|. |..| . .... ..||||||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|.|||  .|... 
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall

MYL
.||
eyl
0040438 (Phosphotyrosine protein) phosphatases II 1239-1432 5.6e-53 175.6 In-house 79-279 (317) alignment 
Range on Protein: 1239-1432
Range on HMM: 79-279/317.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYW--TGPKTHDDFVVEITNEIKSNGYMERMFKVSF--DKESRNVLQLQ
..|...||.||..|.|..||| |||.|. ...|. ||||. .|..    |..||   ...|..||.|....|.. .|.  | ..|.   |.||| | ...
vdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfh

VTDWPQDGVVREPRTVLQVIDDVIHRQQkiG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 |.|| .||   |...|. .. | . ..  . ||||.||||. |.|.|... . . |||.. || |||... | .|. .||||.|.|||  .||.. .||
ytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

QMN
. .
krk
subfamily_PTPRD_pd Subfamily PTPRD 1074-1239 8.8e-53 174.8 In-house 5-166 (564) alignment 
Range on Protein: 1074-1239
Range on HMM: 5-166/564.0
VSISDLGTHVASYHSDNNTAFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPMKK
.....| .|||. ...... |...|... .|.  ....   ..||. ||..|| .||.  .||.| .. |  . .||||..|||| . ...||.|||...
ipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegde..gsDYINAsfidgyrkrkayIAtqgPlae

TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGrAeSEEFGPFSVTLVDEQVLPDFVIRSI
|. ||||..|...  .|||.|.|.| .| ||..|||.    .|..| . |||..|. | |..||..
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtf
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1074-1239 9.3e-53 174.3 In-house 4-166 (305) alignment 
Range on Protein: 1074-1239
Range on HMM: 4-166/305.0
VSISDLGTHVASYHSDNNTAFNQQYQELYTGeDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPMKK
....|| ... . ..........||..||.  . .. || .|.||  ||.|.| ..|.. | |..|....  ...||||.|.|||.. .|.|.||||.|.
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlkn

TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSI
|..||||||..||...|||.|.|.|| |.||.||||.  .|..|||.|||.| .|.  .|...| .
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRkl
0039614 (Phosphotyrosine protein) phosphatases II 1239-1431 1.2e-52 174.6 In-house 93-291 (297) alignment 
Range on Protein: 1239-1431
Range on HMM: 93-291/297.0
ITGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC---CYPYW--TGPkTHDDFVVEITNEIKSNGYMERMFKVSFDKESRNVLQLQVT
..||.  .|.||..| |...|| |||.|. ...|..||||. ....   |..||  .|  |..||.|. ..... .||. | ..|. ..||| | ..|.|
vdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqyt

DWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
.|| .||   ....|.... | .....  .||||.||||. |.|.|...   . |||.. || |||... | .|. .||||.|..||  .||.. ..|. 
gwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1074-1239 1.3e-52 173.5 In-house 2-166 (290) alignment 
Range on Protein: 1074-1239
Range on HMM: 2-166/290.0
VSISDLGTHVASYHSDNNTAFNQQYQELYTGED-LPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMELCEREYINATYIDGYSSANKFIAAQGPMK
. ....| .||  |. .|. |..|.. | .||    .|||....||. |||.|| .||.. |.|..... . |. |||||.||.||. ....||.|||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraESEEFGPFSVTLVDEQVLPDFVIRSI
.||||||.||||||   |||.|| .|  | || ||||.   .....|.||..|..|..| ....| .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1239-1431 6.3e-52 171.7 In-house 92-292 (298) alignment 
Range on Protein: 1239-1431
Range on HMM: 92-292/298.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED----CCYPYWTG--PKTHDDFVVEITNEIKSNGYMERMFKVSFDK--ESRNVLQLQ
. .|... |||..| |...|| |||.|........||||   |.     .  ||     .|.... |.. .. .   .. | .|||  |  ..|.| ||.
lhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlh

VTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.| ||. || .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  .|.
ftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

M
 
s
subfamily_PTPRD_pd Subfamily PTPRD 1239-1431 7e-52 171.8 In-house 84-283 (564) alignment 
Range on Protein: 1239-1431
Range on HMM: 84-283/564.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED----CCYPYWTG--PKTHDDFVVEITNEIKSNGYMERMFKV--SFDKESRNVLQLQ
| |||...|.| .| |...|..|||.|. ....| ||||   |.     |  ||    ..|.....|....| . . |. | ||.  . ..|||.| | .
idgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFh

VTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
 |.||. ||  .....|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | | |||  |...|  .|.
FtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala

M
.
c
Y_phosphatase Protein-tyrosine phosphatase 1239-1425 1.7e-51 170.3 Pfam-A 35-233 (235) alignment 
Range on Protein: 1239-1425
Range on HMM: 35-233/235.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYWT----GPKTHDDFVVEIT-NEI-KSNGYMERMFKVSFDKES---RN
..||.||..||..| |...|. |||.|....||..||||. .|.     | .||     ...|..|. ||.. .|  ....|. | .... .||.   | 
vkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekre

VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
| ||..|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
vkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1239-1425 1.7e-51 170.3 In-house 35-233 (235) alignment 
Range on Protein: 1239-1425
Range on HMM: 35-233/235.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYWT----GPKTHDDFVVEIT-NEI-KSNGYMERMFKVSFDKES---RN
..||.||..||..| |...|. |||.|....||..||||. .|.     | .||     ...|..|. ||.. .|  ....|. | .... .||.   | 
vkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekre

VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
| ||..|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .|...||.|..||||  .|..|
vkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
DSPc_SM00195 1239-1429 1.8e-51 170.4 In-house 62-262 (263) alignment 
Range on Protein: 1239-1429
Range on HMM: 62-262/263.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYWTGP----KTHDDFVVEITNEIKSN-GYMERMFKVSFDK--ESRNVL
|.|...|...|..| |...||.|||.|... ||. ||||. ||..    |. ||       .|.... |......| .  .  | .......  |.|.| 
ikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvt

QLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
|.|...||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  
qyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

YL
|.
yi
PTPc_SM00194 1239-1429 1.8e-51 170.4 In-house 62-262 (263) alignment 
Range on Protein: 1239-1429
Range on HMM: 62-262/263.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYWTGP----KTHDDFVVEITNEIKSN-GYMERMFKVSFDK--ESRNVL
|.|...|...|..| |...||.|||.|... ||. ||||. ||..    |. ||       .|.... |......| .  .  | .......  |.|.| 
ikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvt

QLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
|.|...||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  
qyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

YL
|.
yi
0045450 (Phosphotyrosine protein) phosphatases II 1240-1429 4.5e-51 169.8 In-house 101-304 (307) alignment 
Range on Protein: 1240-1429
Range on HMM: 101-304/307.0
TGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYW---TGPKTHDDFVVEITNEIKSNGYMERMFKVS---FDKESRNVLQL
 ||. ||.||..|.|...|| |||.|. ...|..||||......    |..||    ...|...|.|. ..| . .||  | ..|.   ...||| | ..
dgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthf

QVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. |.|| .||   . ..|. |. | . ...  .||||.||||. |.|.|...   . |.| ..||.   ||.... | .|. .||||...|||  .|...
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

DMYL
 ..|
lell
0043336 (Phosphotyrosine protein) phosphatases II 1239-1429 2.5e-50 166.9 In-house 81-277 (278) alignment 
Range on Protein: 1239-1429
Range on HMM: 81-277/278.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYW-TGPKTHDDFVVEITNEIKSNGYMERMFKVS--FDKESRNVLQLQV
..||. .|.||..| |...|| |||.|. ...|. ||||.....     |..||  |..|..||.|. ..|.. ..|. | ..|.   |.||| |.... 
vdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhy

TDWPQDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
..|| .||   . ..|. . .|.....   .|||.||||. |.|.|... . . ||| . || ||.... | .|. .||||.|..||  .|... .||
lgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0040439 (Phosphotyrosine protein) phosphatases II 1239-1429 5.7e-50 165.6 In-house 47-246 (249) alignment 
Range on Protein: 1239-1429
Range on HMM: 47-246/249.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYW--TGPKTHDDFVVEITNEIKSNGYMERMFKVS--FDKESRNVLQLQ
|.||. ||.||..| |...|| |||.|. ......||||. .. .    |..||   |.....||.|. ........|. |.....   |.||| ||..|
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

VTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
.|||| .||   . ..|. |. | . ....  ||||.||||. |.|.|...   . ||| . |. ||.... | .|. .||||...|||  .|... ..|
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1239-1431 1e-49 164.4 In-house 82-282 (318) alignment 
Range on Protein: 1239-1431
Range on HMM: 82-282/318.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYWT--GPKTHDDFVVEITNEIKSNGYMERMFKVSFD--KESRNVLQLQ
| |||.|.|.| ||.|. .|..|||.|. . . . ||||  ||.     .  ||   |...... |||...|.... |. | |||. .  .|||.| | .
idGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyh

VTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.|.||. ||  .. ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | .||. ||||.  .|.
ytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala

M
 
s
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1239-1430 5.3e-49 161.7 In-house 45-243 (250) alignment 
Range on Protein: 1239-1430
Range on HMM: 45-243/250.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG---EEDCCYPYWT--GPKTHDDFVVEITNEIKSNGYMERMFKVSFDKESRN--VLQLQV
. ||.|..|||..|.|...|. |||.|....|...||||     .|  .  ||   ..... |  |.. .. .   |. | .|.|  |.. .  | ||. 
lhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhf

TDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
. ||  || .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | | |||||.| |..|. .|.||..|||| ..| .|  .|.
vvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1239-1432 4.7e-47 155.6 In-house 84-286 (319) alignment 
Range on Protein: 1239-1432
Range on HMM: 84-286/319.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGPK--THDDFVVEITNEIKSNGYMERMFKV---SFDKESRNVLQL
| ||.|...|| .|.|.|||. |||.|. ....| .|||..  .     .  ||.  .  .   ..|.. .| . ..|. | .|.   | . |.|.| . 
idgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhf

QVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
| |.||...| .. ...|... .. . ..|   ||.|||||. | | | .. ... ||. | |||.|||.. . .|  ..  | . |||. ||...  ..
qyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav

QMN
.. 
eag
0042113 (Phosphotyrosine protein) phosphatases II 1239-1429 1.6e-46 154.1 In-house 45-243 (245) alignment 
Range on Protein: 1239-1429
Range on HMM: 45-243/245.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYW--TGPKTHDDFVVEITNEIKSNGYMERMFKVS--FDKESRNVLQLQ
..||| .. ||..| |...|| |||.|. ......||||. ||.     |..||   ...|..||.|. ..| . ..|. | ..|.   |.|||.|....
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

VTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 ..|| .||   ....|.... | . ... ..|||.||||. |.|.|... . . ||| ..|. |..... | .|. .||||.|..||  .|... ..|
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1074-1239 4.1e-46 152.3 In-house 2-161 (287) alignment 
Range on Protein: 1074-1239
Range on HMM: 2-161/287.0
VSISDLGTHVASYHSDNNTAFNQQYQELYT--GEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQkkpnmeLCEREYINATYIDGYSSANKFIAAQGPM
.... .|  ||. |  .|. |..|.. |     ..   |.. ..|||. ||...| ..|.. ..|.       .. .||||..||||.....||.|..||
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPm

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAesEEFGPFSVTLVDEQVLPDFVIRSI
 .|...||.||.....  |||....|| ....| ||||....    .|.....|..|.|  ....| .
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierkl
subfamily_PTPRA_pd Subfamily PTPRA 1239-1433 6.1e-45 148.5 In-house 94-300 (330) alignment 
Range on Protein: 1239-1433
Range on HMM: 94-300/330.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG----EEDCCYPYW--TGPKTHDDFVVEITNEIKSNGYMERMFKVS------FDKESRNV
| ||.||  || || | |.|| |||.|| ..| ..||||      .|. |. ||   |  |. .  ||. .|  .. |  | | |        .|.|| |
idGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlv

LQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
 |.  | ||. ||  ||. .|...  | . .|. .| |.|||||  | |.| .. ..  ||. |||..||||.. | .|  .|  | |.|||. || |. 
rqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvll

MY-LQMNS
 | |  ..
eyylygdt
0051299 (Phosphotyrosine protein) phosphatases II 1073-1239 2.4e-44 147.3 In-house 4-167 (288) alignment 
Range on Protein: 1073-1239
Range on HMM: 4-167/288.0
SVSISDLGTHVASYHSDNNTAFNQQYQELYTGE-DLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNmeLCEREYINATYIDGYSSANKFIAAQGPM
..|...|  .|  .. ...| . ....||.    ||.....  ..|.. ||...| |||   ..|.  ..    .  |||| ||||| . .||||.|||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPl

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSI
..|. ||||..|...   |||.|.| |  . ||.||||.   .|...|...|||..|.||.|...| .
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtl
subfamily_Ptp69D_pd Subfamily Ptp69D 1239-1428 4.5e-44 145.8 In-house 84-285 (307) alignment 
Range on Protein: 1239-1428
Range on HMM: 84-285/307.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYWT--GPKTHDDFVVEITNEIKSNGYMERMFKVSFDK-------ESRN
| ||.||. ||.|| |.|.|. |||.|| . .|  ||||  ...     |  ||.    . ..| .|.. .| | . |..| ..||  |       .||.
ikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrk

VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|.| . | |.   | . .|..|..|. | . ...   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  .
vvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral

DMY
  |
ldy
0045098 (Phosphotyrosine protein) phosphatases II 1239-1430 5.9e-44 145.9 In-house 59-273 (278) alignment 
Range on Protein: 1239-1430
Range on HMM: 59-273/278.0
ITGYreKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYWT--GPKTHDDFVVEITNEIKSNGYMERMFKVS------FDKESRNV
|.||  ...||..| |...|| |||.|. ......||||.....     |..||   |..|..||.|....|   . |  |...|        | |||.|
idgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgv

LQLQVTDWPQDGVVREP--RTVLQVIDDVIHRQQK------------IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVRRSKPG-A
 .|. . ||  ||  .|  . .|.... . .....             .||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|| |
thlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpgla

VTTLEQYTSIYDVIDMYLQ
|..||||  .|... ..|.
vqnleqyrflyefllelll
subfamily_PTPRB_pd Subfamily PTPRB 1071-1239 9.5e-44 144.6 In-house 4-170 (293) alignment 
Range on Protein: 1071-1239
Range on HMM: 4-170/293.0
TCSVSISDLGTHVASYHSDNNTAFNQQYQELY-TGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQG
.  ...... .||.. ..|... |...|.||   |.|  ...  ...|.  ||..|| |||.  . |..  . .  . .|||| ||.||.| ..|||.||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdes..gsDYinanyipgynsprefiatqG

PMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaESEEFGPFSVTLVDEQVLPDFVIRSI
|. .|. ||||..|..|   |||.|.| |. | |||.|||. . |.  .|  .|||| |..| |.|||..
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1076-1239 4.6e-43 142.3 In-house 6-166 (288) alignment 
Range on Protein: 1076-1239
Range on HMM: 6-166/288.0
ISDLgTHVASYHSDNNTAFNQQYQEL-YTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPMKKT
||.. ..||  . .|.| |...|. |   ...  .|.|   .|.. ||..|| ||||. . |.| .. .  . .||||.||||. . .|.||.|||. .|
ispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyidgekkkkkyiatqgPladt

LVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaESEEFGPFSVTLVDEQVLPDFVIRSI
. |||.|....|   |||.|.| || |.|||.|||..  . ...| . ||||... | ||| |..
vndfWelvyenktstivmltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrkl
subfamily_PTPRG_pd Subfamily PTPRG 1074-1233 5.6e-43 142.0 In-house 1-160 (563) alignment 
Range on Protein: 1074-1233
Range on HMM: 1-160/563.0
VSISDLGTHVASYHSDNNTAFNQQYQEL---YTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMELCErEYINATYIDGYSSANKFIAAQGP
| ....  |||| |.|... |......|    . .||...    ..||  ||  || .||.  . |.. |...    .|||| |||||  ...|||.|||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

MKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPD
.|.|. ||||.||...   |||.|||.| .. ||..|||.   |||..| ..|||..|.||  
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlal
0040438 (Phosphotyrosine protein) phosphatases II 1081-1239 1.4e-42 141.5 In-house 7-161 (317) alignment 
Range on Protein: 1081-1239
Range on HMM: 7-161/317.0
THVASYHSDNNTAFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNmeLCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWR
 ..  ..  ..||. .....|..    ...|.  ..||..||...| |||   ..|.  ..    .  |||| |.||..  .||||.|||...|. ||||
lalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

LIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSI
..|...  .|||.|.|.|  . ||.||||.   |. ..|.|.|||..|..|.....| .
mvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtl
subfamily_PTPRK_pd Subfamily PTPRK 1239-1425 4.9e-42 138.8 In-house 79-273 (314) alignment 
Range on Protein: 1239-1425
Range on HMM: 79-273/314.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG-EED---CCYPYWTGP-KTHDDFVVEITNEIKSNGYMERMFKVSF----DKESRNVLQL
| .|.  .|||..| |...||.|||... |.. ..||||    |     |. ||    ....|. ||. .    . .. |.|.|.      .| | | |.
idsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqf

QVTDWPQDGVVREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
| . ||. .|  . ...|...  | . |.. . |..|||||    |.|... ..| |.  . |||||||.. |..| .|.  | | |||. |||||
qflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
0037934 (Phosphotyrosine protein) phosphatases II 1246-1428 6.2e-42 139.2 In-house 45-241 (243) alignment 
Range on Protein: 1246-1428
Range on HMM: 45-241/243.0
RaFIIAQSPMENTVRD----FWKMIVDYKVSAIVMLCGEE----DCCYPYWTGPKTHDDFVVEITNEIKSNGYMERMFKVSF---DKESRNVLQLQVTDW
| .|. | |...|| |    ||.|. ......||||. ..      |..|| |..|..||.|....|   ..|. |.....    |...|.| ... . |
r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpw

PQDGVVREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGvVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVID
|  ||  .|  .|. .|.|.  ...        .||||.||||  |.|.|...   . |...   | ||.... | .|. .|| ||.|..||  .|... 
pdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall

MY
..
el
0050432 (Phosphotyrosine protein) phosphatases II 1073-1239 1e-41 138.7 In-house 23-186 (308) alignment 
Range on Protein: 1073-1239
Range on HMM: 23-186/308.0
SVSISDLGTHVASYHSDNNTAFNQQYQELYTGEDLPT-TVGFSEQNKPFNRFKNIAPYDEHMIVLqkkpnmElCEREYINATYIDGY--SSANKFIAAQG
|  .| |  . . .. .... ......||.   .|.. .|.  ..||..||.|.| |||   ..|      .  .  |||| |.|||   . .||||.||
slklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqg

PMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRA-ESEEFGPFSVTLVDEQVLPDFVIRSI
|...|. ||||..|...   |||.|.| |  . ||.||||.    .|.|.|.|.|||..|.||.|...| .
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtl
0043336 (Phosphotyrosine protein) phosphatases II 1074-1239 2.1e-41 137.6 In-house 2-162 (278) alignment 
Range on Protein: 1074-1239
Range on HMM: 2-162/278.0
VSISDLGTHVASYHSDNNTAFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMELceREYINATYIDGYSSANKFIAAQGPMKK
.|..||  ... .. ...|.. ....||..    ..... ...||..||.|.| ||| ....|.  .. .     |||| |.|||.  .||||.|||...
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpe

TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPngrAESEEFGPFSVTLVDEQVLPDFVIRSI
|. ||||..|...  .|||.|.|.|  . || ||||    .|...|.|.|||..|..|.|...| .
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1074-1239 3.5e-41 136.3 In-house 2-164 (318) alignment 
Range on Protein: 1074-1239
Range on HMM: 2-164/318.0
VSISDLGTHVASYHSDNNTAFNQQYQELYTGEDLPTTV-GFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPMK
.|..|| .||.  ... .. ....|..|   |. .|..   .. ||  ||. || .||.  . ||.. . |  . .|||| ||||| . ...||||.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegee..gsDyinanyidGyrrkkayiaaqaPlp

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSI
.|. ||||..|. .   |||.|...| .| |...|||.   .|...|   |.| .|  | |.|.|..
etieDfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlref
0039614 (Phosphotyrosine protein) phosphatases II 1064-1239 4.4e-41 136.7 In-house 4-174 (297) alignment 
Range on Protein: 1064-1239
Range on HMM: 4-174/297.0
FDPRIPNTCSVSISDLGTHVASYHSDNNTAFNQQYQELYTGEDlPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMELcEREYINATYIDGYSS-AN
. . . .......| |  ..  .. ...| . ....||.   . ..... ...||..||.|.| ||| ....|. .... | .  |||| |.|||.   .
lrdallesipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltr

KFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNGRAeseEFGPFSVTLVDEQVLPDFVIRSI
||||.|||...|. ||||..|...  .|||.|.|.|  . ||.||||.      ..|.|.|||.....|.....| .
kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1239-1426 6.9e-41 135.2 In-house 85-277 (315) alignment 
Range on Protein: 1239-1426
Range on HMM: 85-277/315.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC----GEEDCCYPYWTGPK-THDDFVVEITNEIKSNGYMERMFKVSFDKESRNVLQLQVTD
| ||  || .| ||.|  ..|.|||... ..... ||||     ||.  .  ||   | ..  . |   .| . . |  | . | |... |.|.||..| 
idGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhyts

WPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI-D
||. || .   .....|  |   ...   |..|||||. | |.| .....  |.| .|| ..||... . ||. . ..| ..|||  |||.. .
wpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
0036941 (Phosphotyrosine protein) phosphatases II 1085-1239 1.7e-40 134.6 In-house 6-157 (297) alignment 
Range on Protein: 1085-1239
Range on HMM: 6-157/297.0
SYHSDNNTAFNQQYQELYTGEDLPT-TVGFSEQNKPFNRFKNIAPYDEHMIVLqkkPNmelCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIW
. ...... . ....||.    |.. .|. ...|.. ||.|.| |||  ...|   ..    .  |||| |.|||.  .||||.|||...|. ||||..|
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd...egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

QEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQV--LPDFVIRSI
...  .|||.|.| |  . ||.||||.   || ..|.|.|||....|  |.|...| .
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtl
0045450 (Phosphotyrosine protein) phosphatases II 1067-1239 1.9e-40 134.9 In-house 2-183 (307) alignment 
Range on Protein: 1067-1239
Range on HMM: 2-183/307.0
RIPNTCSVSISDLGTHVASYHSDNNTAFNQQYQELYTGEDL---PTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMeLCEREYINATYI--------
..|  . ... .|  .|.  . |..| . .....|.  ..    ..... ...||..||.|.| ||| . ..|.  ... | .  ||||.|.        
dlplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvplllll

DGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGrAESEEFGPFSVTLVDEQVLPDFVIRSI
||| . .||||.|||...|. ||||..|...   |||.|.|.| .. || ||||.   |. ..|.| |||..|..|.....| .
dgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtl
0046845 (Phosphotyrosine protein) phosphatases II 1095-1241 2.7e-40 134.0 In-house 3-155 (284) alignment 
Range on Protein: 1095-1241
Range on HMM: 3-155/284.0
NQQYQELYTGEDL---PTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNmELCEREYINATYIDGY-----SSANKFIAAQGPMKKTLVDFWRLIWQEK
 ....||.        ...|.  ..|.  ||.|.| |||   ..|.  .. .| . .|||| |.|||      . .||||.|||...|. ||||..|...
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

PVSIVMVTNLKEGTKSKCEQYWPNGrAESEEFGPFSVTLVDEQVLPDFVIRSITG
   |||.|.| |  . ||.||||.   |. ..|.|.|||..|.| .|...| .. 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtlel
0047943 (Phosphotyrosine protein) phosphatases II 1088-1240 8.1e-40 132.4 In-house 8-156 (273) alignment 
Range on Protein: 1088-1240
Range on HMM: 8-156/273.0
SDNNTAFNQQYQELYTGEDLPT-TVGFSEQNKPFNRFKNIAPYDEHMIVLqkkpnmELCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEK
....| . .....|.   .| | .|.  ..|| .||.|.| |||  ...|      .  .  |||| |.||| . .||||.|||...|. ||||..|...
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

PVSIVMVTNLKEGTKSKCEQYWPNGRAE-SEEFGPFSVTLVDEQVLPDFVIRSIT
   |||.|.| |  . ||.||||.   | |...|.|.|||..|.. .|...| ..
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1242-1425 1e-39 131.1 In-house 71-262 (283) alignment 
Range on Protein: 1242-1425
Range on HMM: 71-262/283.0
YREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC----GEEDCCYPYWT--GPKTHDDFVVEITNEIKSNGYMERMFKVSFDKESRNVL---QLQVT
|.... .||||||...||.|||||. | |..|||||     ...  |  ||   | . . .| | . .|  || .. . . .  .  ... |     || 
ykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvi

DWpqdgVVREPRTVLQV---IDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
||    .  .. ...     .. ||  |..   ||.||||| .. |..|....|  ... ..| |||||.| | .|  ...|| ||.||  .....
dW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1074-1239 1.3e-39 131.1 In-house 5-166 (319) alignment 
Range on Protein: 1074-1239
Range on HMM: 5-166/319.0
VSISDLGTHVASYHSDNNTAFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPMKK
. . .| ...  ..|  .| .......| ....  ..    |.||. ||..|| .||   .||.. ...|  . .||||..||||   .||||.|.|...
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgve..gsdyinasfidgyqerekfiatqaPlen

TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSI
|. ||||..|.|.   .||.|.|.|  | |...|||.  .. ||.| . ||| .|. | |..|| .
tiedfWrmvWeeessivvmltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirkl
subfamily_PTPN12_pd Subfamily PTPN12 1239-1430 3.4e-39 129.5 In-house 76-278 (290) alignment 
Range on Protein: 1239-1430
Range on HMM: 76-278/290.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEE----DCCYPYWTGPK----THDDFVVEITNE-IKSNGYMERMFKVSFDKESRNVLQL
| |  .| ..| ||.|. .|. |||.|| ...|. .||.| |       |  ||.  .    ....| |. ..|   ..... |..|| ..||||.| |.
ikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqf

QVTDWPQDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
. |.||  || . . ..|..|..| ..|.     |.|||||  | | |. ... .  |. ||| .   .|||..   .|. .. .| | |||. .|  . 
hYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykava

MYLQ
 ..|
elvq
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1089-1240 5.6e-39 128.7 In-house 6-151 (283) alignment 
Range on Protein: 1089-1240
Range on HMM: 6-151/283.0
DNNTAFNQQYQELyTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNmelcerEYINATYID---GYSSANKFIAAQGPMKKTLVDFWRLIWQE
.|| .| .....| .  ||....  ...||..||...| |.| ... |. ...      .||||..|     |   .|.|.||.|...| ||||.....|
nnnklfrevlkrl.svpdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

KPVSIVMVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSIT
| ..|||.|.|.|. . || ||||.    ||..|.| ||| .|     |.|. ..
kitaivmltklqedlrikCsqyWPk..rGsedyGeftvtlrkettsnsfiikell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1241-1432 8.1e-39 128.5 In-house 89-287 (297) alignment 
Range on Protein: 1241-1432
Range on HMM: 89-287/297.0
GYREkrAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEE---DCCYPYWT--GPKTHDDFVVEITNEIKSNGYMERMFKVSFDK--ESRNVLQLQVTD
|...   .|  | ||..|| |||.|..|..||.||||  ..   . |  ||.  | .|  | .|...   . .|...| ..|. .|    | | | | ..
gnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfve

WPQDGVVR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
||.. | |  . ...|..|..| .  ..   ||..|||.  | | ||....   . . | |  ||.|.. | .|...|  | | |||. .| ..  .|  
WPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls

N
.
e
subfamily_Ptp69D_pd Subfamily Ptp69D 1073-1239 2.4e-38 127.0 In-house 3-166 (307) alignment 
Range on Protein: 1073-1239
Range on HMM: 3-166/307.0
SVSISDLGTHVASYHSDNNTAFNQQYQELY-TGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPM
...| || . . | . | .  . . |..|  .  |. |.|.  . |.  ||...| ..|.. ..|.| .  |  . .|||| .| ||   .||||||.|.
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPv

KKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraESEEFGPFSVTLVDEQVLPDFVIRSI
  |. ||||.|.. .   |||..||.| .. ||..|||.   .  ..|   |.||.|.  .|..||..
eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiRel
DSPc_SM00195 1094-1239 2.5e-38 127.3 In-house 2-147 (263) alignment 
Range on Protein: 1094-1239
Range on HMM: 2-147/263.0
FNQQYQELYTGE-DLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMelCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVM
.......| . . . .|| .  ..||  ||.||| |||.  . |.|...    . .|||| ||.|... .|.||.|||...|. ||||..|.||   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLP-DFVIRSI
.|. .|  | ||..|||.   ..|.|| .||.||...  . ....| .
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtl
PTPc_SM00194 1094-1239 2.5e-38 127.3 In-house 2-147 (263) alignment 
Range on Protein: 1094-1239
Range on HMM: 2-147/263.0
FNQQYQELYTGE-DLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMelCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVM
.......| . . . .|| .  ..||  ||.||| |||.  . |.|...    . .|||| ||.|... .|.||.|||...|. ||||..|.||   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLP-DFVIRSI
.|. .|  | ||..|||.   ..|.|| .||.||...  . ....| .
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtl
subfamily_PTPRK_pd Subfamily PTPRK 1074-1238 3.3e-38 126.3 In-house 4-159 (314) alignment 
Range on Protein: 1074-1238
Range on HMM: 4-159/314.0
VSISDLGTHVASYHSDNNTAFNQQYQELYTGedlpTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMelCEREYINATYIDGYSSANKFIAAQGPMKK
. . ||  ..|  .  ..  |...|. |. |      .   ..|.  ||...| .|| ....|.   .    . .||||..||.|  ...||..|||...
irvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgd..pssdyinaalidsykrpaafivtqgPlqe

TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgraESEEFGPFSVTLVDEQVLPDFVIRS
|. |||||...|.  ||||.|.|.| .. || .|||.   ..| .|.. |.||. ..| ..|.| 
tvkdfWrlvydencasivmltelvevgrvkClkyWPe...dtevygdikvelvetellaelvvri
subfamily_PTPRA_pd Subfamily PTPRA 1074-1239 4e-38 126.1 In-house 14-176 (330) alignment 
Range on Protein: 1074-1239
Range on HMM: 14-176/330.0
VSISDLGTHVASYHSDNNTAFNQQYQELYTGEDLPT-TVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPMK
. . .|   .    .|.|  | .... | .|.   |  .   |.||  ||. || |||   ..|..|  .|  | .||||..||||   .|||||||| .
lpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaqGPke

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaeSEEFGPFSVTLVDEQVLPDFVIRSI
.|. ||||.||. |  .|||.|.|||  ..||.||||.    .  .|   |.. ||.|| |. .| .
etvedfwrmiweqksativmltelkerkeekcaqywPdeG..lvtyGnirvevedetvlvdytvrkf
subfamily_CG7180_pd Subfamily CG7180 1239-1429 5.1e-38 125.4 In-house 78-290 (296) alignment 
Range on Protein: 1239-1429
Range on HMM: 78-290/296.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC---CYPYWTGP--KTHDDFVVEITNEIKSNGYMERMFKVSFD------------K
. ..  |...|. . |...|| .||... | ..||.|.|. . |    .  ||     . . ...|||..| .      |.||.                
vdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvka

ESRNVLQLQVTDWPQ-DGVVREPRTVLQVIDDVIHRQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLE
| | |...|.| |.  | |     ......  |   ..|.      |||||..|| .||||||... . ||. . |. ||||.  | .|||.|. | . |
etRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenve

QYTSIYDVIDMYL
.|  ||||.  ..
eYkyiYdvlleav
subfamily_PTPN6_pd Subfamily PTPN6 1245-1432 6.6e-38 125.4 In-house 97-300 (306) alignment 
Range on Protein: 1245-1432
Range on HMM: 97-300/306.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGPKTHDDF---VVEITNEIKSNGYMERMFKVS---FDKESRNVLQLQVTDW
....| .|  .|.|| |||.|... .   |||.  | .     |..||   ......    |. ..| . . |. | ..||   ..||.|.| |.. ..|
dksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksW

PQDGVVREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
|. || ..| .||. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | | .||  .| .| .|
PdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

LQMN
.. .
ietk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1239-1431 9e-38 124.9 In-house 65-270 (274) alignment 
Range on Protein: 1239-1431
Range on HMM: 65-270/274.0
ITGYR-EKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG--EE--DCCYPYWTGPK------THDDFVVEITNEIKSNGYMERMFKVSFDKESRNVL
| ||. |..|.. .| |. ||| |||.||   .|. ||||    |.  . |  |.   .      ...|. ..... .. |.|  | . ..  ...|.| 
ikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvk

QLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
    ||||   . ....|.|.....| . ...     .|||||||  . | |.. ..||.. | ..|.||||....  .|  . | | | |||  |. ..
hywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihral

DMYLQM
 .||. 
clylkr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1239-1424 1.1e-37 125.1 In-house 97-286 (319) alignment 
Range on Protein: 1239-1424
Range on HMM: 97-286/319.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgeEDCCYPYWT--GPKTHDDFVVEITNEIKSNGYMERMFKVSF---DKESRNVLQLQVTD
.|||. |  .| || |..||. |||.|| .|..|.||.|   .| |  ||   . .... | |...   ... |. | ...|     |. |.. |     
vtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflG

WPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
wpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1083-1238 1.4e-37 124.6 In-house 18-173 (298) alignment 
Range on Protein: 1083-1238
Range on HMM: 18-173/298.0
VASYHSDNNTAFNQQYQELYTGED----LPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPMKKTLVDF
.|  .. . | .....|.| ....      ..|. ...||  ||. .| ..|   .||.|. . |  | .||||.....|.  | |||.|.|...|..||
aavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedade..esdYiNAsflhaykgrnafiatqaPltetvedF

WRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRS
||....|.  .|||.|||.|  | |...|||.   ..|..| ..|.|  ...  |...| 
WrmvteedigtiVmltnleeldktkyhkywPd..egketygeitvsllskeefadlivrk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1239-1424 2.2e-37 124.1 In-house 61-250 (284) alignment 
Range on Protein: 1239-1424
Range on HMM: 61-250/284.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgeEDCCYPYWT--GPKTHDDFVVEITNEIKSNGYMERMFKVSF---DKESRNVLQLQVTD
||||. |  .| .| |..||. |||.|| .|..|.||.|   .| |  ||   . .... | |...   .|. |. | ...|     |. |.. |     
itGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflg

WPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
wpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_PTPRG_pd Subfamily PTPRG 1239-1426 4.5e-37 122.5 In-house 84-284 (563) alignment 
Range on Protein: 1239-1426
Range on HMM: 84-284/563.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG----EEDCCYPYW--TGPKTHDDFVVEITNEIKSNGYMERMFKVSF------DK--ESR
| ||. ..|||..| |...|. |||.|| . .|. |||.      .   |  ||   ...| . . | ...| .   | .| ...        ..  . .
idGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdtek

NVLQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
.| | . |.||. ||   .  ||. .     . .|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |||. ..|.
lvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhda

ID
. 
ll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1089-1241 6.5e-37 121.8 In-house 15-165 (515) alignment 
Range on Protein: 1089-1241
Range on HMM: 15-165/515.0
DNNTAFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMelCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPV
 . | | .....|   .  | ||   | | . ||.||| |||   . |.   .    . .|.||.|| .. . . .||.||| | .. |||||..||.. 
rhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindn..PhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvt

SIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITG
 |.|||.|||| |.|| .|||.  ..| .|| ..| ||  .   . ..| .| 
tiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1091-1239 8.5e-37 121.7 In-house 18-164 (315) alignment 
Range on Protein: 1091-1239
Range on HMM: 18-164/315.0
NTAFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMelCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSI
 . |......|   .  ...|.  ..| . ||.||| |.|.  ..|.   .    ...||||.|| .. . . .||.||| | .. ||||...|||. .|
talfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevidds..PdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtti

VMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSI
||||...|| | || ||||. .|.| ||| ..|.|.. .   | |.| .
vmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl
subfamily_PTPRB_pd Subfamily PTPRB 1239-1430 1.1e-36 121.4 In-house 87-286 (293) alignment 
Range on Protein: 1239-1430
Range on HMM: 87-286/293.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC--GE--EDCCYPYWT---GPKTHDDFVVEITNEIKSNGYMERMFKVSFDKESRNVLQLQV
| ||. .| || .| |. .|| |||.|. . |.|.||||    |     |  ||     | .. |  |....| . . .. | .|.. .||.|.| |.. 
ipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhf

TDWPQDGVVREPRTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
| ||. ||  ...|.|. .  | ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .|.
tsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN12_pd Subfamily PTPN12 1097-1240 1.7e-36 120.6 In-house 20-162 (290) alignment 
Range on Protein: 1097-1240
Range on HMM: 20-162/290.0
QYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNL
. ... . .  .|..| .|.|.  ||.|.| |||.  ..|.|. . |  . .|||| .| | ..  ..||||||. ||| ||||.||. .   .||. ..
lsekykaekvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCre

KEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLP-DFVIRSIT
 |  | |||.|||.   |. |||.|.||| .|. .  ||.||...
velgkkkCerYWpeegeeelefgefevtleeekavdddflirtLk
0045098 (Phosphotyrosine protein) phosphatases II 1108-1240 2.4e-36 120.9 In-house 24-140 (278) alignment 
Range on Protein: 1108-1240
Range on HMM: 24-140/278.0
PTTVGFSEQNKPFNRFKNIAPYDEHMIVlqkkpnmelcerEYINATYIDGYssANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQY
  |..  . |...||.|.| |||  ...            .||||.|||||   .||||.|||...|. ||||..|...  .|||.|.|.|... ||.||
eitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPNgrAESEEFGPFSVTLVDEQVLPDFVIRSIT
||.   .|...|.|.|||..|.||.|...| ..
wpe..ggsltygdftvtllseevlddytlrtll
subfamily_PTPN6_pd Subfamily PTPN6 1089-1240 3e-36 120.0 In-house 23-175 (306) alignment 
Range on Protein: 1089-1240
Range on HMM: 23-175/306.0
DNNTAFNQQYQELYT---GEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQkkpNMELCEREYINATYIDG--YSSANKFIAAQGPMKKTLVDFWRLIW
 ... |.....|| .    . |  . |   .||  ||.||| |.|.  ..|.   . .. . .|||| ||..   .| ...||.|| ...|. ||||..|
lekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

QEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEeFGPFSVTLVDEQVLPDFVIRSIT
||.   |||.|.  | .|.|| .|||.  ...| .|  ||| |.|. | |...|...
qensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRels
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1239-1426 3.3e-36 119.8 In-house 83-276 (288) alignment 
Range on Protein: 1239-1426
Range on HMM: 83-276/288.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTG---PKTHDDFVVEITNEIKSNGYMERMFKVSFDKESRNVLQLQV
| |...|...| .|.|. .|| |||... ..|.| |||| .    ..  |  ||     || . .. |..... . . ...| . .  .|. ... |.| 
idgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqy

TDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
. ||..|| .  . .|.... |   .|.   ||..||||. | |.|.. ..   ... ..| ..||. . . .|....  | ||.||  ||.|. 
laWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
0040439 (Phosphotyrosine protein) phosphatases II 1109-1240 9.2e-36 119.1 In-house 3-130 (249) alignment 
Range on Protein: 1109-1240
Range on HMM: 3-130/249.0
TTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMELCEreYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
..|.  . ||. ||...| ||| ....|.  |...|.   |||| ||||| . ..|||.|||...|. ||||..|...  .|||.|.|.|  . ||.|||
ysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PNgrAESEEFGPFSVTLVDEQVLPDFVIRSIT
|.   .| |.| |.|||....|..|...| ..
pl..ggsleygdftvtllsvevkddytvrtle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1239-1435 1.5e-35 117.5 In-house 80-284 (315) alignment 
Range on Protein: 1239-1435
Range on HMM: 80-284/315.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG--EEDC--CYPYWTGPKT----HDDFVVEITNEIKSNGYMERMFKVSFDKESRNVLQLQ
| .. . .|.| .| | . .| |||.|....||..|||.    |.|   |  ||   |.       . ||. .     . . | . .   .|||.| | |
iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfq

VTDWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
 |.||. || ..  ..|..| .|    ..    ...||||  | |.|| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||..  .|.
ftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

-MNSII
  |..|
wrntli
Y_phosphatase Protein-tyrosine phosphatase 1117-1238 2.1e-35 117.6 Pfam-A 1-120 (235) alignment 
Range on Protein: 1117-1238
Range on HMM: 1-120/235.0
NKPFNRFKNIAPYDEHMIVLQKKPNMELcereYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESE
||  ||.|.| |||. .. |..... .     |||| |..||.. .||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||. . ||.
nkkknRykdilpydktrvklkgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EFGPFSVTLV-DEQ-VLPDFVIRS
..| ..|.|. .|.    ....| 
tygdikvelkekekedekeytlrk
Y_phosphatase Protein-tyrosine phosphatase 1117-1238 2.1e-35 117.6 In-house 1-120 (235) alignment 
Range on Protein: 1117-1238
Range on HMM: 1-120/235.0
NKPFNRFKNIAPYDEHMIVLQKKPNMELcereYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESE
||  ||.|.| |||. .. |..... .     |||| |..||.. .||||.|||.|.|. ||||..||||  .|||.|.|.|  . ||.||||. . ||.
nkkknRykdilpydktrvklkgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EFGPFSVTLV-DEQ-VLPDFVIRS
..| ..|.|. .|.    ....| 
tygdikvelkekekedekeytlrk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1080-1238 5.2e-35 115.9 In-house 3-159 (281) alignment 
Range on Protein: 1080-1238
Range on HMM: 3-159/281.0
GTHVASYHSDNNTAFNQQYQELYT-GEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPMKKTLVDF
 .|... ....|. | ..|..|.  | | ..|  ....|.  ||..||  ||   ...... . .  . .|||| ...||.. ...||.|||. ..||.|
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvpgykgekeyiatqgPvPaslvaf

WRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAeSEEFGPFSVTLVDEQVLPDFVIRS
|...|..|   |||||.  |. | || .|||.... . ..| . |. . |.  . .. | 
WqmvweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1239-1435 7.9e-35 114.9 In-house 79-283 (515) alignment 
Range on Protein: 1239-1435
Range on HMM: 79-283/515.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEE----DCCYPYWTG-PKT---HDDFVVEITNEIKSNGYMERMFKVSFDKESRNVLQLQ
| ..   .|.| .| | . .| |||.......|..|.|.   .      |  ||   |        . ||.       | . | ..|  ...|| | | .
ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfh

VTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
 |.||. || .. ...|..| .|   ....   |...|||  | | ||..|.   . . |   .||||.. . .|. .|  | | |||. ||...  .| 
fteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

-MNSII
  |..|
wrntli
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1074-1239 1e-34 114.9 In-house 6-166 (315) alignment 
Range on Protein: 1074-1239
Range on HMM: 6-166/315.0
VSISDLGTHVASYHSDNNTAFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPMKK
. . .| |.||  ..  .  |.|.|. .  |.  |  |    .||  ||. || .||.  . |    | .  . .|.||..||||.  ...||||||   
ipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendp..hsdyvnanfidGynkkrryiaaqgpnva

TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGraeSEEFGPFSVTLVDEQVLPDFVIRSI
.. |||||...|.   |||.||| || |.|.|.|||.       .|...||...|.|  .. .|..
svkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1239-1430 1.3e-34 114.6 In-house 77-277 (281) alignment 
Range on Protein: 1239-1430
Range on HMM: 77-277/281.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGPK---THDDFVVEITNEIKSNGYMERMFKV-SFDKESRNVLQLQ
. ||......|..|.|. ... .||.|....|||||||.  | .     |. ||  ..   .  |..|. |.| ... |.|| ||.   . |.|.| ||.
vpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqla

VTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 | ||. ||  ... .|.  ..| . ..|    |.|.|||  | |.|.| ..   .....||   .|| .| . .|...   | |. ||. .| ..  .|
ytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

Q
.
d
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1088-1239 6.2e-34 112.7 In-house 30-173 (319) alignment 
Range on Protein: 1088-1239
Range on HMM: 30-173/319.0
SDNNTAFNQQYQELYTGEDLPTTVGFS--EQNKPFNRFKNIAPYDEHMIVLQKKPNMELCerEYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQE
 |. | .. ... .       ..  |.  .|||  ||. || ..|. .. |..   .|    .||||....|| . .|.||||||.. || ||||.||. 
dddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefs..dyinasfvtGyqrkdkyiaaqGPldntladfWrmiwey

KPVSIVMVTnlkegtKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLpdFVIRSI
.  .||..|      | || ||||.   . || .  .|..|.|     .|.|.|
ncstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdi
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1243-1431 9.6e-34 111.6 In-house 61-266 (270) alignment 
Range on Protein: 1243-1431
Range on HMM: 61-266/270.0
REKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTGPKTH-----D-DFVVEITNEIKSNGYMERMFKVSFDKESRNVLQLQVT
 ||...| |..|...|...||.||.. ||.||||. |      . |  ||.  . .     | .  |  ..| |..||. .  ..  . |.|...  . .
gekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyn

DWPQDGVVREPR------TVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.||..||.||.        .|... .|  .....  ..|..||||. | |.|.   . |...  . .. ||| .. ...|. ..  | . |||. .| ..
tWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykav

DMYLQM
 .| ..
veyaer
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1111-1239 1.4e-33 111.1 In-house 3-126 (250) alignment 
Range on Protein: 1111-1239
Range on HMM: 3-126/250.0
VGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMELCerEYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSkCEQYWPN
|.   |||  ||. .| ..|.  .||.|.   . .  .||||....||.  . |||.|||...|..||||....||  .|||.|||||  |  ..|||| 
vakkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

GraESEEFGPFSVTLVDEQVLPDFVIRSI
   ..|..|   |.| ....  |...| .
e..kaekyGdvtvsllskeefadytkrkl
subfamily_PTPN9_pd Subfamily PTPN9 1114-1239 3.5e-33 109.9 In-house 39-162 (297) alignment 
Range on Protein: 1114-1239
Range on HMM: 39-162/297.0
SEQNKPFNRFKNIAPYDEHMIVLQKKPNMELCerEYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRA
.  |   ||....  |||  .||.|... |    .|||| ..|||   . |||.|||.|||  ||||..|... . |||.| . |  . || ||||... 
lranleknrytdvlcydetrvvlakvdedeas..dyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee

ESEEFGPFSVTLVDEQVLPDFVIRSI
.|.||| .||. |. ..  |...|..
ssaefgdlsvsnveveeeedykvrvl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1115-1239 5.9e-33 109.6 In-house 23-137 (284) alignment 
Range on Protein: 1115-1239
Range on HMM: 23-137/284.0
EQNKPFNRFKNIAPYDEHMIVLQKKPNMELCerEYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNGRAE
.|||  ||. .| ..|. .. |..   .|    .||||..| || . .|.||.|||.. || ||||.||. .  .||..|      | || ||||.   .
dqnkdknrighilafdknvvklerliGeefs..dyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

SEEFGPFSVTLVDEQVLpdFVIRSI
 || .  .|..|.|     .|.|.|
keerfkvkvdsveesee..yvvrdi
0042113 (Phosphotyrosine protein) phosphatases II 1112-1239 1.4e-32 108.5 In-house 4-127 (245) alignment 
Range on Protein: 1112-1239
Range on HMM: 4-127/245.0
GFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMELCEreYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNg
.  . ||..||...| |||  ...|.  .. . .   |||| |.|||   .||||.|||...|. ||||..|...  .|||.|.. |  . ||.||||. 
allpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

rAESEEFGPFSVTLVDEQVLPDFVIRSI
  || ..| |.|||..|..|.|...| .
.gesltygdftvtllseehlddytvrtl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1241-1432 2.9e-32 107.1 In-house 86-292 (325) alignment 
Range on Protein: 1241-1432
Range on HMM: 86-292/325.0
GYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVML---CGEEDCCYPYWTGP----KTHDDFVVEITNEIKSNGYMERMFKVSFDKE--SRNVLQLQV
 ...|  |. ||.|. .|. |.|....|.. | .|.|    ...| |  ||       ||   . |..    .   |. |...|   |.  .| | |.|.
ddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfql

TDWPQDGVVREPRTVLQVIDDVIHRQQKI-----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI-
  |.. || . | |.. ... | . ....     . .|..||||. | |.||. |.   |..   |  ||.|.. | .|. .|  | | .||. ||. . 
qswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv

DMYLQMN
..|.  |
eaymsgn
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1073-1239 3.1e-32 107.0 In-house 4-167 (325) alignment 
Range on Protein: 1073-1239
Range on HMM: 4-167/325.0
SVSISDLGTHVASYHSDNNTAFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPnmELCEREYINATYIDGYSSANKFIAAQGPMK
|... .|  ||   ..... .| .... | . .    .|    .||  |||||. ..|.  .||. |   .  . .||||.|.  .   . |.||| |. 
siavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkk..ddpssdyinasylrddkkkdvflaaqaPlt

KTLVDFWRLI--WQekpVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSI
.|. |.|||.  |.    |.|.|.|  .. | .| .|||.  ..| .||.. | |.  . . |.| | .
atindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvl
subfamily_PTPN3_pd Subfamily PTPN3 1095-1240 1.1e-31 104.8 In-house 18-161 (280) alignment 
Range on Protein: 1095-1240
Range on HMM: 18-161/280.0
NQQYQELYTG-EDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNmELCEREYINATyIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMV
 .|...||   ..| ...    .| . ||...|.|||.  . |.. .. .  . .|.|   |.. .  |..||.|||..||  |||...|..|   |||.
laqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnme.ipstglvnryiatqGPlaktatdfWqmvweqksslivml

TNLKEGTKSKCEQYWPNgRAESEEFGPFSVTLVDEQVLPDFVIRSIT
|.| |  . || ||||.   .. |.| |||..  |.    .|.| ..
ttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelv
0051429 (Phosphotyrosine protein) phosphatases II 1239-1430 2e-31 105.1 In-house 12-226 (272) alignment 
Range on Protein: 1239-1430
Range on HMM: 12-226/272.0
ITGYRE---KRAFIIAQSPMENTVRDFWKMiVDYKVSAIVMLCGEE----DCCYPYWT--------------GPKTHDDFVVEITNEIKSNGYMERMFKV
. ||     ..... .. |...|..|||..  ......||.|..||    . |..||                . .. ...| .. |.  . |. |.. .
vggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrelll

S---FDKESRNVLQLQVTDWPQDGVVREPrtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD--------VFQVTKAVRR
.     .|.| |..|. |||| .|| .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||        .... . .|.
tlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelra

SKPGAVTTLEQYTSIYDVIDMYLQ
  |||| | |||  .|...  .| 
qrpgavqteeqylflyeallellr
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1200-1427 2.5e-31 103.7 In-house 21-257 (267) alignment 
Range on Protein: 1200-1427
Range on HMM: 21-257/267.0
TKSKCEQYWPNGRAESEEFG---PFSVTLVD-EQVLPDFVIRS-ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGE--ED--CCYPYW-T
|.|.. |....  .| . .    |.  | |   .   ...  | . ||. |.|||. | |..||. ||...| |.||. ||.|     ..    .|    
tsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmg

GPKTHDDFVVEITNEIKSNGYMERMFKVSFDKESR-NVLQLQVTDWPQDgvvREPRTVLQVIDDVI-HRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLE
  | ..|..|| . | . | |    ... | .||  ||       |  .    . .  |. .  .. . | . |. |.||.||| | ||| .  .   ||
qakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnin...tnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqle

QCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
. | |||.|.|.  . .|  ..| | |.|.|  |....  
raktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_PTPN23_pd Subfamily PTPN23 1247-1425 4.1e-31 102.9 In-house 84-276 (288) alignment 
Range on Protein: 1247-1425
Range on HMM: 84-276/288.0
AFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDCCYP----YWT----GPKTHDDFVVEITNEIKSNGYMERMFKVSFDKE--SRNVLQLQVTDWPQ
 ||..|.|...|. |||.|... |.| ||||  .|.   |    ||      .....|. | . .. ... ..||..|... ..   ..|  ||.| ||.
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpe

DGVVREPRTVLQVIDDVIH---RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||   | |.||..| | .    .|.    |.|||||  | |.||.. |   ...  | .|..|. || . .|. .   | . ||.   |...
lGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_PTPN9_pd Subfamily PTPN9 1240-1428 5.3e-31 102.7 In-house 79-289 (297) alignment 
Range on Protein: 1240-1428
Range on HMM: 79-289/297.0
TGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG--E--EDCCYPYWT-GPKT---HDDFVVEITNEIKSNGYMERMFKVS--FDKESRNVLQL
 ||..|.||| .| |...||.|||.|. . .|  |||     |     |  ||  . ..   . |. |.  .  ... |..|.....   ..|||.|   
dGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthf

QVTDWPQDGVVREPRTVLQVIDDVIHRQQ------------KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQ
|.. ||  || ..  ..|.|.. | ..|             .. | |.|||||  . |.| .... | |.. . .|.|||... | .|  .  .. | ||
qflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeq

YTSIYDVIDMY
|.  |  .  |
yefcylavley
0041856 (Phosphotyrosine protein) phosphatases II 1239-1432 1.3e-30 101.7 In-house 27-174 (182) alignment 
Range on Protein: 1239-1432
Range on HMM: 27-174/182.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgeedcCYPYWTgpkthddfvveitneiksngymermfkvsfDKESRNVLQLQVTDWPQDG
. |..  . ||..| |. .|| ||..|. ......||.|.     ...||                               ... |...|.. . || .|
ylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp..............................ellerlgiqylylpwpDhg

VVRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
|   ....|. |..|..      ||||.||||  |.|.|...   . ...    | |..... | ||. .||.|.|..||  ..... ..|. .
vpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1117-1239 1.8e-30 101.0 In-house 30-152 (274) alignment 
Range on Protein: 1117-1239
Range on HMM: 30-152/274.0
NKpfNRFKNIAPYDEHMIVLQKKPNMeLCEREYINATYIDGYSSANK-FIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAE-
.|  ||.|.| | ..  ..|... .    . .|||| || ||.  .| ..|.|||. .|. ||||.|.||.   |||.|.|||  ..||..|.|. .   
tk..nryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

-SEEFGPFSVTLVDEQVLPDFVIRSI
 ||..| .... ..     |. .|..
iserygdveikvekiverndysvrkl
subfamily_PTPN23_pd Subfamily PTPN23 1086-1239 2.8e-30 100.1 In-house 9-160 (288) alignment 
Range on Protein: 1086-1239
Range on HMM: 9-160/288.0
YHSDNNTAFNQQYQELYTGEDL---PTTVGFSEQNKPFNRFKNIAPYDEHMIVLQkkpnmeLCEREYINATYIDGYSS-ANKFIAAQGPMKKTLVDFWRL
   |..||......|| . .|     ...  .. .   ||...| |||.  ..|.        . .||||... . |. . .|||.|.|...|| |||..
kmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlm

IWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSI
....|   |||... .|  | |...|||. . |...||..|||| ... .. .| | .
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervl
0037934 (Phosphotyrosine protein) phosphatases II 1111-1242 2.9e-30 101.0 In-house 4-124 (243) alignment 
Range on Protein: 1111-1242
Range on HMM: 4-124/243.0
VGFSEQNKPFNRFKNIAPYDEHMIVLqkkpnmelCEREYINATYIDGYssaNKFIAAQGPMKKTLVD----FWRLIWQEKPVSIVMVTNLKEGTKSKCEQ
.. ...|.. ||...| |||  ...|            |||| .|...   ...|| |||...|. |    |||..|...  .|||.|.|.| .. ||.|
iallpenlsknrysdilpydhsrvkl........egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPngraESEEFGPFSVTLVDEQVLPDFVIRSITGY
|||    .....|.|.|||..|..|.|...| .. .
ywp....gevtygdftvtllseehlddytvrtllle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1238-1425 1.6e-29 97.6 In-house 83-275 (439) alignment 
Range on Protein: 1238-1425
Range on HMM: 83-275/439.0
SITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDCcYPYWTGPKT--HDDFVVEITNEIKSNGYMERMFKVSFD----KESRNVLQLQV
 | || ... .| .| | ..|. |||..... |.. ||||.   .  | ||   .   . | .| .  .|.   |. | |||  .    .  | |||.. 
yikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlves.ykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhy

TDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. ||.  |  .   ||. .  .   ..|   ||||||||  | |.|   .. | ||| |.|  ||.  . | .|. .   | .| ||  ||. .
iawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_PTPN3_pd Subfamily PTPN3 1246-1425 2.2e-29 97.3 In-house 84-271 (280) alignment 
Range on Protein: 1246-1425
Range on HMM: 84-271/280.0
RAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGE----EDCCYPYWTGPK---THDDFVVEITNEIKSNGYMERMFKVSFDK--ESRNVLQLQVTDWPQ
  .|..| |...|. |||.|. . |.| ||||          |. ||  ..   .. .| |....| ... |. | . ..  .  |.|..|||| ..||.
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpd

DGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||  ..  .|.... | .....    |||||||  . |.||.  . . |    |.  | . .. . .|  .   | | .||. . . |
hgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1103-1223 1.8e-28 94.3 In-house 6-127 (270) alignment 
Range on Protein: 1103-1223
Range on HMM: 6-127/270.0
TGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNmeLCEREYINATYIDGYSSA-NKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTK
 .|  ....    ..| .||...| |  .  ..|..  .    . .|||| |. |.... .|.|||.||.. || .|||.||.||  .|||.|.|.|  .
keetsesdlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgr

SKCEQYWPNGRAE--SEEFGPFSV
.|||.|||. . |  . |.|  .|
kkCerYWpaepkekvkledgkikv
subfamily_PTPN14_pd Subfamily PTPN14 1244-1430 2.7e-28 93.8 In-house 91-297 (300) alignment 
Range on Protein: 1244-1430
Range on HMM: 91-297/300.0
EKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGE----EDCCYPYWTGP------KTHDDFVVEITNEIKSNGYMERMFKVSF--DKESRNVLQLQV
..| .|.||.|.|.||.|||.|. . .|. ||||  |     . .. |.          ... | |      .|. .. . .|. .   || |.|. || 
kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy

TDWPQDGVVREPRTVLQVIDDV---IH-RQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
||||..|| ..... |. ...|    .  ....       ||.||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.
tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYk

VIDMYLQ
|.  ||.
vlikylk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1238-1425 2.9e-28 93.4 In-house 228-434 (440) alignment 
Range on Protein: 1238-1425
Range on HMM: 228-434/440.0
SITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED-CCYPYW---TGPKTHDDFVVEITNEIKSNGYMERMFKVSFDKESRNVLQLQVTD
 . ||  | ||| .| |.. || |||... ||..|.|.||   .|  |  ||   |   |   | |      . |    | ... . .|  .. |..|  
efegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqt

WP----QDGVVREPR---TVLQVIDDV----IHR---QQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQY
||     |||  . .   .|||..| .    | |   | . |   |..|||   .  |||.|.|   ||| . .| .||||  . .| |.|  | || .|
wptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdy

TSIYDVI
   | ..
llcykll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1116-1240 6.6e-28 92.5 In-house 2-122 (237) alignment 
Range on Protein: 1116-1240
Range on HMM: 2-122/237.0
QNKPFNRFKNIAPYDEHMIVLQKKPNMelceREYINATYIDGYSSA-NKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaE
.||  ||. ||  ||   .||.   .      .||||||..|.  . .|.||||||.. .  |||...||||   |||.| | || . || .|||.   .
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.q

SEEFGPFSVTLVDEQVLPDFVIRSIT
 . .| ..|.|  .. . |. .||..
paaygvltvslkkkeefsdytvrsll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1076-1239 1e-27 92.0 In-house 12-166 (297) alignment 
Range on Protein: 1076-1239
Range on HMM: 12-166/297.0
ISDLGTHVASyhSDNNTAFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMelCEREYINATYIDGYSSanKFIAAQGPMKKTL
.||. | |    . . . |..... | . .  |.||     | . .|.||| |||   . |.   .    . .|.|| .. |.    ..|. | ||| |.
lsdfatlvqk..nrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivndd..pdsDyvnasfvkgnkh..rlittqmPmkatv

VDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNGRAESeeFGPFSVTLVDEQVLPDFVIRSI
 |||.....|..  |||.....|..| || .||..    .  ||  ||.|   .    |. |..
adfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1246-1425 1.1e-27 91.8 In-house 45-235 (237) alignment 
Range on Protein: 1246-1425
Range on HMM: 45-235/237.0
RAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG----EEDCCYPYWT---GPKTHDDFVVEITNEIKSNGYMERMFKVSFD---KESRNVLQLQVTDWP
. .| || |.|..  |||.|. . | | |||| |    .|  |. ||     |...  . | .. . .   |  | . .|     || | . | | | ||
kkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswp

QDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. || ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  ...   .|  . | .||  |...|
drgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_PTPN13_pd Subfamily PTPN13 1245-1430 2.3e-27 90.9 In-house 76-270 (273) alignment 
Range on Protein: 1245-1430
Range on HMM: 76-270/273.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGPKTH-----DDFVVEITNEIKSNGYMERMFKVSF--DKESRNVLQLQVTD
.  .|..| |. .||.|||.|. . |.. |.|.  | .     |  ||   | .     . . ||  .  | .|.  | ..|.    .|||.| .|. ..
eyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvk

WPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
||  || ...  .||..  | . |.    ||.|||||  . |||.. .. . |.  . .  .|| .. . .|. . | | | .||  .| .|   |.
wPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
0043147 (Phosphotyrosine protein) phosphatases II 1239-1423 9.5e-27 89.2 In-house 13-155 (172) alignment 
Range on Protein: 1239-1423
Range on HMM: 13-155/172.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEedccypywtgpkthddfvveitneiksngymermfKVSFDKESRNVLQLQVTDWPQDG
. .|.  . ||. | |. ||. |||.|. ......||.|...                                    .  ....|...|.. . ||  |
ldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...................................lydpellerlgiqylylpwpDhg

VVrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|   .. .|.... . .....  ||||.||||  |.|.|. .   . |        . ..... . ||. .||||.. .||  .|.
vp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyy
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1239-1433 1.2e-26 88.2 In-house 73-281 (287) alignment 
Range on Protein: 1239-1433
Range on HMM: 73-281/287.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGE-ED---CCYPYWTGPKTH----DDFVVEITNEIKSNGYMERMFKVSfDKESRN---VL
...|... ||| ||.|.  ||||||..... ........  | |.    || ||  ..         || .  .||.  |  | ...  | |.|.   | 
vasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrli.dletrearvvk

QLQVTDWPQDGVVRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
||.. .||....        | ||.| . .  ...  . ||.|||..  . |||.. .. . ... .  | ||| .|   .|  . . | .  |.  .|.
qldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllye

VIDMYLQMNS
 .  | . | 
alvtyyktnp
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1118-1239 1.3e-26 88.1 In-house 39-157 (287) alignment 
Range on Protein: 1118-1239
Range on HMM: 39-157/287.0
KPFNRFKNIAPYDEHMIVLQKKPNMElceREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGrAESEE
   ||. .. |.|.  ..| .....     .|||| |. .|   ..|||||||.  |. ||||......  |....|   | .. || .|||.       
vkknryadvlPiddtrvllsaegelG...sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmr

FGPFSVTLVDEQVL-PDFVIRSI
 | .||.|.| ... |.. .|..
vGGysvvlldydikePeygvral
0036282 (Phosphotyrosine protein) phosphatases II 1240-1423 1.4e-26 88.7 In-house 11-164 (174) alignment 
Range on Protein: 1240-1423
Range on HMM: 11-164/174.0
TGYREKRAFIIAQSPMEntvrdFWKMIVDYKVSAIVMLCGEED----CCYPYWTGpkthddfvveitneiksngymermfkvSFDKESRNVLQLQVTDWP
 ...  . .|. | |..     ||.|. .......|||. |.      |. ||                               . ..|...|.. . ||
dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...........................lredlerlgiqylylpwp

QDGVVREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
 .||   .  .|.... | . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
Dhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_PTPN1_pd Subfamily PTPN1 1093-1239 3.1e-26 86.8 In-house 7-151 (290) alignment 
Range on Protein: 1093-1239
Range on HMM: 7-151/290.0
AFNQQYQELYT-GEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNmelcerEYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIV
 ... |...    .|.||..   ..|.. ||.... |||   |.|... |      .||||. ..      ..| .|||. .|   ||...|..|  ..|
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

MVTNLKEGTKSKCEQYWPNGRA-ESEEFG--PFSVTLVDEQVLPDFVIRSI
|. .. |  . || ||||.|   .. ..    ..|.|. |..   ...| .
mlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrll
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1117-1239 5.5e-26 86.2 In-house 8-126 (239) alignment 
Range on Protein: 1117-1239
Range on HMM: 8-126/239.0
NKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSA-NKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAes
||  ||. ||  ||   .||.|  |      .||||.|.  |  . . .||.|| .. .  ||||..|||. . |||.| | || | || ||||.  .  
nkaknryanivtydhsrvvleklsndp..hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

eEFGPFSVTLVDEQVLPDFVIRSI
 ..  . |||   .|. |..||..
.kycnlrvtlrktevfadyiirtf
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1117-1239 5.5e-26 86.2 In-house 7-125 (239) alignment 
Range on Protein: 1117-1239
Range on HMM: 7-125/239.0
NKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSA-NKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAes
||  ||. ||  ||   .||.|  |      .||||.|.  |  . . .||.|| .. .  ||||..|||. . |||.| | || | || ||||.  .  
nkaknryanivtydhsrvvleklsndp..hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

eEFGPFSVTLVDEQVLPDFVIRSI
 ..  . |||   .|. |..||..
.kycnlrvtlrktevfadyiirtf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1232-1434 8.9e-26 85.2 In-house 73-242 (392) alignment 
Range on Protein: 1232-1434
Range on HMM: 73-242/392.0
PDFVIRS-ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG--EEDccypywtgpkthddfvveitneiksngymermfkvsFDKESRNVLQ
 |..  | | ..  ..|.| .|.|   .. |||.|. . .|..|.|.    | |                                      .. | | |
sdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd....................................kgddartvaq

LQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV-IDM
 ..|.||...| .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | |||. ||   .. 
fhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled

YLQMNSI
 |  |..
llwrntl
subfamily_CG7180_pd Subfamily CG7180 1112-1239 2e-25 84.0 In-house 37-159 (296) alignment 
Range on Protein: 1112-1239
Range on HMM: 37-159/296.0
GFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNG
|  ..|.  ||  .. |||   .||.|    |  . .||||.|.|..   ...|  ..|.|.|. .||||...|.  ..|..|.  . .| .. .|||| 
glrkenreknrdvkvvPyDynRvvLekldGee..ksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

RaeSEEFGPFSVTLVDEQVLPDFVIRSI
    |..|.. | .| |. .....|| .
s..keqygeifveiveekqyanlkirtf
subfamily_PTPRN_pd Subfamily PTPRN 1086-1239 2.9e-25 83.6 In-house 20-176 (297) alignment 
Range on Protein: 1086-1239
Range on HMM: 20-176/297.0
Y---HSDNNTAFNQQYQEL--YTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYI-DGYSSANKFIAAQGPMKKTLVDFW
|   |  |.. ...... |  |  |.  ..|. .|.|   || |.. |||. .. |... . |  . .||||. | |    |  .||.|||. .|. |||
yledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasae..ksdyinasaildhdprapayiatqgplastvadfw

RLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRaeSEEFGPFSVTLVDEQVL-PDFVIRSI
...|..  | ||..|.|.|   ..|..|||.    || .. . | || | .   |...||.
qmvweqGvvvivnltrleeegvkqckrywpdeG..sevyhiyevhlvsehiwcddylvrsf
subfamily_PTPN13_pd Subfamily PTPN13 1108-1240 5.5e-25 83.2 In-house 28-156 (273) alignment 
Range on Protein: 1108-1240
Range on HMM: 28-156/273.0
PTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNmelcereYINATYIDGYSSANK--FIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCE
 ..|| ...||  ||..|. ||||  . |... .       ||||..|      ..  .||.|||. .|  |||...|. |   |.|||. ||. | ||.
tcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

QYWPNGRAESEEFGP-FSVTLVDEQVLPDFVIRSIT
.|||. . ..      . |.|.. | | .||.|...
rywPesknkklkvsnrlevellkvqkldgfvvrala
subfamily_PTPN14_pd Subfamily PTPN14 1109-1224 7.2e-25 82.6 In-house 41-157 (300) alignment 
Range on Protein: 1109-1224
Range on HMM: 41-157/300.0
TTVGFSEQNKPFNRFKNIAPYDEHMIVLQkkPNMELcEREYINATYIDGYSS--ANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQ
....  ..|.. ||||.. ||..  . |.  |. |  . .||||. |    .    ..|.||||...|. |||...|...   |||.|. .|. | |. .
lstaklpenaeknrfkdvlPyednrvels..ptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWPNG--RAESEEFGPFSVT
|.|.   .... ||| | ||
yfPkleskkktvefgkfkvt
0049260 (Phosphotyrosine protein) phosphatases II 1239-1423 8.6e-25 82.6 In-house 2-144 (152) alignment 
Range on Protein: 1239-1423
Range on HMM: 2-144/152.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED----CCYPYWtgpkthddfvveitneiksngymermfkvsfdkesrnvlQLQVTDW
| ||. ...||..| |..||. |||.|. ......||||. ...    .|. |.                                       | . . |
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.......................................qylhlpw

PQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
| .||   .  .|.... . .. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .|.
pDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1091-1210 1.6e-24 81.0 In-house 19-144 (392) alignment 
Range on Protein: 1091-1210
Range on HMM: 19-144/392.0
NTAFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPnmELCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSI
.. | .....|   .  |.||.  | |.. ||.||| |||.  ..|.     .  ...|.||.||... . . .||.|||   .| ||||...||.. .|
salffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid..dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvtti

VMVTNLKEGTKS----KCEQY----WPN
.|||.|||| |      . |.    ||.
amvtklkegdkgddartvaqfhftewPd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1081-1238 1.7e-24 81.1 In-house 9-160 (439) alignment 
Range on Protein: 1081-1238
Range on HMM: 9-160/439.0
THVASYHSDNNTAFNQQYQELYTGE-D--LPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMelCEREYINATYIDGYSSANKFIAAQGPMKKTLVD
 ||   . ...  |.. .... . . |    ...   | ... ||.|.....|   ..||. | .      |||| ||.||   . .||.||| |.|  |
ehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyyddklyiatqgpkkettdd

FWRLIWQEKPVSIVMVTNLKEGTKskceqYWPNGraESEEFGPFSVTLVDEQVLPDFVIRS
||||....| | |||.||| |  |     |||    .   .|  .|    .  ||..||| 
fwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnielpnyvirg
0046846 (Phosphotyrosine protein) phosphatases II 1247-1429 3.3e-24 81.0 In-house 24-173 (176) alignment 
Range on Protein: 1247-1429
Range on HMM: 24-173/176.0
AFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDC----CYPYWTGPK---ThddfvveitneiksngymermfkvsfdkesrnvlQLQVTDWPQDGV
..|. | |...|. ||..|. .....|.|.|. | .     |. ||   .                                      | ....||  ||
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..................................qylhlpwpDhgv

VREpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRRSKP-GAVTTLEQYTSIYDVIDMYL
    . .|.... .  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| |||  .|... ..|
pdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
PTPc_DSPc_SM00012 1326-1425 1.2e-23 78.7 In-house 2-103 (105) alignment 
Range on Protein: 1326-1425
Range on HMM: 2-103/105.0
VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
| ....|.||. || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...| . ||.||. |..|...||.|.|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al
subfamily_PTPN1_pd Subfamily PTPN1 1244-1422 4e-23 76.5 In-house 69-264 (290) alignment 
Range on Protein: 1244-1422
Range on HMM: 69-264/290.0
EKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC----GEEDCCYPYWTGPKT-------HDDFVVEITNEIKSNGYMERMFKVSF--DKESRNVLQLQ
 || .|..| |. |||  ||.|. . |  |.|||      |.  |. ||   .        .  . |.. .| ... |. |....     .|.|..|.  
akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfh

VTDWPQDGVVREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSIY
 | ||  || . | . |. . .| .    .   ||.|.|||  . ||| .| |   | . ....    ||. .|  ..|. . | . | .|    |
yttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_PTPRN_pd Subfamily PTPRN 1246-1423 2.3e-22 74.1 In-house 100-286 (297) alignment 
Range on Protein: 1246-1423
Range on HMM: 100-286/297.0
RAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED----CCYPYW--TGPKTHDDFVVEITN-EIKSNGYMERMFKV--SFDKESRNVLQLQVTDWPQ
 |.| .|.|. .|| |||.|. .  |  ||.|.  |.     |. ||  .| .... . |..    | .. |. | | .     .|.| | |.    ||.
payiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpe

DGVVREPRTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
 ||  .....|.    |  .  .    |.|||||| . |.|||. . . |..  |    .|.    . .|  .|| | | .|.  .. 
egvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1109-1226 2.8e-22 74.0 In-house 23-140 (297) alignment 
Range on Protein: 1109-1226
Range on HMM: 23-140/297.0
TTVGFSEQNKP--FNRFKNIAPYDEHMIVLQKKPnmelCEREYINATYIDG--YSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
 .   . .|     ||...|  .|.  . |.. .     ||.|||| |.      .  |.| ||||...|. |||.|....    ||||..|.|. ..||
esfssakrnsslrknryrdilatddtrvkllrvi....terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

EQYWPNGRAESEEFGPFSVTLV
  |||.   |  . | . |  .
apywpsvvqerlkagdvvvefl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1245-1422 3.6e-22 73.7 In-house 51-234 (239) alignment 
Range on Protein: 1245-1422
Range on HMM: 51-234/239.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTGPKT-HDDFVVEITNEIKSNGYMERMFKVSF--DKESRNVLQLQVTDWPQD
 .|.| .|  .| .  |||.|. . .   |||| |     .  |. ||    . . .. | . .      |. | | .|   . | | | | ..| ||. 
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdk

GVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
|| .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
gvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1245-1422 3.6e-22 73.7 In-house 50-233 (239) alignment 
Range on Protein: 1245-1422
Range on HMM: 50-233/239.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTGPKT-HDDFVVEITNEIKSNGYMERMFKVSF--DKESRNVLQLQVTDWPQD
 .|.| .|  .| .  |||.|. . .   |||| |     .  |. ||    . . .. | . .      |. | | .|   . | | | | ..| ||. 
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdk

GVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
|| .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
gvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
0051082 (Phosphotyrosine protein) phosphatases II 1237-1424 3.6e-21 70.8 In-house 9-148 (151) alignment 
Range on Protein: 1237-1424
Range on HMM: 9-148/151.0
RSITGYrekraFIIAQSPMEntvrDFWKMIVDYKVSAIVMLCG--EEDCCYPYWTGPKthddfvveitneiksngymermfkvsfdkesRNVLQLQVTDW
. .||.     ... . |..    ||.... ......||.|..  | . |. |..                                  ..||.....||
syvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...............................ievlhipildw

PQDGVVREPRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
|  |.   . .||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
pdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_egg_pd Subfamily egg 1106-1232 1.7e-20 68.0 In-house 29-153 (307) alignment 
Range on Protein: 1106-1232
Range on HMM: 29-153/307.0
DLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMELCerEYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtkSKCE
. . |  .|. |.   | | .   |   . |. .  . |   ..| | ...|    |.|| || |.| |  ||||...||.   |||.|  ||    .||
eislttaasdnnlekarskrvhckdssrvklelrrGqyld..dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPNGRAESEEF--GPFSVTLVDEQVLP
 |||.  ..|  .  | . .. .. .  .
yywpkaesdslvtvpGslrienlkvdska
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1245-1425 3.1e-20 67.0 In-house 93-279 (290) alignment 
Range on Protein: 1245-1425
Range on HMM: 93-279/290.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGE----EDCCYPYWTGP----KTHDDFVVEITNEI-KSNGYMERMFKVSFDKES--RNVLQLQVTD
|  ||..| ....|| |.|.|... ||.||||||         | .|.        |  .. |  ..|  | .  . ... |   ..     .  |..  
kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkiks

WPQDGVVREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLeQCKAEG-VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
||.  |     ..|...  .  |.     ||||||||  . |.| . .. .|| |.  .|  .|. .. .|.|.|. ..|    ||  . ...
wpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_ptpA1_pd Subfamily ptpA1 1109-1211 1.3e-19 65.2 In-house 39-138 (418) alignment 
Range on Protein: 1109-1211
Range on HMM: 39-138/418.0
TTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYsSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
|. |  ..|   ||. || | .   . |.|  . |    .|||| ||||    ..||..|||. .|. ||||..|...   |||..   |  . ||..||
tsegdkkhntsknrytnilpvnhtrvqlkkiqdke..gsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdryw

PNG
|. 
peq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1120-1213 4.1e-19 63.5 In-house 50-155 (350) alignment 
Range on Protein: 1120-1213
Range on HMM: 50-155/350.0
FNRFKNIAPYDEHMIVLQKKP------NMELCEREYINATYIDGY------SSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQY
 ||.||| ||.   . |.| .      .  |   .|||| |.          .  |.||.|.|...|. ||...| . |   |...|.. |    ||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPNGRA
|..|  
Wqegsy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1120-1229 6.5e-19 62.7 In-house 59-161 (290) alignment 
Range on Protein: 1120-1229
Range on HMM: 59-161/290.0
FNRFKNIAPYDEHMIVLQKKpnmelCEREYINATYIDGYSSanKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFG
 ||.|...  |   ..|.        . .|. | |..|  .   || .||..|.| .|.||.. |||   |||. .| |  |.|||||.|.   |   ||
knrykdvvcndktrvilkdG.....ydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

PFSVTLVDEQ
 ..|.   |.
eitvlcseed
subfamily_CG42327_pd Subfamily CG42327 1117-1235 6.8e-19 62.7 In-house 28-147 (319) alignment 
Range on Protein: 1117-1235
Range on HMM: 28-147/319.0
NKPFNRFKNIAPYDEHMIVLQKKPNMElcEREYINATYIDGYSSA-NKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN--GRA
 |. .|. |. |  |  .|||.... .  . ||..|.|. || .| | .|||| .....  ||||..|. .   || .|.| |    .| .|.|   .  
skdksrvinvvPlPetrvvlqrigddd..kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

ESEEFGPFSVTLVDEQVLPDFV
. . .| . ||| . .|   ..
ntslyGdilvtlkgrevkdrya
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1240-1430 6.9e-19 63.1 In-house 54-260 (290) alignment 
Range on Protein: 1240-1430
Range on HMM: 54-260/290.0
TGYREKRAFIIAQSPMEN-------TVRDFWKMIVDYKVSAIVMLCGEED---------CC--YPYWTG-PKTHDDFVVEITNEIKSNGYMERMFKVSFD
  . .  ..|. ||| |.       |. .|| |. . ||  .||||  |.         |   .|   |   . ... |. .. .| ..  .|   | ||
vtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd

KESR-NVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVRRSKPGAVTTLEQY
.|    |   .. .| .  | ....|.|..|. |  ..      ||.||| | .||| .  .. .|       .| | . .| ||.|. .  |.|. ...
deeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalel

TSIYDVIDMYLQ
. .  .| ....
afvdagivllai
0049772 (Phosphotyrosine protein) phosphatases II 1240-1431 1.1e-18 63.5 In-house 81-282 (314) alignment 
Range on Protein: 1240-1431
Range on HMM: 81-282/314.0
TGYrekRAFIIAQSPMENTVRDF----------WKMIV--DYKVSAIVM---------------------LCGEEDCCyPYWtGPKTHDDFVveitneik
 |.   ..||..| |.|.|| ||          |.|..  |..|  |||                     |..      ...  ... ...         
dgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.nep.taadlellk........

sngymerM-------FkvsfdkeSRNVLQLQVTDWPQdGVVREPRTVLQVIdDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGVvDVFQ
               |       .|.....  ...|  | .  .. ..... ..|..     ||||.|||.. ..|.|... . . . ..   || .. .
.......eelydpelf.......erlgikylripvpD.gsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.slee

VTKAVRRSKP-----GAVTTLEQYTSIYDVIDMYLQM
. . ||.  |     |.. .||||  |.... .||..
aledvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1105-1231 1.3e-18 61.6 In-house 26-150 (281) alignment 
Range on Protein: 1105-1231
Range on HMM: 26-150/281.0
EDLPTTVGFSEQNKpFNRFKNIAPYDEHMIVLQK-KPNMElcEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSK
 || |..    .||  ||. ||   |   . |.   || .    .|| | ||        .| .||| |.|  ||||.||||.  .|||. .. |  . |
sdlctvfnqpvnnk.knrylnipcldisrvqlkvkmpnkn..stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrek

CEQYWPNGRAESEEFGPFSVTLVDEQVL
| .|.|       .|  .||.  |  | 
caeyfprnahcclqfdklsvsyedstvn
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1245-1428 3.4e-18 60.7 In-house 81-276 (307) alignment 
Range on Protein: 1245-1428
Range on HMM: 81-276/307.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGPKTHDDFVVEITNEIKSNGY-ME-----------RMFKVSFDKESRNVLQ
 . || || |.|||. .|| |... || ...|||   .     |  ||   .      .| .| |  .   ..             .|| . ..|| . .
pkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqh

LQVTDWPQDGVVREPRTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIGLEQ-CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
|| ..||. || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  .. |.  
lqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

Y
|
y
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1090-1209 5.2e-18 60.0 In-house 4-116 (267) alignment 
Range on Protein: 1090-1209
Range on HMM: 4-116/267.0
NNTAFNQQYQELYTGEDLPTT--VGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNMelcereYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKP
... ........    |  .|    ..|.|. .||. .  |||. ...|..| .       ||||.|..||   |.||. |.|.|.|  ||. .| ..| 
eeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkv

VSIVMVTNLKEGtksKCEQYWP
  ||..|.  ..   .  ..||
pvivlltkvftd...nirlfwP
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1113-1220 7.2e-18 59.6 In-house 37-140 (307) alignment 
Range on Protein: 1113-1220
Range on HMM: 37-140/307.0
FSEQNKPFNRFKNIAPYDEHMIVLQKKPnmelCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
  . |   ||....   |   ||.. .        .|| | |.      .|||.||||...|  .|| .. |||  |..|. .. | .| |||||||  .
afsantdknryqdvkcqdkgrivvkfdg....lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

AESEEFGP
 .   || 
gqklvfge
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1241-1431 9.3e-18 59.3 In-house 77-273 (288) alignment 
Range on Protein: 1241-1431
Range on HMM: 77-273/288.0
GYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC-----GEE--DCCYPYWTGPKTHDDFVVEITNEIKsnGYMERMFKVSFDKESRNV------L
  . || .| ||.|.. |.  .|||...  |  |||||     | |  .  .|   | |..   .  .. . .    .... |||  . |...       
sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr..adidklvkvsllriskegeekvivk

QLQVTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
.| . .|..|||  .  . |.... . .  ||    |.|||.|  | |.|    . | ||. . .  . . .. .  | ..  |..|  ||  .. ..  
ilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvle

YLQM
.| .
elll
0044763 (Phosphotyrosine protein) phosphatases II 1239-1432 9.7e-18 59.9 In-house 26-174 (178) alignment 
Range on Protein: 1239-1432
Range on HMM: 26-174/178.0
ITGYrekraFIIAQSPMentvRDFWKMIVDYKVSAIVMLCGEEDCC----YPYWTGPKThddfvveitneiksngymermfkvsfdkesrnvL---QLQV
|...     ..... |.     |..... ......||.|..|  .     .|||                                      .   .. .
ilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................................iqylhipi

TDWPQDGVVREPRTVLqvidDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRRSKPgAVTTLEQYTSIYDVIDMYLQM
 |..   . .  . ..    . |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .|.  .|..  ..|..
pDhgvpdllehflefv....efieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrllke

N
.
s
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1095-1228 1.7e-17 58.0 In-house 30-159 (310) alignment 
Range on Protein: 1095-1228
Range on HMM: 30-159/310.0
NQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPNmelCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVT
 .||. | . .|   |    ...   ||. ..   |.  . |.          .|| | |.      . || .|||...|..||||.|.||.  ||... 
vkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidks...ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

NLKEGTKSKCEQYWPNGrAESEEFGPFSVTLVDE
.  |  . ||  |||     .| .|   || . |
kvgeegrpkcvgywpsl.gvtetygcirvtnlse
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1244-1425 1.7e-17 58.0 In-house 79-265 (281) alignment 
Range on Protein: 1244-1425
Range on HMM: 79-265/281.0
EKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTG----PKTHDDFVVEITNEIKSNGYMERMFKVSFDKESRNVLQLQVTDWP
 || .|..| | ..|  |||.|| . . .||||||     . . |  |.          | . |.  .    .  .   ...|.. |.| . .    .||
lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewp

QDGVVREPRTVLQVIddvihRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRS-KPGAVTTLEQYTSIYDVI
.  |      .|...     |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| . .  .| ||.||  |. |.
dwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
0051429 (Phosphotyrosine protein) phosphatases II 1148-1242 8.9e-17 57.1 In-house 5-111 (272) alignment 
Range on Protein: 1148-1242
Range on HMM: 5-111/272.0
EYINATYIDGYSS---ANKFIAAQGPMKKTLVDFWRLiWQEKPVSIVMVTNLKEGTKSKCEQYWP----------NGRAESEEFGPFSVTLVDEQVLPDF
 |||| ...|| .    .......||.. |  ||||| ....  .||..... |  . ||..|||          .  |.. ..| ..|||. |..|.|.
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VIRSITGY
..| .. .
ilrelllt
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1245-1417 9.7e-17 55.6 In-house 89-269 (301) alignment 
Range on Protein: 1245-1417
Range on HMM: 89-269/301.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGE----EDCCYPYW---TGPKT-HDDFVVEITN--EIKSNGYMERMFKVSF---DKESRNVLQLQV
 . ||..|.|..||  ||| |.| |.|  ||||. .    |. |  |    .. |   . | ..|.|   | ..  ..| ..|     . ..| |.  | 
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqy

TDWPQDGVVREPRTVLQVIDdVIHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQ
..|.. || .    . .... .. . .|    |.|||||. . ||  . .  .   . .|.  ... .  | .|  .  .| | .|
sewtdrgvPkshaelfdlme.lvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1075-1169 1.2e-16 54.7 In-house 6-95 (95) alignment 
Range on Protein: 1075-1169
Range on HMM: 6-95/95.0
SISDLGTHVASYHSDNNTAFNQQYQELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKPnmelcEREYINATYIDGYSSANKFIAAQG
 .| . .||   ||. .  |..... .      | ||| || | | ||| || |||   .||  |      . .|||| ..|||.  | .|||||
hvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr.....dsdyinacfvdgyarkncyiaaqg
subfamily_egg_pd Subfamily egg 1239-1429 1.6e-16 54.9 In-house 76-270 (307) alignment 
Range on Protein: 1239-1429
Range on HMM: 76-270/307.0
ITGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED--CCYPYWtgPKTHDDFVVE------ITNeIKSNGYMERMFKVS------FDKESR
. |      ||.||.|. ||| |||.|.   .|  ||||    .   |  ||  ||...| .|       |.| .| .   . .|.|.       |.| |
vkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyyw..pkaesdslvtvpGslrien.lkvdskadplfrvtklklvGgddeer

NVLQLQvTDWPQDGVVREPRTVLQVIddvihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV--DVFQVTKAVRRSKPGAVTTLEQYTSIY
 .   |  |. . . |  |  ||. .     |.      ||||.. . ||....  .. | | .     ..   | .  . .|. .. .| .  .|  .|
flehwq.gdvnnssdvysplrvlrkl.....rnl...skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvy

DVIDMYL
 .. ...
rlvlfff
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1244-1428 1.6e-16 54.8 In-house 95-288 (305) alignment 
Range on Protein: 1244-1428
Range on HMM: 95-288/305.0
EKRaFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGPKTH-----DDFVVEITNEiksNGYMER-------MFKVSF-DKESRNV
||| || || |...|. .|| |... ||  |||||   .     |  ||   .          |||       .  |||       ......  ...  |
ekr.ficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsg...skpmerdaeiqitllnltysgdqkmsv

LQLQVTDWPQDGVVREPRTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIGLEQCKA-EGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 .|| |.||. ||     | |...  .  |  |.   |.|||||  . |.|   ..   ||.      .  . .. ||.|  .  .. .  ||  |. |.
rhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvm

DMY
  |
lny
0041856 (Phosphotyrosine protein) phosphatases II 1117-1211 3e-16 55.0 In-house 1-74 (182) alignment 
Range on Protein: 1117-1211
Range on HMM: 1-74/182.0
NKPFNRFKNIAPYDEHMivlqkkpnmelcEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtkskCEQYWPNG
|.. ||...| |||  .               |||| ...|.  |..|||.|||...|. ||.|......  .||..|         .|.|||. 
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpel
0049772 (Phosphotyrosine protein) phosphatases II 1110-1210 1.1e-15 53.6 In-house 39-165 (314) alignment 
Range on Protein: 1110-1210
Range on HMM: 39-165/314.0
TVGFSEQNKPFNRFKNIAPYDeHMIVLqkkPNMELCEREYINATYIDGYssaNKFIAAQGPMKKTLVDF----------WRLI--WQEKPVSIVM-----
.|.  . |.  ||...| |.| .  .|   |...     |||| |.||.   .||||.|||.. |.|||          ||..  .. ..  |||     
lvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------VTNLKEGTKSKCEQYWPN
                 ..| ...   .......
ladelsrLdaAlgKtpllildgngneptaadlel
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1114-1227 1.2e-15 52.3 In-house 32-140 (285) alignment 
Range on Protein: 1114-1227
Range on HMM: 32-140/285.0
SEQNKPFNRFKNIAPYDEHMIVLQKKpnmelcEREYINATYIDGYS-SANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGR
 | |  .||. ..   .|  .||...      .|.|| |...       . .|..|||. .|| |||..|.|||   ..|.  | ||   ||  |.|.  
yeanpdlnryadvrcieetrvvlknh......drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

AESEEFGPFSVTLVD
 |  .|| . .|| .
gevvkfgkyeitlte
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1116-1215 4.6e-15 50.1 In-house 47-141 (305) alignment 
Range on Protein: 1116-1215
Range on HMM: 47-141/305.0
QNKPFNRFKNIAPYDEHMIVLqKKPnmelCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAES
|..  ||.|..   |.  . | . |       ||| | |.   . ...|| .| |..||  ||| . .|.|  .| |. ||.|    || .|..    . 
qeagknrykdvgcldnnrvkl.egp....wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1117-1217 4.9e-15 49.9 In-house 55-151 (305) alignment 
Range on Protein: 1117-1217
Range on HMM: 55-151/305.0
NKPFNRFKNIAPYDEHMIVLQKkPNmeLCerEYINATYIDGYS-SANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAES
..  ||....   |. .. |.| |.   .  .|| | |.       ..||.||||. .|. .|| .. |.|   |||. .  |  | || ||||  . | 
aitknryqdvpcqdqsavkldk.ps..ps..dyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

EE
 |
le
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1244-1424 2.5e-14 47.9 In-house 3-199 (199) alignment 
Range on Protein: 1244-1424
Range on HMM: 3-199/199.0
EKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEE---DCCYP-YWTGPKT----HDDFVVE-ITNEIKSNGYMERM---FKVSFDKESRNVLQLQV
 .| .| .| |. .|. |||.|. .     |||.  ..   .. || ||   ..    .  . |   |   |..  .  .    ...    .|.. . | 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
| | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1245-1424 3.5e-14 47.4 In-house 3-198 (198) alignment 
Range on Protein: 1245-1424
Range on HMM: 3-198/198.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEE---DCCYP-YWTGPKT----HDDFVVE-ITNEIKSNGYMERM---FKVSFDKESRNVLQLQVT
.| .| .| |. .|. |||.|. .     |||.  ..   .. || ||   ..    .  . |   |   |..  .  .    ...    .|.. . | |
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
0048076 (Phosphotyrosine protein) phosphatases II 1277-1428 4.6e-14 47.8 In-house 36-142 (145) alignment 
Range on Protein: 1277-1428
Range on HMM: 36-142/145.0
LcgeedccypywtgpkthddfvveitneiksngymermfKVSFDKESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRS
|                                         .. ..|...|.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.
l......................................tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRt

GVYCsvsiGLEQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
|...    ..  .. .| |..... . ||.  ||||.. .|.  .|... ..
gtlv....aaylmlllg.vsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_ptpA1_pd Subfamily ptpA1 1245-1386 9.7e-14 45.9 In-house 88-253 (418) alignment 
Range on Protein: 1245-1386
Range on HMM: 88-253/418.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED-C---CYPYWTG-------------PKTHDDFVVEITNEIKS--NGYMERMFKVSFDKESRN
 . || .| |. ||. |||.|. . ..  ||||  | . |   |  ||                .    . ||. . |.      . |  ...|. |.|.
pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrd

VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIGL
. | |   ||.  .    . . |..  .  ||..|        |..||||  | |.| .|.  | .
itqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
0036282 (Phosphotyrosine protein) phosphatases II 1148-1218 1.2e-13 46.6 In-house 3-68 (174) alignment 
Range on Protein: 1148-1218
Range on HMM: 3-68/174.0
EYINATYIDGYSSANKFIAAQGPMKktlvdFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEF
 ||||...|..   ...|| |||..     ||.......  ..||....||  . || .|||  |   |..
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1146-1231 3.3e-13 44.1 In-house 74-160 (301) alignment 
Range on Protein: 1146-1231
Range on HMM: 74-160/301.0
EREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQV-L
.|  | | .|.    ...|||.|||.|.|  ||| .. | .   |||...  | ...|||.| |   .|. . | |......... |
krvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelil
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1247-1342 3.9e-13 43.9 In-house 77-182 (297) alignment 
Range on Protein: 1247-1342
Range on HMM: 77-182/297.0
AFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC----GEEDCCYPYWT----GPKTHDDFVVEITNEIKSNgYMER---MFKVSFDKESRNVLQLQVTDWP
 .|.|| |...|| |||.....  | .|||..    .  | |.|||     . ..  |.|||   .   . .       ... . .||| |   |   ||
kyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswp

QDGVVRE
. ||  .
dhGvpsd
0048179 (Phosphotyrosine protein) phosphatases II 1264-1423 4.5e-13 44.6 In-house 23-139 (144) alignment 
Range on Protein: 1264-1423
Range on HMM: 23-139/144.0
KMIVDYKVSAIVMLCGEEDCCYPYWTgpkthddfvveitneiksngymermfkvsfdkesrnVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGG
... ........ |. | .  ..  .                                    ..|.. ..||  ||   .  .|.... . . ..   ||
ellkklgittvinlteeyepeflere....................................giqylhlpwpDhgvpdllellleflefieeale..egg

PVVVHCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
||.||||  |.|.|...        .| .| ...... . ||.  ||||.. .|.  ...
pvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1244-1433 1.2e-12 42.2 In-house 86-291 (305) alignment 
Range on Protein: 1244-1433
Range on HMM: 86-291/305.0
EKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEE----DCCYPYWTGPKtHDDFVVEITnEIKSNGYMERMFKVSF------------------DK
. . || .|.|.|.|  ||| | .. || || |||         |. |..  . .| .  |   . |    .|   ...|                   .
npkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd.kdvlefeek.gqkisvkfessvtlkfrkdakakvtetvlviegpge

ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV-DVFQVTKAVRRSKPGAVTTLEQYTS
..| | .    |||. ||     ..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  .. . .|  .  .. | .||  
karkvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylf

IYDVIDMYLQMNS
...||  |.. . 
vhqvilnyfrkkk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1245-1424 1.4e-12 41.9 In-house 93-285 (310) alignment 
Range on Protein: 1245-1424
Range on HMM: 93-285/310.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGE--ED--CCYPYWTGPKTHDD-FVVEITNEIKSNGYMERM-F-------KVSFDKESRNVLQLQV
. .|| .| |.. |. |||.|| . .  .|..||    |    |  ||      .   .. .||  .|   .|   .       .|  |..  |. .|.|
rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrv

T-----DWPQDGVVREPrtvLQVIDDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
.     .||. ||  |     . . . .  |  .  ||.|||||  . | .| ... . ... .    ||. .|   ...|.   . |  ||. |  |
slikwpnwpdrgvpdek...chtvpqrllaq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1156-1224 3.9e-12 40.2 In-house 230-294 (440) alignment 
Range on Protein: 1156-1224
Range on HMM: 230-294/440.0
DGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTkskCEQYWPNgRAESEEFGPFSVT
.|||  | |||.| |.  |..|||||. . .  .|.|. .|.. |   |  |||   . |  ||||.| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpv.ntrsvtfgpftvg
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1246-1431 5.1e-12 39.8 In-house 90-287 (302) alignment 
Range on Protein: 1246-1431
Range on HMM: 90-287/302.0
RAFIIAQSPMENTV---RDFWKMIVDYKVSAIVMLCGEEDC------CYPYWTGP-KTHDDFVVEITNeIKSNGYMERMFKVS--FDKESRNVLQ--LQV
|  |.|| |  ...    .||.|. . |.  .|.| |||..       .|  .|  |..... | .   ...   .. .. .    .  |  ||     .
rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvl

TDWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
| |.|. |  .  .. . . .| . ..  .  ..|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|.||.|.| .. .|.. 
tnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_CG42327_pd Subfamily CG42327 1362-1429 6.4e-12 39.8 In-house 247-315 (319) alignment 
Range on Protein: 1362-1429
Range on HMM: 247-315/319.0
GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
 ||.|||||| | |.|.  .  | ... .     ||. |.   ||| .  || | |||  || |. .| 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
0046846 (Phosphotyrosine protein) phosphatases II 1149-1211 1e-11 40.4 In-house 14-72 (176) alignment 
Range on Protein: 1149-1211
Range on HMM: 14-72/176.0
YINATYIDGYssanKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNG
|||| .|.|.    ..|| |||. .|| ||........   .|..|...|  . || .|||  
yinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpel
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1253-1421 1.4e-11 38.4 In-house 98-280 (302) alignment 
Range on Protein: 1253-1421
Range on HMM: 98-280/302.0
SPMENTVRDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTG----PKTHDDFVV---EITNEIKSN--GYMERMFKVSFD------KESRNVLQLQVTD
 |  .|.  .| .| .|.|. .| ||.    ||  | .|..       .   . |   .. ....        ....| .       |  . |  |. . 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPQDGVVREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
||. |  .|. | |...      ...     |.||||  | |.|   ..  |.. |. . | |. .. . ||. . ||| . .| . .
wpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
0043147 (Phosphotyrosine protein) phosphatases II 1147-1201 1.8e-11 39.6 In-house 5-55 (172) alignment 
Range on Protein: 1147-1201
Range on HMM: 5-55/172.0
REYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLkegtK
. |||| |.|.|   ..||| |||.  || ||||......   ||..|.|     
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel....l
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1120-1212 4.7e-11 36.6 In-house 51-157 (349) alignment 
Range on Protein: 1120-1212
Range on HMM: 51-157/349.0
FNRFKNIAPYDEHMIVLQKKPNMEL-----------C-EREYINATYID--GYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCE
 ||.|.| ||.   ..|.| ..              .   .|||| |.    .|  .|.|| | |.  |. ||...|  ..   .. ... || .  ||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWPNGR
.|| .. 
iywqels
fn3 Fibronectin type III domain 489-578 4.8e-11 35.8 Pfam-A 1-85 (85) alignment 
Range on Protein: 489-578
Range on HMM: 1-85/85.0
SPVTSLSVFNVSTTGITVKWTIP-SSDNYVTYYTISYTPSCPELssVNETVSVAPHqsttTYSYTLIGLYSGMNYTITVRAGNVLGGSDPS
|... ||| .|..| .|..|. | . .  .|.|.. | ..  .   .  ...| ..    |.|.|| ||  |..|...|.| |  |.. .|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprt....ttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 590-679 4.8e-11 35.8 Pfam-A 1-85 (85) alignment 
Range on Protein: 590-679
Range on HMM: 1-85/85.0
SPVTSLSVFNVSTTGITVKWTIP-SSDNYVTYYTISYTPSCPELssVNETVSVAPHqsttTYSYTLIGLYSGMNYTITVRAGNVLGGSDPS
|... ||| .|..| .|..|. | . .  .|.|.. | ..  .   .  ...| ..    |.|.|| ||  |..|...|.| |  |.. .|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprt....ttsvtltgLkpgteYefrVqavngagegpeS
0049260 (Phosphotyrosine protein) phosphatases II 1154-1208 5.8e-11 37.8 In-house 1-55 (152) alignment 
Range on Protein: 1154-1208
Range on HMM: 1-55/152.0
YIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
.||||   ..|||.|||.  || ||||.... .   |||.|.| | .| |||||.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1162-1238 1.2e-10 35.9 In-house 5-81 (199) alignment 
Range on Protein: 1162-1238
Range on HMM: 5-81/199.0
NKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRS
 ..||.| |...|. |||...|.     |||| . .   ..    |||   . . ..| .|||     . ||..| .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytita
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1162-1238 1.5e-10 35.6 In-house 4-80 (198) alignment 
Range on Protein: 1162-1238
Range on HMM: 4-80/198.0
NKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRS
 ..||.| |...|| |||...|.     |||| . .   ..    |||   . . ..| .|||     . ||..| .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytita
fn3 Fibronectin type III domain 218-291 1.9e-10 33.9 Pfam-A 2-78 (85) alignment 
Range on Protein: 218-291
Range on HMM: 2-78/85.0
APSSLTEVSKTTTTITVSWTAL--NSSDADGYVVNVTSDTDT--VQTVQLEGISNnTITLNGLNIETTYSITVRAYQE
||. |.  . |.|..|.||..   .... .|| | . .....   ....... .. . ||.||.  |.|...|.|. .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavng
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1119-1221 1.2e-09 32.6 In-house 45-141 (288) alignment 
Range on Protein: 1119-1221
Range on HMM: 45-141/288.0
PFNRFKNIAPYDEHMIVLQKKPNMelcereYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEF
  .|..|.   |   . |.  |..      ||.|  .      ...| || |.. |.  .|... ..    |||...| |  | | ..|.|    |.  .
trdryenlprcditrvklsddpdf......yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GPF
| .
grl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1247-1430 1.2e-09 32.3 In-house 83-277 (312) alignment 
Range on Protein: 1247-1430
Range on HMM: 83-277/312.0
AFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGE----EDCCYPYWTG---PKTHDDFV--VEITNEI----KSNG-YMERMFKVSFDK---ESRnVLQL
 |...|.|.|||.  ||.. .    ..|..|||      . |  | .        .|     |   ||    ||.     |..||       ||. . . 
rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhy

QVTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYC---SVSIGLEQCKAEGVVDVFQVtkaVRRSKPGAVTTLEQYTSIYDVID
| . ||. |.     | |...  | ....|    ||. |||  | |.|  .   |.   | . . . | |.| .   .|. .  .| .. ||     .. 
qwaswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvl

MYLQ
 .| 
efly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1243-1435 1.6e-09 32.1 In-house 72-276 (285) alignment 
Range on Protein: 1243-1435
Range on HMM: 72-276/285.0
REKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC-----GEEDCC--YPYWTGPKTH-DDF---VVEITNEIKSNGYMERMFKVSFDKESRN---VLQ
... ..| .| |. .|. |||.|| . |.. ..|||     | | |.  ||   |   .   .   . |  .|  .   .. .  .  .  | .   . .
kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnh

LQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
.||  ||..    . | ....   | . . |    |..||||  | |.  .  .     .   .  ...... . .|  .  || .  |.  .| |.  |
vqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey

LQMNSII
.  . ..
figegvv
fn3 Fibronectin type III domain 404-470 3.7e-09 29.8 Pfam-A 2-76 (85) alignment 
Range on Protein: 404-470
Range on HMM: 2-76/85.0
PPNNVRGFILNATSIKVNWTTS----SEINGYVIEYTTGGVT--RNVVSTSEE--EIVLTDLSPMSTYTISVYSY
.| |..    ..||. ..|. .    ..| || .|| . | .   . .....   . .||.| | ..|...|...
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1229-1320 6.8e-09 29.9 In-house 99-181 (350) alignment 
Range on Protein: 1229-1320
Range on HMM: 99-181/350.0
QVLPDFvirsitgyrekrAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGpKTHDDFVVEITNEIKSNGYMERMFKVSFD
.. |||             .| .|.|. .|| ||.|.|.  ||  |..|  . .     || ||    . ||. | ...  .. . .. . . |.|
einpdf............kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqe.gsydditvklaskwenimgindsslysad
fn3 Fibronectin type III domain 706-770 1.2e-08 28.1 Pfam-A 18-85 (85) alignment 
Range on Protein: 706-770
Range on HMM: 18-85/85.0
LTWNEVNcsERNGLITGYTVIISNS-----SITYYLTSTERYIILNDLVFGTEYNISVAAVNSVGRGPFS
|.|.. .  ...| ||||.|  ...     . .. ...|..  .|..|  ||||...|.||| .| ||.|
lsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
0051082 (Phosphotyrosine protein) phosphatases II 1148-1210 3e-08 28.9 In-house 4-55 (151) alignment 
Range on Protein: 1148-1210
Range on HMM: 4-55/151.0
EYINATYIDGYssankFIAAQGPMKktlvDFWRLIWQEKPVSIVMVTNLKEGTksKCEQYWPN
 |||..|..|.     ... .||.     ||..|.....  .||......|    .| .|.|.
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpe
0044763 (Phosphotyrosine protein) phosphatases II 1129-1210 3.5e-08 28.8 In-house 2-72 (178) alignment 
Range on Protein: 1129-1210
Range on HMM: 2-72/178.0
YDEHMIVLQKKPNMELceREYINATYIDGYssanKFIAAQGPmkktlVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN
.|..  .|.. ...|    .||||..|...     ......|     .|...|.....  .||..|. .|. . || .||| 
ldrtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpe
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1364-1425 1.4e-07 25.7 In-house 230-291 (297) alignment 
Range on Protein: 1364-1425
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||||.. .||..
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1118-1208 1.5e-07 25.5 In-house 44-128 (312) alignment 
Range on Protein: 1118-1208
Range on HMM: 44-128/312.0
KPFNRFKNIAPYDEHMIVLQKKPNMelcereYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
| .||. ||  .|   . |    |.      || | ..   .  ..|...|||...| . ||.|      .||.... . | .  || .| 
kdlnrypniqcwdrgrftlagdenf......yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi
DUF1517 Protein of unknown function (DUF1517) 910-986 3e-07 17.5 Pfam-A 17-95 (289) alignment 
Range on Protein: 910-986
Range on HMM: 17-95/289.0
SSSVSTTRDTSTTTSLVQPST--TaSTS-PpavAGDTGLS---PVVLGGAGGGALVGILIVIVLILIVVLVLRRKKRSKDTLY
|.|.|. |  | . .  . |.  . ...     .| .| .   |..  | |.. |.|.||..... ..| .||.......  .
srssssprssspsgggygsssssy.gggys...gggfgfpflipifgfGggflglfgllilvaivgvlvnalrsagggeeges
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1258-1426 3.6e-07 24.5 In-house 40-219 (255) alignment 
Range on Protein: 1258-1426
Range on HMM: 40-219/255.0
TVRDFWKMIVDYKVSAIVMLCGEED----CCYPYWTG----PKTHDDFVVEITNEIKSNGYMERMFKVSFD--KESRNVLQLQVTDWPQDGVVREPRTVL
||  |...||  | . .||||  ..     |  |.       .   |  |  |. .       .     .   |. ..|   . . |..    ...| .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

QVIDDVihRQQKigggPVVVHCSDTVSRSGVYCSVSI-------GLEQCKAeGVVDVFQVTKAVRRSKPGAVTTLEQY-TSIYDVID
...  |  |. |    .||||||  . ||  .  . .        |.. .. . .|  .. . .| ....|. |  |   ||. |.|
nilkvv..rdsk....svvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraihtPlqlafsilmvld
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1366-1425 3.6e-07 24.5 In-house 2-61 (69) alignment 
Range on Protein: 1366-1425
Range on HMM: 2-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1120-1204 6.6e-07 23.1 In-house 37-118 (332) alignment 
Range on Protein: 1120-1204
Range on HMM: 37-118/332.0
FNRFKNIAPYDEHMIVLQKKPnmelCEREYINATYIDGYSSANKFIAAQGPMK-KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
.||   .  .|   . |  .      . .. ||...||||  . .| || |.. .|   |||.. . ||  |... .. |  | |.
mnriphlycfdhsrvelapqd....gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_hpo-7_pd Subfamily hpo-7 1256-1430 8.8e-07 23.1 In-house 44-229 (263) alignment 
Range on Protein: 1256-1430
Range on HMM: 44-229/263.0
ENTVRDFWKMIVDYKVSAIVMLCG--EE--DCCYPYWT----GPKTHDDFVVEITNEIKSNGYMERMFKVSFD--KESRNVLQLQVTDWPQDGVVREPRT
 .|.  |...||  | . .||||   ||  . |  |.     . .   .  |  |. ..      . .   ..  |. ..| . . . |..   ....| 
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

VLQVIDdvIHRQQKigggPVVVHCSDTVSRSGVYCSVSIG-------LEQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQY-TSIYDVIDMYLQ
.|....  . |. |    ..|||||  . ||  .  . .        |.. .  . .|  .. . .| |...|. |  |   ||. |.|. |.
ilnilk..varnsk....slvvhcstGiGrsaafsvaElvyqkmirsldtts.tveldylsLleelrssrkraihtPmqLafsilmvLdfvln
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1244-1340 9.4e-07 23.2 In-house 25-127 (130) alignment 
Range on Protein: 1244-1340
Range on HMM: 25-127/130.0
E-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGEEDCcYPYWTGPKT----HDDFVVEITNEIKSNGYMERMFKVSFDKE-S-RNVLQLQVTDWPQ
.  . .. .| |. .|  |||||...  |  .|.|   |.    ||   .      .| .| .|.  ...      .... |   | . .  .|...|| 
grtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.deywpdsePlewyeediivtltdrdefknikasnleiesdlneshqaltmfqisnwps

DGVV
||  
dgtt
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1099-1213 9.8e-07 22.6 In-house 78-183 (244) alignment 
Range on Protein: 1099-1213
Range on HMM: 78-183/244.0
QELYTGEDLPTTVGFSEQNKPFNRFKNIAPYDEHMIVLQKKpNMelcEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWqEKPVSIVMVTnlke
|..   .       |. .|   ||     |.|   . | |  .|      ||||...     . ..| .| |.  | .|||...  |. | ...|     
qniirpdpsvmkdafnpnnswknregaglpfdfnrvplskg.sm...gntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvl....

GTKSKCEQYWPNGRA
|.  . ..|||.   
gsveeedeywpdsep
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1366-1429 9.8e-07 23.0 In-house 1-64 (69) alignment 
Range on Protein: 1366-1429
Range on HMM: 1-64/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| .   |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1247-1340 1.1e-06 22.5 In-house 138-236 (244) alignment 
Range on Protein: 1247-1340
Range on HMM: 138-236/244.0
AFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCG--EEDCCYPYWTGP-KTHDDFVVEITNEIKSNGYMERMFKVSFD-KESRNVL-QLQVTDWPQDGVV
 .|..| |. .|  |||||... .|  .|.|    |||  .|         .|  | .|.  .        ...  | .|| . |  .|...|| ||  
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgtt
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1147-1238 1.2e-06 22.8 In-house 46-147 (290) alignment 
Range on Protein: 1147-1238
Range on HMM: 46-147/290.0
REYINATYIDgYSSANKFIAAQGPMKKT-------LVDFWRLIWQEKPVSIVMVTNLKEGTKS----KCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFV
 .|| | ..  ...  ..|. | | .|.       . .|| .. |||  ..||. . .| ..      |..| |.   |.  |. ..|   .     |. 
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

IRS
.| 
tRe
fn3 Fibronectin type III domain 787-879 1.4e-06 21.5 Pfam-A 8-85 (85) alignment 
Range on Protein: 787-879
Range on HMM: 8-85/85.0
VSSImDTTWAVISWSVPSfiPSDYPIITYEIGYHILQSGNcsivddddidiqmLQLSNSTNGNT-FINITGLNDISCYIFGVRAYTDNGYGEWT
||..  .| ...||| |.  . . ||  ||. |   ..|.                . .. ..|   ..|||.  . | | |.|....|.|...
vsev.tstsltlsWsppk..dgggpitgYeveyrekggge.............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1108-1194 1.4e-06 22.1 In-house 26-117 (347) alignment 
Range on Protein: 1108-1194
Range on HMM: 26-117/347.0
PTTVGFS--EQNKPFNRFKNIAPYDEHMIVLQ-KKPNMELCE--REYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVT
|. . ..  |..   || |.    |.  .||  .| ..  ..    ||||..|    . ...| .| |. .|. |||...   |   .| . 
pskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_eak_pd Subfamily eak 1124-1225 1.9e-06 21.5 In-house 58-156 (332) alignment 
Range on Protein: 1124-1225
Range on HMM: 58-156/332.0
KNIAPYDEHMIVLQKKpnmELCEREYINATYIDGYSSANKFIAAQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSV
 .| ||| ... |       | .  ||||. ..     .|.| .  . .. .  ||... ..|  .||.. .  |    | ..|.|.   |  .|| . |
vkivpydrylvrltss...qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildv

TL
. 
er
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1325-1387 4.1e-06 20.7 In-house 216-287 (350) alignment 
Range on Protein: 1325-1387
Range on HMM: 216-287/350.0
NVLQLQVTDWPQDGVVREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLE
 |.||||  |.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....   |.
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDslls
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1174-1237 4.2e-06 21.0 In-house 40-101 (255) alignment 
Range on Protein: 1174-1237
Range on HMM: 40-101/255.0
TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDeqVLPDFVIR
|.  |.. | | |.  .||.....| .. ||..|.|  . |   .   .||  .     | |.|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlr
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1245-1434 4.5e-06 20.5 In-house 83-284 (303) alignment 
Range on Protein: 1245-1434
Range on HMM: 83-284/303.0
KRAfIIAQSPMENTVRDFWKMIVDYKVSAIVMLC--GEEDCCYPYWTGPKTHD-----DFVVEItNEIK----SNGYMERMFKVSFDKESRNVLQLQVTD
|.| |..| |.  |  |||.||.. ||  ...|   .| |        |.  |     . .. .  |.|    ..|.  ..  ||  .    .   .  .
kka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirv.gefkrvelgdgwvlkvlsvsngdyksflhvhhyka

WPQDGVVRE--PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIG-LEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
||.. .  .  |. | |. .     ..   . | |      . |.| ..      |   . .  .|. .. . ||  .  ||  | |.. .| ..  .. 
wphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl

MNSI
 | |
dngi
subfamily_hpo-7_pd Subfamily hpo-7 1173-1239 8.1e-06 19.9 In-house 45-109 (263) alignment 
Range on Protein: 1173-1239
Range on HMM: 45-109/263.0
KTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVlpDFVIRSI
.|.  |.. | | |.  .||... .|  . ||..|.|  . |   .   .|.  . |   | .....
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktl