Gene PTPRD-66 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP124_AA protein Get Run
AqueP124_AA_898-1167 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 896-1167 7.4e-125 410.6 In-house 2-288 (301) alignment 
Range on Protein: 896-1167
Range on HMM: 2-288/301.0
LEDLNIHVTSCHSNGFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDF
||||..||...|||.||.||..||..|.|.|.||.|||||..||||.|||||||||||...||||.||||||||.|.||||..|||||.|||||||||||
ledlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdf

WRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFN--------------DSHTLTQYHLTSWPDH
|||||||||||||||||||||||.||| ||||. .|.||||||||.|...|..|||.||||.|.|||..|              .|....|...|.||..
WrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqd

GV-PDHATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|| ....| |...............||..||||..|.|.|......|.|||.|.| |||. ......|......|.||.||....|.
GvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 893-1167 2.9e-118 389.5 In-house 3-278 (305) alignment 
Range on Protein: 893-1167
Range on HMM: 3-278/305.0
PISLEDLNIHV---TSCHSNGFESQYTSLKSEeEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDmcQREYINANYVDGYSSSKKFIASQGPMK
.|.|.||. ..   .. ...|.| || || .| |... || .|.||  ||.|.||..||.||||.....||  ...||||.|||||...||.|..|||.|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATP
.|..||||||..||...|||.|.|.|| |.||. |||..  |..|||.|.| |.|..|..|.|.|.|...|.|  ..|.|..||.||.|||||||. || 
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

LMSLHKQVMATWSPSKG-PILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|.|| |.|. ... .|| |.||||||||||||.|||.|||||..|.| |||.......||..|||||||||||||||||
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhda
subfamily_PTPRD_pd Subfamily PTPRD 893-1167 2.3e-102 338.5 In-house 4-276 (564) alignment 
Range on Protein: 893-1167
Range on HMM: 4-276/564.0
PISLEDLNIHVTSCHSN---GFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLdmCQREYINANYVDGYSSSKKFIASQGPMK
||. ..|. || . ..|    ||..| ....... .. .   ..||. ||...|. || .|..| . ..    . .||||...||| ..|..||.|||..
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPla

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTlMeHEEFGPFTVLLQSTQTFPDFIIRQLCVtIQDVFNDSHTLTQYHLTSWPDHGVPDHATP
.|. ||||..|...  .|||.|.|.| .|.||. |||..   .|..| .|| |...... |..||.. .  .   ..|.. .|.| |||||||||..||.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesats

LMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|..| ..| |...| .|||.||||||||||||||..|. ||..| |..||| ..|..||.||  |||| .||.|.|.|
lLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFihea
0051299 (Phosphotyrosine protein) phosphatases II 911-1167 8.2e-89 293.1 In-house 25-281 (288) alignment 
Range on Protein: 911-1167
Range on HMM: 25-281/288.0
FESQYTSLKSEE-EKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNldMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
.. ..  | |     .. ... .||.. ||..||  ||..|..| . ..  .    ||||.|.||| ...|||| |||...|. ||||..|...   |||
lleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvm

VTNLKEGTKNKCELYWPNtlMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQD---VFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKG
.|.| |  ..||. |||.   .....|..|| | |.....|...|.|.||  |     . |.| |..| |.||||||||....|... ..|.   ....|
ltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasggg

PILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|..|||||||||||||||||..||| ..|..||. ..|.|||.||. ||||..||.|...|
pvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyea
0046845 (Phosphotyrosine protein) phosphatases II 911-1167 1.1e-87 289.4 In-house 2-269 (284) alignment 
Range on Protein: 911-1167
Range on HMM: 2-269/284.0
FESQYTSLKSEEEK---PCIVGYSEENKPFNRFKDITVYDDNRIILATNPNlDMCQREYINANYVDGY-----SSSKKFIASQGPMKKTLVDFWRLIWQE
.| ..  | |   |   .. |.. .||.  ||.||| .||..|..| . .. |.   .||||.|||||      ..||||| |||...|. ||||..|..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPVSIVMVTNLKEGTKNKCELYWPNTlMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWS
.   |||.|.| |  ..||. |||..  |  ..|.||| | |.....|...| |..|  .. . |.|.|..| |||||||||.....|... ..|    .
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

--PSKGPILVHCSAGVGRTGTFIALDIALEQAKRER---VVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
  |..|||.|||||||||||||||||..||| ..|.   .||. ..|.|||.||. |||||.||.|...|
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyea
0040438 (Phosphotyrosine protein) phosphatases II 907-1167 3.1e-87 288.1 In-house 16-271 (317) alignment 
Range on Protein: 907-1167
Range on HMM: 16-271/317.0
HSNGFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNldMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVS
  .......  | |    .. |.. .|||..||..||  ||..|..|   ..       ||||.||||.. ..|||| |||...|. ||||..|...  .
dftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IVMVTNLKEGTKNKCELYWPNtlMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQdVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKG
|||.|.|.|  ..||. |||.   |  ..|.||| |.|... .....|.|.|.     ..|.|.|..| |.|||||||.. ..| .. ..| .  ....|
ivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpgg

PILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|.||||||||||||||||....||| ..|. ||.  .|..||.||...|||..||.||.||
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0050432 (Phosphotyrosine protein) phosphatases II 910-1167 3.9e-87 287.7 In-house 43-294 (308) alignment 
Range on Protein: 910-1167
Range on HMM: 43-294/308.0
GFESQYTSLKSEE-EKPCIVGYSEENKPFNRFKDITVYDDNRIILatnpnlDmCQREYINANYVDGY--SSSKKFIASQGPMKKTLVDFWRLIWQEKPVS
..| ..  | |     .. |.. .|||..||.|||  || .|..|      |     ||||.|||||   ...|||| |||...|. ||||..|...   
lleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVMVTNLKEGTKNKCELYWPNTLM-EHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDvFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWspSK
|||.|.| |  ..||. |||..|  . .|.|.||| | |.....|...|.|..|  .  ..|.|.|..| |.|||||||.....|... ..|  .   ..
IvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg.dgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pg

GPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|||.|||||||||||||||||..||| ..|. ||. ..|..||.||. ||||..||.||..|
gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyra
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 905-1165 4.3e-86 283.4 In-house 16-276 (290) alignment 
Range on Protein: 905-1165
Range on HMM: 16-276/290.0
SCHSNGFESQYTSLKSEE-EKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEK
.   .||..|...|.| | |.   || ...||. |||..| |||||||.|   ..   |. ||||| |..||. .|..|| |||...||||||.||||||
akgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

PVSIVMVTNLKEGTKNKCELYWPNTlmEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHG-VPDHATPLMSLHKQVMATWS
   |||.|| .|  |.||  |||..  . ...|.|.. |.. .|. ..|.|.| |. ..  ......|||..|.|...| |....| |.......   . 
vtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrk

PSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
. ...|.||||..|||...|.|........| | |.|.  .....|.|....||| .|| ...
rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgif
0036941 (Phosphotyrosine protein) phosphatases II 923-1167 6.3e-86 283.6 In-house 28-272 (297) alignment 
Range on Protein: 923-1167
Range on HMM: 28-272/297.0
EKPCIVGYSEENKPFNRFKDITVYDDNRIILatnpnlDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCE
  .. |. ..||.. ||.|||  ||..|..|      |     ||||.|||||. ..|||| |||...|. ||||..|...  .|||.|.| |  ..||.
lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

LYWPNTLMEHEEFGPFTVLLQSTQT--FPDFIIRQLCVTIQDVFnDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGR
 |||..  |  ..|.||| |.|...  ..|...|.|.||  .   .|.|.|..| |.|||||||.....|... ..|      .||.||.||||||||||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

TGTFIALDIALEQAK---RERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.|||||.|..|.| .   .|. |||  .|. ||.||. .||||.||.||..|
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
subfamily_PTPRB_pd Subfamily PTPRB 892-1166 7.3e-85 279.5 In-house 5-279 (293) alignment 
Range on Protein: 892-1166
Range on HMM: 5-279/293.0
LPISLEDLNIHVTSCHS---NGFESQYTSLKSE-EEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPnlDMCQREYINANYVDGYSSSKKFIASQGP
 ||.||... ||.. ..    .|  .| .||.  ... . .  ...|.  ||...|  || .|. ||.    |  . .||||||..||.| ..|||.|||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyipgynsprefiatqGP

MKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHeEFGPFTVLLQSTQTFPDFIIRQLCVTIqdvFNDSHTLTQYHLTSWPDHGVPDHA
. .|. ||||..|..|   |||.|.| |. | ||| |||..  ..  .|  .| |.....  |..||.| ..     .......||| |||||||||...
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPekt

TPLMSLHKQVMATW--SPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
..|... ..|  .   . ||.||.|||||||||||||||||  |.. ..| .|||.||| .||..|. .||| .||.|.|.
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihq
0039614 (Phosphotyrosine protein) phosphatases II 899-1167 5.8e-84 277.3 In-house 22-284 (297) alignment 
Range on Protein: 899-1167
Range on HMM: 22-284/297.0
LNIHVTSCHSNGFESQYTSLKSEEEKpCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDMcQREYINANYVDGYSS-SKKFIASQGPMKKTLVDFWR
|. . .   ..... .. .|.|  .  . .....|||..||.|||  ||..|..| .... |.    ||||.|||||.  ..||||.|||...|. ||||
llllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

LIWQEKPVSIVMVTNLKEGTKnKCELYWPNTLMeheEFGPFTVLLQSTQTFPDFIIRQLCVTIqdvFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQV
..|...  .|||.|.|.|  . ||. |||..     ..|.||| | .... .....|.|.||     . |.|.|... |.|||||||.... |... ..|
mvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelv

MATWS--PSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.   .  |..||.||||||||||||||||....||| ..|. ||.  .|..||.||...|||..||.||.||
realaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0047943 (Phosphotyrosine protein) phosphatases II 922-1166 5.9e-84 277.1 In-house 26-266 (273) alignment 
Range on Protein: 922-1166
Range on HMM: 26-266/273.0
EEKPCIVGYSEENKPFNRFKDITVYDDNRIILatnpnlDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKC
.. .. |.. .||| .||.|||  ||..|..|      ..    ||||.||||| ...|||| |||...|. ||||..|...   |||.|.| |  ..||
plltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekc

ELYWPNTLME-HEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDvFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSP--SKGPILVHCSAGVGR
. |||..  | ....|.||| | |..|..|...|.|..|  . ...|.| |..| |.|||||||.. ..|... ..|. . .   |.||..|||||||||
aqYwpleggelsltygkftvtllseetkddytvrtleltnlg.tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgR

TGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
||||||||..|.| ..|. ||.  .|..||.||. ||||..||.||..
tgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
0045450 (Phosphotyrosine protein) phosphatases II 908-1167 1.1e-83 276.8 In-house 26-299 (307) alignment 
Range on Protein: 908-1167
Range on HMM: 26-299/307.0
SNGFESQYTSLKSEEEK---PCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLdMCQREYINANYV--------DGYSSSKKFIASQGPMKKTLVDFW
 .|.. .. .|.|.. .   .. .....|||..||.|||  ||..|..| . ..  .    ||||.||        ||| ...|||| |||...|. |||
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

RLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTlMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQ
|..|...   |||.|.|.| ...||  |||..  |. ..|.||| | |... .....|.|.||  |  . |.|.|..| |.|||||||..  .| .. ..
rmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

VMA--TWSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERV---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|..   ..|..||.||||||||||||||||....|.| ..| .   ||.  .|..||.||...||...||.||..|
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 905-1167 3.9e-83 274.4 In-house 16-272 (278) alignment 
Range on Protein: 905-1167
Range on HMM: 16-272/278.0
SCHSNGFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNldMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKP
     ... .. .| |    .. .....|||..||.|||  || .|..|   ..       ||||.|||||. ..||||.|||...|. ||||..|... 
lnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

VSIVMVTNLKEGTKNKCELYWPntlMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIqDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPS
 .|||.|.|.|  ..||  |||    .....|.||| |.......|...|.|.||     . |.| |.|| ..|||||||.. ..|... |.|.   ..|
ttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealeds

KGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.||.|||||||||||||||||...|||...|. ||.  .|..||.||...|||..||.||..|
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 908-1166 4.7e-83 273.5 In-house 19-272 (287) alignment 
Range on Protein: 908-1166
Range on HMM: 19-272/287.0
SNGFESQYTSLKS--EEEKPCIVGYSEENKPFNRFKDITVYDDNRIILAtnpnldMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPV
..||. |.| |..  ..|.   .. ...||. ||...| |.|..|..|        .. .|||| ..|||...|.||....|| .|...||.||..... 
negfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvt

SIVMVTNLKEGTKNKCELYWPNTLMehEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHG-VPDHATPLMSLHKQVMATWSPS
 |||....|| ....|  |||..      .|.... | . ..  ..|.|.| |. ..  .| ....||..|.|...| |....| |. ..... .   ..
aivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg

KGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
...|.||||..|||...|.| .......|.| |.|.  .... |.|....||| .|| |. |
ntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfind
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 894-1167 9.8e-82 269.5 In-house 2-275 (318) alignment 
Range on Protein: 894-1167
Range on HMM: 2-275/318.0
ISLEDLNIHVTSCHSNG---FESQYTSLKSE-EEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPnlDMCQREYINANYVDGYSSSKKFIASQGPMK
||.|||. ||   ...|   ....|  |. . |.   .   .. ||  ||. .|. ||. |. | .    .  . .||||||.||| ..|..||.|.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmle..geegsDyinanyidGyrrkkayiaaqaPlp

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTlmEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVfNDSHTLTQYHLTSWPDHGVPDHATP
.|. ||||..|. .   |||.|...| .|.|.. |||.   . ...|  .| |... .. |...|.. || ... ..| .  ||| |||||.|||.... 
etieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrtee.eesrqvrqyhytsWpdegvpesgas

LMSLHKQVMATW-SPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|..| .|| ..  ....|||.|||||||||||.|||.|| ||..| | .||. ..|..||.||  |||| |||.|..|.
lldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydv
DSPc_SM00195 911-1167 1.2e-81 269.3 In-house 2-257 (263) alignment 
Range on Protein: 911-1167
Range on HMM: 2-257/263.0
FESQYTSLKSEE-EKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLdmCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
.. ....|.... .|..  .  ..||  ||.|.| .||..|..| ....    . .||||||..|....||.|| |||...|. ||||..|.||   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFP-DFIIRQLCVTIQDVfNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKGPI
.|. .|  |.||. |||..  . |.|| ..| |..... . ..|.|.| .| ..  ......|||. ..||||||||.......| ..|  . | |.|||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.|||||||||||||...||.|.. ..|  |||  ||..||.||..|||||.|| |...|
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyea
PTPc_SM00194 911-1167 1.2e-81 269.3 In-house 2-257 (263) alignment 
Range on Protein: 911-1167
Range on HMM: 2-257/263.0
FESQYTSLKSEE-EKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLdmCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVM
.. ....|.... .|..  .  ..||  ||.|.| .||..|..| ....    . .||||||..|....||.|| |||...|. ||||..|.||   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFP-DFIIRQLCVTIQDVfNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKGPI
.|. .|  |.||. |||..  . |.|| ..| |..... . ..|.|.| .| ..  ......|||. ..||||||||.......| ..|  . | |.|||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.|||||||||||||...||.|.. ..|  |||  ||..||.||..|||||.|| |...|
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyea
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 906-1166 3.9e-81 267.2 In-house 18-273 (288) alignment 
Range on Protein: 906-1166
Range on HMM: 18-273/288.0
CHSNGFESQYTSL-KSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDmcQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKP
   .||...| || . |..|   .|   .|.. ||...|  || .|. |   .. .  . .||||.|.||. ..||.||.|||. .|. |||.|....| 
rnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkt

VSIVMVTNLKEGTKNKCELYWPNTlMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTiqdVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPS
  |||.|.| || |.||| |||..  .....| .|| |.....  ||. |.| .      ..  ..|||. ..|||||||. ..||. | .||  . .  
stivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

KGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
 |||.||||||||||||||||| .... ..| ..|.||.|..||.||. .|||| ||.|...
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiye
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 893-1167 3.9e-80 264.3 In-house 4-278 (319) alignment 
Range on Protein: 893-1167
Range on HMM: 4-278/319.0
PISLEDLNIHVTSCHSNG---FESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNldMCQREYINANYVDGYSSSKKFIASQGPMK
.| ...|. ...  .|.|   .| ..  ||  ...       ||||. ||...|  ||  |..|.. ..  . . .||||...|||   .|||| |.|..
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqaPle

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTlmEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATP
.|. ||||..|.|.   .||.|.|.|  | |.. |||..  ..||.| ..| |.. .   |.|||.|.. ..    .. ...... |.||||.||..|| 
ntiedfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

LMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|. | |..  ...  ..||| ||||||||||||||.||..||. |.| |.|.  .|.||| ||  |||. .|| |...|
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyea
subfamily_PTPRG_pd Subfamily PTPRG 896-1167 4.9e-78 257.7 In-house 3-282 (563) alignment 
Range on Protein: 896-1167
Range on HMM: 3-282/563.0
LEDLNIHVTSCHSNG---FESQYTSLKSEE---EKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDMCQrEYINANYVDGYSSSKKFIASQGPMK
..... ||.|.|..|   |. .. .|.||    . ..     .|||  ||  .|. ||  |. |.  |. .    .||||||.|||  ||.|||.|||.|
vkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgplk

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNtlMEHEEFGPFTVLLQSTQT-----FPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVP
.|. ||||.||...   |||.|||.| ...||. |||.   | |..| ..| |.....        ..|..| .  ..  .. .. .||| |.|||||||
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

DHATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.|..| ..  |.  |.     |||.||||||||||||.|.||  |.| ..| .|.. |.. ..| ||  .||| .||.|||||
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhda
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 906-1167 5.7e-78 257.2 In-house 24-285 (298) alignment 
Range on Protein: 906-1167
Range on HMM: 24-285/298.0
CHSNGFESQYTSLKSEEE----KPCIVGYSEENKPFNRFKDITVYDDNRIILATNPnlDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQ
 .  |.....  |.| ..    .   |. ..|||  ||. ||  .|  |..| ..   .  . .|||| ....|. .. |||.|.|...|..||||....
kkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvte

EKPVSIVMVTNLKEGTKNKCELYWPNTlmEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFnDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMAtW
|.  .|||.|||.|  | |.. |||..  ..|..| .|| |.|...| |.|.|.| |. ...  ..... | | |||||.||| .|| .. | ..| | .
edigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.s

SPSKG--PILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
    |  |..|.|||||||.|||||.|  ||..|.|.|||.  .|..||..|...||| .||||...|
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyea
Y_phosphatase Protein-tyrosine phosphatase 934-1167 1.3e-77 255.7 Pfam-A 1-232 (235) alignment 
Range on Protein: 934-1167
Range on HMM: 1-232/235.0
NKPFNRFKDITVYDDNRIILatnpN-----LDmcqreYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNT
||  ||.|||..||..|. |    .      |     |||||||.||...|||||.|||.|.|. ||||..||||  .|||.|.|.|  ..||. |||..
nkkknRykdilpydktrvkl....kgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

LMEHEEFGPFTVLLQ-STQ-TFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIALD
  | ...| ..| |. ...    ....|.| .. ..  .......|.|.|.|||||||.....|..| ..|  . ....||..|||||||||||||.|||
eeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald

IALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|.|||...|. ||.  ||..||.||..|||.|.||.||..|
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka
Y_phosphatase Protein-tyrosine phosphatase 934-1167 1.3e-77 255.7 In-house 1-232 (235) alignment 
Range on Protein: 934-1167
Range on HMM: 1-232/235.0
NKPFNRFKDITVYDDNRIILatnpN-----LDmcqreYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNT
||  ||.|||..||..|. |    .      |     |||||||.||...|||||.|||.|.|. ||||..||||  .|||.|.|.|  ..||. |||..
nkkknRykdilpydktrvkl....kgsegpsd.....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

LMEHEEFGPFTVLLQ-STQ-TFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIALD
  | ...| ..| |. ...    ....|.| .. ..  .......|.|.|.|||||||.....|..| ..|  . ....||..|||||||||||||.|||
eeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald

IALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|.|||...|. ||.  ||..||.||..|||.|.||.||..|
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka
0040439 (Phosphotyrosine protein) phosphatases II 925-1167 3.5e-77 254.7 In-house 2-241 (249) alignment 
Range on Protein: 925-1167
Range on HMM: 2-241/249.0
PCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDMCQreYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELY
.. |.. .|||. ||..||  || .|..|   |.|  .   ||||.|.||| ....||| |||...|. ||||..|...  .|||.|.|.|  ..||. |
eysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPNtlMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQdVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTF
||.   .. |.| ||| | |.....|...|.|..|    ...|.| .... |.|||||||..  .|... ..|.   .. |..||.||||||||||||||
wpl..ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

IALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
||....||| ..|. ||.  .|. ||.||...||...||.||..|
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
subfamily_Ptp69D_pd Subfamily Ptp69D 902-1167 8.6e-77 253.3 In-house 12-281 (307) alignment 
Range on Protein: 902-1167
Range on HMM: 12-281/307.0
HVTSCHS---NGFESQYTSLK-SEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDmcQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWR
 ..| .     |..  | .|. .| .| . |.  .||.  ||..||. .|..|..|.. .  .  . .||||... ||  .|||||.|.|.  |. ||||
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveatigDfWR

LIWQEKPVSIVMVTNLKEGTKNKCELYWPNTlmEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQD--V--FNDSHTLTQYHLTSWPDHGVPDHATPLMSL
.|.. .   |||..||.| ...||. |||.   .  ..|   | | |... .|.|||.| |. ..  .   .||. ..||| |.|.|  ||..|. |. |
miaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkl

HKQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
 .||    . ...||.|||||||||.|.|.|||. |.| | |  |||  .|  ||.||  .|| |.|||||. |
ieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyra
0045098 (Phosphotyrosine protein) phosphatases II 925-1167 4.8e-76 251.1 In-house 24-267 (278) alignment 
Range on Protein: 925-1167
Range on HMM: 24-267/278.0
PCIVGYSEENKPFNRFKDITVYDDNRIIlatnpnldmcqrEYINANYVDGYssSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELY
 . ..  ..|...||.|||  || .|..            .||||.|.|||  .||||| |||...|. ||||..|...  .|||.|.|.|....||. |
eitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPNtlMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQ---DVFNDSHTLTQYHLTSWPDHGVPDHA--TPLMSLHKQVMATWS-------------PSKG
||.  ......|.||| |.|.....|...| | ||     .  . |...|..|...|||||||..   ... .| ... .  .             .|.|
wpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PILVHCSAGVGRTGTFIALDIALEQAkrERVVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDA
|.|||||||||||||..|... ||.   |..||.  .|. ||.||.  .||.|.||.||...
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyef
subfamily_PTPRA_pd Subfamily PTPRA 898-1166 1.3e-75 249.3 In-house 22-289 (330) alignment 
Range on Protein: 898-1166
Range on HMM: 22-289/330.0
DLNIHVtSCHSNGFESQYTSLKS-EEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDmcQREYINANYVDGYSSSKKFIASQGPMKKTLVDFW
...|.. .  .. |  .. .| . . .  . .   ||||  ||. .|  || .|.||..    .  . .|||| ..|||   .||||.||| ..|. |||
eirirs.addnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaqGPkeetvedfw

RLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMehEEFGPFTVLLQSTQTFPDFIIRQLCVT-IQDVF--NDSHTLTQYHLTSWPDHGVPDHATPLMSL
|.||. |  .|||.|.|||  ..||. |||.  .    .|  .| .. ..   |. .|...|. . |    ..|  ..|.|.||||| ||| ..  ...|
rmiweqksativmltelkerkeekcaqywPdeGl..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkl

HKQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
 |.| ..   | ||| ||||||||||||||.||  ||. | ||.||. ..|.|||.|| .||||. ||.|.. 
lkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiyk
subfamily_PTPRK_pd Subfamily PTPRK 896-1167 5.1e-75 247.2 In-house 6-272 (314) alignment 
Range on Protein: 896-1167
Range on HMM: 6-272/314.0
LEDL--NIHVTSC-HSNGFESQYTSLKSEeekpCIVGYSEENKPFNRFKDITVYDDNRIILATNpnLDMCQREYINANYVDGYSSSKKFIASQGPMKKTL
 .||  .| .  . .. ||  .| ||         .   .||.  ||..||  ||  |..| |    .  . .||||...|.|  ...||. |||...|.
vadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvfliti..dgdpssdyinaalidsykrpaafivtqgPlqetv

VDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNtlmEHEEFGPFTVLLQSTQTFPDFIIRQLCVTI-QDVFNDSHTLTQYHLTSWPDHGVPDHATPLM
 |||||...|.  ||||.|.|.| .. ||  |||.   . | .|.. | | .|..  ....| . |.  .   .. ... |.. ..||||.|| .|| |.
kdfWrlvydencasivmltelvevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgll

SLHKQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.| ..| ..  ...|.|.|||||| ||||||||.|| |. ..||.|||.  .|  ||.... ||.| .||.|..|.
klvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydv
subfamily_PTPN12_pd Subfamily PTPN12 915-1167 7.6e-75 246.5 In-house 21-272 (290) alignment 
Range on Protein: 915-1167
Range on HMM: 21-272/290.0
YTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDmcQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLK
 . .|.|.. .  .| .|||.  ||.|||  || .|. | .. . .  . .|||||.. | ......||.|||. ||| ||||.||. .   .||. .. 
sekykaekvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrev

EGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFP-DFIIRQLCVTIQdvfNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKGPILVHCS
|  |.||| |||..  |. |||.|.| |.. ...  ||.||.| |. |   ..|....|.| |.|||||||  |..|..| ..|  . . .. |..||||
elgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCs

AGVGRTGTFIALDIALEQAKRERV---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|||||||| ||.|.. |. |.|..   .|.  .| .||.||  .||| .||.... |
aGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvyka
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 893-1167 3.1e-74 244.7 In-house 5-274 (315) alignment 
Range on Protein: 893-1167
Range on HMM: 5-274/315.0
PISLEDLNIHVT---SCHSNGFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDmcQREYINANYVDGYSSSKKFIASQGPMK
|| |..|  .|.   .   |||. .| |.   . .|  |    |||  ||. .|  ||  |. |    | .  . .|.|||..|||.  ...||.|||  
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendp..hsdyvnanfidGynkkrryiaaqgpnv

KTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTlmeHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFndsHTLTQYHLTSWPDHGVPDHATP
 .. |||||...|.   |||.||| || |.|.| |||.    .  .|..|| ..| . . .. .| | |. .|     ... |.|.||||| ||| ...|
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdni...revvqlhytswpdmgvpkytip

LMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|| |...|.     | |.|.||||||||||||||.||  |.||. |...|.  .....||.|.||||...|| |..||
lmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda
0042113 (Phosphotyrosine protein) phosphatases II 930-1167 5.7e-74 243.9 In-house 5-238 (245) alignment 
Range on Protein: 930-1167
Range on HMM: 5-238/245.0
YSEENKPFNRFKDITVYDDNRIILATNPNLDMCQreYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNtl
. .|||..||..||  ||..|..|   ..   .   ||||.|||||  ..||||.|||...|. ||||..|...  .|||.|.. |  ..||. |||.  
llpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

MEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIqDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWS-PSKGPILVHCSAGVGRTGTFIALDIA
 |. ..| ||| | |.....|...|.|.||  .  . |.. ..|| ..||||||||.   | .... |    . .|.||.||||||||||||||||....
gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
|||...|. |..  .| .||.||...|||..||.||..|
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 930-1166 2.4e-73 241.4 In-house 5-236 (250) alignment 
Range on Protein: 930-1166
Range on HMM: 5-236/250.0
YSEENKPFNRFKDITVYDDNRIILATNPNLDMCqrEYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNkCELYWPNTl
   .||  ||. ||  .|  |..| ..   . .  .|||| ...||. .| |||.|||...|..||||....||  .|||.|||||  |. .. |||   
kkpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve.

mEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVfNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIALDIA
 . |..|  || | |...| |...|.| .. .   .|. .. |.| ..||| |||..||  . | |.| |.     ..|..|.|||||||.|.|||.|  
.kaekyGdvtvsllskeefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

LEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
||..|.|.|||.  ....||..|...|..|.||||.. 
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvye
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 904-1167 1.4e-72 239.4 In-house 13-271 (515) alignment 
Range on Protein: 904-1167
Range on HMM: 13-271/515.0
TSCHSNGFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPnlDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEK
 . |   |  ..  |   .  |  |   | | . ||.|.|  || .|..|      |  . .|.|| |. .. . | .|||||| | .. |||||..||.
knrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqen

PVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDvfnDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSP
.  |.|||.|||| | ||  |||.   .  .|| . | | |...  . |.|.| |. .|   ||.|.||.|.| |||.||| |.. |. | |.| |  . 
vttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgd...dsrtvtqfhfteWPdkGvpkhtssllklikevkadhgq

SKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
 . |...|||||||||| .|..|  . .||  |.||.  .|. .||.|...||| .|| |...|
ythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiyga
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 907-1166 3.7e-72 237.8 In-house 13-270 (281) alignment 
Range on Protein: 907-1166
Range on HMM: 13-270/281.0
HSNGFESQYTSLKS-EEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDmcQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPV
...|| ..|..|.. . ...    ...||.  ||...|. ||  |. .. | .    . .|||||.|.||.. |..||.|||. ..||.||...|..|  
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

SIVMVTNLKEGTKNKCELYWPNTLMeHEEFGPFTVLLQSTQTFPDFIIRQLCVtiQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPS-
 |||||.  |. | ||  |||.    . ..| .||  ..... . .| |.. .  .   ... ...| . |.|||||||. .. |.. .|.|. . ... 
aivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekkt

KGPILVHCSAGVGRTGTFIALDIALEQAKRE-RVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
| |...|||||||||||.|||| .......| . .|.  .|. ||..|. ||||. || |.. 
kaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvyk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 905-1167 1.9e-71 235.5 In-house 15-272 (315) alignment 
Range on Protein: 905-1167
Range on HMM: 15-272/315.0
SCHSNGFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPnlDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKP
  |.  |  ..  |   .  .  |.  ..| . ||.|.|  .| .|..|      |  ...|||| |. .. . | .|||||| | .. ||||...|||.
nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevid..dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekv

VSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLcVTIQDvfNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPS
 .|||||...|| | ||  |||.   .  ||| . | | |...  | ..|.| || .   ..|.|.||...| |||.||. ... |. | |.| |   . 
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrks..eesrtvtqfqftewPdkGvdkqtssllklikevkadngkk

KGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
. ..|||||||||||| .|..|  ..|.||.|.||.  .|. ||..|...||| ..| |..||
efsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiyda
subfamily_PTPN6_pd Subfamily PTPN6 897-1166 8.9e-71 233.4 In-house 14-291 (306) alignment 
Range on Protein: 897-1166
Range on HMM: 14-291/306.0
EDLNIHVTSCHSNGFESQYTSLKSEEEKPC---IVGYSEENKPFNRFKDITVYDDNRIILAtnpNLDMCQREYINANYVDG--YSSSKKFIASQGPMKKT
..|. . .| . .||| .. .|. ||.|       |   |||  ||.| |  .|..|.||.   . .. . .||||||...   .|.|..||.|| ...|
selekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclett

LVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEeFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLM
. ||||..|||.   |||.|.  | .|.||  |||.. ...| .|  .|   | ..  |.|.|.| |. ..  ...... ||| .|||||||| .   ..
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL

SLHKQVMATWSPSK----GPILVHCSAGVGRTGTFIALDIALEQAKRER---VVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
.. ..| .  . ..    |||.||||||.||||||| .|| |.. ...     .||  .|. .|.||  .||| .|| |.. 
dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvyk
0037934 (Phosphotyrosine protein) phosphatases II 926-1167 1.1e-70 233.3 In-house 2-237 (243) alignment 
Range on Protein: 926-1167
Range on HMM: 2-237/243.0
CIVGYSEENKPFNRFKDITVYDDNRIILatnpnlDMcqREYINANYVDGYsssKKFIASQGPMKKTLVD----FWRLIWQEKPVSIVMVTNLKEGTKNKC
. .. ..||.. ||..||  ||..|..|      .     |||||.....   ...||.|||...|. |    |||..|...  .|||.|.|.| ...||
fsiallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekc

ELYWPntlmEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMAT--------WSPSKGPILVHCS
. |||    . ...|.||| | |.....|...| |...  |  . ... ..|| ..||||||||. ..|......| .           .|.||.|||||
aqywp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

AGVGRTGTFIALDIALEQAkreRvVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDA
||||||||.||... |..    . ||.  .|..||.||.  .|||..||.||..|
aGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyea
subfamily_PTPN9_pd Subfamily PTPN9 896-1166 3.2e-68 224.9 In-house 3-284 (297) alignment 
Range on Protein: 896-1166
Range on HMM: 3-284/297.0
LEDLNIHVTSCHSNGFESQYTSLKSEEEKPCI-VGYSEENKPFNRFKDITVYDDNRIILATNPNLDmcQREYINANYVDGYSSSKKFIASQGPMKKTLVD
.|.|  .| . . .|   .|. ...|. .  . .  .  |   ||..|.  ||. |. ||. .. .  . .|||||.||||   | ||| |||.|||  |
ieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsd

FWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDvFNDSHTLTQYHLTSWPDHGVPDHATPLMSLH
|||..|... . |||.| . |  . ||  |||..  . .||| ..|   ....  |. .|.| ..  .  ..| ..| . ..||||.|||. |. |. . 
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvl

KQVM-----------AT--WSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
..|            ..    ||. ||.||||||.|||||||.|||.|.. ... .||.   |..||.||  ..|| .||.| . 
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 922-1166 4.4e-67 221.0 In-house 20-262 (274) alignment 
Range on Protein: 922-1166
Range on HMM: 20-262/274.0
EEKPCIVGYSEEnkpfNRFKDITVYDDNRIILATNPNLdMCQREYINANYVDGYSS-SKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNK
.|.. . | ..     ||.|.|   .  |..| .. .    . .||||||. ||.  || ..| |||. .|. ||||.|.||.   |||.|.|||  ..|
qeeldvfgsqtk....nryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqk

CELYWPNTLME--HEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVfndSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPS---KGPILVHCSAG
|. |.|..     .|..| . .  ... .  |. .|.| .  .     ..... |  |.|||| .||.|..|..| ..|  . . .    .|..||||||
CavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

VGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
.|||| ||| .||. | ..| |||. .||  ||..|  |||| .|| ..| 
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 932-1167 2.5e-65 215.9 In-house 59-286 (319) alignment 
Range on Protein: 932-1167
Range on HMM: 59-286/319.0
EENKPFNRFKDITVYDDNRIILATNpnLDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKNKCELYWPNTLME
..||  ||. .|  .| |.. |       .   .|||| .|.|| . .|.||.|||.. || ||||.||. .  .||..|      |.||  |||.   .
dqnkdknriinilafdknvvklerl..iGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

HEEfgPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMAT--WSPSKGPILVHCSAGVGRTGTFIALDIAL
.||   | | ..| .   ....|.. .. .   .|   .||.|.  |||.||||....|| | |.|         . .|.|||||||||||..|.||. |
kee..rfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvll

EQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.. |.|. ||.  .|. ||||| ..|| | || |.. |
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 910-1167 9.6e-65 213.3 In-house 7-261 (283) alignment 
Range on Protein: 910-1167
Range on HMM: 7-261/283.0
GFESQYTSLK--SEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNldmcqrEYINANYVD---GYSSSKKFIASQGPMKKTLVDFWRLIWQEKP
... ..  ||  |  .... .  ..|||..||...| ..| .|. | ....      .|||| ..     |  .||.|..|.|...| ||||.....|| 
nnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

VSIVMVTNLKEGTKNKCELYWPNTlmEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPS
..|||.|.|.|. . ||  |||.     |..|.||| |.   |   |||..| .  .   ...  |. | .  | . |       |. . | .       
taivmltklqedlrikCsqyWPkr..GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtesk

KGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
||||.||||.|.|||..|||.  ....|. | |||.  .|. .|.||| .||||||| ..|..
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhel
subfamily_PTPN3_pd Subfamily PTPN3 927-1166 1.6e-64 212.6 In-house 34-269 (280) alignment 
Range on Protein: 927-1166
Range on HMM: 34-269/280.0
IVGYSEENKPFNRFKDITVYDDNRIILATNPNlDmcqreYINANYVD----GYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCE
 .    || . ||..||. ||. |..|  ... |     |||||||.    . . ....||.|||..||  |||...|..|   |||.|.| |  . || 
saarkpenlsknryrdilpydatrvklkeset.d.....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

LYWPNtLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVfNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTF
 |||.   .. |.| |.| ......   ...|.|... ..  .......|   ..||||||||... .... ..| .. | .. |..||||||.|||| .
qyWPe.tedeleygefsvkcekedetksyvlrelvlkdket.keerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvl

IALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
|.|..||    ... | .  || ..|.||. .||| .|| |. .
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCe
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 932-1167 2e-64 212.8 In-house 23-250 (284) alignment 
Range on Protein: 932-1167
Range on HMM: 23-250/284.0
EENKPFNRFKDITVYDDNRIILATNpnLDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtKNKCELYWPNTLME
..||  ||. .|  .| |.. |       .   .|||| .. || . .|.||.|||.. || ||||.||. .  .||..|      |.||  |||.   .
dqnkdknrighilafdknvvklerl..iGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

HEEfgPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIALDIAL
.||   | | ..| .   ....|.. .. .   .|  ...|.|.  |||.||||....|| | |.|    .    . .|.|||||||||||..|.||. |
kee..rfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvll

EQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.. |.|. ||.  .|. ||||| ..|| | || |.. |
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 907-1167 1e-63 210.5 In-house 21-283 (325) alignment 
Range on Protein: 907-1167
Range on HMM: 21-283/325.0
HSNGFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPnlDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLI--WQekp
  .||  ..  | |.. .   |    |||  ||||..  .| .|..| |    |  . .||||.|.  .   . |.|.| |. .|. |.|||.  |.   
dqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkk..ddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...

VSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTiqDVF-NDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVM-----
 |.|.|.|  .. |..|  |||. . .  .||.. | |.. ... |.. |.| |   .|   .. .. |..| ||.| ||. . . |.|. . |      
csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvk..qvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

-ATWSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
  . . . .||||||||||||||.||.|  ||..   |  ||| | |..||..| .||.| |||.....|
vtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyea
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 893-1166 1.1e-61 203.6 In-house 9-278 (297) alignment 
Range on Protein: 893-1166
Range on HMM: 9-278/297.0
PISLEDLNIHVT-SCHSNGFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPnlDMCQREYINANYVDGYSSskKFIASQGPMKKT
|| | |..  |  . |.. |. ..  | . . .|  |     | . .|.|.|  || .|..||     |  . .|.|| .| |.    ..|..| ||| |
piplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqmPmkat

LVDFWRLIWQEKPVSIVMVTNLKEGTKnKCELYWPNTLMEHeeFGPFTVLLQSTQTFPDFIIRQLCVTIQDVfNDSHTLTQYHLTSWPDHGVPD--HATP
. |||.....|..  |||.....|..| ||  ||... .    ||  .|.|.|..    || |.| || ..     . . ||. ..|||. |.   .|. 
vadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgka.karrvvkqyqfveWPdkaverkdsass

LMSLHKQVMATWSPSKG-PILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
|. | ..|  ..|  .  |.||||.||||||| ....|  . .||||  ||| |.|..|||.|...||| .|| |.. 
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 919-1166 1.1e-61 203.2 In-house 5-258 (270) alignment 
Range on Protein: 919-1166
Range on HMM: 5-258/270.0
KSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNldMCQREYINANYVDGYSSS-KKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGT
. ||...  .     .| .||..||      |..|..  .    . .||||||| |.... ||.||..||.. || .|||.||.||  .|||.|.|.|  
dkeetsesdlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkg

KNKCELYWPNTLME--HEEFGPFTVLLQSTQTFPDFIIRQLCVTiqdVFNDSHTLTQYHLTSWPDHGVPDHAT------PLMSLHKQVMATWS-PSK-GP
..||| |||.   |  . |.|  .|| .|..    .|...| ..      ... |. .. ..||||||| ..        |... ..| .. .  .| .|
rkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaeP

ILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
.|||||||||||||.||||||..  .... ||.. |...||..||..||. .|| ||. 
llvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflyk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 933-1166 1.4e-61 202.8 In-house 2-233 (237) alignment 
Range on Protein: 933-1166
Range on HMM: 2-233/237.0
ENKPFNRFKDITVYDDNRIILATNPNLdmcqREYINANYVDGYSS-SKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLmE
|||  ||. .|..|| .|..|  . .      .||||.|..|.    ||.||.|||.. .  |||...||||   |||.| | || . ||  |||.|  .
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.q

HEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMAT--WSPSKGPILVHCSAGVGRTGTFIALDIAL
 . .| .|| |.  . | |. .| | .. .   ..   . ||..|||||.|||.... |. . |...      .  || ..|||||||||| |. .|  |
paaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

EQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
 ||| ..||||   |  . ..|  ..|| |||||.|.
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 931-1167 8.4e-61 200.7 In-house 45-274 (439) alignment 
Range on Protein: 931-1167
Range on HMM: 45-274/439.0
SEENKPFNRFKDITVYDDNRIILATNPNLdmCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKnkcelYWPNTlm
 | ... ||.||.. .|  |..|   | .   .  ||||||..||   | .||.||| |.|  |||||....| | |||.||| |  |     |||    
qeydqtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd..

EHEEFGPFTVLLQSTQTFPDFIIRQLCVT-IQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQV-MATWSPSKGPILVHCSAGVGRTGTFIALDIA
..  .|  .|  .    .|...|| . |   .|  .  .|. |.| ..|||. || .|. .. . . .  |  .   ||..|||||||||||| ||||||
aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdia

LEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
||| | |  ||| |||. ||.|| .|||.| ||||...|
leqlklenkvdikgivkvlrkqrkqmvqalcqyvfiyna
subfamily_PTPN13_pd Subfamily PTPN13 923-1166 2.5e-60 199.1 In-house 26-263 (273) alignment 
Range on Protein: 923-1166
Range on HMM: 26-263/273.0
EKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNldmcqreYINANYVDGYSSSK--KFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNK
 . | || ..|||  ||....  ||. |..|  . .       ||||...      .  ..||.|||. .|  |||...|. |   |.|||. ||. | |
ldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk

CELYWPNTLMEHEEFGP-FTVLLQSTQTFPDFIIRQLCVTIQDvFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQvMATWSPSKGPILVHCSAGVGRT
|. |||..  ..      ..| |  .|   .| .|.| |. ..  ..|. ... ....||||||| .|..|. . .. ...   ..|||.||||||.||.
chrywPesknkklkvsnrlevellkvqkldgfvvralavkdse.sgesrevahlnfvkwPdhgvPssaaellqfvae.vrrlqtdagPivvhcsaGiGrs

GTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
||.|..|..|.  .|.. .|.  ||..||.||  .||| |||.| . 
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 934-1166 3.6e-59 194.8 In-house 7-234 (239) alignment 
Range on Protein: 934-1166
Range on HMM: 7-234/239.0
NKPFNRFKDITVYDDNRIILATNPNldMCQREYINANYVDGYSS-SKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMeh
||  ||. .|  || .|..|    |    . .||||.|.  |    | .||.|| .. .  ||||..|||. . |||.| | || |.||  |||..    
nkaknryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

eEFGPFTVLLQSTQTFPDFIIRQLCVTiQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQA
 ..  . | |. |. | |.||| . .. |    . . . |||.| |||.|||..|| .. |....     |   | ..||||||||||.|. .|  | ||
.kycnlrvtlrktevfadyiirtfvms.qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

KRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
|... |||   |. .|..| .|||| .||||.| 
kkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 934-1166 3.7e-59 194.8 In-house 8-235 (239) alignment 
Range on Protein: 934-1166
Range on HMM: 8-235/239.0
NKPFNRFKDITVYDDNRIILATNPNldMCQREYINANYVDGYSS-SKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMeh
||  ||. .|  || .|..|    |    . .||||.|.  |    | .||.|| .. .  ||||..|||. . |||.| | || |.||  |||..    
nkaknryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

eEFGPFTVLLQSTQTFPDFIIRQLCVTiQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQA
 ..  . | |. |. | |.||| . .. |    . . . |||.| |||.|||..|| .. |....     |   | ..||||||||||.|. .|  | ||
.kycnlrvtlrktevfadyiirtfvms.qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

KRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
|... |||   |. .|..| .|||| .||||.| 
kkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_PTPN23_pd Subfamily PTPN23 911-1166 4.2e-55 181.6 In-house 17-274 (288) alignment 
Range on Protein: 911-1166
Range on HMM: 17-274/288.0
FESQYTSLKSEEEK---PCIVGYSEENKPFNRFKDITVYDDNRIILAtnpnldMCQREYINANYVDGYSS-SKKFIASQGPMKKTLVDFWRLIWQEKPVS
.. ..  |.....|      .  .. .   ||..||  || ||. |         . .|||| .| . |. . .|||.|.|...|| |||......|   
ldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVfNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMA----TWS
|||... .|  |.|.. |||.   | ..||...| |.|... . .. |.| ....|. .  ....  .|||||..|||.    |. . ..| .    .  
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda.davksvshlqltsWpelGvPasPetllqfldevesayeavqr

PSKGPILVHCSAGVGRTGTFIALDIAL-EQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
.|| |..|||||||||||.|  .  |. |  |.. ..||  .|.|||.||  |||. .|. |. .
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsye
0051429 (Phosphotyrosine protein) phosphatases II 965-1167 5.3e-55 182.2 In-house 5-220 (272) alignment 
Range on Protein: 965-1167
Range on HMM: 5-220/272.0
EYINANYVDGYSS---SKKFIASQGPMKKTLVDFWRLiWQEKPVSIVMVTNLKEGTKNKCELYWP----------NTLMEHEEFGPFTVLLQSTQTFPDF
 ||||..|.|| .    .....|.||.. |  ||||| ....  .||..... |  ..||..|||          ..  .  ..| ..| |.|.....|.
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

IIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHAtpLMSLHKQVMAtwspsKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVD--------IAGI
|.| |..|..   .........| |.|||||||..|  | .| ... .     .||.|||||||..||||..||.. |..  .| .||        ....
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VNRLRQQRMKMVQTLDQYVFLHDA
|..||.||...||| .||.||..|
veelraqrpgavqteeqylflyea
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 905-1166 2.5e-54 179.2 In-house 16-230 (392) alignment 
Range on Protein: 905-1166
Range on HMM: 16-230/392.0
SCHSNGFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPnlDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKP
  ||  | ...  | . .  |  |.  | |.. ||.|.|  || .|..|      |. ...|.|| |.... . | .||||||   .| ||||...||..
nrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid..dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenv

VSIVMVTNLKEGTknkcelywpntlmeheefgpftvllqstqtfpdfiirqlcvtiqdVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPS
 .|.|||.||||                                                .| .| .|.|.| |||..|| |.. |. . |.| | .   
ttiamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy

KGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
  |...||||||||||  |..|  . .||. |.||.  .|  .|..|  |||| .|| |.. 
thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiyg
subfamily_PTPN14_pd Subfamily PTPN14 919-1165 1.8e-53 176.5 In-house 34-289 (300) alignment 
Range on Protein: 919-1165
Range on HMM: 34-289/300.0
KSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLdmcQREYINANYVDGYSSS--KKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEG
| .|.  . ..  .||.. |||||.  |.|||. |... .    . .||||  .    ..  ...|..|||...|. |||...|...   |||.|. .|.
kkredallstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeed

TKNKCELYWPNT--LMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTiqDVF-NDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVM-------ATW--SPS
 |.|.  |.|..    .. ||| | |  . ... . .| ..| .    .  ..  |.     | |||||||.  .. .|  ..|         .     |
gkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklk..hlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskes

KGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
| |.||||||||||||  |  |. ..  . ....||  ...|||.||| .|||| || |..
kPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvY
subfamily_CG7180_pd Subfamily CG7180 923-1166 1.4e-50 166.6 In-house 31-284 (296) alignment 
Range on Protein: 923-1166
Range on HMM: 31-284/296.0
EKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDMCQreYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKnKCE
   |  |. .||.  ||  ..  || ||..| .    .  .  |||| |||..   |..|  ..|.|.|. .||||...|.  ..|..|.  . .| .. 
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myp

LYWPNTLmeHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQ---------DVFNDSHTLTQYHLTSWPD-HGVPDHATPLMSLHKQVMA---TW--SPSKGP
 ||||.   .|..|.. | . ........ ||.. .| .         .|  .  ......|| |.  . ||  .. |. | ..|          | .||
sywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegP

ILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
..|..| |..|.| ..|.|..||....|  ||. . | .||..| ..|.. ..| .. |
vvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYd
subfamily_PTPN1_pd Subfamily PTPN1 917-1163 1.9e-50 166.2 In-house 14-262 (290) alignment 
Range on Protein: 917-1163
Range on HMM: 14-262/290.0
SLKSEE-EKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNldmcqrEYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKE
 .. |  . |. .   .||.. ||..|.. ||  ||.|  . |      .||||. |.     ...| .|||. .|   ||...|..|  ..||. .. |
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

GTKNKCELYWPNTLM-EHEEFG--PFTVLLQSTQTFPDFIIRQLCVTiQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMA--TWSPSKGPILV
  ..||  |||.    .  ..    ..| | |...   ...|.| .. .   .........| |.||| |||.  . ....  .|    . |. .|| ..
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllele.nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavi

HCSAGVGRTGTFIALDIAL---EQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVF
|||||.||.|||. .|  |   |. .    |||   .  ||..|. ..|| ||  |
hcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrf
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 937-1167 2.4e-50 165.9 In-house 41-272 (287) alignment 
Range on Protein: 937-1167
Range on HMM: 41-272/287.0
FNRFKDITVYDDNRIILATNPNLDMcqrEYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTlMEHEEFG
 ||. |.  .||.|..|.....|     .||||||| .|   ..|||.|||.  |. ||||......  |....|   | ...||  |||.        |
knryadvlPiddtrvllsaegelGs...dyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvG

PFTV-LLQSTQTFPDFIIRQLCVTIQDVfNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQV-----MATWSPSKGPILVHCSAGVGRTGTFIALDIALE
 ..| ||. ..  |.. .| | .   .  .... . |..| ||||....  |  |. .  .|     .|  .   ||..||...|.||.|...|. . ..
GysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
. .    ||.| .| |||..|  .||.  |. .| .|
rledlGrvdvaavvirlreyraalvqavvqlrllyea
subfamily_PTPRN_pd Subfamily PTPRN 911-1164 3.7e-50 165.3 In-house 31-284 (297) alignment 
Range on Protein: 911-1164
Range on HMM: 31-284/297.0
FESQYTSLKSEEEKPCI--VGYSEENKPFNRFKDITVYDDNRIILATNPNLDmcQREYINANYV-DGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSI
.| .. .|.. | .|.   |. .|.|   || |..  ||..|. | .. . .  . .||||  . |    .  .||.|||. .|. |||...|..  | |
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasae..ksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

VMVTNLKEGTKNKCELYWPNTlmEHEEFGPFTVLLQSTQTF-PDFIIRQLCVTIQDvFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKG
|..|.|.|   ..|. |||..   .| .. . | | |   .  |...| . .   .  ... |.||.|  |||..|||  | .|. . ..|  ..     
vnltrleeegvkqckrywpde..Gsevyhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrsc

PILVHCSAGVGRTGTFIALDIALEQAK-RERVVDIAGIVNRLRQQRMKMVQTLDQYVFL
||.||||.|.||||..|..|. |.. .   . .|||  .. ||.|| ..|.| ||. | 
pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefa
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 937-1165 4.2e-48 158.4 In-house 59-276 (290) alignment 
Range on Protein: 937-1165
Range on HMM: 59-276/290.0
FNRFKDITVYDDNRIILAtnpnlDMCQREYINANYVDGYSSskKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFG
 ||.||..  |  |.||      |  . .|. ||||.|  .   || .||..|.| .|.||.. |||   |||. .| |  | ||| |.|..  |   ||
knrykdvvcndktrvilk.....dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

PFTVLLQStQTFPDFIIRQLCVTIQDVFN-DSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIALDIALEQAKRE
 .|||    .. .|  | .  ....|. .  .| |  ... ||||. |.  .  |. . . .        ||. ||||||.||||||.|....|.     
eitvlcse.eddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldG

RVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
. .|....|  ||. |.. ||   ||. | 
keldlldlvralrnsrlnsvqvdiqylalv
0041856 (Phosphotyrosine protein) phosphatases II 934-1166 3.7e-47 155.6 In-house 1-165 (182) alignment 
Range on Protein: 934-1166
Range on HMM: 1-165/182.0
NKPFNRFKDITVYDDNRiilatnpnldmcQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTnlkegtknkCELYWPNTLmehe
|.. ||..||  || .|               |||||...|.  ...||| |||...|. ||.|......  .||..|         .|||||. |    
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell....

efgpftvllqstqtfpdfiirqlcvtiqdvfndSHTLTQYHLTSWPDHGVPDhATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIALDIALEQak
                                  .. .||. ..||||||||    | .. ..| .    ..||.|||||||||||||..|... ...  
.................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl..

reRvVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
  . |..  .|. .|..|..||.|..||.||..
..g.vsleeavklvrsrRpgmvitpnqyfflql
0036282 (Phosphotyrosine protein) phosphatases II 965-1166 3.5e-46 152.4 In-house 3-164 (174) alignment 
Range on Protein: 965-1166
Range on HMM: 3-164/174.0
EYINANYVDGYSSSKKFIASQGPMKktlvdFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNtlmeheefgpftvllqstqtfpdfiirqlcvtiqDVF
 ||||...|..  ....||.|||..     ||.......  ..||....||  . ||  |||                                   .  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lre

NDSHTLTQYHLTSWPDHGVPDHATpLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIALDIALEQAKrERVVDIAGIVNRLRQQRMKMVQTLDQYVF
  ...  ||. . |||||||| .. | .. |.|    |  ..||.|||||||||||||..|... | . . |..||.  .| .||.||..|||| .|| |
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

LHD
|..
lyy
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 935-1166 5.9e-43 141.7 In-house 49-281 (305) alignment 
Range on Protein: 935-1166
Range on HMM: 49-281/305.0
KPFNRFKDITVYDDNRIILatNPNldmCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPN---TLME
.  ||.||.   |.||. |  ..       ||| ||||   . .|.|| .| |..||  ||| . .|.|  .| |. ||.|   .||  |..      .|
agknrykdvgcldnnrvkl..egp...wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

HEEFG-PFTVLLQSTQTF-----PDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVmatwSPSKGPILVHCSAGVGRTGTFIAL
 || |   .| ..|..|.      .  ...  ..|.   ....  |.||   ||| |||   . .. | ..      |||||| ||||||.||||. . |
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvml

DIALEQAKRERVV-DIAGIVNRLRQQRMKMVQTLDQYVFLHD
.  |.|    ... |   |....|.|| . .|| .||.|.|.
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhq
0043147 (Phosphotyrosine protein) phosphatases II 964-1165 2.6e-42 139.8 In-house 5-154 (172) alignment 
Range on Protein: 964-1165
Range on HMM: 5-154/172.0
REYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLkegtknkcelywpntlmeheefgpftvllqstqtfpdfiirqlcvtIQDV
. ||||.|.|.|   ..||| |||.  || ||||......   ||..|.|                                                | 
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydp

FNDSHTLTQYHLTSWPDHGVPdHATPLMSLHKQVMA-TWSPSKGPILVHCSAGVGRTGTFIALDIALeqakreRVVDIAGIVNRLRQQRMKMVQTLDQYV
 . ...  ||. ..||||||| ..  |... ...       ..||.|||||||||||||..|... |      . ...  .|. .|..|...||. .|| 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FLH
||.
fly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 922-1166 4.5e-42 138.9 In-house 21-253 (267) alignment 
Range on Protein: 922-1166
Range on HMM: 21-253/267.0
EEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLdmcqreYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLkegTKNKC
..  .   ..|.|. .||. |   |||.|.|| |. .       |||| ||.||   ..||. |.|.|.|  ||. .| ..|   ||..|.     ... 
tsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdni

ELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDvfNDSHTLTQYHLTSWPDHG-VPDHATPLMSLHKQvmATWSPSKGPILVHCSAGVGRTG
 |.||  . . ...  .||     .   |. |  | . ...  . .| .| |.   |        .  ||. .  .          |..|.||.||||.|
rlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn..esahnvtlyyykkwnintnnkpylkplfgilak..nqlengnrPlvvacsdGvGrsG

TFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
||. .|  ||.||.| |.||   . ..|.||. .|.|...|...|.
tflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihe
0049260 (Phosphotyrosine protein) phosphatases II 971-1166 7.7e-42 137.9 In-house 1-144 (152) alignment 
Range on Protein: 971-1166
Range on HMM: 1-144/152.0
YVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWpntlmeheefgpftvllqstqtfpdfiirqlcvtiqdvfndshtl
..|||  ...||| |||.  || ||||.... .   |||.|.| | .| ||| |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

tQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALeqakreRVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
 ||. . ||||||||..  |. |.. .   .  ..||.|||||||||||||..|... |      . |..  .|...|..|...|.. .|. ||..
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 965-1166 2.2e-41 136.8 In-house 13-167 (176) alignment 
Range on Protein: 965-1166
Range on HMM: 13-167/176.0
EYINANYVDGYssskKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNtlmeHE---Efgpftvllqstqtfpdfiirqlcvtiq
 |||||...|.    ..|| |||. .|| ||........   .|..|...|  . ||  |||      |                               
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi...........................

dvfndshtltQYHLTSWPDHGVPDHaTPLMSLHKQVMAtWSPSKGPILVHCSAGVGRTGTFIALDialeQAKRERVVDIAGIVNRLRQQRM-KMVQTLDQ
          ||. . ||||||||. . |..| ...   .  ..||.|||||||.|||||..|..      ..|. ...  .. ..|.||. ..||| .|
..........qylhlpwpDhgvpdl.elllellefire.alkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

YVFLHD
| ||..
yrflye
0049772 (Phosphotyrosine protein) phosphatases II 921-1165 4.8e-41 136.9 In-house 33-273 (314) alignment 
Range on Protein: 921-1165
Range on HMM: 33-273/314.0
EEEKPCIVGYSEENKPFNRFKDITVYDdNRIILatnPNLDMCQREYINANYVDGYsssKKFIASQGPMKKTLVDF----------WRLI--WQEKPVSIV
  |. . |.. ..|.  ||..||  .| || ||   |.|..    ||||.||||.   .||||.|||.. |.|||          ||..  .. ..  ||
lpeltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------VTNLKEGTKNKCELYWPNTLmeheefgpftvllqstqtfpdF-------IirqlcvtiqdvfndSHTLTQYHLTSWPD
|                      ..| ...   .. ....                                              ...  .|. . .||
msrdevladelsrLdaAlgKtpllildgngneptaadlellk.....................eelydpelf..............erlgikylripvpD

HGVPDHATpLMSLHkQVMATWsPSKGPILVHCSAGVGRTGTFIALDIALEQAKrervVDIAGIVNRLRQQRM-----KMVQTLDQYVFLH
...|. .  . ..  ... .. . .||.||||.||.||||||..... . . .    |... .....|..|.      ....|.||.| .
gsaplled.fdefl.efieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefil
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 932-1165 9.3e-40 131.5 In-house 39-270 (307) alignment 
Range on Protein: 932-1165
Range on HMM: 39-270/307.0
EENKPFNRFKDITVYDDNRIILATnpnlDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLME
. |   ||..|. . | .||.. .    |    .|| |||.      ||||..|||...|  .|| .. |||  |..|. .. | .| ||| |||    .
santdknryqdvkcqdkgrivvkf....dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

HEEFG--PFTVL---LQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVmatwSPSKGPILVHCSAGVGRTGTFIALD
.  ||  | |.    | . .  ||  . ..     |  ..| |....  . |||.|||.     . | . |       . |..|||||||||.|| .|. 
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav....rydtnpvvvhcsaGvGrsGtivais

IALEQA-KRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
.  ..  . .   |.  .|. ||.||   .||  ||..||
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylh
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 931-1165 2.6e-38 126.6 In-house 32-263 (285) alignment 
Range on Protein: 931-1165
Range on HMM: 32-263/285.0
SEENKPFNRFKDITVYDDNRIILatnpnlDMCQREYINANYVDGYS-SSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTL
 | |  .||. |. . .. |..|         .|.|| |...         .|..|||. .|| |||..|.|||   ..|.  | ||  .|| ||.|. |
yeanpdlnryadvrcieetrvvl......knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

MEHEEFGPFTVLLQST--QTFPDFIIRQLCVT-IQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMAtWSPSKGPILVHCSAGVGRTGTFIALD
 |  .|| . . |     ..    |.  | |.  .|  ..   . . ..  |||.  |. | |.. |.| |     | . || |||||||||| ||. .|
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgid

IALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
 |  .   .  ...  ||  .|  |.. ||.  |..||.
yatirimenpniemldivremramrfqavqshmqflfly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 936-1165 2.8e-36 119.7 In-house 57-282 (305) alignment 
Range on Protein: 936-1165
Range on HMM: 57-282/305.0
PFNRFKDITVYDDNRIILAtNPNldMCqrEYINANYVDGY-SSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEE
  ||..|. . | . . |. .|.   .  .|| ||||       |.||..|||. .|. .|| .. |.|   |||. .  |  | ||  ||| .  |. |
tknryqdvpcqdqsavkld.kps..ps..dyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

FGPFTVLLQSTQTFPDFIIRQLCVTIQDV-FNDSHTLTQ--YHLTSWPDHGVPDhaTPLMSLhkQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQ
.    |. . . . |     .. .|. .. .. .....    . | ||| |||     | ||  .....   || ||.||||||.||||| .|..  ||.
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvpp..ckltsl..ellsairgskvpivvhcsagigrtgtivaieyilek

-AKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
 |.  ..  .  .|. ||.||   .|.  ||.|.|
iaenkpcppmpelvkalrdqrafsiqndvqylfih
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 933-1165 1.2e-35 118.0 In-house 42-264 (288) alignment 
Range on Protein: 933-1165
Range on HMM: 42-264/288.0
ENKPFNRFKDITVYDDNRIILAtnpnlDMCQrEYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEH
.|   .|....   |  |. |      | ..  ||.|| |      ...| .| |.. |.  .|... ..    |||...| |  |.| . |.|  | |.
anptrdryenlprcditrvkls.....ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

EEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVmatwSPSKGPILVHCSAGVGRTGTFIALDIALEQA
  .| .    .  ..  | ...   . |. . ...  . . ||  |.|.|||.   . . | . .       . ||.||.|||||||||.|   ||||..
arigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialesl

KRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
. .  . |  ....||..|.| .||  ||...|
rlddflgirsllaklreerfkaiqtemqylyvh
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 905-1165 1.5e-35 117.2 In-house 23-283 (310) alignment 
Range on Protein: 905-1165
Range on HMM: 23-283/310.0
SCHSNGFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNldmCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKP
    .|.  ||  | ....        ...   ||. |. . |. |. |  .        .|| ||||      . || ||||...|..||||.|.||. 
klgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidks...ryedyihanyvktnylrstficsqgplqhtiidfwrmifqera

VSIVMVTNLKEGTKNKCELYWPNtLMEHEEFGPFTVLLQStQTFPDFIIRQLCVTIQ--DVFNDS--HTLTQ-----YHLTSWPDHGVPDHATplMSLHK
 ||... .  |  . ||  |||  |   | .|   |   | ..  .| | .|.||.   .|  |     | .      .   ||| ||||      .. .
esilllckvgeegrpkcvgywps.lgvtetygcirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htvpq

QVMATWspSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
...|     .|| .||||||..|... .||........|   ||.  ..  |...|.. .||  ||....
rllaqv..rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 926-1164 3.3e-35 116.1 In-house 29-261 (281) alignment 
Range on Protein: 926-1164
Range on HMM: 29-261/281.0
CIVGYSEENKPFNRFKDITVYDDNRIILAT-NPNLDmcQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELY
| |     |.  ||. .| . |  |. |    || .    .|| |||.      . .| .||| |.|  ||||.||||.  .|||. .. |  ..||  |
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnkn..stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQdvfNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPskgpILVHCSAGVGRTGTFIA
.|       .|  ..|  . .     ..  .| .. .    ... .|..    |||  ||. .  .. . ... |  .|     ..||||||||.||..|
fprnahcclqfdklsvsyedstvnkslvttrlnlsye...getrlithwlwkewpdwqvpessevmlkilrkirarstp....pvihcsagvgrsgtlma

LDIALEQAKRE-RVVDIAGIVNRLRQ-QRMKMVQTLDQYVFL
..|||.  .    . ||  || .||   |   ||||.||...
veialqsihshftlpdikqivshlrvtgraasvqtlqqymli
0051082 (Phosphotyrosine protein) phosphatases II 965-1165 4.4e-35 115.8 In-house 4-146 (151) alignment 
Range on Protein: 965-1165
Range on HMM: 4-146/151.0
EYINANYVDGYssskkFIASQGPMKktlvDFWRLIWQEKPVSIVMVTNLKEGTknKCELYWPNTLmeheefgpftvllqstqtfpdfiirqlcvtiqdvf
 |||..||.|.     ...|.||.     ||..|.....  .||......|    .|  |.|..                                    
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

ndsHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMAtwsPSKGPILVHCSAGVGRTGTFIALDIALEQakrervVDIAGIVNRLRQQRMKMVQTLDQYVFL
   ..........|||.|.|..   ..........   ...||.|||||||.|||||..||.. |..      |... ... .|..|. .||. .|..|.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

H
.
l
PTPc_DSPc_SM00012 1070-1167 7.8e-35 114.6 In-house 2-102 (105) alignment 
Range on Protein: 1070-1167
Range on HMM: 2-102/105.0
LTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSK--GPILVHCSAGVGRTGTFIALDIALEQAKRE-RVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
...|| |.|||||||........| ..|.   . |.  .|..|||||||||||||.||||.|.| ..| . |||  ||..||.||..||||..||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

A
|
a
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 962-1162 2.2e-34 113.6 In-house 73-271 (301) alignment 
Range on Protein: 962-1162
Range on HMM: 73-271/301.0
CQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQ
 .|  | ||...    ...|||.|||.|.|  ||| .. | .   |||...  | ...||| | | .  |. . | |.. ......  .  | .  . ..
GkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleve

DVFN--DSHTLTQYHLTSWPDHGVPDHATPLMSLhkqvMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLD
|  .  ...|.| |  ..|.|.|||   . |. |    |     |. ||.||||||.||. .||. ..   . . .. ....  ...||..| . |||  
dstgkfatrtvthyqysewtdrgvPkshaelfdl....melvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtns

QYV
|  
qly
0044763 (Phosphotyrosine protein) phosphatases II 949-1166 5.4e-34 112.7 In-house 5-165 (178) alignment 
Range on Protein: 949-1166
Range on HMM: 5-165/178.0
NRIILATNpnLDMCQREYINANYVDGYssskKFIASQGPmkktlVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMeheefgpftvllqstqtf
.| .| .    ...  .||||......     ...|..|     .|...|.....  .||..|. .|. ..||  |||                      
trvllsnl..eglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

pdfiirqlcvtiqdvfndshtlTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIALDIALEQakreRVvDIAGIVNRLR
                       ||. . .|||||||    .. ... . .  ....||.||||||||||.||..|... ...    .. ..  .....|
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvr

QQRMkMVQTLDQYVFLHD
..|. .|.. .|. .|..
erRp.ivpnpgqlrqLye
subfamily_ptpA1_pd Subfamily ptpA1 930-1129 2.4e-33 110.5 In-house 43-253 (418) alignment 
Range on Protein: 930-1129
Range on HMM: 43-253/418.0
YSEENKPFNRFKDITVYDDNRIILATNpnLDMCQREYINANYVDGySSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTL
  . |   ||. .|   .  |. |      |    .||||||.|| .  |.||..|||. .|. ||||..|...   |||..   |  . ||. |||. .
dkkhntsknrytnilpvnhtrvqlkki..qdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

M---------EHEEFGPFTVLLQSTQTFPD--FIIRQLCVTIQDvfnDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVM------ATWSPSKGPILVHC
            | || ..| |      |.   | |.. .|..    ... .|||.   |||| .|||. |.  | . .          |  . ||.|||
ggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeg...etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc

SAGVGRTGTFIALDIAL
|||||||||| .  | .
sagvgrtgtfctavimm
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 931-1097 3.1e-30 100.0 In-house 28-193 (297) alignment 
Range on Protein: 931-1097
Range on HMM: 28-193/297.0
SEENKP--FNRFKDITVYDDNRIILATNPnldmCQREYINANYVDGY--SSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWP
.  |     ||..||  .||.|. |   .     .|.||||.||      .  |.| .|||...|. |||.|....    ||||..|.|. ..||  |||
akrnsslrknryrdilatddtrvkllrvi....terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

NTLMEHEEFGPFTVLL--QSTQTFPDFIIRQLCVTIQdvfNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQV
..  |  . | . |    . .. |   |. .| .  .   ..|  ..     ||||||||     |  .. ||
svvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 978-1165 5.5e-29 95.7 In-house 4-197 (199) alignment 
Range on Protein: 978-1165
Range on HMM: 4-197/199.0
SKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDS-HTLTQYHLT
 ...||.| |...|. |||...|.     |||| . .   .    .||| |     ..| ..|  ..  | ||. |  | .| .     |   ...| .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDHAT--PLMSLHKQVMATWSPSK-GPILVHCSAGVGRTGTFIALDIALEQA--KRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
|| ..  |. |    ..   ..|   .   |  |..|||| | | || |.|||| .      .  |||.  . .|||| |  .. .|..| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 978-1165 6.7e-29 95.5 In-house 3-196 (198) alignment 
Range on Protein: 978-1165
Range on HMM: 3-196/198.0
SKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVFNDS-HTLTQYHLT
 ...||.| |...|| |||...|.     |||| . .   .    .||| |     ..| ..|  ..  | ||. |  | .| .     |   ...| .|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDHAT--PLMSLHKQVMATWSPSK-GPILVHCSAGVGRTGTFIALDIALEQA--KRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
|| ..  |. |    ..   ..|   .   |  |..|||| | | || |.|||| .      .  |||.  . .|||| |  .. .|..| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 935-1163 1.3e-28 94.6 In-house 44-267 (312) alignment 
Range on Protein: 935-1163
Range on HMM: 44-267/312.0
KPFNRFKDITVYDDNRIILATNPNLdmcqreYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNT-----L
| .||. .| ..|  |. || . |.      || ||.|   .  ..|...|||...| . ||.|      .||.... . | . .||  |  .      |
kdlnrypniqcwdrgrftlagdenf......yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdl

MEHEEFGPFTVLLQSTQTFPDFII-RQLCVTIQDVFNDShTLTQYHLTSWPDHGVPDHATPLMSLhkqvMATWSPSKGPILVHCSAGVGRTGTFIALDIA
 .|  .  .   ..      | |  | | | ..   ..|  | .|  .||||||.||     . |    ...    | |.. |||||||||||.. ..  
edhrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrl....lsavkkdkkpviahcsagvgrtgtlaliesm

LEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVF
.   .  |  ..  .   ||..| . |... |||.
iaalrhprkqnvkdsfvllrkdrarsvrvfpqyvy
subfamily_egg_pd Subfamily egg 920-1165 7.8e-28 92.0 In-house 26-263 (307) alignment 
Range on Protein: 920-1165
Range on HMM: 26-263/307.0
SEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILatNPNLDMCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGtkN
| .|..    .|..|.   | | .   |  |. |  . .  .   ..| ||.|.|     .|| .| |.| |  ||||...||.   |||.|  ||   .
svdeislttaasdnnlekarskrvhckdssrvkl..elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..e

KCELYWPNTLMEHEEF--GPFTVLLQSTQTFPD--FIIRQLCVtiqdVFNDshtLTQYHLTSW--PDHGVPDHATPLMSLHKQVMAtwspsKGPILVHCS
.|| |||..  .   .  | . .     .  .|  | . .| .    |  |     . .|  |    . . |  .||  | |   .       |..|.. 
rceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl....vGgd...deerflehwqgdvnnssdvysplrvlrklrnl.....skpvvvqdi

AGVGRTGTFIALDIALEQAKRERVV--DIAGIVNRLRQQRMKMVQTLDQYVFLH
 || ...|..|..||| .  |  ..   .   |  ||..|   |..  .|.|..
lGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 914-1165 9.5e-27 88.2 In-house 34-278 (302) alignment 
Range on Protein: 914-1165
Range on HMM: 34-278/302.0
QYTSLKSEEEKpCIVgySEENKPFNRFKDITVYDDNRIILAtnpnldMCQREYINANYVDGYSSSKKFIASQGPMKKTL---VDFWRLIWQEKPVSIVMV
.  ..| . || | .    .|  .|. .|. ..|.|...|.      ... .|.||  |.  . ... | .| | ...     .|||...||| ||.|..
kidtmkvdlek.Cka..fkknlkknqsedvpildsnlvkle......aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvil

TNLKEGTKnKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIiRQLCVTI-QDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSKGPIL
   .| .|   . ..|..  ...|.| . |  .  .   .    .... .  . . .|   . |.|| |... ||.. . |.   ..| |  .... ...
vgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentv

VHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
.    |.|| |.|..| .|.|. ...  . |. ||. .|.|| ..|..|.|||.|.
ivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvsly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 962-1164 1.3e-26 88.4 In-house 44-251 (290) alignment 
Range on Protein: 962-1164
Range on HMM: 44-251/290.0
CQREYINANYVDgYSSSKKFIASQGPMKKT-------LVDFWRLIWQEKPVSIVMVTNLKEGTKN----KCELYWPNTLMEHEEFGPFTVLLQSTQTFPD
 . .|| ||.|  ...  ..|..| | .|.       . .|| .. |||  ..||. . .| ..|     |. | |..  |.  |. .||  .|  .  |
fnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

FIIRQLCVTIQDvfNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIALDIALEQAK-RERVVDIAGIVNRLRQ
...|.|.|. .|  .  .|.| . | .| .  |...   |.|| ..|.|    || |..|||  |. |  .. |....       .  | .. ... ||.
vetRelvvkfdd..eeeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

QRMKMVQTLDQYVFL
|| .....  .. | 
qralaitsalelafv
0048076 (Phosphotyrosine protein) phosphatases II 1024-1166 3e-26 87.2 In-house 2-137 (145) alignment 
Range on Protein: 1024-1166
Range on HMM: 2-137/145.0
YWPNTLMEHEEFGPFTVLLQsTQTFPDFIIRQLCVTIQDVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSPSkGPILVHCSAGVGRTGTFI
|||.   ..  .|.... |.  ... |. |. .     .  . ... .||. ..|||||||| .  |... ... .  .   ||.|||||||||||||..
ywpseilpglylgslptald.lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv

ALDIALEqakrERvVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
|... |.    .. |..  .....|.||...|.. .|. ||..
aaylmll....lg.vsleealelvrsqrpgavpnpgqlrflye
0048179 (Phosphotyrosine protein) phosphatases II 1062-1166 1.3e-25 85.2 In-house 41-139 (144) alignment 
Range on Protein: 1062-1166
Range on HMM: 41-139/144.0
DVFNDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATWSpSKGPILVHCSAGVGRTGTFIALDIALeqakRERvVDIAGIVNRLRQQRMKMVQTLDQY
.     .. .||. ..||||||||... | .. . . .  . ..||.|||||||||||||..|... .    ... ...  .....|..|. .|.. .|.
epefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgql

VFLHD
 ||..
rfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1066-1167 6.1e-25 82.4 In-house 87-189 (440) alignment 
Range on Protein: 1066-1167
Range on HMM: 87-189/440.0
DSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMATW-SPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFL
.|.|| |||  .|||.|||  | |.. . ..|  .    ..||.|||||||.||||  ||.|  | .|||   .||  ..| .|..| .|||| .||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDA
|.|
hea
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 972-1164 4.7e-24 79.4 In-house 83-280 (302) alignment 
Range on Protein: 972-1164
Range on HMM: 83-280/302.0
VDGYSSSKKFI-ASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQT-FPDFIIRQ------LCVTIQDV
.||    .|       | |.||  .| || | .   .| .....|. ..||  |. . . .. .|| .||   | .| . .|  ..      . .. . .
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

F-NDSHTLTQYHLTSWPDHGVPDHATPLMSLHKQVMAtWspsKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYV
  .  .|.   . ..||||| |..| . . . |   . .   |  .|||||||||||||..|.   ..  ....| |.. ||  .|| |   ||. .| .
kkkvkktvdilafsawpdhGapkeaytaldilkfces.y...kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

FL
.|
yl
subfamily_CG42327_pd Subfamily CG42327 950-1100 6.4e-23 75.9 In-house 44-193 (319) alignment 
Range on Protein: 950-1100
Range on HMM: 44-193/319.0
RIILATNPNLDmcQREYINANYVDGYSSSK-KFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPN--TLMEHEEFGPFTVLLQSTQ
|..|   .. |  . ||..|.|| || ...  .||.| .....  ||||..|. .   || .|.| |   ..|  |.|   || ... .| . | |.  .
rvvlqrigddd..kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgre

TFPDFIIRQLCVTIQDVfNDSHTLTQYHLtSWPDHGVPDHATPLMSLHKQVMAT
.   ..|  | .   |  . |  || |    |.. .|| . ..|...  .| ..
vkdryaistlllkrvdk.eesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 927-1031 3.5e-19 63.7 In-house 40-156 (350) alignment 
Range on Protein: 927-1031
Range on HMM: 40-156/350.0
IVGYSEENKPFNRFKDITVYDDNRIILATNP------NLDMCQREYINANYVDGY------SSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLK
|.    |    ||.|.|  |. .|..|  ..      .  .   .||||||.          .. |.|| |.|...|. ||...| . |   |...|.. 
ilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdv

EGTKNKCELYWPNTLME
|   .||. ||..  ..
elnlekcyrYWqegsyd
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 985-1130 7.3e-18 59.5 In-house 39-173 (255) alignment 
Range on Protein: 985-1130
Range on HMM: 39-173/255.0
QgpmkkTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLlqSTQTFPDFIIRQLCVTIQDV-FNDSHTLTQYHLTSWPDHGV
      |.  |.. | | |.  .||.....| ...||. |.|  . |.  .   .|   .|..  | ..| | .| .       ||.. |. . |...  
l.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvt..ttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PDHATPLMSLHKQVMAtwspSkGPILVHCSAGVGRTGTFIALDIALE
|. |  .. . | |      |  ...||||.|.||. .|.  ...  
Pelareilnilkvvrd....s.ksvvvhCstGiGrsaafvlaelvyq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1098-1167 2.3e-17 57.8 In-house 221-290 (297) alignment 
Range on Protein: 1098-1167
Range on HMM: 221-290/297.0
MATWSPSKGPILVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
. .  | . ..||||||||||.|  .  |. |.. ...|. |.| |.. ||.|| ..||||.|. .|.||
lraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_CG42327_pd Subfamily CG42327 1104-1165 2.5e-17 57.5 In-house 246-308 (319) alignment 
Range on Protein: 1104-1165
Range on HMM: 246-308/319.0
SKGPILVHCSAGVGRTGTFIALDIALEQAKRE-RVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
|.||. |||| ||||||. || |||... .   | |||  .|  .|..| . |.| .|| |..
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1105-1167 2.7e-17 57.5 In-house 262-339 (350) alignment 
Range on Protein: 1105-1167
Range on HMM: 262-339/350.0
KGPILVHCSAGVGRTGTFIALDIALE-------QAKRERV-------VD-IAGIVNRLRQQRMKMVQTLDQYVFLHDA
  |||||||||||||||...||  |.         |. |         | |  |||.||.||..|||.|||..|...|
sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYea
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1109-1167 7.5e-15 49.1 In-house 2-60 (69) alignment 
Range on Protein: 1109-1167
Range on HMM: 2-60/69.0
LVHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.||||.| ||||||||. . . . | |..|||   |. .|. |  ||    .|.|.|||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1110-1167 1.5e-14 48.1 In-house 2-59 (69) alignment 
Range on Protein: 1110-1167
Range on HMM: 2-59/69.0
VHCSAGVGRTGTFIALDIALEQAKRERVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
||||.| ||||||||. . . . | |..|||   |. .|. |  ||   ..|.|.|||
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda
subfamily_hpo-7_pd Subfamily hpo-7 988-1130 8.6e-14 46.1 In-house 43-179 (263) alignment 
Range on Protein: 988-1130
Range on HMM: 43-179/263.0
MKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTfpDFIIRQLCVT--IQDvFNDSHTLTQYHLTSWPDHGVPD
. .|.  |.. | | |.  .||... .|  ..||. |.|  . |   .   .|    .|   | ... | ..  ...     ||...|  . |...  | 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlge.KkkthtvkhysykgWiekndpe

HATPLMSLHKQVMAtwspSKgPILVHCSAGVGRTGTFIALDIALE
 |   . . | .      || .. ||||.|.||.  |   ...  
lareilnilkvarn....sk.slvvhcstGiGrsaafsvaElvyq
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 935-1164 2.5e-13 44.3 In-house 48-271 (303) alignment 
Range on Protein: 935-1164
Range on HMM: 48-271/303.0
KPFNRFKDITVYDDNRIILAtnpnldmcQREYINANYVDgYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNT--LMEH
   ||| |. . |  .. |.        .  || |.|..   |||| | .| |. .|  |||..| ..|   ....    |  |   .  .|.   ... 
mdknrfvdvicldhskvkls........dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

EEFGPFTVLLQSTQTFPDFIIRQLCVTIQDVfndSHTLTQYHLTSWPDHGVPDHATPLMSL----HKQVMATWSPSKGPILVHCSaGVGRTGTFIALDIA
||       ..  .    . .. | |.  |       |  .|  .||   .| ...| .       . |.  .|.|. .. .  | |.||.|||  .. |
eersirvgefkrvelgdgwvlkvlsvsngdy...ksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls.gcgragtfalfeta

LEQAKRE-RVVDIAGIVNRLRQQRMKMVQTLDQYVFL
    . |   .|.   .. .|. |.. || | |. ..
hlslhseqasldlvkclenvrngrlhavqnlsqfsvv
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 893-986 7.1e-13 42.6 In-house 4-95 (95) alignment 
Range on Protein: 893-986
Range on HMM: 4-95/95.0
PISLEDLNIHVTSCHSN---GFESQYTSLKSEEEKPCIVGYSEENKPFNRFKDITVYDDNRIILATNPNLDmcqreYINANYVDGYSSSKKFIASQG
|| .  .  ||   |||    |. .. |.      |  || || | | ||| .|  ||  |..|.|. . |     |||| .||||.  . .||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsd.....yinacfvdgyarkncyiaaqg
fn3 Fibronectin type III domain 572-661 3e-12 39.7 Pfam-A 1-85 (85) alignment 
Range on Protein: 572-661
Range on HMM: 1-85/85.0
SPVTSLSVSNVSTTGITLNWTIP-SSDNYVTYYTISYTPSCPQLssvnemV----SVAPHqsitTYSYTLIGLYSGMNYTITVRAGNVLGGSDPS
|... ||||.|..| .||.|. | . .  .|.|.. | ..  .       .    .| ..    |.|.|| ||  |..|...|.| |  |.. .|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge......ewkeftvprt....ttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 937-1028 3.2e-12 40.4 In-house 51-156 (349) alignment 
Range on Protein: 937-1028
Range on HMM: 51-156/349.0
FNRFKDITVYDDNRIILATNPN-----------LDMCQ-REYINANYVD--GYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCE
 ||.|||  |.  |..|   ..            | ..  .||||||.    .|  ||.|| | |.  |. ||...|  ..   .. ... || . .||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

LYWPNT
 || . 
iywqel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 973-1047 4e-12 40.2 In-house 230-300 (440) alignment 
Range on Protein: 973-1047
Range on HMM: 230-300/440.0
DGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTknkCELYWPNTLmEHEEFGPFTVLLQSTQT
.|||  . |||.| |.  |..|||||. . .  .|.|. .|.. |   | .|||        ||||||  . .. 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvnt.rsvtfgpftvghkgsen
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1106-1167 6.5e-12 39.4 In-house 266-339 (349) alignment 
Range on Protein: 1106-1167
Range on HMM: 266-339/349.0
GPILVHCSAGVGRTGTFIALDIALE--QAKRER---------VV-DIAGIVNRLRQQRMKMVQTLDQYVFLHDA
 ..||||||| ||||... ||. |.  .  ..              |  ||| ||.||. ||| | |......|
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyea
fn3 Fibronectin type III domain 300-374 3.3e-11 36.3 Pfam-A 2-79 (85) alignment 
Range on Protein: 300-374
Range on HMM: 2-79/85.0
APTFLTEIRKTATTITVSWTAF--NSSDADGYVVNVTSDTDT--VQAVQVEGSSNnTITLNGLRGETTYSITVRAYQQL
||. |. .  |.|..|.||..   .... .|| | . .....   . ..|..... . ||.||.  |.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 738-827 9.7e-10 31.7 Pfam-A 10-84 (85) alignment 
Range on Protein: 738-827
Range on HMM: 10-84/85.0
SMmDTTWAVISWSVPSyiPSDYPIITYEIGYHMLQSGNcsmvdddginiqVFNQYSNFSNSTLTTITGLYSETCYIFSVRAYTDNGYGSW
..  .| ...||| |.  . . ||  ||. | . ..|.            . ..... ...|  |.|||   | | |.|.|....|.| .
ev.tstsltlsWsppk..dgggpitgYeveyrekggge............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 939-1083 1.5e-09 31.9 In-house 101-235 (244) alignment 
Range on Protein: 939-1083
Range on HMM: 101-235/244.0
RFKDITVYDDNRIILATNpnlDMcQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWqEKPVSIVMVTnlkeGTKNKCELYWPNTL-MEHEEfGP
|      .| ||. |.      |    |||| .|     . ..| .| |.  | .|||...  |. | ...|     |. .. . |||..  .|  |   
regaglpfdfnrvplskg...sm.gntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvl....gsveeedeywpdseplewye.ed

FTVLLQSTQTFPDfiIRQLCVTIQDVFNDSH-TLTQYHLTSWPDHGV
 || |   . | .  |.   . |.  .|.|| .|| . .. ||  | 
itvtltdrdefkn..ikasnleiesdmneshqaltmfqisnwpsdgt
0038934 (Phosphotyrosine protein) phosphatases II 1060-1125 1e-08 30.5 In-house 57-135 (194) alignment 
Range on Protein: 1060-1125
Range on HMM: 57-135/194.0
IQDVFNDSHTLTQYHLTSWPDHGVP-------DH-ATPLMSLHKQVM-----ATWSPSKGPILVHCSAGVGRTGTFIAL
.  | . ..| . |. . ....|.        |. ..| ... .. .      .   ..| ..||| ||.|||||..| 
lglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 934-1021 1.3e-08 28.8 In-house 34-118 (332) alignment 
Range on Protein: 934-1021
Range on HMM: 34-118/332.0
NKPFNRFKDITVYDDNRIILATNPNLDmcqrEYINANYVDGYSSSKKFIASQGPMK-KTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKC
|  .||   . ..| .|. || .   |    .. ||..|||||    .| .| |.. .|   |||.. . ||  |... .. |  | |.
nmdmnriphlycfdhsrvelapqdgkd....dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 932-1011 1.6e-08 28.5 In-house 35-117 (347) alignment 
Range on Protein: 932-1011
Range on HMM: 35-117/347.0
EENKPFNRFKDITVYDDNRIILAtNPNLDMCQ----REYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVT
| .   || ||  . |. |..|.   . ....      |||| ..    .||..| .| |. .|. |||...   |   .| . 
ekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_eak_pd Subfamily eak 961-1094 1.8e-08 28.2 In-house 75-204 (332) alignment 
Range on Protein: 961-1094
Range on HMM: 75-204/332.0
MCQREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWQEKPVSIVMVTNLKEGTKNKCELYWPNTLMEHEEFGPFTVLLQSTQTFPDFIIRQLCVTi
. .  ||||  ..     .|.| .  . .. .  ||... ..|  .||.. .  |   .| . |.|.   |  .|| . |  ..      .  |.| .. 
lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllels.

qdVFNDSHTLTQYHLTSWPDHGVPDHAtPLMSLH
  . |..| .  |..  | .  .|     ...|.
..kGnethrvlhykvfGwtettlpkye.dflalr
subfamily_PTPDC1_pd Subfamily PTPDC1 1072-1165 2.7e-08 28.4 In-house 84-169 (182) alignment 
Range on Protein: 1072-1165
Range on HMM: 84-169/182.0
QYHLTSWPDHGVPDHATpLMSLHKqVMaTWSPSKGPILVHCSAGVGRTGTFIALDIALEQAkrervVDIAGIVNRLRQQRMKMVQTLDQYVFLH
 ..  .|.|.||.   . .. . | |. . . ..| . ||| || ||||  ||  .   .      .. .  .. .|..| | .|| .|  ...
yvynfgwkDygvasler.iLdivk.vv.afalqegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvk
PTEN_1 1071-1124 4.9e-08 28.0 In-house 95-149 (196) alignment 
Range on Protein: 1071-1124
Range on HMM: 95-149/196.0
TQYHLTSWPDHGVPDHAtPLMSLHKQVMATWS--PSKGPILVHCSAGVGRTGTFIA
 .|.  ...|||.|. .  |.   |...  ..  |... .|||| ||.||.|| .|
veylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
fn3 Fibronectin type III domain 665-719 9e-08 25.3 Pfam-A 26-85 (85) alignment 
Range on Protein: 665-719
Range on HMM: 26-85/85.0
KDTMPTGYTVMIS----NS-SITYNLTSTERYIILNDLVFGTEYNISVAAVNSVGRGPFS
 .   |||.|  .    .. . ......|..  .|..|  ||||...|.||| .| ||.|
gggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 963-1083 1.4e-07 25.8 In-house 12-126 (130) alignment 
Range on Protein: 963-1083
Range on HMM: 12-126/130.0
QREYINANYVDGYSSSKKFIASQGPMKKTLVDFWRLIWqEKPVSIVMVTnlkeGTKNKCELYWPNTlmEHEEFGPFTVLLQSTQTFPDFIIRQLCVTIQD
. .||||..|     ..... .| |. .| .|||...  |. | ...|     |. .. . |||..  |  |.    ... .|.      |.   . |..
gntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvl....gsveeedeywpds..ePlewyeediivtltdrdefknikasnleies

VFNDSH-TLTQYHLTSWPDHGV
 .|.|| .|| .... ||  | 
dlneshqaltmfqisnwpsdgt
fn3 Fibronectin type III domain 486-553 2.3e-07 24.0 Pfam-A 1-76 (85) alignment 
Range on Protein: 486-553
Range on HMM: 1-76/85.0
SPPNNVRGFILNATSIKVNWTTT----SETNGYVIEYATGGAT-----RNVVSTrEYEIVLTDLSPMSTYIISVYSY
|.| |..    ..||. ..|.      ..  || .||.. | .     ..| .| ... .||.| | ..| ..|...
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprt.ttsvtltgLkpgteYefrVqav
subfamily_CDC14_pd Subfamily CDC14 1085-1125 1.5e-06 22.3 In-house 243-283 (328) alignment 
Range on Protein: 1085-1125
Range on HMM: 243-283/328.0
DHATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAL
| .||  .. |. ..    ..| | ||| ||.|||||.|| 
DGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac
PTPc_motif_SM00404 1089-1124 6.3e-06 21.1 In-house 64-99 (140) alignment 
Range on Protein: 1089-1124
Range on HMM: 64-99/140.0
PLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIA
. ..  .... .   ..| .|||| ||| |..|.|.
kyldkvldfienaekkggkvlVHCqaGvSRSatlii
0048567 (Phosphotyrosine protein) phosphatases II 1048-1125 6.6e-06 20.6 In-house 11-97 (157) alignment 
Range on Protein: 1048-1125
Range on HMM: 11-97/157.0
FPDFIIRQLCVTIQDVFNDSHTL----TQYHLTSWPDHGvPDHATPLMSLHKQVMATW---SPSKGPILVHCSAGV---GRTGTFIAL
 || ..  | .  .. . . . .    . .... . |.| | . . |... ....  .   .  ...| |||.||    |||.|.|..
ipdrlyfallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc