Gene PTPRD-70 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP129_AA protein Get Run
AqueP129_AA_1011-1291 phosphatase_domain Get Run
AqueP129_AA_1303-1576 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1011-1296 3.3e-129 424.9 In-house 2-299 (301) alignment 
Range on Protein: 1011-1296
Range on HMM: 2-299/301.0
LEDLGTHVANCHTDNntlFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTL
|||||||||..|...   | ||||....|||||...|.|.|||..|||.|||.||||||.|.|.|.||.||..|.|||||||||...||||.|||||.||
ledlgthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktl

VDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSN--------------DSHTLTQYHLTSW
||||||||||||||||||||||||||||||||||||. ....||||||||.|||||||||||||||||..|||              .|....|...|.|
vdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdW

PDHGV-PDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDT
|..|| ....| |...............||..||||..|.|.|......|.|||.|.|||||. ......|......|.||.||....|.. ..... .|
pqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst

E
.
y
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1316-1583 2.1e-125 412.4 In-house 12-301 (301) alignment 
Range on Protein: 1316-1583
Range on HMM: 12-301/301.0
TGCSGLQSQFELLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVS
.   ....|.. |....... .| ....... ................. |.|     . ||||||..||.|||.||.||.||..| .|||..|...|..
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

AIVMLCGLEEDGEESCYQYWRDSDVVQFGEYFIKVEFSKEC-------------------NGYIERKFHIRSDKdeSSWDVIQLQVTDWPQDGVVREPRT
.|||...|.|. ...|.|||..|.  .  .....|....|.                   ||||||||...|||  |||||.||||||||||||||||||
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprt

VLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINSTYAN
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..|..||||||
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1007-1310 1.6e-123 406.8 In-house 2-303 (305) alignment 
Range on Protein: 1007-1310
Range on HMM: 2-303/305.0
LPIALEDLGTHVANCHTDNNTLFGEQYKAIYNGeDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPM
 .|||.|| ... . ...... . .|||..|.  ..|. .| ...||  ||...||..||.|| ||. ..||  .. | ||||.|||... |.|..|||.
kiialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPl

KRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYAT
| |..||||||..||...|||.|.|.|| |.||.||||.|.... .||.|.|.| .|. ..|...|.|.. | .....|.|..||.||.|||||||..||
kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

PLMSLHKQVMATWSPSKG-PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMK
 |.|| |.|. ... .|| |.||||||||||||.|||.|||||..|.|.|||. .....||..|||||||||||||||||. | . ||||.|  . ....
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar

LRELK
.  ||
vnklk
subfamily_PTPRD_pd Subfamily PTPRD 1008-1367 3.1e-123 407.4 In-house 4-359 (564) alignment 
Range on Protein: 1008-1367
Range on HMM: 4-359/564.0
PIALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLdkCQTTYTNASYIDGYSNRTKFIASQGPMK
||  ..| .|||. ...... | |.|| | .|.  ..     ..||  ||. ||..|| .|.||.. ..    .. | |||.|||| .| ..||.|||..
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPla

RTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNStGdNDHFGPFTVTLINEQVYPDFVIRQLNVkIYNGSNDSHTLTQYHLTSWPDHGVPDYATP
.|. ||||..|...  .|||.|.|.| .| ||..|||.. | . ..| .|||| .|. . |..||....   . |..|.. .|.| |||||||||..||.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesats

LMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMKLR
|..| ..| |...| .|||.||||||||||||||.||. ||..| |..||| ..|..||.||  |||| .||.|.|.|.|| . ||.||..|......|.
lLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlq

ELKEIDSSTGCSGLQSQFELLSQVTPDPDDVFCD-SAKAHSDKNRSTSYLPQENFLVTLKE
.|.|... |. .||.  |. |.  .... . |     .  ..||| .  |. |.  |.|. 
kLaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsa
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1316-1577 6.2e-97 319.4 In-house 19-285 (305) alignment 
Range on Protein: 1316-1577
Range on HMM: 19-285/305.0
TGCSGLQSQFELLSQVtPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKENNG---YINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAI
. ..||. |...| .  ... || ...|.......... .|... . .| ||...   ||||||. ||..||..|.||.|..|| .|||..||..||| |
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLCGLEEDGEESCYQYWRDSDVV--QFGEYFIKVEFSKECNGYIERKFHIRS-DKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGG
|||..| |.|.. |.||| .|     .|||. .... .|. ..|||||..|   |.|. |  |.|.|.||||..||.... ..|..|..| ..|.|  | 
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv

PVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAI
|..||||..|.|.||...|.| ||..|.|.|||||.|.|..|......|.||.||....|..|. .  
pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1008-1325 8.6e-97 319.0 In-house 4-318 (319) alignment 
Range on Protein: 1008-1325
Range on HMM: 4-318/319.0
PIALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMK
.| ...| ... . ..  .||. ...| . .......     .|||  ||..|| .||  |.||.. ..  . ...| |||.|||| .|.|||| |.|..
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqaPle

RTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNStgDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATP
 |. ||||..|.|.   .||.|.|.|  | |...|||.   .  ..| ..||| .|.   |..||.|.... ..  .. ...... |.||||.||..|| 
ntiedfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

LMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMKL
|. | |..  ...  ..||| ||||||||||||||..|..||. |.|||.|.  .|.||| ||  |||. .|| |...|.|| | .|||||  .. ...|
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl

RELKEIDSSTGCSGLQSQF
..|.| .. || .||. .|
kqlaekvadtgetgleref
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1009-1292 1.4e-96 317.8 In-house 2-285 (290) alignment 
Range on Protein: 1009-1292
Range on HMM: 2-285/290.0
IALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDKSTV-IGFSQENKVYNRFRNITPYDDNRIVLTPWPQLDKCQTTYTNASYIDGYSNRTKFIASQGPMK
| ....| .||| |. .|. | .|.|.. .|| . || .|....||  |||.|| .||||||.| | ..   |.  | ||.||.||... ..|| |||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

RTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNStgDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHG-VPDYAT
.||||||.||||||   |||.|| .|  | || ||||.|  |....|.|...|.||... ....|.|.||  | .......|||..|.|...| |....|
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

PLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMC
 |.......   . . ...|.||||..|||...|.|........| |||.|.  .....|.|....||| .|| .... ||. . .
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1009-1326 4.6e-96 316.6 In-house 2-316 (318) alignment 
Range on Protein: 1009-1326
Range on HMM: 2-316/318.0
IALEDLGTHVANCHTDNNTLFGEQYKAIYNG-EDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMK
| .||| .||.. ... ..|. |.|...    |  ...   .. ||  ||. ||..||. |. |..  . .. .. | ||.||||| .. ..||.|.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqm..legeegsDyinanyidGyrrkkayiaaqaPlp

RTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTgdNDHFGPFTVTLINEQVYPDFVIRQLNVKIyNGSNDSHTLTQYHLTSWPDHGVPDYATP
.|. ||||..|. .   |||.|...| .| |...|||..     ..|  .|.| .|  . |.|.|...|.  .....| .  ||| |||||.|||. .. 
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgas

LMSLHKQVMATW-SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMKL
|..| .|| ..  ....|||.|||||||||||.|||.|| ||..| |..||. ..|..||.||  |||| |||.|..|..|| ...||||. ...   ..
lldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsri

RELKEIDSSTGCSGLQSQFE
|||.| |. .| . .. .|.
relreqdpesgttemdaefq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1009-1296 9e-94 308.6 In-house 2-284 (287) alignment 
Range on Protein: 1009-1296
Range on HMM: 2-284/287.0
IALEDLGTHVANCHTDNNTLFGEQYKAIYN-GED-KSTVIGFSQENKVYNRFRNITPYDDNRIVLTpwpqldKCQTTYTNASYIDGYSNRTKFIASQGPM
|..| .|  ||. |  .|. | .|.. . . ... ..  .. ...||  ||...| ..|..|..|       ...  | ||..||||... .||....||
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPm

KRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGdnDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHG-VPDYA
 .|...||.||.....  |||....|| ....| ||||...     .|.....|.||.|. ....|.|.||  | ..| ....||..|.|...| |....
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepq

TPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTE
| |. ..... .   .....|.||||..|||...|.|........|.|||.|.  .... |.|....||| .|| |. |.||| . ...| 
tillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
0051299 (Phosphotyrosine protein) phosphatases II 1008-1290 3.8e-93 307.4 In-house 4-286 (288) alignment 
Range on Protein: 1008-1290
Range on HMM: 4-286/288.0
PIALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDK-STVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPM
.| .|.|  .| . . ...|.. |.......   . .. ..  .||.  ||...| |||..|..|.....     ..| |||||||| .  |||| |||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPl

KRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNstGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYN---GSNDSHTLTQYHLTSWPDHGVPD
. |. ||||..|...   |||.|.| |  . ||.||||.  |.   .|..||||..|.|..|...|.| |. ..   |.. |.| |..| |.||||||||
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

YATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
....|... ..|.   ....||..|||||||||||||||.|..||| ..||.||. ..|.|||.||. ||||..||.|...|.|| .
spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 1016-1325 2.8e-92 304.7 In-house 7-311 (317) alignment 
Range on Protein: 1016-1325
Range on HMM: 7-311/317.0
THVANCHTDNNTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWR
 ..  ..  ..|.. |... ...    .. ..  .||| .||...| |||..|..|.| .      ..| ||||.||.. ..|||| |||.. |. ||||
lalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

LIWQEKPVSIVMVTNLKEGTKSKCEQYWPNstGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYnGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV
..|...  .|||.|.|.|  . ||.||||.  |.  ..|.|||||..|........|.| |. . |...|.|.|..| |.|||||||.. ..| .. ..|
mvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleav

MATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMKLRELKEIDSS
 .  ....||.||||||||||||||||....||| ..|| ||.  .|..||.||...|||..||.||.||.|| .....| .| .|. .|| .|....  
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplal

TGCSGLQSQF
.. .. ....
ddvklkekel
0050432 (Phosphotyrosine protein) phosphatases II 1002-1295 3.2e-92 304.4 In-house 19-304 (308) alignment 
Range on Protein: 1002-1295
Range on HMM: 19-304/308.0
YIPVTLPIALEDLGTHVANchTDNNTLFGEQYKAIYNGEDKST-VIGFSQENKVYNRFRNITPYDDNRIVLtpwpqldKCQTTYTNASYIDGY--SNRTK
. ...|.. ..||  .. .   ....|. |.......  .  .  ..  .|||  ||...| ||| .|..|       .  ..| ||||.|||   .. |
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprk

FIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTG-DNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSnDSHTLTQYHLTSWP
||| |||.. |. ||||..|...   |||.|.| |  . ||.||||...| .  ..|.|||||..|.|..|...|.| .. .... .|.|.|..| |.||
fIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWp

DHGVPDYATPLMSLHKQVMATWspSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDT
|||||.....|... ..|  .   ..|||.|||||||||||||||.|..||| ..|| ||. ..|..||.||. ||||..||.||..|.|| ...  |
dhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
subfamily_PTPRB_pd Subfamily PTPRB 1007-1291 1e-91 302.0 In-house 5-286 (293) alignment 
Range on Protein: 1007-1291
Range on HMM: 5-286/293.0
LPIALEDLGTHVANCHTDNNTLFGEQYKAIYN-GEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWpqLDKCQTTYTNASYIDGYSNRTKFIASQGP
 || ||.. .||.. ..|... | |.|. . . |.|.....  ...|.  ||..|| ||| .|. |..    |. .. | ||.||.||. . .|||.|||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaal..kdesgsDYinanyipgynsprefiatqGP

MKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNdHFGPFTVTLINEQVYPDFVIRQLNVKIyngSNDSHTLTQYHLTSWPDHGVPDYA
.  |. ||||..|..|   |||.|.| |. | |||.|||. . .   .|  .|||..|... |.|||.|...    ........||| |||||||||. .
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPekt

TPLMSLHKQVMATW--SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM
..|... ..|  .   . ||.||.|||||||||||||||.|  |.. ..| .||| ||| .||..|. .||| .||.|.|..||. ..
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1306-1584 1.5e-91 301.4 In-house 7-287 (287) alignment 
Range on Protein: 1306-1584
Range on HMM: 7-287/287.0
LRELKEIDSSTGCSGLQSQFELLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKE-NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMI
. |. . .  .|  | . || .| ||| ..|.|  . |.   ||||.|  |...|. | ||. .. ||||... ||.||||||||.||| ||||.|||.|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkli

VDYKVSAIVMLCGLEEDGEESCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDK-DESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ
 | .|.|||||| ..|. || ||||| ... | .||| |..   .  .||||||.... .. ...   | | |.|.|.. | | ||.|.| ||.. .. |
ddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINSTYANF
.| | ...|||||||| ||...|.. .....|| |||.||||| |  |  |||.| | |||. |.|.. ..|   .||..|
rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
0036941 (Phosphotyrosine protein) phosphatases II 1025-1301 1.5e-89 295.5 In-house 11-288 (297) alignment 
Range on Protein: 1025-1301
Range on HMM: 11-288/297.0
NNTLFGEQYKAIYNGEDKS-TVIGFSQENKVYNRFRNITPYDDNRIVLtpwpqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPV
...|. .... ...      . .. ..||.  ||...| |||..|..|      |.  . | ||||.|||.   |||| |||.. |. ||||..|...  
flalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

SIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQV--YPDFVIRQLNVKIYnGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TW
.|||.|.| |  . ||.||||. .|.   .|.|||||....|  ..|...|.| |. . |...|.|.|..| |.|||||||.....|... ..|      
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

SPSKGPILVHCSAGVGRTGTFIAIDIALEQAK---REGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNE
.||.||.||||||||||.|||||.|..|.| .   .|| |||  .|. ||.||. .||||.||.||..|.|| .....| .| ..
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
subfamily_PTPRK_pd Subfamily PTPRK 1009-1326 5.1e-89 293.2 In-house 4-313 (314) alignment 
Range on Protein: 1009-1326
Range on HMM: 4-313/314.0
IALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDKSTvigfSQENKVYNRFRNITPYDDNRIVLTPWpqLDKCQTTYTNASYIDGYSNRTKFIASQGPMKR
|  .||  ..|  .. ..  | |.|.....| | .      .||.  ||. .| .||  |..|..    .  .. | ||..||.| . ..||. |||.. 
irvadllqsiallkraegygfkeeyeslfegwdaak....kdenreknrsgdilaydrsrvfliti..dgdpssdyinaalidsykrpaafivtqgPlqe

TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTgdnDHFGPFTVTLINEQVYPDFVIRQLNVKI-YNGSNDSHTLTQYHLTSWPDHGVPDYATP
|. |||||...|.  ||||.|.|.| .. || .|||. |   ...|.. |.|.. ..  ..|.| ..|.    | .. ... |.. ..||||.|| .|| 
tvkdfWrlvydencasivmltelvevgrvkClkyWPedt...evygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatg

LMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMKLR
|..| ..| ..  ...|.|.|||||| ||||||||||| |. ..||||||.  .|  ||.... ||.| .||.|..|..||...||.| ||  |..    
llklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyl

ELKEIDSSTGCSGLQSQFE
| ...|. |  | |. .|.
esirldpqtnssqlkeefq
0046845 (Phosphotyrosine protein) phosphatases II 1031-1296 7.2e-89 293.2 In-house 4-280 (284) alignment 
Range on Protein: 1031-1296
Range on HMM: 4-280/284.0
EQYKAIYNGEDK---STVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQlDKCQTTYTNASYIDGY-----SNRTKFIASQGPMKRTLVDFWRLIWQEKP
|.......   |   |. ..  .||.  ||...| |||..|..|..... |   ..| ||||.|||      .. |||| |||.. |. ||||..|... 
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

VSIVMVTNLKEGTKSKCEQYWPNStGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS--
  |||.|.| |  . ||.||||.. |.  ..|.|||||..|.|..|...| | .. .. .. |.|.|..| |||||||||.....|... ..|    .  
rvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

PSKGPILVHCSAGVGRTGTFIAIDIALEQAKREG---VVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTE
|..|||.|||||||||||||||.|..||| ..||   .||. ..|.|||.||. |||||.||.|...|.|| .... | 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0039614 (Phosphotyrosine protein) phosphatases II 1009-1295 1.6e-86 285.7 In-house 14-294 (297) alignment 
Range on Protein: 1009-1295
Range on HMM: 14-294/297.0
IALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDKsTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLDKcQTTYTNASYIDGYSN-RTKFIASQGPMK
| |. |  ..   . ...||. .... ...  .  ..|. ..|||  ||...| |||..|..|.| .  |   ..| ||||.|||.    ||||.|||..
iplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlp

RTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNSTGdndHFGPFTVTLINEQVYPDFVIRQLNVKIyngSNDSHTLTQYHLTSWPDHGVPDYATP
 |. ||||..|...  .|||.|.|.|  . ||.||||...|    .|.|||||...........|.|.|.    .. |.|.|... |.|||||||.... 
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslel

LMSLHKQVMATWS--PSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDT
|... ..|.   .  |..||.||||||||||||||||....||| ..|| ||.  .|..||.||...|||..||.||.||.|| .....|
lleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_PTPRA_pd Subfamily PTPRA 1007-1325 5.9e-86 283.3 In-house 12-330 (330) alignment 
Range on Protein: 1007-1325
Range on HMM: 12-330/330.0
LPIALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDKSTVIGF-SQENKVYNRFRNITPYDDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGP
 |. .|.|   .    .|.| || |...|.  |. ..|.     .|||  ||. || ||| .|..|..     . .. | |||.|||| .. ||||.|||
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeG..veesdyinasfidGykekdkfiaaqGP

MKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNStGdNDHFGPFTVTLINEQVYPDFVIRQLNVK-IYNGS--NDSHTLTQYHLTSWPDHGVP
 ..|. ||||.||. |  .|||.|.|||  ..||.||||.  |    .|  .|.. .|.|  |. .|.. |. . ...  ..|  ..|.|.||||| |||
keetvedfwrmiweqksativmltelkerkeekcaqywPde.G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvP

DYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEY
  .  ...| |.| ..   | ||| ||||||||||||||..|  ||. | |..||. ..|.|||.|| .||||. ||.|.. ..||  . ||||.     
fepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssl

EMKLRELKEIDSSTGCSGLQSQF
| .|..|..  ..|   ||. .|
ekhlqklynkitgtdkigleeef
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1008-1326 1e-85 282.5 In-house 5-315 (315) alignment 
Range on Protein: 1008-1326
Range on HMM: 5-315/315.0
PIALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLtPWPQLDkCQTTYTNASYIDGYSNRTKFIASQGPMK
|| |..| |.||. ..  .  | ..|..|  |. .   .    |||  ||. || .||  |. | |  . |  .. | ||..||||. . ..||.|||  
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvql.pllend.phsdyvnanfidGynkkrryiaaqgpnv

RTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNStgdNDHFGPFTVTLINEQVYPDFVIRQLNVKIynGSNdSHTLTQYHLTSWPDHGVPDYATP
 .. |||||...|.   |||.||| || |.|.|.|||.    .  .|..|||...|.|. .. .| | |    |.|  ... |.|.||||| ||| |..|
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvf..gdn.irevvqlhytswpdmgvpkytip

LMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMKLR
|| |...|.     | |.|.||||||||||||||..|  |.||. | ..|.  .....||.|.||||...|| |..||.|||..|||| |  . |  .  
lmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryd

ELKEIDSSTGCSGLQSQFE
 |      || . || |||
sllapspdtgstllqeqfe
0047943 (Phosphotyrosine protein) phosphatases II 1023-1289 1.2e-85 282.6 In-house 8-271 (273) alignment 
Range on Protein: 1023-1289
Range on HMM: 8-271/273.0
TDNNTLFGEQYKAIYNGEDKST-VIGFSQENKVYNRFRNITPYDDNRIVLtpwpqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEK
 ...||. |.......  .  |  ..  .||| .||...| |||..|..|      .   . | ||||.|||    |||| |||.. |. ||||..|...
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

PVSIVMVTNLKEGTKSKCEQYWPNSTGD-NDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNdSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS
   |||.|.| |  . ||.||||.. |.    .|.|||||..|....|...|.| .. .. .. |.| |..| |.|||||||.. ..|... ..|. . .
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkale

P--SKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLET
   |.||..|||||||||||||||.|..|.| ..|| ||.  .|..||.||. ||||..||.||..|.|| 
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 1003-1291 1.3e-85 283.1 In-house 3-305 (307) alignment 
Range on Protein: 1003-1291
Range on HMM: 3-305/307.0
IPVTLPIALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDK---STVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLdKCQTTYTNASYI--------D
.|. |.| ...|  .|.  . |..|.. .... ... ...   .. |. ..||| .||...| |||..|..|.. ..     . | ||||.        |
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllld

GYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNStGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNDSHTLTQY
|| . .|||| |||.. |. ||||..|...   |||.|.|.| .. || ||||.. |.   .|.|||||..|........|.|.|. ..|.. |.|.|..
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthf

HLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGV---VDIGGIVNRLRQQRMKMVQTLDQYVFLHDAV
| |.|||||||..  .| .. ..|..   ..|..||.||||||||||||||||....|.| ..||.   ||.  .|..||.||...||...||.||..|.
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

LETVM
|| ..
lelll
0043336 (Phosphotyrosine protein) phosphatases II 1010-1288 3e-85 281.3 In-house 3-275 (278) alignment 
Range on Protein: 1010-1288
Range on HMM: 3-275/278.0
ALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLDKcqTTYTNASYIDGYSNRTKFIASQGPMKRT
  .||  ...... ...||. .... ...    .. |. ..|||  ||...| ||| .|..|.. .      ..| ||||.|||.  .||||.|||.. |
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpet

LVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPnstGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIyNGSNDSHTLTQYHLTSWPDHGVPDYATPLM
. ||||..|...  .|||.|.|.|  . || ||||   |.   .|.|||||..|....|...|.|.|.  .|.. |.| |.|| ..|||||||.  ..|.
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslslll

SLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
.. |.|.   ..|.||.||||||||||||||||....|||...|| ||.  .|..||.||...|||..||.||..|.||
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 1008-1308 3.3e-85 280.9 In-house 3-304 (307) alignment 
Range on Protein: 1008-1308
Range on HMM: 3-304/307.0
PIALEDLGTHVANCHTDNNTLFGEQYKAIY-NGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPM
.||..|| . . . . | . .. . |. .  .  ||||...  .||.. ||. .|...|..|..|.. .  .  ...| |||.| || .. ||||.|.|.
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPv

KRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNStgDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYN--G--SNDSHTLTQYHLTSWPDHGVP
  |. ||||.|.. .   |||..||.| .. ||..|||.   |. ..|   |.|..|.  .|..||.|.|   .  .   .||. ..||| |.|.|  ||
eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP

DYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEY
. |. |. | .||    . ...||.|||||||||.|.|.|.|. |.| | |  |||  .|  ||.||  .|| |.|||||. |.|.. . |||..  ...
evargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddl

EMKLRE
| ....
edaier
subfamily_PTPRG_pd Subfamily PTPRG 1011-1303 1.1e-84 279.6 In-house 3-300 (563) alignment 
Range on Protein: 1011-1303
Range on HMM: 3-300/563.0
LEDLGTHVANCHTDNNTLFGEQYKAIYNGEDKS-TVIGFS--QENKVYNRFRNITPYDDNRIVLTPWPQLDKCQtTYTNASYIDGYSNRTKFIASQGPMK
....  |||..|.|... | |...|. .   ..   . .|  .|||  ||  ||..||  |. |.| |  .|    | ||.|||||    .|||.|||.|
vkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgplk

RTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNstGDNDHFGPFTVTLINEQVYP-----DFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVP
 |. ||||.||...   |||.|||.| .. ||..|||.   .  ..| ..||||.|.|        .||..|..|  .  .. .. .||| |.|||||||
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

DYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEY
....| ..  |.  |.     |||.||||||||||||.|..|  |.| ..| .|.. |.. ..| ||  .||| .||.|||||.||... ..||. ... 
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

E
|
e
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1014-1289 1.2e-84 278.8 In-house 9-278 (288) alignment 
Range on Protein: 1014-1289
Range on HMM: 9-278/288.0
LgTHVANCHTDNNTLFGEQYKAI-YNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPMKRTLVD
. ..||. . .|.| | |.|...   ...||. .|   .|.  ||.||| ||| .|. |.  .. .  .. | |||||||. .. |.||.|||.  |. |
v.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyidgekkkkkyiatqgPladtvnd

FWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNStGDNDHFGPFTVTLINEQVYPDFVIRQLNVKiynGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLH
||.|....|   |||.|.| || |.|||.|||.. ... ..| .||||....   ||| |.| ..    ...  ..|||. ..|||||||. ..||. | 
fWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllell

KQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLET
.||  . .   |||.|||||||||||||||.| .... ..| ..|. |.|..||.||. .|||| ||.|.....|. 
rqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1313-1580 6.9e-84 276.1 In-house 14-288 (290) alignment 
Range on Protein: 1313-1580
Range on HMM: 14-288/290.0
DSSTGCSGLQSQFELLSQvTPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLK---E----NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIV
. ..| .| ..||. | . .  .  |  . ..  . .||.. ....... .||.   .    .| ||||.|. ||.|||..|..|.|..||..||||.|.
ghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliw

DYKVSAIVMLCGLEEDGEESCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKD-ESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ
. ||..||||.   |.|.. |.||| |||. ..||. ||.   ...|.|||||.......  ...  |.|.|.| |...| | .| |.|.||  ... | 
qekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqr

KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINST
| | ...||||||||.||.|.|.. .....|| |||.||||| |  |  ||| |.| .||  |.... . |   .|
krgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1019-1297 1.1e-83 276.0 In-house 19-297 (298) alignment 
Range on Protein: 1019-1297
Range on HMM: 19-297/298.0
ANCHTDNNTLFGEQYKAIYNGED----KSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFW
|  .. . | . .... . ....    ... .. ..|||  ||. .| ..|  |.||.     .. ...| |||....|..|. |||.|.|...|..|||
avkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFW

RLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNStgDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQ
|....|.  .|||.|||.|  | |...|||..   ....| .||.| ..... |...|.|.|. .. . ..... | | |||||.||| .|| .. | ..
rmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrk

VMAtWSPSKG--PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEI
| | .    |  |..|.|||||||.|||||||  ||..|.| |||.  .|..||..|...||| .||||...|||| . ....||
vra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1023-1360 2.7e-83 274.8 In-house 14-348 (515) alignment 
Range on Protein: 1023-1360
Range on HMM: 14-348/515.0
TDNNTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKP
  . ||| |... .   .     .   . |   ||..|| ||| .|. |      |. .  | ||||| .. |   .|||||| | .. |||||..||..
nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenv

VSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVkiYNGSNdSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPS
  |.|||.|||| |.|| .|||.  ||  .|| . | |.  .   . ..|.|.|    |.. |.|.||.|.| |||.|||  .. |. | |.| |  .  
ttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqy

KGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMKLRELKEIDSSTGCSGLQ
. |...|||||||||| .|.||  . .||   .||.  .|. .||.|...||| .|| |...|||| ..  .| ||   .  .|..|.      | | . 
thpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmt

SQFELLSQVTPDPDDVFCDSAKAH--SDKNRSTSYLPQEN
 .|. |  ..|||    . |....    |||  . || . 
kefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqr
DSPc_SM00195 1032-1290 5.8e-82 270.3 In-house 5-262 (263) alignment 
Range on Protein: 1032-1290
Range on HMM: 5-262/263.0
QYKAIYNGE-DKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLdkCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTN
... . . . .|.|  .  ..||  ||..|| |||..|. |.. ..    ...| ||.||.|.... |.|| |||.. |. ||||..|.||   |||.|.
efekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYP-DFVIRQLNVKIYNGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVH
 .|  | ||..|||.. |..  || ..|.|.... .. ....|.|...  .  ......|||. ..|||||||| ......| ..|  . | |.|||.||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
|||||||||||..|||.|.. ..|  |||  ||..||.||..|||||.|| |...|.|| .
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1032-1290 5.8e-82 270.3 In-house 5-262 (263) alignment 
Range on Protein: 1032-1290
Range on HMM: 5-262/263.0
QYKAIYNGE-DKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLdkCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTN
... . . . .|.|  .  ..||  ||..|| |||..|. |.. ..    ...| ||.||.|.... |.|| |||.. |. ||||..|.||   |||.|.
efekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

LKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYP-DFVIRQLNVKIYNGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVH
 .|  | ||..|||.. |..  || ..|.|.... .. ....|.|...  .  ......|||. ..|||||||| ......| ..|  . | |.|||.||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
|||||||||||..|||.|.. ..|  |||  ||..||.||..|||||.|| |...|.|| .
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
Y_phosphatase Protein-tyrosine phosphatase 1052-1288 5.2e-80 263.6 Pfam-A 1-235 (235) alignment 
Range on Protein: 1052-1288
Range on HMM: 1-235/235.0
NKVYNRFRNITPYDDNRIVLtpwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDND
||  ||...|.|||..|. |    . .. .. | ||.|..||..  ||||.|||.| |. ||||..||||  .|||.|.|.|  . ||.||||.....  
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

HFGPFTVTLI-NEQ-VYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQ
..| ..|.|  .|.    ....|.|..|  ..........|.|.|.|||||||. ...|..| ..|  . ....||..|||||||||||||.|.||.|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
...|. ||.  ||..||.||..|||.|.||.||..|.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1052-1288 5.2e-80 263.6 In-house 1-235 (235) alignment 
Range on Protein: 1052-1288
Range on HMM: 1-235/235.0
NKVYNRFRNITPYDDNRIVLtpwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDND
||  ||...|.|||..|. |    . .. .. | ||.|..||..  ||||.|||.| |. ||||..||||  .|||.|.|.|  . ||.||||.....  
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

HFGPFTVTLI-NEQ-VYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQ
..| ..|.|  .|.    ....|.|..|  ..........|.|.|.|||||||. ...|..| ..|  . ....||..|||||||||||||.|.||.|||
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
...|. ||.  ||..||.||..|||.|.||.||..|.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1024-1326 2.9e-79 261.2 In-house 16-313 (315) alignment 
Range on Protein: 1024-1326
Range on HMM: 16-313/315.0
DNNTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWpqLDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPV
 . .|| |... . . .   . ..  ..|   ||..|| |.| .|..|      |. .  | ||||| .. .   .|||||| | .. ||||...|||. 
rhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevi..ddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvt

SIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLnvkIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSK
.|||||...|| | || ||||.  .|  .|| . |.|.. .   | |.|.|   .   |..|.|.||...| |||.||.  .. |. | |.| |   . .
tivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkke

GPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMKLRELKEIDSSTGCSGLQS
 ..|||||||||||| .|.||  ..|.||. .||.  .|. ||..|...||| ..| |..||||| ..  .| |.   .  .|..|.   . .| | .  
fsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtk

QFE
.||
efe
0050432 (Phosphotyrosine protein) phosphatases II 1290-1581 2.5e-77 255.6 In-house 12-305 (308) alignment 
Range on Protein: 1290-1581
Range on HMM: 12-305/308.0
VMCGDTEIPSNEYEMKLRELKE-IDSSTGCSGLQSQFELLSQVTPdPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKENNGYINASYLSGY--REKKAF
....||.|. . ... . .| . ... .. ..|. .|| | .|.| . . .. . ... ||||....|| ..  | |.|...|||||| .||  . ...|
llfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkf

IIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDS---DVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQD
|..|.|..||  |||.|. ...|. ||||. |.|.| | |.||| ..   .....| .....   .....|. |.....  .|. |  | ... |.|| .
IatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdh

GVVREPRTVLQVIDDVIHRQqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINSTY
||  .|. .|. .. | ...   .|||.|||||. |.|.|... . . ||| ..|| ||||.. | .|. .||.|.|.|||  .|... ..|    |.
gvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
0040439 (Phosphotyrosine protein) phosphatases II 1046-1291 6.4e-77 253.8 In-house 5-247 (249) alignment 
Range on Protein: 1046-1291
Range on HMM: 5-247/249.0
IGFSQENKVYNRFRNITPYDDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPN
..  .||| .||...| ||| .|..|...|      . | ||||||||   ..||| |||.. |. ||||..|...  .|||.|.|.|  . ||.||||.
vallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

stGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYnGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAI
  |.   .| |||||....|..|...|.| .. . . ..|.| .... |.|||||||..  .|... ..|.   .. |..||.||||||||||||||||.
..ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM
...||| ..|. ||.  .|. ||.||...||...||.||..|.|| ..
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1049-1292 4e-76 250.5 In-house 6-244 (250) alignment 
Range on Protein: 1049-1292
Range on HMM: 6-244/250.0
SQENKVYNRFRNITPYDDNRIVLTPWPqLDKcQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSkCEQYWPNStg
  .||  ||. .| ..|  |.|| .    || .. | |||...||..|  |||.|||...|..||||....||  .|||.|||||  |  ..||||    
kpqnkeknryadiialdssrvvLekek.gdk.esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..

DNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIAL
  ...|  ||.| ..... |...|.| .  .. . |. .. |.| ..||| |||..||  . | |.| |.     ..|..|.|||||||.|.|||||  |
kaekyGdvtvsllskeefadytkrklklskakka.derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

EQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMC
|..|.| |||.  ....||..|...|..|.||||.. ..|. . .
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1015-1291 1.1e-75 249.3 In-house 3-277 (281) alignment 
Range on Protein: 1015-1291
Range on HMM: 3-277/281.0
GTHVANCHTDNNTLFGEQYKAIYN-GEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDF
 .|... ....|. | |.|..... | |....  ...||.. ||..||. ||  |...||    .. .| | ||....||.. ...||.|||.  .||.|
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpne..enkntDYinanfvpgykgekeyiatqgPvPaslvaf

WRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTgDNDHFGPFTVTLINEQVYPDFVIRQLNVkiYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHK
|...|..|   |||||.  |. | || .|||. .  . ..| .||. ..|.  . .. |....  .. |... ...| . |.|||||||. .. |.. .|
WqmvweqkvsaivmvtreieagklkChrYWPddn.selkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrk

QVMATWSPS-KGPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM
.|. . ... | |...|||||||||||.||.| .......|   .|.  .|. ||..|. ||||. || |.. |||....
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0045098 (Phosphotyrosine protein) phosphatases II 1044-1294 1.2e-75 249.8 In-house 25-276 (278) alignment 
Range on Protein: 1044-1294
Range on HMM: 25-276/278.0
TVIGFSQENKVYNRFRNITPYDDNRIVltpwpqldkcqtTYTNASYIDGYsnRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
   .   .|.  ||...| ||| .|..             | ||||||||  ..|||| |||.. |. ||||..|...  .|||.|.|.|... ||.|||
itpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PNstGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIY---NGSNDSHTLTQYHLTSWPDHGVPDYA--TPLMSLHKQVMATWS-------------PSKGP
|.  |.   .|.|||||..|.|..|...| |.|        .. |...|..|...|||||||..   ... .| ... .  .             .|.||
pe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ILVHCSAGVGRTGTFIAIDIALEQAkrEGVVDIGGIVNRLRQQRMK-MVQTLDQYVFLHDAVLETVMCGD
.|||||||||||||..|... ||.   ||.||.  .|. ||.||.  .||.|.||.||....|| ...|.
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1009-1326 1.3e-75 249.5 In-house 5-324 (325) alignment 
Range on Protein: 1009-1326
Range on HMM: 5-324/325.0
IALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPwpQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKR
||. .|  || . .....  |  ... . . . ..  .    |||  |||.|. ..| .|.||    . |. .. | ||||.  . ..  |.|.| |.  
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvlet..kkddpssdyinasylrddkkkdvflaaqaPlta

TLVDFWRLI--WQekpVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSnDSHTLTQYHLTSWPDHGVPDYAT
|. |.|||.  |.    |.|.|.|  .. | .| .|||.  |.  .||.. | |.  . . |.| |.|.||  ..  .. .. |..| ||.| ||. . .
tindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpa

PLMSLHKQVM------ATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSN
 |.|. . |        . . . .||||||||||||||.||..  ||..   |  ||| | |..||..| .||.| |||.....|. |..|.|.|..| .
tlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvs

EYEMKLRELKEIDSSTGCSGLQSQFE
 .| ||  |.| .  |    .. .||
sfeaklsslqernpltqklniekefe
subfamily_PTPN12_pd Subfamily PTPN12 1042-1290 3.3e-75 247.7 In-house 30-277 (290) alignment 
Range on Protein: 1042-1290
Range on HMM: 30-277/290.0
KSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQ
 ||  | ..||.  ||...| ||| .|..|.   . .  .  | ||..| | ......||.|||. .|| ||||.||. .   .||. .. |  | |||.
ysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPNSTGDNDHFGPFTVTLINEQVYP-DFVIRQLNVKIYngsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTF
|||...... .||.|.|||..|.    ||.||.|.|.     ..|....|.| |.|||||||  |..|..| ..|  . . .. |..|||||||||||| 
YWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGti

IAIDIALEQAKREGV---VDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
||||.. |. |.| .   .|.  .| .||.||  .||| .||.... ||.| |
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0042113 (Phosphotyrosine protein) phosphatases II 1049-1288 1.5e-74 245.8 In-house 6-241 (245) alignment 
Range on Protein: 1049-1288
Range on HMM: 6-241/245.0
SQENKVYNRFRNITPYDDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNstG
 .||| .||...| |||..|..|.| .      ..| ||||.|||    ||||.|||.. |. ||||..|...  .|||.|.. |  . ||.||||.  |
lpenkdknrysdilpydhtrvklspdgg..dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

DNDHFGPFTVTLINEQVYPDFVIRQLNVKIyNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWS-PSKGPILVHCSAGVGRTGTFIAIDIAL
.   .| |||||..|....|...|.|.|.  .|.. |.. ..|| ..||||||||.   | .... |    . .|.||.||||||||||||||||....|
esltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

EQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
||...|. |..  .| .||.||...|||..||.||..|.||
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0051299 (Phosphotyrosine protein) phosphatases II 1294-1574 2.3e-74 245.7 In-house 2-285 (288) alignment 
Range on Protein: 1294-1574
Range on HMM: 2-285/288.0
DTEIPSNEYEMKLRELKeidsSTGCSGLQSQFELLSQVTPDpDDVFCDSAKAHSDKNRSTSYLPQENFLVTLK-----ENNGYINASYLSGYREKKAFII
||||. .|..  ...|.     .| .||. .|| | ...||  .. . . ... .|||....|| ..  | |.     |...||||||..||. |..||.
dteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

AQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSD----KDESSWDVIQLQVTDWPQDG
.| |..||  |||.|. ...|. ||||..|.|.| | |.||| .......|.....    .....|. |.....      .|. |  |.....|.|| .|
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

VVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKF
|   |. .|. . .|.. ..  ||||||||||. |.|.|... . . ||| ..||.|||... | .|. .||.|.|.|||  .|...  .
vpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1020-1297 6.5e-74 243.3 In-house 2-273 (283) alignment 
Range on Protein: 1020-1297
Range on HMM: 2-273/283.0
NCHTDNNTLFGEQYKAIYNgEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQldkcqtTYTNASYID---GYSNRTKFIASQGPMKRTLVDFWRL
| ...|| || |..| .    |....|  ..||| .||...| |.| .|. | . ..      .| ||..|     | .  |.|..|.|..|| ||||..
nlrvnnnklfrevlkrlsv.pdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkm

IWQEKPVSIVMVTNLKEGTKSKCEQYWPNStGDNDhFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVM
...|| ..|||.|.|.|. . || ||||.  |  | .|.||||| .|     |.|..| ..  . ....  |. | .  | . |       |. . | . 
vfdekitaivmltklqedlrikCsqyWPkr.Gsed.yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvis

ATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEI
      ||||.||||.|.|||..|||.  ....|. | |||.  .|. .|.||| .||||||| ..|..|||  .||||.|
lqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqi
0037934 (Phosphotyrosine protein) phosphatases II 1046-1288 7.9e-73 240.3 In-house 4-240 (243) alignment 
Range on Protein: 1046-1288
Range on HMM: 4-240/243.0
IGFSQENKVYNRFRNITPYDDNRIVLtpwpqlDKcqTTYTNASYIDGYSnrtKFIASQGPMKRTLVD----FWRLIWQEKPVSIVMVTNLKEGTKSKCEQ
|. ..||.  ||...| |||..|..|      .   . | ||..|...    ..||.|||.. |. |    |||..|...  .|||.|.|.| .. ||.|
iallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPnstGDNdHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--------WSPSKGPILVHCSAG
|||   |.  ..|.|||||..|....|...| | .. .. .. ... ..|| ..||||||||  ..|......| .           .|.||.|||||||
ywp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTFIAIDIALEQAkreGvVDIGGIVNRLRQQRMK-MVQTLDQYVFLHDAVLE
||||||.||... |..    | ||.  .|..||.||.  .|||..||.||..|.||
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1293-1582 1.5e-72 239.4 In-house 1-297 (298) alignment 
Range on Protein: 1293-1582
Range on HMM: 1-297/298.0
GDTEIPSNEYEMKLRELKEIDSSTGCSGLQSQFELLSQVTP--DPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKE-----NNGYINASYLSGYREKKA
|.||| .......|..|.... ... .|....|. |..|.   . .     ....  .||| ..... .   | |..     .  |||||.|..|....|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGV
||..| |...|  |||.|........||||  ||| ..  . .|| |.   ..||  ...  ..|   .| ||... . | |..  | ||..| ||. ||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

VREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINSTYA
 .. ..||.....|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| |..|...||||.| |||. ||... ..|.  ....
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0046845 (Phosphotyrosine protein) phosphatases II 1320-1582 6.2e-72 237.7 In-house 1-281 (284) alignment 
Range on Protein: 1320-1582
Range on HMM: 1-281/284.0
GLQSQFELLSQVTPDPD-DVFCDSAKAHSDKNRSTSYLPQENFLVTLK------ENNGYINASYLSGY-----REKKAFIIAQSPMENTARDFWKMIVDY
||. .|| | ..|...  .. .  .... .|||....|| ..  | ||      |...||||||..||     . ||.||..| |..||  |||.|. ..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KVSAIVMLCGLEEDGEESCYQYWRDSD-VVQFGEYFIKVEFSKECNGYIERKFHIRSDK-DESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK
.|. ||||..|.|.| | |.||| ... |...|......   .....|. |.. ..  . .. |  |.....|.|| .||  .|. .|. ...| . ...
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINSTYA
  ||||.|||||. |.|.|... . . ||| ..||   .|||... | .|. .||.|.|||||  .|...  .|    |..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1023-1309 1.6e-71 236.3 In-house 30-310 (319) alignment 
Range on Protein: 1023-1309
Range on HMM: 30-310/319.0
TDNNTLFGEQYKAIYNGEDKSTVIGFS--QENKVYNRFRNITPYDDNRIVLTPWPQLDkcQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQE
 |. | .  ..... .   . .   |.  ..||  ||. || ..| |.. | .    .   . | |||...|| .. |.||.|||.. || ||||.||. 
dddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGee..fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwey

KPVSIVMVTnlkegtKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYpdFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--
.  .||..|      | || ||||. .  ..  .   |....|     .|.|....      .|   .||.|.  |||.|||||...|| | |.|     
ncstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlts

WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMKLREL
    . .|.|||||||||||..|..|. |.. |.|  ||.  .|. ||||| ..|| | || |.. |.||  . | ...   ..   |.||
kenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel
subfamily_PTPN6_pd Subfamily PTPN6 1041-1288 1.8e-71 235.7 In-house 43-295 (306) alignment 
Range on Protein: 1041-1288
Range on HMM: 43-295/306.0
DKSTVIGFSQENKVYNRFRNITPYDDNRIVLTpwpQLDKCQTTYTNASYIDGYS--NRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSK
  |   |  .|||  ||..|| |.|..|..|.   . .  ...| ||.||.. .  .....||.|| .. |. ||||..|||.   |||.|.  | .|.|
llsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkek

CEQYWPNSTGDNDhFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSK----GPILVHCSAGV
| .|||... ... .|  .|| ..|.   |...|.|.|.  . ....... ||| .||||||||     .... ..| .  . ..    |||.||||||.
CarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGi

GRTGTFIAIDIALEQAKREGV---VDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
||||||| ||| |.. ...|.   .||  .|. .|.||  .||| .|| |.. |. .
GRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
0036941 (Phosphotyrosine protein) phosphatases II 1309-1578 3.6e-71 235.2 In-house 3-280 (297) alignment 
Range on Protein: 1309-1578
Range on HMM: 3-280/297.0
LKEIDSSTGCSGLQSQFELLSQVTPdPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLkENNG--YINASYLSGYREKKAFIIAQSPMENTARDFWKMIVD
|| ...... ..|...|| | .. . . .  . . ... .|||....|| ..  | | ...|  ||||||..||. |..||..| |..||  |||.|. .
lkllekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

YKVSAIVMLCGLEEDGEESCYQYWRDS--DVVQFGEYFIKVEFSKE--CNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHR
..|. ||||. |.|.| | |.||| .   .....|......   ..  ...|. |....   ... |  | ....|.|| .||   |...|. |. | ..
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

QQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCK---AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAIN
.... .||||.||||. |.|||... . . |.| .    || ||.... | .|. .||||.|||||  .|... ..|  .
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0047943 (Phosphotyrosine protein) phosphatases II 1310-1573 1e-70 233.7 In-house 3-270 (273) alignment 
Range on Protein: 1310-1573
Range on HMM: 3-270/273.0
KEIDSSTGCSGLQSQFELLSQVTPdPDDVFCDSAKAHSDKNRSTSYLPQENFLVTL-KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYK
. .....| ..|. .|||| ...| . .  . . ... ||||....|| ..  | |  ....||||||..||. |..||..| |..||  |||.|. ...
lllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

VSAIVMLCGLEEDGEESCYQYWRDSD---VVQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK
|. ||||. |.|.| | |.||| ..    ....|......   .....|. |.. ... ... |  |.....|.|| .||   .  .|. |..| . ...
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

I-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDK
. ..||||||||. |.|.|... . . |.| ..|| |||... | .|. .||.|.|.|||  .|... .
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 1319-1577 1.7e-70 233.1 In-house 18-278 (317) alignment 
Range on Protein: 1319-1577
Range on HMM: 18-278/317.0
SGLQSQFELLSQVTPDpdDVFCDSAKAHSDKNRSTSYLPQENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIV
 .|...|| | ....|  .  . . ... ||||....|| ..  | |.      ...|||||| .|...|..||..|.|..||  |||.|. ...|. ||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLCGLEEDGEESCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiG-GGPVV
||. |||.| | |.||| . .....|......   .|..|.. |....  ..|. |  | ... |.|| .||   |...|. .. | . ..  . ||||.
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvl

VHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAI
||||. |.|.|... . . |||.. || |||... | .|. .||||.|.|||  .||.. ..|  
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1050-1309 7.6e-70 230.6 In-house 23-274 (284) alignment 
Range on Protein: 1050-1309
Range on HMM: 23-274/284.0
QENKVYNRFRNITPYDDNRIVLTPWPQldKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTnlkegtKSKCEQYWPNSTGD
..||  ||. .| ..| |.. | .     .  . | |||.| || .. |.||.|||.. || ||||.||. .  .||..|      | || ||||. .  
dqnkdknrighilafdknvvklerliG..eefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

NDHFGPFTVTLINEQVYpdFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGVGRTGTFIAIDIAL
... .   |....|     .|.|....      .|  ...|.|.  |||.|||||...|| | |.|    .    . .|.|||||||||||..|..|. |
keerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvll

EQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMKLREL
.. |.|  ||.  .|. ||||| ..|| | || |.. |.||  . | ...   ..   |.||
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
subfamily_PTPN9_pd Subfamily PTPN9 1030-1289 4.4e-69 227.8 In-house 19-289 (297) alignment 
Range on Protein: 1030-1289
Range on HMM: 19-289/297.0
GEQYKAIYNGEDKSTVIGFS-QENKVYNRFRNITPYDDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMV
 ..|..| | . . |.  .  . |   ||. ..  ||. |.||.  .  .. .. | ||...||| ..  ||| |||.|.|  ||||..|... . |||.
skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvd..edeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt

TNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVM-----------A
| . |  . || ||||..... ..|| ..|. .. ... |...|.|..|  .  ..| ..| . ..||||.|||. |. |. . ..|            .
trvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgd

T--WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLET
.    ||. ||.||||||.|||||||..||.|.. ...|.||.   |..||.||  ..|| .||.| . |||| 
ewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
0039614 (Phosphotyrosine protein) phosphatases II 1309-1576 1.4e-68 226.9 In-house 22-290 (297) alignment 
Range on Protein: 1309-1576
Range on HMM: 22-290/297.0
LKEIDSSTGCSGLQSQFELLSQVTPDpddVFCDSAKAHSDKNRSTSYLPQENFLVTLKENNG------YINASYLSGYRE-KKAFIIAQSPMENTARDFW
|. ..  .....|. .|| | ...||     .   ... ||||....|| ..  | || ..|      ||||||..||.  ...||..| |...|  |||
llllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

KMIVDYKVSAIVMLCGLEEDGEeSCYQYWRDSDVvQFGEYFIKVEFSKECNGYIERKFHIRSdkDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIH
.|. ...|..||||. |.|.|   |.||| ..   ..|......   ....||. |.....   .. |  | ..|.|.|| .||   ....|.... | .
rmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvre

RQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLA
....  .||||.||||. |.|.|...   . |||.. || |||... | .|. .||||.|..||  .||.. ..| 
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0043336 (Phosphotyrosine protein) phosphatases II 1313-1571 4.5e-68 225.0 In-house 14-273 (278) alignment 
Range on Protein: 1313-1571
Range on HMM: 14-273/278.0
DSSTGCSGLQSQFELLSQVTPdpDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDY
   .....|. .|| | ....  |.  .   ... ||||....|| .. .| |.      ...||||||..||. ...||..| |...|  |||.|. ..
lllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel

KVSAIVMLCGLEEDGEESCYQYWRdSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkIG
.|. ||||..|.|.| . |.|||  ......|......   .....|. |....   .|  |  | ... ..|| .||   . ..|. . .|.....   
gvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.ds

GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.|||.||||. |.|.|... . . ||| . || ||.... | .|. .||||.|..||  .|...
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
DSPc_SM00195 1321-1575 6.3e-68 224.3 In-house 2-262 (263) alignment 
Range on Protein: 1321-1575
Range on HMM: 2-262/263.0
LQSQFELLSQVTPDPdDVFCDSAKAHSDKNRSTSYLPQENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVML
|. .|| | . |..  .. .   |. ..|||.. .|| ..  | ||..     . ||||.|..|...||..|..| |...| .|||.|... ||. ||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CGLEEDGEESCYQYWRDS--DVVQFGEYFIKVEFSKECN-GYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVV
.  ||.|.| |..|| ..  .  .||.. .|.   ....  .| |..... ...| . .| |.|...||. ||  ... ||...  | ......  ||.|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFL
||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..| ...
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1321-1575 6.3e-68 224.3 In-house 2-262 (263) alignment 
Range on Protein: 1321-1575
Range on HMM: 2-262/263.0
LQSQFELLSQVTPDPdDVFCDSAKAHSDKNRSTSYLPQENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVML
|. .|| | . |..  .. .   |. ..|||.. .|| ..  | ||..     . ||||.|..|...||..|..| |...| .|||.|... ||. ||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CGLEEDGEESCYQYWRDS--DVVQFGEYFIKVEFSKECN-GYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVV
.  ||.|.| |..|| ..  .  .||.. .|.   ....  .| |..... ...| . .| |.|...||. ||  ... ||...  | ......  ||.|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFL
||||. |.|.|......| |.....|  ||.|.. |..| ..||.|.|||||. ||..| ...
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1008-1302 5.3e-67 221.0 In-house 9-296 (297) alignment 
Range on Protein: 1008-1302
Range on HMM: 9-296/297.0
PIALEDLGTHVANCHtdNNTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPqlDKCQTTYTNASYIDGysNRTKFIASQGPMK
|| | |. | | . .  . ..| |... . . . ...     . |   .|..|| ||| .|. |      |. .  | |||.. |  |. ..|..| |||
piplsdfatlvqknr..htdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkg..nkhrlittqmPmk

RTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNSTGDNdhFGPFTVTLINEQVYPDFVIRQLNVKIyNGSNDSHTLTQYHLTSWPDHGVPD--YA
 |. |||.....|..  |||.....|..| || .||....  .  ||  .|.|   .    |. |.|.|.  . .   . . ||. ..|||. |.    |
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsa

TPLMSLHKQVMATWSPSKG-PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEY
. |. | ..|  ..|  .  |.||||.||||||| ...||  . .||||  ||| |.|..|||.|...||| .|| |.. ||||.... ||.|... .
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1053-1287 8.2e-67 220.2 In-house 29-265 (274) alignment 
Range on Protein: 1053-1287
Range on HMM: 29-265/274.0
KVYNRFRNITPYDDNRIVLTPWpQLDKCQTTYTNASYIDGYSNRTK-FIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGD--
.  ||...| | .  |..|..  . .. ...| || || ||....| ..| |||.  |. ||||.|.||.   |||.|.|||  ..||..|.|....   
qtknryktilPnensrvllese.ssededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

NDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGsndSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPS---KGPILVHCSAGVGRTGTFIAIDIA
....| . ..  .     |. .|.| .|  .    ..... |  |.|||| .|| |..|..| ..|  . . .    .|..||||||.|||| ||||.||
serygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVL
. | ..|.|||. .||  ||..|  |||| .|| ..| |. 
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
0045450 (Phosphotyrosine protein) phosphatases II 1308-1573 8.7e-67 221.3 In-house 16-302 (307) alignment 
Range on Protein: 1308-1573
Range on HMM: 16-302/307.0
ELKEIDSSTGCSGLQSQFELLSQVTPD-PDDVFCDSAKAHSDKNRSTSYLPQENFLVTLK------ENNGYINASYL--------SGYREKKAFIIAQSP
 |. ..  .. .||. .|| | .||.. ...  . . ... ||||....|| ..  | |.      |...||||||         .||. |..||..|.|
llvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

MENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDS-DVVQFGEYFIKVEFSKECNGYIERKFHIRSD-KDESSWDVIQLQVTDWPQDGVVREPR
...|  |||.|. ...|..||||..|.|.| | |.||| |. .....|......   ....||. |....    ... |  |.... |.|| .||   . 
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfe

TVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDK
..|. |. | . ...  .||||.||||. |.|.|...   . |.| ..||.   ||.... | .|. .||||...|||  .|... .
elldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 1347-1571 2e-66 219.2 Pfam-A 2-233 (235) alignment 
Range on Protein: 1347-1571
Range on HMM: 2-233/235.0
SDKNRSTSYLPQENFLVTL---KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWR--DSDVVQFGEY
..|||....|| ..  | |   .... ||||.|..||.|||.||..| |...|  |||.|....||..||||. ||| |.| | |||   ... ...|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

FIKVE-FSK-ECNGYIERKFHIRSDKDES-SWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE
.....  .| ....|. ||......|.|| .  | ||..|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. |||.|. | .|...||.|..||||  .|..|
eevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1347-1571 2e-66 219.2 In-house 2-233 (235) alignment 
Range on Protein: 1347-1571
Range on HMM: 2-233/235.0
SDKNRSTSYLPQENFLVTL---KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWR--DSDVVQFGEY
..|||....|| ..  | |   .... ||||.|..||.|||.||..| |...|  |||.|....||..||||. ||| |.| | |||   ... ...|..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

FIKVE-FSK-ECNGYIERKFHIRSDKDES-SWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE
.....  .| ....|. ||......|.|| .  | ||..|.||. || ..|. .|..|..| ... .   ||||||||. |.|.|......| |||..||
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
. |||.|. | .|...||.|..||||  .|..|
eevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPRD_pd Subfamily PTPRD 1366-1582 2.3e-66 219.6 In-house 73-288 (564) alignment 
Range on Protein: 1366-1582
Range on HMM: 73-288/564.0
KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDK
.|.  |||||.. |||..||.| .| |...| .|||.|. ....| ||||  ||| |.. | .|| ...  ..||. ...| ..| . |. |.| ..  |
degsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk

DESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYT
...|  | | . |.||. ||  .....|..|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. ||.|. ..  | | ||| 
ssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYi

SIYDVIDKFLAINSTYA
 |...| ..||  .|  
Fiheailealacgntev
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1013-1303 2.3e-64 212.5 In-house 6-292 (439) alignment 
Range on Protein: 1013-1303
Range on HMM: 6-292/439.0
DLGTHVANCHTDNNTLFGEQYKAIYNGEDK--STVIGFSQE-NKVYNRFRNITPYDDNRIVLTPWPQLDKcqTTYTNASYIDGYSNRTKFIASQGPMKRT
..  || . . ... .| | .. |   . .        .|| ..  ||.......|  |..|   | . .  . | || ||.|| .   .||.||| | |
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvph..shyinanyikGyyddklyiatqgpkket

LVDFWRLIWQEKPVSIVMVTNLKEGTKskceqYWPNStgDNDHFGPFTVTLINEQVYPDFVIRQLNVKI-YNGSNDSHTLTQYHLTSWPDHGVPDYATPL
  |||||....| | |||.||| |  |     ||| .  ..  .|  .|    .   |..||| ..|    . ..  .|. |.| ..|||. ||  |. .
tddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashv

MSLHKQV-MATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYE
. . . .  |  .   ||..|||||||||||| ||.|||||| | |  ||| |||. ||.|| .|||.| ||||...|||| .. ||. .  .|..
ldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefk
subfamily_PTPN3_pd Subfamily PTPN3 1032-1290 2.9e-64 211.7 In-house 20-275 (280) alignment 
Range on Protein: 1032-1290
Range on HMM: 20-275/280.0
QYKAIYNGEDK-STVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQlDKCQTTYTNASyIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTN
|.. .|  . . .. .    || . ||.|.|.|||. |. |.  .. |   . | |   |.. .  ...||.|||...|  |||...|..|   |||.|.
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnme.ipstglvnryiatqGPlaktatdfWqmvweqksslivmltt

LKEGTKSKCEQYWPNsTGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHC
| |  . || ||||. |.|. ..| |.|.. .|.    .|.|.| .|  . ........|   ..|||||||| .. .... ..| .. | .. |..|||
lverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

SAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
|||.|||| .|....||    ..  | .  || ..|.||. .||| .|| |. .|.|.  
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_PTPN13_pd Subfamily PTPN13 1043-1289 2.9e-64 212.0 In-house 28-268 (273) alignment 
Range on Protein: 1043-1289
Range on HMM: 28-268/273.0
STVIGFSQENKVYNRFRNITPYDDNRIVLTpwpqlDKCQttYTNASYIDGY--SNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCE
.. .| ..|||  ||.||. |||. |. |      |.    | |||.|      .. ..||.|||.  |  |||...|. |   |.|||. ||. | ||.
tcevgkkkenkdknryrnvlPydetrvklg.....degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

QYWPNSTGDNDHFGP-FTVTLINEQVYPDFVIRQLNVKIyNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQvMATWSPSKGPILVHCSAGVGRTGT
.|||.|....      ..|.|.. | . .||.|.|.||  . |..|. ... ....|||||||  |..|. . .. ...   ..|||.||||||.||.||
rywPesknkklkvsnrlevellkvqkldgfvvralavkd.sesgesrevahlnfvkwPdhgvPssaaellqfvae.vrrlqtdagPivvhcsaGiGrsGt

FIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLET
.|.||..|.  .|.  .|.  ||..||.||  .||| |||.| . |.|| 
litidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1034-1288 3.6e-64 211.4 In-house 2-262 (270) alignment 
Range on Protein: 1034-1288
Range on HMM: 2-262/270.0
KAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQldKCQTTYTNASYIDGYSN-RTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLK
| . ..| ... .     .|..||...| |    |..| .  .  . .|.| || |. |... ..|.||..||.. || .|||.||.||  .|||.|.|.
keldkeetsesdlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgle

EGTKSKCEQYWPNSTGD--NDHFGPFTVTLINEQVYPDFVIRQLNVKiYNGSndSHTLTQYHLTSWPDHGVPDYAT------PLMSLHKQVMATWSP-SK
|  ..|||.|||.....  . ..|  .|. ..|.    .....|... ..|.  .. |. .. ..|||||||  .        |... ..| .. .  .|
EkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldk

-GPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
 .|.|||||||||||||.||.|||..  .... ||.  |...||..||..||. .|| ||. ||.|
aePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1324-1580 4.1e-64 211.6 In-house 28-288 (319) alignment 
Range on Protein: 1324-1580
Range on HMM: 28-288/319.0
QFELLSQvtPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGL
.|.||..  ...|..   | .  ..||| .  |. ..  |.|.|     .  |||||.. ||.|...|| .|.|.|||  |||.|. ....| .|||..|
efkllke..avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltkl

EEDGEESCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDES-SWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSD
 | ..  . .|| . .....|.. ...|  .| ..|| ||....  ..|  . .| . | |.||...| .. ...|... .. . ..|   ||.|||||.
veklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsa

TVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINST
 | | | .. ... ||. | |||.|||.. . .|  ..  | . |||. ||... ... . .|
GvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
0040439 (Phosphotyrosine protein) phosphatases II 1337-1571 8.9e-64 210.8 In-house 2-242 (249) alignment 
Range on Protein: 1337-1571
Range on HMM: 2-242/249.0
DVFCDSAKAHSDKNRSTSYLPQENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWR
.. . . ... ||||....|| ..  | |.       ..||||||..||. |..||..| |...|  |||.|. ......||||. |.| | | |.||| 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSI
.......|......   .....|. |....   .| .|  | ..|.|||| .||   . ..|. |. | . ....  ||||.||||. |.|.|...   .
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

GLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 ||| . |. ||.... | .|. .||||...|||  .|...
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1051-1288 6e-63 207.2 In-house 6-238 (239) alignment 
Range on Protein: 1051-1288
Range on HMM: 6-238/239.0
ENKVYNRFRNITPYDDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTK-FIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGd
 ||  ||. ||  || .|.||      .  .. | ||||.  |    | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.||  
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

ndHFGPFTVTLINEQVYPDFVIRQLnVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQ
  ..  . ||| . .|. |..|| . |    |  . . . |||.| |||.|||.||| .. |....     |   | ..||||||||||.|. ||  | |
..kycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
||..  |||   |. .|..| .|||| .||||.| ||||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1345-1582 6e-63 207.4 In-house 8-249 (250) alignment 
Range on Protein: 1345-1582
Range on HMM: 8-249/250.0
AHSDKNRSTSYLPQENFLVTLKENN-----GYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEEsCYQYWRDSDVVQFG
.  .||| . ... ..  | |....      |||||.| ||.|.||||..|.|...|  |||.|....|...||||  |.| ... . |||      ..|
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

EYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEG
.  ...  ..|   |. ||. . . | ...  | ||. . ||  || .. ..||.....|   ||..| .||.|.||  |.||| .. ..  ||. | | 
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINSTYA
|||||.| |..|. .|.||..|||| ..| .| |.|   . ||
vvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1051-1288 1.1e-62 206.3 In-house 7-239 (239) alignment 
Range on Protein: 1051-1288
Range on HMM: 7-239/239.0
ENKVYNRFRNITPYDDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTK-FIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGd
 ||  ||. ||  || .|.||      .  .. | ||||.  |    | .||.|| .. .  ||||..|||. . |||.| | || | || ||||.||  
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

ndHFGPFTVTLINEQVYPDFVIRQLnVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQ
  ..  . ||| . .|. |..|| . |    |  . . . |||.| |||.|||.||| .. |....     |   | ..||||||||||.|. ||  | |
..kycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

AKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
||..  |||   |. .|..| .|||| .||||.| ||||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1051-1288 4.2e-62 204.5 In-house 2-237 (237) alignment 
Range on Protein: 1051-1288
Range on HMM: 2-237/237.0
ENKVYNRFRNITPYDDNRIVLTPWPQLdkcqTTYTNASYIDGYSNR-TKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPnSTGD
|||. ||. ||. || .|.||          . | ||.|..|.     |.||.|||.. .  |||...||||   |||.| | || . || .||| || .
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdq

NDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT--WSPSKGPILVHCSAGVGRTGTFIAIDIAL
   .| .||.|  .. . |. .| | .      ..   . ||..|||||.|||.... |. . |...      .  || ..|||||||||| |. ||  |
paaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

EQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
 ||| . ||||   |  . ..|  ..|| |||||.|...||
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1342-1583 2.1e-61 202.7 In-house 42-288 (318) alignment 
Range on Protein: 1342-1583
Range on HMM: 42-288/318.0
SAKAHSDKNRSTSYLPQENFLVTLKENN-----GYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVV
  ..   ||| .  |. ..  | |.. .      ||||.|. |||.|||.| ||.|. .| .|||.|. . . . ||||  .|| | . . .|| ...  
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsr

QFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK
..|.  .... ..|.. |. |.|... .. |.| .| | ..|.||. ||  .. ..|... .| . ||| | ||.|||||  | | ||.. |.| ||. |
sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerik

AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINSTYAN
||..|||||. | .|. ..  | | .||. ||||. ..||   |...
aealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
0042113 (Phosphotyrosine protein) phosphatases II 1342-1571 6.8e-61 201.1 In-house 5-239 (245) alignment 
Range on Protein: 1342-1571
Range on HMM: 5-239/245.0
SAKAHSDKNRSTSYLPQENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVV
. ... ||||....|| .. .| |.. .|     |||||| .||| .. ||..| |...|  |||.|. ......||||. .||.| . |.||| .....
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

QFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK
..|......   . ...|. |....  ..|  |  ||... ..|| .||   ....|.... | . ... ..|||.||||. |.|.|... . . ||| .
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqle

AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
.|. |..... | .|. .||||.|..||  .|...
kelgvsleeavkelrsqRpgavqtpsqyrflyeal
0045098 (Phosphotyrosine protein) phosphatases II 1326-1575 1.4e-60 200.4 In-house 13-272 (278) alignment 
Range on Protein: 1326-1575
Range on HMM: 13-272/278.0
ELLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTlkennGYINASYLSGYreKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEES
     ....|.....     . |||| ...|| ..  |      .||||||..||  .|.||..| |...|. |||.|. ......||||..|.|.| | 
fefllllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

CYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSD----KDESSWDVIQLQVTDWPQDGVVREP--RTVLQVIDDVIHRQQK------------IG
|.||| .......|.......  .... |. |.....      .|  |. | .|. . ||  ||  .|  . .|.... . .....             .
caqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

GGPVVVHCSDTVSRSGVYCSVSIGLEQCkaEGVVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVIDKFL
||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..||||  .|... ..|
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN23_pd Subfamily PTPN23 1020-1290 2.7e-60 198.6 In-house 8-280 (288) alignment 
Range on Protein: 1020-1290
Range on HMM: 8-280/288.0
NCHTDNNTLFGEQYKAIYNGEDK---STVIGFSQENKVYNRFRNITPYDDNRIVLTpwpqldKCQTTYTNASYIDGYSNR-TKFIASQGPMKRTLVDFWR
.   |..| .....| . . .||   .. |  .. .   ||.|.| ||| ||..|       . .  | |||.. . |    .|||.|.|.. || |||.
rkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWl

LIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYnGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV
.....|   |||... .|  | |...|||...|.  .||...||| ...  . .| |.|....  ...  ....  .|||||..|||.    |. . ..|
mvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletl.dadavksvshlqltsWpelGvPasPetllqfldev

MA----TWSPSKGPILVHCSAGVGRTGTFIAIDIAL-EQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
 .    .  .|| |..|||||||||||.|  .  |. |  |..|..||  .|.|||.||  |||. .|. |. .||||..
esayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPRA_pd Subfamily PTPRA 1345-1575 1.7e-59 196.4 In-house 57-295 (330) alignment 
Range on Protein: 1345-1575
Range on HMM: 57-295/330.0
AHSDKNRSTSYLPQENFLVTLKEN-----NGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVVQFG
   .|||    || .   | | .        |||||.. ||.||. || || | |.|  |||.|| ..| ..||||  |.|  || |.||| |  .| .|
enkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyG

EYFIKVEFSKECNGYIERKFHIR----SDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIGLEQC
.  ..|| ..... |  ||| ..    . ....|  | |.  | ||. ||  ||. .|...  | . .|. .| |.|||||  | |.| .. ..  ||. 
nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlerv

KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFL
|||..||||.. | .|  .|  | |.|||. || |. .. 
kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1025-1311 3.7e-57 188.5 In-house 18-257 (392) alignment 
Range on Protein: 1025-1311
Range on HMM: 18-257/392.0
NNTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVS
 ..|| |... . . .   . ..  . |.  ||..|| ||| .|..|      |  .. | |||||... |   .||||||   .| ||||...||.. .
hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid..dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvtt

IVMVTNLKEGTkskceqywpnstgdndhfgpftvtlineqvypdfvirqlnvkiynGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKG
|.|||.||||                                                .| .| .|.|.| |||..|| ... |. . |.| | .     
iamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth

PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEIPSNEYEMKLRELKE
|...||||||||||  |.||  . .||.  .||.  .|  .|..|  |||| .|| |.. |||| ..  .| ||   .  .|..|. 
pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlst
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1320-1572 3.8e-57 188.3 In-house 7-264 (283) alignment 
Range on Protein: 1320-1572
Range on HMM: 7-264/283.0
GLQSQFELLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKE-NNGYINASYLS---GYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVML
. . ..| | ...  . |. ..||. .  |||    .|.... | ||  .. ||||...     |...| .||||||...| .|||||. | |..|||||
nnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

CGLEEDGEESCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSD-KDESSWDVIQLQVTDWpqdgVVREPRTVLQV---IDDVIHRQQKIGGGPV
  | || .. | |||     ...||. . ..     | .| ... .| .   .|.  .   || ||    .  .. ...     .. ||  |..   ||.
tklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPi

VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI-D
||||| .. |..|....|  ... ..| |||||.| | .|  ...|| ||.||  ..... .
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Ptp69D_pd Subfamily Ptp69D 1320-1574 4.3e-57 188.6 In-house 23-285 (307) alignment 
Range on Protein: 1320-1574
Range on HMM: 23-285/307.0
GLQSQFELLSQVTPDPDDVFCDSaKAHSDKNRSTSYLPQENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVM
||.  .| | . . | . .. .  |    |||.    . ..  | ||.     .  |||||.. ||.||| ||.|| |.|.|. |||.|| . .|  |||
glakeyekLeareidkstkvsek.kenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

LCGLEEDGEESCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDES-----SWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGG
|  |.|  .. | .|| . | ||.|.  .|.  ..... ||.|....   |.||     |  |.| . | |.   | . .|..|..|. | . ...   .
lsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rs

PVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKF
|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. ||||. .|  . ..
PivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_CG7180_pd Subfamily CG7180 1045-1294 6.5e-56 184.1 In-house 35-294 (296) alignment 
Range on Protein: 1045-1294
Range on HMM: 35-294/296.0
VIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLDKCQttYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWP
  |  .||.  ||  .. ||| ||.||.     .| .  | ||.|.|..    ..|  ..|.|.|. .||||...|.  ..|..|.  . .| .. .|||
agglrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

NSTgdNDHFGPFTVTLINEQVYPDFVIRQLNVKIY---------NGSNDSHTLTQYHLTSWPD-HGVPDYATPLMSLHKQVMA---TW--SPSKGPILVH
| .  . ..|.. | ...|. |....||.. ..           . . .  ......|| |.  . ||  .. |. | ..|          | .||..|.
nks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGD
.| |..|.| ..|||..||....|. ||. . | .||..| ..|.. ..| .. | .|| |.|. 
ssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_PTPRG_pd Subfamily PTPRG 1317-1577 1e-55 184.1 In-house 17-289 (563) alignment 
Range on Protein: 1317-1577
Range on HMM: 17-289/563.0
GCSGLQSQFE-LLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKENNG------YINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKV
|  |.. .|| | |.....  |.   ...    ||| .. .. ..  |.|..  |      ||||.|. ||. .||||..| |...|. |||.|| . .|
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

SAIVMLCGLEEDGEESCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRS-----DKD-ESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDViHRQ
. |||.  |.|.| . | .||   .....|.  .. . ..    | .|.. |.       |. ..   |.| . |.||. ||   .  ||. .     . 
aiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saa

QKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAI
.|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |||. ..|.. . .| 
nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPRN_pd Subfamily PTPRN 1023-1290 5.8e-55 181.1 In-house 25-292 (297) alignment 
Range on Protein: 1023-1290
Range on HMM: 25-292/297.0
TDNNTLFGEQYKAI--YNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPwpQLDKCQTTYTNASYIDGYSNR-TKFIASQGPMKRTLVDFWRLIWQ
  |.. . ....|.  |. |.... .. ...|   || ... |||..|. |.   . .. .. | ||| |     | . .||.|||.  |. |||...|.
lknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklke..easaeksdyinasaildhdprapayiatqgplastvadfwqmvwe

EKPVSIVMVTNLKEGTKSKCEQYWPNSTGDndHFGPFTVTLINEQVYP-DFVIRQLNVKIYNgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAT
.  | ||..|.|.|   ..|..|||.   .   .. . | |. | ..  |...| . .|  . .... |.||.|  |||..|||  | .|. . ..|  .
qGvvvivnltrleeegvkqckrywpdeGse..vyhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvnks

WSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
.     ||.||||.|.||||..|.||. |.. ..    .||   .. ||.|| ..|.| ||. |   || | |
yrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_PTPN1_pd Subfamily PTPN1 1040-1297 1.2e-54 180.1 In-house 20-280 (290) alignment 
Range on Protein: 1040-1297
Range on HMM: 20-280/290.0
EDKSTVIGFSQENKVYNRFRNITPYDDNRIVLtpwpqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
.| .|     .||.  ||.|...|||  ||.|      .. .. | ||| ..    . ..| .|||. .|   ||...|..|  ..||. .. |  . ||
sdfptreaklpenrnlnryrdvspydhsrikl......eradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

EQYWPNSTG-DNDHFG--PFTVTLINEQVYPDFVIRQLNVKIYNgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMA--TWSPSKGPILVHCSAGV
 ||||.    ..  .    ..|.||.|...  ...|.|...  . ..........| |.||| |||.  . ....  .|    . |. .|| ..|||||.
aqywPqgeeekellledtklkvkliseerksyytvrllelenlk.tqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRTGTFIAIDIALEQAKRE---GVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV--MCGDTEI
||.|||. .|  | . ...     |||   .  ||..|. ..|| ||  | . |.|| .  . ||. .
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv
subfamily_PTPN14_pd Subfamily PTPN14 1026-1288 1.3e-54 180.3 In-house 23-294 (300) alignment 
Range on Protein: 1026-1288
Range on HMM: 23-294/300.0
NTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLdkcQTTYTNASYIDGY--SNRTKFIASQGPMKRTLVDFWRLIWQEKPV
  .| |  .   . ||  .  .  .||.  |||... ||.|||. |.|  .    .| | ||| |     ... ..|..|||.. |. |||...|...  
gkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

SIVMVTNLKEGTKSKCEQYWPNSTG--DNDHFGPFTVTLINEQVYPDFVIRQLNVKiYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSL-------HKQ
 |||.|. .|. | |. .|.|...   .. .|| | ||    .  . .. ..|..| .  |..  |.     | |||||||.  .. .|         ..
livmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklk.hlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

VMATWS--PSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
.  . .   || |.||||||||||||  |  |. ..  . . ..||  ...|||.||| .|||| || |.......
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
0037934 (Phosphotyrosine protein) phosphatases II 1342-1572 5.6e-54 178.6 In-house 6-239 (243) alignment 
Range on Protein: 1342-1572
Range on HMM: 6-239/243.0
SAKAHSDKNRSTSYLPQENFLVTLkENNGYINASYLSGYreKKaFIIAQSPMENTARD----FWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRdSDVvQ
. ... .||| ...|| ..  | | |...||||..  ..  .. .|. | |...|  |    ||.|. ......||||. |.| | | |.|||  ..| .
llpenlsknrysdilpydhsrvkl.egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.gev.t

FGEYFIKVEFSKECNGYIERKFHIRSDK-DESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQK-------IGGGPVVVHCSDTVSRSGVYCSVS
.|......  ......|. |.....  . |. .. ||... . ||  ||  .|  .|. .|.|.  ...        .||||.||||  |.|.|...   
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaay

IGLEQCkaeGvVDVFQVTKAVRRSKPG-AVTTLEQYTSIYDVID
. |...   | ||.... | .|. .|| ||.|..||  .|... 
lmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall
0051429 (Phosphotyrosine protein) phosphatases II 1083-1298 5.9e-54 178.8 In-house 5-232 (272) alignment 
Range on Protein: 1083-1298
Range on HMM: 5-232/272.0
TYTNASYIDGYSN---RTKFIASQGPMKRTLVDFWRLiWQEKPVSIVMVTNLKEGTKSKCEQYWP----------NSTGDNDHFGPFTVTLINEQVYPDF
.| ||....|| .   . ....|.||.. |  ||||| ....  .||..... |  . ||..|||          ...     .| ..|||. |....|.
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYAtpLMSLHKQVMAtwspsKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVD--------IGGI
..| | .... . .........| |.|||||||. |  | .| ... .     .||.|||||||..||||..|... |..  .| .||        . ..
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VNRLRQQRMKMVQTLDQYVFLHDAVLETvMCGDTEIP
|..||.||...||| .||.||..|.||  ... ....
veelraqrpgavqteeqylflyeallel.lrsllsvr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1346-1580 2.2e-53 176.4 In-house 51-289 (297) alignment 
Range on Protein: 1346-1580
Range on HMM: 51-289/297.0
HSDKNRSTSYLPQENFLVTLKEN-----NGYINASYLSGYREkkAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEeSCYQYWRDSDVVQFGE
  .|.| .  || .   |.|.         |.|||.. |...   .|  | ||..|  |||.|..|..||.||||  ..|  . .| .|| |. |..||.
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGd

YFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVR--EPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE
  ....  .|..|.|.|..... .|  .   | | | ..||.. | |  . ...|..|..| .  ..   ||..|||.  | | ||....   . . | |
vsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakre

GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINST
  ||.|.. | .|...|  | | |||. .| .. ..|  . |
kevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_PTPRK_pd Subfamily PTPRK 1345-1572 2.5e-53 176.0 In-house 42-274 (314) alignment 
Range on Protein: 1345-1572
Range on HMM: 42-274/314.0
AHSDKNRSTSYLPQENFLVTLK---E--NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVVqFG
 . .||||.  |. .. .|.|.   .  .. ||||... .|.  .|||..| |...| .|||... |.. ..||||  | | |   |..|| .   | .|
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.yg

EYFIKVEFSKECNGYIERKFHIRS--DKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKiGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.  ...  ..  . .. | | ..    . |    | |.| . ||. .|  . ...|...  | . |.. . |..|||||    |.|... ..| |.  . 
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmier

EGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
|||||||.. |..| .|.  | | |||. ||||| 
egvvdvfnavktlrsrkvnmveteeqykfiydvil
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1314-1572 1.2e-52 173.7 In-house 16-276 (288) alignment 
Range on Protein: 1314-1572
Range on HMM: 16-276/288.0
SSTGCSGLQSQFELLSQVTPDPDDVFCDSAKaHSDKNRSTSYLPQENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYK
| .. .|...... |...  . ..     |.   .|||    || .   | ||.     .. ||||||. |...||..| .|.|. .|  |||... ..|
sarnrtgfseeynsLaalektksvtagrlav.nakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

VSAIVMLCGLEEDGEESCYQYWRDSDV-VQFGEYFIKVEFSKECNGYIERKFHIRsdKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIg
.| |||| .| |.|.. | .|| |.|  ...|.  ...  ||| . ...||. .   |...  .. |.| . ||..|| .  . .|.... |   .|.  
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.

GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
 ||..||||. | |.|.. ..   ... ..| ..||. . . .|....  | ||.||  ||.|. 
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1333-1579 2.2e-52 172.9 In-house 29-281 (315) alignment 
Range on Protein: 1333-1579
Range on HMM: 29-281/315.0
PDPDDVFCDSAKA--HSDKNRSTSYLPQENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEES
||||     .|.      |||    || ..  | |     . .. ||||||. .. . ||.| .| | . .  |||.|....||..|||.  ..|.   .
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CYQYWRD--SDVVQFGEYFIKVEFSKECNGYIERKFHIRsdKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSG
| ||| |  .| |.||.. ...   . . . . ||. .|  | |.|  | | | |.||. || ..  ..|..| .|    ..    ...||||  | |.|
crqywPdrkadsvefGsikvellsleadtdgvarklvtr..kseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtG

VYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINS
| .|.   ..| | . .||||.. | .|. .|  | | |.|. |||.. . |    
vvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1051-1287 6.4e-51 167.8 In-house 33-274 (287) alignment 
Range on Protein: 1051-1287
Range on HMM: 33-274/287.0
ENK----VYNRFRNITPYDDNRIVLTPWPQLDkcqTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNS
 ..      ||. .. |.||.|..|.  ..|    . | || |. .| .  .|||.|||.  |. ||||......  |....|   | .. || .|||. 
aeelaavkknryadvlPiddtrvllsaegelG...sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

tGDNDHFGPFTVTLINEQ-VYPDFVIRQLNVkIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV-----MATWSPSKGPILVHCSAGVGRTGTF
       | ..|.|.. .   |.. .| | . |   ..... . |..| ||||....  |  |. .  .|     .|  .   ||..||...|.||.|..
.evPmrvGGysvvlldydikePeygvralrl.idletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil

IAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVL
.|. . ... .  | ||.  .| |||..|  .||.  |. .| .|. 
latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPRB_pd Subfamily PTPRB 1319-1576 6.9e-51 168.0 In-house 25-286 (293) alignment 
Range on Protein: 1319-1576
Range on HMM: 25-286/293.0
SGLQSQFELLSQVTPDPDdVFCDSAKAHSDKNRSTSYLPQENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIV
 ... ..| |..|  |   | ...... ..||| |  || ..  | |     .... ||||.|..||. .. || .| |. .|  |||.|. . |.|.||
lrfseeyeelkavgkdqa.vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiiv

MLCGLEEDGEESCYQYWRDS-DVVQFGEYFIKVEFSKECNGYIERKFHIRSdkDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQ-QKIGGGPV
||  | | | . | .|| .  . |..|.  ...  ..| . .. |...|.   .... .| |.. | ||. ||  ...|.|. .  | ... ..   .|.
mltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPi

VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLA
|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |.... ..| 
vvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1348-1578 1.3e-49 163.7 In-house 45-279 (515) alignment 
Range on Protein: 1348-1578
Range on HMM: 45-279/515.0
DKNRSTSYLPQENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRD--SDVVQFGE
 |||    || ..  | |     . .. |.||||. ..   ||.| .| | . .  |||.......|..|.|.  |.|.    | .|| |  .| |.||.
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGs

YFIKVEFSKECNGYIERKFHIRSDKDesSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV
. ...   . | | | ||...  ..|  |  | | . |.||. || .. ...|..| .|   ....   |...|||  | | ||..|.   . . |   .
ikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrm

VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAIN
||||.. . .|. .|  | | |||. ||...   |   
vdvfnfvtnirqkrpylvqtqeqyafiygavledllwr
0041856 (Phosphotyrosine protein) phosphatases II 1052-1297 4.5e-49 161.8 In-house 1-178 (182) alignment 
Range on Protein: 1052-1297
Range on HMM: 1-178/182.0
NKVYNRFRNITPYDDNRivltpwpqldkcQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTnlkegtkskCEQYWPnstgdnd
|. .||...| ||| .|              .| ||....|.   |.||| |||...|. ||.|......  .||..|         .|.|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

hfgpftvtlineqvypdfvirqlnvkiyngSNDSHTLTQYHLTSWPDHGVPDyATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDIALEQak
                              ..  .. .||. ..||||||||    | .. ..| .    ..||.|||||||||||||..|... ...  
..............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl..

reGvVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCGDTEI
  | |..  .|. .|..|..||.|..||.||..|.|| .....|..
..g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_PTPN6_pd Subfamily PTPN6 1297-1580 1.3e-48 160.6 In-house 4-302 (306) alignment 
Range on Protein: 1297-1580
Range on HMM: 4-302/306.0
IPSNEYEMKLRELKEIDSSTGCSGLQSQFELLSQVTPDPDDVFCDSAK-AHSDKNRSTSYLPQENFLVTLKEN----NGYINASYLSGY--REKKAFIIA
. ..| | . .||.. ..|.. .|.. .|| |.|          ..||     |||  . || ..  |.|||.    . ||||.|...    ..|..| .
llakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiat

QSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSD-VVQFGEYFIKVEFSKECNGYIERKFHIR-SDKDESSWDVIQLQVTDWPQDGVVR
|  .|.|  |||.|... .   |||.    | |.| |..|| |.    ..|.. ..   .|. . || |....   .|.... .|.|.. ..||. || .
qgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpk

EPRTVLQVIDDVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINST
.| .||. ..|| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. | ||. . | | | .||  .| .| |..  ...
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1345-1575 1.7e-48 160.1 In-house 27-268 (274) alignment 
Range on Protein: 1345-1575
Range on HMM: 27-268/274.0
AHSDKNRSTSYLPQENFLVTLK------ENNGYINASYLSGYRE-KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVV-
 .. ||| .. || ||  |.|.      |.  |||| |. ||.| .||.. .| |. ||  |||.||   .|. ||||  |.|  |. | .|. |.  . 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

---QFGEYFIKVEFSKECNGYIERKFHIRSDKDESSwdVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIG
   ..|.  ||||  .|.|.|  ||. ... ..| |  |.    ||||   . ....|.|.....| . ...     .|||||||  . | |.. ..||.
iserygdveikvekiverndysvrklvlkylerers..vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFL
. | ..|.||||....  .|  . | | | |||  |. .. ..|
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_CG7180_pd Subfamily CG7180 1326-1579 1e-47 157.3 In-house 20-294 (296) alignment 
Range on Protein: 1326-1579
Range on HMM: 20-294/296.0
ELLSQVTPD--PDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKE-----NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGL
.|. ..||    .|  ..  |   .|||    .| ... | |..     .. ||||.|  ..  ||..|. . |...|  .||... | ..||.|.|.  
klelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtkt

EEDGEeSCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSD--------KD--ESSWDVIQLQVTDWPQ-DGVVREPRTVLQVIDDVIHRQQKI-
 .  .  . .||      |.|| |...  .|.      |.|..           |.       | ..|.| |.  | |     ......  |   ..|. 
fdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd

---GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAINS
     |||||..|| .||||||... . ||. . |. ||||.  | .|||.|. | . |.|  ||||. ...  | 
edpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1323-1573 1.9e-47 157.0 In-house 27-286 (325) alignment 
Range on Protein: 1323-1573
Range on HMM: 27-286/325.0
SQFELLSQVTPDPDDVfcDSAKAHSDKNRSTSYLPQEN---FLVTLKEN--NGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCG
 .|.||  . .    |      .  .|||    .. ..    |.|.|..    |||||||  ...|. |. ||.|. .|  |.|....|.. | .|.|  
hefgllpsddgiakkv..amkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlne

LEEdGEESCYQYWRDS--DVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-----GGGP
|.. |...| .|| .   . ..||   .|.   .|   |. |.....  |.  .  | |.|.  |.. || . | |.. ... | . ....     . .|
ldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastp

VVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDK
..||||. | |.||. |.   |..   |  ||.|.. | .|. .|  | | .||. ||. . .
ilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1343-1570 2.1e-47 157.0 In-house 58-286 (319) alignment 
Range on Protein: 1343-1570
Range on HMM: 58-286/319.0
AKAHSDKNRSTSYLPQENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCgleedgEESCYQYWRDSDVVQ
 .   |||| .  |. ..  | |.  .|     |||||...||. |. .| || |..||  |||.|| .|..|.||.|       .. | |||    |..
ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

FGEYFIKVEFSKECNGYIERKFHIRSD-KDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQC
 ... .||.  .|.. |. |....  | | .   .. |     ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. 
eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrm

KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
| |  |||... . .|. ..  |  | ||  ||  
keekqvdvynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1348-1576 3.7e-47 155.8 In-house 51-281 (315) alignment 
Range on Protein: 1348-1576
Range on HMM: 51-281/315.0
DKNRSTSYLPQENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVVqFGEYF
.|||    .. ..  | |     ...  |.||... ||  |. .| ||.|  .. .|||... ..... |||| .| |. .. . .|| | .|. .|.. 
qknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkvi.yGkit

IKVEFSKECNGYIERKFHIRSDkdESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD
.     .  . |  | . . ..  .   .|.||..| ||. || .   .....|  |   ...   |..|||||. | |.| .....  |.| .|| ..|
vtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaid

VFQVTKAVRRSKPGAVTTLEQYTSIYDVI-DKFLA
|... . ||. . ..| ..|||  |||.. . |..
vynfitgvrqnrikmvqvaeqyqfiydalletfvc
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1345-1571 5.1e-47 155.7 In-house 24-251 (284) alignment 
Range on Protein: 1345-1571
Range on HMM: 24-251/284.0
AHSDKNRSTSYLPQENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCgleedgEESCYQYWRDSDVVQFG
   |||| .  |. ..  | |.   |     |||||...||. |. .| .| |..||  |||.|| .|..|.||.|       .. | |||    |.. .
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

EYFIKVEFSKECNGYIERKFHIRSD-KDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKA
.. .||.  .|.. |. |....  | | .   .. |     ||. ||   |  ...... | | ..|  .  ..|||||  | |.|||  . . |.. | 
rfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmke

EGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|  |||... . .|. ..  |  | ||  ||  .
ekqvdvynfvrdlrqqrntlvqdlvqykfiysal
0036282 (Phosphotyrosine protein) phosphatases II 1083-1284 9.5e-46 151.0 In-house 3-164 (174) alignment 
Range on Protein: 1083-1284
Range on HMM: 3-164/174.0
TYTNASYIDGYSNRTKFIASQGPMKrtlvdFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNstgdndhfgpftvtlineqvypdfvirqlnvkiyNGS
.| |||..|..   ...||.|||..     ||.......  ..||....||  . || .|||                                   . .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lre

NDSHTLTQYHLTSWPDHGVPDYATpLMSLHKQVMATWSP-SKGPILVHCSAGVGRTGTFIAIDIALEQAKrEGVVDIGGIVNRLRQQRMKMVQTLDQYVF
  ...  ||. . |||||||| .. | .. |.|    |  ..||.|||||||||||||..|... | . . |..||.  .| .||.||..|||| .|| |
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

LHD
|..
lyy
subfamily_PTPN12_pd Subfamily PTPN12 1343-1574 1.2e-45 150.6 In-house 37-276 (290) alignment 
Range on Protein: 1343-1574
Range on HMM: 37-276/290.0
AKAHSDKNRSTSYLPQENFLVTLK-----ENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDS--DV
.. .  |||    || ..  |.|.     |...||||... |  .|...| ||.|. .|  |||.|| ...|. .||.| . | |   | .|| ..  . 
keenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee

VQFGEYFIKVEFSKECN-GYIERKFHIRSDKDesSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQ
..|||. ...|  | .. ... | .... .|.  |  | |.. |.||  || . . ..|..|..| ..|.     |.|||||  | | |. ... .  |.
lefgefevtleeekavdddflirtLkveaqke..srkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrel

CKAEGV---VDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKF
 ||| .   .|||..   .|. .. .| | |||. .|  . ..
lkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_PTPN23_pd Subfamily PTPN23 1316-1571 1.3e-45 150.5 In-house 12-276 (288) alignment 
Range on Protein: 1316-1571
Range on HMM: 12-276/288.0
TGCSGLQSQFELLSQVT-PDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKE-NNGYINASYLSGYREK-KAFIIAQSPMENTARDFWKMIVDYKVSAI
 | ..|. .|..| |    .  .  .  || .|.||||.  || ..  |.|.. .. |||||.. .       ||..|.|...|. |||.|... |.| |
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssvi

VMLCGLEEDGEESCYQYWR--DSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIH---RQQKIG
|||   || |.... .||     . |.||.. . ..  .| . ..||.....  . .   .|  ||.| ||. ||   | |.||..| | .    .|.  
VmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrks

GGPVVVHCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
  |.|||||  | |.||.. |   ...  | .|..|. || . .|. .   | . ||.   |...
ktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1054-1288 2.2e-45 149.5 In-house 58-281 (290) alignment 
Range on Protein: 1054-1288
Range on HMM: 58-281/290.0
VYNRFRNITPYDDNRIVLTpwpqlDKCQTTYTNASYIDGYsnRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHF
  ||.....  |  |..|      |  .  |  | |..|   .. || .||..| | .|.||.. |||   |||. .| |  |.|||||.|.  |.   |
kknrykdvvcndktrvilk.....dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

GPFTVTLINEQVYPDFVIRQ-LNVKiYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDIALEQAKR
| .||.  .|.   . .|.. | |.    |  .| |  ... ||||. |.  .  |. . . .        ||. ||||||.||||||.||...|.    
Geitvlcseeddkdaniikktlsvr.dkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilld

EGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
   .|. ..|  ||. |.. ||   ||. | ...|.
Gkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1042-1288 2.9e-45 149.3 In-house 22-257 (267) alignment 
Range on Protein: 1042-1288
Range on HMM: 22-257/267.0
KST-VIGFSQENKVYNRFRNITPYDDNRIVLTPWPQLdkcqttYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGtksKCE
.||    ....|.  ||. .  ||||.|..|    .       | ||||..||  . .||. |.|.| |  ||. .| ..|   ||..|.  ..   .  
sstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nir

QYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNdsHTLTQYHLTSWPD-HGVPDYATPLMSLHKQvmATWSPSKGPILVHCSAGVGRTGT
..||   |.  ..  .||    |.   |. |  |..|. | |   | .| |.   |        |  ||. .  .          |..|.||.||||.||
lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa..hnvtlyyykkwnintnnkpylkplfgilak..nqlengnrPlvvacsdGvGrsGt

FIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
|. ||  ||.||.|||.||   . ..|.||. .|.|...|...|. . |
flvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1347-1575 3.4e-45 149.3 In-house 42-276 (281) alignment 
Range on Protein: 1347-1575
Range on HMM: 42-276/281.0
SDKNRSTSYLPQENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSD-VVQFGE
  ||| .     ..  |..     ..|. ||||....||...|..|..|.|. ..  .||.|....|||||||.    | |   |..|| | .  ...|.
vlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygd

YFIKVEFSKECNGYIERKFHIrSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-G
. .| . ..| . ||||||.. . ..  . .| ||. | ||. ||  ... .|.  ..| . ..|    |.|.|||  | |.|.| ..   .....||  
vtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaele

VVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFL
 .|| .| . .|...   | |. ||. .| .. . |
eldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN9_pd Subfamily PTPN9 1305-1572 9.2e-45 147.9 In-house 2-287 (297) alignment 
Range on Protein: 1305-1572
Range on HMM: 2-287/297.0
KLRELKEIDSSTGCSGLQSQFELLSQVTPDpDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKENN-----GYINASYLSGYREKKAFIIAQSPMENTARD
...|| .   ..| .||. ... . . ..    . .   .| . ||| |  |  ..  |.|.. .      ||||... ||..||||| .| |...| .|
eieelvayvkekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWKMIVDYKVSAIVMLCGLEEDGEESCYQYWR--DSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVID
||.|. . .|  |||   ..| |   | |||   . .. .||.. ...   .| . | .|...|.  |.| |  |.  |.. ||  || ..  ..|.|..
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

DVIHRQQ------------KIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
 | ..|             .. | |.|||||  . |.| .... | |.. . .|.|||... | .|  .  .. | |||.  |  . 
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl
subfamily_PTPN3_pd Subfamily PTPN3 1322-1571 3.9e-44 145.7 In-house 18-271 (280) alignment 
Range on Protein: 1322-1571
Range on HMM: 18-271/280.0
QSQFELLSQVTPDPDDVFCDSAkAHSDKNRSTSYLPQENFLVTLKENN-GYINASYLS----GYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC
  ||| | .  |. .   .  . .  .|||    || ..  |.|||..  ||||.|..    .    . .|..| |...|| |||.|. . |.| |||| 
laqfeqlyrkkpglaisaarkp.enlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

GLEEDGEESCYQYWRD-SDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKIGGGPVVVHC
 | |.|   |.||| . .| ...||. .|.| ..| . |. |.. ..  . . .  ..||| ..||. ||  ..  .|.... | .....    ||||||
tlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhC

SDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|  . |.||.  . . |    |.  | . .. . .|  .   | | .||. . . |
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1346-1576 1.2e-43 144.0 In-house 20-265 (270) alignment 
Range on Protein: 1346-1576
Range on HMM: 20-265/270.0
HSDKNRSTSYLPQENFLVTLKEN-----NGYINASYLSGYRE-KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDS--DVVQ
..  ||..  ||. .  |.|.|        |||| |. |. . ||..| |..|...| ..||.||.. ||.||||. ||||.| . | .||  .  . |.
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

FGEYFIKVEFSK--ECNGYIERKFHIRsDKDESSwDVIQLQVTDWPQDGVVREPR------TVLQVIDDV-IHRQQKIGGGPVVVHCSDTVSRSGVYCSV
. . .|||  ..    .||| .. ... .| |.   ..  . ..||..||.||.        .|... .|  .....  ..|..||||. | |.|.   .
ledgkikvlalseekeegyiltrlrle.ekgeer.rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

SIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLA
 |...  . .. ||| .. ...|. ..  | . |||. .| .. ..  
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_PTPN14_pd Subfamily PTPN14 1338-1575 1.2e-42 141.0 In-house 41-296 (300) alignment 
Range on Protein: 1338-1575
Range on HMM: 41-296/300.0
VFCDSAKAHSDKNRSTSYLPQENFLVTLK----ENNGYINASYLSGY--REKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWR
. . . .   .|||    || |.  | |.    ...|||||| ..     ... .|.||.|.|.| .|||.|. . .|. ||||   |||| | ...|. 
lstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfP

DS----DVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDV---IH-RQQKI----GGGPVVVHCSDTV
..    . |.||.. .  .||.. . .| ......    .   .|. || ||||..|| ..... |. ...|    .  ....       ||.||||. |
kleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGv

SRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFL
 |.||   . . ..  . . ..|. .| . .|. .   | || ||. .|.|. |.|
GrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
0043147 (Phosphotyrosine protein) phosphatases II 1082-1283 4e-42 139.2 In-house 5-154 (172) alignment 
Range on Protein: 1082-1283
Range on HMM: 5-154/172.0
TTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLkegtkskceqywpnstgdndhfgpftvtlineqvypdfvirqlnvkIYNG
..| ||||.|.|   ..||| |||. .|| ||||......   ||..|.|                                               |..
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydp

SNDSHTLTQYHLTSWPDHGVPdYATPLMSLHKQVMA-TWSPSKGPILVHCSAGVGRTGTFIAIDIALeqakreG-VvDIGGIVNRLRQQRMKMVQTLDQY
.. ...  ||. ..|||||||  .  |... ...       ..||.|||||||||||||..|... |        . ..  .|. .|..|...||. .||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqy

VFLH
 ||.
rfly
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1044-1289 5.7e-42 138.8 In-house 34-276 (307) alignment 
Range on Protein: 1044-1289
Range on HMM: 34-276/307.0
TVIGFSqENKVYNRFRNITPYDDNRIVLTpwpqLDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
||  ||  |   ||....   | .|||..    .|   . |  | |.    .  |||..|||.. |  .|| .. |||  |..|. .. | .| ||||||
tveafs.antdknryqdvkcqdkgrivvk....fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqyw

PNSTGDNDHFG--PFTVTLIN---EQVYPD-FVIRQLNVKIYNGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGPILVHCSAGVGRT
|   |..  ||  | |... |   ... ||  .|   ..|.  . ..| |....  . |||.|||.     . | . |       . |..|||||||||.
pleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqinltainlleav....rydtnpvvvhcsaGvGrs

GTFIAIDIALEQA-KREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLET
|| .|| .  ..  . .   |.  .|. ||.||   .||  ||..||  .|| 
GtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
0049260 (Phosphotyrosine protein) phosphatases II 1089-1284 1.4e-41 137.0 In-house 1-144 (152) alignment 
Range on Protein: 1089-1284
Range on HMM: 1-144/152.0
YIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWpnstgdndhfgpftvtlineqvypdfvirqlnvkiyngsndshtl
.|||| . ..||| |||.  || ||||.... .   |||.|.| | .| |||||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

tQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALeqakreGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHD
 ||. . |||||||| .  |. |.. .   .  ..||.|||||||||||||..|... |        |..  .|...|..|...|.. .|. ||..
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 1081-1288 4.6e-41 135.8 In-house 11-171 (176) alignment 
Range on Protein: 1081-1288
Range on HMM: 11-171/176.0
QTTYTNASYIDGYsnrtKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNDhfgpftvtlineqvypdfvirqlnvkiyn
  .| ||..|.|.    ..|| |||. ||| ||........   .|..|...|  . || .|||  .. .                              
dldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

gsndshtltQYHLTSWPDHGVPDYaTPLMSLHKQVMAtWSPSKGPILVHCSAGVGRTGTFIAIDialeQAKREGVVDIGGIVNRLRQQRM-KMVQTLDQY
         ||. . ||||||||. . |..| ...   .  ..||.|||||||.|||||..|..      ..|  ...  .. ..|.||. ..||| .||
.........qylhlpwpDhgvpdl.elllellefire.alkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQy

VFLHDAVLE
 ||....|.
rflyefell
subfamily_PTPN13_pd Subfamily PTPN13 1325-1575 5.4e-40 132.4 In-house 17-269 (273) alignment 
Range on Protein: 1325-1575
Range on HMM: 17-269/273.0
FELLSQVTPDpDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKENNGYINASYLSGYR--EKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDG
|. | .. |  |..     |.. ||||    || ..  |.|... ||||||..      ..  .|..| |. .|..|||.|. . |.. |.|.    |.|
fkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekg

EESCYQYWRDSDV---VQFGEYFIKVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTV
.  | .|| .|     .  . . ....  .. .|.  |.....  . . | .| .|. ..||  || ...  .||..  | . |.    ||.|||||  .
kvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGi

SRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFL
 |||.. .. . |.  . .  .|| .. . .|. . | | | .||  .| .| . |
GrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
0049772 (Phosphotyrosine protein) phosphatases II 1044-1288 9.6e-40 132.6 In-house 38-278 (314) alignment 
Range on Protein: 1044-1288
Range on HMM: 38-278/314.0
TVIGFSQENKVYNRFRNITPYDdNRIVLtpwPQLDKCQTTYTNASYIDGYsnrTKFIASQGPMKRTLVDF----------WRLI--WQEKPVSIVM----
....   .|.  ||. .| |.| || .|   | |.   . | ||||.||.    ||||.|||.. |.|||          ||..  .. ..  |||    
ilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------VTNLKEGTKSKCEQYWPNSTgdndhfgpftvtlineQVY--PDFVirqlnvkiyngsndSHTLTQYHLTSWPDHGVPDYATPL
                  ..| ...   .......                  ...  |...              ...  .|. . .||...|. .  .
vladelsrLdaAlgKtpllildgngneptaadlellk................eelydpelf..............erlgikylripvpDgsaplledfd

MSLhkQVMATWsPSKGPILVHCSAGVGRTGTFIAIDIALEQAkreGVvDIGGIVNRLRQQRM-----KMVQTLDQYVFLHDAVLE
  |  ... .. . .||.||||.||.||||||..... . .    || ..  .....|..|.      ....|.||.| ..|.||
efl..efieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1321-1571 2.1e-39 130.1 In-house 8-255 (267) alignment 
Range on Protein: 1321-1571
Range on HMM: 8-255/267.0
LQSQFELLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKE-NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLe
.. .|||. .....   . .  |.   ..||    || ..  | |.. .. ||||||. ||. |.|||. | |..||  ||...| |.||. ||.|    
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv.

edGEESCYQYWRDS--DVVQFGEYFIKVEFSKECNGYIERKFHIRSdKDESSWDVIQLQVTDWPQDGvvrEPRTVLQVIDDV-IHRQQKIGGGPVVVHCS
  ...   ..|     .  .. .  ..  . || | |    . ..  |.||. .|       |  .    . .  |. .  .  . | . |. |.||.||
..ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnint...nnkpylkplfgilaknqlengnrPlvvacs

DTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
| | ||| .  .   ||. | |||.|.|.  . .|  ..| | |.|.|  |....
dGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1049-1288 2.3e-39 130.0 In-house 46-285 (305) alignment 
Range on Protein: 1049-1288
Range on HMM: 46-285/305.0
SQEnKVYNRFRNITPYDDNRIVLT-PWPQldkcqtTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNST
.|| .  ||....   |.||. |  |||        |  | |.   .|  .|| .| |...|  ||| . .|.|  .| |. ||.|    || .|..   
aqe.agknrykdvgcldnnrvklegpwph......eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd

GDNDHFGPF--TVTLINEQ-------VYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGPILVHCSAGVGRTG
.|  .|      ...  |           . ....  . |    ....  |.||   ||| |||   . .. | ..      |||||| ||||||.||||
kdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtg

TFIAIDIALEQAKREGVVD-IGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
. . ..  |.|     ...    |....|.|| . .|| .||.|.|. .|.
svvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1033-1291 3.7e-39 129.5 In-house 25-272 (288) alignment 
Range on Protein: 1033-1291
Range on HMM: 25-272/288.0
YKAIYNGEDKSTVIGFSQeNKVYNRFRNITPYDDNRIVLTpwpqlDKCQtTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLK
|.   |.  . ..  | . | . .|..|.   |  |. |.     | ..  | .|  .    .. ..| .| |.. |.  .|... ..    |||...| 
yrdspneasidiidsfia.nptrdryenlprcditrvkls.....ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcell

EGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVmatwSPSKGPILVHCSA
|  | | ..|.|   |.. ..| .     ....  | ...   ..| .  ...  . . ||  |.|.|||.   . . | . .       . ||.||.||
ekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssa

GVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM
|||||||.| | ||||... .  . |  ....||..|.| .||  ||...|  ||| ..
GvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1043-1288 4.4e-38 125.5 In-house 29-267 (281) alignment 
Range on Protein: 1043-1288
Range on HMM: 29-267/281.0
STVIGFSQENKvYNRFRNITPYDDNRIVLTPwPQLDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQY
 ||.    .||  ||. ||   |  |. |      .|  | |  | ||     .  .| .||| | |  ||||.||||.  .|||. .. |  . || .|
ctvfnqpvnnk.knrylnipcldisrvqlkv.kmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVKiYNGsnDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPskgpILVHCSAGVGRTGTFIA
.|  .    .|  ..|.  .  |   .|  .||.  |.|  ... .|..    |||  ||. .  .. . ... |  .|     ..||||||||.||..|
fprnahcclqfdklsvsyedstvnkslvttrlnls.yeg..etrlithwlwkewpdwqvpessevmlkilrkirarstp....pvihcsagvgrsgtlma

IDIALEQAKRE-GVVDIGGIVNRLRQ-QRMKMVQTLDQYVFLHDAVLE
..|||.  .    . ||  || .||   |   ||||.||...   .|.
veialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0051429 (Phosphotyrosine protein) phosphatases II 1368-1575 5.5e-38 126.5 In-house 3-225 (272) alignment 
Range on Protein: 1368-1575
Range on HMM: 3-225/272.0
NNGYINASYLSGYRE---KKAFIIAQSPMENTARDFWKMiVDYKVSAIVMLCGLEEDGEESCYQYWR------------DSDVVQFGEYFIKVEFSKECN
 .|||||....||     ..... .. |...||.|||..  ......||.|...|| | . |..||             .   . .| ..... . . ..
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERKFHIRSD-KDESSWDVIQLQVTDWPQDGVVREPrtVLQVIDDVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVD--------V
 || |.. ..   . . .  | .|. |||| .|| .|.  .|.... . .      ||||.||||  ..|.|... . . |..  .| .||        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFL
... . .|.  |||| | |||  .|... ..|
eeaveelraqrpgavqteeqylflyeallell
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1367-1571 1.8e-37 123.8 In-house 27-235 (237) alignment 
Range on Protein: 1367-1571
Range on HMM: 27-235/237.0
ENNGYINASYLSGYRE-KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDV-VQFGEYFIKVEFSKECNGYIERKFHIRSD
 .  ||||.|| |.    | .| || |.|..  |||.|. . | | |||| || |  |. |..|| ..|    .| . . .   .|   |  | . .   
sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskr

KDESSWDVI-QLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLE
       .| | | | ||. || ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | |.| . |||...  ...   .|  . | .
ltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkd

QYTSIYDVI
||  |...|
qyvfihqti
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1323-1572 1.4e-36 120.9 In-house 24-276 (439) alignment 
Range on Protein: 1323-1572
Range on HMM: 24-276/439.0
SQFELLSQVTPDPDDVFCDSAKAHSD-KNRSTSYLPQENFLVTLKENNG-----YINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC
  || .. . ||   . .  |. ... |||  .  . .   |||.|  |     |||| |. || ..| .| .| | ..|. |||..... |.. ||||.
eifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmlt

GLEEdgeesCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKDES--SWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIGGGPVVVH
 | |      |.||  .. | .|.  ..|.   |   |. | |..  ..| .     |.|.. . ||.  |  .   ||. .  .   ..|   ||||||
nlve.....sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvh

CSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
||  | |.|   .. | ||| |.|  ||.  . | .|. .   | .| ||  ||. . 
csagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
0044763 (Phosphotyrosine protein) phosphatases II 1063-1288 2.3e-36 120.5 In-house 1-169 (178) alignment 
Range on Protein: 1063-1288
Range on HMM: 1-169/178.0
PYDDNRIVLTPWpqLDKCQTTYTNASYIDGYsnrtKFIASQGPmkrtlVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGdndhfgpftvtlin
|.|..| .|...   . . . |.|||.|...     ...|..|     .|...|.....  .||..|. .|. . || .||| ..|              
pldrtrvllsnl..eglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............

eqvypdfvirqlnvkiyngsndshtlTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQakreGVvDIGGIV
                           ||. . .|||||||    .. ... . .  ....||.||||||||||.||..|... ...    |. ..  ..
..........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeai

NRLRQQRMkMVQTLDQYVFLHDAVLE
...|..|. .|.. .|. .|..  |.
elvrerRp.ivpnpgqlrqLyefelr
0051082 (Phosphotyrosine protein) phosphatases II 1082-1287 8.6e-36 118.1 In-house 3-150 (151) alignment 
Range on Protein: 1082-1287
Range on HMM: 3-150/151.0
TTYTNASYIDGYsnrtkFIASQGPMKrtlvDFWRLIWQEKPVSIVMVTNLKEGTksKCEQYWPNSTgdndhfgpftvtlineqvypdfvirqlnvkiyng
..|.|.||..|.     ...|.||.     ||..|.....  .||......|    .| .|.|.                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sndsHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwsPSKGPILVHCSAGVGRTGTFIAIDIALEQakregvVDIGGIVNRLRQQRMKMVQTLDQYVF
    ..........|||.|.|..   ..........   ...||.|||||||.|||||..|... |..      |..  ... .|..|. .||. .|..|
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

LHDAVL
.. |.|
qlfall
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1052-1290 9.8e-36 118.2 In-house 35-270 (285) alignment 
Range on Protein: 1052-1290
Range on HMM: 35-270/285.0
NKVYNRFRNITPYDDNRIVLTpwpqldKCQTTYTNASYIDGY-SNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDN
|   ||. ..   .. |.||       . .  |  ||..     ... .|..|||.  || |||..|.|||   ..|.  | ||   ||  |.|.  |. 
npdlnryadvrcieetrvvlk......nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

DHFGPFTVTLI--NEQVYPDFVIRQLNVKI-YNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtWSPSKGPILVHCSAGVGRTGTFIAIDIAL
 .|| . .||   .|.     ..  | |    . |..   . . ..  |||.  |. | |.. |.| |     | . || |||||||||| ||. || | 
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidyat

EQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
 .   .  ...  ||  .|  |.. ||.  |..||.  ..| .
irimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_ptpA1_pd Subfamily ptpA1 1044-1247 1.3e-35 118.0 In-house 39-253 (418) alignment 
Range on Protein: 1044-1247
Range on HMM: 39-253/418.0
TVIGFSQENKVYNRFRNITPYDDNRIVLTPWpqLDKCQTTYTNASYIDGYSNrTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
|  |  . |   ||. || | .  |. |      ||  . | || ||||     .||..|||.  |. ||||..|...   |||..   |  . ||..||
tsegdkkhntsknrytnilpvnhtrvqlkki..qdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdryw

PNSTGD---------NDHFGPFTVTLINEQVYPDFVIRQLNVKIYNgSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVM------ATWSPSKGPILV
|.  |          |. || ..| |..    |.  |   |...     ... .|||.   |||| .||.. |.  | . .          |  . ||.|
peqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf.egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

HCSAGVGRTGTFIAIDIAL
|||||||||||| .  | .
hcsagvgrtgtfctavimm
PTPc_DSPc_SM00012 1188-1288 3.3e-35 115.8 In-house 2-105 (105) alignment 
Range on Protein: 1188-1288
Range on HMM: 2-105/105.0
LTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSK--GPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIGGIVNRLRQQRMKMVQTLDQYVFLHD
...|| |.|||||||........| ..|.   . |.  .|..|||||||||||||.|.||.|.| ..| . |||  ||..||.||..||||..||.||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1052-1289 2.2e-34 113.5 In-house 55-288 (305) alignment 
Range on Protein: 1052-1289
Range on HMM: 55-288/305.0
NKVYNRFRNItPYDDNRIVLTPWPQldkcQTTYTNASYIDGY-SNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDN
..  ||.... | .|. .|.   |.     . |  | |.        .||..|||. .|. .|| .. |.|   |||. .  |  | || |||| . |..
aitknryqdv.pcqdqsavkldkps....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

DHFGPFTV-TLINE----QVYPDFVIRQLNVKiYNGsNDSHTLTQYHLTSWPDHGVPDYAtpLMSLhkQVMATWSPSKGPILVHCSAGVGRTGTFIAIDI
 ..    |   .      .  ..  |  ||.  |.| ... .. . . | ||| |||     | ||  .....   || ||.||||||.||||| .||. 
lelksgivvenvsgskpmerdaeiqitllnlt.ysg.dqkmsvrhlqwtewpdrgvppck..ltsl..ellsairgskvpivvhcsagigrtgtivaiey

ALEQ-AKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLET
 ||. |.   .  .  .|. ||.||   .|.  ||.|.|  .|. 
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1031-1287 2.5e-34 113.2 In-house 31-287 (310) alignment 
Range on Protein: 1031-1287
Range on HMM: 31-287/310.0
EQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTpwpqLDKCQ-TTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVT
 ||. .   .| |      ...   ||. ..   |. |. |.    .|| .   |  | |.     |. || ||||.. |..||||.|.||.  ||... 
kqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk....idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

NLKEGTKSKCEQYWPnSTGDNDHFGPFTVTLINEQVyPDFVIRQLNVKIYN--GSNDS-------HTLTQYHLTSWPDHGVPDYATplMSLHKQVMATWs
.  |  . ||  ||| | |  . .|   || ..|    .| | .| | .       |          ..  .   ||| ||||      .. ....|   
kvgeegrpkcvgywp.slgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htvpqrllaqv.

pSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVL
  .|| .||||||..|... .|.........|   ||.  ..  |...|.. .||  ||....   .
.rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
0041856 (Phosphotyrosine protein) phosphatases II 1348-1571 2.9e-34 113.6 In-house 3-167 (182) alignment 
Range on Protein: 1348-1571
Range on HMM: 3-167/182.0
DKNRSTSYLPQENFLvtlkeNNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCgleedgeesCYQYWRdsdvvqfgeyfikvef
|||| . .|| .. .     .. ||||... |..  . ||..| |. .|  ||..|. ......||.|.         ...||                 
dknrysdilpydhsr.....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp................

skecngyierkfhirsdkDESSWDVIQLQVTDWPQDGVVRePRTVLQVIDDVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGvVDVFQVT
                  ..    .||.. . || .||   ....|. |..|..      ||||.||||  |.|.|...   . ...    | |..... 
..................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeav

KAVRRSKPGAVTTLEQYTSIYDVI
| ||. .||.|.|..||  .....
klvrsrRpgmvitpnqyfflqlal
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1345-1578 3.4e-34 112.9 In-house 37-280 (287) alignment 
Range on Protein: 1345-1578
Range on HMM: 37-280/287.0
AHSDKNRSTSYLPQENF--LVTLKENNG--YINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDV-VQFG
|   ||| .  || ..   |.. . . |  |||| |...|....||| ||.|.  | ||||..... ........    |..   ||.|| . .| .. |
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYFIK-VEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVRE----PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQ
 | .  .....    |  | . .   . . .  | ||.. .||....        | ||.| . .  ...  . ||.|||..  . |||.. .. . ...
GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr

CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFLAIN
 .  | ||| .|   .|  . . | .  |.  .|. .  .   |
ledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
0036282 (Phosphotyrosine protein) phosphatases II 1369-1569 5.6e-34 112.7 In-house 2-164 (174) alignment 
Range on Protein: 1369-1569
Range on HMM: 2-164/174.0
NGYINASYLSGYREKKAFIIAQSPMEntardFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDsdvvqfgeyfikvefskecngyierkfhirsDKDES
. |||||.|....  . .|. | |..     ||.|. .......|||. ..|.| . |..|| .                               ...  
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SWDVIQLQVTDWPQDGVVREPRtVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIY
.  .||.. . || .||   .  .|.... | . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

D
.
y
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1182-1329 6.3e-34 112.0 In-house 85-233 (440) alignment 
Range on Protein: 1182-1329
Range on HMM: 85-233/440.0
SNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATW-SPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYV
. .|.|| |||  .|||.||| .| |.. . ..|  .    ..||.|||||||.||||  ||.|  | .|||   .||  ..| .|..| .|||| .||.
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FLHDAVLETVMCGDTEIPSNEYEMKLRELKEIDSSTGCSGLQSQFELLS
|.|.|||| ..|||| |  ..   .. ...  .  |  | || .||  |
fvheavlegllcgdtliledditerveqiqwpnphtdksplqqefegys
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1333-1573 4.8e-33 109.1 In-house 30-234 (392) alignment 
Range on Protein: 1333-1573
Range on HMM: 30-234/392.0
PDPDDVFCDSAK--AHSDKNRSTSYLPQENFLVTL-----KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGees
|.||     .|.      |||    || ..  | |       .. |.||||. ..  .||.| .|.|   .  |||.|. . .|..|.|.  |.|     
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...

cyqywrdsdvvqfgeyfikvefskecngyierkfhirsdKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIgGGPVVVHCSDTVSRSGVY
                                       | ..   | | ..|.||...| .   ..|..| .|     .    |...|||  | |.|| 
.......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvv

CSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDK
 |.   . ..|   .||||..   .|| .|  | | |||. ||  . .
isidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1086-1282 6.6e-33 108.7 In-house 79-273 (301) alignment 
Range on Protein: 1086-1282
Range on HMM: 79-273/301.0
NASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQV-YP-DFVIRQLNVKIYNGSN
 | .|.   .  .|||.|||.| |  ||| .. | .   |||...  | ...|||.| | ..... . | |.... |...    . . |.|.|.   |  
hanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkf

DSHTLTQYHLTSWPDHGVPDYATPLMSLhkqvMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFL
...|.| |  ..|.|.|||   . |. |    |     |. ||.||||||.||. .||. ..   . . .  ...   ...||..| . |||  |  ..
atrtvthyqysewtdrgvPkshaelfdl....melvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_PTPN1_pd Subfamily PTPN1 1328-1568 8.5e-33 108.3 In-house 12-264 (290) alignment 
Range on Protein: 1328-1568
Range on HMM: 12-264/290.0
LSQVTPDPDDVFCDSAKAHSDK--NRSTSYLPQENFLVTLK-ENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEE
. ... . .|. . .|| ....  ||     | .   ..|. ..| ||||| .   . |. .|..| |. ||.  ||.|. . |  |.|||  . | .. 
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

SCYQYWR---DSDVVQFGEYFIKVEF--SKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ-KIGGGPVVVHCSDT
 |.|||    ... ... .  .||..   .. . |. |....   | . . ....   | ||  || . | . |. . .| .    .   ||.|.|||  
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VSRSGVYCSVSIGLEQCKAEG---VVDVFQVTKAVRRSKPGAVTTLEQYTSIY
. ||| .| |   | . ....    ||. .|  ..|. . | . | .|    |
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1369-1568 1e-32 108.2 In-house 36-234 (239) alignment 
Range on Protein: 1369-1568
Range on HMM: 36-234/239.0
NGYINASYLSGYR-EKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDvVQFGEYFIKVEFSKECNGYIERKFHIRSDKDE
. |||||||  |    ||.| .|  .| .. |||.|. . .   |||| || |  .. |.||| ||   .. .  . .  ..    || | | .    . 
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skycnlrvtlrktevfadyiirtfvmsqvgqt

SSWDVIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
    | | ..| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |
eeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfi

Y
.
h
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1369-1568 1e-32 108.2 In-house 35-233 (239) alignment 
Range on Protein: 1369-1568
Range on HMM: 35-233/239.0
NGYINASYLSGYR-EKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDvVQFGEYFIKVEFSKECNGYIERKFHIRSDKDE
. |||||||  |    ||.| .|  .| .. |||.|. . .   |||| || |  .. |.||| ||   .. .  . .  ..    || | | .    . 
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skycnlrvtlrktevfadyiirtfvmsqvgqt

SSWDVIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSI
    | | ..| ||. || .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| .  ||.|.  ||.|  .|  | | |||  |
eeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfi

Y
.
h
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1348-1571 1.6e-32 107.3 In-house 58-279 (290) alignment 
Range on Protein: 1348-1571
Range on HMM: 58-279/290.0
DKNRSTSYLPQENFLVTLKE--NNGYINASYLSGYreKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDS--DVVQFGEYFI
 |||      ..   | ||.  .  |. | |. |   |  ||..| ....|. |.|.|... ||.|||||| | |||   | ||. .   .|. |||. .
kknrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitv

KVEFSKECNGYIE-RKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLeQCKAEG-VV
    ... .  |  . . .|  ..  .  .  |..  ||.  |     ..|...  .  |.     ||||||||  . |.| . .. .|| |.  .|  .
lcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qilldGkel

DVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|. .. .|.|.|. ..|    ||  . ...
dlldlvralrnsrlnsvqvdiqylalveil
subfamily_PTPRN_pd Subfamily PTPRN 1321-1570 4.3e-32 106.0 In-house 31-287 (297) alignment 
Range on Protein: 1321-1570
Range on HMM: 31-287/297.0
LQSQFELLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKEN-----NGYINASYLSGYRE-KKAFIIAQSPMENTARDFWKMIVDYKVSAIVM
|. ..| | .   .|      .|.   .||||.. || ..  |.|||.     . ||||| .      . |.| .|.|. .|  |||.|. .  |  ||.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LCGLEEDGEESCYQYWRDSDVVQFGEYFIKVE-FSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIhRQQKIGGGPVVV
|. |||.| . |..|| |     .. | ...      |. |. | |...  . . .  | |.    ||. ||  .....|.    |  .  .    |.||
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivv

HCSDTVSRSGVYCSVSIGLEQC-KAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
|||| . |.|||. . . |..  |    .|.    . .|  .|| | | .|.  .. .
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
0043147 (Phosphotyrosine protein) phosphatases II 1367-1568 1.4e-30 101.7 In-house 3-154 (172) alignment 
Range on Protein: 1367-1568
Range on HMM: 3-154/172.0
ENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLeedgeescyqywrdsdvvqfgeyfikvefskecngyierkfhiRSDKD
|.. |||||||..|.  . ||. | |. ||  |||.|. ......||.|..|                                             |..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

ESSWDVIQLQVTDWPQDGVVrEPRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeG-VvDVFQVTKAVRRSKPGAVTTLEQYT
  .  .||.. . ||  ||   .. .|.... . .....  ||||.||||  |.|.|. .   . |        . ..... . ||. .||||.. .|| 
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyr

SIY
 .|
fly
0046846 (Phosphotyrosine protein) phosphatases II 1367-1573 4.6e-29 96.8 In-house 10-171 (176) alignment 
Range on Protein: 1367-1573
Range on HMM: 10-171/176.0
ENNGYINASYLSGYRekkaFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDsdVVQFGEyfikvefskecngyierkfhirsdkd
..  ||||... |.|    .|. | |...|  ||..|. .....|.|.|. . | |  .|..|| .  . ..|                           
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..........................

esswdviQLQVTDWPQDGVVREpRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGVVDVFQVTKAVRRSKP-GAVTTLEQYT
       | ....||  ||    . .|.... .  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| ||| 
.......qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

SIYDVIDK
 .|... .
flyefell
subfamily_egg_pd Subfamily egg 1046-1296 5.1e-29 95.9 In-house 34-279 (307) alignment 
Range on Protein: 1046-1296
Range on HMM: 34-279/307.0
IGFSQENKVYNRFRNITPYDDNRIVLtpwpQLDKCQ--TTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGtkSKCEQYW
  .|..|.   | . .   |  |. |    .| . |    .  | ...|     .|| .| |.| |  ||||...||.   |||.|  ||    .|| ||
taasdnnlekarskrvhckdssrvkl....elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyyw

PNSTGDNDHF--GPFTVTLINEQVYPDFVIRQLNVKIyNGSNDSHTLTQYHLTSWpdHGVPDYATPLMSLHKQVMAtwspsKGPILVHCSAGVGRTGTFI
|..  |.  .  | . .. .. .  .| . |  ..|.  |..|     ..    .  . . |  .||  | |   .       |..|..  || ...|..
pkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqgdv..nnssdvysplrvlrklrnl.....skpvvvqdilGvskaatlv

AIDIALEQAKREGVV--DIGGIVNRLRQQRMKMVQTLDQYVFLHDAVL---ETVMCGDTE
||.||| .  |  ..   .   |  ||..|   |..  .|.|..  ||     |.    |
aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsake
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1048-1215 7.7e-29 95.5 In-house 27-193 (297) alignment 
Range on Protein: 1048-1215
Range on HMM: 27-193/297.0
FSQENKV--YNRFRNITPYDDNRIVLTPWPqldkCQTTYTNASYIDGY--SNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYW
 .. |     ||.|.|  .||.|. |   .     .. | || |.      .  |.| .|||...|. |||.|....    ||||..|.|. ..||  ||
sakrnsslrknryrdilatddtrvkllrvi....terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PNSTGDNDHFGPFTVTLINEQV--YPDFVIrqLNVKIYNGsNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQV
|.. ... . | . |  . .    .   ..   .....   ..|  ..     ||||||||     |  .. ||
psvvqerlkagdvvveflsstsdefdrvil..telqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1377-1571 9.1e-29 95.0 In-house 229-434 (440) alignment 
Range on Protein: 1377-1571
Range on HMM: 229-434/440.0
LSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEdgeESCYQYWR-DSDVVQFGEYFIKVEFSKECNGYIERKFHIRSdKdESSWDVIQL
. ||  |.||| .| |.. |  |||... ||..|.|.||  |..    .|  ||  ..  | || . .    |.. |    | . ..  | |   .. |.
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelky.k.eevheirqf

QVTDWP----QDGVVREPR---TVLQVIDDV----IHR---QQKIGG-GPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTT
.|  ||     |||  . .   .|||..| .    | |   | . |   |..|||   .  |||.|.|   ||| . .| .||||  . .| |.|  | |
evqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvpt

LEQYTSIYDVI
| .|   | ..
ltdyllcykll
0048076 (Phosphotyrosine protein) phosphatases II 1141-1287 7.9e-28 92.3 In-house 1-140 (145) alignment 
Range on Protein: 1141-1287
Range on HMM: 1-140/145.0
QYWPNSTGDNDHFGPFTvTLINEQVYPDFVIRQ-LNVkIYNGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSkGPILVHCSAGVGRTGT
.|||.   ..  .|... | .. . . |. |.  ||.  .. .. ... .||. ..|||||||| .  |... ... .  .   ||.|||||||||||||
pywpseilpglylgslp.taldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgt

FIAIDIALEqakrEGvVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVL
..|... |.    .| |..  .....|.||...|.. .|. ||....|
lvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1031-1293 1.1e-27 91.6 In-house 23-279 (312) alignment 
Range on Protein: 1031-1293
Range on HMM: 23-279/312.0
EQYKAIYNGEDKSTVIGFSQeNKVYNRFRNITPYDDNRIVLTPwpqlDkcQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTN
 .|||. |    | .  | .  |  ||. ||  .|  |. |.     |  .  |  | ..   ..  .|...|||.. | . ||.|      .||.... 
keykavgnivsdsectaflk.fkdlnrypniqcwdrgrftlag....d..enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

LKEGTKSKCEQYWPNSTGD---NDHF--G-PFTVTLINEQVYPDFVIRQLNVKIYNGSNDShTLTQYHLTSWPDHGVPDYATPLMSLhkqvMATWSPSKG
. | .  || .|  .  |    .||       |   |  .       | |.| .    ..|  | .|  .||||||.||     . |    ...    | 
fvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrl....lsavkkdkk

PILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCG
|.. |||||||||||.. |.  .   .     ..  .   ||..| . |... |||.   .||| ... 
pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
0049260 (Phosphotyrosine protein) phosphatases II 1377-1569 1.1e-27 92.0 In-house 2-144 (152) alignment 
Range on Protein: 1377-1569
Range on HMM: 2-144/152.0
LSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWrdsdvvqfgeyfikvefskecngyierkfhirsdkdesswdviQLQ
..||. ...||..| |..||. |||.|. ......||||. |.|.|.. |.||.                                           | .
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

VTDWPQDGVVREPRTVLQVIDDVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIGLeqckaeGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
 . || .||   .  .|.... . .. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .|.
hlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1316-1575 1.6e-27 91.3 In-house 13-278 (307) alignment 
Range on Protein: 1316-1575
Range on HMM: 13-278/307.0
TGCSGLQSQFELLSQVTPdpDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKE---NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAI
 | . |. .|. |.. ||  . |  .. .| .|||| .    |..  . .|       || | ||    . | || || |.|||  .|| |... || ..
kgvqalvdefrvlakktp..egvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLCGLEEDGEESCYQYWRD--SDVVQFGEYFIKVEFSKECNGYIE------RKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQ
.||| . | ..  | |||     .   |||    .  ..   . .           .. |  . |  . .|| ..||. || .   | . ... |   . 
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn

kigggPVVVHCSDTVSRSGVYCSVSIGLEQ-CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDK-FL
     |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. |  ||  .. |. . ||
.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1096-1283 1.1e-26 88.2 In-house 4-197 (199) alignment 
Range on Protein: 1096-1283
Range on HMM: 4-197/199.0
RTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSND-SHTLTQYHLT
. ..||.| |.. |. |||...|.     |||| . .   ..    ||| .     ..| ..||     . ||..|  | .     .   .  ...| .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDYAT--PLMSLHKQVMATWSPSK-GPILVHCSAGVGRTGTFIAIDIALEQ--AKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLH
|| ..  |. |    ..   ..|   .   |  |..|||| | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1097-1283 1.3e-26 88.0 In-house 4-196 (198) alignment 
Range on Protein: 1097-1283
Range on HMM: 4-196/198.0
TKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVKIYNGSND-SHTLTQYHLTS
 ..||.| |.. || |||...|.     |||| . .   ..    ||| .     ..| ..||     . ||..|  | .     .   .  ...| .||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDYAT--PLMSLHKQVMATWSPSK-GPILVHCSAGVGRTGTFIAIDIALEQ--AKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLH
| ..  |. |    ..   ..|   .   |  |..|||| | | || |.|.|| .      .  |||.  . .|||| |  .. .|..| |..
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
0049772 (Phosphotyrosine protein) phosphatases II 1344-1574 4.1e-26 87.9 In-house 44-279 (314) alignment 
Range on Protein: 1344-1574
Range on HMM: 44-279/314.0
KAHSDKNRSTSYLPQEnFLVTLK----ENNGYINASYLSGYrekKAFIIAQSPMENTARDF----------WKMIV--DYKVSAIVM-------------
 .. ||||..  || .  .| |.    .. .||||||..|.   ..||..| |.|.|  ||          |.|..  |..|  |||             
flnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------LCGLEEDGeescyQYWRDSDVVQFGeyfikvefskecngyierkfHIRSDKDESSWDVIQLQVTDWPQdGVVREPRTVLQVIdDVIHRQqkI
        |..| . |      ..  .|. ..                      .  |..  .  .|..  ...|  | .  .. ..... ..|..    
daAlgKtpllildgng.....neptaadlellk....................eelydpelferlgikylripvpD.gsaplledfdefl.efieea..d

GGGPVVVHCSDTVSRSGVYCSVSIGLEQCkaeGVvDVFQVTKAVRRSKP-----GAVTTLEQYTSIYDVIDKF
 ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .||||  |.... ..
kggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1079-1287 4.5e-26 86.6 In-house 43-256 (290) alignment 
Range on Protein: 1079-1287
Range on HMM: 43-256/290.0
KCQTTYTNASYIDgYSNRTKFIASQGPMKRT-------LVDFWRLIWQEKPVSIVMVTNLKEGTKS----KCEQYWPNSTGDNDHFGPFTVTLINEQVYP
. .  |  |...  ..|  ..|..| | ...       . .|| .. |||  ..||. . .| ..      |..| |.| |..  |. .||   .     
rfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskeked

DFVIRQLNVKiYnGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtwspSKGPILVHCSAGVGRTGTFIAIDIALEQAK-REGVVDIGGIVNRLR
|. .|.| || . . .  .|.| . | .| .  |..    |.|| ..|.|    || |..|||  |. |  .. ||...       .| | .  ... ||
dvetRelvvk.f.ddeeeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalr

QQRMKMVQTLDQYVFLHDAVL
.|| .....  .. |   ...
kqralaitsalelafvdagiv
0051082 (Phosphotyrosine protein) phosphatases II 1369-1571 8.3e-26 85.8 In-house 3-149 (151) alignment 
Range on Protein: 1369-1571
Range on HMM: 3-149/151.0
NGYINASYLSGYrekkaFIIAQSPMEntarDFWKMIVDYKVSAIVMLCGLEEDGeeSCYQYWRDSDvvqfgeyfikvefskecngyierkfhirsdkdes
..|||.||. |.     ... . |..    ||.... ......||.|...|| |   |..|... .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaegvVDVFQVTKAVRRSKPGAVTTLEQYTSIY
  .|......|||  |.   . .||.... ...     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  ..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DVI
 ..
fal
0048179 (Phosphotyrosine protein) phosphatases II 1172-1284 2.2e-25 84.5 In-house 47-139 (144) alignment 
Range on Protein: 1172-1284
Range on HMM: 47-139/144.0
RQlnvkiyngsndshtLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSpSKGPILVHCSAGVGRTGTFIAIDIALeqakREGvVDIGGIVNRLRQQRMK
|.               .||. ..||||||||... | .. . . .  . ..||.|||||||||||||..|... .    ..| ...  .....|..|. 
re..............giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpg

MVQTLDQYVFLHD
.|.. .|. ||..
avpnpgqlrfLle
subfamily_CG42327_pd Subfamily CG42327 1055-1218 2.9e-25 83.6 In-house 31-193 (319) alignment 
Range on Protein: 1055-1218
Range on HMM: 31-193/319.0
YNRFRNITPYDDNRIVLTPWPqlDKCQTTYTNASYIDGYSN-RTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDND--
 .|. |. |  . |.||   .  |. .. | .|||. || . .. .||.| ... .  ||||..|. .   || .|.| |    .| .|.| . . ..  
ksrvinvvPlPetrvvlqrig..dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

HFGPFTVTLINEQVYPDFVIRQLNVKIYNGSnDSHTLTQYHLtSWPDHGVPDYATPLMSLHKQVMAT
 .| . ||| . .|   ..|  | .|  ...  |  || |    |.. .||   ..|...  .| ..
lyGdilvtlkgrevkdryaistlllkrvdke.esrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1050-1287 1.8e-24 80.7 In-house 49-282 (302) alignment 
Range on Protein: 1050-1287
Range on HMM: 49-282/302.0
QENKVYNRFRNITPYDDNRIVLTpwpqldKCQTTYTNASYIDGYSNRTKFIASQGPMKRTL---VDFWRLIWQEKPVSIVMVTNLKEGTKsKCEQYWPNS
..|  .|.  ..  .|.|.. |.      ...  | ||| ..  . . . | .| | . .     .|||...||| ||.|..   .| .|   ....|. 
kknlkknqsedvpildsnlvkle......aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

TGDNDHFGPFTVTLINEQVYPDFViRQLNVKIY-NGSNDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDI
.||  ..| . |     .   . .  .. . .  .|  .|   . |.|| |... ||.  . |.   ..| |  .... ....    |.|| |.|..  .
sgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlav

ALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVL
|.|. ...  . |  ||. .|.|| ..|..|.|||.|. |.|
aveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1360-1575 1.9e-24 81.0 In-house 62-287 (305) alignment 
Range on Protein: 1360-1575
Range on HMM: 62-287/305.0
NFLVTLK--ENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYW--RDSDVVQFGEYFIK----------V
|  | |.      || | |.|   . | || .|.|.|.|  ||| | .. || || ||| | | | . |..|.  .| ||..| |   |          .
nnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtl

EFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQKiggGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV-DVF
.| |...  ...   .     |..  | .    |||. ||     ..|... .   |  |   ||.|||||  . |.|    .   |.|  |  .. |  
kfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka..rpsk...gpivvhcsagigrtgsvvmleyildqllagqiiedtd

QVTKAVRRSKPGAVTTLEQYTSIYDVIDKFL
.. . .|  .  .. | .||  ...|| ...
kilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1091-1291 2.1e-24 80.5 In-house 84-289 (302) alignment 
Range on Protein: 1091-1291
Range on HMM: 84-289/302.0
DGYSNRTKFI-ASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQ-VYPDFVIRQ----LNVKIYNGS--
||  .. |       | | ||  .| || | .   .| .....|. . || .|. .  |.. .|| .||. .. .    .|  ..     .|.| |    
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

-NDSHTLTQYHLTSWPDHGVPDYATPLMSLHKQVMAtWspsKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVF
 .  .|.   . ..||||| |. | . . . |   . .   |  .|||||||||||||..||   ..  ... | |.  ||  .|| |   ||. .| ..
kkvkktvdilafsawpdhGapkeaytaldilkfces.y...kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

LHDAVLETVM
|   |  ..|
lllcvtkglm
PTPc_DSPc_SM00012 1472-1571 1e-23 78.9 In-house 2-103 (105) alignment 
Range on Protein: 1472-1571
Range on HMM: 2-103/105.0
VIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYD
| ....|.||. || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..| |.|...| . ||.||. |..|...||.|.|.|||  .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1340-1571 1.1e-22 75.3 In-house 26-291 (297) alignment 
Range on Protein: 1340-1571
Range on HMM: 26-291/297.0
CDSAKAHS-DKNRSTSYLPQENFLVTLKE---NNGYINASYLSGYREKK--AFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDS
  . .  |  ||| .  |  ..  | |.    .. |||| |.    |..   .|.|| |...|  |||.....  | .|||.. |.||| . |. || ..
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

DVVQFGEYFIKVEF-SKECNGYIERKF-HIRSDKDESSWDVIQLQVTDWPQDGVV-------RE----------PRTVLQVID---DVI------HRQQK
.  .     . ||| |.  . .   ..  ..    . |  |   |   ||. ||        |              .| ...    ..       | ..
vqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraem

IGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
    ...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||||.. .||..
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1362-1574 1.7e-22 74.4 In-house 59-268 (281) alignment 
Range on Protein: 1362-1574
Range on HMM: 59-268/281.0
LVTLKENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWR-DSD-VVQFGEYFIKVEFSKECNGYIERKF
 .  |.   || | |.     |. .|..| | ..|  |||.|| . . .|||||| . |   | | .|.  ..  ..|| .. .. | |   .  .  ..
kmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrl

HIRSDkDESSwDVIQLQVTDWPQDGVVREPRTVLQVIddvihRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRS-KPGA
 .  .  |.   . .    .||.  |      .|...     |. .    | |.|||  | |||   .| | |.  ..   . |. |.   .| . .  .
nlsye.getr.lithwlwkewpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraas

VTTLEQYTSIYDVIDKF
| ||.||  |. |.  |
vqtlqqymliwkvlldf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1368-1571 1.8e-22 74.8 In-house 45-255 (290) alignment 
Range on Protein: 1368-1571
Range on HMM: 45-255/290.0
NNGYINASYLSgYREKKAFIIAQSPMENT-------ARDFWKMIVDYKVSAIVMLCGLEEDGEE----SCYQYWRDSD--VVQFGEYFIKVEFSKECNGY
|..|| |.... . .  ..|. ||| |..         .|| |. . ||  .||||  ||  ..    .| .| ..|    ..|.   .|     . .. 
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

IERKFHIRSDkDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIGLEQCK-AEGVVDVFQVTKAVRRS
..|.  .. | ||  . |   .. .| .  | ....|.|..|. |  ..      ||.||| | .||| .  .. .|       .| | . .| ||.|. 
etRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkq

KPGAVTTLEQYTSIYDVI
.  |.|. .... .  .|
ralaitsalelafvdagi
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1340-1563 6.5e-22 72.6 In-house 44-269 (301) alignment 
Range on Protein: 1340-1563
Range on HMM: 44-269/301.0
CDSAKAHSDKNRSTSY--LPQENFLVTLKENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYW--RDSDV
   |  . ||.|  .    |.    |  . .   | | ...   . . ||..|.|..||. ||| |.| |.|  ||||.   |. || | .|   . |. 
esyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

VQFGEYFIKVEFSKEC--NGYIERKFHIRSD-KDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDdVIHRQQKigggPVVVHCSDTVSRSGVYCSVSIGL
.. | . ||.. ..    .  ..|.....   .. ..  |.  | ..|.. || .    . .... .. . .|    |.|||||. . ||  . .  .  
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkksek....PivvhcsaGiGrsvafigteyla

EQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQ
 . .|.  ... .  | .|  .  .| | .|
reveadptieltealkhlrehrwngvqtnsq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1343-1574 1.2e-21 71.9 In-house 32-269 (285) alignment 
Range on Protein: 1343-1574
Range on HMM: 32-269/285.0
AKAHSDKNRSTSYLPQENFLVTLKEN-NGYINASYLS-GYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRD--SDVVQF
 .|  | || .     |.  | ||.    || ||..    ... ..| .| |. .|  |||.|| . |.. ..||| | | | | |  |. .   .||.|
yeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

GEYFIKVEFSKE--CNGYIERKFHIRSDKDESSWDV--IQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSIGLEQ
|.| | .   ||    | |   . .   .| ||  .   ..||  ||..    . | ....   | . . |    |..||||  | |.  .  .     .
gkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatir

CKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKF
   .  ...... . .|  .  || .  |.  .| |. ..
imenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1369-1577 1.8e-21 71.4 In-house 67-273 (288) alignment 
Range on Protein: 1369-1577
Range on HMM: 67-273/288.0
NGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWR--DSDVVQFGEYfikVEFSKECNGYIERKFHI---RS
. ||.|  .|  . |. .| ||.|.. |   .|||...  |  ||||| | | | |   .|.     . ...| .       |. .  |..  ..   | 
dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl...ctvvkkkradidklvkvsllri

DKDESSWD-VIQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLE
 |       | .| . .|..|||  .  . |.... . .  ||    |.|||.|  | |.|    . | ||. . .  . . .. .  | ..  |..|  
skegeekvivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtem

QYTSIYDVIDKFLAI
||  .. .. . |..
qylyvhrcvleelll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1109-1310 2.8e-21 70.8 In-house 40-235 (255) alignment 
Range on Protein: 1109-1310
Range on HMM: 40-235/255.0
TLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINeqVYPDFVIRQLNVKIYNG-SNDSHTLTQYHLTSWPDHGVPDYATP
|.  |.. | | |.  .||.....| .. ||..|.|    .   .   .||  .     | |.| |..  . |     ||.. |. . |...  |. |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LMSLHKQVMAtwspSkGPILVHCSAGVGRTGTFIAIDIALE------QAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVmcgdteIPSNE
.. . | |      |  ...||||.|.||. .|. ....        .    . .|   ... ||..| . ..|  |  |    ||. |       | .|
ilnilkvvrd....s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv......fpkge

YEMKLRELK
.| |. |..
leakyqeir
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1341-1573 3.9e-21 70.0 In-house 50-287 (305) alignment 
Range on Protein: 1341-1573
Range on HMM: 50-287/305.0
DSAKAHSDKNRSTSYLPQENFLVTLKEN--NGYINASYLSG-YREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDS----
.||.    ||| .    |.. .| |..     || | |.      .| || || |...|  .|| |... ||  |||||   | |   | |||  .    
qsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

DVVQFGEYFIKVEFSKECNGYIERKFHIR--SDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIG
  .. |    .|  ||  .   | .  .   .   . .  | .|| |.||. ||     | |...  .  |  |.   |.|||||  . |.|   ..   
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyi

LEQCKA-EGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDK
||.      .  . .. ||.|  .  .. .  ||  |. |. .
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1389-1573 1.5e-20 67.8 In-house 96-286 (302) alignment 
Range on Protein: 1389-1573
Range on HMM: 96-286/302.0
AQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRD--SDVVQFGEYFIK-VEFSKECNGYIERK--------FHIRSDKDESSWDVIQLQV
   |  .|   .| .| .|.|. .| ||.. ||.|. | .|. |   ....||.| .| |.  .. . . ..|        ..    |..    |  |. 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TDWPQDGVVREPRTVLQVIDDVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDK
. ||. |  .|. | |...      ...     |.||||  | |.|   ..  |.. |. . | |. .. . ||. . ||| . .| . .  .. |
sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtk
0044763 (Phosphotyrosine protein) phosphatases II 1368-1577 1.6e-20 68.9 In-house 17-173 (178) alignment 
Range on Protein: 1368-1577
Range on HMM: 17-173/178.0
NNGYINASYLSGYrekkaFIIAQSPMentaRDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVvqfgeyfikvefskecngyierkfhirsdkde
   |||||.  ..     ..... |.     |..... ......||.|..  | | ..|..|| ..                                  
rsdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................

sswdvIQLQVTDWPQDGVVREPRTVLQVIdDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQckaeGVvDVFQVTKAVRRSKPgAVTTLEQYTSI
     || . . .| .||   .. .|... . |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .|.  .
.....iqylhipipDhgvpdllehflefv.efieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqL

YDVIDKFLAI
|..  ..|. 
yefelrllke
subfamily_ptpA1_pd Subfamily ptpA1 1324-1532 4.3e-20 66.8 In-house 26-253 (418) alignment 
Range on Protein: 1324-1532
Range on HMM: 26-253/418.0
QFELLSQVTpDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLK-----ENNGYINASYLSGYREkKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGL
.| || .    | .      |  . ||| |  || .   | ||     | . |||| |. |    | || .| |. ||  |||.|. . ..  ||||   
efrlleesv.gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsre

EEDGEESCYQYWRDS-DVVQF----------GEYFIK-VEFSKECNGYIERKfHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKI
 |.    | .|| .     ||          | | .. ||  .. .  |  .  ||   .  . |. | |   ||.  .    . . |..  .  ||..|
sencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitr.nirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqi

G-----GGPVVVHCSDTVSRSGVYCSVSIGL
        |..||||  | |.| .|.  | .
ipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1317-1571 3.7e-19 63.4 In-house 25-286 (310) alignment 
Range on Protein: 1317-1571
Range on HMM: 25-286/310.0
GCSGLQSQFELLSqVTPDPDDVFcDSAKAHSDKNRSTSYLPQENFLVTLKE----NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAI
|  ||  |.  |     |.   . .. | .  ||| .  . ...  | ||      . || | |.     ...|| .| |.. |  |||.|| . .  .|
gieglvkqyrkld.akqdsslty.eaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesi

VMLCGLEEDGEESCYQYWRDSDVVQFGEyFIKV-EFSKECNGYIERKF-------HIRSDKDESSWDVIQLQVT---DWPQDGVVREprtVLQVIDDVIH
..||   |.|   |  ||    | .     |.| ..|.  . .   ..        .  |.. .  . .....    .||. ||  |     . . . . 
lllckvgeegrpkcvgywpslgvtetyg.cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde...kchtvpqrll

RQqkIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
 |  .  ||.|||||  . | .| ... . ... .    ||. .|   ...|.   . |  ||. |  | 
aq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1331-1486 1e-18 61.8 In-house 81-236 (244) alignment 
Range on Protein: 1331-1486
Range on HMM: 81-236/244.0
VTPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLKE---NNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEescy
. |||  .        | |||  . || .   | | .    | |||||..        .|..| |. .|. |||||... .|  .|.|  .||. |    
irpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede....

qYWRDSDVVQFGEYFIKVEFSK--ECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVV
 || ||. ... |  | | ..   |       .. | || .||   .  .|...|| ||  
.ywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgtt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1052-1185 1.2e-18 62.0 In-house 47-191 (350) alignment 
Range on Protein: 1052-1185
Range on HMM: 47-191/350.0
NKVYNRFRNITPYDDNRIVLTPWPQLDK-----CQ-TTYTNASYIDGY----SNRTKF--IASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
    ||..|| ||. .|. |   ..  .     ..   | ||.|.       .  ..|  || |.|...|. ||...| . |   |...|.. |    ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

EQYWPNSTGDNDHFgPFTVTLINEQVYPDFVIRQLNVKIYNGSNDS
..||.. . |. .   .. .  |     | ...  .||.    || 
yrYWqegsydditv.klaskwenimgindsslysadvkkeasdndn
subfamily_egg_pd Subfamily egg 1370-1575 1.5e-18 61.5 In-house 69-270 (307) alignment 
Range on Protein: 1370-1575
Range on HMM: 69-270/307.0
GYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDgeESCYQYWR--DSDVVQF--GEYFIKVEFSKECNGYIERKFH---IR
 .| | ...|      ||.||.|. ||  |||.|.   .|  ||||    |   | |  ||   .|| ...  | . |.    ..    . |  .   . 
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvG

SDKDESSwdvIQLQVTDWPQDGVVREPRTVLQVIddvihRQQkigGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVV--DVFQVTKAVRRSKPGAVTT
.|..|     ..    |. . . |  |  ||. .     |.      ||||.. . ||....  .. | | .     ..   | .  . .|. .. .| .
gddeerf...lehwqgdvnnssdvysplrvlrkl.....rnl...skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsves

LEQYTSIYDVIDKFL
  .|  .| ..  |.
vllylfvyrlvlfff
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1308-1574 3e-18 60.3 In-house 16-284 (302) alignment 
Range on Protein: 1308-1574
Range on HMM: 16-284/302.0
ELKEIDSsTGCSGLQSQFELLSQVTPDPDDvfCDSAKAHSDKNRSTSYLPQENFLVTLK-ENNGYINASYLSGYREKKAFIIAQSPMENTA---RDFWKM
..| ..|    . ....|. ....  | .   | . |....||.|. .   .. || |. |.. |.||| ..    ..  |.|| |  ...    .||.|
akklvks.ldtaevkkefkkidtmkvdlek..CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrm

IVDYKVSAIVMLCGLEEDGEeSCYQYWR--DSDVVQFGEYFIKVEFSKECNGYIeRKFHIR---SDKDESSWDVIQLqVTDWPQDGVVREPRTVLQVIDD
. . |.  .|.| | ||  . .  ...     | ...|. |. .   .. ..    .. |     .  .|    ... .| |.|. |  .  .. . . .
vfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyv.ltnWkqkkvpvkyaeliktaak

ViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKF
| . ..  .  ..|.     . | |.  .. . .|. ...  . . .. |..|  .| || .|.||.|.| ..  .
v.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1366-1581 3.6e-18 60.3 In-house 64-282 (312) alignment 
Range on Protein: 1366-1581
Range on HMM: 64-282/312.0
KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDS-------DVVQFGEYFIKVEFSKECNGYIER-
 ..| || | ..      . |...|.|.|||.  ||.. .    ..|..|||. ||| | | .|  |        |   . ||  ..|     .  |   
gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithr

--KFHIRSDKDESSWDviQLQVTDWPQDGVVREPRTVLQVIDDViHRQQKigggPVVVHCSDTVSRSGVYC---SVSIGLEQCKAEGVVDVFQVtkaVRR
  |  ...  .||  .  . | . ||. |.     | |...  | ....|    ||. |||  | |.|  .   |.   | . . . | |.| .   .|.
vlkvvvkatgqeskln..hyqwaswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrk

SKPGAVTTLEQYTSIYDVIDKFLAINSTY
 .  .| .. ||     .. .||  .. |
drarsvrvfpqyvyalrcvleflyskgly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1216-1290 9.5e-18 59.1 In-house 221-295 (297) alignment 
Range on Protein: 1216-1290
Range on HMM: 221-295/297.0
MATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETV
. .  | . ..||||||||||.|  .  |. |.. ... . |.  |.. ||.|| ..||||.|. .|.||||. .
lraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1224-1287 4.1e-17 56.9 In-house 263-341 (350) alignment 
Range on Protein: 1224-1287
Range on HMM: 263-341/350.0
GPILVHCSAGVGRTGTFIAIDIALE------Q-AKRE-------GVV-DIGGIVNRLRQQRMKMVQTLDQYVFLHDAVL
 |||||||||||||||....|  |.      .  |.         .   |  |||.||.||..|||.|||..|...|.|
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_hpo-7_pd Subfamily hpo-7 1108-1309 1.4e-16 55.2 In-house 45-243 (263) alignment 
Range on Protein: 1108-1309
Range on HMM: 45-243/263.0
RTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVypDFVIRQLNVKIYNG-SNDSHTLTQYHLTSWPDHGVPDYAT
.|.  |.. | | |.  .||... .|  . ||..|.|    .   .   .|.  . |   | ... |..  . |     ||...|  . |...  |  | 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

PLMSLHKQVmatwSPSKgPILVHCSAGVGRTGTFIAIDIALE------QAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMcgdTEIPSN
  . . | .      || .. ||||.|.||.  |  ....        .    . .|   ... ||..| . ..|  |  |    ||. |.    . . .
eilnilkva....rnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl...nnfakg

EYEMKLREL
| | | .|.
eleakyqei
subfamily_CG42327_pd Subfamily CG42327 1222-1285 1.5e-16 55.0 In-house 246-310 (319) alignment 
Range on Protein: 1222-1285
Range on HMM: 246-310/319.0
SKGPILVHCSAGVGRTGTFIAIDIALEQAKRE-GVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDA
|.||. |||| ||||||. || |||... .     |||  .|  .|..| . |.| .|| |..  
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1227-1293 3.1e-16 53.5 In-house 2-68 (69) alignment 
Range on Protein: 1227-1293
Range on HMM: 2-68/69.0
LVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCG
.||||.| ||||||||| . . . | | .|||   |. .|. |  ||    .|.|.|||. |..  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1320-1436 3.8e-16 53.7 In-house 21-156 (350) alignment 
Range on Protein: 1320-1436
Range on HMM: 21-156/350.0
GLQSQFELLSQVTPDPDDVFCDSAKAHSDKNRSTSYLPQENFLVTLK-------------ENNGYINASYLSGY----REKKAF--IIAQSPMENTARDF
  .|.. | |. . . .||   .      ||| .  || |   | ||             . | ||||.||.      . .  |  | .|.|. .|  ||
tvksrlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddf

WKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVV
.|.|.  ||  |..|  . | . | ||.||.. .. 
ykvillnkvkvilsltsdvelnlekcyrYWqegsyd
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1228-1293 4.9e-16 52.8 In-house 2-67 (69) alignment 
Range on Protein: 1228-1293
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVMCG
||||.| ||||||||| . . . | | .|||   |. .|. |  ||   ..|.|.|||. |..  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_CG42327_pd Subfamily CG42327 1364-1497 5e-16 53.3 In-house 46-188 (319) alignment 
Range on Protein: 1364-1497
Range on HMM: 46-188/319.0
TL-----KENNGYINASYLSGYREKKA-FIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVV----QFGEYFIKVEFSKECNG
.|     .... |..|||. ||.. .. .| || ..|... |||... . .   || |. | | | . | .|.  ..       .|.. . .   .  . 
vlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdr

YIERKFHIRSDKDESSWDVIQLQVtDWPQDGVVREPRTVLQVID
|.   . ..  ..| | ..      .|.. .|  |..... .. 
yaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamll
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1382-1570 6.5e-16 53.1 In-house 3-199 (199) alignment 
Range on Protein: 1382-1570
Range on HMM: 3-199/199.0
EKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWR--DSDVVQFGEYFIKVEFSKECNGYIERKFHIR--SDKDESSWDVIQLQV
 .. .| .| |. .|  |||.|. .     |||.   . . |     ||   .| . ..|   . ..       |    . .   .    |. .. . | 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TDWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
| | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1383-1570 7.3e-16 52.9 In-house 3-198 (198) alignment 
Range on Protein: 1383-1570
Range on HMM: 3-198/198.0
KKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWR--DSDVVQFGEYFIKVEFSKECNGYIERKFHIR--SDKDESSWDVIQLQVT
.. .| .| |. .|  |||.|. .     |||.   . . |     ||   .| . ..|   . ..       |    . .   .    |. .. . | |
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPQDGVVREPRTVLQVI--DDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIGLEQCK--AEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
 | .         |  |.   .| .. ..    ||.|||||    .||. .. ||.   .     |||.|.|.| .|... | ...|..|  ||.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1366-1486 7.8e-15 49.3 In-house 10-127 (130) alignment 
Range on Protein: 1366-1486
Range on HMM: 10-127/130.0
KENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEescyqYWRDSDVVQFGEYFIKVEFS-KECNGYIER-KFHIRS
 ..| |||||..      . .. .| |. .|. |||||...  |  .|.|  .||. |     || ||. ... |  | |  . ..   .|.  ...| |
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikasnleies

DKDESSWDVIQLQVTDWPQDGVV
|  ||   .  .|...|| ||  
dlneshqaltmfqisnwpsdgtt
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1346-1575 3.3e-14 47.2 In-house 47-279 (303) alignment 
Range on Protein: 1346-1575
Range on HMM: 47-279/303.0
HSDKNRSTSYLPQENFLVTLKEnNGYINASYLSGYREKKAfIIAQSPMENTARDFWKMIVDYKVSAIVMLC-GLEEDGEESCYQYWRDSDVVQFGEYFIK
  |||| .  .  .   | | .   || ||||    .||| |..| |.  || |||.||.. ||  ...|    | |     . . |. | ..| | .|.
nmdknrfvdvicldhskvklsd.ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersir

VEFSKEC---NGYIERKFHIrSDKDESSWDVIQlQVTDWPQDGVVRE--PRTVLQVIDDVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIG-LEQCKAE
|   |.    .|.  .   . |. |  |.  .. .  .||.. .  .  |. | |. .     ..   . | |      . |.| ..      |   . .
vgefkrvelgdgwvlkvlsv.sngdyksflhvh.hykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseq

GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFL
  .|. .. . ||  .  ||  | |.. .| .. . .
asldlvkclenvrngrlhavqnlsqfsvvytllaehv
0048076 (Phosphotyrosine protein) phosphatases II 1444-1572 5.6e-14 47.5 In-house 19-140 (145) alignment 
Range on Protein: 1444-1572
Range on HMM: 19-140/145.0
KVEFSKECNGYIERKFHIRSDKDESSWDVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiGLEQCKAEGvVDV
 ...   ..  | . . . |...  .  .||.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.|...    ..  .. .| |..
aldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsl

FQVTKAVRRSKPGAVTTLEQYTSIYDVID
... . ||.  ||||.. .|.  .|... 
eealelvrsqrpgavpnpgqlrflyefel
fn3 Fibronectin type III domain 612-701 2.6e-13 43.1 Pfam-A 1-85 (85) alignment 
Range on Protein: 612-701
Range on HMM: 1-85/85.0
SPVTSLSVSNVSTTGIRVNWTIP-SSDNYVTYYTISYTPSCPQLssvnE--EVSVTPHqsttTYSYTLTGLYSGMNYTITVRAGNVLGGSELS
|... ||||.|..| ....|. | . .  .|.|.. | ..  .     |  |..|...    |.|.|||||  |..|...|.| |  |... |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge....ewkeftvprt....ttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1045-1201 2.8e-13 44.0 In-house 89-235 (244) alignment 
Range on Protein: 1045-1201
Range on HMM: 89-235/244.0
VIGFSQENKVYNRFRNITPYDDNRIVLTPwpqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWqEKPVSIVMVTnlkeGTKSKCEQYWP
   |. .|   ||     |.| ||. |.          || |||..      ...| .| |.  | .|||...  |. | ...|     |.  . ..|||
kdafnpnnswknregaglpfdfnrvplsk....gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvl....gsveeedeywp

NSTGDNDHFGPFTVTLINEQVYPDfvIRQLNVKIYNGSNDSH-TLTQYHLTSWPDHGV
.|   . .    |||| . . . .  |.  |..|    |.|| .|| . .. ||  | 
dseplewyeeditvtltdrdefkn..ikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1008-1104 3e-13 43.7 In-house 4-95 (95) alignment 
Range on Protein: 1008-1104
Range on HMM: 4-95/95.0
PIALEDLGTHVANCHTDNNTLFGEQYKAIYNGEDKSTVIGFSQENKVYNRFRNITPYDDNRIVLTpwpqlDKCQTTYTNASYIDGYSNRTKFIASQG
|| .  . .|| . |.. .  | ...|.|      .  .| |. |   ||| || |||  |.|||      | .. | || ..|||. .  .||.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt.....tkrdsdyinacfvdgyarkncyiaaqg
fn3 Fibronectin type III domain 341-415 9.9e-13 41.2 Pfam-A 2-79 (85) alignment 
Range on Protein: 341-415
Range on HMM: 2-79/85.0
APSSLTEVNQTATTMTVGWTALD--SSDADGYVVNVTSDTDT--VQTLQVEGSSNnTITLNGLREETTYNITVRAYQQL
||. |.  ..|.|..|. |.. .  ... .|| | . .....   .. .|..... . ||.||.. |.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
0048179 (Phosphotyrosine protein) phosphatases II 1459-1569 1.3e-12 43.2 In-house 48-139 (144) alignment 
Range on Protein: 1459-1569
Range on HMM: 48-139/144.0
FhirsdkdesswdVIQLQVTDWPQDGVVREPRTVLQVIDDVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSigleQCKAEGvVDVFQVTKAVRRSKPGAV
.            .||.. ..||  ||   .  .|.... . . ..   ||||.||||  |.|.|...        .| .| ...... . ||.  ||||
e............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgav

TTLEQYTSIYD
.. .|.  ...
pnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1091-1175 1.5e-12 41.6 In-house 230-310 (440) alignment 
Range on Protein: 1091-1175
Range on HMM: 230-310/440.0
DGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTkskCEQYWPNSTGDnDHFGPFTVTLINEQVYPDFVIRQLN
.|||..  |||.| |.  |..|||||. . .  .|.|. .|.. |   |  |||  |     ||||||     .      .| |.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrs.vtfgpftvghkgsenmnrvkvrtle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1224-1288 2.8e-12 40.6 In-house 266-342 (349) alignment 
Range on Protein: 1224-1288
Range on HMM: 266-342/349.0
GPILVHCSAGVGRTGTFIAIDIALE--QAKREGVV----------DIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLE
 ..||||||| ||||... .|. |.  .  ..  .           |  ||| ||.||. ||| | |......|.|.
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1056-1291 4.2e-12 40.3 In-house 51-280 (303) alignment 
Range on Protein: 1056-1291
Range on HMM: 51-280/303.0
NRFRNITPYDDNRIVLTpwpqldkcQTTYTNASYIDGYSNrTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNstgdNDHFGP
||| ..   |  .. |.        ...|  |||..  |.  | | .| |.  |  |||..| ..|   ....    |  |   .  .|.    |. |  
nrfvdvicldhskvkls........dssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr....nqdflk

FTVTLINEQVYPDFV-IRQLNVKIYNGSNDSH--TLTQYHLTSWPDHGVPDYATPLMSL----HKQVMATWSPSKGPILVHCSaGVGRTGTFIAIDIALE
|    |    .         ..|.   || ..   |  .|  .||   .|  ..| .       . |.  .|.|. .. .  | |.||.|||  .. |  
feersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls.gcgragtfalfetahl

-QAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM
   . .  .|.   .. .|. |.. || | |. ...  . | |.
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
fn3 Fibronectin type III domain 715-795 5.4e-12 38.9 Pfam-A 2-85 (85) alignment 
Range on Protein: 715-795
Range on HMM: 2-85/85.0
QPLSIRVLPVNSTANRFTWNEVNcsERNGLITGYTVIISNS-----SITYNLTSTERYIILNDLVFGTEYNISVAAVNSVGRGPFS
.|  ..| .|.||  ...|.. .  ...| ||||.|  ...     . ......|..  .|..|  ||||...|.||| .| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_eak_pd Subfamily eak 1052-1213 7.8e-12 39.2 In-house 52-205 (332) alignment 
Range on Protein: 1052-1213
Range on HMM: 52-205/332.0
NKVYNrFRNITPYDDNRIVLTPWpqlDKCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKCEQYWPNSTGDND
.   |   .| ||| . . ||.     . .  | ||| ..      |.| .  . .  .  ||... ..|  .||.. .  |    | ..|.|. | .. 
avnrn.vvkivpydrylvrltss...qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

HFGPFTVTLINEQVYPDFVIRQLNVKIyngSNDSHTLTQYHLTSWPDHGVPDYATpLMSLHK
.|| . |.  .      .  |.| ..     |..| .  |..  | .  .| |   ...|.|
kfGildverkefvkrniletrllelsk...GnethrvlhykvfGwtettlpkyed.flalrk
fn3 Fibronectin type III domain 109-183 9.1e-12 38.2 Pfam-A 2-79 (85) alignment 
Range on Protein: 109-183
Range on HMM: 2-79/85.0
APSPLTEVNKTATTITVNWTGL--NSSDADGYVVNVTSDTDT--VQTVQVEGSSNnTITVNGLRELTTYSITVRAYQQL
||. |.  . |.|..|..|.    .... .|| | . .....   ....|..... . |..||.. |.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_CG42327_pd Subfamily CG42327 1507-1575 1.9e-11 38.2 In-house 246-315 (319) alignment 
Range on Protein: 1507-1575
Range on HMM: 246-315/319.0
GGGPVVVHCSDTVSRSGVYCSVSIGLEQCKAE-GVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVIDKFL
  ||.|||||| | |.|.  .  | ... .     ||. |.   ||| .  || | |||  || |. .. 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1368-1447 5.3e-11 36.4 In-house 89-167 (349) alignment 
Range on Protein: 1368-1447
Range on HMM: 89-167/349.0
NNGYINASYLSGY--REKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDvvqFGEYFIKVEF
 . |||| ||.      .| .|  | |.  |  ||.|.|.  .|  .. |   .| . | |..||.. .   . .. .|.  
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels...ysnitvklqn
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1052-1152 1.7e-10 34.7 In-house 48-162 (349) alignment 
Range on Protein: 1052-1152
Range on HMM: 48-162/349.0
NKVYNRFRNITPYDDNRIVLTPWPQLDKCQ------------TTYTNASYID--GYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVTNLKEGTKS
    ||...| ||.  |..|   ..  |                | || |.    .|   |.|| | |.  |. ||...|  ..   .. ... || .  
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCEQYWPNSTGDNDH
||..|| . . .| .
kcdiywqelsysnit
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1388-1560 1.9e-09 32.0 In-house 39-206 (255) alignment 
Range on Protein: 1388-1560
Range on HMM: 39-206/255.0
IaqspmenTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDVVQFGEYFIKVEFSKECNGYIERKFHIRSDKD--ESSWDVIQLQVTDWPQDGV
.       |   |...||  | . .|||| ..|.| | | .|.      .     ..|  .|  .  . |  .| |         .|   . . |..   
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

VREPRTVLQVIDDVihRQQKigggPVVVHCSDTVSRSGVYCSVSI-------GLEQCKAeGVVDVFQVTKAVRRSKPGAVTT
 ...| .|...  |  |. |    .||||||  . ||  .  . .        |.. .. . .|  .. . .| ....|. |
Pelareilnilkvv..rdsk....svvvhCstGiGrsaafvlaelvyqkmirsldttet.veldylslleelrskrkraiht
subfamily_eak_pd Subfamily eak 1357-1464 2.3e-09 31.1 In-house 62-175 (332) alignment 
Range on Protein: 1357-1464
Range on HMM: 62-175/332.0
PQENFLV----TLKENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDS--DVVQFGEYFIKV-EFsK
|.. .||    . ....|||||| .      . .|..  . |.    ||.|... |  |||.|    | . |   .|. |   ....|| . ..  ||  
pydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef.v

ECNGYIERKFHIRSD
. | .  |.. ..  
krniletrllelskG
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1364-1416 3.1e-09 30.8 In-house 65-117 (347) alignment 
Range on Protein: 1364-1416
Range on HMM: 65-117/347.0
TLKENNGYINASYLSGYREKKAFIIAQSPMENTARDFWKMIVDYKVSAIVMLC
   . ..|||||..     .| .|..| |. .| ||||||.   ||. .| . 
raddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
0038934 (Phosphotyrosine protein) phosphatases II 1170-1243 6.9e-09 31.1 In-house 49-135 (194) alignment 
Range on Protein: 1170-1243
Range on HMM: 49-135/194.0
VIRQLNVKIYNGSNDSHTLTQYHLTSWPDHGV-------------PDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAI
....||||..   . ..| . |. . ....|.             |.... |  |.     .   ..| ..||| ||.|||||..| 
ylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1052-1139 9.8e-09 29.1 In-house 34-118 (332) alignment 
Range on Protein: 1052-1139
Range on HMM: 34-118/332.0
NKVYNRFRNITPYDDNRIVLTPwpQldKCQTTYTNASYIDGYSNRTKFIASQGPMK-RTLVDFWRLIWQEKPVSIVMVTNLKEGTKSKC
|   ||   .  .| .|. |.|  |    .  . |||..||||... .| .| |.. .|   |||.. . ||  |... .. |  | |.
nmdmnriphlycfdhsrvelap..q..dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
fn3 Fibronectin type III domain 527-593 2.5e-08 27.1 Pfam-A 2-76 (85) alignment 
Range on Protein: 527-593
Range on HMM: 2-76/85.0
PPNNVTGFIIKPTSIKVNWTTS----SETNGYVIEYTTGGVT--RNVISTSEDE--IVLTDLSPMSTYTISVYSY
.| |..   . .||. ..|. .    ..  || .|| . | .   . .......   .||.| | ..|...|...
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav
PTEN_1 1178-1242 2.7e-08 28.8 In-house 84-149 (196) alignment 
Range on Protein: 1178-1242
Range on HMM: 84-149/196.0
IYNGSNDSHTLTQYHLTSWPDHGVPDYATpLMSLHKQVMATWS--PSKGPILVHCSAGVGRTGTFIA
 |. .   .   .|.  ...|||.|. .  |.   |...  ..  |... .|||| ||.||.|| .|
sydleeffksgveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_hpo-7_pd Subfamily hpo-7 1394-1572 2.7e-08 28.1 In-house 44-225 (263) alignment 
Range on Protein: 1394-1572
Range on HMM: 44-225/263.0
ENTARDFWKMIVDYKVSAIVMLCGLEEDGEESCYQYWRDSDV--VQFGEyfIKVEFSKECNGYIERKFHIRS--DKDESSWDVIQLQVTDWPQDGVVREP
 .|   |...||  | . .||||  .|.| | | .|.        .. .  ..|  .|  .  . .  .. |  ..     .| . . . |..   ....
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan..vnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

RTVLQVIDdvIHRQQKigggPVVVHCSDTVSRSGVYCSVSIGL-------EQCKaEGVVDVFQVTKAVRRSKPGAVTTLEQY-TSIYDVID
| .|....  . |. |    ..|||||  . ||  .  . .         .. .  . .|  .. . .| |...|. |  |   ||. |.|
reilnilk..varnsk....slvvhcstGiGrsaafsvaElvyqkmirsldtts.tveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_PTPDC1_pd Subfamily PTPDC1 1190-1284 3.9e-08 28.0 In-house 84-170 (182) alignment 
Range on Protein: 1190-1284
Range on HMM: 84-170/182.0
QYHLTSWPDHGVPDYATpLMSLHKqVMaTWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAkregvVDIGGIVNRLRQQRMKMVQTLDQYVFLHD
 ..  .|.|.||.   . .. . | |. . . ..| . ||| || ||||  ||  .   .      ..    .. .|..| | .|| .|  ....
yvynfgwkDygvasler.iLdivk.vv.afalqegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1109-1319 4.2e-08 26.2 In-house 130-339 (346) alignment 
Range on Protein: 1109-1319
Range on HMM: 130-339/346.0
TLVDFWRLIWQEKpVSIVMVTNLKEGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDFVIRQLNVkIYNGSNDSHTLTQYHLTSWPDHGVPDYATPL
 . ||| .|.||. . .| .    .  |      . .  |  .. | . .     .|  |     ..| . .|  ||     .| . |     |  . |.
fvedfwymiyqeq.ihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytiev.lpegnsdsvicqvhhhapwkhlqqppktlpi

MSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAIDIALEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM--CGDTEIPSNEYEM-K
. . .| ..     .  . |    | ||. .||    |..|       .|  |.  ..|||   |... ||  ..  |.. .    |  . | | .    
ikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggkkapvnkdinrf

LRELKEIdsSTGCS
. || ||  |  ||
idelaei..spacs
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1070-1201 1e-07 26.3 In-house 11-126 (130) alignment 
Range on Protein: 1070-1201
Range on HMM: 11-126/130.0
VltpwpqldkcQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWqEKPVSIVMVTnlkeGTKSKCEQYWPNSTGDNDHFGPFTVTLINEQVYPDf
           . || |||..    . .... .| |.  | .|||...  |. | ...|     |.  . ..|||.|   . .    .||| . . .   
q..........gntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvl....gsveeedeywpdsePlewyeediivtltdrdefkn.

vIRQLNVKIYNGSNDSH-TLTQYHLTSWPDHGV
 |.  |..| .  |.|| .|| .... ||  | 
.ikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1051-1129 1.8e-07 25.0 In-house 36-117 (347) alignment 
Range on Protein: 1051-1129
Range on HMM: 36-117/347.0
ENKVYNRFRNITPYDDNRIVLTPWPQL-D--KCQTTYTNASYIDGYSNRTKFIASQGPMKRTLVDFWRLIWQEKPVSIVMVT
 .   || ..    |. |.||.|            || |||.|     ....| .| |.  |. |||...   |   .| . 
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1368-1425 2.5e-07 24.5 In-house 59-117 (332) alignment 
Range on Protein: 1368-1425
Range on HMM: 59-117/332.0
NNGYINASYLSGYREKKAFIIAQSPMEN-TARDFWKMIVDYKVSAIVMLCGLEEDGEES
.. . |||.. || .| |.|.||.|... |   ||.|. . | | |...  ..|  .  
kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1512-1571 3e-07 24.7 In-house 2-61 (69) alignment 
Range on Protein: 1512-1571
Range on HMM: 2-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVI
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.| .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_CDC14_pd Subfamily CDC14 1174-1243 7.2e-07 23.3 In-house 219-283 (328) alignment 
Range on Protein: 1174-1243
Range on HMM: 219-283/328.0
LNVKIYNGSNDSHTLTQYHltswpDHGVPDYATPLMSLHKQVMATWSPSKGPILVHCSAGVGRTGTFIAI
|| |.|. ..  ..  ...     |    | .||  .. |. ..    ..| | ||| ||.|||||.|| 
LnkklYdakkftdaGfdhk.....DlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1512-1572 1.1e-06 22.8 In-house 1-61 (69) alignment 
Range on Protein: 1512-1572
Range on HMM: 1-61/69.0
VVHCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDVID
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.| . 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_eak_pd Subfamily eak 1212-1291 2.4e-06 21.2 In-house 227-306 (332) alignment 
Range on Protein: 1212-1291
Range on HMM: 227-306/332.0
HKQVMATwSPSKGPIlVHCSAGVGRTGTFIAIDIA--LEQAKREGVVDIGGIVNRLRQQRMKMVQTLDQYVFLHDAVLETVM
 |. . |  ||  || . .. |  |.|.|. ||.   | ..|.. .  .  .. . ...|.. | .  |. |....||. ..
lkkyiht.ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
FAM163 FAM163 family 859-934 2.8e-06 16.3 Pfam-A 8-78 (143) alignment 
Range on Protein: 859-934
Range on HMM: 8-78/143.0
VGGVVLAIIILFIIVLVVCLMRRRSI-AKEKkaraaaaidddcgqfrM----------KDKKLSSTSSVQHNTAQQTKYDEPQYSTV
. | .||..|| .|..| |  | .    |..                           . ..|. || .   .. . . ....  ..
itGgiLAtviLLcIiavLCyCRLqyycCkke................esekeaprileeepdlavtsltpivlsarnrvesaalapl
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1379-1575 5e-06 19.4 In-house 110-309 (346) alignment 
Range on Protein: 1379-1575
Range on HMM: 110-309/346.0
GYREKKAFIIAQSP-MENT--ARDFWKMIVDYKVSAIVMLCGlEEDGEESCYQYWRD-SDVVQF-GEYFIKVEFSkECNGYiERKFHIRSDKDESSWDVI
 .. .. .|.|| | |||     ||| || . ..  . ..   ..   ..    . |     |. |  ||.   . .  |   ... |    .  |  ||
ifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvp.ddklkntttslfndenggyqytgkmfinnrra.dvsgd.pkeytievlpegnsdsvi

qLQVTD-WPQDGVVREPRT--VLQVIDDVIHRQQKIGGGPVVVhCSDTVSRSGVYCSVSIGLEQCKAEGVVDVFQVTKAVRRSKPGAVTTLEQYTSIYDV
  ||    |   . . |.|  ....| .    .|    |  ||       |.  .      ..|       ..... |.... .||.| .. ||.||| .
.cqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai

IDKFL
.  ..
vfdyi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1470-1533 6.4e-06 20.1 In-house 215-287 (350) alignment 
Range on Protein: 1470-1533
Range on HMM: 215-287/350.0
WDVIQLQVTDWPQDGVVREPRTVLQVID---DVIH----R--QQKIGGGPVVVHCSDTVSRSGVYCSVSIGLE
. | ||||  |.  ... .|. .||...   |.|     .   ..  . |..||||  | | |.....   |.
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDslls
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1467-1533 6.6e-06 19.7 In-house 215-290 (349) alignment 
Range on Protein: 1467-1533
Range on HMM: 215-290/349.0
ESSWDVIQLQVTDWPQDGVVREPRTVLQV-------IDDVIHRQ--QKIGGGPVVVHCSDTVSRSGVYCSVSIGLE
|. . ..|||| .|.  ... .| ..||        |||   |.  ..    ...||||    |.||.. . . |.
ekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls