Gene PTPRD-62 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP127_AA protein Get Run
AqueP127_AA_1270-1594 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1270-1486 1.3e-79 262.1 In-house 2-235 (301) alignment 
Range on Protein: 1270-1486
Range on HMM: 2-235/301.0
LNDLGNHVACCHSDSnayFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLP---GVAQHEYINASYIHGYSKARKFIAAQGPMKKTL
|.|||.|||..||..   |.||.|.|..|.||.|.|||. .||.||||.||..|||| |.||      ..|.||||||||.|||...|||||||||||||
ledlgthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktl

VDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSG--------------EVHALTQYHLTTW
||||.|||||||.|.||.||| |..|.|||||||.. .| |.||||.||| ...|.||.|||...|..||||.              . . ..|...| |
vdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdW

PDHGV-PEYATPLMTLHKRVMSS--SAKGPILVHCSA
|..|| .|..| |. ... ..      .||..||||.
pqdGvvreprtvLqviddvihrqqkigggpvvVHCSd
subfamily_PTPRD_pd Subfamily PTPRD 1267-1487 6.4e-74 244.6 In-house 4-224 (564) alignment 
Range on Protein: 1267-1487
Range on HMM: 4-224/564.0
PISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKT
||. ..| .|||  ...|.. |.|..|.. .|.  ....  . .||. ||. |||.|| . . | |..|. . .|||||.|.|| | ...||.|||...|
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaet

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClNeIEQFGPFSVTLLEDYVMPDYVIRNISVtLQDGSGEVHALTQYHLTTWPDHGVPEYATPLM
. ||| ..|... ...||||.|.| .|.||..|||.  .  |..| . ||| | . . ||.||....  .  | |..  .|.| | ||||||||.||.|.
iedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslL

TLHKRVMSS--SAKGPILVHCSAG
.| ..| ..  . .|||.||||||
dlirkvralnepdagPivVhCSaG
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1266-1487 7.2e-74 243.7 In-house 2-226 (305) alignment 
Range on Protein: 1266-1487
Range on HMM: 2-226/305.0
LPISLNDLGNHVACCHSDSNAYFSEQFKDLYSGnDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKK
 .|.|.|| ...   ...|.  . .|.| ||.  .... || . .||  ||...|...||. | |.  . . ...||||||..||..  |.|.||||.|.
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPL
|..||| ||..||. ..||||.|||. | ||.||||.  .| ..||.|||.| .   ..||..|..... .|.. | ....||.||.|||||||..|| |
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

MTLHKRVMSSSAKG---PILVHCSAG
..| |||. .  |.   |.|||||||
lslikrvqkdqkkdkgvpllVhCsag
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1487-1601 3e-73 241.1 In-house 187-301 (301) alignment 
Range on Protein: 1487-1601
Range on HMM: 187-301/301.0
GWNIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIY
.|...|.||. |..|||.|.||||||||||||||||||||||.||||||||||.||||..||.||||||||||||||||||..|||||||||||||..||
swdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiy

EALEMYLAINSTYSN
....|||..||||.|
dvidmylqlnstyan
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1268-1487 8e-67 220.1 In-house 2-226 (290) alignment 
Range on Protein: 1268-1487
Range on HMM: 2-226/290.0
ISLNDLGNHVACCHSDSNAYFSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLK-LPGV--AQHEYINASYIHGYSKARKFIAAQGPMK
| ....|..||  |.  |  | .||| | ||. ...  |||   ||.||||.|||.|||| |||. ..|    ..|||||.||.||......||.|||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClnEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHG-VPEYAT
.|||||| |||||| . .||||| .|. |.|| ||||.   . ...|.||..||.. .. .|..|...|. .. .|. . .|||..|.|...| |....|
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

PLMTLHKRV--MSSSAKGPILVHCSAG
 |.......  .  . ...|.||||..
illvieemyktqrkrgntsivvHCSdt
0051299 (Phosphotyrosine protein) phosphatases II 1266-1488 3.3e-65 215.7 In-house 3-230 (288) alignment 
Range on Protein: 1266-1488
Range on HMM: 3-230/288.0
LPISLNDLGNHVACCHSDSNAYFSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMK
 .||...| ..|   . ...... |.|..|.| . | ..|..|   |.. ||...|.|||.. . |.  .||  . |||||||.|| . |||||.|||..
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQD---GSGEVHALTQYHLTTWPDHGVPEY
.|. ||| ..|...   .||||.|||....||.||||.  .. ...|...||||. .|..||..|.. ||  |   |.||..  |..| |.|||||||..
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

ATPLMTLHKRVMSS--SAKGPILVHCSAGW
...|... ..|...  | .||..|||||| 
pellldflrlvrkalasgggpvvVHCsaGv
subfamily_PTPRB_pd Subfamily PTPRB 1264-1487 3.6e-63 208.3 In-house 3-228 (293) alignment 
Range on Protein: 1264-1487
Range on HMM: 3-228/293.0
QTLPISLNDLGNHVACCHSDSNAYFSEQFKDLYS-GNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGP
.. ||.|... .||.  ..||.. |||....| . |.|.....  . .|.  ||..||.||| . . | .| . .. .||||.||.||.  |.|||.|||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

MKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIeQFGPFSVTLLEDYVMPDYVIRNISVTLqdgSGEVHALTQYHLTTWPDHGVPEYA
. .|. ||| ..|..|   .||||.|||  |.|||.|||.  ... ..|  .|||... .. |.|||.....    . | . ..||| |.|||||||| .
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPekt

TPLMTLHKRVMSS----SAKGPILVHCSAG
..|... ..| ..    ..|.||.||||||
ktlldfvrtvreaiektaskrPivvhCsaG
0050432 (Phosphotyrosine protein) phosphatases II 1268-1488 4.6e-63 208.7 In-house 26-243 (308) alignment 
Range on Protein: 1268-1488
Range on HMM: 26-243/308.0
ISLNDLGNHVACchSDSNAYFSEQFKDLYSGND-KQCSVGLNGMNKPLNRFRNIVPYDDNIITLklpGvAQHEYINASYIHGY--SKARKFIAAQGPMKK
.|. || ...     ... ...|.|..|.|  .  ..||.|   ||..||...|.||| . . |   .   . ||||||..||   . |||||.|||...
lsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...d.egsdYInAsyvdgyssklprkfIatqgPlpn

TLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLN-EIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgEVHALTQYHLTTWPDHGVPEYATP
|. ||| ..|...   .||||.|||... ||.||||  |. .....|.|.||||. .|..||..|.. .|  ... |.. .|..| |.|||||||.....
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspei

LMTLHKRVMSSSAKGPILVHCSAGW
|... ..| .|  .|||.|||||| 
lldflelvrkslpggpivVHCsaGv
0040438 (Phosphotyrosine protein) phosphatases II 1272-1488 1.8e-62 206.8 In-house 4-220 (317) alignment 
Range on Protein: 1272-1488
Range on HMM: 4-220/317.0
DLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFW
|| ...  ..  .. ...|.|.||.| .   .||..   ||..||...|.|||.. . |.  .|.  . ||||||..|... |||||.|||...|. |||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

CLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQdGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKR
 ..|...  ..||||.|.|... ||.||||.  .|  ..|.|.||||. ........|.. |.   |..|.. .|..| |.|||||||.. ..|  . ..
rmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldflea

VMSS--SAKGPILVHCSAGW
| ..  . .||.||||||| 
vrealedpggpvlVHCsaGv
0046845 (Phosphotyrosine protein) phosphatases II 1288-1488 4.5e-62 205.3 In-house 2-215 (284) alignment 
Range on Protein: 1288-1488
Range on HMM: 2-215/284.0
FSEQFKDLYSGNDK---QCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGV--AQHEYINASYIHGY-----SKARKFIAAQGPMKKTLVDFWCLIWQEK
. |.|. |.| . |   ..||.|   |. .||...|.|||.. . || ..     ..||||||..||      . .||||.|||...|. ||| ..|...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

PASVVMLTNLVEDSKTKCEQYWPQClNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSS---
   .||||.|||....||.||||.  .|  ..|.|.||||. .|..||..|....|  . .||.. .|..| |.|||||||.....|... . | ..   
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-SAKGPILVHCSAGW
 . .|||.|||||| 
lpgggpivVHCsaGv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1268-1487 1.5e-61 202.9 In-house 2-221 (287) alignment 
Range on Protein: 1268-1487
Range on HMM: 2-221/287.0
ISLNDLGNHVACCHSDSNAYFSEQFKDLYS--GNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYSKARKFIAAQGPMKKT
|... .|. ||  |  .|  |..||. | .   ....  ...   ||..||...|...|.. . ||     ...||||..| ||.....||.|..|| .|
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfnt

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNeiEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHG-VPEYATPL
...||.||.....  .|||... |. . .| ||||.  .    .|.....||.. |. .|..|.. |. .. .|. . ..||..|.|...| |.|..| |
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil

MTLHKRVMS--SSAKGPILVHCSAG
. ..... .   .....|.||||..
lvieemyktqrkrgntsivvhCsdt
0045450 (Phosphotyrosine protein) phosphatases II 1262-1488 1.3e-60 201.0 In-house 3-245 (307) alignment 
Range on Protein: 1262-1488
Range on HMM: 3-245/307.0
IPQTLPISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDK---QCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGV--AQHEYINASYI--------HG
.|  |.|.. .|  .|.  . |... . ..|..|.| ...    .|..|   ||..||...|.|||.. . |. ..     . ||||||.        .|
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

YSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYH
| . |||||.|||...|. ||| ..|...   .||||.|||. . || ||||.  .|  ..|.| ||||. .....|..|.. ||  ||.||.. .|..|
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfh

LTTWPDHGVPEYATPLMTLHKRVMS----SSAKGPILVHCSAGW
 |.|||||||..  .|  . ..|..    .. .||.||||||| 
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGv
0036941 (Phosphotyrosine protein) phosphatases II 1282-1488 1.3e-60 200.6 In-house 9-218 (297) alignment 
Range on Protein: 1282-1488
Range on HMM: 9-218/297.0
SDSNAYFSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLklpGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPAS
....|.....|..|..   .  .||.|.  |...||...|.|||.. . |   .   . ||||||. ||.  |||||.|||...|. ||| ..|...  .
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

VVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYV--MPDYVIRNISVTLQdGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS---
.||||.|||. . ||.||||   .|  ..|.|.||||. .|   .||..|.. ||   |.||.. .|..| |.||||||||....|. . ..| .     
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

-AKGPILVHCSAGW
  .||.||||||| 
psggpvlVHCsaGv
0043336 (Phosphotyrosine protein) phosphatases II 1267-1488 4.1e-60 199.0 In-house 1-221 (278) alignment 
Range on Protein: 1267-1488
Range on HMM: 1-221/278.0
PISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKT
||| .|| .... .. .... ....|..|.| .   .|..|   ||..||...|.||| . . |.| .|.  . ||||||. ||.. |||||.|||...|
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPqclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLqDGSGEVHALTQYHLTTWPDHGVPEYATPLM
. ||| ..|...  ..||||.|||....|| ||||   .. ...|.|.||||. ....||..|.. ||   |.||..  |.|| . ||||||||  ..|.
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslslll

TLHKRVMSS--SAKGPILVHCSAGW
 . |.|..   . .||.||||||| 
dflkavrealedsngpvlVHCsaGv
0039614 (Phosphotyrosine protein) phosphatases II 1258-1488 1.1e-59 197.7 In-house 4-233 (297) alignment 
Range on Protein: 1258-1488
Range on HMM: 4-233/297.0
FDPKIPQTLPISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKqCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGV--AQHEYINASYIHGYSK-ARK
. ... .. ||.|. |  .. . . .|. .. ..|..|.| ..  .|..|   ||..||...|.|||.. . || ..     . ||||||. ||..  ||
lrdallesipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrk

FIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKtKCEQYWPQCLNeieQFGPFSVTLLEDYVMPDYVIRNISVTLqdgSGEVHALTQYHLTTWPD
|||.|||...|. ||| ..|...  ..||||.|||... ||.||||.  .   ..|.|.||||. .. ..|..|...||    .||.. .|... | |||
fIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpd

HGVPEYATPLMTLHKRVMSSS----AKGPILVHCSAGW
||||.... |. . . |..       .||.||||||| 
hgvppslellleflelvrealaelpkggpvlVHCsaGv
0047943 (Phosphotyrosine protein) phosphatases II 1282-1488 1.9e-59 196.7 In-house 8-216 (273) alignment 
Range on Protein: 1282-1488
Range on HMM: 8-216/273.0
SDSNAYFSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLklpGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPAS
....... |.|..|.|   .  .||.|   || .||...|.|||.. . |   |   . ||||||. || . |||||.|||...|. ||| ..|...   
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

VVMLTNLVEDSKTKCEQYWPQCLNE-IEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMS----SS
.||||.|||... ||.||||.  .|  ...|.|.||||. .. .||..|.. .|  . . |..  |..| |.|||||||.. ..|... . |..    . 
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtg.esrtvthfhytgwpdhgvppslesllefielvrkalealp

AKGPILVHCSAGW
 .||..|||||| 
sngpvvVHCsaGv
subfamily_PTPRG_pd Subfamily PTPRG 1269-1487 1.7e-58 193.3 In-house 2-230 (563) alignment 
Range on Protein: 1269-1487
Range on HMM: 2-230/563.0
SLNDLGNHVACCHSDSNAYFSEQFKDLYSGND---KQCSVGLNGMNKPLNRFRNIVPYDDNIITLK-LPGVAQ-HEYINASYIHGYSKARKFIAAQGPMK
 .... .||| .|.|..  |||.|..| |       ...   .  ||  ||  |||.||   ..|. |||. . ..||||.||.|| |...|||.|||.|
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTL---QDGS--GEVHALTQYHLTTWPDHGVP
.|. ||| .||... | .||.|||||. . ||..|||.  .| |..| ..||| |  |.  | .|....     ....   ...  .||| |.|||||||
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

EYATPLMTLHKRVMSSSAK--GPILVHCSAG
|...| ..  |.   .  .  |||.||||||
ehslpvLifvkkssaankaeaGPivvHcsaG
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1267-1487 2e-58 192.9 In-house 4-226 (319) alignment 
Range on Protein: 1267-1487
Range on HMM: 4-226/319.0
PISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKT
.| ...| ...   .| .. .. ..||.|  ..... .   .  ||. ||..||..||   ..| .|.|| . .|||||.| || . .||||.|.|...|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLM
. ||| ..|.|.   |||||.|||  | |...|||.  ...|..| . |||.|.  . ||.||....  . .  |   ..... | ||||.|||.|| |.
iedfWrmvWeeessivvmltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

TLHKRVMSSSAK---GPILVHCSAG
 | ||.  |  |   ||| ||||||
dllkrirksrektqsgPivvhCsaG
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1270-1487 4.9e-58 191.5 In-house 6-222 (288) alignment 
Range on Protein: 1270-1487
Range on HMM: 6-222/288.0
LNDLgNHVACCHSDSNAYFSEQFKDL-YSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLV
.... ..||  . .... |||... |   ...|. ..| .  |.. ||.|||.||| . . ||  . .|. .|||||||.|. | .|.||.|||. .|. 
ispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvn

DFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClNEIEQFGPFSVTLLEDYVMPDYVIRNISVTlqdGSGEVHALTQYHLTTWPDHGVPEYATPLMTL
||| |....|   .||||.|||. |||||.|||.  .. ...| . |||.|.  . |.| |.. .     ...   .|||. ..|||||||| ..||. |
dfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllel

HKRVMSSS--AKGPILVHCSAG
 . |  ..    |||.||||||
lrqvkvanqadtgpiivhCsaG
DSPc_SM00195 1288-1488 1.3e-56 187.2 In-house 2-206 (263) alignment 
Range on Protein: 1288-1488
Range on HMM: 2-206/263.0
FSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPG-VAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLT
..|.|..| . . .|... .    ||  ||..||.|||.. . || .    ...||||.|| |..| .|.||.|||...|. ||| ..|.||   .||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMP-DYVIRNISVTLQDGsGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSA--KGPILV
. .|. |.||..|||.  .. |.|| .||.| |   .. ....|....| ..   | . .|||. ..|||||||. ..... | . | .|.   .|||.|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGW
||||| 
hCsaGv
PTPc_SM00194 1288-1488 1.3e-56 187.2 In-house 2-206 (263) alignment 
Range on Protein: 1288-1488
Range on HMM: 2-206/263.0
FSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPG-VAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLT
..|.|..| . . .|... .    ||  ||..||.|||.. . || .    ...||||.|| |..| .|.||.|||...|. ||| ..|.||   .||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMP-DYVIRNISVTLQDGsGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSA--KGPILV
. .|. |.||..|||.  .. |.|| .||.| |   .. ....|....| ..   | . .|||. ..|||||||. ..... | . | .|.   .|||.|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGW
||||| 
hCsaGv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1268-1487 3e-56 185.8 In-house 2-223 (318) alignment 
Range on Protein: 1268-1487
Range on HMM: 2-223/318.0
ISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDK-QCSVGLNGMNKPLNRFRNIVPYDDNIITLK-LPGVAQHEYINASYIHGYSKARKFIAAQGPMKKT
||..|| .||.  ... . ..||... |   ...      |. .||  ||. ||..||.  . |. | |. . .||||.|| || . ...||||.|. .|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLqDGSGEVHALTQYHLTTWPDHGVPEYATPLM
. ||| ..|. . | .||||...| .|.|...|||.  .. ...|   |.| |.  . |||.|...||  ... |.    ||| |.|||.|||| .. |.
ieDfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgasll

TLHKRVMSSS---AKGPILVHCSAG
 | ..| .      .|||.||||||
dlvrqvskaqqksgagpivvhCsaG
subfamily_Ptp69D_pd Subfamily Ptp69D 1268-1487 1.4e-54 180.3 In-house 4-229 (307) alignment 
Range on Protein: 1268-1487
Range on HMM: 4-229/307.0
ISLNDLGNHVACCHSDSNAYFSEQFKDLY-SGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKT
|.. || . .   . |..  . . .. |  .  ||...|. .  |.  ||. .|...|.. . | |..| .. .|||||.|.|| . .||||||.|.  |
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClnEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSG----EVHALTQYHLTTWPDHGVPEYA
. ||| .|.. .   .|||.|| | .. ||..|||.   .. |.|   |.| .   ..||.||...|. .. ..    . . ..||| |.|.|  ||| |
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TPLMTLHKRV--MSSSAKGPILVHCSAG
. |. | ..|  . .  ..||.||||||
rgllklieqvrelyklnrsPivvhCsaG
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1267-1487 4.7e-54 178.4 In-house 5-222 (315) alignment 
Range on Protein: 1267-1487
Range on HMM: 5-222/315.0
PISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQH-EYINASYIHGYSKARKFIAAQGPMKKT
|| |..|  .||  .. ..  | .... .  |. .   |  . .||  ||. ||..||   . | |  . .| .|.||..| ||.| |..||||||   .
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvas

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClneIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDgsgEVHALTQYHLTTWPDHGVPEYATPLM
. ||| |...|. . .||||||||. | |.|.|||        .|...||. .. |  .| .| .||. .|   ... . |.|.|.||| |||.|..|||
vkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgd...nirevvqlhytswpdmgvpkytiplm

TLHKRVMSS--SAKGPILVHCSAG
 |...|.    .. |.|.||||||
nlirtvkqhhtnsvgaivvhcsaG
0045098 (Phosphotyrosine protein) phosphatases II 1289-1489 1.4e-53 177.4 In-house 11-218 (278) alignment 
Range on Protein: 1289-1489
Range on HMM: 11-218/278.0
SEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITlklpgvaqhEYINASYIHGYsKaRKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLV
.| .  |  |.  .....|   |...||...|.||| . .          .|||||||.|| . .||||.|||...|. ||| ..|...  ..||||.||
lefefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy.p.kkfIatqgPlpstvadfwrmlwelgitvivmltelv

EDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQ---DGSGEVHALTQYHLTTWPDHGVPEYA--TPLMTLHKRVMSS---------
|... ||.||||   .. ...|.|.||||. .|..||..| . ||     . ..| . .|..|...|||||||..   ...  | ... .          
elgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

------SAKGPILVHCSAGWN
      . .||.|||||||..
sslllldsggpvlVHCsaGvg
Y_phosphatase Protein-tyrosine phosphatase 1311-1488 3.7e-53 175.7 Pfam-A 1-181 (235) alignment 
Range on Protein: 1311-1488
Range on HMM: 1-181/235.0
NKPLNRFRNIVPYDDNIITLKLPGVAQHeYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFG
||  ||...|.|||.. . ||  . ..  ||||.|..||.. .||||.|||.|.|. ||| ..||||  ..||||.|.| ...||.||||.  .| ...|
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PFSVTLL-EDY-VMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS--AKGPILVHCSAGW
 ..|.|  .    . .|..|..... .... | . ..|.|.|.|||||||| ...|. | ..| .|.   .||..|||||| 
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGv
Y_phosphatase Protein-tyrosine phosphatase 1311-1488 3.7e-53 175.7 In-house 1-181 (235) alignment 
Range on Protein: 1311-1488
Range on HMM: 1-181/235.0
NKPLNRFRNIVPYDDNIITLKLPGVAQHeYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFG
||  ||...|.|||.. . ||  . ..  ||||.|..||.. .||||.|||.|.|. ||| ..||||  ..||||.|.| ...||.||||.  .| ...|
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PFSVTLL-EDY-VMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS--AKGPILVHCSAGW
 ..|.|  .    . .|..|..... .... | . ..|.|.|.|||||||| ...|. | ..| .|.   .||..|||||| 
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGv
subfamily_PTPN6_pd Subfamily PTPN6 1286-1487 5e-53 175.1 In-house 26-237 (306) alignment 
Range on Protein: 1286-1487
Range on HMM: 26-237/306.0
AYFSEQFKDLYSGNDKQ---CSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQHEYINASYIHGYS--KARKFIAAQGPMKKTLVDFWCLIWQEKPAS
| |.|.|..|   . |.    . |    ||  ||..||.|.|.. ..|| |.|....||||.||.. .  . ...||.|| ...|. ||| ..|||.   
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

VVMLTNLVEDSKTKCEQYWPQCLNEIEqFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTL----HKRVMSSS-
.||.|. || .| || .|||.  .. | .|  ||| ...  . ||..|..||. .. ..| . . ||| ..|||||||.    .. .    ...  ... 
ivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

-AKGPILVHCSAG
  .|||.||||||
aeagpivvhCsaG
0040439 (Phosphotyrosine protein) phosphatases II 1303-1488 7.7e-53 175.0 In-house 3-190 (249) alignment 
Range on Protein: 1303-1488
Range on HMM: 3-190/249.0
CSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQ
.||.|   ||..||...|.||| . . |.  ||.  . |||||||.||   |.|||.|||...|. ||| ..|...  ..||||.|||  . ||.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

clNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQdGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS----AKGPILVHCSAGW
  ..  ..| |.||||. .|..||..|.. .|   . ||..  .... | |||||||..  .|. . ..|..       .||.||||||| 
..ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1281-1487 3.7e-52 172.4 In-house 22-233 (298) alignment 
Range on Protein: 1281-1487
Range on HMM: 22-233/298.0
HSDSNAYFSEQFKDLYSGND----KQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQ
.. . . ....|. | |...    .. .|. .  ||  ||. .|...|   . |.   .  . .|||||..|.|..   |||.|.|...|..||| ....
kkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvte

EKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS
|. ...||||||.|  |||...|||.  .. |..| ..|.||..... |...|.. |. .. . . . . | | |.|||.||||.|| ...| ..|  | 
edigtiVmltnleeldktkyhkywPd..egketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasq

-AKG--PILVHCSAG
   |  |..|.||||
qqagnkpvivqCsaG
subfamily_PTPRA_pd Subfamily PTPRA 1266-1487 5.7e-52 171.6 In-house 12-238 (330) alignment 
Range on Protein: 1266-1487
Range on HMM: 12-238/330.0
LPISLNDLGNHVACCHSDSNAYFSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMK
 |. ...| . .    .| |  | |.|. | .|. .  . .  .  ||  ||. ||.||| . . | .. || . .|||||.|.|| .  |||||||| .
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVT-LQDGS--GEVHALTQYHLTTWPDHGVPEY
.|. ||| .||. | |..||||.| |  ..||.||||.  . .  .|   |.. .. |. || .|.. |. | |..   ..  ..|.|.|.||| |||  
etvedfwrmiweqksativmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

ATPLMTLHKRVMSS--SAKGPILVHCSAG
.  .. | |.| .      ||| ||||||
piGmlkllkkvkklnqqsagpivvhcsaG
0042113 (Phosphotyrosine protein) phosphatases II 1304-1488 6.2e-52 171.8 In-house 2-187 (245) alignment 
Range on Protein: 1304-1488
Range on HMM: 2-187/245.0
SVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQ-HEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQc
||.|   ||..||...|.|||.. . |. .|    . ||||||..||   .||||.|||...|. ||| ..|...  ..||||...|... ||.||||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

lNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLqDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMS---SSAKGPILVHCSAGW
 .|. ..| |.||||. ....||..|...||  .|..|..  ..|| . |||||||..   |  ....| .   ....||.||||||| 
.gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1282-1487 1.7e-51 169.9 In-house 14-219 (515) alignment 
Range on Protein: 1282-1487
Range on HMM: 14-219/515.0
SDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPAS
.   . |||.|.||   |    .|  . .| . ||..||.||| . . |  .    ...|.|||||...   . .||.||| | .. ||| |..||... 
nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvtt

VVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGsgeVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK--G
..|.|.| |. | || .|||.   .  .|| ..| |.      . ..|.. |. .|    ....||.|.| |||.|||. .. |. | | | ..  .   
iamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyth

PILVHCSAG
|...|||||
pliihcsaG
subfamily_PTPN12_pd Subfamily PTPN12 1303-1487 1.7e-51 169.9 In-house 32-217 (290) alignment 
Range on Protein: 1303-1487
Range on HMM: 32-217/290.0
CSVGLNGMNKPLNRFRNIVPYDDNIITLKLPG-VAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQ
 ..| .  |.  ||...|.||| . ..|.    . . .||||..|.| ..  ..||||||. ||| ||| .||. .   |||. ..||  |.|||.|||.
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

CLNEIEQFGPFSVTLLEDYVMP-DYVIRNISVTLQdgsGEVHALTQYHLTTWPDHGVPEYATPLMTLHKR--VMSSSAKGPILVHCSAG
  .|  .||.|.||| |.  .  |..|| . |. |   .| . ..|.| | |||||||. |..|. | .    . .| . |..||||||
egeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaG
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1283-1487 7.1e-51 167.9 In-house 16-220 (315) alignment 
Range on Protein: 1283-1487
Range on HMM: 16-220/315.0
DSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASV
   | |||.|.||   .  .  |. . .| . ||..||.|.| . . |  .    ...|||||||... . . .||.||| | .. ||| ...|||....
rhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtti

VMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNIsVTLQdgSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSA--KGP
||.|.. |. | || ||||.   .  .|| ..|.||.     | |.|.. || .  | | . .||...| |||.||.. .. |. | | | ..    . .
vmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefs

ILVHCSAG
.|||||||
llvhcsaG
subfamily_PTPRK_pd Subfamily PTPRK 1269-1487 1.9e-50 166.5 In-house 5-220 (314) alignment 
Range on Protein: 1269-1487
Range on HMM: 5-220/314.0
SLNDLGNHVACCHSDSNAYFSEQFKDLYSGndkqCSVGLNGMNKPLNRFRNIVPYDDNIITLK-LPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLV
  .|| ...|. .   .  | |... |. |      .  .  |.  ||. .|..||   ..|. . | .. .||||..| .| ....||..|||...|. 
rvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclnEIEQFGPFSVTLLEDYVMPDYVIRNISVTL-QDGSGEVHALTQYHLTTWPDHGVPEYATPLMT
||| |...|. ||.||||.||| .. || .|||.   . |..|.. |.|.|  .  ..|.|  .|.  . |  |.. . |.. ..||||.|| .|| |..
dfWrlvydencasivmltelvevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk

LHKRVMSSS--AKGPILVHCSAG
| .|| .|.   .|.|.||||||
lvrrvkksqeeeaGrivvhCsaG
0037934 (Phosphotyrosine protein) phosphatases II 1303-1488 4e-50 166.0 In-house 2-189 (243) alignment 
Range on Protein: 1303-1488
Range on HMM: 2-189/243.0
CSVGLNGMNKPLNRFRNIVPYDDNIITLklPGvaqHEYINASYIHGYskaRKFIAAQGPMKKTLVD----FWCLIWQEKPASVVMLTNLVEDSKTKCEQY
.|..|  .|.. ||...|.|||.. . |  .|   . ||||..| ..   ...|| |||...|. |    || ..|...  ..||||.||| .. ||.||
fsiallpenlsknrysdilpydhsrvkl..eg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPqclNEIeQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVM----------SSSAKGPILVHCSAGW
||   .|. ..|.|.||||. ....||..|.....  | .....  ..|| . |||||||.  ..|. ... |             . .||.||||||| 
wp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1304-1487 2.4e-48 159.6 In-house 2-185 (250) alignment 
Range on Protein: 1304-1487
Range on HMM: 2-185/250.0
SVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTkCEQYWPqc
||. .  ||  ||. .|...|   . |.   |  . .|||||..|||.. . |||.|||...|..||| ....|| ...||||||.|  || ..||||  
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..

LNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHaLTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK---GPILVHCSAG
 .. |..|   |.||.. .. ||..|.. .. .  ..|.. . |.| ..||| ||||.||  . | |.| .|  .   .|..|.||||
vekaekyGdvtvsllskeefadytkrklklskakkaderi.vrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaG
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1310-1487 3.5e-48 159.6 In-house 60-234 (319) alignment 
Range on Protein: 1310-1487
Range on HMM: 60-234/319.0
MNKPLNRFRNIVPYDDNIITLK-LPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTnlvedsKTKCEQYWPQCLNEIEQ
 ||  ||. ||...| |.. |. | |.   .|||||.. || .  |.||||||.. || ||| .||. . ...|.||      | || ||||.  .. |.
qnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

FGPFSVTLLEDYVMpdYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMS----SSAKGPILVHCSAG
 .  .|...|.     ||.|.| .. .    ..  .||.|.  |||.|||.|...||.| |.|         . .|.||||||
rfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaG
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1310-1487 1.2e-47 157.8 In-house 24-198 (284) alignment 
Range on Protein: 1310-1487
Range on HMM: 24-198/284.0
MNKPLNRFRNIVPYDDNIITLK-LPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTnlvedsKTKCEQYWPQCLNEIEQ
 ||  ||. .|...| |.. |. | |.   .|||||.| || .  |.||.|||.. || ||| .||. . ...|.||      | || ||||.  .. |.
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

FGPFSVTLLEDYVMpdYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMS----SSAKGPILVHCSAG
 .  .|...|.     ||.|.| .. .    ..  ..|.|.  |||.|||.|...||.| |.|         . .|.||||||
rfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsag
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1275-1487 4.4e-47 155.5 In-house 4-218 (281) alignment 
Range on Protein: 1275-1487
Range on HMM: 4-218/281.0
NHVACCHSDSNAYFSEQFKDLYS-GNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCL
.|..  ....|| | |....|.. |.|.  .   .  |.  ||..||| ||   ... .     . .||||... ||.. ...||.|||. ..||.|| .
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIeQFGPFSVTLLEDYVMPDYVIRNISVtlQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRV-
.|..|   .||.|. .| .| || .|||.  .|. ..| . |. ..    . |. |....  .  |||   ..| . |.|||||||. .. |.  .| | 
vweqkvsaivmvtreieagklkChrYWPddnsel.kygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevl

--MSSSAKGPILVHCSAG
   ... | |...|||||
kltekktkaplvihCsaG
subfamily_PTPN3_pd Subfamily PTPN3 1290-1487 2.8e-46 152.7 In-house 19-218 (280) alignment 
Range on Protein: 1290-1487
Range on HMM: 19-218/280.0
EQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIH----GYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVML
 ||. ||  . . ..|.     | . ||.|.|.|||.  ..||    .. .||||.|.     . .   ..||.|||..||  ||| ..|..|   .|||
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk...esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TNLVEDSKTKCEQYWPQcLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDgSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSS--SAKGPILV
|.|||. ..|| ||||.  ..  ..| |||.. ..     ||.|.. .. .. . | . ..|   . |||||||. .. .... .|| .   ... |..|
ttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvv

HCSAG
|||||
hCsaG
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1311-1487 2.8e-45 149.4 In-house 3-182 (237) alignment 
Range on Protein: 1311-1487
Range on HMM: 3-182/237.0
NKPLNRFRNIVPYDDNIITLKLPGVAqHEYINASYIHGYSK-ARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClNEIEQF
||  ||. ||| || . . || .| .  .||||.|..|.    .|.||||||.. .  ||| ..|||| . .|||| |.|  . || .|||.  .. . .
nkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaay

GPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK----GPILVHCSAG
| ..|.|  .  . || .| . .. .    ||  . ||..|.|||.|||.... |. . |...  | .    || ..|||||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsag
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1269-1487 1.8e-43 143.9 In-house 6-231 (325) alignment 
Range on Protein: 1269-1487
Range on HMM: 6-231/325.0
SLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQH-EYINASYIHGYSKARKFIAAQGPMKKTLV
.. .| .||   ... .  |. .|. | | . .   |     ||  |||.|.|..| . . |.  . . . .||||||.. . |   |.||| |. .|. 
avvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

DFWCLI--WQekpASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTlQDGSGEVHALTQYHLTTWPDHGVPEYATPLM
|.| |.  |.   .|||...| ..  | .| .|||. . .  .||.. | |     . ||| | . |  |   ||  .. |..| .|.| ||... . |.
dlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvk.qvkkGetrsvkqfqlqswddmGvqkrpatli

T-------LHKRVMS-SSAKGPILVHCSAG
.       ...|| . . | .|||||||||
silqlvkavservtantkastpilvhcsaG
subfamily_PTPN23_pd Subfamily PTPN23 1284-1488 3.6e-43 142.4 In-house 13-223 (288) alignment 
Range on Protein: 1284-1488
Range on HMM: 13-223/288.0
SNAYFSEQFKDLYSGND---KQCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYS-KARKFIAAQGPMKKTLVDFWCLIWQEKPA
 .. . ..||.| . .|   .. |. .  ..   ||.|.|.||| | ..|.     . .|||||.... |  . .|||.|.|...|| ||| .....|  
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkss

SVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMS------
 .|||..  |  |.|...|||.  .| ..||..|||| .   .. .| |..... .| . .|. ..  .||.||..|||.    |. . . | |      
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavq

SSAKGPILVHCSAGW
  .| |..|||||| 
rksktPlvvhCsaGv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1284-1487 1.7e-42 140.2 In-house 7-209 (283) alignment 
Range on Protein: 1284-1487
Range on HMM: 7-209/283.0
SNAYFSEQFKDLySGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVaqhEYINASYIH---GYSKARKFIAAQGPMKKTLVDFWCLIWQEKPAS
.|  | |..| | |  |... .  .  ||. ||...|||.| ... ||       .||||..|     | . .|.|.||.|...| |||| ....|| ..
nnklfrevlkrl.svpdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

VVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPL--MTLHKRVMSSSAKG
.||||.| || . || ||||.  .  |..|.| ||| ...    ..|... .  .  . .   |. | .  | . |       |  . . .     | ||
ivmltklqedlrikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkg

PILVHCSAG
||.||||.|
PivvhCstg
subfamily_PTPN13_pd Subfamily PTPN13 1291-1487 2e-41 137.1 In-house 16-212 (273) alignment 
Range on Protein: 1291-1487
Range on HMM: 16-212/273.0
QFKDLYSG-NDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVaqheYINASYIHGYSK--ARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNL
.||.|      ..|.|| .  ||  ||.||..|||.  ..|.  |     |||||.|.        ..||.|||. .|  ||| ..|. |   ..|.|. 
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

VEDSKTKCEQYWPQCLNEIEQFGP-FSVTLLEDYVMPDYVIRNISVTlQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSA-KGPILVHCS
.|. | ||..|||.  |.  .    . |.||.   . ..|.|.. |. .  |||.. ... ....|||||||  |..|... ..| .    .|||.||||
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk.dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcs

AG
||
aG
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1303-1487 3.7e-41 136.0 In-house 21-211 (274) alignment 
Range on Protein: 1303-1487
Range on HMM: 21-211/274.0
CSVGLNGMNKpLNRFRNIVPYDDNIITLKLPGVAQH--EYINASYIHGYSKARK-FIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYW
  . . | ..  ||...|.| .   ..|.   . ..  .|||| ||.||..  | ..|.|||. .|. ||| .|.||.   .||||.| |  ..||..|.
eeldvfgsqt.knryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyf

PQCLNE--IEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGsgeVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSS----SAK-GPILVHCSAG
|.  .    |..| ....  .     || .|....  .      . .. |  | |||| .|. |..|. | . | .|    .|| .|..||||||
Pdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1267-1487 6.2e-41 135.4 In-house 9-227 (297) alignment 
Range on Protein: 1267-1487
Range on HMM: 9-227/297.0
PISLNDLGNHVAccHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVA-QHEYINASYIHGYSKarKFIAAQGPMKKT
|| | |.   |   .. .  .|||.|..| . | ..  |  . .| . .|..||.||| . ..|.  .   . .|.|||...|. .  ..|. | ||| |
piplsdfatlvq..knrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkat

LVDFWCLIWQEKPASVVMLTNLVEDSKtKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDgSGEVHALTQYHLTTWPDHGVPE-----Y
. ||| ....|... .|||... |  | || .||..  . . .||  ||.||       .. |...|| .. .   . . ||. . |||. |..     .
vadfWamvldeqvstivmlnddnerdk.kcaryWsd..kgvttfGdvsvvllsvsereGfikrelevtkgk.akarrvvkqyqfveWPdkaverkdsass

ATPLMTLHKRVMSSSAKGPILVHCSAG
   |..  . . |. |.||.||||.||
llklisevrkdfsqnaegPllvhclaG
subfamily_PTPN9_pd Subfamily PTPN9 1310-1486 7.4e-41 135.1 In-house 41-232 (297) alignment 
Range on Protein: 1310-1486
Range on HMM: 41-232/297.0
MNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQ
.|   ||. ... ||.  ..| |...  . .||||... || . . |||.|||.|||  ||| ..|...   .|| | .||  . || ||||.  .. ..
anleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessae

FGPFSVTLLEDYVMPDYVIRNISVTLQDgSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK---------------GPILVHCSA
|| .||. .|. .. ||..| . ..  .  .|   .| . ...|||.|||. |. |. . . | .  |.                ||.|||||
fgdlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa
subfamily_PTPN1_pd Subfamily PTPN1 1299-1487 8.2e-41 134.6 In-house 20-211 (290) alignment 
Range on Protein: 1299-1487
Range on HMM: 20-211/290.0
NDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLpgvAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQY
.| ....  .  |..|||.|.. |||   |.|.    |. .||||| ..     |..| .|||. .|   || ..|..|  .|||| ..|| ...|| ||
sdfptreaklpenrnlnryrdvspydhsrikler...adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPQCLN-EIEQFG--PFSVTLLEDYVMPDYVIRNISVTlQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSS----SAKGPILVHCSAG
|||  . .  ..    ..|.|..  .   |..| . .. .  . | . ....| ||||| ||||  . .. .  .| .|    | .|| ..|||||
wPqgeeekellledtklkvkliseerksyytvrllele.nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1310-1488 8.4e-41 134.7 In-house 7-185 (239) alignment 
Range on Protein: 1310-1488
Range on HMM: 7-185/239.0
MNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKAR-KFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClneIE
.||  ||. ||| || . . | ||    . .||||||.. |  .   .||.|| .. .  ||| ..|||. . .|||| |.|  | || ||||.      
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...ts

QFGPFSVTLLEDYVMPDYVIRNIsVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAKG--PILVHCSAGW
..  . ||| .  |. ||.|| . |  | |  | . . |||.| |||.|||.||| .. |....   |  |  | ..||||| 
kycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1310-1488 1.1e-40 134.2 In-house 6-184 (239) alignment 
Range on Protein: 1310-1488
Range on HMM: 6-184/239.0
MNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKAR-KFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClneIE
.||  ||. ||| || . . | ||    . .||||||.. |  .   .||.|| .. .  ||| ..|||. . .|||| |.|  | || ||||.      
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...ts

QFGPFSVTLLEDYVMPDYVIRNIsVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAKG--PILVHCSAGW
..  . ||| .  |. ||.|| . |  | |  | . . |||.| |||.|||.||| .. |....   |  |  | ..||||| 
kycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1489-1596 5.9e-40 132.3 In-house 179-286 (305) alignment 
Range on Protein: 1489-1596
Range on HMM: 179-286/305.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
...|.|.  | ..|| . . ..|..|..| ..|.|  | |..||||..|.||||..|..||||..|.|.|||||.|.|.|.......|.||.||  ...|
tvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhda

LEMYLAIN
|. ..   
ldelitcg
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1294-1487 1.1e-39 131.0 In-house 3-207 (270) alignment 
Range on Protein: 1294-1487
Range on HMM: 3-207/270.0
DLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSK-ARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDS
.|  .. .. ..     .| |||...|.|     ..| .|    . .|||| |..|...  .|.|||.||.. || .|| .||.||  ..||.|.|.|. 
eldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkg

KTKCEQYWPQCLNE--IEQFGPFSVTLLEDYVMPDYVIRNISVTlqdGSGEVHALTQYHLTTWPDHGVPEYAT------PLMTLH---KRVMSSSAKG-P
..|||.|||.  .|    ..|  .|. |..  .  |..... ..    .|| . |. .. .||||||||. .        |...    .|. .. .|. |
rkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaeP

ILVHCSAG
.|||||||
llvHcsaG
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1297-1487 5e-39 128.8 In-house 38-220 (287) alignment 
Range on Protein: 1297-1487
Range on HMM: 38-220/287.0
SgndkqcsvglngmnKPLNRFRNIVPYDDNIITLKLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCE
.                 ||. ...|.||. . |   |    .|||| |. .| .  .|||||||.  |. |||....... |||...|  ||... || 
a..............vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPQClNEIEQFGPFSVTLLE-DYVMPDYVIRNISVTLQDGSgEVHALTQYHLTTWPDHGVPEYATPLMTLHKRV-------MSSSAKGPILVHCSAG
.|||.  .   . | .||.||. |   |.| .| . .   ..  | . . |..| .|||....  |  |. .   |        ..|  ||..||...|
kywPer.evPmrvGGysvvlldydikePeygvralrlidletr.earvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1272-1487 3.2e-37 123.0 In-house 6-222 (439) alignment 
Range on Protein: 1272-1487
Range on HMM: 6-222/439.0
DLGNHVACCHSDSNAYFSEQFKDLYSGNDK-QCSVGLN--GMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLV
.. .||   . . .  |.| |. . | . . .|   |     ... ||.......|   .|| ..||| .  |||| ||.|| . . .||.||| |.|  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWCLIWQEKPASVVMLTNLVEDSKtkceqYWPQCLNeiEQFGPFSVTLLEDYVMPDYVIRNISVTLQ-DGSGEVHALTQYHLTTWPDHGVPEYATPLMT
||| |....| . .||||||||  |     |||   .    .|  .|    .  .|.|||| . |  . | .   ... |.| ..|||. ||  |. .. 
dfwrlviekktvtivmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

LHKRVMSSS---AKGPILVHCSAG
. . . |.      ||..||||||
flrainsandkeeygpvvvhcsag
subfamily_CG42327_pd Subfamily CG42327 1311-1593 3.6e-36 119.4 In-house 28-315 (319) alignment 
Range on Protein: 1311-1593
Range on HMM: 28-315/319.0
NKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKAR-KFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQ--CLNEI
 |. .|. |.||  .  ..| . .   . ||..|||. || .|.  .|||| .....  ||| ..|. .   .| ||.| |    .| .|.|    |.. 
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

EQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgEVHALTQYHLtTWPDHGVPEYATPLMTLHKRVMSS-----SAKGPILVHCSAGWNIVqFQVIGWMND
. .| . ||| .  |   |.|  . .   |.. |   || |    |.. .||   ..|...  .| ||       .   | . ||  .   ... |   .
slyGdilvtlkgrevkdryaistlllkrvdke.esrelthywy.kwleaevPaeeaaliamllevrsslksysleqanelreksatlets.mdadgskae

GVLRDPRTVLQVIDDVIHrqQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRSKPGAVTTLEQYITIYEALEMYL
      . .   |       ..   ||.|||||| | |||.  |  ||... .     ||. |.   ..| .  || | |||  ||  | .| 
agstssheingnissrsg..tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1490-1600 6.3e-35 115.4 In-house 180-290 (290) alignment 
Range on Protein: 1490-1600
Range on HMM: 180-290/290.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..|.|.  | ..| . .| |.|.||  ... | | | ..|||||||||.|..|.||. .....|| |||.||||| | ..  ||| |.| .|| .|.. .
vtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv

EMYLAINSTYS
  ||   .|||
ltyldsfetys
subfamily_CG7180_pd Subfamily CG7180 1300-1487 1.8e-34 113.7 In-house 31-233 (296) alignment 
Range on Protein: 1300-1487
Range on HMM: 31-233/296.0
DKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKtKCEQY
  .|  ||.  |.  ||  ..|||| | . | || | .. .||||.|. .. | ...|  ..|.|.|. .|| |...|.  .||.||.  . .| .. .|
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPQCLneIEQFGPFSVTLLEDYVMPDYVIRNISVTLQ---------DGSGEVHALTQYHLTTWPD-HGVPEYATPLMTLHKRVMSSS-------AKGPIL
||.     ||.|.. | ..|   ... .||.. .| .         . . |.  .....||.|.  . ||  .. |. | .|| .          .||..
wpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCSAG
|..| |
vvssdG
subfamily_PTPN14_pd Subfamily PTPN14 1299-1487 2.5e-34 113.6 In-house 37-239 (300) alignment 
Range on Protein: 1299-1487
Range on HMM: 37-239/300.0
NDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQHEYINASYIHG--YSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCE
.| ..|.. .  |.. |||....||.|| . |.    ....||||| |.    .| |..|.||||...|. ||| ..|... . .||||.  || |.|. 
edallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

QYWPQC--LNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQdGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRV-------MSS----SAKGPILVH
.|.|..   ..  .|| | ||       . .. . . .     |.|   .     | ||||||||  .. .   ..|        |.    ..| |.|||
kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl.pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvh

CSAG
||||
CsaG
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1284-1487 2.8e-34 113.2 In-house 18-179 (392) alignment 
Range on Protein: 1284-1487
Range on HMM: 18-179/392.0
SNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVV
 .| |.|.|.|| . .  . .|. . .|.. ||..||.||| . . |  .  .....|.|||||...   . .||.|||   .| ||| ...||......
hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttia

MLTNLVEDSktkceqywpqclneieqfgpfsvtlledyvmpdyvirnisvtlqdGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS--AKGPI
|.|.| |                                                  .... .|.|.| |||..||.... |. . | | .       |.
mvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpl

LVHCSAG
..|||||
iihcsag
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1314-1588 7e-34 112.0 In-house 36-290 (297) alignment 
Range on Protein: 1314-1588
Range on HMM: 36-290/297.0
LNRFRNIVPYDDNIITLKlPGVAQHEYINASYIHGY--SKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGP
 ||.|.|. .||. . |.  ......|||| |.      .  |.| ||||...|. ||| |....    .||...| || . ||  |||.. .|  . | 
knryrdilatddtrvkll.rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagd

FSVTLLEDYVMPdYVIRN-ISVTLQDGsGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAKGPILVhcsagwNIVQ-FQVIgwmndgVlrdprt
. |  | ..    .       ..|     |   ..     .|||||||     |  .. .| |     |...       .|. | ..      |      
vvveflsstsde.fdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmml......alvemftam......v......

VLQVIDdviHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
.||.      | ..    ...||||  | |.||     . |.. . . . ||  . . |.  ..  | ||||.  .|.|
flqles...lraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_PTPRN_pd Subfamily PTPRN 1296-1487 1.1e-33 111.2 In-house 41-234 (297) alignment 
Range on Protein: 1296-1487
Range on HMM: 41-234/297.0
YSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVA-QHEYINASYIHGY-SKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKT
|  ... ..|. .  |   || ....|||.....||    | ...||||| |     .|  .||.|||. .|. ||| ..|..  . .|.||.| |.. .
yeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvk

KCEQYWPQCLNEIeqFGPFSVTLLEDYVM-PDYVIRNISVTLQDgSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS--AKGPILVHCSAG
.|..|||.  .|.  .. . | |. ...   ||..| . .   . . |  ..||.|  .||..|||  | .|. . ..|  |      ||.||||.|
qckrywpdeGsev..yhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdG
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1489-1602 1.7e-33 110.8 In-house 174-287 (287) alignment 
Range on Protein: 1489-1602
Range on HMM: 174-287/287.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
...|.|.  | . | . .|.|.| ||.. .. |.| | ..||||||||| |....||. .....|| |||.||||| |  .  |||.| | |||. |...
qvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindi

LEMYLAINSTYSNF
. .||   .|||.|
vleyldsfetysdf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1315-1487 2.1e-33 110.2 In-house 60-226 (290) alignment 
Range on Protein: 1315-1487
Range on HMM: 60-226/290.0
NRFRNIVPYDDNIITLKlpGVAQHEYINASYIHGYSKarKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSV
||....|  |   . ||     . .|. | |..|      || .||..|.| .|.| .. ||| | .||| .|.|| |.|||||.|.   |.  || ..|
nrykdvvcndktrvilk..dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitv

TLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVmsSSAKGPILVHCSAG
.  |.    . .|...    .  ||  | |  ... .|||. |.  .  |. . . .    | ||. ||||||
lcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rkasGpvvvhcsaG
0051429 (Phosphotyrosine protein) phosphatases II 1339-1488 4.6e-33 110.4 In-house 5-161 (272) alignment 
Range on Protein: 1339-1488
Range on HMM: 5-161/272.0
EYINASYIHGYSK---ARKFIAAQGPMKKTLVDFWCLiWQEKPASVVMLTNLVEDSKTKCEQYWP----------QCLNEIEQFGPFSVTLLEDYVMPDY
 ||||... || .    .......||.. |  ||| | ....  ..|.|....|  . ||..|||              .   .| ..||||. ....||
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYAtpLMTLHKRVMSssaKGPILVHCSAGW
..|.. .||. . ||.. ....| | |||||||. |  | .| . . .   .||.|||||||.
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1291-1487 9.7e-32 105.2 In-house 21-219 (307) alignment 
Range on Protein: 1291-1487
Range on HMM: 21-219/307.0
QFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQhEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVED
.|. |   . .  .|     |   ||....   | . | .|..|.|  .|| | |.    | .|||.||||...|  .||... |||  ||.|| ...| 
efrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglas.dyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckviel

SKTKCEQYWPQCLNEIEQFGPF----SVTLL-EDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMssSAKGPILVHCS
.| |||||||    .   ||      ||. |  . . ||  . |..    | ...  .....  . |||.|||.     . | . |     . |..||||
akikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr..ydtnpvvvhcs

AG
||
aG
subfamily_ptpA1_pd Subfamily ptpA1 1269-1487 2.8e-31 103.7 In-house 9-239 (418) alignment 
Range on Protein: 1269-1487
Range on HMM: 9-239/418.0
SLNDLGNHVACCHSdsnayFSEQFKDLY-SGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLK-LPGVAQHEYINASYIHGySKARKFIAAQGPMKKTL
|. .| ||. | |        |.|. |  |    . | | .  |   ||. ||.| .   . || .      .|||| || | .  ..||..|||. .|.
siynlknhikcihk.....ikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpnti

VDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCL---------NEIEQFGPFSVTLLEDYVMPDY--VIRNISVTLQdgsGEVHALTQYHLTTWPDH
 ||| ..|...   .|||.   |. . ||..|||. .         |  | || .|| |.|    |.   . ||| .|..   || . .|||.   ||||
adfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe...getrditqyqyegwpdh

GVPEYATPLMTLHK-------R-VMSSSAKGPILVHCSAG
 .|... |.  | .       . . ||  . ||.||||||
nipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag
subfamily_PTPRD_pd Subfamily PTPRD 1490-1599 1.6e-30 101.3 In-house 179-287 (564) alignment 
Range on Protein: 1490-1599
Range on HMM: 179-287/564.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQqKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. ||. . | . ||   ....|..|..| . . . . ||||||||  | |||....|.. ||. |.|..||..|. |||.. ..  | | |||| |.||.
VrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheai

EMYLAINSTY
  .||  .| 
lealacgnte
0041856 (Phosphotyrosine protein) phosphatases II 1311-1488 2.3e-30 100.9 In-house 1-120 (182) alignment 
Range on Protein: 1311-1488
Range on HMM: 1-120/182.0
NKPLNRFRNIVPYDDNIitlklpgvaQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTnlvedsktkCEQYWPqclneieqfg
|...||...|.||| ..            ||||... |. .|..|||.|||...|. ||. ......  ..|.||         .|.|||          
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

pfsvtlledyvmpdyvirnisvtlqdgSGEVHALTQYHLTTWPDHGVPEyATPLMTLHKRVMSssAKGPILVHCSAGW
                           . . .. .||. . |||||||.    |  . ..| .   .||.||||||| 
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1489-1599 3.4e-30 100.3 In-house 186-296 (298) alignment 
Range on Protein: 1489-1599
Range on HMM: 186-296/298.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
...|.... | . || .  ..||.....|   ||. |  |..|.||. | |.| ..||.  ||. |.| ||||||| |.|....||||.| |||. ||||
evrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyea

LEMYLAINSTY
   .|.  ...
vlealdsfnde
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1489-1598 3.4e-29 96.9 In-house 179-288 (319) alignment 
Range on Protein: 1489-1598
Range on HMM: 179-288/319.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
....||   | ...| .. ...|... .. . ..|   ||||||||. | ||| .......||. | |||.|||.. . |.  ..  | . |||. ||||
evkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyea

LEMYLAINST
|  .. . .|
lleaveagdt
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1490-1600 1.1e-28 95.1 In-house 139-249 (250) alignment 
Range on Protein: 1490-1600
Range on HMM: 139-249/250.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..|.. . | . || .  ..||.....|   ||..| .|..|.||  |.|.| ..||.  ||. | | |||||.| |.|.. .|.||..||||. .||..
vrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeii

EMYLAINSTYS
  .|   . |.
lkaldsvedya
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1301-1488 1.5e-28 94.2 In-house 27-211 (281) alignment 
Range on Protein: 1301-1488
Range on HMM: 27-211/281.0
KQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL--PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQY
  |.|  . .|.  ||. ||   |   . ||.  |     .|| | ||.     | .| .||| |.|  ||| .||||. ...||| ...|  . || .|
dlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLqdgSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAkgPILVHCSAGW
.|.      ||  .||.  .  |    |   . ..     || . .|..    |||  ||| .  .. . ... . |.  | ..||||| 
fprnahcclqfdklsvsyedstvnkslvttrlnlsy...egetrlithwlwkewpdwqvpessevmlkilrkirarst..ppvihcsagv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1314-1487 1.7e-28 94.3 In-house 51-229 (305) alignment 
Range on Protein: 1314-1487
Range on HMM: 51-229/305.0
LNRFRNIVPYDDNIItlKLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGP--
 ||....   |.| .  || |   |||| | |.   .....|| .| |..||  ||| . .|.|  .. || ||.|    || .|..   ... .|    
knrykdvgcldnnrv..klegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekg

--FSVTLL----EDYV-MPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVmsSSAKGPILVHCSAG
   || .      ...   . ....  ....   ....  |.||   ||| |||   . .. | ..    ..|||| ||||||
qkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka..rpskgpivvhcsag
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1490-1600 2e-28 94.4 In-house 177-287 (318) alignment 
Range on Protein: 1490-1600
Range on HMM: 177-287/318.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |...  | . ||. .. ..|... .| . ||| | ||||||||  | ||||..|..| ||. |||..|||||. | |.. ..  | | .||. ||..|
vrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvl

EMYLAINSTYS
  .||   |. 
lealasgdtev
0046845 (Phosphotyrosine protein) phosphatases II 1490-1601 3.2e-27 91.1 In-house 167-282 (284) alignment 
Range on Protein: 1490-1601
Range on HMM: 167-282/284.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQK-IGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEG---VVDVFQVTKALKRSKPGAVTTLEQYITI
. .|....| ..||  .|. .|. ...| . ...  ||||||||||. |.|||...|. ..||| ..||   .|||... | |.. .||.|.|||||. .
vthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv

YEALEMYLAINSTYSN
|||| .||    |. .
yealleylklkltlle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1302-1489 3.6e-27 90.1 In-house 26-215 (285) alignment 
Range on Protein: 1302-1489
Range on HMM: 26-215/285.0
QCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYSKAR-KFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWP
.|.      |  |||. ..   ..  . ||     ...|| ||...   | .  .|..|||. .|| ||| .|.||| | |.||  |.|    ||  |.|
nctytayeanpdlnryadvrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp

QCLNEIEQFGPFSVTLLE--DYVMPDYVIRNISVT-LQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK-GPILVHCSAGWN
. | |. .|| . .|| |  .  .   .. ...|.  .| | |   . . ..  |||.  || | |.. |.| |     |  || ||||||  
eklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvg
0050432 (Phosphotyrosine protein) phosphatases II 1490-1599 7.8e-27 89.8 In-house 199-305 (308) alignment 
Range on Protein: 1490-1599
Range on HMM: 199-305/308.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQqkiGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. .|. ..| ..||  .|. .|. .. | ...   .|||||||||. |.|||...|. ..||| ..|| ||||.. | |.. .||.|.|.|||. .|.||
vthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyral

EMYLAINSTY
 .||    |.
leylklkltk
0036941 (Phosphotyrosine protein) phosphatases II 1490-1598 1.3e-26 89.1 In-house 170-282 (297) alignment 
Range on Protein: 1490-1598
Range on HMM: 170-282/297.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCK---AEGVVDVFQVTKALKRSKPGAVTTLEQYITI
. .|...||  .||  .|...|. |. | ...... .|||..||||. |.|.|...|. ..|.| .    || ||.... | |.. .||||.|||||. .
vthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

YEALEMYLAINST
|||| ..|  . |
yeallellkkklt
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1291-1491 1.4e-26 87.8 In-house 32-237 (310) alignment 
Range on Protein: 1291-1491
Range on HMM: 32-237/310.0
QFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVED
|.. | . .|   .      .   ||. ..|  |.  . ||.     ..|| | |..       || .|||...|..||| .|.||.  |...| . .|.
qyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgee

SKTKCEQYWPqCLNEIEQFGPFSVTLLEDYvMPDYVIRNISVTLQDG---------SGEVHALTQYHLTTWPDHGVPEYATplMTLHKRVMSSSAKGPIL
 . ||  |||  |   | .|   || | .    .. | |..||.              .   ..  .   ||| |||.      |. .|...   .|| .
grpkcvgywp.slgvtetygcirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htvpqrllaqvrhgpcv

VHCSAGWNIV
|||||| . .
vhcsagkdrl
0051299 (Phosphotyrosine protein) phosphatases II 1490-1593 2.3e-26 88.4 In-house 184-286 (288) alignment 
Range on Protein: 1490-1593
Range on HMM: 184-286/288.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. .|....| ..||  .|. .|. . .|.. ..  ||||.|||||. |.|||...|. ..||| ..||.|||... | |.. .||.|.|.|||. .||||
vthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal

EMYL
 .||
leyl
0036282 (Phosphotyrosine protein) phosphatases II 1339-1489 2.6e-26 87.8 In-house 3-116 (174) alignment 
Range on Protein: 1339-1489
Range on HMM: 3-116/174.0
EYINASYIHGYSKARKFIAAQGPMKktlvdFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclneieqfgpfsvtlledyvmpdyvirnisvtlqDGS
 |||||.....   ...|| |||..     || ......  .||||....|. ..|| .|||                                   . .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lre

GEVHALTQYHLTTWPDHGVPEYATpLMTLHKRVMSS---SAKGPILVHCSAGWN
 ...   ||. . |||||||. .. | .. |.| .    . .||.||||||| .
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvg
0047943 (Phosphotyrosine protein) phosphatases II 1490-1593 1.7e-25 85.5 In-house 168-272 (273) alignment 
Range on Protein: 1490-1593
Range on HMM: 168-272/273.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. .|.. || ..||  ..  .|. |..| . .... ..||.|||||. |.|||...|. ..|.| ..|| |||... | |.. .||.|.|.|||. .|||
vthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyea

LEMYL
| .||
lleyl
0039614 (Phosphotyrosine protein) phosphatases II 1490-1596 2.1e-25 85.2 In-house 185-292 (297) alignment 
Range on Protein: 1490-1596
Range on HMM: 185-292/297.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. .||..||  .||  .....|.... | .....  .|||..||||. |.|||...|. ..|||.. || |||... | |.. .||||.|..||. .|.|
vthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda

LEMYLAIN
| ..|  .
llellkrk
0040438 (Phosphotyrosine protein) phosphatases II 1490-1599 3.4e-25 84.4 In-house 174-282 (317) alignment 
Range on Protein: 1490-1599
Range on HMM: 174-282/317.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkiG-GGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. .|. .||  .||  .|...|. .. | . ..  . |||..||||. |.|||...|. ..|||.. || |||... | |.. .||||.|.|||. .|.|
vthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda

LEMYLAINSTY
| .||  . |.
lleylkrkltl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1297-1487 3.9e-25 83.4 In-house 19-202 (267) alignment 
Range on Protein: 1297-1487
Range on HMM: 19-202/267.0
SGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDsktKCE
| .  ..|  .   |.  ||. . .||||... |.     ..|||||||..|| . ..||. |.|.|.|  ||. .| ..| . .|.||.  .|   .  
sdtsstisqsiaeknqernrlddnlpyddtrvilr...tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nir

QYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgeVHALTQYHLTTWPDH-GVPEYATPLMTLHKRVMSSSAKGPILVHCSAG
..||  . . ...  ..|    .    || |  . . ... |   | .| |.   |        |  ||. .  .     .  |..|.||.|
lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknes..ahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdG
DSPc_SM00195 1490-1593 5.2e-25 83.6 In-house 160-262 (263) alignment 
Range on Protein: 1490-1593
Range on HMM: 160-262/263.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |.|. .| . ||  ... ||...  | ......  ||||||||. |.|||....|.|.|.....|  ||.|.. |.|. ..||.|.|||||..||||.
vtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeai

EMYL
  |.
leyi
PTPc_SM00194 1490-1593 5.2e-25 83.6 In-house 160-262 (263) alignment 
Range on Protein: 1490-1593
Range on HMM: 160-262/263.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |.|. .| . ||  ... ||...  | ......  ||||||||. |.|||....|.|.|.....|  ||.|.. |.|. ..||.|.|||||..||||.
vtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeai

EMYL
  |.
leyi
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1341-1507 6.8e-25 82.4 In-house 78-245 (301) alignment 
Range on Protein: 1341-1507
Range on HMM: 78-245/301.0
INASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLE-DYVMPDYVIrNISVTLQDGSG
| | .|    ....|||.|||.|.|  ||| .. | .   .|||.. ||. ..|||.| |.  .|  . | |.... . .... . .. . .. ..| .|
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkis.krtlevedstg

EV--HALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSsaKGPILVHCSAGWN-IVQFQVIGWMNDGVLRDP
..  ...| |  ..|.|.|||.  . |. | . |  |  . ||.||||||    | |    ..   |. ||
kfatrtvthyqysewtdrgvPkshaelfdlmelvkks..ekPivvhcsaGiGrsvafigteylareveadp
subfamily_PTPRA_pd Subfamily PTPRA 1490-1593 7.8e-25 82.4 In-house 193-295 (330) alignment 
Range on Protein: 1490-1593
Range on HMM: 193-295/330.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGgPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. ||   .| . ||  .|. .|...  | . .|. .| |||||||  | ||| .....  ||. |||..||||.. | |.  .|  | |.|||  ||..|
vrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvl

EMYL
  | 
leyy
0043336 (Phosphotyrosine protein) phosphatases II 1490-1592 1.2e-24 82.7 In-house 175-276 (278) alignment 
Range on Protein: 1490-1592
Range on HMM: 175-276/278.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..... .||. .||  .. ..|. . .|.....   .||..||||. |.|||...|. ..||| . || ||.... | |.. .||||.|..||. .||||
vthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

EMY
 .|
ley
0045450 (Phosphotyrosine protein) phosphatases II 1490-1593 1.3e-24 83.0 In-house 197-304 (307) alignment 
Range on Protein: 1490-1593
Range on HMM: 197-304/307.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPGAVTTLEQYITI
. .|. .|| ..||  .. ..|. |. | . ...  .|||..||||. |.|||...|. ..|.| ..||.   ||.... | |.. .||||...|||. .
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

YEALEMYL
|||| ..|
yeallell
0043147 (Phosphotyrosine protein) phosphatases II 1338-1489 1.9e-24 81.8 In-house 5-112 (172) alignment 
Range on Protein: 1338-1489
Range on HMM: 5-112/172.0
HEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLvedsktkceqywpqclneieqfgpfsvtlledyvmpdyvirnisvtLQDG
. ||||||...| . ..||| |||.  || ||| ......   .|.||.|                                              | |.
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydp

SGEVHALTQYHLTTWPDHGVPeYATPLMTLHKRVMS---SSAKGPILVHCSAGWN
.....   ||. . |||||||  .  |. . . . .    | .||.|||||||..
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvg
Y_phosphatase Protein-tyrosine phosphatase 1491-1589 3.2e-24 81.0 Pfam-A 136-233 (235) alignment 
Range on Protein: 1491-1589
Range on HMM: 136-233/235.0
VQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQqKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
 |... .| . || ..|. .|..|..| ... .   ||.|||||. |.|||...|..|.|||..||. |||.|. | |....||.|..||||| .|.|.
kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1491-1589 3.2e-24 81.0 In-house 136-233 (235) alignment 
Range on Protein: 1491-1589
Range on HMM: 136-233/235.0
VQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQqKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
 |... .| . || ..|. .|..|..| ... .   ||.|||||. |.|||...|..|.|||..||. |||.|. | |....||.|..||||| .|.|.
kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0040439 (Phosphotyrosine protein) phosphatases II 1490-1593 4.3e-24 80.9 In-house 142-246 (249) alignment 
Range on Protein: 1490-1593
Range on HMM: 142-246/249.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. ..|...|  .||  .. ..|. |. | . ....  |||..||||. |.|||...|. ..||| . |. ||.... | |.. .||||...|||. .|||
vlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea

LEMYL
| ..|
llell
subfamily_PTPRK_pd Subfamily PTPRK 1490-1593 4.4e-24 79.9 In-house 175-278 (314) alignment 
Range on Protein: 1490-1593
Range on HMM: 175-278/314.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKiGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA-
. ||| .|| . .|    ...|...  | . |.. . |.||||||    |||...||.| |.  . |||||||.. |.|. .|.  | | |||. ||.. 
vrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

LEMYL
||  |
leacl
0046846 (Phosphotyrosine protein) phosphatases II 1339-1488 4.7e-24 80.5 In-house 13-120 (176) alignment 
Range on Protein: 1339-1488
Range on HMM: 13-120/176.0
EYINASYIHGYskarKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclneI----Eqfgpfsvtlledyvmpdyvirnisvtl
 ||||..| |.    ..|| |||. .|| ||. ......   ||.||..|| .. || .|||.    .                                
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi...........................

qdgsgevhaltQYHLTTWPDHGVPEYaTPLMTLHKRVMSSSAKG-PILVHCSAGW
           ||. . |||||||.. . |..| . . .   .| |.||||||| 
...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1311-1488 5.1e-24 79.4 In-house 55-232 (305) alignment 
Range on Protein: 1311-1488
Range on HMM: 55-232/305.0
NKPLNRFRNIVPYDDNIITLKLPGvaQHEYINASYIHGY-SKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQF
..  ||....   | ... |. |     .|| | |.       ..||.||||. .|. .|| .. |.|   .||| . ||  | || |||| .  |  ..
aitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

GPFSVTLLEDYVMP---DYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVmsSSAKGPILVHCSAGW
    |        |   |  |.   . |    ..  .. . . | ||| |||      . |   .    .| ||.|||||| 
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai..rgskvpivvhcsagi
0049260 (Phosphotyrosine protein) phosphatases II 1345-1489 5.9e-24 79.9 In-house 1-101 (152) alignment 
Range on Protein: 1345-1489
Range on HMM: 1-101/152.0
YIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWpqclneieqfgpfsvtlledyvmpdyvirnisvtlqdgsgevhal
.|.|| . ..|||.|||.  || ||| .... .   .||||.|.|. | |||||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

tQYHLTTWPDHGVPEYATPLMTLHKRVMS--SSAKGPILVHCSAGWN
 ||. . |||||||. .  |. |.. .     . .||.||||||| .
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvg
PTPc_DSPc_SM00012 1490-1589 9.2e-24 79.0 In-house 2-103 (105) alignment 
Range on Protein: 1490-1589
Range on HMM: 2-103/105.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIG-GGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRSKPGAVTTLEQYITIYE
. .... || . || ...  .|.....| . ..|.. ..|.|||||. |.|||...|..|.|.|...| . ||.||. |.|....||.|.|.|||. .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AL
||
al
0049772 (Phosphotyrosine protein) phosphatases II 1305-1489 1.1e-23 79.9 In-house 40-224 (314) alignment 
Range on Protein: 1305-1489
Range on HMM: 40-224/314.0
VGLNGMNKPLNRFRNIVPYDdNIITLKLPGVAQHEYINASYIHGYskaRKFIAAQGPMKKTLVDF----------WCLI--WQEKPASVVM---------
|.   .|.  ||. .|.|.| |   |.  .|  . ||||||..|.   .||||.|||.. |.|||          | ..  .. ..  .||         
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTNLVEDSktkceQ-YWPQCLNEIEqfgpfsvtllE-----DYVmpdyvirnisvtlqdgsgeVHALTQYHLTTWPDHGVPeYATPLM
            |..| .         .... | ...          |     ...                    ..  .|. . .||...|     . 
lsrLdaAlgKtpllildgng.....neptaadlellk..........eelydpelf...................erlgikylripvpDgsap.lledfd

TLHKRVMSSSAKGPILVHCSAGWN
 . . . . ...||.||||.||..
eflefieeadkggpvlvHCkaGkg
0042113 (Phosphotyrosine protein) phosphatases II 1490-1593 3.3e-23 77.8 In-house 140-243 (245) alignment 
Range on Protein: 1490-1593
Range on HMM: 140-243/245.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..... ..|  .||  .....|.... | . ... ..||..||||. |.|||...|. ..||| ..|. |..... | |.. .||||.|..||. .||||
vihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal

EMYL
 ..|
lell
subfamily_Ptp69D_pd Subfamily Ptp69D 1489-1595 3.6e-23 77.1 In-house 183-288 (307) alignment 
Range on Protein: 1489-1595
Range on HMM: 183-288/307.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
..||..  || .  | . .|..|..|. | . ...   .|||||||  |.|.|.. |... |.|.|||  ||.|...| |.. ..  |. ||||. .| |
kvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyra

LEMYLAI
|  |   
lldyssy
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1314-1487 4.9e-23 76.6 In-house 46-214 (288) alignment 
Range on Protein: 1314-1487
Range on HMM: 46-214/288.0
LNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFS
 .|..|.   |   . |.      . ||.|  .      |..| || |.. |.  .| .. ..    .|||..|.|  | | ..|.|  | |  ..| . 
rdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlc

VTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVmsSSAKGPILVHCSAG
    ....  | ...   .  .    |   . . ||  |.|.||||   . . | ...   | . ||.||.|||
tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqkPivvhssaG
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1490-1591 2e-21 71.2 In-house 164-265 (283) alignment 
Range on Protein: 1490-1591
Range on HMM: 164-265/283.0
IVQFQVIGWMNDGVlRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
.  .|||.|.. |    .   |  .. ||  |..   |||||||| .. ||.|..|.| .... ..| |||||.| | ..  ...|| ||.||  ..|. 
lahyqvidWleyge.qaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

-EM
 | 
leq
0045098 (Phosphotyrosine protein) phosphatases II 1489-1594 4.7e-21 70.8 In-house 155-273 (278) alignment 
Range on Protein: 1489-1594
Range on HMM: 155-273/278.0
NIVQFQVIGWMNDGVLRDP--RTVLQVIDDVIHRQQK------------IGGGPIVVHCSDTVSRTGVYCAISIALEQCkaEGVVDVFQVTKALKRSKPG
.. ... ..|   ||  .|  . .|.... . .....             .|||..||||  |.|||...|. . ||..  ||.||.... | |.. .||
gvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpg

-AVTTLEQYITIYEALEMYLA
 ||..||||. .||.| ..| 
lavqnleqyrflyefllelll
subfamily_PTPN6_pd Subfamily PTPN6 1489-1599 5.4e-21 69.9 In-house 187-303 (306) alignment 
Range on Protein: 1489-1599
Range on HMM: 187-303/306.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIG---GGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPGAVTTLEQY
...|..   | . || .|| .||. ..|| ..|...     ||||||||. . ||| .  | | |.. . .|.   .|. .. | ... . | | | .||
evfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqy

ITIYEALEMYLAINSTY
  .|.|...|.  ....
kfvykaikkyietkkkl
0037934 (Phosphotyrosine protein) phosphatases II 1490-1592 1.9e-20 68.9 In-house 135-241 (243) alignment 
Range on Protein: 1490-1592
Range on HMM: 135-241/243.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQK-------IGGGPIVVHCSDTVSRTGVYCAISIALEQCkaeGvVDVFQVTKALKRSKPG-AVTTLEQ
..... ..|   ||  .|  .|. .|.|.  ...        .|||..||||  |.|||...|. . |...   | ||.... | |.. .|| ||.|..|
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsq

YITIYEALEMY
|. .|||| ..
yrflyeallel
subfamily_CG7180_pd Subfamily CG7180 1491-1597 2e-20 67.6 In-house 183-294 (296) alignment 
Range on Protein: 1491-1597
Range on HMM: 183-294/296.0
VQFQVIGWMN-DGVLRDPRTVLQVIDDVIHRQQKI----GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITI
 .||.  |   | |     ......  |   ..|.      ||.||..|| .||.|||.|| ..||. . |. ||||.  | |.||.|. | . |.|  |
klfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyi

YEALEMYLAINS
|. |. ..  | 
Ydvlleavlcnk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1490-1595 2.4e-20 67.9 In-house 180-291 (325) alignment 
Range on Protein: 1490-1595
Range on HMM: 180-291/325.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-----GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYIT
. |||. .| . || . | |.. ... | . ....     . .||.||||. | ||||. ..  ||..   |  ||.|.. | |.. .|  | | .||| 
vkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyil

IYEALEMYL-AI
|||||  .. . 
iyealveaymsg
subfamily_PTPRG_pd Subfamily PTPRG 1490-1594 5.4e-20 66.1 In-house 185-288 (563) alignment 
Range on Protein: 1490-1594
Range on HMM: 185-288/563.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDViHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |..   | . ||   .  ||. .     . .|   ||||||||  |.|||.|....  |.| ..| .|.||.. | ..  ..  |.| |||| ...||
vrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal

EMYLA
   .|
leaia
subfamily_egg_pd Subfamily egg 1321-1487 5.7e-20 66.2 In-house 50-211 (307) alignment 
Range on Protein: 1321-1487
Range on HMM: 50-211/307.0
VPYDDNIITLKLP-GVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDskTKCEQYWPQCLNEIEQF--GPFSVTLL
   |   ..|.|. |    ..| | ...|     .|| || |.| |  ||| ...||.   .||||  .|    .|| |||.. ..  ..  | . .. |
hckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienl

EDYVMPDYVIRNISVTLQDGSGEVHALTQYHlttWPDHGVPEYATPLMTLHKRVmssSAKGPILVHCSAG
. .  .| . |   . |  |  |   |  .    .  . . .  .||  | |      .  |..|..  |
kvdskadplfrvtklklvGgddeerflehwq...gdvnnssdvysplrvlrklr...nlskpvvvqdilG
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1489-1593 1.5e-19 65.1 In-house 176-280 (315) alignment 
Range on Protein: 1489-1593
Range on HMM: 176-280/315.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGgGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
..||...  | . || .   .....|  |   ...   |.||||||. | ||| .....  |.| .|| ..||... . ... . ..| ..|||  ||.|
evvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda

L-EMYL
| | ..
lletfv
0044763 (Phosphotyrosine protein) phosphatases II 1331-1489 2.7e-19 65.0 In-house 11-122 (178) alignment 
Range on Protein: 1331-1489
Range on HMM: 11-122/178.0
KLPGVAQHEYINASYIHGYskarKFIAAQGPmkktlVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNeieqfgpfsvtlledyvmpdyvirni
.|.|.   .|||||.| ..     ......|     .|.. |.....  ..|.||. .|  . || .|||.  .                          
nleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..........................

svtlqdgsgevhalTQYHLTTWPDHGVPEYATPLMTLHKRVMSS--SAKGPILVHCSAGWN
               ||. . .||||||.    .. ... . .   . .||.|||||||..
..............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1489-1589 4.1e-19 64.0 In-house 186-287 (319) alignment 
Range on Protein: 1489-1589
Range on HMM: 186-287/319.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGG-GPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
.| ||   || . ||   |  ...... | | ..|  .  .||||||  | ||||| .. . |.. | |  |||... . |.. ..  |  | ||  || 
kitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

AL
||
al
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1489-1590 4.3e-19 63.6 In-house 176-276 (288) alignment 
Range on Protein: 1489-1590
Range on HMM: 176-276/288.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
.| |.|  .| ..|| .. . .|.... |   .|.   |||.||||. | |||.. |.  .... ..| ..||. . . |.....  | ||.||. |||.
eitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyev

LE
| 
ll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1491-1598 5.4e-19 63.4 In-house 180-289 (297) alignment 
Range on Protein: 1491-1598
Range on HMM: 180-289/297.0
VQFQVIGWMNDGVLR--DPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
 |.| . | .. | |  . ...|..|..| .  ..   ||..|||.  | ||||...|   . . | |  ||.|.. | |....|  | | |||  .|.|
kqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyva

LEMYLAINST
.  .|  . |
vleallsedt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1490-1597 6e-19 63.0 In-house 175-281 (315) alignment 
Range on Protein: 1490-1597
Range on HMM: 175-281/315.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRqQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |||  .| . || ..  ..|..| .|    ..    ...||||  | |||| ..|   ..| | . .||||.. | |.. .|  | | |.|  ||.|.
vtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydav

EMYLAINS
  .|    
ledllwrn
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1497-1593 6.4e-19 63.1 In-house 170-268 (274) alignment 
Range on Protein: 1497-1593
Range on HMM: 170-268/274.0
GWMNDGVLRDPRTVLQVIDDVIHRQQKI--GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALEMYL
 | .  . .|..|.|.....| . ...     .|.|||||  . |||.. |||||. | ..|.||||....  |.  . | | | |||  |..|| .||
dWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1490-1596 6.7e-19 62.4 In-house 174-279 (515) alignment 
Range on Protein: 1490-1596
Range on HMM: 174-279/515.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGgGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. ||.  .| . || .. ...|..| .|   ....   |...|||  | ||||...|   . . |   .||||.. . ... .|  | | |||  ||.|.
vtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav

EMYLAIN
  .|   
ledllwr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1489-1589 6.8e-19 63.4 In-house 150-251 (284) alignment 
Range on Protein: 1489-1589
Range on HMM: 150-251/284.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGG-GPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
.| ||   || . ||   |  ...... | | ..|  .  .||||||  | ||||| .. . |.. | |  |||... . |.. ..  |  | ||  || 
kirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

AL
||
al
0051082 (Phosphotyrosine protein) phosphatases II 1339-1489 1.3e-18 62.5 In-house 4-104 (151) alignment 
Range on Protein: 1339-1489
Range on HMM: 4-104/151.0
EYINASYIHGYskarkFIAAQGPMKktlvDFWCLIWQEKPASVVMLTNLVEDSktKCEQYWPQCLneieqfgpfsvtlledyvmpdyvirnisvtlqdgs
 |||.||. |.     ... .||.     ||. |.....  ..|.|....|    .| .|.|.                                     
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

gevHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSsSAKGPILVHCSAGWN
   . ....... |||.|.|..   .. ... ...   .||.|||||||..
...ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1297-1401 1.7e-18 61.5 In-house 35-152 (350) alignment 
Range on Protein: 1297-1401
Range on HMM: 35-152/350.0
SGNDKQCSVGLNGMNKplNRFRNIVPYDDNIITLK----L-----PGVAQHEYINASYIHGY----SKARKF--IAAQGPMKKTLVDFWCLIWQEKPASV
  || . | |.. . |  ||..||.||. . . ||            .   .||||.|..      .   .|  ||.|.|...|. ||. .| . |   .
psnDvilseGvelfak..nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvi

VMLTNLVEDSKTKCEQYWPQ
..||..||    ||..||..
lsltsdvelnlekcyrYWqe
subfamily_PTPRB_pd Subfamily PTPRB 1490-1593 2.7e-18 61.1 In-house 181-285 (293) alignment 
Range on Protein: 1490-1593
Range on HMM: 181-285/293.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQ-QKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. |.. . | . ||  ...|.|. .  | ... ..   .|||||||  | |||.. |.   |.. . | .||.| .  .|....   | | .||| |...
vrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqc

LEMYL
.  .|
vldll
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1301-1489 3.8e-18 60.2 In-house 35-221 (312) alignment 
Range on Protein: 1301-1489
Range on HMM: 35-221/312.0
KQCSVGLNgmNKPLNRFRNIVPYDDNIITLKlpGvAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWP
 .|.  |.   | |||. ||  .|   .||   |  .  || | ...  .|  .|...|||...| . || |      .|...|. .|||.  || .|  
sectaflk..fkdlnrypniqcwdrgrftla..g.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyis

QCL--NEIEQFGPFSVTLLEDY---VMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMssSAKGPILVHCSAGWN
. .   ..|.   ..    |        | .   .   .   .|.   | .|  ..|||||.|.     . |   |     | |.. |||||  
divgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk..kdkkpviahcsagvg
subfamily_PTPN12_pd Subfamily PTPN12 1489-1592 1.4e-17 58.5 In-house 171-276 (290) alignment 
Range on Protein: 1489-1592
Range on HMM: 171-276/290.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPGAVTTLEQYITI
.. ||.   | . || . . ..|..|..| ..|.     |.|||||  | |||. .|| .. |. ||| .   .|||..   |.. .. .| | |||  .
kvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelv

YEALEMY
|.|.. .
ykavael
0036282 (Phosphotyrosine protein) phosphatases II 1490-1587 2.1e-17 58.8 In-house 69-164 (174) alignment 
Range on Protein: 1490-1587
Range on HMM: 69-164/174.0
IVQFQVIGWMNDGVLRDPRtVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKaEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
..|.. ..|  .||  ..  .|.... | . ... .|||..||||  |.|||. .|. . | . . |..||.... ..|.. .||.|.| .||. .|.
giqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0051429 (Phosphotyrosine protein) phosphatases II 1490-1594 2e-16 56.0 In-house 122-226 (272) alignment 
Range on Protein: 1490-1594
Range on HMM: 122-226/272.0
IVQFQVIGWMNDGVLRDPrtVLQVIDDVIHrqqkigGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVD--------VFQVTKALKRSKPGAVTTLEQ
. ... ..|  .|| ...  .|.... . .      |||..||||  ..|||...|. . |..  .| .||        .... . |..  |||| | ||
vmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeq

YITIYEALEMYLA
|. .||||  .| 
ylflyeallellr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1490-1591 2.8e-16 53.9 In-house 91-192 (440) alignment 
Range on Protein: 1490-1591
Range on HMM: 91-192/440.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |..  || . || .    ||..|.|| . |.| | ||..||||  ..||||  |.   | ..|    .|.| . .... ..|  | | |||  ..||.
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

EM
  
le
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1338-1487 3.9e-16 54.0 In-house 46-201 (290) alignment 
Range on Protein: 1338-1487
Range on HMM: 46-201/290.0
HEYINASYIHgYSKARKFIAAQGPMKKT-------LVDFWCLIWQEKPASVVMLTNLVEDSKT----KCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYV
 .|| |...  ...  ..|. | | .|.       . .|| .. |||  .|||| .  | |.      |..| |.  .|. .|. ..|   .     |  
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

IRNISVTLQDGsgEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMssSAKGPILVHCSAG
.|.. |. .|.  | . .| . |  | .  |.|    |..| . |.    | |..|||  |
tRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdG
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1365-1487 4.1e-16 53.8 In-house 40-158 (255) alignment 
Range on Protein: 1365-1487
Range on HMM: 40-158/255.0
TLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEdyVMPDYVIRNISVTLQDG-SGEVHALTQYHLTTWPDHGVPEYATP
|.  |.  | | |.  ||||... |... ||..|.|  ..|  ..   .||  .   . | |.| . .|.. |   . | .. |. . |...  || |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LMTLHKRVMSSsakGPILVHCSAG
.. . | |  |    ...||||.|
ilnilkvvrds...ksvvvhCstG
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1490-1594 4.9e-16 53.5 In-house 154-265 (270) alignment 
Range on Protein: 1490-1594
Range on HMM: 154-265/270.0
IVQFQVIGWMNDGVLRDPR------TVLQVIDDV-IHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQY
.| |.   | ..|| |..        .|... .|  .....  ..|..||||. | |||.  |. ||..  . .. ||| .. ..|.. ..  | . |||
lvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqy

ITIYEALEMYLA
  .|.|. .|  
eflykavveyae
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1490-1589 7.7e-16 52.6 In-house 176-275 (439) alignment 
Range on Protein: 1490-1589
Range on HMM: 176-275/439.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..||. | | .  |  .   ||. .  .   ..|   ||.|||||  | |||   |. ||||| |.|  ||.  . | |.. .   | .| ||. ||.|.
vlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_PTPN13_pd Subfamily PTPN13 1489-1590 1.2e-15 52.5 In-house 167-266 (273) alignment 
Range on Protein: 1489-1590
Range on HMM: 167-266/273.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkiGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
...... . | . || . .  .||..  | . |.    ||||||||  . |.|.. .| ..|.  . .  .|| .. . |.. . | | | .||| .|.|
evahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyka

LE
. 
il
0041856 (Phosphotyrosine protein) phosphatases II 1490-1595 1.3e-15 53.0 In-house 79-173 (182) alignment 
Range on Protein: 1490-1595
Range on HMM: 79-173/182.0
IVQFQVIGWMNDGVLRdPRTVLQVIDDVIHrqqkiGGGPIVVHCSDTVSRTGVYCAISIALEQckaeGvVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..|.. ..|  .||   ....|. |..|..      |||..||||  |.|||...|. . ...    | |..... | ... .||.|.|..||. .. ||
giqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlal

EMYLAI
 ..|  
lellll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1519-1592 1.6e-15 51.9 In-house 185-258 (267) alignment 
Range on Protein: 1519-1592
Range on HMM: 185-258/267.0
HRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALEMY
. | . |. |.||.||| | |.| .  |   ||. | |||.|.|.  . ..  ..| | |.|.|| |.| |  |
knqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0043147 (Phosphotyrosine protein) phosphatases II 1490-1588 1.9e-15 52.4 In-house 65-156 (172) alignment 
Range on Protein: 1490-1588
Range on HMM: 65-156/172.0
IVQFQVIGWMNDGVLrDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALeqckaeG-VvDVFQVTKALKRSKPGAVTTLEQYITIYEA
..|.. ..|   ||  ... .|.... . .....  |||..||||  |.|||. .|. . |        . ..... . ... .||||.. .||. .|. 
giqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyf
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1489-1593 8.8e-15 49.6 In-house 171-276 (281) alignment 
Range on Protein: 1489-1593
Range on HMM: 171-276/281.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRSKPGAVTTLEQYITIYE
...|.. . | . ||  ... .|.  ..| . ..|    |.|.|||  | |||.| |.  ......||   .|| .| . |....   | |. ||  .| 
eveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvyk

ALEMYL
|.  .|
avldal
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1490-1588 1.9e-14 48.5 In-house 135-234 (237) alignment 
Range on Protein: 1490-1588
Range on HMM: 135-234/237.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
| |.|   | . || .   ..|.   ..|.| ...   || ..|||  | |||..  |   | |.| . |||...  ....  .|  . | .||. |...
ihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1352-1490 5.7e-14 46.7 In-house 4-148 (199) alignment 
Range on Protein: 1352-1490
Range on HMM: 4-148/199.0
ARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDG-SGEVHALTQYHLT
 |..||.| |...|. ||| ..|.     .||. .   . ..    ||| . .   ..| .|||     . |||.|  . .| .         ...| .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPDHGVPEYATPLM-TLHKRVMSS----SAKGPILVHCSAGWNI
.| ..  |. |  .   .  | .|         |..|||| |  .
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgf
subfamily_eak_pd Subfamily eak 1317-1469 5.9e-14 46.2 In-house 57-205 (332) alignment 
Range on Protein: 1317-1469
Range on HMM: 57-205/332.0
FRNIVPYDDNIITLKLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTL
  .||||| . . |      .  ||||| .      ||.| .  . .. .  || .. ..|  ..|.| . ||    | ..|.|.   |  .|| . |. 
vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver

lEDYVMPD-YVIRNIsvTLQDGSgEVHALTQYHLTTWPDHGVPEYATpLMTLHK
  ..|  . .  |..   |. |  | | .  |..  | .  .| |   ...|.|
.kefvkrniletrll..elskGn.ethrvlhykvfGwtettlpkyed.flalrk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1352-1490 6.8e-14 46.5 In-house 3-147 (198) alignment 
Range on Protein: 1352-1490
Range on HMM: 3-147/198.0
ARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDG-SGEVHALTQYHLT
 |..||.| |...|| ||| ..|.     .||. .   . ..    ||| . .   ..| .|||     . |||.|  . .| .         ...| .|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPDHGVPEYATPLM-TLHKRVMSS----SAKGPILVHCSAGWNI
.| ..  |. |  .   .  | .|         |..|||| |  .
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgf
0048076 (Phosphotyrosine protein) phosphatases II 1490-1592 1.1e-13 46.6 In-house 47-142 (145) alignment 
Range on Protein: 1490-1592
Range on HMM: 47-142/145.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKigGGPIVVHCSDTVSRTGVYCAISIALEqckaEGvVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..|.. ..|   ||  .....|.... . . ...  |||..||||  |.|||...|. . |.    .| |..... . ...  ||||.. .|.. .||..
giqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefe

EMY
...
lel
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1490-1588 1.5e-13 45.5 In-house 138-235 (239) alignment 
Range on Protein: 1490-1588
Range on HMM: 138-235/239.0
IVQFQVIGWMNDGVLRDPRTVLQVIdDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. |...  | . || .   .|| .    | ..   |  | |.|||  | ||| .  |   | |.| .  ||.|.  ||..  .|  | | |||. |. |
vyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1490-1588 1.7e-13 45.3 In-house 139-236 (239) alignment 
Range on Protein: 1490-1588
Range on HMM: 139-236/239.0
IVQFQVIGWMNDGVLRDPRTVLQVIdDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. |...  | . || .   .|| .    | ..   |  | |.|||  | ||| .  |   | |.| .  ||.|.  ||..  .|  | | |||. |. |
vyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1267-1360 1.9e-13 44.4 In-house 4-95 (95) alignment 
Range on Protein: 1267-1360
Range on HMM: 4-95/95.0
PISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpGVAQHEYINASYIHGYSKARKFIAAQG
|| .  .  ||   ||.|.  | ..|| .        .||    | | ||| ||.|||   ..|      . .|||| .. ||..   .|||||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt..tkrdsdyinacfvdgyarkncyiaaqg
0046846 (Phosphotyrosine protein) phosphatases II 1492-1592 2.1e-13 45.9 In-house 78-172 (176) alignment 
Range on Protein: 1492-1592
Range on HMM: 78-172/176.0
QFQVIGWMNDGVLRDpRTVLQVIDDVIHRQQKigGGPIVVHCSDTVSRTGVYCAISialeQCKAEGVVDVFQVTKALKRSKP-GAVTTLEQYITIYEALE
|.....|   ||  . . .|.... .  ....  |||..||||  ..|||...|.      .. |  ..|... . ... .| |||.| |||  .||.. 
qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefel

MY
..
ll
subfamily_PTPN9_pd Subfamily PTPN9 1489-1592 3.1e-13 44.4 In-house 174-289 (297) alignment 
Range on Protein: 1489-1592
Range on HMM: 174-289/297.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQ------------KIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAV
... ||...| . || ..  ..|.|.. | ..|             .. | |||||||  . ||| .... |.|.. . .|.|||... | |.  .  ..
kvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsi

TTLEQYITIYEALEMY
 | |||   | |.  |
qtpeqyefcylavley
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1490-1590 4.2e-13 43.4 In-house 134-233 (392) alignment 
Range on Protein: 1490-1590
Range on HMM: 134-233/392.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. ||..  | ...| .   ..|..| .|     .    |...|||  | ||||  .|   . ..|   .||||..   ..| .|  | | |||  || |.
vaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav

E
 
l
subfamily_PTPN3_pd Subfamily PTPN3 1489-1588 4.6e-13 43.7 In-house 172-270 (280) alignment 
Range on Protein: 1489-1588
Range on HMM: 172-270/280.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDViHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
.|.|.| . | . ||  |.  .|.... | .....    |.|||||  . ||||. .. .||    |.  | . .. . ..  .   | | .||  . ||
kilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea
0049260 (Phosphotyrosine protein) phosphatases II 1492-1587 5e-13 44.5 In-house 56-144 (152) alignment 
Range on Protein: 1492-1587
Range on HMM: 56-144/152.0
QFQVIGWMNDGVLRDPRTVLQvIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALeqckaeGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
|.. . |  .||  ..  .|. . ..|.. ..  |||..||||  |.|||...|. . |        |..... . ... .||||.. .|.. .||
qylhlpwpDhgvpdlsqlllf.lllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0051082 (Phosphotyrosine protein) phosphatases II 1488-1589 6.8e-13 44.0 In-house 58-149 (151) alignment 
Range on Protein: 1488-1589
Range on HMM: 58-149/151.0
WNIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHrqqkIGGGPIVVHCSDTVSRTGVYCAISIALEQckaegvVDVFQVTKALKRSKPGAVTTLEQYITIYE
 .........| . |.   . .||.... ...     ..||..||||  ..|||. .|. . |..      |..... . .... ||.|.. .|.. .. 
ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

AL
||
al
fn3 Fibronectin type III domain 594-669 9.8e-13 41.2 Pfam-A 1-79 (85) alignment 
Range on Protein: 594-669
Range on HMM: 1-79/85.0
SAPSSLTEVNKTATTITVNWNALD--SSDADGYVVNVTSDTDT--VQTVQVEGSSNnTITLNGLRAVTNYSITVRAYQQL
|||. |.  . |.|..|..|.. .  ... .|| | . .....   ....|..... . ||.||.. |.|...|.|. . 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_PTPN23_pd Subfamily PTPN23 1490-1589 1.7e-12 41.7 In-house 173-276 (288) alignment 
Range on Protein: 1490-1589
Range on HMM: 173-276/288.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIH---RQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQC-KAEGVVDVFQVTKALKRSKPGAVTTLEQYITI
..  |.  | . ||   | |.||..| | .    .|.    |.|||||  | ||||.. .  |...  | .|..|. || . |.. .   | . ||.   
vshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfs

YEAL
||| 
yeav
0048179 (Phosphotyrosine protein) phosphatases II 1490-1587 1.8e-12 42.7 In-house 49-139 (144) alignment 
Range on Protein: 1490-1587
Range on HMM: 49-139/144.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkiGGGPIVVHCSDTVSRTGVYCAISIALeqckAEGvVDVFQVTKALKRSKPGAVTTLEQYITIYE
..|.. ..| . ||  ..  .|.... . . ..   |||..||||  |.|||...|. . .     .| ...... . ...  ||||.. .|.. ..|
giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_hpo-7_pd Subfamily hpo-7 1364-1487 2.7e-12 41.2 In-house 45-164 (263) alignment 
Range on Protein: 1364-1487
Range on HMM: 45-164/263.0
KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVmpDYVIRNISVTLQDG-SGEVHALTQYHLTTWPDHGVPEYAT
.|.  |.  | | |.  ||||..  |... ||..|.|  ..|  ..   .|.  .     | ... . .. . |   ..| ...|  . |...  || | 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

PLMTLHKRVMSSsakGPILVHCSAG
  . . | .  |    .. ||||.|
eilnilkvarns...kslvvhcstG
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1358-1487 4.3e-12 40.1 In-house 96-231 (302) alignment 
Range on Protein: 1358-1487
Range on HMM: 96-231/302.0
AQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTL------LEDYV-MPDYVIRNISVTLQDGSGEVH-ALTQYHL
   | |.||  .|.|| | . | || |...||| . || .|. . ...  .|| ..|.       ||..    .... .. .. .    .|. ..   . 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TTWPDHGVPEYATPLMTLHKrvMSSSAKGPILVHCSAG
..||||| |. | . . . |     | |  .|||||||
sawpdhGapkeaytaldilk..fcesykknvlvhcsaG
0049772 (Phosphotyrosine protein) phosphatases II 1491-1594 8.5e-12 40.9 In-house 181-281 (314) alignment 
Range on Protein: 1491-1594
Range on HMM: 181-281/314.0
VQFQVIGWMNdGVLRDPRTVLQVIdDVIHRQqkIGGGPIVVHCSDTVSRTGVYCAISIALEQCkaeGVvDVFQVTKALKRSKP-----GAVTTLEQYITI
...  | .   |   ... ..... ..|..     |||..|||.. ..|||..... . . ..   || .. .. . ...  |     |.. .||||. |
ikylripvpD.gsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefi

YEALEMYLA
.|||..|| 
lealleylk
PTPc_DSPc_SM00012 1445-1489 4.6e-11 38.2 In-house 3-51 (105) alignment 
Range on Protein: 1445-1489
Range on HMM: 3-51/105.0
TQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK----GPILVHCSAGWN
..|| |.||||||||.......| . |...  |    .|..||||||..
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvg
subfamily_PTPN14_pd Subfamily PTPN14 1490-1593 6.7e-11 36.7 In-house 185-296 (300) alignment 
Range on Protein: 1490-1593
Range on HMM: 185-296/300.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDV---I-HRQQKI----GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQ
.. .| . | ..|| .|... |. ...|     . ....       |..||||. | ||||     . ..  . . ..|. .| . |.. .   | || |
vwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaq

YITIYEALEMYL
|  .|..|  ||
YkfvYkvlikyl
subfamily_PTPRN_pd Subfamily PTPRN 1490-1588 6.7e-11 36.4 In-house 189-287 (297) alignment 
Range on Protein: 1490-1588
Range on HMM: 189-287/297.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIhRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQC-KAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. ||  . | . ||   ....|.    |  .  .    |||||||| . |||||..| . |..  |    .|.    . |.  .|| | | .|.  .. |
vtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1347-1415 9.9e-11 35.6 In-house 230-294 (440) alignment 
Range on Protein: 1347-1415
Range on HMM: 230-294/440.0
HGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEdsKTkCEQYWPQCLNEIeQFGPFSVT
.||||   |||.| |.  |..||| |. . . ....|| .| .  || |  |||     .  ||||.| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd..kt.csiywpvntrsv.tfgpftvg
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1490-1597 1.1e-10 35.8 In-house 170-281 (287) alignment 
Range on Protein: 1490-1597
Range on HMM: 170-281/287.0
IVQFQVIGWmNDGVLRDP-----RTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYIT
. |.... |  |.||        | ||.| . .  ...  . ||.|||..  . |.|.. |. . ... .  | ||| .|   |.  . . | .  |.  
vkqldllsw.PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrl

IYEALEMYLAINS
.||||  |   | 
lyealvtyyktnp
0044763 (Phosphotyrosine protein) phosphatases II 1492-1596 1.1e-10 36.9 In-house 77-174 (178) alignment 
Range on Protein: 1492-1596
Range on HMM: 77-174/178.0
QFQVIGWMNDGVLRDPRTVLQVIdDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQckaeGVvDVFQVTKALKRSKPgAVTTLEQYITIYEALEM
|.. |..  .||   .. .|... . |.. ..  |||..||||  |.|.|. .|. . ...    |. ..... . ... .| .|.. .|.  .||  ..
qylhipipDhgvpdllehflefv.efieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr

YLAIN
.|. .
llkes
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1334-1401 3.3e-10 33.8 In-house 86-155 (349) alignment 
Range on Protein: 1334-1401
Range on HMM: 86-155/349.0
GVAQHEYINASYIH--GYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQ
.   ..|||| |..   .|  .|.|| | |.  |. ||. .|  ..   |. |..  | |  ||..|| .
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
0048076 (Phosphotyrosine protein) phosphatases II 1407-1488 1e-09 33.8 In-house 11-92 (145) alignment 
Range on Protein: 1407-1488
Range on HMM: 11-92/145.0
EQFGPFSvTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSA-KGPILVHCSAGW
  .|..  | |.   . |. |. .     . .....  .||. . |||||||. .  |... . . .  . .||.||||||| 
lylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1526-1587 1.3e-09 32.5 In-house 134-197 (198) alignment 
Range on Protein: 1526-1587
Range on HMM: 134-197/198.0
GGPIVVHCSDTVSRTGVYCAISIALE---QCKaEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
  |..|||||    |||. |. | .    . |   |||.|.|.| |.... | ...|..|  ||.
dapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1526-1587 1.4e-09 32.5 In-house 135-198 (199) alignment 
Range on Protein: 1526-1587
Range on HMM: 135-198/199.0
GGPIVVHCSDTVSRTGVYCAISIALE---QCKaEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
  |..|||||    |||. |. | .    . |   |||.|.|.| |.... | ...|..|  ||.
dapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1529-1590 1.4e-09 32.2 In-house 1-62 (69) alignment 
Range on Protein: 1529-1590
Range on HMM: 1-62/69.0
IVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALE
.|||||    ||| . || . . . |.| .||.|   . ... .|  |    .|| |..|| 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1494-1590 1.7e-09 31.7 In-house 189-280 (290) alignment 
Range on Protein: 1494-1590
Range on HMM: 189-280/290.0
QVIGWMNDGVLRDPRTVLQVIDDVihrqqKIGGGPIVVHCSDTVSRTGVYCAISIALeQCKAEG-VVDVFQVTKALKRSKPGAVTTLEQYITIYEALE
... | .  |     ..|...  .     .   ||.|||||  . ||| . || ..| |.  .|  .|. .. .||..|. ..|    ||... |.| 
kikswpdksvalstlallrtlril.....rkasGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveill
fn3 Fibronectin type III domain 1065-1132 2.3e-09 30.4 Pfam-A 1-76 (85) alignment 
Range on Protein: 1065-1132
Range on HMM: 1-76/85.0
DPPNNVTGFVINTNSIKVNWTNS----TETNGYVIEYTTGGGTR--NVVSTSEDE--IVLTNLSPMSTYTISVYSY
..| |..   ....|. ..|. .     .  || .|| . ||..  . .......   .||.| | ..|...|...
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1307-1457 2.3e-09 31.3 In-house 92-235 (244) alignment 
Range on Protein: 1307-1457
Range on HMM: 92-235/244.0
LNGMNKPLNRFRNIVPYDDNIITLKLpGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNlVEDSktkcEQYWPQClNEI
.|  |   ||    .|.| | . |   |     |||||..    .. ..| .| |.  | .||| .. . .   .|.|   ||.     ..|||.  . .
fnpnnswknregaglpfdfnrvplsk.gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywpds.epl

EQFG-PFSVTLLEDYVMPDYVIRNISVTlQDGSGEVHALTQYHLTTWPDHGV
| .    .||| .   . .    |. .   |      ||| . .. ||  | 
ewyeeditvtltdrdefknikasnleie.sdmneshqaltmfqisnwpsdgt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1490-1595 3.7e-09 30.8 In-house 217-346 (350) alignment 
Range on Protein: 1490-1595
Range on HMM: 217-346/350.0
IVQFQVIGWMNDGVLRDPRTVLQVID---DVIH----R--QQKIGGGPIVVHCSDTVSRTGVYCAISIALE------Q---------CKAEgVVD-VFQV
. |.||  | . ..| .|. .||...   |.|     .   ..  . ||.||||  | |||.....   |.      .           |. . | ....
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDlisii

TKALKRSKPGAVTTLEQYITIYEALEMYLAI
 . |.. .   | .|.|.| |||||  | |.
vnelrkqrismvqnldqfifiYeallfyfaL
0048179 (Phosphotyrosine protein) phosphatases II 1436-1489 7.2e-09 31.0 In-house 41-95 (144) alignment 
Range on Protein: 1436-1489
Range on HMM: 41-95/144.0
DGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSS-SAKGPILVHCSAGWN
.   . .  .||. . |||||||.... | .. . . .  . .||.||||||| .
epefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvg
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1530-1590 8.2e-09 29.7 In-house 1-61 (69) alignment 
Range on Protein: 1530-1590
Range on HMM: 1-61/69.0
VVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALE
|||||    ||| . || . . . |.| .||.|   . ... .|  |   ..|. |..|| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1480-1596 1.7e-08 28.2 In-house 210-347 (349) alignment 
Range on Protein: 1480-1596
Range on HMM: 210-347/349.0
ILVHCSAGWNIVQFQVIGWMNDGVLRDPRTVLQV-------IDDVIHRQ--QKIGGGPIVVHCSDTVSRTGVYCAISIALE--QCKAEG--VV-------
||.  .  . ..|.||  |.. ..| .| ..||        |||   |.  ..    ...||||    ||||.. . . |.  .   .    .       
illavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallk

-DVFQVTKALKRSKPGAVTTLEQYITIYEALEMYLAIN
  .. .   |.. .   |  | |.|.|||||  |.|..
DlisiivnelrkqrismvqnlaqfiaiyealLkyfalk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1440-1487 3.7e-08 27.1 In-house 87-137 (440) alignment 
Range on Protein: 1440-1487
Range on HMM: 87-137/440.0
EVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS---AKGPILVHCSAG
| ..| |||   |||.|||..| |.. . . |  |    ..||.|||||||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsag
subfamily_PTPN1_pd Subfamily PTPN1 1489-1588 8.8e-08 26.2 In-house 163-266 (290) alignment 
Range on Protein: 1489-1588
Range on HMM: 163-266/290.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQ-KIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPGAVTTLEQYIT
.|..|  . | . || . | . |. . .| .    .   || |.|||  . |.| .| .   | . ....    ||. .|  .|.. . | . | .|   
eilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrf

IYEA
 | |
syla
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1497-1595 1.1e-07 26.2 In-house 180-273 (288) alignment 
Range on Protein: 1497-1595
Range on HMM: 180-273/288.0
GWMNDGVLRDPRTVLQVIDDViHRQQKigggPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALEMYLAI
 | .|||  .  . |.... . .  ||    |||||.|  | |||    | ||||. . .  . . .. . |. ..  |..|  ||. ..  .  .|..
eWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1494-1586 1.3e-07 26.1 In-house 164-252 (290) alignment 
Range on Protein: 1494-1586
Range on HMM: 164-252/290.0
QVIGWMNDGVLRDPRTVLQVIDDVIHRQqkiggGPIVVHCSDTVSRTGVYCAISIALEQCK-AEGVVDVFQVTKALKRSKPGAVTTLEQYITIY
.. || .  | .|..|.|..|. |  ..      |..||| | .||  .  || ..       .| | . .| |||.. .  |.|. ...  . 
llkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1496-1584 1.3e-07 25.4 In-house 196-279 (302) alignment 
Range on Protein: 1496-1584
Range on HMM: 196-279/302.0
IGWMNDGVLRDPRTVLQVIDDVIHRQQKigggpIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYIT
 .| . |  ... | |...      ...     ..||||  | |||   ||   .. |. . | |. .. . ... . ||| . .| | 
sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1311-1395 2.6e-07 24.4 In-house 34-118 (332) alignment 
Range on Protein: 1311-1395
Range on HMM: 34-118/332.0
NKPLNRFRNIVPYDDNIITLKlPGVAQHEYINASYIHGYSKARKFIAAQGPMK-KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKC
|  .||   .  .| . . |  |   . .. |||.. ||||   .| || |.. .|   || .. . ||. .... .. |  | |.
nmdmnriphlycfdhsrvela.pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1490-1593 8e-07 23.4 In-house 178-277 (307) alignment 
Range on Protein: 1490-1593
Range on HMM: 178-277/307.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVihrqqKIGGGPIVVHCSDTVSRTGVYCAISIALEQC-KAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
| ..|   | . || .   | . ... |     .    |.|||||  | |.|   |||.  ..  . .   |. .. . |.  .. |. |  ||. ..  
iqhlqwenwpdrgvpqinltainlleav.....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrv

LEMYL
|  |.
lleyf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1311-1475 1.1e-06 22.3 In-house 51-214 (302) alignment 
Range on Protein: 1311-1475
Range on HMM: 51-214/302.0
NKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYSKARKFIAAQGPMKKTL---VDFWCLIWQEKPASVVMLTNLVEDSKtKCEQYWPQCLNEIE
|   |.  ..  .|.|.. |.    .. .|.||| ..  .  |. | || | ...     .|| ...||| .|||.|    | .|   ....|.  .. .
nlkknqsedvpildsnlvkle...aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyk

QFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS
..| . |       . . . | .   | .|  .    . |.|| |... ||.  . |..  . |  ..
eygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1518-1589 2e-06 21.6 In-house 192-265 (281) alignment 
Range on Protein: 1518-1589
Range on HMM: 192-265/281.0
IHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRS-KPGAVTTLEQYITIYEAL
| |. .    | |.|||  | |.|   |. |||.  ..   . |. |.   |. . .  .| ||.||. |.. |
ilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1314-1463 3.4e-06 20.9 In-house 50-192 (303) alignment 
Range on Protein: 1314-1463
Range on HMM: 50-192/303.0
LNRFRNIVPYDDNIITLklpgvAQHEYINASYIHGYSkARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNeIEQFGPFS
 ||| ...  |   . |     ..  || |||..  |  .| | .| |. .|  ||| .| ..|   |..|    |  |   .  .|.  . . .|   |
knrfvdvicldhskvkl.....sdssyihasylelds.skkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.flkfeers

VTLLE---DYVMPDYVIRNISVTLQDGSGEVHAltqYHLTTWPDHGVPEYATP
. . |     ..  .|.. .||.  |    .|    .|  .||   .|  ..|
irvgefkrvelgdgwvlkvlsvsngdyksflhv...hhykawphnsipsdgsp
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1524-1587 4.7e-06 20.4 In-house 221-284 (310) alignment 
Range on Protein: 1524-1587
Range on HMM: 221-284/310.0
IGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
.  || |||||  . |..| .|. ..... .    ||. .|   |..|.   . |  ||. |  
vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1334-1456 4.8e-06 20.9 In-house 9-125 (130) alignment 
Range on Protein: 1334-1456
Range on HMM: 9-125/130.0
GVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTnLVEDSktkcEQYWPQClNEIEQFGPFSVTLLEDYVMPDYVIRNISVT
 . ...|||||..    ...... .| |. .| .||| .. .     .|.|   ||.     ..|||.  . .| .    .  | |    ...  .    
rlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg.sveee....deywpds.ePlewyeediivtltdrdefknikasnlei

LQDGSGEVHALTQYHLTTWPDHG
 .|     .||| .... ||  |
esdlneshqaltmfqisnwpsdg
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1497-1594 7.9e-06 19.5 In-house 190-286 (302) alignment 
Range on Protein: 1497-1594
Range on HMM: 190-286/302.0
GWMNDGVLRDPRTVLQVIDDViHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALEMYLA
 | .. |.    .. . . .| . ..  .  ..|.     . | |.  .  .|.|. ...  . . .. |...  .| || .|.||...| || .|. 
nWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1492-1591 8.2e-06 19.8 In-house 190-285 (305) alignment 
Range on Protein: 1492-1591
Range on HMM: 190-285/305.0
QFQVIGWMNDGVLRDPRTVLQVIDDVihrqqKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVD-VFQVTKALKRSKPGAVTTLEQYITIYEALE
..  | | . ||     ..|... .      .   ||||||||  . |||    .   |.|  |  ...   .. . ..  .  .. | .||. ... . 
hyhwidwpdrgvpaadlailelleka.....rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvil

M
 
n