Gene PTPRD-62 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP127_AA protein Get Run
AqueP127_AA_1270-1594 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1270-1486 1.3e-79 262.1 In-house 2-235 (301) alignment
Range on Protein: 1270-1486
Range on HMM: 2-235/301.0
LNDLGNHVACCHSDSnayFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLP---GVAQHEYINASYIHGYSKARKFIAAQGPMKKTL
|.|||.|||..||..   |.||.|.|..|.||.|.|||. .||.||||.||..|||| |.||      ..|.||||||||.|||...|||||||||||||
ledlgthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktl

VDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSG--------------EVHALTQYHLTTW
||||.|||||||.|.||.||| |..|.|||||||.. .| |.||||.||| ...|.||.|||...|..||||.              . . ..|...| |
vdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdW

PDHGV-PEYATPLMTLHKRVMSS--SAKGPILVHCSA
|..|| .|..| |. ... ..      .||..||||.
pqdGvvreprtvLqviddvihrqqkigggpvvVHCSd

subfamily_PTPRD_pd Subfamily PTPRD 1267-1487 6.4e-74 244.6 In-house 4-224 (564) alignment
Range on Protein: 1267-1487
Range on HMM: 4-224/564.0
PISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKT
||. ..| .|||  ...|.. |.|..|.. .|.  ....  . .||. ||. |||.|| . . | |..|. . .|||||.|.|| | ...||.|||...|
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaet

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClNeIEQFGPFSVTLLEDYVMPDYVIRNISVtLQDGSGEVHALTQYHLTTWPDHGVPEYATPLM
. ||| ..|... ...||||.|.| .|.||..|||.  .  |..| . ||| | . . ||.||....  .  | |..  .|.| | ||||||||.||.|.
iedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslL

TLHKRVMSS--SAKGPILVHCSAG
.| ..| ..  . .|||.||||||
dlirkvralnepdagPivVhCSaG

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1266-1487 7.2e-74 243.7 In-house 2-226 (305) alignment
Range on Protein: 1266-1487
Range on HMM: 2-226/305.0
LPISLNDLGNHVACCHSDSNAYFSEQFKDLYSGnDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKK
 .|.|.|| ...   ...|.  . .|.| ||.  .... || . .||  ||...|...||. | |.  . . ...||||||..||..  |.|.||||.|.
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPL
|..||| ||..||. ..||||.|||. | ||.||||.  .| ..||.|||.| .   ..||..|..... .|.. | ....||.||.|||||||..|| |
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

MTLHKRVMSSSAKG---PILVHCSAG
..| |||. .  |.   |.|||||||
lslikrvqkdqkkdkgvpllVhCsag

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1487-1601 3e-73 241.1 In-house 187-301 (301) alignment
Range on Protein: 1487-1601
Range on HMM: 187-301/301.0
GWNIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIY
.|...|.||. |..|||.|.||||||||||||||||||||||.||||||||||.||||..||.||||||||||||||||||..|||||||||||||..||
swdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiy

EALEMYLAINSTYSN
....|||..||||.|
dvidmylqlnstyan

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1268-1487 8e-67 220.1 In-house 2-226 (290) alignment
Range on Protein: 1268-1487
Range on HMM: 2-226/290.0
ISLNDLGNHVACCHSDSNAYFSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLK-LPGV--AQHEYINASYIHGYSKARKFIAAQGPMK
| ....|..||  |.  |  | .||| | ||. ...  |||   ||.||||.|||.|||| |||. ..|    ..|||||.||.||......||.|||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClnEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHG-VPEYAT
.|||||| |||||| . .||||| .|. |.|| ||||.   . ...|.||..||.. .. .|..|...|. .. .|. . .|||..|.|...| |....|
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

PLMTLHKRV--MSSSAKGPILVHCSAG
 |.......  .  . ...|.||||..
illvieemyktqrkrgntsivvHCSdt

0051299 (Phosphotyrosine protein) phosphatases II 1266-1488 3.3e-65 215.7 In-house 3-230 (288) alignment
Range on Protein: 1266-1488
Range on HMM: 3-230/288.0
LPISLNDLGNHVACCHSDSNAYFSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMK
 .||...| ..|   . ...... |.|..|.| . | ..|..|   |.. ||...|.|||.. . |.  .||  . |||||||.|| . |||||.|||..
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQD---GSGEVHALTQYHLTTWPDHGVPEY
.|. ||| ..|...   .||||.|||....||.||||.  .. ...|...||||. .|..||..|.. ||  |   |.||..  |..| |.|||||||..
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

ATPLMTLHKRVMSS--SAKGPILVHCSAGW
...|... ..|...  | .||..|||||| 
pellldflrlvrkalasgggpvvVHCsaGv

subfamily_PTPRB_pd Subfamily PTPRB 1264-1487 3.6e-63 208.3 In-house 3-228 (293) alignment
Range on Protein: 1264-1487
Range on HMM: 3-228/293.0
QTLPISLNDLGNHVACCHSDSNAYFSEQFKDLYS-GNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGP
.. ||.|... .||.  ..||.. |||....| . |.|.....  . .|.  ||..||.||| . . | .| . .. .||||.||.||.  |.|||.|||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

MKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIeQFGPFSVTLLEDYVMPDYVIRNISVTLqdgSGEVHALTQYHLTTWPDHGVPEYA
. .|. ||| ..|..|   .||||.|||  |.|||.|||.  ... ..|  .|||... .. |.|||.....    . | . ..||| |.|||||||| .
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPekt

TPLMTLHKRVMSS----SAKGPILVHCSAG
..|... ..| ..    ..|.||.||||||
ktlldfvrtvreaiektaskrPivvhCsaG

0050432 (Phosphotyrosine protein) phosphatases II 1268-1488 4.6e-63 208.7 In-house 26-243 (308) alignment
Range on Protein: 1268-1488
Range on HMM: 26-243/308.0
ISLNDLGNHVACchSDSNAYFSEQFKDLYSGND-KQCSVGLNGMNKPLNRFRNIVPYDDNIITLklpGvAQHEYINASYIHGY--SKARKFIAAQGPMKK
.|. || ...     ... ...|.|..|.|  .  ..||.|   ||..||...|.||| . . |   .   . ||||||..||   . |||||.|||...
lsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...d.egsdYInAsyvdgyssklprkfIatqgPlpn

TLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLN-EIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgEVHALTQYHLTTWPDHGVPEYATP
|. ||| ..|...   .||||.|||... ||.||||  |. .....|.|.||||. .|..||..|.. .|  ... |.. .|..| |.|||||||.....
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspei

LMTLHKRVMSSSAKGPILVHCSAGW
|... ..| .|  .|||.|||||| 
lldflelvrkslpggpivVHCsaGv

0040438 (Phosphotyrosine protein) phosphatases II 1272-1488 1.8e-62 206.8 In-house 4-220 (317) alignment
Range on Protein: 1272-1488
Range on HMM: 4-220/317.0
DLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFW
|| ...  ..  .. ...|.|.||.| .   .||..   ||..||...|.|||.. . |.  .|.  . ||||||..|... |||||.|||...|. |||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

CLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQdGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKR
 ..|...  ..||||.|.|... ||.||||.  .|  ..|.|.||||. ........|.. |.   |..|.. .|..| |.|||||||.. ..|  . ..
rmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldflea

VMSS--SAKGPILVHCSAGW
| ..  . .||.||||||| 
vrealedpggpvlVHCsaGv

0046845 (Phosphotyrosine protein) phosphatases II 1288-1488 4.5e-62 205.3 In-house 2-215 (284) alignment
Range on Protein: 1288-1488
Range on HMM: 2-215/284.0
FSEQFKDLYSGNDK---QCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGV--AQHEYINASYIHGY-----SKARKFIAAQGPMKKTLVDFWCLIWQEK
. |.|. |.| . |   ..||.|   |. .||...|.|||.. . || ..     ..||||||..||      . .||||.|||...|. ||| ..|...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

PASVVMLTNLVEDSKTKCEQYWPQClNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSS---
   .||||.|||....||.||||.  .|  ..|.|.||||. .|..||..|....|  . .||.. .|..| |.|||||||.....|... . | ..   
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-SAKGPILVHCSAGW
 . .|||.|||||| 
lpgggpivVHCsaGv

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1268-1487 1.5e-61 202.9 In-house 2-221 (287) alignment
Range on Protein: 1268-1487
Range on HMM: 2-221/287.0
ISLNDLGNHVACCHSDSNAYFSEQFKDLYS--GNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYSKARKFIAAQGPMKKT
|... .|. ||  |  .|  |..||. | .   ....  ...   ||..||...|...|.. . ||     ...||||..| ||.....||.|..|| .|
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfnt

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNeiEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHG-VPEYATPL
...||.||.....  .|||... |. . .| ||||.  .    .|.....||.. |. .|..|.. |. .. .|. . ..||..|.|...| |.|..| |
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil

MTLHKRVMS--SSAKGPILVHCSAG
. ..... .   .....|.||||..
lvieemyktqrkrgntsivvhCsdt

0045450 (Phosphotyrosine protein) phosphatases II 1262-1488 1.3e-60 201.0 In-house 3-245 (307) alignment
Range on Protein: 1262-1488
Range on HMM: 3-245/307.0
IPQTLPISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDK---QCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGV--AQHEYINASYI--------HG
.|  |.|.. .|  .|.  . |... . ..|..|.| ...    .|..|   ||..||...|.|||.. . |. ..     . ||||||.        .|
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

YSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYH
| . |||||.|||...|. ||| ..|...   .||||.|||. . || ||||.  .|  ..|.| ||||. .....|..|.. ||  ||.||.. .|..|
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfh

LTTWPDHGVPEYATPLMTLHKRVMS----SSAKGPILVHCSAGW
 |.|||||||..  .|  . ..|..    .. .||.||||||| 
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGv

0036941 (Phosphotyrosine protein) phosphatases II 1282-1488 1.3e-60 200.6 In-house 9-218 (297) alignment
Range on Protein: 1282-1488
Range on HMM: 9-218/297.0
SDSNAYFSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLklpGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPAS
....|.....|..|..   .  .||.|.  |...||...|.|||.. . |   .   . ||||||. ||.  |||||.|||...|. ||| ..|...  .
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

VVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYV--MPDYVIRNISVTLQdGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS---
.||||.|||. . ||.||||   .|  ..|.|.||||. .|   .||..|.. ||   |.||.. .|..| |.||||||||....|. . ..| .     
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

-AKGPILVHCSAGW
  .||.||||||| 
psggpvlVHCsaGv

0043336 (Phosphotyrosine protein) phosphatases II 1267-1488 4.1e-60 199.0 In-house 1-221 (278) alignment
Range on Protein: 1267-1488
Range on HMM: 1-221/278.0
PISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKT
||| .|| .... .. .... ....|..|.| .   .|..|   ||..||...|.||| . . |.| .|.  . ||||||. ||.. |||||.|||...|
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPqclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLqDGSGEVHALTQYHLTTWPDHGVPEYATPLM
. ||| ..|...  ..||||.|||....|| ||||   .. ...|.|.||||. ....||..|.. ||   |.||..  |.|| . ||||||||  ..|.
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslslll

TLHKRVMSS--SAKGPILVHCSAGW
 . |.|..   . .||.||||||| 
dflkavrealedsngpvlVHCsaGv

0039614 (Phosphotyrosine protein) phosphatases II 1258-1488 1.1e-59 197.7 In-house 4-233 (297) alignment
Range on Protein: 1258-1488
Range on HMM: 4-233/297.0
FDPKIPQTLPISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKqCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGV--AQHEYINASYIHGYSK-ARK
. ... .. ||.|. |  .. . . .|. .. ..|..|.| ..  .|..|   ||..||...|.|||.. . || ..     . ||||||. ||..  ||
lrdallesipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrk

FIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKtKCEQYWPQCLNeieQFGPFSVTLLEDYVMPDYVIRNISVTLqdgSGEVHALTQYHLTTWPD
|||.|||...|. ||| ..|...  ..||||.|||... ||.||||.  .   ..|.|.||||. .. ..|..|...||    .||.. .|... | |||
fIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpd

HGVPEYATPLMTLHKRVMSSS----AKGPILVHCSAGW
||||.... |. . . |..       .||.||||||| 
hgvppslellleflelvrealaelpkggpvlVHCsaGv

0047943 (Phosphotyrosine protein) phosphatases II 1282-1488 1.9e-59 196.7 In-house 8-216 (273) alignment
Range on Protein: 1282-1488
Range on HMM: 8-216/273.0
SDSNAYFSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLklpGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPAS
....... |.|..|.|   .  .||.|   || .||...|.|||.. . |   |   . ||||||. || . |||||.|||...|. ||| ..|...   
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

VVMLTNLVEDSKTKCEQYWPQCLNE-IEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMS----SS
.||||.|||... ||.||||.  .|  ...|.|.||||. .. .||..|.. .|  . . |..  |..| |.|||||||.. ..|... . |..    . 
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtg.esrtvthfhytgwpdhgvppslesllefielvrkalealp

AKGPILVHCSAGW
 .||..|||||| 
sngpvvVHCsaGv

subfamily_PTPRG_pd Subfamily PTPRG 1269-1487 1.7e-58 193.3 In-house 2-230 (563) alignment
Range on Protein: 1269-1487
Range on HMM: 2-230/563.0
SLNDLGNHVACCHSDSNAYFSEQFKDLYSGND---KQCSVGLNGMNKPLNRFRNIVPYDDNIITLK-LPGVAQ-HEYINASYIHGYSKARKFIAAQGPMK
 .... .||| .|.|..  |||.|..| |       ...   .  ||  ||  |||.||   ..|. |||. . ..||||.||.|| |...|||.|||.|
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTL---QDGS--GEVHALTQYHLTTWPDHGVP
.|. ||| .||... | .||.|||||. . ||..|||.  .| |..| ..||| |  |.  | .|....     ....   ...  .||| |.|||||||
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

EYATPLMTLHKRVMSSSAK--GPILVHCSAG
|...| ..  |.   .  .  |||.||||||
ehslpvLifvkkssaankaeaGPivvHcsaG

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1267-1487 2e-58 192.9 In-house 4-226 (319) alignment
Range on Protein: 1267-1487
Range on HMM: 4-226/319.0
PISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKT
.| ...| ...   .| .. .. ..||.|  ..... .   .  ||. ||..||..||   ..| .|.|| . .|||||.| || . .||||.|.|...|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLM
. ||| ..|.|.   |||||.|||  | |...|||.  ...|..| . |||.|.  . ||.||....  . .  |   ..... | ||||.|||.|| |.
iedfWrmvWeeessivvmltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

TLHKRVMSSSAK---GPILVHCSAG
 | ||.  |  |   ||| ||||||
dllkrirksrektqsgPivvhCsaG

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1270-1487 4.9e-58 191.5 In-house 6-222 (288) alignment
Range on Protein: 1270-1487
Range on HMM: 6-222/288.0
LNDLgNHVACCHSDSNAYFSEQFKDL-YSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLV
.... ..||  . .... |||... |   ...|. ..| .  |.. ||.|||.||| . . ||  . .|. .|||||||.|. | .|.||.|||. .|. 
ispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvn

DFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClNEIEQFGPFSVTLLEDYVMPDYVIRNISVTlqdGSGEVHALTQYHLTTWPDHGVPEYATPLMTL
||| |....|   .||||.|||. |||||.|||.  .. ...| . |||.|.  . |.| |.. .     ...   .|||. ..|||||||| ..||. |
dfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllel

HKRVMSSS--AKGPILVHCSAG
 . |  ..    |||.||||||
lrqvkvanqadtgpiivhCsaG

DSPc_SM00195 1288-1488 1.3e-56 187.2 In-house 2-206 (263) alignment
Range on Protein: 1288-1488
Range on HMM: 2-206/263.0
FSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPG-VAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLT
..|.|..| . . .|... .    ||  ||..||.|||.. . || .    ...||||.|| |..| .|.||.|||...|. ||| ..|.||   .||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMP-DYVIRNISVTLQDGsGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSA--KGPILV
. .|. |.||..|||.  .. |.|| .||.| |   .. ....|....| ..   | . .|||. ..|||||||. ..... | . | .|.   .|||.|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGW
||||| 
hCsaGv

PTPc_SM00194 1288-1488 1.3e-56 187.2 In-house 2-206 (263) alignment
Range on Protein: 1288-1488
Range on HMM: 2-206/263.0
FSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPG-VAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLT
..|.|..| . . .|... .    ||  ||..||.|||.. . || .    ...||||.|| |..| .|.||.|||...|. ||| ..|.||   .||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMP-DYVIRNISVTLQDGsGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSA--KGPILV
. .|. |.||..|||.  .. |.|| .||.| |   .. ....|....| ..   | . .|||. ..|||||||. ..... | . | .|.   .|||.|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGW
||||| 
hCsaGv

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1268-1487 3e-56 185.8 In-house 2-223 (318) alignment
Range on Protein: 1268-1487
Range on HMM: 2-223/318.0
ISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDK-QCSVGLNGMNKPLNRFRNIVPYDDNIITLK-LPGVAQHEYINASYIHGYSKARKFIAAQGPMKKT
||..|| .||.  ... . ..||... |   ...      |. .||  ||. ||..||.  . |. | |. . .||||.|| || . ...||||.|. .|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLqDGSGEVHALTQYHLTTWPDHGVPEYATPLM
. ||| ..|. . | .||||...| .|.|...|||.  .. ...|   |.| |.  . |||.|...||  ... |.    ||| |.|||.|||| .. |.
ieDfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgasll

TLHKRVMSSS---AKGPILVHCSAG
 | ..| .      .|||.||||||
dlvrqvskaqqksgagpivvhCsaG

subfamily_Ptp69D_pd Subfamily Ptp69D 1268-1487 1.4e-54 180.3 In-house 4-229 (307) alignment
Range on Protein: 1268-1487
Range on HMM: 4-229/307.0
ISLNDLGNHVACCHSDSNAYFSEQFKDLY-SGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKT
|.. || . .   . |..  . . .. |  .  ||...|. .  |.  ||. .|...|.. . | |..| .. .|||||.|.|| . .||||||.|.  |
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClnEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSG----EVHALTQYHLTTWPDHGVPEYA
. ||| .|.. .   .|||.|| | .. ||..|||.   .. |.|   |.| .   ..||.||...|. .. ..    . . ..||| |.|.|  ||| |
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TPLMTLHKRV--MSSSAKGPILVHCSAG
. |. | ..|  . .  ..||.||||||
rgllklieqvrelyklnrsPivvhCsaG

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1267-1487 4.7e-54 178.4 In-house 5-222 (315) alignment
Range on Protein: 1267-1487
Range on HMM: 5-222/315.0
PISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQH-EYINASYIHGYSKARKFIAAQGPMKKT
|| |..|  .||  .. ..  | .... .  |. .   |  . .||  ||. ||..||   . | |  . .| .|.||..| ||.| |..||||||   .
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvas

LVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClneIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDgsgEVHALTQYHLTTWPDHGVPEYATPLM
. ||| |...|. . .||||||||. | |.|.|||        .|...||. .. |  .| .| .||. .|   ... . |.|.|.||| |||.|..|||
vkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgd...nirevvqlhytswpdmgvpkytiplm

TLHKRVMSS--SAKGPILVHCSAG
 |...|.    .. |.|.||||||
nlirtvkqhhtnsvgaivvhcsaG

0045098 (Phosphotyrosine protein) phosphatases II 1289-1489 1.4e-53 177.4 In-house 11-218 (278) alignment
Range on Protein: 1289-1489
Range on HMM: 11-218/278.0
SEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITlklpgvaqhEYINASYIHGYsKaRKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLV
.| .  |  |.  .....|   |...||...|.||| . .          .|||||||.|| . .||||.|||...|. ||| ..|...  ..||||.||
lefefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy.p.kkfIatqgPlpstvadfwrmlwelgitvivmltelv

EDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQ---DGSGEVHALTQYHLTTWPDHGVPEYA--TPLMTLHKRVMSS---------
|... ||.||||   .. ...|.|.||||. .|..||..| . ||     . ..| . .|..|...|||||||..   ...  | ... .          
elgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

------SAKGPILVHCSAGWN
      . .||.|||||||..
sslllldsggpvlVHCsaGvg

Y_phosphatase Protein-tyrosine phosphatase 1311-1488 3.7e-53 175.7 Pfam-A 1-181 (235) alignment
Range on Protein: 1311-1488
Range on HMM: 1-181/235.0
NKPLNRFRNIVPYDDNIITLKLPGVAQHeYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFG
||  ||...|.|||.. . ||  . ..  ||||.|..||.. .||||.|||.|.|. ||| ..||||  ..||||.|.| ...||.||||.  .| ...|
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PFSVTLL-EDY-VMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS--AKGPILVHCSAGW
 ..|.|  .    . .|..|..... .... | . ..|.|.|.|||||||| ...|. | ..| .|.   .||..|||||| 
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGv

Y_phosphatase Protein-tyrosine phosphatase 1311-1488 3.7e-53 175.7 In-house 1-181 (235) alignment
Range on Protein: 1311-1488
Range on HMM: 1-181/235.0
NKPLNRFRNIVPYDDNIITLKLPGVAQHeYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFG
||  ||...|.|||.. . ||  . ..  ||||.|..||.. .||||.|||.|.|. ||| ..||||  ..||||.|.| ...||.||||.  .| ...|
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PFSVTLL-EDY-VMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS--AKGPILVHCSAGW
 ..|.|  .    . .|..|..... .... | . ..|.|.|.|||||||| ...|. | ..| .|.   .||..|||||| 
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGv

subfamily_PTPN6_pd Subfamily PTPN6 1286-1487 5e-53 175.1 In-house 26-237 (306) alignment
Range on Protein: 1286-1487
Range on HMM: 26-237/306.0
AYFSEQFKDLYSGNDKQ---CSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQHEYINASYIHGYS--KARKFIAAQGPMKKTLVDFWCLIWQEKPAS
| |.|.|..|   . |.    . |    ||  ||..||.|.|.. ..|| |.|....||||.||.. .  . ...||.|| ...|. ||| ..|||.   
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

VVMLTNLVEDSKTKCEQYWPQCLNEIEqFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTL----HKRVMSSS-
.||.|. || .| || .|||.  .. | .|  ||| ...  . ||..|..||. .. ..| . . ||| ..|||||||.    .. .    ...  ... 
ivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

-AKGPILVHCSAG
  .|||.||||||
aeagpivvhCsaG

0040439 (Phosphotyrosine protein) phosphatases II 1303-1488 7.7e-53 175.0 In-house 3-190 (249) alignment
Range on Protein: 1303-1488
Range on HMM: 3-190/249.0
CSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQ
.||.|   ||..||...|.||| . . |.  ||.  . |||||||.||   |.|||.|||...|. ||| ..|...  ..||||.|||  . ||.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

clNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQdGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS----AKGPILVHCSAGW
  ..  ..| |.||||. .|..||..|.. .|   . ||..  .... | |||||||..  .|. . ..|..       .||.||||||| 
..ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGv

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1281-1487 3.7e-52 172.4 In-house 22-233 (298) alignment
Range on Protein: 1281-1487
Range on HMM: 22-233/298.0
HSDSNAYFSEQFKDLYSGND----KQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQ
.. . . ....|. | |...    .. .|. .  ||  ||. .|...|   . |.   .  . .|||||..|.|..   |||.|.|...|..||| ....
kkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvte

EKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS
|. ...||||||.|  |||...|||.  .. |..| ..|.||..... |...|.. |. .. . . . . | | |.|||.||||.|| ...| ..|  | 
edigtiVmltnleeldktkyhkywPd..egketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasq

-AKG--PILVHCSAG
   |  |..|.||||
qqagnkpvivqCsaG

subfamily_PTPRA_pd Subfamily PTPRA 1266-1487 5.7e-52 171.6 In-house 12-238 (330) alignment
Range on Protein: 1266-1487
Range on HMM: 12-238/330.0
LPISLNDLGNHVACCHSDSNAYFSEQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMK
 |. ...| . .    .| |  | |.|. | .|. .  . .  .  ||  ||. ||.||| . . | .. || . .|||||.|.|| .  |||||||| .
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVT-LQDGS--GEVHALTQYHLTTWPDHGVPEY
.|. ||| .||. | |..||||.| |  ..||.||||.  . .  .|   |.. .. |. || .|.. |. | |..   ..  ..|.|.|.||| |||  
etvedfwrmiweqksativmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

ATPLMTLHKRVMSS--SAKGPILVHCSAG
.  .. | |.| .      ||| ||||||
piGmlkllkkvkklnqqsagpivvhcsaG

0042113 (Phosphotyrosine protein) phosphatases II 1304-1488 6.2e-52 171.8 In-house 2-187 (245) alignment
Range on Protein: 1304-1488
Range on HMM: 2-187/245.0
SVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQ-HEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQc
||.|   ||..||...|.|||.. . |. .|    . ||||||..||   .||||.|||...|. ||| ..|...  ..||||...|... ||.||||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

lNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLqDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMS---SSAKGPILVHCSAGW
 .|. ..| |.||||. ....||..|...||  .|..|..  ..|| . |||||||..   |  ....| .   ....||.||||||| 
.gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGv

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1282-1487 1.7e-51 169.9 In-house 14-219 (515) alignment
Range on Protein: 1282-1487
Range on HMM: 14-219/515.0
SDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPAS
.   . |||.|.||   |    .|  . .| . ||..||.||| . . |  .    ...|.|||||...   . .||.||| | .. ||| |..||... 
nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvtt

VVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGsgeVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK--G
..|.|.| |. | || .|||.   .  .|| ..| |.      . ..|.. |. .|    ....||.|.| |||.|||. .. |. | | | ..  .   
iamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyth

PILVHCSAG
|...|||||
pliihcsaG

subfamily_PTPN12_pd Subfamily PTPN12 1303-1487 1.7e-51 169.9 In-house 32-217 (290) alignment
Range on Protein: 1303-1487
Range on HMM: 32-217/290.0
CSVGLNGMNKPLNRFRNIVPYDDNIITLKLPG-VAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQ
 ..| .  |.  ||...|.||| . ..|.    . . .||||..|.| ..  ..||||||. ||| ||| .||. .   |||. ..||  |.|||.|||.
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

CLNEIEQFGPFSVTLLEDYVMP-DYVIRNISVTLQdgsGEVHALTQYHLTTWPDHGVPEYATPLMTLHKR--VMSSSAKGPILVHCSAG
  .|  .||.|.||| |.  .  |..|| . |. |   .| . ..|.| | |||||||. |..|. | .    . .| . |..||||||
egeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaG

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1283-1487 7.1e-51 167.9 In-house 16-220 (315) alignment
Range on Protein: 1283-1487
Range on HMM: 16-220/315.0
DSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASV
   | |||.|.||   .  .  |. . .| . ||..||.|.| . . |  .    ...|||||||... . . .||.||| | .. ||| ...|||....
rhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtti

VMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNIsVTLQdgSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSA--KGP
||.|.. |. | || ||||.   .  .|| ..|.||.     | |.|.. || .  | | . .||...| |||.||.. .. |. | | | ..    . .
vmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefs

ILVHCSAG
.|||||||
llvhcsaG

subfamily_PTPRK_pd Subfamily PTPRK 1269-1487 1.9e-50 166.5 In-house 5-220 (314) alignment
Range on Protein: 1269-1487
Range on HMM: 5-220/314.0
SLNDLGNHVACCHSDSNAYFSEQFKDLYSGndkqCSVGLNGMNKPLNRFRNIVPYDDNIITLK-LPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLV
  .|| ...|. .   .  | |... |. |      .  .  |.  ||. .|..||   ..|. . | .. .||||..| .| ....||..|||...|. 
rvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclnEIEQFGPFSVTLLEDYVMPDYVIRNISVTL-QDGSGEVHALTQYHLTTWPDHGVPEYATPLMT
||| |...|. ||.||||.||| .. || .|||.   . |..|.. |.|.|  .  ..|.|  .|.  . |  |.. . |.. ..||||.|| .|| |..
dfWrlvydencasivmltelvevgrvkClkyWPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllk

LHKRVMSSS--AKGPILVHCSAG
| .|| .|.   .|.|.||||||
lvrrvkksqeeeaGrivvhCsaG

0037934 (Phosphotyrosine protein) phosphatases II 1303-1488 4e-50 166.0 In-house 2-189 (243) alignment
Range on Protein: 1303-1488
Range on HMM: 2-189/243.0
CSVGLNGMNKPLNRFRNIVPYDDNIITLklPGvaqHEYINASYIHGYskaRKFIAAQGPMKKTLVD----FWCLIWQEKPASVVMLTNLVEDSKTKCEQY
.|..|  .|.. ||...|.|||.. . |  .|   . ||||..| ..   ...|| |||...|. |    || ..|...  ..||||.||| .. ||.||
fsiallpenlsknrysdilpydhsrvkl..eg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPqclNEIeQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVM----------SSSAKGPILVHCSAGW
||   .|. ..|.|.||||. ....||..|.....  | .....  ..|| . |||||||.  ..|. ... |             . .||.||||||| 
wp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv





subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1304-1487 2.4e-48 159.6 In-house 2-185 (250) alignment
Range on Protein: 1304-1487
Range on HMM: 2-185/250.0
SVGLNGMNKPLNRFRNIVPYDDNIITLKL-PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTkCEQYWPqc
||. .  ||  ||. .|...|   . |.   |  . .|||||..|||.. . |||.|||...|..||| ....|| ...||||||.|  || ..||||  
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..

LNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHaLTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK---GPILVHCSAG
 .. |..|   |.||.. .. ||..|.. .. .  ..|.. . |.| ..||| ||||.||  . | |.| .|  .   .|..|.||||
vekaekyGdvtvsllskeefadytkrklklskakkaderi.vrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaG

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1310-1487 3.5e-48 159.6 In-house 60-234 (319) alignment
Range on Protein: 1310-1487
Range on HMM: 60-234/319.0
MNKPLNRFRNIVPYDDNIITLK-LPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTnlvedsKTKCEQYWPQCLNEIEQ
 ||  ||. ||...| |.. |. | |.   .|||||.. || .  |.||||||.. || ||| .||. . ...|.||      | || ||||.  .. |.
qnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

FGPFSVTLLEDYVMpdYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMS----SSAKGPILVHCSAG
 .  .|...|.     ||.|.| .. .    ..  .||.|.  |||.|||.|...||.| |.|         . .|.||||||
rfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaG

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1310-1487 1.2e-47 157.8 In-house 24-198 (284) alignment
Range on Protein: 1310-1487
Range on HMM: 24-198/284.0
MNKPLNRFRNIVPYDDNIITLK-LPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTnlvedsKTKCEQYWPQCLNEIEQ
 ||  ||. .|...| |.. |. | |.   .|||||.| || .  |.||.|||.. || ||| .||. . ...|.||      | || ||||.  .. |.
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

FGPFSVTLLEDYVMpdYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMS----SSAKGPILVHCSAG
 .  .|...|.     ||.|.| .. .    ..  ..|.|.  |||.|||.|...||.| |.|         . .|.||||||
rfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsag

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1275-1487 4.4e-47 155.5 In-house 4-218 (281) alignment
Range on Protein: 1275-1487
Range on HMM: 4-218/281.0
NHVACCHSDSNAYFSEQFKDLYS-GNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCL
.|..  ....|| | |....|.. |.|.  .   .  |.  ||..||| ||   ... .     . .||||... ||.. ...||.|||. ..||.|| .
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIeQFGPFSVTLLEDYVMPDYVIRNISVtlQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRV-
.|..|   .||.|. .| .| || .|||.  .|. ..| . |. ..    . |. |....  .  |||   ..| . |.|||||||. .. |.  .| | 
vweqkvsaivmvtreieagklkChrYWPddnsel.kygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevl

--MSSSAKGPILVHCSAG
   ... | |...|||||
kltekktkaplvihCsaG

subfamily_PTPN3_pd Subfamily PTPN3 1290-1487 2.8e-46 152.7 In-house 19-218 (280) alignment
Range on Protein: 1290-1487
Range on HMM: 19-218/280.0
EQFKDLYSGN-DKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIH----GYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVML
 ||. ||  . . ..|.     | . ||.|.|.|||.  ..||    .. .||||.|.     . .   ..||.|||..||  ||| ..|..|   .|||
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk...esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TNLVEDSKTKCEQYWPQcLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDgSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSS--SAKGPILV
|.|||. ..|| ||||.  ..  ..| |||.. ..     ||.|.. .. .. . | . ..|   . |||||||. .. .... .|| .   ... |..|
ttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvv

HCSAG
|||||
hCsaG

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1311-1487 2.8e-45 149.4 In-house 3-182 (237) alignment
Range on Protein: 1311-1487
Range on HMM: 3-182/237.0
NKPLNRFRNIVPYDDNIITLKLPGVAqHEYINASYIHGYSK-ARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClNEIEQF
||  ||. ||| || . . || .| .  .||||.|..|.    .|.||||||.. .  ||| ..|||| . .|||| |.|  . || .|||.  .. . .
nkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaay

GPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK----GPILVHCSAG
| ..|.|  .  . || .| . .. .    ||  . ||..|.|||.|||.... |. . |...  | .    || ..|||||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsag

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1269-1487 1.8e-43 143.9 In-house 6-231 (325) alignment
Range on Protein: 1269-1487
Range on HMM: 6-231/325.0
SLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQH-EYINASYIHGYSKARKFIAAQGPMKKTLV
.. .| .||   ... .  |. .|. | | . .   |     ||  |||.|.|..| . . |.  . . . .||||||.. . |   |.||| |. .|. 
avvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

DFWCLI--WQekpASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTlQDGSGEVHALTQYHLTTWPDHGVPEYATPLM
|.| |.  |.   .|||...| ..  | .| .|||. . .  .||.. | |     . ||| | . |  |   ||  .. |..| .|.| ||... . |.
dlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvk.qvkkGetrsvkqfqlqswddmGvqkrpatli

T-------LHKRVMS-SSAKGPILVHCSAG
.       ...|| . . | .|||||||||
silqlvkavservtantkastpilvhcsaG

subfamily_PTPN23_pd Subfamily PTPN23 1284-1488 3.6e-43 142.4 In-house 13-223 (288) alignment
Range on Protein: 1284-1488
Range on HMM: 13-223/288.0
SNAYFSEQFKDLYSGND---KQCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYS-KARKFIAAQGPMKKTLVDFWCLIWQEKPA
 .. . ..||.| . .|   .. |. .  ..   ||.|.|.||| | ..|.     . .|||||.... |  . .|||.|.|...|| ||| .....|  
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkss

SVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMS------
 .|||..  |  |.|...|||.  .| ..||..|||| .   .. .| |..... .| . .|. ..  .||.||..|||.    |. . . | |      
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavq

SSAKGPILVHCSAGW
  .| |..|||||| 
rksktPlvvhCsaGv

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1284-1487 1.7e-42 140.2 In-house 7-209 (283) alignment
Range on Protein: 1284-1487
Range on HMM: 7-209/283.0
SNAYFSEQFKDLySGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVaqhEYINASYIH---GYSKARKFIAAQGPMKKTLVDFWCLIWQEKPAS
.|  | |..| | |  |... .  .  ||. ||...|||.| ... ||       .||||..|     | . .|.|.||.|...| |||| ....|| ..
nnklfrevlkrl.svpdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

VVMLTNLVEDSKTKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPL--MTLHKRVMSSSAKG
.||||.| || . || ||||.  .  |..|.| ||| ...    ..|... .  .  . .   |. | .  | . |       |  . . .     | ||
ivmltklqedlrikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkg

PILVHCSAG
||.||||.|
PivvhCstg

subfamily_PTPN13_pd Subfamily PTPN13 1291-1487 2e-41 137.1 In-house 16-212 (273) alignment
Range on Protein: 1291-1487
Range on HMM: 16-212/273.0
QFKDLYSG-NDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVaqheYINASYIHGYSK--ARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNL
.||.|      ..|.|| .  ||  ||.||..|||.  ..|.  |     |||||.|.        ..||.|||. .|  ||| ..|. |   ..|.|. 
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

VEDSKTKCEQYWPQCLNEIEQFGP-FSVTLLEDYVMPDYVIRNISVTlQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSA-KGPILVHCS
.|. | ||..|||.  |.  .    . |.||.   . ..|.|.. |. .  |||.. ... ....|||||||  |..|... ..| .    .|||.||||
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk.dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcs

AG
||
aG

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1303-1487 3.7e-41 136.0 In-house 21-211 (274) alignment
Range on Protein: 1303-1487
Range on HMM: 21-211/274.0
CSVGLNGMNKpLNRFRNIVPYDDNIITLKLPGVAQH--EYINASYIHGYSKARK-FIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYW
  . . | ..  ||...|.| .   ..|.   . ..  .|||| ||.||..  | ..|.|||. .|. ||| .|.||.   .||||.| |  ..||..|.
eeldvfgsqt.knryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyf

PQCLNE--IEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGsgeVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSS----SAK-GPILVHCSAG
|.  .    |..| ....  .     || .|....  .      . .. |  | |||| .|. |..|. | . | .|    .|| .|..||||||
Pdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1267-1487 6.2e-41 135.4 In-house 9-227 (297) alignment
Range on Protein: 1267-1487
Range on HMM: 9-227/297.0
PISLNDLGNHVAccHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVA-QHEYINASYIHGYSKarKFIAAQGPMKKT
|| | |.   |   .. .  .|||.|..| . | ..  |  . .| . .|..||.||| . ..|.  .   . .|.|||...|. .  ..|. | ||| |
piplsdfatlvq..knrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkat

LVDFWCLIWQEKPASVVMLTNLVEDSKtKCEQYWPQclNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDgSGEVHALTQYHLTTWPDHGVPE-----Y
. ||| ....|... .|||... |  | || .||..  . . .||  ||.||       .. |...|| .. .   . . ||. . |||. |..     .
vadfWamvldeqvstivmlnddnerdk.kcaryWsd..kgvttfGdvsvvllsvsereGfikrelevtkgk.akarrvvkqyqfveWPdkaverkdsass

ATPLMTLHKRVMSSSAKGPILVHCSAG
   |..  . . |. |.||.||||.||
llklisevrkdfsqnaegPllvhclaG

subfamily_PTPN9_pd Subfamily PTPN9 1310-1486 7.4e-41 135.1 In-house 41-232 (297) alignment
Range on Protein: 1310-1486
Range on HMM: 41-232/297.0
MNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQ
.|   ||. ... ||.  ..| |...  . .||||... || . . |||.|||.|||  ||| ..|...   .|| | .||  . || ||||.  .. ..
anleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessae

FGPFSVTLLEDYVMPDYVIRNISVTLQDgSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK---------------GPILVHCSA
|| .||. .|. .. ||..| . ..  .  .|   .| . ...|||.|||. |. |. . . | .  |.                ||.|||||
fgdlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

subfamily_PTPN1_pd Subfamily PTPN1 1299-1487 8.2e-41 134.6 In-house 20-211 (290) alignment
Range on Protein: 1299-1487
Range on HMM: 20-211/290.0
NDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLpgvAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQY
.| ....  .  |..|||.|.. |||   |.|.    |. .||||| ..     |..| .|||. .|   || ..|..|  .|||| ..|| ...|| ||
sdfptreaklpenrnlnryrdvspydhsrikler...adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPQCLN-EIEQFG--PFSVTLLEDYVMPDYVIRNISVTlQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSS----SAKGPILVHCSAG
|||  . .  ..    ..|.|..  .   |..| . .. .  . | . ....| ||||| ||||  . .. .  .| .|    | .|| ..|||||
wPqgeeekellledtklkvkliseerksyytvrllele.nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1310-1488 8.4e-41 134.7 In-house 7-185 (239) alignment
Range on Protein: 1310-1488
Range on HMM: 7-185/239.0
MNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKAR-KFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClneIE
.||  ||. ||| || . . | ||    . .||||||.. |  .   .||.|| .. .  ||| ..|||. . .|||| |.|  | || ||||.      
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...ts

QFGPFSVTLLEDYVMPDYVIRNIsVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAKG--PILVHCSAGW
..  . ||| .  |. ||.|| . |  | |  | . . |||.| |||.|||.||| .. |....   |  |  | ..||||| 
kycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagv

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1310-1488 1.1e-40 134.2 In-house 6-184 (239) alignment
Range on Protein: 1310-1488
Range on HMM: 6-184/239.0
MNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKAR-KFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQClneIE
.||  ||. ||| || . . | ||    . .||||||.. |  .   .||.|| .. .  ||| ..|||. . .|||| |.|  | || ||||.      
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...ts

QFGPFSVTLLEDYVMPDYVIRNIsVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAKG--PILVHCSAGW
..  . ||| .  |. ||.|| . |  | |  | . . |||.| |||.|||.||| .. |....   |  |  | ..||||| 
kycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagv

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1489-1596 5.9e-40 132.3 In-house 179-286 (305) alignment
Range on Protein: 1489-1596
Range on HMM: 179-286/305.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
...|.|.  | ..|| . . ..|..|..| ..|.|  | |..||||..|.||||..|..||||..|.|.|||||.|.|.|.......|.||.||  ...|
tvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhda

LEMYLAIN
|. ..   
ldelitcg

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1294-1487 1.1e-39 131.0 In-house 3-207 (270) alignment
Range on Protein: 1294-1487
Range on HMM: 3-207/270.0
DLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSK-ARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDS
.|  .. .. ..     .| |||...|.|     ..| .|    . .|||| |..|...  .|.|||.||.. || .|| .||.||  ..||.|.|.|. 
eldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkg

KTKCEQYWPQCLNE--IEQFGPFSVTLLEDYVMPDYVIRNISVTlqdGSGEVHALTQYHLTTWPDHGVPEYAT------PLMTLH---KRVMSSSAKG-P
..|||.|||.  .|    ..|  .|. |..  .  |..... ..    .|| . |. .. .||||||||. .        |...    .|. .. .|. |
rkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaeP

ILVHCSAG
.|||||||
llvHcsaG

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1297-1487 5e-39 128.8 In-house 38-220 (287) alignment
Range on Protein: 1297-1487
Range on HMM: 38-220/287.0
SgndkqcsvglngmnKPLNRFRNIVPYDDNIITLKLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCE
.                 ||. ...|.||. . |   |    .|||| |. .| .  .|||||||.  |. |||....... |||...|  ||... || 
a..............vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPQClNEIEQFGPFSVTLLE-DYVMPDYVIRNISVTLQDGSgEVHALTQYHLTTWPDHGVPEYATPLMTLHKRV-------MSSSAKGPILVHCSAG
.|||.  .   . | .||.||. |   |.| .| . .   ..  | . . |..| .|||....  |  |. .   |        ..|  ||..||...|
kywPer.evPmrvGGysvvlldydikePeygvralrlidletr.earvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1272-1487 3.2e-37 123.0 In-house 6-222 (439) alignment
Range on Protein: 1272-1487
Range on HMM: 6-222/439.0
DLGNHVACCHSDSNAYFSEQFKDLYSGNDK-QCSVGLN--GMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLV
.. .||   . . .  |.| |. . | . . .|   |     ... ||.......|   .|| ..||| .  |||| ||.|| . . .||.||| |.|  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWCLIWQEKPASVVMLTNLVEDSKtkceqYWPQCLNeiEQFGPFSVTLLEDYVMPDYVIRNISVTLQ-DGSGEVHALTQYHLTTWPDHGVPEYATPLMT
||| |....| . .||||||||  |     |||   .    .|  .|    .  .|.|||| . |  . | .   ... |.| ..|||. ||  |. .. 
dfwrlviekktvtivmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

LHKRVMSSS---AKGPILVHCSAG
. . . |.      ||..||||||
flrainsandkeeygpvvvhcsag

subfamily_CG42327_pd Subfamily CG42327 1311-1593 3.6e-36 119.4 In-house 28-315 (319) alignment
Range on Protein: 1311-1593
Range on HMM: 28-315/319.0
NKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKAR-KFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQ--CLNEI
 |. .|. |.||  .  ..| . .   . ||..|||. || .|.  .|||| .....  ||| ..|. .   .| ||.| |    .| .|.|    |.. 
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

EQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgEVHALTQYHLtTWPDHGVPEYATPLMTLHKRVMSS-----SAKGPILVHCSAGWNIVqFQVIGWMND
. .| . ||| .  |   |.|  . .   |.. |   || |    |.. .||   ..|...  .| ||       .   | . ||  .   ... |   .
slyGdilvtlkgrevkdryaistlllkrvdke.esrelthywy.kwleaevPaeeaaliamllevrsslksysleqanelreksatlets.mdadgskae

GVLRDPRTVLQVIDDVIHrqQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRSKPGAVTTLEQYITIYEALEMYL
      . .   |       ..   ||.|||||| | |||.  |  ||... .     ||. |.   ..| .  || | |||  ||  | .| 
agstssheingnissrsg..tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1490-1600 6.3e-35 115.4 In-house 180-290 (290) alignment
Range on Protein: 1490-1600
Range on HMM: 180-290/290.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..|.|.  | ..| . .| |.|.||  ... | | | ..|||||||||.|..|.||. .....|| |||.||||| | ..  ||| |.| .|| .|.. .
vtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv

EMYLAINSTYS
  ||   .|||
ltyldsfetys

subfamily_CG7180_pd Subfamily CG7180 1300-1487 1.8e-34 113.7 In-house 31-233 (296) alignment
Range on Protein: 1300-1487
Range on HMM: 31-233/296.0
DKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKtKCEQY
  .|  ||.  |.  ||  ..|||| | . | || | .. .||||.|. .. | ...|  ..|.|.|. .|| |...|.  .||.||.  . .| .. .|
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPQCLneIEQFGPFSVTLLEDYVMPDYVIRNISVTLQ---------DGSGEVHALTQYHLTTWPD-HGVPEYATPLMTLHKRVMSSS-------AKGPIL
||.     ||.|.. | ..|   ... .||.. .| .         . . |.  .....||.|.  . ||  .. |. | .|| .          .||..
wpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCSAG
|..| |
vvssdG

subfamily_PTPN14_pd Subfamily PTPN14 1299-1487 2.5e-34 113.6 In-house 37-239 (300) alignment
Range on Protein: 1299-1487
Range on HMM: 37-239/300.0
NDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQHEYINASYIHG--YSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCE
.| ..|.. .  |.. |||....||.|| . |.    ....||||| |.    .| |..|.||||...|. ||| ..|... . .||||.  || |.|. 
edallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

QYWPQC--LNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQdGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRV-------MSS----SAKGPILVH
.|.|..   ..  .|| | ||       . .. . . .     |.|   .     | ||||||||  .. .   ..|        |.    ..| |.|||
kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl.pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvh

CSAG
||||
CsaG

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1284-1487 2.8e-34 113.2 In-house 18-179 (392) alignment
Range on Protein: 1284-1487
Range on HMM: 18-179/392.0
SNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITL-KLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVV
 .| |.|.|.|| . .  . .|. . .|.. ||..||.||| . . |  .  .....|.|||||...   . .||.|||   .| ||| ...||......
hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttia

MLTNLVEDSktkceqywpqclneieqfgpfsvtlledyvmpdyvirnisvtlqdGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS--AKGPI
|.|.| |                                                  .... .|.|.| |||..||.... |. . | | .       |.
mvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpl

LVHCSAG
..|||||
iihcsag

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1314-1588 7e-34 112.0 In-house 36-290 (297) alignment
Range on Protein: 1314-1588
Range on HMM: 36-290/297.0
LNRFRNIVPYDDNIITLKlPGVAQHEYINASYIHGY--SKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGP
 ||.|.|. .||. . |.  ......|||| |.      .  |.| ||||...|. ||| |....    .||...| || . ||  |||.. .|  . | 
knryrdilatddtrvkll.rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagd

FSVTLLEDYVMPdYVIRN-ISVTLQDGsGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAKGPILVhcsagwNIVQ-FQVIgwmndgVlrdprt
. |  | ..    .       ..|     |   ..     .|||||||     |  .. .| |     |...       .|. | ..      |      
vvveflsstsde.fdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmml......alvemftam......v......

VLQVIDdviHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
.||.      | ..    ...||||  | |.||     . |.. . . . ||  . . |.  ..  | ||||.  .|.|
flqles...lraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda

subfamily_PTPRN_pd Subfamily PTPRN 1296-1487 1.1e-33 111.2 In-house 41-234 (297) alignment
Range on Protein: 1296-1487
Range on HMM: 41-234/297.0
YSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVA-QHEYINASYIHGY-SKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKT
|  ... ..|. .  |   || ....|||.....||    | ...||||| |     .|  .||.|||. .|. ||| ..|..  . .|.||.| |.. .
yeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvk

KCEQYWPQCLNEIeqFGPFSVTLLEDYVM-PDYVIRNISVTLQDgSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS--AKGPILVHCSAG
.|..|||.  .|.  .. . | |. ...   ||..| . .   . . |  ..||.|  .||..|||  | .|. . ..|  |      ||.||||.|
qckrywpdeGsev..yhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdG

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1489-1602 1.7e-33 110.8 In-house 174-287 (287) alignment
Range on Protein: 1489-1602
Range on HMM: 174-287/287.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
...|.|.  | . | . .|.|.| ||.. .. |.| | ..||||||||| |....||. .....|| |||.||||| |  .  |||.| | |||. |...
qvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindi

LEMYLAINSTYSNF
. .||   .|||.|
vleyldsfetysdf

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1315-1487 2.1e-33 110.2 In-house 60-226 (290) alignment
Range on Protein: 1315-1487
Range on HMM: 60-226/290.0
NRFRNIVPYDDNIITLKlpGVAQHEYINASYIHGYSKarKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSV
||....|  |   . ||     . .|. | |..|      || .||..|.| .|.| .. ||| | .||| .|.|| |.|||||.|.   |.  || ..|
nrykdvvcndktrvilk..dGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitv

TLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVmsSSAKGPILVHCSAG
.  |.    . .|...    .  ||  | |  ... .|||. |.  .  |. . . .    | ||. ||||||
lcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rkasGpvvvhcsaG

0051429 (Phosphotyrosine protein) phosphatases II 1339-1488 4.6e-33 110.4 In-house 5-161 (272) alignment
Range on Protein: 1339-1488
Range on HMM: 5-161/272.0
EYINASYIHGYSK---ARKFIAAQGPMKKTLVDFWCLiWQEKPASVVMLTNLVEDSKTKCEQYWP----------QCLNEIEQFGPFSVTLLEDYVMPDY
 ||||... || .    .......||.. |  ||| | ....  ..|.|....|  . ||..|||              .   .| ..||||. ....||
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYAtpLMTLHKRVMSssaKGPILVHCSAGW
..|.. .||. . ||.. ....| | |||||||. |  | .| . . .   .||.|||||||.
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGk

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1291-1487 9.7e-32 105.2 In-house 21-219 (307) alignment
Range on Protein: 1291-1487
Range on HMM: 21-219/307.0
QFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQhEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVED
.|. |   . .  .|     |   ||....   | . | .|..|.|  .|| | |.    | .|||.||||...|  .||... |||  ||.|| ...| 
efrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglas.dyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckviel

SKTKCEQYWPQCLNEIEQFGPF----SVTLL-EDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMssSAKGPILVHCS
.| |||||||    .   ||      ||. |  . . ||  . |..    | ...  .....  . |||.|||.     . | . |     . |..||||
akikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr..ydtnpvvvhcs

AG
||
aG

subfamily_ptpA1_pd Subfamily ptpA1 1269-1487 2.8e-31 103.7 In-house 9-239 (418) alignment
Range on Protein: 1269-1487
Range on HMM: 9-239/418.0
SLNDLGNHVACCHSdsnayFSEQFKDLY-SGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLK-LPGVAQHEYINASYIHGySKARKFIAAQGPMKKTL
|. .| ||. | |        |.|. |  |    . | | .  |   ||. ||.| .   . || .      .|||| || | .  ..||..|||. .|.
siynlknhikcihk.....ikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpnti

VDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCL---------NEIEQFGPFSVTLLEDYVMPDY--VIRNISVTLQdgsGEVHALTQYHLTTWPDH
 ||| ..|...   .|||.   |. . ||..|||. .         |  | || .|| |.|    |.   . ||| .|..   || . .|||.   ||||
adfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe...getrditqyqyegwpdh

GVPEYATPLMTLHK-------R-VMSSSAKGPILVHCSAG
 .|... |.  | .       . . ||  . ||.||||||
nipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

subfamily_PTPRD_pd Subfamily PTPRD 1490-1599 1.6e-30 101.3 In-house 179-287 (564) alignment
Range on Protein: 1490-1599
Range on HMM: 179-287/564.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQqKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. ||. . | . ||   ....|..|..| . . . . ||||||||  | |||....|.. ||. |.|..||..|. |||.. ..  | | |||| |.||.
VrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheai

EMYLAINSTY
  .||  .| 
lealacgnte

0041856 (Phosphotyrosine protein) phosphatases II 1311-1488 2.3e-30 100.9 In-house 1-120 (182) alignment
Range on Protein: 1311-1488
Range on HMM: 1-120/182.0
NKPLNRFRNIVPYDDNIitlklpgvaQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTnlvedsktkCEQYWPqclneieqfg
|...||...|.||| ..            ||||... |. .|..|||.|||...|. ||. ......  ..|.||         .|.|||          
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

pfsvtlledyvmpdyvirnisvtlqdgSGEVHALTQYHLTTWPDHGVPEyATPLMTLHKRVMSssAKGPILVHCSAGW
                           . . .. .||. . |||||||.    |  . ..| .   .||.||||||| 
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGv

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1489-1599 3.4e-30 100.3 In-house 186-296 (298) alignment
Range on Protein: 1489-1599
Range on HMM: 186-296/298.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
...|.... | . || .  ..||.....|   ||. |  |..|.||. | |.| ..||.  ||. |.| ||||||| |.|....||||.| |||. ||||
evrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyea

LEMYLAINSTY
   .|.  ...
vlealdsfnde

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1489-1598 3.4e-29 96.9 In-house 179-288 (319) alignment
Range on Protein: 1489-1598
Range on HMM: 179-288/319.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
....||   | ...| .. ...|... .. . ..|   ||||||||. | ||| .......||. | |||.|||.. . |.  ..  | . |||. ||||
evkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyea

LEMYLAINST
|  .. . .|
lleaveagdt

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1490-1600 1.1e-28 95.1 In-house 139-249 (250) alignment
Range on Protein: 1490-1600
Range on HMM: 139-249/250.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..|.. . | . || .  ..||.....|   ||..| .|..|.||  |.|.| ..||.  ||. | | |||||.| |.|.. .|.||..||||. .||..
vrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeii

EMYLAINSTYS
  .|   . |.
lkaldsvedya

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1301-1488 1.5e-28 94.2 In-house 27-211 (281) alignment
Range on Protein: 1301-1488
Range on HMM: 27-211/281.0
KQCSVGLNGMNKPLNRFRNIVPYDDNIITLKL--PGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQY
  |.|  . .|.  ||. ||   |   . ||.  |     .|| | ||.     | .| .||| |.|  ||| .||||. ...||| ...|  . || .|
dlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLqdgSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAkgPILVHCSAGW
.|.      ||  .||.  .  |    |   . ..     || . .|..    |||  ||| .  .. . ... . |.  | ..||||| 
fprnahcclqfdklsvsyedstvnkslvttrlnlsy...egetrlithwlwkewpdwqvpessevmlkilrkirarst..ppvihcsagv

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1314-1487 1.7e-28 94.3 In-house 51-229 (305) alignment
Range on Protein: 1314-1487
Range on HMM: 51-229/305.0
LNRFRNIVPYDDNIItlKLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGP--
 ||....   |.| .  || |   |||| | |.   .....|| .| |..||  ||| . .|.|  .. || ||.|    || .|..   ... .|    
knrykdvgcldnnrv..klegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekg

--FSVTLL----EDYV-MPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVmsSSAKGPILVHCSAG
   || .      ...   . ....  ....   ....  |.||   ||| |||   . .. | ..    ..|||| ||||||
qkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka..rpskgpivvhcsag

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1490-1600 2e-28 94.4 In-house 177-287 (318) alignment
Range on Protein: 1490-1600
Range on HMM: 177-287/318.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |...  | . ||. .. ..|... .| . ||| | ||||||||  | ||||..|..| ||. |||..|||||. | |.. ..  | | .||. ||..|
vrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvl

EMYLAINSTYS
  .||   |. 
lealasgdtev

0046845 (Phosphotyrosine protein) phosphatases II 1490-1601 3.2e-27 91.1 In-house 167-282 (284) alignment
Range on Protein: 1490-1601
Range on HMM: 167-282/284.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQK-IGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEG---VVDVFQVTKALKRSKPGAVTTLEQYITI
. .|....| ..||  .|. .|. ...| . ...  ||||||||||. |.|||...|. ..||| ..||   .|||... | |.. .||.|.|||||. .
vthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv

YEALEMYLAINSTYSN
|||| .||    |. .
yealleylklkltlle

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1302-1489 3.6e-27 90.1 In-house 26-215 (285) alignment
Range on Protein: 1302-1489
Range on HMM: 26-215/285.0
QCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYSKAR-KFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWP
.|.      |  |||. ..   ..  . ||     ...|| ||...   | .  .|..|||. .|| ||| .|.||| | |.||  |.|    ||  |.|
nctytayeanpdlnryadvrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp

QCLNEIEQFGPFSVTLLE--DYVMPDYVIRNISVT-LQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK-GPILVHCSAGWN
. | |. .|| . .|| |  .  .   .. ...|.  .| | |   . . ..  |||.  || | |.. |.| |     |  || ||||||  
eklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvg

0050432 (Phosphotyrosine protein) phosphatases II 1490-1599 7.8e-27 89.8 In-house 199-305 (308) alignment
Range on Protein: 1490-1599
Range on HMM: 199-305/308.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQqkiGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. .|. ..| ..||  .|. .|. .. | ...   .|||||||||. |.|||...|. ..||| ..|| ||||.. | |.. .||.|.|.|||. .|.||
vthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyral

EMYLAINSTY
 .||    |.
leylklkltk

0036941 (Phosphotyrosine protein) phosphatases II 1490-1598 1.3e-26 89.1 In-house 170-282 (297) alignment
Range on Protein: 1490-1598
Range on HMM: 170-282/297.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCK---AEGVVDVFQVTKALKRSKPGAVTTLEQYITI
. .|...||  .||  .|...|. |. | ...... .|||..||||. |.|.|...|. ..|.| .    || ||.... | |.. .||||.|||||. .
vthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

YEALEMYLAINST
|||| ..|  . |
yeallellkkklt

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1291-1491 1.4e-26 87.8 In-house 32-237 (310) alignment
Range on Protein: 1291-1491
Range on HMM: 32-237/310.0
QFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVED
|.. | . .|   .      .   ||. ..|  |.  . ||.     ..|| | |..       || .|||...|..||| .|.||.  |...| . .|.
qyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgee

SKTKCEQYWPqCLNEIEQFGPFSVTLLEDYvMPDYVIRNISVTLQDG---------SGEVHALTQYHLTTWPDHGVPEYATplMTLHKRVMSSSAKGPIL
 . ||  |||  |   | .|   || | .    .. | |..||.              .   ..  .   ||| |||.      |. .|...   .|| .
grpkcvgywp.slgvtetygcirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htvpqrllaqvrhgpcv

VHCSAGWNIV
|||||| . .
vhcsagkdrl

0051299 (Phosphotyrosine protein) phosphatases II 1490-1593 2.3e-26 88.4 In-house 184-286 (288) alignment
Range on Protein: 1490-1593
Range on HMM: 184-286/288.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. .|....| ..||  .|. .|. . .|.. ..  ||||.|||||. |.|||...|. ..||| ..||.|||... | |.. .||.|.|.|||. .||||
vthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal

EMYL
 .||
leyl

0036282 (Phosphotyrosine protein) phosphatases II 1339-1489 2.6e-26 87.8 In-house 3-116 (174) alignment
Range on Protein: 1339-1489
Range on HMM: 3-116/174.0
EYINASYIHGYSKARKFIAAQGPMKktlvdFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclneieqfgpfsvtlledyvmpdyvirnisvtlqDGS
 |||||.....   ...|| |||..     || ......  .||||....|. ..|| .|||                                   . .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lre

GEVHALTQYHLTTWPDHGVPEYATpLMTLHKRVMSS---SAKGPILVHCSAGWN
 ...   ||. . |||||||. .. | .. |.| .    . .||.||||||| .
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvg

0047943 (Phosphotyrosine protein) phosphatases II 1490-1593 1.7e-25 85.5 In-house 168-272 (273) alignment
Range on Protein: 1490-1593
Range on HMM: 168-272/273.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. .|.. || ..||  ..  .|. |..| . .... ..||.|||||. |.|||...|. ..|.| ..|| |||... | |.. .||.|.|.|||. .|||
vthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyea

LEMYL
| .||
lleyl

0039614 (Phosphotyrosine protein) phosphatases II 1490-1596 2.1e-25 85.2 In-house 185-292 (297) alignment
Range on Protein: 1490-1596
Range on HMM: 185-292/297.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. .||..||  .||  .....|.... | .....  .|||..||||. |.|||...|. ..|||.. || |||... | |.. .||||.|..||. .|.|
vthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda

LEMYLAIN
| ..|  .
llellkrk

0040438 (Phosphotyrosine protein) phosphatases II 1490-1599 3.4e-25 84.4 In-house 174-282 (317) alignment
Range on Protein: 1490-1599
Range on HMM: 174-282/317.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkiG-GGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. .|. .||  .||  .|...|. .. | . ..  . |||..||||. |.|||...|. ..|||.. || |||... | |.. .||||.|.|||. .|.|
vthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda

LEMYLAINSTY
| .||  . |.
lleylkrkltl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1297-1487 3.9e-25 83.4 In-house 19-202 (267) alignment
Range on Protein: 1297-1487
Range on HMM: 19-202/267.0
SGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDsktKCE
| .  ..|  .   |.  ||. . .||||... |.     ..|||||||..|| . ..||. |.|.|.|  ||. .| ..| . .|.||.  .|   .  
sdtsstisqsiaeknqernrlddnlpyddtrvilr...tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nir

QYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDGSgeVHALTQYHLTTWPDH-GVPEYATPLMTLHKRVMSSSAKGPILVHCSAG
..||  . . ...  ..|    .    || |  . . ... |   | .| |.   |        |  ||. .  .     .  |..|.||.|
lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknes..ahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdG

DSPc_SM00195 1490-1593 5.2e-25 83.6 In-house 160-262 (263) alignment
Range on Protein: 1490-1593
Range on HMM: 160-262/263.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |.|. .| . ||  ... ||...  | ......  ||||||||. |.|||....|.|.|.....|  ||.|.. |.|. ..||.|.|||||..||||.
vtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeai

EMYL
  |.
leyi

PTPc_SM00194 1490-1593 5.2e-25 83.6 In-house 160-262 (263) alignment
Range on Protein: 1490-1593
Range on HMM: 160-262/263.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |.|. .| . ||  ... ||...  | ......  ||||||||. |.|||....|.|.|.....|  ||.|.. |.|. ..||.|.|||||..||||.
vtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeai

EMYL
  |.
leyi

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1341-1507 6.8e-25 82.4 In-house 78-245 (301) alignment
Range on Protein: 1341-1507
Range on HMM: 78-245/301.0
INASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLE-DYVMPDYVIrNISVTLQDGSG
| | .|    ....|||.|||.|.|  ||| .. | .   .|||.. ||. ..|||.| |.  .|  . | |.... . .... . .. . .. ..| .|
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkis.krtlevedstg

EV--HALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSsaKGPILVHCSAGWN-IVQFQVIGWMNDGVLRDP
..  ...| |  ..|.|.|||.  . |. | . |  |  . ||.||||||    | |    ..   |. ||
kfatrtvthyqysewtdrgvPkshaelfdlmelvkks..ekPivvhcsaGiGrsvafigteylareveadp

subfamily_PTPRA_pd Subfamily PTPRA 1490-1593 7.8e-25 82.4 In-house 193-295 (330) alignment
Range on Protein: 1490-1593
Range on HMM: 193-295/330.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGgPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. ||   .| . ||  .|. .|...  | . .|. .| |||||||  | ||| .....  ||. |||..||||.. | |.  .|  | |.|||  ||..|
vrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvl

EMYL
  | 
leyy

0043336 (Phosphotyrosine protein) phosphatases II 1490-1592 1.2e-24 82.7 In-house 175-276 (278) alignment
Range on Protein: 1490-1592
Range on HMM: 175-276/278.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..... .||. .||  .. ..|. . .|.....   .||..||||. |.|||...|. ..||| . || ||.... | |.. .||||.|..||. .||||
vthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

EMY
 .|
ley

0045450 (Phosphotyrosine protein) phosphatases II 1490-1593 1.3e-24 83.0 In-house 197-304 (307) alignment
Range on Protein: 1490-1593
Range on HMM: 197-304/307.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPGAVTTLEQYITI
. .|. .|| ..||  .. ..|. |. | . ...  .|||..||||. |.|||...|. ..|.| ..||.   ||.... | |.. .||||...|||. .
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

YEALEMYL
|||| ..|
yeallell

0043147 (Phosphotyrosine protein) phosphatases II 1338-1489 1.9e-24 81.8 In-house 5-112 (172) alignment
Range on Protein: 1338-1489
Range on HMM: 5-112/172.0
HEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLvedsktkceqywpqclneieqfgpfsvtlledyvmpdyvirnisvtLQDG
. ||||||...| . ..||| |||.  || ||| ......   .|.||.|                                              | |.
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydp

SGEVHALTQYHLTTWPDHGVPeYATPLMTLHKRVMS---SSAKGPILVHCSAGWN
.....   ||. . |||||||  .  |. . . . .    | .||.|||||||..
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvg

Y_phosphatase Protein-tyrosine phosphatase 1491-1589 3.2e-24 81.0 Pfam-A 136-233 (235) alignment
Range on Protein: 1491-1589
Range on HMM: 136-233/235.0
VQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQqKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
 |... .| . || ..|. .|..|..| ... .   ||.|||||. |.|||...|..|.|||..||. |||.|. | |....||.|..||||| .|.|.
kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 1491-1589 3.2e-24 81.0 In-house 136-233 (235) alignment
Range on Protein: 1491-1589
Range on HMM: 136-233/235.0
VQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQqKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
 |... .| . || ..|. .|..|..| ... .   ||.|||||. |.|||...|..|.|||..||. |||.|. | |....||.|..||||| .|.|.
kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai

0040439 (Phosphotyrosine protein) phosphatases II 1490-1593 4.3e-24 80.9 In-house 142-246 (249) alignment
Range on Protein: 1490-1593
Range on HMM: 142-246/249.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. ..|...|  .||  .. ..|. |. | . ....  |||..||||. |.|||...|. ..||| . |. ||.... | |.. .||||...|||. .|||
vlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea

LEMYL
| ..|
llell

subfamily_PTPRK_pd Subfamily PTPRK 1490-1593 4.4e-24 79.9 In-house 175-278 (314) alignment
Range on Protein: 1490-1593
Range on HMM: 175-278/314.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKiGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA-
. ||| .|| . .|    ...|...  | . |.. . |.||||||    |||...||.| |.  . |||||||.. |.|. .|.  | | |||. ||.. 
vrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

LEMYL
||  |
leacl

0046846 (Phosphotyrosine protein) phosphatases II 1339-1488 4.7e-24 80.5 In-house 13-120 (176) alignment
Range on Protein: 1339-1488
Range on HMM: 13-120/176.0
EYINASYIHGYskarKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQclneI----Eqfgpfsvtlledyvmpdyvirnisvtl
 ||||..| |.    ..|| |||. .|| ||. ......   ||.||..|| .. || .|||.    .                                
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi...........................

qdgsgevhaltQYHLTTWPDHGVPEYaTPLMTLHKRVMSSSAKG-PILVHCSAGW
           ||. . |||||||.. . |..| . . .   .| |.||||||| 
...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGi

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1311-1488 5.1e-24 79.4 In-house 55-232 (305) alignment
Range on Protein: 1311-1488
Range on HMM: 55-232/305.0
NKPLNRFRNIVPYDDNIITLKLPGvaQHEYINASYIHGY-SKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQF
..  ||....   | ... |. |     .|| | |.       ..||.||||. .|. .|| .. |.|   .||| . ||  | || |||| .  |  ..
aitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

GPFSVTLLEDYVMP---DYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVmsSSAKGPILVHCSAGW
    |        |   |  |.   . |    ..  .. . . | ||| |||      . |   .    .| ||.|||||| 
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai..rgskvpivvhcsagi

0049260 (Phosphotyrosine protein) phosphatases II 1345-1489 5.9e-24 79.9 In-house 1-101 (152) alignment
Range on Protein: 1345-1489
Range on HMM: 1-101/152.0
YIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWpqclneieqfgpfsvtlledyvmpdyvirnisvtlqdgsgevhal
.|.|| . ..|||.|||.  || ||| .... .   .||||.|.|. | |||||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

tQYHLTTWPDHGVPEYATPLMTLHKRVMS--SSAKGPILVHCSAGWN
 ||. . |||||||. .  |. |.. .     . .||.||||||| .
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvg

PTPc_DSPc_SM00012 1490-1589 9.2e-24 79.0 In-house 2-103 (105) alignment
Range on Protein: 1490-1589
Range on HMM: 2-103/105.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIG-GGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRSKPGAVTTLEQYITIYE
. .... || . || ...  .|.....| . ..|.. ..|.|||||. |.|||...|..|.|.|...| . ||.||. |.|....||.|.|.|||. .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AL
||
al

0049772 (Phosphotyrosine protein) phosphatases II 1305-1489 1.1e-23 79.9 In-house 40-224 (314) alignment
Range on Protein: 1305-1489
Range on HMM: 40-224/314.0
VGLNGMNKPLNRFRNIVPYDdNIITLKLPGVAQHEYINASYIHGYskaRKFIAAQGPMKKTLVDF----------WCLI--WQEKPASVVM---------
|.   .|.  ||. .|.|.| |   |.  .|  . ||||||..|.   .||||.|||.. |.|||          | ..  .. ..  .||         
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTNLVEDSktkceQ-YWPQCLNEIEqfgpfsvtllE-----DYVmpdyvirnisvtlqdgsgeVHALTQYHLTTWPDHGVPeYATPLM
            |..| .         .... | ...          |     ...                    ..  .|. . .||...|     . 
lsrLdaAlgKtpllildgng.....neptaadlellk..........eelydpelf...................erlgikylripvpDgsap.lledfd

TLHKRVMSSSAKGPILVHCSAGWN
 . . . . ...||.||||.||..
eflefieeadkggpvlvHCkaGkg

0042113 (Phosphotyrosine protein) phosphatases II 1490-1593 3.3e-23 77.8 In-house 140-243 (245) alignment
Range on Protein: 1490-1593
Range on HMM: 140-243/245.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..... ..|  .||  .....|.... | . ... ..||..||||. |.|||...|. ..||| ..|. |..... | |.. .||||.|..||. .||||
vihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal

EMYL
 ..|
lell

subfamily_Ptp69D_pd Subfamily Ptp69D 1489-1595 3.6e-23 77.1 In-house 183-288 (307) alignment
Range on Protein: 1489-1595
Range on HMM: 183-288/307.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
..||..  || .  | . .|..|..|. | . ...   .|||||||  |.|.|.. |... |.|.|||  ||.|...| |.. ..  |. ||||. .| |
kvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyra

LEMYLAI
|  |   
lldyssy

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1314-1487 4.9e-23 76.6 In-house 46-214 (288) alignment
Range on Protein: 1314-1487
Range on HMM: 46-214/288.0
LNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFS
 .|..|.   |   . |.      . ||.|  .      |..| || |.. |.  .| .. ..    .|||..|.|  | | ..|.|  | |  ..| . 
rdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlc

VTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVmsSSAKGPILVHCSAG
    ....  | ...   .  .    |   . . ||  |.|.||||   . . | ...   | . ||.||.|||
tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqkPivvhssaG

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1490-1591 2e-21 71.2 In-house 164-265 (283) alignment
Range on Protein: 1490-1591
Range on HMM: 164-265/283.0
IVQFQVIGWMNDGVlRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
.  .|||.|.. |    .   |  .. ||  |..   |||||||| .. ||.|..|.| .... ..| |||||.| | ..  ...|| ||.||  ..|. 
lahyqvidWleyge.qaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

-EM
 | 
leq

0045098 (Phosphotyrosine protein) phosphatases II 1489-1594 4.7e-21 70.8 In-house 155-273 (278) alignment
Range on Protein: 1489-1594
Range on HMM: 155-273/278.0
NIVQFQVIGWMNDGVLRDP--RTVLQVIDDVIHRQQK------------IGGGPIVVHCSDTVSRTGVYCAISIALEQCkaEGVVDVFQVTKALKRSKPG
.. ... ..|   ||  .|  . .|.... . .....             .|||..||||  |.|||...|. . ||..  ||.||.... | |.. .||
gvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpg

-AVTTLEQYITIYEALEMYLA
 ||..||||. .||.| ..| 
lavqnleqyrflyefllelll

subfamily_PTPN6_pd Subfamily PTPN6 1489-1599 5.4e-21 69.9 In-house 187-303 (306) alignment
Range on Protein: 1489-1599
Range on HMM: 187-303/306.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIG---GGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPGAVTTLEQY
...|..   | . || .|| .||. ..|| ..|...     ||||||||. . ||| .  | | |.. . .|.   .|. .. | ... . | | | .||
evfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqy

ITIYEALEMYLAINSTY
  .|.|...|.  ....
kfvykaikkyietkkkl

0037934 (Phosphotyrosine protein) phosphatases II 1490-1592 1.9e-20 68.9 In-house 135-241 (243) alignment
Range on Protein: 1490-1592
Range on HMM: 135-241/243.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQK-------IGGGPIVVHCSDTVSRTGVYCAISIALEQCkaeGvVDVFQVTKALKRSKPG-AVTTLEQ
..... ..|   ||  .|  .|. .|.|.  ...        .|||..||||  |.|||...|. . |...   | ||.... | |.. .|| ||.|..|
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsq

YITIYEALEMY
|. .|||| ..
yrflyeallel

subfamily_CG7180_pd Subfamily CG7180 1491-1597 2e-20 67.6 In-house 183-294 (296) alignment
Range on Protein: 1491-1597
Range on HMM: 183-294/296.0
VQFQVIGWMN-DGVLRDPRTVLQVIDDVIHRQQKI----GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITI
 .||.  |   | |     ......  |   ..|.      ||.||..|| .||.|||.|| ..||. . |. ||||.  | |.||.|. | . |.|  |
klfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyi

YEALEMYLAINS
|. |. ..  | 
Ydvlleavlcnk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1490-1595 2.4e-20 67.9 In-house 180-291 (325) alignment
Range on Protein: 1490-1595
Range on HMM: 180-291/325.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-----GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYIT
. |||. .| . || . | |.. ... | . ....     . .||.||||. | ||||. ..  ||..   |  ||.|.. | |.. .|  | | .||| 
vkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyil

IYEALEMYL-AI
|||||  .. . 
iyealveaymsg

subfamily_PTPRG_pd Subfamily PTPRG 1490-1594 5.4e-20 66.1 In-house 185-288 (563) alignment
Range on Protein: 1490-1594
Range on HMM: 185-288/563.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDViHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |..   | . ||   .  ||. .     . .|   ||||||||  |.|||.|....  |.| ..| .|.||.. | ..  ..  |.| |||| ...||
vrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal

EMYLA
   .|
leaia

subfamily_egg_pd Subfamily egg 1321-1487 5.7e-20 66.2 In-house 50-211 (307) alignment
Range on Protein: 1321-1487
Range on HMM: 50-211/307.0
VPYDDNIITLKLP-GVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDskTKCEQYWPQCLNEIEQF--GPFSVTLL
   |   ..|.|. |    ..| | ...|     .|| || |.| |  ||| ...||.   .||||  .|    .|| |||.. ..  ..  | . .. |
hckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienl

EDYVMPDYVIRNISVTLQDGSGEVHALTQYHlttWPDHGVPEYATPLMTLHKRVmssSAKGPILVHCSAG
. .  .| . |   . |  |  |   |  .    .  . . .  .||  | |      .  |..|..  |
kvdskadplfrvtklklvGgddeerflehwq...gdvnnssdvysplrvlrklr...nlskpvvvqdilG

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1489-1593 1.5e-19 65.1 In-house 176-280 (315) alignment
Range on Protein: 1489-1593
Range on HMM: 176-280/315.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGgGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
..||...  | . || .   .....|  |   ...   |.||||||. | ||| .....  |.| .|| ..||... . ... . ..| ..|||  ||.|
evvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda

L-EMYL
| | ..
lletfv

0044763 (Phosphotyrosine protein) phosphatases II 1331-1489 2.7e-19 65.0 In-house 11-122 (178) alignment
Range on Protein: 1331-1489
Range on HMM: 11-122/178.0
KLPGVAQHEYINASYIHGYskarKFIAAQGPmkktlVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNeieqfgpfsvtlledyvmpdyvirni
.|.|.   .|||||.| ..     ......|     .|.. |.....  ..|.||. .|  . || .|||.  .                          
nleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..........................

svtlqdgsgevhalTQYHLTTWPDHGVPEYATPLMTLHKRVMSS--SAKGPILVHCSAGWN
               ||. . .||||||.    .. ... . .   . .||.|||||||..
..............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1489-1589 4.1e-19 64.0 In-house 186-287 (319) alignment
Range on Protein: 1489-1589
Range on HMM: 186-287/319.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGG-GPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
.| ||   || . ||   |  ...... | | ..|  .  .||||||  | ||||| .. . |.. | |  |||... . |.. ..  |  | ||  || 
kitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

AL
||
al

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1489-1590 4.3e-19 63.6 In-house 176-276 (288) alignment
Range on Protein: 1489-1590
Range on HMM: 176-276/288.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
.| |.|  .| ..|| .. . .|.... |   .|.   |||.||||. | |||.. |.  .... ..| ..||. . . |.....  | ||.||. |||.
eitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyev

LE
| 
ll

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1491-1598 5.4e-19 63.4 In-house 180-289 (297) alignment
Range on Protein: 1491-1598
Range on HMM: 180-289/297.0
VQFQVIGWMNDGVLR--DPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
 |.| . | .. | |  . ...|..|..| .  ..   ||..|||.  | ||||...|   . . | |  ||.|.. | |....|  | | |||  .|.|
kqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyva

LEMYLAINST
.  .|  . |
vleallsedt

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1490-1597 6e-19 63.0 In-house 175-281 (315) alignment
Range on Protein: 1490-1597
Range on HMM: 175-281/315.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRqQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |||  .| . || ..  ..|..| .|    ..    ...||||  | |||| ..|   ..| | . .||||.. | |.. .|  | | |.|  ||.|.
vtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydav

EMYLAINS
  .|    
ledllwrn

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1497-1593 6.4e-19 63.1 In-house 170-268 (274) alignment
Range on Protein: 1497-1593
Range on HMM: 170-268/274.0
GWMNDGVLRDPRTVLQVIDDVIHRQQKI--GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALEMYL
 | .  . .|..|.|.....| . ...     .|.|||||  . |||.. |||||. | ..|.||||....  |.  . | | | |||  |..|| .||
dWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1490-1596 6.7e-19 62.4 In-house 174-279 (515) alignment
Range on Protein: 1490-1596
Range on HMM: 174-279/515.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGgGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. ||.  .| . || .. ...|..| .|   ....   |...|||  | ||||...|   . . |   .||||.. . ... .|  | | |||  ||.|.
vtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav

EMYLAIN
  .|   
ledllwr

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1489-1589 6.8e-19 63.4 In-house 150-251 (284) alignment
Range on Protein: 1489-1589
Range on HMM: 150-251/284.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGG-GPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
.| ||   || . ||   |  ...... | | ..|  .  .||||||  | ||||| .. . |.. | |  |||... . |.. ..  |  | ||  || 
kirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

AL
||
al

0051082 (Phosphotyrosine protein) phosphatases II 1339-1489 1.3e-18 62.5 In-house 4-104 (151) alignment
Range on Protein: 1339-1489
Range on HMM: 4-104/151.0
EYINASYIHGYskarkFIAAQGPMKktlvDFWCLIWQEKPASVVMLTNLVEDSktKCEQYWPQCLneieqfgpfsvtlledyvmpdyvirnisvtlqdgs
 |||.||. |.     ... .||.     ||. |.....  ..|.|....|    .| .|.|.                                     
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

gevHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSsSAKGPILVHCSAGWN
   . ....... |||.|.|..   .. ... ...   .||.|||||||..
...ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkg

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1297-1401 1.7e-18 61.5 In-house 35-152 (350) alignment
Range on Protein: 1297-1401
Range on HMM: 35-152/350.0
SGNDKQCSVGLNGMNKplNRFRNIVPYDDNIITLK----L-----PGVAQHEYINASYIHGY----SKARKF--IAAQGPMKKTLVDFWCLIWQEKPASV
  || . | |.. . |  ||..||.||. . . ||            .   .||||.|..      .   .|  ||.|.|...|. ||. .| . |   .
psnDvilseGvelfak..nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvi

VMLTNLVEDSKTKCEQYWPQ
..||..||    ||..||..
lsltsdvelnlekcyrYWqe

subfamily_PTPRB_pd Subfamily PTPRB 1490-1593 2.7e-18 61.1 In-house 181-285 (293) alignment
Range on Protein: 1490-1593
Range on HMM: 181-285/293.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQ-QKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. |.. . | . ||  ...|.|. .  | ... ..   .|||||||  | |||.. |.   |.. . | .||.| .  .|....   | | .||| |...
vrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqc

LEMYL
.  .|
vldll

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1301-1489 3.8e-18 60.2 In-house 35-221 (312) alignment
Range on Protein: 1301-1489
Range on HMM: 35-221/312.0
KQCSVGLNgmNKPLNRFRNIVPYDDNIITLKlpGvAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWP
 .|.  |.   | |||. ||  .|   .||   |  .  || | ...  .|  .|...|||...| . || |      .|...|. .|||.  || .|  
sectaflk..fkdlnrypniqcwdrgrftla..g.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyis

QCL--NEIEQFGPFSVTLLEDY---VMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMssSAKGPILVHCSAGWN
. .   ..|.   ..    |        | .   .   .   .|.   | .|  ..|||||.|.     . |   |     | |.. |||||  
divgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk..kdkkpviahcsagvg

subfamily_PTPN12_pd Subfamily PTPN12 1489-1592 1.4e-17 58.5 In-house 171-276 (290) alignment
Range on Protein: 1489-1592
Range on HMM: 171-276/290.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPGAVTTLEQYITI
.. ||.   | . || . . ..|..|..| ..|.     |.|||||  | |||. .|| .. |. ||| .   .|||..   |.. .. .| | |||  .
kvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelv

YEALEMY
|.|.. .
ykavael

0036282 (Phosphotyrosine protein) phosphatases II 1490-1587 2.1e-17 58.8 In-house 69-164 (174) alignment
Range on Protein: 1490-1587
Range on HMM: 69-164/174.0
IVQFQVIGWMNDGVLRDPRtVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKaEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
..|.. ..|  .||  ..  .|.... | . ... .|||..||||  |.|||. .|. . | . . |..||.... ..|.. .||.|.| .||. .|.
giqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy

0051429 (Phosphotyrosine protein) phosphatases II 1490-1594 2e-16 56.0 In-house 122-226 (272) alignment
Range on Protein: 1490-1594
Range on HMM: 122-226/272.0
IVQFQVIGWMNDGVLRDPrtVLQVIDDVIHrqqkigGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVD--------VFQVTKALKRSKPGAVTTLEQ
. ... ..|  .|| ...  .|.... . .      |||..||||  ..|||...|. . |..  .| .||        .... . |..  |||| | ||
vmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeq

YITIYEALEMYLA
|. .||||  .| 
ylflyeallellr

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1490-1591 2.8e-16 53.9 In-house 91-192 (440) alignment
Range on Protein: 1490-1591
Range on HMM: 91-192/440.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. |..  || . || .    ||..|.|| . |.| | ||..||||  ..||||  |.   | ..|    .|.| . .... ..|  | | |||  ..||.
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

EM
  
le

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1338-1487 3.9e-16 54.0 In-house 46-201 (290) alignment
Range on Protein: 1338-1487
Range on HMM: 46-201/290.0
HEYINASYIHgYSKARKFIAAQGPMKKT-------LVDFWCLIWQEKPASVVMLTNLVEDSKT----KCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYV
 .|| |...  ...  ..|. | | .|.       . .|| .. |||  .|||| .  | |.      |..| |.  .|. .|. ..|   .     |  
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

IRNISVTLQDGsgEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMssSAKGPILVHCSAG
.|.. |. .|.  | . .| . |  | .  |.|    |..| . |.    | |..|||  |
tRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdG

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1365-1487 4.1e-16 53.8 In-house 40-158 (255) alignment
Range on Protein: 1365-1487
Range on HMM: 40-158/255.0
TLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEdyVMPDYVIRNISVTLQDG-SGEVHALTQYHLTTWPDHGVPEYATP
|.  |.  | | |.  ||||... |... ||..|.|  ..|  ..   .||  .   . | |.| . .|.. |   . | .. |. . |...  || |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LMTLHKRVMSSsakGPILVHCSAG
.. . | |  |    ...||||.|
ilnilkvvrds...ksvvvhCstG

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1490-1594 4.9e-16 53.5 In-house 154-265 (270) alignment
Range on Protein: 1490-1594
Range on HMM: 154-265/270.0
IVQFQVIGWMNDGVLRDPR------TVLQVIDDV-IHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQY
.| |.   | ..|| |..        .|... .|  .....  ..|..||||. | |||.  |. ||..  . .. ||| .. ..|.. ..  | . |||
lvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqy

ITIYEALEMYLA
  .|.|. .|  
eflykavveyae

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1490-1589 7.7e-16 52.6 In-house 176-275 (439) alignment
Range on Protein: 1490-1589
Range on HMM: 176-275/439.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..||. | | .  |  .   ||. .  .   ..|   ||.|||||  | |||   |. ||||| |.|  ||.  . | |.. .   | .| ||. ||.|.
vlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav





subfamily_PTPN13_pd Subfamily PTPN13 1489-1590 1.2e-15 52.5 In-house 167-266 (273) alignment
Range on Protein: 1489-1590
Range on HMM: 167-266/273.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkiGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
...... . | . || . .  .||..  | . |.    ||||||||  . |.|.. .| ..|.  . .  .|| .. . |.. . | | | .||| .|.|
evahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyka

LE
. 
il

0041856 (Phosphotyrosine protein) phosphatases II 1490-1595 1.3e-15 53.0 In-house 79-173 (182) alignment
Range on Protein: 1490-1595
Range on HMM: 79-173/182.0
IVQFQVIGWMNDGVLRdPRTVLQVIDDVIHrqqkiGGGPIVVHCSDTVSRTGVYCAISIALEQckaeGvVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..|.. ..|  .||   ....|. |..|..      |||..||||  |.|||...|. . ...    | |..... | ... .||.|.|..||. .. ||
giqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlal

EMYLAI
 ..|  
lellll

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1519-1592 1.6e-15 51.9 In-house 185-258 (267) alignment
Range on Protein: 1519-1592
Range on HMM: 185-258/267.0
HRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALEMY
. | . |. |.||.||| | |.| .  |   ||. | |||.|.|.  . ..  ..| | |.|.|| |.| |  |
knqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

0043147 (Phosphotyrosine protein) phosphatases II 1490-1588 1.9e-15 52.4 In-house 65-156 (172) alignment
Range on Protein: 1490-1588
Range on HMM: 65-156/172.0
IVQFQVIGWMNDGVLrDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALeqckaeG-VvDVFQVTKALKRSKPGAVTTLEQYITIYEA
..|.. ..|   ||  ... .|.... . .....  |||..||||  |.|||. .|. . |        . ..... . ... .||||.. .||. .|. 
giqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyyf





subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1489-1593 8.8e-15 49.6 In-house 171-276 (281) alignment
Range on Protein: 1489-1593
Range on HMM: 171-276/281.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRSKPGAVTTLEQYITIYE
...|.. . | . ||  ... .|.  ..| . ..|    |.|.|||  | |||.| |.  ......||   .|| .| . |....   | |. ||  .| 
eveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvyk

ALEMYL
|.  .|
avldal

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1490-1588 1.9e-14 48.5 In-house 135-234 (237) alignment
Range on Protein: 1490-1588
Range on HMM: 135-234/237.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKI-GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
| |.|   | . || .   ..|.   ..|.| ...   || ..|||  | |||..  |   | |.| . |||...  ....  .|  . | .||. |...
ihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt





subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1352-1490 5.7e-14 46.7 In-house 4-148 (199) alignment
Range on Protein: 1352-1490
Range on HMM: 4-148/199.0
ARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDG-SGEVHALTQYHLT
 |..||.| |...|. ||| ..|.     .||. .   . ..    ||| . .   ..| .|||     . |||.|  . .| .         ...| .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPDHGVPEYATPLM-TLHKRVMSS----SAKGPILVHCSAGWNI
.| ..  |. |  .   .  | .|         |..|||| |  .
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgf

subfamily_eak_pd Subfamily eak 1317-1469 5.9e-14 46.2 In-house 57-205 (332) alignment
Range on Protein: 1317-1469
Range on HMM: 57-205/332.0
FRNIVPYDDNIITLKLPGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTL
  .||||| . . |      .  ||||| .      ||.| .  . .. .  || .. ..|  ..|.| . ||    | ..|.|.   |  .|| . |. 
vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver

lEDYVMPD-YVIRNIsvTLQDGSgEVHALTQYHLTTWPDHGVPEYATpLMTLHK
  ..|  . .  |..   |. |  | | .  |..  | .  .| |   ...|.|
.kefvkrniletrll..elskGn.ethrvlhykvfGwtettlpkyed.flalrk

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1352-1490 6.8e-14 46.5 In-house 3-147 (198) alignment
Range on Protein: 1352-1490
Range on HMM: 3-147/198.0
ARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVMPDYVIRNISVTLQDG-SGEVHALTQYHLT
 |..||.| |...|| ||| ..|.     .||. .   . ..    ||| . .   ..| .|||     . |||.|  . .| .         ...| .|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPDHGVPEYATPLM-TLHKRVMSS----SAKGPILVHCSAGWNI
.| ..  |. |  .   .  | .|         |..|||| |  .
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgf

0048076 (Phosphotyrosine protein) phosphatases II 1490-1592 1.1e-13 46.6 In-house 47-142 (145) alignment
Range on Protein: 1490-1592
Range on HMM: 47-142/145.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKigGGPIVVHCSDTVSRTGVYCAISIALEqckaEGvVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
..|.. ..|   ||  .....|.... . . ...  |||..||||  |.|||...|. . |.    .| |..... . ...  ||||.. .|.. .||..
giqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefe

EMY
...
lel

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1490-1588 1.5e-13 45.5 In-house 138-235 (239) alignment
Range on Protein: 1490-1588
Range on HMM: 138-235/239.0
IVQFQVIGWMNDGVLRDPRTVLQVIdDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. |...  | . || .   .|| .    | ..   |  | |.|||  | ||| .  |   | |.| .  ||.|.  ||..  .|  | | |||. |. |
vyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1490-1588 1.7e-13 45.3 In-house 139-236 (239) alignment
Range on Protein: 1490-1588
Range on HMM: 139-236/239.0
IVQFQVIGWMNDGVLRDPRTVLQVIdDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. |...  | . || .   .|| .    | ..   |  | |.|||  | ||| .  |   | |.| .  ||.|.  ||..  .|  | | |||. |. |
vyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1267-1360 1.9e-13 44.4 In-house 4-95 (95) alignment
Range on Protein: 1267-1360
Range on HMM: 4-95/95.0
PISLNDLGNHVACCHSDSNAYFSEQFKDLYSGNDKQCSVGLNGMNKPLNRFRNIVPYDDNIITLKlpGVAQHEYINASYIHGYSKARKFIAAQG
|| .  .  ||   ||.|.  | ..|| .        .||    | | ||| ||.|||   ..|      . .|||| .. ||..   .|||||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt..tkrdsdyinacfvdgyarkncyiaaqg

0046846 (Phosphotyrosine protein) phosphatases II 1492-1592 2.1e-13 45.9 In-house 78-172 (176) alignment
Range on Protein: 1492-1592
Range on HMM: 78-172/176.0
QFQVIGWMNDGVLRDpRTVLQVIDDVIHRQQKigGGPIVVHCSDTVSRTGVYCAISialeQCKAEGVVDVFQVTKALKRSKP-GAVTTLEQYITIYEALE
|.....|   ||  . . .|.... .  ....  |||..||||  ..|||...|.      .. |  ..|... . ... .| |||.| |||  .||.. 
qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefel

MY
..
ll

subfamily_PTPN9_pd Subfamily PTPN9 1489-1592 3.1e-13 44.4 In-house 174-289 (297) alignment
Range on Protein: 1489-1592
Range on HMM: 174-289/297.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQ------------KIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAV
... ||...| . || ..  ..|.|.. | ..|             .. | |||||||  . ||| .... |.|.. . .|.|||... | |.  .  ..
kvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsi

TTLEQYITIYEALEMY
 | |||   | |.  |
qtpeqyefcylavley

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1490-1590 4.2e-13 43.4 In-house 134-233 (392) alignment
Range on Protein: 1490-1590
Range on HMM: 134-233/392.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQKIgGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEAL
. ||..  | ...| .   ..|..| .|     .    |...|||  | ||||  .|   . ..|   .||||..   ..| .|  | | |||  || |.
vaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav

E
 
l

subfamily_PTPN3_pd Subfamily PTPN3 1489-1588 4.6e-13 43.7 In-house 172-270 (280) alignment
Range on Protein: 1489-1588
Range on HMM: 172-270/280.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDViHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
.|.|.| . | . ||  |.  .|.... | .....    |.|||||  . ||||. .. .||    |.  | . .. . ..  .   | | .||  . ||
kilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea





0049260 (Phosphotyrosine protein) phosphatases II 1492-1587 5e-13 44.5 In-house 56-144 (152) alignment
Range on Protein: 1492-1587
Range on HMM: 56-144/152.0
QFQVIGWMNDGVLRDPRTVLQvIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALeqckaeGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
|.. . |  .||  ..  .|. . ..|.. ..  |||..||||  |.|||...|. . |        |..... . ... .||||.. .|.. .||
qylhlpwpDhgvpdlsqlllf.lllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

0051082 (Phosphotyrosine protein) phosphatases II 1488-1589 6.8e-13 44.0 In-house 58-149 (151) alignment
Range on Protein: 1488-1589
Range on HMM: 58-149/151.0
WNIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHrqqkIGGGPIVVHCSDTVSRTGVYCAISIALEQckaegvVDVFQVTKALKRSKPGAVTTLEQYITIYE
 .........| . |.   . .||.... ...     ..||..||||  ..|||. .|. . |..      |..... . .... ||.|.. .|.. .. 
ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

AL
||
al

fn3 Fibronectin type III domain 594-669 9.8e-13 41.2 Pfam-A 1-79 (85) alignment
Range on Protein: 594-669
Range on HMM: 1-79/85.0
SAPSSLTEVNKTATTITVNWNALD--SSDADGYVVNVTSDTDT--VQTVQVEGSSNnTITLNGLRAVTNYSITVRAYQQL
|||. |.  . |.|..|..|.. .  ... .|| | . .....   ....|..... . ||.||.. |.|...|.|. . 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga

subfamily_PTPN23_pd Subfamily PTPN23 1490-1589 1.7e-12 41.7 In-house 173-276 (288) alignment
Range on Protein: 1490-1589
Range on HMM: 173-276/288.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIH---RQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQC-KAEGVVDVFQVTKALKRSKPGAVTTLEQYITI
..  |.  | . ||   | |.||..| | .    .|.    |.|||||  | ||||.. .  |...  | .|..|. || . |.. .   | . ||.   
vshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfs

YEAL
||| 
yeav

0048179 (Phosphotyrosine protein) phosphatases II 1490-1587 1.8e-12 42.7 In-house 49-139 (144) alignment
Range on Protein: 1490-1587
Range on HMM: 49-139/144.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQkiGGGPIVVHCSDTVSRTGVYCAISIALeqckAEGvVDVFQVTKALKRSKPGAVTTLEQYITIYE
..|.. ..| . ||  ..  .|.... . . ..   |||..||||  |.|||...|. . .     .| ...... . ...  ||||.. .|.. ..|
giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle

subfamily_hpo-7_pd Subfamily hpo-7 1364-1487 2.7e-12 41.2 In-house 45-164 (263) alignment
Range on Protein: 1364-1487
Range on HMM: 45-164/263.0
KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTLLEDYVmpDYVIRNISVTLQDG-SGEVHALTQYHLTTWPDHGVPEYAT
.|.  |.  | | |.  ||||..  |... ||..|.|  ..|  ..   .|.  .     | ... . .. . |   ..| ...|  . |...  || | 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

PLMTLHKRVMSSsakGPILVHCSAG
  . . | .  |    .. ||||.|
eilnilkvarns...kslvvhcstG

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1358-1487 4.3e-12 40.1 In-house 96-231 (302) alignment
Range on Protein: 1358-1487
Range on HMM: 96-231/302.0
AQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNEIEQFGPFSVTL------LEDYV-MPDYVIRNISVTLQDGSGEVH-ALTQYHL
   | |.||  .|.|| | . | || |...||| . || .|. . ...  .|| ..|.       ||..    .... .. .. .    .|. ..   . 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TTWPDHGVPEYATPLMTLHKrvMSSSAKGPILVHCSAG
..||||| |. | . . . |     | |  .|||||||
sawpdhGapkeaytaldilk..fcesykknvlvhcsaG

0049772 (Phosphotyrosine protein) phosphatases II 1491-1594 8.5e-12 40.9 In-house 181-281 (314) alignment
Range on Protein: 1491-1594
Range on HMM: 181-281/314.0
VQFQVIGWMNdGVLRDPRTVLQVIdDVIHRQqkIGGGPIVVHCSDTVSRTGVYCAISIALEQCkaeGVvDVFQVTKALKRSKP-----GAVTTLEQYITI
...  | .   |   ... ..... ..|..     |||..|||.. ..|||..... . . ..   || .. .. . ...  |     |.. .||||. |
ikylripvpD.gsaplledfdefl.efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefi

YEALEMYLA
.|||..|| 
lealleylk

PTPc_DSPc_SM00012 1445-1489 4.6e-11 38.2 In-house 3-51 (105) alignment
Range on Protein: 1445-1489
Range on HMM: 3-51/105.0
TQYHLTTWPDHGVPEYATPLMTLHKRVMSSSAK----GPILVHCSAGWN
..|| |.||||||||.......| . |...  |    .|..||||||..
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvg

subfamily_PTPN14_pd Subfamily PTPN14 1490-1593 6.7e-11 36.7 In-house 185-296 (300) alignment
Range on Protein: 1490-1593
Range on HMM: 185-296/300.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDV---I-HRQQKI----GGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQ
.. .| . | ..|| .|... |. ...|     . ....       |..||||. | ||||     . ..  . . ..|. .| . |.. .   | || |
vwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaq

YITIYEALEMYL
|  .|..|  ||
YkfvYkvlikyl

subfamily_PTPRN_pd Subfamily PTPRN 1490-1588 6.7e-11 36.4 In-house 189-287 (297) alignment
Range on Protein: 1490-1588
Range on HMM: 189-287/297.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVIhRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQC-KAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
. ||  . | . ||   ....|.    |  .  .    |||||||| . |||||..| . |..  |    .|.    . |.  .|| | | .|.  .. |
vtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta





subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1347-1415 9.9e-11 35.6 In-house 230-294 (440) alignment
Range on Protein: 1347-1415
Range on HMM: 230-294/440.0
HGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEdsKTkCEQYWPQCLNEIeQFGPFSVT
.||||   |||.| |.  |..||| |. . . ....|| .| .  || |  |||     .  ||||.| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd..kt.csiywpvntrsv.tfgpftvg

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1490-1597 1.1e-10 35.8 In-house 170-281 (287) alignment
Range on Protein: 1490-1597
Range on HMM: 170-281/287.0
IVQFQVIGWmNDGVLRDP-----RTVLQVIDDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYIT
. |.... |  |.||        | ||.| . .  ...  . ||.|||..  . |.|.. |. . ... .  | ||| .|   |.  . . | .  |.  
vkqldllsw.PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrl

IYEALEMYLAINS
.||||  |   | 
lyealvtyyktnp

0044763 (Phosphotyrosine protein) phosphatases II 1492-1596 1.1e-10 36.9 In-house 77-174 (178) alignment
Range on Protein: 1492-1596
Range on HMM: 77-174/178.0
QFQVIGWMNDGVLRDPRTVLQVIdDVIHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQckaeGVvDVFQVTKALKRSKPgAVTTLEQYITIYEALEM
|.. |..  .||   .. .|... . |.. ..  |||..||||  |.|.|. .|. . ...    |. ..... . ... .| .|.. .|.  .||  ..
qylhipipDhgvpdllehflefv.efieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr

YLAIN
.|. .
llkes

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1334-1401 3.3e-10 33.8 In-house 86-155 (349) alignment
Range on Protein: 1334-1401
Range on HMM: 86-155/349.0
GVAQHEYINASYIH--GYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQ
.   ..|||| |..   .|  .|.|| | |.  |. ||. .|  ..   |. |..  | |  ||..|| .
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe

0048076 (Phosphotyrosine protein) phosphatases II 1407-1488 1e-09 33.8 In-house 11-92 (145) alignment
Range on Protein: 1407-1488
Range on HMM: 11-92/145.0
EQFGPFSvTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSSA-KGPILVHCSAGW
  .|..  | |.   . |. |. .     . .....  .||. . |||||||. .  |... . . .  . .||.||||||| 
lylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1526-1587 1.3e-09 32.5 In-house 134-197 (198) alignment
Range on Protein: 1526-1587
Range on HMM: 134-197/198.0
GGPIVVHCSDTVSRTGVYCAISIALE---QCKaEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
  |..|||||    |||. |. | .    . |   |||.|.|.| |.... | ...|..|  ||.
dapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1526-1587 1.4e-09 32.5 In-house 135-198 (199) alignment
Range on Protein: 1526-1587
Range on HMM: 135-198/199.0
GGPIVVHCSDTVSRTGVYCAISIALE---QCKaEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
  |..|||||    |||. |. | .    . |   |||.|.|.| |.... | ...|..|  ||.
dapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1529-1590 1.4e-09 32.2 In-house 1-62 (69) alignment
Range on Protein: 1529-1590
Range on HMM: 1-62/69.0
IVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALE
.|||||    ||| . || . . . |.| .||.|   . ... .|  |    .|| |..|| 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1494-1590 1.7e-09 31.7 In-house 189-280 (290) alignment
Range on Protein: 1494-1590
Range on HMM: 189-280/290.0
QVIGWMNDGVLRDPRTVLQVIDDVihrqqKIGGGPIVVHCSDTVSRTGVYCAISIALeQCKAEG-VVDVFQVTKALKRSKPGAVTTLEQYITIYEALE
... | .  |     ..|...  .     .   ||.|||||  . ||| . || ..| |.  .|  .|. .. .||..|. ..|    ||... |.| 
kikswpdksvalstlallrtlril.....rkasGpvvvhcsaGiGrtGtfvaievgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveill

fn3 Fibronectin type III domain 1065-1132 2.3e-09 30.4 Pfam-A 1-76 (85) alignment
Range on Protein: 1065-1132
Range on HMM: 1-76/85.0
DPPNNVTGFVINTNSIKVNWTNS----TETNGYVIEYTTGGGTR--NVVSTSEDE--IVLTNLSPMSTYTISVYSY
..| |..   ....|. ..|. .     .  || .|| . ||..  . .......   .||.| | ..|...|...
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1307-1457 2.3e-09 31.3 In-house 92-235 (244) alignment
Range on Protein: 1307-1457
Range on HMM: 92-235/244.0
LNGMNKPLNRFRNIVPYDDNIITLKLpGVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNlVEDSktkcEQYWPQClNEI
.|  |   ||    .|.| | . |   |     |||||..    .. ..| .| |.  | .||| .. . .   .|.|   ||.     ..|||.  . .
fnpnnswknregaglpfdfnrvplsk.gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywpds.epl

EQFG-PFSVTLLEDYVMPDYVIRNISVTlQDGSGEVHALTQYHLTTWPDHGV
| .    .||| .   . .    |. .   |      ||| . .. ||  | 
ewyeeditvtltdrdefknikasnleie.sdmneshqaltmfqisnwpsdgt

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1490-1595 3.7e-09 30.8 In-house 217-346 (350) alignment
Range on Protein: 1490-1595
Range on HMM: 217-346/350.0
IVQFQVIGWMNDGVLRDPRTVLQVID---DVIH----R--QQKIGGGPIVVHCSDTVSRTGVYCAISIALE------Q---------CKAEgVVD-VFQV
. |.||  | . ..| .|. .||...   |.|     .   ..  . ||.||||  | |||.....   |.      .           |. . | ....
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDlisii

TKALKRSKPGAVTTLEQYITIYEALEMYLAI
 . |.. .   | .|.|.| |||||  | |.
vnelrkqrismvqnldqfifiYeallfyfaL

0048179 (Phosphotyrosine protein) phosphatases II 1436-1489 7.2e-09 31.0 In-house 41-95 (144) alignment
Range on Protein: 1436-1489
Range on HMM: 41-95/144.0
DGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSS-SAKGPILVHCSAGWN
.   . .  .||. . |||||||.... | .. . . .  . .||.||||||| .
epefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvg

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1530-1590 8.2e-09 29.7 In-house 1-61 (69) alignment
Range on Protein: 1530-1590
Range on HMM: 1-61/69.0
VVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALE
|||||    ||| . || . . . |.| .||.|   . ... .|  |   ..|. |..|| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1480-1596 1.7e-08 28.2 In-house 210-347 (349) alignment
Range on Protein: 1480-1596
Range on HMM: 210-347/349.0
ILVHCSAGWNIVQFQVIGWMNDGVLRDPRTVLQV-------IDDVIHRQ--QKIGGGPIVVHCSDTVSRTGVYCAISIALE--QCKAEG--VV-------
||.  .  . ..|.||  |.. ..| .| ..||        |||   |.  ..    ...||||    ||||.. . . |.  .   .    .       
illavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallk

-DVFQVTKALKRSKPGAVTTLEQYITIYEALEMYLAIN
  .. .   |.. .   |  | |.|.|||||  |.|..
DlisiivnelrkqrismvqnlaqfiaiyealLkyfalk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1440-1487 3.7e-08 27.1 In-house 87-137 (440) alignment
Range on Protein: 1440-1487
Range on HMM: 87-137/440.0
EVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS---AKGPILVHCSAG
| ..| |||   |||.|||..| |.. . . |  |    ..||.|||||||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsag

subfamily_PTPN1_pd Subfamily PTPN1 1489-1588 8.8e-08 26.2 In-house 163-266 (290) alignment
Range on Protein: 1489-1588
Range on HMM: 163-266/290.0
NIVQFQVIGWMNDGVLRDPRTVLQVIDDVIHRQQ-KIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGV---VDVFQVTKALKRSKPGAVTTLEQYIT
.|..|  . | . || . | . |. . .| .    .   || |.|||  . |.| .| .   | . ....    ||. .|  .|.. . | . | .|   
eilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrf

IYEA
 | |
syla

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1497-1595 1.1e-07 26.2 In-house 180-273 (288) alignment
Range on Protein: 1497-1595
Range on HMM: 180-273/288.0
GWMNDGVLRDPRTVLQVIDDViHRQQKigggPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALEMYLAI
 | .|||  .  . |.... . .  ||    |||||.|  | |||    | ||||. . .  . . .. . |. ..  |..|  ||. ..  .  .|..
eWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1494-1586 1.3e-07 26.1 In-house 164-252 (290) alignment
Range on Protein: 1494-1586
Range on HMM: 164-252/290.0
QVIGWMNDGVLRDPRTVLQVIDDVIHRQqkiggGPIVVHCSDTVSRTGVYCAISIALEQCK-AEGVVDVFQVTKALKRSKPGAVTTLEQYITIY
.. || .  | .|..|.|..|. |  ..      |..||| | .||  .  || ..       .| | . .| |||.. .  |.|. ...  . 
llkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1496-1584 1.3e-07 25.4 In-house 196-279 (302) alignment
Range on Protein: 1496-1584
Range on HMM: 196-279/302.0
IGWMNDGVLRDPRTVLQVIDDVIHRQQKigggpIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYIT
 .| . |  ... | |...      ...     ..||||  | |||   ||   .. |. . | |. .. . ... . ||| . .| | 
sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1311-1395 2.6e-07 24.4 In-house 34-118 (332) alignment
Range on Protein: 1311-1395
Range on HMM: 34-118/332.0
NKPLNRFRNIVPYDDNIITLKlPGVAQHEYINASYIHGYSKARKFIAAQGPMK-KTLVDFWCLIWQEKPASVVMLTNLVEDSKTKC
|  .||   .  .| . . |  |   . .. |||.. ||||   .| || |.. .|   || .. . ||. .... .. |  | |.
nmdmnriphlycfdhsrvela.pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1490-1593 8e-07 23.4 In-house 178-277 (307) alignment
Range on Protein: 1490-1593
Range on HMM: 178-277/307.0
IVQFQVIGWMNDGVLRDPRTVLQVIDDVihrqqKIGGGPIVVHCSDTVSRTGVYCAISIALEQC-KAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEA
| ..|   | . || .   | . ... |     .    |.|||||  | |.|   |||.  ..  . .   |. .. . |.  .. |. |  ||. ..  
iqhlqwenwpdrgvpqinltainlleav.....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrv

LEMYL
|  |.
lleyf

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1311-1475 1.1e-06 22.3 In-house 51-214 (302) alignment
Range on Protein: 1311-1475
Range on HMM: 51-214/302.0
NKPLNRFRNIVPYDDNIITLKlpgVAQHEYINASYIHGYSKARKFIAAQGPMKKTL---VDFWCLIWQEKPASVVMLTNLVEDSKtKCEQYWPQCLNEIE
|   |.  ..  .|.|.. |.    .. .|.||| ..  .  |. | || | ...     .|| ...||| .|||.|    | .|   ....|.  .. .
nlkknqsedvpildsnlvkle...aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyk

QFGPFSVTLLEDYVMPDYVIRNISVTLQDGSGEVHALTQYHLTTWPDHGVPEYATPLMTLHKRVMSSS
..| . |       . . . | .   | .|  .    . |.|| |... ||.  . |..  . |  ..
eygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1518-1589 2e-06 21.6 In-house 192-265 (281) alignment
Range on Protein: 1518-1589
Range on HMM: 192-265/281.0
IHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAE-GVVDVFQVTKALKRS-KPGAVTTLEQYITIYEAL
| |. .    | |.|||  | |.|   |. |||.  ..   . |. |.   |. . .  .| ||.||. |.. |
ilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1314-1463 3.4e-06 20.9 In-house 50-192 (303) alignment
Range on Protein: 1314-1463
Range on HMM: 50-192/303.0
LNRFRNIVPYDDNIITLklpgvAQHEYINASYIHGYSkARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTNLVEDSKTKCEQYWPQCLNeIEQFGPFS
 ||| ...  |   . |     ..  || |||..  |  .| | .| |. .|  ||| .| ..|   |..|    |  |   .  .|.  . . .|   |
knrfvdvicldhskvkl.....sdssyihasylelds.skkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.flkfeers

VTLLE---DYVMPDYVIRNISVTLQDGSGEVHAltqYHLTTWPDHGVPEYATP
. . |     ..  .|.. .||.  |    .|    .|  .||   .|  ..|
irvgefkrvelgdgwvlkvlsvsngdyksflhv...hhykawphnsipsdgsp

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1524-1587 4.7e-06 20.4 In-house 221-284 (310) alignment
Range on Protein: 1524-1587
Range on HMM: 221-284/310.0
IGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYE
.  || |||||  . |..| .|. ..... .    ||. .|   |..|.   . |  ||. |  
vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1334-1456 4.8e-06 20.9 In-house 9-125 (130) alignment
Range on Protein: 1334-1456
Range on HMM: 9-125/130.0
GVAQHEYINASYIHGYSKARKFIAAQGPMKKTLVDFWCLIWQEKPASVVMLTnLVEDSktkcEQYWPQClNEIEQFGPFSVTLLEDYVMPDYVIRNISVT
 . ...|||||..    ...... .| |. .| .||| .. .     .|.|   ||.     ..|||.  . .| .    .  | |    ...  .    
rlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg.sveee....deywpds.ePlewyeediivtltdrdefknikasnlei

LQDGSGEVHALTQYHLTTWPDHG
 .|     .||| .... ||  |
esdlneshqaltmfqisnwpsdg

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1497-1594 7.9e-06 19.5 In-house 190-286 (302) alignment
Range on Protein: 1497-1594
Range on HMM: 190-286/302.0
GWMNDGVLRDPRTVLQVIDDViHRQQKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVDVFQVTKALKRSKPGAVTTLEQYITIYEALEMYLA
 | .. |.    .. . . .| . ..  .  ..|.     . | |.  .  .|.|. ...  . . .. |...  .| || .|.||...| || .|. 
nWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1492-1591 8.2e-06 19.8 In-house 190-285 (305) alignment
Range on Protein: 1492-1591
Range on HMM: 190-285/305.0
QFQVIGWMNDGVLRDPRTVLQVIDDVihrqqKIGGGPIVVHCSDTVSRTGVYCAISIALEQCKAEGVVD-VFQVTKALKRSKPGAVTTLEQYITIYEALE
..  | | . ||     ..|... .      .   ||||||||  . |||    .   |.|  |  ...   .. . ..  .  .. | .||. ... . 
hyhwidwpdrgvpaadlailelleka.....rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvil

M
 
n