Gene PTPRD-74 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP133_AA protein Get Run
AqueP133_AA_993-1273 phosphatase_domain Get Run
AqueP133_AA_1285-1574 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 989-1336 1.7e-126 418.2 In-house 3-346 (564) alignment 
Range on Protein: 989-1336
Range on HMM: 3-346/564.0
EPIPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSN
.||||||...|.|||....|| || |||.... .| . ..|. |.| .|||..|.  ||.||| |.... . |||||||||||||...|||||.||||..
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRAlNeTMDVGyDLQVTLVEQQQYVDYKLKKFLIlNTSSTGGRLDVTHYHFLAWPDHGVPADKTI
|. |||||||| .  ||||||.| |.| .|| .|||   . |  .| .|.|||.|.... || ...| . .....     |...|| .|||||||   | 
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetyg.eltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesats

MLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKqEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLKIVM
.|..||.||....|.  |..||||||||||||||..|.| .|. . ||...||......|. |  ||||| ||..||.|. |...||.|......||  .
lLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhl

DELTKVSEK--KSGYEKQLELINQVCRQPTEGLlCDALSKTNIGKNRFPS
..|..|.|.   .|.|.  . ..   ....|     |  . | .||||. 
qkLaeveedtemtgleleFqrLatakeieleef.avatkpknkkknrfsn
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 991-1299 4.1e-98 323.3 In-house 2-307 (318) alignment 
Range on Protein: 991-1299
Range on HMM: 2-307/318.0
IPVAEFAAHTAKLHSDRDLGFEDEYKSF-RNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNT
|.| ... | ..|... .| .. ||. . |.  . . . .  | |  |||. |. .||..||.|. . .. |||||||..||||.| |||||||.||..|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMDvgyDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRlDVTHYHFLAWPDHGVPADKTIM
. |||||||| .  .|||||.. ||| .|.  |||    ....   .|.|.| |. .. || |..| . .| .   | .|  ||. .|||.|||.. . .
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsyg...klvvelkeevelsdyvlrefkvtrteeeesr.qvrqyhytsWpdegvpesgasl

LAFIRRVRQTH-PPEGPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLKIVM
|...|.|.... ...  |..|||||||||||.||..|.. .|. |.|. ......  ..|. | |||||| ||..|.|.| |....||| . .. |.  .
ldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdilleri.kaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsri

DELTKVSEKKS
 ||.... .  
relreqdpesg
subfamily_PTPRB_pd Subfamily PTPRB 989-1273 4.8e-98 322.8 In-house 5-286 (293) alignment 
Range on Protein: 989-1273
Range on HMM: 5-286/293.0
EPIPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIP-QGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLS
.|| . .|..| .|...| ||.| .||......  . . ..|.|..| .|||..|. .|| |||.|.|. |..|||||||..|.||. |. .||.|||| 
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlp

NTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETmDVGyDLQVTLVEQQQYVDYKLKKFLILNtssTGGRLDVTHYHFLAWPDHGVPADKT
.|| |||||||| .  .|||||.|.|.|  ||  |||.  ...   | |..||||..... |. .....| .   .  . .|..|||..||||||| . .
etvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyG.dikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektk

IMLAFIRRVRQTH--PPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKqEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT
 .|.|.|.||...    .  |..||||||||||||||.|| . |.... |  ..|. ..|..|. |.|.||||.||..||... ....
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPRG_pd Subfamily PTPRG 991-1285 3e-95 314.5 In-house 1-300 (563) alignment 
Range on Protein: 991-1285
Range on HMM: 1-300/563.0
IPVAEFAAHTAKLHSDRDLGFEDEYK--SFRNIPQ-GSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGS-DYINASFIDGYKRPKAYIAAQGPL
.|| ||| | |.||.| | ||. |..    . |..   ..... |||  |||  |. .||.|||.|. .|.| .. |||||..||||.. ||.||.||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

SNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRalNETMDVGyDLQVTLVEQQQYVDYKLKKFLILNTS-----STGGRLDVTHYHFLAWPDHG
 .|. |||||.|| .  .|||.|.| |||  ||  |||.  .|....|  |||||.|... . |  ... | |.      ..   . |..||.  |||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetyg.alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg

VPADKTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDkQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTT
||  ..  | |...  .... |  |..||||||||||||.| ||.. ...  ||.  |...||  .|..|  .|||| ||...|||| | |. ..| ...
vPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiq.qenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketella

KRLK
....
eqve
0051299 (Phosphotyrosine protein) phosphatases II 990-1272 1.9e-94 311.6 In-house 4-286 (288) alignment 
Range on Protein: 990-1272
Range on HMM: 4-286/288.0
PIPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIP-QGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSN
.|.| |.. .  ||. .   |...|.. ....  ......|.||||..|||. ... ||.||| |. ...  ||||||||.||||......||.||||.|
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRalNETMDVGYdLQVTLVEQQQYVDYKLKKFLILNTS---STGGRLDVTHYHFLAWPDHGVPAD
||.|||||||| . ..|||||.|.|.|  ||  |||   .... .|  ..|||.. ... ||.. .. . |..    .|  . |||.|...||||||| .
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd.itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

KTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQeKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
 . .|.|.|.||. ... |.| .||||||||||||||.|| . ..|.|. . ....|... .|..|  ||||. ||.....|| ||.
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 999-1294 2.5e-93 308.1 In-house 8-298 (317) alignment 
Range on Protein: 999-1294
Range on HMM: 8-298/317.0
HTAKLHSDRDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVW
.  .|.     ....|.. .....  .|..|.|||| .|||. ... ||.||| |. ..   .|||||||..||.......||.||||.|||.|||||||
alldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvw

EFQLPTIVMLTELIERGIDKCTCYWPRalNETMDVGYdLQVTLVEQQQYVDYKLKKFLILNTsSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQ
| .. .||||||| |.|  ||  |||   .||. .|  ..|||.. ... ...| .. . ..  ..  . |||.|...||||||| . ...|.|...||.
eqgvtvivmLteleelgrekcaqYwpl..getltygd.ftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavre

THPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQEkDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLKIVMDELTKV
  ...| |..||||||||||||||... | ..|.| . .....| .. .| .|  .|||..||....||| ||.....|.   ..||  ...|. .
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllip
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 990-1293 2.8e-93 307.5 In-house 4-304 (319) alignment 
Range on Protein: 990-1293
Range on HMM: 4-304/319.0
PIPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNT
.|.|.|.. .. .|.|  . ..| |.| ...  . ....|. .|| .|||..|. .|| .|| |...... |||||||||||||.. ...||.|.||.||
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

VGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRAlneTMDVGYDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIM
. |||||||| .  ..||||.| |..  |.  |||..   .. ..  | ||| |...  ||  .|. . . ||     .|.|.....||||.|| . | .
iedfWrmvWeeessivvmltklveklkvklkkywpee...nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsl

LAFIRRVRQTHPP-EGPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLKIVM
|....|.|...   .  |..||||||||||||||.|| | .|. |.|  |.....  ..|| | .|||...|| .|..|| |....||| .  . |.  .
ldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlerv.keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl

DELTK
 .|..
kqlae
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 990-1293 6.1e-93 306.3 In-house 3-304 (305) alignment 
Range on Protein: 990-1293
Range on HMM: 3-304/305.0
PIPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIpQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNT
.| ....||.  . ... | |.| .|||. .  . |.   |  .|..|||....  .| .|. ||. ...  |||||||..||||| |.||.||||| ||
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

VGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMDVgYDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIM
| ||||...|..  ||||||.|.| | |||  ||| . .|...   ...|.| ..... ||  .|. | . ..      |..|..  |||||||   | .
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

LAFIRRVRQTHPPE-GPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLKIVM
| .|.||....  . | ||.|||||||||||.||..| . .|| |.|. ....| | ..|. |. |||| .|||..|||| |.|||||||.  . |.. .
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerl.kkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

DELTK
. | |
nklkk
0050432 (Phosphotyrosine protein) phosphatases II 988-1273 3.3e-92 304.4 In-house 23-300 (308) alignment 
Range on Protein: 988-1273
Range on HMM: 23-300/308.0
WEPIPVAEFAAHTAKlhSDRDLGFEDEYKS-FRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELtaipdKRGSDYINASFIDGY--KRPKAYIAAQG
.....| ... .  |   .   ..| |..  ... | ..|..|.||||..|||. ... ||.||| |     . ||||||||..|||  |.|...||.||
slklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqg

PLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALN-ETMDVGyDLQVTLVEQQQYVDYKLKKFLILNTSSTgGRLDVTHYHFLAWPDHGVP
||.|||.|||||||| . ..|||||.|.|.|. ||  |||  |. ... .| ...|||...... ||.. .. . |...    . |||.|...|||||||
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg.kftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvP

ADKTIMLAFIRRVRQTHppEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQeKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT
 . .|.|.|...||...  .|.| .||||||||||||||.|| . ..|.|. . ....| .. .|..|  ||||. ||.....|| ||. 
pspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0046845 (Phosphotyrosine protein) phosphatases II 1011-1276 2e-90 298.3 In-house 2-278 (284) alignment 
Range on Protein: 1011-1276
Range on HMM: 2-278/284.0
FEDEYKSFRNIPQG---SYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDK-RGSDYINASFIDGY-----KRPKAYIAAQGPLSNTVGDFWRMVWEFQ
.|.|..  ...      |...|.||||.||||. ... ||.||| |. ....  .|||||||..|||     ...|..||.||||.|||.|||||||| .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

LPTIVMLTELIERGIDKCTCYWPRAlNETMDVGYdLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHP
 ..|||||||.|.|  ||  |||   .|..  |  ..|||.. ... ||.. .. . |.. ||  . |||.|...|||||||.. ...|.|.| ||. ..
vrvIVmltelvengrekcaqYwple.gevltygd.ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

--PEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQEK--DLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGD
  | |.| .||||||||||||||.|| . ..|.|..    ....| .. .|..|  ||||..||.....|| ||. .. 
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0036941 (Phosphotyrosine protein) phosphatases II 1017-1282 1.4e-88 292.3 In-house 22-287 (297) alignment 
Range on Protein: 1017-1282
Range on HMM: 22-287/297.0
SFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELtaipDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGI
 ......||...|.||||..|||. ... ||..|| |    |. ||||||||..|||......||.||||.|||.|||||||| . ..|||||||.|.| 
llpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgr

DKCTCYWPRALNETMDVGyDLQVTLVEQQQ--YVDYKLKKFLILNTsSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHP--PEGPPLIVHCS
 ||  |||   .|.. .| |..|||.. ..  . ||.| .. ...|  .|  . |||.|.. ||||||| . ...|.||..||. ..  |.|.| .||||
ekcaqywpleegesltyg.dftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCs

AGVGRTGTFITLDSMQQRLDK--QEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTK
|||||.||||..| | |.|..   |. ..|.|..  .|..|  .|||. ||.....|| |.. ...| .   
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll
0043336 (Phosphotyrosine protein) phosphatases II 990-1272 4.6e-88 290.6 In-house 1-277 (278) alignment 
Range on Protein: 990-1272
Range on HMM: 1-277/278.0
PIPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNT
||.| ... . ..|. .   ... |........ ..|..|.||||..|||. ... ||.||| |. ..   .|||||||..|||..|...||.||||..|
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

VGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPralNETMDVGYdLQVTLVEQQQYVDYKLKKFLILNtSSTGGRLDVTHYHFLAWPDHGVPADKTIM
|.|||||||| . .|||||||| |.|  ||  |||   .... .|  ..|||...... ||.. .. . |   .|  . |||||.|.||||||| . ...
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygd.ftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsll

LAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQEkDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
| |...||.  .... |..||||||||||||||.|. . ..|.|    ....| .. .|..|  .|||. ||.....|| ||.
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 988-1273 5.1e-88 291.0 In-house 6-305 (307) alignment 
Range on Protein: 988-1273
Range on HMM: 6-305/307.0
WEPIPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIPQ---GSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDK-RGSDYINASFI--------DGYKR
...|..  .  . ..|. |   |.. |.......     |.|..|.|||| .|||. ... ||..|| |. ....  .|||||||..        |||..
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

PKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRAlNETMDVGYdLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFL
....||.||||..|| |||||.|| .  .|||||||.|.|  ||  |||   .|..  |  ..|||.. ... .|.. .. . ... ||  . |||.|..
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn.ftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

AWPDHGVPADKTIMLAFIRRVRQTHP--PEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQEKD--LNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEY
.||||||| .  ..|.||..||. .   |.| | .||||||||||||||... | ..|.|...   ....| .. .| .|  .||.. ||.....|| |.
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

IT
. 
ll
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 998-1271 5.4e-88 289.8 In-house 10-278 (288) alignment 
Range on Protein: 998-1271
Range on HMM: 10-278/288.0
AHTAKLHSDRDLGFEDEYKSFRNIPQ-GSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRM
|..|| . .   ||..||.|  .. .  | |...|..| .|||..|. .||  ||.|.  ....|.||||||.|||.|. |.|||.|||| .||.|||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEFQLPTIVMLTELIERGIDKCTCYWPRALNETmDVGyDLQVTLVEQQQYVDYKLKKFLILntsSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRV
|.| .  ||||||||.|.|  ||  ||| | ...   | ...|||||...  |. |.|.|.     ....|..|.|..|||||||||..|. .|...| |
vyenktstivmltelveggktkCeeYWPdadkpk.nyG.svtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqv

RQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKqEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEY
 .... .  |.|||||||||||||||.|| . ..... |. ... ...|..|  | |.|||. ||..|...| . 
kvanqadtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_PTPRD_pd Subfamily PTPRD 1325-1578 8.8e-87 287.0 In-house 45-286 (564) alignment 
Range on Protein: 1325-1578
Range on HMM: 45-286/564.0
SKTNIGKNRFPsklDTLPYDMTRVRLRTASG--TGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKv
 ..|  |||.    . ..|| .||.|..  |    |||||...|||..| |..|||.|..||.|| ||||||| ||.|||| .|||..|. |.||||.| 
kpaNkaKNRya...nivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.

DeSVTYGKMVVKLVSEEKRPHYIIRKLMLSQEStyinvsagAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQmNTGNKAITVMCSDGIGRTGS
. . |||...|.|..||.  .|.||.. |....          .  .|.|||...| .   |.  |.||.||..  . . ..... |.| || |.|||| 
g.tetygeltVtleeeeeladyeirtfklkkkk........ssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGt

FMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSFDA
|. . ..||||| | . |..||.|  | .|. .||.  || |.|..|||...... 
fividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
0039614 (Phosphotyrosine protein) phosphatases II 989-1276 3.5e-86 284.6 In-house 12-293 (297) alignment 
Range on Protein: 989-1276
Range on HMM: 12-293/297.0
EPIPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIPQGsYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDK-RGSDYINASFIDGYKR-PKAYIAAQGPL
.|||.  ....  ... .   ... |...  ...   |..|.||||..|||. ... ||.||| |. ...   .|||||||..|||.. ....||.||||
ipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

SNTVGDFWRMVWEFQLPTIVMLTELIERGIdKCTCYWPRALNetmdVGYDLQVTLVEQQQYVDYKLKKFLILNtssTGGRLDVTHYHFLAWPDHGVPADK
..||.|||||||| . ..|||||.|.|.|  ||  |||   .    .  |..|||.. ... .|.. .. . |   .|  . |||.... ||||||| . 
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppsl

TIMLAFIRRVRQTHP--PEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQeKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGD
...| |.. ||. .   |.| | .||||||||||||||... | ..|.|  ......| .. .| .|  .|||. ||....||| |.. ...
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0047943 (Phosphotyrosine protein) phosphatases II 1016-1272 2.2e-85 281.7 In-house 19-272 (273) alignment 
Range on Protein: 1016-1272
Range on HMM: 19-272/273.0
KSF-RNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELtaipDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIER
. . ...|...|..|.|||| .|||. ... ||.||| |    .  ||||||||..|||......||.||||.|||.|||||||| . ..|||||||.|.
elllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvel

GIDKCTCYWPRALNE-TMDVGYdLQVTLVEQQQYVDYKLKKFLILNTSSTGgRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPP--EGPPLIVHC
|  ||  |||   .| .. .|  ..|||...... ||.. .. . |...    . |||.|.. |||||||.. ...| ||. ||...    ...| .|||
grekcaqYwpleggelsltygk.ftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHC

SAGVGRTGTFITLDSMQQRLDKQeKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
|||||||||||.|| . ..| |  . ....| .. .|..|  ||||. ||.....|| ||.
saGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 985-1292 5.6e-85 280.1 In-house 8-315 (330) alignment 
Range on Protein: 985-1292
Range on HMM: 8-315/330.0
KERWEPIPVAEFAAHTAKLHSDRDLGFEDEYKSFRN-IPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQ
.... |.|| ..     .  .|    | .|....     |... .|.  ||  |||. |.  || ||| |. .  .  |||||||||||||. . .||||
nkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaq

GPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMdvGyDLQVTLVEQQQYVDYKLKKFLILNTSSTG---GRLDVTHYHFLAWPDH
||...|| |||||.||..  |||||||| ||  .||. |||     |   | ...|.. ...  ||| ..|||. . . .        |. .|| .||| 
GPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvty..G.nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv

GVPADKTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMT
|||..   || ....|..... .. |..||||||||||||||.||.. .|. | |. ....||. ..|. |  ||||. ||..|. .| ||   ||| . 
GvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlerv.kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteld

TKRLKIVMDELT
   |.  ...| 
vsslekhlqkly
subfamily_PTPRK_pd Subfamily PTPRK 992-1296 8.6e-84 276.0 In-house 5-301 (314) alignment 
Range on Protein: 992-1296
Range on HMM: 5-301/314.0
PVAEFAAHTAKLHSDRDLGFEDEYKSFRNIpqgsYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVG
 ||.   . |.|.     || .||.|. .     . .||  || .|||.... .|| ||| |..| .   ||||||..||.||||.|.|..|||| .|| 
rvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPralNETMDvGYDLQVTLVEQQQYVDYKLKKFLILN-TSSTGGRLDVTHYHFLAWPDHGVPADKTIML
||||.|.. .  .|||||||.| |  ||. |||   ..|.    |..|.||| .   ..  . | . . . .  ..  | ...||.||||.||  .| .|
dfWrlvydencasivmltelvevgrvkClkyWP...edtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgll

AFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLKIVMDE
...||| .....|  ...|||||| |||||||..|.. . . ..|. .....   ..|. .| ||.|| ||..|.|.. |   ||.|.. . ..| .  |
klvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmi.eregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

LTKVSE
 ...  
sirldp
DSPc_SM00195 1013-1272 1e-83 276.1 In-house 4-262 (263) alignment 
Range on Protein: 1013-1272
Range on HMM: 4-262/263.0
DEYKSFRNI-PQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTEL
 |... ..  .. . |.|. ..|.||||..|.. ||..||.|. ...| |||||||..|.|....|.|||.||||..|| |||||||| . ..|||||| 
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

IERGIDKCTCYWPRALNETMDVGyDLQVTLVEQQQYV-DYKLKKFLILNTSStGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGPPLIVH
 |.|  ||. |||.  ......| ...|.|||....  ...|... . ..       .||.|.. .||||||| ... .|...| |....  . .|..||
eengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGTFITLDSMQQRLDKQEKdLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
|||||||||||.|.|.. ..|....| ..| | . ..|. |  ||||..|| .|..|. |||
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1013-1272 1e-83 276.1 In-house 4-262 (263) alignment 
Range on Protein: 1013-1272
Range on HMM: 4-262/263.0
DEYKSFRNI-PQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTEL
 |... ..  .. . |.|. ..|.||||..|.. ||..||.|. ...| |||||||..|.|....|.|||.||||..|| |||||||| . ..|||||| 
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

IERGIDKCTCYWPRALNETMDVGyDLQVTLVEQQQYV-DYKLKKFLILNTSStGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGPPLIVH
 |.|  ||. |||.  ......| ...|.|||....  ...|... . ..       .||.|.. .||||||| ... .|...| |....  . .|..||
eengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRTGTFITLDSMQQRLDKQEKdLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
|||||||||||.|.|.. ..|....| ..| | . ..|. |  ||||..|| .|..|. |||
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0050432 (Phosphotyrosine protein) phosphatases II 1267-1579 1.3e-83 276.2 In-house 7-305 (308) alignment 
Range on Protein: 1267-1579
Range on HMM: 7-305/308.0
ALSEYITCGDTSMTTKRLKIVMDELTKVSEKKSGYEKQLELINQVCRQPTEGLLCDALSKTNIGKNRFPSkldTLPYDMTRVRLrtaSGTGDYINANHVD
|| |.....|||.... ||. ...| |  ||. .. .  |  ........ .    || . |. |||...    |||| .||.|   ... |||||..||
allelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykd...ilpydhsRVkl...degsdYInAsyvd

GY--KHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVD-ESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEStyinvsag
||  |.. .|.|||.|...|||| ||||||| .. ||||..|.||..| ||.|||.... .|..|||..|.|.|||....|..|.|.|.  .        
gyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg........

AADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQmntGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYE
  . ..||.||| || ..  | . ..||...... . .   ... | |.||.|.|||| | ... .||... |   |||...|  |  ||| ||.. ||.
dgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqyl

FCHDIILEYINSFDAY
|.....|||....  .
flyralleylklkltk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 999-1278 8.1e-83 273.1 In-house 17-296 (298) alignment 
Range on Protein: 999-1278
Range on HMM: 17-296/298.0
HTAKLHSDRDLGFEDEYKSFRNIPQ----GSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFW
 .|. .. .  |...|.. .... .     ... |. ||| .|||. .. ..||||| |... ..  ||||||||...||. .|.||.|.|| .|| |||
laavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFW

RMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMDvgyDLQVTLVEQQQYVDYKLKKFLILNTSSTgGRLDVTHYHFLAWPDHGVPADKTIMLAFIR
|||.| .  ||||||.| | .  |.. |||   .|| .   ...|.| ..... |.  .|. . ..... ..  | . ||  |||.|||. .| .|...|
rmvteedigtiVmltnleeldktkyhkywPdegketyg...eitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllr

RVRQTHPPEG-PPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTS
.||...   |  |.||.|||||||.|||| .||. .|. |.|. . ... .  .|. |. .||||.|||.|..|  |....... 
kvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlerv.kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 998-1273 1.2e-82 272.2 In-house 4-277 (281) alignment 
Range on Protein: 998-1273
Range on HMM: 4-277/281.0
AHTAKLHSDRDLGFEDEYKSFRNIPQGSYTTA-KLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRM
.|...|... . ||  ||.....| ... .|| | .||| |||. |. .|| .||..|   ..  .|||||.|..||| .|.|||.|||. ... .||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWEFQLPTIVMLTELIERGIDKCTCYWPrALNETMDVGyDLQVTLVEQQQYVDYKLKKFLIlnTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRV
||| .  .|||.|. || |  ||  |||   |... .| |..|. .....   |  .|| .  . ..|   .|.. ...|||||||||. . .| | . |
vweqkvsaivmvtreieagklkChrYWP.ddnselkyg.dvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkev

RQTHPPEG-PPLIVHCSAGVGRTGTFITLDSMQQRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT
.... ..   ||..|||||||||||.|.|| . .........|.. . .|..|  | ||||| .|| ... |. ... 
lkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN9_pd Subfamily PTPN9 1004-1272 3.5e-82 270.8 In-house 11-290 (297) alignment 
Range on Protein: 1004-1272
Range on HMM: 11-290/297.0
HSDRDLGFEDEYKSFRNI-PQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQL
.. .  |   ||.  ||  ..| ....||. |..|||...|  ||..|| |. ....  ||||||.|.||||..||.||.|||| .|| |||||||| . 
kekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqev

PTIVMLTELIERGIDKCTCYWPRALNETMDVGyDLQVTLVEQQQYVDYKLKKFLILNTSsTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQT---
 .||| | ..|||  ||. |||   ..... | ||.|. ||.... ||| ... | |.  |.    |||. ||.|||.||| . . .| ... ||..   
lvivmttrvvergrlkcgqyWpleeessaefg.dlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

----------HPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQeKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
           .|.|||..||||||.||||||||||   .||...   ... | .  .|| |  ..||. ||.. . |. || 
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleev.gtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1277-1579 3.4e-81 267.8 In-house 3-296 (298) alignment 
Range on Protein: 1277-1579
Range on HMM: 3-296/298.0
TSMTTKRLKIVMDELTKVSE--KKSGYEKQLELINQVCRQPTEGLLCDALSKTNIGKNRFPsklDTLPYDMTRVRLRT--ASGTGDYINANHVDGYKHRG
| .... ||. . .|..|..  | .||... . .|.|  .  |     | ...|  |||..   | ...| .||.|..  |   .||||| ....||.| 
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRya...diialdssRvvLekedadeesdYiNAsflhaykgrn

AFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDEsvTYGKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsagaADHLMVTQ
||.|||||..||||| ||||.|. ...|||| |||| .|  . |||||.  |  |||.. |.| |.|.   .|.|||..|....        ... .| |
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkke........ekerevrq

FHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEY
.|...|..   |. .| .|.|...   .| ..|||...| ||.|.||.|.|. ..|||||.|.|.| ||||..|  | .|||.||   || |.....||.
lhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea

INSFDAY
..||. .
ldsfnde
subfamily_Ptp69D_pd Subfamily Ptp69D 991-1291 3.1e-80 264.6 In-house 4-305 (307) alignment 
Range on Protein: 991-1291
Range on HMM: 4-305/307.0
IPVAEFAAHTAKLHSDRDLGFEDEYKSFR-NIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNT
|.. . .    . . | | |.. ||..   .  . | ....  ||  |||.|.. ..|. || |. |. |  ||||||||| |||  | .||||.|. .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

VGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRAlnETMDVGyDLQVTLVEQQQYVDYKLKKFLILNTSSTG----GRLDVTHYHFLAWPDHGVPAD
.||||||..| .. .||||..| |   .||  |||    ...  | |. |.||....  ||  ... . ..  ..     .  |. ||...|.|  ||  
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

KTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLK
 . .| .|..||. .  .  |..|||||||||.|.|..|||. |.| |.|. ..|.|.  ..|  | |.||  .|||... || .|.. ||| .. . |.
argllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqql.kaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddle

IVMDEL
  ...|
daierl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 989-1281 4.8e-79 260.5 In-house 4-288 (315) alignment 
Range on Protein: 989-1281
Range on HMM: 4-288/315.0
EPIPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSN
.|||. .. .. |. ..    ||...|.|          .||  ||. |||. |. .|| |||.|  .  . .|||.||.|||||.... |||||||. .
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnva

TVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRAlneTMDVGyDLQVTLVEQQQYVDYKLKKFlilNTSSTGGRLDVTHYHFLAWPDHGVPADKTI
.|.||||.|.| .. .|||||.|.|.   |.  |||      .  |  . ||....... .|  . .    . .     .|  .|. .||| |||.  . 
svkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyG.kitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytip

MLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDkQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTT
.. .||.|.| |  .  ...|||||||||||||||||.. ....  |. ...|.|. ..| .|. |||. .|| .|.||| | . |||||.. 
lmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqae.aenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaq
0045098 (Phosphotyrosine protein) phosphatases II 1011-1276 5.4e-79 260.7 In-house 11-276 (278) alignment 
Range on Protein: 1011-1276
Range on HMM: 11-276/278.0
FEDEYKSFRNIPqGSYTTAKLPENVSKNRFENVYSYDSSRVEltaipdkrgsDYINASFIDGYkrPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTE
 | |..   .|| ...|.| ...|..|||. ... ||.|||           ||||||.||||  ||..||.|||| .|| |||||.|| . ..||||||
lefefllllgip.seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

LIERGIDKCTCYWPRalNETMDVGYdLQVTLVEQQQYVDYKLKKFLILNT---SSTGGRLDVTHYHFLAWPDHGVPADK--TIMLAFIRRVRQTHP----
|.|.|  ||  |||   ....  |  ..|||.. ... || | ..|. |.    ...  . |||.|.| ||||||| .   . .| .....|. .     
lvelgrekcaqywpe..ggsltygd.ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

---------PEGPPLIVHCSAGVGRTGTFITLDSMQQRLdkqEKDLNIYEFLANMRTMRVL-MVQTEAQYVYIHDALSEYITCGD
         ..| | .||||||||||||.. .. | ..|   |. ....| .. .|..|   .||.. ||......| |.. .|.
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
0040439 (Phosphotyrosine protein) phosphatases II 1025-1273 1.1e-78 259.6 In-house 2-247 (249) alignment 
Range on Protein: 1025-1273
Range on HMM: 2-247/249.0
SYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWP
.|..|.||||..|||. ... ||.||| |. .|.  .|||||||.||||......||.||||..||.|||||.|| .  .|||||.| |.|  ||  |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

RalNETMDVGYdLQVTLVEQQQYVDYKLKKFLILNTsSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHP--PEGPPLIVHCSAGVGRTGTFI
   .... .|  ..|||.. ... ||.. .. . |.  .|  . |.|.... ||||||| .  ..|.||..||. .   |.| |..||||||||||||||
l..ggsleygd.ftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

TLDSMQQRLDKQeKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT
... | ..|.|  ......| .. .|..|  .||.. ||.....|| |.. 
aaylmleqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1310-1580 1.2e-77 256.1 In-house 28-287 (318) alignment 
Range on Protein: 1310-1580
Range on HMM: 28-287/318.0
QVCRQPTEGLLCDALSKTNIGKNRFpskLDTLPYDMTRVRLRTASG--TGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLE
.. |.. .    ..|...|  |||.    . |.|| |||.|.. .|  . ||||||..|||... |..|.|||. ||.||.||||||| |. |||| ..|
rlsrseetvtslkslepvnkaknry...anilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqee

ENEKEVCAKYWPDKvdESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEstyinvsaGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTGNK
|. |. ...|||.|  .| .|||.||.| .| .  .|..|.. ....        .  .. .| |.|| .|..   |.. . ||.|. |  . |...|..
ergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrt........eeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgag

AITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSFDAYH
.|.| || |.|||| |. . ..||||| |.. ||||..|  | .|. .||   ||||..|..||...|.|.. 
pivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1311-1577 1.4e-77 255.9 In-house 31-287 (319) alignment 
Range on Protein: 1311-1577
Range on HMM: 31-287/319.0
VCRQPTEGLLCDALSKTNIGKNRFPsklDTLPYDMTRVRLRTASGT--GDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEE
  .....  .  |  . |  |||..   . |.|| ||| | .  |.   |||||...|||..| .|.|||||...|.||.||||||. || .|||..| |
llkeavndtfdsaskeenkkknryq...nilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklve

NEKEVCAKYWPDKvdESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTYINVsagaadhLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTGNKA
. |  . ||||..  . ..||...|.| .||.  .||||||.| . |. ..         .|..|.| .|.... |.. | ||.|. .. . . .| .. 
klkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevet.......RevkhfqyteWpdhdvPekatslldllkrirksrektqsgP

ITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSFD
|.| ||.|.||||.|. .  .|||.| |.| |||....  |  |. .||.  ||.|.....||.....|
ivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0042113 (Phosphotyrosine protein) phosphatases II 1026-1272 5e-77 253.9 In-house 1-243 (245) alignment 
Range on Protein: 1026-1272
Range on HMM: 1-243/245.0
YTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPR
|..|.||||..|||..... ||..|| |. ..   .|||||||..|||.... .||.||||..||.|||||.|| .. |||||||. |.|  ||  ||| 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

alNETMDVGYdLQVTLVEQQQYVDYKLKKFLILNTsSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHP-PEGPPLIVHCSAGVGRTGTFITL
  .|.. .|  ..|||.. ... ||.. .. . |.  ..  . |.|||.| ||||||| .  ..| |...||.    ... |..||||||||||||||..
..gesltygd.ftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

DSMQQRLDKQeKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
. | ..|.|  ......| .. .| .|  .|||. ||.....|| |..
ylmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyeallell
0036941 (Phosphotyrosine protein) phosphatases II 1293-1577 1.7e-76 252.7 In-house 4-281 (297) alignment 
Range on Protein: 1293-1577
Range on HMM: 4-281/297.0
KVSEKKSGYEKQLELINQVCRQPTEGLLCDALSKTNIGKNRFPSkldTLPYDMTRVRLrtASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMV
| .||.... . |.   ....    | |  ||.. |. |||...    |||| |||.|   ..  |||||..||||..  .|.|||.|...|||| ||||
kllekllflalllkefeellpllllgslsvallpenleknRykd...ilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmv

WEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVSEEK--RPHYIIRKLMLSQEstyinvsaGAADHLMVTQFHYVNWAEDEKPKDETPL
||| ...||||..|.|...| ||.|||....||.|||...|.|.|.|.   ..|..|.| ..          |  ....||.||| .| ..  | . ..|
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt........gngesrtvthfhytgwpdhgvpespasl

LKLIDQLLHNQMNT-GNKAITVMCSDGIGRTGSFMCMYSVLERIK---IESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSFD
|..|..... . .. ... . |.||.|.||.|.| ... .|....   .|   |.....|  |  ||| ||.. ||.|.....||......
ldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0051299 (Phosphotyrosine protein) phosphatases II 1318-1573 1.9e-76 252.6 In-house 39-286 (288) alignment 
Range on Protein: 1318-1573
Range on HMM: 39-286/288.0
GLLCDALSKTNIGKNRFpskLDTLPYDMTRVRLRTASG--TGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCA
. |  || . |. |||.    | |||| .||.|.. .|  ..|||||...|||..  .|.|||.|...|||| ||||||| .. ||||..|.|...| ||
ltlsaallpenleknRy...sdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekca

KYWPDkvDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTYInvsaGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMnTGNKAITVMCSD
.|||.  ..|.|||...|.|.|||. ..|..|.|...  ...     |   ...||.||| || ..  | . ..||... .. . .   |.. . |.||.
qYwpl..ggsltygditvtllseevlddytvrtlevtnldlld....gdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsa

GIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
|.|||| | ... .||... | . ||....|  |  |||.||.. ||.|.....|||.
GvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1299-1577 4e-76 251.1 In-house 22-287 (305) alignment 
Range on Protein: 1299-1577
Range on HMM: 22-287/305.0
SGYEKQLELINQVcrqpTEGLLCDaLSKTNIGKNRFPSkldTLPYDMTRVRLRTASGTG--DYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQW
.|.|.| ... .      | .  .  ...|  |||. .   . ..|. |..|.. . ..  |||||..|||||.. .....|.|.|.||.| ||...|  
kgleaqykslyee....eesidvg.kkeankaknrlke...itlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveek

SSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsagAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQ
 |.||||..| |..|. | .|||... |.. .|...|.| ||.. . ||.||| .|.|..         .   |.|..  .| ..  |.  | ||.||..
vstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.......dkesrtvlqyqltdWPdhGvpqfatsllslikr

LLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSFD
. ..|..  .....| ||.|.|||| |...   |||.| | | |||...| .| .|...||.  || |.||.. |.|...|
vqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
Y_phosphatase Protein-tyrosine phosphatase 1034-1269 4.5e-76 250.7 Pfam-A 1-234 (235) alignment 
Range on Protein: 1034-1269
Range on HMM: 1-234/235.0
NVSKNRFENVYSYDSSRVELtaiP-DKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMD
| .|||....  ||..||.|     ..  ||||||....|||..|..||.||||..|..|||||||. .  .|||||.| |.|  ||  |||.. .|.. 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

VGyDLQVTLV-EQQ-QYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQR
 | |..|.|. ... .  .| |.|. . .. .   .  |...|. .|||||||.... .| .||.|.... ..  |..|||||||||||||..|| . ..
yg.dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LDKQEKdLNIYEFLANMRTMRVLMVQTEAQYVYIHDALS
|...|. ....... ..|. |  |||...||.....|. 
leaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1034-1269 4.5e-76 250.7 In-house 1-234 (235) alignment 
Range on Protein: 1034-1269
Range on HMM: 1-234/235.0
NVSKNRFENVYSYDSSRVELtaiP-DKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMD
| .|||....  ||..||.|     ..  ||||||....|||..|..||.||||..|..|||||||. .  .|||||.| |.|  ||  |||.. .|.. 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

VGyDLQVTLV-EQQ-QYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQR
 | |..|.|. ... .  .| |.|. . .. .   .  |...|. .|||||||.... .| .||.|.... ..  |..|||||||||||||..|| . ..
yg.dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LDKQEKdLNIYEFLANMRTMRVLMVQTEAQYVYIHDALS
|...|. ....... ..|. |  |||...||.....|. 
leaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
0046845 (Phosphotyrosine protein) phosphatases II 1324-1580 7.1e-76 250.6 In-house 24-281 (284) alignment 
Range on Protein: 1324-1580
Range on HMM: 24-281/284.0
LSKTNIGKNRFPSkldTLPYDMTRVRLRTASGT---GDYINANHVDGY-----KHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCA
| . |. |||...    |||| .||.|.. .|.   .|||||..||||     ... .|.|||.|...|||| ||||||| .. ||||..|.||..| ||
llpenlsknRykd...ilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekca

KYWPDKvDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsagAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMN-TGNKAITVMCS
.|||.. .|..|||.. |.|.|||....|..|.|.|. ...          ...||.||| .| ..  | . ..||...... . . |  |.. | |.||
qYwple.gevltygdftvtllseevkddytvrtleltnlgy.......tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs

DGIGRTGSFMCMYSVLERIKIES---VADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSFDAYH
.|.|||| | ... .||... |.   . ||....|  |  ||| ||.. ||.|.....|||....  ..
aGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
subfamily_PTPN12_pd Subfamily PTPN12 1025-1273 1.5e-75 248.7 In-house 31-278 (290) alignment 
Range on Protein: 1025-1273
Range on HMM: 31-278/290.0
SYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWP
| .... .||| |||. ..  || |||||. | .. |||||||.|| | . ...||||||||..|. |||||.||...  .||. ...| |  || .|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

RALNETMDVGyDLQVTLVEQQQYV-DYKLKKfLILNTSstGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFIT
   .|.. .| ...||| |...   |. ..  | ....  . .  |. .|. ||||||||. .. .|..|. ||...  |  ||.|||||||||||| |.
eegeeelefg.efevtleeekavdddflirt.Lkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiia

LDSMQQRLDKQEK--DLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT
.| ... | ..    .|.... ....|. |. .|||. ||.... |. |...
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN6_pd Subfamily PTPN6 1008-1274 2.5e-75 248.3 In-house 25-299 (306) alignment 
Range on Protein: 1008-1274
Range on HMM: 25-299/306.0
DLGFEDEYKSFRNIPQ---GSYTTAKLPENVSKNRFENVYSYDSSRVELTaIPDKRGSDYINASFIDGYK--RPKAYIAAQGPLSNTVGDFWRMVWEFQL
  |||.|......  .    | . .. ||| .|||..|.  .| .|| |.  |.  |||||||..|..      |.|||.|| |..|| |||||||. . 
kagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens

PTIVMLTELIERGIDKCTCYWPRALNETMdVGyDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPP
  |||.|. .||| .||. ||| . ....  | ...|| |....  ||.|..... .... .   .| .||| .|||||||.|.  .|.|.. |.. .  
rvivmttkevErgkekCarYWPdeeekee.yG.kisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqee

----EGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQ--EKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITC
    |  |..||||||.||||||| .| . . . |.  . |..|...   .|. |  .||||.|| ... |...||  
leeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
0047943 (Phosphotyrosine protein) phosphatases II 1309-1573 9.4e-75 246.9 In-house 19-272 (273) alignment 
Range on Protein: 1309-1573
Range on HMM: 19-272/273.0
NQVCRQPTEGLLCDALSKTNIGKNRFPSkldTLPYDMTRVRLrtASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEE
..........    || . |. |||...    |||| .||.|   .|. |||||..||||..  .|.|||.|...|||| ||||||| .. ||||..|.|
elllslkplltysvallpenkdknrykd...ilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelve

NEKEVCAKYWPDKVDE-SVTYGKMVVKLVSEEKRPHYIIRKLMLSQEStyinvsagAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNT-GN
...| ||.|||....| |.||||. |.|.|||....|..|.|.|.  .          . ..||.||| .| ..  | . ..||..|... . . .. .|
lgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg........tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

KAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
. . |.||.|.||||.| ... .|.... |   ||....|  |  ||| ||.. ||.|.....|||.
gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 1323-1576 1.3e-74 246.6 In-house 38-279 (317) alignment 
Range on Protein: 1323-1576
Range on HMM: 38-279/317.0
ALSKTNIGKNRFPsklDTLPYDMTRVRLRTASG--TGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPD
|. . |..|||.|   | |||| .||.|   .|    |||||..|||.... .|.|||.|...|||| ||||||| ...||||..|||...| ||.|||.
aelpenkdknryp...dilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl

kvDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEstyinvsaGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMnTGNKAITVMCSDGIGRT
  .|..|||...|.|.|||. .....|.|...          |  ....||.||| .| ..  |.. ..||...... ...   ... . |.||.|.|||
..getltygdftvtllseeelagitlrtlevedl........gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRt

GSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSF
|.| ..| .||... |   ||.. .|  |  ||| ||.  ||.|..|..|||.. .
GtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1001-1287 1.8e-74 245.9 In-house 25-306 (319) alignment 
Range on Protein: 1001-1287
Range on HMM: 25-306/319.0
AKLHSDRDL-GFEDEYKSFRNI--PQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMV
 | . | ||  .| |..   ..  .    | | |..|  |||. |. ..| ..| |  .  . .||||||||..||.|.. |||||||| ||. |||||.
nksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmi

WEFQLPTIVMLTeliergIDKCTCYWPRALNETMDVgYDLQVTLVEQQQYvdYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVR
||..  |||.||       |||. |||   ... .  ....|..||. .   | .... . . .   .  ..| .||| |||.|||   . .. ....||
weyncstivllt......kdkcsqywplkivikeer.fkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvr

QTHPPE--GPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLKIV
  .  |    ...|||||||||||..|.|| . .|. |.|| ...|.|. ..|  |  .||  .|| .|. || |    | . ..   .   
hltskenhranivvhcsaGvGrtGvyivldvlldrm.keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay
0045450 (Phosphotyrosine protein) phosphatases II 1280-1574 9.1e-74 244.2 In-house 8-305 (307) alignment 
Range on Protein: 1280-1574
Range on HMM: 8-305/307.0
TTKRLKIVMDELTKVSEKKSGYEKQLELINQVCRQPtEGLLCDALSKTNIGKNRFPSkldTLPYDMTRVRLRTASGT---GDYINANHV--------DGY
  ..||...  |... . ..|..|. | ...|. ..  |    ||.. |. |||...    |||| |||.| . .|.   .|||||..|        |||
fidalkllllvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykd...ilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

KHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKvDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEstyinvsAGAADHL
..  .|.|||.|..||||| |||.||| .. ||||..|.|...| ||.||||. .|..|||...|.|.|||. ..|..|.| ..          |   ..
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl.......dgtgesr

MVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNT-GNKAITVMCSDGIGRTGSFMCMYSVLERIKIESV---ADVFQYIKGARFNRPGLVQNVVQYEF
.||.||| .| ..  |..  .||..|..... . .. ... . |.||.|.||||.|...| .|.... | .    |... .|  |  ||| |||  ||.|
tvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrf

CHDIILEYIN
.....||...
lyeallelll
0037934 (Phosphotyrosine protein) phosphatases II 1026-1272 1.8e-73 242.3 In-house 2-242 (243) alignment 
Range on Protein: 1026-1272
Range on HMM: 2-242/243.0
YTTAKLPENVSKNRFENVYSYDSSRVELtaipdkRGSDYINASFIDGYKRpkaYIAAQGPLSNTVGD----FWRMVWEFQLPTIVMLTELIERGIDKCTC
...|.||||.||||. ... || ||| |       |||||||..|....|   .|| ||||..|| |    ||||.|| .  .|||||||.|.|  ||  
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPralnETMdVGYDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQT--------HPPEGPPLIVHCSA
|||    ... .  |..|||...... ||.. ..|. |.. ..  . |.|||.|.||||||| . ...|.|.. ||.         . ..| |..|||||
ywp....gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

GVGRTGTFITLDSMQQRLdkqekDLNIYEFLANMRTMRVL-MVQTEAQYVYIHDALSEYI
|||||||.|... | ..|     .....| .. .|..|   .|||. ||.....|| |..
GvgRtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1029-1275 2.4e-73 241.4 In-house 4-245 (250) alignment 
Range on Protein: 1029-1275
Range on HMM: 4-245/250.0
AKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDkCTCYWPRalN
|| |.|  |||. .. ..||||| |      . ||||||||..||.  ||.||.||||..|. ||||||.| .  ||||||.| | .   .. |||   .
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv..e

ETMDVGyDLQVTLVEQQQYVDYKLKKFLILNTSSTGgRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPP-EGPPLIVHCSAGVGRTGTFITLDSM
..   | |..|.| ..... ||. .|. . ... .. .  | ..||..||| |||.  | .|.....|.....  .  |.||.|||||||.|.||..|..
kaekyG.dvtvsllskeefadytkrklklskakkad.erivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

QQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCG
 .|| |.|| .......  .|. |. .|....|||... .. ..... 
lerl.kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1021-1290 6.3e-73 240.7 In-house 12-273 (284) alignment 
Range on Protein: 1021-1290
Range on HMM: 12-273/284.0
IPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTeliergIDKCT
..    | | |..|  |||. .. ..| ..| |  .  . .||||||||| ||.|.. |||.|||| ||. |||||.||..  |||.||       |||.
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcs

CYWPRALNETMDVgYDLQVTLVEQQQYvdYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPE--GPPLIVHCSAGVGRT
 |||   ... .  ....|..||. .   | .... . . .   .  ... .||| |||.|||   . .......||  .  |    ...||||||||||
qywplkivikeer.fkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLKIVMDE
|..|.|| . .|. |.|| ...|.|. ..|  |  .||  .|| .|. || |    | . ..   .   ..|
gvyivldvlldrm.keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpaylee
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1327-1580 8.6e-72 236.3 In-house 8-249 (250) alignment 
Range on Protein: 1327-1580
Range on HMM: 8-249/250.0
TNIGKNRFpskLDTLPYDMTRVRLRTAS--GTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEvCAKYWPdkVDE
 |  |||.    | ...| .|| | . .     ||||| ...||. | ||.|||.|...|.||.||||.|. |..|||| ||.|.||. . .|||  |..
qnkeknry...adiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..vek

SVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsagaADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTGNKAITVMCSDGIGRTGSFM
. .||.. |.| |.|.   |..|||.||...         ||. .| |.|.|.| .   |.  |  |.|....  .| ..||. . | || |.||.|.|.
aekyGdvtvsllskeefadytkrklklskakk........aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafi

CMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSFDAYH
 ...||||.|.| | |||..||  | .||. |.   || |.. |||....|.. | 
aidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
0043336 (Phosphotyrosine protein) phosphatases II 1316-1573 2.3e-71 235.8 In-house 34-277 (278) alignment 
Range on Protein: 1316-1573
Range on HMM: 34-277/278.0
TeGLLCDALSKTNIGKNRFPSkldTLPYDMTRVRLRTASGT--GDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEV
. .    ||.. |. |||...    |||| .||.|   .|    |||||..||||..  .|.|||.|..||||| ||||||. ...||||..|.|.... 
l.dtysiallpenkdknrykd...ilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvk

CAKYWPdkvDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQestyinvsAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMnTGNKAITVMC
||.|||   ..|.|||...|.|..||. ..|..|.| ..          |    ..||..||..| ... | . ..||... .... .  . |... |.|
caqYwp...ggsltygdftvtllkeehlddytvrtlevtn........lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHC

SDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
|.|.|||| |...| .||... |   |... .|  |  ||| ||.  ||.|.....|||.
saGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
DSPc_SM00195 1324-1573 3.4e-71 235.0 In-house 22-262 (263) alignment 
Range on Protein: 1324-1573
Range on HMM: 22-262/263.0
LSKTNIGKNRFPsklDTLPYDMTRVRLRTAS--GTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDK
  | |  |||.    . |||| |||.| .     . ||||||...|.... .. |||.|...|||| ||||||. .. ||||.. |||.|| |..|||..
ekkknksknRyk...nilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

VDESVTYGKMVVKLVSEEKRP-HYIIRKLMLSQESTyinvsagaADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTgNKAITVMCSDGIGRT
 ... |.||. ||||..||.. ..|.|.| |..| .         ..  |||..| || . . |......|.|. .. . . .. .. | |.||.|.|||
sggketfgkisvklvevekkkdeiilrtleltkegk........eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRt

GSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
|.|... ..|.... |.  |.|. .|  | .|||.||.  || |....|||||
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1324-1573 3.4e-71 235.0 In-house 22-262 (263) alignment 
Range on Protein: 1324-1573
Range on HMM: 22-262/263.0
LSKTNIGKNRFPsklDTLPYDMTRVRLRTAS--GTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDK
  | |  |||.    . |||| |||.| .     . ||||||...|.... .. |||.|...|||| ||||||. .. ||||.. |||.|| |..|||..
ekkknksknRyk...nilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

VDESVTYGKMVVKLVSEEKRP-HYIIRKLMLSQESTyinvsagaADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTgNKAITVMCSDGIGRT
 ... |.||. ||||..||.. ..|.|.| |..| .         ..  |||..| || . . |......|.|. .. . . .. .. | |.||.|.|||
sggketfgkisvklvevekkkdeiilrtleltkegk........eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRt

GSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
|.|... ..|.... |.  |.|. .|  | .|||.||.  || |....|||||
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0039614 (Phosphotyrosine protein) phosphatases II 1305-1576 4.9e-71 234.9 In-house 35-292 (297) alignment 
Range on Protein: 1305-1576
Range on HMM: 35-292/297.0
LELINQVCRQPTEglLCDALSKTNIGKNRFPSkldTLPYDMTRVRLRTASGT---GDYINANHVDGYKH-RGAFLATQAPMKETVEDLWRMVWEQWSSSI
|.   ...... .     ||.. |. |||...    |||| .||.| .  |.    |||||..||||..   .|.|||.|..||||| ||||||| ...|
llefeellslkpd..ysiallpenkdknrykd...ilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvi

VMLCNLEENEKeVCAKYWPDKVDesvTYGKMVVKLVSEEKRPHYIIRKLMLSQESTYinvsagaadhLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHN
|||..|.|...  ||.|||....   |||...|.|...|....|..|.| .. ..            ..||.|.|..| ..  | . . ||...... . 
vmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges..........rtvthfqytgwpdhgvppslellleflelvrea

QMNT-GNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSF
. .. ... . |.||.|.||||.| ..| .||... |   ||.. .|  |  ||| ||.  ||.|..|..||... .
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 990-1288 2.4e-70 231.9 In-house 2-293 (315) alignment 
Range on Protein: 990-1288
Range on HMM: 2-293/315.0
PIPVAEFAAHTAKLHSdrDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNT
|||||.| |   | .      | .|.. . . .    ..|. ..| .|||..|.  .||.|| |  | |.  |||||||.| ...  |||||.||||  .
pipvaqfpafvnknrh..talfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

VGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMDVGyDLQVTLVEQQQYVDYKLKKFlILNTSSTggRLDVTHYHFLAWPDHGVPADKTIM
| ||||||.. .  ||||.|.. |    ||  |||    .... |  ..|.|.. ..  |   .|. ..  | .     || ..|  |||.||. . . .
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefG.sikvellsleadtdgvarkl.vtrksee..srtvtqfqftewPdkGvdkqtssl

LAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKqEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLKIVM
| .|. |.  . ..  .|.||||||||||| .|..|.. ... . .. .....|. |.|. |. .|||| .| .|.||. |..   .| ..  ..   .
lklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhl
subfamily_Ptp69D_pd Subfamily Ptp69D 1323-1575 2.9e-70 231.8 In-house 43-288 (307) alignment 
Range on Protein: 1323-1575
Range on HMM: 43-288/307.0
ALSKTNIGKNRFPsklDTLPYDMTRVRLRTASG--TGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPD
.  | |  |||..   |  ..| |||.|..  |  . |||||... |||..  |.| |.|. .|..| |||..|| .  |||| ||.| ... ||||||.
sekkenalknRye...dikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpi

KvdESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEStyiNVSAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTgNKAITVMCSDGIGRT
   . | ||...|||||||| ..||||.| .|.     . |.   |.  |.|.|| .| . . |.  . |||||.|. . . .  .  |.| || | ||.
e..devqygdilvklvseekhsdyiiReldvskkk...eesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrs

GSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINS
| |... |.|...| |  .|.|. .|. | .|. |||.  ||.|..  .|.|.. 
gifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPN3_pd Subfamily PTPN3 1018-1268 9.9e-70 229.6 In-house 25-271 (280) alignment 
Range on Protein: 1018-1268
Range on HMM: 25-271/280.0
FRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDkrgsDYINASFID----GYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIE
.|  |. . ..|..|||.||||. .. .||. ||.|.. .     |||||....    . .  . |||.||||..|. |||.|||| .  .|||||.|.|
yrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlve

RGIDKCTCYWPRaLNETMDVGyDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRlDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGPPLIVHCSA
||  ||  |||.  ..... | ...|.. ....   | |..... .....  |  ...  .||||||||| |.. .| |..|||...  .  |..|||||
rGrvkChqyWPe.tedeleyg.efsvkcekedetksyvlrelvlkdketkeer.kilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsa

GVGRTGTFITLDSMQQrLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDAL
|.|||| .|.|.   . |  ....... . . .||  |  .|||..|| .. .|.
GigrtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeai
Y_phosphatase Protein-tyrosine phosphatase 1331-1571 1.4e-69 229.4 Pfam-A 4-235 (235) alignment 
Range on Protein: 1331-1571
Range on HMM: 4-235/235.0
KNRFPsklDTLPYDMTRVRLRTASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGK
|||..   | |||| |||.|.  .|. ||||||.|.|||.  .|.|||.|.|.|.|| |||||.. ...||||..|||...| ||.|||.. .||.|||.
knRyk...dilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MVVKLV-SEE-KRPHYIIRKLMLSQESTYInvsagaaDHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQmNTGNKAITVMCSDGIGRTGSFMCMYS
. |.|. .|. .  .|..||| |... .         .. .|.|.|| || . . |.. ..||.||... ... .. .. ..|.||.|.||||.|...  
ikvelkekekedekeytlrklelkkkkees.......ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldi

VLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILE
.||... |.  ||.|..|  | .|||.||.. ||.|....|||
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1331-1571 1.4e-69 229.4 In-house 4-235 (235) alignment 
Range on Protein: 1331-1571
Range on HMM: 4-235/235.0
KNRFPsklDTLPYDMTRVRLRTASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGK
|||..   | |||| |||.|.  .|. ||||||.|.|||.  .|.|||.|.|.|.|| |||||.. ...||||..|||...| ||.|||.. .||.|||.
knRyk...dilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MVVKLV-SEE-KRPHYIIRKLMLSQESTYInvsagaaDHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQmNTGNKAITVMCSDGIGRTGSFMCMYS
. |.|. .|. .  .|..||| |... .         .. .|.|.|| || . . |.. ..||.||... ... .. .. ..|.||.|.||||.|...  
ikvelkekekedekeytlrklelkkkkees.......ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldi

VLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILE
.||... |.  ||.|..|  | .|||.||.. ||.|....|||
lleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1296-1582 3.9e-69 227.8 In-house 17-287 (287) alignment 
Range on Protein: 1296-1582
Range on HMM: 17-287/287.0
EKKSGYEKQLELINQVCRQPTEglLCDALSKTNIGKNRFPsklDTLPYDMTRVRLRtaSGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQ
. . |...|  ...|| ... |  .  .... |  |||.    . |..|  || |.      ||||| ..||||.. ||.....|| .|. ..|......
kgnegfknqftvleqvtqrede..vthniasqnkdknRlt...qilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnfWkliddr

WSSSIVMLCNLEENEKEVCAKYWPDKvdESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsagAADHLMVTQFHYVNWAEDEKPKDETPLLKLID
  . |||||...||..||| .|||..  .||..|.  ..|..||.  .||.||| . ...        |.|...|.|... || .  | ..    | .|.
nvtaivmlcqekendeevcyqyWpee..ksvvlGeyniellneevnagyierklevknknk.......agdkqqvkqyqitnWdstgkvtepqtillvie

QLLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSFDAYHNF
.  ..|   || .| | |||..||.. |. .   ... | | | |||| .|  |  .|| || | ||.|  ||.|||..||..| .|
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_PTPRA_pd Subfamily PTPRA 1322-1573 6.7e-69 227.3 In-house 52-295 (330) alignment 
Range on Protein: 1322-1573
Range on HMM: 52-295/330.0
DALSKTNIGKNRFpskLDTLPYDMTRVRLRTASGT--GDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWP
 |  . |  |||.   .. |||| .|| | . .|.   ||||| ..||||..  |.|.| | .|||||.|||.||| |..|||| .|.| ..| ||.|||
laskeenkeknrv...vnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

DkvDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTYINvsagAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTGNkAITVMCSDGIGR
|  . .||||.. |..  |.   .| .||... | .   .      .. .|.|||.  | .   | .   .|||. .. . . .... .|.| || |.||
d..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatr....ekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGr

TGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
||.|. . .||||.| | . |||. .|  | .|| .||   ||||.. ..||| 
tGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 990-1338 1.1e-68 226.6 In-house 1-344 (515) alignment 
Range on Protein: 990-1338
Range on HMM: 1-344/515.0
PIPVAEFAAHTAKlhSDRDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNT
|.|.|.| |  .|  . .   | .|.. .        | |.   | .|||..|.  |||.|| |  | |.  |||.|||.| ...  |||||.|||.  .
plplaqfPafvnk..nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

VGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMDVGYdLQVTLVEQQQYVDYKLKKFLILNTSStggRLDVTHYHFLAWPDHGVPADKTIM
| ||||.|.. .  ||.|.|.| |    ||. |||    ...  |. ..| ||  .   .   .|. .|  .       || .||  |||.||| . . .
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGs.ikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssl

LAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLKIVMD
| .|. |.  |     |||.|||||||||| .|..||.  .  |. . .....|. |.|  |. .|||. || .|..|. |..   .| .    .   ..
lklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha.kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlq

ELTKVSE--KKSGYEKQLELINQVCRQPTEGLLCDALSKTNIGKNRFPSKL
.|    .   .|   |. . .. .| .|       . .. |  |||. ..|
dlhssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 991-1275 1.2e-68 226.1 In-house 2-286 (290) alignment 
Range on Protein: 991-1275
Range on HMM: 2-286/290.0
IPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIPQGS-YTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRG--SDYINASFIDGYKRPKAYIAAQGPLS
||| .|. ..|. |.  . ||....|.. .  .    |..  ..|  .|||.|.  ||  |. |  |....    .||||..|.|||  |.|||.|||.|
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

NTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRAlnETMDVGYdLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHG-VPADK
||. |||...|. . . |||||. || | .||  ||| .  .| ..|.  ...|...... .|  .|. . |..|.| .  ||.|.. .|...| |.. .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkayge.fsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpq

TIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCG
||.|.. ..... . .   ...||||..|||...|....   ..  |.|   .... | ..|. .  .|||. || .|.. . .|... 
tillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkc.ktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
0042113 (Phosphotyrosine protein) phosphatases II 1325-1574 3.6e-67 221.6 In-house 6-244 (245) alignment 
Range on Protein: 1325-1574
Range on HMM: 6-244/245.0
SKTNIGKNRFPSkldTLPYDMTRVRLRTASGT--GDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDkv
 . |. |||...    |||| |||.|   .|    |||||..||||.. . |.|||.|..||||| |||.||. ...||||...||.... ||.|||.  
lpenkdknrysd...ilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

DESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEstyinvsaGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTGNKAITVMCSDGIGRTGS
.||.|||...|.|.|||. ..|..|.|... .        |   ...|...||..| ..  | .   ||.... ... . ...|. . |.||.|.|||| 
gesltygdftvtllseehlddytvrtlevtnl........gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

FMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
|...| .||... |   .... .|  |  ||| ||.  ||.|.....||...
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 991-1278 5.5e-67 220.8 In-house 2-284 (287) alignment 
Range on Protein: 991-1278
Range on HMM: 2-284/287.0
IPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIPQ--GSYTTAKLPENVSKNRFENVYSYDSSRVELTaipdKRGSDYINASFIDGYKRPKAYIAAQGPLSN
||| .|.  .|| |   . ||.. .. . .. |   . | .  ..|  |||....  .|  || |     ..  |||||.||||||  ||.|.|..|..|
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNetMDVGyDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHG-VPADKT
|. .||..... . ..||||... |   ..|  |||   .  . .| . ...|...... .|  .|. . |....| .. |. |.. .|...| |.  .|
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlG.eyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

IMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTS
|.| . ..... . .   ...||||..|||...|.  .   ..  |.|  ..... | ..|  .  .||| .|| .| |.. ||.....| 
illvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1013-1273 8.6e-67 220.1 In-house 6-269 (274) alignment 
Range on Protein: 1013-1273
Range on HMM: 6-269/274.0
DEYKSFRNIPQGS-YTTAKLPENVSKNRFENVYSYDSSRVEL-TAIPDKRGSDYINASFIDGYK-RPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLT
| .| | ..|        ... . .|||....   . ||| | .. ...  |.|||| .| ||. . |||.|.||||.||| |||||... . . |||||
dlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmlt

ELIERGIDKCTCYWPRALNETMDVGY-DLQVTLVEQQQYVDYKLKKFLILNTSStggRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGP---
.| |.  .||. |.| | .  ..  | |.... ..  .  ||...|........   . .|.|| . .|||| .| | . .| ... |....  |     
klkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenakla

PLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT
| .||||||.|||| ||. .   ..| ..|. ... .  .|.|  |  ||||. || .|| ||..|  
pvvvhCsaGiGrtGcfiaisiavrql.reeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0040439 (Phosphotyrosine protein) phosphatases II 1325-1574 1.2e-66 220.2 In-house 8-247 (249) alignment 
Range on Protein: 1325-1574
Range on HMM: 8-247/249.0
SKTNIGKNRFPSkldTLPYDMTRVRLRTASG--TGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDkv
 . |. |||.|.    |||| .||.|   .|   .|||||...|||..  .|.|||.|..||||| |||.||. ...||||..|.|...| ||.|||.  
lpenkdknrypd...ilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..

DESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEstyinvsaGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNT-GNKAITVMCSDGIGRTG
..|..||...|.|.|.|. ..|..|.|.|.          .  ....|....|..| ..  |..  .||..|..... . ..  .. . |.||.|.||||
ggsleygdftvtllsvevkddytvrtleltnl........ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

SFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
 | ..| .||... |   |.....|  |  ||| |||  ||.|.....||...
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1295-1579 3e-66 218.3 In-house 16-289 (290) alignment 
Range on Protein: 1295-1579
Range on HMM: 16-289/290.0
SEKKSGYEKQLELINQVCRQPTeglLCDALSKTNIGKNRFPsklDTLPYDMTRVRLRTASGTGD----YINANHVDGYKHRGAFLATQAPMKETVEDLWR
.. ..|...| . ...  .. |      .|.. |  .|||    ....||  |. ||  ||  |    |||| ...|||.. ...|||.|...|. | |.
akgnegfrnqfkmldsgeseht...vtvgltssnkllnRfa...nivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWk

MVWEQWSSSIVMLCNLEENEKEVCAKYWPDKvDESVtYGKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsaGaADHLMVTQFHYVNWAEDEKPKDETPL
..|.. .. ||||.|  |..|..| .||||. | .  ||.. .||..||.  .||.||| . ....      . ... .|||..  || ...| ....  
liwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknkns......a.gakqsvtqyqitnwdstgkvtnpqti

LKLIDQLLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSFDAY
| .| .  ..|  .||..| | |||..||.. |. ..  ... |.| | |||| .|  |  .||.|| |.||.. ..|.|.|..||..|
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
0045098 (Phosphotyrosine protein) phosphatases II 1319-1574 3.6e-66 218.7 In-house 24-273 (278) alignment 
Range on Protein: 1319-1574
Range on HMM: 24-273/278.0
LLCDALSKTNIGKNRFPsklDTLPYDMTRVRlrtasgtgDYINANHVDGYkhRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYW
   .||   |. |||..   | ||||..||.        |||||...|||  . .|.|||.|...||.| |||.||. ...||||..|.|...| ||.||
eitpalylgnldknRyk...dilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PDkvDESVTYGKMVVKLVSEEKRPHYIIRKLMLsqesTYINVSAGAADHLMVTQFHYVNWAEDEKPKDE--TPLLKLIDQLLHNQM------------NT
|.  ..|.|||...|.|.|||  ..|..|.|..    |...|       . ||..||..| . . | ..  ...|.|...... .             . 
pe..ggsltygdftvtllseevlddytlrtllv....tnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

GNKAITVMCSDGIGRTGSFMCMYSVLERIkiESVADVFQYIKGARFNRPG-LVQNVVQYEFCHDIILEYIN
... . | || |.|||| . ..| .||..  |.. |.....|  |  |||  |||  ||.|... .||...
sggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1297-1573 4.2e-66 217.9 In-house 19-279 (288) alignment 
Range on Protein: 1297-1573
Range on HMM: 19-279/288.0
KKSGYEKQLELINQVCRQPTEgllCDALSKTNIGKNRFPsklDTLPYDMTRVRLRT--ASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWE
...|.... . . .. .. ..   . .    |  |||..   . ||||..||.|.      . |||||...||.|.. ...|||.|. .||.| |..|.|
nrtgfseeynsLaalektksv...tagrlavnakknRyr...nilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

QWSSSIVMLCNLEENEKEVCAKYWPDKvDESVTYGKMVVKLVSEEKRPHYIIRKLMLSqestyinvsaGAADHLMVTQFHYVNWAEDEKPKDETPLLKLI
. .| |||| .| |..|. | .||||. |. . ||.. |.||....  ... |||.|              ..| .||..|  |.... |....|||.|.
nktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..........kkkteleitqyqylaWpdhgvPeskapllell

DQLLHNQMNTgNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
.|.  .. .   . |.| ||.|.|||| |. .  ...... | . ||.  ..  | .|. |||.. ||||.....|. |
rqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN13_pd Subfamily PTPN13 1012-1270 2e-65 215.8 In-house 14-267 (273) alignment 
Range on Protein: 1012-1270
Range on HMM: 14-267/273.0
EDEYKSFRNI-PQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDkrgsdYINASFIDG--YKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVML
..|.| .|.. |. . ...|  || .|||. ||  || .||.| .        |||||.|     |    |||.|||| .|| |||.|||| .   |.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TELIERGIDKCTCYWPRALNETMDVGYDLQVTLVEQQQYVDYKLKKFLIlNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPpEGPPLI
|   |.|  ||  |||   |... |   |.|.|...|.. ....... . . | .|   .|.| .| .|||||||.  . .| |...||. .  .  |..
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralav.kdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPiv

VHCSAGVGRTGTFITLDSMQQRLDkQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSE
||||||.||.||.||.| . . .. ..|.... | . ..|  |  .|||. ||.... |. |
vhcsaGiGrsGtlitidvvlglie.rdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_PTPRG_pd Subfamily PTPRG 1295-1575 2.2e-65 216.0 In-house 15-289 (563) alignment 
Range on Protein: 1295-1575
Range on HMM: 15-289/563.0
SEKKSGYEKQLELINQVCRQpTEGLLCDALSKTNIGKNRfpsKLDTLPYDMTRVRLRTASG---TGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRM
.. . |.... | ... . . ..     .  . |  |||   .|. ..|| .||.|.  .|   . ||||||..|||..  ||.||| |.|.|..| |||
adgdigfseefealqsetis.kdldaehsqkpenkrKnR...ylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrm

VWEQWSSSIVMLCNLEENEKEVCAKYWPDkvDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQesTYINVSAGAADHLMVTQFHYVNWAEDEKPKDETPLL
.||| .. |||. ||.|.... |  |||   |||.|||.. |.|..||.   | .|.|.. .  . ..    . ....|.|.|| .| .   |. ..| |
iWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlvikn..lklkkkkqcdteklvrqyhytkWPdhgvPehslpvL

KLIDQLLHNQMN-TGnkAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINS
. . .    ... .|   |.| || |.|||| .. . ..|..|. |.. .||. .|  | .|. |||.  || | ||..|| |.|
ifvkkssaankaeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPRK_pd Subfamily PTPRK 1325-1571 3e-65 215.1 In-house 40-275 (314) alignment 
Range on Protein: 1325-1571
Range on HMM: 40-275/314.0
SKTNIGKNRFpskLDTLPYDMTRVRLRTASGT--GDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKV
 . |  |||.    | |.|| .||.| |  |    |||||. .|.||.  ||..|| |..|||.|.||.|... ..||||| .| |. .  | ||||.. 
kdenreknrs...gdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

DEsvtYGKMVVKLVSEEKRPHYIIRKLMLSQestyinVSAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNtGNKAITVMCSDGIGRTGS
.    ||.. |.||. |    ...| . ...      .. |  .. .| ||....|.. . |. .| ||||. .. . | . ..  | | || | |||| 
ev...ygdikvelvetellaelvvrifrvek......largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGt

FMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILE
|. . .||. |. |.| |||. .|  | ... .|.   || |..|.|||
fiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1018-1273 7.2e-65 213.6 In-house 1-265 (270) alignment 
Range on Protein: 1018-1273
Range on HMM: 1-265/270.0
FRNIPQGSYTTAKLPENVS---KNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYK-RPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIE
|....... .. .||| .     ||....     .|| |  . ..  . |||| .. |.. ..|.||||.||| .|. .||||.|| . ..|||.|.| |
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

RGIDKCTCYWPRALNETMDVGY-DLQVTLVEQQQYVDYKLKKFLILntsSTGGRLDVTHYHFLAWPDHGVPADKT------IMLAFIRRV---RQTHPPE
.| .|| .|||   .|.... . ...|. .....   | |..  .    ..| .  ..|... .||||||| ..        .|. .| |   .. .  .
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldka

GpPLIVHCSAGVGRTGTFITLDSMQQRLDKQEKdLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT
. ||.||||||||||||.|.|| . . |....| ... . ....|  |. .||.  || ... |..||. 
e.PllvHcsaGvgRtGtlialDiavrlLeetkk.vdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 992-1288 3.6e-64 211.9 In-house 6-304 (325) alignment 
Range on Protein: 992-1288
Range on HMM: 6-304/325.0
PVAEFAAHTAKLHSDRDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVG
 | ..  |  | ... . ||  |..   .    ....| .|||..||||.|| ..| ||| | .  |.  |||||||..  .|. . ..||| ||..|..
avvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

DFWRMVWEFQLPTIVMLTELiERGIDKCTCYWPRALNETMDVGyDLQVTLVEQQQYVDYKLKKFLILNtSSTGGRLDVTHYHFLAWPDHGVPADKTIMLA
|.||.| ... . .|.| || . | |.|. |||. . ..   |  |.| |.  ... ||  ... . .  . |  . |  ... .|.| ||.   . ...
dlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgksktfG.glevklrtieeisdyvhrvldvkq.vkkGetrsvkqfqlqswddmGvqkrpatlis

FIRRVRQTHP------PEGPPLIVHCSAGVGRTGTFITLDSMQQRLDkQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLK
... | . .           |..|||||||||||.||.| |. ...  .|  ..|..|. ..|  |  ||.|  ||. |..|| |.. .|.| .    ..
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvi.eesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfe

IVM
  .
akl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1297-1573 8.7e-64 210.4 In-house 22-279 (315) alignment 
Range on Protein: 1297-1573
Range on HMM: 22-279/315.0
KKSGYEKQLELINQVCRQPteglLCDALSKTNIGKNRFpskLDTLPYDMTRVRL--RTASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWE
 | |.... | |     .|    |  |    |  |||.    . ..|| .||.|         ||.||| .|||...  ..|.|.|  ..|.|.||.|.|
tkngfkqdyesipggqlhp....ldvakkienkqknry...iniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfe

QWSSSIVMLCNLEENEKEVCAKYWPDKvdeSVTYGKMVVKLVSEEKRPHYIIRKLmlsqestyinvSAGAAD-HLMVTQFHYVNWAEDEKPKDETPLLKL
.  . |||| || |.||. . ||||||    |.|||. | ..|||.  .| .| |           |    |    | |.||  | . . ||  .||..|
edigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl...........svvfgdnirevvqlhytswpdmgvpkytiplmnl

IDQLLHNQMNTGnKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
| .    . |.   || | ||.|.||||.|... .||.....| . ||...|.| | || ..|| . ||.| .|..|| .
irtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_PTPRB_pd Subfamily PTPRB 1300-1574 5.7e-63 207.7 In-house 26-286 (293) alignment 
Range on Protein: 1300-1574
Range on HMM: 26-286/293.0
GYEKQLELINQVCRQPTeglLCDALSKTNIGKNRFPsklDTLPYDMTRVRLRT--ASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWS
.. .. | ...| .. .      | ...|  |||.    . ||||..||.| .   . . ||||||...||. .  |.||| |. |||.|.||||||. |
rfseeyeelkavgkdqa...vkaaelavnraknryt...nilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekks

SSIVMLCNLEENEKEVCAKYWPDKVdESVTYGKMVVKLVSEEKRPHYIIRKLMLSQestyinvsagAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQL
| |||| .| |. |. | .|||..  |.|.||.. |.||.||.  ...||.|....          . ..  |.|.|.. |.. . |.. ..||... ..
siivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek..........ekeerkvrqyhftsWpdhgvPektktlldfvrtv

LHNQ-MNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
 ...  .. .. |.| || |.|||| |...  .|..|. | . |.|  .   | .|  |||.. || | |. .|....
reaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 986-1281 1.6e-62 206.3 In-house 6-293 (297) alignment 
Range on Protein: 986-1281
Range on HMM: 6-293/297.0
ERwEPIPVAEFAAHTAKlhsDRDLGFedEYKSFRNIPQG---SYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRpkAYIAA
|| .|||...||.   |   .|.  .  ... |. .|.    . |.|.   | .|.|..|.  ||||||.|  . |.  |||.||||. |.|    .|. 
er.rpiplsdfatlvqk...nrhtdv..fseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlitt

QGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIdKCTCYWPRALNETmdVGyDLQVTLVEQQQYVDYkLKKFLILNTSSTGGRLDVTHYHFLAWPDHGV
| |  .|| |||.||.. |  |||||... ||   ||. ||.     |   | |. |.|   ..   . .|. | .. ...  |  |  |.|. |||. |
qmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fG.dvsvvllsvsereGf.ikrelevtkgkakarrvvkqyqfveWPdkav

PA--DKTIMLAFIRRVRQTHPPEGP-PLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSM
.   . . .| .|  ||...  .   ||.|||.||||||| ..|.||.  .  |.||...|....  .|  |. .|||. || ... |. |.. . || .
erkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaea.krekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtri

TT
 .
qa
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1314-1571 1.8e-61 203.2 In-house 43-289 (319) alignment 
Range on Protein: 1314-1571
Range on HMM: 43-289/319.0
QPTEGLLCDALSKTNIGKNRFPSK-LDTLPYDMTRVRLRTASGT--GDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCnleene
 .  |      . .|. .|.   .  . |..| ..|.|.   |    ||||| .|.||...  ..|.| |...|..|.|||.||. .|.||.|       
acklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......

KEVCAKYWPDKVDESVTYGKMVVKLVSEEKRphYIIRKLMLSQESTyinvsagAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQL--LHNQMNtGNKA
|. |..||| |...    .|. |..| | .   |..|.. ||...          |   .||||.  | .  .|.  ..|..|....  |....| ... 
kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgk.......ekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsken.hran

ITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILE
| | || |.|||| .. .  .|.|.| |.  ||...... | .|. |||..||| |..  .||
ivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN1_pd Subfamily PTPN1 1025-1279 3.2e-61 201.6 In-house 23-280 (290) alignment 
Range on Protein: 1025-1279
Range on HMM: 23-280/290.0
SYTTAKLPENVSKNRFENVYSYDSSRVELTaipdKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWP
. ..|||||| ..||. .|  || ||..|     .   ||||||...  .  . || .||||.|||. ||.|||| .  ..||| ...|..  ||. |||
ptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

RALN-ETMDVG-YDLQVTLVEQQQYVDYKLKKFLILNTSsTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTH--PPEGPPLIVHCSAGVGRTGT
.  . ... .    |.|.|......  |..... . | . |    ...|.|...||| |||   . .| |. .||..    ..  | ..|||||.||.||
qgeeekellledtklkvkliseerksyytvrllelenlk.tqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FITLDSMQQRLDKQEK--DLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT--CGDTSM
|. .|..  ...|...   ..| . | ..| .|. ..||  |  . . |. | .    ||.|.
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1327-1571 1.8e-60 199.9 In-house 24-253 (284) alignment 
Range on Protein: 1327-1571
Range on HMM: 24-253/284.0
TNIGKNRFpskLDTLPYDMTRVRLRTASGT--GDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCnleeneKEVCAKYWPDKVDE
 |  |||.    . |..| ..|.|.   |    ||||| .. ||...  ..||| |...|..|.|||.||. .|.||.|       |. |..||| |...
qnkdknri...ghilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

SVTYGKMVVKLVSEEKRphYIIRKLMLSQESTyinvsagAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQL--LHNQMNtGNKAITVMCSDGIGRTGS
    .|. |..|.| .   |..|.. ||...          |   ..|||.  | .  .|.  ..|..|....  |....| ... | | || |.|||| 
keerfkvkvdsveesee..yvvrdielsedgk.......ekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsken.hranivvhcsagvgrtgv

FMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILE
....  .|.|.| |.  ||...... | .|. |||..||| |..  .||
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0037934 (Phosphotyrosine protein) phosphatases II 1324-1573 3.4e-59 195.7 In-house 6-242 (243) alignment 
Range on Protein: 1324-1573
Range on HMM: 6-242/243.0
LSKTNIGKNRFPSkldTLPYDMTRVRLrtaSGtGDYINANHVDGYKHrgaFLATQAPMKETVED----LWRMVWEQWSSSIVMLCNLEENEKEVCAKYWP
|.. |. |||...    |||| .||.|   .| .||||||.......   . |||.|..|||||     |||.||. ...||||..|.|...| ||.|||
llpenlsknrysd...ilpydhsrvkl...eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dkvdESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTYINVsagaadhLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMN-------TGNKAITVM
    ..||||...|.|.|||  ..|..|.|.|.  ...  .       ..|...||..| .   | . ..||...|..   . .        ... . |.
....gevtygdftvtllseehlddytvrtlllenldlddlt.......rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVH

CSDGIGRTGSFMCMYSVLERIkieSvADVFQYIKGARFNRPG-LVQNVVQYEFCHDIILEYI
|| |.|||| . ..| .|...   .  |.....|  |  |||  ||.  ||.|.....||..
CsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1029-1268 1e-58 193.3 In-house 3-237 (239) alignment 
Range on Protein: 1029-1268
Range on HMM: 3-237/239.0
AKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYK-RPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRAL
||   | .|||. |. .|| ||| |  . .   |||||||..  |   ||||||.|| .. . ||||||.|. .   ||||| |||    ||  ||| . 
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

NETMdvgyDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLdVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSM
..      .|.||| . . . || .. |.. .   |  |  | .|||  |||.|||   | .| . |.. .   |   | ..||||||||||.|. .|.|
skyc....nlrvtlrktevfadyiirtfvmsqvgqteery.vyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam

QQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDAL
 ..  |..| ..|....  .|  |  ||||  |||.|| |.
lrqa.kkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1030-1269 1e-58 193.3 In-house 3-237 (239) alignment 
Range on Protein: 1030-1269
Range on HMM: 3-237/239.0
KLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYK-RPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALN
|   | .|||. |. .|| ||| |  . .   |||||||..  |   ||||||.|| .. . ||||||.|. .   ||||| |||    ||  ||| . .
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

ETMdvgyDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLdVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQ
.      .|.||| . . . || .. |.. .   |  |  | .|||  |||.|||   | .| . |.. .   |   | ..||||||||||.|. .|.| 
kyc....nlrvtlrktevfadyiirtfvmsqvgqteery.vyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

QRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALS
..  |..| ..|....  .|  |  ||||  |||.|| |. 
rqa.kkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_PTPN14_pd Subfamily PTPN14 1023-1272 2.3e-58 192.6 In-house 38-296 (300) alignment 
Range on Protein: 1023-1272
Range on HMM: 38-296/300.0
QGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKrGSDYINASFIDGY--KRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCT
.. ..|||||||..||||..|  |. .||||..  ..  ..||||| |      . . ||.||||| .|| |||.|||| ..  |||||| .| | .|. 
dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

CYWPRALNETMDVGYDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVR---Q----THP--PEGPPLIVHC
 |.|.  ..   | ..      . ..  |    . | |.   .. . .| |  .  ||||||| | . .| ....|.   .    . .   . ||..|||
kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhC

SAGVGRTGTFITLDSMQQRLDKQEkDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
||||||||  |. | . . |...| ...| . || .|. | |.||| ||| .....| .|.
saGvGrtGvlilsdlliatlehne.eidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1322-1575 3.3e-58 192.3 In-house 42-290 (325) alignment 
Range on Protein: 1322-1575
Range on HMM: 42-290/325.0
DALSKTNIGKNRFPsklDTLPYDMTRVRLRTA--SGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEqWSSSIVMLCNLEENEKEVCAKYWP
 |    |. ||||.   . ...| .|| | |   ..  |||||...  .| .  |||.|||. .|..||||.| . | .|.|.. |  ...|. ||.|||
vamkpenkaknrfk...nvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvld.Wrcsvvvvlneldlgkdrcavywp

DKVDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQestyinVSAGaaDHLMVTQFHYVNWA---EDEKPKDETPLLKLIDQlLHNQMNT---GNKAITVMC
... .|.|.| . |||.. |.   |. |.| . |      |. |  . . | ||..  |     ...|    ..|.|... .......   .   | | |
kemgksktfGglevklrtieeisdyvhrvldvkq......vkkG..etrsvkqfqlqswddmGvqkrpatlisilqlvka.vservtantkastpilvhc

SDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINS
|.|.|||| |...||.|...  ||  |.|...|  | .|| .|. | || .... . |.. |
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1033-1268 4.3e-58 191.3 In-house 2-235 (237) alignment 
Range on Protein: 1033-1268
Range on HMM: 2-235/237.0
ENVSKNRFENVYSYDSSRVELTAIPDKrgSDYINASFIDGYK-RPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRAlNETM
||  |||. |. .|| ||| |     .  ||||||....|.   || |||||||| ..  |||.|||. .   ||||| |||.   ||  ||| . ..  
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpa

DVGyDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRV--RQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQq
  |  | |.|  .... || .. .|. .  .  .   .  |.| .|||.|||   . .| | ...  |  | .|  | |.|||||||||| |. .|.|  
ayg.vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml.

RLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDAL
|  |..| ..||... ..   |  ..||. |||.||...
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_PTPRN_pd Subfamily PTPRN 1025-1271 1.2e-57 189.9 In-house 47-291 (297) alignment 
Range on Protein: 1025-1271
Range on HMM: 47-291/297.0
SYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFI-DGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYW
. ..|| ..||.||| ..| .|| |||.|..  ..  |||||||.| |   |  ||||.||||..|| |||.||||     ||.||.| | |. .|. ||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PRALNETMDVgydLQVTLVEQQQYV-DYKLKKFLILNTSSTGGRlDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFI
|   .|. ..    .| || .  .  || .. | . |  ..  |  || .|||.||..||||    .| | |.| ...     |..||||.|.||||..|
pdeGsevyhi...yevhlvsehiwcddylvrsfylknlqtsetr.tvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyi

TLDSMQQRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEY
 .| . .|| |  |...|   |  .|  |  .|.|..|. ..  |..| 
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_PTPN6_pd Subfamily PTPN6 1279-1575 1.3e-57 190.1 In-house 4-299 (306) alignment 
Range on Protein: 1279-1575
Range on HMM: 4-299/306.0
MTTKRLKIVMDELTKV--SEKKSGYEKQLELINQVC-RQPTEglLCDALSKTNIGKNRFPSkldTLPYDMTRVRLRTASGTG-DYINANHVDGY--KHRG
. .|...  ..||.|   | .|.|.|.. | ..|   ..  .    ..  ..|  |||. .    ||.| ||| |.  | .| |||||| ...   ... 
llakeieqrvselekeeeslekagfeeefeelqqeeakklls..rkegakpenkeknrykn...ilPfDhtrvilkepsvpgsdyinanyikkevkgsdk

AFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVtYGKMVVKLVSEEKRPHYIIRKLMLSQEstyinvsAGAADHLMVTQ
...|||  ...||.| |||||.. |  |||. .  |  || ||.||||. ...  |||. |. |||..  .||.|.|..|..         . ..  | |
syiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk.......kkkkeerevfq

FHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTG---NKAITVMCSDGIGRTGSFMCMYSVLERIK---IESVADVFQYIKGARFNRPGLVQNVVQYEFCH
.|. .| .   |||   .|...... ..| ..    . .| | ||.||||||.|. .  .|. |.   ..   |. . .| .|  | ||||   || | .
yhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvy

DIILEYINS
 .| .||..
kaikkyiet
subfamily_PTPN12_pd Subfamily PTPN12 1323-1574 1.3e-57 189.9 In-house 35-278 (290) alignment 
Range on Protein: 1323-1574
Range on HMM: 35-278/290.0
ALSKTNIGKNRFPsklDTLPYDMTRVRLRTASGTG--DYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPD
. ...|. |||.    | ||||..|| |.. ...   ||||||.. | . . ...|.|.|. .|..| |||.||.  . .||.|.. |..|  |..|||.
gekeenvkknryk...DilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

KVDESVTYGKMVVKLVSEEKRP-HYIIRKLMLSQEstyinvsagaADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMnTGNKAITVMCSDGIGR
...|....|.. |.| .|..    ..|| | . ..           .. .|.|||| .| . . |. ...||.||... . |  . .. . | || |.||
egeeelefgefevtleeekavdddflirtLkveaq..........kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGr

TGSFMCMYSVLERIKIESV---ADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
||  . .  | | .| | .    |||. .   | .|. |||   |||. .  ..|...
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 989-1281 3.1e-57 188.8 In-house 2-245 (392) alignment 
Range on Protein: 989-1281
Range on HMM: 2-245/392.0
EPIPVAEFAAHTAKLHSdrDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSN
.|||||.| |   | .      | .|.. . . .    |.|. . |. |||..|.  |||.|| |  | |   |||.|||.|....  |||||.||| . 
qpipvaqfpafveknrh..salffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa

TVGDFWRMVWEFQLPTIVMLTELIERGidkctcywpralnetmdvgydlqvtlveqqqyvdyklkkflilntsSTGGRLDVTHYHFLAWPDHGVPADKTI
.. ||||||....  ||.|.|.| |                                                       |. .||  |||..||   . 
slddfwrmvfqenvttiamvtklkegd..............................................kgddartvaqfhftewPdkdvpkhtss

MLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRlDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTT
.| ||. |.  .     |||.||||||||||  |..||.  .  |. . .....|..|.|  |  ||||. || .|. |. | .   .| .  
llkfikevkadfGqythpliihcsagvgrtgvvisidsvvah.akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipv
subfamily_CG7180_pd Subfamily CG7180 1296-1574 7.4e-57 187.2 In-house 10-291 (296) alignment 
Range on Protein: 1296-1574
Range on HMM: 10-291/296.0
EKKSGYEKQLELINQVCRQPTEGLLCDALSKTNIGKNRFPsklDTLPYDMTRVRLRTASGT--GDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVW
.|.  .. . .|. ..  . . |    .| |.|..||| .   ...||| .|| |..  |    ||||| .||.. .  ... |.||.||||.. ||.|.
dkrrkfrveyklelkltprleigdCagglrkenreknrdv...kvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvy

EQWSSSIVMLCNLEENEKeVCAKYWPDKVdeSVTYGKMVVKLVSEEKRPHYIIRKLMLSQE--STYINVSAGAADHLMVTQFHYVNWAE-DEKPKDETPL
.. .|..|.|..  . .|  . .||| |      ||...|..|.|.. ..  ||.. | ..  ..  .     |.  .|..|..  |   |. |   . |
deeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnal

LKLIDQLL--HNQM--NTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
..|. .     ...  .  .. . |..||| .|.| .. .   || ...|   |||...|  | .||.||.|| .| .. |..||.. 
ielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1326-1573 3.2e-56 185.5 In-house 41-276 (515) alignment 
Range on Protein: 1326-1573
Range on HMM: 41-276/515.0
KTNIGKNRFPsklDTLPYDMTRVRL--RTASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVD
. |  |||.    . |||| .||.|     .   ||.|| .. ...   |..|.|.| | .|.|.||.|...  . |.|. .|.|..|  |.||||||  
einfkknryk...nilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

ESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEStyinvsagaaDHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLhNQMNTGNKAITVMCSDGIGRTGSF
.|| .|.. |.||| |     |.||| . ...          |   |||||. .| .   ||. . ||||| ..   . .  . .. . || |.|||| .
dsvkfGsikvelvsleactggikrkltvlkgd..........dsrtvtqfhfteWPdkGvpkhtssllklikevk.adhgqythpliihcsaGvGrtGvv

MCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
. . ||. ..|   . |||....  | .|| |||   || | ....||..
isidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPN23_pd Subfamily PTPN23 1024-1268 4e-56 185.0 In-house 35-276 (288) alignment 
Range on Protein: 1024-1268
Range on HMM: 35-276/288.0
GSYTTAKLpeNVSKNRFENVYSYDSSRVELTaipdKRGSDYINASFIDGYK-RPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCY
 | . |||  ...|||....  ||..|| |     .   |||||||. .       .||.|.|| .|..|||.||.| . ..||||..  |.|  |.  |
rsiaiakl..yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrY

WPRALNETMDVGyDLQVTLVEQQQyVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQ----THPPEGPPLIVHCSAGVGRT
|| . .||.  | ||.||| ....  ..  .. |.|.| ..    .|.| .. .||..||||    .|.|.  |..    .. .   ||.||||||||||
wPedkgetvkfg.dlsvtlksvre.tethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRt

GTFITLDSMQQRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDAL
|.|  . .  . |.|..  |.| . .  .|. |  |||...|.    .| 
gvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1331-1574 2.3e-55 182.6 In-house 31-269 (274) alignment 
Range on Protein: 1331-1574
Range on HMM: 31-269/274.0
KNRFPsklDTLPYDMTRVRLRTASGTG---DYINANHVDGYKH-RGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDE--
|||.    . || . .|| |...|..    .|||||.. ||..   |..||| |. .||.|.|||.... .. |||| .|.|.... ||.|.||. |   
knryk...tilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

SVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTYINvsagaadhlmVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTGNK--AITVMCSDGIGRTGS
| .||.. .| ..  .| .| .|||.|.. .   .          |. . | .| . . |.| ..||.|...  ... .. .|  .. | || |||||| 
serygdveikvekiverndysvrklvlkylerers..........vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGc

FMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
|. .   . ... |.| ||.. .   | .| |.||.  |||. | .. .| .
fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1325-1577 3.9e-55 182.1 In-house 48-288 (297) alignment 
Range on Protein: 1325-1577
Range on HMM: 48-288/297.0
SKTNIGKNRFPsklDTLPYDMTRVRLRTASGT--GDYINANHVDGYKHrgAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKeVCAKYWPDKV
 | |. |.|.    . ||||. ||.|.        ||.|| .| |.||   ...|| |||.||.|.|.||...  | |||| ...|..|  ||.||.|| 
kkvnfeksRYk...niLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg

deSVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsagaADHLMVTQFHYVNWAEDEKPK--DETPLLKLIDQLLHNQMNTGNKAITVMCSDGIGRT
  ..|.|...|.| | ..|  .| |.| ......          . .| |...|.| ... ..  . . |||||... ..  .. .  . | |. |.|||
..vttfGdvsvvllsvsereGfikrelevtkgka........karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrt

GSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSFD
| .. . ||. ..| |   |.|...|  | .|| |||   ||.| . ..||.. | |
gvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1296-1581 1e-54 180.3 In-house 12-301 (301) alignment 
Range on Protein: 1296-1581
Range on HMM: 12-301/301.0
EKKSGYEKQLELINQVCRQPTEGllcdALSKTNIGKNRFPsklDTLPYDMTRVRLRTASG----TGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRM
 .. ..|.| . ....  ....      ||..|   |||    .. .||  |. |.. .     . .||||...|||... .| |.|.|||.|. |.||.
khsnkfeeqykelkegedksctv....glseenkalnrfk...nitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrl

VWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVSEEKRPHYIIRKLML--SQEST--YIN----VSAGAaDHLMVTQFHYVNWAEDEK
.|..  .||||..||.|. |. | .|||.   || ..|.. |.||.|   | ..||.| .   . |   ||.    |..   .   |.|.. ..| .|  
iwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGv

PKDETPLLKLIDQLLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSFDAYHN
 ..    |. ||. .| |   |   . | |||...|.| .. .   ||  | | | |||| .|  | ..|| |.   || . .|.| .|..  ..| |
vreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1325-1574 1.5e-54 180.0 In-house 41-278 (315) alignment 
Range on Protein: 1325-1574
Range on HMM: 41-278/315.0
SKTNIGKNRFPsklDTLPYDMTRVRL--RTASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKV
 . |  |||.    . ||.| .||.|     |   ||||| .. ....  |..|.|.| | .|.|.||||...  ..|||. ...|..|  |..||||. 
etinfkknryk...nilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrk

DESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEStyinvsagaaDHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNqMNTGNKAITVMCSDGIGRTGS
 .|| .|.. |.|.| |     ..|||.. .            ..  ||||.. .| .   .|. . ||||| ..  .  .. . .. | || |.|||| 
adsvefGsikvellsleadtdgvarklvtrkse..........esrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGv

FMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
.. . .|...|| ... |||...|  | .|| |||   .| | .|..||.. 
visidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 994-1285 5e-54 178.4 In-house 5-292 (439) alignment 
Range on Protein: 994-1285
Range on HMM: 5-292/439.0
AEFAAHTAKLHSDRDLGFEDEYKSFRNIPQGSYTTAKL---PENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTV
 ||  |  ||. ...  |......   .       | |     . .|||...| ..| .|| |  ||    | |||| .|.||  .| |||.|||  .|.
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

GDFWRMVWEFQLPTIVMLTELIERGIdkctcYWPRAlNETMdVGyDLQVTLVEQQQYVDYKLKKFLILNTSSTGGR-LDVTHYHFLAWPDHGVPADKTIM
 ||||.|.| .  ||||||.|.|        |||   .|..  | |. |    . .  .| .. | ..|   |. .   | ..|..||||. |||. . .
ddfwrlviekktvtivmltnlvesyk.....ywpsd.aevc.yg.diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashv

LAFIRRVRQTH-PPEGPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTTKRLK
| |.| .  .    |  |..|||||||||||| |.||   ..| | |. ..|   .  .|  |  |||. .|||.|..|. | |  ||...|  ..|
ldflrainsandkeeygpvvvhcsagvGrtGtiialdialeql.klenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1296-1575 4.5e-53 175.2 In-house 12-278 (281) alignment 
Range on Protein: 1296-1575
Range on HMM: 12-278/281.0
EKKSGYEKQLELINQVCRQPTEgllCDALSKTNIGKNRFpskLDTLPYDMTRVRL--RTASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVW
....|. .. | .... .. |      . .. |. |||.    .   || |||..    .. . ||||||.|.|||   ...|||.|. ..... |.|||
ndnaGfieeyeklaaigvdnta...taskadenvlknrY...snivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvw

EQWSSSIVMLCNLEENEKEVCAKYWPDKVdESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEStyinvsagaADHLMVTQFHYVNWAEDEKPKDETPLLKL
||  | |||. .  |..|  | .||||.  ....||...|| ..||....|| ||..|..||         ...  |.|..|..| .   |.. . ||. 
eqkvsaivmvtreieagklkChrYWPddn.selkygdvtvkstaeeekatyierkfkleres.........getreveqlaytaWPdhGvPattkellef

IDQLLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIE-SVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINS
 ...|. . .  . .. . || |.||||... .  ...... | . .|| . ..  | .|  .|| |||||| . ..|.... 
rkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1021-1281 7.8e-53 174.2 In-house 20-275 (283) alignment 
Range on Protein: 1021-1281
Range on HMM: 20-275/283.0
IPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDkrgsDYINASFID---GYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGID
.|. . . |   ||  |||.... ..|  |||| . .     |||||.||     ||. | ||.||.|| .|| |||.||.. .  .|||||.| |    
vpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlri

KCTCYWPRalNETMDVGyDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIR-RVRQTHPPEGpPLIVHCSAGVG
||. |||.  . ..| | .. ||| ..     .  |..|. . ||.   | ..|| .  | . |  |    .. | . .  ||. ..| |..||||.|.|
kCsqyWPk..rGsedyG.eftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkg.PivvhCstgiG

RTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDTSMTT
||..||.. .  . . . |  ..... . .||  |. .|||  ||  .|..  |   |||| .. 
rtavfiaasasvkda.ltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaa
0051429 (Phosphotyrosine protein) phosphatases II 1062-1293 1.2e-52 174.5 In-house 4-245 (272) alignment 
Range on Protein: 1062-1293
Range on HMM: 4-245/272.0
SDYINASFIDGYKR---PKAYIAAQGPLSNTVGDFWRMvWEFQLPTIVMLTELIERGIDKCTCYWP---------RALNETMDVGYDLQVTLVEQQQYVD
|.||||....|| |   |.......||| .|. ||||. .| .. |||.|... ||| .|| .|||             ...   ..| |||.. ... |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKtiMLAFIRRVRQthppeGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQeKDLN--------IY
| | ..|. ...|.|  . |.|.|...||||||| .   .|.... ...     | |..||||||..||||.. |. . ......   ..        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsle.tivddYlltnlyle

EFLANMRTMRVLMVQTEAQYVYIHDALSEYiTCGDTSMTTKRLKIVMDELTK
|... .| .|  .||||.||.....|| |.  .. .|.    |. ..|.. .
eaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaide
subfamily_PTPN23_pd Subfamily PTPN23 1292-1575 1.5e-52 173.2 In-house 8-282 (288) alignment 
Range on Protein: 1292-1575
Range on HMM: 8-282/288.0
TKVSEKKSGYEKQLELINQVCRQPTEGLLCdALSKTNIGKNRFpskLDTLPYDMTRVRLRtaSGTGDYINANHVDGYKHR-GAFLATQAPMKETVEDLWR
 |. . |.. .|. ....|   . ...  . |..|..  |||.    | |||| .|| ||  ... ||||| .| .       |.|||||...|. | |.
rkmldgktaldkkfkeleqkqdkearkrsi.aiaklyseknrs...rdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWl

MVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsagaADHLMVTQFHYVNWAEDEKPKDETPL
||.|| || |||| . || .|. ...||| . .|.|..|.. | | |... .... |.| |. ...            .|.  .. .|.|   |.    |
mvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda........davksvshlqltsWpelGvPasPetl

LKLIDQ---LLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKI-ESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINS
|...|.    .... .  .. . | || |.|||| | ..|.... ..  . ..|. | ..  | .|   ||.. |..|. ...||... 
lqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_PTPN3_pd Subfamily PTPN3 1309-1571 5.3e-52 171.5 In-house 22-273 (280) alignment 
Range on Protein: 1309-1571
Range on HMM: 22-273/280.0
NQVCRQPTEGLLCDALSKTNIGKNRFpskLDTLPYDMTRVRLRTASGtgDYINANHVD----GYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLC
.|. |.  .  .  |    |. |||.    | ||||.|||.|. ..   ||||||.|.    . .    ..||| |...|..|.|.||||| || |||| 
eqlyrkkpglaisaarkpenlsknry...rdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

NLEENEKEVCAKYWPDkVDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsagaADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLlHNQMNT
.| |. .  | .|||.  .....||.. ||. .|...  |..|.|.|....|         .. ...|. |..|.. . |.|.. .|...... ... ..
tlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdket........keerkilqlqylaWpdhgvPddsadflefverv.rklrsg

GNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILE
 .. . | || |||||| .. .   |  | ..    . . ..  |  |  |||.. ||.|  . ||.
keePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1299-1573 8.5e-52 170.8 In-house 6-266 (283) alignment 
Range on Protein: 1299-1573
Range on HMM: 6-266/283.0
SGYEKQLELINQVCRQPTEGlLCDAlSKTNIGKNRFpskLDTLPYDMTRVRLRTASGtgDYINANHVD---GYKHRGAFLATQAPMKETVEDLWRMVWEQ
.... . | .....  . .   ... .. |  |||.    . .|.|. ||.|.. |   ||||| ..     ||.   ....|.|...|| |.|.||...
nnnklfrevlkrlsvpdlda.dias.adenkrknrn...qeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

WSSSIVMLCNLEENEKEVCAKYWPDKvdESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEstyinvsAGAADHLMVTQFHYVNWAEDEKPKDETPLLKlID
  ..|||| .| |.... |..||| .   |. ||.. | |  |     .||..|.| ..       . | . |... . ...| | ..      |.| ..
kitaivmltklqedlrikCsqyWPkr..GsedyGeftvtlrkettsnsfiikelllrvn.......ssakstlllahyqvidWleygeqaiinslvk.fn

QLLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
..  .| .  .  | | || |||||. |. . . .. .. ||| |||. .|  | .|...||.  || . |...||  
kvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa
0041856 (Phosphotyrosine protein) phosphatases II 1034-1276 1e-51 170.5 In-house 1-175 (182) alignment 
Range on Protein: 1034-1276
Range on HMM: 1-175/182.0
NVSKNRFENVYSYDSSRveltaipdkrGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTeliergidkCTCYWPralnetmdv
|..|||..... || ||          ..|||||....|. ... .||.|||| .|| ||.||..| .  |||.||         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gydlqvtlveqqqyvdyklkkflilntssTGGRLDVTHYHFLAWPDHGVPAdKTIMLAFIRRVRQthppEGPPLIVHCSAGVGRTGTFITLDSMQQRldk
                             .     ...|..| |||||||    ..|.||..|..    || | .||||||||||||.. .. | ..   
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl...

qekDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGD
   .....| .. .| .|  ||.|. ||.....|| |.. ...
...gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_PTPN9_pd Subfamily PTPN9 1298-1575 1.3e-51 170.4 In-house 15-292 (297) alignment 
Range on Protein: 1298-1575
Range on HMM: 15-292/297.0
KSGYEKQLElinQVCRQPTEGLLCDALSKTNIGKNRFpskLDTLPYDMTRVRLRTASGT--GDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQ
|.|  |. .   .. ..|.|| .  . ...|. |||.    | | || ||| | . ...   ||||||.|||||.. ||.||| |.|.||.| |||||||
krGlskeya...eirnepveGtflasklranleknry...tdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeq

WSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsaGaaDHLMVTQFHYVNWAEDEKPKDETPLLKLID
    |||   ..|. .  |..|||.. ..|  .|.. |. |. |.. .| .|.| ...  |      .  ..  || | .. | .   |.. . ||....
evlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt......e..esrkvthfqflsWPdyGvPssaaslldvle

QLLHNQMN------------TGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINS
.  ..|              . .  | | || |||||| |. .   |.|.. ....||.. .|  |  |   .|   |||||.  .|||  .
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 997-1277 1.7e-50 166.4 In-house 6-298 (301) alignment 
Range on Protein: 997-1277
Range on HMM: 6-298/301.0
AAHTAKLHSDRdlgFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPD--KRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFW
 .|.|. ||..   ||..||. ..  . | |     ||   |||.|.  ||  |. |.  |.  .   .|||||.||||.. |..||||||. .|. |||
gthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfW

RMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMDVgYDLQVTLVEQQQYVDYKLKKFLI--LNTS------------STGGRLDVTHYHFLAWPDH
|..|. .  .|||.|.| |.  .||. |||.. .|. .. . ..||||..| | |. .... .   ..|            |.    ||. ..   ||..
rliwqekpvsivmvtnlkegtkskceqywpnseaeseef.gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqd

GVPADKTIMLAFIR-RVRQTHPPEGPPLIVHCSAGVGRTGTFITLDsMQQRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGDT
||  ..  .|  |   . ... ..| |..||||..|.|.|...... .     | |   ....    .|  .  .|.|  ||. |.|....|... .|
GvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvs.iglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1029-1272 4.7e-49 161.7 In-house 33-277 (287) alignment 
Range on Protein: 1029-1272
Range on HMM: 33-277/287.0
AKLPENVSKNRFENVYSYDSSRVELTAIPDkRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRAlN
|.   .|.|||. .|  .| .|| |.| ..  ||||||| .. .|.. .|.||||||.. ||.||||.|.| .  .....|  .| .  ||  |||   .
aeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.e

ETMDVGyDLQVTLVEQQ-QYVDYKLKKFLILNTSSTGGRLdVTHYHFLAWPDHGVPADKTIMLAFIRRV-----RQTHPPEGPPLIVHCSAGVGRTGTFI
  | ||    |.|.... .  .|  . . ...  .   |. |  ...|.|||....     .. |.  |      .    |  ||.||...|.||.|...
vPmrvG.GysvvlldydikePeygvralrlidletrearv.vkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGill

TLDSMQQRLDKQeKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
..  . .|| .    ...   .. .|  |  .||.  |. .. .||  | 
atlvlvsrledl.Grvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_CG7180_pd Subfamily CG7180 1007-1276 5.3e-49 161.4 In-house 15-294 (296) alignment 
Range on Protein: 1007-1276
Range on HMM: 15-294/296.0
RDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIV
  . .. |.|   .. .|   ..   ||  |||  .|  ||  || |. .  .  ||||||...|.. ..|.||  ..|  .||..|||.|.. .  ..|
frveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavv

MLTELIERGIdKCTCYWPRALnetMDVGYDLQVTLVEQQQYVDYKLKKFLILNT----------SSTGGRLdVTHYHFLAWPD-HGVPADKTIMLAFIRR
.||.  .    ..  |||      .    .. | .||..|| . | ..| .  .           ..  |. |.....  |.  . ||   . .. ..||
vLtktfdfak.mypsywpnks...keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRi.vklfqlteWeledkvPlstnalielrrr

VRQTH-----PPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDkQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCGD
||.        ||  |..|..| |..|.| ....|   . .. .|. ....|..  .|  |  .|..  .| || | |.|.. |. 
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelve.keeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_PTPN13_pd Subfamily PTPN13 1324-1574 8.2e-49 161.3 In-house 33-270 (273) alignment 
Range on Protein: 1324-1574
Range on HMM: 33-270/273.0
LSKTNIGKNRFPsklDTLPYDMTRVRLRTASGtgdYINANHVDG--YKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDK
 .| |  |||.    . |||| |||.|   .|   ||||...     |..  ..|.| |. |||.|.|.||||| .. |.|. .  |..|  | .|||..
kkkenkdknryr...nvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

VDESVTYG-KMVVKLVSEEKRPHYIIRKLMLSQESTyinvsaGAADHlmVTQFHYVNWAEDEKPKDETPLLKLIDQLLHnqMNTGNKAITVMCSDGIGRT
 .....   .. |.|.  .|.  . .|.|....  .      |.. .  |.....|.| . . |.  ..||... .. .  ..| .  | | || ||||.
knkklkvsnrlevellkvqkldgfvvralavkdses......gesre..vahlnfvkwPdhgvPssaaellqfvaevrr..lqtdagPivvhcsaGiGrs

GSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
|...... ||. |. .   || . ..  |  | |.||   || |.. .||| ..
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1297-1573 6.5e-48 158.0 In-house 4-259 (267) alignment 
Range on Protein: 1297-1573
Range on HMM: 4-259/267.0
KKSGYEKQLELINQVCRQptEGLLCDALSKTNIGKNRFPsklDTLPYDMTRVRLRTAsgTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQW
..  .||..|||...  .  .  ..  ... |  .||.    |.|||| ||| |||   . .|||| .|.||| . ||..|| |.| |. | . .. .| 
eeceiekefelikkisdt..sstisqsiaeknqernrld...dnlpyddtrvilrtk..eeeyinasyvegyktknafivtqdplkntitdfltvihdqk

SSSIVMLCNLEENEkevCAKYWPDKVDESVTYGKMVVKLVSEEKRPHYIIRKLMLsqesTYINVSAgaadHlMVTQFHYVNWAEDEKPKdetPLL-KLID
 . ||.| .  ...     ..|| |. ..  |  ..|.   |..   | |  | |     . | ||    |  || ..| .|  . . |   | |  |. 
vpvivlltkvftdn...irlfwPPkmgqakkyqdltvehslekeendyqiitlel....kfknesa....h.nvtlyyykkwnintnnk...pylkplfg

QLLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
 | .||.. ||. . | ||||.||.|.|. ..| |||.| |.|.|.|.... .|  |.|||.   .| ..|... || 
ilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
0036282 (Phosphotyrosine protein) phosphatases II 1061-1266 1.3e-47 157.0 In-house 1-164 (174) alignment 
Range on Protein: 1061-1266
Range on HMM: 1-164/174.0
GSDYINASFIDGYKRPKAYIAAQGPLSntvgdFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRalnetmdvgydlqvtlveqqqyvdyklkkflilnt
||||||||..|.. ... .|| ||||.     ||.|..|... |.|||.|..|.|. ||  |||.                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

SSTGGRLDVTHYHFLAWPDHGVPADKTiMLAFIRRVRQTHPP-EGPPLIVHCSAGVGRTGTFITLDSMQQRLDkqEKDLNIYEFLANMRTMRVLMVQTEA
 ..  .  . .|..| ||||||| . . .| |...|.. .   .| |..||||||||||||.. .. | ..|   |.  ....... .|..|  ||||. 
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtps

QYVYIHD
|| ....
Qyrflyy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1332-1575 2.2e-47 156.3 In-house 21-266 (270) alignment 
Range on Protein: 1332-1575
Range on HMM: 21-266/270.0
NRFPSKLDTLPYDMTRVRLRTAS--GTGDYINANHVDGYKHR-GAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTY
...    | ||   ||||| . .   .  |||||.| |....  ...|...|.. |... |||.||. ...|||. .|||. .. |..||| ...|.|..
kklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl

--GKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsagaADHLMvtQFHYVNWAEDEKPKDET------PLLKLIDQL--LHNQMNTGNkAITVMCSDGIG
  ||. |  .||||.  ||...| | ....          .|.   |.|..| ..  |..|        |||.. ..   ..... ..  . | ||.|.|
edgkikvlalseekeegyiltrlrleekge........errlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvg

RTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINS
||| .. .  ... .. .. .|| . |.  | .|. ||| ..|||| .  ..||.. 
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
0049772 (Phosphotyrosine protein) phosphatases II 1016-1273 2.3e-47 157.6 In-house 28-281 (314) alignment 
Range on Protein: 1016-1273
Range on HMM: 28-281/314.0
KSFRNIPQGSYTTAKLPENVSKNRFENVYSYDsSRVELtAIPDKRGSDYINASFIDGYkrpKAYIAAQGPLSNTVGDF----------WRMV--WEFQLP
 | . .| .....|.|..| .|||. ... .| .|| |    . .||||||||..||.   ...||.||||..|| ||          ||||  ..... 
rslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvr

TIVM---------------------LTELIERGidkctcywpralnetmdvG------YDLQVtlveqqqY-------VdyklkkflilntsstggRLDV
.|||                     |..| ..|                  .      ..|                 .                    .
divmsrdevladelsrLdaAlgKtpllildgng..................neptaadlellk.......eelydpelf.................erlg

THYHFLAWPDHGVPaDKTIMLAFIRRVRQThpPEGPPLIVHCSAGVGRTGTFITLDSMQQRLdkqekDLNIYEFLANMRTMRV-----LMVQTEAQYVYI
 .|. . .||...| .  ....|.. ...   ..| |..|||.||.||||||.... .  .|     .... | |. .| .|       ....  ||..|
ikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefi

HDALSEYIT
..|| ||. 
lealleylk
0043147 (Phosphotyrosine protein) phosphatases II 1061-1266 3.7e-46 152.3 In-house 4-155 (172) alignment 
Range on Protein: 1061-1266
Range on HMM: 4-155/172.0
GSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELiergidkctcywpralnetmdvgydlqvtlveqqqyvdyklkkflilNT
||||||||..|.|  |. .|| ||||.||. |||||..| .  .||.||||                                                .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................ly

SSTGGRLDVTHYHFLAWPDHGVPaDKTIMLAFIRRVRQ-THPPEGPPLIVHCSAGVGRTGTFITLDSMQqrldkqeKDLNIYEFLANMRTMRVLMVQTEA
  ..    . .|..| ||||||| .  ..| |.. ...  .  .| | .||||||||||||.. .. |.       ..|...| .| .|..|  .||.. 
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnps

QYVYIHD
|| ....
qyrflyy
0051429 (Phosphotyrosine protein) phosphatases II 1357-1576 1.1e-45 151.8 In-house 4-228 (272) alignment 
Range on Protein: 1357-1576
Range on HMM: 4-228/272.0
GDYINANHVDGYKH---RGAFLATQAPMKETVEDLWRMvWEQWSSSIVMLCNLEENEKEVCAKYWP----------DKVDESVTYGKMVVKLVSEEKRPH
..||||..|.|| .   .|.......|.. |..|.||. .|.  ..||.|...|| ... | .|||          | ......||...|.|.|||  ..
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YIIRKLMLSQESTyinvsagAADHLMVTQFHYVNWAEDEKPKDEtpLLKLIDQLLHnqmntgNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVAD---
||.|.|.|. ...       | . ..|...|| .|  .  |...  ||.|...||.      .... | || |..||| . ... .|...  | ..|   
yilrellltllls.......agearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYl

-----VFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSF
     ......  |  ||| ||.  ||.|.....||...|.
ltnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1033-1271 1.7e-44 146.6 In-house 53-282 (290) alignment 
Range on Protein: 1033-1271
Range on HMM: 53-282/290.0
ENV--SKNRFENVYSYDSSRVELTaipDKRGSDYINASFIDGYKRPkaYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNET
.|    |||. .|   | .|| |    |    ||. | ...| | .  .| .||.| .|| |.|||| . .  .|||| |||| |  ||  |.|    |.
kntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

MDVGyDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHppeGpPLIVHCSAGVGRTGTFITLDSMQQR
.  | .. |.  |...  .   || | .    .|    . |..  .|||. |.  .  .|  .| .|..    | |..||||||.||||||....   | 
ltfG.eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkas...G.pvvvhcsaGiGrtGtfvaievglqi

LdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEY
|  . |.|.. .    .|  |.  || . ||. . ..| ..
l.ldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
0046846 (Phosphotyrosine protein) phosphatases II 1056-1271 4.8e-44 145.5 In-house 6-172 (176) alignment 
Range on Protein: 1056-1271
Range on HMM: 6-172/176.0
IPDKRGSDYINASFIDGYKrpkaYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMdvgydlqvtlveqqqyvdyklkkf
. .  ..|||||..|.|..    .|| |||| .|. ||..|..| .  ..|.|||..| |  ||. |||.  .. .                        
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lilntsstggrldvtHYHFLAWPDHGVPADkTIMLAFIRRVRQTHPpEGPPLIVHCSAGVGRTGTFITLDSMQQrldkqEKDLNIYEFLANMRTMRV-LM
               .|..| ||||||| . ...| ... .|.    || | .||||||.|||||.. .. ..      ||.|...| || .| .|   .
...............qylhlpwpDhgvpdl.elllellefirealk.eggpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplga

VQTEAQYVYIHDALSEY
|||..|| ...... ..
vqtpeQyrflyefelll
0049260 (Phosphotyrosine protein) phosphatases II 1069-1266 1.5e-43 143.4 In-house 1-144 (152) alignment 
Range on Protein: 1069-1266
Range on HMM: 1-144/152.0
FIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWpralnetmdvgydlqvtlveqqqyvdyklkkflilntsstggrld
|||||..|...||.|||..||. |||||..| .  |||||||| |.| .||  |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

vtHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQqrldkqeKDLNIYEFLANMRTMRVLMVQTEAQYVYIHD
  .|..| ||||||| .  ..| ... ...    .| | .||||||||||||.. .. |        ......|..| .|..|  .|... |. ....
..qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1012-1272 1.7e-43 143.8 In-house 19-277 (307) alignment 
Range on Protein: 1012-1272
Range on HMM: 19-277/307.0
EDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAipDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTEL
 ||.. . .    . |.  .  |  |||...|   | .|. ..   |   |||| | ..    .|| .|.||||| ||. .|| |. . .. ...|| ..
vdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckv

IERGIDKCTCYWPRALNETMDV---GYDLQVTLV-EQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQthppEGPPL
|| .  ||  |||    ...     .  . |. .  ..   | .| .   |.   ...   ..|. .  |||.|||  .   . ..  ||     .  |.
ielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpv

IVHCSAGVGRTGTFITLDSMQQRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
.|||||||||.|| ...  .|... . .   .. ... ..|. |   .||||||.|.|  | || 
vvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1340-1571 2.7e-43 142.9 In-house 12-237 (237) alignment 
Range on Protein: 1340-1571
Range on HMM: 12-237/237.0
TLPYDMTRVRLRTASGTGDYINANHVDGYKHR-GAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDkVDESVTYGKMVVKLVSE
   || .|| |. | .. |||||....|.      ..|.| |.. . .|.|.|||..  | ||||  | |.... | ||||.  |.  .||.. | |  .
ivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpaaygvltvslkkk

EKRPHYIIRKLMLSQESTYInvsagaaDHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTGNKA-ITVMCSDGIGRTGSFMCMYSVLERIKIES
|.   | .| |.||.. |         .  .. |...  | .   |.  . ||..  .....     . .   . || |.|||| |. . ..| . | . 
eefsdytvrslllskrltlk.......evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekk

VADVFQYIKGARFNRPGLVQNVVQYEFCHDIILE
| |...|..    .|| ..|   || | |. |||
vvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1011-1273 8.5e-42 138.1 In-house 18-272 (288) alignment 
Range on Protein: 1011-1273
Range on HMM: 18-272/288.0
FEDEYKSFRNIPQGSY--TTAKLPENVSKNRFENVYSYDSSRVELTaipdKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVML
.|   | .|. |...   .  .  .| ...|.||..  | .|| |.         ||.|  .   | ..  | || ||  |.. .|.|. | ..  ||||
veglkkeyrdspneasidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivml

TELIERGIDKCTCYWPRALNETMDVGYDLQVTLVEQqQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPpegpPLI
.||.|.| .|   |.|  | |.. .|   .|. ... . .|  .|  |. ..  .  .  | . |.| |.|.||| .    | .. ......     |..
cellekGkeksaeyfPsklGekarigrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....Piv

VHCSAGVGRTGTFItLDSMQQRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT
||.|||||||||.| |  .  .  . . .| | ..||..|  |   .||| ||.|.|  . |.. 
vhssaGvGrtgtli.lilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_PTPN1_pd Subfamily PTPN1 1319-1573 1e-41 137.6 In-house 23-271 (290) alignment 
Range on Protein: 1319-1573
Range on HMM: 23-271/290.0
LLCDALSKTNIGKNRFpskLDTLPYDMTRVRLRTASGtgDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYW
   .|  ..| ..||.    |  ||| .|..|. |.   |||||. |.  . .  .. || |. .||. .|.||||| | ..||| .. |.|.  ||.||
ptreaklpenrnlnry...rdvspydhsrikleradn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PDKVD-ESVTYG--KMVVKLVSEEKRPHYIIRKLMLSQestyinvsAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQM-NTGNKAITVMCS
| . . .....   |. |||.|||.. .|..|.| | .          . .   ...|||. |..   |.  . .||.. .. .  . ..      . ||
Pqgeeekellledtklkvkliseerksyytvrllelen........lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

DGIGRTGSFMCMYSVLERIKIE---SVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
 ||||.|.|. . ..| .|. .   |  |. . .  .|  | ||.|   | .| .  ||| .
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1326-1574 1.6e-41 137.2 In-house 46-280 (439) alignment 
Range on Protein: 1326-1574
Range on HMM: 46-280/439.0
KTNIGKNRFPsklDTLPYDMTRVRLRTASGT--GDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKevcakYWPDkvD
. .  |||.    |  ..| ||| |.   |     |||||...||     ..|||.| |||..|.||.|.|. .. ||||.|| |  |     |||   |
eydqtknryk...dvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps..d

ESVTYGKMVVKLVSEEKRPHYIIRKLMLSQEStyinvsAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTGNKAITVMCSDGIGRTGSF
. | || ..|.   . . |.|.|| . . .|         .     | ||||. | . . | . . .|...  .   . .     . | || |.||||. 
aevcygdiavrvdrnielpnyvirgfkvfner......dttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGti

MCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
...   ||..|.|   |.   .|  | .|  .||...|| | .. .|| | 
ialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_ptpA1_pd Subfamily ptpA1 1033-1239 3.8e-41 136.2 In-house 46-264 (418) alignment 
Range on Protein: 1033-1239
Range on HMM: 46-264/418.0
ENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYkRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNE-TM
 | ||||. |.   . .||.|  | || ||||||| .|||   || .|..|||| ||. |||||||| .   ||||.   |    ||  |||  .    .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

-------DVGYDLQVTLVEQQQYVDYKLKKFLILNTSsTGGRLDVTHYHFLAWPDHGVPADKT----IMLAFIRRVRQTHPPE--GPPLIVHCSAGVGRT
       .|     | |||  |  . ..    |  |   |   |.|.|..  |||| .|        .. .   |  |  |      |.|||||||||||
siygngnevfgtysvelveviqdpereiitrnirltf.egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GTFITLDSMQQRLDKQEKDLN
||| |   | ..||.  |.|.
gtfctavimmkkldhyfkqld
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1322-1574 4.5e-41 135.5 In-house 32-278 (287) alignment 
Range on Protein: 1322-1574
Range on HMM: 32-278/287.0
DALSKTNIGKNRFPsklDTLPYDMTRVRLRTASGTG-DYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPD
 |    .. |||.    | ||.| ||| | . .  | ||||||.| .|..  ||.|.|.|.  || |.||.|.|. |.|....    |. .  | ||||.
aaeelaavkknrya...dvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPe

KVDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTyinvsagaADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQL---LHNQM-NTGNKAITVMCSDG
.       |  || |  . | |.| .| | | .  |         .  .| |.....| ..  .     |.... .    .  .   ..   . | .. |
revPmrvGGysvvlldydikePeygvralrlidlet........rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

IGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
|||.| .. .. ...| .     || . .   |  | .||| |||. .  . .  | .
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1034-1272 7.9e-41 134.6 In-house 55-289 (305) alignment 
Range on Protein: 1034-1272
Range on HMM: 55-289/305.0
NVSKNRFENVYSYDSSRVELTAIPdkrGSDYINASFIDGYKRP-KAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMD
...|||...|   | | | |   .    |||| | ..     | | .|.||||| .|. .|| || . ..  ||||   .| |  ||. ||| |  | ..
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

VGYDLQVTLVEQQQYVDYKLK-KFLILNTSS-TGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPpegpPLIVHCSAGVGRTGTFITLDSMQQR
.   . |  |   . ..   . .  .|| .   . .. | | ..  ||| |||  |   | ..  .| ..     |..||||||.||||| .... . ..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv....pivvhcsagigrtgtivaieyilek

LDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
. .. .   . |..  .|  |   .|.. ||..||  . .|.
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_PTPN14_pd Subfamily PTPN14 1287-1575 2.5e-40 133.3 In-house 8-298 (300) alignment 
Range on Protein: 1287-1575
Range on HMM: 8-298/300.0
VMDELTKVSEKKSGYEKQLELINQVCRQPTEGLLCDALSKTNIGKNRFPsklDTLPYDMTRVRLRTAS-GTGDYINANHVDGY--KHRGAFLATQAPMKE
 .|...|. |||    |     ... .. ...||  |  . |  ||||.   | |||. .||.| ..   . .|||| ..      ..  ....|.|.. 
tkdkrakilekkleegkvfteyeripkkredallstaklpenaeknrfk...dvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPlel

TVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDK--VDESVTYGKMVVKLVSEEKRPHYIIRKLMLSqestYinVSAGAADhlMVTQFHYVNWAED
||.| |.|||||  . |||| . ||. || . ||.|..    ..|..||  |     |. . .| ..| |     .  . ..      |  . |..|...
tvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklk....h..lpskeer..tvwhlqytDWpdh

EKPKDETPLLKLIDQLL--HNQMNTG------NKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
. |.| .. |. ....    ...|.       .  . | ||.|.||||  .    ... .. . . |. . ..  |  |  |||.. ||.| ......|.
gvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

NS
..
kn
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1017-1271 5.9e-40 131.7 In-house 16-268 (281) alignment 
Range on Protein: 1017-1271
Range on HMM: 16-268/281.0
SFRNIP---Q-GSYTTAKLPENVSKNRFENVYSYDSSRVELTA-IPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTEL
 | |.|        |. . | |  |||. |.   | |||.|   .|.|  .||| | .|      . || .|||  .|  |||||.|. .  .|||| ..
efsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqf

IERGIDKCTCYWPRALNETMDvgYDLqVTLVEQQQYVDYKLKkFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHppeGPPlIVHC
.|   .||. |.||     ..  .|  ...  ..  |.  |     || |  |    .||. .  |||  ||    .||  .|..|       || ..||
letnrekcaeyfprnahcclq..fdk.lsvsyedstvnkslv.ttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars...tpp.vihc

SAGVGRTGTFITLDSMQQRLDKQEKDLNIYEFLANMR-TMRVLMVQTEAQYVYIHDALSEY
||||||.||.....   | .  .    .| . .. .| | |   |||  ||. |   | ..
sagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_PTPRN_pd Subfamily PTPRN 1312-1574 7e-40 131.6 In-house 39-293 (297) alignment 
Range on Protein: 1312-1574
Range on HMM: 39-293/297.0
CRQPTEGLLCD-ALSKTNIGKNRfpsKLDTLPYDMTRVRLRT--ASGTGDYINANHVDGYK-HRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLE
|.  .|   .. | .. |. |||   . ..|||| .||.|..  .. . |||||  .      . |..|||.|. .|| |.|.||||| .  ||.|..||
cayeaepstkevakaeknvkknr...skavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrle

ENEKEVCAKYWPDKVDEsvTYGKMVVKLVSEEKR-PHYIIRKLMLSqestyiNVSAgaADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLlHNQMNTGN
|.. . |..||||.  |  .|.   |.||||      |..| . |       |. .   .   |||||.. | | . |    .||..  ..         
eegvkqckrywpdeGse..vyhiyevhlvsehiwcddylvrsfylk......nlqt..setrtvtqfhflswpeegvPasaksllefrrkv.nksyrGrs

KAITVMCSDGIGRTGSFMCMYSVLERIK-IESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
 .| | |||| |||| .. .  ||.|..      |.   ..  | .|||||.   |.||.   . | .|
cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevn
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1030-1273 7.6e-40 131.5 In-house 44-288 (305) alignment 
Range on Protein: 1030-1273
Range on HMM: 44-288/305.0
KLPENVSKNRFENVYSYDSSRVELTAipdKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNE
|  ..  |||. .|   |  || | .       .|| | ..     || .| .| || .|  ||| | .. .. .| || .|.|.|  ||. |..   ..
keaqeagknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

TMDVGYDLQVTLVEQQQYVDYKL--------KKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRqthPPEGpPLIVHCSAGVGRTGTF
...   . |   |  .  | .|.        ..  ..   . .  . |||||.  ||| ||||  . .| .. . |   |  | |..||||||.||||. 
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar...pskg.pivvhcsagigrtgsv

ITLDSMQQRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT
. |. . ..|   ..  .    |  .|  |   .||.|||...|. . .|. 
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1022-1274 5.4e-39 128.9 In-house 25-272 (285) alignment 
Range on Protein: 1022-1274
Range on HMM: 25-272/285.0
PQGSYTTAKlpENVSKNRFENVYSYDSSRVELTaipdKRGSDYINASFIDG-YKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCT
|. .||. .   |   ||. .|   . .|| |     ..  ||| ||..    |   .||..|||| .|. |||.|... ..  ..||  |.| |..||.
pnctytaye..anpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekca

CYWPRALNETMDVG-YDLQVTLVEQQQYVDYKLKKFLILNTSS-TGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGpPLIVHCSAGVGRT
 |.|  | | . .| |.. .| ....      |. . ..||   .   | . | .   |||.  | |   |. . . |..  | |  |. ||||||||||
lyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrt

GTFITLDSMQQRLDKqEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITC
 ||. .|    |. . . .... . . .||.||.  ||.  |.....  | ||.  
atfvgidyatirime.npniemldivremramrfqavqshmqflflyvvlmeyfig
0036282 (Phosphotyrosine protein) phosphatases II 1357-1567 6.3e-39 128.8 In-house 2-164 (174) alignment 
Range on Protein: 1357-1567
Range on HMM: 2-164/174.0
GDYINANHVDGYKHRGAFLATQAPMKetvedLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDkvdesvtygkmvvklvseekrphyiirklmlsqest
 |||||...|..   . ..|.|.|..      |.|..|. ....|||....|.... |  |||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

yinvsAGAADHLMVTQFHYVNWAEDEKPKDETpLLKLIDQLLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKiESVADVFQYIKGARFNRPGLV
          . .. |..|..|  .. | ... ||...... . . . ... . | || |.|||| ....| .| ... ||. |...... .|. ||| |
.....lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmv

QNVVQYEFCHD
|.  ||.|...
qtpsQyrflyy
0044763 (Phosphotyrosine protein) phosphatases II 1046-1273 6.9e-38 125.4 In-house 2-172 (178) alignment 
Range on Protein: 1046-1273
Range on HMM: 2-172/178.0
YDSSRVELTAIPDKRGSDYINASFIDGYkrpkAYIAAQGPlsntvGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNetmdvgydlqvtlveqq
.| .|| |. ...  .|||||||.|...     |.....|      |......|  . .||.||| .|.|  ||  |||.  .                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

qyvdyklkkflilntsstggrldvTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEGPPLIVHCSAGVGRTGTFITLDSMQQRldkqekDLNIYEFLA
                         .|... .||||||    ..|.|.. ... ....| | .|||||||||.||.. .. | ..      .|...| ..
........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaie

NMRTMRVlMVQTEAQYVYIHDALSEYIT
 .| .|  .|... |. ....  ...  
lvrerRp.ivpnpgqlrqLyefelrllk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1326-1571 1.2e-37 124.4 In-house 5-238 (239) alignment 
Range on Protein: 1326-1571
Range on HMM: 5-238/239.0
KTNIGKNRFPsklDTLPYDMTRVRLRTASG--TGDYINANHVDGYKH-RGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKV
. |  |||.    . . || .|| |   |     |||||...  |     |..|||  .. .  |.|||.|..    ||||  | |  |. | .||||  
rvnkaknrya...nivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

desVTYGKMVVKLVSEEKRPHYIIRKLMLSQestyinvsAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMnTGNKAITVMCSDGIGRTGS
     | .. | |   |    |||| ...||         | ..   | |.|.  | .   |.  | .| |  .. .. .  | .   . || |.||||.
...skycnlrvtlrktevfadyiirtfvmsq........vgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtga

FMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILE
|. . ..| . | .   |.|.|.|  | .|| .||   || | |  .||
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1326-1571 1.5e-37 124.0 In-house 6-239 (239) alignment 
Range on Protein: 1326-1571
Range on HMM: 6-239/239.0
KTNIGKNRFPsklDTLPYDMTRVRLRTASG--TGDYINANHVDGYKH-RGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKV
. |  |||.    . . || .|| |   |     |||||...  |     |..|||  .. .  |.|||.|..    ||||  | |  |. | .||||  
rvnkaknrya...nivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

desVTYGKMVVKLVSEEKRPHYIIRKLMLSQestyinvsAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMnTGNKAITVMCSDGIGRTGS
     | .. | |   |    |||| ...||         | ..   | |.|.  | .   |.  | .| |  .. .. .  | .   . || |.||||.
...skycnlrvtlrktevfadyiirtfvmsq........vgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtga

FMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILE
|. . ..| . | .   |.|.|.|  | .|| .||   || | |  .||
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1313-1576 1.6e-37 123.8 In-house 43-286 (290) alignment 
Range on Protein: 1313-1576
Range on HMM: 43-286/290.0
RQPTEGLLCDAlsKTNIGKNRFpskLDTLPYDMTRVRLRTaSGTGDYINANHVDGYKHrgAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKE
 |. |  . |.   |.. |||.    |    |.||| |.   . |||. ||.|.| |    |. || ..|.|| |.|||| ..  . |||||.| |. | 
vqylerkifdk..ntefkknry...kdvvcndktrvilkd.GydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGka

VCAKYWPDKVDESVTYGKMVVKLVSEEKRPHYIIRKlMLsqesTYINVSAGAADHLmvTQFHYVNWAEDEKPKDETPLLKLIDQLlhnqmNTGNKAITVM
 |..|.|.|  | .|.|.. |    |...   ||.| .|    .  .. .|    |    .. . | .   .. .  ||...  |      . .  ..| 
kceqyypekeGevltfGeitvlcseeddkdaniikk.tl....svrdkdsGkehkl..khlkikswpdksvalstlallrtlril.....rkasGpvvvh

CSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYINSF
|| ||||||.|. .   |. .      |. . ..  |  | . ||  .||    .|.|..  .|
csaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1018-1192 7.2e-37 121.8 In-house 17-189 (297) alignment 
Range on Protein: 1018-1192
Range on HMM: 17-189/297.0
FRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDkrGSDYINASFIDGY--KRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERG
...   .|...|| .  . |||. .. ..|..|| |   .   ..||||| ..     . .  || ||||||.|| |||..|.| .. .|||...| | |
ldeargesfssakrnsslrknryrdilatddtrvkllrvit..erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedG

IDKCTCYWPRALNETMDVGyDLQVTLVEQQQyVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAF
 |||. |||.. .| .  | |. |  . .    ...  ..  |.      .  |.|  ||.|||||||.|   .  |
rdkcapywpsvvqerlkag.dvvveflssts.defdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf
0041856 (Phosphotyrosine protein) phosphatases II 1328-1573 1.2e-36 121.3 In-house 1-171 (182) alignment 
Range on Protein: 1328-1573
Range on HMM: 1-171/182.0
NIGKNRFpskLDTLPYDMTRvrlrtasgTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCnleenekevCAKYWPDKVdesvt
|. |||.    | ||||..|          |||||| ..|. .   |.|||.|...||.| .||..|.  ..||.|.         .  |||...     
nldknry...sdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell.....

ygkmvvklvseekrphyiirklmlsqestyinvsagaadHLMVTQFHYVNWAEDEKPKdETPLLKLIDQLLHnqmntGNKAITVMCSDGIGRTGSFMCMY
                                       . ...|..|..|  .. |     ||..|.. |.      .... | || |.||||.. ..|
.......................................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaay

SVLERikieSvADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
 ....    .  .... .|  |  ||| |..  || |.....||..
lmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1325-1572 6.6e-36 118.5 In-house 42-235 (392) alignment 
Range on Protein: 1325-1572
Range on HMM: 42-235/392.0
SKTNIGKNRFPsklDTLPYDMTRVRL--RTASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEkevcakywpdkv
 . |. |||.    . |||| .||.|     .   ||.|| ......   |..|.|.|   ...|.||||...  ..|.|. .|.| .            
keinlkknryk...nilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

desvtygkmvvklvseekrphyiirklmlsqestyinvsaGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLlHNQMNTGNKAITVMCSDGIGRTGS
                                           |.  |.|||...| ... ||  . |||.| .. . .     . . . || |.|||| 
........................................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgv

FMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEY
 ... ||. . |   . |||...   | .|| .||   || | .  .|| 
visidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
0051082 (Phosphotyrosine protein) phosphatases II 1062-1268 1.5e-35 117.4 In-house 3-149 (151) alignment 
Range on Protein: 1062-1268
Range on HMM: 3-149/151.0
SDYINASFIDGYkrpkaYIAAQGPLSntvgDFWRMVWEFQLPTIVMLTELIERGidKCTCYWPRALnetmdvgydlqvtlveqqqyvdyklkkflilnts
|||||.|...|.     ... .|||.    ||.....| .. |||.|... |||  .|..|.|..                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

stggrLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQthpPEGPPLIVHCSAGVGRTGTFITLDSMQQRldkqekdLNIYEFLANMRTMRVLMVQTEAQY
     ..|.|...| |||.|.|    ..|.|.. ...   ... |..||||||.|||||.. |. | ..       ....| |. .| .|  .||.. |.
.....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqf

VYIHDAL
.... ||
lfqlfal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1030-1264 7.8e-35 115.1 In-house 48-273 (301) alignment 
Range on Protein: 1030-1264
Range on HMM: 48-273/301.0
KLPENvsKNRFENVYSYDSSRVELTAiPDKRGsdYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNE
 ||..  |.|...|    |. ||. .   ||    | | .|.   .|. .||.||||.||  ||| |.  ... .||||.. .|. ..||. | |   .|
ylpkd..khryptvPckPstaveviv.dGkrv..PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkise

TMDVGYdLQVTLVEQQQYVDYKLKKFLILNTSSTG--GRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPpegpPLIVHCSAGVGRTGTFITLDSM
..|.|   ......... .. |..|  .  . |||      |||| .  |.|.|||  .. .  ..  |....     |..||||||.||. .||. . .
kldigr.fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigteyl

QQRLDkQEKDLNIYEFLANMRTMRVLMVQTEAQYVYI
 ....  .. ... | |...|  |   |||. |  ..
areve.adptieltealkhlrehrwngvqtnsqlywm
0049772 (Phosphotyrosine protein) phosphatases II 1323-1576 1.9e-34 115.2 In-house 41-283 (314) alignment 
Range on Protein: 1323-1576
Range on HMM: 41-283/314.0
ALSKTNIGKNRFPsklDTLPYDmTRVRLRTASGTG-DYINANHVDGYkhrGAFLATQAPMKETVEDL----------WRMV--WEQWSSSIVM-------
|    |. |||..   | ||.| .||.| . .. | |||||..|||.    .|.|||.|...||.|.          ||||  ... .  |||       
adlflnrdknryl...dilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LCNLEENEKEVCAKYWPDKVdesvtygkmvvklvsE-------EkrphyiirklmlsqestyinvsagaadHLMVTQFHYVNWAED
              |..| .|  | .|.....                 |                                     .. .......  .
delsrLdaAlgKtpllildgngneptaadlellk...............eelydpelf...........................erlgikylripvpDg

EKPkDETPLLKLIDQLLHNqmnTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIeSVADVFQYIKGARFNRP--GLVQNVVQYEFCHDIILEYINSF
. | ..  ...... .. .     .... | |..|.||||.|.... .. . .. |......... .|. .|  |....  ||||.....|||.. .
sap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_CG42327_pd Subfamily CG42327 1015-1199 2.1e-34 113.7 In-house 8-193 (319) alignment 
Range on Protein: 1015-1199
Range on HMM: 8-193/319.0
YKSFRNIPQGSYTTAKLPENV-SKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKR-PKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELI
.. ||..||    . ..|     |.|. ||     .|| |  |.|.  . |..||.. ||.  |  ||||| .| ..  ||||.||| |  .|| ||.| 
aeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

ERGIDKCTCYWPRALNET-MDVGYDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRlDVTHYHFlAWPDHGVPADKTIMLAFIRRVRQT
| ||..|. |.|        ..  |..||| ...    | .  .|. .      | ..||| .  |.. .|||... ..| . .||..
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesr.elthywy.kwleaevPaeeaaliamllevrss
PTPc_DSPc_SM00012 1169-1269 1.8e-33 110.3 In-house 2-104 (105) alignment 
Range on Protein: 1169-1269
Range on HMM: 2-104/105.0
VTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPE--GPPLIVHCSAGVGRTGTFITLDSMQQRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHD
|.|||...||||||| . . .| ..| |.. .  .  ..|..|||||||||||||..|| . |.|.|..| ..|....  .|..|  |||||.||.....
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALS
|| 
all
0046846 (Phosphotyrosine protein) phosphatases II 1349-1574 1.7e-32 108.0 In-house 4-174 (176) alignment 
Range on Protein: 1349-1574
Range on HMM: 4-174/176.0
RLRTASGTGDYINANHVDGYKhrgaFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVtygkmvvklvseekrphyiirk
||..  .  |||||| ..|..    ..|||.|. .|..| ..|..|.  . .|.|... | ..  |. |||.  ....                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

lmlsqestyinvsagaadhlmvtQFHYVNWAEDEKPKDeTPLLKLIDQLLHNQMNtGnKAITVMCSDGIGRTGSFMCMYsvleRIKIESVADVFQYIKGA
                       |.....| .   | . . ||.|....   . . | . . | || |||||| . ..|     .. |   .|.. ..  
.......................qylhlpwpDhgvpdl.elllellefirealke.g.gpvlVHCsaGigRtgtlvaay....llelekglsveealalv

RFNRP-GLVQNVVQYEFCHDIILEYIN
|  || | ||.  ||.|... .|....
reqRplgavqtpeQyrflyefellllk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1013-1275 2.1e-32 107.1 In-house 23-279 (312) alignment 
Range on Protein: 1013-1275
Range on HMM: 23-279/312.0
DEYKSFRNIPQGSYTTAKLPeNVSKNRFENVYSYDSSRVELTAipDKrgSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELI
 |||.  || . |  || |      ||. |.  .|  |  |.   |.    || | |.    .|. ....|||| ||.  ||...  .   .|..|. ..
keykavgnivsdsectaflk.fkdlnrypniqcwdrgrftlag..de..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfv

ERGIDKCTCYWPRALN---ETMDVGYDLQVTLVEQQQYVDYKL-KKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHppegPPLI
| | .||. |    .          |  ..| .|       |. .. | .   .||    . || . .|||||.|      | ..  |.. .     |.|
edgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpvi

VHCSAGVGRTGTFITLDSMQQRLDKQEKDlNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCG
 |||||||||||.. ..||   | .  |. |. . .  .|  |   |.. .||||   .. |.. . 
ahcsagvgrtgtlaliesmiaalrhprkq.nvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
0043147 (Phosphotyrosine protein) phosphatases II 1356-1566 5.6e-32 106.2 In-house 4-154 (172) alignment 
Range on Protein: 1356-1566
Range on HMM: 4-154/172.0
TGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLeenekevcakywpdkvdesvtygkmvvklvseekrphyiirklmlsqes
  |||||...|.| .   |.|||.|. .|..| |||..|.  . ||.|..|                                                 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

tyinVSAGAADHLMVTQFHYVNWAEDEKPkDETPLLKLIDQLLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIkiesvaDVFQYIKGARFNRPGL
    .  .   . .. |..|..|     | .   ||...... . . .  .... | || |.|||| . ..| .|...      .... ..  |  ||| 
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpga

VQNVVQYEFCH
|||  || |..
vqnpsqyrfly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1328-1573 6.2e-32 105.6 In-house 33-295 (297) alignment 
Range on Protein: 1328-1573
Range on HMM: 33-295/297.0
NIGKNRFpskLDTLPYDMTRVRLRTASGTGDYINANHVD--GYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDES
 . |||.    | | .| |||.|. .    |||||..|     ..   .. .| |...||.| |..|.||    |||...|.|. .. || |||. |.| 
slrknry...rdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

VTYGKMVVKLVSEEKRPhYiiRKLMLsQESTYINVsagaADHLMVTQFHYVNWAEDEKPK---DETP--------------LLKLID--------QLLHN
 . |..||. .|.     .   ...|  | . |      ... .|.   ...| .   |    |                 .| |..        ||   
lkagdvvveflsstsde.f..drvil.telqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqlesl

QMNT-GNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
. .   |  . | || |.||.|  .    .|.... . . ||   ..  | .|. ||| . |.|...|..|. .
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1010-1284 7.4e-32 105.1 In-house 25-301 (310) alignment 
Range on Protein: 1010-1284
Range on HMM: 25-301/310.0
GFED---EYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTaIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIV
| |    .|. .    . | |     ... |||. .|   |.||| |. |   |  ||| | ..      ...| .||||  |. |||||... .  .|.
gieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil

MLTELIERGIDKCTCYWPrALNETMDVGYdLQVT-LVEQQQY-------VDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAfIRRVRQ
.|    | |  ||  ||| .|  |   |  ..|| | |  .        | .   .  . .  .    | |.  ..  ||| ||| .|   .   | . |
llckvgeegrpkcvgywp.slgvtetygc.irvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrllaq

T-HppeGpPLIVHCSAGVGRTGTFITLDSMQQRLDKQEKdLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYiTCGDTSMTTKRL
  |   | | .||||||..|... ..|.   ..||. .| ... |  ....  |.  .||| ||..|.     . . |.| .. | |
vrh...g.pcvvhcsagkdrlyvvvalklkidkldrglk.vdaeevktellksraiciqtelqyliidrvriif.argetevaekil
0049260 (Phosphotyrosine protein) phosphatases II 1365-1567 2.2e-30 100.7 In-house 2-144 (152) alignment 
Range on Protein: 1365-1567
Range on HMM: 2-144/152.0
VDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWpdkvdesvtygkmvvklvseekrphyiirklmlsqestyinvsaga
.|||..  .|.|||.|. .|..| |||..|.  . ||||..|.|. |. |..|.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

adhlmvtQFHYVNWAEDEKPKDETPLLKLIDQLLHNqMNTGNKAITVMCSDGIGRTGSFMCMYSVLerikieSVADVFQYIKGARFNRPGLVQNVVQYEF
       |.....|  .  |...  || |.. . .      .. . | || |.|||| ....| .|         .......  |  ||| |.|  |..|
.......qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrf

CHD
...
lye
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1331-1573 5.4e-30 99.4 In-house 46-271 (288) alignment 
Range on Protein: 1331-1573
Range on HMM: 46-271/288.0
KNRFPSKLDTlpyDMTRVRLRtaSGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGK
..|.         |.|||.|     .  ||.|| |   |..  .. .|||.. |.| ||.|. |.    |||||.| |  ||  |.|.| |. |.. .|.
rdryenlprc...ditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigr

MvvklVSEEKRPHYIIRKLMlsqESTYINVSAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLlhnqmNTGNKAITVMCSDGIGRTGSFMCMYSVL
.     .  |. .  | ||.   . . ...|    .. .| . |. .| .|  |..  . |.|.. |     .. .| | |..| |.|||| .. .  .|
l....ctvvkkkradidklv...kvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililial

ERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
| ....    . . ..  | .|   .|   || . | ..||..
eslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1329-1574 1.1e-29 98.1 In-house 49-288 (305) alignment 
Range on Protein: 1329-1574
Range on HMM: 49-288/305.0
IGKNRFPsklDTLPYDMTRVRLrTASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTY
 ||||.    |    |  ||.|  ..   .|| ||.|        |. ||||...|  |.| | ...   .| ||||| |   . |..|.. | .. ...
agknryk...dvgcldnnrvkl.egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

GKMVVKL-VSEEKRPHYIIRK-LMLSQESTYINVSAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQllhNQMNTGnkAITVMCSDGIGRTGSFMCM
 .   |. |  |    . .||      . | . .    .. . ||..|...| .   |  .. .|.|. .    .   |   |.| || ||||||| . .
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek...arpskg..pivvhcsagigrtgsvvml

YSVLERI----KIESVADVFQYIkgaRFNRPGLVQNVVQYEFCHDIILEYIN
  .|...    .||    ..| |   | .|   .|   || | |..||.|..
eyildqllagqiiedtdkilqki...reqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1301-1573 4.6e-29 96.4 In-house 15-277 (307) alignment 
Range on Protein: 1301-1573
Range on HMM: 15-277/307.0
YEKQLELINQVCRQPTEGLLCDALSkTNIGKNRFpskLDTLPYDMTRVRLRTASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSI
 ..  . .......  ||.  .|.| .|  |||.    |    | .|. ...   . ||| ||..    .   |...| |...|. ..| |. ..   |.
vqalvdefrvlakktpegvtveafs.antdknry...qdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVSEEkrphYIIRKlmLSQESTYINVSAG----AADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQ
.|||.. |  |  | .||| .  .  ..|.    .  ..      ..|  |. .  .|||..     | .   .... . || .   |. .   . |.. 
imlckvielakikceqywpleegqklvfgeapntisvan....lgakk..lapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea

LlhnqmNTGNKAITVMCSDGIGRTGSFMCMYSVLER-IKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
      .  .  . | || |.||.|. ...  | .. |. .   |. . ..  | .|.  .|. .|| . | ..||| 
v.....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_egg_pd Subfamily egg 1024-1269 2.8e-28 93.5 In-house 30-267 (307) alignment 
Range on Protein: 1024-1269
Range on HMM: 30-267/307.0
GSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERgiDKCTCYW
 |.|||   .|  | | . |   |||||.|     .   |.| |  ..|      .| || || ||| ||||||.. . . |||||   |   ..|  ||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyyw

PRALNETMDV-GYDLQVTLVEQQQYVD--YKLKKFLIlntssTGGRLDVTHYHFLAWpDHGVPADKTIMLAFIRRVRQTHppegPPLIVHCSAGVGRTGT
|.| .... .    |... .. ..  |  ... |. .      ||  .  .     . |    .|    |  .|..|.       | .|..  || ...|
pkaesdslvtvpGslrienlkvdskadplfrvtklkl.....vGgddeerflehwqg.dvnnssdvysplrvlrklrnls....kpvvvqdilGvskaat

FITLDSMQQ-RLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALS
.....      |        . .    .|  | | |..  .|....  . 
lvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1327-1573 2.9e-28 93.4 In-house 54-289 (305) alignment 
Range on Protein: 1327-1573
Range on HMM: 54-289/305.0
TNIGKNRFpskLDTLPYDMTRVRLRTASgTGDYINANHVDGYK-HRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDES
 .| |||.    |    |.. |.|   |   ||| ||.|         |...| |. .|....| || ..    |||||.  |  |  ||.|||    | 
iaitknry...qdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

VTY-GKMVVKLVSEEKrPhyIIRKLMLsqESTYINVSAGAADHLMVTQFHYVNWaedekPKDETPLLKLIDQLLHNQMNTGNKAITVMCSDGIGRTGSFM
..  . .||. ||  | |  . |   .  . | .|..    ... | .... .|     |    |  ||    |   .   .  | | || ||||||. .
lelksgivvenvsgsk.p..merdaei..qitllnltysgdqkmsvrhlqwtew.....pdrgvppckltslellsairgskvpivvhcsagigrtgtiv

CMYSVLERIKIE-SVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
..  .||.|  . ..  . . .|  | .|   .|| ||| | | ..|.|.
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1344-1573 4.2e-27 89.8 In-house 48-270 (285) alignment 
Range on Protein: 1344-1573
Range on HMM: 48-270/285.0
DMTRVRLRTAsgTGDYINANHVD-GYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVseEKRP
. ||| |.      ||| |. .    | . ....|| |. ||. |.|.|....  . ..||| | |   | || |.|.|. | | .||  . |   | . 
eetrvvlknh..drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlt..ecke

HYIIRKLMlsQESTYINVSAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLlhNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVF
  |   ..  .  | ||    ... | . . .   | ..  |.|  |...|   .  ...|  .| | | || |.||| .|. .     ||  .   ...
eaiagtil..naltvintedasseplymnhvqvpwwpdqlapedarpmielykwv..kkvnpkekpicvhcsagvgrtatfvgidyatirimenpnieml

QYIKGARFNRPGLVQNVVQYEFCHDIILEYI
. ..  |  |   ||. .|. | . ...||.
divremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1353-1561 6.6e-27 89.0 In-house 71-269 (301) alignment 
Range on Protein: 1353-1561
Range on HMM: 71-269/301.0
ASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVSEEkrphYIIRKLMlS
. |.   | || ..   |   |.|||.|.|.| ||.| |.       ||||..  |...|.|..| | |. |..  |.  .|....|    .|..| . |
vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknke....lilnkki.s

QESTYINVSAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDqllhnQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNR
. .  .. |.|  .   || . |..|.. . ||  . | .|..      .   .| | | ||.||||. .|.    .  ... .   .. . .|  | .|
krtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.....lvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehr

PGLVQNVVQ
   ||.. |
wngvqtnsq
0048076 (Phosphotyrosine protein) phosphatases II 1140-1271 3.2e-26 87.1 In-house 18-142 (145) alignment 
Range on Protein: 1140-1271
Range on HMM: 18-142/145.0
TLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEgPPLIVHCSAGVGRTGTFITLDSMQQrldkqeKDLN
| .. ... |....  | | .  ..    ...|..| ||||||| .  ..|.|.. ... .. .  | .||||||||||||.. .. | .      ....
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll......lgvs

IYEFLANMRTMRVLMVQTEAQYVYIHDALSEY
..| |. .|..|  .|... |. ...... |.
leealelvrsqrpgavpnpgqlrflyefelel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1320-1573 3.5e-26 86.5 In-house 28-269 (281) alignment 
Range on Protein: 1320-1573
Range on HMM: 28-269/281.0
LCDALSK-TNIGKNRFpSKLDTLpyDMTRVRLRT---ASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCA
|| .. .  |  |||. ...  |  |..||.|.       . ||| ||..     .  .. || | |||  |.|||.|.. ...|||||.. | ..| ||
lctvfnqpvnnkknry.lnipcl..disrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekca

KYWPDKVDESVTYGKMVVKLVSEekrphyIIRKLMLsqeSTYINVSAGAaDHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLlhnqmNTGNKAITVMCSD
.|.| .    . . |. |.           . | ..   .| .|.|    .  ..|.. . .| . . |.    .||.. ..      .      . || 
eyfprnahcclqfdklsvsyeds......tvnkslv...ttrlnlsyeg.etrlithwlwkewpdwqvpessevmlkilrki.....rarstppvihcsa

GIGRTGSFMCMYSVLERIKIE-SVADVFQYIKGARF-NRPGLVQNVVQYEFCHDIILEYI
|.||.|..|..   |. |.   .. |. | .   |   |   || . || .   ..|.. 
gvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
0044763 (Phosphotyrosine protein) phosphatases II 1342-1572 6.1e-26 86.5 In-house 1-170 (178) alignment 
Range on Protein: 1342-1572
Range on HMM: 1-170/178.0
PYDMTRVRLRTASG--TGDYINANHVDGYKHRGAFLAtqapmketvEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDesvtygkmvvklvsee
|.| ||| | . .|  ..|||||......  .|.. .         .| .....|.  ..||.|..  |. .. | .|||.. .                
pldrtrvllsnleglersdyinaseilpglylgslpp.........addlellkelgithivnlteelelgflkcdpywpeeag................

krphyiirklmlsqestyinvsagaadhlmvTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQmNTGNKAITVMCSDGIGRTGSFMCMYSVLERiKIeSVA
                                |......  .  |     .|.... . . . .. .... | || |.||.|.....| .... .. |. 
...............................iqylhipipDhgvpdllehflefvefieeal.dekggpvlVHCsaGvgRsgtlvaaylmkkl.gl.sle

DVFQYIKGARfnrPgLVQNVVQYEFCHDIILEY
....... .|   |  |.|  |....... |..
eaielvrerR...p.ivpnpgqlrqLyefelrl
subfamily_CG42327_pd Subfamily CG42327 1340-1496 1.3e-25 84.7 In-house 37-189 (319) alignment 
Range on Protein: 1340-1496
Range on HMM: 37-189/319.0
TLPYDMTRVRLRTA--SGTGDYINANHVDGYKH-RGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDK--VDESVTYGKMVVK
..|   ||| |.         |..|..| ||.  .  ..|.|......  |.||.|||| |  || |..| |.  .|||.|.| |   |.  .||.. | 
vvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvt

LVSEEKRPHYIIRKLMLSqestyiNVSAGAAdhLMVTQFHYvNWAEDEKPKDETPLLKLIDQ
|   | . .|.|  |.|       .|    .    .| . | .| | | | .|..|. .. .
lkgrevkdryaistlllk......rvdkees..relthywy.kwleaevPaeeaaliamlle
PTPc_DSPc_SM00012 1470-1571 1.6e-25 84.7 In-house 2-105 (105) alignment 
Range on Protein: 1470-1571
Range on HMM: 2-105/105.0
VTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTG-NKAITVMCSDGIGRTGSFMCMYSVLERIKIE-SVADVFQYIKGARFNRPGLVQNVVQYEFCHD
|...|| .| . ..|.. ...|.|.... .|. . . .| . |.||.|.|||| |.... .|.... | .  |.||..|  |  |||.||.  || |...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IILE
..||
alle
0048179 (Phosphotyrosine protein) phosphatases II 1130-1266 2.3e-25 84.4 In-house 25-139 (144) alignment 
Range on Protein: 1130-1266
Range on HMM: 25-139/144.0
TMDVGYDLQVTLVEQQQYVDYKLKkflilntsstggrldVTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPpEGPPLIVHCSAGVGRTGTFITLDSMQq
  . | .. ..|.|.  . ...                 ...|..| ||||||| . ...|.|.. ... .. || | .||||||||||||..... |  
lkklgittvinlteeyepeflere...............giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.

rldkqEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHD
     ...|...| || .|..|  .|... |. ....
.....klglsleealalvrsrrpgavpnpgqlrfLle
0051082 (Phosphotyrosine protein) phosphatases II 1358-1570 3.1e-25 83.9 In-house 4-150 (151) alignment 
Range on Protein: 1358-1570
Range on HMM: 4-150/151.0
DYINANHVDGYkhrgaFLATQAPMKetveDLWRMVWEQWSSSIVMLCNLEENEkeVCAKYWPDKVdesvtygkmvvklvseekrphyiirklmlsqesty
||||.. |.|.     ......|.     | .....|.  ..||.|...||..   |..|.|.                                     
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

invsagaadhLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHnqmnTGNKAITVMCSDGIGRTGSFMCMYSVLERikiesvADVFQYIKGARFNRPGLVQ
          . |.......| .   |     .|.....||.    ..|. . | || |.|||| ....| .|..       .... ..  |  |||.||
..........ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvq

NVVQYEFCHDIIL
   |. |..  .|
pnqqflfqlfall
subfamily_ptpA1_pd Subfamily ptpA1 1325-1527 3.5e-25 83.6 In-house 44-250 (418) alignment 
Range on Protein: 1325-1527
Range on HMM: 44-250/418.0
SKTNIGKNRFPsklDTLPYDMTRVRLRTAS--GTGDYINANHVDGYKHRgAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKV
 | |  |||.    . || . |||.|.        ||||||..||   .  |..|| |. .|. |.||||||.    ||||    || .  | .|||...
kkhntsknryt...nilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

DES--VTYGKM--VVKLVSEEkrPHYIIRKLMLSQESTYINVSAgAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQ--M---NTGNKAITVMC
       ||.   |.   | |     .|.       .  | ..    .   .||..|  | . . |    |. .|.  .   |  .   .  |  | | |
ggeqfsiygngnevfgtysve..lveviqdpereiitrnirltf.egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc

SDGIGRTGSFMCMY
| |.||||.|    
sagvgrtgtfctav
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1317-1571 7.7e-25 82.1 In-house 42-288 (310) alignment 
Range on Protein: 1317-1571
Range on HMM: 42-288/310.0
EGLLCDALsKTNIGKNRFPsklDTLPYDMTRVRLRT-ASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCA
  |  .|  | .. |||.    | .  | .||.|.   |  .||| ||.|     | .|. .| |.. |. |.|||.... . ||..||.  |. .  | 
ssltyeay.kkymhknrys...dvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcv

KYWPDkVDESVTYGKMVVKLVSEEKRpHYIIRKLMLSQESTYINVSA--GAADHLMVTQFHYVNWAEDEKPKDETpllKLIDQLLHNQMNTGNkaITVMC
 |||  .  . ||| . |  .||     . | .| ..     . |       ..| |.  .. || .   | .     . . | |  |.  |     | |
gywps.lgvtetygcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc...htvpqrllaqvrhgp..cvvhc

SDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILE
| |..|..  . .   .....     |. . .   . .|   .|. .|| . . . . 
sagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 988-1084 5.3e-24 78.2 In-house 2-95 (95) alignment 
Range on Protein: 988-1084
Range on HMM: 2-95/95.0
WEPIPVAEFAAHTAKLHSDRDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAipdKRGSDYINASFIDGYKRPKAYIAAQG
. || |. | .|  ..||. |  |..|.||       .||.     |. |||| |.. ||..|| ||.   || |||||| |.||| | ..||||||
fkpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1330-1572 1.7e-23 78.0 In-house 49-343 (350) alignment 
Range on Protein: 1330-1572
Range on HMM: 49-343/350.0
GKNRFpskLDTLPYDMTRVRLR----------TASGTGDYINANHVDGY----KHRGAF--LATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEV
 |||.    . |||. .||.|.           .  | ||||||..       .    |  .|||||...||.| .... .     |..| .. |.. | 
aknrY...knilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CAKYWPDK-VDE-SVTY---------GKMVVKLVSEEKRPH----YIIRKLMLSQESTYINVSAGAADHLMVTQFHYVNWAED---EKPKDETPLLK---
| .||..  .|.  |            . ... ... |.       |  .  | .. . ... . |.| ..| |... || .     .|..  . |.   
cyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkn

-LIDQLLHNQ-M-NTGNKAITVMCSDGIGRTGSFMCMYSVLE-----------RIKIESVAD----VFQYIKGARFNRPGLVQNVVQYEFCHDIILEY
 |||.|  .. . |   ..| | || |.|||| .. . |.|.             |..  |     ... ..  |  |  .|||. |. |... .| |
dliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1204-1272 4.2e-23 76.7 In-house 192-259 (267) alignment 
Range on Protein: 1204-1272
Range on HMM: 192-259/267.0
GPPLIVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
..||.|.||.||||.|||...||. .|. |.|  ..|..|| ..|  |. .|.|  .|.|||. |.|| 
nrPlvvacsdGvGrsGtflvidsqlera.ktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1169-1283 9.3e-23 75.2 In-house 91-205 (440) alignment 
Range on Protein: 1169-1283
Range on HMM: 91-205/440.0
VTHYHFLAWPDHGVPADKTIMLAFIRRVRQTHPPEG-PPLIVHCSAGVGRTGTFITLDSMQqRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDA
. .||. .|||.|||     .| .|. | ...   |  ||.||||||.||||  |..||.  |  |.  ...|. |. .||  |  ||||  ||...|.|
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsil.reakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea

LSEYITCGDTSMTTKR
. | . |||| .    
vlegllcgdtliledd
subfamily_egg_pd Subfamily egg 1320-1572 3.5e-22 73.5 In-house 32-269 (307) alignment 
Range on Protein: 1320-1572
Range on HMM: 32-269/307.0
LCDALSKTNIGKNRFPSkldTLPYDMTRVRLRTASG--TGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENekEVCAKY
|  |.|. |  | | .        |..||.|.   |  ..|.| ||.|.|      |. .|||.|.||.|.||||...    ||||    |.  | |  |
lttaasdnnlekarskr...vhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPDKVDESVTY--GKMVVKL--VSEEKRPHYIIRKLMLSQEStyinvsagaadhlmVTQFHYVNWAEDEKPKDE--TPLlklidQLLHNQMNTgNKAITV
||   ..|. .  | . ..   | ..  | . . || |                    . .   |  | .   .  .||     ..|    |   | . |
wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..............deerflehwqgdvnnssdvyspl.....rvlrklrnl.skpvvv

MCSDGIGRTGSFMCMYSVLERIKIES--VADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEY
 . .|. ........   |  .         | . ..  | .|.  |. |..| | . ..| .
qdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1327-1574 3.9e-22 73.0 In-house 50-286 (302) alignment 
Range on Protein: 1327-1574
Range on HMM: 50-286/302.0
TNIGKNRFPsklDTLPYDMTRVRLRTasGTGDYINANHVDGYKHRGAFLATQAPMKETV---EDLWRMVWEQWSSSIVMLCNLEENEKeVCAKYWPDKVD
 |. ||. .   |.  .| ..|.| .     .|.|| .|.  . .   . .| | ....   |. ||||...   |.|.|   || .|    ...| | .
knlkknqse...dvpildsnlvklea..epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

ESVTYGKMVVKlvsEEKRPHYIIRKlmlsQESTYINVSAGAADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNtGNKAITVMCSDGIGRTGSF
. ..|||| |      | ..    |    .. ..  .  | .. ....  .  || ... |.  . | | . .. ..... ... . ..   |.|| |.|
dykeygkmfvN...nrkVekaeeek....tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkik.adentvivSknGaGRagaf

MCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
. .  ..|... ..   . . .|  | .||  |... || . . ..| || 
ltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1006-1150 1.1e-21 72.1 In-house 3-141 (267) alignment 
Range on Protein: 1006-1150
Range on HMM: 3-141/267.0
DRDLGFEDEYKSFRNIPQGSYT-TAKLPEN-VSKNRFENVYSYDSSRVELTAIPDKrgsdYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLP
| .  .| |..  ..| . | | .  ..|.   .||....  || .|| |    .     |||||...|||. .|.|. |.||.||..||. .. . ..|
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

TIVMLTELierGIDKCTCYWPRALNETMDVgYDLQVTLVEQQQYVDY
.||.||     ..|.   .||  . ..     || |    ...  ||
vivlltkv...ftdnirlfwPPkmgqakky.qdltvehslekeendy
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1025-1273 1.7e-20 67.8 In-house 38-280 (303) alignment 
Range on Protein: 1025-1273
Range on HMM: 38-280/303.0
SYTTAKLPENVSKNRFENVYSYDSSRVELTaipDkrgSDYINASFIDGYKRPKAyIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWP
| .  .. .|. |||| .|   | |.|.|.   |   | || ||...   . || | .| ||| |  |||.|. | ..  ...|    |         .|
svsknqfvknmdknrfvdvicldhskvkls...d...ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp

RALNETMDVGYDLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVthYHFLAWPDHGVPAD-KTIMLAF---IRRVRQTHPPEGPPLIVhCSAGVGRTGT
|  .        ..|    . . .|    | | .   .    | |  .|. |||   .|.|    ..     .. | . . .  |.. .   .|.||.||
rnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhv..hhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvym.slsgcgragt

FITLDSMQQRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT
|  ... .  | ...  |..   | |.|  |.  ||  .|. ...  |.|.. 
falfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1371-1566 1.8e-20 68.0 In-house 4-197 (199) alignment 
Range on Protein: 1371-1566
Range on HMM: 4-197/199.0
RGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTYiNVSAGaadhlMV
.  ..||| |..||. |.|.||||  |  |||. . . | .   . |||     .  || . |   .   .| | |  |.|....|    |.       .
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntta.ppstr.....ei

TQFHYVNWAEDEKPKDETPLLKLI-DQLLHNQM-NTGNKAITVMCSDGIGRTGSFMCMYSVL---ERIKiESVADVFQYIKGARFNRPGLVQNVVQYEFC
... .  | |   |.    .  ..  . . ..  .  .  . | |||| | || |...   .   |  |  || |.|.  |  |  | |..  . .|.| 
shyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfi

H
.
y
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1373-1566 2.2e-20 67.7 In-house 5-196 (198) alignment 
Range on Protein: 1373-1566
Range on HMM: 5-196/198.0
AFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTYiNVSAGaadhlMVTQ
 ..||| |..||. |.|.||||  |  |||. . . | .   . |||     .  || . |   .   .| | |  |.|....|    |.       ...
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntta.ppstr.....eish

FHYVNWAEDEKPKDETPLLKLI-DQLLHNQM-NTGNKAITVMCSDGIGRTGSFMCMYSVL---ERIKiESVADVFQYIKGARFNRPGLVQNVVQYEFCH
. .  | |   |.    .  ..  . . ..  .  .  . | |||| | || |...   .   |  |  || |.|.  |  |  | |..  . .|.| .
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1453-1575 2.2e-20 67.4 In-house 73-196 (440) alignment 
Range on Protein: 1453-1575
Range on HMM: 73-196/440.0
QESTYINVSAGA-ADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFN
 .| ||| |  .  .   . |.||  | .   ||   |.||.|... ..| ..||  . | || | ||||  ... |.|   |     |.| .|.  | |
pdsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnn

RPGLVQNVVQYEFCHDIILEYINS
|| .||   || | |. .|| . .
rpqmvqtpeqyafvheavlegllc
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1033-1128 7.8e-20 65.9 In-house 46-155 (350) alignment 
Range on Protein: 1033-1128
Range on HMM: 46-155/350.0
ENVSKNRFENVYSYDSSRVELTA-------I-PDKRGSDYINASFIDGY-----KRPKA-YIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDK
|  .|||..|.  |. |||.|         .    ...|||||...          |.  |||.|.|| .|| ||.... . . . |..||...| ...|
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CTCYWPRALN
|  ||..   
cyrYWqegsy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1356-1570 8.2e-20 66.1 In-house 45-256 (290) alignment 
Range on Protein: 1356-1570
Range on HMM: 45-256/290.0
TGDYINANHVDgYKHRGAFLATQAPMKET-------VEDLWRMVWEQWSSSIVMLCNLEENEKE----VCAKYWPDKVDESVTYGKMVVKLVSEEKRPHY
. ||| ||.|  . .  ....||.| ...       .|. | |. .  . ..||||. ||....     |||| |..|.|..... . ||  | ||    
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

IIRKLMLSQEStyinvsagaADHLMVTQFHYVNWAEDEKPKDETPLLKLIDQLlhnqmNTGNKAITVMCSDGIGRTGSFMCMYSVLERIK----IESVAD
..|.|..  .            .. ||   ...| . . ..|.  ||.||...     .. . .. | | ||| |   .  .      |       ...|
etRelvvkfdd.........eeeftvtHsllkgWnklnvqedtktllsliqkv.....kasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkled

VFQYIkgaRFNRPGLVQNVVQYEFCHDIIL
| ...   | .|  ....  .. |    |.
vlkal...rkqralaitsalelafvdagiv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1076-1265 1.4e-19 65.1 In-house 4-197 (199) alignment 
Range on Protein: 1076-1265
Range on HMM: 4-197/199.0
PKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMDVGyDLQVTLVEQQQYVDYKLKKFLIL-NTSSTGGRLDVTHYHF
 . |||.| || .|. |||.||||     |||. .           ||| . . |   |  | ||        || .  ...  ||..     ...|| |
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqf

LAWPDHGVPAdKTIMLAFI---RRVRQTHPP-EGPPLIVHCSAGVGRTGTFITLDSMQ-QRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIH
 .| ..  |   .... |.   | | . .      |.||||| | | || |..||       . .   ....|    .|  |. .. .  .| .|.
tswkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1077-1265 1.7e-19 64.8 In-house 4-196 (198) alignment 
Range on Protein: 1077-1265
Range on HMM: 4-196/198.0
KAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMDVGyDLQVTLVEQQQYVDYKLKKFLIL-NTSSTGGRLDVTHYHFL
. |||.| || .|. |||.||||     |||. .           ||| . . |   |  | ||        || .  ...  ||..     ...|| | 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkyg.slsvttktittkpdytitaliltnnttappstreishyqft

AWPDHGVPAdKTIMLAFI---RRVRQTHPP-EGPPLIVHCSAGVGRTGTFITLDSMQ-QRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIH
.| ..  |   .... |.   | | . .      |.||||| | | || |..||       . .   ....|    .|  |. .. .  .| .|.
swkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1083-1264 2e-19 64.2 In-house 97-280 (302) alignment 
Range on Protein: 1083-1264
Range on HMM: 97-280/302.0
QGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMDVG-YDLQVTLVEQ--QQYVDYKLKKFLIL---NTS-STGGRLDVTHYHFL
  |  .|.  .| .. ...   .| |....| .  ||. |.   .....  | | ..   |..  ... | |  |.  .   |.   .  .  |   .| 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPDHGVPADKTIMLAFIRRVRQTHppegPPLIVHCSAGVGRTGTFITLDSMQQrLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYI
|||||| |..    |  ..            ..||||||||||||....    | | ...|  .. . .  .|. |   ||.| | .|.
awpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiq.lcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1081-1261 4.9e-19 63.4 In-house 39-210 (255) alignment 
Range on Protein: 1081-1261
Range on HMM: 39-210/255.0
AaqgplsnTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMDVgYDLQVTLVEqqQYVDYKLKKFLILNTSS-TGGRLDVTHYHFLAWPD
        ||  |....   .  ..|||... | |..||  |.|  ..| . .  |..||  .     |  |.   |. | .      .|.||..  |..
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkl.advnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWie

HGVPADKTIMLAFIRRVRQTHppegpPLIVHCSAGVGRTGTFITLDSMQQ----RLDKQE-KDLNIYEFLANMRTMRVLMVQTEAQY
.  | .   .|  .. ||...     ...||||.|.||. .|.  ... |     ||. |  .|.  ..| ..| .|   ..|  | 
knaPelareilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlql
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1366-1562 7.5e-19 62.3 In-house 84-277 (302) alignment 
Range on Protein: 1366-1562
Range on HMM: 84-277/302.0
DGYKHRGAFL-ATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVS-EEKRPHYIIRKLMLSQESTYINVSAG
|| ...         | |.|.|  | .. .   . .| ||.. |.|.. ||.|. |||.. ...|.  || || ...  ..  .| .      . |    
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

AADHLMVTQFHYVNWAEDEKPKDETPLLKLIDqllhnQMNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQY
 . .  |  ...  | .   ||.  . |...        ..  |.. | || |.||||... .   ..  . . |.|. . ..  |  | | ||.  | 
kkvkktvdilafsawpdhGapkeaytaldilk.....fcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1047-1269 3.8e-18 60.6 In-house 31-256 (290) alignment 
Range on Protein: 1047-1269
Range on HMM: 31-256/290.0
DSSRVELTAIPDKRGSDYINASFIDgYKRPKAYIAAQGPLSNT-------VGDFWRMVWEFQLPTIVMLTELIERGID----KCTCYWPRALNETMDVGy
  .|| |     .  .||| |...  .    . |. | |. ..       . .|| |. . .   .||| |  |.  .     |. | | . .| . .. 
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk.

DLQVTLVEQQQYVDYKLKKFLIlnTSSTGGRLDVTHYHFLAWPDHGVPADKTIMLAFIRRVRQthppEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQE
.|.|   .. .  | . .. ..  .   .  . |||. .  | .  |. |. ..|. |. |..    .. | ||||  |. |  .. ...   | . ...
gltvkCkskekeddvetRelvv..kfddeeeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdGiSrsAalaaiilgyQkiaets

KDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALS
..... . | ..| .| |..... .. ..  .. 
gsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1013-1273 9.1e-18 58.7 In-house 30-286 (302) alignment 
Range on Protein: 1013-1273
Range on HMM: 30-286/302.0
DEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDkrgsDYINASFIDGYKRPKAYIAAQGPLSNTV---GDFWRMVWEFQLPTIVMLT
.|.|.  ..           .|..||. |.|  .|| .| |.| ||    .|.||| ..  .  .  | || | ....    .|||||.. .  ..|.| 
kefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilv

EL--IERGIDKCTCYWPRALNETMDVGydLQVTLVEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFlaWPDHGVPADKTIMLAFIRRVRQTHPPEGPPL
    ... ...  .    . .|  ..   . .  ||...   ...   .. .  |      |.. ..  |... ||   . . . .  | . . .   ..
geeelkktlselfpkksgdykeygkmf..vNnrkVekaeeektryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakvfakkikadent

IVHCSAGVGRTGTFITLDSMQQRLDKQeKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYIT
..    |.|| |.|.||    ..|.|. |. || | ....|. |  .|..  ||| .. ||  || 
vivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyik
0048076 (Phosphotyrosine protein) phosphatases II 1417-1572 2.6e-17 58.3 In-house 2-142 (145) alignment 
Range on Protein: 1417-1572
Range on HMM: 2-142/145.0
YWPDKVDESVTYGKMVVKLVSEEKRPHYIIRKLMLSQESTYINvsagaadhLMVTQFHYVNWAEDEKPKDETPLLKLIDQLLHNQMNtGnKAITVMCSDG
|||....... .| . . |  |. . . | . | |. | ..           ...|..|..|   . | .   ||...... . . . | . . | || |
ywpseilpglylgslptaldlellkdlgittvlnltselelle........rlgiqylylpwpDhgvpdllellleflefieealke.g.gpvlVHCsaG

IGRTGSFMCMYSVLErikiESvADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEY
.||||.....| .|.    ..  .... ..  |  ||| |.|. |..|... .||.
vgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_eak_pd Subfamily eak 1027-1186 1e-16 55.3 In-house 45-198 (332) alignment 
Range on Protein: 1027-1186
Range on HMM: 45-198/332.0
TTAKLPENVSKNrFENVYSYDSSRVELTAIPDKRgSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRA
. ..  |.| .|   ..  ||   |.||.    |   ||||| ..  .  . || .  .  . |  ||.|| | . |.||.| | .| ...|   |.|  
setarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

LNETMDVGYdLQVtlvEQQQYVDYKLKKFLILNTSSTGGRLDVTHYHFLAWPDHGVPADK
  | .. |. |.|   |....|  .  ..  |  |       | ||..  | .  .|  .
treelkfGi.ldv...erkefvkrniletrllelskGnethrvlhykvfGwtettlpkye
subfamily_hpo-7_pd Subfamily hpo-7 1081-1260 1.4e-16 55.2 In-house 42-215 (263) alignment 
Range on Protein: 1081-1260
Range on HMM: 42-215/263.0
AaqgpLSNTVGDFWRMVWEFQLPTIVMLTELIERGIDKCTCYWPRALNETMDVgYDLQVTLVEQQQyvDYKLKKFLILNTSS-TGGRLDVTHYHFLAWPD
     | .|.  |....   .  ..|||..  | |..||  |.|  ..| . .  ...|.  . |.  |  ||   .|.| .      .|.|| .  |..
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkl.anvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWie

HGVPADKTIMLAFIRRVRQTHppegpPLIVHCSAGVGRTGTFITLDSMQQ----RLDKQE-KDLNIYEFLANMRTMRVLMVQTEAQ
.  | .   .|  .. .|. .     .|.||||.|.||.  |   ... |     ||. .  .|.  ..| ..| .|   ..|  |
kndpelareilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmq
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1208-1274 3.1e-16 53.5 In-house 2-67 (69) alignment 
Range on Protein: 1208-1274
Range on HMM: 2-67/69.0
IVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITC
.||||.| |||||||..     |. | || ..|.. .  ||  | .||  | .|..||||| | .  
vvhcssgtgrtgtfiaimvemari.kseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl
subfamily_hpo-7_pd Subfamily hpo-7 1382-1573 6.5e-16 53.0 In-house 44-227 (263) alignment 
Range on Protein: 1382-1573
Range on HMM: 44-227/263.0
KETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVSEEKrphyiirKLMLSQESTYINVSAgAADHLMVTQFHYVNWAED
 .|.. .....  . .. .||||. .|...| | .|.| . ||   . .. |      .       ...|  .    ...        |... |. | | 
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.......dvllktlellstlge.KkkthtvkhysykgWiek

EKPKDETPLLKLIDqllhnqMNTGNKAITVMCSDGIGRTGSFMCMYSVLE----RIKIESVA--DVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
. |..    |....      .... | . |.|| ||||. .|  . .|       ..  | .  |  . ..  | .|.. ... .|  |   ..|...
ndpelareilnilk......varnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1384-1573 7.1e-16 53.0 In-house 40-221 (255) alignment 
Range on Protein: 1384-1573
Range on HMM: 40-221/255.0
TVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKLVSeekrphyIIRKLMLSQESTYINVSAgAADHLMVTQFHYVNWAEDEK
||. .....  . .. .||||...|...| | .|.| . ||   . .. |            . . .|       ...        |. ..|  | |   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.......ssadvvlrtleitstlge.kkkthtvkhysykGWiekna

PKDETPLLKLIdqllHNQMNTgnKAITVMCSDGIGRTGSFMCMYSVLE----RIKIESVA--DVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
|..   .|...    .   ..  |.. |.|| ||||. .|. . .|       ..  . .  |  . ..  | .|.. ... .|  |.  ..|...
Pelareilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0048179 (Phosphotyrosine protein) phosphatases II 1417-1567 9.7e-16 53.3 In-house 2-139 (144) alignment 
Range on Protein: 1417-1567
Range on HMM: 2-139/144.0
YWPDKVDESVTYGKM----------------VVKLVSEEKRPHYIIRklmlsqestyinvsagaadhlmVTQFHYVNWAEDEKPKDETPLLKLIDQLLHN
..|....... .| .                |. |..|   ....                        ..|.....|   . | . . ||.... . . 
snpseilpglylgslptaldlellkklgittvinlteeyepeflere......................giqylhlpwpDhgvpdllellleflefieea

QMntGNKAITVMCSDGIGRTGSFMCMYSVLerikIESvADVFQYIKGARFNRPGLVQNVVQYEFCHD
.    .. . | || |.||||.....| ..     .   .... ..  |  ||| |.|  |..|...
le..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1208-1275 1.4e-15 51.4 In-house 1-67 (69) alignment 
Range on Protein: 1208-1275
Range on HMM: 1-67/69.0
IVHCSAGVGRTGTFITLDSMQQRLdKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCG
.||||.| |||||||..     |. | || ..|.. .  ||  | .||  | .|..||||| | .  |
vvhcssGtGrtGtfiaimvemari.kseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1347-1579 1.7e-15 51.5 In-house 57-282 (312) alignment 
Range on Protein: 1347-1579
Range on HMM: 57-282/312.0
RVRLRTASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVD-----ESVTYGKMVVKLVSEEKR
| |.  |     || || |    .   |..||.|...|.  .|...    |.||..|| . |.  | ||||  | |      .   | ... ..    | 
rgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggks

PHYIIRKLMlsqestYINVSAGAAdHLMVTQFHYVNWAEDEKPKDETPLLKLIDQllhnqMNTGNKAITVMCSDGIGRTGSFMCMYSVLER---IKIESV
   |  ...       . | |       . .. .  | .   |      |.|.       ..  .| .   || |.||||... . |..      . . |
kdkithrvl......kvvvkatgq.esklnhyqwaswpdhgmpdscdtalrllsa.....vkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnv

ADVFQYIkgaRFNRPGLVQNVVQYEFCHDIILEYINSFDAY
 |.|  .   | .|   |. . || ..  ..||.. |   |
kdsfvll...rkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1203-1272 2.2e-14 48.0 In-house 261-344 (350) alignment 
Range on Protein: 1203-1272
Range on HMM: 261-344/350.0
EGPPLIVHCSAGVGRTGTFITLDSMQQ-------------RLDKQEKDL-NIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
...|..||||||||||||..||||. .             .||.. |    |   . ..|  |. |||.  |...|..||  | 
rsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
fn3 Fibronectin type III domain 587-675 3e-14 46.1 Pfam-A 1-84 (85) alignment 
Range on Protein: 587-675
Range on HMM: 1-84/85.0
SAPSNVTLTTISSSALRLSWDNPTPYTGDITDFNYTCRGVNDTDfvpssdTQ---FgnfINGNR-VVILSNLKPFREYSCNVTAATSAGVGPP
|||.|.... ..|. |.|||. |..  |.|| .. ..| .....               . ..   |.|..||| .||...|.| . || ||.
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge......ewkeft...vprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1029-1189 5e-14 46.5 In-house 91-243 (244) alignment 
Range on Protein: 1029-1189
Range on HMM: 91-243/244.0
AKLPENVSKNRFENVYSYDSSRVELTAipDKRGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERgidkcTCYWPRAln
|  |.|  |||      .| .|| |.      |  ||||||.    |   || .| ||..|  |||.|. |  .  .|.|  . |        ||| .  
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpds..

ETMD-VGYDLQVTLVEQQQYVDYKLKKFLIlNTSSTGGRLDVTHYHFLAWPDHG-VPADKTIM
| ..    |. ||| ..... . |  .. | ..        .| .    ||  |  | |. ||
eplewyeeditvtltdrdefknikasnlei.esdmneshqaltmfqisnwpsdgttpndhfim
subfamily_eak_pd Subfamily eak 1339-1488 5.6e-14 46.3 In-house 59-199 (332) alignment 
Range on Protein: 1339-1488
Range on HMM: 59-199/332.0
DTLPYDMTRVRLRTAS-GTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKlvs
. .|||   ||| ..      ||||  ..  .    .. | .. .. |  .|.|| || | .||.| .  |.. |   ||.|||  | . .|.. |.   
kivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve...

eekRPHYiIRKLMLsqESTYINVSAGAADHlMVTQFHYVNWAEDEKPKDET
   | .. ... .|  |   . .| |   |  |  ...  |.| . || | 
...rkef.vkrnil..etrllelskGneth.rvlhykvfGwtettlpkyed
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1027-1114 1.9e-13 44.6 In-house 27-113 (332) alignment 
Range on Protein: 1027-1114
Range on HMM: 27-113/332.0
TTAKLPENVSKNRFENVYSYDSSRVELTaiPDKRGSDYINASFIDGYKRPKAYIAAQGPLSN-TVGDFWRMVWEFQLPTIVMLTELIER
|  |. .|.  ||   .| .| |||||.  |.    |. |||..||| .  ||| || |. . |   ||||| | .   |... .. |.
tydkflnnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1310-1435 2.3e-13 44.3 In-house 78-195 (244) alignment 
Range on Protein: 1310-1435
Range on HMM: 78-195/244.0
QVCRQPTEGLLCDALSKTNIGKNRFPSkldTLPYDMTRVRLRTASGTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEEN
|   .|   .. ||..  |  |||  .    ||.|. || |  .|    ||||  |        .. || |. .|  |.|.|. |.    .|.|  .||.
qniirpdpsvmkdafnpnnswknrega...glpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee

EKevcakYWPDKVDESVTYGKMVVKL
..     ||||          . | |
de.....ywpdseplewyeeditvtl
fn3 Fibronectin type III domain 882-971 2.5e-13 43.2 Pfam-A 2-85 (85) alignment 
Range on Protein: 882-971
Range on HMM: 2-85/85.0
PVRNVTFQRISPTSVNVSWMPLTleEAKGFVTGYTVTLTPSTSNNrkrqSPITMTAEPDQSYVVFTGLSAEASYSISVSGSTAAGTGESS
...|...  ...||...|| | .  . .| .|||.|.. ......     . . |...... |..||| . ..|...|   ..||.|..|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1327-1573 2.6e-13 44.3 In-house 46-279 (303) alignment 
Range on Protein: 1327-1573
Range on HMM: 46-279/303.0
TNIGKNRFpskLDTLPYDMTRVRLRTASgtgdYINANHVDGYKHRGAFLaTQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDeSV
.|. ||||    | .  | ..|.|  .|    || |....   .. | | || |.  |  |.|.|. ||    ...|    | .|      .| . |  .
knmdknrf...vdvicldhskvklsdss....yihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.fl

TYGKMVVKlVSEEKRphyiiRKLMLSQESTYINVSAGAADHLmVTQFHYVNWAEDEKPKDETP-LLKLIDQLLHNQMNTGNK-AITVMCSDGIGRTGSFM
 . . ... | | ||      .|.       . || |    . .   || .|  .. | | .| ..| | ||     .  .      |   | ||.|.| 
kfeersir.vgefkr.....velgdgwvlkvlsvsngdyksf.lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfa

CMYSVLERIKIE-SVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
 . .    .. | .  |. . ..  |  |   |||. |. . . .. |..
lfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1363-1447 4.6e-13 43.3 In-house 227-307 (440) alignment 
Range on Protein: 1363-1447
Range on HMM: 227-307/440.0
NHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLeeNEKeVCAKYWPDKVdESVTYGKMVVKLVSEEKRPHYIIR
....|| .. ||.||| |.  || |.||.| .   |.|.|| .|  |.|  |. ||| .   |||.| . |     |.     .|
qefegyskknafiatqmpldstvldfwrlvhdyristiimlnql..ndk.tcsiywpvnt.rsvtfgpftvghkgsenmnrvkvr
subfamily_CG42327_pd Subfamily CG42327 1204-1271 7.6e-13 42.8 In-house 247-314 (319) alignment 
Range on Protein: 1204-1271
Range on HMM: 247-314/319.0
GPPLIVHCSAGVGRTGTFITLDSMQQRLDKQEKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDALSEY
  ||.|||| ||||||. |. |   ..|.. .. ..| . .  .|  |   |.|  || .|.  ||||
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1328-1489 8.3e-13 42.5 In-house 34-195 (332) alignment 
Range on Protein: 1328-1489
Range on HMM: 34-195/332.0
NIGKNRFPSkldTLPYDMTRVRLRTASGTGDYINANHVDGYKHRGAFLATQAPMKETVED-LWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPDKVDESV
|.  || |       .| .|| |    |  |. ||. |||| .. |.. .|||...  |  .|||| |.  | |... ...|..|  .     |.  |  
nmdmnriph...lycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeks

TYGKMVVKLVSEEKRPHYIIRKLMLSQES--TYINVSAGAADHLMVTQFHYVNWAEDEKPKDETP
   ..  | . | .    | ||.   ..|   .  .|  |.|    |... .| .  || .|   
flhefgaksleecelkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqt
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1381-1574 4.4e-12 39.3 In-house 127-310 (346) alignment 
Range on Protein: 1381-1574
Range on HMM: 127-310/346.0
MKETVEDLWRMVWEQwSSSIVMLCNLEENEKEVCAKYWPDKVDESVTYGKMVVKlvseEKRPHYIIRklmlSQESTYINVSAGAADHLMVTQFHYVNWAE
 .  |||.| |....    .| |   ... |.  .  . |.       |||...    ..|           .| |   .  | .| ...   |.  |  
nesfvedfwymiyqe.qihlvylmvpddklkntttslfndenggyqytgkmfin....nrradvsgd....pkeytievlpegnsdsvicqvhhhapwkh

DEKPKDETPLLKLIDQLLHNQmNTGNKAITVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYIN
 ..|    |..|.| |.| .. .  |  . |.   | ||. ||.     ....      .... .|  . .||| |.   ||   . |...|| 
lqqppktlpiikmihqflsek.qvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1510-1572 6.9e-12 39.6 In-house 2-64 (69) alignment 
Range on Protein: 1510-1572
Range on HMM: 2-64/69.0
TVMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEY
 | || | ||||.|...   . ||| | . |.|  ..  |  || .| | ..| | || . | 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1071-1125 2.2e-11 37.7 In-house 230-281 (440) alignment 
Range on Protein: 1071-1125
Range on HMM: 230-281/440.0
DGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERgidKCTCYWPR
.|| . .|.||.| ||  || ||||.| .... ||.|| .| ..    |. ||| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1511-1572 3e-11 37.5 In-house 2-63 (69) alignment 
Range on Protein: 1511-1572
Range on HMM: 2-63/69.0
VMCSDGIGRTGSFMCMYSVLERIKIESVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEY
| || | ||||.|. .   . ||| | . |.|  ..  |  || .| |  .| | || . | 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
fn3 Fibronectin type III domain 788-868 3.4e-11 36.3 Pfam-A 5-84 (85) alignment 
Range on Protein: 788-868
Range on HMM: 5-84/85.0
EVTSLVLgrsNDTSFNVMWSRPATANGVIRYYTVSIRYYSNMT--TVKNATTTDTKLSINQLRPEVPYVVSVNATTNGGTGPA
 ..       ..||... || |.. .| | .|.|  |  ...   . .... | | . ...|.|  .|...| | ...|.||.
nlsvsev...tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1033-1126 1.3e-10 35.1 In-house 47-156 (349) alignment 
Range on Protein: 1033-1126
Range on HMM: 47-156/349.0
ENVSKNRFENVYSYDSSRVELTAIPDK--------------RGSDYINASFID--GYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERGI
|  .|||..... |. ||| |   .                .  ||||| ..    ..  | ||| | ||  || ||....   ... .. |..  | ..
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

DKCTCYWPRA
.||  ||   
ekcdiywqel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1204-1272 1.3e-10 35.1 In-house 265-344 (349) alignment 
Range on Protein: 1204-1272
Range on HMM: 265-344/349.0
GPPLIVHCSAGVGRTGTFITLDSMQQRLDKQEKDLN-----------IYEFLANMRTMRVLMVQTEAQYVYIHDALSEYI
 ..|.|||||| ||||...|||.. . |   ... |           |.  . ..| .|. |||  ||.. |..|| .|.
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 989-1073 2e-10 34.6 In-house 4-86 (440) alignment 
Range on Protein: 989-1073
Range on HMM: 4-86/440.0
EPIPVAEFAAHTAKlhSDRDLGFEDEYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINASFIDGY
 || ||.|| .  .  . |   ||||.  . .  .     | ||.|  |||. |. .|| ||| |  .     |||||||.|.| 
rpiivadfadyvqn..nrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1025-1111 2e-10 34.8 In-house 28-119 (347) alignment 
Range on Protein: 1025-1111
Range on HMM: 28-119/347.0
SYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRG-----SDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTEL
 .|...   ..||||  .|   |..|| |.    | .       ||||| |   .  | || .| || .|| |||.||   ..  .| . | 
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1340-1482 2.3e-10 34.9 In-house 2-125 (130) alignment 
Range on Protein: 1340-1482
Range on HMM: 2-125/130.0
TLPYDMTRVRlrtasgTGDYINANHVDGYKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKevcakYWPDKvdESVTYGKMVVKLVSEE
.|.....|..        .||||. |    .   .| ||.|. .|  |.|.|. |..   .|.|  .||...     ||||   | . . .  . . . .
alefevsrlq......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpds..ePlewyeediivtltd

KRPHYIIRKLMLSQESTYINvSagaadHLMVTQFHYVNWAEDE
.     |.   |  ||  .. |     |  .| |.  ||  | 
rdefknikasnleiesdlne.s.....hqaltmfqisnwpsdg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1356-1573 9.9e-10 32.2 In-house 89-344 (349) alignment 
Range on Protein: 1356-1573
Range on HMM: 89-344/349.0
TGDYINANHVDG--YKHRGAFLATQAPMKETVEDLWRMVWEQWSSSIVMLCNLEENEKEVCAKYWPD--------KVDESVTYGKMVV----KLVS---E
  ||||||..    ..    ..|||||.  ||.| ....  .    .. | . .|.. | | .|| .        |. .|  |   |     ..     .
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyianvqGnslrvstvkdt

EKRPHYIIRKLMLSQESTYINVSAGAADHLMVTQFHYVNWAEDEKPKDETPLLK-------LIDQLLH-NQMNTG-NKAITVMCSDGIGRTGSFMCMYSV
..  . . .   | ..    ..     .  .. |. . || .     .   .|.       |||.|   . ..|    .. | || | |||| .. . ..
dndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldll

LE--------RIKIESV---ADVFQY-IKGARFNRPGLVQNVVQYEFCHDIILEYI
|.          ||.      |. .. .   |  |  .|||. |. .... .|.|.
lsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1325-1378 1.1e-09 32.3 In-house 45-94 (95) alignment 
Range on Protein: 1325-1378
Range on HMM: 45-94/95.0
SKTNIGKNRFpskLDTLPYDMTRVRLRTASgTGDYINANHVDGYKHRGAFLATQ
|..|| ||||   |. .||| ||| | |     |||||  ||||  . ...|.|
seanipknrf...lnifpydatrvvlttkr.dsdyinacfvdgyarkncyiaaq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1197-1268 1.4e-09 32.3 In-house 222-291 (297) alignment 
Range on Protein: 1197-1268
Range on HMM: 222-291/297.0
RQTHpPEGPPLIVHCSAGVGRTGTFITLDSMQQRLDKQeKDLNIYEFLANMRTMRVLMVQTEAQYVYIHDAL
|  . |   .|.|||||||||.|  .  | . ..| |. .  ..  .|  .|  |  .|||  |. ...|| 
raem.prnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydav
subfamily_eak_pd Subfamily eak 1186-1275 2.9e-09 30.8 In-house 220-308 (332) alignment 
Range on Protein: 1186-1275
Range on HMM: 220-308/332.0
KTIMLAFIRRVRQTHPPEGPplIVHCSAGVGRTGTFITLDSMQQRLDKQEKDL-NIYEFLANMRTMRVLMVQTEAQYVYIHDALSEYITCG
.... .....   | |   |  |. .. |  |.|.|. .| . . .|.. |.|  . ...  ....|.  | .. |. .|.... .|.   
sallsstlkkyihtppsfap..iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrr
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1045-1181 4.9e-09 30.6 In-house 4-125 (130) alignment 
Range on Protein: 1045-1181
Range on HMM: 4-125/130.0
SYDSSRVEltaipdkrGSDYINASFIDGYKRPKAYIAAQGPLSNTVGDFWRMVWEFQLPTIVMLTELIERgidkcTCYWPRAlnETMD-VGYDLQVTLVE
 .. ||..        | .||||||.    | . |. .| ||..|  |||.|. |  .  .|.|  . |        ||| .  | ..    |. ||| .
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpds..ePlewyeediivtltd

QQQYVDYKLKKfLILNTSSTGGRLDVTHYHFLAWPDHG
....   | .. |  .         .| ..   ||  |
rdefknikasn.leiesdlneshqaltmfqisnwpsdg
0038934 (Phosphotyrosine protein) phosphatases II 1170-1222 7e-09 31.1 In-house 80-133 (194) alignment 
Range on Protein: 1170-1222
Range on HMM: 80-133/194.0
THYHFLAWPDHGVPADKTIMLAFIRRVRQTHPP-EGPPLIVHCSAGVGRTGTFI
 .|. | .||.|.. .  |.| |.. | . .   .|    ||| ||.|||||..
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv
fn3 Fibronectin type III domain 690-774 7.1e-08 25.7 Pfam-A 2-84 (85) alignment 
Range on Protein: 690-774
Range on HMM: 2-84/85.0
PPLNFTITPTNSSYlyLTLAWNLPSpeTANGIITSYSYVCYKG-ANN-LTFGVVDGTSVDITFTSITPFTNYSCNVSASTVAGTGPP
.| |.......|..  ||| |. |.  . .| ||.|.  . .   ..  .   |..|.   |.| ..| |.|...| | . ||.||.
aPenlsvsevtsts..ltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
PTPlike_phytase Inositol hexakisphosphate 1171-1225 6.4e-07 24.1 Pfam-A 94-145 (149) alignment 
Range on Protein: 1171-1225
Range on HMM: 94-145/149.0
HYHFLAWPDHGVPADKTIMlAFIRRVRQThpPEGPPLIVHCSAGVGRTGTFITLD
.|. .. .|.  | ....  ||.| ....  |. . |...|.|| ||| |.... 
kYvRipitdeqapeeedvD.afvrliksl..prdtalvfnCqaGrgRTTtamvia
PTPlike_phytase Inositol hexakisphosphate 1171-1225 6.4e-07 24.1 In-house 94-145 (149) alignment 
Range on Protein: 1171-1225
Range on HMM: 94-145/149.0
HYHFLAWPDHGVPADKTIMlAFIRRVRQThpPEGPPLIVHCSAGVGRTGTFITLD
.|. .. .|.  | ....  ||.| ....  |. . |...|.|| ||| |.... 
kYvRipitdeqapeeedvD.afvrliksl..prdtalvfnCqaGrgRTTtamvia
subfamily_CG42327_pd Subfamily CG42327 1508-1573 1e-06 22.6 In-house 249-315 (319) alignment 
Range on Protein: 1508-1573
Range on HMM: 249-315/319.0
AITVMCSDGIGRTGSFMCMYSVLERIKIE-SVADVFQYIKGARFNRPGLVQNVVQYEFCHDIILEYI
 ..| ||||.||||  .     .....      |. | .   | .|   |... |||| . .. || 
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
Ig_2 Immunoglobulin domain 387-469 2.2e-06 19.6 Pfam-A 11-77 (80) alignment 
Range on Protein: 387-469
Range on HMM: 11-77/80.0
VSPYNEFTLNCTVTitpspNNPQIMYLWTDGSQEVSnmQ--SGatENILNVVASVMGSftYTCNASITVNgadgtamPNDSTSVT
|.    .||.|...     .||.  . |. ...|.|  |  ..    | || |.  |.  ||| || .          . |.||.
vtegenvtLtCqap.....gnptpkvqwykdgeels..qsqna..lfipnvsaedsGt..YtCrasnseg.......skqsnsve
PTEN_1 1165-1222 4.2e-06 21.7 In-house 91-148 (196) alignment 
Range on Protein: 1165-1222
Range on HMM: 91-148/196.0
GRLDVTHYHFlAWPDHGVPADKTIMlAFIRRVRQT---HPPeGPPLIVHCSAGVGRTGTFI
 . .|...||  ..|||.|    .. ...... .    .|. |   .||| ||.||.|| .
fksgveylhf.pieDhgapslself.dicksfiewllsdpn.gnvVlVHCkaGlgRsGtvv
subfamily_CDC14_pd Subfamily CDC14 1176-1258 5e-06 20.6 In-house 240-311 (328) alignment 
Range on Protein: 1176-1258
Range on HMM: 240-311/328.0
AWPDHGVPADkTIMLAFIRRVRQThppEGpPLIVHCSAGVGRTGTFITLDSMQQrldkqeKDLNIYEFLANMRTMRVLMVQTE
 . | ..| | .|.  |.. . ..   ||  ..||| ||.|||||.|.   |..        ..  | .| .| .|  .| . 
ffiDGstPsd.aivkkfleiaeka...eG.aiavhCkaGLGrtGtLiacylmkh......yrftaaeaiawlricrPGsvigp
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1014-1124 6.7e-06 19.1 In-house 7-85 (169) alignment 
Range on Protein: 1014-1124
Range on HMM: 7-85/169.0
EYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINAsfidgykrpkayiaaqgplsntvgdfwRMVWEFQLPTIVMLTElie
| | | .. .     |.|  | .|||     .    ||.|  . .. |||||||                           ||.|| .   ||.| .   
elkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgd...

rgIDKCTCYWP
   |    .||
..tddknnfwp
subfamily_PTPDC1_pd Subfamily PTPDC1 1168-1261 6.9e-06 20.6 In-house 82-165 (182) alignment 
Range on Protein: 1168-1261
Range on HMM: 82-165/182.0
DVTHYHFlAWPDHGVPADKTiMLAFIRrVRQTHPPEGpPLIVHCSAGVGRTGTFITLDSMQQrldkqeKDLNIYEFLANMRTMRVLMVQTEAQY
....| | .|.|.||.. .. .|  .. | .    ||  . ||| || ||||  |.   . .      |.|.  . .  .|  |   .||  | 
giyvynf.gwkDygvasler.iLdivk.vvafalqeg.kvavhChaGlGrtGvliacylvya......krltaekaiklvrskrpksiqtreqv
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1014-1124 8e-06 18.8 In-house 6-84 (169) alignment 
Range on Protein: 1014-1124
Range on HMM: 6-84/169.0
EYKSFRNIPQGSYTTAKLPENVSKNRFENVYSYDSSRVELTAIPDKRGSDYINAsfidgykrpkayiaaqgplsntvgdfwRMVWEFQLPTIVMLTElie
| | | .. .     |.|  | .|||     .    ||.|  . .. |||||||                           ||.|| .   ||.| .   
elkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGd...

rgIDKCTCYWP
   |    .||
..tddknnfwp
subfamily_PTEN_pd Subfamily PTEN 1179-1265 8.5e-06 20.9 In-house 89-173 (184) alignment 
Range on Protein: 1179-1265
Range on HMM: 89-173/184.0
DHGvPADKTIMLAFIRRVRQTHPPEG-PPLIVHCSAGVGRTGTFITLDSMQQRLDKQEKdlNIYEFLANMRTMRVLMVQTEAQYVYIH
||  |.   .. .... ...    .     .||| || ||||. |.   ....| ....  .. |. |..||     |.  .|  |..
Dhn.ppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekae..ealelfaeaRtknkkgvtiPsqrRYve