Gene PTPRD-65 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP123_AA protein Get Run
AqueP123_AA_0-165 phosphatase_domain Get Run
AqueP123_AA_170-399 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 246-403 4.2e-88 289.9 In-house 125-298 (301) alignment 
Range on Protein: 246-403
Range on HMM: 125-298/301.0
ESCYQYWSKTDSIKFGEYFVESTSHH-----DF--------------NGYTERKFHIRSDKddsSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ
..|.|||....  .  ..... | ..     ||              |||.||||...|||   |||||.||||||||||||||||||||||||||||||
skceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtvLqviddvihrq

QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMNSM
|||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||.||.
qkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-184 7.7e-81 266.6 In-house 119-303 (305) alignment 
Range on Protein: 1-184
Range on HMM: 119-303/305.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKG-P
|.|.|.|| |.||.||||.  .|..|||.|||.| .|.  .|...| ... |.|....|.|..||.||.|||||||.. | |. | .. .|... .|| |
mltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvp

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKLK
.||||||||||||.|||.|||||..|.| |||.......||..|||||||||||||||| . | |.||.|.|  .|.   |.|||
llVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklk
subfamily_PTPRD_pd Subfamily PTPRD 1-245 2.1e-78 259.4 In-house 121-375 (564) alignment 
Range on Protein: 1-245
Range on HMM: 121-375/564.0
MVTNLKEGTKSKCEQYWPNGrAeSEEFGPFSVTLVDEQVLPDFVIRSITVmIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|.|.|.| .| ||..|||.    .|..| . |||..|. | |..||....  .  |..|.. .|.| ||||||||||..|.|. | |.......| .|||
mltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPi

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKLKE-------TGIKAQFG
.||||||||||||||.||. ||..| |..||| ..|..||.||  |||| .||.|.|...|||. ||.||...||. ...|||.|       ||... | 
vVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFq

LLHQVTPD-PNDVHCNSAKAHATKNRSNKYLPPDKFIVAL-----KEANGYINASYLN
 |   ... ...  .   .    |||  . |. ..  | |     ||   |||||||.
rLatakeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1-170 6.3e-68 223.7 In-house 115-299 (301) alignment 
Range on Protein: 1-170
Range on HMM: 115-299/301.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSN--------------DSHTLTQYHLTSWPDHGV-PEYGTPLMIL
|||||||||||||||||||..|||||||||.||||.|||.||||||...|.||||||              .|....|...|.||..|| .|. | |...
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvi

HRQSNKSWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETE
. .  . .....||..||||..|.|.|......|.|||.|.| |||. ......|......|.||.||....| . . . . .|.
ddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-186 1e-59 197.2 In-house 119-302 (318) alignment 
Range on Protein: 1-186
Range on HMM: 119-302/318.0
MVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIqDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSW-SPSKGP
|.|...| .| |...|||.   .|...|   |.| .|  | |.|.|...|   .....| .  ||| |||||.|||| |. |. | ||..|   ....||
mltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKLKET
|.|||||||||||.|||.|| ||..| | .||. ..|..||.||  |||| |||.|..|..|||...|.||. ...  | ...|.|.
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 246-399 1.2e-58 193.6 In-house 129-284 (305) alignment 
Range on Protein: 246-399
Range on HMM: 129-284/305.0
ESCYQYWSKTD--SIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVS
. |.||| ..   . .|||. || .|.. ...|.|||..|  ...|. |  |.|.|.||||..||.... ..|..|..| ..|.|  | |..||||..|.
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvg

RSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
|.||...|.| ||..|.| |||||.|.|..|......|.||.||....|..| ...
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
0040438 (Phosphotyrosine protein) phosphatases II 1-184 3.3e-56 186.2 In-house 116-296 (317) alignment 
Range on Protein: 1-184
Range on HMM: 116-296/317.0
MVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQdGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|.|.|.|  . ||.||||.   |. ..|.|.|||..|..|.....| ..|    |...|.|.|..| |.|||||||.. ..|  . .. ... ....||.
mLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpv

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKLK
||||||||||||||||....||| ..|. ||.  .|..||.||...|||..||.||.| .|| . ...| .|  .... ..||.
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkll
subfamily_PTPRK_pd Subfamily PTPRK 1-181 6.1e-56 184.5 In-house 116-294 (314) alignment 
Range on Protein: 1-181
Range on HMM: 116-294/314.0
MVTNLKEGTKSKCEQYWPNgraESEEFGPFSVTLVDEQVLPDFVIRSITVMI-QDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGP
|.|.|.| .. || .|||.   ..| .|.. |.||. ..| ..|.|  .|   . | .. ... |.. ..||||.|| . | |. | |. .||  ...|.
mltelvevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGr

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQ
|.|||||| ||||||||||| |. ..||.|||.  .|  ||.... ||.| .||.|..| .||| .|||| ||. .. ..  
ivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyl
0046845 (Phosphotyrosine protein) phosphatases II 1-170 1.6e-55 183.9 In-house 107-280 (284) alignment 
Range on Protein: 1-170
Range on HMM: 107-280/284.0
MVTNLKEGTKSKCEQYWPNGrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWS--PSKG
|.|.| |  . ||.||||.   |. ..|.|.|||..|.| .|...| ...   . .. |.|.|..| |||||||||.. ..|. . |. ... .  |..|
mltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpggg

PILVHCSAGVGRTGTFIAIDIALEQAKRER---VVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETE
||.|||||||||||||||.|..||| ..|.   .||. ..|.|||.||. |||||.||.|.....||.. .. | 
pivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0050432 (Phosphotyrosine protein) phosphatases II 1-169 2.6e-55 183.3 In-house 138-304 (308) alignment 
Range on Protein: 1-169
Range on HMM: 138-304/308.0
MVTNLKEGTKSKCEQYWPNGRA-ESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSnDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWspSKGP
|.|.| |  . ||.||||.    .|.|.|.|.|||..|.||.|...| ....  ... .|.|.|..| |.|||||||.. ..|. . .. .||   ..||
mLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl..pggp

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGET
|.|||||||||||||||.|..||| ..|. ||. ..|..||.||. ||||..||.||....|| . . .|
ivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0051299 (Phosphotyrosine protein) phosphatases II 1-164 3e-55 183.1 In-house 122-286 (288) alignment 
Range on Protein: 1-164
Range on HMM: 122-286/288.0
MVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQD---GSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSK
|.|.| |  . ||.||||.   .|...|...|||..|.||.|...| ..|   |   |.. |.| |..| |.|||||||.. ..|. . |. .|. ....
mltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgg

GPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAI
||..|||||||||||||||.|..||| ..|..||. ..|.|||.||. ||||..||.|.....||..
gpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-186 5e-55 181.8 In-house 121-305 (319) alignment 
Range on Protein: 1-186
Range on HMM: 121-305/319.0
MVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSP-SKGP
|.|.|.|  | |...|||.  .. ||.| . ||| .|. | |..|| ... .. .  .. ...... |.||||.|||..| |. | .. .||..  ..||
mltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgP

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKLKET
| ||||||||||||||..|..||. |.| |.|.  .|.||| ||  |||. .|| |.....|||. .|.|||  ..    ...|.| 
ivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaek
subfamily_PTPRB_pd Subfamily PTPRB 1-165 5.6e-55 181.4 In-house 124-286 (293) alignment 
Range on Protein: 1-165
Range on HMM: 124-286/293.0
MVTNLKEGTKSKCEQYWPNGRaESEEFGPFSVTLVDEQVLPDFVIRSITVMIqdgSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSW--SPSKG
|.|.| |. | |||.|||. . |.  .|  .|||| |..| |.|||....     ........||| ||||||||||  ..|. . |. ...   . ||.
mltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

PILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAII
||.|||||||||||||||.|  |.. ..| .|||.||| .||..|. .||| .||.|.|..||. . 
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-244 8e-55 180.9 In-house 116-366 (515) alignment 
Range on Protein: 1-244
Range on HMM: 116-366/515.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDgsnDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|||.|||| |.|| .|||.  ..| .|| ..| ||  .   . ..| .||. .|   ||.|.||.|.| |||.|||.  . |. | ..   . .  . |.
mvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgd...dsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpl

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKLKETG-------IKAQFG
..|||||||||| .|.||  . .||  |.||.  .|. .||.|...||| .|| |....||| .   .| ||   .   .| |. .|       .  .| 
iihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefq

LLHQVTPDPNDVHCNSAKA--HATKNRSNKYLPPDKFIVALKEA-NGYINASYL
 |. ..|||   .. |...     |||  . || ..  | |    . ||||| .
tlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildspdhdyinasqm
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-170 8.9e-55 180.7 In-house 116-284 (287) alignment 
Range on Protein: 1-170
Range on HMM: 116-284/287.0
MVTNLKEGTKSKCEQYWPNGRAesEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHG-VPEYGTPLMILHRQSNKSWSPSKGP
|....|| ....| ||||....    .|.....|..|.|  ....| . |  .. ..| ....||..|.|...| |.|. | |......  .   .....
mlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgnts

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETE
|.||||..|||...|.|........|.| |.|.  .... |.|....||| .|| |. | ||| . ..|| 
ivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
0036941 (Phosphotyrosine protein) phosphatases II 1-176 1.2e-54 181.0 In-house 108-289 (297) alignment 
Range on Protein: 1-176
Range on HMM: 108-289/297.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQV--LPDFVIRSITVMIQdGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNK--SWSPS
|.|.| |  . ||.||||.   || ..|.|.|||....|  |.|...| ..|    |...|.|.|..| |.||||||||. ..|. . .. .|  . .||
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

KGPILVHCSAGVGRTGTFIAIDIALEQAK---RERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENY
.||.||||||||||.|||||.|..|.| .   .|. |||  .|. ||.||. .||||.||.||....|| . ...| .|  ..
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-183 2.6e-53 176.0 In-house 122-298 (315) alignment 
Range on Protein: 1-183
Range on HMM: 122-298/315.0
MVTNLKEGTKSKCEQYWPNGraeSEEFGPFSVTLVDEQVLPDFVIRSITVMIQDgsnDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|.||| || |.|.|.|||.       .|...||...|.|  .. .|...|. .|   . ... |.|.||||| |||.| .||| |.|. ..    | |.|
mltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgd...nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgai

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKL
.||||||||||||||..|  |.||. |...|.  .....||.|.||||...|| |..|..||...||.| |  . |.   . |
vvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-167 1.1e-52 173.7 In-house 121-286 (290) alignment 
Range on Protein: 1-167
Range on HMM: 121-286/290.0
MVTNLKEGTKSKCEQYWPNGraESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHG-VPEYGTPLMILHRQSNKSWSPSKGP
|.|| .|  | || ||||.   .....|.||..|..|..| ....| . |  .. .......|||..|.|...| |... | |...... .. . . ...
mltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgnts

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICG
|.||||..|||...|.|........| | |.|.  .....|.|....||| .|| .... ||... . 
ivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_PTPRG_pd Subfamily PTPRG 1-244 1.8e-52 173.3 In-house 121-369 (563) alignment 
Range on Protein: 1-244
Range on HMM: 121-369/563.0
MVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIR-----SITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSP
|.|||.| .. ||..|||.   |||..| ..|||..|.||    .|      . .  ..  .. .. .||| |.||||||||. .| .|  ..|...   
mitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

SKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENymstVQKLKETG--IKAQFG
  |||.||||||||||||.|..|  |.| ..| .|.. |.. ..| ||  .||| .||.||||..||||  .|||. .|.    |..||..   .. |. 
eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq....veelknctpyleqqyk

LLHQVtpDPNDVHCNSAK--AHATKNRSNkYLPPDKFIVALKEANG-----YINASYL
 . |.  .|.|.|  ||     . |||.   .| .   | |    |     |.||..|
niiqf..qpkdihiasamkqvnsiknrga.ifpiegsrvhltpkpgedgsdyvnalll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-171 5.1e-52 172.0 In-house 129-297 (298) alignment 
Range on Protein: 1-171
Range on HMM: 129-297/298.0
MVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSnDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKsWSPSKG--
|.|||.|  | |...|||.   ..|..| ..|.|  ...  |...| ..|  .. . ..... | | |||||.||||. | .. | |. .. .    |  
mltnleeldktkyhkywPd..egketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnk

PILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEI
|..|.|||||||.|||||||  ||..|.|.|||.  .|..||..|...||| .||||... ||||. ....||
pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-164 5.4e-52 171.6 In-house 120-279 (288) alignment 
Range on Protein: 1-164
Range on HMM: 120-279/288.0
MVTNLKEGTKSKCEQYWPNGRaESEEFGPFSVTLVDEQVLPDFVIRSITVMiqdGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|.|.| || |.|||.|||..  . ...| . ||||... | ||| |.. .     ...  ..|||. ..||||||||  .||. | || . . .   |||
mltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpi

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAI
.|||||||||||||||.| .... ..| ..|.||.|..||.||. .|||| ||.|.....|. |
ivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0047943 (Phosphotyrosine protein) phosphatases II 1-164 7e-52 171.9 In-house 107-272 (273) alignment 
Range on Protein: 1-164
Range on HMM: 107-272/273.0
MVTNLKEGTKSKCEQYWPNGRAE-SEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNdSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSP--SK
|.|.| |  . ||.||||.   | |...|.|.|||..|.. .|...| ...   . .. |.| |..| |.|||||||.. ..|. . .. .|  .   |.
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsn

GPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAI
||..|||||||||||||||.|..|.| ..|. ||.  .|..||.||. ||||..||.||....|| .
gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
DSPc_SM00195 1-164 1.7e-51 170.5 In-house 99-262 (263) alignment 
Range on Protein: 1-164
Range on HMM: 99-262/263.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLP-DFVIRSITVMIQDGsNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGP
|.|. .|  | ||..|||.   ..|.|| .||.||...  . ....| ...  ..  ......|||. ..|||||||.  .... | |. .|| | |.||
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAI
|.|||||||||||||..|||.|.. ..|  |||  ||..||.||..|||||.|| |.....||.|
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1-164 1.7e-51 170.5 In-house 99-262 (263) alignment 
Range on Protein: 1-164
Range on HMM: 99-262/263.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLP-DFVIRSITVMIQDGsNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGP
|.|. .|  | ||..|||.   ..|.|| .||.||...  . ....| ...  ..  ......|||. ..|||||||.  .... | |. .|| | |.||
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAI
|.|||||||||||||..|||.|.. ..|  |||  ||..||.||..|||||.|| |.....||.|
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0050432 (Phosphotyrosine protein) phosphatases II 174-399 2e-51 170.6 In-house 22-300 (308) alignment 
Range on Protein: 174-399
Range on HMM: 22-300/308.0
ENYMSTVQ--------KLKETGIKAQFGLLHQVTPdPNDVHCNSAKAHATKNRSNKYLPPDKFIVALKEANGYINASYLNES------------------
...  .|.        .|  ......|  | .|.| ...  . . ... .|||.  .|| |.  | |.| ..|||||| .                    
sslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpnt

-----------------------------CYQYWSKT---DSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDsSSWDVIQLQVTDWPQDGVVREPRTV
                             |.|||  .   .|...| ..|. .| . ...|| |.....  .|.  |  | ... |.|| .||  .|. .
vedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeil

LQVIDDVIHRQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
|. .. | ...   .|||.|||||. |.|.|... . . ||| ..|. ||||.. | .|. .||.|.|.|||  .|... .||.
ldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-185 3.2e-51 169.0 In-house 117-298 (315) alignment 
Range on Protein: 1-185
Range on HMM: 117-298/315.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSItVMiqDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|||...|| | || ||||. .|.| ||| ..|.|.. .   | |.| . |.    |..|.|.||...| |||.||..  . |. | ..   .  . . ..
mvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt..rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsl

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKLKE
|||||||||||| .|.||  ..|.||.|.||.  .|. ||..|...||| ..| |..|.||| .   .| |.  ..   .| |. 
lvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlht
Y_phosphatase Protein-tyrosine phosphatase 1-162 3.6e-51 169.2 Pfam-A 72-235 (235) alignment 
Range on Protein: 1-162
Range on HMM: 72-235/235.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLV-DEQ-VLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKG
|.|.|.|  . ||.||||. . ||...| ..|.|. .|.    ....| ...  ...........|.|.|.||||||||  ..|. | |. .|| ....|
mltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksg

PILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
|..|||||||||||||.|.||.|||...|. ||.  ||..||.||..|||.|.||.||....||
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1-162 3.6e-51 169.2 In-house 72-235 (235) alignment 
Range on Protein: 1-162
Range on HMM: 72-235/235.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLV-DEQ-VLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKG
|.|.|.|  . ||.||||. . ||...| ..|.|. .|.    ....| ...  ...........|.|.|.||||||||  ..|. | |. .|| ....|
mltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksg

PILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
|..|||||||||||||.|.||.|||...|. ||.  ||..||.||..|||.|.||.||....||
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0045450 (Phosphotyrosine protein) phosphatases II 1-165 5.3e-51 169.5 In-house 137-305 (307) alignment 
Range on Protein: 1-165
Range on HMM: 137-305/307.0
MVTNLKEGTKSKCEQYWPNGrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNK--SWSPSKG
|.|.|.| .. || ||||.   |. ..|.| |||..|..|.....| ..|   ||.. |.|.|..| |.|||||||..  .|  . .. .|  ...|..|
mltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkgg

PILVHCSAGVGRTGTFIAIDIALEQAKRERV---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAII
|.||||||||||||||||....|.| ..| .   ||.  .|..||.||...||...||.||.. .|| . 
pvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 246-399 2.7e-50 165.9 In-house 131-284 (290) alignment 
Range on Protein: 246-399
Range on HMM: 131-284/290.0
ESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
. |.|||...|. ..||. .. .. . .|.|.|||....... . ..  |.|.|.| |...| | .| |.|.||  ... | | | ...||||||||.||
vkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrs

GVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.|.|.. .....|| | |.||||| |  |  ||| |.| .||  |....  ||.
avfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
0039614 (Phosphotyrosine protein) phosphatases II 1-168 3.2e-50 166.6 In-house 131-293 (297) alignment 
Range on Protein: 1-168
Range on HMM: 131-293/297.0
MVTNLKEGTKsKCEQYWPNGRAeseEFGPFSVTLVDEQVLPDFVIRSITVMIqdgSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNK--SWSPSKG
|.|.|.|  . ||.||||.      ..|.|.|||.....|.....| ..|     .. |.|.|... |.|||||||.. . |. . .. ..  ...|..|
mLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkgg

PILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGE
|.||||||||||||||||....||| ..|. ||.  .|..||.||...|||..||.||.| .|| . .. 
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0051299 (Phosphotyrosine protein) phosphatases II 168-398 3.6e-50 166.4 In-house 2-286 (288) alignment 
Range on Protein: 168-398
Range on HMM: 2-286/288.0
ETEIPTENYMSTVQKL---KETGIKAQFGLLHQVTPDpNDVHCNSAKAHATKNRSNKYLPPDKFIVALK-----EANGYINASYLN--------------
.|||..|.....|.||     ||....|  | ...|| ..... . ... .|||.  .|| |.  | |.     | ..||||||..              
dteisveellklvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgP

-------------------------------ESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDK---DDSSSWDVIQLQVTDWPQDGVVRE
                               | |.|||.  .|...|...|. .| . ...|| |.....  .    |. |  |.....|.|| .||   
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

PRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
|. .|. . .|.. ..  ||||||||||. |.|.|... . . ||| ..| .|||... | .|. .||.|.|.|||  .|... .||
pellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 1-186 7e-50 164.8 In-house 131-317 (330) alignment 
Range on Protein: 1-186
Range on HMM: 131-317/330.0
MVTNLKEGTKSKCEQYWPNGRaeSEEFGPFSVTLVDEQVLPDFVIRSITVM-IQDGS--NDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSK
|.|.|||  ..||.||||.    .  .|   |.. ||.|| |. .| . |  . |..  ..|  ..|.|.||||| |||  .  .. | .. .|    | 
mltelkerkeekcaqywPdeG..lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsa

GPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKLKET
||| ||||||||||||||..|  ||. | ||.||. ..|.|||.|| .||||. ||.|.. ..||  . |.||.      . .|||...
gpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynk
0043336 (Phosphotyrosine protein) phosphatases II 1-162 1.3e-49 164.5 In-house 118-275 (278) alignment 
Range on Protein: 1-162
Range on HMM: 118-275/278.0
MVTNLKEGTKSKCEQYWPngrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIqDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|.|.|.|  . || ||||    .|...|.|.|||..|..|.|...| ..|    |.. |.| |.|| ..||||||||  ..|. . .. ..  ..|.||.
mLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
||||||||||||||||....|||...|. ||.  .|..||.||...|||..||.||.. .||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 246-400 9.8e-49 160.9 In-house 126-280 (287) alignment 
Range on Protein: 246-400
Range on HMM: 126-280/287.0
ESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
| |||||....|. .||| .| ....  .||.|||.... .. ...   | | |.|.|.. | | ||.|.| ||.. .. |.| | ...|||||||| ||
evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

GVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
...|.. .....|| | |.||||| |  |  |||.| | |||. |.|.. .||. 
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
0046845 (Phosphotyrosine protein) phosphatases II 187-399 2.2e-48 160.5 In-house 1-275 (284) alignment 
Range on Protein: 187-399
Range on HMM: 1-275/284.0
GIKAQFGLLHQVTPDPN-DVHCNSAKAHATKNRSNKYLPPDKFIVALK------EANGYINASYLNES--------------------------------
|....|  | ..|...  ....  .... .|||.  .|| |.  | ||      | ..||||||..                                  
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

------------------CYQYWSKTD-SIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK
                  |.|||. .. ....|...|. .| . ...|| |.. ..  . .. |  |.....|.|| .||  .|. .|. ...| . ...
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEC---VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
  ||||.|||||. |.|.|... . . ||| ..|    .|||... | .|. .||.|.|||||  .|... .||.
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
subfamily_Ptp69D_pd Subfamily Ptp69D 1-183 9.1e-48 157.9 In-house 121-305 (307) alignment 
Range on Protein: 1-183
Range on HMM: 121-305/307.0
MVTNLKEGTKSKCEQYWPNGraESEEFGPFSVTLVDEQVLPDFVIRSITVMIQD--G--SNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPS
|..||.| .. ||..|||.   .  ..|   |.||.|.  .|..||.. |  ..  .   .||. ..||| |.|.|  |||  . |. | .| ..  . .
mlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln

KGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKL
..||.|||||||||.|.|.|.|. |.| | |  |||  .|  ||.||  .|| |.|||||.  .|. .  |.|..  ... .....|
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
subfamily_PTPN12_pd Subfamily PTPN12 1-164 1.6e-47 156.8 In-house 113-277 (290) alignment 
Range on Protein: 1-164
Range on HMM: 113-277/290.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLP-DFVIRSITVMIQdgsNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGP
|. .. |  | |||.|||.   |. |||.|.||| .|. .  ||.||...|  |   ..|....|.| |.|||||||.  ..|. | .. ..  . .. |
maCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaP

ILVHCSAGVGRTGTFIAIDIALEQAKRERV---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAI
..|||||||||||| ||||.. |. |.|..   .|.  .| .||.||  .||| .||.... .|.| .
lvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0040439 (Phosphotyrosine protein) phosphatases II 1-164 1.9e-47 157.3 In-house 84-246 (249) alignment 
Range on Protein: 1-164
Range on HMM: 84-246/249.0
MVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQdGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNK--SWSPSKG
|.|.|.|  . ||.||||.   .| |.| |.|||....|..|...| ...    . ..|.| .... |.|||||||..  .|. . .. .|  .. |..|
mLtslvelgrekcaqywpl..ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkgg

PILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAI
|.||||||||||||||||....||| ..|. ||.  .|. ||.||...||...||.||.. .|| .
pvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 1-167 3e-47 156.7 In-house 94-275 (278) alignment 
Range on Protein: 1-167
Range on HMM: 94-275/278.0
MVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQ---DGSNDSHTLTQYHLTSWPDHGVPEYG--TPLMILHRQSNKSWS-
|.|.|.|... ||.||||.   .|...|.|.|||..|.||.|...| ..|      . .. |...|..|...|||||||..   ...  | .. ..  . 
mltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

------------PSKGPILVHCSAGVGRTGTFIAIDIALEQAkrERVVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDTVLEAIICG
            .|.||.|||||||||||||..|... ||.   |..||.  .|. ||.||.  .||.|.||.||.. .|| . .|
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-167 3.9e-47 155.6 In-house 82-245 (250) alignment 
Range on Protein: 1-167
Range on HMM: 82-245/250.0
MVTNLKEGTKSkCEQYWPNGraESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDgSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSP-SKGP
|.|||||  |  ..||||    ..|..|   |.| ....  |...| . .  .   .|. .. |.| ..||| ||||. |  . | .. ..|     ..|
mLtnLkesekt.yhqywPve..kaekyGdvtvsllskeefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaP

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICG
..|.|||||||.|.|||||  ||..|.|.|||.  ....||..|...|..|.||||..  .|.|. . 
vivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
0042113 (Phosphotyrosine protein) phosphatases II 1-162 4.7e-47 155.8 In-house 82-241 (245) alignment 
Range on Protein: 1-162
Range on HMM: 82-241/245.0
MVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIqDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWS-PSKGP
|.|.. |  . ||.||||.   || ..| |.|||..|..|.|...| ..|   .|.. |.. ..|| ..|||||||..   |  ...  .|  . .|.||
mLteeeelgrvkcaqywpl..gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngp

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
.||||||||||||||||....|||...|. |..  .| .||.||...|||..||.||.. .||
vlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 1-162 5e-47 155.9 In-house 78-240 (243) alignment 
Range on Protein: 1-162
Range on HMM: 78-240/243.0
MVTNLKEGTKSKCEQYWPngraESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKS--------
|.|.|.| .. ||.||||    .....|.|.|||..|..|.|...| ....  | .. ... ..|| ..|||||||.  ..|. .... ..         
mltelvElgrekcaqywp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll

WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAkreRvVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDTVLE
  .|.||.|||||||||||||.||... |..    . ||.  .|..||.||.  .|||..||.||.. .||
aldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 9-183 8.6e-47 155.0 In-house 136-310 (319) alignment 
Range on Protein: 9-183
Range on HMM: 136-310/319.0
TKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLpdFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQ--SNKSWSPSKGPILVHCSA
|| || ||||.   . || .  .|..|.|     .|.|.| .  .   .|   .||.|.  |||.|||.|...|| | ..    .|    . .|.|||||
tkdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsa

GVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKL
||||||..|..|. |.. |.|. ||.  .|. ||||| ..|| | || |.. ..||  . | ...   .. . ...|
GvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 58-393 3.7e-46 152.3 In-house 87-433 (440) alignment 
Range on Protein: 58-393
Range on HMM: 87-433/440.0
DSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWS-PSKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFL
.|.|| |||  .|||.|||..  |.. . .. |.|    ..||.|||||||.||||  ||.|  | .|||   .||  ..| .|..| .|||| .||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDTVLEAIICGETEIPTENYMSTVQKLKETGIKAQFGLLHQVTPDpndvHCNSAKAHATKNRSNKYLPPDKFIVALKEANGYINASYLNE-SCYQYWS-K
|..|||...||.| |  ..    |....    ...   |.|        . .     ||.   .  .     .|   .    |    ||. .|  ||  .
heavlegllcgdtliledditerveqiqwpnphtdksplqqefeg....yskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvn

TDSIKFGEYFVESTSHHDFNGYTERKFHIRSdkdDSSSWDVIQLQVTDWP----QDGVVREPR---TVLQVIDDV----IHR---QQKIGG-GPVVVHCS
| |. || . |      ..|    | . ..         .. |..|  ||     |||  . .   .|||..| .    | |   | . |   |..||| 
trsvtfgpftvghkgsenmnrvkvrtlelky...keevheirqfevqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhcl

DTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
  .  |||.|.|   ||| . .  .||||  . .| |.|  | || .|   | .
sgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 9-183 5.3e-46 152.4 In-house 100-274 (284) alignment 
Range on Protein: 9-183
Range on HMM: 100-274/284.0
TKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLpdFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQ--SNKSWSPSKGPILVHCSA
|| || ||||.   . || .  .|..|.|     .|.|.| .  .   .|  ...|.|.  |||.|||.|...|| | ..    .|    . .|.|||||
tkdkcsqywplkivikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

GVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKL
||||||..|..|. |.. |.|. ||.  .|. ||||| ..|| | || |.. ..||  . | ...   .. . ...|
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
0036941 (Phosphotyrosine protein) phosphatases II 179-399 1.9e-45 150.8 In-house 6-278 (297) alignment 
Range on Protein: 179-399
Range on HMM: 6-278/297.0
TVQKLKETGIKAQFGLLHQVTPdPNDVHCNSAKAHATKNRSNKYLPPDKFIVALkEANG--YINASYLN-------------------------------
  ..|  .... .|  | .. . . .  . . ... .|||.  .|| |.  | | . .|  ||||||..                               
lekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

--------------ESCYQYWSKT--DSIKFGEYFVESTSHHD--FNGYTERKFHIRSDkDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ
              | |.|||. .  .|...|...|. .| .   ...|| |....    ... |  | ....|.|| .||   |...|. |. | ....
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

KI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.. .||||.||||. |.|||... . . |.| .    |. ||.... | .|. .||||.|||||  .|... ..|.
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0040438 (Phosphotyrosine protein) phosphatases II 181-400 2.4e-45 150.5 In-house 13-278 (317) alignment 
Range on Protein: 181-400
Range on HMM: 13-278/317.0
QKLKETGIKAQFGLLHQVTPDpnDVHCNSAKAHATKNRSNKYLPPDKFIVALKEAN-----GYINASYLNES----------------------------
 |.  |... .|  | ....|  .  . . ...  |||.  .|| |   | |.  .     .|||||| .                              
lksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqg

-----------------CYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDkDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiG
                 |.|||.  .....|...|. .| .  .|.| |....  . .|| |  | ... |.|| .||   |...|. .. | . ..  .
vtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..d

-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
 ||||.||||. |.|.|... . . |||.. |. |||... | .|. .||||.|.|||  .||.. .||. 
pggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
0047943 (Phosphotyrosine protein) phosphatases II 181-398 2.5e-45 150.5 In-house 7-272 (273) alignment 
Range on Protein: 181-398
Range on HMM: 7-272/273.0
QKLKETGIKAQFGLLHQVTPdPNDVHCNSAKAHATKNRSNKYLPPDKFIVAL-KEANGYINASYLNE---------------------------------
..|  |.....| || ...| . .  . . ... .|||.  .|| |.  | |  . ..||||||..                                  
kllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

------------SCYQYWSKTD---SIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSsSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-G
             |.|||. .    |...|...|. .|.. ...|| |.. ... ...  |  |.....|.|| .||   .  .|. |..| . .... .
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealps

GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
.||||||||. |.|.|... . . |.| ..|  |||... | .|. .||.|.|.|||  .|... .||
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-186 3.8e-45 149.4 In-house 120-310 (325) alignment 
Range on Protein: 1-186
Range on HMM: 120-310/325.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGsNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSN------KSWS
.|.|  .. | .| .|||.  ..| .||.. | |.  . . |.| | . |   ..  .. .. |..| ||.| ||... . |. . .  .      .. .
vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk.GetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtant

PSKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKLKET
 . .||||||||||||||.||..  ||..   |  ||| | |..||..| .||.| |||....... ||...|.|..|  .. . .  |.| 
kastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqer
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1-163 1e-44 147.5 In-house 81-239 (239) alignment 
Range on Protein: 1-163
Range on HMM: 81-239/239.0
MVTNLKEGTKSKCEQYWPNGRAeseEFGPFSVTLVDEQVLPDFVIRSItVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|.| | || | || ||||.  .   ..  . |||   .|. |..||.. || | |  . . . |||.| |||.|||.| | .. |.|.  |   |   | 
mltglieghkkkchqywpdsts...kycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpw

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEA
..||||||||||.|. ||  | |||... |||   |. .|..| .|||| .||||.| .||||
vihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
0039614 (Phosphotyrosine protein) phosphatases II 181-400 1.5e-44 148.1 In-house 27-291 (297) alignment 
Range on Protein: 181-400
Range on HMM: 27-291/297.0
QKLKETGIKAQFGLLHQVTPDpndVHCNSAKAHATKNRSNKYLPPDKFIVALKEANG------YINASYLNES---------------------------
.... |.....|  | ...||     .   ... .|||.  .|| |   | ||  .|      ||||||..                             
kansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

------------------CYQYWSKTDSiKFGEYFVESTSHHDFNGYTERKFHIRSdkdDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI
                  |.|||. . . ..|...|. .. .  .||| |.....    .. |  | ..|.|.|| .||   ....|.... | ..... 
qgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealael

-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
 .||||.||||. |.|.|...   . |||.. |. |||... | .|. .||||.|..||  .||.. ..|. 
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0043336 (Phosphotyrosine protein) phosphatases II 174-398 2.3e-44 147.3 In-house 8-277 (278) alignment 
Range on Protein: 174-398
Range on HMM: 8-277/278.0
ENYMSTVQKLKETGIKAQFGLLHQVTPdpNDVHCNSAKAHATKNRSNKYLPPDKFIVALKE-----ANGYINASYLNES---------------------
.... .. .   |.....|  |.....  ..  .   ... .|||.  .|| |   | |.       ..||||||..                       
lkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

------------------------CYQYWSkTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSsWDVIQLQVTDWPQDGVVREPRTVLQVIDDVI
                        |.|||.  .|...|...|. .. . ...|| |....   .|. |   | ... ..|| .||   . ..|. . .|.
rmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavr

HRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
....   .|||.||||. |.|.|... . . ||| . |. ||.... | .|. .||||.|..||  .|... .||
eale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1-162 4e-44 145.5 In-house 82-239 (239) alignment 
Range on Protein: 1-162
Range on HMM: 82-239/239.0
MVTNLKEGTKSKCEQYWPNGRAeseEFGPFSVTLVDEQVLPDFVIRSItVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|.| | || | || ||||.  .   ..  . |||   .|. |..||.. || | |  . . . |||.| |||.|||.| | .. |.|.  |   |   | 
mltglieghkkkchqywpdsts...kycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpw

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
..||||||||||.|. ||  | |||... |||   |. .|..| .|||| .||||.| .|||
vihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1-180 6.5e-44 144.9 In-house 105-282 (283) alignment 
Range on Protein: 1-180
Range on HMM: 105-282/283.0
MVTNLKEGTKSKCEQYWPNgrAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|.|.|.|. . || ||||.    ||..|.| ||| .|     |.|. ...  .  ....  |. | .  | . |       |. . .   .     ||||
mltklqedlrikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPi

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTV
.||||.|.|||..|||.  ....|. | |||.  .|. .|.||| .||||||| ..|. |||  .||.|.|   . .||.
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqsti
subfamily_PTPN6_pd Subfamily PTPN6 1-162 4e-43 142.5 In-house 128-295 (306) alignment 
Range on Protein: 1-162
Range on HMM: 128-295/306.0
MVTNLKEGTKSKCEQYWPNGRAESEeFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLM----ILHRQSNKSWSPS
|.|.  | .|.|| .|||.  ...| .|  ||| |.|. | |...|...|  .. ....... ||| .||||||||.    ..     ..|..... . .
mttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeae

KGPILVHCSAGVGRTGTFIAIDIALEQAKRER---VVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
.|||.||||||.||||||| ||| |.. ...     .||  .|. .|.||  .||| .|| |.. .. .
agpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
0045450 (Phosphotyrosine protein) phosphatases II 185-398 4.7e-43 143.4 In-house 26-304 (307) alignment 
Range on Protein: 185-398
Range on HMM: 26-304/307.0
ETGIKAQFGLLHQVTPD-PNDVHCNSAKAHATKNRSNKYLPPDKFIVALK------EANGYINASYL---------------------------------
 ||....|  | .||.. ...  . . ... .|||.  .|| |   | |.      | ..||||||                                  
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

--------------------NESCYQYWSKTDSI-KFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVI
                    .| |.|||. ...   .|...|. .| .  .||| |....   . .. |  |.... |.|| .||   . ..|. |. | 
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

HRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
. ...  .||||.||||. |.|.|...   . |.| ..|..   ||.... | .|. .||||...|||  .|... ..|
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-164 1.6e-42 140.5 In-house 114-276 (281) alignment 
Range on Protein: 1-164
Range on HMM: 114-276/281.0
MVTNLKEGTKSKCEQYWPNGRAeSEEFGPFSVTLVDEQVLPDFVIRSITVmiQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSK-GP
|||.  |. | || .|||.... . ..| . |. . |.  . .. | ...  .  |... ...| . |.|||||||.  . |.  ... .|  ....  |
mvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkap

ILVHCSAGVGRTGTFIAIDIALEQAKRE-RVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAI
...|||||||||||.||.| .......| . .|.  .|. ||..|. ||||. || |.. .||.|.
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1-161 1.7e-42 140.4 In-house 103-265 (274) alignment 
Range on Protein: 1-161
Range on HMM: 103-265/274.0
MVTNLKEGTKSKCEQYWPNGRAE--SEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGsndSHTLTQYHLTSWPDHGVPEYGTPLMILHR--QSNKSWSPS
|.|.|||  ..||..|.|. .    ||..| .... ..     |. .|....  .     ..... |  |.|||| .|.  ..|. | .  ..... .  
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeena

K-GPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVL
| .|..||||||.|||| ||||.||. | ..| |||. .||  ||..|  |||| .|| ..| .. 
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_PTPN13_pd Subfamily PTPN13 1-164 2.2e-42 140.2 In-house 107-269 (273) alignment 
Range on Protein: 1-164
Range on HMM: 107-269/273.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGP-FSVTLVDEQVLPDFVIRSITVMiQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSpSKGP
|||. ||. | ||..|||. . ..      . |.|.. | | .||.|...|  .  |..|. ... ....|||||||   ..|. . .. ..  . ..||
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk.dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagP

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAI
|.||||||.||.||.|.||..|.  .|.. .|.  ||..||.||  .||| |||.| . ..||..
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-175 9.5e-42 138.1 In-house 122-295 (297) alignment 
Range on Protein: 1-175
Range on HMM: 122-295/297.0
MVTNLKEGTKsKCEQYWPNGRAESeeFGPFSVTLVDEQVLPDFVIRSITVMiQDGSNDSHTLTQYHLTSWPDHGVPE--YGTPLMILHRQSNKSWSPSK-
|.....|..| || .||..    .  ||  ||.|   .    |. |...|  .. .   . . ||. ..|||. |..    . |. |  . .|..|  . 
mlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevt.kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnae

GPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTEN
||.||||.||||||| ...||  . .||||  ||| |.|..|||.|...||| .|| |.. .||||... .|.|... 
gPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy
subfamily_PTPN9_pd Subfamily PTPN9 1-162 1.1e-41 137.8 In-house 115-288 (297) alignment 
Range on Protein: 1-162
Range on HMM: 115-288/297.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDgSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHR-----QSN-----
|.| . |  . || ||||... .|.||| .||. |. ..  |...|....   .  ..| ..| . ..||||.|||. .. |. . .     |.      
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkel

---KSWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
   .   ||. ||.||||||.|||||||..||.|.. ... .||.   |..||.||  ..|| .||.| . .|||
gdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0040439 (Phosphotyrosine protein) phosphatases II 204-398 1.7e-41 137.9 In-house 2-246 (249) alignment 
Range on Protein: 204-398
Range on HMM: 2-246/249.0
DVHCNSAKAHATKNRSNKYLPPDKFIVALKE-----ANGYINASYLN---------------------------------------------ESCYQYWS
.. . . ...  |||.  .||.|   | |.       ..||||||..                                             | |.|||.
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

KTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDkDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVS
  .|...|...|. .| . ...|| |....     |..|  | ..|.|||| .||   . ..|. |. | . ....  ||||.||||. |.|.|...   
lggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

IGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
. ||| . |. ||.... | .|. .||||...|||  .|... ..|
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0051429 (Phosphotyrosine protein) phosphatases II 1-185 2.5e-41 137.5 In-house 51-245 (272) alignment 
Range on Protein: 1-185
Range on HMM: 51-245/272.0
MVTNLKEGTKSKCEQYWP----------NGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGtPLMILHRQSN
..... |  . ||..|||          .  |.. ..| ..|||. |..|.|...| ...... . .........| |.|||||||.    | .|.   .
dLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld

kswspsKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVD--------IAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAiICGETEIPTENYMSTVQK
      .||.|||||||..||||..|... |..  .| .||        ....|..||.||...||| .||.||.. .||. ... .... | ...... 
......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaalda

LKE
..|
ide
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1-162 4.1e-41 135.8 In-house 75-237 (237) alignment 
Range on Protein: 1-162
Range on HMM: 75-237/237.0
MVTNLKEGTKSKCEQYWPNGRaESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQ-SNKSWS-PSKG
|.| | || . || .|||.   . . .| ..|.|  .. . |. .||.... .   ..   . ||..|||||.|||.. . |. . ..  |.|   .  |
mltgliegnelkchkywpstd.qpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesg

PILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
| ..|||||||||| |. ||  | ||| ..||||   |  . ..|  ..|| |||||.|.|.||
pwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN3_pd Subfamily PTPN3 1-163 1.5e-40 133.9 In-house 114-274 (280) alignment 
Range on Protein: 1-163
Range on HMM: 114-274/280.0
MVTNLKEGTKSKCEQYWPNgRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQdGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|.|.| |  . || ||||.   .. |.| |||..  |.    .|.| .... .  ........|   ..|||||||.  . .. . .. .|  | .. |.
mlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdk.etkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePv

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEA
.||||||.|||| .|....||    ... | .  || ..|.||. .||| .|| |. ...|..
vvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-176 5.1e-40 132.3 In-house 121-291 (439) alignment 
Range on Protein: 1-176
Range on HMM: 121-291/439.0
MVTNLKEGTKskceqYWPNGraESEEFGPFSVTLVDEQVLPDFVIRSITVMI-QDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKS-WSPSKG
|.||| |  |     |||    .   .|  .|    .  ||..||| . |.  .| ..  .|. |.| ..|||. ||   . .. . |  | .  .   |
mltnlvesyk.....ywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeyg

PILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENY
|..|||||||||||| ||.|||||| | |  ||| |||. ||.|| .|||.| ||||....||| |. |.. .  ...
pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_PTPRD_pd Subfamily PTPRD 246-400 1.2e-39 131.4 In-house 131-283 (564) alignment 
Range on Protein: 246-400
Range on HMM: 131-283/564.0
ESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIrSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRS
. | .|| .... ..||. |. ....... |. |.| . ..|..|.|  | | . |.||. ||  .....|..|..| . . . . ||.|||||  | |.
vkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRT

GVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
|... ... ||. |.| .||..|. ||.|. ..  | | |||  |...|  .|..
GtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
0042113 (Phosphotyrosine protein) phosphatases II 207-398 4.8e-39 129.6 In-house 3-243 (245) alignment 
Range on Protein: 207-398
Range on HMM: 3-243/245.0
CNSAKAHATKNRSNKYLPPDKFIVALKEANG-----YINASYL---------------------------------------------NESCYQYWSKTD
. . ... .|||.  .|| |   | |.. .|     ||||||                                               . |.|||.  .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

SIKFGEYFVESTSHHDFNGYTERKFHIRSdKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLE
|...|...|. .| . ...|| |....   . |. |  ||... ..|| .||   ....|.... | . ... ..|||.||||. |.|.|... . . ||
sltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

QCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
| ..|. |..... | .|. .||||.|..||  .|... ..|
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 247-400 8.8e-39 128.5 In-house 140-292 (298) alignment 
Range on Protein: 247-400
Range on HMM: 140-292/298.0
SCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDsSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 . .|| .. . ..||  |.  |...|  .. ||... . | . ..  | ||..| ||. || .. ..||.....|   ||. |  ||.|.||. | |||
kyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsG

VYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
 .. ..  ||. |.| ||||||| |..|...||||.| |||. ||...  .|. 
tfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1-162 1.9e-38 127.0 In-house 94-262 (270) alignment 
Range on Protein: 1-162
Range on HMM: 94-262/270.0
MVTNLKEGTKSKCEQYWPNGRAE--SEEFGPFSVTLVDEQVLPDFVIRSITVMiQDGSndSHTLTQYHLTSWPDHGVPEYGT------PLM-ILHRQSNK
|.|.|.|  ..|||.|||. . |  . |.|  .|. . |.    .... ...  ..|.  .. |. .. ..|||||||.          |. .|.   . 
mttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrs

SWSPSKG-PILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
. . .|. |.|||||||||||||.||.|||..  .... ||.. |...||..||..||. .|| ||. .|.|
ekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
0045098 (Phosphotyrosine protein) phosphatases II 196-400 6.6e-38 126.1 In-house 16-274 (278) alignment 
Range on Protein: 196-400
Range on HMM: 16-274/278.0
HQVTPDPNDVHCNSAKAHATKNRSNKYLPPDKFIVAlkeanGYINASYL-------------------------------------------NESCYQYW
  ....|... ..    .. |||   .|| |   |      .||||||.                                           .| |.|||
llllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

SKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSD---KDDSSSWDVIQLQVTDWPQDGVVREP--RTVLQVIDDVIHRQQK------------IGGGPVV
   .|. .|...|. .| . .. || |.....     . |  |. | .|. . ||  ||  .|  . .|.... . .....             .||||.
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSDTVSRSGVYCSVSIGLEQCkaECVVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVIDMYLQM
||||  |.|.|... . . ||..  |..||.... | .|. .|| ||..||||  .|... ..|..
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 246-399 1.7e-37 124.0 In-house 91-243 (250) alignment 
Range on Protein: 246-399
Range on HMM: 91-243/250.0
ESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDdSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
. . |||    . |.|.  |.  |.. |  || ||. . . |  ...  | ||. . ||  || .. ..||.....|   ||..| .||.|.||  |.||
ktyhqywPvekaekyGdvtvsllskeefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrs

GVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
| .. ..  ||. | | |||||.| |..|. .|.||..|||| ..| .|  .|.
Gafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 247-399 1.3e-36 121.3 In-house 130-281 (318) alignment 
Range on Protein: 247-399
Range on HMM: 130-281/318.0
SCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSdKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSG
 . .|| . .|...|.  || ... ... |. |.|...  .. ..| .| | ..|.||. ||  .. ..|... .| . ||| | ||.|||||  | | |
kvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtG

VYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
|.. |.| ||. ||| .|||||. | .|. ..  | | .||. ||||.  .|.
vfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_PTPRN_pd Subfamily PTPRN 2-163 7.9e-36 118.3 In-house 131-291 (297) alignment 
Range on Protein: 2-163
Range on HMM: 131-291/297.0
VTNLKEGTKSKCEQYWPNGRaeSEEFGPFSVTLVDEQVL-PDFVIRSITVMIQDgSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
.|.|.|   ..|..|||.    || .. . | || | .   |...||. .   . .... |.||.|  |||..|||    .|. . |. |||.     ||
ltrleeegvkqckrywpdeG..sevyhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpi

LVHCSAGVGRTGTFIAIDIALEQAK-RERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEA
.||||.|.||||..|.||. |.. .   . .|||  .. ||.|| ..|.| ||. |   .| | 
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
PTPc_DSPc_SM00012 62-162 8.5e-36 117.7 In-house 2-105 (105) alignment 
Range on Protein: 62-162
Range on HMM: 2-105/105.0
LTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSK--GPILVHCSAGVGRTGTFIAIDIALEQAKRE-RVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
...|| |.||||||||...... | |. .|. . |.  .|..|||||||||||||.|.||.|.| ..| . |||  ||..||.||..||||..||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TVLE
 .||
alle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 248-400 9.6e-36 118.4 In-house 133-285 (319) alignment 
Range on Protein: 248-400
Range on HMM: 133-285/319.0
CYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGV
. .||....  ..|.. |.  ...  ..|  ||....  ...  . .| . | |.||...| .. ...|... .. . ..|   ||.|||||. | | | 
lkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGt

YCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
.. ... ||. | | |.|||.. . .|  ..  | . |||. ||...  ....
fivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
Y_phosphatase Protein-tyrosine phosphatase 246-394 1.9e-35 117.8 Pfam-A 82-233 (235) alignment 
Range on Protein: 246-394
Range on HMM: 82-233/235.0
ESCYQYWS--KTDSIKFGEYFVEST-SHH-DFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDT
| | |||.  . .| ..|...|| . . . | ..|| ||......|..| .  | ||..|.||. || ..|. .|..|..| ... .   ||||||||. 
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaG

VSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|.|.|......| |||..||  |||.|. | .|...||.|..||||  .|..|
vgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 246-394 1.9e-35 117.8 In-house 82-233 (235) alignment 
Range on Protein: 246-394
Range on HMM: 82-233/235.0
ESCYQYWS--KTDSIKFGEYFVEST-SHH-DFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDT
| | |||.  . .| ..|...|| . . . | ..|| ||......|..| .  | ||..|.||. || ..|. .|..|..| ... .   ||||||||. 
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaG

VSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|.|.|......| |||..||  |||.|. | .|...||.|..||||  .|..|
vgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0037934 (Phosphotyrosine protein) phosphatases II 206-397 2.3e-35 117.7 In-house 3-241 (243) alignment 
Range on Protein: 206-397
Range on HMM: 3-241/243.0
HCNSAKAHATKNRSNKYLPPDKFIVALKEaNGYINASYL----------------------------------------------NESCYQYWSktDSIK
.. . ... .|||   .|| |   | |.  ..||||..                                                | |.|||.  ... 
siallpenlsknrysdilpydhsrvkleg.sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevt

FGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYCSVS
.|...|. .| . ...|| |.....  . |  .. ||... . ||  ||  .|  .|. .|.|.  ...        .||||.||||  |.|.|...   
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaay

IGLEQCkaeCvVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVIDMY
. |...   . ||.... | .|. .|| ||.|..||  .|... ..
lmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
DSPc_SM00195 246-398 2.2e-34 114.3 In-house 109-262 (263) alignment 
Range on Protein: 246-398
Range on HMM: 109-262/263.0
ESCYQYWSKT--DSIKFGEYFVESTSHHDFN-GYTERKFHIRSDKDdSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTV
| |..|| ..  .. .||.. |. .. .  .  .. |..... ... . . .| |.|...||. ||  ... ||...  | ......  ||.|||||. |
ekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGv

SRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
gRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 246-398 2.2e-34 114.3 In-house 109-262 (263) alignment 
Range on Protein: 246-398
Range on HMM: 109-262/263.0
ESCYQYWSKT--DSIKFGEYFVESTSHHDFN-GYTERKFHIRSDKDdSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTV
| |..|| ..  .. .||.. |. .. .  .  .. |..... ... . . .| |.|...||. ||  ... ||...  | ......  ||.|||||. |
ekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGv

SRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..|  |.
gRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN23_pd Subfamily PTPN23 1-163 4.4e-34 112.6 In-house 113-279 (288) alignment 
Range on Protein: 1-163
Range on HMM: 113-279/288.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSnDSHTLTQYHLTSWPDHGVPEYGTPL-MILHRQS---NKSWSPS
|... .|  | |...|||. . |...||..|||| ... .. .| | ... ..| .   ....  .|||||..|||.    |  .|.      ..   .|
mllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrks

KGPILVHCSAGVGRTGTFIAIDIALEQ-AKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEA
| |..|||||||||||.|  .  |...  |.. ..||  .|.|||.||  |||. .|. |. . ||||
ktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0036282 (Phosphotyrosine protein) phosphatases II 1-158 1.3e-32 108.3 In-house 42-164 (174) alignment 
Range on Protein: 1-158
Range on HMM: 42-164/174.0
MVTNLKEGTKSKCEQYWPNgraeseefgpfsvtlvdeqvlpdfvirsitvmiqDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|....||  . || .|||                                   . .  ...  ||. . |||||||.  . | .. .  .   ....||.
mlleekelglykcinywpe..................................lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

LVHCSAGVGRTGTFIAIDIALEQAKrERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
|||||||||||||..|... | . . |..||.  .| .||.||..|||| .|| ||..
lVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_CG7180_pd Subfamily CG7180 4-169 1.3e-32 107.7 In-house 118-295 (296) alignment 
Range on Protein: 4-169
Range on HMM: 118-295/296.0
NLKEGTKsKCEQYWPNGRaeSEEFGPFSVTLVDEQVLPDFVIRSITVMIQ---------DGSNDSHTLTQYHLTSWPD-HGVPEYGTPLMILHRQSN---
.  . .| .. .||||     |..|.. | .| |. .....|| . .. .         . . .  ......|| |.  . ||   . |. | |. .   
ktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr

KS--WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGET
.     | .||..|..| |..|.| ..|||..||....|  ||. . | .||..| ..|.. ..| .. |..|||..|. .
ekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_PTPRA_pd Subfamily PTPRA 246-397 3.7e-32 106.5 In-house 141-294 (330) alignment 
Range on Protein: 246-397
Range on HMM: 141-294/330.0
ESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKD---DSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTV
| |.||| .  .. .|.  ||   .   . || ||| ..   |   . .|  | |.  | ||. ||  ||. .|...  | . .|. .| |.|||||  |
ekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGv

SRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
 |.| .. ..  ||. ||| .||||.. | .|  .|  | |.|||. || |.  |
GrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPN14_pd Subfamily PTPN14 1-163 1.3e-31 104.7 In-house 123-295 (300) alignment 
Range on Protein: 1-163
Range on HMM: 123-295/300.0
MVTNLKEGTKSKCEQYWPNG--RAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQdGSNDSHTLTQYHLTSWPDHGVPEYGTP-------LMILHRQSNK
|.|. .|. | |. .|.|.   .... ||| | ||    .  . .. .....     |..  |.     | ||||||||  ..       .  . |..|.
mlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl.pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktns

SWS--PSKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEA
. .   || |.||||||||||||  |  |. ..  . ....||  ...|||.||| .|||| || |....... 
eveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_PTPN1_pd Subfamily PTPN1 1-166 1.8e-31 103.9 In-house 101-273 (290) alignment 
Range on Protein: 1-166
Range on HMM: 101-273/290.0
MVTNLKEGTKSKCEQYWPNGRA-ESEEFG--PFSVTLVDEQVLPDFVIRSITVMiQDGSNDSHTLTQYHLTSWPDHGVPEYGTPL-MILHR-QSNKSWSP
|. .. |  . || ||||.|   .. ..    ..|.|. |..   ...| . .  .  ..........| |.||| ||||  . .   |.. ..  | |.
mlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllele.nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslss

SKGPILVHCSAGVGRTGTFIAIDIAL---EQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIIC
 .|| ..|||||.||.|||. .|  |   |. .    |||   .  ||..|. ..|| ||  | . ..|| . .
dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-185 3e-31 103.2 In-house 118-257 (392) alignment 
Range on Protein: 1-185
Range on HMM: 118-257/392.0
MVTNLKEGTkskceqywpngraeseefgpfsvtlvdeqvlpdfvirsitvmiqdGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|||.||||                                                .| .| .|.|.| |||..||.. . |. . .. .  .     |.
mvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpl

LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEIPTENYMSTVQKLKE
..||||||||||  |.||  . .||. |.||.  .|  .|..|  |||| .|| |.. .||| ..  .| ||   .   .|.|. 
iihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst
subfamily_PTPN6_pd Subfamily PTPN6 246-401 4.6e-31 102.9 In-house 138-300 (306) alignment 
Range on Protein: 246-401
Range on HMM: 138-300/306.0
ESCYQYWSKT-DSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDT
| |..|| .. .. ..|.. |...| .. . |. |....   |..... .|.|.. ..||. || ..| .||. ..|| ..|...     ||.|||||. 
ekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaG

VSRSGVYCSVSIGLEQCK---AECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
. | | .  . | |.. .    .. .|. .. | ||. . | | | .||  .| .| .|.. .
iGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
0049260 (Phosphotyrosine protein) phosphatases II 1-158 3.4e-30 100.1 In-house 39-144 (152) alignment 
Range on Protein: 1-158
Range on HMM: 39-144/152.0
MVTNLKEGTKSKCEQYWpngraeseefgpfsvtlvdeqvlpdfvirsitvmiqdgsndshtltQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
|.|.| | .| |||||.                                              ||. . |||||||.    |..|..  .| .  ..||.
mltellelgklkceqyi..............................................qylhlpwpDhgvpdlsqlllflllfieklaldkggpv

LVHCSAGVGRTGTFIAIDIALeqakreRVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
|||||||||||||..|... |      . |..  .|...|..|...|.. .|. ||..
lVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1-162 3.5e-30 99.7 In-house 124-281 (290) alignment 
Range on Protein: 1-162
Range on HMM: 124-281/290.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVI-RSITVMiQDGSNDSHTLTQYHLTSWPDHGVPEYGtpLMILhRQsNKSWSPSKGP
|. .| |  |.|||||.|.   |   || ..|.   |.   . .| . ..|. .  |  .| |  ... ||||. |.     | .| |   ..     ||
mlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvr.dkdsGkehklkhlkikswpdksvalst..lall.rt.lrilrkasGp

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
. ||||||.||||||.||...|.     . .|....|  ||. |.. ||   ||. | . .|.
vvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 247-399 5.1e-30 99.0 In-house 127-277 (515) alignment 
Range on Protein: 247-399
Range on HMM: 127-277/515.0
SCYQYWSK--TDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDdssSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSR
 | .|| .  .||.|||.. ||  | .   | . ||...  ..|   |  | | . |.||. || .. ...|..| .|   ....   |...|||  | |
kcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGr

SGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
 ||..|.   . . |   .||||.. . .|. .|  | | |||. ||...  .| 
tGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
0041856 (Phosphotyrosine protein) phosphatases II 6-171 6e-30 99.6 In-house 66-178 (182) alignment 
Range on Protein: 6-171
Range on HMM: 66-178/182.0
KegtkskCEQYWPngraeseefgpfsvtlvdeqvlpdfvirsitvmiqdgSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNkswspSKGPILVHCS
       .|.|||                                     ..  .. .||. ..|||||||.  . | ....  .     ..||.|||||
t......eelywp.....................................ellerlgiqylylpwpDhgvpdldelldfieevle.....eggpvlVHCs

AGVGRTGTFIAIDIALEQakreRvVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICGETEI
||||||||..|... ...    . |..  .|. .|..|..||.|..||.||.. .|| . ...|..
aGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 245-401 6e-30 99.4 In-house 130-287 (297) alignment 
Range on Protein: 245-401
Range on HMM: 130-287/297.0
NESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSsWDVIQLQVTDWPQDGVVR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTV
...| .|||.. . .||.  |. .| .. .|. .|..... .|  .    | | | ..||.. | |  . ...|..|..| .  ..   ||..|||.  |
dkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakar.rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGv

SRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
 | ||....   . . | |  ||.|.. | .|...|  | | |||. .| ..  .|  .
Grtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 247-399 6.4e-30 99.1 In-house 128-278 (315) alignment 
Range on Protein: 247-399
Range on HMM: 128-278/315.0
SCYQYWSK--TDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDdssSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSR
.| ||| .  .||..||.. ||  | .   . . ||. .|  ..   |  | | | |.||. || ..  ..|..| .|    ..    ...||||  | |
kcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee...srtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGr

SGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.|| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||..  .|.
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Ptp69D_pd Subfamily Ptp69D 246-396 2.1e-29 97.6 In-house 131-284 (307) alignment 
Range on Protein: 246-396
Range on HMM: 131-284/307.0
ESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDS----SSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDT
. | .||.. | ...|.  |.  |..  . |..|....   |..|     |  |.| . | |.   | . .|..|..|. | . ...   .|.|||||  
kkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaG

VSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
|.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  .  
vgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralld
subfamily_PTPRK_pd Subfamily PTPRK 247-394 5.9e-29 95.9 In-house 127-273 (314) alignment 
Range on Protein: 247-394
Range on HMM: 127-273/314.0
SCYQYWSKTDSIkFGEYFVESTSHHDFNGYTERKFHIRS-DKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRS
 |..|| .  .. .|.  ||  . .  . .  | | ..   .  .    | |.| . ||. .|  . ...|...  | . |.. . |..|||||    |.
kClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrt

GVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|... ..| |.  . | |||||.. |..| .|.  | | |||. |||||
Gtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
0046846 (Phosphotyrosine protein) phosphatases II 1-161 6e-29 96.4 In-house 53-170 (176) alignment 
Range on Protein: 1-161
Range on HMM: 53-170/176.0
MVTNLKEGTKSKCEQYWPNgraeS----EefgpfsvtlvdeqvlpdfvirsitvmiqdgsndshtltQYHLTSWPDHGVPEYgTPLMILHRQSNKsWSPS
..|...|  . || .|||                                                 ||. . |||||||.. . |. | .. .. .  .
nlteevelgrlkcpnywpe....leklgi......................................qylhlpwpDhgvpdl.elllellefire.alke

KGPILVHCSAGVGRTGTFIAIDialeQAKRERVVDIAGIVNRLRQQRM-KMVQTLDQYVFLHDTVL
.||.|||||||.|||||..|..      ..|. ...  .. ..|.||. ..||| .|| ||.. .|
ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefel
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 245-394 2.4e-28 93.8 In-house 114-262 (283) alignment 
Range on Protein: 245-394
Range on HMM: 114-262/283.0
NESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWpqdgVVREPRTVLQV---IDDVIHRQQKIGGGPVVVHCSDT
.. | ||| |  |...||. |        | .. ... .| .    |.  .   || ||    .  .. ...     .. ||  |..   ||.||||| .
rikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstg

VSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. |..|....|  ... ..| |||||.| | .|  ...|| ||.||  .....
iGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0048076 (Phosphotyrosine protein) phosphatases II 15-160 4.1e-28 93.3 In-house 1-139 (145) alignment 
Range on Protein: 15-160
Range on HMM: 1-139/145.0
QYWPNGRAESEEFGPFSvTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSkGPILVHCSAGVGRTGTF
.|||.   ..  .|..  | .| . | |. |. .  .  . .. ... .||. ..|||||||.    |. . .. ..  .   ||.|||||||||||||.
pywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtl

IAIDIALEqakrERvVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTV
.|... |.    .. |..  .....|.||...|.. .|. ||.. .
vaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefe
subfamily_PTPRG_pd Subfamily PTPRG 246-395 4.8e-28 92.7 In-house 131-284 (563) alignment 
Range on Protein: 246-395
Range on HMM: 131-284/563.0
ESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRS----DKDD-SSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSD
. | .|| | .|...|.  |  .... .  ||.|.. |.     .|..  .   |.| . |.||. ||   .  ||. .     . .|   ||.||||| 
rkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsa

TVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
 |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |||. ..|.. 
GvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall
subfamily_CG7180_pd Subfamily CG7180 247-398 7.2e-28 92.1 In-house 125-290 (296) alignment 
Range on Protein: 247-398
Range on HMM: 125-290/296.0
SCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSD---------KDDSSSWDVIQLQVTDWPQ-DGVVREPRTVLQVIDDVIHRQQKI----GGG
 . .|| ..   ..|| ||| .... .   . |.|..            . .     | ..|.| |.  | |     ......  |   ..|.      |
mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg

PVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
||||..|| .||||||... . ||. . |  ||||.  | .|||.|. | . |.|  ||||.  ..
PvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0043147 (Phosphotyrosine protein) phosphatases II 54-157 3e-27 90.8 In-house 57-154 (172) alignment 
Range on Protein: 54-157
Range on HMM: 57-154/172.0
DGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPILVHCSAGVGRTGTFIAIDIALeqakreRVVDIAGIVNRLRQQRMKMVQTLDQY
|... ...  ||. ..|||||||     | .|.   ..    ..||.|||||||||||||..|... |      . ...  .|. .|..|...||. .||
dpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

VFLH
 ||.
rfly
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 3-160 2e-26 87.4 In-house 112-273 (287) alignment 
Range on Protein: 3-160
Range on HMM: 112-273/287.0
TNLKEGTKSKCEQYWPNGrAESEEFGPFSVTLVDEQVL-PDFVIRSITVMIQDGsNDSHTLTQYHLTSWPDHGVPEY--GTPLMILHR----QSNKSwSP
|   | .. || .|||.        | .||.|.| ... |.. .|.. ..  .. .... . |..| ||||....    |   ..|      . ... . 
treveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielard.as

SKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTV
  ||..||...|.||.|...|. . ... .    ||.| .| |||..|  .||.  |. .| ...
evGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 245-396 2.7e-26 87.5 In-house 129-286 (325) alignment 
Range on Protein: 245-396
Range on HMM: 129-286/325.0
NESCYQYWSKT--DSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDsSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-----GGGPVVVH
...| .|| |   .| .||   |.  .  ..  |  |.....  |.   .  | |.|.  |.. || . | |.. ... | . ....     . .|..||
kdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvh

CSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDM
||. | |.||. |.   |..   |  ||.|.. | .|. .|  | | .||. ||. .  
csaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 247-394 5.3e-26 86.3 In-house 133-275 (315) alignment 
Range on Protein: 247-394
Range on HMM: 133-275/315.0
SCYQYWSKTdSIKFGEYFVESTSHHDFNGYTERKFhirSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSG
 . .||     . .|.. |   |   .. || | .   |   ..   .|.||..| ||. || .   .....|  |   ...   |..|||||. | |.|
kaekywpdk.kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtG

VYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 .....  |.| .|| ..||... . ||. . ..| ..|||  |||..
tfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1-166 7.1e-26 85.9 In-house 112-273 (288) alignment 
Range on Protein: 1-166
Range on HMM: 112-273/288.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPE-YGTPLMILHRQsnkswSPSKGP
|...| |  | | ..|.|    |.  .| .     ....  | ...  .. |.   ...  . . ||  |.|.|||| | .|| .|..         . |
mlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkP

ILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIIC
|.||.|||||||||.| | ||||... .  . |  ....||..|.| .||  ||...|  ||| .. 
ivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1-164 2.2e-25 84.3 In-house 112-277 (307) alignment 
Range on Protein: 1-164
Range on HMM: 112-277/307.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVT-----LVDEQVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKswsp
|. .. | .| |||||||  . .   ||  . |     |  ... ||  .  .| .  | ...| |....  . |||.|||.     . |    .     
mlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....

SKGPILVHCSAGVGRTGTFIAIDIALEQA-KRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAI
 . |..|||||||||.|| .|| .  ..  . .   |.  .|. ||.||   .||  ||..||  .||  
dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0048179 (Phosphotyrosine protein) phosphatases II 33-158 2.3e-25 84.4 In-house 18-139 (144) alignment 
Range on Protein: 33-158
Range on HMM: 18-139/144.0
TLVDEQVLPDFVIRSITVMIQDGSNDSHTLT--QYHLTSWPDHGVPEYGTPLMILHRQSNKSWSpSKGPILVHCSAGVGRTGTFIAIDIALeqakRERvV
|..| . | .. |. .  .. .  ... . .  ||. ..|||||||.. . |  . .  ..  . ..||.|||||||||||||..|... .    ... .
taldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.l

DIAGIVNRLRQQRMKMVQTLDQYVFLHD
..  .....|..|. .|.. .|. ||..
sleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 247-400 2.8e-25 84.0 In-house 114-270 (274) alignment 
Range on Protein: 247-400
Range on HMM: 114-270/274.0
SCYQYWSKTDSI----KFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSswdVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSD
 | .|. .. ..    ..|.  .. ..  . |.|. ||. ... ..  |   |.    ||||   . ....|.|.....| . ...     .||||||| 
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsa

TVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQM
 . | |.. ..||.. | ..| ||||....  .|  . | | | |||  |. .. .||. 
GiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 247-399 5.8e-25 83.0 In-house 125-277 (281) alignment 
Range on Protein: 247-399
Range on HMM: 125-277/281.0
SCYQYWSKTD-SIKFGEYFVESTSHHDFNGYTERKFHIrsDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRS
 |..||   . ..|.|.. |.||.... . | ||||..  ..... . .| ||. | ||. ||  ... .|.  ..| . ..|    |.|.|||  | |.
kChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrt

GVYCSVSIGLEQCKAE-CVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
|.| ..   .....||   .|| .| . .|...   | |. ||. .| ..  .|.
GtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 246-395 6.9e-25 82.7 In-house 130-276 (288) alignment 
Range on Protein: 246-395
Range on HMM: 130-276/288.0
ESCYQYWSKTDS-IKFGEYFVESTSHHDFNGYTERKFHIRsdkDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSR
. | .|| ..|   ..|.  |. ..... . ...||. .     . .  .. |.| . ||..|| .  . .|.... |   .|.   ||..||||. | |
tkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGr

SGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
.|.. ..   ... ..| ..||. . . .|....  | ||.||  ||.|. 
tgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1-166 8.9e-25 82.2 In-house 105-272 (285) alignment 
Range on Protein: 1-166
Range on HMM: 105-272/285.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLV--DEQVLPDFVIRSITVM-IQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKsWSPSK
|.  | ||   ||  |.|.   |  .|| . .||    |. .   .. ..||.  .| |..   . . ..  |||.  ||   |.. |..  .|   | .
mlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpke

GPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIIC
 || |||||||||| ||. || |  .   .  ...  ||  .|  |.. ||.  |..||.  ..| .| 
kpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig
0051082 (Phosphotyrosine protein) phosphatases II 2-160 1.1e-24 82.1 In-house 40-149 (151) alignment 
Range on Protein: 2-160
Range on HMM: 40-149/151.0
VTNLKEGTksKCEQYWPN-GraeseefgpfsvtlvdeqvlpdfvirsitvmiqdgsndsHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKswsPSKGPI
.....|    .| .|.|. |                                       ..........|||.|.|..   .. .... ..   ...||.
lrseeerg..ycpeylpelg.......................................ievlhipildwpdpglplsfdavleflellld...kkngpv

LVHCSAGVGRTGTFIAIDIALEQakrervVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTV
|||||||.|||||..|... |..      |... ... .|..|. .||. .|..|..  .
lvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
PTPc_DSPc_SM00012 295-394 3.1e-24 80.5 In-house 2-103 (105) alignment 
Range on Protein: 295-394
Range on HMM: 2-103/105.0
VIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-CVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
| ....|.||. || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...|   ||.||. |..|...||.|.|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 43-162 3.2e-24 80.2 In-house 169-285 (305) alignment 
Range on Protein: 43-162
Range on HMM: 169-285/305.0
FVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSnkswSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVV-DIAGIVNRLRQ
 ...   ..|.   ....  |.||   ||| |||   . .. |  ..     |||||| ||||||.||||. . ..  |.|    ... |   |....|.
akvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkire

QRMKMVQTLDQYVFLHDTVLE
|| . .|| .||.|.|. .|.
qrnnsiqtdaqylfvhqviln
0044763 (Phosphotyrosine protein) phosphatases II 1-159 5.6e-24 80.2 In-house 54-166 (178) alignment 
Range on Protein: 1-159
Range on HMM: 54-166/178.0
MVTNLKEGTKSKCEQYWPNGRAeseefgpfsvtlvdeqvlpdfvirsitvmiqdgsndshtlTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPI
..|. .|. . || .||| .                                           ||. . .||||||.    .. ...  ..  ....||.
nlteelelgflkcdpywpeeag........................................iqylhipipDhgvpdllehflefvefieealdekggpv

LVHCSAGVGRTGTFIAIDIALEQakreRVvDIAGIVNRLRQQRMkMVQTLDQYVFLHDT
||||||||||.||..|... ...    .. ..  .....|..|. .|.. .|. .|.. 
lVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyef
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 245-393 8.8e-24 79.4 In-house 137-286 (319) alignment 
Range on Protein: 245-393
Range on HMM: 137-286/319.0
NESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVS
.. | ||| .   || ... |. .| .. . |. |....  |       .. |     ||. ||   |  ...... | | ..|  .  ..|||||  | 
kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvG

RSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
|.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
rtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_PTPRB_pd Subfamily PTPRB 247-399 9.1e-24 79.0 In-house 135-286 (293) alignment 
Range on Protein: 247-399
Range on HMM: 135-286/293.0
SCYQYWSKT-DSIKFGEYFVESTSHHDFNGYTERKFHIRSdkdDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSR
 | .|| .. ... .|.  |. ..... . .. |...|.    .... .| |.. | ||. ||  ...|.|. .  | ... ..   .|.|||||  | |
kCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGR

SGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.|.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .|.
tGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 246-393 1.2e-23 79.0 In-house 102-250 (284) alignment 
Range on Protein: 246-393
Range on HMM: 102-250/284.0
ESCYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSR
. | ||| .   || ... |. .| .. . |. |....  |       .. |     ||. ||   |  ...... | | ..|  .  ..|||||  | |
dkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

SGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_PTPN12_pd Subfamily PTPN12 247-399 1.5e-23 78.2 In-house 124-278 (290) alignment 
Range on Protein: 247-399
Range on HMM: 124-278/290.0
SCYQYWSKT--DSIKFGEYFVESTSHHDFN-GYTERKFHIRSDkddSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVS
 | .||...  ....|||. |. .... .. ... | .... .   . |  | |.. |.||  || . . ..|..|..| ..|.     |.|||||  | 
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvG

RSGVYCSVSIGLEQCKAECV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
| |. ... .  |. ||| .   .|||..   .|. .. .| | |||. .|  .  ..|
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
0051429 (Phosphotyrosine protein) phosphatases II 236-398 2.3e-23 78.7 In-house 4-225 (272) alignment 
Range on Protein: 236-398
Range on HMM: 4-225/272.0
NGYINASYLN-----------------------------------------------ESCYQYWS------------KTDSIKFGEYFVESTSHHDFNGY
.|||||....                                               . |..||              . .| .| ..|  .| . .. |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

TERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPrtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVD--------VFQ
. |.. ..   . . .  | .|. |||| .|| .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .|..||        ...
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

VTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
. . .|.  |||| | |||  .|...  .|
aveelraqrpgavqteeqylflyeallell
subfamily_PTPN3_pd Subfamily PTPN3 247-394 3.6e-23 76.9 In-house 125-271 (280) alignment 
Range on Protein: 247-394
Range on HMM: 125-271/280.0
SCYQYWSK-TDSIKFGEYFVESTSHHDFNGYTERKFHIRsDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRS
 |.||| . .|....||. |. ....  . |  |.. .. ||. . .  ..||| ..||. ||  ..  .|.... | .....    |||||||  . |.
kChqyWPetedeleygefsvkcekedetksyvlrelvlk.dketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrt

GVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
||.  . . |    |.  | . .. . .|  .   | | .||. . . |
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 12-162 7.8e-23 75.8 In-house 110-257 (267) alignment 
Range on Protein: 12-162
Range on HMM: 110-257/267.0
KCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDgsNDSHTLTQYHLTSWPDH-GVPEYGTPLMILHRQsnKSWSPSKGPILVHCSAGVGR
.  ..||   ......  ..|    |.   |. | .. . ...  . .| .| |.   |        |  ||. .  .  .       |..|.||.||||
nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn..esahnvtlyyykkwnintnnkpylkplfgilak..nqlengnrPlvvacsdGvGr

TGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
.|||. ||  ||.||.| |.||   . ..|.||. .|.|...|...|... |
sGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 245-394 1.1e-22 75.4 In-house 84-235 (237) alignment 
Range on Protein: 245-394
Range on HMM: 84-235/237.0
NESCYQYWSKTDSI-KFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTV
.. |..|| .||    .| . |  . . .|  || | . .           . | | | ||. || ..  ..|.   ..|.| ...   || ..|||  |
elkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagv

SRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 |.|..  .   | |.| . |||...  ...   .|  . | .||  |...|
grtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1-156 1.5e-21 71.5 In-house 120-273 (301) alignment 
Range on Protein: 1-156
Range on HMM: 120-273/301.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQ-VLPDFVI-RSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKswspSKG
|...  | ...|||.| |   .|. . | |........ .| . .. |.. |    |  ...|.| |  ..|.|.|||.  . |. |     |    |. 
mlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sek

PILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFL
||.||||||.||. .||. ..   . . .. ....  ...||..| . |||  |  ..
PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 6-163 1.8e-21 71.1 In-house 131-288 (305) alignment 
Range on Protein: 6-163
Range on HMM: 131-288/305.0
KEGTKSKCEQYWPNGRAESEEFGPF-SVTLVDE--QVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGtpLMILHRQSnkSWSPSKGPILV
 |  | || ||||  . |  |.     |  |     .  |  |.  .. .    ... .. . . | ||| |||     |  |   |  .   || ||.|
velgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppck..ltslells..airgskvpivv

HCSAGVGRTGTFIAIDIALEQ-AKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEA
|||||.||||| .||.  ||. |.  ..  .  .|. ||.||   .|.  ||.|.|  .|. 
hcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 246-401 2.2e-21 71.0 In-house 104-267 (270) alignment 
Range on Protein: 246-401
Range on HMM: 104-267/270.0
ESCYQYWSKTD----SIKFGEYFVESTSHHDFNGYTERKFHIRsdkDDSSSWDVIQLQVTDWPQDGVVREPR------TVLQVIDDV-IHRQQKIGGGPV
. | .||..      ....|.  | ..|..  .||  .. ...   .....  ..  . ..||..||.||.        .|... .|  .....  ..|.
kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePl

VVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
.||||. | |.|.   . |...  . .  ||| .. ...|. ..  | . |||. .| .. .| .. 
lvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN13_pd Subfamily PTPN13 248-399 2.1e-20 68.1 In-house 119-270 (273) alignment 
Range on Protein: 248-399
Range on HMM: 119-270/273.0
CYQYWSKT--DSIKFGE-YFVESTSHHDFNGYTERKFHIRsDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSR
| .|| ..  ...|  . . ||     . .|.. |..... |.. . | .| .|. ..||  || ...  .||..  | . |.    ||.|||||  . |
chrywPesknkklkvsnrlevellkvqkldgfvvralavk.dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGr

SGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
||.. .. . |.  . .  .|| .. . .|. . | | | .||  .| .|   |.
sGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 3-163 2.3e-20 67.3 In-house 123-287 (302) alignment 
Range on Protein: 3-163
Range on HMM: 123-287/302.0
TNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVD-EQVLPDFVIRSI----TVMIQDG---SNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNkSWs
....|. . || .|. .   .  .|| ..|. |. .. | .|  .      || |..    ..  .|.   . ..||||| |.   . . . .  . |. 
csfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfce.sy.

psKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEA
  |  .|||||||||||||..||   ..  ....| |.. ||  .|| |   ||. .| ..|   |  .
..kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
0049772 (Phosphotyrosine protein) phosphatases II 60-163 4.8e-20 67.9 In-house 178-279 (314) alignment 
Range on Protein: 60-163
Range on HMM: 178-279/314.0
HTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKswsPSKGPILVHCSAGVGRTGTFIAIDIALEQAKrervVDIAGIVNRLRQQRM-----KMVQTLDQYV
..  .|. . .||...|     . .|.   .    . .||.||||.||.||||||..... . . .    |... .....|..|.      ....|.||.
rlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqye

FLHDTVLEA
| .. .||.
filealley
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 82-164 7.4e-20 66.0 In-house 213-295 (297) alignment 
Range on Protein: 82-164
Range on HMM: 213-295/297.0
LMILHRQSNKSWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAI
...|  .| ..  | . ..||||||||||.|  .  |. |.. ...|. |.| |.. ||.|| ..||||.|. .|.| ||. .
mvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_PTPN9_pd Subfamily PTPN9 247-397 7.6e-20 66.1 In-house 126-289 (297) alignment 
Range on Protein: 247-397
Range on HMM: 126-289/297.0
SCYQYWS--KTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSsSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ------------KIGGG
 | |||   . .|..||.. |.. . .  . |..|...|.  |..  |  |.  |.. ||  || ..  ..|.|.. | ..|             .. | 
kcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktee.srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgP

PVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMY
|.|||||  . |.| .... | |.. . . .|||... | .|  .  .. | |||.  |  .  |
PivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 238-394 9.4e-20 65.5 In-house 119-275 (439) alignment 
Range on Protein: 238-394
Range on HMM: 119-275/439.0
YINASYLNEScYQYWSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSS-SWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVV
 .. . | || |.||   . . .|.  |      ..  |. | |..  ..| .     |.|.. . ||.  |  .   ||. .  .   ..|   |||||
ivmltnlves.ykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvv

HCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|||  | |.|   .. | ||| |.|  ||.  . | .|. .   | .| ||  ||. .
hcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_PTPN23_pd Subfamily PTPN23 246-394 1.2e-19 65.3 In-house 123-276 (288) alignment 
Range on Protein: 246-394
Range on HMM: 123-276/288.0
ESCYQYWSK--TDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKdDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIH---RQQKIGGGPVVVHCSD
... .|| .   .. |||.. |   |... . . ||.....  .  .   .|  ||.| ||. ||   | |.||..| | .    .|.    |.||||| 
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld.adavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsa

TVSRSGVYCSVSIGLEQC-KAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 | |.||.. |   ...  | . ..|. || . .|. .   | . ||.   |...
GvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1-162 3.2e-19 63.7 In-house 111-267 (281) alignment 
Range on Protein: 1-162
Range on HMM: 111-267/281.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIqDGsnDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNkswSPSkGPI
|. .. |  . || .|.|       .|  .||.  |  |   .|   . .   .|  ... .|..    |||  |||    .. . |.     . |  | 
mlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy.eg..etrlithwlwkewpdwqvpessevmlkilrkir...ars.tpp

LVHCSAGVGRTGTFIAIDIALEQAKRE-RVVDIAGIVNRLRQ-QRMKMVQTLDQYVFLHDTVLE
..||||||||.||..|..|||.  .    . ||  || .||   |   ||||.||...   .|.
vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0036282 (Phosphotyrosine protein) phosphatases II 243-392 3.7e-19 64.5 In-house 9-164 (174) alignment 
Range on Protein: 243-392
Range on HMM: 9-164/174.0
YLN----------------------------------------ESCYQYWSKtdsikfgeyfvestshhdfngyterkfhirsdKDDSSSWDVIQLQVTD
.|.                                        . |..||.                                 . .. .  .||.. . 
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpe................................lredlerlgiqylylp

WPQDGVVREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|| .||   .  .|.... | . ... .||||.||||  |.|.|. .   . | . . | .||.... ...|. .||.|.| .||  .|.
wpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_CG42327_pd Subfamily CG42327 94-160 8.2e-19 62.4 In-house 244-311 (319) alignment 
Range on Protein: 94-160
Range on HMM: 244-311/319.0
SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRE-RVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTV
  |.||. |||| ||||||. || |||... .   | |||  .|  .|..| . |.| .|| |.. ..
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_PTPN14_pd Subfamily PTPN14 246-399 1.4e-18 62.0 In-house 133-297 (300) alignment 
Range on Protein: 246-399
Range on HMM: 133-297/300.0
ESCYQYWSKT----DSIKFGEYFVESTSHHDFNGYTERKFHIRSDKdDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDV---IH-RQQKI----GGGP
| ...|. |.    ....||.. | .  ..| . .. ......     .   .|. || ||||..|| ..... |. ...|    .  ....       |
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

VVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
|.||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.|.  ||.
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 245-391 1.6e-18 61.8 In-house 90-233 (239) alignment 
Range on Protein: 245-391
Range on HMM: 90-233/239.0
NESCYQYWSKTDSiKFGEYFVESTSHHDFNGYTERKFHIrSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSR
.. |.|||  . | |. .  |       |  |  | | . |.  ..    | | ..| ||. || .   .|| .    | ..   |  | |.|||  | |
kkkchqywpdsts.kycnlrvtlrktevfadyiirtfvm.sqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgr

SGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
tgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 96-161 2.2e-18 61.1 In-house 261-341 (350) alignment 
Range on Protein: 96-161
Range on HMM: 261-341/350.0
SKGPILVHCSAGVGRTGTFIAIDIALE-------QAKRERV-------VD-IAGIVNRLRQQRMKMVQTLDQYVFLHDTVL
   |||||||||||||||....|  |.         |. |         | |  |||.||.||..|||.|||..|.....|
rsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 200-394 2.2e-18 60.8 In-house 30-232 (392) alignment 
Range on Protein: 200-394
Range on HMM: 30-232/392.0
PDPNDVHCNSA--KAHATKNRSNKYLPPDKFIVAL-----KEANGYINASYL----NESCYQYwSKTDSIKFGEYFVESTSHHDFNGYTERKFHIRSDKD
|.|.  . ..|  .    ||| .. || |.  | |        . |.||||.    || .|   |..  .   . | .   ...    .  .     || 
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayia.sqgpnaaslddfwrmvfqenvttiamvtklkegdkg

DSsSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYT
|.    | | ..|.||...| .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | |||.
dd.artvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqya

SIYDVI
 ||  .
fiygav
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 46-170 2.4e-18 60.9 In-house 163-282 (312) alignment 
Range on Protein: 46-170
Range on HMM: 163-282/312.0
RSITVMIQDGSNDShTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKswspSKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMK
| . |...   ..|  | .|  .||||||.|.     . |    .|     | |.. |||||||||||.. |.  .   .  |  ..  .   ||..| .
rvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrar

MVQTLDQYVFLHDTVLEAIICGETE
 |... |||.   .||| . .    
svrvfpqyvyalrcvleflyskgly
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 10-157 2.5e-18 60.9 In-house 44-197 (199) alignment 
Range on Protein: 10-157
Range on HMM: 44-197/199.0
KSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSND-SHTLTQYHLTSWPDHGVPEYGT--PLMILHRQSNKSWSPSK-GPILVHCS
..    |||   . . ..| .|||     . ||..| .. .  .  .   .  ...| .||| ..  |.      ...  |.  | .   |  |..||||
eadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcs

AGVGRTGTFIAIDIALEQA--KRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
 | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
dgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 10-157 2.5e-18 61.0 In-house 43-196 (198) alignment 
Range on Protein: 10-157
Range on HMM: 43-196/198.0
KSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGSND-SHTLTQYHLTSWPDHGVPEYGT--PLMILHRQSNKSWSPSK-GPILVHCS
..    |||   . . ..| .|||     . ||..| .. .  .  .   .  ...| .||| ..  |.      ...  |.  | .   |  |..||||
eadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcs

AGVGRTGTFIAIDIALEQA--KRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
 | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
dgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 245-391 2.6e-18 61.0 In-house 91-234 (239) alignment 
Range on Protein: 245-391
Range on HMM: 91-234/239.0
NESCYQYWSKTDSiKFGEYFVESTSHHDFNGYTERKFHIrSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSR
.. |.|||  . | |. .  |       |  |  | | . |.  ..    | | ..| ||. || .   .|| .    | ..   |  | |.|||  | |
kkkchqywpdsts.kycnlrvtlrktevfadyiirtfvm.sqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgr

SGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |.
tgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
0041856 (Phosphotyrosine protein) phosphatases II 215-399 4.7e-18 60.9 In-house 3-172 (182) alignment 
Range on Protein: 215-399
Range on HMM: 3-172/182.0
TKNRSNKYLPPDKFIvalkeANGYINASYLNESCY------------------------------------QYWSktdsikfgeyfvestshhdfngyte
.|||  ..||.|  .      . ||||...  |..                                    .||                          
dknrysdilpydhsr.....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywp.........................

rkfhirsdkdDSSSWDVIQLQVTDWPQDGVVRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeCvVDVFQVTKAVRRSKP
          .     .||.. . || .||   ....|. |..|..      ||||.||||  |.|.|...   . ...      |..... | ||. .|
..........ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRp

GAVTTLEQYTSIYDVIDMYLQ
|.|.|..||  ..... ..|.
gmvitpnqyfflqlallelll
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 101-167 9.1e-18 58.4 In-house 2-68 (69) alignment 
Range on Protein: 101-167
Range on HMM: 2-68/69.0
LVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICG
.||||.| ||||||||| . . . | |..|||   |. .|. |  ||    .|.|.||.. ||.  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 102-167 1.4e-17 57.8 In-house 2-67 (69) alignment 
Range on Protein: 102-167
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIICG
||||.| ||||||||| . . . | |..|||   |. .|. |  ||   ..|.|.||.. ||.  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
0043147 (Phosphotyrosine protein) phosphatases II 288-392 5.3e-16 54.3 In-house 58-155 (172) alignment 
Range on Protein: 288-392
Range on HMM: 58-155/172.0
DDSSSWDVIQLQVTDWPQDGVVrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeCVVDVFQVTKAVRRSKPGAVTTLEQY
 .  .  .||.. . ||  ||   .. .|.... . .....  ||||.||||  |.|.|. .   . |      . ...... . ||. .||||.. .||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

TSIYD
  .|.
rflyy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 9-170 1.2e-15 52.4 In-house 108-257 (290) alignment 
Range on Protein: 9-170
Range on HMM: 108-257/290.0
T-KSKCEQYWPNGRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGsnDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKswspSKGPILVHCSAG
| .  |..| |.   |.  |. ..|   .     |. .| ..|  .|.    .|.| . | .| .  |.|    |. | .. ..    || |..|||  |
tslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdG

VGRTGTFIAIDIALEQAK-RERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLeaiicgetE
. |  .. ||...       .  | .. ... ||.|| .....  .. |    ..         
iSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv........l
subfamily_ptpA1_pd Subfamily ptpA1 6-121 1.5e-15 51.9 In-house 124-253 (418) alignment 
Range on Protein: 6-121
Range on HMM: 124-253/418.0
KEGTKSKCEQYWPNGR---------AESEEFGPFSVTLVDEQVLPDF--VIRSITVMIQdgsNDSHTLTQYHLTSWPDHGVPEYGTPLM-ILHRQSNKS-
 |  . ||..|||.              | || .|| ||.    |.   . | | . ..    ... .|||.   |||| .|..  |.  .||  .|.  
sencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe...getrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

----WSPSKGPILVHCSAGVGRTGTFIAIDIAL
     |  . ||.||||||||||||| .  | .
qiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1-185 3.5e-15 50.8 In-house 58-236 (255) alignment 
Range on Protein: 1-185
Range on HMM: 58-236/255.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDeqVLPDFVIRSITVMIQDG-SNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSwspsKgP
|.....| .. ||..|.|  . |   .   .||  .     | |.| .... . |     ||.. |. . |...  ||    .. . .   .|    | .
mlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvvrds....k.s

ILVHCSAGVGRTGTFIAIDIALE----Q--AKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAIicgeteIPTENYMSTVQKLKE
..||||.|.||. .|. ....      .        .|   ... ||..| . ..|  |  |   .||. .       | ...    |....
vvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv......fpkgeleakyqeirk
0046846 (Phosphotyrosine protein) phosphatases II 247-398 4.4e-15 51.4 In-house 64-173 (176) alignment 
Range on Protein: 247-398
Range on HMM: 64-173/176.0
SCYQYWSKTDSIKFgeyfvestshhdfngyterkfhirsdkddssswdviQLQVTDWPQDGVVREpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSG
.|..||.   . ..                                    | ....||  ||    . .|.... .  ....  ||||.||||  ..|.|
kcpnywpeleklgi....................................qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtg

VYCSVSigleQCKAECVVDVFQVTKAVRRSKP-GAVTTLEQYTSIYDVIDMYL
...        .. |. ..|... . ||. .| |||.| |||  .|... ..|
tlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_PTPN1_pd Subfamily PTPN1 247-391 4.7e-15 50.1 In-house 112-264 (290) alignment 
Range on Protein: 247-391
Range on HMM: 112-264/290.0
SCYQYWSKTDS---IKFG--EYFVESTSHHDFNGYTERKFHIRsDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSD
 |.||| . ..   ...   .. |.  |... . || |....  ..    . ....   | ||  || . | . |. . .| .    .   ||.|.||| 
kcaqywPqgeeekellledtklkvkliseerksyytvrllele.nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

TVSRSGVYCSVS---IGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
 . ||| .| |    . .|. .    ||. .|  ..|. . | . | .|    |
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 6-172 8e-15 49.2 In-house 129-297 (310) alignment 
Range on Protein: 6-172
Range on HMM: 129-297/310.0
KEGTKSKCEQYWPNGrAESEEFGPFSVTLVDEQVlPDFVIR---------SITVMIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPlMILHRQSNKSwspS
 |  . ||  |||     .| .|   || . |    .| |           . |  |    .   ..  .   ||| |||.      .  |   .     
geegrpkcvgywpsl.gvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch.tvpqrllaqv...r

KGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLeAIICGETEIP
.|| .||||||..|... .|.........|   ||.  ..  |...|.. .||  ||....   . ..  ||||. 
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargeteva
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 54-160 9.5e-15 48.8 In-house 175-281 (302) alignment 
Range on Protein: 54-160
Range on HMM: 175-281/302.0
DGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQY
.|  .|   . |.|| |... ||.  . |.    .  .. .... ....    |.|| |.|..  .|.|. ...  . |. ||. .|.|| ..|..|.||
egcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQy

VFLHDTV
|.|. ..
vslyial
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 243-399 9.5e-15 49.5 In-house 109-260 (290) alignment 
Range on Protein: 243-399
Range on HMM: 109-260/290.0
YLnESCYQYWSKT--DSIKFGEYFVESTSHHDFNGYTERKFHIRSDkdDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqkiggGPVVVHCSD
 | ..| .|  ..  ...||.   |. .|    ..  .|.  .. |  |   . |   .. .| .  | ....|.|..|. |  ..      ||.||| |
sl.faCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd..deeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvd

TVSRSGVYCSVSIGLEQCK-AECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
 .||| .  .. .|       .  | . .| ||.|. .  |.|. .... .  .| ....
GiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllai
0051082 (Phosphotyrosine protein) phosphatases II 240-393 1.7e-14 49.1 In-house 7-148 (151) alignment 
Range on Protein: 240-393
Range on HMM: 7-148/151.0
NASYLNE----------------------------------SCYQYWSKTDsikfgeyfvestshhdfngyterkfhirsdkddsssWDVIQLQVTDWPQ
|.||. .                                   |..|. ...                                     .|......||| 
nfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg....................................ievlhipildwpd

DGVVREPRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaecvVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 |.   . .||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
pglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 322-395 1.8e-14 48.4 In-house 183-256 (267) alignment 
Range on Protein: 322-395
Range on HMM: 183-256/267.0
VIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
. . | . |. |.||.||| | ||| .  .   ||. | | |.|.|.  . .|  ..| | |.|.|  |.... 
laknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 247-394 2.5e-14 47.6 In-house 135-279 (290) alignment 
Range on Protein: 247-394
Range on HMM: 135-279/290.0
SCYQYWSKT--DSIKFGEYFVESTSHHDFNGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSR
 | ||. ..  . . |||. |  . ..| .  . .|     |||.  .  .  |..  ||.  |     ..|...  .  |.     ||||||||  . |
kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGr

SGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.| . .. .||.       .|. .. .|.|.|. ..|    ||  . ...
tGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil
0049260 (Phosphotyrosine protein) phosphatases II 247-392 3.8e-14 48.1 In-house 50-144 (152) alignment 
Range on Protein: 247-392
Range on HMM: 50-144/152.0
SCYQYWsktdsikfgeyfvestshhdfngyterkfhirsdkddssswdviQLQVTDWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSG
 |.||.                                            | . . || .||   .  .|.... . .. ..  ||||.||||  |.|.|
kceqyi............................................qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtg

VYCSVSIGLeqckaeCVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
...   . |      . |..... . ||. .||||.. .|.  .|.
tlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPRN_pd Subfamily PTPRN 247-392 4.2e-14 46.9 In-house 141-286 (297) alignment 
Range on Protein: 247-392
Range on HMM: 141-286/297.0
SCYQYWSKTDSIKFGEYFVESTSHHDF-NGYTERKFHIRSDKdDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRS
 |..|| .. |  .. | |.  | | . . |  | |...  .  | .  | |.    ||. ||  .....|.    |  .  .    |.|||||| . |.
qckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrt

GVYCSVSIGLEQC-KAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
|||. . . |..  |    .|.    . .|  .|| | | .|.  .. 
GvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_egg_pd Subfamily egg 6-165 1e-13 45.7 In-house 118-274 (307) alignment 
Range on Protein: 6-165
Range on HMM: 118-274/307.0
KEGtkSKCEQYWPNGRAESEEF--GPFSVTLVDEQVLPDF--VIRSITVmiqDGSNDSHTLTQYHLTSWPDhgVPEYGTPLMILHRQSNKSwspskGPIL
||    .|| |||.  ..|  .  | . .. .. .  .|    .  . .    |..|     ..    .    . .  .|| .| .  | |      |..
kes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl...vGgddeerflehwqgdvnn..ssdvysplrvlrklrnls.....kpvv

VHCSAGVGRTGTFIAIDIALEQAKRERVV--DIAGIVNRLRQQRMKMVQTLDQYVFLHDTVL---EAII
|..  || ...|..||.||| .  |  ..   .   |  ||..|   |..  .|.|..  ||     .|
vqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi
0048076 (Phosphotyrosine protein) phosphatases II 291-397 1.6e-13 46.0 In-house 43-142 (145) alignment 
Range on Protein: 291-397
Range on HMM: 43-142/145.0
SSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSIGLEqckaECvVDVFQVTKAVRRSKPGAVTTLEQYTSI
 .  .||.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.|...   . |.    .  |..... . ||.  ||||.. .|.  .
lerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrfl

YDVIDMY
|... ..
yefelel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 97-162 2.3e-13 44.2 In-house 265-342 (349) alignment 
Range on Protein: 97-162
Range on HMM: 265-342/349.0
KGPILVHCSAGVGRTGTFIAIDIALE--QAKRER---------VV-DIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLE
  ..||||||| ||||... .|. |.  .  ..              |  ||| ||.||. ||| | |........|.
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
0049772 (Phosphotyrosine protein) phosphatases II 213-400 2.4e-13 46.0 In-house 46-282 (314) alignment 
Range on Protein: 213-400
Range on HMM: 46-282/314.0
HATKNRSNKYLPPDkFIVALK----EANGYINASYLNEScYQY------------------------WSKT-----------------------------
. .|||. . || |   | |.    .  .||||||..    ..                        |. .                             
nrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAl

---DSIKFGEYFvestSHHDFNGYTERKfHIRSDKdDSSSWDVIQLQVTDWPQdGVVREPRTVLQVIdDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVS
     ... ...    .. ..  . . |  .  |. .  .  .|..  ...|  | .  .. ..... ..|..     ||||.|||.. ..|.|... . 
gKtpllildgng....neptaadlellk.eelydp.elferlgikylripvpD.gsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaa

IGLEQCKaecvVDVFQVTKAVRRSKP-----GAVTTLEQYTSIYDVIDMYLQM
. . ...    |.. .. . ||.  |     |.. .||||  |.... .||..
ylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 248-390 5.1e-13 43.1 In-house 133-280 (302) alignment 
Range on Protein: 248-390
Range on HMM: 133-280/302.0
CYQYWSK--TDSIKFGEYFVESTS-HHDFNGYTERKF------HIRSD-KDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigggpVVVH
| .|.|.   . .|||.| |.. | ..|.. .|..|        |. . | .     |  |. . ||. |  .|. | |...      ...     |.||
caeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn.....vlvh

CSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSI
||  | |.|   ..  |.. |. . | |. .. . ||. . ||| . .| . .
csaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_CG42327_pd Subfamily CG42327 330-398 9.1e-13 42.5 In-house 246-315 (319) alignment 
Range on Protein: 330-398
Range on HMM: 246-315/319.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-CVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYL
  ||.|||||| | |.|.  .  | ... .     ||. |.   ||| .  || | |||  || |. .| 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
0048179 (Phosphotyrosine protein) phosphatases II 280-392 1.2e-12 43.3 In-house 48-139 (144) alignment 
Range on Protein: 280-392
Range on HMM: 48-139/144.0
KfhirsdkddssswdVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIGLeqckAECvVDVFQVTKAVRRSKPG
               .||.. ..||  ||   .  .|.... . . ..   ||||.||||  |.|.|...   . .     .  ...... . ||.  ||
e..............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpg

AVTTLEQYTSIYD
||.. .|.  ...
avpnpgqlrfLle
0044763 (Phosphotyrosine protein) phosphatases II 246-401 3.7e-12 41.7 In-house 64-174 (178) alignment 
Range on Protein: 246-401
Range on HMM: 64-174/178.0
ESCYQYWSKTDSikfgeyfvestshhdfngyterkfhirsdkddssswdvIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRS
..|..|| .  .                                      || . . .| .||   .. .|... . |.. ..  ||||.||||  |.||
lkcdpywpeeag......................................iqylhipipDhgvpdllehflefv.efieealdekggpvlVHCsaGvgRs

GVYCSVSIGLEQckaeCVvDVFQVTKAVRRSKPgAVTTLEQYTSIYDVIDMYLQMN
|. .   . ...     . ..... . ||. .| .|.. .|.  .|..  ..|...
gtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrllkes
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 247-401 4.8e-12 40.3 In-house 121-280 (287) alignment 
Range on Protein: 247-401
Range on HMM: 121-280/287.0
SCYQYWSKTD-SIKFGEYFVESTSHHDFN-GYTERKFHIRsDKDDSSSWDVIQLQVTDWPQDGVVRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSD
 ||.|| . .  .. | | |   ..   .  |. | . .  | .   .  | ||.. .||....        | ||.| . .  ...  . ||.|||.. 
kcykywPerevPmrvGGysvvlldydikePeygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv

TVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQMN
 . |||.. .. . ... .    ||| .|   .|  . . | .  |.  .|. .  | . |
GiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_hpo-7_pd Subfamily hpo-7 1-165 7.8e-12 39.6 In-house 64-228 (263) alignment 
Range on Protein: 1-165
Range on HMM: 64-228/263.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEQVlpDFVIRSITVMIQDG-SNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSwspsKgP
|... .|  . ||..|.|  . |   .   .|.  . |   | ..... .. . |     ||...|  . |...  ||     . . .   .|    | .
mLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvarns....k.s

ILVHCSAGVGRTGTFIAIDIALE----QAK--RERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAII
. ||||.|.||.  |  ....      . .      .|   ... ||..| . ..|  |  |   .||. ..
lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 182-245 2.9e-11 37.9 In-house 16-80 (287) alignment 
Range on Protein: 182-245
Range on HMM: 16-80/287.0
KLKETGIKAQFGLLHQVTPDPNDVHCNSAKAHATKNRSNKYLPPDKFIVALKE-ANGYINASYLN
.  ..| | || .|.||| ....|  | |.    |||... |.||.. | ||.  . ||||....
akgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfid
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 321-393 3.1e-11 37.8 In-house 124-198 (198) alignment 
Range on Protein: 321-393
Range on HMM: 124-198/198.0
DVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
.| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
evskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 321-393 3.2e-11 37.8 In-house 125-199 (199) alignment 
Range on Protein: 321-393
Range on HMM: 125-199/199.0
DVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
.| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
evskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1-76 3.5e-10 34.2 In-house 106-180 (297) alignment 
Range on Protein: 1-76
Range on HMM: 106-180/297.0
MVTNLKEGTKSKCEQYWPNGRAESEEFGPFSVTLVDEqVLPDFVIRSITVMIQDGSNDSHTLTQYHLTSWPDHGVP
||..|.|. ..||  |||.   |  . | . |  . . .  .|    .| .     ..|  ..     ||||||||
mvaklqedGrdkcapywpsvvqerlkagdvvveflss.tsdefdrviltelqliyrsesrvvrhvqflswpdhGvp
0038934 (Phosphotyrosine protein) phosphatases II 64-117 5.1e-09 31.5 In-house 81-135 (194) alignment 
Range on Protein: 64-117
Range on HMM: 81-135/194.0
QYHLTSWPDHG-VPEYGTPLMILHRQSNKSWSPSKGPILVHCSAGVGRTGTFIAI
.|.   .||.| || . . | .|.    .    ..| ..||| ||.|||||..| 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 293-397 7.9e-09 29.9 In-house 176-276 (307) alignment 
Range on Protein: 293-397
Range on HMM: 176-276/307.0
WDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIGLEQC-KAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
  . .|| ..||. || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  ..
rtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylh

DVIDMY
 |.  |
rvlley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 185-245 8.2e-09 30.0 In-house 21-83 (305) alignment 
Range on Protein: 185-245
Range on HMM: 21-83/305.0
ETGIKAQFGLLHQVtPDPNDVHCNSAKAHATKNRSNKYLPPDKFIVALKEANG---YINASYLN
..|..||. .| .  ....||....|.... ..... .|..|..|.. || ..   ||||||..
dkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 295-400 1.3e-08 29.2 In-house 173-273 (288) alignment 
Range on Protein: 295-400
Range on HMM: 173-273/288.0
VIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
| .| . .|..|||  .  . |.... . .  ||    |.|||.|  | |.|    . | ||. . .  . . .. .  | ..  |..|  ||  .. ..
vkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv

DMYLQM
  .| .
leelll
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 333-394 1.7e-08 28.7 In-house 230-291 (297) alignment 
Range on Protein: 333-394
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||||.. .||..
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_PTPDC1_pd Subfamily PTPDC1 65-158 2e-08 28.9 In-house 85-170 (182) alignment 
Range on Protein: 65-158
Range on HMM: 85-170/182.0
YHLTSWPDHGVPEYGTPLMILHRQsnkSWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAkrervVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
..  .|.|.||.   . | |       . . ..| . ||| || ||||  ||  .   .      .. .  .. .|..| | .|| .|  ....
vynfgwkDygvasleriLdivkvv...afalqegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 294-399 5.4e-08 26.9 In-house 187-288 (305) alignment 
Range on Protein: 294-399
Range on HMM: 187-288/305.0
DVIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVV-DVFQVTKAVRRSKPGAVTTLEQYTSIYD
 | .    |||. ||     ..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  .. . .|  .  .. | .||  ...
kvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhq

VIDMYLQ
||  |..
vilnyfr
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 335-394 5.9e-08 27.0 In-house 2-61 (69) alignment 
Range on Protein: 335-394
Range on HMM: 2-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_CG42327_pd Subfamily CG42327 2-89 8.5e-08 26.2 In-house 103-190 (319) alignment 
Range on Protein: 2-89
Range on HMM: 103-190/319.0
VTNLKEGTKSKCEQYWPN--GRAESEEFGPFSVTLVDEQVLPDFVIRSITVMIQDGsNDSHTLTQYHLtSWPDHGVPEYGTPLMILHRQS
.|.| |    .| .|.|   .  . . .| . ||| . .|   ..| .. .   |. . |  || |    |.. .||   ..|. .  . 
ltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdk.eesrelthywy.kwleaevPaeeaaliamllev
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 61-165 8.9e-08 26.1 In-house 172-280 (303) alignment 
Range on Protein: 61-165
Range on HMM: 172-280/303.0
TLTQYHLTSWPDHGVPEYGTPLMI---LHRQSN-KSWSPSKGPILVHCSaGVGRTGTFIAIDIALEQAKRE-RVVDIAGIVNRLRQQRMKMVQTLDQYVF
 |  .|  .||   .|  |.| ..      ||  . .|.|. .. .  | |.||.|||  .. |    . |   .|.   .. .|. |.. || | |. .
flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls.gcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsv

LHDTVLEAII
..  . | ..
vytllaehvl
PTEN_1 60-116 9.2e-08 27.1 In-house 92-149 (196) alignment 
Range on Protein: 60-116
Range on HMM: 92-149/196.0
HTLTQYHLTSWPDHGVPEYGTPLMILhrQSNKSW-S--PSKGPILVHCSAGVGRTGTFIA
.   .|.  ...|||.|     . |.   | ..| .  |... .|||| ||.||.|| .|
ksgveylhfpieDhgapslselfdic..ksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 302-394 1.6e-07 25.3 In-house 176-265 (281) alignment 
Range on Protein: 302-394
Range on HMM: 176-265/281.0
DWPQDGVVREPRTVLQVIddvihRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEC-VVDVFQVTKAVRRS-KPGAVTTLEQYTSIYDVI
.||.  |      .|...     |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| . .  .| ||.||  |. |.
ewpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 335-395 2e-07 25.2 In-house 1-61 (69) alignment 
Range on Protein: 335-395
Range on HMM: 1-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| . 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 12-155 2.5e-07 24.5 In-house 149-293 (332) alignment 
Range on Protein: 12-155
Range on HMM: 149-293/332.0
KCEQYWPNGRAEsEEFGPFSVTLVDEQVLPDfvIRSITVMIQDGSNDSHTlTQYHLTSWPDH-GVPEYGTPL----MILHRQSNKSWSPSKGPILVHCSA
 | ..||. |.. ..|  .|.   |..      .... . . .  .| .|    |.  | |   .|||   .     . . .|.|      |||.. |..
icrkfwpekrsk.kdfpalsiqasddhseth..mktfnltvtekkqdhqt.vlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcat

GVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVF
|| .   . .||| . .   |. | .   .. .. ||.  ..|.  |  
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpyst
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 300-399 2.8e-07 24.3 In-house 188-286 (302) alignment 
Range on Protein: 300-399
Range on HMM: 188-286/302.0
VTDWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDMYLQ
.| |.|. |  .  .. . . .| . ..  .  ..|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|.||.|.| .. .|..
ltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 183-245 2.9e-07 24.7 In-house 3-66 (283) alignment 
Range on Protein: 183-245
Range on HMM: 3-66/283.0
LKETGIKAQFGLLHQVTPDPNDVHCNSAKAHATKNRSNKYLPPDKFIVALK-EANGYINASYLN
|. .. |...  |....  . |. ..||. . .||| .. .| |...| || |.. ||||... 
lrvnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfip
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 292-396 4.7e-07 23.8 In-house 214-342 (350) alignment 
Range on Protein: 292-396
Range on HMM: 214-342/350.0
SWDVIQLQVTDWPQDGVVREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC---------------KAECVVDVF
 . | ||||  |.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....   |..                 |.    ..
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

QVTKAVRRSKPGAVTTLEQYTSIYDVIDM
.. . .|. .   | .|.|.  ||. .  
iivnelrkqrismvqnldqfifiYeallf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 293-397 6.2e-07 23.4 In-house 188-288 (305) alignment 
Range on Protein: 293-397
Range on HMM: 188-288/305.0
WDVIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIGLEQCKA-ECVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
  | .|| |.||. ||     | |...  .  |  |.   |.|||||  . |.|   ..   ||.      .  . .. ||.|  .  .. .  ||  |.
msvrhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfih

DVIDMY
 |.  |
rvmlny
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 179-246 6.8e-07 23.3 In-house 8-80 (301) alignment 
Range on Protein: 179-246
Range on HMM: 8-80/301.0
TVQKLKETGIKAQFGLLHQVTPDPNDVHCNSAKAHATKNRSNKYLPPDKFIVALKEA-----NGYINASYLNE
 | . .......|.  |.........|................... ...|.. |..     . ||||||...
hvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 289-356 9.3e-07 22.5 In-house 214-290 (349) alignment 
Range on Protein: 289-356
Range on HMM: 214-290/349.0
DSSSWDVIQLQVTDWPQDGVVREPRTVLQV-------IDDVIHRQ--QKIGGGPVVVHCSDTVSRSGVYCSVSIGLE
 .. . ..|||| .|.  ... .| ..||        |||   |.  ..    ...||||    |.||.. . . |.
vekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 299-393 9.3e-07 22.7 In-house 196-285 (310) alignment 
Range on Protein: 299-393
Range on HMM: 196-285/310.0
QVTDWPQDGVVREP-RTVLQVIddviHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
.  .||. ||  |   || | .      |  .  ||.|||||  . | .| ... . ... .    ||. .|   ...|.   . |  ||. |  |
kwpnwpdrgvpdekchtvpqrl....laq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_eak_pd Subfamily eak 94-165 9.9e-07 22.4 In-house 234-306 (332) alignment 
Range on Protein: 94-165
Range on HMM: 234-306/332.0
SPSKGPIlVHCSAGVGRTGTFIAIDIA--LEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDTVLEAII
 ||  || . .. |  |.|.|. ||.   | ..|.. .  .  .. . ...|.. | .  |. |... ||. . 
ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 51-146 2.7e-06 21.2 In-house 218-320 (347) alignment 
Range on Protein: 51-146
Range on HMM: 218-320/347.0
MIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSWSPS-------KGPILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQR
.. .|  ..     |  |.|| .  |.    .. | |   |  |.|       . |..| |  |. |. | .   | .||    .  |   . ...|.||
vvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqr

MKM
  .
agv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 246-386 3.4e-06 21.0 In-house 130-269 (301) alignment 
Range on Protein: 246-386
Range on HMM: 130-269/301.0
ESCYQYWS--KTDSIKFGEYFVESTSHHDF--NGYTERKFHIRSDKDDSSSWDVIQLQVTDWPQDGVVREPRTVLQVIDdVIHRQQKigggPVVVHCSDT
| | .| .   ..... | . .. ....    .  ..|.....   .. ..  |.  | ..|.. || .    . .... .. . .|    |.|||||. 
ekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkksek....PivvhcsaG

VSRSGVYCSVSIGLEQCKAECVVDVFQVTKAVRRSKPGAVTTLEQ
. ||  . .  .   . .|.  ... .  | .|  .  .| | .|
iGrsvafigteylareveadptieltealkhlrehrwngvqtnsq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 185-250 3.6e-06 21.2 In-house 5-69 (267) alignment 
Range on Protein: 185-250
Range on HMM: 5-69/267.0
ETGIKAQFGLLHQVTPDPNDVHCNSAKAHATKNRSNKYLPPDKFIVALKE-ANGYINASYLNesCYQ
|. |. .| |....... . . .  |.  . .|| .. || |. .| |..  . ||||||..  .|.
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyve..gyk
subfamily_CDC14_pd Subfamily CDC14 95-119 5.5e-06 20.4 In-house 261-285 (328) alignment 
Range on Protein: 95-119
Range on HMM: 261-285/328.0
PSKGPILVHCSAGVGRTGTFIAIDI
 ..| | ||| ||.|||||.||  .
kaeGaiavhCkaGLGrtGtLiacyl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 181-246 5.6e-06 20.4 In-house 15-86 (290) alignment 
Range on Protein: 181-246
Range on HMM: 15-86/290.0
QKLKETGIKAQFGLLHQvTPDPNDVHCNSAKAHATKNRSNKYLPPDKFIVALKE-------ANGYINASYLNE
..  ..| ..||. |.. .  .. |. . ..   ..||.......| . . |..       .| ||||.|...
hakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikg
DSPc_SM00195 188-245 6.2e-06 21.1 In-house 2-63 (263) alignment 
Range on Protein: 188-245
Range on HMM: 2-63/263.0
IKAQFGLLHQVTPDPnDVHCNSAKAHATKNRSNKYLPPDKFIVALKEA-----NGYINASYLN
.|..|  | . |..  .....  |.  .|||....|| |.  | ||.      . ||||.|..
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyik
PTPc_SM00194 188-245 6.2e-06 21.1 In-house 2-63 (263) alignment 
Range on Protein: 188-245
Range on HMM: 2-63/263.0
IKAQFGLLHQVTPDPnDVHCNSAKAHATKNRSNKYLPPDKFIVALKEA-----NGYINASYLN
.|..|  | . |..  .....  |.  .|||....|| |.  | ||.      . ||||.|..
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyik
subfamily_ptpA1_pd Subfamily ptpA1 290-355 6.4e-06 20.1 In-house 183-253 (418) alignment 
Range on Protein: 290-355
Range on HMM: 183-253/418.0
SSSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIGL
  . |. | |   ||.  .    . . |..  .  ||..|        |..||||  | |.| .|.  | .
getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
DUF2480 Protein of unknown function (DUF2480) 100-193 7.6e-06 12.0 Pfam-A 65-156 (167) alignment 
Range on Protein: 100-193
Range on HMM: 65-156/167.0
ILVHCSAG-VGRTGTFIAIDIALEQAKRERVVdiaGIVNRLRQQRM-KMVQTLDQYVFLHDTVLeAIICGETEIPTENYMSTVQKLKETGIKAQFG
. ..||.  .  . ... . . ||.  .. ||   | .. |... . .....||   . . .|.    |.....|.. |.  .|||...  .  .|
valtCstdaivPaWayllvatelepfakkvvv...Gslellesvlyeeilekldlseykdkpvi.ikGCsdkpvPesayvlliqklqpvaksimyG
subfamily_PTPN23_pd Subfamily PTPN23 185-245 7.7e-06 19.9 In-house 14-76 (288) alignment 
Range on Protein: 185-245
Range on HMM: 14-76/288.0
ETGIKAQFGLLHQVT-PDPNDVHCNSAKAHATKNRSNKYLPPDKFIVALKE-ANGYINASYLN
.|.....| .|.|    . ..  .  || ...||||.  || |.  | |..  . |||||...
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvk
PTPc_motif_SM00404 95-117 8.1e-06 20.8 In-house 78-100 (140) alignment 
Range on Protein: 95-117
Range on HMM: 78-100/140.0
PSKGPILVHCSAGVGRTGTFIAI
 ..| .|||| ||| |..|.|. 
kkggkvlVHCqaGvSRSatliia
0048567 (Phosphotyrosine protein) phosphatases II 54-117 9.3e-06 20.1 In-house 25-97 (157) alignment 
Range on Protein: 54-117
Range on HMM: 25-97/157.0
DGSNDSHTL----TQYHLTSWPDHGVPE--YGTPLMILHRQSNKSWSPSKGPILVHCSAGV---GRTGTFIAI
.   . . .    . .... . |.| ..  . . ....  .  |...  ...| |||.||    |||.|.|. 
kslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 51-164 9.4e-06 18.4 In-house 196-309 (346) alignment 
Range on Protein: 51-164
Range on HMM: 196-309/346.0
MIQDGSNDSHTLTQYHLTSWPDHGVPEYGTPLMILHRQSNKSW-SPSKGpILVHCSAGVGRTGTFIAIDIALEQAKRERVVDIAGIVNRLRQQRMKMVQT
.. .|  ||     .| . |     |    |.. .  |        . | . |    | ||. .||    |..|       .|  |.  ..|||   |..
vlpegnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnag.vcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggves

LDQYVFLHDTVLEAI
. ||  ..  |.. |
faqyasiyaivfdyi