Gene PTPRD-75 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP134_AA protein Get Run
AqueP134_AA_594-873 phosphatase_domain Get Run
AqueP134_AA_885-1008 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 589-911 3.8e-110 364.2 In-house 2-320 (564) alignment 
Range on Protein: 589-911
Range on HMM: 2-320/564.0
HKPIPADTLEKYVEMQHLSDNKPFNVLFSSLIRDTDHSLSVAN--ANRSKNRYKNIIPYDDNMIALQPIEGWdeFQGQYINASYINGYNFKNKFIATQGP
.|||| ..|...|.  . ...  |.  . .. . . .. ..||  ||..||||.||..|| . . |...||    .  |||||.|.||. ....||||||
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgP

LSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSpDnELQFGPFVIKVASEeEAYANFVIRSFEIlLTDGTQAKHYVKHFQFTAWPDHGVPDH
|..|. | |||.|...|..|||||.. | ..|| ..||| . . . ..| ..... .| | .|...||.|..  .  .. .. |..|.||.|||||||..
laetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleee.eeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpes

GSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQFSE
. .|. ...|| ... .  |||| |||||||||||||..|. ||..|.|...|  |.....| || .|||| .|.||.|...|| . |||| ... ....
atslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkq

IIGNFDYTDTKTKKTIYETQYQLIK
 . .   ....|. | .|. .| ..
hlqkLaeveedtemtgleleFqrLa
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 630-1009 2.4e-92 304.6 In-house 40-413 (515) alignment 
Range on Protein: 630-1009
Range on HMM: 40-413/515.0
ANANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPD
 . | .|||||||.||| . . |. |.  |. .  |.|||||....  . .||.|||. ... |.||...||.   |.|.|.  ||...|  .|||  | 
eeinfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

NELQFGPFVIKVASEeEAYANFVIRSFEILLTDGtqaKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGL
. ..|| . ... |  || .. ..| ...|  |     . |  |.|| |||.||| | | |. ....|   | ..  |.. |||||||||| .|..|  .
dsvkfGsikvelvsl.eactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvv

EQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQFSEIIGNFDYTDTKTKKTIYETQYQLIKRLTPKTTAYKCEIG--RD
 ..|  . .|  ......|..|...||| .|. |.....||..|  |||||| .|.. . ..  .     ..    ..| .| |.|   | ..  |  ||
ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrd

FIEKNRPEVPLPIDTRRVVLQQSDNDYINASYVDGYQkkKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSKACA
   |||    ||..  ||.|.  |.|||||| . | .    |. .| ||  |  ||| |... | |||.|| . |.. |.||
nhpknrygnnlplqrnrvildspdhdyinasqmkgih..ctfmttqmplpttvsdfwsmvlnnkpstivmlndksqndksca
0051299 (Phosphotyrosine protein) phosphatases II 589-872 1e-91 302.7 In-house 2-286 (288) alignment 
Range on Protein: 589-872
Range on HMM: 2-286/288.0
HKPIPADTLEKYVEMQHLSDNKPFNVLFSSLIRDT---DHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGwdEFQGQYINASYINGYNFKNKFIATQG
...|... |.|.|.. ...... .   |  |.. .   . | ..  .|..||||..|.|||.. . |....|  .  . |||||||.|||.|.|||||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqg

PLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPspDNELQFGPFVIKVASEEEaYANFVIRSFEILLTD---GTQAKHYVKHFQFTAWPDHG
||..|..| |||.|.....||||||...| .|.|.. |||.  .. |..|.....  |||. ......| .|.  .|   |.. ...|.||..|.|||||
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

VPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQV
|||. ..|. |...|....|. |||.| ||||||||||||||||. |||.. |. .|. ......| ||..|||| .|..|....||| .
vpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 590-885 1.6e-91 301.6 In-house 2-296 (305) alignment 
Range on Protein: 590-885
Range on HMM: 2-296/305.0
KPIPADTLEKYVEMQHLSDNKPFNVLFSSLIRDTD-HSLSVANANRSKNRYKNIIPYDDNMIALQPIEGWDefQGQYINASYINGYNFKNKFIATQGPLS
|.|  |.|..|.. ..  ..| ... . ||... .   .   .||..|||.|.|...||. | |.. |  |  . .||||||..||. |.|.|..|||| 
kiialddlaayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlk

STTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDNELQFGPFVIKVASEeEAYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGS
.|  | ||....|. ..|||||...||.. | . ||| |  .. .||.|.... || ........| ..|   |. . .. | ..|.| |||||||.  .
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelkse.ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

PLVIFMQKVMHYHAKLGG-PIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQFS
 |. ....|.. . |  | |.. ||||||||||.|||.|| ||..| |...|. ....|.| .|| |||| .|. |||| | | . ||.| | .  ..
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlr
subfamily_PTPRB_pd Subfamily PTPRB 589-871 7.6e-90 295.9 In-house 4-284 (293) alignment 
Range on Protein: 589-871
Range on HMM: 4-284/293.0
HKPIPADTLEKYVEMQHLSDNKPFNVLFSSL---IRDTDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKNKFIATQG
.||| ....|..|. ..  ..  |.  ...|    .|. .. . ...||.||||.||.||| . . |....  || .  ||||.||.||| ...||||||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalk..desgsDYinanyipgynsprefiatqG

PLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPsPDNELQFGPFVIKVASEEEaYANFVIRSFEILLtdgTQAKHYVKHFQFTAWPDHGVPD
|| .|. |.|||.|...|..|||||...|. .|| |||||   ... ..|   ... .||| . ..|||...|     ..... |....||.|||||||.
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa.deepvlyGdikvtlvaeee.ledwvirelkiek...ekeerkvrqyhftsWpdhgvPe

HGSPLVIFMQKVMHYH--AKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQ
. ..|. |...| ...  ..  .||| ||||||||||||||||  |.....|. .| . |. ..| .|...||| .|.||.|...|. 
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
0050432 (Phosphotyrosine protein) phosphatases II 606-877 7.9e-90 296.6 In-house 38-304 (308) alignment 
Range on Protein: 606-877
Range on HMM: 38-304/308.0
LSDNKPFNVLFSSLIR---DTDHSLSVANANRSKNRYKNIIPYDDNMIALqpiegwdEFQGQYINASYINGY--NFKNKFIATQGPLSSTTGDLWRMMWQ
. |.. ..  |  | .   . . | .   .|..|||||.|.||| . . |       .    ||||||..||  ....|||||||||..|..| |||.|.
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

ERSHVIVMLTNVIEGNRVKSEEYWPPSPD-NELQFGPFVIKVASEEEaYANFVIRSFEILLTDGTQAkHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMH
....||||||. .| .|.| ..|||.... . |..|.|.... |||. ......| .|.  ... .  ..|.||..|.|||||||.. ..|. |...| .
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrk

YHakLGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNT
..   ||||| ||||||||||||||||. |||.. |. .|. ......| ||..|||| .|..||...||| ...  |
sl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0040438 (Phosphotyrosine protein) phosphatases II 624-884 2.4e-89 295.0 In-house 34-288 (317) alignment 
Range on Protein: 624-884
Range on HMM: 34-288/317.0
DHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGwdEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEY
. | .   .|..||||..|.|||.. . |.|..|   .   ||||||..|.|.|.|||||||||..|..| |||.|.....||||||.  | .|.|...|
tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqY

WPPspDNELQFGPFVIKVASEEEaYANFVIRSFEILLTdGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFI
||   ...|..|.|.... |||| .|....| .|.  . |.. ...|.||..|.|||||||.. ..|. |...| .. .. |||.. |||||||||||||
wpl..getltygdftvtllseee.lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfi

ALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQF
|... |||.. |...|. ......| ||...||| .|..||.| ||| .....||.|. ..
aaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel
0046845 (Phosphotyrosine protein) phosphatases II 623-879 7.1e-89 293.2 In-house 18-281 (284) alignment 
Range on Protein: 623-879
Range on HMM: 18-281/284.0
TDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGWDEFqGQYINASYINGY-----NFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNR
 . | ... .|.||||||.|.|||.. . |....| .|  . ||||||..||     ..|.|||||||||..|..| |||.|.....||||||. .| .|
lslsvallpenlsknRykdilpydhsRVklksldgdled.sdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengr

VKSEEYWPPSpDNELQFGPFVIKVASEEEaYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHA--KLGGPIVTHCSAG
.| . |||.. .. |..|.| ... |||. . ....| .|.  .. |.  ..|.||..|.|||||||.. ..|. |...| ...   . ||||| |||||
ekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaG

VGRTGTFIALDIGLEQMKSEN---QIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLI
|||||||||||. |||.. |.    .|. ......|.||..||||  |..|....||| .....||.
vgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0036941 (Phosphotyrosine protein) phosphatases II 624-883 9e-88 289.7 In-house 30-288 (297) alignment 
Range on Protein: 624-883
Range on HMM: 30-288/297.0
DHSLSVANANRSKNRYKNIIPYDDNMIALqpiegwDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEY
. | .   .|..|||||.|.|||.... |      |.    ||||||..||..|.|||||||||..|..| |||.|.....||||||...| .|.| ..|
slsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WPPSPDNELQFGPFVIKVASEEEA-YANFVIRSFEILLTdGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAK--LGGPIVTHCSAGVGRTG
||.  ...|..|.|.... |.|.  ......| .|.. | |.. ...|.||..| |||||||.. ..|. |...| .....   |||.. ||||||||.|
wpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsg

TFIALDIGLEQMK---SENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQ
||||.|. |.|..    |...|. ......|.||...||| .|..||...||| .....| .|. .
tfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 592-908 1.6e-87 288.6 In-house 2-316 (318) alignment 
Range on Protein: 592-908
Range on HMM: 2-316/318.0
IPADTLEKYVEMQHLSDNKPFNVLFSSLIRDTDHSL---SVANANRSKNRYKNIIPYDDNMIALQPIEGwdEFQGQYINASYINGYNFKNKFIATQGPLS
|... ||. |.  . | .  ..  .  | |.....    |. ..|. |||| ||..||.  ..||..||  | .  ||||.||.||. |...||.|.||.
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmleg..eegsDyinanyidGyrrkkayiaaqaPlp

STTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSpdNELQFGPFVIKVASEeEAYANFVIRSFEILLtDGTQAKHYVKHFQFTAWPDHGVPDHGS
 |  |.|||.|.  | ||||||.. |  ..| . ||| .  .  ..|  |... .|   ....|.|.|..   ......  |. ...|.|||.|||..|.
etieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkee.velsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesga

PLVIFMQKVMHYHAK-LGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQFSEI
 |. ....| ....|   |||| ||||||||||.|||.|| ||..| |. .|  |...|.|.||  |||| .|..|..|.||| . .|.| .   .... 
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsr

IGNFDYTDTKTKKTIYETQYQ
| ..  .|... .|  ....|
irelreqdpesgttemdaefq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 590-908 6.5e-87 286.6 In-house 3-319 (319) alignment 
Range on Protein: 590-908
Range on HMM: 3-319/319.0
KPIPADTLEKYVEMQHLSDNKPFNVLFSSLIRDTDHS--LSVANANRSKNRYKNIIPYDDNMIALQPIEGwdEFQGQYINASYINGYNFKNKFIATQGPL
..|. . |...... . . .. ..  |  |   .. .   .  . |..||||.||..||   ..|....|    . .|||||.|.||. ..||||||.||
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqaPl

SSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPspDNELQFGPFVIKVASEEEaYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHG
. |. |.|||.|.|.|...||||.. |  .|| ..|||    |  ..| ..... .|||  ....|| ...    .      |||||.|.||||.||...
entiedfWrmvWeeessivvmltklveklkvklkkywpe..enfeeyGrlivtleeeee.ledyiirklklnkkssevetRevkhfqyteWpdhdvPeka

SPLVIFMQKVMHYHAK-LGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQFSE
  |. ..... . . |   |||| |||||||||||||.||. ||..| |. .|  ......| ||  |||. .|..|....||| | .|.| | | .. .
tslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrd

IIGNFDYTDTKTKKTIYETQYQ
 . ...  ...| .|  | ..|
rlkqlaekvadtgetglerefq
0047943 (Phosphotyrosine protein) phosphatases II 618-871 3.8e-86 284.2 In-house 24-271 (273) alignment 
Range on Protein: 618-871
Range on HMM: 24-271/273.0
SLIrDTDHSLSVANANRSKNRYKNIIPYDDNMIALqpiegwDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNR
  . . . | ..  .|..|||||.|.|||.... |      ..    ||||||..|||.|.|||||||||..|..| |||.|.....||||||...| .|
lkp.lltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgr

VKSEEYWPPSPDN-ELQFGPFVIKVASEEEaYANFVIRSFEILLTDGTQaKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAK--LGGPIVTHCSA
.| . |||.. .. .|..|.| ... |||. ......| .|.  ..  . ...|.||..| |||||||.. ..|. |...|......   .||.| ||||
ekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsa

GVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQ
||||||||||||. |.|.. |...|. ......|.||..|||| .|..||...||| 
GvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 590-872 5.6e-86 284.3 In-house 7-304 (307) alignment 
Range on Protein: 590-872
Range on HMM: 7-304/307.0
KPIPADTLEKYVEMQHLSDNKPFNVLFSSLIRDTDH-----SLSVANANRSKNRYKNIIPYDDNMIALQPIEGWDEFqGQYINASYI--------NGYNF
..|.|  |...| ...|...  .   | .|.. |..     | .   .|..|||||.|.|||.. . |....| .|  . ||||||.        .||..
lfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsled.sdYiNAsyvrvpllllldgydl

KNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSpDNELQFGPFVIKVASEEEaYANFVIRSFEILLTDGTQAKHYVKHFQFT
|.|||||||||..|  | |||.|.....||||||. .| .|.|  .||| . . ||..|.|.... |||. ......| .|.  .|||.  ..|.||..|
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhyt

AWPDHGVPDHGSPLVIFMQKVMHYHAK--LGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQ---IDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQ
.|||||||.. ..|. |...|......   |||.. ||||||||||||||... |.|...|.    .|. ......|.||...||. .|..||.. ||| 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

V
.
l
0039614 (Phosphotyrosine protein) phosphatases II 601-877 3.2e-84 278.2 In-house 23-294 (297) alignment 
Range on Protein: 601-877
Range on HMM: 23-294/297.0
VEMQHLSDNKPFNVLFSSL----IrdtDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGWDEfQGQYINASYINGYNF-KNKFIATQGPLSSTTGDLW
. . .....  .   | .|    .   | | .   .|..|||||.|.|||.... |.|..|.|.    ||||||..||.. ..|||||||||..|..| |
lllekansktllllefeellslkp...dysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetvedFw

RMMWQERSHVIVMLTNVIEGNRvKSEEYWPPSPDnelQFGPFVIKVASEEEaYANFVIRSFEILLtdgTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQ
||.|.....||||||. .| .| | ..|||.. .   ..|.|.... ..|. ......| .|.     ..  ..|.|||.| |||||||.. . |  |..
rmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslelllefle

KVMHYHAK--LGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNT
.|....|.   |||.. ||||||||||||||... |||...| ..|. ......| ||...||| .|..||.| ||| .....|
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0043336 (Phosphotyrosine protein) phosphatases II 624-870 1.3e-82 272.7 In-house 36-275 (278) alignment 
Range on Protein: 624-870
Range on HMM: 36-275/278.0
DHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGwdEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEY
. | .   .|..|||||.|.||| ... |....|  ..   ||||||..|||...|||||||||..|..| |||.|......|||||.  | .|||. .|
tysiallpenkdknrykdilpydhsrvklsllgg..dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqY

WPpspDNELQFGPFVIKVASEEEaYANFVIRSFEILLtDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFI
||   .. |..|.|.... .||. ......| .|.    |.  ...| |.....|||||||.. |.|. |...|... .. .||.. |||||||||||||
wp...ggsltygdftvtllkeeh.lddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfi

ALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
||.. |||...|  .|. ......| ||...||| .|..||.. |||
alyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPRA_pd Subfamily PTPRA 589-900 2.4e-82 271.5 In-house 11-323 (330) alignment 
Range on Protein: 589-900
Range on HMM: 11-323/330.0
HKPIPADTLEKYVEMQHLSDNKPFNVLFSSLIR---DTDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGWDefQGQYINASYINGYNFKNKFIATQG
. |.| . ||. ....   ||| |   | .|     ..   |.  . |. |||. ||.||| . . |...|| .  .  |||||.|.||. |.||||.||
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaqG

PLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPspDNELQFGPFVIKVASEEeAYANFVIRSFEIL-LTDGT--QAKHYVKHFQFTAWPDHG
|.. |  |.|||.|. .|. |||||.. | .. | . |||   .  . .|   ..|  |.    .. .| | .  |.|.|  ...  |. | ||.||| |
PkeetvedfwrmiweqksativmltelkerkeekcaqywPd..eGlvtyGnirvevedet.vlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvG

VPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVA
|| ..  .. ...|| . . . .|||| |||||||||||||.||  ||..|.|...|  ......| || .|||| .|. |.. .|||  | |.| . |.
vPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvs

QFSEIIGNFDYTDTKTKK
 . . . ..  . |.|.|
slekhlqklynkitgtdk
DSPc_SM00195 630-871 2.7e-82 271.4 In-house 23-261 (263) alignment 
Range on Protein: 630-871
Range on HMM: 23-261/263.0
ANANRSKNRYKNIIPYDDNMIALQPIEGWdeFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPD
 ..|.||||||||.|||.. . |...|.    . .||||.||.|.| |.|.|||||||.||  | |||.|.|....|||||.  | .. | ..||| . .
kkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesg

NELQFGPFVIKVASEEEAYANFVIRSFEILLTDGtQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGL
.. .|| . .|. ..|.  .....| .|.  ..  . .. |...|...||||||||. .... ....| . . .  |||| ||||||||||||...|| |
gketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

EQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQ
.....|...|. .|....|.||..|||| .|..|.....|| 
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 630-871 2.7e-82 271.4 In-house 23-261 (263) alignment 
Range on Protein: 630-871
Range on HMM: 23-261/263.0
ANANRSKNRYKNIIPYDDNMIALQPIEGWdeFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPD
 ..|.||||||||.|||.. . |...|.    . .||||.||.|.| |.|.|||||||.||  | |||.|.|....|||||.  | .. | ..||| . .
kkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesg

NELQFGPFVIKVASEEEAYANFVIRSFEILLTDGtQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGL
.. .|| . .|. ..|.  .....| .|.  ..  . .. |...|...||||||||. .... ....| . . .  |||| ||||||||||||...|| |
gketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

EQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQ
.....|...|. .|....|.||..|||| .|..|.....|| 
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPRG_pd Subfamily PTPRG 598-900 8.6e-81 266.8 In-house 7-315 (563) alignment 
Range on Protein: 598-900
Range on HMM: 7-315/563.0
EKYVEMQHLSDN----KPFN-VLFSSLIRDTDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGWDEFQgQYINASYINGYNFKNKFIATQGPLSSTTG
.|.|   | ...    . |. .   .  .| | . | .. |. |||| ||..||   . |.|. | ..    ||||.||.||. ...|||||||| .|. 
akhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgplkdtfd

DLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPspDNELQFGPFVIKVASEEEAY----ANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGS
| |||.|......|||.||. | .| | . |||   |. ...| . ..  .||        ..||. ...  .. .. .. |.....| |||||||.|  
dFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl

PLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQFSEII
| .||..|    . .  |||| |||||||||||.|.||  |.|...||...  ... ..| || ..|||..|.|||||.||| .. ..| .   |  |. 
pvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelk

GNFDYTDTKTKK
    | . . |.
nctpyleqqykn
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 589-880 1.2e-80 265.8 In-house 3-287 (315) alignment 
Range on Protein: 589-880
Range on HMM: 3-287/315.0
HKPIPADTLEKYVEMQHLSDNKPFNVLFSSLIRDTDHSLSVAN--ANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKNKFIATQGP
|.||| | |  ||  .. | .. |.  . |.     | | ||.   |. |||| |||.||   . |  .|   . . .|.||..|.||| |...||.|||
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlplle..ndphsdyvnanfidGynkkrryiaaqgp

LSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPpspDNELQFGPFVIKVASeEEAYANFVIRSFEILLTDGTQAkhyVKHFQFTAWPDHGVPDH
. .. .|.||....|    ||||||..||.. |.|.|||   |... .|.. .   | || . .. .|.. .   |  .    |  ...|.||| ||| .
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywp...dkkviyGkitvtrks.eevnteytvrtlsvvfgdnire...vvqlhytswpdmgvpky

GSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIP
  ||. ....|. .| .  |.|| |||||||||||||.||  |.|.. || ||  ..|...|..|..|||...|. |..|.||| ..||.| | 
tiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsia
Y_phosphatase Protein-tyrosine phosphatase 633-870 2.9e-80 264.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 633-870
Range on HMM: 1-235/235.0
NRSKNRYKNIIPYDDNMIALqpiegwD------EfqgqYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPP
|..|||||.|.|||.... |      .      .    ||||.|..||. |.|||||||||.|| .| |||.|||...||||||.. | .|.| ..||| 
nkkknRykdilpydktrvkl......kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpe

SPDNELQFGPFVIKVA-SEEEAYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIAL
. ...|..| . ...  .|.|. .....| .|.  ... ..|. ||....|.|||||||.. ..|. ...|| .....  ||.| ||||||||||||.||
eeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

DIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
|| |||...|...|  ||....| ||..|||...|.|||....||
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 633-870 2.9e-80 264.4 In-house 1-235 (235) alignment 
Range on Protein: 633-870
Range on HMM: 1-235/235.0
NRSKNRYKNIIPYDDNMIALqpiegwD------EfqgqYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPP
|..|||||.|.|||.... |      .      .    ||||.|..||. |.|||||||||.|| .| |||.|||...||||||.. | .|.| ..||| 
nkkknRykdilpydktrvkl......kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpe

SPDNELQFGPFVIKVA-SEEEAYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIAL
. ...|..| . ...  .|.|. .....| .|.  ... ..|. ||....|.|||||||.. ..|. ...|| .....  ||.| ||||||||||||.||
eeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

DIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
|| |||...|...|  ||....| ||..|||...|.|||....||
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0040439 (Phosphotyrosine protein) phosphatases II 627-872 1.1e-79 262.9 In-house 5-246 (249) alignment 
Range on Protein: 627-872
Range on HMM: 5-246/249.0
LSVANANRSKNRYKNIIPYDDNMIALQPIEGwdEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPP
 .   .|..||||..|.||| ... |....|   | . |||||||.||..|..||||||||..|..| |||.|.....||||||.  | .|.| ..|||.
vallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

spDNELQFGPFVIKVASEEEaYANFVIRSFEILLTdGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAK--LGGPIVTHCSAGVGRTGTFIA
  ...|..| |.... |.|. ......| .|.  . ... ...|.|.|.| |||||||.. ..|. |...|......   |||.. ||||||||||||||
..ggsleygdftvtllsvev.kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

LDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQV
... |||.. |...|. ......|.||...||. .|..||.. ||| .
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPRK_pd Subfamily PTPRK 607-900 3.4e-79 260.9 In-house 19-305 (314) alignment 
Range on Protein: 607-900
Range on HMM: 19-305/314.0
SDNKPFNVLFSSLIRDTDHslSVANANRSKNRYKNIIPYDDNMIALQPIEGwdEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVI
...  |.  . ||.   |   .  . ||.|||...|..||  .. |..|.|  . . .||||..|..|.  ..||.||||| .|. |.||....|..  |
aegygfkeeyeslfegwda..akkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasi

VMLTNVIEGNRVKSEEYWPpspDNELQFGPFVIKVASEeEAYANFVIRSFEILL-TDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLG
||||...|  |||  .|||   ..  ..|.. ... .  |. |..|.| | .   . | .... |..|||..||||.|| .   |. ....| . ...  
vmltelvevgrvkClkyWP...edtevygdikvelvet.ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeea

GPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQFSEIIGNFDYTDTKTKK
|.|| ||||| ||||||||.|| |. .. |. .|  ... ..|.... ||.| .|..|..| .|| .|||.| |||..|  .  .    |..|. 
GrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtns
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 610-870 6.5e-79 260.0 In-house 25-277 (288) alignment 
Range on Protein: 610-870
Range on HMM: 25-277/288.0
KPFNVLfSSLIRDTDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVML
. .|.| ..| .. ... .    | .||||.||.||| . . |.  |  .| .  |||||||.|.. |.|.||||||| .| .| |......... ||||
eeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkle..eeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml

TNVIEGNRVKSEEYWPpSPDNELQFGPFVIKVASEEEaYANFVIRSFEILltdGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIV
|...||.. | ||||| . |.. ..| . ... ...|   .|| |....     .. .  ....|..||||||||.   ||. ....|   . .  |||.
telveggktkCeeYWP.dadkpknyGsvtvtlveske.ledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpii

THCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
 ||||||||||||||||  ......|..|| . .....| ||. .||| .|..|....||.
vhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 590-885 3.3e-77 254.9 In-house 14-304 (319) alignment 
Range on Protein: 590-885
Range on HMM: 14-304/319.0
KPIPADTLEKYVEMQHLSDNKPFNVLFSSLI----RDTDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGwDEFqGQYINASYINGYNFKNKFIATQG
...||  ... .  .   | . ..| |  .       .| . .  . |. |||. ||...| |.. |....|  ||   |||||...||  |.|.||.||
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliG.eef.sdyinasfvtGyqrkdkyiaaqG

PLSSTTGDLWRMMWQERSHVIVMLTnviegnRVKSEEYWPPSPDneLQFGPFVIKVASEEEAyANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPD
||  |  |.|||.|. ..  ||.||      . |  .|||   .   . . | .|| | ||. |..|.|..|.      . .  .. | |  |||.||||
PldntladfWrmiweyncstivllt......kdkcsqywplkiv..ikeerfkvkvdsveet.aeyvvrdielsedgkekdirkitqfhflGwpdvGvpd

HGSPLVIFMQKVMHYHAKLGG--PIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQ
..|.|. ...|| | . |  .  .|| ||||||||||..|.||. |..|| |.|.|  ......|.|| ..|| . |. |.. .|||. | |.. . . .
ypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampd

FS
| 
fp
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 592-872 3.4e-77 254.2 In-house 2-283 (290) alignment 
Range on Protein: 592-872
Range on HMM: 2-283/290.0
IPADTLEKYVEMQHLSDNKPFNVLFSSLIR-DTDHSL--SVANANRSKNRYKNIIPYDDNMIALQPIEGWDEFQGQYINASYINGYNFKNKFIATQGPLS
|| | . ..|. .|   |. |.  | .|   . .|.    ... |. .||..||..|||| | |.|| |  . . .||||.||.||. |...||||||.|
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

STTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSpDNELqFGPFVIKVASEEEAYaNFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHG-VPDHG
.|  | |...|||.. .||||||.|| ..||   ||| | |..  .|.| ||. .||.   ....| .|.  .. ..||. |...|.|.|...| |... 
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpq

SPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQV
. |... . .   . .  ..|| |||..|||...|.|........|.| .|| .|.....| |.. .||| .|. .... .|. .
tillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 615-879 3.8e-77 254.5 In-house 32-297 (298) alignment 
Range on Protein: 615-879
Range on HMM: 32-297/298.0
LFS------SLIRDTDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVM
 |       | |... .. . ...|..|||| .||..|   . |. ..  .. ...|||||....|. .| |||||.|| .|. | |||...| . .|||
efqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVm

LTNVIEGNRVKSEEYWPPSpdNELQFGPFVIKVASEEeAYANFVIRSFEILLTDgTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLG-GP
|||. | ...| ..||| .  .. ..| . ... |.|  .|....| ...  .. .. .. |....|| |||.||| . . .. ...||  .. . |  |
ltnleeldktkyhkywPde..gketygeitvsllske.efadlivrklkvskkk.eekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkp

IVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLI
.. .|||||||.|||||.|  ||..| |. .|  |... .| .|...||| .|..|...  || . ..|. |
vivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0045098 (Phosphotyrosine protein) phosphatases II 630-875 7.4e-77 253.7 In-house 30-275 (278) alignment 
Range on Protein: 630-875
Range on HMM: 30-275/278.0
ANANRSKNRYKNIIPYDDNMIAlqpiegwdefqgQYINASYINGYnfKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPspD
   |..|||||.|.||| ...              |||||||.||  ..||||||||| ||. | |||.|.....||||||...|..|.| ..|||.  .
ylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..g

NELQFGPFVIKVASEEEAyANFVIRSFEILLT---DGTQAKHYVKHFQFTAWPDHGVPDHG--SPLVIFMQKVMHYHAK-------------LGGPIVTH
. |..|.|.... |||.   ....| ...  .   . .  ...|.|.... |||||||..   ...  ... . .....              |||.. |
gsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CSAGVGRTGTFIALDIGLEQMksENQIDFIQIINQMRDQRMH-MVQTINQFIFLHDTLLEQVLCG
||||||||||..|... ||..  |...|. ......| ||.. .||. .|..||.. ||| .|.|
CsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0042113 (Phosphotyrosine protein) phosphatases II 630-870 9.4e-77 253.0 In-house 6-241 (245) alignment 
Range on Protein: 630-870
Range on HMM: 6-241/245.0
ANANRSKNRYKNIIPYDDNMIALQPIEGwdEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPspD
  .|..||||..|.|||.... |.|..|  ..   ||||||..||....|||||||||..|..| |||.|......|||||.  | .|||...|||.  .
lpenkdknrysdilpydhtrvklspdgg..dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

NELQFGPFVIKVASEEEaYANFVIRSFEILLTdGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHA-KLGGPIVTHCSAGVGRTGTFIALDIG
..|..| |.... |||  ......| .|.  . |.  .. | |.... ||||||||. . |. |.. | .. | . .||.. ||||||||||||||... 
esltygdftvtllseeh.lddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
|||...|  ... ... ..|.||...||| .|..||.. |||
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 592-877 4.8e-76 250.5 In-house 2-283 (287) alignment 
Range on Protein: 592-877
Range on HMM: 2-283/287.0
IPADTLEKYVEMQHLSDNKPFNVLFSSLIR--DTDH--SLSVANANRSKNRYKNIIPYDDNMIALQpiegwdEFQGQYINASYINGYNFKNKFIATQGPL
|| . . ..|. .|   |. |.  |  | .  ....    ..|. |. |||...|...|.. . |.      . . .||||..|.||. |..||....|.
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesPm

SSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDneLQFGPFVIKVASEEeAYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHG-VPDH
..|  ..|....... ..||||..  | .. .  .||| .    . .|.. |.. .||  .|....| .|.  .. ...|. || .|.|.|...| |...
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtep

GSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNT
 . |... ...   . .  ..|| |||..|||...|.| ...... | |  || .|.....| |....|||..|..|. | .||.. ...|
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 622-885 9.4e-76 250.0 In-house 14-268 (284) alignment 
Range on Protein: 622-885
Range on HMM: 14-268/284.0
DTDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGwDEFqGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTnviegnRVKSE
 || . .  . |. |||. .|...| |.. |... |  ||   |||||.|.||  |.|.|||||||  |  |.|||.|. ..  ||.||      . |  
gtdqtfanldqnkdknrighilafdknvvklerliG.eef.sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcs

EYWPPSPDneLQFGPFVIKVASEEEAyANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGG--PIVTHCSAGVGRT
.|||   .   . . | .|| | ||. ...|.|..|.      . .  .. | |  |||.||||..|.|. ...|| | . |  .  .|| |||||||||
qywplkiv..ikeerfkvkvdsvees.eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQFS
|..|.||. |..|| |.|.|  ......|.|| ..|| . |. |.. .|||. | |.. . ...| 
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfp
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 600-871 3.8e-74 244.3 In-house 5-275 (281) alignment 
Range on Protein: 600-871
Range on HMM: 5-275/281.0
YVEMQHLSDNKPFNVLFSSLIR-DTD--HSLSVANANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWR
 .. .. .||. |   ...|   ..|   . | |..|. ||||.||. ||   . ..| |  .. .  ||||....||. ....||||||. ..  . |.
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpne..enkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MMWQERSHVIVMLTNVIEGNRVKSEEYWPpSPDNELQFGPFVIKVASEEEaYANFVIRSFEIlLTDGTQaKHYVKHFQFTAWPDHGVPDHGSPLVIFMQK
|.|... ..|||.|. ||....|   |||  ...||..| ...|  .|||  |... | |..  ..... .  |.....|||||||||.  . |. | ..
mvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeee.katyierkfkl.eresge.treveqlaytaWPdhGvPattkellefrke

VMHYHAKLG-GPIVTHCSAGVGRTGTFIALDIGLEQMKSE-NQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQ
|.... |    |.| |||||||||||.||||  ......| ...|  ......| .|. ||||. |. |.. ..|. 
vlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Ptp69D_pd Subfamily Ptp69D 591-888 7.1e-74 243.7 In-house 3-302 (307) alignment 
Range on Protein: 591-888
Range on HMM: 3-302/307.0
PIPADTLEKYVEMQHLSDNKPFNVLFSSLI-RDTDHS--LSVANANRSKNRYKNIIPYDDNMIALQPIEGWDefQGQYINASYINGYNFKNKFIATQGPL
.|. |.||. .. ..   .  .   . .|  | .|.|   |  . |  ||||..|...|.. . |..|.| .  . .|||||.|.||. |.|||| |.|.
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPv

SSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSpdNELQFGPFVIKVASEEEaYANFVIRSFEILLTD--G--TQAKHYVKHFQFTAWPDHGV
 .| || |||...  ...||||.|. | || | . |||    .| |.|  ..|..|||.   ...||....  ..  .   .... |  ...|.|.|  |
eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskv

PDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQ
|..   |. ....| . . .  .||| ||||||||.|.|.|||. |.|.| |...| .... ..| ||  .|| ..|..||.  ||.    |.| . | .
PevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvdd

FSEII
... |
ledai
0037934 (Phosphotyrosine protein) phosphatases II 628-870 8e-72 237.0 In-house 5-240 (243) alignment 
Range on Protein: 628-870
Range on HMM: 5-240/243.0
SVANANRSKNRYKNIIPYDDNMIALqpiegwDEfqGQYINASYINGYNfknKFIATQGPLSSTTGD----LWRMMWQERSHVIVMLTNVIEGNRVKSEEY
.   .|.|||||..|.|||.... |      .   . ||||..|....   ..|||||||..|. |     |||.|.....||||||. .| .|.| ..|
allpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPpspdNELQFGPFVIKVASEEEaYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHY--------HAKLGGPIVTHCSAG
||    .| ..|.|.... |||. ......| ...  .| .. ...| |.....||||||||. ..|. |...|  .        ... |||.. |||||
wp....gevtygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTFIALDIGLEQMksenQIDFIQIINQMRDQRMH-MVQTINQFIFLHDTLLE
||||||.||... |...    ..|. ......|.||.. .||| .|..||.. |||
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN12_pd Subfamily PTPN12 628-872 1.3e-71 235.8 In-house 35-277 (290) alignment 
Range on Protein: 628-872
Range on HMM: 35-277/290.0
SVANANRSKNRYKNIIPYDDNMIALQPIEGWDefQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPS
. .. |. |||||.|.||| . . |. ||. .  . .||||..|.| . | ..||.||||. |  | |||.|. . ...||. ...| .. | | ||| .
gekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

PDNELQFGPFVIKVASEEEAYANFVIRSFEILLTdgtQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDI
 ..||.||.| ... .|.    .|.||....      .... |. |..|||||||||   ..|. ....| ... .   |.| ||||||||||| ||.|.
geeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidy

GLEQMKSENQ---IDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQV
  |..|.|.    .|  ... ..| ||  .||| .|. ... ...| |
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN3_pd Subfamily PTPN3 625-870 1.4e-71 235.7 In-house 33-273 (280) alignment 
Range on Protein: 625-870
Range on HMM: 33-273/280.0
HSLSVANANRSKNRYKNIIPYDDNMIALQPIEGwDEFQGQYINASyINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYW
 | .   .| |||||..|.|||.  . |.  |  |    .|.|   |.. .. |..|||||||..|. |.|.|.|...|..|||||...|  |||  .||
isaarkpenlsknryrdilpydatrvklkeset.dyinanyvnme.ipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PPsPDNELQFGPFVIKVASEeEAYANFVIRSFEILlTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIA
|  ...||..| | .|. .| ..  ..|.| . .     |. .. . ..|..|||||||||. . .. |...| ....    |.| |||||.|||| .|.
Pe.tedeleygefsvkceke.detksyvlrelvlk.dketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlil

LDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
|.. |  . .....  ..|. .|||||. .||| .|. |. ...|.
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 609-875 5.9e-71 233.6 In-house 16-296 (301) alignment 
Range on Protein: 609-875
Range on HMM: 16-296/301.0
NkpFNVLFSSLIRDTDH--SLSVANANRSKNRYKNIIPYDDNMIALQPIEGWDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVI
.  |.  ...| . .|.  .... ..|.  ||.||| .||||.| |.| .  |  | .|||||||.||. |.||||.|||. .|  |.||..|||.   |
k..feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLTNVIEGNRVKSEEYWPPSPDNELQFGPFVIKVASeEEAYANFVIRSFEILLTDGTQ--------------AKHYVKHFQFTAWPDHGV-PDHGSPLV
||.||  || . |.|.||| |  .. .|||| ... . | .| .||||.. . ..||..              . . |  .| | ||..|| ...   | 
vmvtnlkegtkskceqywpnseaeseefgpftvtlvn.eqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

IFmQKVMHYHAKL-GGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCG
.  ..|.|   |  |||.| |||..|.|.|......||||| |.|  .| .|... .| ... .|.|..|.....| . . . . 
vi.ddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_PTPN6_pd Subfamily PTPN6 629-869 6.8e-71 233.7 In-house 50-294 (306) alignment 
Range on Protein: 629-869
Range on HMM: 50-294/306.0
VANANRSKNRYKNIIPYDDNMIALQpiegWDEFQG-QYINASYING--YNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWP
  . |..|||||||.|.|.. . |.     .. .| .||||.||..   . ....||||| |..|  | |||.||| |.||||.|. .| .. |   |||
akpenkeknryknilPfDhtrvilk....epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWP

PSPDNELqFGPFVIKVASEeEAYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLG----GPIVTHCSAGVGRTGT
 . ..|  .|   ..  || .. |....|.. .  ..  . ...| ...|..||||||| . . .. |...| . . .|     |||| |||||.|||||
deeekee.yGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGt

FIALDIGLEQMKS---ENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLL
|| .|| |.....   . .||  ......|.||  .||| .|. |.. .. 
fiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_PTPN9_pd Subfamily PTPN9 629-872 6.3e-70 230.5 In-house 38-290 (297) alignment 
Range on Protein: 629-872
Range on HMM: 38-290/297.0
VANANRSKNRYKNIIPYDDNMIALQPIEGWDefQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSP
  .|| .||||.... ||.  . |. ... .  .  ||||....||. |. ||||||||  |. | |||.|...  |||| | |.|  |.|  .|||.. 
klranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWplee

DNELQFGPFVIKVASeEEAYANFVIRSFEILLTDGTQAKHyVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAK-------------LGGPIVTHCSAG
..  .|| . ... .  | . ....|..||  ..  . .. | ||||..|||.|||. .. |. ...|| .. |.              | ||| |||||
essaefgdlsvsnve.veeeedykvrvleiknvkteesrk.vthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaG

VGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQV
.|||||||.||| |.........| .. ....| || ...|| .|. | . ..||  
iGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 630-874 4.6e-69 227.4 In-house 6-244 (250) alignment 
Range on Protein: 630-874
Range on HMM: 6-244/250.0
ANANRSKNRYKNIIPYDDNMIALQPIEGwDEfQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVkSEEYWPPspD
  .|. |||| .||..|   . |.. .| |. .  |||||...||. .. ||||||||..|. |.|||...| | .||||||. | ...  ..|||   .
kpqnkeknryadiialdssrvvLekekg.dk.esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv..e

NELQFGPFVIKVASEEeAYANFVIRSFEILlTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAK-LGGPIVTHCSAGVGRTGTFIALDIG
.  ..|   ... |.|  .|....| . .      . .  |....|..||| |||..    . ...||   . .   .|.. .|||||||.|.|||.|  
kaekyGdvtvsllske.efadytkrklkls.kakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

LEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLC
||..| |...|  ..|...| .|.|.|.. .|..|..  .|. . .
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 631-892 2.7e-67 221.8 In-house 42-297 (315) alignment 
Range on Protein: 631-892
Range on HMM: 42-297/315.0
NANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDN
. | .|||||||.|.| . . |. |.  |. .  |||||||....  . .||.|||| ..  |.|||..||.   |||.|.  ||...|   |||    .
tinfkknryknilPldsarvklevid..dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

ELQFGPFVIKVASEeEAYANFVIRSFeilLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLE
  .|| . ... |  || .. |.| .    |  ..... |  |||| |||.||. . | |. ....|   . |   ... |||||||||| .|..|  ..
svefGsikvellsl.eadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevva

QMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQFSEIIGNFD
|.| .. .|  ......|..|...||| ... |..|..||..|  ||||.| .|.. . .. 
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 598-907 5.9e-67 221.1 In-house 11-323 (325) alignment 
Range on Protein: 598-907
Range on HMM: 11-323/325.0
EKYVEMQHLSDNKPFNVLFSSLIRDTDHSLSVA--NANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLW
 ..|| ..  |.  |   |  |  |   .  ||   .|..|||.||....| . . |.  .  |. .  ||||||.. .  |. |.|.| ||..|..|||
vehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkk..ddpssdyinasylrddkkkdvflaaqaPltatindlW

RMM--WQerSHVIVMlTNVIEGNRVKSEEYWPPSPDNELQFGPFVIKVASEEEAyANFVIRSFEILLTDGTQAKhYVKHFQFTAWPDHGVPDHGSPLVIF
|..  |.  . |.|. .|.....  .   |||    .  .||.. .|. . ||  ...| | ...  ... ...  || ||. .|.| ||. . . |. .
rlvldWr..csvvvv.lneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetr.svkqfqlqswddmGvqkrpatlisi

MQKVMHYHAKL------GGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQFSEI
.| | . . ..       .||. ||||||||||.||.|   |...  | ..|  . ....| .|  ||.|..|.|.....| | ...||| .||. |   
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

IGNFDYTDTKTKKTIYETQY
. ...  .  |.|   | ..
lsslqernpltqklniekef
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 632-870 3.7e-66 218.0 In-house 27-266 (274) alignment 
Range on Protein: 632-870
Range on HMM: 27-266/274.0
ANRSKNRYKNIIPYDDNMIALQPIEGWDEfQGQYINASYINGYNFKNK-FIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDN
 . .|||||.|.| .   . |.. .. || . .|||| || ||. ..| ..||||||..|  |.|||..||...||||||.. | |. | ..|.| . | 
gsqtknryktilPnensrvllesessede.dssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

EL--QFGPFVIKVASEEEaYANFVIRSFEILLTDGTQAkhyVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAK---LGGPIVTHCSAGVGRTGTFIAL
|.  ..| . ||| .  |   .. .|.. .. .  ..    |||. .|.|||| .||. ..|. ....| . . .     .|.| |||||.|||| ||| 
eiserygdveikvekive.rndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

DIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
.|.. |.. |. .| ..|. ..| .|  |||| .|. ..| .| .
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPN13_pd Subfamily PTPN13 621-870 3.9e-66 218.1 In-house 24-267 (273) alignment 
Range on Protein: 621-870
Range on HMM: 24-267/273.0
RDTDHSLSVAN-ANRSKNRYKNIIPYDDNMIALQPIEGwdefqgqYINASYINGYNFKNKF--IATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNR
. .|.. .  . .|..||||.|..|||.  . |.   |       |||||.|.    |...  ||.||||  |. |.|.|.|. ...||.|.|.  |...
kpldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk

VKSEEYWPPSPDNELQFGP-FVIKVAsEEEAYANFVIRSFEILLTDgTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAkLGGPIVTHCSAGV
|| . ||| | ...|.    . ...  . . . .||.|....  .. ... . | |..|..||||||| .  .|. |...| . .    ||||.|||||.
vkchrywPesknkklkvsnrlevell.kvqkldgfvvralavkdse.sgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGi

GRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
||.||.|..|. |. .. ....|  .|....|.||  .||| .|.|| . ..||
GrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 613-882 8.9e-65 213.4 In-house 13-276 (283) alignment 
Range on Protein: 613-882
Range on HMM: 13-276/283.0
NVLFSSLIRDTDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGwdefqgQYINASYIN---GYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVML
.||    . | |  ...|. |. |||...|.|.| ... |..         .||||..|     |. ..|.|..|.||  |  |.|.|...|.   ||||
evlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

TNVIEGNRVKSEEYWPPSpdNELQFGPFVIKVAsEEEAYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIV
|.. |..|.|   |||       ..|.| . .  .| .   |.|. . .     ....  . |.|.  | . |       || | . .     .  ||||
tklqedlrikCsqyWPkr..GsedyGeftvtlr.kettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPiv

THCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVA
 |||.|.|||..|||.   ......|  .|  .... || ||| .||| .|. ..|.  ||| |||.| |   
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaav
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 623-885 3e-64 212.1 In-house 38-293 (439) alignment 
Range on Protein: 623-885
Range on HMM: 38-293/439.0
TDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGWDefQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRvksee
 . ||   . ...|||||.. ..|   ..|| | |    . .|||| ||.||  .. .||||||   || |.||.......  ||||||..|  .     
ciaslaaqeydqtknrykdvgafdhtrvtlqeipgvp..hshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....

YWPPspDNELQFGPFVIKVASEEEaYANFVIRSFEILLT-DGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHY-HAKLGGPIVTHCSAGVGRTG
|||   |.|  .|  ...|  . |   |.||| | ..   | |. .. | .|...||||. || . | .. |.. .      .  ||.| ||||||||||
ywps..daevcygdiavrvdrnie.lpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtG

TFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQF-S
| ||||| |||.|.||..|   |.. .|.|| .|||.. |..|.....||..  |.. . . .|  
tiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 626-870 2.9e-63 208.4 In-house 13-262 (270) alignment 
Range on Protein: 626-870
Range on HMM: 13-262/270.0
SLSVANANRSKNRYKNIIPYDDNMIALQPIEGwdEFQGQYINASYINGYNF-KNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYW
.|  |  ..  |||..|.|     . |...|   . . .|||| |..|..  |.|.||..||| .|. . |||.|.|... |||.|.. | .| | | ||
dlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYW

PPSPDNELQFGPFVIKVASEEEAYANFVIR-SFEILlTDGTQAKHYvkHFQFTAWPDHGVPDHGS------PLVIFMQKVMHYHAKL--GGPIVTHCSAG
|..|......    |||....|. ... |.   ..  ..|.. .    ||....||||||| .         |.  ...| ... .|  ..|...|||||
paepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaG

VGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
||||||.|||||... .......| ..||...| .|| .||. .|. ||. ...|
vgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 589-884 1.5e-61 203.1 In-house 7-296 (297) alignment 
Range on Protein: 589-884
Range on HMM: 7-296/297.0
HKPIPADTLEKYVEMQHLSD--NKPFNVLFSSLIRDTdhSLSVANANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFknKFIATQGP
 .|||   .  .|. .. .|  .. |. | .. |. .    .  . | .|.|||||.||| . . |. ..  |. .  |.|||...|..   ..|.|| |
rrpiplsdfatlvqknrhtdvfseeflclpeaniqpq..tvaekkvnfeksRYkniLPydssRvkLaivn..ddpdsDyvnasfvkgnkh..rlittqmP

LSSTTGDLWRMMWQERSHVIVMLTNVIEGNRvKSEEYWPPSPDNElqFGPFVIKVASEEEAyANFVIRSFEIllTDG-TQAKHYVKHFQFTAWPDHGVPD
  .|  |.|.|...|.  .||||..  |... |   ||. .  ..  ||  .... | .|    |. |..|.  | | ..|.. || .||. |||. |. 
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvser.eGfikrelev..tkgkakarrvvkqyqfveWPdkaver

--HGSPLVIFMQKVMHYHAKLGG-PIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVA
  . | |. ... | . . .    |.. ||.||||||| ....|  . ..| |...|  ......|..|...||| .|. |.. ..|| .|. .| |...
kdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas

QF
 |
yf
subfamily_CG7180_pd Subfamily CG7180 624-876 6.3e-60 197.3 In-house 33-294 (296) alignment 
Range on Protein: 624-876
Range on HMM: 33-294/296.0
DHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGWDEFQgqYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRvKSEEY
|    . . || |||. ...||| | . |. ..| .. .  ||||.|....  |...| |..|  .| .. ||....| .. .|.||.. . .. .  .|
dCagglrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPPSPdnELQFGPFVIKVAsEEEAYANFVIRSFEILLT--------DGTQ-AKHYVKHFQFTAWPD-HGVPDHGSPLVIFMQKVMHYHAKL-----GGPI
||.    . |.|......  ||. |||..|| | .  .         . .  .  ||.||.| |.  . ||   . |. ....|  .  |       ||.
wpnks..keqygeifveiv.eekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPv

VTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGN
| ..| |..|.| ..|.|. ||... |...|. . . ..| .| ..|...... .. |.||| |||. 
vvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_PTPN23_pd Subfamily PTPN23 623-872 2.2e-59 195.6 In-house 33-280 (288) alignment 
Range on Protein: 623-872
Range on HMM: 33-280/288.0
TDHSLSVANANRSKNRYKNIIPYDDNMIALQpiegwdEFQGQYINASYINGYN-FKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSE
 ..|...|. . .|||...|.||| | . |.      . .  |||||....      .|||||.|| || .| |.|.....| |||||..  | .. | .
rkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvd

EYWPPSPDNELQFGPfvIKVASEEEAYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMH-YH---AKLGGPIVTHCSAGVG
.||| . ..  .||.  ..|. ...  .. ...   .| | ...|.. |.| |.|.||..|||.  . |. |...| . |.    |.  |.| |||||||
rYwPedkgetvkfgd..lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvg

RTGTFIALDIGLEQMKSENQI-DFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQV
|||.|  .   ..... .| . | ||.....| || .|||. .|. |. .  ||..
RtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 632-870 6.8e-58 190.7 In-house 2-237 (237) alignment 
Range on Protein: 632-870
Range on HMM: 2-237/237.0
ANRSKNRYKNIIPYDDNMIALQPIEGWdefqGQYINASYINGYNFK-NKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPpSPDN
 |. |||| ||. || . . |.   .      .||||.|..|..   .|.||.|||| |.  |.|.|.|||.  |||||| .||||..|  .||| | |.
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdq

ELQFGPFVIKVASeEEAYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHY--HAKLGGPIVTHCSAGVGRTGTFIALDIG
   .| . . .   .|..... .||. .      .   ... .|||.|||.|||.. . |. | .....   |    || . |||||||||| |. .|  
paaygvltvslkk.keefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam

LEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
| | | .. .|  . .  . ..| ...|| .|..|.|.|.||
lrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 632-870 1.1e-57 189.9 In-house 6-238 (239) alignment 
Range on Protein: 632-870
Range on HMM: 6-238/239.0
ANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKNK-FIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDN
 |..|||| ||. || . . |. .   .. . .||||||.  |.   | .||||| .. ..||.||||||||  |||||| .||| . |  .||| |  .
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

elqFGPFVIKVaSEEEAYANFVIRSFeILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLE
   .  . . .  . | .|...||.| ..   |   ..|| ...|| |||.|||.. . .. . .|. .       | | ||||||||||.|. .|  | 
...ycnlrvtl.rktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

QMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
| | .. .| .. .. .|..| ||||| .|..|.| ..||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 632-870 1.6e-57 189.4 In-house 7-239 (239) alignment 
Range on Protein: 632-870
Range on HMM: 7-239/239.0
ANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKNK-FIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDN
 |..|||| ||. || . . |. .   .. . .||||||.  |.   | .||||| .. ..||.||||||||  |||||| .||| . |  .||| |  .
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

elqFGPFVIKVaSEEEAYANFVIRSFeILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLE
   .  . . .  . | .|...||.| ..   |   ..|| ...|| |||.|||.. . .. . .|. .       | | ||||||||||.|. .|  | 
...ycnlrvtl.rktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

QMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
| | .. .| .. .. .|..| ||||| .|..|.| ..||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN1_pd Subfamily PTPN1 623-872 9.4e-56 183.6 In-house 22-271 (290) alignment 
Range on Protein: 623-872
Range on HMM: 22-271/290.0
TDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEGwdefqgQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEE
 ... .  ..||..|||... |||   | |.  .       .||||| ..  . | ..| |||||..|.. .|.|.|...|. .||| .|.| ...|  .
fptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPPSPD-NELQFG--PFVIKVASEeEAYANFVIRSFEilLTD-GTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYH--AKLGGPIVTHCSAGV
|||   . .||..    . .|. || | . ....| .|  |..  ||  . . || .|.||| |||.  . .. |..|| .    ..  || | |||||.
ywPqgeeekellledtklkvklise.erksyytvrlle..lenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRTGTFIALDIGLEQMKSENQ---IDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQV
||.|||. .|  | ... ...   .|  . . ..| .|. ..|| .|. | . ..|| .
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 626-892 3.5e-55 182.0 In-house 38-256 (392) alignment 
Range on Protein: 626-892
Range on HMM: 38-256/392.0
SLSVANANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNrvkseeywp
. .  . |  |||||||.||| . . |. |.  |  . .|.|||||.... .. .||.||| ...  |.|||..||.   |.|.|.. ||.         
tvaqkeinlkknryknilpydsarvklevid..dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

pspdnelqfgpfvikvaseeeayanfvirsfeilltdGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIAL
                                       . .. |  |.|| |||..|| | | |. |...|   . .   |.. ||||||||||  |..
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

DIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIPVAQFSEIIGNFD
|  . . |    .| .... ..| .| .|||| .|. |.. ..||..|  |||||| .|.. . ...
dsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls
subfamily_PTPN14_pd Subfamily PTPN14 622-870 7.1e-55 181.1 In-house 38-294 (300) alignment 
Range on Protein: 622-870
Range on HMM: 38-294/300.0
DTDHSLSVANANRSKNRYKNIIPYDDNMIALQPIEgwdEFQGQYINASYINGY--NFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVK
|.. | .  . | .|||.|...||.|| . |.| .   | . .||||| |.      . ..|..||||  |  | |.|.|..  ..|||||. .|. . |
dallstaklpenaeknrfkdvlPyednrvelsptk...enstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

SEEYWPPS--PDNELQFGPFVIKVASEEEAyANFVIRSFEILLTDgTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVM--HYHAK-------LGGPI
| .|.| .    ....|| | .     |..   .. .....     .. .  | |.|.| |||||||.  .. . ....|    ....          |.
sfkyfPkleskkktvefgkfkvttkfseds.dsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

VTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
. ||||||||||  |  |. .. .. ...||  ......| |||..|||. |. |....|..
lvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
0041856 (Phosphotyrosine protein) phosphatases II 633-880 1.8e-51 169.7 In-house 1-179 (182) alignment 
Range on Protein: 633-880
Range on HMM: 1-179/182.0
NRSKNRYKNIIPYDDNMialqpiegwdefQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTnviegnrvkSEEYWPpspdnel
|..||||..|.||| ..               ||||... |.   ..|||||||| ||. | .||..... ..||.||         .| |||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

qfgpfvikvaseeeayanfvirsfeilltdgTQAKHYVKHFQFTAWPDHGVPDhgsplVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQm
                               .  .... ..... ||||||||     .  . . ..   . |||.. |||||||||||..|... ... 
...............................ellerlgiqylylpwpDhgvpd.....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.

ksenQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLCGNTLIP
    .... ......| .|..||.| ||..||.. ||| .|...| ..
....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 632-869 4e-51 168.5 In-house 37-274 (287) alignment 
Range on Protein: 632-869
Range on HMM: 37-274/287.0
ANRSKNRYKNIIPYDDNMIALQPiEGwdEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSpDNE
|. .|||| ...|.||. . |   ||  |.  .|||| |. .|. ...|||.|||...| .|.||.....|| .....|  .|  | |  .|||   .  
aavkknryadvlPiddtrvllsa.eg..elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evP

LQFGPFVIKVASEEEAYANFVIRSFEILLTDGTQAkHYVKHFQFTAWPDHGVPDHGSPLVIFMQKV-----MHYHAKLGGPIVTHCSAGVGRTGTFIALD
.. | . . . . .    .. .|.. ..  .. .| . || ... .|||....     |. |. .|     .   |.  ||.| |...|.||.|...|. 
mrvGGysvvlldydikePeygvralrlidletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

IGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLL
. ......  ..|  ... ..| .|  .||.. |. .| ..| 
vlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPRN_pd Subfamily PTPRN 625-872 6e-51 167.9 In-house 48-292 (297) alignment 
Range on Protein: 625-872
Range on HMM: 48-292/297.0
HSLSVANANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYNFKN-KFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEY
.... |. | .|||.|...|||.... |.     .. . .||||| |   . ..  .|||||||.||  |.|.|.|.. . |||.||.. | .  . ..|
kevakaeknvkknrskavlpydhsrvklkeea..saeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPPSPDNelQFGPFVIKVASEEEAYANFVIRSFEILLTDgTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFI
||    .   .. . ... ||     ....||| .   . |.    |  | | .||..|||    .|. | .||   .     ||| |||.|.||||..|
wpdeGse..vyhiyevhlvsehiwcddylvrsfylknlq.tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyi

ALDIGLEQM-KSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQV
..|. |... |  ..|| .  .. .|||| ..|.| .|| |   .. |.|
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
0051429 (Phosphotyrosine protein) phosphatases II 664-871 8e-51 168.6 In-house 5-224 (272) alignment 
Range on Protein: 664-871
Range on HMM: 5-224/272.0
QYINASYINGYNF---KNKFIATQGPLSSTTGDLWRMmWQERSHVIVMLTNVIEGNRVKSEEYWP----------PSPDNELQFGPFVIKVASEEeAYAN
 ||||....||.    ........|||  |  |.||. .... ..||.|... | .|.| . |||          .. . .  .| ..... |||  . .
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee.llld

FVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGspLVIFMQKVMHyhaklGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQID--------FIQ
...| ... |. .... . | |...|.|||||||..   |. ... . .     |||.. |||||..||||..||.. |...  |  .|          .
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

IINQMRDQRMHMVQTINQFIFLHDTLLEQ
.....|.||...|||  |..||.. ||| 
aveelraqrpgavqteeqylflyeallel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 627-870 3.4e-48 158.8 In-house 50-281 (290) alignment 
Range on Protein: 627-870
Range on HMM: 50-281/290.0
LSVANANRSKNRYKNIIPYDDNMIALQpiegwDEFQGQYINASYINGYnfKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPP
.  .|..  |||||...  |   . |.     | ..|.|. | |..|   |  || |||.| .|. |.|||. ||.  .|||| ..||  . | |.|.| 
ifdkntefkknrykdvvcndktrvilk.....dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype

SPDNELQFGPFVIKVASEEEAYANFVIRSFEILLTDGTqAKHYVKHFQFTAWPDHGVPDhgSPLVIFmqKVMHYHAKLGGPIVTHCSAGVGRTGTFIALD
   . | || . .  . |..  || . . . .   |    .| .||..  .|||. |.   | | ..  ....   |. ||.| |||||.||||||.|..
keGevltfGeitvlcseeddkdaniikktlsvrdkdsG.kehklkhlkikswpdksval..stlall..rtlrilrkasGpvvvhcsaGiGrtGtfvaie

IGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLE
.||. .    ..| ....  .|. |.  ||   |.. | . ||.
vglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 622-871 4e-45 148.9 In-house 21-258 (267) alignment 
Range on Protein: 622-871
Range on HMM: 21-258/267.0
DTDH-SLSVANANRSKNRYKNIIPYDDNMIALQPIEGWdefqgqYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRvks
..   | |.|. |. .||. . .||||... |.  |        ||||||..||. ||.||.||.||. | .| . .. ...  |||.||.| ..|    
tsstisqsiaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdni...

EEYWPPSPDNELQFGPFVIKVASEEEAyANFVIRSFEILLTDgtQAKHYVKHFQFTAWPDHGV-PDHGSPLVIFMQKVmhYHAKLGGPIVTHCSAGVGRT
  .|||   .  ..  .... . |.|   .. | ..|. . .  .. | |  . .  |        .  ||.  . |      . . |.| .||.||||.
rlfwPPkmgqakkyqdltvehslekee.ndyqiitlelkfkn..esahnvtlyyykkwnintnnkpylkplfgilakn..qlengnrPlvvacsdGvGrs

GTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQ
|||. .|  ||..| |.  |  . . ..|.||. .|.| ...|..|..| | 
Gtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0036282 (Phosphotyrosine protein) phosphatases II 664-866 7.2e-45 148.1 In-house 3-164 (174) alignment 
Range on Protein: 664-866
Range on HMM: 3-164/174.0
QYINASYINGYNFKNKFIATQGPLSsttgdLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPspdnelqfgpfvikvaseeeayanfvirsfeilltDG
 |||||.....   ...||.||||.      |.|.........|||.. .| ...|   |||                                    . 
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................lr

TQAKHYVKHFQFTAWPDHGVPDHGSpLVIFMQKVMHYHAK-LGGPIVTHCSAGVGRTGTFIALDIGLEQMKsENQIDFIQIINQMRDQRMHMVQTINQFI
.  .... ..... ||||||||    |  |.. | .....  |||.. |||||||||||..|... | ... |. .| .... ..| ||..|||| .|..
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FLHD
||..
flyy
0043147 (Phosphotyrosine protein) phosphatases II 664-865 1.2e-43 144.2 In-house 6-154 (172) alignment 
Range on Protein: 664-865
Range on HMM: 6-154/172.0
QYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNViegnrvkseeywppspdnelqfgpfvikvaseeeayanfvirsfeilLTDG
 ||||||...|   ..||||||||..|. | |||....  ..||.||.                                                |.|.
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................lydp

TQAKHYVKHFQFTAWPDHGVPdHGSPLVIFMQKVMH-YHAKLGGPIVTHCSAGVGRTGTFIALDIGLeqmkseNQIDFIQIINQMRDQRMHMVQTINQFI
.. .... ..... ||||||| . . |  |.. . . .. . |||.. |||||||||||..|... |       .... ......|..|...||. .| .
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FLH
||.
fly
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 620-873 9.6e-43 141.3 In-house 26-278 (307) alignment 
Range on Protein: 620-873
Range on HMM: 26-278/307.0
IRDTDH--SLSVANANRSKNRYKNIIPYDDNMIALQpiegWDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNR
 . | .  .    .||  ||||...   | . | ..     |    .|| | |.      .|||..|||| .|  ..| |. ||.   ..|| .|||  .
akktpegvtveafsantdknryqdvkcqdkgrivvk....fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielak

VKSEEYWPPSPDNELQFG--PFVIKVAS---EEEAYANFVIRSFEILLtDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQkVMHYHAKlggPIVTHC
.| |.|||    ..| ||  |  | ||    .. |  . .|   .. . | .|    ..|.|.. |||.|||.     . ...  ..|.     |.| ||
ikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkv.dwaqksrtiqhlqwenwpdrgvpqinltainlle.avrydtn...pvvvhc

SAGVGRTGTFIALDIGLEQM-KSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVL
||||||.|| .|. .  ..| . .|  |  ......|.|| . .||  |...||  |||  |
saGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
0046846 (Phosphotyrosine protein) phosphatases II 661-869 6.1e-42 138.7 In-house 10-170 (176) alignment 
Range on Protein: 661-869
Range on HMM: 10-170/176.0
FQGQYINASYINGYnfknKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDNELqfgpfvikvaseeeayanfvirsfeill
.   ||||..| |.    ..||||||| .|. | ..|..... ...|.||. .| .|.|   |||   ....                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

tdgtqakhyvkHFQFTAWPDHGVPDHgsPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDigleQMKSENQIDFIQIINQMRDQRM-HMVQTIN
           ..... ||||||||.   |.. . . .. . | |||.. |||||.|||||..|..     ...|....  ... ..|.||. ..||| .
...........qylhlpwpDhgvpdl..elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QFIFLHDTLL
|  ||.. .|
Qyrflyefel
0049260 (Phosphotyrosine protein) phosphatases II 670-866 1e-40 134.2 In-house 1-144 (152) alignment 
Range on Protein: 670-866
Range on HMM: 1-144/152.0
YINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWppspdnelqfgpfvikvaseeeayanfvirsfeilltdgtqakhy
.|.||. ...|||||||.. |. | |||...   ..|||||.  | ...| |.|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

vkHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLeqmkseNQIDFIQIINQMRDQRMHMVQTINQFIFLHD
  ..... ||||||||.   | .... . ..  . |||.. |||||||||||..|... |      ..... ......| .|...|.. .| .||..
..qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 633-871 8.6e-40 131.3 In-house 48-286 (305) alignment 
Range on Protein: 633-871
Range on HMM: 48-286/305.0
NRSKNRYKNIIPYDDNMIALQPieGWDEfqgQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDNEL
.. |||||..   |.| . |..   |     .|| | |.      ..|| || ||  |  |.| | .|.. . | || |..|    |  ||..   ...|
eagknrykdvgcldnnrvkleg..pwph...eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

QFGPFVIKVASEEEA--Y------ANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMhyhaKLGGPIVTHCSAGVGRTGTFIA
.|     |..   |.         |. ...  ....    . .. |.|. .  ||| |||     .. ...|       . |||| |||||.||||. . 
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtgsvvm

LDIGLEQMKSENQIDFI-QIINQMRDQRMHMVQTINQFIFLHDTLLEQ
|.  |.|. . ..|.   .|....|.||   .|| .|..|.|. .|. 
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
0049772 (Phosphotyrosine protein) phosphatases II 630-872 1.1e-39 132.4 In-house 43-280 (314) alignment 
Range on Protein: 630-872
Range on HMM: 43-280/314.0
ANANRSKNRYKNIIPYDdNMIALqPieGWDEFQGQYINASYINGYnfkNKFIATQGPLSSTTGDL----------WRMM--WQERSHVIVM---------
  .||.||||..|.|.| |   | |  |.. .   ||||||..|.   .|||||||||. |  |.          |||.  .. ....|||         
lflnrdknryldilpad.nrvil.p..glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTNVIEGNrvkseEYWPPSPDNELQfgpfvikvaseeeayanF-------VirsfeilltdgtqaKHYVKHFQFTAWPDHGVPdhGSP
            |... ...      .....   .|.                         .              .... ..  . .||...|   . 
lsrLdaAlgKtpllildgng.....neptaadlellk.................eelydpelf..............erlgikylripvpDgsap..lle

LVIFMQKVMHYHaKLGGPIVTHCSAGVGRTGTFIALDIGLEQMksenQIDFIQIINQMRDQRM-----HMVQTINQFIFLHDTLLEQV
 .  . .... . . |||.. ||.||.||||||..... . ..    .... ......| .|.     ..... .|..| .. ||| .
dfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 626-864 4.6e-39 129.0 In-house 43-273 (301) alignment 
Range on Protein: 626-864
Range on HMM: 43-273/301.0
SLSVANANRSKNRYKNIiPYDDNmIAlqpIEGWDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWP
  | |  .. |.||... | . .  |   .|  .. .   | | .|.     ..||||||||..|. |.| |. |   . ||||.. .| .  | ||| |
tesyaylpkdkhryptv.PckPs.ta...vevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylp

PSPDNELQFGPFVIKVASEEEAYAN-FVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVifmqKVMHYHAKLGGPIVTHCSAGVGRTGTFIA
 .. ..|. | | ||. ..|    .  . |..|.  . |  | . | |.|.. |.|.|||     |     ..|.   |   ||| |||||.||. .||.
vkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelf....dlmelvkksekPivvhcsaGiGrsvafig

LDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFL
 ..   .......|.. . ....|..| . ||| .|. ..
teylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 632-873 3.4e-38 126.3 In-house 42-272 (288) alignment 
Range on Protein: 632-873
Range on HMM: 42-272/288.0
ANRSKNRYKNIIPYDDNMIALQpiegwDEFQgQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDNE
|| ...||.|.   |   . |.     |. .  ||.|  .   ..|...| .| || .| . ||.|. ..  . ||||....|  . ||.||.|    ..
anptrdryenlprcditrvkls.....ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

LQFGPFVIKVASEEeAYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVmhyhAKLGGPIVTHCSAGVGRTGTFIALDIGLEQ
 ..| .   |  .  |  . ...   .  .  .. | .||.  .  |.|.|||.   . . ... .     .|  ||| |.|||||||||.|   | ||.
arigrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililiales

MKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVL
.......   ......|..|.. .|| .|....|  .||..|
lrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 616-870 9.2e-38 124.5 In-house 17-267 (281) alignment 
Range on Protein: 616-870
Range on HMM: 17-267/281.0
FSSLIRDTDHSLSVA---NANRSKNRYKNIIPYDDNMIALQpIEGWDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNV
|| |  |    |  .     |  |||| ||   |   . |. ..  ..   .|| | ||    .|  .| ||||   |  |.|||.||| .  |||| ..
fsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlk.vkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqf

IEGNRVKSEEYWPPSPDNELQFGPFVIkvASEEEAYaNFVIRSFEILLTDGTQAkHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVmhyHAKlGGPIVTHC
.| || |  ||.|      |||  . .  . |. .  |  . .  . |.   .. . . |. .  |||  ||.    ..  ..|.   .|.   | | ||
letnrekcaeyfprnahcclqfdklsv..syedstv.nkslvttrlnlsyeget.rlithwlwkewpdwqvpessevmlkilrki...rar.stppvihc

SAGVGRTGTFIALDIGLEQMKSENQI-DFIQIINQMRD-QRMHMVQTINQFIFLHDTLLE
||||||.||..|..| |. ..|   . |  ||. ..|   |   |||..|....   ||.
sagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 630-873 1.2e-36 121.2 In-house 32-271 (285) alignment 
Range on Protein: 630-873
Range on HMM: 32-271/285.0
ANANRSKNRYKNIIPYDDNMIALQpiegwdEFQGQYINASYINGY-NFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSP
 .||   ||| ..   ..  . |.      ... .|| ||..    . .. .|.|||||  |  |.|.|..||.   ..||  ..||   |   |.|   
yeanpdlnryadvrcieetrvvlk......nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

DNELQFGPFVIKVA-SEEEAYANFVIRSFEILLT-DGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKlGGPIVTHCSAGVGRTGTFIALD
 . ..|| . | ..  .||| |  .. .. .. | | .    |..| |   |||.  |.   |.. . . | .   |   ||. ||||||||| ||. .|
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgid

IGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVL
    ..  . .|....|. .||  |.. ||.  ||.||.  |.| ..
yatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
PTPc_DSPc_SM00012 770-870 1.9e-36 119.8 In-house 2-105 (105) alignment 
Range on Protein: 770-870
Range on HMM: 2-105/105.0
VKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLG--GPIVTHCSAGVGRTGTFIALDIGLEQMKSE-NQIDFIQIINQMRDQRMHMVQTINQFIFLHD
|||...|.|||||||....... ....|.. . | .  .|.| ||||||||||||.|||| |.|...| ...|. ||....|.||..|||| .|..||..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TLLE
 |||
alle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 630-873 8.3e-36 118.2 In-house 52-290 (305) alignment 
Range on Protein: 630-873
Range on HMM: 52-290/305.0
ANANRSKNRYKNIIPYDDNMIALQPIEgwdefQGQYINASYINGYNF-KNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSP
|. . .||||...   | ... |.          .|| | |.      ...||..||||  |  ..| |. |..   |||| . .|  ..|  .||| . 
adiaitknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

DN--ELQFGPFVIKVASEEEAYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHyhAKLggPIVTHCSAGVGRTGTFIALD
 .  ||. |  | .|.       .  |.   . ||   . |  |.|.|.| ||| |||      . ..  .    .|.  ||| |||||.||||| .|..
geklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg..skv..pivvhcsagigrtgtivaie

IGLEQMKSENQID-FIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVL
  ||..  ...   . .... .|||| . .|.  |..|.|  .|. .|
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_ptpA1_pd Subfamily ptpA1 629-829 8.4e-35 115.3 In-house 43-253 (418) alignment 
Range on Protein: 629-829
Range on HMM: 43-253/418.0
VANANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYnFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSP
  . | ||||| ||.| .   . |. |.  |.   .|||| ||.|  . ..||.|||||  |  |.|||.|..| ..||||.   |  |.| . |||   
dkkhntsknrytnilpvnhtrvqlkkiq..dkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

DNE---------LQFGPFVIKVASE-EEAYANFVIRsfEILLTDGTQAKHyVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHA------KLGGPIVTHC
  |           || . ...    ..   . . |  .| ||   ...  . ..|.  |||| .|||  |.  ... .   .           ||. ||
ggeqfsiygngnevfgtysvelveviqdpereiitr..nirltfegetrd.itqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc

SAGVGRTGTFIALDIGL
|||||||||| .  | .
sagvgrtgtfctavimm
0051082 (Phosphotyrosine protein) phosphatases II 664-869 1.4e-34 114.2 In-house 4-150 (151) alignment 
Range on Protein: 664-869
Range on HMM: 4-150/151.0
QYINASYINGYnfknkFIATQGPlsstTGDLWRMMWQERSHVIVMLTNVIEGNrvKSEEYWPPSPdnelqfgpfvikvaseeeayanfvirsfeilltdg
 |||.||. |.     .....||    . | .......   .||.|..  | .  .  ||.|                                      
dyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg...................................

tqakHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHyhaKLGGPIVTHCSAGVGRTGTFIALDIGLeQMksenqIDFIQIINQMRDQRMHMVQTINQFIF
    . |.|.... |||.|.|..   .. |......   | .||.. |||||.|||||..||.. | ..     ... ......| .|...||. .||.|
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqflf

LHDTLL
..  ||
qlfall
0044763 (Phosphotyrosine protein) phosphatases II 645-869 2.3e-33 110.7 In-house 2-168 (178) alignment 
Range on Protein: 645-869
Range on HMM: 2-168/178.0
YDDNMIALQPIEGWdeFQGQYINASYINGYnfknKFIATQGPlssttGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDnelqfgpfvikvase
.|..   |...||.  . ..|||||.| ..     ......|      | .......  ..||.||. .|....|. .||| . .               
ldrtrvllsnlegl..ersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

eeayanfvirsfeilltdgtqakhyvKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQmksenQIDFIQII
                           ..... .|||||||  . .  |.. . ..... |||.. ||||||||.||..|... ...     .... ..|
..........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

NQMRDQRMhMVQTINQFIFLHDTLL
...| .|. .|.. .|  .|..  |
elvrerRp.ivpnpgqlrqLyefel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 630-867 9.2e-33 108.1 In-house 49-285 (310) alignment 
Range on Protein: 630-867
Range on HMM: 49-285/310.0
ANANRSKNRYKNIIPYDDNMIALQpIEgwDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPD
 . .  |||| ...  |.  . |. |.      ..|| | |..   ... || .||||  |  |.|||..|||.  |..| .| |  | |.  |||    
ykkymhknrysdvvcldtsrvklk.id..ksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgv

NElQFGpfVIKVASEEEAYANFVIRSFEILL------TDGTQA---KHYVKHFQFTAWPDHGVPDHGSPLVifMQKVMHYHAKlgGPIVTHCSAGVGRTG
 |  .|  .|.|.   |.  .| |  . . .       |   |   .  |.  ..  ||| ||||     |   |...    .  || | |||||..|..
te.tyg..cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv..pqrllaqvrh..gpcvvhcsagkdrly

TFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDT
. .||.. .....  ...|. ... ... .|.  .||  |.....  
vvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 624-797 1.4e-32 107.7 In-house 22-193 (297) alignment 
Range on Protein: 624-797
Range on HMM: 22-193/297.0
DHSLSVANANRS--KNRYKNIIPYDDNMIALQPIEGwdefQGQYINASYINGYNF--KNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVK
  |.|.|. | |  ||||..|. .||. . |.        . .|||| |.   .   . |.| .|||||.|  | |......   ||||.... |. | |
gesfssakrnsslrknryrdilatddtrvkllrvit....erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdk

SEEYWPPSPDNELQFGPFVIKVASEEE-AYANFVIrsFEILLTDGTQAKHyVKHFQFTAWPDHGVPDHGSPLVIFMQKV
   ||| . .. |. | .|..  |.    . . ..   |. |   .. .. |.| || .|||||||     || |  .|
capywpsvvqerlkagdvvveflsstsdefdrvil..telqliyrsesrv.vrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 879-1006 9.1e-32 105.2 In-house 2-125 (287) alignment 
Range on Protein: 879-1006
Range on HMM: 2-125/287.0
IPVAQfseiIGNFDYTDTKTKKTIYETQYQLIKRLTPKTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSDNDYINASYVDGYQKKKEFIIAQSPLEQ
||| .    .|.|  ..... .. ...|.......| .      .|  .  .||| .  |. |  ||.|.. ..|||||...|||..||.||||.||. .
ipvek....fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfn

TTLDFWKMIIQHKTSTILMLCNLSEDSK
|  .|||.| ... ..|.|||.. |. .
tarnfWkliddrnvtaivmlcqekende
subfamily_egg_pd Subfamily egg 625-869 5.3e-31 102.4 In-house 32-267 (307) alignment 
Range on Protein: 625-869
Range on HMM: 32-267/307.0
HSLSVANANRSKNRYKNIIPYDDNMIALQPIEGwdEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVksEEYW
   .... |. | | | .   |   ..|.  .|   . ...| | ...|  . |.|| .| ||  |  |.|||..||. . |||||   | .|   | ||
lttaasdnnlekarskrvhckdssrvklelrrG..qylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserc..eyyw

PPSPDNELQF--GPFVIKVA-SEEEAYANFVIRSFEIllTDGTQAKHYVKHFQFTaWpdHGVPDHGSPLvifmqKVMHYHAKLGGPIVTHCSAGVGRTGT
| .... |..  | . |.    ...|   | .  . .    | . . ...|.|   .  . . |  |||     .|.    .|  |.| ..  || ...|
pkaesdslvtvpGslrienlkvdskadplfrvtklkl..vGgddeerflehwqgd.v..nnssdvyspl.....rvlrklrnlskpvvvqdilGvskaat

FIALDIGLEQMKSE--NQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLL
..|..| | ..      .    . .  .| .|   |... ...|..  .|
lvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0051299 (Phosphotyrosine protein) phosphatases II 876-1005 1.1e-30 102.5 In-house 2-130 (288) alignment 
Range on Protein: 876-1005
Range on HMM: 2-130/288.0
NTLIPVAQFSEIIGNFDytdtKTKKTIYETQYQLIKRLTPKtTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQ----SDNDYINASYVDGYQKKKEFII
.| |.| .. . . ..     .. .|... ... . .|.|.   ... .    .||||    || |  ||.|.     ...|||||||.|||..|..||.
dteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

AQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDS
.| ||..|. |||.|. ......| ||..| |..
tqgPlpntvedFWrmvweqnvrvIvmltklvelg
0047943 (Phosphotyrosine protein) phosphatases II 895-1006 1.2e-30 102.3 In-house 6-116 (273) alignment 
Range on Protein: 895-1006
Range on HMM: 6-116/273.0
DTKTKKTIYETQYQLIKRLTPkTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTST
.... .|... ...|...|.|    |.. .  . ..|||    || |  ||.|.....|||||||||||..|..||..| ||..|. |||.|. ......
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

ILMLCNLSEDSK
| ||..| |...
iVmLtelvelgr
0050432 (Phosphotyrosine protein) phosphatases II 895-1005 1.6e-30 101.9 In-house 36-146 (308) alignment 
Range on Protein: 895-1005
Range on HMM: 36-146/308.0
DTKTKKTIYETQYQLIKRLTPkTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLqQSDNDYINASYVDGY--QKKKEFIIAQSPLEQTTLDFWKMIIQHKT
. .. ....|.... . ...|    |..    . ..|||    || |  ||.| ....|||||||||||   ....||..|.||..|. |||.|. ....
ekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnv

STILMLCNLSEDS
..| ||..| |..
rvIvmLtklveng
0036941 (Phosphotyrosine protein) phosphatases II 897-1006 5.7e-30 100.1 In-house 9-117 (297) alignment 
Range on Protein: 897-1006
Range on HMM: 9-117/297.0
KTKKTIYETQYQLIKRLTPkTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTIL
.. ......... . .| .    ... .  . .||||    || |  ||.|.....|||||||||||. |..||..| ||..|. |||.|. ......|.
llflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLCNLSEDSK
||..| |. .
mltelvelgr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 769-906 3.6e-29 96.3 In-house 90-228 (440) alignment 
Range on Protein: 769-906
Range on HMM: 90-228/440.0
YVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLG-GPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDT
 .|.... .|||.|||   .|.. ..| | . . | | ||.. |||||.||||  ||.|  | . |  .||| . .|| ||..| .|||| .|. |.|..
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea

LLEQVLCGNTLIPVAQFSEIIGNFDYTDTKTKKTIYETQ
.|| .|||.|||   . .| . . .. . .| |.  . .
vlegllcgdtliledditerveqiqwpnphtdksplqqe
0045450 (Phosphotyrosine protein) phosphatases II 892-1006 7.2e-29 96.9 In-house 18-146 (307) alignment 
Range on Protein: 892-1006
Range on HMM: 18-146/307.0
DYTDTKTKKTIYETQYQLIKRLTPK-TTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQ-----SDNDYINASYV--------DGYQKKKEFIIAQSPLE
 ...... .|... ... ....|..    |..      ..|||    || |  ||.|.      .|.||||||||        ||| .|..||..|.||.
vllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlp

QTTLDFWKMIIQHKTSTILMLCNLSEDSK
.|  |||.|. ......|.||..| |. .
etvedFwrmlweqgvtvivmltelvelgr
0040438 (Phosphotyrosine protein) phosphatases II 900-1005 9.2e-29 96.1 In-house 17-124 (317) alignment 
Range on Protein: 900-1005
Range on HMM: 17-124/317.0
KTIYETQYQLIKRLTPKttAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSD----NDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTI
.|. . ... . .|..    |.. .  . ..|||    || |  ||.|.  .    .||||||||||...|..||..|.||..|. |||.|. ......|
ftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

LMLCNLSEDS
.||..| |..
vmLteleelg
0039614 (Phosphotyrosine protein) phosphatases II 896-1008 2.2e-28 95.0 In-house 27-142 (297) alignment 
Range on Protein: 896-1008
Range on HMM: 27-142/297.0
TKTKKTIYETQYQLIKRLTPKttaYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQ-----SDNDYINASYVDGYQK-KKEFIIAQSPLEQTTLDFWKMIIQ
....||....... ...|.|    |..      ..|||    || |  ||.|.       |.||||||||||| . ...||..| ||..|. |||.|. .
kansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

HKTSTILMLCNLSEDSKAC
.....|.||..| |... |
qgvtvivmLtklvelgrkc
0046845 (Phosphotyrosine protein) phosphatases II 905-1005 3.6e-28 94.2 In-house 4-115 (284) alignment 
Range on Protein: 905-1005
Range on HMM: 4-115/284.0
TQYQLIKRLTPKTT-AYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQ-----SDNDYINASYVDGY-----QKKKEFIIAQSPLEQTTLDFWKMIIQHKTS
 ... . .||.| .  ... .    ..|||    || |  ||.|.      .|.|||||||||||      .||.||..| ||..|. |||.|. .....
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

TILMLCNLSEDS
.| ||..| |..
vIVmltelveng
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 895-1008 4.2e-28 93.4 In-house 16-130 (305) alignment 
Range on Protein: 895-1008
Range on HMM: 16-130/305.0
DTKTKKTIYETQYQLIKRLtPKTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSDN--DYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKT
....... .|.||... .. ....  ...  .   ....  ..|. |  ..  ..|..  |||||||||||..||..|.||.||..|  |||..|.. |.
arvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekv

STILMLCNLSEDSKAC
|||.||..| |. | .
stivmltklveggkdk
DSPc_SM00195 904-1007 8.4e-28 92.8 In-house 3-110 (263) alignment 
Range on Protein: 904-1007
Range on HMM: 3-110/263.0
ETQYQLIKRLTPKTtAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSD----NDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLC
..... ... |...   ....     .||| .  ||.|  || |....    .|||||.|..|..|||..|..| ||..|  |||.|....|...|.||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLSEDS-KA
. .|.  . 
eeeengkek
PTPc_SM00194 904-1007 8.4e-28 92.8 In-house 3-110 (263) alignment 
Range on Protein: 904-1007
Range on HMM: 3-110/263.0
ETQYQLIKRLTPKTtAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSD----NDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLC
..... ... |...   ....     .||| .  ||.|  || |....    .|||||.|..|..|||..|..| ||..|  |||.|....|...|.||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLSEDS-KA
. .|.  . 
eeeengkek
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 875-1006 2.7e-27 90.8 In-house 1-138 (298) alignment 
Range on Protein: 875-1006
Range on HMM: 1-138/298.0
GNTLIPVAQFSEIIGNFDYTDTKTKKTIYETQYQLIKRLTPKTTAYKCEIGR--DFIEKNRPEVPLPIDTRRVVLQQ----SDNDYINASYVDGYQKKKE
||| | . .... . ..   . |.| | |....| ... . .  . . |..|  .  .|||    ...|  ||||..     . ||||||....|.... 
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
||..| ||..|. |||.|..... .|| || || |  |
fiatqaPltetvedFWrmvteedigtiVmltnleeldk
0043336 (Phosphotyrosine protein) phosphatases II 898-1006 3.2e-27 91.1 In-house 17-127 (278) alignment 
Range on Protein: 898-1006
Range on HMM: 17-127/278.0
TKKTIYETQYQLIKRLTPktTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSD----NDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTS
. ||... ... . . ..    |.. .  . ..|||    || |  ||.|.  .    .|||||||||||.....||..| ||..|. |||.|. .....
nlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvt

TILMLCNLSEDSK
||.||..| |...
tivmLtelvelgr
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 900-1004 6.1e-27 89.3 In-house 5-109 (267) alignment 
Range on Protein: 900-1004
Range on HMM: 5-109/267.0
KTIYETQYQLIKRLTPKTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLC
.. .| ...|||.......   . |. .  |.|| .  || |  ||.|......|||||||.||..|. ||. | ||..|  ||...|...| ..| .| 
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivllt

NLSED
.  .|
kvftd
Y_phosphatase Protein-tyrosine phosphatase 930-1008 1.8e-26 88.4 Pfam-A 3-84 (235) alignment 
Range on Protein: 930-1008
Range on HMM: 3-84/235.0
EKNRPEVPLPIDTRRVVL--QQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSED-SKAC
.||| .  ||.|  || |  .....|||||.||.||..||.||..| ||..|  |||.|..|.|...| ||..| |  ...|
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekc
Y_phosphatase Protein-tyrosine phosphatase 930-1008 1.8e-26 88.4 In-house 3-84 (235) alignment 
Range on Protein: 930-1008
Range on HMM: 3-84/235.0
EKNRPEVPLPIDTRRVVL--QQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSED-SKAC
.||| .  ||.|  || |  .....|||||.||.||..||.||..| ||..|  |||.|..|.|...| ||..| |  ...|
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekc
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 878-1006 2.2e-26 87.4 In-house 1-130 (290) alignment 
Range on Protein: 878-1006
Range on HMM: 1-130/290.0
LIPVAQFSEIIGnfdyTDTKTKKTIYETQYQLIKRlTPKTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQ----QSD--NDYINASYVDGYQKKKEFII
|||| .|.| .     ..... .. ...|.. ..  . .  . . ... .  ..|| .  .. |  |..|.    . |  |.||||.|..||..||..|.
lipvdkfgefva....nghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyia

AQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
.|.|...|  ||||.| |.|.. |.||.|  |. |
tqgpvsntlvdFWkliwqekvtiivmltniieegk
0048076 (Phosphotyrosine protein) phosphatases II 723-868 7e-26 86.0 In-house 2-139 (145) alignment 
Range on Protein: 723-868
Range on HMM: 2-139/145.0
YWPPSPDNELQFGPFVikVASEEEAYANFVIRSFEILLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKlGGPIVTHCSAGVGRTGTF
|||   .. | .|..   .|.. | .... |.    | .. .  .... ..... ||||||||  . |  |.. . ..... |||.. |||||||||||.
ywpseilpglylgslp..taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.ggpvlVHCsaGvgRtgtl

IALDIGLEqmksENqIDFIQIINQMRDQRMHMVQTINQFIFLHDTL
.|... |.    .. ... ......| ||...|.. .|..||.. .
vaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefe
subfamily_PTPRD_pd Subfamily PTPRD 930-1006 7.9e-26 85.8 In-house 50-130 (564) alignment 
Range on Protein: 930-1006
Range on HMM: 50-130/564.0
EKNRPEVPLPIDTRRVVLQ----QSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
.||| .  .. |. ||||.    ... ||||||..|||.|.|..| .| ||..|. |||.|. ....||| || .|.| .|
aKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 684-864 2.6e-25 83.5 In-house 97-280 (302) alignment 
Range on Protein: 684-864
Range on HMM: 97-280/302.0
QGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDNELQFGPFVIKVASEEEAYANFVIR-SFEI---LLTD---GTQAKHYVKHFQFT
  |  ||.   | .. | .  ..| |....|..  |  ||.    ..||.|| . .|  | ..  ..|  . || .    ...    .. |. |. ..|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPDHGVPDHGSPLVifmqKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFL
|||||| |..  . .    .....       .. |||||||||||..|.  |..  . ..  |...|.  .|. |   ||. .| |.|
awpdhGapkeaytal....dilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_PTPRG_pd Subfamily PTPRG 879-1006 3.2e-25 83.4 In-house 1-130 (563) alignment 
Range on Protein: 879-1006
Range on HMM: 1-130/563.0
IPVAQFSEIIGNFdYTDTktkKTIYETQYQ-LIKRLTPKTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSD----N-DYINASYVDGYQKKKEFIIA
.|| .|.. . .  ..|.   .. .. ... |... ..|.  ..    ..  .|||    ...|  || |..      . |||||.|.|||||.|.||..
vpvkefakhvasl.hadg...digfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiat

QSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
| ||..|. |||.|| ......| |. || |. .
qgplkdtfddFWrmiWeqnvaiivmitnlvergr
subfamily_CG7180_pd Subfamily CG7180 897-1008 9.6e-25 81.8 In-house 9-126 (296) alignment 
Range on Protein: 897-1008
Range on HMM: 9-126/296.0
KTKKTIYETQYQLIKRLTPKTTAYKCE--IGRDFIEKNRPEVPLPIDTRRVVLQQ----SDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQH
 .|.  .. .|.|. .|||. .  .|   .. . .||||    .| |  ||||..    ...|||||.|||.. ||||.|. . | ..|  .||... ..
vdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvyde

KTSTILMLCNLSEDSKAC
..|.. .|..  . .| .
eisavvvLtktfdfakmy
0048179 (Phosphotyrosine protein) phosphatases II 763-866 2.9e-24 80.8 In-house 42-139 (144) alignment 
Range on Protein: 763-866
Range on HMM: 42-139/144.0
GTQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAkLGGPIVTHCSAGVGRTGTFIALDigleQMKSENqIDFIQIINQMRDQRMHMVQTINQFI
 .  .... ..... ||||||||. . |  |.. . ....  |||.. |||||||||||..|..     || .. ... ......| .|...|.. .|..
pefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlr

FLHD
||..
fLle
0045098 (Phosphotyrosine protein) phosphatases II 920-1005 4.6e-24 80.7 In-house 25-102 (278) alignment 
Range on Protein: 920-1005
Range on HMM: 25-102/278.0
YKCEIGRDFIEKNRPEVPLPIDTRRVVlqqsdnDYINASYVDGYqkKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDS
. . . .. ..|||    ||.|  ||.      |||||||.|||  .|.||..| ||..|. |||.|. ......|.||..| |..
itpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 898-1006 8.9e-24 79.1 In-house 20-130 (319) alignment 
Range on Protein: 898-1006
Range on HMM: 20-130/319.0
TKKTIYETQYQLIKRLTPKtTAYKCEIgRDFIEKNRPEVPLPIDTRRVVLQQ----SDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTS
| .|  | ...|.|  ... | ....   .  .||| .  |..|  ||||..     . ||||||..||||....|| .|.|||.|. |||.|. ....|
tgetllekefkllkeavnd.tfdsask.eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

TILMLCNLSEDSK
...||..|.|  |
ivvmltklveklk
subfamily_CG42327_pd Subfamily CG42327 619-796 1.1e-23 78.5 In-house 17-189 (319) alignment 
Range on Protein: 619-796
Range on HMM: 17-189/319.0
LIRDTDhslSVANANRSKNRYKNIIPYDDNMIALQPIEgwDEFQGQYINASYINGYN-FKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNR
||  .|    |  . . |.|. |..|  .  . || |   |. . .|..|||. ||.  .| .||.| .| ... |.||..|. .| ||| ||.. |   
liarad...evPvtskdksrvinvvPlPetrvvlqrig..dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGi

VKSEEYWPPSP--DNELQFGPFVIKVASEeEAYANFVIRSFEILLTDGTQAKHyVKHFQFtAWPDHGVPDHGSPLVIFMQK
 .  ||.|..   ||.  .| . . .    |.  ...| .. .   |. .... . |. .  |.. .|| . ..|.  . .
kvcaeylPtketldntslyGdilvtlkgr.evkdryaistlllkrvdkeesre.lthywy.kwleaevPaeeaaliamlle
0040439 (Phosphotyrosine protein) phosphatases II 928-1004 1.5e-23 79.2 In-house 11-91 (249) alignment 
Range on Protein: 928-1004
Range on HMM: 11-91/249.0
FIEKNRPEVPLPIDTRRVVLQQ----SDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSED
 ..|||    || |  ||.|.      ..|||||||.|||. |..||..| ||..|. |||.|. ... ..|.||..| | 
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 900-1008 1.7e-23 77.9 In-house 5-117 (283) alignment 
Range on Protein: 900-1008
Range on HMM: 5-117/283.0
KTIYETQYQLIKRLTPKTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSDNDYINASYVD---GYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTIL
.. .. ... .|||.      ...  ..  .||| .  .| |  || |.   .|||||...     |...|..|||||||..|  |||||. ..| ..|.
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLCNLSEDSK-AC
|| .| || . .|
mltklqedlrikC
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 660-905 2.1e-23 77.9 In-house 43-281 (290) alignment 
Range on Protein: 660-905
Range on HMM: 43-281/290.0
EFQGQYINASYINgYNFKNKFIATQGPLS-------STTGDLWRMMWQERSHVIVMLTNVIEGNRVKSE----EYWPPSPDNELQFGPFVIKVaSEEEAY
 |. .|| |...  .    ..|.|| |.        ||  . | |. ||... .||| .. | .. .|.    .| | | ..||.|. . .|   . |. 
rfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.kskeke

ANFVIRSFEILLTDgtQAKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAklggPIVTHCSAGVGRTGTFIALDIGLEQMK-SENQIDFIQIINQM
 .. .|  ..   |  . .. |.| ..  | .  |...   |.  .|||. ...    |.. ||  |. |  .. |...|   .  ..... . ......
ddvetRelvvkfdd..eeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkal

RDQRMHMVQTINQFIFLHDTLLeqvlcgntlipvAQFSEIIGNFDYTDTKT-KKTIYET
| || ..... ... |    ..              . |.  .|   .|..  |. ...
rkqralaitsalelafvdagiv............llaievldqfaeeetekkakaeeke
subfamily_PTPN23_pd Subfamily PTPN23 899-1007 3.8e-23 76.7 In-house 13-123 (288) alignment 
Range on Protein: 899-1007
Range on HMM: 13-123/288.0
KKTIYETQYQLIKRLTP-KTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSDNDYINASYVDGYQK-KKEFIIAQSPLEQTTLDFWKMIIQHKTSTIL
 ||  .........    ..    . | . . |||| .  || |  ||.|..| .||||||.| .      .||..|.||..|  |||.|. . |.|.| 
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviV

MLCNLSEDSKA
|| . .|  | 
mllskeelgkp
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 930-1008 3.9e-23 76.9 In-house 11-93 (250) alignment 
Range on Protein: 930-1008
Range on HMM: 11-93/250.0
EKNRPEVPLPIDTRRVVLQQSD----NDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSKAC
||||    ...|  ||||....     ||||||...||...| ||..|.||..|. |||.|....|..||.|| ||.|  | .
eknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekty
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 897-1007 4.9e-23 76.3 In-house 11-125 (301) alignment 
Range on Protein: 897-1007
Range on HMM: 11-125/301.0
KTKKTIYETQYQLIKRLTPKTTAYKCEIGRDFIEKNRPEVPLpiDTRRVVLQQS------DNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQH
..... .| ||. .|. ..|..  ...  .  .....  ...  |  |..|..        ..||||||.|||..||.||.||.|...|  |||..|.|.
akhsnkfeeqykelkegedksctvglseenkalnrfknitvy..ddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

KTSTILMLCNLSEDSKA
|...|.|..|| |..|.
kpvsivmvtnlkegtks
subfamily_Ptp69D_pd Subfamily Ptp69D 904-1008 9.5e-23 75.8 In-house 25-133 (307) alignment 
Range on Protein: 904-1008
Range on HMM: 25-133/307.0
ETQYQLIK-RLTPKTTaYKCEIgRDFIEKNRPEVPLPIDTRRVVLQQ----SDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILML
.  |. .. | ..|.|    |   .   ||| |   . |  ||.|..     | ||||||.. ||..||.||.|| |.|.|  |||.|| . .  .| ||
akeyekLeareidkst.kvsek.kenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

CNLSEDSKA-C
 ||.| ... |
snlteknrkkc
0042113 (Phosphotyrosine protein) phosphatases II 928-1006 1.3e-22 75.8 In-house 9-91 (245) alignment 
Range on Protein: 928-1006
Range on HMM: 9-91/245.0
FIEKNRPEVPLPIDTRRVVLQQSD----NDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
 ..||| . .|| |  ||.|.  .    .|||||||||||. .. ||..| ||..|. |||.|. ... .||.||... |...
nkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgr
subfamily_PTPRB_pd Subfamily PTPRB 899-1006 1.5e-22 75.0 In-house 23-133 (293) alignment 
Range on Protein: 899-1006
Range on HMM: 23-133/293.0
KKTIYETQYQLIKRLTPKTTAYKCEIgRDFIEKNRPEVPLPIDTRRVVL----QQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTST
 .. .  .|. .| .  ...  . |      .||| .  || |. || |    ..|..|||||.|..||. ..||| .| || .|. |||.|. ..|.|.
sdlrfseeyeelkavgkdqavkaael.avnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

ILMLCNLSEDSK
|.|| .| |  |
ivmltqlvekgk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 900-1007 2.3e-22 74.4 In-house 20-131 (288) alignment 
Range on Protein: 900-1007
Range on HMM: 20-131/288.0
KTIYETQYQLIKRLTPKTTAYKCEIGRDfIEKNRPEVPLPIDTRRVVLQQ----SDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTI
.| .. .|. .  |  . .  . .  ..  .||| .  ||.| .|| |..    ...|||||||.||..|||..| .|.|| .|  |||... ..|||||
rtgfseeynsLaalektksvtagrlavn.akknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktsti

LMLCNLSEDSK-A
.|| .| |. |  
vmltelveggktk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 900-1007 2.8e-22 74.2 In-house 19-129 (318) alignment 
Range on Protein: 900-1007
Range on HMM: 19-129/318.0
KTIYETQYQLIKRLTPKTTAYKCeIGRDFIEKNRPEVPLPIDTRRVVLQQS----DNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTI
.. ....|. ..| . ..|..|  .      |||    |. |. || ||.     . |||||.|.|||..||..| ||.|| .|  |||.|. . ....|
elllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavi

LMLCNLSEDSKA
.|| ...| .||
vmltqeeergka
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 632-879 2.9e-22 73.6 In-house 46-285 (303) alignment 
Range on Protein: 632-879
Range on HMM: 46-285/303.0
ANRSKNRYKNIIPYDDNMIALQpiegwdefQGQYINASYINgYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDnE
 |  |||. ..|  |   . |         .  || |||..  . ..| | || ||| |. |.|.|. ... .....|    | ...  .  .|   |  
knmdknrfvdvicldhskvkls........dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.f

LQFGPFVIKVASEE--EAYANFVIRSfeiLLTDGTQAKHYVKHFQFTAWPDHGVPDHGSPLVI-FMQKVMHYHAK--LGGPIVTHCSAGVGRTGTFIALD
|.|   .|.|      |    .|..    |     . | ...  .. |||   .| .||| ..  . ..  .  |   . | |    .|.||.|||  ..
lkfeersirvgefkrvelgdgwvlkv...lsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfe

IGLEQMKSEN-QIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLcGNTLI
     ..||.  .|... ....|. |.| || . || ...  | |.|| .| ..
tahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl.dngic
subfamily_PTPRA_pd Subfamily PTPRA 928-1005 3.4e-22 73.7 In-house 58-139 (330) alignment 
Range on Protein: 928-1005
Range on HMM: 58-139/330.0
FIEKNRPEVPLPIDTRRVVLQQS----DNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDS
  ||||    || |  ||.|..     . ||||||..|||..|..|| || |.|.|  |||.|| ..|..||.|| .| |  
nkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 635-874 1.1e-21 71.9 In-house 45-278 (312) alignment 
Range on Protein: 635-874
Range on HMM: 45-278/312.0
SKNRYKNIIPYDDNMIALQpieGWDEFqgqYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSP-----D
  ||| ||  .|   ..|    | ..|   || | ...     ..|..||||| .|.  .|..     |  |..|. ..|    |. .|          .
dlnrypniqcwdrgrftla...gdenf...yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

NELQFGPFVIKVASEEEAYANFVIRSFEILLTDGTQaKHYVKHFQFTAWPDHGVPDHGSPLVIFMQKVmhyhAKLGGPIVTHCSAGVGRTGTFIALDIGL
.   .  .. ..     .  .   | . ...    | .  ..|.|...|||||.||       ..  |     |   |...|||||||||||.. ..  .
dhrvyteycteieiggkskdkithrvlkvvvkatgq.esklnhyqwaswpdhgmpdscdtalrllsav....kkdkkpviahcsagvgrtgtlaliesmi

EQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLC
  ..   . .  ..   .| .|   |... |...   ..|| . .
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_PTPN9_pd Subfamily PTPN9 892-1006 1.1e-21 72.1 In-house 8-124 (297) alignment 
Range on Protein: 892-1006
Range on HMM: 8-124/297.0
DYTDTKTKKTIYEtQYQLIKRLTPKTTAYKCEIgRDFIEKNRPEVPLPIDTRRVVLQQSD----NDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMI
.|   | |. ... .|. |.. ... |... .. |  .|||| .  | .|  ||||.. |     |||||..||||..|| || .| ||..|. |||.|.
ayvkekgkrGlsk.eyaeirnepveGtflaskl.ranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmv

IQHKTSTILMLCNLSEDSK
 .... .|.|   . |  .
Weqevlvivmttrvvergr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 915-1009 3.5e-21 70.4 In-house 29-130 (315) alignment 
Range on Protein: 915-1009
Range on HMM: 29-130/315.0
PKTTAYKCEIGRDF--IEKNRPEVPLPIDTRRVVL----QQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK-A
|   .|.  ..|.    .||| .  ||.|. ||.|    .. |.|||||||. .... | .| .| ||. .  |||.|..|.|..|| |. ...|. |  
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CA
|.
cr
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 690-874 4.5e-21 70.1 In-house 40-223 (255) alignment 
Range on Protein: 690-874
Range on HMM: 40-223/255.0
TTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDNELQFGPFVIKVASeeeAYANFVIRSFEILLTDG-TQAKHYVKHFQFTAWPDHGVPDHGS
|   ..... | ...|.|||..  | ...| ..|.|   |. |..    . ..    . |. |.|  ||..| |  .  | |||.... |...  |.   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

PLVIFMqKVMHYHaKlggPIVTHCSAGVGRTGTFIALDIGLEQM------KSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLC
 .   . ||..   |   ..| |||.|.||. .|.  ..   .|       .  ..|........| .|   ..|  |. |   ..|. |  
eilnil.kvvrds.k...svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfp
subfamily_PTPN12_pd Subfamily PTPN12 901-1006 7.4e-21 69.3 In-house 8-122 (290) alignment 
Range on Protein: 901-1006
Range on HMM: 8-122/290.0
TIYETQYQLIKRLTPKT---TAYKCEIGR--DFIEKNRPEVPLPIDTRRVVLQQS----DNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHK
  .....| .|.|. |    ..|. | |.    ..|||    || |. ||.|..     ..|||||... | ..|.|.| ||.|| .|  |||.||....
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

TSTILMLCNLSEDSK
.. ..|.|.. |  |
veivvmaCrevelgk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 677-865 8.5e-21 69.0 In-house 4-197 (199) alignment 
Range on Protein: 677-865
Range on HMM: 4-197/199.0
KNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDNELQFGPFVIKVASeEEAYANFVIRSfeILLTDGTQA---KHYVKHF
. ..|||| ||  |  |.|.|.|.  |  |||. .    . .    ||| .     ..| . . . .   . ....| .  ..||. | |      . |.
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkt.ittkpdytita..liltnnttappstreishy

QFTAWPDHGVPDHGS--PLVIFMQKV-MHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKS--ENQIDFIQIINQMRDQRMHMVQTINQFIFLH
|||.| ..  |.      .|.  ..|  .|  .   |.. ||| | | || |.|||||.   .      .|.... ...|. |  .. ..... |..
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 678-865 8.8e-21 69.0 In-house 4-196 (198) alignment 
Range on Protein: 678-865
Range on HMM: 4-196/198.0
NKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDNELQFGPFVIKVASeEEAYANFVIRSfeILLTDGTQA---KHYVKHFQ
 ..|||| ||  |  |.|.|.|.  |  |||. .    . .    ||| .     ..| . . . .   . ....| .  ..||. | |      . |.|
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkt.ittkpdytita..liltnnttappstreishyq

FTAWPDHGVPDHGS--PLVIFMQKV-MHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLEQMKS--ENQIDFIQIINQMRDQRMHMVQTINQFIFLH
||.| ..  |.      .|.  ..|  .|  .   |.. ||| | | || |.|||||.   .      .|.... ...|. |  .. ..... |..
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 624-746 3.4e-20 67.0 In-house 38-167 (350) alignment 
Range on Protein: 624-746
Range on HMM: 38-167/350.0
DHSLSVANANRSKNRYKNIIPYDDNMIALQ----PIEGWDE--FQGQYINASYINGY------NFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTN
|  ||      .|||||||.||. . . |.    . .. .       ||||.|..        | . |.||||.|| ||  | .... .   .||..||.
DvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

VIEGNRVKSEEYWppspdNELQFGPFVIKVASEEE
 .| |. | ..||     .|...  . .|.||  |
dvelnlekcyrYW.....qegsydditvklaskwe
subfamily_PTPRK_pd Subfamily PTPRK 929-1006 3.5e-20 67.0 In-house 44-125 (314) alignment 
Range on Protein: 929-1006
Range on HMM: 44-125/314.0
IEKNRPEVPLPIDTRRVVLQQSDND----YINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
 |||| .  |. |  ||.|.. |.|    ||||...|.|.. ..||..| ||..|. |||... ......|.|| .| | ..
reknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 928-1009 3.8e-20 67.2 In-house 51-134 (297) alignment 
Range on Protein: 928-1009
Range on HMM: 51-134/297.0
FIEKNRPEVPLPIDTRRVVLQQS----DNDYINASYVDGYQKkkEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSKACA
 .||.| .  ||.|. || |.      | ||.|||.| |...  ..|  | | ..|  |||.|......|||.|| ...|  | ||
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkca
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 895-999 4.3e-20 67.3 In-house 28-136 (319) alignment 
Range on Protein: 895-999
Range on HMM: 28-136/319.0
DTKTKKTIYETQYQLIKRLTPKTTAYK-CEIgRDFIEKNRPEVPLPIDTRRVVLQQSD----NDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQ
| . ..|..| ... . .|... .  . ...  .  .|||    |. |  .| |.. .     ||||||.|.|||.|. .| || ||. |  |||.|| .
dfdddltklevefrracklgvnladqtfanl.dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwe

HKTSTILMLC
...|||..| 
yncstivllt
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 631-868 6.6e-20 65.7 In-house 49-281 (302) alignment 
Range on Protein: 631-868
Range on HMM: 49-281/302.0
NANRSKNRYKNIIPYDDNMIALQpiegwdEFQGQYINASYINGYNFKNKFIATQGPLSSTT---GDLWRMMWQERSHVIVMLTNVIEGNRvKSEEYWPPS
 .| .||. ...  .|.|.. |.      . . .|.||| ..  ..... | .| | ....    . |||..||.   .|.|    | ..   .|..|  
kknlkknqsedvpildsnlvkle......aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

PDNELQFGPFVI---KVASEEEAYANFVIrsfEILLTDGTQAKhYVKHFQFTAWPDHGVPDHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIA
 .. ...| . .   || . ||.  ..||   |.|  . ...   ..   .| |... ||.. . |.  ..|| . ..|   ..|     |.|| |.|..
sgdykeygkmfvNnrkVekaeeektryvi...EvlPegcsnsv.lanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagaflt

LDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTL
| . .|.......    .|....| || ..|....|...|. .|
lavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 929-999 4.5e-19 64.0 In-house 26-100 (284) alignment 
Range on Protein: 929-999
Range on HMM: 26-100/284.0
IEKNRPEVPLPIDTRRVVLQQSD----NDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLC
 .|||    |. |  .| |.. .     ||||||.. |||.|. .| .| ||. |  |||.|| ....|||..| 
kdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt
0037934 (Phosphotyrosine protein) phosphatases II 929-1004 9.7e-19 63.3 In-house 11-85 (243) alignment 
Range on Protein: 929-1004
Range on HMM: 11-85/243.0
IEKNRPEVPLPIDTRRVVLqqSDNDYINASYVDGYqkkKEFIIAQSPLEQTTLD----FWKMIIQHKTSTILMLCNLSED
..|||    || |  ||.|  ...|||||......   . .|. | ||..|. |    ||.|. ......|.||..| | 
lsknrysdilpydhsrvkl..egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvEl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 769-869 1.9e-18 61.4 In-house 216-341 (350) alignment 
Range on Protein: 769-869
Range on HMM: 216-341/350.0
YVKHFQFTAWPDHGVPDHGSPLVIFMQ----------KVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLE------QM-KSENQ-------IDFI-QI
 | ..|.  |.| ..  .   ..  ..             |.. . . ||. |||||||||||...||  |.      .. |  ..        | | .|
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

INQMRDQRMHMVQTINQFIFLHDTLL
.|..| ||. |||...||||....||
vnelrkqrismvqnldqfifiYeall
subfamily_PTPN3_pd Subfamily PTPN3 905-1006 2.9e-18 60.8 In-house 19-123 (280) alignment 
Range on Protein: 905-1006
Range on HMM: 19-123/280.0
TQYQLIKRLTPKTTAYKCEIGRDfIEKNRPEVPLPIDTRRVVLQQSDNDYINASYVD----GYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCN
.|.. . |  |. .  ..   .. ..|||    || |. || |..|..|||||.||.    . .  . .|..| ||..|. |||.|. ..|.|.|.|| .
aqfeqlyrkkpglaisaarkpen.lsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmltt

LSEDSK
| |. .
lverGr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 913-1007 3.3e-18 60.7 In-house 38-132 (315) alignment 
Range on Protein: 913-1007
Range on HMM: 38-132/315.0
LTPKTTAYKCEigrdFIEKNRPEVPLPIDTRRVVL----QQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSKA
| |  .| | |      .|||    .. |  || |    .... ||.||...|||.||. .| ||.|. ..  |||... ... ..|.|| || |. | 
lhpldvakkie....nkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekr
subfamily_hpo-7_pd Subfamily hpo-7 689-874 3.7e-18 60.4 In-house 45-229 (263) alignment 
Range on Protein: 689-874
Range on HMM: 45-229/263.0
STTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWPPSPDNELQFGPFVIKVASEEEayaNFVIRSFEILLTDG-TQAKHYVKHFQFTAWPDHGVPDHg
 |   ..... | ...|.|||..  | ...| ..|.|   |. ...    . ..   .   . .... |.| | |  .  | |||.... |...  |   
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpel.

splVIFMQKVMHYHAKLgGPIVTHCSAGVGRTGTFIALDIGLEQM------KSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLC
    . . ....   ..  ..| |||.|.||.  |   ..   .|       |  ..|........| .|   ..|  |. |   ..|. || 
...areilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvln
subfamily_PTPN6_pd Subfamily PTPN6 891-1006 5.7e-18 59.9 In-house 16-137 (306) alignment 
Range on Protein: 891-1006
Range on HMM: 16-137/306.0
FDYTDTKTKKTIYETQYQLIKRLTPKTTAYKCEIGR-DFIEKNRPEVPLPIDTRRVVL---QQSDNDYINASYVDGY--QKKKEFIIAQSPLEQTTLDFW
.. ......|. .| ... ...   |..  . |  . .  |||| .  || |  ||.|   . ...|||||.|...   ...|..| .|  ||.|  |||
lekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

KMIIQHKTSTILMLCNLSEDSK
.|. | ..  |.|. .  | .|
rmvwqensrvivmttkevErgk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 917-1009 5.7e-18 60.1 In-house 37-133 (325) alignment 
Range on Protein: 917-1009
Range on HMM: 37-133/325.0
TTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQ----SDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSKACA
. |.|     . ..||| .  ...|  ||||.     .. |||||||.  ..||. |. ||.|| .|. |.|..... ..| ...|  | .. . ||
giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrca
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 927-1006 9.1e-18 58.8 In-house 44-127 (392) alignment 
Range on Protein: 927-1006
Range on HMM: 44-127/392.0
DFIEKNRPEVPLPIDTRRVVL----QQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
. ..||| .  ||.|. ||.|    . .|.||.||||..... .| .| .|.|   .  |||.|. |....|| |. .| |  |
inlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 900-1005 9.4e-18 59.3 In-house 14-122 (281) alignment 
Range on Protein: 900-1005
Range on HMM: 14-122/281.0
KTIYETQYQLIKRLTPKTTAYKCEiGRDFIEKNRPEVPLPIDTRRVVL----QQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTI
.. . ..|. .. .  . ||   .   . ..|||       |  ||..    .....|||||..|.||...||.|..|.|. ..  .||.|....| |.|
naGfieeyeklaaigvdntatask.adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

LMLCNLSEDS
 |. .  | .
vmvtreieag
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 892-1007 9.6e-18 58.8 In-house 16-134 (290) alignment 
Range on Protein: 892-1007
Range on HMM: 16-134/290.0
DYTDTKTKKTIYETQYQLIKRLTPK--TTAYKCEIGRDF--IEKNRPEVPLPIDTRRVVLQQ-SDNDYINASYVDGYqkKKEFIIAQSPLEQTTLDFWKM
 .. . .||.. |   . ...| |   .  .. .|      ..|||       |  ||.|..  | ||. | ||.|   |  ||..| .|..|..|.|.|
kfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrm

IIQHKTSTILMLCNLSEDSKA
..|.|...| |||.| || ||
vlqekvaaivmlceliedGka
subfamily_PTPN1_pd Subfamily PTPN1 918-1005 9.7e-18 58.9 In-house 20-109 (290) alignment 
Range on Protein: 918-1005
Range on HMM: 20-109/290.0
TAYKCEIGRDFIE--KNRPEVPLPIDTRRVVLQQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDS
. ....  ..  .  .||     | |  |..|...|||||||| |.  . |...|..| || .|.  ||.|. ..|. ...|| .. | .
sdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 929-1006 1.4e-17 58.4 In-house 39-119 (287) alignment 
Range on Protein: 929-1006
Range on HMM: 39-119/287.0
IEKNRPEVPLPIDTRRVVLQ---QSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
..|||    ||||  ||.|    .   ||||| || .|.....|| ||.|.  |  |||..............    |...
vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveear
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 930-1008 1.5e-17 58.6 In-house 30-115 (274) alignment 
Range on Protein: 930-1008
Range on HMM: 30-115/274.0
EKNRPEVPLPIDTRRVVL-----QQSDNDYINASYVDGYQKK-KEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK-AC
.||| .  || .. ||.|     ...| .|||| |. ||... | .. .| || .|  |||.|| |.... |.|| .|.|  .  |
tknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkC
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 932-1006 8e-17 56.1 In-house 24-103 (270) alignment 
Range on Protein: 932-1006
Range on HMM: 24-103/270.0
NRPEVPLPIDTRRVVLQQSDN----DYINASYVDGYQK-KKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
|| .  ||  . ||.|.. ..     |||| || |... ||..| |..||. |. .||.||...|...|.|. .| |. .
nRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 897-1005 1.1e-16 55.4 In-house 16-129 (439) alignment 
Range on Protein: 897-1005
Range on HMM: 16-129/439.0
KTKKTIYETQYQLIKRLTPKTTAYKCEIGRDFIE-KNRPEVPLPIDTRRVVLQQS----DNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHK
| |. |..  .. |.   |. ..  . . ... . ||| .   . |  ||.||.        |||| |..|| ..| .| .| | ..|| |||...|..|
knkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk

TSTILMLCNLSEDS
|.||.||.|| |  
tvtivmltnlvesy
I-set Immunoglobulin I-set domain 481-568 1.5e-16 51.9 Pfam-A 2-90 (90) alignment 
Range on Protein: 481-568
Range on HMM: 2-90/90.0
YVIEFPANTKAVEGETVHLLVQVSGQPEPTYTWTHQGEPLQSSSDDKVQIFS-DGTLVIRDIEQENAGQYNFSARNIGGVLNRVVILTV
 . . . .... |||.| | ..|.|.|||. .|...|..|.||.. ||.  . . ||.|...|....|.|.  |.|  |  .  . |.|
kftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 809-872 3.6e-16 53.3 In-house 2-65 (69) alignment 
Range on Protein: 809-872
Range on HMM: 2-65/69.0
VTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQV
| |||.| ||||||||. . . ..|||  .|    .. ||  |  ||   ...||.||.| | .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 809-873 3.9e-16 53.2 In-house 1-65 (69) alignment 
Range on Protein: 809-873
Range on HMM: 1-65/69.0
VTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVL
| |||.| ||||||||. . . ..|||  .|    .. ||  |  ||   |...|.||.| | . 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 924-1006 3.8e-15 50.7 In-house 37-121 (307) alignment 
Range on Protein: 924-1006
Range on HMM: 37-121/307.0
IGRDFIEKNRPEVPLPIDTRRVVLQQ--SDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
  .   .||| .    .|  |.|..      ||| | |.    | | || || |||.|  .|| |.||.|  ...|||.. | .|
afsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielak
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 931-1005 4e-15 50.3 In-house 51-126 (305) alignment 
Range on Protein: 931-1005
Range on HMM: 51-126/305.0
KNRPEVPLPIDTRRVVLQQS-DNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDS
|||      .|  || |. .   .|| | ||    . | || .|.|||.|  ||| | .|.|  .|.||||| |  
knrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekg
subfamily_eak_pd Subfamily eak 629-787 7e-15 49.2 In-house 44-198 (332) alignment 
Range on Protein: 629-787
Range on HMM: 44-198/332.0
VANANRSKNRYK---NIIPYDDNMIALQPIEgwdEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEGNRVKSEEYWP
. ...| ..  .   .|.||| ... | .       .  ||||| ..  .  .|.| |  .  .    .|.|. ...|  ||.| . .| .  ||. |.|
isetarleavnrnvvkivpydrylvrltssq...lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp

PSPDNELQFGPFVIKVASEeEAYANFVIRSFEILLTDGTqakHYVKHFQFTAWPDHGVPDHG
    .||.|| . ..  .     ...  | .|.   . |   | |.|...  | .  .|   
dktreelkfGildverkef.vkrniletrllelskGnet...hrvlhykvfGwtettlpkye
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 922-1006 1.2e-14 48.6 In-house 46-133 (310) alignment 
Range on Protein: 922-1006
Range on HMM: 46-133/310.0
CEIGRDFIEKNRPEVPLPIDTRRVVLQQ---SDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
 |  .... |||    .  || || |.      .||| | ||     .. || .| ||..| .|||.||.| .. .||.||. .|. .
yeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegr
subfamily_CG42327_pd Subfamily CG42327 804-869 2.6e-14 47.6 In-house 246-312 (319) alignment 
Range on Protein: 804-869
Range on HMM: 246-312/319.0
LGGPIVTHCSAGVGRTGTFIALDIGLEQMKSE-NQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLL
  ||.| ||| ||||||. || || .....   . .|  |.. ..| .| . |.|..|. |.. .| 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_PTPN14_pd Subfamily PTPN14 909-1007 2.9e-14 47.8 In-house 31-133 (300) alignment 
Range on Protein: 909-1007
Range on HMM: 31-133/300.0
LIKRLTPkTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQ---SDNDYINASYVDGY--QKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSE
 |..     . ...    .  |||| .  || .  || |.    ....||||| .      |....|.||.|||.|  |||.|. ..... |.|| .  |
ripkkre.dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeee

DSKA
| | 
dgke
0041856 (Phosphotyrosine protein) phosphatases II 930-1002 3.1e-14 48.4 In-house 3-69 (182) alignment 
Range on Protein: 930-1002
Range on HMM: 3-69/182.0
EKNRPEVPLPIDTRRvvlqqsDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLS
.||| .  ||.|  |      |.|||||....|... ..||..| || .|. ||..|. ... .||..|..  
dknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 938-1006 3.8e-14 47.5 In-house 13-84 (237) alignment 
Range on Protein: 938-1006
Range on HMM: 13-84/237.0
LPIDTRRVVLQQ--SDNDYINASYVDGYQK-KKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
   |  ||||.   |. |||||.|..|..   |..| || ||| .  |||.|. | | | |.||  | |  .
vaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegne
subfamily_PTPRN_pd Subfamily PTPRN 898-1007 6e-14 46.4 In-house 26-141 (297) alignment 
Range on Protein: 898-1007
Range on HMM: 26-141/297.0
TKKTIYETQYQLIKRLTPKTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQ----SDNDYINASYV-DGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKT
..|.  | ... ...   . .. .     ....||| .  || |  || |..    ...|||||| . |   ..  .| .|.|| .|  |||.|. .. .
knkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

STILMLCNLSED-SKA
  |..|..|.|.  |.
vvivnltrleeegvkq
subfamily_PTPN13_pd Subfamily PTPN13 904-1005 6.1e-14 46.9 In-house 14-115 (273) alignment 
Range on Protein: 904-1005
Range on HMM: 14-115/273.0
ETQYQLIKRLTPKTtayKCEIGRD--FIEKNRPEVPLPIDTRRVVLQQSDNdYINASYVDGYQKK--KEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLC
. ... .. | |.    .||.|..    .|||    ||.|  || |... . |||||..     |   |.|..| || .|. |||.|. . |.. | |. 
aeefkelrelkpld...tcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

NLSEDS
.  |. 
lekekg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 914-1004 9.7e-14 45.6 In-house 82-174 (244) alignment 
Range on Protein: 914-1004
Range on HMM: 82-174/244.0
TPKTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQS--DNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSED
 |  .  |  .  .   |||  . ||.|  || | ..   | |||||.|    .  |.|..| || .|..|||||... .   ...|  . |.
rpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 798-870 1.4e-13 44.9 In-house 258-342 (349) alignment 
Range on Protein: 798-870
Range on HMM: 258-342/349.0
MHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLE----QMKSENQI-------DFIQ-IINQMRDQRMHMVQTINQFIFLHDTLLE
......   ... ||||| ||||... ||. |.      .  |.|       | |. |.|..| ||. ||| ..|||.....||.
lyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 938-1004 2.3e-13 44.8 In-house 45-112 (285) alignment 
Range on Protein: 938-1004
Range on HMM: 45-112/285.0
LPIDTRRVVLQQSDNDYINASYVDGYQKK-KEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSED
  |.  ||||.. | ||| ||..    |    .| .| || .|  |||.|| | | . .|||| | | 
rcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeg
0043147 (Phosphotyrosine protein) phosphatases II 950-1003 3.1e-13 45.3 In-house 3-56 (172) alignment 
Range on Protein: 950-1003
Range on HMM: 3-56/172.0
SDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSE
...|||||||.|.| . ..||. | ||  |. |||.|. ... ..|..|..|  
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltelly
subfamily_CG42327_pd Subfamily CG42327 936-1009 3.7e-13 43.8 In-house 38-115 (319) alignment 
Range on Protein: 936-1009
Range on HMM: 38-115/319.0
VPLPiDTRRVVLQQSDN---DYINASYVDGYQKKK-EFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDS-KACA
|||| .|| |. ...|.    |..|||| ||.. .  .| || .||... |||... . .. .|. |..|||   | ||
vPlP.etrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvca
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 929-1006 5.9e-13 43.3 In-house 34-115 (297) alignment 
Range on Protein: 929-1006
Range on HMM: 34-115/297.0
IEKNRPEVPLPIDTRRVVLQQ--SDNDYINASYVDGYQKK--KEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
. |||    |  |. || |..  ...||||| ||   ...    .|.|| ||..|  |||... ..   .| |...| || .
lrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 931-1006 2.7e-12 40.9 In-house 58-135 (305) alignment 
Range on Protein: 931-1006
Range on HMM: 58-135/305.0
KNRP-EVPLPiDTRRVV-LQQSDNDYINASYVDG-YQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
|||  .||   |   |   . |  ||| | ||      .| || || ||.||  .|| |.||.|   |.|||.  |  |
knryqdvpcq.dqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 807-873 3.7e-12 40.7 In-house 230-296 (297) alignment 
Range on Protein: 807-873
Range on HMM: 230-296/297.0
PIVTHCSAGVGRTGTFIALDIGLEQMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVL
... ||||||||.|  .  |. |.... .   |   |....|.||  .|||..|| .|.|  |....
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkklk
subfamily_ptpA1_pd Subfamily ptpA1 929-1006 3.8e-12 40.7 In-house 48-128 (418) alignment 
Range on Protein: 929-1006
Range on HMM: 48-128/418.0
IEKNRPEVPLPIDTRRVVLQQ----SDNDYINASYVDGYQkKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
  |||    ||..  || |..      .||||| |.||    |.|| .| || .|  |||.|. . .   |.||   ||. .
tsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 624-741 5.7e-12 39.6 In-house 39-165 (349) alignment 
Range on Protein: 624-741
Range on HMM: 39-165/349.0
DHSLSVANANRSKNRYKNIIPYDDNMIAL----QPIEGWDEF--------QGQYINASYIN--GYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVML
|  ||      .|||||.|.||.   . |    .. .. ..           .|||| |..   .. ..|.|||| || ||  | ....  .. .... |
dvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL

TNVIEGNRVKSEEYWppspdNELQFGPFVIKV
..  | .  | . ||     .||..  . .|.
nddkelslekcdiyw.....qelsysnitvkl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 664-783 6.1e-12 39.7 In-house 123-235 (244) alignment 
Range on Protein: 664-783
Range on HMM: 123-235/244.0
QYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEgnrvkSEEYWPPSPDNELQFGPFVIKVAsEEEAYANFVIRSFEILlTDG
 |||||..       ..| || ||. |. |.|.|| .    |.|.|  | |      .|||| |   |       . .. . . . |     .||  .| 
tyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....edeywpdseplewyeeditvtlt.drdefknikasnleie.sdm

TQAKHYVKHFQFTAWPDHGV
 ...  .  || . ||  | 
neshqaltmfqisnwpsdgt
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 931-1006 6.2e-12 39.9 In-house 53-129 (301) alignment 
Range on Protein: 931-1006
Range on HMM: 53-129/301.0
KN-RPEVPLPIDTRRVVLQQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
|. .|.||   .|   |...     | | ...   . . ||..|.||..|. ||| |..|..  .| ||..  |. .
khryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekle
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 941-1007 8.5e-12 39.2 In-house 47-116 (332) alignment 
Range on Protein: 941-1007
Range on HMM: 47-116/332.0
DTRRVVL--QQSDNDYINASYVDGYQKKKEFIIAQSPLEQ-TTLDFWKMIIQHKTSTILMLCNLSEDSKA
|  || |  |.  .|. |||.|||| ||  .|.||.|... |   ||.|. ..| | ||.. .. |  | 
dhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 948-1006 1.1e-11 38.9 In-house 62-120 (281) alignment 
Range on Protein: 948-1006
Range on HMM: 62-120/281.0
QQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
..   ||| | |.     |. .|..| | ..|  |||.|| | .|..|.|||.. |  .
nknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnr
subfamily_egg_pd Subfamily egg 940-1008 2.1e-11 38.1 In-house 52-123 (307) alignment 
Range on Protein: 940-1008
Range on HMM: 52-123/307.0
IDTRRVVLQ----QSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLsEDSKAC
 |. || |.    |  .|.| | .|.|     |||.||.||  |  |||.|. | .   |.||     .|. |
kdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsr.keserc
0049772 (Phosphotyrosine protein) phosphatases II 929-1003 2.3e-11 39.5 In-house 47-153 (314) alignment 
Range on Protein: 929-1003
Range on HMM: 47-153/314.0
IEKNRPEVPLPIDTRRVV--LQQSDNDYINASYVDGYqkkKEFIIAQSPLEQTTLDF----------WKMII--QHKTSTILM-----------------
..|||    || |.|...  |  |. ||||||||||.   . ||..| ||| |  ||          |.|..  .... .| |                 
rdknryldilpadnrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAl

----LCNLSE
    |..|..
gKtpllildg
fn3 Fibronectin type III domain 274-360 2.8e-11 36.6 Pfam-A 9-83 (85) alignment 
Range on Protein: 274-360
Range on HMM: 9-83/85.0
ESVNSSSFTITWETVSccNASGETPSYHIILNSDDDDDdddtalynvtVLYNVTVSPDTTWYTFTGLKPQVIYSVTIRALNSFGSGP
..|.|.|.|..|.  .  . .|.  .| . . .... .          .  ..||...|| .|.|||||   |.....|.|  | ||
sevtstsltlsWsppk..dgggpitgYeveyrekggge..........ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 929-1003 5.6e-11 36.6 In-house 48-119 (303) alignment 
Range on Protein: 929-1003
Range on HMM: 48-119/303.0
IEKNRPEVPLPIDTRRVVLqqSDNDYINASYVDGYQkKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSE
..|||    . .|  .| |  ||  || |||..    .|  |..| || .|. |||.|||. |   .|.|   ||
mdknrfvdvicldhskvkl..sdssyihasylelds.skkailtqlplshtaadfwqmiieqkvkcvlllltdse
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 663-783 1.2e-10 35.8 In-house 13-126 (130) alignment 
Range on Protein: 663-783
Range on HMM: 13-126/130.0
GQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNVIEgnrvkSEEYWPPSPDNELqFGPFVIKVASEEEAYANFVIRSFEIlLTD
 .|||||..   .  .... || ||. |. |.|.|| .    |.|.|  | |      .|||| |   |  .   .|   .. . . |     .||   |
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePlew.yeediivtltdrdefknikasnlei.esd

GTQAKHYVKHFQFTAWPDHGV
  .... .  || . ||  | 
lneshqaltmfqisnwpsdgt
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 590-685 1.4e-10 35.2 In-house 3-95 (95) alignment 
Range on Protein: 590-685
Range on HMM: 3-95/95.0
KPIPADTLEKYVEMQHLSDNKPFNVLFSSLI--RDTDHSLSVANANRSKNRYKNIIPYDDNMIALQPiegwdEFQGQYINASYINGYNFKNKFIATQG
|||    .  .|   |   .. |.  | |.     . ..   ..||  |||. ||.|||   ..|         . .|||| ...||  || .||.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt.....krdsdyinacfvdgyarkncyiaaqg
0036282 (Phosphotyrosine protein) phosphatases II 952-1005 1.8e-10 36.3 In-house 2-50 (174) alignment 
Range on Protein: 952-1005
Range on HMM: 2-50/174.0
NDYINASYVDGYQKKKEFIIAQSPLEqttldFWKMIIQHKTSTILMLCNLSEDS
.||||||..|..   ...|. | ||.     ||.|. ... .|..||... |. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 930-1004 1.9e-10 35.0 In-house 49-141 (350) alignment 
Range on Protein: 930-1004
Range on HMM: 49-141/350.0
EKNRPEVPLPIDTRRVVLQ------------QSDNDYINASYVDGY----QKKKEF--IIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSED
 ||| .  || .  || |.             | ||||||.|.       . . .|  | .|.|| .|  ||.|.|.. |   ||.| .. | 
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel
0051429 (Phosphotyrosine protein) phosphatases II 952-1005 1.9e-10 36.4 In-house 4-59 (272) alignment 
Range on Protein: 952-1005
Range on HMM: 4-59/272.0
NDYINASYVDGYQK---KKEFIIAQSPLEQTTLDFWKMiIQHKTSTILMLCNLSEDS
..||||..|.|| .   .. .. .. ||. |  |||..  ... .||..|....|  
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 959-1004 2.8e-10 34.1 In-house 228-273 (440) alignment 
Range on Protein: 959-1004
Range on HMM: 228-273/440.0
YVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSED
 ..|| ||. || .| ||. | ||||... ... |||.|| .| . 
efegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 940-1006 3.4e-10 34.4 In-house 55-121 (288) alignment 
Range on Protein: 940-1006
Range on HMM: 55-121/288.0
IDTRRVVLQQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
 |. || |.   . ||.|  |   . |. .| ||.||. |   .|||...     |.|||.| |  |
cditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGk
subfamily_PTPDC1_pd Subfamily PTPDC1 771-866 4.7e-10 34.2 In-house 84-170 (182) alignment 
Range on Protein: 771-866
Range on HMM: 84-170/182.0
KHFQFtAWPDHGVPDHGSplVIFMQKVMHYHAKLGgPIVTHCSAGVGRTGTFIALDIgleqmKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHD
 ...| .|.|.||.   .  .. . ||...  . |  .  || || ||||  ||  .        ....  . |. .|..| . .|| .|  ....
yvynf.gwkDygvasler..iLdivkvvafalqeg.kvavhChaGlGrtGvliacyl.....vyakrltaekaiklvrskrpksiqtreqvelvke
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 938-1004 5e-10 33.8 In-house 3-65 (130) alignment 
Range on Protein: 938-1004
Range on HMM: 3-65/130.0
LPIDTRRVVlqqsDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSED
|. .  |.     .|.|||||.|   .. .|.. .| || .|..|||||...     ...|  . |.
lefevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 672-745 7.9e-10 32.6 In-house 230-299 (440) alignment 
Range on Protein: 672-745
Range on HMM: 230-299/440.0
NGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTNViegNRVKSEEYWPPSpDNELQFGPFVIKVASEE
.||  || ||||| || ||  |.||.. . |   |.|| ..   |      |||      . |||| .     |
egyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvn.trsvtfgpftvghkgse
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 938-1006 1.1e-09 32.8 In-house 18-91 (239) alignment 
Range on Protein: 938-1006
Range on HMM: 18-91/239.0
LPIDTRRVVLQQSDN----DYINASYVDGYQK-KKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
.  |  ||||..  |    |||||||.  |.   | .| .|  .| .. |||.|. | .   |.||  | |  |
vtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 938-1006 1.1e-09 32.8 In-house 17-90 (239) alignment 
Range on Protein: 938-1006
Range on HMM: 17-90/239.0
LPIDTRRVVLQQSDN----DYINASYVDGYQK-KKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
.  |  ||||..  |    |||||||.  |.   | .| .|  .| .. |||.|. | .   |.||  | |  |
vtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk
0046846 (Phosphotyrosine protein) phosphatases II 948-1005 1.2e-09 33.6 In-house 8-61 (176) alignment 
Range on Protein: 948-1005
Range on HMM: 8-61/176.0
QQSDNDYINASYVDGYQkkkeFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDS
 . | |||||....|.     .|. | ||..|. ||..|. ... .....|... | .
ldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelg
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 939-1006 1.3e-09 32.2 In-house 54-121 (312) alignment 
Range on Protein: 939-1006
Range on HMM: 54-121/312.0
PIDTRRVVLQQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
  |  |  |   .| || | .|    | . |...|.|||.|.  ||.. .   ...|..|| . ||. 
cwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgs
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 906-1000 1.4e-09 31.8 In-house 31-126 (302) alignment 
Range on Protein: 906-1000
Range on HMM: 31-126/302.0
QYQLIKrlTPKTTAYKCEIGRDFIEKNRPEVPLPIDTRRVVLQQSDNDYINASYVDGYQKKKEFIIAQSPLEQTT---LDFWKMIIQHKTSTILMLCN
... |.  | |. . ||.. .. ..||. |    .|...| |... ..|.||| |.  . ... |.|| |  ...    .||.|. |.|  .. .|  
efkkid..tmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvg
FHA FHA domain 99-158 4.6e-09 22.8 Pfam-A 8-68 (68) alignment 
Range on Protein: 99-158
Range on HMM: 8-68/68.0
ENDISFKSESIANFHCKITLLDYgESVYLHKLD--GLSFVNQIPVEQDDPVKLSHSDTLKLG
..|| ....||   |. |.  .   .|||. |.     |||. ......||.|.. |...||
dcdivlddpsiSrkHaeikydeg.gkvylrDlgSknGtfvNgqrigkgepvrLksgdvielg
0049260 (Phosphotyrosine protein) phosphatases II 959-1006 4.7e-09 31.6 In-house 1-48 (152) alignment 
Range on Protein: 959-1006
Range on HMM: 1-48/152.0
YVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSEDSK
..||| ...|||..| |...|. |||.|. ... .||.||..|.|. |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgk
0038934 (Phosphotyrosine protein) phosphatases II 776-865 1e-08 30.5 In-house 85-170 (194) alignment 
Range on Protein: 776-865
Range on HMM: 85-170/194.0
TAWPDHGVPDHGSPLVIFMQKVMHYHAK-LGGPIVTHCSAGVGRTGTFIALDIgleqMKSeNQIDFIQIINQMRDQRMHMVQTINQFIFLH
  .||.|..   . |  |.. | .....  || .. || ||.|||||..|  .    ... ....  . |. .|. | .........  |.
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL....iyr.lgmsaeeAialfrekRpgaipnqdyleall
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 919-973 1.2e-08 29.0 In-house 39-94 (95) alignment 
Range on Protein: 919-973
Range on HMM: 39-94/95.0
AYKCEIGRDFIEKNRPEVPLPIDTRRVVLQ-QSDNDYINASYVDGYQKKKEFIIAQ
.| .      | |||    .| |. ||||  . | ||||| .|||| .|. .| ||
pytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 632-711 2.2e-08 28.0 In-house 36-118 (347) alignment 
Range on Protein: 632-711
Range on HMM: 36-118/347.0
ANRSKNRYKNIIPYDDNMIALQPIEG---WDEFQGQYINASYINGYNFKNKFIATQGPLSSTTGDLWRMMWQERSHVIVMLTN
 . |||| |.    |.  . | | .      .    |||||.|.  | ....| || || .|  |.|.|.   .   .| . .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 949-1000 2.2e-08 28.0 In-house 67-118 (347) alignment 
Range on Protein: 949-1000
Range on HMM: 67-118/347.0
QSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCN
.  . |||||..   . .||.|..| || .|  |||||.   | . .. . .
ddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
Ig_2 Immunoglobulin domain 488-568 7.8e-08 24.2 Pfam-A 8-80 (80) alignment 
Range on Protein: 488-568
Range on HMM: 8-80/80.0
NTKAVEGETVHLLVQVSGQPEPTYTWTHQGEPLQSSSDDkvqifsdgtLVIRDIEQENAGQYNFSARN-IGGVLNRVVILTV
.| . |||.| |  |..| |.|...|...||.| .| .          | |. .. |..|.|  .|.|  |.  .. | .||
ptvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna.........lfipnvsaedsGtYtCrasnsegskqsnsvevtv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 931-1006 9e-08 26.6 In-house 22-106 (290) alignment 
Range on Protein: 931-1006
Range on HMM: 22-106/290.0
KNRPEVPLPIDTRrVVLQ----QSDNDYINASYVDgYQKKKEFIIAQSPLEQT-------TLDFWKMIIQHKTSTILMLCNLSEDSK
..| ||||  .|| |||.    .  .||| |..|  . .  ..|. |||.|..         .|| |. | |   . |||. .| |.
dqRlevpLveatr.vvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksa
0051082 (Phosphotyrosine protein) phosphatases II 952-1005 9.7e-08 27.3 In-house 3-47 (151) alignment 
Range on Protein: 952-1005
Range on HMM: 3-47/151.0
NDYINASYVDGYqkkkeFIIAQSPLEqttlDFWKMIIQHKTSTILMLCNLSEDS
.||||.|||.|.     ... . ||.    ||.... ... .||..|... |  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 598-674 3.3e-07 24.0 In-house 12-86 (440) alignment 
Range on Protein: 598-674
Range on HMM: 12-86/440.0
EKYVEMQHLSDNK--PFNVLFSSLIRDTDHSlSVANaNRSKNRYKNIIPYDDNMIALQPIEGWDefQGQYINASYINGY
  ||. .. |      ...| |.| . .| . |. | |. ||||.||. || . . |. ..|    . .||||||||| 
adyvqnnrrsrafedewsllpsglsqpsdia.slpn.nkvknryrnilaydhsrvmleevkgvp..dsdyinasyingi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 633-719 3.5e-07 24.0 In-house 34-117 (332) alignment 
Range on Protein: 633-719
Range on HMM: 34-117/332.0
NRSKNRYKNIIPYDDNMIALQPIEGWDEFqgqyINASYINGYNFKNKFIATQGPLSSTTGD-LWRMMWQERSHVIVMLTNVIEGNRVK
|   ||   .  .| . . | | .| |.|     |||...||. |. .| .| |.   |   .|||. . .  .|... .. | .. |
nmdmnriphlycfdhsrvelapqdgkddf....ynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 951-1003 1.8e-06 21.5 In-house 89-143 (349) alignment 
Range on Protein: 951-1003
Range on HMM: 89-143/349.0
DNDYINASYVDG--YQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNLSE
 .||||| |.    .. .| .|  | ||  |  ||.|.|.  .   .| | .  |
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 935-1000 2.3e-06 19.4 In-house 51-114 (327) alignment 
Range on Protein: 935-1000
Range on HMM: 51-114/327.0
EVPLPIDTRRVVLQQSDNDYINASYVDgyQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCN
 .|.||   | ||  ||....   ||    .  |.|| |.| ....   |..|.. .   .. || 
rlpipirdnrrvlcgsdeeffpgqyvr..megaeyiivqaptkksskliwrvilkdhirilvclch
0048567 (Phosphotyrosine protein) phosphatases II 775-832 2.8e-06 21.8 In-house 33-105 (157) alignment 
Range on Protein: 775-832
Range on HMM: 33-105/157.0
F---------TAWPDHGvPDHGSPLVIFMQKVMHYH---AKLGGPIVTHCSAGV---GRTGTFIAL-DIGLEQM
|         . . |.| | . . |. |..|....     . |..|. ||.||    |||.|.|..  |   ..
FsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf
subfamily_CDC14_pd Subfamily CDC14 785-843 3.9e-06 20.9 In-house 243-302 (328) alignment 
Range on Protein: 785-843
Range on HMM: 243-302/328.0
DHGSPLVIFMQKVMHYHAKLGGPIVTHCSAGVGRTGTFIALDIGLE-QMKSENQIDFIQI
| . |    ..| ..   |  | |. || ||.|||||.||  .  . .. ... | ...|
DGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlri
0044763 (Phosphotyrosine protein) phosphatases II 941-1003 5.9e-06 21.6 In-house 3-60 (178) alignment 
Range on Protein: 941-1003
Range on HMM: 3-60/178.0
DTRRVVLQQSDN----DYINASYVDGYqkkkeFIIAQSPLeqttLDFWKMIIQHKTSTILMLCNLSE
|  ||.|.   .    ||||||.....     ..... |      |..... ... ..|..|..  |
drtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteele
subfamily_eak_pd Subfamily eak 793-874 7.4e-06 19.6 In-house 226-307 (332) alignment 
Range on Protein: 793-874
Range on HMM: 226-307/332.0
FMQKVMHYHAKlGGPIVtHCSAGVGRTGTFIALDIGLE--QMKSENQIDFIQIINQMRDQRMHMVQTINQFIFLHDTLLEQVLC
...| .|       ||.  .. |  |.|.|. .|. ..  . | .|     ..| .....|.| | .  |  |... .|. .| 
tlkkyihtpps.fapii.qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_eak_pd Subfamily eak 947-1001 8.4e-06 19.4 In-house 70-127 (332) alignment 
Range on Protein: 947-1001
Range on HMM: 70-127/332.0
L---QQSDNDYINASYVDGYQKKKEFIIAQSPLEQTTLDFWKMIIQHKTSTILMLCNL
|   |.  . ||||| ..  .  ...|..  . |.    ||.|... |. .|..| . 
ltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlled