Gene PTPRD-71 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP130_AA protein Get Run
AqueP130_AA_89-306 phosphatase_domain Get Run
AqueP130_AA_1251-1519 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1244-1526 2.4e-144 474.6 In-house 2-301 (301) alignment 
Range on Protein: 1244-1526
Range on HMM: 2-301/301.0
MEELGNHVATCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDF
.|.||.|||..|||.||||||.|..||||||..|.||.|||.||||||||||||||.| ..||||.||||||||.|..||.||..||.||.||..|..||
ledlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdf

WKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDC-------------------NGYIERKFNIFTEKgsSSWDVMQFQVTNWP
|..|...|...|||.....|. ...|.|||..||  . |....... ....                   ||||||||.. ..|  |||||.|.|||.||
WrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWp

TDGIIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTY
.||..|||||||||||.||||||||||||||||||||||||||||||||.|||||||||||||||||.||||||||||||.||.|||.||.|||.|.|||
qdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

AN
||
an
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1241-1521 2.8e-102 337.0 In-house 3-286 (305) alignment 
Range on Protein: 1241-1521
Range on HMM: 3-286/305.0
PVSMEELGNHV---ATCHSNGFEEQYKSLYTGeDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPME
......| ...    . ...|.|.||||||.  ..|. .| .| ||| ||.|.||..||.|| | ....||  ...||||.||.||..| ..|.||.|..
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

NTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIV--QFEEYFVKCLSSKDCNGYIERKFNIFT-EKGSSSWDVMQFQVTNWPTDGIIREPRT
|||.|||..||..||| ||||... |.|...|.||| ||.    .|.|. |.  |.|  ..|||||..| . .. . |  |.|.|.|.|| .|. ... .
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

VLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLH
.|..|..| ..|.|  | |..||||..|.|.||...|.||||..|.|.|||||.|.| .|......|.||||| ......  ...  
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1243-1524 5e-93 306.1 In-house 3-289 (290) alignment 
Range on Protein: 1243-1524
Range on HMM: 3-289/290.0
SMEELGNHVATCHS---NGFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQREYINANYVHGYREKRAFIIAQSPMEN
 ....|..||. |.   .||..|.|.| .|| ...  .| ...||  |||.|| |||||||||   ..   |. ||||| |..||.||...|..|.|..|
pvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn

TVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKG-SSSWDVMQFQVTNWPTDGIIREPRTVLQ
|..||||.|.. ||..||||.   |.|.. |.||| .|.  ...|. .| |. . .|.|||||...  ..   ..  |.|.|.|||. .| . .| |.|.
tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill

VIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTY
|| |... | | | ...||||||||.||.|.|.. .....|| |||.||||| || |  ||| |.| .||  |....  ||.  .||
vieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1244-1527 1.1e-89 295.2 In-house 4-287 (287) alignment 
Range on Protein: 1244-1527
Range on HMM: 4-287/287.0
MEELGNHVATCHS---NGFEEQYKSLYT--GEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLItnpnldMCQREYINANYVHGYREKRAFIIAQSPMEN
.|..|. ||. |    .||..|.. |     ....  .. ...||  ||...| |.|..|. |        .. .|||| .. ||.||.|||||.||| |
vekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPmfn

TVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTE-KGSSSWDVMQFQVTNWPTDGIIREPRTVLQ
|.|.|||.| | .|.||||||  .|. .| ||||| |.. | . || .. |. .  .||||||...  . | ..   |.|.|.|||.  | . ||.|.| 
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

VIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYANF
||.| .. |.| | ...|||||||| ||...|.. .....|| |||.||||| || |  |||.| | .||  |.... .||.  .||..|
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_PTPRD_pd Subfamily PTPRD 1241-1524 2e-79 262.7 In-house 4-287 (564) alignment 
Range on Protein: 1241-1524
Range on HMM: 4-287/564.0
PVSMEELGNHVATCHSN---GFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVHGYREKRAFIIAQSPME
|....|| .|||  ..|    |||.||.. .|.  ...    . ||| ||..||. || .|. | . ..    . .||||....|||...|.| .| |..
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPla

NTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQ
.|..|||.|. ....| ||||  .|| |.. | .|| |..  ...|. |.  .... . |. |.|.. ..| |.|  | ||. |.||  |.  .....|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

VIDEVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTY
.|..| . . . . ||.|||||  | |.|... ... ||. |.|..||..|. | .|. ..  | | .||. |.|.|  .|.  .| 
lirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
0050432 (Phosphotyrosine protein) phosphatases II 1257-1526 6.5e-78 257.5 In-house 42-307 (308) alignment 
Range on Protein: 1257-1526
Range on HMM: 42-307/308.0
NGFEEQYKSLYTGED-KSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDmCQREYINANYVHGY--REKRAFIIAQSPMENTVRDFWKMIVDYKVS
 ..||... |.   .  ..|... ..|| .||.|.|  || .|. |      |     ||||.||.||  . .|.||..|.|..||| |||.|. ...|.
glleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvr

AIVMLCGTEEDGQECCYQYWRES---EIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQqkiG
 ||||. ..|.|.| |.||| ..   ...... ..|..|| . ...|. |.. .   ... |  |..|. |||| .|.  .|. .|. ...| ...   .
vIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...p

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYAN
|||.|||||. |.|.|... . ..||| ..|| ||||.. | .|. .||.|.|..||  .|... .||||. |..|
ggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkln
0040438 (Phosphotyrosine protein) phosphatases II 1252-1524 6.2e-76 251.0 In-house 13-282 (317) alignment 
Range on Protein: 1252-1524
Range on HMM: 13-282/317.0
ATCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYK
     ....|... |..    ..|... ..|| .||...|  ||..|. |   ..       ||||.||.|...||.||..|.|..||| |||.|. ...
lksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqg

VSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQkiG-
|. ||||. .||.|.| |.||| . | .......|..|| . ..|.. |.. .   ..| |  |..|. |.|| .|.   |...|. ...| . ..  . 
vtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dp

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTY
||||.||||. |.|.|... . ..|||.. || |||... | .|. .||||.|..||  .|... .||| . |.
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
0051299 (Phosphotyrosine protein) phosphatases II 1256-1519 7.7e-76 250.6 In-house 22-287 (288) alignment 
Range on Protein: 1256-1519
Range on HMM: 22-287/288.0
SNGFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSA
 .|..|... |.    | ..|... . |.  ||...|  ||..|. | . ..  .    ||||.|..||. ||.||..| |..||| |||.|. ...|. 
ltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrv

IVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTE----KGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQkIG
||||....|.|.| |.||| ... .......|..|| . ...|. |.. .       ... |  |..|..|||| .|.   |. .|. . .|.. ..  |
IvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sg

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
|||||||||. |.|.|... . ..||| ..||.|||... | .|. .||.|.|..||  .||.. .|||
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 160-310 1.2e-75 249.0 In-house 125-294 (301) alignment 
Range on Protein: 160-310
Range on HMM: 125-294/301.0
ECCYQYWRESDIIQYEEYFVKCLSSKDC-------------------NGYIERKFAVQLEKssSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQ
..|.|||..|.  ..|....... ....                   ||||||||.|. .|  |||.|||.|||.||.|||.|||||||||||.||||||
skceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqq

KIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE--IHYYQAMDRLLV
||||||||||||||||||||||||||.|||||||||||||||||.|||||||||||||  .. |...|. | 
kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
0036941 (Phosphotyrosine protein) phosphatases II 1271-1523 8e-75 247.2 In-house 28-282 (297) alignment 
Range on Protein: 1271-1523
Range on HMM: 28-282/297.0
DKSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCY
. |.|.. ...|.  ||.|.|  ||..|. |      |     ||||.|| ||. ||.||..| |..||| |||.|. ...|. ||||.  .|.| | |.
lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

QYWRES--EIVQFEEYFVKCLSSKD--CNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRS
||| .   | .......|..|| .   ...|. |.. .   ... |  |..|..|.|| .|.   |...|. |..| ...... .||||.||||. |.||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

GVYCSVSIALEQCK---AEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
|... . ..|.| .    || ||.... |..|. .||||.||.||  .||.. ..|| . |
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0046845 (Phosphotyrosine protein) phosphatases II 1258-1526 3.5e-74 245.0 In-house 1-282 (284) alignment 
Range on Protein: 1258-1526
Range on HMM: 1-282/284.0
GFEEQYKSLYTGEDK---SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNlDMCQREYINANYVHGY-----REKRAFIIAQSPMENTVRDFWKMIVD
|.||... |.    |   |.|... . |.  ||.|.| .||..|. | . .. |.   .||||.||.||     . |..||..| |..||| |||.|. .
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe

YKVSAIVMLCGTEEDGQECCYQYWRESE-IVQFEEYFVKCLSSKDCNGYIERKFNIFTEK-GSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQ
..|. ||||....|.|.| |.||| ...  .......|..|| . ...|. |.. .  .. .. |  |..|..|.|| .|.  .|. .|. ...| . ..
qnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

K-IGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEG---VVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYAN
.  ||||.|||||. |.|.|... . ..||| ..||   .|||... | .|. .||.|.||.||  .||.. .||||. |...
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1243-1525 2.6e-73 241.9 In-house 13-297 (298) alignment 
Range on Protein: 1243-1525
Range on HMM: 13-297/298.0
SMEELGNHVATCHSNGFEEQYKSLYTGED----KSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHGYREKRAFIIAQSPMEN
 ...| .   . .  |...... | ....    .. ... ...||  ||. .|  .|  |. | ..   .  . .|||| ..|.|... |||..| |...
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPlte

TVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQV
|| |||.|........||||  .|| ..  . .|| ...  ...|  |. ||...   .| ||...  .| ...  | |...|.||  |. .. ..||..
tvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl

IDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYA
...|   ||. |  ||.|.||. | ||| .. ..  ||. |.| ||||||| | .|...||||.| .||. |||..  .|.  ....
lrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0047943 (Phosphotyrosine protein) phosphatases II 1261-1518 3.2e-73 241.9 In-house 16-272 (273) alignment 
Range on Protein: 1261-1518
Range on HMM: 16-272/273.0
EQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC
|... |.    . ..|... ..|| .||.|.|  ||..|. |      ..    ||||.|| ||. ||.||..| |..||| |||.|. ...|. ||||.
eefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLt

GTEEDGQECCYQYWRESE---IVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI-GGGPVV
 ..|.|.| |.||| ...    .......|..|| . ...|. |.. .   . . |  |..|..|.|| .|.   .  .|. |..| . .... ..||||
elvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvv

VHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
||||. |.|.|... . ..|.| ..|| |||... | .|. .||.|.|..||  .||.. .||
VHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 1255-1521 2.6e-72 239.1 In-house 30-292 (297) alignment 
Range on Protein: 1255-1521
Range on HMM: 30-292/297.0
HSNGFEEQYKSLYTGEDKsCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMcQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVS
 ..........|.   .  .||.... || .||.|.|  ||..|. | .... |.    ||||.|| ||.  .|.||..| |...|| |||.|. ...|.
sktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvt

AIVMLCGTEEDGQeCCYQYWRESEIvQFEEYFVKCLSSKDCNGYIERKFNIFTekGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI-GGG
.||||. ..|.|. .|.||| |..  ......|..|. . ..||. |....    .. |  |..||.|.|| .|.   ....|.....| .....  .||
vivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkgg

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLH
||.||||. |.|.|...   ..|||.. || |||... | .|. .||||.|..||  .|... ..|| .
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0043336 (Phosphotyrosine protein) phosphatases II 1253-1518 6.8e-72 237.5 In-house 16-277 (278) alignment 
Range on Protein: 1253-1518
Range on HMM: 16-277/278.0
TCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKV
     ........|..    ..||.....|| .||.|.|  || .|. |   ..       ||||.|| ||. .|.||..| |...|| |||.|. ...|
lnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

SAIVMLCGTEEDGQECCYQYWReSEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQkIGGG
. ||||.. .|.|.. |.|||  .. .......|..|. . ...|. |....   . . |  |.... ..|| .|.   . ..|. . .|.....   .|
ttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsng

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
||.||||. |.|.|... . ..||| . || ||.... | .|. .||||.|..||  .||.. .||
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1241-1523 5.6e-71 234.2 In-house 4-288 (319) alignment 
Range on Protein: 1241-1523
Range on HMM: 4-288/319.0
PVSMEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYREKRAFIIAQSPME
.. ..|| ... . .|.|   .|...| | ...... .    |.||  ||..||  ||  |..| . ..  . . .||||... ||.|...|| .|.|.|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqaPle

NTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSS-SWDVMQFQVTNWPTDGIIREPRTVL
||. |||.|. ....| .|||..  | ..  . .|| | ..... .. |. .. .  ..|| ||... . ..   . .|..|| |.|| ... .. ...|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

QVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
... .. . ..|   ||.|||||. | | | .. ....||. | |||.|||.. . .|  ..  | . .||. |||..  ...  .|
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
0045450 (Phosphotyrosine protein) phosphatases II 1256-1518 7.4e-71 234.7 In-house 26-304 (307) alignment 
Range on Protein: 1256-1518
Range on HMM: 26-304/307.0
SNGFEEQYKSLYTGEDK---SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdMCQREYINANYV--------HGYREKRAFIIAQSPMENTVRDFW
 .|.......|.  ...   ..||.... || .||.|.|  ||..|. | . ..  .    ||||.||        .||. ||.||..|.|...|| |||
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

KMIVDYKVSAIVMLCGTEEDGQECCYQYWRES-EIVQFEEYFVKCLSSKDCNGYIERKFNIFTE-KGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEV
.|. ...|..||||....|.|.| |.||| .. | .......|..|| . ..||. |....    . . |  |..|. |.|| .|.   . ..|. |.||
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

IHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
 . ...  .||||.||||. |.|.|...   ..|.| ..||.   ||.... | .|. .||||....||  .||.. ..|
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 1259-1518 3.4e-70 231.8 In-house 2-262 (263) alignment 
Range on Protein: 1259-1518
Range on HMM: 2-262/263.0
FEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVM
..|....| . . .|... .  . ||. ||.||| .||..|. | ....    . .||||||. |...|...|..| |...||.|||.|... ||. |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LCGTEEDGQECCYQYWRES--EIVQFEEYFVKCLSSKDCN-GYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIgGGPV
|.  ||.|.| |..|| |.  .  .|... ||. . . ..  .| |....  |. . . .| |.|..|||  |.  ... ||... .| ......  ||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
|||||. |.|.|......|.|.....|  ||.|.. |..| ..||.|.||.||. |||.|  |.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1259-1518 3.4e-70 231.8 In-house 2-262 (263) alignment 
Range on Protein: 1259-1518
Range on HMM: 2-262/263.0
FEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVM
..|....| . . .|... .  . ||. ||.||| .||..|. | ....    . .||||||. |...|...|..| |...||.|||.|... ||. |||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LCGTEEDGQECCYQYWRES--EIVQFEEYFVKCLSSKDCN-GYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIgGGPV
|.  ||.|.| |..|| |.  .  .|... ||. . . ..  .| |....  |. . . .| |.|..|||  |.  ... ||... .| ......  ||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpi

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
|||||. |.|.|......|.|.....|  ||.|.. |..| ..||.|.||.||. |||.|  |.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1242-1526 2.5e-69 228.8 In-house 2-288 (318) alignment 
Range on Protein: 1242-1526
Range on HMM: 2-288/318.0
VSMEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSI-GYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHGYREKRAFIIAQSPME
.|.|.| .||.  ...|   ..|.|. |   |... |.   .. ||| ||. ||. ||. |. | .    .  . .||||||. |||.|.|.| ||.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmle..geegsDyinanyidGyrrkkayiaaqaPlp

NTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQ
.|..|||.|. . . . ||||  .|| |.. . .|| ...  ....  |.  ...... |. |.|..  .. ..| .| |...|.||  |.  .. ..|.
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslld

VIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYAN
.. .| . ||| | ||.|||||  | | ||.. |.| ||. |||..|||||. | .|. ..  | | |||  ||.|.  .|.   |...
lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_Ptp69D_pd Subfamily Ptp69D 1256-1519 3.4e-67 221.7 In-house 21-287 (307) alignment 
Range on Protein: 1256-1519
Range on HMM: 21-287/307.0
SNGFEEQYKSLY-TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSA
  |... |..|  .  |||....  ..|.  ||...|. .|..|. | . .  .  . .||||....||.||. ||.|| |.|.|. |||.|| . .|  
dfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtl

IVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGS-----SSWDVMQFQVTNWPtDGII-REPRTVLQVIDEVIHRQQK
||||   .|  .. | .|| . ..||...  ||. |.. .. ||.|.... . | .      |  |.|.. |.|. | .. . .|..|..|..| . ...
ivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykl

IgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
   .|.|||||  |.|||.. .... |.|.|||  ||.|...| .|. ..  |. |.||. .|  .  | .
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
0040439 (Phosphotyrosine protein) phosphatases II 1273-1518 3.5e-67 221.9 In-house 2-246 (249) alignment 
Range on Protein: 1273-1518
Range on HMM: 2-246/249.0
SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQY
..|... . ||  ||...|  || .|. |   |.|  .   ||||.|..||. ||.||..| |...|| |||.|. ......||||. ..| |.| |.||
eysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSV
| ... .......|..|| . ...|. |.. .   . ..|  |...|.|.|| .|.   . ..|. |..| . ....  ||||.||||. |.|.|...  
wplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

SIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
 ..||| . |. ||.... | .|. .||||....||  .||.. ..|
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 1282-1514 1.7e-66 219.4 Pfam-A 1-233 (235) alignment 
Range on Protein: 1282-1514
Range on HMM: 1-233/235.0
NKAFNRFKNITVYDDNRITLitnpnL---DMCQreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ES
||  ||.|.|..||..|. |         . ..  |||||||.||.||..||..| |...|. |||.|....||..||||.  || |.| | |||   |.
nkkknRykdilpydktrvkl.....kgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeee

EIVQFEEYFVKCL-SSK-DCNGYIERKFNIFTEKGSS-SWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSI
| .......|..  ..| |...|. ||...  .|..| .  |.|...||||  |. ..|. .|..|..| ... .   ||||||||. |.|.|......|
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldi

ALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
.|||..||. |||.|. |..|...||.|..|.||  .|..|
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1282-1514 1.7e-66 219.4 In-house 1-233 (235) alignment 
Range on Protein: 1282-1514
Range on HMM: 1-233/235.0
NKAFNRFKNITVYDDNRITLitnpnL---DMCQreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ES
||  ||.|.|..||..|. |         . ..  |||||||.||.||..||..| |...|. |||.|....||..||||.  || |.| | |||   |.
nkkknRykdilpydktrvkl.....kgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeee

EIVQFEEYFVKCL-SSK-DCNGYIERKFNIFTEKGSS-SWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTVSRSGVYCSVSI
| .......|..  ..| |...|. ||...  .|..| .  |.|...||||  |. ..|. .|..|..| ... .   ||||||||. |.|.|......|
esltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldi

ALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
.|||..||. |||.|. |..|...||.|..|.||  .|..|
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1276-1525 1.6e-65 215.8 In-house 3-249 (250) alignment 
Range on Protein: 1276-1525
Range on HMM: 3-249/250.0
IGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQEcCYQYWRE
..   .||  ||. .|  .|  |. | ..   .  . .|||| ..|||.|..|||..|.|...|. |||.|....|...||||   .| ... . |||  
vakkpqnkeknryadiialdssrvvLekekgdk..esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

SEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIAL
 .  .. .  |. ||..    |. ||. .  .| ...  | |.. ..||  |. .. ..||.....|   ||..| .||.|.||  |.||| .. ..  |
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

EQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHSTYA
|. | | |||||.| | .|. .|.||..|.||...||.|  .|.  . ||
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
0042113 (Phosphotyrosine protein) phosphatases II 1274-1518 9e-65 213.8 In-house 1-243 (245) alignment 
Range on Protein: 1274-1518
Range on HMM: 1-243/245.0
CSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYW
.|... . || .||...|  ||..|. |   ..   .   ||||.||.||| .. ||..| |...|| |||.|. ......||||. .||.|.. |.|||
ysvallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

RESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSI
 ..|........|..|| . ...|. |....  .. . |  |.... ..|| .|.   ....|.....| . ... ..|||.||||. |.|.|... . .
plgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

ALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
.||| ..|. |..... | .|. .||||.|..||  .||.. ..|
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 1263-1519 3.1e-64 212.4 In-house 14-273 (278) alignment 
Range on Protein: 1263-1519
Range on HMM: 14-273/278.0
YKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITlitnpnldmcqrEYINANYVHGYreKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTE
.  | .|   ... .  ..|...||.|.|  || .|.             .||||.|..||  ...||..| |...|| |||.|. ......||||.. .
efllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

EDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTE----KGSSSWDVMQFQVTNWPTDGIIREP--RTVLQVIDEVIHRQQK--------
|.|.| |.||| |.. .......|..|| . .. |. |....       ..  |. | ... ..||  |.  .|  . .|...... .....        
elgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

----IGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaEGVVDVFQVTKSVRRSKPG-AVTTLDQYSSIYEVISMYLK
     .||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..|.||  .||.. ..|.
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPRA_pd Subfamily PTPRA 1245-1518 8.9e-61 200.6 In-house 20-295 (330) alignment 
Range on Protein: 1245-1518
Range on HMM: 20-295/330.0
EELGNHVATCHSNGFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDF
||  .  ..  .. | |....| .|. . .. .   |.||  ||. ||  || .|. | .    .  . .|||| ...||.||  || || | |.|| ||
eeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaqGPkeetvedf

WKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIF----TEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVI
|.|| ..| ..||||   .|  .| |.||| .  .| . .  |.   .. .. |  ||| .     . .  .|  | ||  | ||  |.  ||. .|...
wrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkll

DEVIHRQQKIGGgPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
 .| . .|. .| |.|||||  | |.| .. ..  ||. |||..||||.. |..|  .|  | |. ||  ||.|.  | 
kkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPRK_pd Subfamily PTPRK 1251-1514 1.9e-60 199.4 In-house 16-273 (314) alignment 
Range on Protein: 1251-1514
Range on HMM: 16-273/314.0
VATCHSNGFEEQYKSLYTGedksCSIGYSEDNKAFNRFKNITVYDDNRITLITNpnLDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDY
. .... || |.|.||. |          ..|.. ||...|  ||  |..|||    .  . .||||... .|.  .|||..| |...||.|||... |.
lkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvfliti..dgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvyde

KVSAIVMLCGTEEDGQECCYQYWRESEIVqFEEYFVKCLSSKDCNGYIERKFNIFT-EKGS-SSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQK
. ..||||    | |.  |..|| |   | ...  |......  . .. | |..   ..|      | ||| ..||. ..  . ...|... .| . |..
ncasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee

iGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
 . |..|||||    |.|... ..| |.  . |||||||.. |..| .|.  | | .||  ||.||
.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPRG_pd Subfamily PTPRG 1243-1517 2.2e-60 199.4 In-house 2-286 (563) alignment 
Range on Protein: 1243-1517
Range on HMM: 2-286/563.0
SMEELGNHVATCHSNG---FEEQYKSLY---TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQrEYINANYVHGYREKRAFIIAQSPM
 ..|. .||| .|..|   |.|....|    . .|  ..    ..||  ||  ||. ||  |..|   |. .    .||||||..||. ..|||..| |.
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgpl

ENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFT---EKGSS---SWDVMQFQVTNWPTDGIIR
..|. |||.|| . .|. |||.   .|.|.. | .|| . | .....  |.  ...    | .|.. |     .|...      |.|.. |.||  |   
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

EPRTVLQVIDEViHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMY
 .  ||. .     . .|   ||.|||||  |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| .||  .....   
hslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1255-1519 1.8e-57 189.6 In-house 13-277 (281) alignment 
Range on Protein: 1255-1519
Range on HMM: 13-277/281.0
HSNGFEEQYKSLYT-GEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVS
...|| |.|..|.  | |.. .  ....|.  ||..||. ||  |...  | .    . .|||||.| ||......|..|.|. ... .||.|....|||
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

AIVMLCGTEEDGQECCYQYWRESE-IVQFEEYFVKCLSSKDCNGYIERKFNIfTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGGG
||||.    | |.  |..|| . .  ... .. || ..... . ||||||.. ..... . .| |.. |.||  |.  ... .|.  .|| . ..|    
aivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktka

PVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
|.|.|||  | |.|.| ..  ......||   .|| .| ...|...   | |. ||. .| ..  .|.
plvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPRB_pd Subfamily PTPRB 1240-1519 4.7e-57 188.3 In-house 5-286 (293) alignment 
Range on Protein: 1240-1519
Range on HMM: 5-286/293.0
LPVSMEELGNHVATCHS---NGFEEQYKSLY-TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHGYREKRAFIIAQSP
 |...|.. .||.. ..    .| |.|..|   |.|.....  .. |.| ||..||  || .|. | .    |  . .||||||..||. .| || .| |
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyipgynsprefiatqGP

MENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES-EIVQFEEYFVKCLSSKDCNGYIERKFNIFTekGSSSWDVMQFQVTNWPTDGIIREPRT
. .|| |||.|. . |.|.||||  . | |.. | .|| .  | |.. .  |. ..... . .. |...|    .... .|.|.. | ||  |.  ...|
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektkt

VLQVIDEVIHRQ-QKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
.|. . .| ... ..   .|.|||||  | |.|.. ..   |.. . | .||.| .  ..|...   | | .||  |....  .|.
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN6_pd Subfamily PTPN6 1239-1523 1e-56 187.2 In-house 8-302 (306) alignment 
Range on Protein: 1239-1523
Range on HMM: 8-302/306.0
TLPVSMEELGNHVATCHSNGFEEQYKSLYTGE---DKSCSIGYSEDNKAFNRFKNITVYDDNRITLItnpNLDMCQREYINANYVHGY--REKRAFIIAQ
..   ..|| ..  . . .||||....| . |     | . |   .||  ||.|||  .|..|..|    . .. . .||||||...    .....| .|
eieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatq

SPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIV-QFEEYFVKCLSSKDCNGYIERKFNIF-TEKGSSSWDVMQFQVTNWPTDGIIRE
  .|.|| |||.|... .   |||.    | |.| |..|| ..|   .. .. |...|.|. . || |....  ..|.... .|.|.. ..||  |. ..
gclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkd

PRTVLQVIDEVIHRQQKIG---GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
| .||. ...| ..|...     ||.|||||. . | | .  . | |.. . .|.   .|. .. ||||. . | | | .||  .|..|..|.. ...
pgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1249-1515 1.5e-56 186.6 In-house 13-276 (288) alignment 
Range on Protein: 1249-1515
Range on HMM: 13-276/288.0
NHVATCHSNGFEEQYKSL-YTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMI
..      .||.|.|.||   ...|| ..|    |.  ||..||  || .|. |   .. .  . .||||.|..|...|...| .|.|. .|| |||...
akksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyidgekkkkkyiatqgPladtvndfWelv

VDYKVSAIVMLCGTEEDGQECCYQYWRESEI-VQFEEYFVKCLSSKDCNGYIERKFNIFteKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQ
 ..|.| |||| .  |.|.. | .|| ...  ... .  |. ..||. . ...||. .   |  .  .. |.| . || .|. .  . .|.... |   .
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvan

QKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVIS
|.   ||..||||. | |.|.. ..  .... ..| ..||. . . .|....  | || ||  ||||. 
qad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1254-1523 1.8e-56 186.3 In-house 16-282 (315) alignment 
Range on Protein: 1254-1523
Range on HMM: 16-282/315.0
CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLIT-NpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKV
 |.  | |... |   .     ..  ..|   ||.|||  .| .|. |   .   |  ...|||| |.... . .|.| .| | . .| |||.|....||
rhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevid...dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekv

SAIVMLCGTEEDGQECCYQYWRE--SEIVQFEEYFVKCLSSKDCNGYIERKFniFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRqQKIG
..|||.   .|. .  | ||| .  .. |.| .. |. || . . . . ||.   | |. .|  | ||| |.||  |. ..  ..|..| ||    ..  
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkk

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
  ...||||  | |.|| .|.   ..| | . .||||.. | .|. .|  | | ..|. ||...  .|. . |
efsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt
0037934 (Phosphotyrosine protein) phosphatases II 1274-1518 9.6e-56 184.4 In-house 2-242 (243) alignment 
Range on Protein: 1274-1518
Range on HMM: 2-242/243.0
CSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMcqREYINANYVHGYreKRaFIIAQSPMENTVRD----FWKMIVDYKVSAIVMLCGTEEDGQECC
.||. .. |.  ||...|  ||..|. |      .     |||||.. ..  .| .|. | |...|| |    ||.|. ......||||. ..| |.| |
fsiallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekc

YQYWReSEIvQFEEYFVKCLSSKDCNGYIERKFNIFTEK-GSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQK-------IGGGPVVVHCSDT
.|||  .|. ......|..||.. ...|. |.. .   . .  .. |.... ..||  |.  .|  .|. .|||.  ...        .||||.||||  
aqywp.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VSRSGVYCSVSIALEQCkaeGvVDVFQVTKSVRRSKPG-AVTTLDQYSSIYEVISMYL
|.|.|...   . |...   | ||.... | .|. .|| ||.|..||  .||.. ..|
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1282-1521 2.3e-55 182.8 In-house 51-287 (297) alignment 
Range on Protein: 1282-1521
Range on HMM: 51-287/297.0
NKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHGYREkrAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQeCCYQYWRESEIVQF
|   .|.|||  || .|..|      |  . .|.|| .|.|...   .|  | ||..|| |||.|..|..||.||||   .|  .  | .|| .. ...|
nfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttf

EEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIR--EPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCK
 .  |. || ....|.|.|....  .|  .   | |.| ..||.. . |  . ...|..|.|| .  ..   ||..|||.  | | ||....   . . |
GdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeak

AEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLH
 |  ||.|.. | .|...|  | | .||. .|...  .|  .
rekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1243-1514 4.5e-55 181.8 In-house 7-275 (315) alignment 
Range on Protein: 1243-1514
Range on HMM: 7-275/315.0
SMEELGNHVAT---CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITL-ITNPNldmCQREYINANYVHGYREKRAFIIAQSPMEN
 ...|  .||       |||...|.|.  |. .   .     ||  ||. ||  ||  |. | ... .    . .|.|||.. ||  || .| ||.|  .
pldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllend...phsdyvnanfidGynkkrryiaaqgpnva

TVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVqFEEYFVKCLSSKDCNGYIERKFniFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQV
.|.|||... ..... |||| .. |. .. . .|| . ... . .. |   | .  . |  | .   .  |.   .|.|...| ||. |. .   .....
svkdfwrlvfeedigkivmltnlvegekrkaekywpdkkvi.yGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnl

IDEVIHRQQKIGgGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
|  |   ...   |..|||||. | |.| .....  |.| .|| ..||... . ||. . ..| ...||  ||...
irtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1254-1518 7.2e-55 181.4 In-house 20-288 (325) alignment 
Range on Protein: 1254-1518
Range on HMM: 20-288/325.0
CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVS
   .||  ... | . . ..  .    .||| |||||.  .| .|. | |    |  . .||||.|.. ...|  |. ||.|. .|. |.|....|.. |
qdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkk..ddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcs

AIVMLcGTEEDGQECCYQYWRES--EIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI--
 .|.|    . |.. | .|| .   . ..|    ||  . ..   |. |....   |.  .  | |||.  |.  |  . | |.. ... | . ....  
vvvvl.neldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

---GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
   . .|..||||. | |.||. |.  ||..   |  ||.|.. | .|. .|  | | |||. ||| .  ..
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1257-1514 9.2e-55 180.5 In-house 9-262 (283) alignment 
Range on Protein: 1257-1514
Range on HMM: 9-262/283.0
NGFEEQYKSLYTgEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldmcqrEYINANYVH---GYREKRAFIIAQSPMENTVRDFWKMIVDYKVS
. | |..| |    |... |  ...|| .||...| ..| .|. | ....      .|||| ..     |.... .||||||...||.|||||. | |..
klfrevlkrlsv.pdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

AIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTE-KGSSSWDVMQFQVTNWptdgIIREPRTV---LQVIDEVIHRQQKI
|||||    || .. | ||| .   ... |. |        | .| ... . ..    |.  .  .|| .|    .  .. ..   |  .. ||  |.. 
aivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqtes

GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
  ||.||||| .. |..|....| .... ..| |||||.| | .|  ...|| |||||  ..|..
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1255-1523 6.7e-54 177.8 In-house 16-281 (515) alignment 
Range on Protein: 1255-1523
Range on HMM: 16-281/515.0
HSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITL-ITNpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVS
|   | |... |   .    ..   | |   ||.|||  || .|. | . |   |  . .|.|| |....   .|.| .| | . .| |||.......|.
httlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevin...dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvt

AIVMLCGTEEDGQECCYQYWRE--SEIVQFEEYFVKCLSSKDCNGYIERKFNIFteKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGg
.|.|.   .|. .  | .|| .  .. |.| .. |. .| . | | | ||...   ||. |  | ||. |.||  |. .. ...|..| ||   ....  
tiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl..kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.

GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
 |...|||  | | ||..|.   . . |   .||||.. . .|. .|  | | .||. ||...  .|.   |
hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrnt
subfamily_PTPN12_pd Subfamily PTPN12 1272-1519 7.6e-53 174.3 In-house 30-278 (290) alignment 
Range on Protein: 1272-1519
Range on HMM: 30-278/290.0
KSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQ
 | . | .| |.. ||.|.|  || .|..| .. . .  . .|||||...|  .| ..| ||.|. .|. |||.|| ...|. .||.|   | |.  | .
ysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWRES--EIVQFEEYFVKCLSSKDCN-GYIERKFNIFTEkgSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQkIGGGPVVVHCSDTVSRSGVY
|| |.  | ..|.|. |.. . | .. ... | ... ..  . |  | ||. |.||  |. . . ..|..|..| ..|.     |.|||||  | | |. 
YWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGti

CSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
... .. |. ||| .   .|||..  ..|. .. .| | .||. .|. .  ...
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 160-301 2.3e-50 166.5 In-house 129-272 (305) alignment 
Range on Protein: 160-301
Range on HMM: 129-272/305.0
ECCYQYWRESDII--QYEEYFVKCLSSKDCNGYIERKFAVQL-EKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVS
..|.||| ||     ...|. |.  |.|  ..|||||. .   .... | .|||.|.|.|| .|| ... ..|..|..| ..|.|  | |..||||..|.
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEiHY
|.||...|.||||..|.|.|||||.|.| .|......|.||. .|
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtld.qY
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1264-1520 1.8e-49 163.2 In-house 2-266 (270) alignment 
Range on Protein: 1264-1520
Range on HMM: 2-266/270.0
KSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLitNPNLDMCQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTE
| |  .| .. ..     .|..||...|      |..|  ..  .  . .|||||||.|. . |...| |..|...|...||.||.. ||.||||. | |
keldkeetsesdlpeaargkklnRyadiLPsPatRvrl..eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgle

EDGQECCYQYWRES--EIVQFEEYFVKCLSSK--DCNGYIERKFNIFtEKGSSSwDVMQFQVTNWPTDGIIREPR------TVLQVIDEV-IHRQQKIGG
|.|.. | .|| ..  | |..|. ..| |...    .||| .. ..  |||..   .. |. ..|| .|. ||.        .|... .|  .....  .
EkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeer.rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka

GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKL
.|..||||. | |.|.   . ||..  . .. ||| .. . .|. ..  | . .||  .|.....| . 
ePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPN9_pd Subfamily PTPN9 1244-1517 2.9e-49 162.7 In-house 3-289 (297) alignment 
Range on Protein: 1244-1517
Range on HMM: 3-289/297.0
MEELGNHVATCHSNGFEEQYKSLYTGEDK-SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRD
.||| ..|   . .|  ..|. .   . .       .  |   ||....  ||. |..| . .. .  . .|||||.| ||..|.||| .| |...||.|
ieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsd

FWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVID
||.|. . .|  |||   ..| |.  | |||   | .  .| .. |. .. .  . | .|...|   | . |  |. ||.. ||  |. ..  ..|.|..
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

EVIHRQQ------------KIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMY
.| ..|             .. | |.|||||  . |.| .... |.|.. . .|.|||... | .|  .  .. | .||   |  .  |
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
0050432 (Phosphotyrosine protein) phosphatases II 95-302 8e-49 162.0 In-house 42-290 (308) alignment 
Range on Protein: 95-302
Range on HMM: 42-290/308.0
NGFEEQYKSLYTGED-KSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDmCQREYINANYVHEC--------------------------------
 ..||... |.   .  ..|... ..|| .||.|.|  || .|. |      |     ||||.||. .                                
glleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvr

---------------CYQYWRES---DIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQqkiG
               |.||| ..   ....|. ..|..|| . ...|. |.. ..  ... |  | .|. |||| .||  .|. .|. ...| ...   .
vIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...p

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
|||.|||||. |.|.|... . ..||| ..|| ||||.. | .|. .||.|.|.| ...
ggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylf
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1280-1515 9.7e-49 161.4 In-house 59-288 (319) alignment 
Range on Protein: 1280-1515
Range on HMM: 59-288/319.0
EDNKAFNRFKNITVYDDNRITLitNPNLDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgteedgQECCYQYWRESEIV
..||  ||. ||  .| |.. |  ..   .   .|||| .| ||. |  .| || |..||. |||.|| .|..|.||.|       .. | |||     .
dqnkdknriinilafdknvvkl..erliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

QFEEYFVKCLSSKDCNGYIERKFNIFT-EKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIALEQ
. |.. ||  | .... |. |....    |     .. ||    ||  |    |  ...... | | ..|  .  ..|||||  | |.|||  . . |..
keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldr

CKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVIS
 | |  |||... . .|. ..  |  | ||  ||  . 
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_CG7180_pd Subfamily CG7180 1263-1518 1.5e-48 159.9 In-house 23-290 (296) alignment 
Range on Protein: 1263-1518
Range on HMM: 23-290/296.0
YKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTE
.|   . |   |  |. ..|.  ||  ..  || ||. | .    .  .  |||| || ..  |...|. . |...|| .||... | ..||.|.|. | 
lkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktf

EDGQeCCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTE--------K--GSSSWDVMQFQVTNWPT-DGIIREPRTVLQVIDEVIHRQQKI--
.  .  . .|| .    |. | ||. ...|       |.| .  .        |        |..||.| |.  | .     ......  |   ..|.  
dfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvde

--GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
    |||||..|| .||||||... ..||. . |. ||||.  | .|||.|. | . ..|  ||.|.. ..
dpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1280-1515 1.7e-48 160.6 In-house 23-252 (284) alignment 
Range on Protein: 1280-1515
Range on HMM: 23-252/284.0
EDNKAFNRFKNITVYDDNRITLitNPNLDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgteedgQECCYQYWRESEIV
..||  ||. .|  .| |.. |  ..   .   .|||| .. ||. |  .| .| |..||. |||.|| .|..|.||.|       .. | |||     .
dqnkdknrighilafdknvvkl..erliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

QFEEYFVKCLSSKDCNGYIERKFNIFT-EKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGG-GPVVVHCSDTVSRSGVYCSVSIALEQ
. |.. ||  | .... |. |....    |     .. ||    ||  |    |  ...... | | ..|  .  ..|||||  | |.|||  . . |..
keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

CKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVIS
 | |  |||... . .|. ..  |  | ||  ||  . 
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1284-1519 1.5e-47 157.0 In-house 30-269 (274) alignment 
Range on Protein: 1284-1519
Range on HMM: 30-269/274.0
AFNRFKNITVYDDNRITLITNPNlDMCQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIV---
  ||.|.|   .  |..| .. . .  . .||||||..||.| ..|.. .| |. ||| |||.||   .|. ||||   .|  .. | .|. ..| .   
tknryktilPnensrvllesess.ededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

-QFEEYFVKCLSSKDCNGYIERKFNIFTEKGssSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI--GGGPVVVHCSDTVSRSGVYCSVSIALE
 ....  .|  . ...|.|  ||. .   .   . .|. .  |.||     ....|.|....|| . ...     .|||||||  . | |.. ..|||. 
erygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavr

QCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
| ..|.||||....  .|  . | | | .||  |......|||
qlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 160-299 1.9e-47 156.6 In-house 131-271 (290) alignment 
Range on Protein: 160-299
Range on HMM: 131-271/290.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKS-SSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRS
. |.||| .||  .|.|. .| |. . .|.|||||. |. ..|  .. .| |.|.|||. .| . .| |.|.|| |... | | | ...||||||||.||
vkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrs

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
.|.|.. .....|| |||.||||| || |  ||| |.| . 
avfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqq
subfamily_PTPN3_pd Subfamily PTPN3 1261-1514 2.3e-47 156.3 In-house 19-271 (280) alignment 
Range on Protein: 1261-1514
Range on HMM: 19-271/280.0
EQYKSLYTG-EDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNlDmcqreYINANYV----HGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAI
 |.. ||   .. ..|.    .| . ||...|. ||. |..|  ... |     |||||||     .      .|..| |...|. |||.|. . |.| |
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.d.....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssli

VMLCGTEEDGQECCYQYWRE-SEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEViHRQQKIGGGPV
|||  . |.|.  |.||| | .. ... |. ||| ...  . |. |.. .  .. . .  ..|.| ..||  |.  ..  .|.....| .....    ||
vmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePv

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
|||||  . |.||.  . .||    |.  | . .. . .|  .   | | .||  . | |
vvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
0051299 (Phosphotyrosine protein) phosphatases II 94-299 3.9e-46 153.2 In-house 22-274 (288) alignment 
Range on Protein: 94-299
Range on HMM: 22-274/288.0
SNGFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVH---------------------------------
 .|..|... |.    | ..|... . |.  ||...|  ||..|. | . ..  .    ||||.|..                                 
ltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrv

------------ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLE----KSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkIG
            | |.||| ... ..|....|..|| . ...|. |.. |.      ... | .| .|..|||| .||   |. .|. . .|.. ..  |
IvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sg

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
|||||||||. |.|.|... . ..||| ..||.|||... | .|. .||.|.|.| 
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeq
0046845 (Phosphotyrosine protein) phosphatases II 96-301 1.1e-45 151.6 In-house 1-264 (284) alignment 
Range on Protein: 96-301
Range on HMM: 1-264/284.0
GFEEQYKSLYTGEDK---SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNlDMCQREYINANYVHEC-------------------------------
|.||... |.    |   |.|... . |.  ||.|.| .||..|. | . .. |.   .||||.||. .                               
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe

-------------------CYQYWRESD-IIQYEEYFVKCLSSKDCNGYIERKFAVQLEK-SSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQ
                   |.||| ...  ..|....|..|| . ...|. |.. .. .. .. |  | .|..|.|| .||  .|. .|. ...| . ..
qnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

K-IGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEG---VVDVFQVTKSVRRSKPGAVTTLEIHY
.  ||||.|||||. |.|.|... . ..||| ..||   .|||... | .|. .||.|.|||  .
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyr
0040438 (Phosphotyrosine protein) phosphatases II 90-300 1.4e-45 151.4 In-house 13-265 (317) alignment 
Range on Protein: 90-300
Range on HMM: 13-265/317.0
ATCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHEC----------------------------
     ....|... |..    ..|... ..|| .||...|  ||..|. |   ..       ||||.||.                              
lksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqg

-----------------CYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkiG-
                 |.||| . . ..|....|..|| . ..|.. |.. |.  ..| |  | .|. |.|| .||   |...|. ...| . ..  . 
vtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dp

GGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
||||.||||. |.|.|... . ..|||.. || |||... | .|. .||||.|.|  
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqy
subfamily_PTPN23_pd Subfamily PTPN23 1258-1516 2.6e-45 149.5 In-house 16-278 (288) alignment 
Range on Protein: 1258-1516
Range on HMM: 16-278/288.0
GFEEQYKSLYTGED---KSCSIGYSEDNKAFNRFKNITVYDDNRITLItnpnldMCQREYINANYVHGYREK-RAFIIAQSPMENTVRDFWKMIVDYKVS
......| | . .|   .. ||  .. .   ||...|  || ||..|         . .|||| .|..       ||..|.|...|. |||.|... |.|
aldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkss

AIVMLCGTEEDGQECCYQYWR--ESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIH---RQQK
 ||||   || |.. . .||   . | |.|... | . | .. . ..||.... |.. .   .|.  |.|.||  |.   | |.||..||| .    .|.
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqr

IGGGPVVVHCSDTVSRSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
    |.|||||  | |.||.. |  |...  | .|..|. || . .|. .   | . .|.   ||..  
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
0036941 (Phosphotyrosine protein) phosphatases II 109-300 3.7e-44 146.6 In-house 28-266 (297) alignment 
Range on Protein: 109-300
Range on HMM: 28-266/297.0
DKSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHE---------------------------------------------CCY
. |.|.. ...|.  ||.|.|  ||..|. |      |     ||||.||                                                |.
lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

QYWRES--DIIQYEEYFVKCLSSKD--CNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRS
||| .   . ..|....|..|| .   ...|. |.. |.  ... |  | .|..|.|| .||   |...|. |..| ...... .||||.||||. |.||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

GVYCSVSIALEQCK---AEGVVDVFQVTKSVRRSKPGAVTTLEIH
|... . ..|.| .    || ||.... |..|. .||||.|||  
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqy
0047943 (Phosphotyrosine protein) phosphatases II 99-302 5e-44 146.2 In-house 16-263 (273) alignment 
Range on Protein: 99-302
Range on HMM: 16-263/273.0
EQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHE-------------------------------------
|... |.    . ..|... ..|| .||.|.|  ||..|. |      ..    ||||.||                                       
eefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLt

--------CCYQYWRESD---IIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-GGGPVV
         |.||| ..     ..|....|..|| . ...|. |.. ..  ... |  | .|..|.|| .||   .  .|. |..| . .... ..||||
elvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvv

VHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
||||. |.|.|... . ..|.| ..|| |||... | .|. .||.|.|.|  ..
VHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrf
subfamily_PTPN14_pd Subfamily PTPN14 1268-1519 7.1e-44 145.0 In-house 35-297 (300) alignment 
Range on Protein: 1268-1519
Range on HMM: 35-297/300.0
TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmcQREYINANYVHG--YREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDG
  ||  .| .  ..|.  ||||..  |.|||. |... .    . .||||  ..     ..| .|.||.|.|.||.|||.|. . .|. ||||  .||||
kredallstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedg

QECCYQYWRES----EIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVI----HRQQKI----GGGP
.| ...|. ..    . |.|... |    |.| . .| .....     .   .|. .| |.|| .|. ..... |. ..||     . ....       |
keksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

VVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
|.||||. | |.||   . . ..  . . ..|. .| . .|. .   | || ||  .|.|.  |||
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 160-299 2e-43 143.4 In-house 126-266 (287) alignment 
Range on Protein: 160-299
Range on HMM: 126-266/287.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEK-SSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRS
| ||||| |.. . . || .. |. .  .||||||. |. .. ...  .| |.|.|||.  | . ||.|.| ||.| .. |.| | ...|||||||| ||
evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
...|.. .....|| |||.||||| || |  |||.| | | 
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtveq
0043336 (Phosphotyrosine protein) phosphatases II 91-300 4.3e-43 143.2 In-house 16-266 (278) alignment 
Range on Protein: 91-300
Range on HMM: 16-266/278.0
TCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHEC-----------------------------
     ........|..    ..||.....|| .||.|.|  || .|. |   ..       ||||.||                                
lnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

----------------CYQYWReSDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkIGGG
                |.|||  .. ..|....|..|. . ...|. |.. |   ... |  |.... ..|| .||   . ..|. . .|.....   .|
ttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsng

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
||.||||. |.|.|... . ..||| . || ||.... | .|. .||||.|..  
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqy
0045450 (Phosphotyrosine protein) phosphatases II 94-299 1.2e-42 142.1 In-house 26-292 (307) alignment 
Range on Protein: 94-299
Range on HMM: 26-292/307.0
SNGFEEQYKSLYTGEDK---SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdMCQREYINANYV--------------------------------
 .|.......|.  ...   ..||.... || .||.|.|  ||..|. | . ..  .    ||||.||                                
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

---------------------HECCYQYWRESD-IIQYEEYFVKCLSSKDCNGYIERKFAVQLE-KSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEV
                     .| |.||| ...  ..|....|..|| . ..||. |.. |.   ... |  | .|. |.|| .||   . ..|. |.||
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

IHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLEI
 . ...  .||||.||||. |.|.|...   ..|.| ..||.   ||.... | .|. .||||...| 
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeq
0039614 (Phosphotyrosine protein) phosphatases II 93-300 2.4e-42 140.8 In-house 30-278 (297) alignment 
Range on Protein: 93-300
Range on HMM: 30-278/297.0
HSNGFEEQYKSLYTGEDKsCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMcQREYINANYVHEC-------------------------------
 ..........|.   .  .||.... || .||.|.|  ||..|. | .... |.    ||||.||                                  
sktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvt

--------------CYQYWRESDIiQYEEYFVKCLSSKDCNGYIERKFAVQLekSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-GGGP
              |.||| |.   .|....|..|. . ..||. |.. |.   .. |  | .||.|.|| .||   ....|.....| .....  .|||
vivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggp

VVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
|.||||. |.|.|...   ..|||.. || |||... | .|. .||||.|..  
vlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy
subfamily_PTPN13_pd Subfamily PTPN13 1271-1519 2.8e-42 139.9 In-house 26-270 (273) alignment 
Range on Protein: 1271-1519
Range on HMM: 26-270/273.0
DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldmcqreYINANYVHGYR--EKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQEC
 ..|..| ...||. ||..|.  ||. |..|  . .       ||||....     ..  .|..| |. .||.|||.|. . |.. |.|.    |.|.  
ldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk

CYQYWRESEI--VQFEE-YFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQkiGGGPVVVHCSDTVSRS
| .|| ||.   .. .. . |. |  .. .|.  |....   . . | .|.... ..||  |. ...  .||.. || . |.    ||.|||||  . ||
chrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrs

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
|.. .. ..|.  . .  .|| .. ...|. . | | | |||  .|..|   ||
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1284-1522 4e-42 139.0 In-house 40-281 (287) alignment 
Range on Protein: 1284-1522
Range on HMM: 40-281/287.0
AFNRFKNITVYDDNRITLITNPNLDMcqrEYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEI-VQFE
  ||. ..  .||.|. | ....|     .||||||| .|... ||| ||.|.  ||||||..... ........    |...  ||.|| | |  ..  
kknryadvlPiddtrvllsaegelGs...dyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYFVKCLSSKD--CNgYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIRE----PRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE
 | |  |. .    . |  | . .   ..  .  | |... .|| ...        | ||.| . .  ...  . ||.|||..  . |||.. .. . ..
GysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHS
. .  | ||| .|   .|  . . | .  |.  .|| .  | |   
rledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnp
0040439 (Phosphotyrosine protein) phosphatases II 111-299 5.6e-40 132.9 In-house 2-234 (249) alignment 
Range on Protein: 111-299
Range on HMM: 2-234/249.0
SCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQreYINANYVH---------------------------------------------ECCYQY
..|... . ||  ||...|  || .|. |   |.|  .   ||||.|..                                             | |.||
eysvallpenkdknrypdilpydhsrvklsilpglflsd..yinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSV
| ... ..|....|..|| . ...|. |.. ..  . ..|  ||..|.|.|| .||   . ..|. |..| . ....  ||||.||||. |.|.|...  
wplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

SIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
 ..||| . |. ||.... | .|. .||||...| 
ylmleqlekelgvdleeavkllrsqRpgavqnpeq
subfamily_PTPN1_pd Subfamily PTPN1 1271-1512 6.5e-40 131.7 In-house 21-265 (290) alignment 
Range on Protein: 1271-1512
Range on HMM: 21-265/290.0
DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldmcqrEYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCY
| ...    . |.. ||..... ||  ||.|  . |      .||||. |.  . || .|..| |. |||  ||.|. . |  |.|||    | .|  |.
dfptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

QYWRES---EIVQFE--EYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQ-KIGGGPVVVHCSDTVSR
||| .    . ...|  .. || .| .. . |. |....   |   . ....|  | ||  |. . | . |. . .| .    .   ||.|.|||  . |
qywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

SGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLDQYSSIYE
|| .| |   | . ....    ||. .|   .|. . | . | ||    | 
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1270-1517 6.6e-40 131.8 In-house 21-258 (267) alignment 
Range on Protein: 1270-1517
Range on HMM: 21-258/267.0
EDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmcqreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECC
.   .|  ..|.|...||. .   |||.|. | |. .       |||| ||.||. |.|||. | |..||. ||...| |.||. ||.|  . .|     
tsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlf

YQyWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIfTEKGSSSWDVMQFQVTNWPTDGiirEPRTVLQVIDEV-IHRQQKIGGGPVVVHCSDTVSRSGVY
.   .  .  ....  |.    |. | |    ...   |  |. .|  .   .|  .    . .  |. .  .  . | . |. |.||.||| | ||| .
wP.Pkmgqakkyqdltvehslekeendyqiitlel.kfknesahnvtlyyykkwnint...nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtf

CSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMY
  .   ||. | |||.|.|.  . .|  ..| | |...|  |.|... |
lvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1254-1516 2.9e-39 129.6 In-house 17-234 (392) alignment 
Range on Protein: 1254-1516
Range on HMM: 17-234/392.0
CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLIT-NpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKV
 ||  | |... |   .    ...  |.|.  ||.|||  || .|. |   .   |. ...|.|| |....  ..|.| .|.|   .. |||.|. . .|
rhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid...dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenv

SAIVMLCGTEEDGqeccyqywreseivqfeeyfvkclsskdcngyierkfnifteKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIgGG
..|.|.   .|                                            || .   | ||..|.|| ... .   ..|..| ||     .    
ttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.th

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
|...|||  | |.||  |.   . ..|   .||||..   .|| .|  | | .||. ||  .  
pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1281-1514 1.3e-38 127.5 In-house 2-235 (237) alignment 
Range on Protein: 1281-1514
Range on HMM: 2-235/237.0
DNKAFNRFKNITVYDDNRITLITNPNLdmcqREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEI-
.||. ||. ||..|| .|. |  . .      .||||.|..|.    . .| || |.|..  |||.|. . | | |||| |  |  .. |..|| ...  
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

VQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWD-VMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVSRSGVYCSVSIALE
  .  . |     ..   |  | . ....        . |.| | ||  |. ..  ..|.   ..|.| ...   || ..|||  | |.|..  .   | 
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
|.| . |||...  .|.   .|  . | |||  |...|
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0051429 (Phosphotyrosine protein) phosphatases II 1313-1519 1.5e-38 128.3 In-house 5-226 (272) alignment 
Range on Protein: 1313-1519
Range on HMM: 5-226/272.0
EYINANYVHGYRE---KRAFIIAQSPMENTVRDFWKMiVDYKVSAIVMLCGTEEDGQECCYQYWR------------ESEIVQFEEYFVKCLSSKDCNGY
 ||||..| ||     ..... .. |...|..|||..  ......||.|...|| |.. |..||             . . . .  ..|..|| . .. |
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

IERKFNIFTE-KGSSSWDVMQFQVTNWPTDGIIREPrtVLQVIDEVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVD--------VFQ
| |.. .  . . . .  ||... |.||..|. .|.  .|...... .      ||||.||||  ..|.|... . . |..  .| .||        ...
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

VTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
. . .|.  |||| | .||  .||..  .|.
aveelraqrpgavqteeqylflyeallellr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1259-1516 1.6e-38 127.3 In-house 22-277 (439) alignment 
Range on Protein: 1259-1516
Range on HMM: 22-277/439.0
FEEQYKSLYTGE-DKSC--SIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAI
|.| .... . . | .|  |.   | ... ||.|... .|  |.||   | .   .  ||||||..|| ... .| .| | ..|. |||..... |.. |
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

VMLCGTEEdgqecCYQYWRESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKGSS--SWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIGGGP
|||.   |      |.||  .. | . .  |..    .   |. | |..| |. ..     |.||. . ||   .  .   ||. .  .   ..|   ||
vmltnlve.....sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygp

VVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
||||||  | |.|   .. ||||| |.|  ||.  . | .|. .   | .| ||  ||. .  
vvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
0042113 (Phosphotyrosine protein) phosphatases II 112-301 4.7e-38 126.4 In-house 1-233 (245) alignment 
Range on Protein: 112-301
Range on HMM: 1-233/245.0
CSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQreYINANYV---------------------------------------------HECCYQYW
.|... . || .||...|  ||..|. |   ..   .   ||||.||                                             .. |.|||
ysvallpenkdknrysdilpydhtrvklspdggdldsd..yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

RESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSI
 ......|....|..|| . ...|. |.. |. .... | .|.... ..|| .||   ....|.....| . ... ..|||.||||. |.|.|... . .
plgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

ALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHY
.||| ..|. |..... | .|. .||||.|..  .
mleqlekelgvsleeavkelrsqRpgavqtpsqyr
0045098 (Phosphotyrosine protein) phosphatases II 101-300 2.2e-37 124.4 In-house 14-261 (278) alignment 
Range on Protein: 101-300
Range on HMM: 14-261/278.0
YKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITlitnpnldmcqrEYINANYV------------------------------------------
.  | .|   ... .  ..|...||.|.|  || .|.             .||||.|.                                          
efllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-HECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLE----KSSSSWNVLQFQVTNWPTDGVIREP--RTVLQVIDEVIHRQQK----------
 .| |.||| |.. ..|....|..|| . .. |. |.. |.      ..  |..| ... ..||  ||  .|  . .|...... .....          
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

--IGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaEGVVDVFQVTKSVRRSKPG-AVTTLEIH
   .||||.||||  |.|.|... . . ||..  ||.||.... | .|. .|| ||..||  
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqy
0041856 (Phosphotyrosine protein) phosphatases II 1282-1520 3.6e-36 119.8 In-house 1-173 (182) alignment 
Range on Protein: 1282-1520
Range on HMM: 1-173/182.0
NKAFNRFKNITVYDDNRitlitnpnldmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCgteedgqecCYQYWRESEivqf
|.  ||...|  || .|               |||||.. |..  . ||..| |. .|| ||..|. ......||.|.         ...|| | .    
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell....

eeyfvkclsskdcngyierkfniftekgssSWDVMQFQVTNWPTDGIIRePRTVLQVIDEVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIALEQckae
                                 ..|.. ..|| .|.   ....|. |.||..      ||||.||||  |.|.|...   . ...    
..............................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....

GvVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKL
| |..... | ||. .||.|.|..||  .. .. ..|.|
g.vsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_PTPRN_pd Subfamily PTPRN 1263-1514 5.3e-36 118.8 In-house 35-288 (297) alignment 
Range on Protein: 1263-1514
Range on HMM: 35-288/297.0
YKSL--YTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLC
...|  |  |....... .|.|   || |..  ||..|..| .. .    . .||||  .      . |.| .|.|. .|| |||.|. .  |  ||.|.
wealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeas..aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

GTEEDGQECCYQYWRESEIVQFEEYFVKCLSSK-DCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIhRQQKIGGGPVVVHC
  ||.| . |..|| .     .. | |. .| .  |. |. | | .   . | .  | ||    ||  |.  .....|.    |  .  .    |.||||
rleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhc

SDTVSRSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
|| . |.|||. . . |..  |    .|.    . .|  .|| | | ||.  .. ..
sdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1283-1516 5.6e-35 115.4 In-house 57-281 (290) alignment 
Range on Protein: 1283-1516
Range on HMM: 57-281/290.0
KAFNRFKNITVYDDNRITLItnpnlDMCQREYINANYVHGYreKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE--SEIVQ
   ||.|...  |  |. |      |  . .|. ||||.|   |  ||..| ....|| |.|.|... ||.||||||   |||.  | ||. |   |.. 
fkknrykdvvcndktrvilk.....dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

FEEYFVKCLSSKDCNGYIE-RKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVihRQQkigGGPVVVHCSDTVSRSGVYCSVSIALeQCK
| |. | |  ..| .  |  . . .   .   .  .  ...  ||   .     ..|...  .  |.     ||||||||  . |.| . .. ..| |. 
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rka...sGpvvvhcsaGiGrtGtfvaievgl.qil

AEG-VVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
 .|  .|. .. ...|.|. ..|    ||  . |..  
ldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_PTPRD_pd Subfamily PTPRD 162-297 1.3e-34 114.8 In-house 133-267 (564) alignment 
Range on Protein: 162-297
Range on HMM: 133-267/564.0
CYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTVSRSGVY
| .|| |..  .|.|. |.  .... . |. |.| .. .|||.| .| ||. |.||  ||  .....|..|..| . . . . ||.|||||  | |.|..
chkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtf

CSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
. ... ||. |.|..||..|. | .|. ..  | | 
ividamlerikeektvDiyqyvkalrkqRnamVqte
0036282 (Phosphotyrosine protein) phosphatases II 1313-1512 7.9e-34 112.2 In-house 3-164 (174) alignment 
Range on Protein: 1313-1512
Range on HMM: 3-164/174.0
EYINANYVHGYREKRAFIIAQSPMEntvrdFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWREseivqfeeyfvkclsskdcngyierkfniftEKGSSS
 ||||.......  . .|. | |..     ||.|. .......|||.  .|.| . |..|| |                                . . .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredle

WDVMQFQVTNWPTDGIIREPRtVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKaEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
  ..|.. ..|| .|    .  .|.....| . ... .||||.||||  |.|.|. .   . | . . |..||.... ...|. .||.|.| .||  .|.
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1282-1511 1.4e-33 111.0 In-house 7-233 (239) alignment 
Range on Protein: 1282-1511
Range on HMM: 7-233/239.0
NKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEiVQ
||| ||. ||  || .|. |    |    . .||||.|.. |    .|.| .|  .| .  |||.|. . .   |||| |  |  .. |.||| .|   .
nkaknryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.sk

FEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIdEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKA
. .  |    ..    || | | .     .    | |...| ||  |. .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDVFQVTKSVRRSKPGAVTTLDQYSSIY
.  ||.|.  |..|  .|  | | .||  |.
qktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 162-300 1.5e-33 111.3 In-house 141-279 (298) alignment 
Range on Protein: 162-300
Range on HMM: 141-279/298.0
CYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVY
. .|| ..   .|.|  |. ||...   .| ||..|. .|.... .| |...|.||  || .. ..||.....|   ||. |  ||.|.||. | ||| .
yhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtf

CSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
. ..  ||. |.| ||||||| | .|...||||.| |  
iaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqY
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1282-1511 1.5e-33 111.0 In-house 8-234 (239) alignment 
Range on Protein: 1282-1511
Range on HMM: 8-234/239.0
NKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVHGYRE-KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEiVQ
||| ||. ||  || .|. |    |    . .||||.|.. |    .|.| .|  .| .  |||.|. . .   |||| |  |  .. |.||| .|   .
nkaknryanivtydhsrvvleklsn..dphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.sk

FEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIdEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKA
. .  |    ..    || | | .     .    | |...| ||  |. .   .|| .    | ..   |  | |.|||  | |.| .  .   | |.| 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVVDVFQVTKSVRRSKPGAVTTLDQYSSIY
.  ||.|.  |..|  .|  | | .||  |.
qktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 161-298 2.2e-33 110.7 In-house 130-267 (318) alignment 
Range on Protein: 161-298
Range on HMM: 130-267/318.0
CCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGV
 . .|| ... ..|..  |.  ...... |. |.| |. .....| .| |...|.||  ||  .. ..|... .| . ||| | ||.|||||  | | ||
kvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGv

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
.. |.| ||. |||..|||||. | .|. ..  | | .
fiavdillerikaealvDvfqtvkqlreqrnlmvqted
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 161-300 2.3e-31 103.9 In-house 92-231 (250) alignment 
Range on Protein: 161-300
Range on HMM: 92-231/250.0
CCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGV
 . |||      .| .  |. ||..    |. ||. .  .| ...  | |.. ..||  || .. ..||.....|   ||..| .||.|.||  |.||| 
tyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.. ..  ||. | | |||||.| | .|. .|.||..|| .
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqy
0049772 (Phosphotyrosine protein) phosphatases II 1266-1520 2.6e-31 104.9 In-house 30-282 (314) alignment 
Range on Protein: 1266-1520
Range on HMM: 30-282/314.0
LYTGEDKSCSIGYSEDNKAFNRFKNITVYDdNRITLitnPNLDMCQREYINANYVHGYrekRAFIIAQSPMENTVRDF----------WKMIV--DYKVS
| .  .... ... . |.  ||...|  .| ||  |   |.|..    ||||.||.|.   ..||..| |.|.|| ||          |.|..  |..| 
lsvlpeltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvr

AIVM---------------------LCGTEEDGqeccyQYWRESEIVQFEeyfvkclsskdcngyierkfNIFTEKGSSSWDVMQFQVTNWPTdGIIREP
 |||                     |..  . |      .. .... ...                    .. ...   .  ....  ...|  |    .
divmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelferlgikylripvpD.gsapll

RTVLQVIDEVIHRqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaeGVvDVFQVTKSVRRSKP-----GAVTTLDQYSSIYEVISMYLKL
. ...... .        ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .|.||  |.|.. .||| 
edfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
0037934 (Phosphotyrosine protein) phosphatases II 112-299 3.3e-31 104.1 In-house 2-230 (243) alignment 
Range on Protein: 112-299
Range on HMM: 2-230/243.0
CSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMcqREYINANYV----------------------------------------------HECCYQY
.||. .. |.  ||...|  ||..|. |      .     |||||..                                              .| |.||
fsiallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WReSDIiQYEEYFVKCLSSKDCNGYIERKFAVQLEK-SSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQK-------IGGGPVVVHCSDTVSR
|  ... .|....|..||.. ...|. |.. ..  . .  ...| ... ..||  ||  .|  .|. .|||.  ...        .||||.||||  |.|
wp.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

SGVYCSVSIALEQCkaeGvVDVFQVTKSVRRSKPG-AVTTLEI
.|...   . |...   | ||.... | .|. .|| ||.|.. 
tGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 162-298 4.6e-31 103.0 In-house 133-270 (319) alignment 
Range on Protein: 162-298
Range on HMM: 133-270/319.0
CYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSS-SWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGV
. .|| | .. .| .. |. .. .  ..|| ||. ..  .|   . .| .|| |.|| ..| .. ...|... .. . ..|   ||.|||||. | | | 
lkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
.. ....||. | |||.|||.. . .|  ..  | . |
fivldamlervkeegvlDvfstvsrlRtqRnimvqrpe
Y_phosphatase Protein-tyrosine phosphatase 161-299 2.1e-30 101.2 Pfam-A 83-225 (235) alignment 
Range on Protein: 161-299
Range on HMM: 83-225/235.0
CCYQYWR--ESDIIQYEEYFVKCL-SSK-DCNGYIERKFAVQLEKSSS-SWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTV
 | |||   |..  .|....|..  ..| |...|. ||. .. .|..| .  | |...||||  || ..|. .|..|..| ... .   ||||||||. |
kcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
.|.|......|.|||..||. |||.|. |..|...||.|..|| 
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq
Y_phosphatase Protein-tyrosine phosphatase 161-299 2.1e-30 101.2 In-house 83-225 (235) alignment 
Range on Protein: 161-299
Range on HMM: 83-225/235.0
CCYQYWR--ESDIIQYEEYFVKCL-SSK-DCNGYIERKFAVQLEKSSS-SWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQqKIGGGPVVVHCSDTV
 | |||   |..  .|....|..  ..| |...|. ||. .. .|..| .  | |...||||  || ..|. .|..|..| ... .   ||||||||. |
kcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
.|.|......|.|||..||. |||.|. |..|...||.|..|| 
gRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq
0043147 (Phosphotyrosine protein) phosphatases II 1312-1513 3.8e-30 100.3 In-house 5-156 (172) alignment 
Range on Protein: 1312-1513
Range on HMM: 5-156/172.0
REYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTeedgqeccyqywreseivqfeeyfvkclsskdcngyierkfniFTEKGSS
. ||||.|...|.  . ||. | |. ||. |||.|. ......||.|..                                            .. .   
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpell

SWDVMQFQVTNWPTDGIIrEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaEGVvDVFQVTKSVRRSKPGAVTTLDQYSSIY
.  ..|.. ..||  |    .. .|.... . .....  ||||.||||  |.|.|. .   . |     .|. ..... . ||. .||||.. .||  .|
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrfly

EV
. 
yf
DSPc_SM00195 161-300 7.5e-30 99.5 In-house 110-251 (263) alignment 
Range on Protein: 161-300
Range on HMM: 110-251/263.0
CCYQYWRES--DIIQYEEYFVKCLSSKDCN-GYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSR
 |..|| |.  .  ..... ||. . . ..  .| |.. .. |. . . .| |.|..|||  ||  ... ||... .| ......  ||.|||||. |.|
kcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.|......|.|.....|  ||.|.. |..| ..||.|.||| .
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqY
PTPc_SM00194 161-300 7.5e-30 99.5 In-house 110-251 (263) alignment 
Range on Protein: 161-300
Range on HMM: 110-251/263.0
CCYQYWRES--DIIQYEEYFVKCLSSKDCN-GYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSR
 |..|| |.  .  ..... ||. . . ..  .| |.. .. |. . . .| |.|..|||  ||  ... ||... .| ......  ||.|||||. |.|
kcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.|......|.|.....|  ||.|.. |..| ..||.|.||| .
tgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqY
0046846 (Phosphotyrosine protein) phosphatases II 1313-1518 9e-30 99.1 In-house 13-173 (176) alignment 
Range on Protein: 1313-1518
Range on HMM: 13-173/176.0
EYINANYVHGYRekraFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQFeeyfvkclsskdcngyierkfniftekgsss
 |||||.. |.|    .|. | |...|. ||..|. .....|.|.|.   | |.  |..|| | | ...                               
dyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............................

wdvmQFQVTNWPTDGIIREpRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSialeQCKAEGVVDVFQVTKSVRRSKP-GAVTTLDQYSSIY
    |.....||  |.    . .|......  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| .||  .|
....qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrfly

EVISMYL
|.. ..|
efellll
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 82-160 5.3e-29 95.9 In-house 2-80 (301) alignment 
Range on Protein: 82-160
Range on HMM: 2-80/301.0
MEELGNHVATCHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQREYINANYVHE
.|.||.|||..|||.||||||.|..||||||..|.||.|||.||||||||||||||.| ..||||.||||||||.|...
ledlgthvaakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidg
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1282-1519 1.4e-28 94.6 In-house 48-288 (305) alignment 
Range on Protein: 1282-1519
Range on HMM: 48-288/305.0
NKAFNRFKNITVYDDNRITLitNPNldmCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYW--RESEIV
..  ||.|..   |.||. |  ..       ||| ||||    . . || .|.|.|.|  ||| | .. || || |||   | | . |..|.  .. ...
eagknrykdvgcldnnrvkl..egp...wpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

QFEEY----FVKCLSSKDC------NGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVihrqqKIGGGPVVVHCSDTVSRSGVYC
.|||      ||. ||.        .  ...   .    |...  | ..   .||  |.     ..|... .      .   ||.|||||  . |.|   
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka.....rpskgpivvhcsagigrtgsvv

SVSIALEQCKAEGVV-DVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
 .   |.|  |  .. |  .. . .|  .  .. | .||  ...||  |..
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1321-1515 2.9e-28 93.4 In-house 230-435 (440) alignment 
Range on Protein: 1321-1515
Range on HMM: 230-435/440.0
HGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEdgqECCYQYWR-ESEIVQFEEYFVKCLSSKDCNGYIERKFNIFTEKgsSSWDVMQFQ
.||  | ||| .| |.. || |||... ||..|.|.||   ..     |  ||  ..  | |  . |    |.. |    | ...   .     .. ||.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyke..evheirqfe

VTNWPT----DGIIREPR---TVLQVIDEV----IHR---QQKIGG-GPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
|  |||    ||.  . .   .|||..| .    | |   | . |   |..|||   .  |||.|.|   ||| . .| .||||  . .| |.|  | ||
vqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptl

DQYSSIYEVIS
 .|   | ...
tdyllcykllt
subfamily_Ptp69D_pd Subfamily Ptp69D 161-299 3e-28 93.8 In-house 132-274 (307) alignment 
Range on Protein: 161-299
Range on HMM: 132-274/307.0
CCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSS-----SSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTV
 | .|| . |..||..  ||. |.. .. ||.|.. |   | .      | .|.|.. |.|.   | . .|..|..|..| . ...   .|.|||||  |
kcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
.|||.. .... |.|.|||  ||.|...| .|. ..  |. || 
grsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleq
0049260 (Phosphotyrosine protein) phosphatases II 1319-1512 4.9e-28 93.1 In-house 1-144 (152) alignment 
Range on Protein: 1319-1512
Range on HMM: 1-144/152.0
YVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWreseivqfeeyfvkclsskdcngyierkfniftekgssswdvmQF
...||. ...||..| |..||. |||.|. ......||||.  .|.| ..|.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QVTNWPTDGIIREPRTVLQVIDEVIHRqQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaeGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
. ..|| .|    .  .|.... . .. ..  ||||.||||  |.|.|...   . |        |..... . ||. .||||.. .|.  .||
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1280-1525 9.5e-28 92.1 In-house 39-286 (307) alignment 
Range on Protein: 1280-1525
Range on HMM: 39-286/307.0
EDNKAFNRFKNITVYDDNRITLITnpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESE--
. |   ||.... . | .|| . .    |    .|| |||.    . . || || |.|||. .|| |... || ...||| . | ..  | |||   |  
santdknryqdvkcqdkgrivvkf....dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

IVQFEE----YFVKCLSSKDCNGyIERKFNIF---TEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQqkiggGPVVVHCSDTVSRSGVYCS
   | |      |. | .|      |   |.     . .. |  . ..| .|||  |. .   | . ... |   .      |||||||  | |||   .
klvfgeapntisvanlgakklap.dedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGtiva

VSIALEQ-CKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVIS-MYLKLH-STYA
.|.  ..  . .   |. .. . .|  .. |. |  ||  .. |.   .|.|.  ||.
islvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketye
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1274-1514 9.7e-28 91.6 In-house 29-265 (281) alignment 
Range on Protein: 1274-1514
Range on HMM: 29-265/281.0
CSIGYSEDNKAFNRFKNITVYDDNRITLIT-NPNLDmcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQY
|..     |.  ||. || . |  |. |    || .    .|| |||..    || .|..| | ..|  |||.|| . . .||||||   |  .| | .|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnkn..stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WRE-S-EIVQFEEYFVKCLSSKDCNGYIERKFNIFTEkGSsSWDVMQFQVTNWPTDGIIREPRTVLQVIdevihRQQKIGGGPVVVHCSDTVSRSGVYCS
.   .   .||... |.   |   .  .  ..|.  | |  .  . ..   .||   .      .|...     |. .    | |.|||  | |||   .
fprnahcclqfdklsvsyedstvnkslvttrlnlsye.ge.trlithwlwkewpdwqvpessevmlkil.....rkirarstppvihcsagvgrsgtlma

VSIALEQCKAE-GVVDVFQVTKSVRRS-KPGAVTTLDQYSSIYEVI
| |||.  ..   . |. |.   .| . .  .| ||.||  |..|.
veialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_PTPRK_pd Subfamily PTPRK 161-300 4.3e-27 89.7 In-house 127-266 (314) alignment 
Range on Protein: 161-300
Range on HMM: 127-266/314.0
CCYQYWRESDIIqYEEYFVKCLSSKDCNGYIERKFAVQL--EKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKiGGGPVVVHCSDTVSRS
 |..|| |   . |..  |......  . .. | |.|.    . .    | ||| ..||. .|  . ...|... .| . |.. . |..|||||    |.
kClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
|... ..| |.  . |||||||.. |..| .|.  | | | .
Gtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqy
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 160-299 7.2e-27 89.3 In-house 131-272 (297) alignment 
Range on Protein: 160-299
Range on HMM: 131-272/297.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIR--EPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSR
. | .|| .. . .. .  |. || ....|.|.|.. |. .|. .   | |.| ..||.. | |  . ...|..|.|| .  ..   ||..|||.  | |
kkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
 ||....   . . | |  ||.|.. | .|...|  | | | 
tgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeq
subfamily_PTPRA_pd Subfamily PTPRA 160-300 9.2e-27 88.8 In-house 141-284 (330) alignment 
Range on Protein: 160-300
Range on HMM: 141-284/330.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQ----LEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGgPVVVHCSDTV
| |.||| .  .. | .  |.   .. .. |  ||| ||      .  .|  | ||  | ||  ||  ||. .|... .| . .|. .| |.|||||  |
ekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGv

SRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
 |.| .. ..  ||. |||..||||.. |..|  .|  | |.| .
GrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqy
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1281-1521 3.1e-26 87.1 In-house 42-274 (288) alignment 
Range on Protein: 1281-1521
Range on HMM: 42-274/288.0
DNKAFNRFKNITVYDDNRITLItnpnlDMCQrEYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWrESEIVQ
.| . .|..|.   |  |. |      | ..  ||.|| |   . || .| ||.|.. |.  .|||...  |  |||||   | |.|   .|.  |.. .
anptrdryenlprcditrvkls.....ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyf.PsklGe

FEEYFVKCLSSKDCNGYIERKFNIFTEKGSSSWDVMQ----FQVTNWPTDGIIREPRTVLQVIDEViHRQQKigggPVVVHCSDTVSRSGVYCSVSIALE
   .   |   |. .  |..  .. . . |   .  .      . .|. ||.  .  . |.... . .  ||    |.|||.|  | |.|    . ||||
karigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililiale

QCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLH
. . .  . . .. .. | ..  |..|  ||  .. ..  .| |.
slrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
0051082 (Phosphotyrosine protein) phosphatases II 1313-1513 8.7e-26 85.7 In-house 4-148 (151) alignment 
Range on Protein: 1313-1513
Range on HMM: 4-148/151.0
EYINANYVHGYrekraFIIAQSPMEntvrDFWKMIVDYKVSAIVMLCGTEEDGqeCCYQYWRESEivqfeeyfvkclsskdcngyierkfniftekgsss
 |||..|| |.     ... . |..    ||.... ......||.|...|| |   |..|..| .                                   
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

WDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaegvVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
 .|.......||. |.   . .||........     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. .|.  .. 
ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

V
.
a
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1311-1519 2.8e-25 84.0 In-house 45-260 (290) alignment 
Range on Protein: 1311-1519
Range on HMM: 45-260/290.0
QREYINANYVHgYREKRAFIIAQSPMEN-------TVRDFWKMIVDYKVSAIVMLCGTEEDGQE----CCYQYWRES--EIVQFEEYFVKCLSSKDCNGY
. .|| ||.|  . .  ..|. ||| |.       |. .|| |. . ||  .||||  ||  ..     | .| .||  |...|.   ||| |    .. 
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

IERKFNIFTEKGsSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQqkiggGPVVVHCSDTVSRSGVYCSVSIALEQCK-AEGVVDVFQVTKSVRRS
..|.  .  ...   . |   .. .| .  . ....|.|..|. |  ..      ||.||| | .||| .  .. ..       .| | . .| |..|. 
etRelvvkfdde.eeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkq

KPGAVTTLDQYSSIYEVISMYLK
.  |.|.  ... .  .| ....
ralaitsalelafvdagivllai
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 162-299 5.4e-25 82.9 In-house 129-265 (315) alignment 
Range on Protein: 162-299
Range on HMM: 129-265/315.0
CYQYWRE--SDIIQYEEYFVKCLSSKDCNGYIERKFavQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRqQKIGGGPVVVHCSDTVSRSG
| ||| .  .| ... .. |. || . . . . ||.   . || .| .| ||| |.||  || ..  ..|..| ||    ..    ...||||  | |.|
crqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
| .|.   ..| | . .||||.. | .|. .|  | | | 
vvisidevvaqikrtrsvdvfnfvknlrakrpylvqteee
PTPc_DSPc_SM00012 1415-1514 1.5e-24 81.6 In-house 2-103 (105) alignment 
Range on Protein: 1415-1514
Range on HMM: 2-103/105.0
VMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
|.....|.||  |. .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..|.|.|...| . ||.||. |..|...||.|.|..||. .|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VI
..
al
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1308-1507 1.8e-24 81.0 In-house 71-270 (301) alignment 
Range on Protein: 1308-1507
Range on HMM: 71-270/301.0
DMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYW--RESEIVQFEEYFVKCLSSKDC--NGYIERKFN
.  .|  | ||..    . . ||..|.|..||  ||| |.| |.|  ||||. . |. .| | .|   . || .. . . .|  ...    .  ..|...
vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtle

IFTEKG-SSSWDVMQFQVTNWPTDGIIREPRTVLQVIdEVIHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVT
.    |  ..  |. .| ..|.  |. .    . ... |.. . .|    |.|||||. . ||  . .  .   . .|.  ... .  | .|  .  .| 
vedstgkfatrtvthyqysewtdrgvPkshaelfdlm.elvkksek....PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvq

TLDQY
|  | 
tnsql
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1282-1518 2.4e-24 80.5 In-house 55-289 (305) alignment 
Range on Protein: 1282-1518
Range on HMM: 55-289/305.0
NKAFNRFKNITVYDDNrITLITNPNldMCqrEYINANYVHGY-REKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES--EI
... ||.... . | . . .. .|.   .  .|| ||||      .. || || |...|. .|| |... ||  ||||| | | |.  | |||  .  | 
aitknryqdvpcqdqs.avkldkps..ps..dyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

VQFEE-YFVKCLS-SKDCNGYIERK--FNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVihRQQKIgggPVVVHCSDTVSRSGVYCSVSIA
...     |. .| ||  .   | .     .|  |. .  | ..| |.||  |.     | |...  .  |  |.   |.|||||  . |.|   ..   
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai..rgskv...pivvhcsagigrtgtivaieyi

LEQCKA-EGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
||.      .  . .. |..|  .  .. .  ||  |. |.  |.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 162-298 3e-24 80.0 In-house 128-263 (515) alignment 
Range on Protein: 162-298
Range on HMM: 128-263/515.0
CYQYWRE--SDIIQYEEYFVKCLSSKDCNGYIERKFAVqlEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGgGPVVVHCSDTVSRSG
| .|| .  .| ... .. |. .| . | | | ||. |   |.. |  | ||. |.||  || .. ...|..| ||   ....   |...|||  | | |
cgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
|..|.   . . |   .||||.. . .|. .|  | | |
vvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqe
subfamily_PTPN6_pd Subfamily PTPN6 160-299 7.4e-24 79.3 In-house 138-285 (306) alignment 
Range on Protein: 160-299
Range on HMM: 138-285/306.0
ECCYQYWRESDI-IQYEEYFVKCLSSKDCNGYIERKFAVQ-LEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIG---GGPVVVHCSDT
| |..|| ..    .| .. |...|.|. . || |.. |.  .|.... .| |.. ..||  || ..| .||. ...| ..|...     ||.|||||. 
ekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaG

VSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLEI
. | | .  . | |.. . .|.   .|. .. ||||. . | | | . 
iGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqq
0044763 (Phosphotyrosine protein) phosphatases II 1298-1520 2.5e-23 78.1 In-house 6-173 (178) alignment 
Range on Protein: 1298-1520
Range on HMM: 6-173/178.0
RITLITNpnLDMCQREYINANYVHGYrekraFIIAQSPMentvRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIvqfeeyfvkclsskdcngy
|  |..    ...  .||||... ..     ..... |.     |..... ......||.|... | |.. |..|| |..                    
rvllsnl..eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

ierkfniftekgssswdvmqFQVTNWPTDGIIREP-RTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGVvDVFQVTKSVRRS
                    .|. ..|...    . .  .. . | |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrer

KPgAVTTLDQYSSIYEVISMYLKL
.| .|.. .|.  .||. ...|| 
Rp.ivpnpgqlrqLyefelrllke
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1262-1429 3.9e-23 76.8 In-house 12-180 (297) alignment 
Range on Protein: 1262-1429
Range on HMM: 12-180/297.0
QYKSLYTgEDKSCSIGYSEDNKA--FNRFKNITVYDDNRITLITNPnldmCQREYINANYVHGYREKR--AFIIAQSPMENTVRDFWKMIVDYKVSAIVM
.. .|.  | .. |   .  | .   ||...|  .||.|. |   .     .|.||||.||    |.    .|.|| |...|| |||.....  | .|||
ekdllld.eargesfssakrnsslrknryrdilatddtrvkllrvi....terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivm

LCGTEEDGQECCYQYWRESE--IVQFEEYFVKCLSSK--DCNGYIERKFNIFTEkgSSSWDVMQFQVTNWPTDGII
..  .|||.. |. || ...    .  .. |. |||   . .  |  .....    | |  |   |  .||  |. 
vaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvp
subfamily_PTPRG_pd Subfamily PTPRG 160-302 7.7e-23 75.5 In-house 131-278 (563) alignment 
Range on Protein: 160-302
Range on HMM: 131-278/563.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQL---EKSS---SSWNVLQFQVTNWPTDGVIREPRTVLQVIDEViHRQQKIGGGPVVVHCSD
. | .|| . . ..|..  |.  ...    | .|.. ..    .| .   .  .| |.. |.||  ||   .  ||. .     . .|   ||.||||| 
rkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsa

TVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
 |.|.|.|. ..  |.| ..| .|.||.. | .|  ..  |.| |  ..
GvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYif
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 160-298 1.1e-22 75.3 In-house 115-253 (283) alignment 
Range on Protein: 160-298
Range on HMM: 115-253/283.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSS-SSWNVLQFQVTNWpTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRS
. | ||| .   ..| |. |        | .| ... .. . |. |.  .  .|| .| ..     .   |  .. ||  |..   ||.||||| .. |.
ikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrt

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
.|....| .... ..| |||||.| | .|  ...|| ||.
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtld
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 161-301 2.5e-22 74.3 In-house 131-269 (288) alignment 
Range on Protein: 161-301
Range on HMM: 131-269/288.0
CCYQYWRESDI-IQYEEYFVKCLSSKDCNGYIERKFAVQleKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSRSG
 | .|| ..|   .| .  |. ..||. . ...||. ..  |. .  .. |.| . || .|| .  . .|.... |   .|.   ||..||||. | |.|
kCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtg

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHY
.. ..  .... ..| ..||. . . .|....  | ||. . 
tFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYe
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1282-1520 2.6e-22 73.9 In-house 43-278 (312) alignment 
Range on Protein: 1282-1520
Range on HMM: 43-278/312.0
NKAFNRFKNITVYDDNRITLITNPNLdmcqreYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE-SEIVQ
 | .||. || ..|  |.||  . |.      || ||.|.       |...|.|.|||.  ||.. .    ..|..|||  ||| | | .|  .   .|.
fkdlnrypniqcwdrgrftlagdenf......yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

FEEYFVK---C----LSSKDCNGYIERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEViHRQQKigggPVVVHCSDTVSRSGVYC---S
.|.. |    |    .  |  .    | ...          . ..| . ||  |.     | |...  | ....|    ||. |||  | |.|  .   |
ledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.kkdkk....pviahcsagvgrtgtlalies

VSIALEQCKAEGVVDVFQVtksVRRSKPGAVTTLDQYSSIYEVISMYLKL
.  || . . . | |.| .   .|. .  .| .. ||     ..  .|  
miaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvleflys
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 162-300 4.6e-22 73.5 In-house 126-265 (281) alignment 
Range on Protein: 162-300
Range on HMM: 126-265/281.0
CYQYWRESD-IIQYEEYFVKCLSSKDCNGYIERKFAVqLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGV
|..|| . .  ..| .. || ..... . |||||| .  ..|. . .| |.. |.||  ||  ... .|.  .|| . ..|    |.|.|||  | |.|.
ChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGt

YCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLEIH
| ..  ......||   .|| .| ...|...   | |.  .
yialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy
subfamily_PTPN3_pd Subfamily PTPN3 161-296 1.3e-21 71.8 In-house 125-260 (280) alignment 
Range on Protein: 161-296
Range on HMM: 125-260/280.0
CCYQYWRE-SDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEViHRQQKIGGGPVVVHCSDTVSRSG
 |.||| | .| ..| |. ||| ...  . |. |.. .. .... . ..||.| ..||  ||  ..  .|.....| .....    |||||||  . |.|
kChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
|.  . .||    |.  | . .. . .|  .   | |
vlilletalalieaaepvypldivrtmrdqramlvqt
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1274-1518 1.9e-21 71.3 In-house 27-270 (285) alignment 
Range on Protein: 1274-1518
Range on HMM: 27-270/285.0
CSIGYSEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHG-YREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQY
|.    | |  .||. .. . .. |. |         .|.|| |....   ... ..| .| |. .|. |||.|| . |.. ..|||   | | | |  |
ctytayeanpdlnryadvrcieetrvvl......knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WRE--SEIVQFEEYFVKCLSSKD--CNGYIERKFN-IFTEKGSSSWDVM-QFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSG
. |   |.|.| .| .     |.    | |   .  | ||  ||    | . ||  || .    . | ....   | . . |    |..||||  | |. 
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrta

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
 .  .  |  .   .  ...... . .|  .  || .  |.  .| |.  |.
tfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_ptpA1_pd Subfamily ptpA1 1243-1476 2e-21 71.2 In-house 9-254 (418) alignment 
Range on Protein: 1243-1476
Range on HMM: 9-254/418.0
SMEELGNHVATCHSngFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNpnLDMCQREYINANYVHGYREKrAFIIAQSPMENTVR
|. .| ||.   |    .|... |         | |  . | . ||. ||   .  |. |      |    .||||||. |   |  || .| |. ||. 
siynlknhikcihk..ikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkki..qdkegsdyinanyidgaypk.qfictqgplpntia

DFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESE-IVQF----------EEYFVKCLS-SKDCNGYIERKfNIFTEKGSSSWDVMQFQVTNWPTDGII
|||.|. . ..  ||||    |. .  | .|| |     ||            | |. .   .| .  |  . ||       . |. |.|   ||   | 
dfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitr.nirltfegetrditqyqyegwpdhnip

REPRTVLQVIDEVIHRQQKIG-----GGPVVVHCSDTVSRSGVYCSVSIALE
   . . |..  .  ||..|        |..||||  | |.| .|.  | ..
dhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 160-298 2.1e-21 71.4 In-house 130-275 (325) alignment 
Range on Protein: 160-298
Range on HMM: 130-275/325.0
ECCYQYWRES--DIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-----GGGPVVVHCS
. | .|| .   .  ..    ||  . ..   |. |.. |.  |   .  | |||.  |.  || . | |.. ... | . ....     . .|..||||
drcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

DTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
. | |.||. |.  ||..   |  ||.|.. | .|. .|  | | .
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd
subfamily_CG7180_pd Subfamily CG7180 161-299 2.5e-21 70.6 In-house 125-278 (296) alignment 
Range on Protein: 161-299
Range on HMM: 125-278/296.0
CCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLE----------KSSSSWNVLQFQVTNWPT-DGVIREPRTVLQVIDEVIHRQQKI----GGG
 . .|| .    || | ||. ...|       |.| .. .           .     |..||.| |.  | |     ......  |   ..|.      |
mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg

PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEI
||||..|| .||||||... ..||. . |. ||||.  | .|||.|. | . | 
PvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenvee
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 92-300 2.7e-21 70.4 In-house 17-225 (392) alignment 
Range on Protein: 92-300
Range on HMM: 17-225/392.0
CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLIT-NpnlDMCQREYINANYVH----ECCYQYWRESDIIQYEEYFVKCLSSKD
 ||  | |... |   .    ...  |.|.  ||.|||  || .|. |   .   |. ...|.|| |..    | .|   .   .   ....   .  . 
rhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid...dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenv

CNGYIERKFaVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIgGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSV
.   .  |.  . .|  .   | ||..|.|| ..| .   ..|..| ||     .    |...|||  | |.||  |.   . ..|   .||||..   .
ttiamvtkl.kegdkgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtni

RRSKPGAVTTLEIH
|| .|  | | | .
rrkrpymvqtkeqy
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 160-302 3.3e-21 70.9 In-house 138-282 (319) alignment 
Range on Protein: 160-302
Range on HMM: 138-282/319.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQL-EKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGG-GPVVVHCSDTVSR
. | |||     |..|.. ||  | .... |. |.. .    |     .. ||    ||  ||   |  ...... | | ..|  .  ..|||||  | |
dkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
.|||  . . |.. | |  |||... . .|. ..  |  |  ...
tGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf
subfamily_egg_pd Subfamily egg 1272-1519 3.9e-21 70.0 In-house 30-271 (307) alignment 
Range on Protein: 1272-1519
Range on HMM: 30-271/307.0
KSCSIGYSEDNKAFNRFKNITVYDDNRITLitNPNLDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDgqECCYQ
.|    .|..|.   | | .   |  |..|  . .  .   ..| ||.|.|      ||.||.|. ||| |||.|.   .|  ||||  . |   | |  
islttaasdnnlekarskrvhckdssrvkl..elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWRE--SEIVQF--EEYFVKCLSSKDCNGYIerkFNIFTEKGsSSWDVMQFQVTNWPTDgiIREPRTVLQVIDevIHRQQKIGGGPVVVHCSDTVSRSGV
||    |. ...    . ...|  ..    .   |..   |     |  .  .  |  |  ...   |   .   . |. .    ||||.. . ||....
ywpkaesdslvtvpGslrienlkvdskadpl...frvtklkl.vGgddeerflehwqgd..vnnssdvysplr..vlrklrnlskpvvvqdilGvskaat

YCSVSIALEQCKAEGVV--DVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
  .. ||| .     ..   | .  . .|. .. .| .  .|  .| .. ....
lvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 160-302 4.7e-21 70.5 In-house 102-246 (284) alignment 
Range on Protein: 160-302
Range on HMM: 102-246/284.0
ECCYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQL-EKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGG-GPVVVHCSDTVSR
. | |||     |..|.. ||  | .... |. |.. .    |     .. ||    ||  ||   |  ...... | | ..|  .  ..|||||  | |
dkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
.|||  . . |.. | |  |||... . .|. ..  |  |  ...
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 161-307 6.1e-21 69.7 In-house 114-262 (274) alignment 
Range on Protein: 161-307
Range on HMM: 114-262/274.0
CCYQYWRESDII----QYEEYFVKCLSSKDCNGYIERKFAVQLEKSssSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI--GGGPVVVHCSDT
 | .|. ..  .    .|..  .|  . ...|.|  ||. ..  ..  . .|  .  |.||   . ....|.|....|| . ...     .|||||||  
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEihYYQAMDR
. | |.. ..|||. | ..|.||||....  .|  . | | | |   |. . |
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtse..qyelihr
subfamily_PTPRB_pd Subfamily PTPRB 162-298 1.2e-20 68.7 In-house 136-272 (293) alignment 
Range on Protein: 162-298
Range on HMM: 136-272/293.0
CYQYWRES-DIIQYEEYFVKCLSSKDCNGYIERKFAVQLekSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQ-QKIGGGPVVVHCSDTVSRSG
| .|| .  . ..| .  |. ..... . .. |.....   .... .| |.. | ||  ||  ...|.|. . .| ... ..   .|.|||||  | |.|
CeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
.. ..   |.. . | .||.| .  ..|...   | | .
tfialdrllqaieeedyvdifgivaelReeRnllvqtek
PTPc_DSPc_SM00012 208-298 1.9e-20 68.4 In-house 2-94 (105) alignment 
Range on Protein: 208-298
Range on HMM: 2-94/105.0
VLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIG-GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLE
| ....|.||  || .|.  .|.....| . ..|.. ..|||||||. |.|.|... ..|.|.|...| . ||.||. |..|...||.|.|.|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 161-300 2.3e-20 67.7 In-house 133-268 (315) alignment 
Range on Protein: 161-300
Range on HMM: 133-268/315.0
CCYQYWRESDIIqYEEYFVKCLSSKDCNGYIERKFAVQLEksSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGgGPVVVHCSDTVSRSGV
 . .|| . ..| | .. |   | .  . |  | ..|  .  .   .|.|...| ||. || .   .....|  |   ...   |..|||||. | |.| 
kaekywpdkkvi.yGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGt

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.....  |.| .|| ..||... . ||. . ..| ..| .
fitldavldqaeaenaidvynfitgvrqnrikmvqvaeqy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1282-1520 4.1e-20 66.8 In-house 47-346 (350) alignment 
Range on Protein: 1282-1520
Range on HMM: 47-346/350.0
NKAFNRFKNITVYDDNRITLITNP------NLDMCQREYINANYVHGY----REKRAF--IIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECC
  | ||.|||  |. .|. |  ..      .  .   .||||||..      . .  |  | .|.|. .|| ||.|.|.  ||  |..|    | . | |
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

YQYWRESEIV----QFEEYFVKCLSSKDCNGY---------------------IERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVID---E
|.||.| ..     ....   .  . .|.  |                      . .    |   |  . |.|.|| ||.  ... .|. .||...   .
yrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevknd

VIH------RQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCK---------------AEgVVD-VFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
.|         ..  . |..||||  | | |.....   |.. .               |. . | .... . .|. .   | .|||.  ||| .  | .
liddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDlisiivnelrkqrismvqnldqfifiYeallfyfa

L
|
L
subfamily_PTPN12_pd Subfamily PTPN12 162-299 5.1e-20 66.5 In-house 125-265 (290) alignment 
Range on Protein: 162-299
Range on HMM: 125-265/290.0
CYQYWRES--DIIQYEEYFVKCLSSKDCN-GYIERKFAVQLEksSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkIGGGPVVVHCSDTVSRS
| .|| |.  . ....|. |.. . | .. ... | ..|. .  . | .| ||. |.||  || . . ..|..|..| ..|.     |.|||||  | | 
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrt

GVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLEI
|. ... .. |. ||| .   .|||..  ..|. .. .| | | 
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeq
subfamily_PTPN23_pd Subfamily PTPN23 162-298 1.2e-19 65.2 In-house 125-267 (288) alignment 
Range on Protein: 162-298
Range on HMM: 125-267/288.0
CYQYW--RESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIH---RQQKIGGGPVVVHCSDTVS
. .||  .. .  ..... | . | .. . ..||.. .. ....   .|   |.|.||  ||   | |.||..||| .    .|.    |.|||||  | 
vdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvg

RSGVYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLE
|.||.. |  |...  | .|..|. || . .|. .   | . |
RtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqeke
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1271-1523 2.2e-19 64.0 In-house 43-290 (302) alignment 
Range on Protein: 1271-1523
Range on HMM: 43-290/302.0
DKsCSIgySEDNKAFNRFKNITVYDDNRITLitnpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTV---RDFWKMIVDYKVSAIVMLCGTEEDGQe
.| |..    .| ..|. ... ..|.|.. |      .... .|.||  |.    .|  |.|| |  ...    .||.|. . |.  .|.| |.||  . 
ek.Cka..fkknlkknqsedvpildsnlvkl......eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.

CCYQYWR--ESEIVQFEEYFVKCLSSKDCNGYI-ERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEViHRQQKIGGGPVVVHCSDTVSR
   ...     . ..... ||     .  ..   .    .. |  | |  ..   .|||. . .  .  .. . . .| . ..  .  ..|.     . |
tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGR

SGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKLHST
 |.  .. .|.|. ...  . . .. ||.|  .| || .|.|| |.| .. .|.| . |
agafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvt
0051429 (Phosphotyrosine protein) phosphatases II 152-298 4.3e-19 64.7 In-house 6-212 (272) alignment 
Range on Protein: 152-298
Range on HMM: 6-212/272.0
YINANYVH-----------------------------------------------ECCYQYWR------------ESDIIQYEEYFVKCLSSKDCNGYIE
||||..|                                                . |..||             .   | |  ..|..|| . .. || 
yiNardvggygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyil

RKFAVQLE-KSSSSWNVLQFQVTNWPTDGVIREPrtVLQVIDEVIHrqqkigGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVD--------VFQVT
|.. . |. . . .  |.... |.||..|| .|.  .|...... .      ||||.||||  ..|.|... . . |..  .| .||        .... 
rellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeav

KSVRRSKPGAVTTLE
. .|.  |||| | |
eelraqrpgavqtee
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 161-300 7.3e-19 62.8 In-house 105-253 (270) alignment 
Range on Protein: 161-300
Range on HMM: 105-253/270.0
CCYQYWRES--DIIQYEEYFVKCLSSK--DCNGYIERKFAVQleKSSSSWNVLQFQVTNWPTDGVIREPR------TVLQVIDEV-IHRQQKIGGGPVVV
 | .|| ..  . ...|. ..| |...    .||| ..  ..  ..... ... |. ..|| .|| ||.        .|... .|  .....  ..|..|
kCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

HCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
|||. | |.|.   . ||..  . .. ||| .. . .|. ..  | . |  
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqy
subfamily_PTPN9_pd Subfamily PTPN9 162-294 7.6e-19 62.8 In-house 127-273 (297) alignment 
Range on Protein: 162-294
Range on HMM: 127-273/297.0
CYQYWR--ESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQ------------KIGGGPV
| |||   | . ... .. |. .. .  . | .|.. ..  | . | .|  ||.. ||  || ..  ..|.|...| ..|             .. | |.
cgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPi

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAV
|||||  . |.| .... |.|.. . .|.|||... | .|  .  ..
vvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsi
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1257-1375 2.7e-18 60.6 In-house 27-142 (310) alignment 
Range on Protein: 1257-1375
Range on HMM: 27-142/310.0
NGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldmCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIV
.|.  ||. | . .| | .    ...   ||. .. . |. |. |  .        .|| ||||.    . .|| .| |.. |. |||.|| . .  .|.
eglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidks...ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MLCGTEEDGQECCYQYWRE
.|| . |.|.  |  ||  
llckvgeegrpkcvgywps
subfamily_PTPN13_pd Subfamily PTPN13 162-305 4.4e-18 60.5 In-house 119-265 (273) alignment 
Range on Protein: 162-305
Range on HMM: 119-265/273.0
CYQYWRES---DIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkiGGGPVVVHCSDTVSRS
| .|| ||    .  .. . |. |  .. .|.  |..||.  .|. | .| ... ..||  || ...  .||.. || . |.    ||.|||||  . ||
chrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrs

GVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE--IHYYQAM
|.. .. ..|.  . .  .|| .. ...|. . | | | .  |  |.|.
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
0041856 (Phosphotyrosine protein) phosphatases II 120-303 6.2e-18 60.5 In-house 1-163 (182) alignment 
Range on Protein: 120-303
Range on HMM: 1-163/182.0
NKAFNRFKNITVYDDNRitlitnpnldmcQREYINANYVHEC------------------------------------CYQYWResdiiqyeeyfvkcls
|.  ||...|  || .|               |||||..  .                                    ...||                 
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywp................

skdcngyierkfavqlekSSSSWNVLQFQVTNWPTDGVIRePRTVLQVIDEVIHrqqkiGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGvVDVFQVT
                  .    ...|.. ..|| .||   ....|. |.||..      ||||.||||  |.|.|...   . ...    | |..... 
..................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeav

KSVRRSKPGAVTTLEIHYYQ
| ||. .||.|.|.. ... 
klvrsrRpgmvitpnqyffl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1325-1513 6.8e-17 56.3 In-house 3-199 (199) alignment 
Range on Protein: 1325-1513
Range on HMM: 3-199/199.0
EKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDgQECCY-QYWR--ESEIVQFEEYFV--KCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQ
 .| .| .| |. .|. |||.|. .     |||.   . . .|. |  ||   ||   ..    |  |....|         .   |    |. .. ..|
gqrryiatqhplretmadfwqmvwetgsghivmvnddqkn.keadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

VTNWPTDGIIREPRTVLQVI--DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEV
 | |           |  |.   || .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1326-1513 8.2e-17 56.0 In-house 3-198 (198) alignment 
Range on Protein: 1326-1513
Range on HMM: 3-198/198.0
KRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDgQECCY-QYWR--ESEIVQFEEYFV--KCLSSKDCNGYIERKFNIFTEKGSSSWDVMQFQV
.| .| .| |. .|. |||.|. .     |||.   . . .|. |  ||   ||   ..    |  |....|         .   |    |. .. ..| 
qrryiatqhplretladfwqmvwetgsghivmvnddqkn.keadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TNWPTDGIIREPRTVLQVI--DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEV
| |           |  |.   || .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|..|  ||.|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 160-298 1.1e-16 55.8 In-house 85-226 (237) alignment 
Range on Protein: 160-298
Range on HMM: 85-226/237.0
ECCYQYWRESDI-IQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWN-VLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKI-GGGPVVVHCSDTVS
. |..|| ..|    |  . |     ..   |  | . .. . .      . |.| | ||  || ..  ..|.   ..|.| ...   || ..|||  | 
lkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvg

RSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLE
|.|..  .   | |.| . |||...  .|.   .|  . | .
rtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkd
0036282 (Phosphotyrosine protein) phosphatases II 159-298 3e-16 55.0 In-house 51-157 (174) alignment 
Range on Protein: 159-298
Range on HMM: 51-157/174.0
HECCYQYWREsdiiqyeeyfvkclsskdcngyierkfavqlEKSSSSWNVLQFQVTNWPTDGVIREPRtVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRS
.. |..|| |                                ... . ...|.. ..|| .||   .  .|.....| . ... .||||.||||  |.|.
lykcinywpe...............................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRt

GVYCSVSIALEQCKaEGVVDVFQVTKSVRRSKPGAVTTLE
|. .   . | . . |..||.... ...|. .||.|.| .
Gtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 161-300 7.6e-16 53.0 In-house 92-229 (239) alignment 
Range on Protein: 161-300
Range on HMM: 92-229/239.0
CCYQYWRESDiIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIdEVIHRQQKIGGGPVVVHCSDTVSRSGV
 |.||| .|   .| .  |    ..    || | | .     .    | |...| ||  || .   .|| .    | ..   |  | |.|||  | |.| 
kchqywpdst.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.  .   | |.| .  ||.|.  |..|  .|  | | | .
flvidamlrqakkqktvdifnyvkairedrphmvqtseqy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 161-300 7.7e-16 53.0 In-house 93-230 (239) alignment 
Range on Protein: 161-300
Range on HMM: 93-230/239.0
CCYQYWRESDiIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIdEVIHRQQKIGGGPVVVHCSDTVSRSGV
 |.||| .|   .| .  |    ..    || | | .     .    | |...| ||  || .   .|| .    | ..   |  | |.|||  | |.| 
kchqywpdst.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr.rkitkdslpgarpwvihcsagvgrtga

YCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIH
.  .   | |.| .  ||.|.  |..|  .|  | | | .
flvidamlrqakkqktvdifnyvkairedrphmvqtseqy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1332-1508 9.1e-16 52.2 In-house 96-278 (302) alignment 
Range on Protein: 1332-1508
Range on HMM: 96-278/302.0
AQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE--SEIVQFEEYFVKCLSSK-DCNGYIERK-FNIFTEK-------GSSSWDVMQFQV
   |  .|.  .| .| .|.|. .| ||.  ||... | .|. .   . ..| .| || .| | | . . ..| |...| .             |  .. 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWPTDGIIREPRTVLQVIDEVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYS
. ||  |  .|. | |...      ...     |.||||  | |.|   ..   .. |. . | |. .. . ||. . ||| . .|  
sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 162-297 1.4e-15 51.6 In-house 128-265 (439) alignment 
Range on Protein: 162-297
Range on HMM: 128-265/439.0
CYQYWRESDIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSS--SSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSG
 |.||  .. . | .  |..    .   |. | | |  |. .      ||||. . ||   |  .   ||. .  .   ..|   ||||||||  | |.|
sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtG

VYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
   .. ||||| |.|  ||.  . | .|. .   | .|
tiialdialeqlklenkvdikgivkvlrkqrkqmvqal
subfamily_PTPN1_pd Subfamily PTPN1 161-298 2.4e-15 51.0 In-house 112-258 (290) alignment 
Range on Protein: 161-298
Range on HMM: 112-258/290.0
CCYQYWRES---DIIQYE--EYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQ-KIGGGPVVVHCSDT
 |.||| .    . ...|  .. || .| .. . |. |.. ..  |.  . ..|.|  | ||  || . | . |. . .| .    .   ||.|.|||  
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VSRSGVYCSVSIALEQCKAEGV---VDVFQVTKSVRRSKPGAVTTLE
. ||| .| |   | . ....    ||. .|   .|. . | . | .
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtad
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1311-1428 2.5e-15 50.9 In-house 12-126 (130) alignment 
Range on Protein: 1311-1428
Range on HMM: 12-126/130.0
QREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGqeccyQYWRESEIVQ-FEEYFVKCLSSKDCNGYIERK-FNIFTEK
. .||||..|      . .. .| |. .|  |||||...  |  .|.|   ||.      .|| .|| .. .||  .  |. .|   .|. . ..|  . 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdrdefknikasnleiesdl

GSSSWDVMQFQVTNWPTDGI
  |   .  ||..|||.|| 
neshqaltmfqisnwpsdgt
subfamily_CG42327_pd Subfamily CG42327 1299-1441 4e-15 50.3 In-house 45-189 (319) alignment 
Range on Protein: 1299-1441
Range on HMM: 45-189/319.0
ITLITNPNLDmcQREYINANYVHGYREKRA-FIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRESEIVQ----FEEYFVKCLSSKD
..|   .. |  . ||..|.|| ||.. .. .| || ..|..  |||... . .   || |.   | | . | .|.  .|  .    . .. |     . 
vvlqrigddd..kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrev

CNGYIERKFNIFTEKGSSSWDVMQFQVtNWPTDGIIREPRTVLQVIDE
 . |.   . .   ... | ..  .   .|.  ..  |..... .. |
kdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamlle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1281-1429 4.1e-15 50.1 In-house 95-236 (244) alignment 
Range on Protein: 1281-1429
Range on HMM: 95-236/244.0
DNKAFNRFKNITVYDDNRITLITNpnlDMcQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGqeccyQYWRESEIVQ
.|   ||      .| ||. |       |    |||| .|        .|..| |. .|  |||||... .|  .|.|   ||.      .|| .|| ..
nnswknregaglpfdfnrvplskg...sm.gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpdseple

-FEEYFVKCLSSKDCNGYIE-RKFNIFTEKGSSSWDVMQFQVTNWPTDGII
 .||     |. .|    |   ...| ..   |   .  ||..|||.||  
wyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgtt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 81-159 4.4e-15 50.3 In-house 3-85 (290) alignment 
Range on Protein: 81-159
Range on HMM: 3-85/290.0
SMEELGNHVATCHS---NGFEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQREYINANYVH
 ....|..||. |.   .||..|.|.| .|| ...  .| ...||  |||.|| |||||||||   ..   |. ||||| |..
pvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 187-324 4.6e-15 49.9 In-house 74-205 (440) alignment 
Range on Protein: 187-324
Range on HMM: 74-205/440.0
CNGYIERKFAVQLEksssSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSV
 . ||.  .   .|    |  . |..   ||  || .    ||..|..| . |.| | ||..||||  ..|.||  .|   | ..|    .|.| . .|.
dsdyinasyingie....srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsm

RRSKPGAVTTLEIhyYQAMDRLLVLPLLIGLLLVLVND
| ..|  | | |   |  .   ..  ||.|  |.| .|
rnnrpqmvqtpeq..yafvheavlegllcgdtliledd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 147-297 1.2e-14 49.2 In-house 98-245 (290) alignment 
Range on Protein: 147-297
Range on HMM: 98-245/290.0
MCQREYINANYVHECCYQYWRES--DIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSsSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQqkigg
.|..|  .||  .. | .| .||  ......   ||| |    .. ..|.  |. ..    . |   .. .| .  | ....|.|..|. |  ..     
lcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdde.eeftvtHsllkgWnklnvqedtktllsliqkvkask.....

GPVVVHCSDTVSRSGVYCSVSIALEQCK-AEGVVDVFQVTKSVRRSKPGAVTTL
 ||.||| | .||| .  .. ..       .| | . .| |..|. .  |.|. 
tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsa
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1284-1516 1.2e-14 48.7 In-house 49-277 (303) alignment 
Range on Protein: 1284-1516
Range on HMM: 49-277/303.0
AFNRFKNITVYDDNRITLitnpnldmCQREYINANYVHGYREKRAfIIAQSPMENTVRDFWKMIVDYKVSAIVML-CGTEEDGQECCYQYWRESEIVQFE
  ||| .. . |  .. |        ..  || |.|..   .|.| |..| |.  |  |||.||.. ||  ...|   .| |     . . |. ....||
dknrfvdvicldhskvkl........sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

EYFVKCLSSKDCN---GYIERKFNIFTekGSSSWDVMQFQVTNWPTDGIIRE--PRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQ
| ...    |  .   |.  .   .    |.    .   .  .|| . |  .  |. | |. .     ..   . | |      . |.| ..    |   
ersirvgefkrvelgdgwvlkvlsvsn..gdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

CKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
 ..|   .|. .. . ||  .  ||  | |.| .| ... 
lhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 79-159 2.6e-14 48.1 In-house 3-83 (305) alignment 
Range on Protein: 79-159
Range on HMM: 3-83/305.0
PVSMEELGNHV---ATCHSNGFEEQYKSLYTGeDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVH
......| ...    . ...|.|.||||||.  ..|. .| .| ||| ||.|.||..||.|| | ....||  ...||||.||.
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvd
0048076 (Phosphotyrosine protein) phosphatases II 1398-1517 2.6e-14 48.6 In-house 30-142 (145) alignment 
Range on Protein: 1398-1517
Range on HMM: 30-142/145.0
IERKFNIFTEKGSSSWDVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiALEQCKAEGvVDVFQVTKSVRRSK
| . .|. .|.   .  ..|.. ..||  |.   ....|.... . . ...  ||||.||||  |.|.|...    |.  .. .| |..... . ||.  
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqr

PGAVTTLDQYSSIYEVISMY
||||.. .|.  .||.. ..
pgavpnpgqlrflyefelel
0049772 (Phosphotyrosine protein) phosphatases II 104-302 4e-14 48.5 In-house 30-270 (314) alignment 
Range on Protein: 104-302
Range on HMM: 30-270/314.0
LYTGEDKSCSIGYSEDNKAFNRFKNITVYDdNRITLitnPNLDMCQREYINANYVHECcYQY------------------------WRESD---------
| .  .... ... . |.  ||...|  .| ||  |   |.|..    ||||.||. .  ..                        || .          
lsvlpeltilvadlflnrdknryldilpad.nrvil...pglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdi

-----------------------IIQY---------------EeyfvkclsskdcngyierkfAVQLEKSSSSWNVLQFQVTNWPTdGVIREPRTVLQVI
                       ...                .                     .. ...  . .....  ...|  |    .. .....
vmsrdevladelsrLdaAlgKtpllildgngneptaadlellk....................eelydpelferlgikylripvpD.gsaplledfdefl

DEVIHRqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCkaeGVvDVFQVTKSVRRSKP-----GAVTTLEIhYY
. .        ||||.|||.. ..|.|... . . . ..   || .. .. . ||.  |     |.. .||  |.
efieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleq.ye
subfamily_PTPRN_pd Subfamily PTPRN 161-298 6.4e-14 46.3 In-house 141-279 (297) alignment 
Range on Protein: 161-298
Range on HMM: 141-279/297.0
CCYQYWRESDIIQYEEYFVKCLSSK-DCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIhRQQKIGGGPVVVHCSDTVSRSG
 |..|| .     |. | |. .| .  |. |. | | ..  ..| .  | ||    ||  ||  .....|.    |  .  .    |.|||||| . |.|
qckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn.ksyrGrscpivvhcsdGaGrtG

VYCSVSIALEQC-KAEGVVDVFQVTKSVRRSKPGAVTTLE
||. . . |..  |    .|.    . .|  .|| | | .
vyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkd
subfamily_CG42327_pd Subfamily CG42327 1451-1519 7.7e-14 46.1 In-house 247-316 (319) alignment 
Range on Protein: 1451-1519
Range on HMM: 247-316/319.0
GGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLK
 ||.|||||| | |.|.  .  ||... .     ||. |.  |||| .  || | .||  || |.|.| |
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
0051082 (Phosphotyrosine protein) phosphatases II 153-306 1.5e-13 46.1 In-house 6-148 (151) alignment 
Range on Protein: 153-306
Range on HMM: 6-148/151.0
INANYVHE----------------------------------CCYQYWRESDiiqyeeyfvkclsskdcngyierkfavqlekssssWNVLQFQVTNWPT
||..|| .                                   |..|..| .                                    .||......||.
infsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg...................................ievlhipildwpd

DGVIREPRTVLQVIDEVIHrqqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaegvVDVFQVTKSVRRSKPGAVTTLEIHYYQAMD
 |.   . .||........     ..|||.||||  ..|.|. . . . |..      |..... . .|.. ||.|.. . ...| ..
pglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 174-302 2.1e-13 44.9 In-house 125-250 (267) alignment 
Range on Protein: 174-302
Range on HMM: 125-250/267.0
YEEYFVKCLSSKDCNGYIERKFAVQLeKSSSSWNVLQFQVTNWPTDGVIrepRTVLQVI-DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQCK
|..  |.    |. | |    . ... |  |. ||  .   .|  .      .  |. .   . . | . |. |.||.||| | ||| .  .   ||. |
yqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnintnn...kpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerak

AEGVVDVFQVTKSVRRSKPGAVTTLEIHYY
 |||.|.|.  . .|  ..| | |.| . |
tegvsdifdflrkirsqriglvdtkeryiy
0043147 (Phosphotyrosine protein) phosphatases II 187-302 3.9e-13 45.0 In-house 54-152 (172) alignment 
Range on Protein: 187-302
Range on HMM: 54-152/172.0
CngyierkfavQLEKSSSSWNVLQFQVTNWPTDGVIrEPRTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALeqckaEGVvDVFQVTKSV
.          .. ..  . ...|.. ..||  ||   .. .|.... . .....  ||||.||||  |.|.|. .   . |     .|. ..... . |
l..........lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalv

RRSKPGAVTTLEIHYY
|. .||||.. . ...
rekRpgavqnpsqyrf
subfamily_PTPN14_pd Subfamily PTPN14 160-297 4.8e-13 43.8 In-house 133-282 (300) alignment 
Range on Protein: 160-297
Range on HMM: 133-282/300.0
ECCYQYWRES----DIIQYEEYFVKCLSSKDCNGYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVI----HRQQKI----GGGPV
| ...|. ..    . ...... |    |.| . .| ... ..   |.   .|. .| |.|| .|| ..... |. ..||     . ....       ||
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTL
.||||. | |.||   . . ..  . . ..|. .| . .|. .   | ||
lvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl
0048179 (Phosphotyrosine protein) phosphatases II 1347-1512 6.1e-13 44.2 In-house 25-139 (144) alignment 
Range on Protein: 1347-1512
Range on HMM: 25-139/144.0
IVDYKVSAIVMLCGTEEDGQECCYqywreseivqfeeyfvkclsskdcngyierkfniftekgssswdVMQFQVTNWPTDGIIREPRTVLQVIDEVIHRQ
. ........ |. . |   . ..                                            ..|.. ..||  |.   .  .|.... . . .
lkklgittvinlteeyepeflere............................................giqylhlpwpDhgvpdllellleflefieeal

QkiGGGPVVVHCSDTVSRSGVYCSVSIALeqckAEGvVDVFQVTKSVRRSKPGAVTTLDQYSSIYE
.   ||||.||||  |.|.|...   . .     .| ...... . ||.  ||||.. .|.  ..|
e..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
fn3 Fibronectin type III domain 831-917 1.6e-12 40.5 Pfam-A 1-82 (85) alignment 
Range on Protein: 831-917
Range on HMM: 1-82/85.0
SPVTSLSVSNVSTTGITVNWTIP-SSDNYVTYYTISYTPSCPQSssVNQTVSVAPHqsttTYSYTLIGLYSGMNYTITVRAGNVLGGS
|... ||||.|..| .|..|. | . .  .|.|.. | ..  ..  . ....| ..    |.|.|| ||  |..|...|.| |  |..
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprt....ttsvtltgLkpgteYefrVqavngageg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1286-1377 2.2e-12 41.0 In-house 52-157 (349) alignment 
Range on Protein: 1286-1377
Range on HMM: 52-157/349.0
NRFKNITVYDDNRITLITNPN-----------LDMC-QREYINANYVHGY--REKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQ
||.|.|  |.  |. |   ..            | .   .||||||..      .. .|  | |.  || ||.|.|.  .|  .. |   .| . | |..
nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdi

YWRESE
||.| .
ywqels
fn3 Fibronectin type III domain 572-646 3.4e-12 39.5 Pfam-A 2-79 (85) alignment 
Range on Protein: 572-646
Range on HMM: 2-79/85.0
APSSLTEVSKTATTITVSWTAL--GSSDADGYVVNVTNDTDT--VQTVQVEGSSNdTLKVEGLEVNTTYSITVRAYQQL
||. |.  . |.|..|.||..   |... .|| | . .....   ....|..... .....||. .|.|...|.|. . 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
subfamily_PTPRD_pd Subfamily PTPRD 79-159 4.4e-12 40.4 In-house 4-85 (564) alignment 
Range on Protein: 79-159
Range on HMM: 4-85/564.0
PVSMEELGNHVATCHSN---GFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVH
|....|| .|||  ..|    |||.||.. .|.  ...    . ||| ||..||. || .|. | . ..    . .||||....
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfid
0048076 (Phosphotyrosine protein) phosphatases II 197-299 8.2e-12 40.5 In-house 36-131 (145) alignment 
Range on Protein: 197-299
Range on HMM: 36-131/145.0
VQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSGVYCsvsiALEQCKAEGvVDVFQVTKSVRRSKPGAVTT
.  |..  . ...|.. ..||  ||   ....|.... . . ...  ||||.||||  |.|.|...    |.  .. .| |..... . ||.  ||||..
ltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpn

LEI
 . 
pgq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 162-306 1.3e-11 38.7 In-house 136-277 (290) alignment 
Range on Protein: 162-306
Range on HMM: 136-277/290.0
CYQYWR--ESDIIQYEEYFVKCLSSKDCNGYI-ERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVihrqqKIGGGPVVVHCSDTVSRS
| ||.   | ... . |. | |  ..| .  |  . ..|.  .|  .  .  ...  ||   |     ..|...  .     .   ||||||||  . |.
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril.....rkasGpvvvhcsaGiGrt

GVYCSVSIALeQCKAEG-VVDVFQVTKSVRRSKPGAVTtLEIHYYQAMD
| . .. ..| |.  .|  .|. .. ...|.|. ..|  ..| |   ..
Gtfvaievgl.qilldGkeldlldlvralrnsrlnsvq.vdiqylalve
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1244-1333 1.5e-11 38.3 In-house 7-94 (95) alignment 
Range on Protein: 1244-1333
Range on HMM: 7-94/95.0
MEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcqreYINANYVHGYREKRAFIIAQ
.  .  ||   |||    |....||.      . ..| || |   ||| ||  ||  |..| |. . |     |||| .| ||  | ..| ||
vsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsd.....yinacfvdgyarkncyiaaq
0049260 (Phosphotyrosine protein) phosphatases II 159-302 1.6e-11 39.6 In-house 48-141 (152) alignment 
Range on Protein: 159-302
Range on HMM: 48-141/152.0
HECCYQYWresdiiqyeeyfvkclsskdcngyierkfavqleksssswnvlQFQVTNWPTDGVIREPRTVLQVIDEVIHRqQKIGGGPVVVHCSDTVSRS
...|.||.                                           |.. ..|| .||   .  .|.... . .. ..  ||||.||||  |.|.
klkceqyi...........................................qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRt

GVYCSVSIALeqckaeGVVDVFQVTKSVRRSKPGAVTTLEIHYY
|...   . |        |..... . ||. .||||.. .  ..
gtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrf
0048179 (Phosphotyrosine protein) phosphatases II 185-299 1.9e-11 39.4 In-house 48-133 (144) alignment 
Range on Protein: 185-299
Range on HMM: 48-133/144.0
KdcngyierkfavqleksssswnVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkiGGGPVVVHCSDTVSRSGVYCSVSIALeqckAEGvVDVFQVTK
                       ..|.. ..||  ||   .  .|.... . . ..   ||||.||||  |.|.|...   . .     .| ...... .
e......................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleeala

SVRRSKPGAVTTLEI
 ||.  ||||.. . 
lvrsrrpgavpnpgq
0046846 (Phosphotyrosine protein) phosphatases II 152-298 3.9e-11 38.5 In-house 14-160 (176) alignment 
Range on Protein: 152-298
Range on HMM: 14-160/176.0
YINANYVHECCY-----------------------------------------QYWREsdiiqYE---Eyfvkclsskdcngyierkfavqleksssswn
|||||..  ...                                         .|| |     .|                                   
yinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.....leklgi...............................

vlQFQVTNWPTDGVIREpRTVLQVIDEVIHRQQKigGGPVVVHCSDTVSRSGVYCSVSialeQCKAEGVVDVFQVTKSVRRSKP-GAVTTLE
  |.....||  ||    . .|......  ....  ||||.||||  ..|.|...        .. |  ..|... . ||. .| |||.| |
..qylhlpwpDhgvpdl.elllellefirealke..ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1274-1362 6.7e-11 36.3 In-house 29-120 (347) alignment 
Range on Protein: 1274-1362
Range on HMM: 29-120/347.0
CSIGYSEDNKAFNRFKNITVYDDNRITLItNPNLDMCQ----REYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTE
..    | . . || |.  . |. |. |    . ....      |||| ...    .. .|..| |. .||||||||.   ||. .| .    
ftsvewekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1331-1503 7.3e-11 36.6 In-house 39-206 (255) alignment 
Range on Protein: 1331-1503
Range on HMM: 39-206/255.0
IaqspmenTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRE--SEIVQFEEYFVKCLSskDCNGYIERKFNIFTEKG--SSSWDVMQFQVTNWPTD
.       ||  |...||  | . .||||  .|.|.| | .|.     |  ....  | .      .  . |  .| .. |      .|  .. . |.  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiek

GIIREPRTVLQVIDEVihRQQKigggPVVVHCSDTVSRSGVYCSVSIALE-------QCKaEGVVDVFQVTKSVRRSKPGAVTT
   ...| .|...  |  |. |    .||||||  . ||  .  . ..         . .  . .|  .. . .| ....|. |
naPelareilnilkvv..rdsk....svvvhCstGiGrsaafvlaelvyqkmirsldtte.tveldylslleelrskrkraiht
subfamily_PTPRG_pd Subfamily PTPRG 81-159 8.1e-11 35.8 In-house 2-85 (563) alignment 
Range on Protein: 81-159
Range on HMM: 2-85/563.0
SMEELGNHVATCHSNG---FEEQYKSLY---TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQrEYINANYVH
 ..|. .||| .|..|   |.|....|    . .|  ..    ..||  ||  ||. ||  |..|   |. .    .||||||..
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyid
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 162-296 3.4e-10 34.2 In-house 122-262 (287) alignment 
Range on Protein: 162-296
Range on HMM: 122-262/287.0
CYQYWRESDI-IQYEEYFVKCLSSKD--CNgYIERKFAVQLEKSSSSWNVLQFQVTNWPTDGVIRE----PRTVLQVIDEVIHRQQKIGGGPVVVHCSDT
||.|| | .  ..   | |  |. .    . |  | . .   ..  .  | |... .|| ...        | ||.| . .  ...  . ||.|||..  
cykywPerevPmrvGGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

VSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
. |||.. .. . ... .  | ||| .|   .|  . . | .
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqa
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 82-159 4.4e-10 34.0 In-house 4-80 (287) alignment 
Range on Protein: 82-159
Range on HMM: 4-80/287.0
MEELGNHVATCHS---NGFEEQYKSLYT--GEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLItnpnldMCQREYINANYVH
.|..|. ||. |    .||..|.. |     ....  .. ...||  ||...| |.|..|. |        .. .|||| .. 
vekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfid
subfamily_PTPN6_pd Subfamily PTPN6 77-159 4.9e-10 33.9 In-house 8-90 (306) alignment 
Range on Protein: 77-159
Range on HMM: 8-90/306.0
TLPVSMEELGNHVATCHSNGFEEQYKSLYTGE---DKSCSIGYSEDNKAFNRFKNITVYDDNRITLItnpNLDMCQREYINANYVH
..   ..|| ..  . . .||||....| . |     | . |   .||  ||.|||  .|..|..|    . .. . .||||||..
eieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyik
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 93-159 4.9e-10 34.0 In-house 13-78 (281) alignment 
Range on Protein: 93-159
Range on HMM: 13-78/281.0
HSNGFEEQYKSLYT-GEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVH
...|| |.|..|.  | |.. .  ....|.  ||..||. ||  |...  | .    . .|||||.| 
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvp
subfamily_hpo-7_pd Subfamily hpo-7 1336-1505 5.1e-10 33.7 In-house 43-214 (263) alignment 
Range on Protein: 1336-1505
Range on HMM: 43-214/263.0
MENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWR--ESEIVQFEEYFVKCLSSKDcnGYIERKFNIFT--EKGSSSWDVMQFQVTNWPTDGIIRE
. .|.  |...||  | . .||||  .|.|.| | .|.     |  ....  | .  ...    . .  ..    ..     .| ... . |.     ..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PRTVLQVIDevIHRQQKigggPVVVHCSDTVSRSGVYCSVSIALE------QCKAEGVVDVFQVTKSVRRSKPGAVTTLD
.| .|....  . |. |    ..|||||  . ||  .  . ..        .    . .|  .. . .| |...|. |  
areilnilk..varnsk....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPm
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1282-1410 9.8e-10 32.4 In-house 34-159 (332) alignment 
Range on Protein: 1282-1410
Range on HMM: 34-159/332.0
NKAFNRFKNITVYDDNRITLITNPnldmCQREYINANYVHGYREKRAFIIAQSPMEN-TVRDFWKMIVDYKVSAIVMLCGTEEDG-QECCYQY-WRESEI
|  .||   . ..| .|. |  .      . .. ||..| || .| |.|.||.|... |   ||.|. . | | |...   .|   ... |.   |  | 
nmdmnriphlycfdhsrvelapqd....gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfek

VQFEEYFVKCLSSKDCNGYIERKFniFTEKGS
  . |.  | |   . .  | |||  . ||.|
sflhefgaksleecelkakicrkf..wpekrs
subfamily_PTPRB_pd Subfamily PTPRB 78-159 1.8e-09 32.1 In-house 5-88 (293) alignment 
Range on Protein: 78-159
Range on HMM: 5-88/293.0
LPVSMEELGNHVATCHS---NGFEEQYKSLY-TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVH
 |...|.. .||.. ..    .| |.|..|   |.|.....  .. |.| ||..||  || .|. | .    |  . .||||||..
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyip
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 79-159 4.8e-09 30.7 In-house 4-85 (319) alignment 
Range on Protein: 79-159
Range on HMM: 4-85/319.0
PVSMEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNldMCQREYINANYVH
.. ..|| ... . .|.|   .|...| | ...... .    |.||  ||..||  ||  |..| . ..  . . .||||... 
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfid
0044763 (Phosphotyrosine protein) phosphatases II 149-298 5e-09 31.5 In-house 17-158 (178) alignment 
Range on Protein: 149-298
Range on HMM: 17-158/178.0
QREYINANYVHECC------------------------------------YQYWRESDIiqyeeyfvkclsskdcngyierkfavqleksssswnvlqFQ
  .||||... .                                      ..|| |.                                         .|
rsdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeag.......................................iq

VTNWPTDGVIREP-RTVLQVIDEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQckaeGVvDVFQVTKSVRRSKPgAVTTLE
. ..|...    . .  .. . | |.. ..  ||||.||||  |.|||. .   . ...    |. ..... . ||. .| .|.. .
ylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 87-159 5.5e-09 30.5 In-house 13-84 (288) alignment 
Range on Protein: 87-159
Range on HMM: 13-84/288.0
NHVATCHSNGFEEQYKSL-YTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVH
..      .||.|.|.||   ...|| ..|    |.  ||..||  || .|. |   .. .  . .||||.|..
akksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyid
subfamily_eak_pd Subfamily eak 1290-1424 6.1e-09 29.7 In-house 59-190 (332) alignment 
Range on Protein: 1290-1424
Range on HMM: 59-190/332.0
NITVYDDNRITLITNpnlDMCQREYINANYVHGYREKRAFIIAQSPMENTVRDFWKMIVDYKVSAIVMLCGTEEDGQECCYQYWRES--EIVQFEEYFVK
.|  || . . | .     . .  ||||  .      | .|..  . |. |  ||.|... |  |||.|    | . |   .|. .   | ..|  . |.
kivpydrylvrltss...qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

CLSSKDCNGYIERKFNIftEKGSSSWDVMQFQVTNWP
. .    | .  |.. .  .||  .  |. ..|  | 
rkefvkrniletrllel..skGnethrvlhykvfGwt
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 200-296 6.4e-09 29.7 In-house 184-273 (302) alignment 
Range on Protein: 200-296
Range on HMM: 184-273/302.0
EKSSSSWNVLQFqvTNWPTDGVIREPRTVLQVIDEVIHRQQKigggpVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.|   . ..|.|  . ||  |  .|. | |...      ...     |.||||  | |.|   ..   .. |. . | |. .. . ||. . ||| .
kkvkktvdilaf..sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqd
subfamily_Ptp69D_pd Subfamily Ptp69D 94-159 1.3e-08 29.3 In-house 21-85 (307) alignment 
Range on Protein: 94-159
Range on HMM: 21-85/307.0
SNGFEEQYKSLY-TGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVH
  |... |..|  .  |||....  ..|.  ||...|. .|..|. | . .  .  . .||||....
dfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfik
fn3 Fibronectin type III domain 936-1012 2.4e-08 27.2 Pfam-A 3-85 (85) alignment 
Range on Protein: 936-1012
Range on HMM: 3-85/85.0
PDNVTFIPVNN---NLTWNEVDcsERNGLITGYTVMISNS-----SITYNLTSTERYIILNDLVFGPEYIISVAAVNSVGRGPFS
| |.....|..   .|.|.. .  ...| ||||.|  ...     . ......|..  .|..|  | || ..|.||| .| ||.|
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1259-1518 3.8e-08 26.3 In-house 43-309 (346) alignment 
Range on Protein: 1259-1518
Range on HMM: 43-309/346.0
FEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKN--ITVYDDNRITLITNPNLDMCQREYINA--NYVHGYREKRAFIIAQSP-MEN--TVRDFWKMIVDYK
  |....    . ..|   | |.   .||  .  .   . . |||        |   |..    |.  .. .. .|.|| | |||   | ||| || . .
ttedfeankvrnregcpkiydenrvqlnrpghedvnyinasvitlkdvsrrmacvpayvhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeq

VSAIVMLCGTEEDGQECCYQYWRESEIVQFEEYFVKCLSSKDCNGY-IERKFNIFTEKGSSSWdVmqFQVTN-WPTDGIIREPRT--VLQVIDEVIHRQQ
.  . ..   .   .     .  |    |.   ..      |  |   |   ... |  | |  .   ||    |   . . |.|  ....| .    .|
ihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsv.i..cqvhhhapwkhlqqppktlpiikmihqflsekq

KIGGGPVVVhCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYL
    |  ||       |.  .     |..|       ..... |.... .||.| .. ||.||| ..  |.
vqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_CG42327_pd Subfamily CG42327 243-299 6e-08 26.7 In-house 246-303 (319) alignment 
Range on Protein: 243-299
Range on HMM: 246-303/319.0
GGGPVVVHCSDTVSRSGVYCSVSIALEQCKAE-GVVDVFQVTKSVRRSKPGAVTTLEI
  ||.|||||| | |.|.  .  ||... .     ||. |.  |||| .  || | | 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 197-301 6.8e-08 26.9 In-house 167-266 (307) alignment 
Range on Protein: 197-301
Range on HMM: 167-266/307.0
VQLEKSSSSWNVLQFQVTNWPTDGVIREPRTVLQVIDEVIHRQQkigggPVVVHCSDTVSRSGVYCSVSIALEQ-CKAEGVVDVFQVTKSVRRSKPGAVT
.... .. |  . ..| .|||  || .   | . ... |   .      |||||||  | |||   ..|.  ..  . .   |. .. . .|  .. |. 
lkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiq

TlEIHY
| |. |
t.eaqy
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 82-162 9.3e-08 26.2 In-house 7-89 (95) alignment 
Range on Protein: 82-162
Range on HMM: 7-89/95.0
MEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDMCQREYINaNYVHECC
.  .  ||   |||    |....||.      . ..| || |   ||| ||  ||  |..| |. . |  .  ...  |    |
vsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvd.gyarknc
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 233-301 1.3e-07 26.0 In-house 124-193 (199) alignment 
Range on Protein: 233-301
Range on HMM: 124-193/199.0
DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLEiHY
 || .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|. ||
revskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslq.hy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 233-301 1.3e-07 26.0 In-house 123-192 (198) alignment 
Range on Protein: 233-301
Range on HMM: 123-192/198.0
DEVIHRQQKIGGGPVVVHCSDTVSRSGVYCSVSIALE---QCKaEGVVDVFQVTKSVRRSKPGAVTTLEiHY
 || .. ..    ||.|||||    .||. .. | .    . |   |||.|.|.| .|... | ...|. ||
revskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslq.hy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 203-270 2.8e-07 24.6 In-house 212-288 (350) alignment 
Range on Protein: 203-270
Range on HMM: 212-288/350.0
SSSWNVLQFQVTNWPTDGVIREPRTVLQVID---EVIH------RQQKIGGGPVVVHCSDTVSRSGVYCSVSIALEQ
|  . |.|.|| ||.  ... .|. .||...   ..|         ..  . |..||||  | | |.....   |..
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsd
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1453-1514 2.8e-07 24.7 In-house 230-291 (297) alignment 
Range on Protein: 1453-1514
Range on HMM: 230-291/297.0
PVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVI
...||||  | ||||     . |.. . . . ||  . . .|  ..  | ||.|.  .|...
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 81-160 3.1e-07 24.9 In-house 13-94 (298) alignment 
Range on Protein: 81-160
Range on HMM: 13-94/298.0
SMEELGNHVATCHSNGFEEQYKSLYTGED----KSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVHE
 ...| .   . .  |...... | ....    .. ... ...||  ||. .|  .|  |. | ..   .  . .|||| ..| 
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflha
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 80-158 3.3e-07 24.7 In-house 2-82 (318) alignment 
Range on Protein: 80-158
Range on HMM: 2-82/318.0
VSMEELGNHVATCHSNG---FEEQYKSLYTGEDKSCSI-GYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYV
.|.|.| .||.  ...|   ..|.|. |   |... |.   .. ||| ||. ||. ||. |. | .    .  . .||||||.
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmle..geegsDyinanyi
DSPc_SM00195 97-159 3.5e-07 25.2 In-house 2-63 (263) alignment 
Range on Protein: 97-159
Range on HMM: 2-63/263.0
FEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVH
..|....| . . .|... .  . ||. ||.||| .||..|. | ....    . .||||||. 
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyik
PTPc_SM00194 97-159 3.5e-07 25.2 In-house 2-63 (263) alignment 
Range on Protein: 97-159
Range on HMM: 2-63/263.0
FEEQYKSLYTGE-DKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmCQREYINANYVH
..|....| . . .|... .  . ||. ||.||| .||..|. | ....    . .||||||. 
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyik
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 185-269 3.7e-07 23.8 In-house 197-290 (349) alignment 
Range on Protein: 185-269
Range on HMM: 197-290/349.0
KDCNGY-IERKFAVQLeKSSSSWNVLQFQVTNWPTDGVIREPRTVLQV-------IDEVIHR--QQKIGGGPVVVHCSDTVSRSGVYCSVSIALE
|.|.    . . |..| .... . .||.|| ||.  ... .| ..||        ||.   |   ..    ...||||    |.||.. . . |.
knCdlpddddddaill.avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1455-1520 3.9e-07 24.4 In-house 2-67 (69) alignment 
Range on Protein: 1455-1520
Range on HMM: 2-67/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKL
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |    .|  |.. .   |||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl
subfamily_PTPRK_pd Subfamily PTPRK 89-158 4.6e-07 24.0 In-house 16-79 (314) alignment 
Range on Protein: 89-158
Range on HMM: 16-79/314.0
VATCHSNGFEEQYKSLYTGedksCSIGYSEDNKAFNRFKNITVYDDNRITLITNpnLDMCQREYINANYV
. .... || |.|.||. |          ..|.. ||...|  ||  |..|||    .  . .||||...
lkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvfliti..dgdpssdyinaali
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1455-1520 7.6e-07 23.4 In-house 1-66 (69) alignment 
Range on Protein: 1455-1520
Range on HMM: 1-66/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISMYLKL
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   ..|  |.. .   |||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 92-159 9.7e-07 23.2 In-house 20-85 (325) alignment 
Range on Protein: 92-159
Range on HMM: 20-85/325.0
CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPnlDMCQREYINANYVH
   .||  ... | . . ..  .    .||| |||||.  .| .|. | |    |  . .||||.|..
qdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkk..ddpssdyinasylr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1409-1517 1.7e-06 21.6 In-house 214-343 (349) alignment 
Range on Protein: 1409-1517
Range on HMM: 214-343/349.0
GSSSWDVMQFQVTNWPTDGIIREPRTVLQV-------IDEVIHR--QQKIGGGPVVVHCSDTVSRSGVYCSVSIALE--QCKAEGVV----------DVF
 .. . ..|.|| ||.  ... .| ..||        ||.   |   ..    ...||||    |.||.. . . |.  .   .  .           ..
vekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

QVTKSVRRSKPGAVTTLDQYSSIYEVISMY
 .  ..|. .   |  | |.  ||| .  |
iivnelrkqrismvqnlaqfiaiyealLky
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 81-161 1.8e-06 22.1 In-house 7-88 (315) alignment 
Range on Protein: 81-161
Range on HMM: 7-88/315.0
SMEELGNHVAT---CHSNGFEEQYKSLYTGEDKSCSIGYSEDNKAFNRFKNITVYDDNRITL-ITNPNldmCQREYINANYVHEC
 ...|  .||       |||...|.|.  |. .   .     ||  ||. ||  ||  |. | ... .    . .|.|||..   
pldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllend...phsdyvnanfidGy
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 248-304 2.3e-06 21.9 In-house 2-57 (69) alignment 
Range on Protein: 248-304
Range on HMM: 2-57/69.0
VVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTlEIHYYQA
|||||    |.| . .. . . . |.| .||.|   . .|. .|  |   || |   
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmn.eieyifi
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1419-1516 2.6e-06 21.2 In-house 196-288 (310) alignment 
Range on Protein: 1419-1516
Range on HMM: 196-288/310.0
QVTNWPTDGIIREP-RTVLQVIdeviHRQqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLDQYSSIYEVISM
.  |||  |.  |   || | .      |  .  ||.|||||  . | .| ... ..... .    ||. .|   ...|.   . |  ||  |  |  .
kwpnwpdrgvpdekchtvpqrl....laq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 209-301 3.1e-06 21.4 In-house 174-261 (288) alignment 
Range on Protein: 209-301
Range on HMM: 174-261/288.0
LQFQVTNWPTDGVIREPRTVLQVIDEViHRQQKigggPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTTLEIHY
 .  . .|. |||  .  . |.... . .  ||    |.|||.|  | |.|    . ||||. . .  . . .. .. | ..  |..|   . 
kilhlleWdddgvPenylsplrllevl.kslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqyl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 212-296 6.2e-06 20.0 In-house 196-275 (310) alignment 
Range on Protein: 212-296
Range on HMM: 196-275/310.0
QVTNWPTDGVIREP-RTVLQVIdevIhRQqkIGGGPVVVHCSDTVSRSGVYCSVSIALEQCKAEGVVDVFQVTKSVRRSKPGAVTT
.  |||  ||  |   || | .   .  |  .  ||.|||||  . | .| ... ..... .    ||. .|   ...|.   . |
kwpnwpdrgvpdekchtvpqrl...l.aq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqt
subfamily_PTPN12_pd Subfamily PTPN12 110-159 6.7e-06 20.2 In-house 30-77 (290) alignment 
Range on Protein: 110-159
Range on HMM: 30-77/290.0
KSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLDmcQREYINANYVH
 | . | .| |.. ||.|.|  || .|..| .. . .  . .|||||...
ysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfik
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 108-164 9.6e-06 19.8 In-house 21-69 (267) alignment 
Range on Protein: 108-164
Range on HMM: 21-69/267.0
EDKSCSIGYSEDNKAFNRFKNITVYDDNRITLITNPNLdmcqreYINANYVHecCYQ
.   .|  ..|.|...||. .   |||.|. | |. .       |||| ||.  .|.
tsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyve..gyk