Gene PTPRD-68 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP126_AA protein Get Run
AqueP126_AA_456-559 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 460-566 4.4e-68 224.2 In-house 195-301 (301) alignment 
Range on Protein: 460-566
Range on HMM: 195-301/301.0
TVKGMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLA
 .. ..|||.|.||||||||||||||||||||||.||||||||||.||||..||.||||||||||||||||||..|||||||||||||..||....|||.
vtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

INSTYSN
.||||.|
lnstyan
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 465-561 1.4e-36 121.2 In-house 190-286 (305) alignment 
Range on Protein: 465-561
Range on HMM: 190-286/305.0
NDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAIN
..|| . . ..|..|..| ..|.|  | |..||||..|.||||..|..||||..|.|.|||||.|.|.|.......|.||.||  ...||. ..   
dhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 465-565 7.4e-32 105.4 In-house 190-290 (290) alignment 
Range on Protein: 465-565
Range on HMM: 190-290/290.0
NDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINSTY
..| . .| |.|.||  ... | | | ..|||||||||.|..|.||. .....|| |||.||||| | ..  ||| |.| .|| .|.. .  ||   .||
stgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

S
|
s
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 466-567 4.1e-30 99.7 In-house 186-287 (287) alignment 
Range on Protein: 466-567
Range on HMM: 186-287/287.0
DGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINSTYS
 | . .|.|.| ||.. .. |.| | ..||||||||| |....||. .....|| |||.||||| |  .  |||.| | |||. |.... .||   .|||
tgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

NF
.|
df
subfamily_PTPRD_pd Subfamily PTPRD 466-564 2e-27 91.1 In-house 190-287 (564) alignment 
Range on Protein: 466-564
Range on HMM: 190-287/564.0
DGVLRDPRTVLQVIDDVIHRQqKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINSTY
 ||   ....|..|..| . . . . ||||||||  | |||....|.. ||. |.|..||..|. |||.. ..  | | |||| |.||.  .||  .| 
hgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 470-565 2.4e-27 90.7 In-house 154-249 (250) alignment 
Range on Protein: 470-565
Range on HMM: 154-249/250.0
RDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINSTYS
.  ..||.....|   ||..| .|..|.||  |.|.| ..||.  ||. | | |||||.| |.|.. .|.||..||||. .||... .|   . |.
evatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 466-564 3.3e-27 90.5 In-house 198-296 (298) alignment 
Range on Protein: 466-564
Range on HMM: 198-296/298.0
DGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINSTY
 || .  ..||.....|   ||. |  |..|.||. | |.| ..||.  ||. |.| ||||||| |.|....||||.| |||. ||||   .|.  ...
kgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 465-563 1.3e-26 88.5 In-house 190-288 (319) alignment 
Range on Protein: 465-563
Range on HMM: 190-288/319.0
NDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINST
...| .. ...|... .. . ..|   ||||||||. | ||| .......||. | |||.|||.. . |.  ..  | . |||. |||||  .. . .|
dhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 465-565 8e-26 85.8 In-house 187-287 (318) alignment 
Range on Protein: 465-565
Range on HMM: 187-287/318.0
NDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINSTY
. ||. .. ..|... .| . ||| | ||||||||  | ||||..|..| ||. |||..|||||. | |.. ..  | | .||. ||..|. .||   |.
degvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte

S
 
v
0046845 (Phosphotyrosine protein) phosphatases II 465-566 1.2e-24 82.6 In-house 177-282 (284) alignment 
Range on Protein: 465-566
Range on HMM: 177-282/284.0
NDGVLRDPRTVLQVIDDVIHRQQK-IGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEG---VVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAI
..||  .|. .|. ...| . ...  ||||||||||. |.|||...|. ..||| ..||   .|||... | |.. .||.|.|||||. .|||| .||  
dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

NSTYSN
  |. .
kltlle
0050432 (Phosphotyrosine protein) phosphatases II 465-564 1.3e-24 82.5 In-house 209-305 (308) alignment 
Range on Protein: 465-564
Range on HMM: 209-305/308.0
NDGVLRDPRTVLQVIDDVIHRQqkiGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINSTY
..||  .|. .|. .. | ...   .|||||||||. |.|||...|. ..||| ..|| ||||.. | |.. .||.|.|.|||. .|.|| .||    |.
dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
0051299 (Phosphotyrosine protein) phosphatases II 457-558 4e-24 81.0 In-house 165-286 (288) alignment 
Range on Protein: 457-558
Range on HMM: 165-286/288.0
RILTVKGM---------------------NDGVLRDPRTVLQVIDDVIHRQQkIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKR
| |.|. .                     ..||  .|. .|. . .|.. ..  ||||.|||||. |.|||...|. ..||| ..||.|||... | |..
rtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlre

SKPGAVTTLEQYITIYEALKMYL
 .||.|.|.|||. .|||| .||
qRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 465-563 5.2e-24 80.5 In-house 180-282 (297) alignment 
Range on Protein: 465-563
Range on HMM: 180-282/297.0
NDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCK---AEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAI
 .||  .|...|. |. | ...... .|||..||||. |.|.|...|. ..|.| .    || ||.... | |.. .||||.|||||. .|||| ..|  
dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk

NST
. |
klt
0040438 (Phosphotyrosine protein) phosphatases II 457-564 4.6e-23 77.4 In-house 159-282 (317) alignment 
Range on Protein: 457-564
Range on HMM: 159-282/317.0
RILTVKG-----------------MNDGVLRDPRTVLQVIDDVIHRQQkiG-GGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKP
| |.|..                   .||  .|...|. .. | . ..  . |||..||||. |.|||...|. ..|||.. || |||... | |.. .|
rtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRp

GAVTTLEQYITIYEALKMYLAINSTY
|||.|.|||. .|.|| .||  . |.
gavqtpeqyrflydalleylkrkltl
0039614 (Phosphotyrosine protein) phosphatases II 465-561 5.5e-23 77.3 In-house 195-292 (297) alignment 
Range on Protein: 465-561
Range on HMM: 195-292/297.0
NDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAIN
 .||  .....|.... | .....  .|||..||||. |.|||...|. ..|||.. || |||... | |.. .||||.|..||. .|.||...|  .
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0047943 (Phosphotyrosine protein) phosphatases II 465-558 6.3e-23 77.0 In-house 178-272 (273) alignment 
Range on Protein: 465-558
Range on HMM: 178-272/273.0
NDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
..||  ..  .|. |..| . .... ..||.|||||. |.|||...|. ..|.| ..|| |||... | |.. .||.|.|.|||. .|||| .||
dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 467-558 9.7e-23 75.5 In-house 205-295 (330) alignment 
Range on Protein: 467-558
Range on HMM: 205-295/330.0
GVLRDPRTVLQVIDDVIHRQQKIGGgPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
||  .|. .|...  | . .|. .| |||||||  | ||| .....  ||. |||..||||.. | |.  .|  | |.|||  ||..|. | 
GvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
0045450 (Phosphotyrosine protein) phosphatases II 462-558 1.9e-22 75.8 In-house 186-304 (307) alignment 
Range on Protein: 462-558
Range on HMM: 186-304/307.0
KG------------------MNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPG
.                    ..||  .. ..|. |. | . ...  .|||..||||. |.|||...|. ..|.| ..||.   ||.... | |.. .||
tdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpg

AVTTLEQYITIYEALKMYL
||...|||. .||||...|
avqnpeqyrflyeallell
DSPc_SM00195 467-558 3.1e-22 74.5 In-house 172-262 (263) alignment 
Range on Protein: 467-558
Range on HMM: 172-262/263.0
GVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
||  ... ||...  | ......  ||||||||. |.|||....|.|.|.....|  ||.|.. |.|. ..||.|.|||||..||||.  |.
gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 467-558 3.1e-22 74.5 In-house 172-262 (263) alignment 
Range on Protein: 467-558
Range on HMM: 172-262/263.0
GVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
||  ... ||...  | ......  ||||||||. |.|||....|.|.|.....|  ||.|.. |.|. ..||.|.|||||..||||.  |.
gvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 465-558 3.9e-22 74.5 In-house 185-277 (278) alignment 
Range on Protein: 465-558
Range on HMM: 185-277/278.0
NDGVLRDPRTVLQVIDDVIHRQQkIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
 .||  .. ..|. . .|.....   .||..||||. |.|||...|. ..||| . || ||.... | |.. .||||.|..||. .||||..||
dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 464-554 5.6e-22 73.7 Pfam-A 143-233 (235) alignment 
Range on Protein: 464-554
Range on HMM: 143-233/235.0
MN-DGVLRDPRTVLQVIDDVIHRQqKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
 .  || ..|. .|..|..| ... .   ||.|||||. |.|||...|..|.|||..||. |||.|. | |....||.|..||||| .|.|.
Wpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 464-554 5.6e-22 73.7 In-house 143-233 (235) alignment 
Range on Protein: 464-554
Range on HMM: 143-233/235.0
MN-DGVLRDPRTVLQVIDDVIHRQqKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
 .  || ..|. .|..|..| ... .   ||.|||||. |.|||...|..|.|||..||. |||.|. | |....||.|..||||| .|.|.
Wpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0040439 (Phosphotyrosine protein) phosphatases II 465-558 1e-21 73.2 In-house 152-246 (249) alignment 
Range on Protein: 465-558
Range on HMM: 152-246/249.0
NDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
 .||  .. ..|. |. | . ....  |||..||||. |.|||...|. ..||| . |. ||.... | |.. .||||...|||. .||||...|
dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
PTPc_DSPc_SM00012 467-555 1.4e-21 72.0 In-house 14-104 (105) alignment 
Range on Protein: 467-555
Range on HMM: 14-104/105.0
GVLRDPRTVLQVIDDVIHRQQKIG-GGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRSKPGAVTTLEQYITIYEALK
|| ...  .|.....| . ..|.. ..|.|||||. |.|||...|..|.|.|...| . ||.||. |.|....||.|.|.|||. .|.||.
gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyrall
0042113 (Phosphotyrosine protein) phosphatases II 466-558 3.6e-21 71.1 In-house 151-243 (245) alignment 
Range on Protein: 466-558
Range on HMM: 151-243/245.0
DGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
.||  .....|.... | . ... ..||..||||. |.|||...|. ..||| ..|. |..... | |.. .||||.|..||. .||||...|
hgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPRK_pd Subfamily PTPRK 471-554 5.7e-21 69.6 In-house 191-273 (314) alignment 
Range on Protein: 471-554
Range on HMM: 191-273/314.0
DPRTVLQVIDDVIHRQQKiGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
  ...|...  | . |.. . |.||||||    |||...||.| |.  . |||||||.. |.|. .|.  | | |||. ||...
satgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Ptp69D_pd Subfamily Ptp69D 471-561 1.6e-20 68.5 In-house 200-289 (307) alignment 
Range on Protein: 471-561
Range on HMM: 200-289/307.0
DPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAIN
 .|..|..|. | . ...   .|||||||  |.|.|.. |... |.|.|||  ||.|...| |.. ..  |. ||||. .| ||  |    
vargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_CG7180_pd Subfamily CG7180 488-562 2.6e-20 67.3 In-house 220-294 (296) alignment 
Range on Protein: 488-562
Range on HMM: 220-294/296.0
KIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINS
.   ||.||..|| .||.|||.|| ..||. . |. ||||.  | |.||.|. | . |.|  ||. |. ..  | 
dpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 479-554 1.9e-19 64.6 In-house 187-262 (283) alignment 
Range on Protein: 479-554
Range on HMM: 187-262/283.0
IDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
.. ||  |..   |||||||| .. ||.|..|.| .... ..| |||||.| | ..  ...|| ||.||  ..|. 
fnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0045098 (Phosphotyrosine protein) phosphatases II 467-559 5.7e-19 64.0 In-house 168-273 (278) alignment 
Range on Protein: 467-559
Range on HMM: 168-273/278.0
GVLRDP--RTVLQVIDDVIHRQQK------------IGGGPIVVHCSDTVSRTGVYCAISIALEQCkaEGVVDVFQVTKALKRSKPG-AVTTLEQYITIY
||  .|  . .|.... . .....             .|||..||||  |.|||...|. . ||..  ||.||.... | |.. .|| ||..||||. .|
gvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrfly

EALKMYLA
|.| ..| 
efllelll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 469-558 7.1e-19 62.9 In-house 177-268 (274) alignment 
Range on Protein: 469-558
Range on HMM: 177-268/274.0
LRDPRTVLQVIDDVIHRQQKI--GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
 .|..|.|.....| . ...     .|.|||||  . |||.. |||||. | ..|.||||....  |.  . | | | |||  |..|| .||
PddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_PTPN6_pd Subfamily PTPN6 466-564 8.2e-19 62.7 In-house 199-303 (306) alignment 
Range on Protein: 466-564
Range on HMM: 199-303/306.0
DGVLRDPRTVLQVIDDVIHRQQKIG---GGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLA
 || .|| .||. ..|| ..|...     ||||||||. . ||| .  | | |.. . .|.   .|. .. | ... . | | | .||  .|.|.|.|. 
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

INSTY
 ....
tkkkl
subfamily_PTPRG_pd Subfamily PTPRG 487-559 8.7e-19 62.1 In-house 216-288 (563) alignment 
Range on Protein: 487-559
Range on HMM: 216-288/563.0
QKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLA
.|   ||||||||  |.|||.|....  |.| ..| .|.||.. | ..  ..  |.| |||| ...||   .|
nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
0037934 (Phosphotyrosine protein) phosphatases II 466-557 3e-18 61.7 In-house 146-241 (243) alignment 
Range on Protein: 466-557
Range on HMM: 146-241/243.0
DGVLRDPRTVLQVIDDVIHRQQK-------IGGGPIVVHCSDTVSRTGVYCAISIALEQCkaeGvVDVFQVTKALKRSKPG-AVTTLEQYITIYEALKMY
 ||  .|  .|. .|.|.  ...        .|||..||||  |.|||...|. . |...   | ||.... | |.. .|| ||.|..||. .||||...
hgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 462-558 5.5e-18 60.2 In-house 186-288 (325) alignment 
Range on Protein: 462-558
Range on HMM: 186-288/325.0
KGMN-DGVLRDPRTVLQV---IDDVIHRQQK--IGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALK
.. .  || . | |.. .   .. |  | .    . .||.||||. | ||||. ..  ||..   |  ||.|.. | |.. .|  | | .||| ||||| 
qswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv

MYL
 ..
eay
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 473-563 2.4e-17 58.0 In-house 199-289 (297) alignment 
Range on Protein: 473-563
Range on HMM: 199-289/297.0
RTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINST
...|..|..| .  ..   ||..|||.  | ||||...|   . . | |  ||.|.. | |....|  | | |||  .|.|.  .|  . |
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 484-555 5.5e-17 56.7 In-house 207-276 (315) alignment 
Range on Protein: 484-555
Range on HMM: 207-276/315.0
HRQQKIggGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALK
|.....  |.||||||. | ||| .....  |.| .|| ..||... . ... . ..| ..|||  ||.|| 
hhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 465-562 1.5e-16 55.1 In-house 185-281 (315) alignment 
Range on Protein: 465-562
Range on HMM: 185-281/315.0
NDGVLRDPRTVLQVIDDVIHRqQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINS
. || ..  ..|..| .|    ..    ...||||  | |||| ..|   ..| | . .||||.. | |.. .|  | | |.|  ||.|.. .|    
dkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 466-562 2.8e-16 53.7 In-house 185-280 (515) alignment 
Range on Protein: 466-562
Range on HMM: 185-280/515.0
DGVLRDPRTVLQVIDDVIHRQQKIGgGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINS
 || .. ...|..| .|   ....   |...|||  | ||||...|   . . |   .||||.. . ... .|  | | |||  ||.|.. .|    
kGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrn
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 464-555 3.4e-16 54.1 In-house 186-276 (288) alignment 
Range on Protein: 464-555
Range on HMM: 186-276/288.0
MNDGVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALK
 ..|| .. . .|.... |   .|.   |||.||||. | |||.. |.  .... ..| ..||. . . |.....  | ||.||. |||.| 
pdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 484-557 3.5e-16 54.0 In-house 185-258 (267) alignment 
Range on Protein: 484-557
Range on HMM: 185-258/267.0
HRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMY
. | . |. |.||.||| | |.| .  |   ||. | |||.|.|.  . ..  ..| | |.|.|| |.| |  |
knqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_PTPRB_pd Subfamily PTPRB 467-558 6.1e-16 53.3 In-house 193-285 (293) alignment 
Range on Protein: 467-558
Range on HMM: 193-285/293.0
GVLRDPRTVLQVIDDVIHRQ-QKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
||  ...|.|. .  | ... ..   .|||||||  | |||.. |.   |.. . | .||.| .  .|....   | | .||| |....  .|
gvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0051429 (Phosphotyrosine protein) phosphatases II 465-559 6.3e-16 54.3 In-house 132-226 (272) alignment 
Range on Protein: 465-559
Range on HMM: 132-226/272.0
NDGVLRDPrtVLQVIDDVIHrqqkigGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVD--------VFQVTKALKRSKPGAVTTLEQYITIYEALKM
 .|| ...  .|.... . .      |||..||||  ..|||...|. . |..  .| .||        .... . |..  |||| | |||. .||||. 
dhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyealle

YLA
.| 
llr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 467-554 8.4e-16 53.2 In-house 199-287 (319) alignment 
Range on Protein: 467-554
Range on HMM: 199-287/319.0
GVLRDPRTVLQVIDDVIHRQQKIGG-GPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
||   |  ...... | | ..|  .  .||||||  | ||||| .. . |.. | |  |||... . |.. ..  |  | ||  || ||
GvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
0036282 (Phosphotyrosine protein) phosphatases II 465-552 1.2e-15 53.1 In-house 78-164 (174) alignment 
Range on Protein: 465-552
Range on HMM: 78-164/174.0
NDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKaEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
 |.   |  ..|.... | . ... .|||..||||  |.|||. .|. . | . . |..||.... ..|.. .||.|.| .||. .|.
pDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 466-555 1.2e-15 52.8 In-house 162-252 (284) alignment 
Range on Protein: 466-555
Range on HMM: 162-252/284.0
DGVLRDPRTVLQVIDDVIHRQQKIGG-GPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALK
 ||   |  ...... | | ..|  .  .||||||  | ||||| .. . |.. | |  |||... . |.. ..  |  | ||  || || 
vgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 469-559 1.5e-15 51.9 In-house 174-265 (270) alignment 
Range on Protein: 469-559
Range on HMM: 174-265/270.0
LRDPRTVLQVIDDV-IHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLA
  ... .|... .|  .....  ..|..||||. | |||.  |. ||..  . .. ||| .. ..|.. ..  | . |||  .|.|. .|  
slstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_PTPN12_pd Subfamily PTPN12 467-557 1.6e-15 51.7 In-house 184-276 (290) alignment 
Range on Protein: 467-557
Range on HMM: 184-276/290.0
GVLRDPRTVLQVIDDVIHRQQkIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPGAVTTLEQYITIYEALKMY
|| . . ..|..|..| ..|.     |.|||||  | |||. .|| .. |. ||| .   .|||..   |.. .. .| | |||  .|.|.  .
gvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
0041856 (Phosphotyrosine protein) phosphatases II 465-561 1.2e-14 49.8 In-house 88-174 (182) alignment 
Range on Protein: 465-561
Range on HMM: 88-174/182.0
NDGVLRDPRTVLQVIDDVIHrqqkiGGGPIVVHCSDTVSRTGVYCAISIALEQckaeGvVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAIN
 |.   |....|. |..|..      |||..||||  |.|||...|. . ...    | |..... | ... .||.|.|..||. .. || ..|  .
pDhgvpdldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 467-558 1.2e-14 48.5 In-house 103-194 (440) alignment 
Range on Protein: 467-558
Range on HMM: 103-194/440.0
GVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
|| .    ||..|.|| . |.| | ||..||||  ..||||  |.   | ..|    .|.| . .... ..|  | | |||  ..||.   |
gvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegl
0043147 (Phosphotyrosine protein) phosphatases II 466-557 6.4e-14 47.5 In-house 76-160 (172) alignment 
Range on Protein: 466-557
Range on HMM: 76-160/172.0
DGVLrDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALeqckaeG-VvDVFQVTKALKRSKPGAVTTLEQYITIYEALKMY
 ||  ... .|.... . .....  |||..||||  |.|||. .|. . |        . ..... . ... .||||.. .||. .|.  |..
hgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 484-555 6.6e-14 46.2 In-house 205-276 (439) alignment 
Range on Protein: 484-555
Range on HMM: 205-276/439.0
HRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALK
  ..|   ||.|||||  | |||   |. ||||| |.|  ||.  . | |.. .   | .| ||. ||.|. 
sandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_PTPN13_pd Subfamily PTPN13 466-556 1.4e-13 45.8 In-house 179-267 (273) alignment 
Range on Protein: 466-556
Range on HMM: 179-267/273.0
DGVLRDPRTVLQVIDDVIHRQQkiGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKM
 || . .  .||..  | . |.    ||||||||  . |.|.. .| ..|.  . .  .|| .. . |.. . | | | .||| .|.|.  
hgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
0049260 (Phosphotyrosine protein) phosphatases II 463-552 2e-13 45.8 In-house 61-144 (152) alignment 
Range on Protein: 463-552
Range on HMM: 61-144/152.0
GMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALeqckaeGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
 . |.   |   .|. . ..|.. ..  |||..||||  |.|||...|. . |        |..... . ... .||||.. .|.. .||
pwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_CG42327_pd Subfamily CG42327 490-558 4e-13 43.7 In-house 246-315 (319) alignment 
Range on Protein: 490-558
Range on HMM: 246-315/319.0
GGGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
  ||.|||||| | |||.  |  ||... .     ||. |.   ..| .  || | |||  ||  | .| 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
0046846 (Phosphotyrosine protein) phosphatases II 465-558 4.3e-13 44.9 In-house 85-173 (176) alignment 
Range on Protein: 465-558
Range on HMM: 85-173/176.0
NDGVLRDPRTVLQVIDDVIHRQQKigGGPIVVHCSDTVSRTGVYCAISialeQCKAEGVVDVFQVTKALKRSKP-GAVTTLEQYITIYEALKMYL
 |.   | . .|.... .  ....  |||..||||  ..|||...|.      .. |  ..|... . ... .| |||.| |||  .||.....|
pDhgvpdlelllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_PTPN9_pd Subfamily PTPN9 486-557 4.8e-13 43.8 In-house 218-289 (297) alignment 
Range on Protein: 486-557
Range on HMM: 218-289/297.0
QQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMY
. .. | |||||||  . ||| .... |.|.. . .|.|||... | |.  .  .. | |||   | |.  |
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 465-559 8.3e-13 43.1 In-house 182-277 (281) alignment 
Range on Protein: 465-559
Range on HMM: 182-277/281.0
NDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLA
. ||  ... .|.  ..| . ..|    |.|.|||  | |||.| |.  ......||   .|| .| . |....   | |. ||  .| |.. .| 
dhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 481-553 1e-12 42.7 In-house 163-235 (239) alignment 
Range on Protein: 481-553
Range on HMM: 163-235/239.0
DVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
  | ..   |  | |.|||  | ||| .  |   | |.| .  ||.|.  ||..  .|  | | |||. |. |
rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 481-553 1.1e-12 42.7 In-house 164-236 (239) alignment 
Range on Protein: 481-553
Range on HMM: 164-236/239.0
DVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
  | ..   |  | |.|||  | ||| .  |   | |.| .  ||.|.  ||..  .|  | | |||. |. |
rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
0049772 (Phosphotyrosine protein) phosphatases II 464-559 2.1e-12 42.9 In-house 188-281 (314) alignment 
Range on Protein: 464-559
Range on HMM: 188-281/314.0
MNDGVLRDPRTVLQVIdDVIHRQqkIGGGPIVVHCSDTVSRTGVYCAISIALEQCkaeGVvDVFQVTKALKRSKP-----GAVTTLEQYITIYEALKMYL
. ||   ... ..... ..|..     |||..|||.. ..|||..... . . ..   || .. .. . ...  |     |.. .||||. |.|||..||
vpDgsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl

A
 
k
fn3 Fibronectin type III domain 138-211 2.2e-12 40.2 Pfam-A 2-78 (85) alignment 
Range on Protein: 138-211
Range on HMM: 2-78/85.0
APSSLTEVSKTATTITVSWTALD--SSDADGYVVNVTSDTDT--VQTVQVEGSSNnTITLNGLRELTTYNITVRTYQQ
||. |.  . |.|..|.||.. .  ... .|| | . .....   ....|..... . ||.||.. |.|...|... .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavng
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 467-553 2.7e-12 41.4 In-house 147-234 (237) alignment 
Range on Protein: 467-553
Range on HMM: 147-234/237.0
GVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
|| .   ..|.   ..|.| ...   || ..|||  | |||..  |   | |.| . |||...  ....  .|  . | .||. |...
gvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt
0048076 (Phosphotyrosine protein) phosphatases II 466-557 4.4e-12 41.4 In-house 58-142 (145) alignment 
Range on Protein: 466-557
Range on HMM: 58-142/145.0
DGVLRDPRTVLQVIDDVIHRQQKigGGPIVVHCSDTVSRTGVYCAISIALEqckaEGvVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMY
 ||  .....|.... . . ...  |||..||||  |.|||...|. . |.    .| |..... . ...  ||||.. .|.. .||.....
hgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefelel
0051082 (Phosphotyrosine protein) phosphatases II 467-553 5.8e-12 41.0 In-house 68-148 (151) alignment 
Range on Protein: 467-553
Range on HMM: 68-148/151.0
GVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQckaegvVDVFQVTKALKRSKPGAVTTLEQYITIYEA
    .  . .. . ....  .. ..||..||||  ..|||. .|. . |..      |..... . .... ||.|.. .|.. .. |
wpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_PTPN23_pd Subfamily PTPN23 466-554 2e-11 38.3 In-house 183-276 (288) alignment 
Range on Protein: 466-554
Range on HMM: 183-276/288.0
D-GVLRDPRTVLQVIDDVIH---RQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQC-KAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. ||   | |.||..| | .    .|.    |.|||||  | ||||.. .  |...  | .|..|. || . |.. .   | . ||.   ||| 
elGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 470-556 3.9e-11 37.0 In-house 149-234 (392) alignment 
Range on Protein: 470-556
Range on HMM: 149-234/392.0
RDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKM
.   ..|..| .|     .    |...|||  | ||||  .|   . ..|   .||||..   ..| .|  | | |||  || |.  
khtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
0044763 (Phosphotyrosine protein) phosphatases II 464-561 4.7e-11 38.1 In-house 83-174 (178) alignment 
Range on Protein: 464-561
Range on HMM: 83-174/178.0
MNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQckaeGVvDVFQVTKALKRSKPgAVTTLEQYITIYEALKMYLAIN
. |.   | .  .. . . |.. ..  |||..||||  |.|.|. .|. . ...    |. ..... . ... .| .|.. .|.  .||  ...|. .
ipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrllkes
0048179 (Phosphotyrosine protein) phosphatases II 467-552 5.3e-11 38.0 In-house 61-139 (144) alignment 
Range on Protein: 467-552
Range on HMM: 61-139/144.0
GVLRDPRTVLQVIDDVIHRQQkiGGGPIVVHCSDTVSRTGVYCAISIALeqckAEGvVDVFQVTKALKRSKPGAVTTLEQYITIYE
||  ..  .|.... . . ..   |||..||||  |.|||...|. . .     .| ...... . ...  ||||.. .|.. ..|
gvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPN3_pd Subfamily PTPN3 465-554 2.2e-10 34.9 In-house 183-271 (280) alignment 
Range on Protein: 465-554
Range on HMM: 183-271/280.0
NDGVLRDPRTVLQVIDDViHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. ||  |.  .|.... | .....    |.|||||  . ||||. .. .||    |.  | . .. . ..  .   | | .||  . ||.
dhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 473-562 2.2e-10 34.8 In-house 192-281 (287) alignment 
Range on Protein: 473-562
Range on HMM: 192-281/287.0
RTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAINS
| ||.| . .  ...  . ||.|||..  . |.|.. |. . ... .  | ||| .|   |.  . . | .  |.  .||||  |   | 
rfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnp
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 494-555 3.4e-10 34.2 In-house 1-62 (69) alignment 
Range on Protein: 494-555
Range on HMM: 1-62/69.0
IVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALK
.|||||    ||| . || . . . |.| .||.|   . ... .|  |    .|| |..|| 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 491-552 3.9e-10 34.2 In-house 135-198 (199) alignment 
Range on Protein: 491-552
Range on HMM: 135-198/199.0
GGPIVVHCSDTVSRTGVYCAISIALE---QCKaEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
  |..|||||    |||. |. | .    . |   |||.|.|.| |.... | ...|..|  ||.
dapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 491-552 3.9e-10 34.2 In-house 134-197 (198) alignment 
Range on Protein: 491-552
Range on HMM: 134-197/198.0
GGPIVVHCSDTVSRTGVYCAISIALE---QCKaEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
  |..|||||    |||. |. | .    . |   |||.|.|.| |.... | ...|..|  ||.
dapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_PTPN14_pd Subfamily PTPN14 490-558 4.6e-10 34.0 In-house 228-296 (300) alignment 
Range on Protein: 490-558
Range on HMM: 228-296/300.0
GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
   |..||||. | ||||     . ..  . . ..|. .| . |.. .   | || ||  .|..|  ||
skPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 490-556 9.9e-10 32.5 In-house 215-281 (290) alignment 
Range on Protein: 490-556
Range on HMM: 215-281/290.0
GGGPIVVHCSDTVSRTGVYCAISIALeQCKAEG-VVDVFQVTKALKRSKPGAVTTLEQYITIYEALKM
  ||.|||||  . ||| . || ..| |.  .|  .|. .. .||..|. ..|    ||... |.|  
asGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 495-555 2e-09 31.7 In-house 1-61 (69) alignment 
Range on Protein: 495-555
Range on HMM: 1-61/69.0
VVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALK
|||||    ||| . || . . . |.| .||.|   . ... .|  |   ..|. |..|| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_PTPRN_pd Subfamily PTPRN 490-553 1.5e-08 28.7 In-house 223-287 (297) alignment 
Range on Protein: 490-553
Range on HMM: 223-287/297.0
GGGPIVVHCSDTVSRTGVYCAISIALEQC-KAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
   |||||||| . |||||..| . |..  |    .|.    . |.  .|| | | .|.  .. |
rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 469-561 7.2e-08 26.5 In-house 231-347 (350) alignment 
Range on Protein: 469-561
Range on HMM: 231-347/350.0
LRDPRTVLQVID-------DVIHR--QQKIGGGPIVVHCSDTVSRTGVYCAISIALE------Q---------CKAEgVVD-VFQVTKALKRSKPGAVTT
| .|. .||...       | . .   ..  . ||.||||  | |||.....   |.      .           |. . | .... . |.. .   | .
llnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDlisiivnelrkqrismvqn

LEQYITIYEALKMYLAIN
|.|.| |||||. | |..
ldqfifiYeallfyfaLr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 492-561 7.7e-08 26.7 In-house 205-274 (288) alignment 
Range on Protein: 492-561
Range on HMM: 205-274/288.0
GPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAIN
 |||||.|  | |||    | ||||. . .  . . .. . |. ..  |..|  ||. ..  .. .|.. 
kPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 494-549 2.3e-07 24.5 In-house 224-279 (302) alignment 
Range on Protein: 494-549
Range on HMM: 224-279/302.0
IVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYIT
..||||  | |||   ||   .. |. . | |. .. . ... . ||| . .| | 
vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 483-555 4.8e-07 23.7 In-house 192-266 (281) alignment 
Range on Protein: 483-555
Range on HMM: 192-266/281.0
IHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRS-KPGAVTTLEQYITIYEALK
| |. .    | |.|||  | |.|   |. |||.  ..   . |. |.   |. . .  .| ||.||. |.. | 
ilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 493-554 4.8e-07 23.9 In-house 230-291 (297) alignment 
Range on Protein: 493-554
Range on HMM: 230-291/297.0
PIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
...||||  | |.||     . |.. . . . ||  . . |.  ..  | ||||.  .|.| 
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 489-553 1.1e-06 22.4 In-house 221-285 (310) alignment 
Range on Protein: 489-553
Range on HMM: 221-285/310.0
IGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
.  || |||||  . |..| .|. ..... .    ||. .|   |..|.   . |  ||. |   
vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 491-558 1.5e-06 22.5 In-house 209-277 (307) alignment 
Range on Protein: 491-558
Range on HMM: 209-277/307.0
GGPIVVHCSDTVSRTGVYCAISIALEQC-KAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYL
  |.|||||  | |.|   |||.  ..  . .   |. .. . |.  .. |. |  ||. ..  |  |.
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 468-554 1.9e-06 22.3 In-house 173-255 (290) alignment 
Range on Protein: 468-554
Range on HMM: 173-255/290.0
VLRDPRTVLQVIDDVIhrqqkIGGGPIVVHCSDTVSRTGVYCAISIALEQCK-AEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
| .|..|.|..|. |        . |..||| | .||  .  || ..       .| | . .| |||.. .  |.|. ...  .  ..
vqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi
subfamily_PTPN1_pd Subfamily PTPN1 491-553 2.1e-06 21.7 In-house 201-266 (290) alignment 
Range on Protein: 491-553
Range on HMM: 201-266/290.0
GGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPGAVTTLEQYITIYEA
 || |.|||  . |.| .| .   | . ....    ||. .|  .|.. . | . | .|    | |
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyla
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 478-561 5e-06 20.1 In-house 250-347 (349) alignment 
Range on Protein: 478-561
Range on HMM: 250-347/349.0
VIDDVIHRQ--QKIGGGPIVVHCSDTVSRTGVYCAISIALE--QCKAEG--VV--------DVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLAIN
.|||   |.  ..    ...||||    ||||.. . . |.  .   .    .         .. .   |.. .   |  | |.|.|||||  |.|..
liddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 489-559 6.5e-06 19.8 In-house 216-286 (302) alignment 
Range on Protein: 489-559
Range on HMM: 216-286/302.0
IGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALKMYLA
 .  ..|.     . | |.  .  .|.|. ...  . . .. |...  .| || .|.||...| || .|. 
kadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik