Gene PTPRD-67 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP125_AA protein Get Run
AqueP125_AA_1373-1652 phosphatase_domain Get Run
AqueP125_AA_1664-1910 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1378-1646 1.3e-115 380.3 In-house 4-289 (301) alignment 
Range on Protein: 1378-1646
Range on HMM: 4-289/301.0
NDLVNHIAKYSNKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWR
.. ....||.|||||.|| .|..|.|..||||...|||.||||..|||||||||||.|.|||..|.|||||||||||||...||||.|||| .||.||||
dlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWr

LIWQERPMHIVMLTDPKECIKNKwCEQYWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSN--------------DSHTLTQYHLTSWPDHG
|||||.|..|||.|. ||..|.| ||||||.. .|.|.|||| |||.| ...|.|.||.|||.| ||||              .|....|...|.||..|
liwqekpvsivmvtnlkegtksk.ceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdG

V----PKPLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
|       | ............. ||..||||..|.|.|......|.|||. .|||||. ......|......|.||.||....|..
vvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1374-1671 1e-108 358.1 In-house 3-303 (305) alignment 
Range on Protein: 1374-1671
Range on HMM: 3-303/305.0
PISINDLVNHI----AKYSNKFEDQYLRLYTGnDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYmcEREYINASYIDGYSSSNKFIATQGPMV
.|...|| ..|    .. ....| ||  ||.  . .. || ...||  ||...||..||.|||||....|   ...||||||.|||....|.|..|||. 
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

NTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPK---
||.|||||||..|.. .|||||. .|  |.| |.|||| .  |...||.|.|.|.. .. . ...| |.. | |....|.|..||.||.|||||||.   
ntvadfWrliveekvstivmltklveggkdk.CrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

PLLSLHKQVMATWSPSEG-PILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPADKFAT
 |||| |.|. ... ..| |.||||||||||||.|||.|||||.. .|.|||.......||..|||||||||||||||||.  | |. |.|.|  . .  
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdald.elitcgdtsiigsnlra

KLQELK
... ||
rvnklk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1666-1914 5.6e-105 345.3 In-house 20-298 (301) alignment 
Range on Protein: 1666-1914
Range on HMM: 20-298/301.0
KLQEL---KEIDSSTGCSGLQSQFELLSQVTPDLDDATEDNAGEDLAKnqGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC
. .||   ..  .. |.|  .....   ..|.  |.    .  ..| .   ...|.| |.  || .||.||.||.||..| .|||..|...|...|||..
qykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldl..cqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt

GEEDC----CYPYWTGLSTHDDFVVE----IANEI-----------------KSNGYIERMLNVESR----NVLQLQVTDWPQDGVVREPRTVLQVIDDV
.....    |. ||   ..... ...    . ||                   .||||||...|.|.    .||||||||||||||||||||||||||||
nlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddv

IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQMNKA
||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||.|..
ihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_PTPRD_pd Subfamily PTPRD 1373-1711 1.3e-103 342.6 In-house 3-342 (564) alignment 
Range on Protein: 1373-1711
Range on HMM: 3-342/564.0
LPISINDLVNHIAKYS----NKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLymCEREYINASYIDGYSSSNKFIATQGPM
 ||....| .|.||       ||| .| .. .|.  ....   ..||  ||...|. || .|..|.. ..    . .|||||.|||| .....||||||.
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPl

VNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRAlMeEEKFGPFIVTLTNVANHPSFTIRSLNViIPDGSNDSHTLTQYHLTSWPDHGVPK--
 .|..||||..|...   |||||  .|  |.| |..|||     .|..| ..|||..  .   ..||....     |..|.. .|.| |||||||||.  
aetiedFWRmvweqnsstiVmltkleEkgkvk.chkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesa

-PLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVfSETIIGGETEIPADKFAT
 .||.| ..| |...| .|||.||||||||||||||.||. ||..  |..||| ..|..||.||  |||| .||.|.|.|.  | .  |.||...... .
tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheai.lealacgntevesenlkq

KLQELKEIDSSTGCSGLQSQFELLSqvT---PDLDDATEDNAGEDLAKN
.||.|.|... |. .||.  |. |.  |    .|.. .  .  ... ||
hlqkLaeveedtemtgleleFqrLa..takeieleefavatkpknkkkn
0051299 (Phosphotyrosine protein) phosphatases II 1374-1647 1.9e-85 282.1 In-house 4-283 (288) alignment 
Range on Protein: 1374-1647
Range on HMM: 4-283/288.0
PISINDLVNHIAKY----SNKFEDQYLRLYTGN-DRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGPM
.||...|.... |.     ....... .|.  . |.......  ||.  ||.. |  ||..|..|.. ..  . .  |||||||||| ...||||||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPl

VNTLADFWRLIWQERPMHIVMLTDPKEcIKNKWCEQYWPRalMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPD---GSNDSHTLTQYHLTSWPDHGVP
 ||..||||..|...  .|||||.. |  ... |.||||    . ...|.. |||...  ....|.| | |   |   |.. |.| |..| |.|||||||
pntvedFWrmvweqnvrvIvmltklve.lgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

K---PLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
    .||.. ..|.   ....||..|||||||||||||||.|..||| ..||.||. ..|.|||.||. ||||..||.|...|..
dspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall
0040438 (Phosphotyrosine protein) phosphatases II 1386-1687 7.6e-85 280.3 In-house 15-312 (317) alignment 
Range on Protein: 1386-1687
Range on HMM: 15-312/317.0
KYSNKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPM
.  ....... .|.. .  ...|..  ||| .||.  |  ||..|..|.| ..    .  ||||||.||.. ..||||||||. ||..||||..|...  
sdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

HIVMLTDPKEcIKNKWCEQYWPRalMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPdGSNDSHTLTQYHLTSWPDHGVP---KPLLSLHKQVMATWSPS
.|||||...|  ... |.||||    |. ..|.|.|||...  ....|.| | |    |...|.|.|..| |.|||||||   ..||.. ..| .  ...
vivmLtelee.lgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedp

EGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFSETiIGGETEIPADKFATKLQELKEIDSSTGCSGL
.||.||||||||||||||||....||| ..|| ||.  .|..||.||...|||..||.||.||..      ..| .|| ....||..|....  .. .. 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl.krkltlepaselklkllklliplalddvklk

QSQFE
.....
ekelk
0050432 (Phosphotyrosine protein) phosphatases II 1374-1647 1.2e-83 276.3 In-house 25-296 (308) alignment 
Range on Protein: 1374-1647
Range on HMM: 25-296/308.0
PISINDLVNHIAK--YSNKFEDQYLRLYTGN-DRPCTVGYTDENKYLNRFQQITVYDDNRIILtpnpnlYmCEREYINASYIDGY--SSSNKFIATQGPM
..|. ||.... |   . ..| .. .|.    .....|..  ||| .||.  |  || .|..|         .  ||||||.|||   ...||||||||.
klsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPl

VNTLADFWRLIWQERPMHIVMLTDPKEcIKNKWCEQYWPRALM-EEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSnDSHTLTQYHLTSWPDHGVP--
 ||..||||..|...  .|||||.. |  . . |.||||  |  . ...|.| |||... .....|.| | .   ... .|.|.|..| |.|||||||  
pntvedFwrmvweqnvrvIvmLtklve.ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPps

-KPLLSLHKQVMATWspSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
 ..||.. ..|  .   ..|||.|||||||||||||||.|..||| ..|| ||. ..|..||.||. ||||..||.||..|..
peilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall
0046845 (Phosphotyrosine protein) phosphatases II 1391-1647 2.7e-83 274.9 In-house 2-271 (284) alignment 
Range on Protein: 1391-1647
Range on HMM: 2-271/284.0
FEDQYLRLYTGNDR---PCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlYMCEREYINASYIDGY-----SSSNKFIATQGPMVNTLADFWRLIWQE
.|... .|.  .     ...|..  ||. .||...| .||..|..|.. ..  . . .||||||.|||      ...||||||||. ||..||||..|..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RPMHIVMLTDPKEcIKNKWCEQYWPRAlMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVP---KPLLSLHKQVMATW
.  .|||||.. |  ... |.||||    |  ..|.|.|||... .....|.| | .   . .. |.|.|..| |||||||||   ..||.. ..|    
nvrvIVmltelve.ngrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

S--PSEGPILVHCSAGVGRTGTFIAIDIALEQADREG---VVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
.  |..|||.|||||||||||||||.|..||| ..||   .||. ..|.|||.||. |||||.||.|...|..
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyeall
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1381-1647 4.6e-83 273.4 In-house 12-280 (290) alignment 
Range on Protein: 1381-1647
Range on HMM: 12-280/290.0
VNHIAKYSNKFEDQYLRLYTG-NDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLI
.|. ||  ..|..|. .| .| ..   ||| | .|| ||||..| |||||||.| | ..   |. |||||.||.||. ....||||||. |||.|||.||
anghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

WQERPMHIVMLTDPKECIKnKWCEQYWPRAlmEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHG-VPKP---LLSLHKQV
|||.   |||||. .|  | . | |||| .  . ...|.| ..|.|  .. ....| |.|   . .......|||..|.|...| |..|   ||......
wqekvtiivmltniieegk.vkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemy

MATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
   . . ...|.||||..|||...|.|........  |||.|.  .....|.|....||| .|| .... |.
ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1375-1687 4e-82 270.8 In-house 2-316 (318) alignment 
Range on Protein: 1375-1687
Range on HMM: 2-316/318.0
ISINDLVNHIAKYSN----KFEDQYLRLYTGNDRPCTV-GYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGPMV
||..|| .|...  .    ... .| ||   .. . ..   .. ||. ||.. |. ||. |. |..  .    . .||||.||||| .....||.|.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmleg..eegsDyinanyidGyrrkkayiaaqaPlp

NTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRAlmEEEKFGPFIVTLTNVANHPSFTIRSLNVIIpDGSNDSHTLTQYHLTSWPDHGVPK---
.|. ||||..|.   . |||||. .|  |.| ...|||    . ...|   |.|..  .  ....|...|   .....| .  ||| |||||.|||.   
etieDfWrmvWeqnsavivmltqeeergkak.vhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesga

PLLSLHKQVMATW-SPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVfSETIIGGETEIPADKFAT
 ||.| .|| ..  ....|||.|||||||||||.|||.|| ||..  |..||. ..|..||.||  |||| |||.|..|..  | .. |.||. |.....
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvl.lealasgdtevdasdlrs

KLQELKEIDSSTGCSGLQSQFE
...||.| |. .| . .. .|.
rirelreqdpesgttemdaefq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1711-1913 1.1e-81 269.3 In-house 70-287 (305) alignment 
Range on Protein: 1711-1913
Range on HMM: 70-287/305.0
NQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC----GEEDCCYPYWTGLSTH----DDFVVEIANEIKSNGYIERMLNV-
... . | | |.  ||. ||..|.||.|..|| .|||..||..||| ||||.    |..|.|. ||..  |.    ..|.||. .| . ..|||| |.. 
slddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkis

------ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTL
      |||.|||.|.||||..||.... ..|..|..| ..|.|  | |..||||..|.|.||...|.| ||..|.|.|||||.|.|..|......|.||
iededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtl

EQYTSIYDVIDMYLQMNK
.||....|..| ...  .
dqYvflhdaldelitcgd
0036941 (Phosphotyrosine protein) phosphatases II 1402-1647 1.2e-81 269.6 In-house 27-274 (297) alignment 
Range on Protein: 1402-1647
Range on HMM: 27-274/297.0
NDRPCTVGYTDENKYLNRFQQITVYDDNRIILtpnPNlymCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECiKNKW
.. ...|.   ||. .||.  |  ||..|..|   ..    .  ||||||.|||. ..||||||||. ||..||||..|...  .|||||.. |    . 
llgslsvallpenleknRykdilpydhtRVkl...dd...egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel.grek

CEQYWPRALMEEEKFGPFIVTLTNVAN--HPSFTIRSLNVIIPdGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMA--TWSPSEGPILVHCSAGV
|.||||    |. ..|.|.|||..|    ....|.| | |    |...|.|.|..| |.|||||||    .||.. ..|      .||.||.||||||||
caqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

GRTGTFIAIDIALEQAD---REGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
||.|||||.|..|.| .   .|| |||  .|. ||.||. .||||.||.||..|..
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall
0047943 (Phosphotyrosine protein) phosphatases II 1402-1647 2.8e-80 265.0 In-house 26-269 (273) alignment 
Range on Protein: 1402-1647
Range on HMM: 26-269/273.0
NDRPCTVGYTDENKYLNRFQQITVYDDNRIILtpnpnlYMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKEcIKNKW
.. ...|..  ||| .||.. |  ||..|..|       . .  ||||||.||| ...||||||||. ||..||||..|...  .|||||.. |  ... 
plltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelve.lgrek

CEQYWPRALME-EEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNdSHTLTQYHLTSWPDHGVP---KPLLSLHKQVMATWSP--SEGPILVHCSAGVG
|.||||    | ....|.|.|||... .....|.| | .   . .. |.| |..| |.|||||||   ..||.. ..|. . .   |.||..||||||||
caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvg

RTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
|||||||.|..|.|  .|| ||.  .|..||.||. ||||..||.||..|..
RtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
DSPc_SM00195 1391-1647 3.3e-80 264.6 In-house 2-259 (263) alignment 
Range on Protein: 1391-1647
Range on HMM: 2-259/263.0
FEDQYLRLYTGN-DRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLymCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVM
.. .. .| . . ....| .  ..||  ||...| .||..|..|.....    . .||||.||.|.....|.||||||. .|..||||..|.|.   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LTDPKECIKNKwCEQYWPRALMEEEKFGPFIVTLTNVANHP-SFTIRSLNVIIPDGsNDSHTLTQYHLTSWPDHGVP---KPLLSLHKQVMATWSPSEGP
||...|. |.| |..|||.   ..|.|| . |.|..| ... ....| |..   .  ......|||. ..|||||||   |..|.| ..|  . | |.||
lteeeengkek.cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

ILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
|.|||||||||||||..|||.|.. ..|  |||  ||..||.||..|||||.|| |...|. 
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
PTPc_SM00194 1391-1647 3.3e-80 264.6 In-house 2-259 (263) alignment 
Range on Protein: 1391-1647
Range on HMM: 2-259/263.0
FEDQYLRLYTGN-DRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLymCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVM
.. .. .| . . ....| .  ..||  ||...| .||..|..|.....    . .||||.||.|.....|.||||||. .|..||||..|.|.   |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LTDPKECIKNKwCEQYWPRALMEEEKFGPFIVTLTNVANHP-SFTIRSLNVIIPDGsNDSHTLTQYHLTSWPDHGVP---KPLLSLHKQVMATWSPSEGP
||...|. |.| |..|||.   ..|.|| . |.|..| ... ....| |..   .  ......|||. ..|||||||   |..|.| ..|  . | |.||
lteeeengkek.cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

ILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
|.|||||||||||||..|||.|.. ..|  |||  ||..||.||..|||||.|| |...|. 
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeail
0045450 (Phosphotyrosine protein) phosphatases II 1382-1646 5e-80 264.8 In-house 20-300 (307) alignment 
Range on Protein: 1382-1646
Range on HMM: 20-300/307.0
NHIAKYSNKFEDQYLRLYTGND---RPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLyMCEREYINASYI--------DGYSSSNKFIATQGPMVN
  ...  .... .. .|.  ..    ......  ||| .||.. |  ||..|..|.. ..  . .  ||||||.        ||| ...||||||||. .
lllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TLADFWRLIWQERPMHIVMLTDPKECiKNKWCEQYWPRAlMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVP---KP
|..||||..|...  .|||||...|. ... | ||||    ||  .|.| |||...  ....|.| |.|   ||.. |.|.|..| |.|||||||   ..
tvedFwrmlweqgvtvivmltelvel.grekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfee

LLSLHKQVMA--TWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGV---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
||.. ..|..   ..|..||.||||||||||||||||....|.| ..||.   ||.  .|..||.||...||...||.||..|.
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0043336 (Phosphotyrosine protein) phosphatases II 1382-1646 9.9e-80 263.2 In-house 9-273 (278) alignment 
Range on Protein: 1382-1646
Range on HMM: 9-273/278.0
NH----IAKYSNKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWR
..     ...  ... .. .|.. .  ......  ||| .||.  |  || .|..|.. ..       ||||||.|||. ..||||||||. .|..||||
kallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwr

LIWQERPMHIVMLTDPKEcIKNKWCEQYWPralMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIpDGSNDSHTLTQYHLTSWPDHGVP---KPLLSLHKQ
..|...  .|||||...|  ... | ||||    . ...|.| |||...  .. .|.| |.|    |.. |.| |.|| ..|||||||   ..||.. |.
mvwelgvttivmLtelve.lgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflka

VMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
|.   ..|.||.||||||||||||||||....|||...|| ||.  .|..||.||...|||..||.||..|.
vrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1374-1686 1.7e-79 262.2 In-house 4-318 (319) alignment 
Range on Protein: 1374-1686
Range on HMM: 4-318/319.0
PISINDLVNHIAKY----SNKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGPMV
.| ...| ... ..    ....| ..  | ....   .   ..|||  ||.|.|  ||  |..|.. ..  . . .|||||.||||   .||||||.|. 
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqaPle

NTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALMeeEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPK---
||. ||||..|.|. . .||||. .| .| | ...|||.. .  |..| .|||| .  .   . || |.. .  .  .. ...... |.||||.||.   
ntiedfWrmvWeeessivvmltklveklkvk.lkkywpeenf..eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekat

PLLSLHKQVMATWSP-SEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPADKFAT
 || | |..  ...  ..||| ||||||||||||||..|..||.  .|||.|.  .|.||| ||  |||. .|| |...|.  | .  |.|||  ... .
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeall.eaveagdteievqdlrd

KLQELKEIDSSTGCSGLQSQF
.|..|.| .. || .||. .|
rlkqlaekvadtgetgleref
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1384-1648 2.6e-79 261.2 In-house 15-276 (287) alignment 
Range on Protein: 1384-1648
Range on HMM: 15-276/287.0
IAKYSNKFEDQYLRLYT--GNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTpnpnlyMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQ
 || .. |..|.  |     ..   |.. . .|| .||..|| |.|..|..|        .. .||||..||||.....||....||.||. .||.||..
hakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPmfntarnfWklidd

ERPMHIVMLTDPKECiKNKWCEQYWPRALMeeEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHG-VPKP---LLSLHKQVMA
...  ||||.. ||  ... | ||||        .|.. ..|.|   . ....| |.|.  . ..| ....||..|.|...| |..|   || ..... .
rnvtaivmlcqeken.deevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

TWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFS
   .....|.||||..|||...|.|..........|||.|.  .... |.|....||| .|| |. |.|  
qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivle
0039614 (Phosphotyrosine protein) phosphatases II 1386-1647 1.5e-78 259.6 In-house 29-286 (297) alignment 
Range on Protein: 1386-1647
Range on HMM: 29-286/297.0
KYSNKFEDQYLRLYTGNDrPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYMcEREYINASYIDGYSS-SNKFIATQGPMVNTLADFWRLIWQERP
. ..... .. .|.  .. ......  ||| .||.. |  ||..|..|.|... .. .  ||||||.|||.  ..||||||||. .|..||||..|... 
nsktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

MHIVMLTDPKECIKnkWCEQYWPRALMeeeKFGPFIVTLTNVANHPSFTIRSLNVIIpdgSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWS-
 .|||||...|. .   |.||||       ..|.| |||..|  .. .|.| |.|     .. |.|.|... |.|||||||     ||.. ..|.   . 
tvivmLtklvelgr..kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealae

-PSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
 |..||.||||||||||||||||....||| ..|| ||.  .|..||.||...|||..||.||.||..
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
subfamily_PTPRB_pd Subfamily PTPRB 1373-1648 2.7e-77 254.7 In-house 5-283 (293) alignment 
Range on Protein: 1373-1648
Range on HMM: 5-283/293.0
LPISINDLVNHIAKYS----NKFEDQYLRLY-TGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGP
 ||..... .|..| .     .| ..| .|   |.|. ...  . .|.  ||...|  || .|. |..  .    . .||||.||.||.| ..|||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkd..esgsDYinanyipgynsprefiatqGP

MVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALmEEEKFGPFIVTLTNVANHPSFTIRSLNVIIpdgSNDSHTLTQYHLTSWPDHGVP--
. .|. ||||..|...   |||||.  |  | | ||.|||.   |.  .|   |||..  .   ..||.|..     ........||| |||||||||  
lpetvddfWrmvwekkssiivmltqlvekgkvk.CeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPek

-KPLLSLHKQVMATW--SPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFS
 |.||.. ..|  .   . |..||.|||||||||||||||.|  |.. ..| .|||.||| .||..|. .||| .||.|.|..| .
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
Y_phosphatase Protein-tyrosine phosphatase 1414-1647 6.7e-75 246.9 Pfam-A 1-234 (235) alignment 
Range on Protein: 1414-1647
Range on HMM: 1-234/235.0
NKYLNRFQQITVYDDNRIILtpnpN----LYMcereYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECiKNKWCEQYWPRA
||  ||...|..||..|. |    .           ||||.|..||....||||||||. .|..||||..|||.   |||||. .|  ... |.||||..
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek.grekcaqYwpee

LMEEEKFGPFIVTLT-NVA-NHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVP---KPLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAID
  |....| . |.|. ..  .. ..|.| |..   ..........|.|.|.|||||||   |.||.| ..|  . ....||..|||||||||||||.|.|
eeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald

IALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
|.|||...|. ||.  ||..||.||..|||.|.||.||..|..
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1414-1647 6.7e-75 246.9 In-house 1-234 (235) alignment 
Range on Protein: 1414-1647
Range on HMM: 1-234/235.0
NKYLNRFQQITVYDDNRIILtpnpN----LYMcereYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECiKNKWCEQYWPRA
||  ||...|..||..|. |    .           ||||.|..||....||||||||. .|..||||..|||.   |||||. .|  ... |.||||..
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek.grekcaqYwpee

LMEEEKFGPFIVTLT-NVA-NHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVP---KPLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAID
  |....| . |.|. ..  .. ..|.| |..   ..........|.|.|.|||||||   |.||.| ..|  . ....||..|||||||||||||.|.|
eeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald

IALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
|.|||...|. ||.  ||..||.||..|||.|.||.||..|..
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPRK_pd Subfamily PTPRK 1375-1687 3.2e-74 244.6 In-house 4-313 (314) alignment 
Range on Protein: 1375-1687
Range on HMM: 4-313/314.0
ISINDLVNHIAKYSN----KFEDQYLRLYTGndrpCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGPMVN
| ..||...||.        | ..|  |. |      .   |||.  ||...|  ||  |..|..  .    . .||||..||.|  ...||.||||. .
irvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqe

TLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRalmEEEKFGPFIVTLTNVANHPSFTIRSLNVII-PDGSNDSHTLTQYHLTSWPDHGVPK---
|..|||||...|.   |||||. .|  . | | .|||    . |..|.. |.| ..  .  . .| ..|     | .. ... |.. ..||||.||.   
tvkdfWrlvydencasivmltelvevgrvk.ClkyWPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsat

PLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPADKFATK
 ||.| ..| ..  ...|.|.|||||| ||||||||||| |. ..||||||.  .|  ||.... ||.| .||.|..|... |. . ||| ||. .| . 
gllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvil.eaclcgetaipvsefkal

LQELKEIDSSTGCSGLQSQFE
  | ...|. |  | |. .|.
ylesirldpqtnssqlkeefq
subfamily_PTPRA_pd Subfamily PTPRA 1384-1686 4.7e-74 244.2 In-house 27-330 (330) alignment 
Range on Protein: 1384-1686
Range on HMM: 27-330/330.0
IAKYSNKFEDQYLRLYTGN-DRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLymCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQE
.|  ...| ...  | .|. .  . .   .|||  ||. .|  || .|.||..       | .|||||.||||   .||||.|||  .|. ||||.||. 
saddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGv..eesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweq

RPMHIVMLTDPKECIKNKwCEQYWPRALMeeEKFGPFIVTLTNVANHPSFTIRSLNVI-IPDGS--NDSHTLTQYHLTSWPDHGVP---KPLLSLHKQVM
. . |||||. ||  ..| |.||||   .    .|   |.. ..    ..|.| . |  .||..  ..|  ..|.|.||||| |||   . .|.| |.| 
ksativmltelkerkeek.caqywPdeGl..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk

ATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPADKFATKLQELKEIDSS
..   | ||| ||||||||||||||..|  ||.   |..||. ..|.|||.|| .||||. ||.|.. ..  |  . |.||. .  . ..||.|..  ..
klnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvll.eyylygdteldvsslekhlqklynkitg

TGCSGLQSQF
|   ||. .|
tdkigleeef
0040439 (Phosphotyrosine protein) phosphatases II 1405-1646 2.9e-73 241.8 In-house 2-242 (249) alignment 
Range on Protein: 1405-1646
Range on HMM: 2-242/249.0
PCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYMCEreYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECiKNKWCEQ
...|..  ||| .||.. |  || .|..|.. |.|. .   |||||||||| ....|||||||. .|..||||..|...  .|||||...|. ... |.|
eysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel.grekcaq

YWPRalMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPdGSNDSHTLTQYHLTSWPDHGVPKPLLSLHKQVMATWS-----PSEGPILVHCSAGVGRTGT
|||    .. ..| | |||..|  ....|.| | .    . ..|.| .... |.|||||||. . .| . . | ..     |..||.|||||||||||||
ywpl..ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

FIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
|||....||| ..|. ||.  .|. ||.||...||...||.||..|.
fiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1385-1647 9.9e-73 239.7 In-house 17-276 (288) alignment 
Range on Protein: 1385-1647
Range on HMM: 17-276/288.0
AKYSNKFEDQYLRL-YTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQER
|.  . |...|  |   ....  |.|   .|.  ||...|  || .|. |.  ..    . .|||||||||. ...|.||||||. .|. |||.|.....
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkklee..eagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

PMHIVMLTDPKECIKNKwCEQYWPRAlMEEEKFGPFIVTLTNVANHPSFTIRSLNVIipdGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWS
   |||||.  |  |.| ||.||| |  .....| . |||... .  .|. |.| .     ...  ..|||. ..|||||||.   ||| | .||  . .
tstivmltelveggktk.CeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

PSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
   |||.|||||||||||||||.| .... ..| ..|.||.|..||.||. .|||| ||.|..... 
adtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
0045098 (Phosphotyrosine protein) phosphatases II 1397-1647 1.4e-71 236.4 In-house 16-269 (278) alignment 
Range on Protein: 1397-1647
Range on HMM: 16-269/278.0
RLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIIltpnpnlymcerEYINASYIDGYssSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKEC
 | .|.   .|..   .|...||. .|  || .|..            .||||||||||  ..||||||||. .|.|||||..|...  .|||||. .| 
llllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

IKNkWCEQYWPRalMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIP---DGSNDSHTLTQYHLTSWPDHGVP-----KPLLSLHKQVMATWS--------
 ..  |.||||   .. . .|.| |||... ... .|.| |.|.     . .. |...|..|...|||||||     |..|.| ... .  .        
gre.kcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

-----PSEGPILVHCSAGVGRTGTFIAIDIALEQAdrEGVVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDAVF
     .|.||.|||||||||||||..|... ||.   ||.||.  .|. ||.||.  .||.|.||.||.... 
slllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefll
subfamily_Ptp69D_pd Subfamily Ptp69D 1389-1670 1.6e-71 235.9 In-house 22-305 (307) alignment 
Range on Protein: 1389-1670
Range on HMM: 22-305/307.0
NKFEDQYLRLY-TGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYmcEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHI
  ..  | .|  .  |. ..|.  .||.  ||...|. .|..|..|.. .     . .|||||.| ||  ..|||| |.|. .|. ||||.|..     |
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLTDPKECIKNKwCEQYWPRAlmEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPD----GSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWS
|||.. .|  ..| |..|||    .| ..|  .|.| .  .|. ..||.|.|   .      .||. ..||| |.|.|  ||.    || | .||    .
vmlsnlteknrkk.cakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyk

PSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPADKFATKLQEL
 ...||.|||||||||.|.|.|.|. |.|   |  |||  .|  ||.||  .|| |.|||||. |.  ...  |.|..  |... ....|
lnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyrall.dyssygdtdedvddledaierl
subfamily_PTPRG_pd Subfamily PTPRG 1376-1664 5.4e-71 234.5 In-house 2-300 (563) alignment 
Range on Protein: 1376-1664
Range on HMM: 2-300/563.0
SINDLVNHIAK-YSN---KFEDQYL---RLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYMCErEYINASYIDGYSSSNKFIATQGPM
 ......|.|. ...   .|. ..    .  . .| ...     |||  ||  .|. ||  |. |.| |.      .||||.|||||  |..|||||||.
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgpl

VNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRalMEEEKFGPFIVTLTNVANHPSFTIRSLNV---IIPDGS--NDSHTLTQYHLTSWPDHG
 .|. ||||.||...   |||.|. .|  ..| |..|||.   | |..| . |||..   . . |.|.| .   .. ...  .. .. .||| |.|||||
kdtfddFWrmiWeqnvaiivmitnlvergrrk.cdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg

VPK---PLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPA
||.   | |.  |.  |.     |||.||||||||||||.|..|  |.|  .| .|.. |.. ..| ||  .||| .||.|||||.  |.| ..|||. |
vPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall.eaiasketella

DKFA
..  
eqve
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1374-1687 5.7e-71 234.0 In-house 5-315 (315) alignment 
Range on Protein: 1374-1687
Range on HMM: 5-315/315.0
PISINDLVNHIAK----YSNKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGPMV
|| ...|. ..|.      | |...|  .  |. .|  |    |||  ||. .|  ||  |. |    |    . .|.||..||||.  ...||.||| |
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllen..dphsdyvnanfidGynkkrryiaaqgpnv

NTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRAlmeEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDgsnDSHTLTQYHLTSWPDHGVPK---
... |||||...|   .|||||.  |  |.| .|.|||     .  .|.. ||. .   .  .|.|.| |.  |   . ... |.|.||||| ||||   
asvkdfwrlvfeedigkivmltnlvegekrk.aekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgd...nirevvqlhytswpdmgvpkyti

PLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPADKFATK
||. |...|.     | |.|.||||||||||||||..|  |.||. | ..|.  .....||.|.||||...|| |..||.. ||.. |.| |  | .  .
plmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall.etfvcgdtsiaqdlylqr

LQELKEIDSSTGCSGLQSQFE
 . |      || . || |||
ydsllapspdtgstllqeqfe
0042113 (Phosphotyrosine protein) phosphatases II 1406-1646 3.5e-70 231.5 In-house 1-239 (245) alignment 
Range on Protein: 1406-1646
Range on HMM: 1-239/245.0
CTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYMCEreYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQY
..|..  ||| .||. .|  ||..|..|.| .. . .   ||||||.|||  ..||||||||. .|..||||..|...  .|||||.. |  ..| |.||
ysvallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvk.caqy

WPRalMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIpDGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWS-PSEGPILVHCSAGVGRTGTFI
||    |. ..| |.|||... .....|.| |.|   .|.. |.. ..|| ..|||||||     ||.... |    . .|.||.|||||||||||||||
wpl..gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

AIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
|....|||...|. |..  .| .||.||...|||..||.||..|.
aaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1389-1647 6.5e-69 227.4 In-house 27-287 (298) alignment 
Range on Protein: 1389-1647
Range on HMM: 27-287/298.0
NKFEDQYLRLYTGND----RPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPnlYMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERP
 ...... || ....       .|. ..|||  ||...|  .|  |..|. .      | .|||||....|. .| |||||.|...|..||||....|  
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedi

MHIVMLTDPKECIKNKwCEQYWPRAlmEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSnDSHTLTQYHLTSWPDHGVPKP---LLSLHKQVMAtWSP
  |||||. .|  | | ...|||    ..|..| . |.| .  ..  ...| |.|   . . ..... | | |||||.|||.    .| | ..| | .  
gtiVmltnleeldktk.yhkywPde..gketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqq

SEG--PILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
  |  |..|.|||||||.|||||||  ||.. .| |||.  .|..||..|...||| .||||...|| 
qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1382-1697 6.8e-69 227.3 In-house 15-322 (515) alignment 
Range on Protein: 1382-1697
Range on HMM: 15-322/515.0
NHIAKYSNKFEDqylrLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTP-NPNlymCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIW
.| . .|..| |    |   |  | ||   . |   ||.. |  || .|..|   | |    . .|.||||| .. . . .||.|||   .. |||||..
rhttlfseefhd....lpgpniypqtvaqeeinfkknryknilPydsvrvklevindn...PhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvl

QERPMHIVMLTDPKECIKNKwCEQYWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDgsnDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMA
||..  |.|.|. ||  | | | .|||    .  ||| . | |  .      ..| |.|.  |   ||.|.||.|.| |||.||||    || | |.| |
qenvttiamvtklkegdkik.cgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgd...dsrtvtqfhfteWPdkGvpkhtssllklikevka

TWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPADKFATKLQELKEIDSST
  .  . |...|||||||||| .|.||  . .|    .||.  .|. .||.|...||| .|| |...||  | .   .| ||  .|. .||.|.      
dhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl.edllwrntlipvihftdhlqdlhssgdgr

GCSGLQSQFELLSQVTPDLD
| | .  .|. |  ..||  
grskmtkefqtlkslcpdpp
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1382-1687 1.6e-67 222.6 In-house 16-313 (315) alignment 
Range on Protein: 1382-1687
Range on HMM: 16-313/315.0
NHIAKYSNKFEDqylrLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQ
 | | .|..| |    |   .  . .|. ...|   ||.. |  .| .|..|    .    ...||||||| .. . . .||.|||   .. ||||...|
rhtalfseefhd....lpdPdiyrqrvaretinfkknryknilPldsarvklevidd..sPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlq

ERPMHIVMLTDPKECIKNKwCEQYWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLnviIPDGSNDSHTLTQYHLTSWPDHGVPKP---LLSLHKQVMAT
|..  |||.|. .|  | | | ||||    .  .|| . |.| ..      ..| |   .   |..|.|.||...| |||.||.|    || | |.| | 
ekvttivmvtkkqegdkik.crqywPdrkadsvefGsikvellsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad

WSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPADKFATKLQELKEIDSSTG
  . | ..|||||||||||| .|.||  ..|. |. .||.  .|. ||..|...||| ..| |..|||  | .   .| |.  .|. .||.|.   . .|
ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl.edllwrntlilvihftdhlqdlhtsvdgsg

CSGLQSQFE
 | .  .||
rskmtkefe
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1408-1670 1.9e-67 222.9 In-house 55-310 (319) alignment 
Range on Protein: 1408-1670
Range on HMM: 55-310/319.0
VGYTDENKYLNRFQQITVYDDNRIILTPNPNLymCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTdpkecikNKWCEQYWP
    |.||  ||. .|  .| |.. | .         .|||||...|| . .|.||.|||. ||||||||.||. .   ||.||       .. | ||||
fanldqnkdknriinilafdknvvklerliGe..efsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.......kdkcsqywp

RALMeeEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWS--PSEGPILVHCSAGVGRTGTFIA
      .| . | | .. | .   ...|....      .|   .||.|.  |||.|||.   .|. | |.|    |    . .|.|||||||||||..|.
lkiv..ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyiv

IDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFSETIIGgETEIPADKFATKLQEL
.|. |.. ..|  ||.  .|. ||||| ..|| | || |.. |.  | ..|  ...    | . |.||
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg.hsdvampdfpayleel
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1389-1647 2.2e-67 222.2 In-house 15-273 (281) alignment 
Range on Protein: 1389-1647
Range on HMM: 15-273/281.0
NKFEDQYLRLYT-GNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYMCerEYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHI
. |  .|  |.  |.| . |  ..|||.  ||.. |. ||  |. .||| .  ..  .||||....||.. ...||||||. ..|..||...|...   |
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenknt..DYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

VMLTDPKECIKNKwCEQYWPrALMEEEKFGPFIVTLTNVANHPSFTIRSLNViiPDGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWSPS-E
||.|   |  | | | .|||    .| |.| ..|. |. ......  | ...     |... ...| . |.|||||||.    ||. .|.|. . ... .
vmvtreieagklk.ChrYWP.ddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk

GPILVHCSAGVGRTGTFIAIDIALEQADRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
 |...|||||||||||.||.| .......|   .|.  .|. ||..|. ||||. || |.. || 
aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1410-1670 1.6e-66 219.7 In-house 21-274 (284) alignment 
Range on Protein: 1410-1670
Range on HMM: 21-274/284.0
YTDENKYLNRFQQITVYDDNRIILTPNPNLymCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTdpkecikNKWCEQYWPRA
  |.||  ||. .|  .| |.. | .         .|||||.| || . .|.||||||. ||||||||.||. .   ||.||       .. | ||||  
nldqnkdknrighilafdknvvklerliGe..efsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.......kdkcsqywplk

LMeeEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWS--PSEGPILVHCSAGVGRTGTFIAID
    .| . | | .. | .   ...|....      .|  ...|.|.  |||.|||.   .|. | |.|    |    . .|.|||||||||||..|..|
iv..ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

IALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFSETIIGgETEIPADKFATKLQEL
. |.. ..|  ||.  .|. ||||| ..|| | || |.. |.  | ..|  ...    |.. |.||
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg.hsdvalpdfpayleel
0037934 (Phosphotyrosine protein) phosphatases II 1406-1646 1.4e-65 216.6 In-house 2-238 (243) alignment 
Range on Protein: 1406-1646
Range on HMM: 2-238/243.0
CTVGYTDENKYLNRFQQITVYDDNRIILtpnpnlymCEREYINASYIDGYsssNKFIATQGPMVNTLAD----FWRLIWQERPMHIVMLTDPKECiKNKW
....   ||.  ||.. |  ||..|..|            ||||..|...   ...||||||. .|..|    |||..|...  .|||||...|  . . 
fsiallpenlsknrysdilpydhsrvkl........egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvEl.grek

CEQYWPralmEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMAT--------WSPSEGPILVHC
|.||||    .|. .|.|.|||... .....|.| | .  .| .. ... ..|| ..|||||||    .||.....| .           .|.||.||||
caqywp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC

SAGVGRTGTFIAIDIALEQAdreGvVDIAGIVNRLRQQRMK-MVQTLDQYVFLHDAV
|||||||||.||... |..    | ||.  .|..||.||.  .|||..||.||..|.
saGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1666-1913 4.4e-65 214.5 In-house 6-282 (287) alignment 
Range on Protein: 1666-1913
Range on HMM: 6-282/287.0
KLQELKEIDSSTGCSGLQSQFELLSQVTPDLDDATEDNAGEDLAKNQG----------------SNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKM
|. |. . .  .|  | . || .| ||| . |. | . | ..  ||.                  . | | .|  ||..|||||||.||| ||||.|||.
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkl

IVDYKVSAIVMLCG----EEDCCYPYWTGLS--THDDFVVEIANEIKSNGYIERMLNVESRN-------VLQLQVTDWPQDGVVREPRTVLQVIDDVIHR
| | .|.||||||     .|. || ||.  .  .  .. .|. || ...||||| |.|. .|       | | |.|.|.. | | ||.|.| ||.. .. 
iddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQMNK
|.| | ...|||||||| ||...|.. .....|| |||.||||| |  |  |||.| | |||. |.|.. .||.  .
qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_PTPN6_pd Subfamily PTPN6 1408-1646 1e-64 213.5 In-house 48-293 (306) alignment 
Range on Protein: 1408-1646
Range on HMM: 48-293/306.0
VGYTDENKYLNRFQQITVYDDNRIILTpNPNLYmcEREYINASYIDG--YSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQY
 |   |||  ||.. |  .|..|.||. .|...  . .||||.||..   .|....||||| . .|..||||..|||    |||.|   |  |.| | .|
egakpenkeknryknilPfDhtrvilk.epsvp..gsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkek.CarY

WPRALMEEEkFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPKP---LLSLHKQVMATWSPSE----GPILVHCSAGVGRTG
|| . ..|| .|   || ..  .. ....|.|.|   . ....... ||| .|||||||||    .|.. ..| .  . .|    |||.||||||.||||
WPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtG

TFIAIDIALEQADREGV---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
||| ||| |..  ..|.   .||  .|. .|.||  .||| .|| |.. |.
tfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1408-1648 1.5e-64 212.6 In-house 3-240 (250) alignment 
Range on Protein: 1408-1648
Range on HMM: 3-240/250.0
VGYTDENKYLNRFQQITVYDDNRIILTPNPnlYMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNkwCEQYWP
|.   .||  ||. .|  .|  |..| ..      | .|||||...||. .. |||||||...|. ||||....|    |||||. ||  |.  ..||||
vakkpqnkeknryadiialdssrvvLekek..gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt..yhqywP

RAlmEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDgSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWSP-SEGPILVHCSAGVGRTGTFIAI
    . ||.|   |.| .  ..  .|.| | .      .|. .. |.| ..||| |||.     | | |.| |.     ..|..|.|||||||.|.||||
ve..kaekyGdvtvsllskeefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiai

DIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFS
|  ||.. .| |||.  ....||..|...|..|.||||.. ..  
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1712-1911 2.9e-64 211.7 In-house 73-285 (290) alignment 
Range on Protein: 1712-1911
Range on HMM: 73-285/290.0
QGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTGLST--HDDFVVEIANEIKSNGYIERMLNVESRN
  .|.| | ..  ||..||..|..|.|..||..||||.|.. ||..||||.     ... |. ||.  .|   . | ... || . |.|||| |.|...|
DCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknkn

-------VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQY
       | |.|.| |...| | .| |.|.||  ... | | | ...||||||||.||.|.|.. .....|| |||.||||| |  |  ||| |.| .||
sagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqy

TSIYDVIDMYLQM
  |....  ||. 
qgifqivltylds
subfamily_PTPN12_pd Subfamily PTPN12 1400-1647 6.2e-64 210.7 In-house 26-274 (290) alignment 
Range on Protein: 1400-1647
Range on HMM: 26-274/290.0
TGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYmcEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKN
. .  . ..| ..||.  ||.. |  || .|. |. . .    . .||||..| | ... ..||.|||. .|| ||||.||. .   .||.    |  |.
aekvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

KwCEQYWPRALMEEEKFGPFIVTLTNVANHP-SFTIRSLNVIIPdgsNDSHTLTQYHLTSWPDHGVP---KPLLSLHKQVMATWSPSEGPILVHCSAGVG
| ||.|||    || .||.| |||..  .    |.||.|.|      ..|....|.| |.|||||||   |.||.| ..|  . . .. |..||||||||
k.CerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvG

RTGTFIAIDIALEQADREGV---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
|||| ||||.. |.  .| .   .|.  .| .||.||  .||| .||.... || 
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykava
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1390-1658 2e-62 205.6 In-house 9-273 (283) alignment 
Range on Protein: 1390-1658
Range on HMM: 9-273/283.0
KFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlymcerEYINASYID---GYSSSNKFIATQGPMVNTLADFWRLIWQERPMH
|   . |.  .  |.....  .||||  ||.|.| ..| .|. | ....      .||||..|     |  ..|.|..|.|. .|  |||.....|.   
klfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

IVMLTDPKECIKNKwCEQYWPRAlmEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPKPLLSL--HKQVMAT-WSPSE
|||||  .|  . | | ||||.     |..|.| ||| .   . ||.|. | .     ....  |. | .  | . |   .. ||    .|..      .
ivmltklqedlrik.CsqyWPkr..GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskk

GPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFSETIIgGETEI
|||.||||.|.|||..|||.  ....|  | |||.  .|. .|.||| .||||||| ..|..|. ...  |.|.|
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalc.gdtqi
Pkinase_Tyr Protein tyrosine kinase 581-838 5.1e-61 195.9 Pfam-A 1-259 (259) alignment 
Range on Protein: 581-838
Range on HMM: 1-259/259.0
IEVGERIGSGSFGTVYKGKWH-------GPVAVKKLnVSNPTEQQMQAFKNEVAVLMKTRHANILLFMGWTS-KPRLTIVTQWCDGSTLFSHIHVL-EDR
.|.|...|.|.||.|..|...         ||||.|  .. .|.....| .|.....|..| ||. ..|  . . .| |||....| .| ....   ...
lelgkklGeGafGeVvegtlkgekekkevkVavKtl.keeaeeeekeefleeakimkklkhenivkllgvctkeepllivteyvegGdLlkfLrkkekek

FEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVKTRWDGNEKVRQPTGSILWMAPEVIRMEEpdpYTFYCDVYSFGVVVY
... ...... | |.|..||..|...|||| . |..|.....|||.|||||   .. |  .| .. . .. |||||... ..   .|   ||.||||...
ltledllsfalqiAkGmeyLeskklvHrdLaarNvLleenkvvkisDfGLardiekddyykkkekaklpvkWmapEslkekk...ftsksDvWsfGvllw

ELIS-GQLPYPHVqDRDQILFMVGRGFLRPDPssarKDTPKSFKQLCIKCCQFEKDDRPLFHQILADL
|... |. |||.. .  ..| .. .|   . |    ...|.....|  .|.. |...|| |.... .|
Eiftlgespypgl.sneevleklkegkrlekp....encpeelyelmkqCweeepekRptfkelvekl
Pkinase Protein kinase domain 582-836 5.4e-61 195.9 Pfam-A 2-256 (260) alignment 
Range on Protein: 582-836
Range on HMM: 2-256/260.0
EVGERIGSGSFGTVYKGKWHGP---VAVKKLNVSNPTEQQMQAFKNEVAVLMKTRHANILLFMGWT-SKPRLTIVTQWCDGSTLFSHIHvLEDRFEMYKI
|..|..||||||.|||.|...    ||||.|. ..  ... ..  .|...| | .| ||. ....  .| .| .|.....|..||....  . .... .|
elleklGsGsfGkVykakekktgkkvAvKilkkeeekskkektalrElkilkklnHpnivkllevfeekdelylvleyveggdlfdllk.kkgklseeei

IDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVKtrWDGNEKVRQPTGSILWMAPEVIRmeEPDPYTFYCDVYSFGVVVYELISGQ
 .|..|...|..||| ..|||||||..||.|... ..|| ||||| .      .||... .|.  .|||||..  . . ||  .||.|.||..|||..|.
kkialqilegleylHsngiiHrDLKpeNiLldekgelkiaDFGlakkl..eksseklttlvgtreYmAPEvll..kakeytkkvDvWslGvilyelltgk

LPYPHVQDRDQI--LFMVGRGFLRPDPSsARKDTPKSFKQLCIKCCQFEKDDRPLFHQILA
||... ...||   . .. .. |. | .   .......|.|. |........|. ...|| 
lpfsgeseedqlelirkilkkkleedep.kssskseelkdlikkllekdpakRltaeeilk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1415-1647 6.8e-61 200.7 In-house 29-265 (274) alignment 
Range on Protein: 1415-1647
Range on HMM: 29-265/274.0
KYLNRFQQITVYDDNRIILTPNPNLyMCEREYINASYIDGYSSSN-KFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALME-
.. ||...|   .  |..|... .    . .|||| || ||.  .  ..|||||..||.|||||.|.||.   |||||. ||  ..| |..|.| |    
qtknryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqk.CavyfPdaedye

-EEKFGPFIVTLTNVANHPSFTIRSLNVIIpdGSNdSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWSPS---EGPILVHCSAGVGRTGTFIAIDI
 .|..| . .. ... ..  ...|.| .     .. ..... |  |.|||| .|.   .||.| ..|  . . .    .|..||||||.|||| ||||.|
iserygdveikvekiverndysvrklvlky..ler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
|. | ..|.|||. .||  ||..|  |||| .|| ..| |. 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1385-1663 2.5e-60 199.1 In-house 22-296 (297) alignment 
Range on Protein: 1385-1663
Range on HMM: 22-296/297.0
AKYSNKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSsnKFIATQGPMVNTLADFWRLIWQERP
 . .. |....| | . | .| ||     |   .|.. |  || .|..|    .    . .|.|||.. |.    ..|.|| || .|.||||.....|..
nrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnd..dpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqv

MHIVMLTDPKEciKNKWCEQYWPRALMEEekFGPFIVTLTNVANHPSFTIRSLNVIIPDgSNDSHTLTQYHLTSWPDHGVPK-----PLLSLHKQVMATW
  ||||.| .|  ..| | .||.   . .  ||   |.|. |..   |  |.|.|   . .   . . ||. ..|||. |..      || | ..|  ..
stivmlnddne..rdkkcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgk.akarrvvkqyqfveWPdkaverkdsassllklisevrkdf

SP-SEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPADKF
|  .|||.||||.||||||| ...||  . .| ||  ||| |.|..|||.|...||| .|| |.. ||  |...  .|.|.|. |
sqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavl.eallsedtriqasyf
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1375-1687 7.2e-60 197.8 In-house 5-324 (325) alignment 
Range on Protein: 1375-1687
Range on HMM: 5-324/325.0
ISINDLVNHIAKYSNKFEDQYL----RLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGPMVN
|.. .||.|. |   . .| .      | . .    .|    |||  |||. .  .| .|..|    .    . .||||||.  .   . |.|.| |. .
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkd..dpssdyinasylrddkkkdvflaaqaPlta

TLADFWRLI--WQerpMHIVMLTDPKECiKNKWCEQYWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSnDSHTLTQYHLTSWPDHGVPKP-
|. |.|||.  |.     .|....  .  ... | .|||. . .  .||.. | |  . .   .  | |.|  ...  .. .. |..| ||.| ||.|  
tindlWrlvldWr...csvvvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrp

--LLSLHKQV------MATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVfSETIIGGETEIP
  |.|. . |      . . . . .||||||||||||||.||..  ||..   |  ||| | |..||..| .||.| |||.....|.  |... |.|..|
atlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal.veaymsgntdvp

ADKFATKLQELKEIDSSTGCSGLQSQFE
   | .||  |.| .  |    .. .||
vssfeaklsslqernpltqklniekefe
subfamily_PTPN9_pd Subfamily PTPN9 1411-1647 2.2e-59 195.9 In-house 39-287 (297) alignment 
Range on Protein: 1411-1647
Range on HMM: 39-287/297.0
TDENKYLNRFQQITVYDDNRIILTPNPNLYMceREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRAL
.  |   ||.. .  ||. |. |.  ..  .   .||||...|||   . |||||||. .|  ||||..|... . ||| |   |  . | | ||||   
lranleknrytdvlcydetrvvlakvdedea..sdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlk.cgqyWplee

MEEEKFGPFIVTLTNVANHPSFTIRSLNVIIpDGSNDSHTLTQYHLTSWPDHGVPKPL---LSLHKQV-----------MATW--SPSEGPILVHCSAGV
 . ..|| . |.  .| ..  ...|.|..      ..| ..| . ..||||.|||.     | . ..|            ..|   ||. ||.||||||.
essaefgdlsvsnveveeeedykvrvleikn.vkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
|||||||..||.|.. ...|.||.   |..||.||  ..|| .||.| . || 
GrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl
subfamily_PTPN3_pd Subfamily PTPN3 1394-1647 1.2e-58 193.3 In-house 20-272 (280) alignment 
Range on Protein: 1394-1647
Range on HMM: 20-272/280.0
QYLRLYTG-NDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlymcerEYINASY----IDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIV
|. .||   ... ...    ||   ||.. |. ||. |..|. ...      .||||.|    |.. . .|..||||||. .| .|||...|...   ||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset......dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLTDPKECIKNKwCEQYWPRaLMEEEKFGPFIVTLTNVANHPSFTIRSLNViIPDGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWSPSEGP
|||.  |  . | | ||||.   .| ..| | |.... ... |. .| | .     ........|   ..|||||||.    .|.. ..| .. | .| |
mlttlverGrvk.ChqyWPe.tedeleygefsvkcekedetksyvlrelvl.kdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeeP

ILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
..||||||.|||| .|....||   ...  | .  || ..|.||. .||| .|| |. .|..
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
0050432 (Phosphotyrosine protein) phosphatases II 1662-1911 1.1e-57 191.0 In-house 24-301 (308) alignment 
Range on Protein: 1662-1911
Range on HMM: 24-301/308.0
KFATKLQELKEIDSSTGCSGLQSQFELLSQVTPdLDDATEDNAGEDLAKNQ---------------GSNSYTNPSFTAGY--HDKKAFIIAQSPMENTAR
.  . |. || ... .. ..|. .|| | .|.| | . .  .  |   ||.               ....| | |.  ||  . ...||..|.|..||  
lklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntve

DFWKMIVDYKVSAIVMLCGEEDC----CYPYW-----TGLSTHDDFVVEIANEIKSNGYIERMLNVES------RNVLQLQVTDWPQDGVVREPRTVLQV
|||.|. ...|. ||||. ...     |..||      |  ....|.|.. .| . ..|. | | ..       | | ... |.|| .||  .|. .|. 
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldf

IDDVIHRQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQM
.. | ...   .|||.|||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|.|||  .|... .||. 
lelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1415-1665 1.6e-57 189.9 In-house 49-293 (439) alignment 
Range on Protein: 1415-1665
Range on HMM: 49-293/439.0
KYLNRFQQITVYDDNRIILTPNPNLymCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKnkwceqYWPRAlmEEE
.  ||..... .|  |..|   | .      |||| ||.||   . .||||||  .|  |||||..... ..|||||.  |  |      |||    .| 
qtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk......ywpsd..aev

KFGPFIVTLTNVANHPSFTIRSLNVII-PDGSNDSHTLTQYHLTSWPDHGVPKPLLSLHKQVM----ATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQ
 .|  .|      . | ..|| ..|.   | ..  .|. |.| ..|||. ||     . . .     |  .   ||..|||||||||||| ||.||||||
cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq

ADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPADKFAT
   |  ||| |||. ||.|| .|||.| ||||...||. | |. |.. .  |.|  
lklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl.edivyGdiavtidefkk
subfamily_PTPN13_pd Subfamily PTPN13 1405-1647 4.9e-57 188.3 In-house 28-266 (273) alignment 
Range on Protein: 1405-1647
Range on HMM: 28-266/273.0
PCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlymcereYINASYIDGYSSSNKF--IATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwC
 |.|| ..|||  ||....  ||. |..|  . .       |||||.|      ...  ||.|||. .| .|||...|. .   |.|.|  ||  | | |
tcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk.c

EQYWPRALMEEEKFGP-FIVTLTNVANHPSFTIRSLNVIiPDGSNDSHTLTQYHLTSWPDHGVPKPLLSLHKQ--VMATWSPSEGPILVHCSAGVGRTGT
..|||    .. |    . |.| .| .. .|..|.|.|.    |..|. ... ....|||||||.  ..| .    ...   ..|||.||||||.||.||
hrywPesknkklkvsnrlevellkvqkldgfvvralavk.dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGt

FIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
.|.||..|.  .|.  .|.  ||..||.||  .||| |||.| . |. 
litidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail
0051299 (Phosphotyrosine protein) phosphatases II 1654-1909 6.3e-57 188.6 In-house 1-286 (288) alignment 
Range on Protein: 1654-1909
Range on HMM: 1-286/288.0
GETEIPADKFATKLQELKeidsSTGCSGLQSQFELLSQVTPDlDDATEDNAGEDLAKNQ--------------------GSNSYTNPSFTAGYHDKKAFI
|.|||......  ...|.     .| .||. .|| | ...||  . .  .  | | ||.                    ....| | |.  ||. |..||
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

IAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYW--TGLSTHDDFVVEIANEIKSNGYIERMLNVE----------SRNVLQLQVTDWPQD
..| |..||  |||.|. ...|. ||||.....     |..||   |  |..|..|.. .| . ..|. | | |.          ||.| ....|.|| .
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYL
||   |. .|. . .|.. ..  ||||||||||. |.|.|... . . ||| ..||.|||... | .|. .||.|.|.|||  .|... .||
gvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 1681-1911 6.3e-55 181.9 In-house 1-276 (284) alignment 
Range on Protein: 1681-1911
Range on HMM: 1-276/284.0
GLQSQFELLSQVTPDLD-DATEDNAGEDLAKNQ---------------------GSNSYTNPSFTAGY-----HDKKAFIIAQSPMENTARDFWKMIVDY
||. .|| | ..|..|  . .  .. | | ||.                     ....| | |.  ||     . ||.||..| |..||  |||.|. ..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KVSAIVMLCGEEDC----CYPYWTGL---STHDDFVVEIANEIKSNGYIERML-------NVESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK
.|. ||||.....     |..||       |..|| |.. .| . ..|. |.|       . ||| | ....|.|| .||  .|. .|. ...| . ...
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQM
  ||||.|||||. |.|.|... . . ||| ..||   .|||... | .|. .||.|.|||||  .|... .||..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0036941 (Phosphotyrosine protein) phosphatases II 1670-1912 8.6e-55 181.5 In-house 3-280 (297) alignment 
Range on Protein: 1670-1912
Range on HMM: 3-280/297.0
LKEIDSSTGCSGLQSQFELLSQVTPdLDDATEDNAGEDLAKNQGS----------------NSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDY
|| ...... ..|...|| | .. . | . .  .  | | ||. .                ..| | |.  ||. |..||..| |..||  |||.|. ..
lkllekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

KVSAIVMLCGEEDC----CYPYW----TGLSTHDDFVVEIANEIK--SNGYIERMLNVES------RNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ
.|. ||||. ...     |..||     .  |..||.|.  .. .  ...|. | | |.       | | ....|.|| .||   |...|. |. | ...
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

QKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQMN
... .||||.||||. |.|||... . . |.| .    || ||.... | .|. .||||.|||||  .|... ..|. .
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0047943 (Phosphotyrosine protein) phosphatases II 1672-1909 2.2e-54 180.1 In-house 4-272 (273) alignment 
Range on Protein: 1672-1909
Range on HMM: 4-272/273.0
EIDSSTGCSGLQSQFELLSQVTPdLDDATEDNAGEDLAKNQG----------------SNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKV
 .....| ..|. .|||| ...| | . .  .  | . ||.                 ...| | |.  ||. |..||..| |..||  |||.|. ...|
llekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

SAIVMLCGEEDC----CYPYWTGLS-----THDDFVVEIANEIKSNGYIERMLNVES------RNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI
. ||||. ...     |..||         |...| |.. .| . ..|. | | ...      | | ....|.|| .||   .  .|. |..| . ....
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYL
 ..||||||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|.|||  .|... .||
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 1680-1912 1.5e-53 177.5 In-house 18-279 (317) alignment 
Range on Protein: 1680-1912
Range on HMM: 18-279/317.0
SGLQSQFELLSQVTPDldDATEDNAGEDLAKNQG--------------------SNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIV
 .|...|| | ....|  . .. .  |   ||.                     ...| | |.  |.. |..||..|.|..||  |||.|. ...|. ||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLCGEEDC----CYPYW--TGLSTHDDFVVEIANEIKSNGYIERMLNV------ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiG-GGPVV
||. .|..    |..||   .  |..||.|.. .|.. .|.. | | |      ||| | ... |.|| .||   |...|. .. | . ..  . ||||.
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvl

VHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQMN
||||. |.|.|... . . |||.. || |||... | .|. .||||.|.|||  .||.. .||. .
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0039614 (Phosphotyrosine protein) phosphatases II 1665-1912 2.1e-53 177.1 In-house 17-292 (297) alignment 
Range on Protein: 1665-1912
Range on HMM: 17-292/297.0
TKLQELKEIDSSTGCSGLQSQFELLSQVTPDlddATEDNAGEDLAKNQGS---------------------NSYTNPSFTAGYHD-KKAFIIAQSPMENT
. |  |. ..  .....|. .|| | ...||    .. .  |   ||. .                     ..| | |.  ||.  ...||..| |...|
svldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

ARDFWKMIVDYKVSAIVMLCGEEDC---CYPYW-T--GlsTHDDFVVEIANEIKSNGYIERMLNV----ESRNVLQLQVTDWPQDGVVREPRTVLQVIDD
  |||.|. ...|..||||. ....   |..|| .  |  |..||.|.  .... .||. | |.|    ||| | ..|.|.|| .||   ....|.... 
vedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflel

VIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQMN
| .....  .||||.||||. |.|.|...   . |||.. || |||... | .|. .||||.|..||  .||.. ..|. .
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPN23_pd Subfamily PTPN23 1403-1648 4.6e-53 174.9 In-house 34-278 (288) alignment 
Range on Protein: 1403-1648
Range on HMM: 34-278/288.0
DRPCTVgyTDENKYLNRFQQITVYDDNRIILTpnpnlyMCEREYINASYIDGYSS-SNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKw
.| ...     .   ||.. |  || ||. |         . .|||||.. . |. . .|||||.|. .||.|||.......   ||||....|  |.| 
krsiai..aklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpk.

CEQYWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDgSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMA----TWSPSEGPILVHCSAGV
...||| .  | .|||.. ||| .| . . .  | |.. . | ..  ....  .|||||..|||.    || . ..| .    .  .|. |..|||||||
vdrYwPedkgetvkfgdlsvtlksvretethvervlkletld.adavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGv

GRTGTFIAIDIAL-EQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFS
||||.|  .  |. |   ..|..||  .|.|||.||  |||. .|. |. .||  
gRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
0045450 (Phosphotyrosine protein) phosphatases II 1665-1909 1.1e-52 175.0 In-house 12-304 (307) alignment 
Range on Protein: 1665-1909
Range on HMM: 12-304/307.0
TKLQELKEIDSSTGCSGLQSQFELLSQVTPD-LDDATEDNAGEDLAKNQ---------------------GSNSYTNPSFT--------AGYHDKKAFII
.||  |. ..  .. .||. .|| | .||.. |.. .. .  |   ||.                     ....| | |.          ||. |..||.
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

AQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYWT---GLSTHDDFVVEIANEIKSNGYIERMLNVE-------SRNVLQLQVTDWPQDGVV
.|.|...|  |||.|. ...|..||||......    |..||    .  |...|.|.  .| . .||. | |.|.       || | ... |.|| .|| 
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvp

REPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYL
  . ..|. |. | . ...  .||||.||||. |.|.|...   . |.| ..||.   ||.... | .|. .||||...|||  .|... ..|
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1408-1647 1.9e-52 172.9 In-house 14-261 (270) alignment 
Range on Protein: 1408-1647
Range on HMM: 14-261/270.0
VGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSS-NKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYW
.  .  .| |||...|      |..| .  .    . .|||| |. |.... .|.||..||. .|| .|||.||.|.   |||.|. .|  ..| ||.||
lpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkk.CerYW

PRALME--EEKFGPFIVTLTNVANHPSFTIRSLNVIiPDGsnDSHTLTQYHLTSWPDHGVPKPL---------LSLHKQVMATWSPS--EGPILVHCSAG
|    |  . ..|   |. .. ...  . .. |..   .|  ... |. .. ..|||||||.           |.. ..| .. .    ..|.|||||||
paepkekvkledgkikvlalseekeegyiltrlrle.ekg..eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaG

VGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
||||||.||.|||..  .... ||.. |...||..||..||. .|| ||. || 
vgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1713-1911 3.9e-52 172.4 In-house 82-292 (298) alignment 
Range on Protein: 1713-1911
Range on HMM: 82-292/298.0
GSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED----CCYPYWTG--LSTHDDFVVEIANEIKSNGYIERMLNV-----
    | | ||  .|....|||..| |...|  |||.|........||||   |.     .  ||      |.... |.. .. .   .| | |.|     
eesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkke

-ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTS
 ..|.| ||..| ||. || .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..||..||||.| |||. 
ekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvf

IYDVIDMYLQM
||...  .|. 
iyeavlealds
subfamily_PTPRD_pd Subfamily PTPRD 1711-1914 5.9e-52 172.1 In-house 72-286 (564) alignment 
Range on Protein: 1711-1914
Range on HMM: 72-286/564.0
NQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE----DCCYPYWTGL--STHDDFVVEIANEIKSNGYIERMLNV---
.. .  | | ||  ||. .||.| .| |...| .|||.|. ....| ||||   |    . |  ||      |.....|.. .| . . |. | ...   
gdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkk

---ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQY
   |||.| | . |.||. ||  .....|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|| ..  | | |||
kssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQY

TSIYDVIDMYLQMNKA
  |...|  .|.. . 
iFiheailealacgnt
0051429 (Phosphotyrosine protein) phosphatases II 1445-1648 7.7e-52 171.9 In-house 5-223 (272) alignment 
Range on Protein: 1445-1648
Range on HMM: 5-223/272.0
EYINASYIDGYSS---SNKFIATQGPMVNTLADFWRLiWQERPMHIVMLTDPKECIKNKwCEQYWP----------RALMEEEKFGPFIVTLTNVANHPS
 ||||....|| .    .......||. .| |||||| ....  .||.|... |. ..| |..|||              ..  .| . |||. . ... 
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlk.cdrywpgirylhlpilddsaptilygalrvtllseellld

FTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVP-KPLLSLHKQVMAtwspsEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVD--------IAGIV
...| | ...  . .........| |.||||||| ..||.| ... .     .||.|||||||..||||..|... |.. ..| .||        ....|
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeav

NRLRQQRMKMVQTLDQYVFLHDAVFS
..||.||...||| .||.||..|.  
eelraqrpgavqteeqylflyealle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1413-1646 8.4e-52 170.7 In-house 2-235 (237) alignment 
Range on Protein: 1413-1646
Range on HMM: 2-235/237.0
ENKYLNRFQQITVYDDNRIILTPNPNLymceREYINASYIDGYSSS-NKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRAlM
|||  ||. .|..|| .|..|  . .      .||||.|..|.  . .|.||.|||. ..  |||...|||.   |||||   |  . | | .||| .  
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelk.chkywpst.d

EEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMAT--WSPSEGPILVHCSAGVGRTGTFIAIDIA
. . .| . |.|.   .   .|.||| .      ..   . ||..|||||.|||.    || . |...      .  || ..|||||||||| |. ||  
qpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam

LEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
| ||  . ||||   |  . ..|  ..|| |||||.|...
lrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_CG7180_pd Subfamily CG7180 1381-1649 3e-51 168.8 In-house 9-289 (296) alignment 
Range on Protein: 1381-1649
Range on HMM: 9-289/296.0
VNHIAKYSNKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYmcEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIW
|..  |.  ... ..    . .   |  |.  ||.  ||  ..  || ||..|.        . .||||.|.|..   ...| |..|. .|. .||||..
vdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGee..ksdYinavyvdsflkkkeyivteapkketvdefWrlvy

QERPMHIVMLTDPKECIKnkWCEQYWPRALmeEEKFGPFIVTLTNVANHPSFTIRSLNVIIP---------DGSNDSHTLTQYHLTSWPD-HGVPKP---
.|    .|.||.. .  |   . .|||     .|..|...| .... . . ..|| . .            . . .  ......|| |.  . ||     
deeisavvvLtktfdfak..mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstna

LLSLHKQVMA---TW--SPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFSE
|. | ..|          | |||..|..| |..|.| ..|||..||....|. ||. . | .||..| ..|.. ..| .. | .   
lielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1414-1647 3e-51 168.9 In-house 7-237 (239) alignment 
Range on Protein: 1414-1647
Range on HMM: 7-237/239.0
NKYLNRFQQITVYDDNRIILTPNPNLymCEREYINASYIDGYSSSNK-FIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRAlme
||  ||. .|  || .|..|    |      .||||||.  |  | | .||||| .  .  ||||..||||   |||||   |  |.| | |||| .   
nkaknryanivtydhsrvvleklsnd..phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkk.chqywpds...

EEKFGPFIVTLTNVANHPSFTIRSLnVIIPDGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQ
  |.  . ||| .      . ||.. |.   |  . . . |||.| |||.|||.    .| |....     |   | ..||||||||||.|. ||  | |
tskycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

ADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
| ..  |||   |. .|..| .|||| .||||.| ||.
akkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1414-1647 3.6e-51 168.6 In-house 8-238 (239) alignment 
Range on Protein: 1414-1647
Range on HMM: 8-238/239.0
NKYLNRFQQITVYDDNRIILTPNPNLymCEREYINASYIDGYSSSNK-FIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRAlme
||  ||. .|  || .|..|    |      .||||||.  |  | | .||||| .  .  ||||..||||   |||||   |  |.| | |||| .   
nkaknryanivtydhsrvvleklsnd..phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkk.chqywpds...

EEKFGPFIVTLTNVANHPSFTIRSLnVIIPDGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQ
  |.  . ||| .      . ||.. |.   |  . . . |||.| |||.|||.    .| |....     |   | ..||||||||||.|. ||  | |
tskycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

ADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
| ..  |||   |. .|..| .|||| .||||.| ||.
akkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1385-1672 1.3e-50 166.9 In-house 16-257 (392) alignment 
Range on Protein: 1385-1672
Range on HMM: 16-257/392.0
AKYSNKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERP
 ..|  | ...  |   .  | ||. .. |.  ||...|  || .|..|    .  . ...|.|||||... . . .||.||| . .| ||||...||..
nrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevidd..ipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenv

MHIVMLTDPKECIknkwceqywpralmeeekfgpfivtltnvanhpsftirslnviipdGSNDSHTLTQYHLTSWPDHGVPKP---LLSLHKQVMATWSP
  |.|.|. ||                                                  .| .| .|.|.| |||..|||    || . |.| | .  
ttiamvtklkegd..............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq

SEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFsETIIGGETEIPADKFATKLQELKE
   |...||||||||||  |.||  . .| .  .||.  .|  .|..|  |||| .|| |.. ||. | ..  .| ||  .|. .||.|. 
ythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl.edllwrntlipvvhftdhlqdlst
0043336 (Phosphotyrosine protein) phosphatases II 1675-1909 1.3e-50 167.8 In-house 15-277 (278) alignment 
Range on Protein: 1675-1909
Range on HMM: 15-277/278.0
SSTGCSGLQSQFELLSQVTPdlDDATEDNAGEDLAKNQGS--------------------NSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYK
  .....|. .|| | ....  |. .  .  |   ||. .                    ..| | |.  ||. ...||..| |...|  |||.|. ...
llnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

VSAIVMLCGEEDC----CYPYW-TGLSTHDDFVVEIANEIKSNGYIERMLNVES------RNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkIGGG
|. ||||.....     |..||  |  |..||.|.  .|.. ..|. | |.|.       | |.... ..|| .||   . ..|. . .|.....   .|
vttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsng

PVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYL
||.||||. |.|.|... . . ||| . || ||.... | .|. .||||.|..||  .|... .||
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 1709-1905 2.1e-50 166.7 Pfam-A 21-233 (235) alignment 
Range on Protein: 1709-1905
Range on HMM: 21-233/235.0
AKNQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYWT----GLSTHDDFVVEIA-NEI-KSNGYIERM
 ...|.. | | ..  ||..||.||..| |...|  |||.|....||..||||. .|.     | .||     .  |..|. ||.  .|  ....|. | 
kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrk

LNVE-------SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGA
|...       .| | ||..|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .||..||.
lelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgm

VTTLEQYTSIYDVI
|..||||  .|..|
vqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1709-1905 2.1e-50 166.7 In-house 21-233 (235) alignment 
Range on Protein: 1709-1905
Range on HMM: 21-233/235.0
AKNQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYWT----GLSTHDDFVVEIA-NEI-KSNGYIERM
 ...|.. | | ..  ||..||.||..| |...|  |||.|....||..||||. .|.     | .||     .  |..|. ||.  .|  ....|. | 
kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrk

LNVE-------SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGA
|...       .| | ||..|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||. |||.|. | .||..||.
lelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgm

VTTLEQYTSIYDVI
|..||||  .|..|
vqsleqYiflykai
DSPc_SM00195 1710-1909 4.3e-50 165.9 In-house 47-262 (263) alignment 
Range on Protein: 1710-1909
Range on HMM: 47-262/263.0
KNQ--GSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYWTGL----STHDDFVVEIANEIKSN-GYIERM
|..   ...| | ..  |.. ||..|..| |...| .|||.|... ||. ||||. ||..    |. ||       .|.... |.. ...| .  .| | 
keekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrt

LNVESRN------VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAV
|...  .      | |.|...||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..||..||.|
leltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmv

TTLEQYTSIYDVIDMYL
.|||||. ||..|  |.
qtleqYlfiyeaileyi
PTPc_SM00194 1710-1909 4.3e-50 165.9 In-house 47-262 (263) alignment 
Range on Protein: 1710-1909
Range on HMM: 47-262/263.0
KNQ--GSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYWTGL----STHDDFVVEIANEIKSN-GYIERM
|..   ...| | ..  |.. ||..|..| |...| .|||.|... ||. ||||. ||..    |. ||       .|.... |.. ...| .  .| | 
keekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrt

LNVESRN------VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAV
|...  .      | |.|...||. ||  ... ||...  | ......  ||.|||||. |.|.|......| |.....|  ||.|.. |..||..||.|
leltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmv

TTLEQYTSIYDVIDMYL
.|||||. ||..|  |.
qtleqYlfiyeaileyi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1711-1914 4.9e-49 162.1 In-house 71-285 (318) alignment 
Range on Protein: 1711-1914
Range on HMM: 71-285/318.0
NQGSnSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYWTG--LSTHDDFVVEIANEIKSNGYIERMLNV---
..||  | | ..  ||. |||.| ||.|. .| .|||.|. . . . ||||  ||.     .  || .    .... |||. .|.... |. | ..|   
eegs.DyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrt

---ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQY
   |||.| | ..|.||. ||  .. ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | .||
eeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqy

TSIYDVIDMYLQMNKA
. ||||.  .|.  ..
efiydvllealasgdt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1713-1913 1.2e-48 160.8 In-house 74-287 (319) alignment 
Range on Protein: 1713-1913
Range on HMM: 74-287/319.0
GSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGLS--THDDFVVEIANEIKSNGYIERMLN------
 .  | | ||  ||.....|| .|.|.|||  |||.|. ....| .|||..  .     .  ||.     .   ..|.. .| . ..|| | |.      
egsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkss

-VESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYT
 ||.|.| . | |.||...| .. ...|... .. . ..|   ||.|||||. | | | .. ... ||. | |||.|||.. . .|  ..  | . |||.
evetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYk

SIYDVIDMYLQMNK
 ||...  .... .
fiyealleaveagd
subfamily_PTPN14_pd Subfamily PTPN14 1405-1646 1.7e-48 160.1 In-house 40-292 (300) alignment 
Range on Protein: 1405-1646
Range on HMM: 40-292/300.0
PCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLymcEREYINASYIDGYSSS--NKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwC
 ....  .||.  |||...  |.|||. |.|. .    . .||||| |    ..   ..|..|||. .|. |||...|..    |||||. .|  |.| .
llstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek.s

EQYWPRA--LMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDgSNDSHTLTQYHLTSWPDHGVPK---PLLSL-------HKQVMATWS--PSEGPILV
 .|.|.     .. .|| | ||   . . .|.. ..|..     |..  |.     | |||||||.   . ||         ...  . .   |. |.||
fkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlv

HCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
||||||||||  |  |. ..  . . ..||  ...|||.||| .|||| || |.....
hCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl
0041856 (Phosphotyrosine protein) phosphatases II 1414-1649 3.5e-48 158.9 In-house 1-170 (182) alignment 
Range on Protein: 1414-1649
Range on HMM: 1-170/182.0
NKYLNRFQQITVYDDNRiiltpnpnlymcEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTdpkeciknkwCEQYWPralmee
|. .||.. |  || .|               ||||....|.  ...|||||||. .|.|||.|......  .||.||          .|.|||      
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..........eelywp......

ekfgpfivtltnvanhpsftirslnviipdgSNDSHTLTQYHLTSWPDHGVPKpLLSLHKQVMATWSpSEGPILVHCSAGVGRTGTFIAIDIALEQadre
                               ..  .. .||. ..|||||||  | .|.. . . .. ..||.|||||||||||||..|... ...    
...............................ellerlgiqylylpwpDhgvpd.ldelldfieevle.eggpvlVHCsaGvgRtgtlvaaylmkkl....

GvVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFSE
| |..  .|. .|..|..||.|..||.||..|.. .
g.vsleeavklvrsrRpgmvitpnqyfflqlallel
0040439 (Phosphotyrosine protein) phosphatases II 1711-1909 4.3e-48 159.5 In-house 35-246 (249) alignment 
Range on Protein: 1711-1909
Range on HMM: 35-246/249.0
NQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYW--TGLSTHDDFVVEIANEIKSNGYIERMLNVE--
.   ..| | |.  ||. |..||..| |...|  |||.|. ......||||. .. .    |..||   |  ...||.|.  .......|. |.| ..  
glflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnl

----SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQ
    || ||..|.|||| .||   . ..|. |. | . ....  ||||.||||. |.|.|...   . ||| . |. ||.... | .|. .||||...||
ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeq

YTSIYDVIDMYL
|  .|... ..|
yrflyeallell
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1417-1647 7.2e-48 157.8 In-house 41-274 (287) alignment 
Range on Protein: 1417-1647
Range on HMM: 41-274/287.0
LNRFQQITVYDDNRIILTPNPNLymcEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRAlMEEEKF
 ||. ..  .||.|..|. ...|     .|||| |. .|   ..|||.|||.  |. ||||.....|   ....|   |  ..| | .|||       . 
knryadvlPiddtrvllsaegel...GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk.cykywPer.evPmrv

GPF-IVTLTNVANHPSFTIRSLNVIIPDGsNDSHTLTQYHLTSWPDHGVPKP-------LLSLHKQVMATWSPSE-GPILVHCSAGVGRTGTFIAIDIAL
| . .| |     .| ...|.| .|  .. .... . |..| ||||....          |. .... .. . || ||..||...|.||.|...|. . .
GGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

EQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
..    | ||.| .| |||..|  .||.  |. .| .|. 
srledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1714-1911 7.5e-48 157.9 In-house 36-244 (250) alignment 
Range on Protein: 1714-1911
Range on HMM: 36-244/250.0
SNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG---EEDCCYPYWT--GLSTHDDFVVEIANEIKSNGYIERMLNVE------
   | | ||  ||...||||..|.|...|  |||.|....|...||||     .|  .  ||   .  .. |  |.. .. .   |. | | .       
esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkad

SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIY
.| | ||. . ||  || .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | | |||||.| |..|| .|.||..|||| ..|
erivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvy

DVIDMYLQM
 .|  .|. 
eiilkalds
subfamily_PTPN1_pd Subfamily PTPN1 1402-1652 1.3e-47 157.0 In-house 20-274 (290) alignment 
Range on Protein: 1402-1652
Range on HMM: 20-274/290.0
NDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlymcerEYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKw
.| |...  ..||. |||.. .. ||  ||.|  . |      .||||| ..      ..| ||||..|| . ||...|...   .|||    |  ..| 
sdfptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik.

CEQYWPRALM-EEEKFG--PFIVTLTNVANHPSFTIRSLNVIiPDGSNDSHTLTQYHLTSWPDHGVPKP---LLSLHKQVMA--TWSPSEGPILVHCSAG
| ||||.    .| ..    . |.| .  ..  .|.| |..     ..........| |.||| |||.    .|..  .|    . |.  || ..|||||
caqywPqgeeekellledtklkvkliseerksyytvrllele.nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VGRTGTFIAIDIALEQADREGV---VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFSET-II
.||.|||. .|  | . ....    |||   .  ||..|. ..|| ||  | . |.   . .|
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi
subfamily_PTPRN_pd Subfamily PTPRN 1388-1649 7.6e-47 154.4 In-house 28-291 (297) alignment 
Range on Protein: 1388-1649
Range on HMM: 28-291/297.0
SNKFEDQ--YLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYID-GYSSSNKFIATQGPMVNTLADFWRLIWQERP
 ...| .   |  |  ... ..|. ...|   || ...  ||..|. |. . .    . .||||| |      .  .||||||. .|.||||...|..  
kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeas..aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

MHIVMLTDPKECiKNKWCEQYWPRAlmEEEKFGPFIVTLTN-VANHPSFTIRSLNVIIPDgSNDSHTLTQYHLTSWPDHGVP---KPLLSLHKQVMATWS
. ||.||  .|    | |..|||     .| .. . | |         . .||. .   . .... |.||.|  |||..|||   |.|| . ..|  .. 
vvivnltrleee.gvkqckrywpde..Gsevyhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvnksyr

PSEGPILVHCSAGVGRTGTFIAIDIALEQADRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFSE
    ||.||||.|.||||..|.||. |..  .    .|||  .. ||.|| ..|.| ||. |   ||  |
GrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Ptp69D_pd Subfamily Ptp69D 1714-1917 2.4e-45 150.0 In-house 75-294 (307) alignment 
Range on Protein: 1714-1917
Range on HMM: 75-294/307.0
SNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYWT--GLSTHDDFVVEIANEIKSNGYIERMLNVE-----
. .| | ||  ||..|| ||.|| |.|.|. |||.|| . .|  ||||  ...     |  ||.      ..| .|....| | . ||.| |.|      
dsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkee

------SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLE
      ||.|.| . | |.   | . .|..|..|. | . ...   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||
sgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsle

QYTSIYDVIDMYLQMNKADDD
||. .|  .  | .. ..| |
qYvflyralldyssygdtded
subfamily_PTPRA_pd Subfamily PTPRA 1714-1911 1.9e-44 146.9 In-house 85-297 (330) alignment 
Range on Protein: 1714-1911
Range on HMM: 85-297/330.0
SNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCCYPYW--TGLSTHDDFVVEIANEIKSNGYIERMLNVE-----
.  | | ||  ||..|. || || | |.|  |||.|| ..| ..||||      .|. |. ||   || |. .  ||. .|  .. |  | . |.     
esdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpda

-----SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQ
     || | |.  | ||. ||  ||. .|...  | . .|. .| |.|||||  | |.| .. ..  ||. |||..||||.. | .|. .|  | |.||
trekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeq

YTSIYDVIDMYLQM
|. || |.  |   
yefiykvlleyyly
0042113 (Phosphotyrosine protein) phosphatases II 1714-1909 2.2e-44 147.1 In-house 36-243 (245) alignment 
Range on Protein: 1714-1909
Range on HMM: 36-243/245.0
SNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYW--TGLSTHDDFVVEIANEIKSNGYIERMLNVE-----
 ..| | |.  ||. .. ||..| |...|  |||.|. ......||||. ||.     |..||   .  |..||.|.  .| . ..|. | |.|.     
dsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgdd

-SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSI
 ||.|.... ..|| .||   ....|.... | . ... ..|||.||||. |.|.|... . . ||| ..|. |..... | .|. .||||.|..||  .
esrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl

YDVIDMYL
|... ..|
yeallell
0036282 (Phosphotyrosine protein) phosphatases II 1445-1644 6e-43 141.9 In-house 3-164 (174) alignment 
Range on Protein: 1445-1644
Range on HMM: 3-164/174.0
EYINASYIDGYSSSNKFIATQGPMVntladFWRLIWQERPMHIVMLTDPKEcIKNKWCEQYWPRalmeeekfgpfivtltnvanhpsftirslnviipDG
 |||||..|..  ....||.|||.      ||.......  ..|||...||  .. .| .|||.                                  . 
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleeke.lglykcinywpe..................................lr

SNDSHTLTQYHLTSWPDHGVPKPLLsLHK---QVMATWS-PSEGPILVHCSAGVGRTGTFIAIDIALEQADrEGVVDIAGIVNRLRQQRMKMVQTLDQYV
.  ...  ||. . |||||||     |..   .|    | ...||.|||||||||||||..|... | .   |..||.  .| .||.||..|||| .|| 
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FLHD
||..
flyy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1403-1646 7.4e-43 141.5 In-house 22-255 (267) alignment 
Range on Protein: 1403-1646
Range on HMM: 22-255/267.0
DRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNpnlymcEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDpkECIKNkwC
   ..  .. .|.  ||...   |||.|.||  .      |.|||||||..||   |.||.||.|. || .||. .| ...   ||.||     . |   
sstisqsiaeknqernrlddnlpyddtrvilrtk......eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk..vftdn..i

EQYWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSndSHTLTQYHLTSWPDHGVPKPLLSLHKQVMATWSP--SEGPILVHCSAGVGRTGTF
 ..||  . . .|.  . |  .   .   . | .|.. . . |  .| .| |.   |      || |     ..|       . |..|.||.||||.|||
rlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknes..ahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtf

IAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
. ||  ||.| .|||.||   . ..|.||. .|.|...|...|. .
lvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
0045098 (Phosphotyrosine protein) phosphatases II 1716-1912 9.5e-43 141.9 In-house 52-275 (278) alignment 
Range on Protein: 1716-1912
Range on HMM: 52-275/278.0
SYTNPSFTAGYhdKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYWT--GLSTHDDFVVEIANEIKSNGYIERMLNVES------
 | | |.  ||  .|.||..| |...|. |||.|. ......||||.....     |..||   |  |..||.|.. .|   . |. |.|.|.       
dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltvere

----RNVLQLQVTDWPQDGVVREP--RTVLQVIDDVIHRQQK------------IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVR
    |.| .|. . ||  ||  .|  . .|.... . .....             .||||.||||  |.|.|... . . ||..  ||.||.... | .|
dlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelr

KSKPG-AVTTLEQYTSIYDVIDMYLQMN
. .|| ||..||||  .|... ..|...
sqRpglavqnleqyrflyefllelllrg
0043147 (Phosphotyrosine protein) phosphatases II 1444-1643 1.4e-42 140.7 In-house 5-154 (172) alignment 
Range on Protein: 1444-1643
Range on HMM: 5-154/172.0
REYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPkeciknkwceqywpralmeeekfgpfivtltnvanhpsftirslnviIPD
. ||||||.|.|   ..|||||||. ||||||||.....   |||.||.                                                  |
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................lyd

GSNDSHTLTQYHLTSWPDHGVPkPLLSLHKQVMATWS----PSEGPILVHCSAGVGRTGTFIAIDIALeqadreG-VvDIAGIVNRLRQQRMKMVQTLDQ
... ...  ||. ..||||||| .|  | . .    .     ..||.|||||||||||||..|... |        . ..  .|. .|..|...||. .|
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsq

YVFLH
| ||.
yrfly
subfamily_PTPRK_pd Subfamily PTPRK 1712-1905 4.7e-42 138.9 In-house 68-273 (314) alignment 
Range on Protein: 1712-1905
Range on HMM: 68-273/314.0
QGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG-EED---CCYPYWTGL-STHDDFVVEIANEIKSNGYIERMLNVES---
. |. | | ... .|.  .|||..| |...| .|||... |.. ..||||    |     |. ||    ....|. ||. .    . .. |...||    
dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklar

-----RNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQY
     | | |.| . ||. .|  . ...|...  | . |.. . |..|||||    |.|... ..| |.  . |||||||.. |..|..|.  | | |||
gqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqy

TSIYDVI
. |||||
kfiydvi
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1413-1647 3.7e-41 135.7 In-house 53-280 (290) alignment 
Range on Protein: 1413-1647
Range on HMM: 53-280/290.0
ENK--YLNRFQQITVYDDNRIILTPNpnlymCEREYINASYIDGYSssNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRAL
.|     ||.....  |  |.||         . .|. | |..|      || |||.. .|  |.||.. ||.   |||| .  |  | | ||||.|   
kntefkknrykdvvcndktrvilkdG.....ydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkak.ceqyypeke

MEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPKPLLSLHKQVMATwSPSEGPILVHCSAGVGRTGTFIAIDIALEQA
 |   || . |. ..  .. . .|. .  .    |  .| |  ... ||||. |..  |.| . . .      ||. ||||||.||||||.||...|.  
GevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril.rkasGpvvvhcsaGiGrtGtfvaievglqil

DREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
     .|....|  ||. |.. ||   ||. | ....
ldGkeldlldlvralrnsrlnsvqvdiqylalveill
0037934 (Phosphotyrosine protein) phosphatases II 1712-1908 3.6e-40 133.4 In-house 30-241 (243) alignment 
Range on Protein: 1712-1908
Range on HMM: 30-241/243.0
QGsNSYTNPSFTAGYhDKkaFIIAQSPMENTARD----FWKMIVDYKVSAIVMLCGEE----DCCYPYWTGLSTHDDFVVEIANEIKSNGYIERMLNVES
.| ..| | ... .. ..  .|. | |...|  |    ||.|. ......||||. ..      |..|| |  |..||.|.. .|   ..|. |.| .| 
eg.sdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllen

-------RNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGvVDVFQVTKAVRKSKP
       |.| ... . ||  ||  .|  .|. .|.|.  ...        .||||.||||  |.|.|...   . |...   | ||.... | .|. .|
ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRp

G-AVTTLEQYTSIYDVIDMY
| ||.|..||  .|... ..
gkavqtpsqyrflyeallel
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1713-1905 3.9e-40 132.5 In-house 55-262 (283) alignment 
Range on Protein: 1713-1905
Range on HMM: 55-262/283.0
GSNSYTNPSFTA---GYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC----GEEDCCYPYWT--GLSTHDDFVVEIANEIKSNGYIERMLNVES
 |..| | .|      |...| .||||||...| .|||||. | |..|||||     ...  |  ||   |   . .| | . .|  || .| . | .  
esrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrv

R-----NVL--QLQVTDWpqdgVVREPRTVLQV---IDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVT
      ..|    || ||    .  .. ...     .. ||  |..   ||.||||| .. |..|....|  ... ..| |||||.| | .|. ...|| 
nssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavq

TLEQYTSIYDVI
||.||  .....
tldqyklvhelv
0049260 (Phosphotyrosine protein) phosphatases II 1451-1644 1.7e-39 130.3 In-house 1-144 (152) alignment 
Range on Protein: 1451-1644
Range on HMM: 1-144/152.0
YIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKEcIKNKWCEQYWpralmeeekfgpfivtltnvanhpsftirslnviipdgsndsht
.||||  ...|||||||. ||||||||....    .|||||.. | ..  .||||.                                            
fidgyampfefiatqgpgpntladfwrmlkelgittivmltelle.lgklkceqyi............................................

ltQYHLTSWPDHGVPKPLLSLHKQVMAT---WSPSEGPILVHCSAGVGRTGTFIAIDIALeqadreGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
  ||. . |||||||.    |   . .    .  ..||.|||||||||||||..|... |        |..  .|...|..|...|.. .|. ||..
..qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0049772 (Phosphotyrosine protein) phosphatases II 1403-1646 1.9e-39 131.6 In-house 35-276 (314) alignment 
Range on Protein: 1403-1646
Range on HMM: 35-276/314.0
DRPCTVGYTDENKYLNRFQQITVYDdNRIILtPNPNLYMCEreYINASYIDGYsssNKFIATQGPMVNTLADF----------WRLI--WQERPMHIVM-
.  ..|..  .|.  ||...|  .| || || |. . . .   ||||||.||.   .||||||||. .|. ||          ||..  .. ..  ||| 
eltilvadlflnrdknryldilpad.nrvil.pglpvsgsd..yinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------LTDPKECIkNKWCEQYWPRALmeeekfgpfivtlT-------NvanhpsftirslnviipdgsndSHTLTQYHLTSWPDH
                    |... .   | .......                .                              ...  .|. . .||.
rdevladelsrLdaAlgKtpllildgng.neptaadlellk.............eelydpelf......................erlgikylripvpDg

GVP--KPLLSLHKQVMATwsPSEGPILVHCSAGVGRTGTFIAIDIALEQAdreGVvDIAGIVNRLRQQRM-----KMVQTLDQYVFLHDAV
..|  . .... . . .   . .||.||||.||.||||||..... . .    || ... .....|..|.      ....|.||.| ..|.
saplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefileal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1711-1913 2.3e-39 130.3 In-house 75-288 (297) alignment 
Range on Protein: 1711-1913
Range on HMM: 75-288/297.0
NQGSNSYTNPSFTAGYHDkkAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE---DCCYPYWT--GLSTHDDFVVEIANEIKSNGYIERMLNVESRN
.. .  | | ||  |..    .|  | ||..|  |||.|..|..||.||||  ..   . |  ||.  | .|  | .|..    . .|.|.| |.|.  .
ddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgk

------VLQLQVTDWPQDGVVR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQ
      | | | ..||.. | |  . ...|..|..| .  ..   ||..|||.  | | ||....   . . | |  ||.|.. | .|...|  | | ||
akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeq

YTSIYDVIDMYLQMNK
|. .| ..  .|  ..
ykfvyvavleallsed
0046846 (Phosphotyrosine protein) phosphatases II 1445-1646 3.1e-39 129.9 In-house 13-169 (176) alignment 
Range on Protein: 1445-1646
Range on HMM: 13-169/176.0
EYINASYIDGYsssnKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRalmeEEKFGPfivtltnvanhpsftirslnviipdg
 ||||..|.|.    ..||||||...|||||........  ..|.||...|  . | | .|||.    .||.|                           
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlk.cpnywpe....leklgi..........................

sndshtltQYHLTSWPDHGVPKPlLS--LHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEqadrEGVVDIAGIVNRLRQQRM-KMVQTLDQYVF
        ||. . |||||||          . . ..  . ||.|||||||.|||||..|...       |  ...  .. ..|.||. ..||| .|| |
........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrf

LHDAV
|....
lyefe
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1709-1906 9.7e-39 128.1 In-house 71-276 (315) alignment 
Range on Protein: 1709-1906
Range on HMM: 71-276/315.0
AKNQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC----GEEDCCYPYWTGL-STHDDFVVEIANEIKSNGYIERMLNVES
 .|.    | | .|  ||  |. .| ||.|  .. .|||... ..... ||||     ||.  .  ||     ..  . |   .| . . |  | | | .
lendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvf

----RNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYT
    |.|.||..| ||. || .   .....|  |   ...   |..|||||. | |.| .....  |.| .|| ..||... . ||. . ..| ..||| 
gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyq

SIYDVID
 |||.. 
fiydall
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1389-1647 8.3e-38 125.1 In-house 16-274 (307) alignment 
Range on Protein: 1389-1647
Range on HMM: 16-274/307.0
NKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPnlymCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIV
... |..  |   .    ||   . |   ||.|.. . | .||... .        .|| | |.      .|||..|||. ||  .|| .. ||.   ..
qalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdg....lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvi

MLTDPKECIKNKwCEQYWPRALMEEEKFG--PFIVTLTNVANH-PSFTIRSLNV--IIPDGSNDSHTLTQYHLTSWPDHGVPKPLLSLHKQVMATWSpSE
|| .  |  | | ||||||    ..  ||  |  ....|.  .  .     .||  .  | ...| |....  . |||.|||.  |.    . |.    .
mlckvielakik.ceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry.dt

GPILVHCSAGVGRTGTFIAIDIALEQ-ADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
 |..|||||||||.|| .|| .  ..  . .   |.  .|. ||.||   .||  ||..||  ..
npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvll
subfamily_PTPN12_pd Subfamily PTPN12 1710-1910 1.1e-37 124.6 In-house 63-278 (290) alignment 
Range on Protein: 1710-1910
Range on HMM: 63-278/290.0
KNQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE----DCCYPYWTGLS----THDDFVVEIANE-IKSNGYIERMLN
...  ..| | .|  | ..|...| ||.|. .|  |||.|| ...|. .||.| |       |  ||.       ....| |.  .|   ..... |.|.
eeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLk

V----ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRKSKPGAVT
|    |||.| |.. |.||  || . . ..|..|..| ..|.     |.|||||  | | |. ... .  |. ||| .   .|||..   .|| .. .| 
veaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvq

TLEQYTSIYDVIDMYLQ
| |||. .|  .  ..|
tkeqyelvykavaelvq
subfamily_PTPRG_pd Subfamily PTPRG 1708-1909 3.8e-37 122.7 In-house 69-287 (563) alignment 
Range on Protein: 1708-1909
Range on HMM: 69-287/563.0
LAKNQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCCYPYW--TGLSTHDDFVVEIANEIKSNGYIERMLNV
|. ....  | | ..  ||. .||||..| |...|. |||.|| . .|. |||.      .   |  ||   .  | . . | . .| .   | .| | .
lpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlvi

ES------------RNVLQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKP
.             ..| | . |.||. ||   .  ||. .     . .|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..
knlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRn

GAVTTLEQYTSIYDVIDMYL
  |.| |||. ..|..   .
flvqteEqYiflhdalleai
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1711-1911 1.8e-36 120.6 In-house 68-279 (315) alignment 
Range on Protein: 1711-1911
Range on HMM: 68-279/315.0
NQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG--EEDC--CYPYWTG----LSTHDDFVVEIANEIKSNGYIERMLN--
..  . | | |.  ...| ||.| .| | . .  |||.|....||..|||.    |.|   |  ||      .     . ||. .     . . | |   
dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtr

--VESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQY
   |||.| | | |.||. || ..  ..|..| .|    ..    ...||||  | |.|| .|.   ..| | . .||||.. | .|. .|  | | |.|
kseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeey

TSIYDVIDMYLQM
. |||..  .|. 
afiydavledllw
subfamily_CG7180_pd Subfamily CG7180 1712-1912 1.9e-36 120.2 In-house 68-293 (296) alignment 
Range on Protein: 1712-1912
Range on HMM: 68-293/296.0
QGSNsYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC---CYPYWTGL--STHDDFVVEIANEIKSNGY------IERM--
. |. | | ..  ..  ||..|. . |...|  .||... | ..||.|.|. . |    .  ||       . ...||| .| .          . ..  
eksd.YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkiv

--------LNVESRNVLQLQVTDWPQ-DGVVREPRTVLQVIDDVIHRQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVR
         ..| | |...|.| |.  | |     ......  |   ..|.      |||||..|| .||||||... . ||. . |. ||||.  | .|
alteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlr

KSKPGAVTTLEQYTSIYDVIDMYLQMN
.|.|. | . |.|  ||||.  .. .|
rsRpqLvenveeYkyiYdvlleavlcn
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1415-1646 2.6e-36 119.9 In-house 49-283 (305) alignment 
Range on Protein: 1415-1646
Range on HMM: 49-283/305.0
KYLNRFQQITVYDDNRIILTPNpnlymCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPR---ALM
.  ||....   |.||. | .         ||| | |.   . ...|| || |. .| |||| . .|..   | || . .|   .| | .|..      .
agknrykdvgcldnnrvklegp.....wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakk.cleyfaskdkdvl

EEEKFGPFIVTLTNVANHPS------FTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPKPLLSLHKqVMATWSPSEGPILVHCSAGVGRTGTFIAIDI
| |. |  |.   . ..  .       ...   ..|    ....  |.||   ||| |||   |.. . ...   || ||| ||||||.||||. . .. 
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlaile.llekarpskgpivvhcsagigrtgsvvmley

ALEQADREGV-VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
 |.|     .  |   |....|.|| . .|| .||.|.|. .
ildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1715-1904 3.3e-36 120.2 In-house 89-286 (319) alignment 
Range on Protein: 1715-1904
Range on HMM: 89-286/319.0
NSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCgeEDCCYPYWT--GLSTHDDFVVEIANEIKSNGYIERMLNVES-------RN
  | | || .||  |. .| || |..||  |||.|| .|..|.||.|   .| |  ||   .  ... | |..    ... |. | ...         |.
sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirk

VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDV
. |     ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
itqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1713-1911 3.8e-36 119.6 In-house 55-270 (274) alignment 
Range on Protein: 1713-1911
Range on HMM: 55-270/274.0
GSNSYTNPSFTAGYHD-KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG--EE--DCCYPYWTGLS------THDDFVVEIANEIKSNGYIERMLNV
   || |  .  ||.  .||.. .| |. ||  |||.||   .|. ||||    |.  . |  |.          ...|. ... . .. |.|  | | .
edssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvl

E----SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTL
.    .|.|     ||||   . ....|.|.....| . ...     .|||||||  . | |.. ..||.. | ..|.||||....  .|  . | | | 
kylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts

EQYTSIYDVIDMYLQM
|||  |. .. .||. 
eqyelihralclylkr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1715-1904 4.3e-36 119.9 In-house 53-250 (284) alignment 
Range on Protein: 1715-1904
Range on HMM: 53-250/284.0
NSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCgeEDCCYPYWT--GLSTHDDFVVEIANEIKSNGYIERMLNVES-------RN
  | | || .||  |. .| .| |..||  |||.|| .|..|.||.|   .| |  ||   .  ... | |..    .|. |. | ...         |.
sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirk

VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDV
. |     ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | |  |||... . .|. ..  |  | ||  ||  
irqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1711-1906 4.9e-36 119.3 In-house 71-276 (288) alignment 
Range on Protein: 1711-1906
Range on HMM: 71-276/288.0
NQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTGLST---HDDFVVEIANEIKSNGYIERMLNVE-
.. .. | | |. .|.. ||..| .|.|. .|  |||... ..|.| |||| .    ..  |  ||    .   . .. |.. .. . . ...| | .| 
eeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllek

---SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYT
    ... |.| . ||..|| .  . .|.... |   .|.   ||..||||. | |.|.. ..   ... ..| ..||. . . .||...  | ||.|| 
kkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYe

SIYDVID
 ||.|. 
fiyevll
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1405-1653 9.8e-36 118.2 In-house 26-272 (285) alignment 
Range on Protein: 1405-1653
Range on HMM: 26-272/285.0
PCTVGYTDENKYLNRFQQITVYDDNRIILTpnpNlymCEREYINASYIDGYS-SSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCE
 ||    . |  |||. .. . .. |..|    |    .|.|| ||..       . .|.||||. .||.|||..|.||.  ...||    |   .| | 
nctytayeanpdlnryadvrcieetrvvlk...n...hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvek.ca

QYWPRALMEEEKFGPFIVTLTNVANHP-SFT-IRSLNVII-PDGSNDSHTLTQYHLTSWPDHGVP---KPLLSLHKQVMAtWSPSEGPILVHCSAGVGRT
 |.|  | |  ||| . .|||.. .   . | . .| ||   | |..   . . ..  |||.  |   .|.. |.| |     | | || ||||||||||
lyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrt

GTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHdAVFSETIIG
 ||. || |  .   .  ...  ||  .|  |.. ||.  |..||.  |. | .||
atfvgidyatirimenpniemldivremramrfqavqshmqflfly.vvlmeyfig
subfamily_PTPRB_pd Subfamily PTPRB 1710-1913 1.6e-35 117.6 In-house 74-289 (293) alignment 
Range on Protein: 1710-1913
Range on HMM: 74-289/293.0
KNQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC--GE--EDCCYPYWTGL---STHDDFVVEIANEIKSNGYIERMLNVE
|.. .. | | ..  ||. .. || .| |. .|  |||.|. . |.|.||||    |     |  ||       .. |  |.. .| . . .. | |..|
kdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkie

----SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQ
    .|.| |.. | ||. ||  ...|.|. .  | ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .|
kekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq

YTSIYDVIDMYLQMNK
|  |....  .|. ..
Yifihqcvldllrkke
subfamily_PTPN6_pd Subfamily PTPN6 1718-1913 4e-35 116.3 In-house 84-301 (306) alignment 
Range on Protein: 1718-1913
Range on HMM: 84-301/306.0
TNPSFTA--GYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGLSTHDDF---VVEIANEIKSNGYIERMLNVE------
 | ..        .|..| .|  .|.|  |||.|... .   |||.  | .     |..||   ......    |.  .| . . || | |.|.      
inanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkk

-SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRKSKPGAVTTL
 .|.| |.. ..||. || ..| .||. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | | 
eerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqte

EQYTSIYDVIDMYLQMNK
.||  .| .| .|.. .|
qqykfvykaikkyietkk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1711-1910 4.6e-35 115.7 In-house 67-277 (515) alignment 
Range on Protein: 1711-1910
Range on HMM: 67-277/515.0
NQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE----DCCYPYWTGLS----THDDFVVEIANEIKSNGYIERMLNV-
..  . | | |.  ...  ||.| .| | . .  |||.......|..|.|.   .      |  ||            . ||.       | | | |.| 
dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl

---ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQY
   .|| | | . |.||. || .. ...|..| .|   ....   |...|||  | | ||..|.   . . |   .||||.. . .|. .|  | | |||
kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqy

TSIYDVIDMYLQ
. ||...  .| 
afiygavledll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1711-1911 5.9e-35 115.7 In-house 65-278 (281) alignment 
Range on Protein: 1711-1911
Range on HMM: 65-278/281.0
NQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGLS---THDDFVVEIANEIKSNGYIERMLNV--
.. .. | | .| .||...|..|..|.|. ..  .||.|....|||||||.  | .     |. ||   .   .  |..|.  .| ... |||| ...  
enkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkler

---ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRKSKPGAVTTLEQ
   |.|.| ||. | ||. ||  ... .|.  ..| . ..|    |.|.|||  | |.|.| ..   .....||   .|| .| . .||..   | |. |
esgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvq

YTSIYDVIDMYLQM
|. .| ..  .|. 
yefvykavldaldk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1713-1912 2.2e-34 113.7 In-house 46-267 (270) alignment 
Range on Protein: 1713-1912
Range on HMM: 46-267/270.0
GSNSYTNPSFTAGYHD-KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTGLSTH----DDFVVEIA--NEIKSNGYIERMLNV
    | |  . .|... ||..| |..|...| ..||.||.. ||.||||. |      . |  ||.  . .     |  ....  .| |..||| . |..
sataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrl

E----SRNVLQLQVTDWPQDGVVREPR------TVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPG
|    .|...  . ..||..||.||.        .|... .|  .....  ..|..||||. | |.|.   . |...  . .. ||| .. ...|| .. 
eekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRma

AVTTLEQYTSIYDVIDMYLQMN
 | . |||. .| .. .| .. 
lvqhpeqyeflykavveyaerr
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1710-1909 5e-34 112.9 In-house 71-288 (325) alignment 
Range on Protein: 1710-1909
Range on HMM: 71-288/325.0
KNQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVML---CGEEDCCYPYWTGL----STHDDFVVEIANEIKSNGYIERMLNV-
|...|  | | |.   . .|. |. ||.|. .|  |.|....|.. | .|.|    ...| |  ||        |   . |..    .   |. |.|.| 
kddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvk

-----ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGA
     |.| | |.|.  |.. || . | |.. ... | . ....     . .|..||||. | |.||. |.   |..   |  ||.|.. | .|| .|  
qvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsm

VTTLEQYTSIYDVIDMYL
| | .||. ||. .  ..
vetvdqyiliyealveay
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1444-1641 5.3e-34 112.3 In-house 75-272 (301) alignment 
Range on Protein: 1444-1641
Range on HMM: 75-272/301.0
REYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALMEEEKFGPFIVTLTNVAN--HPSFTIRSLNVII
|  | | .|.    ...|||||||. ||  ||| .. |    .||||.   |  ..| ||.| |    |. . | | ....|     . . . |.|.|  
rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleek.ceeylpvkisekldigrfkikiknkelilnkkiskrtleved

PDGSNDSHTLTQYHLTSWPDHGVPKPLLSLHkQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVF
  |  ...|.| |  ..|.|.||||    |. ..|     || ||.||||||.||. .||. ..   . . .  ....  ...||..| . |||  |  .
stgkfatrtvthyqysewtdrgvPkshaelf.dlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1412-1646 6e-34 112.1 In-house 53-285 (305) alignment 
Range on Protein: 1412-1646
Range on HMM: 53-285/305.0
DENKYLNRFQQITVYDDNRIILTpNPNlyMCerEYINASYIDGYS-SSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRAL
| ..  ||.|.. . | . . |  .|.   .  .|| | |.       ..||..|||. .|. .|| .. |..  .||||    |  | | | |||| | 
diaitknryqdvpcqdqsavkld.kps..ps..dyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklk.caqywpaaq

MEEEKFGPFIVTlTNV------ANHPSFTIRSLNVIIPDGsnDSHTLTQYHLTSWPDHGVPKPLLSLHkQVMATWSPSEGPILVHCSAGVGRTGTFIAID
 |  ..   ||   ||         .   |  ||.    .  .. .. . . | ||| |||   |.   .....   |. ||.||||||.||||| .||.
geklelksgivv.envsgskpmerdaeiqitllnltysgd..qkmsvrhlqwtewpdrgvppckltsl.ellsairgskvpivvhcsagigrtgtivaie

IALEQ-ADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
  ||. |.   .  .  .|. ||.||   .|.  ||.|.|  .
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvm
subfamily_egg_pd Subfamily egg 1401-1661 6.5e-34 112.0 In-house 27-283 (307) alignment 
Range on Protein: 1401-1661
Range on HMM: 27-283/307.0
GNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYMCerEYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECiknK
 .. . |  ..|.|.   | ...   |  |. |  .   |.   ..| | ...|    |.|| .| |. ||  ||||...||.  .|||||  ||    .
vdeislttaasdnnlekarskrvhckdssrvklelrrGqyld..dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes...e

WCEQYWPRALMEEEKF--GPFIVTLTNVA--NHPSFTIRSLNVIIPDgsN--DSHTLTQYHLTSWPDhgVPKPLLSLHKQVMAtwspsEGPILVHCSAGV
 || |||.|  .  ..  | . ..  .|     | |..  |... .|  .        |. .    |  |  ||  | |   .       |..|..  ||
rceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdvnnssd..vysplrvlrklrnl.....skpvvvqdilGv

GRTGTFIAIDIALEQADREGVV--DIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF--SETIIGGETEIPAD
 ...|..||.||| .  |  ..   .   |  ||..|   |..  .|.|..  |      .||   |.  |
skaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvd
0051082 (Phosphotyrosine protein) phosphatases II 1445-1645 1.2e-33 111.2 In-house 4-148 (151) alignment 
Range on Protein: 1445-1645
Range on HMM: 4-148/151.0
EYINASYIDGYsssnkFIATQGPmvntLADFWRLIWQERPMHIVMLTDPKECIknkWCEQYWPRALmeeekfgpfivtltnvanhpsftirslnviipdg
 |||.||..|.     .....||    ||||..|....   .||.|....|     .| .|.|..                                   
dyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg...ycpeylpelg..................................

sndsHTLTQYHLTSWPDHGVPKPLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQadregvVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
    ..........|||.|.|  . .. . . .  ....||.|||||||.|||||..|... |..      |... ... .|..|. .||. .|..|.. 
....ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

A
|
a
PTPc_DSPc_SM00012 1551-1647 2.2e-33 110.0 In-house 2-104 (105) alignment 
Range on Protein: 1551-1647
Range on HMM: 2-104/105.0
LTQYHLTSWPDHGVP---KPLLSLHKQVMATWSPSE--GPILVHCSAGVGRTGTFIAIDIALEQADRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
...|| |.|||||||   ...|.| ..|.   . ||  .|..|||||||||||||.|.||.|.| ..| . |||  ||..||.||..||||..||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVF
|. 
all
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1406-1645 2.7e-33 109.8 In-house 29-264 (281) alignment 
Range on Protein: 1406-1645
Range on HMM: 29-264/281.0
CTVGYTDENKYLNRFQQITVYDDNRIILTP-NPNLYmcEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQ
|||     |.  ||. .| . |  |. |    ||      .|| | ||        .| ||||  .| |||||.||||    |||| .  |  ..| | .
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnkn..stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrek.cae

YWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIpDGsnDSHTLTQYHLTSWPDHGVPKPLLSLHKQVMATWSPSEgPILVHCSAGVGRTGTFIAID
|.||      .|  . |.  . .   |.    ||.   .|  ... .|..    |||  ||.    . | .    . |  | ..||||||||.||..|..
yfprnahcclqfdklsvsyedstvnkslvttrlnlsy.eg..etrlithwlwkewpdwqvpessevmlkilrkirarst.ppvihcsagvgrsgtlmave

IALEQADRE-GVVDIAGIVNRLRQ-QRMKMVQTLDQYVFLHDA
|||.       . ||  || .||   |   ||||.||...   
ialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1416-1650 3.4e-32 106.6 In-house 45-271 (288) alignment 
Range on Protein: 1416-1650
Range on HMM: 45-271/288.0
YLNRFQQITVYDDNRIILTPNPNLYmcereyINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALMEEEK
  .|....   |  |. |. .|..|      |.|  .      ...| .| |.  |.  .|... ..   .||||..  |  |.|  ..|.|  | |. .
trdryenlprcditrvklsddpdfy......iaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkek.saeyfPsklGekar

FGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPKPLLSLHKqVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGV
.| .     .  .    ...   . |    ...  . . ||  |.|.|||.  ||  . ..      . ||.||.|||||||||.| | ||||..  .  
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplr.llevlkslqkPivvhssaGvGrtgtlililialeslrlddf

VDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFSET
. |  ....||..|.| .||  ||...|  |. | 
lgirsllaklreerfkaiqtemqylyvhrcvleel
0044763 (Phosphotyrosine protein) phosphatases II 1426-1644 6.9e-32 105.9 In-house 2-165 (178) alignment 
Range on Protein: 1426-1644
Range on HMM: 2-165/178.0
YDDNRIILTPNPNLYMceREYINASYIDGYsssnKFIATQGPmvntlADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALMeeekfgpfivtltn
.|..| .|.. ..| .   .|||||.|...     ......|     ||...|....   |||.||...|. ..| | .|||.                 
ldrtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflk.cdpywpeeag..............

vanhpsftirslnviipdgsndshtlTQYHLTSWPDHGVPK---PLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQadreGVvDIAGIV
                           ||. . .||||||     .| ... . .  ....||.||||||||||.||..|... ...    |. ..  ..
..........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeai

NRLRQQRMkMVQTLDQYVFLHD
...|..|. .|.. .|. .|..
elvrerRp.ivpnpgqlrqLye
subfamily_ptpA1_pd Subfamily ptpA1 1376-1611 1.1e-31 105.1 In-house 9-257 (418) alignment 
Range on Protein: 1376-1611
Range on HMM: 9-257/418.0
SINDLVNHIaKYSNKFEDQYlRLYTGNDRPC--TVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYsSSNKFIATQGPMVNTLA
|| .| ||| |   | .... ||   .  |   . |    |   ||. .|   .  |. |    .      .|||| ||||    ..||.||||. ||.|
siynlknhi.kcihkikeef.rlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqd..kegsdyinanyidga.ypkqfictqgplpntia

DFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALMEE---------EKFGPFIVTLTNVANHPSFTIRSLNVIIPDgSNDSHTLTQYHLTSWPDHGV
||||..|..|   ||||.   |  . | |..|||  .  |         | || . | | .| . |   | . |. .     ... .|||.   |||| .
dfwrmvwenrcriivmlsresencrik.cdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf.egetrditqyqyegwpdhni

PK---PLLSLHKQV------MATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQAD
|    |.  | . .      .   |  . ||.||||||||||||| .  | ... |
pdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkld
0041856 (Phosphotyrosine protein) phosphatases II 1715-1912 1.9e-31 104.5 In-house 19-174 (182) alignment 
Range on Protein: 1715-1912
Range on HMM: 19-174/182.0
NSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCgeedcCYPYWTglsthddfvveianeiksngyiermlNVESRNVLQLQVTDW
..| |... .|..  . ||..| |. .|  ||..|. ......||.|.     ...||                           . . |...|.. . |
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywp..........................ellerlgiqylylpw

PQDGVVRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQMN
| .||   ....|. |..|..      ||||.||||  |.|.|...   . ...    | |..... | ||. .||.|.|..||  ..... ..|. .
pDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllk
0051429 (Phosphotyrosine protein) phosphatases II 1715-1910 2.1e-31 105.0 In-house 4-226 (272) alignment 
Range on Protein: 1715-1910
Range on HMM: 4-226/272.0
NSYTNPSFTAGYHD---KKAFIIAQSPMENTARDFWKMiVDYKVSAIVMLCGEE----DCCYPYWTGLSTHDDFVVEIANEIKSNGYIERM---------
..| | ..  ||.    ..... .. |...||.|||..  ......||.|..||    . |..|| |.  .   ... . .  . |..  .         
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

------------LNVESRNVLQLQVTDWPQDGVVREPrtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD--------VF
             . |.| |..|. |||| .|| .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QVTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQ
.. . .|.  |||| | |||  .|...  .| 
eaveelraqrpgavqteeqylflyeallellr
subfamily_PTPN9_pd Subfamily PTPN9 1712-1908 2.2e-31 104.0 In-house 67-289 (297) alignment 
Range on Protein: 1712-1908
Range on HMM: 67-289/297.0
QGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG--E--EDCCYPYWT-GLST---HDDFVVEIANEIKSNGYIERMLNVE-
.    | | .|. ||. ||||| .| |...| .|||.|. . .|  |||     |     |  ||  .  .   . |. |.  .  ... | .|.|... 
deasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleikn

-----SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ------------KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVR
     ||.|   |.. ||  || ..  ..|.|.. | ..|             .. | |.|||||  . |.| .... | |.. . .|.|||... | .|
vkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllr

KSKPGAVTTLEQYTSIYDVIDMY
. .  .. | |||.  |  .  |
tqrafsiqtpeqyefcylavley
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1393-1646 4.8e-31 102.5 In-house 31-286 (310) alignment 
Range on Protein: 1393-1646
Range on HMM: 31-286/310.0
DQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYmceREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTD
 || .| . .|   |     .. . ||. .. . |. |. |. .   |    .|| | |.      . || .|||.  |. ||||.|.|||   |..|  
kqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksry...edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck

PKECIKNKwCEQYWPrALMEEEKFGPFIVTltNVAN-HPSFTIRSLNV-IIPDGSN---DSHTLT-----QYHLTSWPDHGVPKPLLSLHKQVMATwSPS
  |  . | |  ||| .|   | .|   ||  |...    | |  | | ..||      .   |        .   ||| |||        | . .    
vgeegrpk.cvgywp.slgvtetygcirvt..nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrlla.qvr

EGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
 || .||||||..|... .|........||   ||.  ..  |...|.. .||  ||....   
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
BolA BolA-like protein 1968-2043 9.5e-30 89.0 Pfam-A 1-76 (76) alignment 
Range on Protein: 1968-2043
Range on HMM: 1-76/76.0
KLNESMKPQYLKVINESYKHAVPKGSETHFNIIVVSEKFESMPLLQRHRLINSILEHELQTGVHALSIQARTVVQW
||.....|. |.|..||.|||.....|.||....|||.|| . ...||||....|..||..|.||||....|  .|
kleaalapeelevedeshkHaghaageshfkvvivseaFegksrvkRhrlVyalLkeelkegiHALslktytpeew
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1713-1908 1.1e-29 98.2 In-house 55-258 (267) alignment 
Range on Protein: 1713-1908
Range on HMM: 55-258/267.0
GSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC--GEED--CCYPYWTG-LSTHDDFVVEIANEIKSNGYIERMLNVESRNVL
  . | | |.  ||. |.|||. | |..||  ||...| |.||. ||.|   ....    .|   |    ..|..|| . | . | |    |... .|  
keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknes

QLQVTDW--PQDGVVREPRTVLQVIDDVIHR-QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDV
  .|| .   .  .  . .  |. .  .. . | . |. |.||.||| | ||| .  .   ||. | |||.|.|.  . .|. ..| | |.|.|  |...
ahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel

IDMY
.  |
laey
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1715-1905 1.6e-29 97.7 In-house 76-275 (439) alignment 
Range on Protein: 1715-1905
Range on HMM: 76-275/439.0
NSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCcYPYWTGLS--THDDFVVEIANEIKSNGYIERMLNV--------ESR
  | |  .  ||.|.| .| .| | ..|. |||..... |.. ||||.   .  | ||   .   . | .| .  .|.   |. | ..|          |
shyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlves.ykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdtteker

NVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDV
 |||.. . ||.  |  .   ||. .  .   ..|   ||||||||  | |.|   .. | ||| |.|  ||.  . | .|| .   | .| ||  ||. 
tvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiyna

I
.
v
subfamily_PTPN23_pd Subfamily PTPN23 1731-1905 2e-29 97.3 In-house 84-276 (288) alignment 
Range on Protein: 1731-1905
Range on HMM: 84-276/288.0
AFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCCYP----YWTG----LSTHDDFVVEIANEIKSNGYIERMLNVES------RNVLQLQVTDWPQ
 ||..|.|...|. |||.|... |.| ||||  .|.   |    ||        ...|. | . .. ... ..||.|..|       ..|  ||.| ||.
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpe

DGVVREPRTVLQVIDDVIH---RQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVI
 ||   | |.||..| | .    .|.    |.|||||  | |.||.. |   ...  | .|..|. || . .|. .   | . ||.   |...
lGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
0036282 (Phosphotyrosine protein) phosphatases II 1715-1903 3.7e-28 93.8 In-house 2-164 (174) alignment 
Range on Protein: 1715-1903
Range on HMM: 2-164/174.0
NSYTNPSFTAGYHDKKAFIIAQSPMEntardFWKMIVDYKVSAIVMLCGEED----CCYPYWTGlsthddfvveianeiksngyierMLNVESRNVLQLQ
..| | |.  ...  . .|. | |..     ||.|. .......|||. |.      |. ||                         . . ..|...|..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.......................lredlerlgiqyl

VTDWPQDGVVREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYD
 . || .||   .  .|.... | . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
ylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1458-1643 7.1e-28 92.1 In-house 4-197 (199) alignment 
Range on Protein: 1458-1643
Range on HMM: 4-197/199.0
SNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECiKNKWCEQYWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSND-SHTLTQYHL
  ..|||| |. .|.||||...|.    ||||. | .   |.     ||| .     |.| . ||   .. .| .|| .| .     .   .  ...| .
qrryiatqhplretmadfwqmvwetgsghivmvnddqkn.keadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHGVPKPLLSLH-----KQVMATWS-PSEGPILVHCSAGVGRTGTFIAIDIALEQA--DREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
||| ..  |.  | .      ..|   .    . |..|||| | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1459-1643 8.3e-28 91.9 In-house 4-196 (198) alignment 
Range on Protein: 1459-1643
Range on HMM: 4-196/198.0
NKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECiKNKWCEQYWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSND-SHTLTQYHLT
 ..|||| |. .||||||...|.    ||||. | .   |.     ||| .     |.| . ||   .. .| .|| .| .     .   .  ...| .|
rryiatqhplretladfwqmvwetgsghivmvnddqkn.keadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPKPLLSLH-----KQVMATWS-PSEGPILVHCSAGVGRTGTFIAIDIALEQA--DREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLH
|| ..  |.  | .      ..|   .    . |..|||| | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
0043147 (Phosphotyrosine protein) phosphatases II 1713-1903 9.2e-28 92.5 In-house 3-155 (172) alignment 
Range on Protein: 1713-1903
Range on HMM: 3-155/172.0
GSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEedccypywtglsthddfvveianeiksngyiERMLNVESRNVLQLQVT
... | | |.  .|.  . ||. | |. ||  |||.|. ......||.|...                               .     ..|...|.. .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................lydpellerlgiqylyl

DWPQDGVVrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRKSKPGAVTTLEQYTSIYD
 ||  ||   .. .|.... . .....  ||||.||||  |.|.|. .   . |        . ..... . ||. .||||.. .||  .|.
pwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyy
subfamily_PTPN3_pd Subfamily PTPN3 1730-1905 1.5e-27 91.3 In-house 84-271 (280) alignment 
Range on Protein: 1730-1905
Range on HMM: 84-271/280.0
KAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE----EDCCYPYWT---GLSTHDDFVVEIANEIKSNGYIERMLNVE------SRNVLQLQVTDWPQ
. .|..| |...|| |||.|. . |.| ||||          |. ||      ... .| |.. .| ... |. | | ..      .|..|||| ..||.
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpd

DGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVI
 ||  ..  .|.... | .....    |||||||  . |.||.  . . |    |.  | . .. . .|  .   | | .||. . . |
hgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1413-1645 1.8e-27 90.6 In-house 50-280 (302) alignment 
Range on Protein: 1413-1645
Range on HMM: 50-280/302.0
ENKYLNRFQQITVYDDNRIILTpnpnlyMCEREYINASYIDGYSSSNKFIATQGPMVNTL---ADFWRLIWQERPMHIVMLTDPKECIKnkWCEQYWPRA
.|   |. ... ..|.|...|.      ... .|.||| ..  . ... | .| | |..    ..|||...||.  ..|.|  ..|. |    ....|. 
knlkknqsedvpildsnlvkle......aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk..tlselfpkk

LMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPKPLLSLHKQVMAT---WSPSEGPILVHCSAGVGRTGTFIAIDIA
  . ...| . |    | .    . |    ..|.|  .|   . |.|| |... ||.   .| |...      .... ....    |.|| |.|..  .|
sgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

LEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.|. ...  . |. ||. .|.|| ..|..|.|||.|. |
veklqkgkepnikeivksiRsqRpravdslkQyvslyia
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1547-1690 1.8e-27 90.8 In-house 87-233 (440) alignment 
Range on Protein: 1547-1690
Range on HMM: 87-233/440.0
DSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATW-SPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFL
.|.|| |||  .|||.||||   |.| . ..|  .    ..||.|||||||.||||  ||.|  | .| |   .||  ..| .|..| .|||| .||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDAVFsETIIGGETEIPADKFATKLQELKEIDSSTGCSGLQSQFELLS
|.||. | .. |.| |  |  . ......  .  |  | || .||  |
heavl.egllcgdtliledditerveqiqwpnphtdksplqqefegys
subfamily_PTPN13_pd Subfamily PTPN13 1714-1910 4.6e-27 90.0 In-house 59-270 (273) alignment 
Range on Protein: 1714-1910
Range on HMM: 59-270/273.0
SNSYTNPSFTAGY--HDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED----CCYPYWTG-----LSTHDDFVVEIANEIKSNGYIERMLNV-
. .| | |.      .|.  .|..| |. .|..|||.|. . |.. |.|.  | .     |  ||       |  .. . ||  .  | .|.  | |.| 
eggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk

-----ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLE
     |||.| .|. ..||  || ...  .||..  | . |.    ||.|||||  . |||.. .. . |.  . .  .|| .. . .|. . | | | .
dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkd

QYTSIYDVIDMYLQ
||  .| .|   |.
qyifvykailevlk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1714-1905 1.3e-26 87.9 In-house 72-232 (392) alignment 
Range on Protein: 1714-1905
Range on HMM: 72-232/392.0
SNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG--EEDccypywtglsthddfvveianeiksngyiermLNVESRNVLQLQV
 . | | |.  ... .||.| .|.|   .  |||.|. . .|..|.|.    | |                                   . | | | ..
dsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd................................kgddartvaqfhf

TDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVI
|.||...| .   ..|..| .|     .    |...|||  | |.||  |.   . ..|   .||||..   .|. .|  | | |||. ||  .
tewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_PTPN14_pd Subfamily PTPN14 1714-1911 1.5e-26 88.1 In-house 75-298 (300) alignment 
Range on Protein: 1714-1911
Range on HMM: 75-298/300.0
SNSYTNPSFTAG--YHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE----EDCCYPYWTGL------STHDDFVVEIANEIKSNGYIERMLNV
|. | | |         .. .|.||.|.|.| .|||.|. . .|. ||||  |     . .. |.  |       ... | |      .|. .| . |..
stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglkl

------ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDV---IH-RQQKI----GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKS
      | |.|. || ||||..|| ..... |. ...|    .  ....       ||.||||. | |.||   . . ..  . . ..|. .| . .|. 
khlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreq

KPGAVTTLEQYTSIYDVIDMYLQM
.   | || ||. .|.|.  ||. 
rmllvqtlaqYkfvYkvlikylkn
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1710-1905 2e-26 87.7 In-house 23-235 (237) alignment 
Range on Protein: 1710-1905
Range on HMM: 23-235/237.0
KNQGSN-SYTNPSFTAGYHD-KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTGLS---THDDFVVEIANEIKSNGYIERMLN
|  ||.  | | ..  |.    | .| || |.|..  |||.|. . | | |||| |    .|  |. ||       ..  . | .  . .   |  | | 
kgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrsll

VE-------SRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAV
.         | . | | | ||. || ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  ... . .|  .
lskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyii

TTLEQYTSIYDVI
 | .||  |...|
qtkdqyvfihqti
0048076 (Phosphotyrosine protein) phosphatases II 1504-1645 2.6e-26 87.4 In-house 1-138 (145) alignment 
Range on Protein: 1504-1645
Range on HMM: 1-138/145.0
QYWPRALMEEEKFGPFIvTLTNVANHPSFTIRSLNVIIPDGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMaTWSPSEGPILVHCSAGVGRTGTF
.|||    .   .|..  |  ....  .. |. .  . .. .. ... .||. ..|||||||     ||.. ...  .. ...||.|||||||||||||.
pywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefie.ealkeggpvlVHCsaGvgRtgtl

IAIDIALEqadrEGvVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
.|... |.    .| |..  .....|.||...|.. .|. ||...
vaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyef
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1422-1647 3.8e-26 86.9 In-house 26-256 (290) alignment 
Range on Protein: 1422-1647
Range on HMM: 26-256/290.0
QITVYDDNRIILTPNPNLYmcEREYINASYIDgYSSSNKFIATQGPMVNT-------LADFWRLIWQERPMHIVMLTDPKECIKN-KW--CEQYWPRALM
....  ..|..|    . .    .|| |...  ...  ..|.|| |  ..       . .|| .. ||.  ..||| . .|  .| ..  |..| | .  
evpLveatrvvLkgygkrf..nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg

EEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDGsnDSHTLTQYHLTSWPDHGVPKPLLSLHKQVMATWsPSEGPILVHCSAGVGRTGTFIAIDIALEQAD
|| ||. . |  ..  ..  . .| | |   |.    .|.| . | .| .  |..  ..| . ..     |. |..|||  |. |  .. ||...     
eelkfkgltvkCkskekeddvetRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkvk.asktpvivHcvdGiSrsAalaaiilgyQkia

-REGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
  .| | .. ... ||.|| .....  .. |   ...
etsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1712-1912 4.9e-26 86.2 In-house 62-280 (287) alignment 
Range on Protein: 1712-1912
Range on HMM: 62-280/287.0
QGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE-ED---CCYPYWTGL----STHDDFVVEIANEIKSNGYIERML---N
.   .| |  . |.|.|..||| ||.|.  | ||||..... ........  | |.    || ||             || .  .||.  |  | |   .
elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlid

VESRN---VLQLQVTDWPQDGVVRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVT
.|.|.   | ||.. .||....        | ||.| . .  ...  . ||.|||..  . |||.. .. . ... .  | ||| .|   .|. . . | 
letrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvq

TLEQYTSIYDVIDMYLQMN
.  |.  .|. .  | . |
avvqlrllyealvtyyktn
0046846 (Phosphotyrosine protein) phosphatases II 1713-1909 2.6e-25 84.6 In-house 10-173 (176) alignment 
Range on Protein: 1713-1909
Range on HMM: 10-173/176.0
GSNSYTNPSFTAGYHdkkaFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYWTGLS---Thddfvveianeiksngyiermlnvesrn
.. .| |... .|..    .|. | |...|  ||..|. .....|.|.|. | .     |. ||  |                                 
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

vlQLQVTDWPQDGVVREpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRKSKP-GAVTTLEQYTSIYDV
  | ....||  ||    . .|.... .  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| |||  .|..
..qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyef

IDMYL
. ..|
ellll
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1414-1647 6.6e-25 82.4 In-house 43-273 (312) alignment 
Range on Protein: 1414-1647
Range on HMM: 43-273/312.0
NKYLNRFQQITVYDDNRIILTPNPNLymcereYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRA--LM
 | |||. .| ..|  |. |. . |.      || | ..   .  ..|..||||. || . ||.|        |..|.   |   .| | .|      ..
fkdlnrypniqcwdrgrftlagdenf......yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsek.cakyisdivgfv

EEEKFGPFIVTLTNV--A--NHPSFTIRSLNVIIPDGSNDSHtLTQYHLTSWPDHGVPKPLLSLHKQVMATwSPSEGPILVHCSAGVGRTGTFIAIDIAL
. |    .    |..      .   | | |.|..    ..|. | .|  .||||||.|    . .. . |       |.. |||||||||||.. |.  .
dledhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsav.kkdkkpviahcsagvgrtgtlaliesmi

EQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
         ..  .   ||..| . |... |||.   .|.
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvl
0049260 (Phosphotyrosine protein) phosphatases II 1724-1903 2.4e-24 81.2 In-house 3-144 (152) alignment 
Range on Protein: 1724-1903
Range on HMM: 3-144/152.0
AGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDC----CYPYWtglsthddfvveianeiksngyiermlnvesrnvlQLQVTDWPQDGV
 ||. ...||..| |..||. |||.|. ......||||. ...     |. |.                                   | . . || .||
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...................................qylhlpwpDhgv

VREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYD
   .  .|.... . .. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .|.
pdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0048179 (Phosphotyrosine protein) phosphatases II 1522-1644 3.9e-24 80.4 In-house 18-139 (144) alignment 
Range on Protein: 1522-1644
Range on HMM: 18-139/144.0
TLTNVANHPSFTIRSLNVIIPDGSNDSHTLT--QYHLTSWPDHGVPKP---LLSLHKQVmATWSPSEGPILVHCSAGVGRTGTFIAIDIALeqadREGvV
|. ....  .. |. .  ....  ... . .  ||. ..|||||||     ||.. . .  .. ...||.|||||||||||||..|... .    ..| .
taldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefi.eealeeggpvlVHCsaGvgRtgtlvaaylmk....klg.l

DIAGIVNRLRQQRMKMVQTLDQYVFLHD
..  .....|..|. .|.. .|. ||..
sleealalvrsrrpgavpnpgqlrfLle
PTPc_DSPc_SM00012 1806-1905 7.5e-24 79.3 In-house 2-103 (105) alignment 
Range on Protein: 1806-1905
Range on HMM: 2-103/105.0
VLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRKSKPGAVTTLEQYTSIYD
| ....|.||. || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...| . ||.||. |..||..||.|.|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1711-1902 1.6e-23 78.1 In-house 32-234 (239) alignment 
Range on Protein: 1711-1902
Range on HMM: 32-234/239.0
NQGSNSYTNPSFTAGYHD-KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTG-LSTHDDFVVEIANEIKSNGYIERML-----
|.  . | | |.   |    ||.| .|  .| .. |||.|. . .   |||| |     .  |. ||    | . .. | . .      || | .     
ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqv

-NVESRNVLQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQY
 . | | | | ..| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|. .|  | | |||
gqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy

TSIY
  |.
vfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1711-1902 1.6e-23 78.1 In-house 31-233 (239) alignment 
Range on Protein: 1711-1902
Range on HMM: 31-233/239.0
NQGSNSYTNPSFTAGYHD-KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTG-LSTHDDFVVEIANEIKSNGYIERML-----
|.  . | | |.   |    ||.| .|  .| .. |||.|. . .   |||| |     .  |. ||    | . .. | . .      || | .     
ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqv

-NVESRNVLQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQY
 . | | | | ..| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|. .|  | | |||
gqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy

TSIY
  |.
vfih
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1417-1571 2.7e-23 77.3 In-house 36-186 (297) alignment 
Range on Protein: 1417-1571
Range on HMM: 36-186/297.0
LNRFQQITVYDDNRIILTPNPnlymCEREYINASYIDG--YSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALMEEE
 ||...|  .||.|. |   .     ||.|||| |.      .  |.| .|||. .|. |||.|....    |||..  .|  ..| |  |||..  |  
knryrdilatddtrvkllrvi....terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdk.capywpsvvqerl

KFGPFIVTLTNVA--NHPSFTIRSLNVIIPdgsNDSHTLTQYHLTSWPDHGVPKPLLSL
| | ..|        ..    .  |..|     ..|  ..     ||||||||  |  |
kagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledl
RBD Raf-like Ras-binding domain 139-206 4.7e-23 67.3 Pfam-A 2-69 (71) alignment 
Range on Protein: 139-206
Range on HMM: 2-69/71.0
LIRAHLPEGQRTIVPIRQGVTIQDALMKAMKTRNLTPNTCIVYAESPRLLIEWDTDTTQLSGKEVFVE
.||.||| .||. | .|.|.|..|||.||.|.|.|.|  | |.. . .  . ..|| . | |.|..||
tirvhLPnnqrsvvevrpGmtvrDaLskalkrrgLnpsacaVrlvgekkpldletdissLpgeelive
subfamily_PTPN1_pd Subfamily PTPN1 1711-1902 5.2e-23 76.2 In-house 52-264 (290) alignment 
Range on Protein: 1711-1902
Range on HMM: 52-264/290.0
NQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC----GEEDCCYPYWTGLST-------HDDFVVEIANEIKSNGYIERML
....| | | |.    . |. .|..| |. ||.  ||.|. . |  |.|||      |.  |. ||            .  . |.. .| ... |. |.|
eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrll

NVES------RNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRKSKP
..|       |..|.   | ||  || . | . |. . .| .    .   ||.|.|||  . ||| .| |   | . ....    ||. .|  ..|| . 
elenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrl

GAVTTLEQYTSIY
| . | .|    |
Gliqtadqlrfsy
0051082 (Phosphotyrosine protein) phosphatases II 1716-1904 1.5e-21 72.0 In-house 4-148 (151) alignment 
Range on Protein: 1716-1904
Range on HMM: 4-148/151.0
SYTNPSFTAGYhdkkaFIIAQSPMEntarDFWKMIVDYKVSAIVMLCG--EEDCCYPYWTGLSthddfvveianeiksngyiermlnvesRNVLQLQVTD
.|.| |.  |.     ... . |..    ||.... ......||.|..  | . |. |.. |.                           ..||.....|
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...........................ievlhipild

WPQDGVVREPRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRKSKPGAVTTLEQYTSIYDV
||  |.   . .||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. .
wpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_PTPRN_pd Subfamily PTPRN 1711-1903 3.5e-21 70.2 In-house 80-286 (297) alignment 
Range on Protein: 1711-1903
Range on HMM: 80-286/297.0
NQGSNSYTNPSFTAGYHDK-KAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED----CCYPYW--TGLSTHDDFVVEIAN-EIKSNGYIERM----
.. .. | | |.      .  |.| .|.|. .|  |||.|. .  |  ||.|.  |.     |. ||  .| .... . |..    | .. |. |     
saeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylk

--LNVESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIhRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRKSKPGAVTTL
   . |.| | |.    ||. ||  .....|.    |  .  .    |.|||||| . |.|||. . . |..  |    .|.    . .|  .|| | | 
nlqtsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktk

EQYTSIYD
.|.  .. 
dqfefalt
subfamily_CG42327_pd Subfamily CG42327 1443-1571 1.4e-20 68.2 In-house 55-186 (319) alignment 
Range on Protein: 1443-1571
Range on HMM: 55-186/319.0
EREYINASYIDGYSS-SNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECiKNKWCEQYWPR--ALMEEEKFGPFIVTLTNVANHPSFTIRSLNV
. ||..|||. || .  | .||.| .. .. .||||..|. .   || |||. |    | | .|.|   .| ... .| . ||| . . .  . | .| .
kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlsel.GikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll

IIPDGSnDSHTLTQYHLtSWPDHGVPK---PLLSL
   |..  |  || |    |.. .||    .|...
krvdke.esrelthywy.kwleaevPaeeaaliam
0049772 (Phosphotyrosine protein) phosphatases II 1715-1913 4.8e-20 68.0 In-house 72-284 (314) alignment 
Range on Protein: 1715-1913
Range on HMM: 72-284/314.0
NSYTNPSFTAGYhdkKAFIIAQSPMENTARDF----------WKMIV--DYKVSAIVM---------------------LCGEEDCCypywtGLST----
 .| | |.  |.   ..||..| |.|.|  ||          |.|..  |..|  |||                     |..          .. |    
sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadl

---HddfvveianeiksngyiERM--LNVESRNVLQLQVTDWPQdGVVREPRTVLQVIdDVIHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCkae
   .                 |..   .  .|.....  ...|  | .  .. ..... ..|..     ||||.|||.. ..|.|... . . . ..   
ellk.................eelydpelferlgikylripvpD.gsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...

GVvDVFQVTKAVRKSKP-----GAVTTLEQYTSIYDVIDMYLQMNK
|| .. .. . ||.  |     |.. .||||  |.... .||.. |
gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1729-1905 9.5e-20 65.4 In-house 93-279 (290) alignment 
Range on Protein: 1729-1905
Range on HMM: 93-279/290.0
KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE----EDCCYPYWT---G-LSTHDDFVVEIANE-IKSNGYIERMLNVES------RNVLQLQVTD
|  ||..| ....|. |.|.|... ||.||||||         | .|.    |   |  .. |  ..|  | .  | ..| |          .  |..  
kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkiks

WPQDGVVREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLeQCKAEG-VVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVI
||.  |     ..|...  .  |.     ||||||||  . |.| . .. .|| |.  .|  .|. .. .|.|.|. ..|    ||  . ...
wpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1453-1642 7.8e-19 62.2 In-house 84-280 (302) alignment 
Range on Protein: 1453-1642
Range on HMM: 84-280/302.0
DGYSSSNKFIA-TQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALMEEEKFGPFIVTLTNVAN-HPSFT------IRSLNVIIPDG
||    .|       |  .||  .| || | .   .| |.. .|  ..| | .|.   . .| ||| . |.  .| .    ||      . ....     
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekk.caeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

-SNDSHTLTQYHLTSWPDHGVPKPLLSLHkQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFL
 ..  .|.   . ..||||| ||   .   ...         .|||||||||||||..||   ..   .. | |.. ||  .|| |   ||. .| ..|
kkkvkktvdilafsawpdhGapkeaytal.dilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1778-1905 1.9e-18 61.0 In-house 61-190 (440) alignment 
Range on Protein: 1778-1905
Range on HMM: 61-190/440.0
HDDFVVEIANEIKSNGYIER-MLN-VESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV
|   ..|  . . .. ||.  ..| .||| . | .   ||. || .    ||..|.|| . |.| | ||..||||  ..|.||  .|   | ..|    .
hsrvmleevkgvpdsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqi

DVFQVTKAVRKSKPGAVTTLEQYTSIYDVI
|.| . ...|...|  | | |||. .....
difsfinsmrnnrpqmvqtpeqyafvheav
0044763 (Phosphotyrosine protein) phosphatases II 1732-1912 3e-17 58.3 In-house 30-174 (178) alignment 
Range on Protein: 1732-1912
Range on HMM: 30-174/178.0
FIIAQSPMentaRDFWKMIVDYKVSAIVMLCGEEDCC----YPYWTGLSThddfvveianeiksngyiermlnvesrnvL---QLQVTDWPQDGVVREPR
..... |.     |..... ......||.|..|  .     .|||                                  .   .. . |..   . .  .
lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.............................iqylhipipDhgvpdllehfl

TVLqvidDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRKSKPgAVTTLEQYTSIYDVIDMYLQMN
 ..    . |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .|.  .|..  ..|...
efv....efieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrllkes
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1471-1636 3.5e-17 57.3 In-house 40-207 (255) alignment 
Range on Protein: 1471-1636
Range on HMM: 40-207/255.0
TLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDgSNDSHTLTQYHLTSWPDHGVPKPLLS
|.. |.. | | ..  .|||.| .|  ..| |..|.|  . |  |.    || |. .... .  . .   . .     ||.. |. . |...  |.    
tvdkfyqtivqtktevvvmlcdfaeegvek.cssyfplekdeklkladvnvtttkssadvvlrtleitstlge.kkkthtvkhysykGWieknaPelare

LhKQVMATWSPSeGPILVHCSAGVGRTGTFIAIDIALE------QADREGVVDIAGIVNRLRQQRMKMVQTL
. ....     |  ...||||.|.||. .|. ....        .    . .|   ... ||..| . ..| 
i.lnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtP
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1719-1909 1e-16 55.8 In-house 71-277 (307) alignment 
Range on Protein: 1719-1909
Range on HMM: 71-277/307.0
NPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGLSTHDDFVVEIANEIKSNG-------YIERMLNV------
   .     . | || || |.|||  .|| |... || ...|||   .     |  ||          .| .| |  .          | ..||      
hanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvd

---ESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIGLEQ-CKAEGVVDVFQVTKAVRKSKPGAVTTLEQ
   .|| . .|| ..||. || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|. .. |. |  |
waqksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaq

YTSIYDVIDMYL
|  .. |.  |.
ylylhrvlleyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1580-1648 1.2e-16 55.5 In-house 225-293 (297) alignment 
Range on Protein: 1580-1648
Range on HMM: 225-293/297.0
SPSEGPILVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFS
 | . ..||||||||||.|  .  |. |..  .. . |.| |.. ||.|| ..||||.|. .|.|||. 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 1582-1645 1.2e-16 55.3 In-house 246-310 (319) alignment 
Range on Protein: 1582-1645
Range on HMM: 246-310/319.0
SEGPILVHCSAGVGRTGTFIAIDIALEQADRE-GVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDA
| ||. |||| ||||||. || |||... .     |||  .|  .|..| . |.| .|| |..  
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1584-1646 1.3e-16 55.3 In-house 263-340 (350) alignment 
Range on Protein: 1584-1646
Range on HMM: 263-340/350.0
GPILVHCSAGVGRTGTFIAIDIALE-------------QADREG-VV-DIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
 |||||||||||||||....|  |.             . |.   .   |  |||.||.||..|||.|||..|...|.
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeal
C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) 219-265 3.1e-16 48.9 Pfam-A 1-51 (53) alignment 
Range on Protein: 219-265
Range on HMM: 1-51/53.0
HNFVRKTFIALAFCDVCKKLL----FQGFRCETCGFRYHQRCSPRVPIQCG
|..|...|   .||..|.|.|    .||..|..|....|..| ..||..||
HhwvhrnfkqptfCkhCgkflwgkgkqglkCswCqllvHkkCfekvpkecg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1730-1905 6.4e-16 53.1 In-house 76-291 (297) alignment 
Range on Protein: 1730-1905
Range on HMM: 76-291/297.0
KAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC----GEEDCCYPYWTG----LSTHDDFVVEIANEIKSNgYI-----E--RMLNVESRNVLQLQVTDW
  .|.|| |...|  |||.....  | .|||..    .  | |.|||        .  |.|||   .   . .      |   .   ||| |   |   |
lkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflsw

PQDGVVR----EPR-------------TVLQVID---DVI------HRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSK
|. ||        |              .| ...    ..       | ..    ...||||  | ||||     . |.. . . . ||  . . .|. .
pdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqr

PGAVTTLEQYTSIYDVI
.  | ||||.. .||..
arlvqtleqfellydav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1711-1905 1.6e-15 51.6 In-house 62-265 (281) alignment 
Range on Protein: 1711-1905
Range on HMM: 62-265/281.0
NQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG----EEDCCYPYWTG----LSTHDDFVVEIANEIKSNGYIERMLNV-
|. |  |    .      |. .|..| | ..|  |||.|| . . .||||||     . . |  |.          | . |.  .    .  .   ||. 
nknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls

---ESRNVLQLQVTDWPQDGVVREPRTVLQVIddvihRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRKS-KPGAVTTLE
   |.| . .    .||.  |      .|...     |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| . .  .| ||.
yegetrlithwlwkewpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlq

QYTSIYDVI
||  |. |.
qymliwkvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1417-1514 1.8e-15 51.5 In-house 50-158 (350) alignment 
Range on Protein: 1417-1514
Range on HMM: 50-158/350.0
LNRFQQITVYDDNRIILT-----PNP-NLYMCEREYINASYIDGY------SSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQ
 ||...|  |. .|..|      ..  .  .   .||||.|.          .. |.||||.|. .|. ||...| .     |..||.  |   .| |..
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek.cyr

YWPRALMEEE
||..  ... 
YWqegsyddi
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1729-1898 2e-15 51.3 In-house 89-270 (301) alignment 
Range on Protein: 1729-1898
Range on HMM: 89-270/301.0
KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE----EDCCYPYWTGLSTH----DDFVVEIAN--EIKSNGYIERMLNVE-------SRNVLQLQV
 . ||..|.|..||. ||| |.| |.|  ||||. .    |. |  | .   ..    . | ..| |   | ..  ..| |.||       .| |.  | 
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqy

TDWPQDGVVREPRTVLQVIDdVIHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQY
..|.. || .    . .... .. . .|    |.|||||. . ||  . .  .   . .|.  ... .  | .|. .  .| | .| 
sewtdrgvPkshaelfdlme.lvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1728-1912 3.2e-15 51.0 In-house 58-262 (290) alignment 
Range on Protein: 1728-1912
Range on HMM: 58-262/290.0
DKKAFIIAQSPMENT-------ARDFWKMIVDYKVSAIVMLCGEED---------CC--YPYWTG-LSTHDDFVVEIANEIKSNGYIERMLNVESRNVLQ
.  ..|. ||| |..         .|| |. . ||  .||||  |.         |   .|   |   . ... |.  . .| .. ..| | |.  .  .
nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeee

L-----QVTDWPQDGVVREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIY
.     .. .| .  | ....|.|..|. |  ..      ||.||| | .||| .  .. .|       .| | . .| ||.|| .  |.|. .... . 
ftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd

DVIDMYLQMN
 .| ....  
agivllaiev
subfamily_hpo-7_pd Subfamily hpo-7 1468-1635 4.7e-15 50.2 In-house 43-212 (263) alignment 
Range on Protein: 1468-1635
Range on HMM: 43-212/263.0
MVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWPRALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIPDgSNDSHTLTQYHLTSWPDHGVPKP
.|.|.. |.. | | ..  .|||.| .|  ..| |..|.|  . |  |.    |. |.| . .    . |  .. .     ||...|  . |...  |. 
lvqtidkfyqtivqtktevvvmLcDfneegvek.cssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekndpel

LLSLHKqVMATWSPSeGPILVHCSAGVGRTGTFIAIDIALE------QADREGVVDIAGIVNRLRQQRMKMVQT
  .  . ..     |  .. ||||.|.||.  |  ....        .    . .|   ... ||..| . ..|
areiln.ilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht
0048076 (Phosphotyrosine protein) phosphatases II 1761-1908 2.6e-14 48.6 In-house 36-142 (145) alignment 
Range on Protein: 1761-1908
Range on HMM: 36-142/145.0
LcgeedccypywtglsthddfvveianeiksngyiERMLNVESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYC
|                                   ..|. ..|...|.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.|...
l..................................tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv

svsiGLEQCKAEGvVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMY
    ..  .. .| |..... . ||.  ||||.. .|.  .|... ..
....aaylmlllg.vsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1587-1647 2.7e-14 47.3 In-house 2-62 (69) alignment 
Range on Protein: 1587-1647
Range on HMM: 2-62/69.0
LVHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
.||||.| ||||||||| . . .   | .|||   |. .|. |  ||    .|.|.|||. 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1728-1909 3.7e-14 47.1 In-house 94-289 (305) alignment 
Range on Protein: 1728-1909
Range on HMM: 94-289/305.0
DKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE----DCCYPYWTG-----LSTHDDFVVEIANEIKS---NGYIE-RMLNVES-----RNVLQL
 .| || || |...|  .|| |... ||  |||||         |  ||       |. .   |||     |    .  |.  .||.         | .|
pekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhl

QVTDWPQDGVVREPRTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIGLEQCKA-EGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMY
| |.||. ||     | |...  .  |  |.   |.|||||  . |.|   ..   ||.      .  . .. ||.|  .  .. .  ||  |. |.  |
qwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny

L
.
f
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1588-1647 3.8e-14 46.8 In-house 2-61 (69) alignment 
Range on Protein: 1588-1647
Range on HMM: 2-61/69.0
VHCSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVF
||||.| ||||||||| . . .   | .|||   |. .|. |  ||   ..|.|.|||. 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_egg_pd Subfamily egg 1730-1910 2.2e-13 44.6 In-house 83-271 (307) alignment 
Range on Protein: 1730-1910
Range on HMM: 83-271/307.0
KAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE--DCCYPYWTGLSTHDDFVVEIANEIKSNGYI---ERM-----LNVESRNVLQLQVTDWPQDgv
  ||.||.|. ||  |||.|.   .|  ||||      . |  ||    ..   .|  . .|.. .     . .     |..   .  .. .  |  |  
nefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgd..

VREPRTVLQVIDdvIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV--DVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQ
|..   |   .   . |. .    ||||.. . ||....  .. | | .     ..   | .  . .|. .. .| .  .|  .| .. ....
vnnssdvysplr..vlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
0048179 (Phosphotyrosine protein) phosphatases II 1748-1903 4.6e-13 44.6 In-house 23-139 (144) alignment 
Range on Protein: 1748-1903
Range on HMM: 23-139/144.0
KMIVDYKVSAIVMLCGEEDCCYPYWTglsthddfvveianeiksngyiermlnvesrnVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVV
... ........ |. | .  ..  .                                ..|.. ..||  ||   .  .|.... . . ..   ||||.|
ellkklgittvinlteeyepeflere................................giqylhlpwpDhgvpdllellleflefieeale..eggpvlV

HCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRKSKPGAVTTLEQYTSIYD
|||  |.|.|...        .| .| ...... . ||.  ||||.. .|.  ...
HCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1711-1912 1.4e-12 41.6 In-house 70-288 (302) alignment 
Range on Protein: 1711-1912
Range on HMM: 70-288/302.0
NQ-GSNSYTNPSFTAGYHDKKAFIIAQSPMENTA---RDFWKMIVDYKVSAIVMLCGEEDC------CYPYWTG-LSTHDDFV-----VEIANEIKSNGY
..   .|| | | .   . ..  |.|| |  ...    .||.|. . |.  .|.| |||..       .|  .|  ......      || |.| |.. .
leaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryv

IERMLNVESRNVLQL--QVTDWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAV
|| . .  |  ||     .| |.|. |  .  .. . . .| . ..  .  ..|.     . | |.  .. . .|. ...  . . .. |..|. .| ||
iEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRprav

TTLEQYTSIYDVIDMYLQMN
 .|.||.|.| .. .|.. .
dslkQyvslyialllyikkk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1729-1904 1.5e-12 42.1 In-house 4-199 (199) alignment 
Range on Protein: 1729-1904
Range on HMM: 4-199/199.0
KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE---DCCYP-YWTG----LSTHDDFVVEIANEI-KSNGYIERML-------NVESRNVLQLQVT
.. .| .| |. .|  |||.|. .     |||.  ..   .. || ||       . .  . |       |..  |  ..          .|.. . | |
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDV
 | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1729-1904 1.5e-12 42.2 In-house 3-198 (198) alignment 
Range on Protein: 1729-1904
Range on HMM: 3-198/198.0
KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE---DCCYP-YWTG----LSTHDDFVVEIANEI-KSNGYIERML-------NVESRNVLQLQVT
.. .| .| |. .|  |||.|. .     |||.  ..   .. || ||       . .  . |       |..  |  ..          .|.. . | |
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDV
 | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1417-1653 2.8e-12 40.9 In-house 50-281 (303) alignment 
Range on Protein: 1417-1653
Range on HMM: 50-281/303.0
LNRFQQITVYDDNRIILTpnpnlymcEREYINASYIDgYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVM-LTDpKEcIKNKWCEQYWPRALmEEEK
 ||| .. . |  .. |.        .  || |||..   ||.| | || |.  | ||||..| ...   ... |||  |  ..   .  .||   .  |
knrfvdvicldhskvkls........dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltd.se.ydklggdsvfprnq.dflk

FGPFI---VTLTNVANHPSFTIRSLNViiPDGSNDShTLTQYHLTSWPDHGVPKP-LLSLHK------QVMATWSPSEGPILVHCSaGVGRTGTFIAIDI
|         . .|     .... | |   .|.  |  |  .|  .||   .|      . |       |.  .|.|. .. .  | |.||.|||  .. 
feersirvgefkrvelgdgwvlkvlsv..sngdyks.flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls.gcgragtfalfet

A-LEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDaVFSETIIG
| |   . .  .|.   .. .|. |.. || | |. ...  ...| ...
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvyt.llaehvld
subfamily_CG42327_pd Subfamily CG42327 1841-1909 1.2e-11 38.9 In-house 246-315 (319) alignment 
Range on Protein: 1841-1909
Range on HMM: 246-315/319.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYL
  ||.|||||| | |.|.  .  | ... .     ||. |.   ||. .  || | |||  || |. .| 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1453-1538 1.4e-11 38.4 In-house 230-310 (440) alignment 
Range on Protein: 1453-1538
Range on HMM: 230-310/440.0
DGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDpkecIKNKWCEQYWPRALmEEEKFGPFIVTLTNVANHPSFTIRSLN
.|||  | ||||| |.  |. |||||. . |   |.|| .    ...| |  |||        |||| |      |     .|.|.
egyskknafiatqmpldstvldfwrlvhdyristiimlnq....lndktcsiywpvnt.rsvtfgpftvghkgsenmnrvkvrtle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1584-1646 1.4e-11 38.3 In-house 266-340 (349) alignment 
Range on Protein: 1584-1646
Range on HMM: 266-340/349.0
GPILVHCSAGVGRTGTFIAIDIALE---QADREGV--------V-DIAGIVNRLRQQRMKMVQTLDQYVFLHDAV
 ..||||||| ||||... .|. |.      .| .           |  ||| ||.||. ||| | |......|.
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1726-1906 2.2e-11 37.9 In-house 90-287 (310) alignment 
Range on Protein: 1726-1906
Range on HMM: 90-287/310.0
YHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE--ED--CCYPYWTGLSTHDDF-VVEIANEIKSNGY-----------------IERMLNVES
 . ...|| .| |.. |  |||.|| . .  .|..||    |    |  ||  |   . . .. ..|  .|                     |.  |.. 
nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlke

RNVLQLQVTDWPQDGVVREP-RTVLQVIddviHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIY
  |  ..  .||. ||  |   || | .      |  .  ||.|||||  . | .| ... . ... .    ||. .|   ..||.   . |  ||. | 
lrvslikwpnwpdrgvpdekchtvpqrl....laq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid

DVID
 |  
rvri
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1707-1820 5.2e-11 36.6 In-house 114-236 (244) alignment 
Range on Protein: 1707-1820
Range on HMM: 114-236/244.0
DLAKNQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC--GEEDCCYPYWTGLSTH-DDFVVEIA------NEIKSNGYIER
 |.|   .|.| | ||         .|..| |. .|. |||||... .|  .|.|    |||  .|    |  . .|  | ..      |   ||  || 
plskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpdseplewyeeditvtltdrdefknikasnleies

MLNVESRNVLQLQVTDWPQDGVV
 .|   . .  .|...|| ||  
dmneshqaltmfqisnwpsdgtt
subfamily_eak_pd Subfamily eak 1408-1566 6.8e-11 36.1 In-house 46-196 (332) alignment 
Range on Protein: 1408-1566
Range on HMM: 46-196/332.0
VGYTDENKYLNrFQQITVYDDNRIILTPNpnlYMCEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKwCEQYWP
..   |.   |   .|  || . . ||.     . .  ||||| ..     .|.| |  .  . .  ||... ...   ||.| .  |   .|  ..|.|
etarleavnrn.vvkivpydrylvrltss...qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelklek.sdkyfp

RALMEEEKFGPFIVTLTNVANHPSFTIRSLNVIIpdgSNDSHTLTQYHLTSWPDHGVPK
    || ||| . |.  .  ..  .  | | .      |..| .  |..  | .  .||
dktreelkfGildverkefvkrniletrllelsk...GnethrvlhykvfGwtettlpk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1702-1773 1.1e-10 35.4 In-house 204-280 (440) alignment 
Range on Protein: 1702-1773
Range on HMM: 204-280/440.0
DNAGEDLAKNQGSNSYTNPSF----TAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED-CCYPYWT
|.  | . . |  | .|. |       ||  |.||| .| |.. |  |||... ||..|.|.||   .|  |  || 
dditerveqiqwpnphtdksplqqefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywp
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1801-1902 1.1e-10 35.4 In-house 185-281 (302) alignment 
Range on Protein: 1801-1902
Range on HMM: 185-281/302.0
VESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTS
   . |  |. . ||. |  .|. | |...      ...     |.||||  | |.|   ..  |.. |. . | |. .. . ||. . ||| . .| . 
kvkktvdilafsawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

IY
. 
ll
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1411-1564 2.5e-10 34.4 In-house 93-235 (244) alignment 
Range on Protein: 1411-1564
Range on HMM: 93-235/244.0
TDENKYLNRFQQITVYDDNRIILTPNpnlYMcEREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKEciknKwcEQYWPRAL
  .| . ||      .| ||. |.      |    |||||..     . ..| || |. .|  |||... .     .|.|   .|    .  ..||| . 
npnnswknregaglpfdfnrvplskg...sm.gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee....e..deywpdse

MEEEKFGPFIVTLTNVANHPsfTIRSLNVIIPDGSNDSH-TLTQYHLTSWPDHGV
  |       ||||.  .     |.. |. |    |.|| .|| . .. ||  | 
plewyeeditvtltdrdefk..nikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1392-1494 4e-10 33.7 In-house 17-120 (347) alignment 
Range on Protein: 1392-1494
Range on HMM: 17-120/347.0
EDQYLRLYTGNDrpCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNLYMC---EREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIV
 |. |  |. ..  .|.   . .   || ..  . |. |..|.|.            |||||.|    .|...| || |. .|. |||...   .   .|
fdenlanyspsk..ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv

MLTDPK
 . .|.
tifepi
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1717-1907 1.1e-09 32.4 In-house 69-274 (312) alignment 
Range on Protein: 1717-1907
Range on HMM: 69-274/312.0
YTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGE----EDCCYPYWTG---LSTHDDFV--VEIANEI----KSNGYI-ERMLNVE
|    |       . |...|.|.|||.  ||.. .    ..|..|||      . |  | .    .   .|     |   ||    ||.  |  |.|.| 
yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvv

SRN------VLQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYC---SVSIGLEQCKAEGVVDVFQVtkaVRKSKPGAVT
 .       . . | . ||. |.     | |...  | ....|    ||. |||  | |.|  .   |.   | . . . | |.| .   .|| .  .| 
vkatgqesklnhyqwaswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvr

TLEQYTSIYDVIDM
.. ||     ..  
vfpqyvyalrcvle
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1402-1680 1.2e-09 31.3 In-house 54-339 (346) alignment 
Range on Protein: 1402-1680
Range on HMM: 54-339/346.0
NDRPCTVGYTDENKYLNRFQQITV--YDDNRIILTPNPNLYMCEREYIN--ASYIDGYSSSNKFIATQGPMVN---TLADFWRLIWQERpMHIVMLTDPK
|   |   | ..   |||  .  |   . . | |.       |   |..    |.  .   .|.| .| | ..    . ||| .|.||. .|.| |  | 
nregcpkiydenrvqlnrpghedvnyinasvitlkdvsrrmacvpayvhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeq.ihlvylmvpd

ECIKNKWCEQYWPRALMEEEKFGPFIVT-LTNVANHPS-FTIRslnvIIPDGSNDSHTLTQYHLTSWPDHGVPK---PLLSLHKQVMATWSPSEGPILVH
. .||     .       .     ||    ..|.  |  .||     ..|.|  ||     .| . |     |    |.. . .| ..     .  . | 
dklkntttslfndenggyqytgkmfinnrradvsgdpkeytie....vlpegnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv

CSAGVGRTGTFIAIDIALEQADREGVVDIAGIVNRLRQQRMKMVQTLDQYVFLHDAVFSET--IIGGEtEIPADKFAT-KLQELKEIdsSTGCS
   | ||. .||    |..| .     .|  |.  ..|||   |... ||  ..  ||       ||  . | .|     ..|| ||  |  ||
slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggk.kapvnkdinrfidelaei..spacs
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1389-1466 3.2e-09 30.9 In-house 23-95 (95) alignment 
Range on Protein: 1389-1466
Range on HMM: 23-95/95.0
NKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNpnlymCEREYINASYIDGYSSSNKFIATQG
..|....  .      | ||| .. |   ||| .|  ||  |..|| .      . .|||| ..|||.  | .||.||
qefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttk.....rdsdyinacfvdgyarkncyiaaqg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1444-1507 5.9e-09 29.7 In-house 90-154 (349) alignment 
Range on Protein: 1444-1507
Range on HMM: 90-154/349.0
REYINASYID--GYSSSNKFIATQGPMVNTLADFWRLIWQERPMHIVMLTDPKECIKNKWcEQYWP
 .|||| |.    .|  .|.|||| |.  |. ||...|  ..   .. |.| ||   .|. ..|| 
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc.diywq
PTEN_1 1548-1602 6.7e-09 30.8 In-house 91-149 (196) alignment 
Range on Protein: 1548-1602
Range on HMM: 91-149/196.0
SHTLTQYHLTSWPDHGVPKPLLSLH--KQVMATWS--PSEGPILVHCSAGVGRTGTFIA
 .   .|.  ...|||.|     ..  |...  ..  |... .|||| ||.||.|| .|
fksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1727-1909 7.6e-09 29.9 In-house 72-270 (285) alignment 
Range on Protein: 1727-1909
Range on HMM: 72-270/285.0
HDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC-----GEEDCCYPYWTGLSTHDDFV-VEIA-NEIK---SNGYIERMLNV---E-----SRNVLQ
.|. ..| .| |. .|  |||.|| . |.. ..|||     | | |.  |   |     |   ||.  | |     | |   | |   |        . .
kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnh

LQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMY
.||  ||..    . | ....   | . . |    |..||||  | |.  .  .     .   .  ...... . .|  .  || .  |.  .| |.  |
vqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey

L
.
f
Kinase-like Kinase-like 687-790 8e-09 23.9 Pfam-A 158-261 (289) alignment 
Range on Protein: 687-790
Range on HMM: 158-261/289.0
GVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFG-LATVKTRWDGnEKVRQPTGSILWMAP-EVIRMeEPDPYTFYCDVYSFGVVVYELISGQLPYPHVQ
 . .|.|....| .....|..|. .  |..|.|. |......  . ..| . .   . .|  .  .. .   .|.  |.   |.|.| . . .||   ..
laanLqarglvhgkispdnflldekggvfLggftaLvragkkvvv.sevekalaPpellaekggyts.nttkmthkldaWqlGlviysiwclrlPftlla

DRDQIL
   .. 
eeasee
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1718-1798 1.1e-08 29.2 In-house 100-175 (350) alignment 
Range on Protein: 1718-1798
Range on HMM: 100-175/350.0
TNPSFtagyhdkkAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEED----CCYPYWTGLSThDDFVVEIANEIKSNGYIERM
 ||.|         .| .|.|. .|  ||.|.|.  ||  |..|  . .     || ||  .|  ||. | .|.  .. . |. .
inpdf........kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsy.dditvklaskwenimginds
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1714-1820 1.2e-08 29.3 In-house 12-127 (130) alignment 
Range on Protein: 1714-1820
Range on HMM: 12-127/130.0
SNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC--GEEDCCYPYWTGLS-THDDFVVEIAN-----EIKSNgYIER--MLNVES
 | | | ||       . .. .| |. .|. |||||...  |  .|.|    |||  .|    |    .| .| ...     .||.. ..|    ||   
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyeediivtltdrdefknikas.nleiesdlnesh

RNVLQLQVTDWPQDGVV
. .  .|...|| ||  
qaltmfqisnwpsdgtt
subfamily_PTPDC1_pd Subfamily PTPDC1 1554-1644 1.5e-08 29.3 In-house 85-170 (182) alignment 
Range on Protein: 1554-1644
Range on HMM: 85-170/182.0
YHLTSWPDHGVPKPLLSLHKQVMATWSPSEGPILVHCSAGVGRTGTFIAIDIALEQAdregvVDIAGIVNRLRQQRMKMVQTLDQYVFLHD
..  .|.|.||.     |    ... . .|| . ||| || ||||  ||  .   .      .. .  .. .|..| | .|| .|  ....
vynfgwkDygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1806-1913 2.3e-08 28.4 In-house 173-275 (288) alignment 
Range on Protein: 1806-1913
Range on HMM: 173-275/288.0
VLQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVI
| .| . .|..|||  .  . |.... . .  ||    |.|||.|  | |.|    . | ||. . .  . . .. .  |...  |..|  ||  .. ..
vkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv

DMYLQMNK
  .| . |
leelllkk
fn3 Fibronectin type III domain 1165-1238 2.6e-08 27.1 Pfam-A 3-79 (85) alignment 
Range on Protein: 1165-1238
Range on HMM: 3-79/85.0
PHYLTEVRKTNATITVGWFAFD--SSDADGYVVNITSDTGT--VQIVQVKGNSNnTITLNGLRELTTYSITVRAYQQL
|. |.    |. ..|. | . .  ... .|| |   ...|.   . ..|..... . ||.||.. |.|...|.|. . 
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1716-1763 6.7e-08 26.6 In-house 74-121 (305) alignment 
Range on Protein: 1716-1763
Range on HMM: 74-121/305.0
SYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG
 |    . .   . | || .|.|.|.|  ||| | .. || || ||| 
eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcn
zf-RING-like RING-like domain 232-257 6.9e-08 19.9 Pfam-A 1-28 (43) alignment 
Range on Protein: 232-257
Range on HMM: 1-28/43.0
CDVCKKLLFQGFRCET--CGFRYHQRCS
| .||..  || ||..  |  ..|. | 
CeqCkeiviqgvrCgnedCeiklHvdCl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1846-1909 7.4e-08 26.7 In-house 2-65 (69) alignment 
Range on Protein: 1846-1909
Range on HMM: 2-65/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYL
|||||    |.| . .. . . . |.| .||.|   . .|| .|  |    .|  |.| .   |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1801-1917 7.7e-08 26.4 In-house 183-295 (305) alignment 
Range on Protein: 1801-1917
Range on HMM: 183-295/305.0
VESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV-DVFQVTKAVRKSKPGAVTTLEQYT
 ..| | .    |||. ||     ..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  .. . .|. .  .. | .|| 
ekarkvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqyl

SIYDVIDMYLQMNKADDD
 ...||  |.. .|  |.
fvhqvilnyfrkkkllde
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1413-1499 1.5e-07 25.2 In-house 33-116 (332) alignment 
Range on Protein: 1413-1499
Range on HMM: 33-116/332.0
ENKYLNRFQQITVYDDNRIILTPNPnlymCEREYINASYIDGYSSSNKFIATQGPMVN-TLADFWRLIWQERPMHIVMLTDPKECIKN
.|  .||  .. ..| .|. |.|.      . .. |||..||||  . .| .| |. . |   |||.. . .|  |... |  |  | 
nnmdmnriphlycfdhsrvelapqd....gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1443-1564 1.9e-07 25.5 In-house 12-126 (130) alignment 
Range on Protein: 1443-1564
Range on HMM: 12-126/130.0
EREYINASYIDGYSSSNKFIATQGPMVNTLADFWRLIWqERPMHIVMLTDPKECIknkwcEQYWPRALMEEEKFGPFIVTLTNvaNHPSFTIRSLNVIIP
. .|||||..     ..... || |. .|  |||...  || . ....    |       ..||| .   |      |||||.   . .  |.. |. | 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvlgsveee.....deywpdsePlewyeediivtltd..rdefknikasnleie

DGSNDSH-TLTQYHLTSWPDHGV
.  |.|| .|| .... ||  | 
sdlneshqaltmfqisnwpsdgt
subfamily_ptpA1_pd Subfamily ptpA1 1714-1769 1.9e-07 25.1 In-house 74-132 (418) alignment 
Range on Protein: 1714-1769
Range on HMM: 74-132/418.0
SNSYTNPSFTAGYHDkKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEEDCC----Y
 . | |  .  | .  | || .| |. ||  |||.|. . ..  ||||  | . |     
gsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcd
0038934 (Phosphotyrosine protein) phosphatases II 1553-1603 2e-07 26.3 In-house 81-135 (194) alignment 
Range on Protein: 1553-1603
Range on HMM: 81-135/194.0
QYHLTSWPDHGVPKPLLSLHKQVMAT--W--SPSEGPILVHCSAGVGRTGTFIAI
.|.   .||.|.. .|  |.. . .   .    ..| ..||| ||.|||||..| 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1846-1911 2.3e-07 25.1 In-house 1-66 (69) alignment 
Range on Protein: 1846-1911
Range on HMM: 1-66/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQM
|||||    |.| . .. . . . |.| .||.|   . .|| .|  |   ..|  |.| .   |..
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1374-1456 3.9e-07 23.7 In-house 5-87 (440) alignment 
Range on Protein: 1374-1456
Range on HMM: 5-87/440.0
PISINDLVNHI--AKYSNKFEDQYLRLYTGNDRPCTVGYTDENKYLNRFQQITVYDDNRIILTPNPNlyMCEREYINASYIDGYS
|| . |.....   . |  |||..  | .|  .|. .    .||  ||...| .|| .|..|       . . .|||||||.|  
piivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkg..vpdsdyinasyingie
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1725-1762 8.3e-07 23.3 In-house 77-114 (288) alignment 
Range on Protein: 1725-1762
Range on HMM: 77-114/288.0
GYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC
  . |. .| ||.|.. |   .|||...  |  |||||
sakykrrlicaqaPlngtieelWkmllesdveyivmlc
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1704-1761 9.1e-07 22.6 In-house 49-107 (332) alignment 
Range on Protein: 1704-1761
Range on HMM: 49-107/332.0
AGEDLAKNQGSNSYTNPSFTAGYHDKKAFIIAQSPMEN-TARDFWKMIVDYKVSAIVML
.  .|| ..| . . | |.  ||  | |.|.||.|... |   ||.|. . | | |...
srvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1805-1913 9.9e-07 22.8 In-house 216-348 (350) alignment 
Range on Protein: 1805-1913
Range on HMM: 216-348/350.0
NVLQLQVTDWPQDGVVREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQ------C---------KAEgVVD-VFQ
 |.||||  |.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....   |..                 |. . | ...
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDlisi

VTKAVRKSKPGAVTTLEQYTSIYDVIDMYLQMNK
. . .|| .   | .|.|.  ||. .  | ...|
ivnelrkqrismvqnldqfifiYeallfyfaLrk
subfamily_CG42327_pd Subfamily CG42327 1712-1778 2.3e-06 21.5 In-house 53-124 (319) alignment 
Range on Protein: 1712-1778
Range on HMM: 53-124/319.0
QGSNSYTNPSFTAGYHDKKA-FIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE-D---CCYPYWTGLSTH
. .. | . |.  ||.| .. .| || ..|... |||... . .   || |.         |  |.    | 
ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1710-1761 2.4e-06 21.3 In-house 65-116 (347) alignment 
Range on Protein: 1710-1761
Range on HMM: 65-116/347.0
KNQGSNSYTNPSFTAGYHDKKAFIIAQSPMENTARDFWKMIVDYKVSAIVML
. . ...| | |       .| .|..| |. .| ||||||.   ||. .| .
raddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1715-1774 2.6e-06 21.2 In-house 69-134 (303) alignment 
Range on Protein: 1715-1774
Range on HMM: 69-134/303.0
NSYTNPSFTAGYHDKKAfIIAQSPMENTARDFWKMIVDYKVSAIVMLCGEE-------DCCYPYWTG
 ||   |.     .||| |..| |.  || |||.||.. ||  ...|  .        |  .|    
ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1804-1911 6.7e-06 19.6 In-house 218-346 (349) alignment 
Range on Protein: 1804-1911
Range on HMM: 218-346/349.0
RNVLQLQVTDWPQDGVVREPRTVLQV-------IDDVIHRQ--QKIGGGPVVVHCSDTVSRSGVYCSVSIGLE--QCKAEGV--V--------DVFQVTK
  .||||| .|.  ... .| ..||        |||   |.  ..    ...||||    |.||.. . . |.  .   .    .         .. .  
yellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

AVRKSKPGAVTTLEQYTSIYDVIDMYLQM
 .|| .   |  | |.  ||. .  |...
elrkqrismvqnlaqfiaiyealLkyfal
subfamily_ptpA1_pd Subfamily ptpA1 1795-1866 7e-06 20.0 In-house 177-253 (418) alignment 
Range on Protein: 1795-1866
Range on HMM: 177-253/418.0
IERMLNVESRNVLQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIGL
|   .. |.|.. | |   ||.  .    . . |..  .  ||..|        |..||||  | |.| .|.  | .
irltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
APH Phosphotransferase enzyme family 670-724 7.5e-06 14.4 Pfam-A 144-197 (239) alignment 
Range on Protein: 670-724
Range on HMM: 144-197/239.0
DRFEMYK-IIDICRQTAQGvdyLHAKQIIHRDLKSNNIFLHDDMTVK-IGDFGLATV
...|. . ... . ..  |     .....|.||...|.....| ..  . ||..|..
lleeleervlaalaallpg...aeppvllHgDlhpgNllvdpddgrvgviDfedagl