Gene PTPRD-76 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP135_AA protein Get Run
AqueP135_AA_2914-3191 phosphatase_domain Get Run
AqueP135_AA_3204-3484 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 2912-3237 4.6e-139 459.6 In-house 5-327 (564) alignment
Range on Protein: 2912-3237
Range on HMM: 5-327/564.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
..| ....|||...||.|. |. || ..|.... |..| ..| |  ||||||| |||||||.|.. ....|||||||..||||.|..||||.|||....|
ipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti

VDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPdKrVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRF
 |||||.|||...|.||||.|||||. ||| |||   .    .|.. ..|.||  |.||.||||.|..| ||. |...|.||||||| ||||..|.||..
edFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl

IHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLNE
|.||.. |...|||.|||||||||||||||.|.. ...| . | .|||..|. .|  | .||||| ||||||.|.||.|.||.|||.....|.... |.|
irkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLae

VfDKEEGKTRLEKEFDNIQETIHREP
| ..... | ||.||.... . . |.
v.eedtemtgleleFqrLatakeiel

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2912-3228 1.6e-123 406.8 In-house 2-317 (318) alignment
Range on Protein: 2912-3228
Range on HMM: 2-317/318.0
VSVGDFPAHVANMHANDDYLFSVEYPTV-EPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHS
.|| |.  ||...... . |.| ||  .   ....|.  . .| |. ||||||| ||||.||||..  ...|||||||||||||....||||.|.|.|. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

IVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLR
| |||||.|||.. ..||||..||.|..|.| |||  .|    .|.....|.||..|.||..|.|..... ....|...|||.||||| ||||....|| 
ieDfWrmvWeqnsavivmltqeeergkakvhryWP..skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslld

FIHKVQREN-PKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLL
.. .|.. . ...|||.||||||||||||.||... ....| . . .|....|. .| .|  ||||| ||.||.|.|||.|..|.|||.|...... | |
lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirel

NEVfDKEEGKTRLEKEFDN
.|. | | |.|... ||..
req.dpesgttemdaefqr

subfamily_PTPRD_pd Subfamily PTPRD 3245-3490 2.7e-108 358.1 In-house 46-288 (564) alignment
Range on Protein: 3245-3490
Range on HMM: 46-288/564.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMY
. |..||||||....|..| .||...|..|||||||.||.||.| ||.|||||||..| .||||||||..||||.|| . .| ||  ||||||..||. |
paNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtety

GFFEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQrNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
| ...||.. .|. ||..|.||.  ..  . .|. |.||...|||..|||.|| .|||....|.... ... .||||||| | |||||.|.   ...|.|
geltVtleeeeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerik

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYA
.|..||..|.|. || ||. || . .|| |... |||.| ...|  
eektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntev

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 3216-3491 9.4e-108 355.0 In-house 16-288 (318) alignment
Range on Protein: 3216-3491
Range on HMM: 16-288/318.0
EEGKTRLEKEFDNIQETiHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKS
|.|.. |..|..... . ....  .  . . |..||||||....|.|| ||... |. ||||||||.|.||.. ||.||.|.|||.| .|||||||| .|
esGelllseeyerlsrs.eetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqns

STIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDsrDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSG
..|.||..|.| ||| .|.|||..|.. ||   ..|.. .|. ||.|||||.    . | .|..|.|..| ||| .|||.|. .|||.  ||.|.|..||
avivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg

DKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYAN
 .|||||||.| ||||..||   |..|.| |.||||||.|. || ||. ||.  |||||.|. .||.| |.||...
agpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd

subfamily_PTPRG_pd Subfamily PTPRG 2912-3204 9.5e-106 349.2 In-house 1-301 (563) alignment
Range on Protein: 2912-3204
Range on HMM: 1-301/563.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPT---KDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGS-DYINANYIDGYKKENAYIASQGPV
| | .|  |||..||..|  || |.  .. .. ..    ...|.|.|  |||| || |||.|||||.. |.. .. |||||||||||.|..|.||.|||.
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQH---KVSS---DERTIKQYHFTSWPDFGV
.. . |||||||||.....||.|||.|.|| ||. |||     ..  |.....|.||  |. ||.||.....   |  .   .|....|||.|.||| ||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgv

PEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSARE
|||..  | |..| .. |...|||.|||||||||||||.| ..  ..|| ...  ....|.. .| .| |.|||| ||||.|||||| .  .|||..| .
PehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq

VKE
|.|
vee

subfamily_PTPRB_pd Subfamily PTPRB 2911-3194 2.9e-105 346.5 In-house 6-289 (293) alignment
Range on Protein: 2911-3194
Range on HMM: 6-289/293.0
YVSVGDFPAHVANMHANDDYLFSVEYPTVEPQ-HHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPH
 ... .| .||..|.|..|. || || ...   .. ...|.... |. |||| || .||||||||..  . .||||||||||.||. .. .||.|||.|.
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

SIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHkvSSDERTIKQYHFTSWPDFGVPEHPTTLL
.. |||||.||.|....||||.| |||..||. |||  |.. |..|.|...|..| .|.|..||......  ...||...|||||||||.||||...|||
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa.deepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktll

RFIHKVQREN--PKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGE
.|...|...    ....|.|||||||||||||||..   .|.| .. ..||. .|...| .|...||||.||||||...|..|. .|
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2913-3226 3.4e-103 340.1 In-house 6-318 (319) alignment
Range on Protein: 2913-3226
Range on HMM: 6-318/319.0
SVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIV
 | ..  .. ..... . |.  |. ...     | | .....|  |||| || |||..||.|.| ..|.|||||||..||||......|| |.|. . | 
evqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentie

DFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSD-ERTIKQYHFTSWPDFGVPEHPTTLLRF
|||||.||... .|||||.| ||...|.. |||  .. ... |.. ..|.||  | || || ..|..| |    |..|....|.||| .|||. |.|| .
dfWrmvWeeessivvmltklveklkvklkkywp..eenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

IHKVQRENPK-NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLN
......   | ..||.|||||||||||||||...  ....     ||....|. .|  | .|||...||.||..||||..|.|.||.  ........ |.
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

EVfDKEEGKTRLEKEF
|  . . |.| ||.||
ek.vadtgetgleref

0051299 (Phosphotyrosine protein) phosphatases II 2911-3190 5.1e-102 336.4 In-house 4-286 (288) alignment
Range on Protein: 2911-3190
Range on HMM: 4-286/288.0
YVSVGDFPAHVANMHANDDYLFSVEYPTVEPQH-HPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPH
 .|| ..  .| ...||. ...  |. .. ..  ..|  |...| |  |||| .| .||||||||.  ..|.|||||||.|||||......|| ||| |.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

SIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHK----VSSDERTIKQYHFTSWPDFGVPEHP
.. |||||.|||.....||||.|.|.||.||. |||.  . ....|.|.. | .| .| |||.||. ....     .. .||....|.|.|||.|||..|
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
. ||.|...|.. .... ||||||||||||||||||.. . ..|.. ....|....|. .| .|..||||. ||.|...||||||
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0040438 (Phosphotyrosine protein) phosphatases II 2914-3206 8e-102 336.0 In-house 2-292 (317) alignment
Range on Protein: 2914-3206
Range on HMM: 2-292/317.0
VGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVD
| |.. ..  ....| .... |. ..  ....| . ...|.|  |||| .|  ||||||||. ......||||||.|.||... ...|| ||| |... |
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIH
||||.|||.....||||.|||.||.||. |||   . ....|.....|..|  | ..|.||. .... .|..||....|.|.|||.|||..|..||.|..
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

KVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQF
.|.. .... |||.||||||||||||||.. . ..|.  ....|... |. .| .|. .|||..||.|..||||||| ...| ..| | |  .
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkl

subfamily_PTPRA_pd Subfamily PTPRA 2918-3225 1.2e-99 328.3 In-house 20-329 (330) alignment
Range on Protein: 2918-3225
Range on HMM: 20-329/330.0
PAHVANMHANDDYLFSVEYPTVEP-QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWR
   .    |.|  ||  |. ..   . . | ..... .|  |||. ||  ||.||| |..   |. |||||| .|||||. . .||.|||  ... ||||
eeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwr

MIWEQKTETVVMLTNLEEKGRIKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQH----KVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFI
||||||. |.||||.|.|. . ||. |||  |. .| .|.||.....|  | |||.| | .|.    .   ..| ..|.|||||||.||| .|  .|...
miweqksativmltelkerkeekcaqywP..deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkll

HKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLNEV
.||.. |...|||.|||||||||||||||...  ....   . .|...||...| .|. ||||. || ||. .||||   |.||. .  ...... | . 
kkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynk

FDKEeGKTRLEKE
  .   |. ||.|
itgt.dkigleee

0050432 (Phosphotyrosine protein) phosphatases II 2923-3195 5.6e-99 326.6 In-house 37-304 (308) alignment
Range on Protein: 2923-3195
Range on HMM: 37-304/308.0
NmhANDDYLFSVEYPTVEPQHH-PTKDATQHPDNAIKNRYANISAYDHSRVKLtedpNvPGSDYINANYIDGY--KKENAYIASQGPVPHSIVDFWRMIW
.  |.| .|.. |. ..  .   .. .....|.|  |||| .| .||||||||    . .|||||||.|.|||  |.....|| ||| |... |||||.|
k..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

EQKTETVVMLTNLEEKGRIKCHLYWPPPDK-RVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRE
||.....||||.|.|.||.||. |||.  .  ....|.... | .| .| |||.||. |... ....||....|.|.|||.|||..|. ||.|...|.. 
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

NPKnaGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGET
.|.  ||.|||||||||||||||.. . ..|.   ...|... |. .| .|..||||. ||.|...||||||.. .|
lpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 3193-3490 6.7e-97 319.3 In-house 1-297 (298) alignment
Range on Protein: 3193-3490
Range on HMM: 1-297/298.0
GETEVSAREVKEQFRLLNEVfDKEEGKTRLEKEFDNIQETIH--REPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGK
|.||..|...|.... |..| .|... |....|| ..... .  .|     . .. |..|||||..|..|..|  |... . . |||||| |...|.. .
gnteieaedlkaalqklaav.kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn

AFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAegSSQHVKQFQYVSWPS
||||||.||. |  ||||||.|....||.|| | .| .|  .||||||.|.. || ....|.| .|. |.| |..|. ... .  ....|.|....|||.
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpd

KGVPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYA
||||  |  .||....|...|...|.||..|.|| | ||.||.||   ...|.|.|  |||||||. || .|||.|.. .|| |.|. .||.| ||....
kgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei





0051299 (Phosphotyrosine protein) phosphatases II 3204-3483 1.6e-96 318.4 In-house 12-286 (288) alignment
Range on Protein: 3204-3483
Range on HMM: 12-286/288.0
EQFRLLNevfdkEEGKTRLEKEFDNIQETIHRePIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTS
. .. |        |.|.|..||. ... ..  . . ..    |..|||| ...|.|..| |||...||.|||||||..|.||.....|||||||||.| 
klvlkll.....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntv

DDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDS--RDAEGSSQHVKQFQYVSWPSKGVPDSAIGLL
.||||||||.....|.|| .. | |.  |..|||..|...|| . .|| |.....||..|......    | .| |..|..|.| .||  |||||.  ||
edFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspelll

DVREQVEKWQRnSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|  ..| |... ||..|.||||| |.|||||.||  ||...|..|| |||...|. || |||||| ...||.|.|. .||.|
dflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 3215-3488 1.8e-96 318.0 In-house 18-288 (319) alignment
Range on Protein: 3215-3488
Range on HMM: 18-288/319.0
KEEGKTRLEKEFDNIQETIHRepIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHK
.. |.| ||||| ...|.      . . .   |..|||| |....|.|| .||...||.|||||||.||.||.. ..|||||.|| .| .||||||||..
astgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeee

SSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIvDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNS
||...||..  | .|  ..||||.   . || . .|| . .|  ||| |..|. . . .|  . .||.||| .|| ..||..| .|||. ....| ....
ssivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt

GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDT
 ..||||||| | |||||.|.    ..|.| ||..|||..|. ||.||. ||.  .||.|.|. .||.. ..||
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt

0046845 (Phosphotyrosine protein) phosphatases II 2939-3195 3.7e-96 317.1 In-house 12-279 (284) alignment
Range on Protein: 2939-3195
Range on HMM: 12-279/284.0
VEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNV-PGSDYINANYIDGY-----KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNL
. . .. . .....| |  |||| .| .||||||||.  ..  ..||||||.|.|||     ......|| |||.|... |||||.|||.....||||.|
ltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltel

EEKGRIKCHLYWPPPdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKV-SSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENP--KNAGPVVVH
.|.||.||. |||.  . |...|.... | .|    |||.||..|...  .. .||....|.|||||.|||..|. ||.|...|.. ..  .. ||.|||
vengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVH

CSAGVGRTGTFITISCQIQQILDRK---CLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGET
||||||||||||.. . ..|.  ..   ..|... |. .| .|..||||..||.|...|||||| .. |
CsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

0036941 (Phosphotyrosine protein) phosphatases II 2941-3200 1.1e-95 315.6 In-house 24-287 (297) alignment
Range on Protein: 2941-3200
Range on HMM: 24-287/297.0
P-QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLtedpNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIK
| .. ....... |.|  |||| .| .|||.||||    . .|||||||.|.|||. ....|| ||| |... |||||.|||.....||||.|.|.||.|
pllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrek

CHLYWPPPDKRVVVHGQIRIQLQEELS--LTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK--NAGPVVVHCSAGVG
|. |||.    ....|.....|... .  |.|||.||. .... ....||....|.|.|||.||||.|..||.||..|.. ...  . |||.||||||||
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvg

RTGTFITISCQIQQIL---DRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAR
|.||||.. . .||.     ....||...|...| .|...|||. ||.|...||||.| ...| ....
RsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll

0043336 (Phosphotyrosine protein) phosphatases II 2912-3190 2.1e-95 314.6 In-house 2-277 (278) alignment
Range on Protein: 2912-3190
Range on HMM: 2-277/278.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
.|| |.. .......|. .|.. |. ..  ....|.. ...|.|  |||| .| .||||||||. ......||||||.|.|||.. ...||.||| |...
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

VDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPppdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRF
 |||||.||....|.||||.|.|.||.||. |||   . ....|.... |..| .| |||.||. . .. .. .||. .||...|||.||||....||.|
edFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

IHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
...|.. .... |||.||||||||||||||..   ..|. .....|... |. .| .|. .|||. ||.|...||||||
lkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

0050432 (Phosphotyrosine protein) phosphatases II 3211-3491 5.7e-95 313.5 In-house 33-307 (308) alignment
Range on Protein: 3211-3491
Range on HMM: 33-307/308.0
EVFDKEEGKTRLEKEFDNIQETIHrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLstipGvDGSDYINANFIEGY--HKGKAFIATQGPLPDTSDDFWR
. ..|  ....||.||  ....    .  ...    |..|||| ...|.|..| ||    . .|||||||... ||  .. ..|||||||||.| .||||
kllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MVWEHKSSTIIMLANEREGGKAMCHKYWPDS---GTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAegSSQHVKQFQYVSWPSKGVPDSAIGLLDVRE
||||.....|.|| .. | |.  |..|||..   |...|| | .|| |.....||..|........|    | .|..|.| .||  |||.|.  |||  |
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldfle

QVEKWQrnsGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYAN
.|.|..   ...||||||| |.|||||.||  ||...|..|| ||||..|. || |||||| ...||.|.|. .||.| .. |..|
lvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkln

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2912-3202 1.4e-94 311.7 In-house 4-295 (305) alignment
Range on Protein: 2912-3202
Range on HMM: 4-295/305.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQhHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
... |. |.. ......|  . ..| ..  . . . | ...  |. |||...|  .|..|..|||..... ||||||.|.||||....||..|||... .
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

VDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQH-KVSSDERTIKQYHFTSWPDFGVPEHPTTLLR
.||||.|.| |..|.||||.| | |. ||. |||   .... .|.. ..|..| . .||..| ...   . ....||. ||..|.||| |||. .|.||.
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

FIHKVQRENPKNAG-PVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREV
.|..||..  |. | |..|||||||||||.||... .....   . .|... .. .| .|  |||| .|| |.|||| |...||.|..    .
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2924-3197 7.3e-94 309.3 In-house 21-297 (298) alignment
Range on Protein: 2924-3197
Range on HMM: 21-297/298.0
MHANDDYLFSVEYPTVEPQHH----PTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIW
.....   .. |. ...   .     .|.....|.|  |||||.| |.|.||| |... .   |||||| ....||..||.||.|.|......|||||..
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EQKTETVVMLTNLEEKGRIKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQReN
|.. .|.||||||||....|.| |||  |..   .|.|...|... . .|...|.. ...| ...||...| ||||||| ||||. |..| ...||.. .
eedigtiVmltnleeldktkyhkywP..degketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.s

PKNAG--PVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEV
...||  ||.|.|||||||.|||| |.  ....   . .|... |. .| .|. .||||.||.||..| ||.|.....|.
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

0047943 (Phosphotyrosine protein) phosphatases II 2940-3190 7.3e-94 309.5 In-house 22-272 (273) alignment
Range on Protein: 2940-3190
Range on HMM: 22-272/273.0
E-PQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLtedpNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRI
   ... |. ....|.|  |||| .| .||||||||    . .|||||||.|.|||......|| ||| |... |||||.|||.....||||.|.|.||.
lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgre

KCHLYWPPPDKR-VVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK--NAGPVVVHCSAGVG
||. |||.     ....|.... | .| .  |||.||. |... ....||....|.|.|||.|||.... ||.||..|.. . .  . ||||||||||||
kcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvg

RTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
||||||.. . ..|.  ....|... |. .| .|. ||||. ||.|...||||||
RtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2919-3190 3.7e-93 306.7 In-house 10-279 (288) alignment
Range on Protein: 2919-3190
Range on HMM: 10-279/288.0
AHVANMHANDDYLFSVEYPTVEP-QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRM
|.||...|..   || || .. . ... ...|.... || |||| || .||. ||||.. ....|.|||||.||||.||...|||.|||..... |||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRvVVHGQIRIQLQEELSLTDYTIRTFSLQhkVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQR
..|.||.|.||||.| |.|. ||. |||  ||  . .|.. ..|.|.  |.|.. |.. |.   . .|..|.||....||| ||||  . || ....|. 
vyenktstivmltelveggktkCeeYWPdadkp.knyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkv

ENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
 |....||..||||||||||||||.. . |...   . .|. ..|. .| .| ..|||. ||.||...||.  
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_PTPRK_pd Subfamily PTPRK 2912-3226 6.1e-93 306.1 In-house 4-312 (314) alignment
Range on Protein: 2912-3226
Range on HMM: 4-312/314.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQhhptKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
. | |   ..| ..... | |  || ..        ||... .|  |||. .| |||.|||.|.   . | ||||||..||.||. .|.|. |||... .
irvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetv

VDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPppDKRVVvHGQIRIQLQEELSLTDYTIRTFSLQH--KVSSDERTIKQYHFTSWPDFGVPEHPTTLL
 ||||....... ..||||.| |.||.||  |||  ..  | .|.|...| |   |... .|.|....  .  .. |...|..|..|||..|| . |.||
kdfWrlvydencasivmltelvevgrvkClkyWP..edtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgll

RFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLL
.....|.  ....||..||||||| |||||||.|.  .. |  .. .|..| |...| |.  ||.|| ||.||.|..||   |||| . . |.|  .   
klvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyles

NEVfDKEEGKTRLEKEF
... | .   ..|..||
irl.dpqtnssqlkeef

0045450 (Phosphotyrosine protein) phosphatases II 2907-3191 1.1e-92 306.3 In-house 4-305 (307) alignment
Range on Protein: 2907-3191
Range on HMM: 4-305/307.0
SEKGYVSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHP---TKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNV-PGSDYINANYI--------DGY
. . .... ..  .|. ..... ...  |. .. .....   . .....| |  |||| .| .|||.||||.  ..  ..||||||.|.        |||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHK-VSSDERTIKQYHF
.. ...|| ||| |... |||||.|||.....||||.|.|.||.||. |||   . ....|.... | .|  | .||.||. ....  .. .||....|.
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

TSWPDFGVPEHPTTLLRFIHKVQRENPK--NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKC---LDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
|.|||.|||... .||.||..|.. . .  . |||.||||||||||||||..   ..|. ....   .|... |. .| .|. .||.. ||.|...||||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

YLE
.| 
lll

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2919-3191 1.6e-92 304.6 In-house 4-277 (281) alignment
Range on Protein: 2919-3191
Range on HMM: 4-277/281.0
AHVANMHANDDYLFSVEYPTVEP-QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRM
.|......||.  |  || ...  . . |  |.....|  |||| ||.|||..|||.|.. .   .||||||...|||.|..|||.|||||.|.|.||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IWEQKTETVVMLTNLEEKGRIKCHLYWPpPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLqHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKV-Q
.|||| ...||.|.  |.|..||| |||  |.  .  |..... ..| . . |  |.|.| .. |...|...| ..|.||| |||. .. || | ..| .
vweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlk

RENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDR-KCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
 ...|.  |.|.|||||||||||.|..   .... .. . ||. . |...| .| .|||| .|| |.. |.|..|.
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

0039614 (Phosphotyrosine protein) phosphatases II 2910-3193 4e-92 304.1 In-house 12-292 (297) alignment
Range on Protein: 2910-3193
Range on HMM: 12-292/297.0
GYVSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPtKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNV-PGSDYINANYIDGYKK-ENAYIASQGPV
 ..... .....  ..||. .|.  |. ..  . .. .  ...| |  |||| .| .||||||||.  ..| ..||||||.|.|||..  ...||.||| 
ipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

PHSIVDFWRMIWEQKTETVVMLTNLEEKGRiKCHLYWPPPDKrvvVHGQIRIQLQEELSLTDYTIRTFSLQHkvSSDERTIKQYHFTSWPDFGVPEHPTT
|... |||||.|||.....||||.|.|.|| ||. |||.      ..|.... | ..  | .||.||.....  .. .||......|.|||.|||.....
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslel

LLRFIHKVQRENPK--NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECG
||.|...|.. . .  . |||.||||||||||||||..   ..|.  ....|... |. .| .|. .|||. ||.|..|||||.| ..
lleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0046845 (Phosphotyrosine protein) phosphatases II 3222-3491 3.2e-91 300.9 In-house 2-282 (284) alignment
Range on Protein: 3222-3491
Range on HMM: 2-282/284.0
LEKEFDNIQETIHREP-IVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGV-DGSDYINANFIEGY-----HKGKAFIATQGPLPDTSDDFWRMVWEHK
||.||  ..   .     . .. .  |..|||| ...|.|..| ||....|  ..||||||....||     .. |.|||||||||.| .||||||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SSTIIMLANEREGGKAMCHKYWPDSG-TQMYGFFEITLHSMKEYPDYILREFKIVDSrDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN
...|.|| .. | |. .|..|||..| ...|| | .|| |.....||..|......  . .| | .|..|.| |||  |||.|.  ||.  ..|.....|
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-SGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEG---LVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYAN
 .|..|||||||.|.|||||.||  ||...|..||    |||...|. || |||||| ...||.|.|. .||.| .. |...
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle

0040438 (Phosphotyrosine protein) phosphatases II 3218-3487 3.5e-91 301.1 In-house 16-280 (317) alignment
Range on Protein: 3218-3487
Range on HMM: 16-280/317.0
GKTRLEKEFDNIQETIHRepIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSST
..|.|..|| .... ..      ..    |..|||| ...|.| .| ||| ..|. .||||||....|......|||||||||.| .||||||||.....
dftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSrdAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRnSGDK
|.|| .. | |. .|..|||. .|. || | .|| |..|.....||.....|.   .. | .|..|.| .||  |||.|   |||  |.|..... ....
ivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpgg

PIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFD
|..||||.|.|||||.||  |....|..|| |||...|. || ||||.| . .||.|.|. .||.|  ..
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl

subfamily_Ptp69D_pd Subfamily Ptp69D 2911-3207 9.9e-91 299.0 In-house 3-303 (307) alignment
Range on Protein: 2911-3207
Range on HMM: 3-303/307.0
YVSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHP-TKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPH
 ... | .  . . . . |...  || ..| .. . .  .... .||.|||| .| |.|. ||||.. .    ||||||..| |||... .||.|.||  
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

SIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPdkRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKV-----SSDERTIKQYHFTSWPDFGVPEH
 | ||||||.||. ...|||.||.|| | ||. |||      | .|.| ..| .| . .||.||.... .|        |.| . |||.|.|.|. |||.
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

PTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKE
...||..|..|.  . .| .|.||||||||||.|.|....  .||.   ...||...|. .| .| ..||  .||.|.. |||.| . |.|... .....
argllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

QFR
...
aie

DSPc_SM00195 2945-3190 1.6e-90 298.4 In-house 16-262 (263) alignment
Range on Protein: 2945-3190
Range on HMM: 16-262/263.0
PTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYW
 ... .... |  |||| ||  |||.||||..... .||||||||||.|..|...||| ||| |. . |||||.||.|....||||. ||.|..||. ||
ketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PPPDKRVVVHGQIRIQLQEELSLT-DYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITI
|   ..  ..|.|...|.|. .   ....||..|...  ...|...||....||| |||.... .|.....|. .. .. ||.||||||||||||||.||
peesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvti

SCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
.. .... . | .|| . |...|  |. ||||..||.||..|.|||.
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 2945-3190 1.6e-90 298.4 In-house 16-262 (263) alignment
Range on Protein: 2945-3190
Range on HMM: 16-262/263.0
PTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYW
 ... .... |  |||| ||  |||.||||..... .||||||||||.|..|...||| ||| |. . |||||.||.|....||||. ||.|..||. ||
ketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PPPDKRVVVHGQIRIQLQEELSLT-DYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITI
|   ..  ..|.|...|.|. .   ....||..|...  ...|...||....||| |||.... .|.....|. .. .. ||.||||||||||||||.||
peesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvti

SCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
.. .... . | .|| . |...|  |. ||||..||.||..|.|||.
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0047943 (Phosphotyrosine protein) phosphatases II 3213-3483 6.6e-90 296.5 In-house 5-272 (273) alignment
Range on Protein: 3213-3483
Range on HMM: 5-272/273.0
FDKEEGKTRLEKEFDNIQETIHrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLstipGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWE
..|  |.|.|..||. ...... .    ..    |..|||| ...|.|..| ||    | .|||||||....||.....|||||||||.| .||||||||
lekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

HKSSTIIMLANEREGGKAMCHKYWPDSG---TQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEgsSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEK
.....|.|| .. | |.  |..|||..|   ...|| | .|| |.....||..|....... . |  | .|..|.| .||  |||.|   ||.  |.|.|
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllefielvrk

WQRNS-GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
..... ...|.|||||.|.|||||.||  ||.|.|..|| |||...|. || |||||| ...||.|.|. .||.|
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0039614 (Phosphotyrosine protein) phosphatases II 3214-3487 1.3e-89 295.9 In-house 26-293 (297) alignment
Range on Protein: 3214-3487
Range on HMM: 26-293/297.0
DKEEGKTRLEKEFDNIQETIHrePiVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGV-DGSDYINANFIEGYHK-GKAFIATQGPLPDTSDDFWRMVW
.|  .||.|..|| .... ..  .   ..    |..|||| ...|.| .| ||....||  .||||||....||.. ...|||||||||.| .|||||||
ekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

EHKSSTIIMLANEREGGKaMCHKYWPDSGTqMYGFFEITLHSMKEYPDYILREFKIVDsrdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQ
|.....|.|| .. | |. .|..|||..|. .|| | .|| . .....|..|......    .| | .|..|||..||  |||.|.  ||.. |.|....
eqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslellleflelvreal

RNS-GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFD
... ...|..||||.|.|||||.||  |....|..|| |||...|. || ||||.| . .||.|.|. .||.|  ..
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

0036941 (Phosphotyrosine protein) phosphatases II 3218-3489 4.6e-88 290.6 In-house 11-283 (297) alignment
Range on Protein: 3218-3489
Range on HMM: 11-283/297.0
GKTRLEKEFDNIQETIHrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLstipGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSST
....|.|||. ... ..  .   ..    |..|||| ...|.|.|| ||    . .|||||||....||. ...|||||||||.| .||||||||.....
flalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IIMLANEREGGKAMCHKYWPDS--GTQMYGFFEITLHSMKE--YPDYILREFKIVDSrdAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN
|.|| .. | |. .|..|||.   ... || | .|| |...  ..||.||.....|    .| | .|..|.| .||  |||.|.  |||  |.|.|....
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

S-GDKPIVVHCSGGCGRTGTYIATCLLIDRLK---TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTY
. ...|..||||.|.||.||.||  |....|.   .|| ||....|. || ||||.| ...||.|.|  .||.| ...|.
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk

0045450 (Phosphotyrosine protein) phosphatases II 3214-3483 6.5e-88 290.7 In-house 21-304 (307) alignment
Range on Protein: 3214-3483
Range on HMM: 21-304/307.0
DKEEGKTRLEKEFDNIQETIHR-EPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGV-DGSDYINANFI--------EGYHKGKAFIATQGPLPDTS
.. ...|.|.|||  ...  ..      ..    |..|||| ...|.| || |||...|  ..||||||...        .||.....|||||||||.| 
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

DDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQ-MYGFFEITLHSMKEYPDYILREFKIVDSrDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLD
.|||||.||.....|.|| .. | |. .|..||||.|.. .|| | .|| |......|..| ... |. | .| | .|..|.| .||  |||.|   |||
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeelld

VREQVEKWQRNS-GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGL---VDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
  |.|.|..... ...|..||||.|.|||||.||  |....|..||    ||....|. || ||||.| . .||.|.|. .||.|
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0043336 (Phosphotyrosine protein) phosphatases II 3218-3482 1.9e-87 288.5 In-house 18-276 (278) alignment
Range on Protein: 3218-3482
Range on HMM: 18-276/278.0
GKTRLEKEFDNIQETIHrePIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSST
.||.|..|| ....  .  .   ..    |..|||| ...|.| .| ||| ..|. .||||||....||.....|||||||||.| .||||||||....|
lktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IIMLANEREGGKAMCHKYWPdSGTQMYGFFEITLHSMKEYPDYILREFKIVDsrDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRnSGDK
|.|| .. | |.  |..||| .|.. || | .|| ......||..| .....    .| |..| ...|..||  |||.|   |||  ..| .... . ..
ivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsng

PIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
|..||||.|.|||||.||  ||...|..|| ||....|. || ||||.| . .||.|.|. .||.
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2949-3193 4.3e-87 286.5 In-house 3-245 (250) alignment
Range on Protein: 2949-3193
Range on HMM: 3-245/250.0
ATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIkCHLYWPPPD
 ...|.|  |||||.| |.|.||| | ..     |||||| ...||....|.||.|||....|.|||||..|.|..|.||||||.|...  .| |||   
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

krVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK-NAGPVVVHCSAGVGRTGTFITISCQI
     .|.....| ..   .|||.|.. | ..  .|||...|.||..||| ||||. |. | ...|||..... ...||.|.|||||||.|.||.|.. .
..aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

QQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECG
...   | .|...... .|  |  .|....||.|.. ..|..|.. 
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv

subfamily_PTPRB_pd Subfamily PTPRB 3215-3483 6.6e-87 286.2 In-house 20-285 (293) alignment
Range on Protein: 3215-3483
Range on HMM: 20-285/293.0
KEEGKTRLEKEFDNIQETIHREPIVfTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHK
|.. ..|. .|......  . . .. . ... || |||| |..|.|..| ||... . .||||||||.|.||.  . |||||||||.| |||||||||.|
kadsdlrfseeyeelkavgkdqavk.aaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekk

SSTIIMLANEREGGKAMCHKYWPDS-GTQMYGFFEITLHSMKEYPDYILREFKIVDsrdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQ-R
||.|.|| .  |.||  |..|||.   ...||  ..|| . .|. |...||.||      | ....|.|....|||  |||...  |||  ..|.... .
ssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek

NSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.. ..||||||| | |||||.||   |......| .||.| .|  || .|  .| ...|| | ....|..|
taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll

Y_phosphatase Protein-tyrosine phosphatase 2955-3188 1.3e-86 285.2 Pfam-A 1-235 (235) alignment
Range on Protein: 2955-3188
Range on HMM: 1-235/235.0
NAIKNRYANISAYDHSRVKLtedPNVPG-SDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVV
|  |||| .| .||..||||    . .| ||||||||..|||.....||.|||....| |||||.|..|....||||.|||||| ||. |||  ... . 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGQIRIQLQ-EEL-SLTDYTIRTFSLQHKVSSD-ERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQI
.|.|...|. .|    ..||.|...|..| ... .|..||.|.|.||| ||||.|. ||..|.||.... .. |||||||||||||||||..... ..|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

LDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
 .....|....|...| .|. |||...||||...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 2955-3188 1.3e-86 285.2 In-house 1-235 (235) alignment
Range on Protein: 2955-3188
Range on HMM: 1-235/235.0
NAIKNRYANISAYDHSRVKLtedPNVPG-SDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVV
|  |||| .| .||..||||    . .| ||||||||..|||.....||.|||....| |||||.|..|....||||.|||||| ||. |||  ... . 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGQIRIQLQ-EEL-SLTDYTIRTFSLQHKVSSD-ERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQI
.|.|...|. .|    ..||.|...|..| ... .|..||.|.|.||| ||||.|. ||..|.||.... .. |||||||||||||||||..... ..|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

LDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
 .....|....|...| .|. |||...||||...|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 3218-3488 3.4e-86 284.2 In-house 20-288 (305) alignment
Range on Protein: 3218-3488
Range on HMM: 20-288/305.0
GKTRLEKEFDNIQETihrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSST
 .. ||.......|.   |  .. |. . |..|||.......|. |..|.. . .| ||||||....||.. |..|..||||..| .||||...| | ||
sdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

IIMLANEREGGKAMCHKYWPDSGTQ--MYGFFEITLHSMKEYPDYILREFKIVDSRDaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSG
|.||.. .||||  |..|||.| |.   .| |...|.| |...||| |..||   .. .  |. | |.|  .|| .|||..|  ||.. ..|.| |... 
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

DKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDT
..|..|||| | ||||..||  . ..|||.|. ||||.|.. || .|..|| . ||| |..  . | . ..||
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt

0040439 (Phosphotyrosine protein) phosphatases II 2947-3190 4.2e-86 283.8 In-house 3-246 (249) alignment
Range on Protein: 2947-3190
Range on HMM: 3-246/249.0
KDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPP
.. ...| |  |||| .| .||||||||.  |....||||||.|||||.  ...|| ||| |... |||||.||.. ...||||.|.|.||.||. |||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

pdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK--NAGPVVVHCSAGVGRTGTFITIS
  . ....|.....| .. .. |||.||. |...  ...||......|.|||.|||... .||.||..|.  . .  . |||.||||||||||||||.. 
..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

CQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
  ..|.  ....|... |. .| .|. .||.. ||.|...||||.|
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_PTPRA_pd Subfamily PTPRA 3242-3485 2.2e-85 281.5 In-house 53-297 (330) alignment
Range on Protein: 3242-3485
Range on HMM: 53-297/330.0
GTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGT
 .   |..|||. |..|.| .|  ||.. ||. |||||| ||.||.. . |||.|||. .| .|||||.||.||.||.||.. .|  .  |..|||| |.
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl

QMYGFFEITLHSMKEYPDYILREFKIVDSRDAE--GSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDkPIVVHCSGGCGRTGTYIATCLL
  ||   .... ...  || .|.| . .  ||    .|. |.|| . |||  |||  .||.|.. ..|.| ...|.. ||||||| | |||||.|.   .
vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldav

IDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGS
..|.|.|..||||..|. |||||| ||..  ||||.|| .||.   
lervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly

DSPc_SM00195 3222-3483 3.3e-85 280.9 In-house 2-262 (263) alignment
Range on Protein: 3222-3483
Range on HMM: 2-262/263.0
LEKEFDNIQETIHREpIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIML
|..||....|  . .  . ..  . |..|||| |..|.|.|| ||..... .||||||||.|.|..| |..||||||||.| .||||||||.|...|.||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

ANEREGGKAMCHKYWPDS--GTQMYGFFEITLHSMKEYP-DYILREFKIVDSRDaeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSgDKP
 .| | ||  |..|||..  |.. .| ....| . .... ..|||....    .    .. |.|.|| .|| .|||||.  .|.. ..|.|....| ..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgp

IVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|||||| |.|||||.... .....|..|  ||.|..|. || ||||||.. .|| |.|. |||..
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 3222-3483 3.3e-85 280.9 In-house 2-262 (263) alignment
Range on Protein: 3222-3483
Range on HMM: 2-262/263.0
LEKEFDNIQETIHREpIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIML
|..||....|  . .  . ..  . |..|||| |..|.|.|| ||..... .||||||||.|.|..| |..||||||||.| .||||||||.|...|.||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

ANEREGGKAMCHKYWPDS--GTQMYGFFEITLHSMKEYP-DYILREFKIVDSRDaeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSgDKP
 .| | ||  |..|||..  |.. .| ....| . .... ..|||....    .    .. |.|.|| .|| .|||||.  .|.. ..|.|....| ..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgp

IVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|||||| |.|||||.... .....|..|  ||.|..|. || ||||||.. .|| |.|. |||..
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2920-3211 5.1e-85 280.2 In-house 14-301 (315) alignment
Range on Protein: 2920-3211
Range on HMM: 14-301/315.0
HVANMHANDDYLFSVEYPTVE-PQHHPTkDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMI
.||. .|.    |  .| ..   | ||  | ...  |  |||| || |||.|||.|    | |.|||.|||.||||.|.. |||.||| . |. ||||..
yvaqkkastkngfkqdyesipggqlhpl.dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlv

WEQKTETVVMLTNLEEKGRIKCHLYWPppDKrVVVHGQIRIQLQEELSLTDYTIRTFSLQHKvsSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRE
.|..  ..|||||| |. . |.  |||  ||  |..|.| . ...|   |.||.||.|   .  .. |.. |.|.||||| |||.. ..|. .| .|.. 
feedigkivmltnlvegekrkaekywp..dk.kviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirtvkqh

NPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFR-LLNE
. ...|..||||||||||||||||... ..|.   . .|.|||.. .|  |  |||. .|| ||.||||| . ||.| .. .   ...  ||  
htnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllap

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3215-3482 5.9e-85 279.8 In-house 16-278 (288) alignment
Range on Protein: 3215-3482
Range on HMM: 16-278/288.0
KEEGKTRLEKEFDNIqETIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHK
. ...| ...|....  .....  | .|  . | .|||| |..|.| .| ||   . ..|.|||||..|.|..| |..|||||||.|| .|||..|.|.|
sarnrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

SSTIIMLANEREGGKAMCHKYWPDSGT-QMYGFFEITLHSMKEYPDYILREFKIVdsrdAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN
.|||.||..  ||||  |..||||... . || ...|| . ||  |..||.. ..     ...  ...|.|| .|| .|||.|.  ||....||.  . .
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqa

SgDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
   .||.|||| | |||||.||   |||....|  .||. .|  || ||. .|  . ||||.|. .|. 
d.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

0042113 (Phosphotyrosine protein) phosphatases II 2949-3190 1.2e-84 278.8 In-house 3-243 (245) alignment
Range on Protein: 2949-3190
Range on HMM: 3-243/245.0
ATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpd
 ...| |  |||| .| .|||.||||..|.. ..||||||.|.|||.  . .||.||| |... |||||.||.. .|.||||..||.||.||. |||.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

KRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENP-KNAGPVVVHCSAGVGRTGTFITISCQI
. ....|.....| .| .| |||.||...... .. .|.. .||...|||.|||... .||.|.. |..    .. |||.||||||||||||||..   .
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

QQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
.|.  ........ |. .| .|. .|||. ||.|...||||.|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 3245-3491 4.5e-84 276.6 In-house 7-250 (250) alignment
Range on Protein: 3245-3491
Range on HMM: 7-250/250.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAmCHKYWPDSGTQMY
  |..|||||..|..|..|  | .  | . |||||| |..||.. ||||||||||..|  ||||||.|.||.||.||.| .| .|  .|.|||  ... |
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky

GFFEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
|   ..|.| .|. ||. |..|.  |.  . ....|.|...|.|| ||||. |   |.....|.. |...|..|..|.|| | ||.|..||   ...|||
Gdvtvsllskeefadytkrklkl..skakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYAN
.|  ||||.|.. || .||..|.| .|| |.|. ||..| |.. ||.
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar

subfamily_PTPN6_pd Subfamily PTPN6 2940-3193 1.5e-83 275.3 In-house 39-300 (306) alignment
Range on Protein: 2940-3193
Range on HMM: 39-300/306.0
EPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTeDPNVPGSDYINANYIDG--YKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGR
| ..  ... ...|.|. |||| ||  .||.||.|. .|.||||||||||||..   .....|||.|| ... . |||||.|..... .||.|.  |.|.
eakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgk

IKCHLYWPPPDKRVVvHGQIRIQLQEELSLTDYTIRTFSLQH-KVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNA----GPVVVHCSA
 ||  |||   ..   .|.|...  .| ||.||..|..|... | ...||.. ||||.|||| |||..| ..| |...|.|.. . .    ||.||||||
ekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsa

GVGRTGTFITISCQIQQILDRKC---LDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECG
|.||||||| | . ...|  ...   .||...|.|.|  |  .||||.|| |.. |. .|.|  
GiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk

0045098 (Phosphotyrosine protein) phosphatases II 2943-3194 2.1e-83 275.2 In-house 21-276 (278) alignment
Range on Protein: 2943-3194
Range on HMM: 21-276/278.0
HHPTKDATQHPDNAIKNRYANISAYDHSRVKltedpnvpgsDYINANYIDGYkkENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHL
.  .    . ..|. |||| .| .|||||||          |||||.|||||   ...|| ||| |. . |||||.||......||||.|.|.||.||. 
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPPpdKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHK----VSSDERTIKQYHFTSWPDFGVPEHP--TTLLRFIHKVQRENPK-------------NA
|||.  . ....|.... |..|  | |||.||. ...      .  .|.....|...|||.|||..|  . .|...  ... . .             . 
ywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

GPVVVHCSAGVGRTGTFITISCQIQQIldRKCLDIYNFVQSMRYRRCF-MVQTEAQYIFIHDALLEYLECGE
|||.||||||||||||.. . . ....   . .|... |. .| .|.. .||.. ||.|....|||.|..|.
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk

subfamily_Ptp69D_pd Subfamily Ptp69D 3217-3485 2.3e-83 274.8 In-house 19-288 (307) alignment
Range on Protein: 3217-3485
Range on HMM: 19-288/307.0
EGKTRLEKEFDNIQETiHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSS
. .  |.||....... . .    ..    |  |||| ....||||| ||..|.| . ||||||.||.||.. | ||| |.|.  | .|||||..| .. 
dtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

TIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDA---EGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN
.|.||.|. |  .. |.||||.  .. ||   ..| | .. .||| ||...    .    .  |..| |..| .|.   ||..| |||.. |||.. ...
livmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

SgDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGS
.   ||||||| | ||.|...| ..|...||.|  ||.|..|..|| ||. .|.| .||.|.|...|..   
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy

subfamily_PTPRK_pd Subfamily PTPRK 3244-3481 2.3e-82 271.3 In-house 40-275 (314) alignment
Range on Protein: 3244-3481
Range on HMM: 40-275/314.0
ASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQm
   ||.|||. .....|..| .| || |   ||||||..|..|.. .|||.|||||..|  ||||.|.......|.||..  | |.  | ||||. ... 
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.

YGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNsGDKPIVVHCSGGCGRTGTYIATCLLIDRL
|| ....| ...   ... | |..  .  .    . |.|||...||. .|| || |||..  .|.|.| . .. .|||||| |.|||||.|| . ..| .
ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmi

KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
..||.||||..|. || ... ||   .|| |.|  |||
eregvvdvfnavktlrsrkvnmveteeqykfiydvile

0040439 (Phosphotyrosine protein) phosphatases II 3245-3483 2.3e-82 271.6 In-house 9-246 (249) alignment
Range on Protein: 3245-3483
Range on HMM: 9-246/249.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMY
  |..|||| ...|.| .| ||| .||. .||||||..|.||. ...|||||||||.| .|||||.||.....|.|| .. | |.  |..|||..|.. |
penkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsley

GFFEITLHSMKEYPDYILREFKIVDSrdAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNS-GDKPIVVHCSGGCGRTGTYIATCLLIDRL
| | .|| |.....||..|.......   .|.| .|...||..||  |||.|   |||  |.|.|....   ..|..||||.|.|||||.||  |....|
gdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql

KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
..|. ||....|. || ||||.| . .||.|.|. .||.|
ekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 3193-3484 4.1e-82 271.0 In-house 7-294 (319) alignment
Range on Protein: 3193-3484
Range on HMM: 7-294/319.0
GETEVSAREVKEQFRLLNEVFDKEEGKTRLEKEFDNIQETIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAF
||..|. .... ... |    | .. .|.|| || .. .              .|. |||. |...|||.. ||  . |...|||||| |..|| . . .
gesdvavpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdky

IATQGPLPDTSDDFWRMVWEHKSSTIIMLAnereggKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEgSSQHVKQFQYVSWPSKG
||.||||..| .|||||.||...|||..|.      | .| .|||  . . .. |.. ..|..|  .|..|.... .    .   ....|| .  || .|
iaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkek.dirkitqfhflGwpdvG

VPDSAIGLLDVREQVEK-WQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE--FLG
|||... |. . ..|..  ... . ..|||||| |.||||.||.   |.||.| |  |||...||.|| ||. .|... || |.| ..||  ..|
vpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

subfamily_PTPRG_pd Subfamily PTPRG 3217-3488 4.5e-82 271.1 In-house 16-292 (563) alignment
Range on Protein: 3217-3488
Range on HMM: 16-292/563.0
EGKTRLEKEFDNIQETIHREPI-VFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGS-DYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHK
.|......||...|...  . . . .  .  |..|||| |....|..| ||| .||.... ||||||.|.||.|.||||||||||.|| ||||||.||..
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

SSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEG----SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKW
...|.|..|  | |.  |. |||  ... || ...|| . .    |  |...| . .  ..    . ..|.|..| .|| .|||....  |   .. .. 
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

QRN-SGdkPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDT
...  |  ||||||| | |||||||.   |. ....|  |.||.... .|.||. .| . .|| | .. .|| . | .|
nkaeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2913-3228 6.7e-82 269.8 In-house 4-314 (315) alignment
Range on Protein: 2913-3228
Range on HMM: 4-314/315.0
SVGDFPAHVANMhaNDDYLFSVEYPTV-EPQHHPTKdATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
 | .||| | .       ||| |.  . .|. .... ......|  |||| ||  .|..||||    . | |||||| || ......|||||||| . |.
pvaqfpafvnkn..rhtalfseefhdlpdPdiyrqr.varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

VDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFslQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRF
 |||||....|. |.||.|...|  .|||  |||  .   |  |.|...| .  . || ..| .    . | . ||. |..|| ||| ||... ..||..
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllkl

IHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLNE
|..|. .| |.  ...||||||||||| .|.|   ..|| ... .|..|||. .|  | ..|||| .| ||.||.||.|   .| .    . .... |. 
ikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlht

VFDkEEGKTRLEKEFDN
  |  .|.... |||..
svd.gsgrskmtkefet

0042113 (Phosphotyrosine protein) phosphatases II 3246-3483 5.2e-81 266.9 In-house 8-243 (245) alignment
Range on Protein: 3246-3483
Range on HMM: 8-243/245.0
PNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYG
 |..|||| ...|.| || ||| ..|  .||||||... ||.  . |||||||||.| .|||||.||....||.|| .| | |.  |..|||..... ||
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltyg

FFEITLHSMKEYPDYILREFKIVDsrDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKT
 | .|| |.. ..||..|......  . .. |..| ...|..||  ||||.   |||. | |.|........|..||||.|.|||||.||  |....|..
dftvtllseehlddytvrtlevtn..lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek

EGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|. |.....|. || ||||.| . .||.|.|. .||.|
elgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_PTPN12_pd Subfamily PTPN12 2947-3191 1.5e-80 265.2 In-house 32-278 (290) alignment
Range on Protein: 2947-3191
Range on HMM: 32-278/290.0
KDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPP
..|.... |  |||| .|  ||.|||.|... ...||||||||.| | ... .|||.|||.|. . ||||||||...| |||. .. | |..||. ||| 
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

PDKRVVVHGQIRIQLQEELSLT-DYTIRTFSLQHKvsSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISC
  .. . .|.....|.||  .. |..|||. ....  ...|...|.|.|.||| |||. ...||..|..|.. . ... |.||||||||||||| |.|  
egeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidy

QIQQILDR---KCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
  ... ..   ..||... |...| .|  .|||. || ... |..|...
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_PTPN9_pd Subfamily PTPN9 2946-3190 2e-80 265.0 In-house 33-290 (297) alignment
Range on Protein: 2946-3190
Range on HMM: 33-290/297.0
TKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWP
| .|.... |  ||||...  ||..||.|.. .. . |||||||..||||...|.|| |||... . |||||.|||.. ..|| | ..|.||.||  |||
tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWp

PPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQREN-------------PKNAGPVVVHCSA
. .. .  .|.....  |  .  ||..|.. ...   ...|..  . |.||||.|||.  ..|| ...||...              . .  |.||||||
leeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsa

GVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
|.||||||||.   .... .   .|. . |. .| .| |..||. || | . |.||| 
GiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2915-3237 4.2e-80 264.3 In-house 5-322 (515) alignment
Range on Protein: 2915-3237
Range on HMM: 5-322/515.0
GDFPAHVANmhANDDYLFSVEYPT-VEPQHHPTKdATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVD
 .||| |.   ..   ||| |.     |. .|    .|   |  |||| ||  || .||||    . | |||.|| || ... ..|||||||| . |. |
aqfPafvnk..nrhttlfseefhdlpgpniypqt.vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvdd

FWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHkvSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIH
|||....... |..|.|.|.|  .|||  |||      |  |.|...|    . |. ..|.. . .  ..| ||. |.||| ||| |||.| ..||..|.
fWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlk..gddsrtvtqfhfteWPdkGvpkhtssllklik

KVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLNEVF
.|. .. . . |...|||||||||| .|.|   . .. . . .|..|||. .| .| ..|||. || ||..|.||.|   .| .      .... |    
evkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssg

DKeEGKTRLEKEFDNIQETIHREP
|  .|.... |||. ..  .   |
dg.rgrskmtkefqtlkslcpdpp

0045098 (Phosphotyrosine protein) phosphatases II 3239-3484 1.1e-79 263.0 In-house 25-273 (278) alignment
Range on Protein: 3239-3484
Range on HMM: 25-273/278.0
VFTGTASPNRHKNRYANVIPFDKTRCKlstipgvdgsDYINANFIEGYhkGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPD
....    |..|||| ...|.| .| |          |||||..|.||  .|.|||||||||.| .|||||.||.....|.||... |.|.  |..|||.
itpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

SGTQMYGFFEITLHSMKEYPDYILREFKIVDS--RDAEGSSQHVKQFQYVSWPSKGVPDSA--IGLLDVREQVEKWQR------------NSGDKPIVVH
.|.. || |..|| |.....||.|| .....   ..... | .|....|..||  |||..     .|.. |.......            .....|..||
ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CSGGCGRTGTYIATCLLIDRLktEGLVDVFQVVRGLRLQRPG-MVRSVDQYEFCYKSILEFLG
|| |.|||||..|  |....|  || ||....|. || |||| .| . .||.|.|. .||.| 
CsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

Y_phosphatase Protein-tyrosine phosphatase 3247-3481 1.1e-79 262.5 Pfam-A 1-235 (235) alignment
Range on Protein: 3247-3481
Range on HMM: 1-235/235.0
NRHKNRYANVIPFDKTRCKLstiPGVDG-SDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWP--DSGTQM
|..|||| ...|.|||| ||    | .| |||||||...||.. |.||||||||..| .|||||||..|...|.||... | |.  |..|||  ......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGFFEITLH-SMK-EYPDYILREFKIVDSRDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQrNSGDKPIVVHCSGGCGRTGTYIATCLLID
|| ....|  . | .  .|.||.... .. . .  ...|||..| .|| .|||.|. .|||. ..|||.. .. ..|.||||| |.|||||..|  .|..
ygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

RLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
.|..|. |||.|.|. || |||||| |..||.|.|| |||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 3247-3481 1.1e-79 262.5 In-house 1-235 (235) alignment
Range on Protein: 3247-3481
Range on HMM: 1-235/235.0
NRHKNRYANVIPFDKTRCKLstiPGVDG-SDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWP--DSGTQM
|..|||| ...|.|||| ||    | .| |||||||...||.. |.||||||||..| .|||||||..|...|.||... | |.  |..|||  ......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGFFEITLH-SMK-EYPDYILREFKIVDSRDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQrNSGDKPIVVHCSGGCGRTGTYIATCLLID
|| ....|  . | .  .|.||.... .. . .  ...|||..| .|| .|||.|. .|||. ..|||.. .. ..|.||||| |.|||||..|  .|..
ygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

RLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
.|..|. |||.|.|. || |||||| |..||.|.|| |||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 3245-3484 5.9e-79 260.5 In-house 23-258 (284) alignment
Range on Protein: 3245-3484
Range on HMM: 23-258/284.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLAnereggKAMCHKYWPDSGTQMY
 .|. |||. ....|||.. ||  . |...|||||| ||.|| . . .|||||||..| .|||||.||...|||..|.      | .| .|||  . . .
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

GFFEITLHSMKEYPDYILREFKIVDSRDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEK-WQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRL
. |.. ..|..|  .|..|.... .    .   ....|| .  || .||||... |. . ..|..  ... . ..|||||| |.||||.||.   |.||.
erfkvkvdsveeseeyvvrdielsedgkek.dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrm

KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE--FLG
| |  |||...||.|| ||. .|... || |.| ..||  ..|
keekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 3220-3483 9.3e-79 259.4 In-house 15-276 (281) alignment
Range on Protein: 3220-3483
Range on HMM: 15-276/281.0
TRLEKEFDNIQETIHREPIVfTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTII
. . .|......   ... .   .|  |..|||| |.. .|.|| |..       .|||||||..||.. |..||||||.|.. ..||.||||.| |.|.
aGfieeyeklaaigvdntat.askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLANEREGGKAMCHKYWPDSG-TQMYGFFEITLHSMKEYPDYILREFKIvdsRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDKP
|...| |.||  ||.||||   .  || . .. .. .| . || |.||.   .  .| ...|.|..|..|| .|||...  ||. |..|.| .... . |
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl...eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkap

IVVHCSGGCGRTGTYIATCLLIDRLKTE-GLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.|.||| | ||||||||   |......|   .|| .||. || .|  ||..| |||| || .|. |
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 3213-3489 1.4e-78 258.7 In-house 13-289 (290) alignment
Range on Protein: 3213-3489
Range on HMM: 13-289/290.0
FDKEEGKTRLEKEFDNIQEtIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGV-D-GSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMV
 .. .|... ...|  ..   ..|  | .|..| |...||.||... |  |  |  |.|  |   .|||| .|.||.. |..||||||...|  |||...
nghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

WEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKW
|..|.. |.|| |. | ||  |..|||||.|..|| |.|.|.. ... .|| |.... ... | |..|.|.|.|  .|.|.|      . | | |...| 
wqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemykt

QRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTY
|| .|...||||||.. ||.....|.   |.. |||| .|||||.. .| |.||.| .|.||.. .. .|. | ||.||
qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2929-3199 1e-77 256.6 In-house 33-300 (319) alignment
Range on Protein: 2929-3199
Range on HMM: 33-300/319.0
DYLFSVEYPTVEPQHHP--TKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETV
   . ||.  .  .  .  ... .  ..|  |||. || |.|...|||     . .|||||| ...||.... |||.||| . .. ||||||||... |.
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLTnleekgRIKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQH-KVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNA--
|.||      . ||  |||   | |. ...  ....      .|..| . | .     | | |.|.||  ||| |||..|. |.|...||.  . |.   
vllt......kdkcsqywp..lkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

GPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSA
 ..||||||||||||..|.. . .... . | .|.||||. .| .|  .||  .|| ||. ||||    | ..|. 
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvam

0037934 (Phosphotyrosine protein) phosphatases II 2950-3190 1.6e-77 255.6 In-house 5-242 (243) alignment
Range on Protein: 2950-3190
Range on HMM: 5-242/243.0
TQHPDNAIKNRYANISAYDHSRVKLtedpnvPGSDYINANYIDGYKKenaYIASQGPVPHSIVD----FWRMIWEQKTETVVMLTNLEEKGRIKCHLYWP
 ..| |  |||| .| .||||||||      .||||||||.|.....   .||.||| |... |    ||||.||......||||.|.|.||.||. |||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

ppDKRvvVHGQIRIQLQEELSLTDYTIRTFSLQHKV-SSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRE--------NPKNAGPVVVHCSAGVGR
  ..   ..|.....| .| .| |||.||..|...  .  .|.. .||...|||.|||..|. ||.|...|.          . .. |||.|||||||||
..gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTFITISCQIQQIldrkCLDIYNFVQSMRYRRCF-MVQTEAQYIFIHDALLEYL
|||.|..   ....    ..|... |. .| .|.. .|||. ||.|...||||.|
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_PTPN12_pd Subfamily PTPN12 3215-3483 2.6e-77 254.5 In-house 3-277 (290) alignment
Range on Protein: 3215-3483
Range on HMM: 3-277/290.0
KEEGKTRLEKEFDNIQETIHR---EPI--VFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRM
..||. ...||| ..... ..   | .    .|... |..|||| ...|.||.| .||.| ...||||||||||.| .. ...||.|||||.| ||||||
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

VWEHKSSTIIMLANEREGGKAMCHKYWPDS-GTQM-YGFFEITLHSMKEYP-DYILREFKIVDSrdaeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQ
.||.. . ..|. .| | ||  |..|||.. .... .| ||.||.. |    |...| .|.  .    . |..|.||.| .|| .||| ||  ||.. |.
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssakslleliel

VEKWQRnSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGL---VDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|.. |. | |.|.||||| |.||||| ||  .  . ||.| .   .|||..|. || ||. .|.. .|||. ||...|..
vrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2910-3227 1e-76 253.2 In-house 3-324 (325) alignment
Range on Protein: 2910-3227
Range on HMM: 3-324/325.0
GYVSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPH
| ..| ..  || . .|.|.  |. |.  . ..   .| .. .|.|  |||. |. |.|.||| |    . | ||||||.|.  .|| . ..|.| | ..
gsiavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPlta

SIVDFWRMIWEQKtETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLL
.| |.||.. . .  .||...|  ..|  .|  |||      .  | ....|.    ..||  | . ..     . |..||... ||.|.||...|.||.
tindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatli

RFIHKVQ------RENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVK
 ... |.      . | | ..|..|||||||||||.||.. . ......   .||..||. .|  |  ||.|  |||.|..|| |.. .|.|.|    ..
silqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfe

EQFRLLNEVFDkEEGKTRLEKEFD
 ..  |.|       |  .||||.
aklsslqernp.ltqklniekefe

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 3214-3492 1.1e-76 252.5 In-house 14-287 (287) alignment
Range on Protein: 3214-3492
Range on HMM: 14-287/287.0
DKEEGKTRLEKEFDNIQETIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLStipgVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEH
....|..  .. |  ...  .||  |  . || |..|||...... |. |  |         ||||| ||.||.. ||||....|. .|  .||......
ghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddr

KSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRdAEGSSQHVKQFQYVSWPSKG-VPDSAIGLLDVREqVEKWQR
. ..|.||..|.|  . .|..|||.. . ..| ..|.| . . . .|| |....  .   .|. |.|||.|. .|.|.| |.. .  || . |   | ||
nvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn.kagdkqqvkqyqitnWdstgkvtepqtillviee.myktqr

NSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYANF
 .|. .|||||| . ||.....|    |.. |||| .|||||..  | |.||.|. |.||.| .. .||.| ||.||..|
krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2950-3203 1.7e-76 252.4 In-house 20-268 (284) alignment
Range on Protein: 2950-3203
Range on HMM: 20-268/284.0
TQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTnleekgRIKCHLYWPppDK
.  ..|  |||. .| |.|...|||     . .|||||| .| ||.... |||.||| . .. ||||||||... |.|.||      . ||  |||   |
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp..lk

RVVVHGQIRIQLQEELSLTDYTIRTFSLQH-KVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNA--GPVVVHCSAGVGRTGTFITISCQ
 |. ... .....      .|..| . | .     | |.|.|.||  ||| |||..|. |.|...||.  . |.    ..||||||||||||..|.. . 
ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvl

IQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVK
.... . | .|.||||. .| .|  .||  .|| ||. ||||    | ..|.  .. 
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfp

subfamily_PTPN6_pd Subfamily PTPN6 3195-3483 4.6e-76 250.7 In-house 2-297 (306) alignment
Range on Protein: 3195-3483
Range on HMM: 2-297/306.0
TEVSAREVKEQFRLLNEvFDKEEGKTRLEKEFDNIQETIHREPI-VFTGTASPNRHKNRYANVIPFDKTRCKLStIPGVDGSDYINANFIEGYHKG--KA
|.. |.|.... . |..  ... .|. .|.||...|.. ... .    |.   |..|||| |..|||.|| .|.  |.| ||||||||.|..  ||  |.
tsllakeieqrvselek.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdks

FIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGT-QMYGFFEITLHSMKEYPDYILREFKIVDsRDAEGSSQHVKQFQYVSWPS
.||||| |..|  |||||||. .|  |.|. .| | || .| .||||. . ..||  ..|  | |.  ||||||...   .. ......| |... ||| 
yiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvsk.kkkkkeerevfqyhfksWPd

KGVPDSAIGLLDVREQVEKWQRNSG---DKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGL---VDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.||| .   .||  |.|.. |...      ||||||| | |||||.| . .|.. ....||   .|. ..|. .| || |.|.  .|| | ||.| ...
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2941-3192 7.9e-76 249.7 In-house 15-270 (274) alignment
Range on Protein: 2941-3192
Range on HMM: 15-270/274.0
PQHHpTKDATQHPDNAIKNRYANISAYDHSRVKL-TEDPNVPGSDYINANYIDGYK-KENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRI
|  . ... .. . .. |||| .|   ..||| | .|... . |.||||||| ||. ...||.| |||.|. . ||||||...... .||||.|.|. . 
Plnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneq

KCHLYWPPPDKR--VVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSsdERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQREN---PKNAGPVVVHCSAG
||. |.|   .      .|.. |. .. ..  ||..|...|..  .  ||..| | .|.|||  .|....|||.....|....    ....|||||||||
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

VGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLEC
.|||| ||.||  ..|. ... .|. . |  .|  |  ||||. || .|| || .||..
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr

subfamily_PTPN9_pd Subfamily PTPN9 3215-3483 1.1e-75 249.4 In-house 11-290 (297) alignment
Range on Protein: 3215-3483
Range on HMM: 11-290/297.0
KEEGKTRLEKEFDNIQETIHREpIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHK
||.||  | ||. .|...      . .     | .||||..|. .|.|| .|..... . ||||||||..||.. ||||||||||. |..||||||||..
kekgkrGlskeyaeirnepveG.tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqe

SSTIIMLANEREGGKAMCHKYWP--DSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDaeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEK---
  .|.| .   | |.  | .|||  .  .. .|.....  ...|. ||  | ..| ....  . |..|  ||..|||  |||.||  ||||.|.| .   
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt..eesrkvthfqflsWPdyGvPssaaslldvlekvrekqa

---------WQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
         |. .  . ||||||| | |||||.|.  . ..||...| |||...|. || ||  ...  .||||||...||. 
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 3244-3488 1.6e-75 248.9 In-house 46-284 (315) alignment
Range on Protein: 3244-3488
Range on HMM: 46-284/315.0
ASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSgTQM
 . |..|||| |.|..||.| .|  .   ..|||.|||||.|| | . .||.|||.. . .||||.|.|.. ..|.||.|  || | .. |||||    .
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kvi

YGFFEITLHSMKEYPDYILREFkivdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGdKPIVVHCSGGCGRTGTYIATCLLIDRL
|| . .|. | . . .|  | .    |   .   ..| |..| |||  ||| ..| |...  .| ... ||   .|||||| | |||||.|.   ..|..
yGkitvtrkseevnteytvrtl....svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqa

KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDT
..| ..||.....|.| .| .||....||.| |. .|| .   ||
eaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdt

0037934 (Phosphotyrosine protein) phosphatases II 3246-3482 1.2e-73 243.0 In-house 9-241 (243) alignment
Range on Protein: 3246-3482
Range on HMM: 9-241/243.0
PNRHKNRYANVIPFDKTRCKLstipgvDGSDYINANFIEGYHKgkaFIATQGPLPDTSDD----FWRMVWEHKSSTIIMLANEREGGKAMCHKYWPdsGT
 |..|||| ...|.| .| ||      .||||||||.|... .   .||||||||.| .|    ||||.||.....|.|| .. | |.  |..|||  |.
enlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..ge

QMYGFFEITLHSMKEYPDYILREFKIVDsRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN-------SGDKPIVVHCSGGCGRTGTYI
..|| |..|| |.....||..|.....   |... ...| ...|..||  |||||   |||  ..| .....       ....|..||||.|.|||||.|
vtygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

ATCLLIDRLkteGlVDVFQVVRGLRLQRPG-MVRSVDQYEFCYKSILEF
|  |....|   | ||....|. || |||| .| . .||.|.|. .||.
aaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2912-3197 1.4e-73 242.3 In-house 2-285 (287) alignment
Range on Protein: 2912-3197
Range on HMM: 2-285/287.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDAT--QHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsDYINANYIDGYKKENAYIASQGPVPH
..|. |   ||. ||. .  |.  . ..|   .  .. |    ..|  |||...|  .|  || | .  .    ||||| .|||||...|.|....|. .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehp....dyinavfidgykekkafiiaesPmfn

SIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKrvVVHGQIRIQLQEELSLTDYTIRTFSLQHKV-SSDERTIKQYHFTSWPDFG-VPEHPTT
 ...||..|.... ...|||....|. . .|. |||  .   || |. .|.| .|   ..|..|.. ...|  ..|....|||..|.|.. | |.|. | 
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

LLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEV
|| . .... .  .  ...|||||..|||...|. .   |..      .|... ..|.| ..  .||| .||.|| |..||||...|| .
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2912-3195 6.9e-73 240.0 In-house 2-288 (290) alignment
Range on Protein: 2912-3195
Range on HMM: 2-288/290.0
VSVGDFPAHVANMHANDDYLFSVEYPTVEPQ-HHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPG--SDYINANYIDGYKKENAYIASQGPVP
. |..|  .||| ||. .  |  .. ...   .. |      ..|  .||.|||  ||  |. | . .. .    .|||| ||.|||....||| ||||.
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

HSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVvvHGQIRIQLQEELSLTDYTIRTFSLQHKVS-SDERTIKQYHFTSWPDFG-VPEHPT
. .||||..||..|.  .|||||  |.|. ||. |||  | .    |...|.|..| .|..|..|......| |  ......||..|.|.. | |... |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

TLLrFIHKVQR-ENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGET
 ||  |..... .  .  ...|||||..|||...|...   |..       |... ..|.|  .  .|||. || .|.. .|.||.. ||
ill.vieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet

subfamily_PTPN3_pd Subfamily PTPN3 2948-3188 2.6e-72 238.1 In-house 34-273 (280) alignment
Range on Protein: 2948-3188
Range on HMM: 34-273/280.0
DATQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsDYINANYID----GYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLY
.|.. |.|. |||| .|..||. ||||.| ..    |||||||..    . .  | |||.|||....  |||.|.||||....||||.| |.||.||| |
saarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPPPDKRvVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITI
|| .... . .|........| . . | .| . |..| ...||.| |  ...||| |||.... .|.|...|..    .  |||||||||.|||| .|..
WPetede.leygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

SCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
   .. |  .. . . . |. || .|  .|||..|| |. .|.|.
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2954-3188 1.5e-71 235.4 In-house 2-237 (237) alignment
Range on Protein: 2954-3188
Range on HMM: 2-237/237.0
DNAIKNRYANISAYDHSRVKLTEDPNvpGSDYINANYIDGYKK-ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRvV
.| |||||.|| ||||||| |    .  |||||||.|..|.    . |||.|||.  |  |||.|.|..|   .|||| | |. ..||| |||  |.   
enkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp.a

VHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDE-RTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK--NAGPVVVHCSAGVGRTGTFITISCQIQQ
 .|.. . |. .  ..|||.|.. |.....  | | |.||.|||||| |||.. ..|||| ...  ..|.  ..|| ..|||||||||| |. | . ..|
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

ILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
  ..| .||||.|.|.   | ...||. ||.|||...||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_PTPN13_pd Subfamily PTPN13 2948-3191 6.4e-71 233.8 In-house 30-270 (273) alignment
Range on Protein: 2948-3191
Range on HMM: 30-270/273.0
DATQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsdYINANYIDGY--KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWP
. ... .|  |||| |.  ||..|||| .. .     ||||..|     |.|  |||.|||.|... |||.|.||||.| ..|.|.  |||..||| |||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

PP-DKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPkNAGPVVVHCSAGVGRTGTFITIS
   .|...|.......| .   | ....|.. .... |.. | . . .|..||| ||| ... ||.|. .|.| .  .|||.|||||||.||.||.||| 
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

CQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
  .. |   | .|. . |...| .|  .|||. ||||.. |.|| |.
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2915-3207 1.1e-69 230.0 In-house 5-296 (439) alignment
Range on Protein: 2915-3207
Range on HMM: 5-296/439.0
GDFPAHVANMHANDDYLFSVEYPTVEP---QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSI
 .|  || ... |.. .|. .. ...    ...     . .  .  |||| ...|.||.|| | | | || | |||||||.|| ... |||.|||  .. 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

VDFWRMIWEQKTETVVMLTNLEEKGRikchlYWPPPDKrvVVHGQIRIQLQEELSLTDYTIRTFSLQHK--VSSDERTIKQYHFTSWPDFGVPEHPTTLL
 ||||...|.|| |.|||||| |  .     |||  ..  |..|.| .. . .. | .|.|| | .  .   .  |||. |.|...|||  || . . .|
ddfwrlviekktvtivmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl

RFIHKVQRENP-KNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFR
 |.. ..  |  .. |||||||||||||||| |..   ..|.   . .||   |. .| .|  |||. .||.||..|.|| .  |.. |.  |.| .| 
dflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkefn

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2911-3199 6.8e-69 227.2 In-house 9-293 (297) alignment
Range on Protein: 2911-3199
Range on HMM: 9-293/297.0
YVSVGDFPAHVAN-MHANddyLFSVEYPTVePQH-HPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKenAYIASQGPVP
 . . ||.. | . .|..   .|| |.  . |.    ..  ...  |  |.||.||  || |||||    . | |||.|| .. |.|.   .|..| | .
piplsdfatlvqknrhtd...vfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmk

HSIVDFWRMIWEQKTETVVMLTNLEEKGRiKCHLYWPppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPE--HPT
 .. |||.|...... |.|||....|. . ||  ||.  || |.  |.. ..|.   . . .  |......  .  .| .|||.|..|||  |..  . .
atvadfWamvldeqvstivmlnddnerdk.kcaryWs..dkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsas

TLLRFIHKVQRENPKNAG-PVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSA
.|| .|. |. .  .||  |..|||.||||||| ..||   . .. . | .||...|. .|  | ..|||. || |.. |.||.| . .|.. |
sllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2952-3188 3e-68 224.6 In-house 5-239 (239) alignment
Range on Protein: 2952-3188
Range on HMM: 5-239/239.0
HPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKK-ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKR
.  |  ||||||| .|||||| | .  | | ||||||.|.  |    .||||.|| |  |  |||||.|...   .|||| | |  . ||| |||    .
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

vvvHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQI
   . ..|. |..   ..|| |||| . .   ..|| . ||||| ||| |||.. |..| . .|. ...   | | |.||||||||||.|. | . ..| 
...ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

LDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
  .| .||.|.|...|  | .||||  ||.||| |.||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2954-3188 3.1e-68 224.5 In-house 6-238 (239) alignment
Range on Protein: 2954-3188
Range on HMM: 6-238/239.0
DNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKK-ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRvv
 |  ||||||| .|||||| | .  | | ||||||.|.  |    .||||.|| |  |  |||||.|...   .|||| | |  . ||| |||    .  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..

vHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILD
 . ..|. |..   ..|| |||| . .   ..|| . ||||| ||| |||.. |..| . .|. ...   | | |.||||||||||.|. | . ..|   
.ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

RKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
.| .||.|.|...|  | .||||  ||.||| |.||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 3221-3483 3.8e-68 224.5 In-house 6-268 (274) alignment
Range on Protein: 3221-3483
Range on HMM: 6-268/274.0
RLEKEFDNIQETIHREPIVFTGtaspNRHKNRYANVIPFDKTRCKL-STIPGVDGSDYINANFIEGYH-KGKAFIATQGPLPDTSDDFWRMVWEHKSSTI
 ||||| ..    ..| .  .|    . .|||| ...| ...|  | |  .  . |.|||||.| ||. . ||..||||||| | .|||||....... |
dlekeflelPlnfdqeeldvfg....sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

IMLANEREGGKAMCHKYWPDSGTQ----MYGFFEITLHSMKEYPDYILREFKIVDSRDaegsSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNS
.||.. .|  .. |..|.||.        || .||. ....|  || .|.. .  . .    ...|| . | .|| . .||.|  |||. ..||. ....
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesreee

GDK--PIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
  |  |.||||| | |||| .||. . . .|. |. |||...|  |||.| |||.. .|||. .. . ..|
naklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl

subfamily_PTPN1_pd Subfamily PTPN1 2943-3192 1.2e-67 222.7 In-house 21-273 (290) alignment
Range on Protein: 2943-3192
Range on HMM: 21-273/290.0
HHPTKDAtQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHL
..||..| ..| |  .||| ..| |||||.|| .. |    |||||. ..  . .  || .|||.|. .  ||.|.||||. .|||| .. ||..|||. 
dfptrea.klpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPPPDK--RVVVH-GQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQREN--PKNAGPVVVHCSAGVGRT
|||  ..   ....  .....| .| .   ||.|.. |. . . . |.| ..|.|.|||||||| |...|.|..||..     .. ||.|.|||||.||.
ywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs

GTFITISCQIQQIL---DRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLEC
|||. . . . .|    | ...|| . .  .|  |  ..||  |  | . |.||   .
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv

subfamily_PTPN13_pd Subfamily PTPN13 3222-3485 2e-67 222.3 In-house 13-271 (273) alignment
Range on Protein: 3222-3485
Range on HMM: 13-271/273.0
LEKEFDNIQEtIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGvdgsdYINANFIEGYHK--GKAFIATQGPLPDTSDDFWRMVWEHKSSTII
 ..||....| ..    . .|    |..|||| ||.|.|.|| ||.   |     ||||..|.         .||.|||||.| .|||.|||| |.. |.
Paeefkelre.lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

MLANEREGGKAMCHKYWPDSG---TQMYGFFEITLHSMKEYPDYILREFKIVDSRdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRnsGD
|...|.|.||  ||.|||.|    ..... .|..|  .... .. .|.... ||.   | |..| ....|.||  ||| ||  || .  .| . |.    
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse..sgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..da

KPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGS
 ||||||| | ||.||.|.   ... .. .  .|| ..|| || || |.|.. ||| |.||.||| |.|
gPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 3215-3482 7.4e-67 220.1 In-house 5-276 (287) alignment
Range on Protein: 3215-3482
Range on HMM: 5-276/287.0
KEEGKTRLEKEFDNIQETIHREPIVFTG-TASPNRHKNRYANVIPFDKTRCKLSTIPgVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEH
. . |  ..||.|...|  .  ...|   .   . .|||||.|.|.|.||  ||. .   ||||||||.. .|.. .||||.|||.. |  ||||.|.|.
errvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravlet

KSSTIIMLANEREGGKAMCHKYWPDSGTQMY-GFFEIT-LHSMKEYPDYILREFKIVDsrdAEGSS-QHVKQFQYVSWPSKGVPDSAIGL----LDVREQ
.|...|... | | ..  |.||||.    |  | . .. |   .  |.|  | ....|   .|.   . |||....|||.|... .|.||    |||...
rsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlid...letrearvvkqldllswPdkvlaPtavglirfvldvkqh

VEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
.|  .  |.  |.|||.. | ||.|...||  |..||.  | ||| .||  || .| ..|..| |. . |...  .
ielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3234-3487 1.1e-66 220.2 In-house 34-292 (325) alignment
Range on Protein: 3234-3487
Range on HMM: 34-292/325.0
HREPIVFTGTASP-NRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKsSTIIMLANEREGGKAMC
  ..| .. .. | |. |||. ||...||.|  | |      ||||||.... . | . |.|.| ||..| .|.||.| . . ...... || ..||  |
sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrc

HKYWPDS--GTQMYGFFEITLHSMKEYPDYILREFKIVDSRdaEGSSQHVKQFQYVSWPSKGVPDSAI---GLLDVREQVEKWQRN--SGDKPIVVHCSG
 .|||.    .. .| .|. | ...|. ||. | ... . .  .| .. |||||. ||.  ||.        .|.. ..|..  .    .  ||.|||| 
avywpkemgksktfGglevklrtieeisdyvhrvldvkqvk..kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

GCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFD
| ||||..|.   ..... .|  ||.|..|. || .|| ||..|||| ..|... |.. | .
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3233-3489 1.2e-65 216.5 In-house 34-290 (297) alignment
Range on Protein: 3233-3489
Range on HMM: 34-290/297.0
IHREPIVFTGTASPNR---HKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKgkAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGK
   |  ....| . ..   .|.||.|..|.|. | ||  .     |||.|| |..|...   .|.|| | ..| .|||.||.... |||.||... |. |
clpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk

aMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGVPD--SAIGLLDVREQVEKWQRNSGDKPIVVHCSGGC
  | .||.|.|.. .|   ..|.|..|   .| ||...  ....  . . |||.|.|.||.| |.   ||  ||.. ..|.|   .  . |..|||. | 
.kcaryWsdkgvttfGdvsvvllsvsereGfikrelev..tkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGv

GRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTY
|||| ...    . . | |  ||.|..|. || .|| .|.  .||.| |. .||.| | || 
Grtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3247-3483 4e-65 214.9 In-house 43-276 (515) alignment
Range on Protein: 3247-3483
Range on HMM: 43-276/515.0
NRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPD--SGTQMY
| .|||| |..|.|..| ||  |     |||.|| .|....  ||.||.|||.. . |||||.|.... .||.|... .|| |  | |||||  . .  .
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GFFEITLHSMKEYPDYILREFKIVDSRDaegsSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVeKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
| ... | |..   . | |..... . |    |. | ||..  || ||||  .  || .  .| | ...    |...||| | |||| .|.    . . |
Gsikvelvsleactggikrkltvlkgdd....srtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahak

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|   ||||..|. .| .|| .|.  .|| | |  .|| |
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2912-3230 6.4e-65 214.0 In-house 4-275 (392) alignment
Range on Protein: 2912-3230
Range on HMM: 4-275/392.0
VSVGDFPAHVANMHanDDYLFSVEYPTV-EPQHHPTKdATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHS
. | .||| | . .     ||. |.  . .|. .|.. ..|...|  |||| ||  || .||||    ..| |||.|| ||.... |.|||||||| . |
ipvaqfpafveknr..hsalffeefhdlpgpdiypqt.vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

IVDFWRMIWEQKTETVVMLTNLEEKGrikchlywpppdkrvvvhgqiriqlqeelsltdytirtfslqhkVSSDERTIKQYHFTSWPDFGVPEHPTTLLR
. |||||...... |..|.|.|.|                                                 | ||. |.||| ||| .||.| ..||.
lddfwrmvfqenvttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllk

FIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLLN
||..|. .  . . |...||||||||||  |.| . . .    . .|..|||  .| .| .||||. || ||. |.|| |   .| .    . .. . |.
fikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls

EVFDKeEGKTRLEKEFDNIQ
   |  .....  ||| ...
tssdG.dvrskqlkefrslk

subfamily_CG7180_pd Subfamily CG7180 3242-3483 1.8e-64 212.2 In-house 37-290 (296) alignment
Range on Protein: 3242-3483
Range on HMM: 37-290/296.0
GTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKaMCHKYWPDSGT
|  . || |||. .|.|.|..|  |... | . |||||| ..... | |..| |..|  .| |.|||.|.....|....|... .  | |...|||  . 
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnksk

QMYGFFEITLHSMKEYPDYILREFKIVDS--------RDAEGSSQHVKQFQYVSWPS-KGVPDSAIGLLDVREQVEKWQRNS----GDKPIVVHCSGGCG
. || ... . ..|.|..   |.||..          .. .     ||.||.  |.. . || |. .|...|..|..|...       .|.||..| | .
eqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
|.| |.|    .. .. |. ||||. |. || .||..| .|..| ..|  .||..
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 3223-3483 2.2e-64 212.5 In-house 23-279 (439) alignment
Range on Protein: 3223-3483
Range on HMM: 23-279/439.0
EKEFDNIQETIHREPIVFTG-TASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIML
...|..|. |      . .  . . .. |||| .| .|| ||  |  ||||  | |||||.|.||.. | .||||||  .|.|||||.|.|.|..||.||
keifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml

ANEREGGKamchkYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDKPIVV
.|  |  |     ||| ..  .||   .      | |.|..| ||... ||     . | ||.|..|| | ||  |  .||    ..  . .    |.||
tnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvv

HCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
||| | ||||| ||  . ...||.|  ||.  .|. || ||  ||... || | |...|| .
hcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 3244-3484 3e-64 211.8 In-house 41-278 (315) alignment
Range on Protein: 3244-3484
Range on HMM: 41-278/315.0
ASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPD--SGT
 . | .|||| |..|.|..| ||  |     |||||| .|..... ||.||.||||. . |||||||...| .||.|... .|| |  | .||||  . .
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

QMYGFFEITLHSMKEYPDYILREFkivDSRDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWqRNSGDKPIVVHCSGGCGRTGTYIATCLLID
  .| ....| |..   | . |..     |..| .|. | |||.  || |||.  .  || .  .|    ... . ...|||| | ||||  |.    ..
vefGsikvellsleadtdgvarkl...vtrkse.esrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevva

RLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLG
..| .  ||||..|. || .|| .|.. ..| | | ..|| | 
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_PTPN3_pd Subfamily PTPN3 3245-3481 4.3e-64 211.1 In-house 39-273 (280) alignment
Range on Protein: 3245-3481
Range on HMM: 39-273/280.0
SPNRHKNRYANVIPFDKTRCKLSTIPGvdgsDYINANFIEGYHKG----KAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSG
. | .|||| ...|.|.|| ||.  .     ||||||...    .    . .|||||||..|. |||.||||.|||.|.||..  | |.  ||.|||...
penlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPete

T-QMYGFFEITLHSMKEYPDYILREFKIVDSRDAEgsSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwQRNSGDKPIVVHCSGGCGRTGTYIATCLL
  . || |...... .|   |.|||. . |..  |  .... |.||..|| .||||..  .|.. |.|.| .|.. ..|.|||||.| |||| .|.  . 
deleygefsvkcekedetksyvlrelvlkdketke..erkilqlqylaWpdhgvPddsadflefvervrk.lrsgkeePvvvhCsaGigrtGvlilleta

IDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
.  . ..  | . ..|| .| ||  .|....||.|  ..||.
lalieaaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2946-3191 1.5e-63 209.3 In-house 11-265 (270) alignment
Range on Protein: 2946-3191
Range on HMM: 11-265/270.0
TKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKE-NAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYW
..|  ..  ..  ||||.|    ..||.| |  . . . ||||||. |...| ..|||..||.| .. .|||||||.|....||.|.|||||| ||  ||
esdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYW

PPPDKR--VVVHGQIRIQLQEELSLTDYTIRTFSLQhkVSSDERTIKQYHFTSWPDFGVPEHPT------TLLRFIHKVQR--ENPKNAGPVVVHCSAGV
|.  |.   . .|.|..  ..|   . | ..   |.   ...|| .  .....||| |||...        ||. ...|.|  .. ..|.|..|||||||
paepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGv

GRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
|||||.|..   .. .  .| .|. . .. .|  |. .||.  || |.. |..|| |
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_PTPN23_pd Subfamily PTPN23 2955-3190 7.2e-63 207.1 In-house 43-280 (288) alignment
Range on Protein: 2955-3190
Range on HMM: 43-280/288.0
NAIKNRYANISAYDHSRVKLTedpnVPGSDYINANYIDGYKKE-NAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVV
.. |||. .|  |||.||||         ||||| .. .       .||.|.| . .. |||.|..|||....|||.. ||.|. |.. |||    . |.
yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

HGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQR----ENPKNAGPVVVHCSAGVGRTGTFITISCQIQQ
.|.... |... ..  .  |...|... ..  ....  ..||||..|||. | |||.|...|.     .. |   |.||||||||||||.|  . . ...
fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

ILDRKC-LDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
.  ..  ||| . |. .|  | ||||...|. |  .| ||. 
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

subfamily_PTPRN_pd Subfamily PTPRN 3195-3481 2e-62 205.6 In-house 4-290 (297) alignment
Range on Protein: 3195-3481
Range on HMM: 4-290/297.0
TEVSAREVKEQFRLLNEVFDKEEGKTRLEKEFDNIQETIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGY-HKGKAFI
. ||. ..     .|. . |. . |.|||||.. . .    .    .. |  | .|||...|.|.|..| ||..    . |||||| .|     .  |.|
pvvsnldistGhvvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayi

ATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEY-PDYILREFKIVDSRDAEgsSQHVKQFQYVSWPSKG
||||||..|  |||.||||. .  |..|.. .| |   |..|||| |...|...|. | | . .  ||..| | . . .  |  .. | || ..|||..|
atqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse..trtvtqfhflswpeeg

VPDSAIGLLDVREQVEKWQRNsGDKPIVVHCSGGCGRTGTYIATCLLIDRLK-TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
|| ||  ||. | .|.|  |     |||||||.|.||||.||.  |...||.     .|.   .  || ||||.|.. ||.||..... |
vPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2952-3191 2.9e-62 205.1 In-house 35-278 (287) alignment
Range on Protein: 2952-3191
Range on HMM: 35-278/287.0
HPDNAIKNRYANISAYDHSRVKLTEDPNVpGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRV
.  .. |||||..  .|..|| |.....  |||||||||. .|....|.||.|||.. .. ||||...|... .|...|   |..| ||. ||| ... .
elaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPm

VVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKV-----QRENPKNAGPVVVHCSAGVGRTGTFITISCQ
 | |   . |. .    .|..|.. | .  . . | .||... |||| ...     |.||. .|      . . ...||.|||...|.||.|.....   
rvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

IQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
... .|   .|. . |  .| .|  .||.  |. .. .||  | .
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2918-3196 7.3e-62 203.8 In-house 6-299 (301) alignment
Range on Protein: 2918-3196
Range on HMM: 6-299/301.0
PAHVANMHANDdylFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPN--VPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFW
 .|||..|.|.   |. .| ... ... . . . . .|.  ||. ||. ||. |. |.. ||  .   .||||.|||||......||.|||. . .||||
gthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfW

RMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQH-------------KVSS--DERTIKQYHFTSWPDFG
|.||..|. ..||.|||.|. . ||. |||  ...    |.. ..|..|  . |..|| ....              ||.|  . ... |.. |.||. |
rliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdG

VPEHPTTLLRFIHKV-QRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETE
|   | | |. |..| .|..  . ||||||||..|.|.|.....|  . |       |... ....|  .  .|.|  ||..|.|.. .||.. .|.
vvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty

subfamily_PTPN23_pd Subfamily PTPN23 3215-3481 9.8e-62 203.4 In-house 10-278 (288) alignment
Range on Protein: 3215-3481
Range on HMM: 10-278/288.0
KEEGKTRLEKEFDNIQETIHREPIVF-TGTASPNRHKNRYANVIPFDKTRCKLStipgVDGSDYINANFIEGYHKG-KAFIATQGPLPDTSDDFWRMVWE
. .||| |.|.| ..... ..|   . .  |  . .|||. ...|.|..| ||         ||||| |...   |   |||||.||. |. |||.||.|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

HKSSTIIMLANEREGGKAMCHKYWPDS--GTQMYGFFEITLHSMKEYPDYILREFKIVDSrDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEK-
 |||.|.|| .. | ||  ...||| .   |. .| ...||.| .| . .. |..|.    ||.   ..|.  |. |||. |||.|   ||.. ..||. 
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletl.dad.avksvshlqltsWpelGvPasPetllqfldevesa

--WQRNSGDKPIVVHCSGGCGRTGTYIA-TCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
   ...  ..|.||||| | ||||..    . ...  | .||.|. |||. || ||  ||. ..|..|.|. .||
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 3219-3491 1.1e-61 203.1 In-house 14-301 (301) alignment
Range on Protein: 3219-3491
Range on HMM: 14-301/301.0
KTRLEKEFDNIQETIHREPIVftGTASPNRHKNRYANVIPFDKTRCKLSTIPGVD--GSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSS
....|.......|. ... .|  |. . |.. ||. |. ..|. |  |.. | .|    .||||..|.|| . |.|||.|||.  |  ||||..|..| .
snkfeeqykelkegedksctv..glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

TIIMLANEREGGKAMCHKYWPDSGTQMY--GFFEITLHSMKEYPDYILREFK--IVDSRD-----------AEGSSQHVKQFQYVSWPSKGVPDSAIGLL
.|.|..|..|| |. |..|||.| .. .  |.|..||.. . |||...|...  | |. .           .. ||..| |.| ..||  ||       |
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

DVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTYAN
 | ..| . |.  |  |.||||| . .|.|.|..  . ..  | || ||||||.. .| ..||.|   .|| . |. | ..|   .||||
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2948-3201 1.4e-60 199.6 In-house 26-277 (283) alignment
Range on Protein: 2948-3201
Range on HMM: 26-277/283.0
DATQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsDYINANYID---GYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYW
| .   .|  |||. .| ..|  ||.|  ...    ||||| .|     ||... ||..|.|. . .||||.|....|  ..||||.| |  ||||  ||
diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

PppDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSS-DERTIKQYHFTSWPDFGVPEHPTTLLRF--IHKVQRENPKnaGPVVVHCSAGVGRTGTFI
|   .  . .|.  . |..| .   ..|. . |... |. ..  .  | .  | ..|      .|..|  .   |.|..|  ||.|||||.|.|||..||
P..krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskk..gPivvhCstgiGrtavfi

TISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSARE
..|. ....|    .|... |. || .|  .|||  || ..|.. ||   ||.|.. | .
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavd

subfamily_PTPN14_pd Subfamily PTPN14 2934-3191 4.2e-59 195.0 In-house 27-297 (300) alignment
Range on Protein: 2934-3191
Range on HMM: 27-297/300.0
VEYPTVEPQH-HPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVpGSDYINANYIDGY--KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLT
.||  . ... . . .... |.|| |||. ..  |...||.|.   .   ..||||  |      ||  ||..|||... . |||.|.|||... .||||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NLEEKGRIKCHLYWPPP--DKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQR----EN----P
. ||.|. |.. |.|     |. | .|. ... .   . . .. ... |.|  |..|||.    .| ||| |||| ... | ....||      |    .
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

K-NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
| .  ||.|||||||||||  |.    |. .   . .|| . .. .| .| ..||| ||| |....|..||.
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_PTPRN_pd Subfamily PTPRN 2945-3188 8e-59 193.8 In-house 46-290 (297) alignment
Range on Protein: 2945-3188
Range on HMM: 46-290/297.0
PTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYI-DGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLY
 ||.......|. |||.... .||||||||.|. .   ||||||  | |   .. ||||.|||..... |||.|.||| .  .|.||.|||.|  .|. |
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPppDKRVVVHGQIRIQLQ-EELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFIT
||  |.   |..   ..|  | .   || .|.| |.   .|. ||. |.|| |||. |||  . .|| |  ||..     . |.|||||.|.||||..| 
wp..deGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyil

ISCQIQQILD-RKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLE
|   ....|   | .||   .. .| .|  .|.|..|. |.  |. |
idlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 3243-3488 3e-58 192.0 In-house 29-271 (283) alignment
Range on Protein: 3243-3488
Range on HMM: 29-271/283.0
TASPNRHKNRYANVIPFDKTRCKLSTIPGvdgsDYINANFIE---GYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDS
.|. |..|||. ...| |. | .| . .     ||||| ||     |...| .|..|.|| .|  |||.||...| ..|.||.. .|. .  | .|||  
sadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr

GTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQhVKQFQYVSWPSKGvPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLL
|.. || | .||.       .| .|. .  .  |. .   .  .|.. | . | ... |  |   ..|   |..| . ||||||| | |||...||    
GsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasas

IDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDT
.. ..|| .||||.||. .| ||...|.. ||| . .. .||     ||
vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdt

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 3245-3483 1.9e-57 189.3 In-house 18-264 (270) alignment
Range on Protein: 3245-3483
Range on HMM: 18-264/270.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHK-GKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQ-
  ... ||||...|  .|| .|...   . . |||||...|...  |..||..|||| |  .||||.||.|...|.|...  | |.  | .||| .  . 
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

---MYGFFEITLHSMKEYPDYILREFKIVdsrdAEGSSQHVKQFQYVSWPSKGVPDSAI------GLLDVREQVEKWQRNSGDK-PIVVHCSGGCGRTGT
   ..|. ...  | .    |||.. ..      .|.....  |.|..|| .||| ..        || . ..| .....  .. |..|||| | |||||
vkledgkikvlalseekeegyiltrlrle....ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

YIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
 ||.   .  |.... ||| .... || .|. .|. ..|||| ||...|. 
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

0051429 (Phosphotyrosine protein) phosphatases II 2980-3213 1.9e-56 186.9 In-house 1-247 (272) alignment
Range on Protein: 2980-3213
Range on HMM: 1-247/272.0
VPGSDYINANYIDGYKK---ENAYIASQGPVPHSIVDFWRMiWEQKTETVVMLTNLEEKGRIKCHLYWP----------PPDKRVVVHGQIRIQLQEELS
.| |.||||....|| .   ......|.|| |... ||||. .|..  |.|.|...||.|| ||..|||          . .   . .|..|. |..|  
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LTDYTIRTFSLQHK-VSSDERTIKQYHFTSWPDFGVPEHPttLLRFIHKVQRenpknAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLD--------
|.||..|.. | ..   .. |.. ..|.|.|||.|||...  ||.... ...      |||.||||||..||||.. .   .... .   .|        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYlECGETEVSAREVKEQFRLLNEVF
....|. .| .|  .||||.||.|...||||.  .. ..|.|. ..  .. ..| .
leeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaideey

0041856 (Phosphotyrosine protein) phosphatases II 2955-3196 3.4e-54 178.5 In-house 1-177 (182) alignment
Range on Protein: 2955-3196
Range on HMM: 1-177/182.0
NAIKNRYANISAYDHSRvkltedpnvpGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTnleekgrikCHLYWPppdkrvvvh
|  |||| .|  |||||          ..||||||...|. . . .|| ||| .... ||.||..|..  |.|.||         ..||||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gqiriqlqeelsltdytirtfslqhkvSSDERTIKQYHFTSWPDFGVPEhPTTLLRFIHKVQRenpkNAGPVVVHCSAGVGRTGTFITISCQIQQildrk
                           .  ||.. ||....|||.|||. . .||.||..|..    . |||.||||||||||||.. .   ...     
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

CLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETE
 ..... |. .| ||. ||.|. ||.|...||||.|....|.
gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3247-3481 3.5e-54 178.5 In-house 7-238 (239) alignment
Range on Protein: 3247-3481
Range on HMM: 7-238/239.0
NRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHK-GKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSgTQMYG
|. ||||||.. .|..|  |  .     ||||||...  |    ||.||||| .  .| |||||.|. .   |.||.   || |  ||.||||| |  | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

FFEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKT
 . .||.  . . |||.| | .  |.  .   ..| |...  || ||||. |  .| .| .. | .   | .| |.||| | ||||...    .. . | 
nlrvtlrktevfadyiirtfvm..sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

EGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
.  ||.|. |. .| .|| ||.. .|| | . ..||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3247-3481 4.5e-54 178.1 In-house 8-239 (239) alignment
Range on Protein: 3247-3481
Range on HMM: 8-239/239.0
NRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHK-GKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSgTQMYG
|. ||||||.. .|..|  |  .     ||||||...  |    ||.||||| .  .| |||||.|. .   |.||.   || |  ||.||||| |  | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

FFEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKT
 . .||.  . . |||.| | .  |.  .   ..| |...  || ||||. |  .| .| .. | .   | .| |.||| | ||||...    .. . | 
nlrvtlrktevfadyiirtfvm..sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

EGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
.  ||.|. |. .| .|| ||.. .|| | . ..||
qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 3247-3481 1.4e-53 176.5 In-house 3-237 (237) alignment
Range on Protein: 3247-3481
Range on HMM: 3-237/237.0
NRHKNRYANVIPFDKTRCKLSTiPGVdGSDYINANFIEGYHK-GKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSG-TQMY
|. ||||.|.. .|..|  |   .|  |||||||....|.    | .||.||||  . ||||.|||. | | |.||.   || .  ||||||..   . |
nkiknrygnivaydhsrvvlkg.ags.gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GFFEITLHSMKEYPDYILREFKIVDSRDAEgSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN-SGDKPIVVHCSGGCGRTGTYIATCLLIDRL
| . ..|.  .|. || .| . ..     .   . ..|.|. ||| .|||. .  ||  | .. .  .  |   | ..||| | |||| ..    .. . 
gvltvslkkkeefsdytvrslllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
| . .||... |  .  .|| .... ||| | ...|||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_PTPN14_pd Subfamily PTPN14 3214-3483 1.5e-53 176.7 In-house 17-296 (300) alignment
Range on Protein: 3214-3483
Range on HMM: 17-296/300.0
DKEEGKTRLEKEFDNIQETIHrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVdGSDYINANFIEGYHKG--KAFIATQGPLPDTSDDFWRMVW
.|.  .... .|...|..  . . .. |..   | .|||. .|.|....| .||.      ..||||  |.    |  . .|..||||. |  |||.|||
ekkleegkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvW

EHKSSTIIMLANEREGGKAMCHKYWPDS----GTQMYGFFEITLHSMKEYPDYILREFKIVDSRdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQV
|.. . |.||..|.|.||  ..||.|..     |  .| |..| .  .. . .| . .|.       .  . |  .||. || .|||.   | |.  |.|
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp..skeertvwhlqytDWpdhgvPeDvkgflsyLeev

EKWQRNS--------GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.  .|..         . |..|||| | ||||  | . |||  |...  .|. .|.. || ||  .|... ||.| || ....|
qsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_CG7180_pd Subfamily CG7180 2952-3194 5.6e-53 174.5 In-house 39-294 (296) alignment
Range on Protein: 2952-3194
Range on HMM: 39-294/296.0
HPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRiKCHLYWPPPDkrV
. .|  |||. ..  ||. || |..      |||||| |.|.. |...||  ..|. ... .|||.........||.||.  .  . ... |||.     
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..k

VVHGQIRIQLQEELSLTDYTIRTFSLQHK----------VSSDERTIKQYHFTSWPD-FGVPEHPTTLLRFIHKVQRENPKN-----AGPVVVHCSAGVG
  .|.| ... || .... .|||| |..|          |. ..|..|....| |.    ||   ..|. ....|.    |.      |||||..| |..
eqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGE
|.| ...|   ....   ...|....|. .|  |  .|..  .| .| | |||.. |. 
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

subfamily_PTPN1_pd Subfamily PTPN1 3223-3481 3.5e-52 171.9 In-house 5-269 (290) alignment
Range on Protein: 3223-3481
Range on HMM: 5-269/290.0
EKEFDNIQETIHREPIVFTG---TASPNRHKNRYANVIPFDKTRCKLSTIPGvdgsDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTII
.. ...| ..|..|   |.        || .||| .| |.|..| ||         |||||...|  .  . .| ||||||.| | ||.||||.|| ...
krlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

MLANEREGGKAMCHKYWPDSGT--QM-YG--FFEITLHSMKEYPDYILREFKIVDSRDAEgsSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRN-
|| .  | ..  |..|||      .. .    ....| | ...  |..| ... . .  |  .... .| |..||  |||.|   .|.   .| .     
mlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqe..treilhfhyttwpdfgvpespaaflkflfkvresGsls

SGDKPIVVHCSGGCGRTGTY--IATCL-LIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
|   | |.||| | ||.||.  . ||| ||.. .    ||. .|.  || .| |...  || .| | .|||
sdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2953-3190 9.4e-52 170.9 In-house 39-277 (307) alignment
Range on Protein: 2953-3190
Range on HMM: 39-277/307.0
PDNAIKNRYANISAYDHSRVKLTEDPNvpGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVV
  |. |||| .. . |..|. .. |     |||| |||.    | . .|..|||   .. .|| |. ..| |.|.|| .. | ..|||. |||  . .  
santdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

VHGQI--RIQL----QEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFITISCQ
|.|.    | .     ..|.  .  |   .|. . ... |||... .. ||| |||.   | . ... |.     .  ||||||||||||.|| ..||  
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvvvhcsaGvGrsGtivaislv

IQQIL-DRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
 ....    | |. ..|. .| .| . .||||||...|  ||||.
qdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2954-3189 1.7e-51 169.6 In-house 53-282 (290) alignment
Range on Protein: 2954-3189
Range on HMM: 53-282/290.0
DN--AIKNRYANISAYDHSRVKLTEDpnVPGsDYINANYIDGYKkeNAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRV
 |    |||| ..   | .|| | .    .| ||. |||..| |    .| .||..  ...|.|||. ..|. ..||| .| |.|. ||. |.|  . .|
kntefkknrykdvvcndktrvilkdG..ydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

VVHGQIRIQLQEELSLTDYT-IRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFITISCQIQQI
.  |.| .   || .  . .  .|.|...| |  |  .| ..  ||||  |.    .||| .. ..    | .||||||||||.||||||..|   .| .
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr....kasGpvvvhcsaGiGrtGtfvaievglqil

LDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEY
|| | ||. . |...|  |   || . ||. . ..||..
ldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

0051429 (Phosphotyrosine protein) phosphatases II 3273-3485 3.3e-51 169.8 In-house 2-227 (272) alignment
Range on Protein: 3273-3485
Range on HMM: 2-227/272.0
DGSDYINANFIEGYHK---GKAFIATQGPLPDTSDDFWRMvWEHKSSTIIMLANEREGGKAMCHKYWP------------DSGTQMYGFFEITLHSMKEY
. |.||||... ||..    .......|||| | .||||. .|.. .||..| .| | |.  |..|||            .  |  ||.. .||.|.. .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PDYILREFKIVDSRDAEGSsQHVKQFQYVSWPSKGVPDSAigLLDVREQVEKwqrnsgDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVD-------
.||||||. ..   .|. .  .| ...| .||  |||..|  ||.. |.. .      ..|..||||.|..||||..|  ||. ..  |  ||       
ldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGS
 ....|. || ||||.| . .||.|.|. .||.| |
yleeaveelraqrpgavqteeqylflyeallellrs

0036282 (Phosphotyrosine protein) phosphatases II 3274-3477 7.7e-51 167.5 In-house 1-164 (174) alignment
Range on Protein: 3274-3477
Range on HMM: 1-164/174.0
GSDYINANFIEGYHKGKAFIATQGPLPdtsddFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDsgtqmygffeitlhsmkeypdyilrefkivdsrDA
|||||||... ...  . .||.||||.     ||.|..|....|..|| .|.| |. .|. |||.                                 . 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

EGSSQHVKQFQYVSWPSKGVPDSAIgLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKtEGLVDVFQVVRGLRLQRPGMVRSVDQYE
|  .... |..|. ||  ||||..| ||.. ..||... .....|..||||.|.||||| .|  |.. .|. |.|||....|| ||||||||| . .||.
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FCYK
|.|.
flyy

0041856 (Phosphotyrosine protein) phosphatases II 3247-3483 1.2e-49 163.7 In-house 1-171 (182) alignment
Range on Protein: 3247-3483
Range on HMM: 1-171/182.0
NRHKNRYANVIPFDKTRcklstipgvdGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLAnereggkamCHKYWPdsgtqmygf
|..|||| ...|.| .|          ..||||||.. |..... ||||||||..|  ||.||..|.. .||..|.         .. |||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

feitlhsmkeypdyilrefkivdsrdaEGSSQHVKQFQYVSWPSKGVPDsAIGLLDVREQVEKwqrnsGDKPIVVHCSGGCGRTGTYIATCLLIDRlkte
                           |   ... |..|..||  ||||    |||  |.|..      ..|..||||.|.|||||..|  |.. .    
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....

GlVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
| |.....|. .| .||||| . .|| |..  .||.|
g.vsleeavklvrsrRpgmvitpnqyfflqlallell

0036282 (Phosphotyrosine protein) phosphatases II 2982-3184 1.6e-49 163.3 In-house 1-164 (174) alignment
Range on Protein: 2982-3184
Range on HMM: 1-164/174.0
GSDYINANYIDGYKKENAYIASQGPVPhsivdFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPpdkrvvvhgqiriqlqeelsltdytirtfslqhKV
|||||||...|..   . .||.||| .     ||.|..|.. .|||||....|.|. ||. |||                                  . 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

SSDERTIKQYHFTSWPDFGVPEHPTtLLRFIHKVQRENPK-NAGPVVVHCSAGVGRTGTFITISCQIQQILdRKCLDIYNFVQSMRYRRCFMVQTEAQYI
.. ||.. ||... |||.|||. .. ||.|.  |..   . . |||.||||||||||||.. .   ....|  .  |....|...|. |. ||||. ||.
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

FIHD
|...
flyy

0049772 (Phosphotyrosine protein) phosphatases II 3221-3483 6e-48 159.5 In-house 20-280 (314) alignment
Range on Protein: 3221-3483
Range on HMM: 20-280/314.0
RLEKEFDNIQETIHREPIVFTGTASPNRHKNRYANVIPFDkTRCKLsTIPGVDGSDYINANFIEGYhkgKAFIATQGPLPDTSDDF----------WRMV
.|. ...... .. .| .. ..   .||.|||| ...|.| .| .|    .|.|||||||... |.   ..||||||||. | .||          ||||
klllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmv

--WEHKSSTIIM---------------------LANEREGGkamchKYWPDSGTQMYGffeitlhsmkeypdY-------IlrefkivdsrdaegsSQHV
  ..... .| |                     | .  ..|      ... .  ...                                       ....
lrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk..............eelydpelf...............erlg

KQFQYVSWPSkGVPDSAIGLLDVREQVEKWqrnSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKteglVDVFQVVRGLRLQRP-----GMVRSVDQYEFC
 .. .. .|  | ...   .... | .|..   . ..|..|||..|.|||||......|. .|.    |.. .... .||.||     |.... .||||.
ikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefi

YKSILEFL
.. .||.|
lealleyl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 3245-3483 1.4e-47 156.9 In-house 43-236 (392) alignment
Range on Protein: 3245-3483
Range on HMM: 43-236/392.0
SPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGkamchkywpdsgtqmy
  | .|||| |..|.|..| ||  |  .  |||.|| .|....  ||.||.||| . . |||||||.... .||.|... .||                 
einlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd................

gffeitlhsmkeypdyilrefkivdsrdAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVeKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
                               . . | ||... || |.||  .  || . ..| | .  .  .|...||| | ||||  |.   .. . |
............................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisidsvvahak

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.  .||||..|  .| .|| ||.. .|| | | ..|| |
ktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl

0049772 (Phosphotyrosine protein) phosphatases II 2948-3195 9.3e-46 152.3 In-house 39-285 (314) alignment
Range on Protein: 2948-3195
Range on HMM: 39-285/314.0
DATQHPDNAIKNRYANISAYDhSRVKLtEDPNVPGSDYINANYIDGYkkeNAYIASQGPVPHSIVDF----------WRMI--WEQKTETVVM-------
 . ... |  |||| .|  .| .||.|    .| |||||||.|.||.   ...||.||| .. .|||          |||.  ..... ..||       
lvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LTNLEEKGrikchlywpppdkrvvV----------HgqiriqlqeelsltD-------YtirtfslqhkvssdERTIKQYHFTSWP
              |..| ..|                           .              .       .              ||.. .|. . .|
delsrLdaAlgKtpllildgng................neptaadlellk..............eelydpelf..............erlgikylripvp

DFGVPeHPTTLLRFIHKVQREnpKNAGPVVVHCSAGVGRTGTFITISCqiqqILDRKCLDIYNFVQSMRYRRC-----FMVQTEAQYIFIHDALLEYLEC
|...|  .  ...|.. ...   .. |||.|||.||.||||||... .    .. .  ...   .. .| .|       ....  ||.||..||||||. 
Dgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaay....lmkllgvsleealedvrlkRpinpnpgfieqleqyefilealleylkf

GET
 ..
lkk

0046846 (Phosphotyrosine protein) phosphatases II 2977-3191 1.1e-45 150.8 In-house 6-174 (176) alignment
Range on Protein: 2977-3191
Range on HMM: 6-174/176.0
DPNVPGSDYINANYIDGYKkenaYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVvhgqiriqlqeelsltdytirtfs
.   ...||||||.|.|..    .|| |||.|... ||..|..|.. ..||.||.. |.||.||. |||   |  .                        
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lqhkvssdertikQYHFTSWPDFGVPEHpTTLLRFIHKVQRENPKNaGPVVVHCSAGVGRTGTFITIScqiqQILDRKCLDIYNFVQSMRYRRC-FMVQT
             ||... |||.|||.. . ||...  ...   .. |||.||||||.|||||.. .      .  .|.|.... .. .| .|. ..|||
.............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

EAQYIFIHDALLEYLE
..|| |.....|..|.
peQyrflyefellllk

0043147 (Phosphotyrosine protein) phosphatases II 2981-3183 2.9e-45 149.4 In-house 3-154 (172) alignment
Range on Protein: 2981-3183
Range on HMM: 3-154/172.0
PGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLeekgrikchlywpppdkrvvvhgqiriqlqeelsltdytirtfslQHK
.|||||||.|.|.| . . .|| ||| .. . |||||..|..  ..|.||.|                                             .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

VSSDERTIKQYHFTSWPDFGVPeHPTTLLRFIHKVQR-ENPKNAGPVVVHCSAGVGRTGTFITISCQIqqildrKCLDIYNFVQSMRYRRCFMVQTEAQY
 .  ||.. ||....|||.||| ..  ||.|.. ...  . .. |||.||||||||||||.. .   .      ..|.... |. .| .|. .||.. ||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

IFIH
.|..
rfly

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2953-3191 3.6e-45 149.1 In-house 31-260 (267) alignment
Range on Protein: 2953-3191
Range on HMM: 31-260/267.0
PDNAIKNRYANISAYDHSRVKLTEDPNVpgsdYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEkGRIkcHLYWPPPDKRVV
 .|. .||. .   ||..|| | .  .     |||| |..|||..||.|. |.|.  .| ||. .| .||  ..|.||.  . . |  .|.|||   .  
eknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.dni..rlfwPPkmgqak

VHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDErTIKQYHFTSWpDFGVPEHP--TTLLRFIHKVQRENPknAGPVVVHCSAGVGRTGTFITISCQIQQI
 . .. ..   |    || | |. |. |  |    .  |..  | .  . ..|    |.  . | | ||     |.||.||.||||.|||..|  |....
kyqdltvehslekeendyqiitlelkfknesah.nvtlyyykkw.nintnnkpylkplfgilaknqleng..nrPlvvacsdGvGrsGtflvidsqlera

LDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
     .||..|.. .| .|  .|.|  .||.||. | || |
ktegvsdifdflrkirsqriglvdtkeryiyihellaeyae

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 3216-3482 2.7e-44 146.2 In-house 2-258 (267) alignment
Range on Protein: 3216-3482
Range on HMM: 2-258/267.0
EEGKTRLEKEFDNIQETIHREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTipgvDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKS
|. .. .||||..|..  . .  . .  |. |. .||. ...|.|.||  |.|       .|||| ..|||....|||.||.||  |  ||. .. ..| 
edeeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkv

STIIMLANEREGgkaMCHKYWPDSGTQMYGFFEITL-HS-MKEYPDYILREFKIvdsRDAEGSSQHVKQFQYVSWPSKGVPDSAigLLDVREQVEKWQRN
..|..| .  ..     ...||    |   . ..|. ||  ||  || .  ...   .  . |.. |  . |  |  .        |  .   . | | .
pvivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfknesahnvtlyyykkwnintnnkpy..lkplfgilaknqle

SGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
 |..|.||.|| | ||.||..     ..|.|||| .|.|. .| .| ||.|.| . ..| ...... |.
ngnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2948-3190 1.4e-43 143.6 In-house 47-289 (305) alignment
Range on Protein: 2948-3190
Range on HMM: 47-289/305.0
DATQHPDNA-IKNRYANISAYDHSRVKLTEDPnvpGSDYINANYIDGY-KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWP
.| | .| |  ||||... . |.| ||| . .    |||| |||.      |. .|..|||. ..| .|| |. ..| | .||| .  | |..||  |||
nanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywp

PP--DKRVVVHGQIRIQLQEELSL-TDYTIRTFSLQHKVSSDE-RTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRenpkNAGPVVVHCSAGVGRTGTFI
    .|. .  | .  ..     .  |  |.   |.   | |.  .... ..| ||| |||    | | ..  ..        |.|||||||.||||| .
aaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtiv

TISCQIQQILDR-KCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYL
.|   ...| .  .|  . ..|...| .|.| .|.. ||.|||  .|.|.
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2952-3191 1.7e-43 143.5 In-house 45-288 (305) alignment
Range on Protein: 2952-3191
Range on HMM: 45-288/305.0
HPDNAIKNRYANISAYDHSRVKLteDPNVPgSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRV
. ..| |||| ..   |. ||||  ..  |  .|| |||.    . . .| .| |. ..  ||| | ...| |.. || || |||  ||. |..  || |
eaqeagknrykdvgcldnnrvkl..egpwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

VVH--GQIRIQLQEELSLT-------DYTIRT-FSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFI
.    .. .|... | | |       . ...    .     .. | ...||.  ||| |||   ...| ...| .       ||.|||||||.||||. .
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtgsvv

TISCQIQQILDRKCLD-IYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
 .   ..|.|  . ..     .| .| .|   .||.|||.|.|. .|.|..
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

0043147 (Phosphotyrosine protein) phosphatases II 3273-3476 5.7e-43 142.0 In-house 3-154 (172) alignment
Range on Protein: 3273-3476
Range on HMM: 3-154/172.0
DGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEreggkamchkywpdsgtqmygffeitlhsmkeypdyilrefkivdSRD
.|||||||.....|.. . ||||||||. | .|||||..|.. ..|..| ..                                               |
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

AEGSSQHVKQFQYVSWPSKGVPdSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIdrlktEGLvDVFQVVRGLRLQRPGMVRSVDQY
.|. .... |..|..||  ||| ..  ||.. |...... .| ..|..||||.|.||||| .|  |..     .|| .....|. .| .|||.| . .||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqy

EFCY
 |.|
rfly

0049260 (Phosphotyrosine protein) phosphatases II 2990-3184 2.4e-42 139.5 In-house 1-144 (152) alignment
Range on Protein: 2990-3184
Range on HMM: 1-144/152.0
YIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWpppdkrvvvhgqiriqlqeelsltdytirtfslqhkvssdertik
.||||.. ...|| ||| |... |||||..|..  |.||||.|.|.|..||. |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIqqildrKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHD
||... |||.|||...  || ... ... . .. |||.||||||||||||.. .   .      . ......|. .| .|  .|... |..|...
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2949-3189 3.4e-42 139.0 In-house 31-268 (281) alignment
Range on Protein: 2949-3189
Range on HMM: 31-268/281.0
ATQHPDNAIKNRYANISAYDHSRVKLTE-DPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPP
. ..| |  ||||.|| . | |||.|    ||   .||| ||||     .  || .|||   .  |||||||...| ..||| .. |  | ||  |.|  
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

DKRVVVHGQIRIQlqEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRenpkNAGPVVVHCSAGVGRTGTFITISCQI
 . ..   .. ..   | |  . .. |  |.     . | | .. .  |||. |||    .|. ..|..      . | |.||||||||.||....   .
ahcclqfdklsvs..yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira....rstppvihcsagvgrsgtlmaveial

QQILDRKCL-DIYNFVQSMRY-RRCFMVQTEAQYIFIHDALLEY
| |  .  | || . |  .|   |.  |||  ||..|   ||..
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 3245-3482 6.4e-42 138.2 In-house 54-282 (290) alignment
Range on Protein: 3245-3482
Range on HMM: 54-282/290.0
SPNRHKNRYANVIPFDKTRCKLSTipGVDGsDYINANFIEGYHkgKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMY
 .. .|||| .|.  ||||  |.   | || ||. ||...| .    || |||.| ||  |.|||| ..| ..|.|| .  | ||| |..|.|.   .. 
ntefkknrykdvvcndktrvilkd..GydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl

GFFEITLHSMK-EYPDYILrEFKIVDSRDA-EGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrNSGdkPIVVHCSGGCGRTGTYIATCLLIDR
 | |||.   . . .|  .   |..  ||  .| .  .| .. .||| | |. |.. || .   . |    ||  |.||||| | |||||..|    .. 
tfGeitvlcseeddkdani.ikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk...asG..pvvvhcsaGiGrtGtfvaievglqi

LKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
|     .|. ..|| ||  | . |.   ||    . .|..
lldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_ptpA1_pd Subfamily ptpA1 2951-3148 8e-42 138.4 In-house 43-254 (418) alignment
Range on Protein: 2951-3148
Range on HMM: 43-254/418.0
QHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKeNAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPP--D
..  |. ||||.||   .|.||.| .  .  ||||||||||||    . .|..|||.| .| |||||.||..   .|||.   |. ||||  |||     
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

-------KRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQ-REN---P--KNAGPVVVHCSAGVG
       .   | |   ..| | .   .  | |  ..  .  . | | ||..  |||. .|.|   . ...| .  |.|   |      |..||||||||
eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGTFITISCQIQ
||||| |    ..
rtgtfctavimmk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 3219-3481 1.2e-41 137.6 In-house 6-293 (297) alignment
Range on Protein: 3219-3481
Range on HMM: 6-293/297.0
KTRLEKEFDNIQETihREPIVFTGTASPNR-HKNRYANVIPFDKTRCKLSTipGVDGSDYINANFIEGYHK--GKAFIATQGPLPDTSDDFWRMVWEHKS
.  ||.| | . .   ...  |. .  ..  .|||| ... .|.|| ||    .. ..|||||...   ..     .| .|||| .| ||||..|.|.  
rkeleaekdlllde..argesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdv

STIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLH----SMKEYPDYILREFKIVDSrdaeGSSQHVKQFQYVSWPSKGVP----D--S---------
 .|.|.|. .|.|.  |  |||..  .     .. .        |.   || |....        |..|.  |..||| .|||    |            
rvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscc

-----AIGLLD-----VREQVEKWQRNS-GDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
      ..|..     |  |.|  . .   . ...|||| | ||.|  . .  ....|. . . ||  ... || ||. .|....|.|..|. .|.
iavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

0046846 (Phosphotyrosine protein) phosphatases II 3273-3483 1.6e-41 137.3 In-house 10-173 (176) alignment
Range on Protein: 3273-3483
Range on HMM: 10-173/176.0
DGSDYINANFIEGYHkgkaFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDsgT--QMYgffeitlhsmkeypdyilrefkivds
 ..||||||.| |..    .||||||||.|  ||..|..|.. .....| .|.| |.  |. |||.       .                          
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..........................

rdaegssqhvkQFQYVSWPSKGVPDSaIGLLDVREQVEKWQRNSgdKPIVVHCSGGCGRTGTYIAtCLlidRLKTEGLVDVFQVVRGLRLQRP-GMVRSV
           |.... ||  ||||.   ||.. |........   .|..||||.|.|||||..| ..    |..|  ..|..... .| ||| |.| . 
...........qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlva.ay...llelekglsveealalvreqRplgavqtp

DQYEFCYKSILEFL
.||.|.|. .|..|
eQyrflyefellll

0044763 (Phosphotyrosine protein) phosphatases II 2967-3193 1.4e-40 134.1 In-house 2-174 (178) alignment
Range on Protein: 2967-3193
Range on HMM: 2-174/178.0
YDHSRVKLTEDPNVPGSDYINANYIDGYkkenAYIASQGPvphsiVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKrvvvhgqiriqlqeels
.|..||.|.. .....||||||..|...     |..|..|     .|......|..  ..|.||.  | |..||. |||                     
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

ltdytirtfslqhkvssdertiKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGRTGTFITISCQIQQildrkCLDIYNFVQSMR
                       ||... .||.|||. .  .|.|.. ...  ... |||.|||||||||.||.. .   ...      |.... .. .|
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

YRRCfMVQTEAQYIFIHDALLEYLECG
 ||. .|... |. ....  |..|. .
erRp.ivpnpgqlrqLyefelrllkes

0049260 (Phosphotyrosine protein) phosphatases II 3282-3477 2.1e-40 133.2 In-house 1-144 (152) alignment
Range on Protein: 3282-3477
Range on HMM: 1-144/152.0
FIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWpdsgtqmygffeitlhsmkeypdyilrefkivdsrdaegssqhvk
||.||.....|||||||.| | .|||||..|.. .||.|| .. | ||  |..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QFQYVSWPSKGVPDSAIGLLDVREQVEKWqRNSGDKPIVVHCSGGCGRTGTYIATCLLIdrlkteGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYK
|.... ||  ||||... ||.. . .||. . . ..|..||||.|.|||||..|  |..        |.....|. .| .|||.| . .|..|.|.
qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_ptpA1_pd Subfamily ptpA1 3223-3443 2.3e-40 133.6 In-house 24-256 (418) alignment
Range on Protein: 3223-3443
Range on HMM: 24-256/418.0
EKEFDNIQETIHREPiVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHkGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLA
..||  ..|..        |    |  ||||.|..| ..|| .|  |   .||||||||.|.| .  | ||.||||||.|  |||||||| .   |.||.
keefrlleesvgpse.tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmls

NEREGGKAMCHKYWPDS-----------GTQMYGFFEITLHSMKEYPDyilREFKIVDSR-DAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKW
 | |  .  | .|||.            | ...| . . |  . . |.   ||    . |   || .. . |.||  || . .|| .  . ..   . . 
resencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe...reiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnr

QRN---SGD--KPIVVHCSGGCGRTGTYIATCLLIDRL
| .   | |   ||.|||| | |||||. .. ... .|
qnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2941-3192 2.4e-40 133.4 In-house 29-273 (288) alignment
Range on Protein: 2941-3192
Range on HMM: 29-273/288.0
PQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVpgsdYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKC
|.. . . .... .|. ..|| |.   | .||||..||.     ||.|| .   | ..  | .| |.   |  .|.|. |.  | .|||..| |||. | 
pneasidiidsfianptrdryenlprcditrvklsddpdf....yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeks

HLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERT-IKQYHFTSWPDFGVPEHPTTLLRFIHKVqrenPKNAGPVVVHCSAGVGRTGT
  |.|    . .  |..  . ... .  | ...   |. .   .|.  .|. |.  |.| ||||   . ||... .     .   |.|||.|||||||||
aeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgt

FITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLEC
.| |   ....     | | ......|  |   .||| ||...|  .||.|  
lililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 3220-3483 7.9e-40 131.7 In-house 16-277 (307) alignment
Range on Protein: 3220-3483
Range on HMM: 16-277/307.0
TRLEKEFDNIqetIHREPI-VFTGTASPNRHKNRYANVIPFDKTRCKLsTIPGVdGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTI
..|  || ..    ...|  | . . | | .|||| .|   ||.|  . ...|.  |||| ||..    | | ||..|||| .|  .|| |. ..|  ..
qalvdefrvl...akktpegvtveafsantdknryqdvkcqdkgrivv.kfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

IMLANEREGGKAMCHKYWPDSGTQMYGFFE----IT---LHSMKEYPDYILREFKIVDSRDAeGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwq
|||..  | .|  |..|||    |   | |    |.   | . |  ||  | .   ..   | . |. ....|.  || .|||.  .. ... | |    
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqinltainlleav....

rNSGDKPIVVHCSGGCGRTGTYIATCLLIDRL-KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
 .    |.||||| | ||.|| .| .|. |.. . .   |. ..|. || ||.  ...  || . .. .||..
.rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2950-3195 2.1e-38 126.9 In-house 30-274 (285) alignment
Range on Protein: 2950-3195
Range on HMM: 30-274/285.0
TQHPDNAIKNRYANISAYDHSRVKLTEDpnvpGSDYINANYIDGY-KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPD
| .  |   ||||.. . . .|| | .       ||| |...    | ...||..|||.| .. |||.||...|   |.||  | | |  || ||.|   
tayeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

KRVVVHGQIRIQLQE----ELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAgPVVVHCSAGVGRTGTFITIS
  ||  |.  | | |     .. | .   |       ||.   ... .   |||   ||    .. . . |.. |||.  |..|||||||||| ||. | 
gevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgid

CQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLeCGET
    .|..   ... . |. ||  |   ||.  |..|..  |.||.  || 
yatirimenpniemldivremramrfqavqshmqflflyvvlmeyf.igeg

0051082 (Phosphotyrosine protein) phosphatases II 2982-3187 2.8e-38 126.2 In-house 2-150 (151) alignment
Range on Protein: 2982-3187
Range on HMM: 2-150/151.0
GSDYINANYIDGYkkenaYIASQGPVPhsivDFWRMIWEQKTETVVMLTNLEEKGriKCHLYWPPPDkrvvvhgqiriqlqeelsltdytirtfslqhkv
 |||||..|..|.     ...|.|| .    ||.....|..  |.|.|...|| |  .|. |.|  .                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ssdeRTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRenpKNAGPVVVHCSAGVGRTGTFITISCQIQQildrkcLDIYNFVQSMRYRRCFMVQTEAQYIF
    ..........|||.|.|... ..|.|......   |. |||.||||||.|||||.. . . ...      ....  .. .| .|. .||.. |..|
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

IHDALL
.. |||
qlfall

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2952-3200 7.7e-38 124.8 In-house 49-299 (310) alignment
Range on Protein: 2952-3200
Range on HMM: 49-299/310.0
HPDNAIKNRYANISAYDHSRVKLTEDPNVpGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDkRV
. ..  ||||...   | |||||. |      ||| |||.      ...| ||||. |.|.||||||.....|....| .  |.|| ||  |||      
ykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg.vt

VVHGQIRIQLQEELSlTDYTIRTFS---LQHKVSSDERT-------IKQYHFTSWPDFGVPEHPT--TLLRFIHKVQRenpknaGPVVVHCSAGVGRTGT
  .| ||.    | |  .. |  ..   .  .|  ||.        ..  ..  ||| |||.        |.. .|.       ||.|||||||..|...
etygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh......gpcvvhcsagkdrlyv

FITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYlECGETEVSAR
 ...  .|...   . .|. . .  .. .|   .||| ||..|.   . .   |||||. .
vvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif.argetevaek

PTPc_DSPc_SM00012 3087-3188 1.8e-36 119.9 In-house 1-105 (105) alignment
Range on Protein: 3087-3188
Range on HMM: 1-105/105.0
TIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNA--GPVVVHCSAGVGRTGTFITISCQIQQILDR-KCLDIYNFVQSMRYRRCFMVQTEAQYIFIH
|.|.||.|.|||.||||... .|.....|.... |..  .||||||||||||||||..... .||. .. |..||...|...| .|  |||||.||.|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

DALLE
.||||
ralle

0051082 (Phosphotyrosine protein) phosphatases II 3275-3480 6.3e-36 118.6 In-house 3-150 (151) alignment
Range on Protein: 3275-3480
Range on HMM: 3-150/151.0
SDYINANFIEGYhkgkaFIATQGPLPdtsdDFWRMVWEHKSSTIIMLANEREGGkaMCHKYWPDSGtqmygffeitlhsmkeypdyilrefkivdsrdae
|||||.....|.     .....|||.    ||.....|.. .||..| .| | |  .|..|.|. |                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

gssQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrnSGDKPIVVHCSGGCGRTGTYIATCLLIDRlkteglVDVFQVVRGLRLQRPGMVRSVDQYEF
    .|.......||  |.|.|   .|.. |....     ...|..||||.|.||||| .|  |.. .      |....... .||.|||.|.. .|. |
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

CYKSIL
... .|
qlfall

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 3247-3471 6.7e-35 115.3 In-house 50-269 (301) alignment
Range on Protein: 3247-3471
Range on HMM: 50-269/301.0
NRHKNRYANViPfdktrCKLSTIPG--VDGSD-YINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQM
...|.|| .| |     || ||     |||    | ||.|.   . . ||||||||..||.||| |.  ..  .|.||....|  . .|..| | . .. 
pkdkhryptv.P.....ckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

--YGFFEITLHSMKEY--PDYILREFKIVDSRDaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrnsGDKPIVVHCSGGCGRTGTYIATCLL
   | |.|......     . . |.....|| . . ... |  .||..|. .||| | . | |. | | |      .|||||||| | ||. ..|.|  |
ldigrfkikiknkelilnkkiskrtlevedstg.kfatrtvthyqysewtdrgvPkshaelfdlmelvkk.....sekPivvhcsaGiGrsvafigteyl

IDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQ
  .....  ... . .. || .|   |. . |
areveadptieltealkhlrehrwngvqtnsq

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2952-3114 5.1e-34 112.5 In-house 30-192 (297) alignment
Range on Protein: 2952-3114
Range on HMM: 30-192/297.0
HPDNAIKNRYANISAYDHSRVKLTEdpNVPGSDYINANYIDGYKK--ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDK
 .    |||| .| |.| .||||     ....|||||.|.   ..  .  || .|||.  .. |||....||   ..||...|.| || ||  |||  ..
rnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

RVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHK
     |.. ..   . |    ..    ||    |..| ..   | |||| |||     | ||  .
erlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaq

0044763 (Phosphotyrosine protein) phosphatases II 3258-3478 5.2e-33 109.5 In-house 1-166 (178) alignment
Range on Protein: 3258-3478
Range on HMM: 1-166/178.0
PFDKTRCKLSTIPGVDGSDYINANFIEGYhkgkAFIATQGPlpdtsDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTqmygffeitlhsmkey
|.| || .||...|. .||||||..| ..     ......|      |......|.. ..|..|..| |.|.  |..|||..                  
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

pdyilrefkivdsrdaegssqhvKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGdKPIVVHCSGGCGRTGTYIATCLLIDRlkteGLvDVFQVVRG
                        |.... .|  ||||.   .|.. | .|... ..| .|..|||| | ||.|| .|  |.. .    || ....... 
.......................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaiel

LRLQRPgMVRSVDQYEFCYKS
.| .|| .| . .|....|. 
vrerRp.ivpnpgqlrqLyef

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 3245-3483 7e-33 108.8 In-house 33-270 (285) alignment
Range on Protein: 3245-3483
Range on HMM: 33-270/285.0
SPNRHKNRYANVIPFDKTRCKLSTipgvDGSDYINANFIEGYHKGK-AFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQ-
  |   ||||.|   ..||  |         ||| |...    | . ..|.||||||.|  |||.|... | . ..||.   |||   |  |.|.   . 
eanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-MYGFFEITLHSMKEY--PDYILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWqrNSGDKPIVVHCSGGCGRTGTYIATCLL
  .| .||||   ||      ||  . .... ||     .... |   || .  |. |  .... . |.|   |  .|||.|||| | ||| |..     
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsagvgrtatfvgidya

IDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
  |.  .  ......|| .|  |   |.|  |. | |  ..|..
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf

PTPc_DSPc_SM00012 3380-3481 2.3e-32 106.7 In-house 2-105 (105) alignment
Range on Protein: 3380-3481
Range on HMM: 2-105/105.0
VKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSG-DKPIVVHCSGGCGRTGTYIATCLLIDRLKTE-GLVDVFQVVRGLRLQRPGMVRSVDQYEFCYK
||...| .|| .|||...  .|.. ..|.|....|.  ||.||||| |.|||||..| ..|...|..| . ||.||.|. || ||||||.. .|| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

SILE
 .||
alle

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 3289-3477 9.4e-32 104.8 In-house 3-198 (199) alignment
Range on Protein: 3289-3477
Range on HMM: 3-198/199.0
G-KAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWP--DSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQY
| . .|||| || .|  |||.||||  |  |.|. ...   .|    |||  .|||  || . .| ...   ||| .  . ....  |  |.. . ..|.
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

VSWPSKGVPDSAI--GLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRL--KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYK
 ||  |  |. |.  |..    .| |   .  | |..|||| | | || ..|  . .         .||.|.| . ||  | |.. |...|.| |.
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 3246-3483 1.1e-31 104.6 In-house 36-269 (281) alignment
Range on Protein: 3246-3483
Range on HMM: 36-269/281.0
PNRHKNRYANVIPFDKTRCKLST-IPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMY
 | .||||.|.  .| .| .|   .|  . .||| ||.|      . .| ||||  .|  |||||.|. ....|.||..  |  .  | .|.|       
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahccl

GFFEITLHSMKEYPDYILREFKIVdsRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwqRnSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
 | ....       .  |   ..      || .. . .. .  ||   ||.|.  .| .  ..    | .   | |.||| | ||.|| .|  . .. ..
qfdklsvsyedstvnkslvttrln..lsyegetrlithwlwkewpdwqvpessevmlkilrki....r.arstppvihcsagvgrsgtlmaveialqsih

TE-GLVDVFQVVRGLRLQ-RPGMVRSVDQYEFCYKSILEFL
.   | |. |.|  ||.  |   |....|| . .| .|.| 
shftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 3290-3477 1.3e-31 104.3 In-house 4-197 (198) alignment
Range on Protein: 3290-3477
Range on HMM: 4-197/198.0
KAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWP--DSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQYVS
. .|||| || .|  |||.||||  |  |.|. ...   .|    |||  .|||  || . .| ...   ||| .  . ....  |  |.. . ..|. |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPSKGVPDSAI--GLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRL--KTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYK
|  |  |. |.  |..    .| |   .  | |..|||| | | || ..|  . .         .||.|.| . ||  | |.. |...|.| |.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2951-3207 2.3e-31 103.6 In-house 48-297 (301) alignment
Range on Protein: 2951-3207
Range on HMM: 48-297/301.0
QHPDNaiKNRYANISAYDHSRVKLTEDPN-VPgsdyINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDK
  |..  |.|| ..    .. |.. .| . ||    | ||.|.   . . .||.|||.. .  ||| |.   . |..|||..  ||   ||. | |   .
ylpkd..khryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

RVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSD---ERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFITISCQ
. .  |. .|..... .. .  |   .|. . |..    ||.  | ...|.| |||.  . |  ... |.    |   |.|||||||.||. .||.  . 
ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteyl

IQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLeYLECGETEVSAREVKEQFR
 ....  . ... . .. .| .|   |||. |  ..    . |    | ..  .  .||..
areveadptieltealkhlrehrwngvqtnsqlywmtlGtv.yrlikeygfdmkiyeeqla

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 3246-3483 4.1e-31 102.9 In-house 47-287 (305) alignment
Range on Protein: 3246-3483
Range on HMM: 47-287/305.0
PNRHKNRYANVIPFDKTRCKLstiPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYG
 ...|||| .|  .|. | ||    |    .|| ||..    . | || || || .|  ||| | ...|  .|.|| |  | |   |..|..    ..  
qeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

FFEITLH------SMKE-----YPDYILREFKIVdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwqRNSgDKPIVVHCSGGCGRTGTYI
| |   .      | ..       .  ..| ..|    . .....|... .. || .||| . . .|.. |.     | |   ||||||| | ||||. .
feekgqkisvkfessvtlkfrkdakakvtetvlv.iegpgekarkvthyhwidwpdrgvpaadlailelleka....rps.kgpivvhcsagigrtgsvv

ATCLLIDRLKTEGLV-DVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
    ..|.| .   . |  .... .| ||   ... .|| | .. ||...
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 3246-3479 1.2e-30 101.1 In-house 51-286 (310) alignment
Range on Protein: 3246-3479
Range on HMM: 51-286/310.0
PNRHKNRYANVIPFDKTRCKLsTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSG-TQMY
 . |||||..|.  |..| || .|      ||| ||..   .  ..|| .||||  |  |||||... .. .|..| .  | |.  |  |||  | |. |
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GFFEITLH--SMKEYPDY-----ILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwQRNSGdkPIVVHCSGGCGRTGTYIATC
|   .|    | .|.        .. .   || . |.     |.  ..  || .||||     .  |      |   |  | ||||| | .|... .|  
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrlla...qvrhg..pcvvhcsagkdrlyvvvalk

LLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSI
| ||.|.    ||. .|.  |. .|   ...  || .  .  
lkidkldrglkvdaeevktellksraiciqtelqyliidrvr

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2959-3194 5.6e-30 99.1 In-house 47-280 (312) alignment
Range on Protein: 2959-3194
Range on HMM: 47-280/312.0
NRYANISAYDHSRVKLTEDPNVpgsdYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPP-------PDKRV
||| ||  .|  |  |. | |     || ||..    | . ....|||.  ... ||..     . ....|. . | |  ||  |           |.||
nrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

VVHGQIRIQLQEElSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFITISCQIQQIL
       |..    |    | | . .  | . .|  ...| ..|||| |.|.   | ||..  |.    |.  ||. |||||||||||.. |   |  . 
yteycteieiggk.skdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk....kdkkpviahcsagvgrtgtlaliesmiaalr

DRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGE
  .  .. .    .|  |.  |.. .||..   ..||.| .  
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg

subfamily_CG42327_pd Subfamily CG42327 3223-3402 9.8e-30 98.3 In-house 8-185 (319) alignment
Range on Protein: 3223-3402
Range on HMM: 8-185/319.0
EKEFDNIQETIHREPIVFTGTaspnRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGK-AFIATQGPLPDTSDDFWRMVWEHKSSTIIML
 .||...   | |   | ...    . |.|..||.|. .||  |  |.  | . |..|... ||.. .  .||.| .| |.| ||||.||| .| .|. |
aeefrdlPqliaradevPvts....kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivql

ANEREGGKAMCHKYWPDS----GTQMYGFFEITLHSMKEYPDYILREFKIvDSRDAEgSSQHVKQFQYvSWPSKGVPDSAIGLLD
..  | |  .| .|.| .    .|..|| . .||   .    |..  . .    | |  |...  . |  |.  .|| .   |. 
tdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll.krvdke.esrelthywy.kwleaevPaeeaalia

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 3240-3483 1.4e-29 97.7 In-house 46-289 (305) alignment
Range on Protein: 3240-3483
Range on HMM: 46-289/305.0
FTGTASP--NRHKNRYANVIPFDKTRCKLSTIPgvdGSDYINANFIEGY-HKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYW
|    |.  .  ||||..|   |..  ||.  .    |||| ||..       | ||..|||| .| |.|| || ..|   |.||..  | ||  | .||
fnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqyw

PDSGTQMY----GFFEITL---HSMKEYPDYILREFKIVDSrdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwqRNSgDKPIVVHCSGGCGR
| .  .      |     .   . |.  ..  .  ...  |    . .  |...|.  || .|||   .  |..   .    | |   ||||||| | ||
paaqgeklelksgivvenvsgskpmerdaeiqitllnltys...gdqkmsvrhlqwtewpdrgvppckltslellsai....rgs.kvpivvhcsagigr

TGTYIATCLLIDRLKTEG-LVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
||| .|   .....  .     . ..|. || ||   ...  || | .. .|...
tgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_egg_pd Subfamily egg 2953-3191 1.7e-29 97.4 In-house 38-271 (307) alignment
Range on Protein: 2953-3191
Range on HMM: 38-271/307.0
PDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKgrIKCHLYWPP--PDKR
 .|  | |   .   | |||||         |.| ||...|    | .| .| |.  .  |||||..... . .||||   |    .|. |||    |  
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

VVVHGQIRIQLQEELSLTDYTIRTFSLQHkVSSD-ERTIKQYHFTSWPDFGVPEHPTTLLRFIHkvqrenpKNAGPVVVHCSAGVGRTGTFITISCQIQQ
|.| | .||.  .  | .|   |   |.  | .| |    ..    .   .    |  .|| .        . . ||||..  || ...|...|   . .
vtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqgdvnnssdvysplrvlrklr.......nlskpvvvqdilGvskaatlvaieialls

ILDRKC--LDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
.|        . . |. .| || . |..  .|.|..  .| .. 
llrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3084-3227 1.7e-28 94.2 In-house 87-230 (440) alignment
Range on Protein: 3084-3227
Range on HMM: 87-230/440.0
DERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK-NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFI
. ||.||||. .||| |||.    .|..|. |.  . |   ||..||||||.||||  |.. . ...      .||..|..|||  |  ||||  || |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDALLEYLECGETEVSAREVKEQFRLLNEVfDKEEGKTRLEKEFD
|.|.|| | ||.| .   .. |.   ..   .    |. |..||.
heavlegllcgdtliledditerveqiqwp.nphtdksplqqefe

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 3247-3483 1.7e-28 94.5 In-house 43-271 (288) alignment
Range on Protein: 3247-3483
Range on HMM: 43-271/288.0
NRHKNRYANVIPFDKTRCKLStipgVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGF
|  ..|| |.   | || |||     |   ||.|| .   .  . .| .| ||  | . .|.|. |     |.||..  | ||    .|.|    .   .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

FEITLHSMKEYpDYILREFKIVDSRDAEG--SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwqrNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK
  .     |.. . | .  |.   |  .    .. ||.  .  |. .|||.. .  | . | .     .| .||||||.| | ||||| | . . .. |.
grlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslr

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
 .  . . ...  || .|   ...  || . .. .|| |
lddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_CG42327_pd Subfamily CG42327 2956-3116 3e-28 93.4 In-house 29-191 (319) alignment
Range on Protein: 2956-3116
Range on HMM: 29-191/319.0
AIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDGYKK-ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDK--RVV
  |.|..|.    ..|| | . .. . . |..|.|. ||.. .| |||.| .   |  ||||..|||.. ..| ||.| |.|  .|  |.|. .      
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

VHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFtSWPDFGVPEHPTTLLRFIHKVQ
..|.|.. |..  .   | | |. |..   .  | .  | .  |.. .|| ....|.  . .|.
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

subfamily_egg_pd Subfamily egg 3225-3483 7.3e-28 92.1 In-house 19-270 (307) alignment
Range on Protein: 3225-3483
Range on HMM: 19-270/307.0
EFDNIQETIHREPIVfTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANE
 .  ..|.......  |  .. |..| |   |   | .| ||    |    |.| || ..|      || .| || .| |||||||.. .   |.||.  
rlevleesvdeislt.taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsr

REGgkAMCHKYWPDSGTQMY----GFFEITLHSMKEYPDYILR--EFKIVDSRDAEgssQHVKQFQYvSWPSKGVPDSAIglldvreQVEKWQRNSgDKP
.|     |. ||| . ..      | ..|.   ... .| ..|  ..|.| . | |   .... .|.  .   .   | .       .| .  ||   ||
kes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddee...rflehwqg.dvnnssdvyspl.......rvlrklrnl.skp

IVVHCSGGCGRTGTYIATCLLIDRLKTEGL--VDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
.||..  |. ...| .|  . .  |    .    | . |  |||.|.  | || .| | |. .| |.
vvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff

0048076 (Phosphotyrosine protein) phosphatases II 3064-3189 5.2e-27 89.7 In-house 22-142 (145) alignment
Range on Protein: 3064-3189
Range on HMM: 22-142/145.0
ELSLTDYTIRT-FSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNaGPVVVHCSAGVGRTGTFITISCQIQqildrKCLDIYNFV
   | |. |.| ..| .  .  ||.. ||....|||.|||. . .||.|.. ...  ... |||.||||||||||||.. . . ..     . ..... .
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleeal

QSMRYRRCFMVQTEAQYIFIHDALLEY
. .| .| ..|... |..|.....||.
elvrsqrpgavpnpgqlrflyefelel

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 3249-3489 8.1e-27 88.7 In-house 45-282 (312) alignment
Range on Protein: 3249-3489
Range on HMM: 45-282/312.0
HKNRYANVIPFDKTRCKLSTipgvDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDsgtqMYGFFE
  ||| |.  .|. |  |.     |   || |||.    | . |..||||| .|.  ||...    |..||.|.   | |   | ||  |    . || .
dlnrypniqcwdrgrftlag....denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd....ivgfvd

ITLHSM-KEYP----------DYI-LREFKIVdsRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrnsGDKPIVVHCSGGCGRTGTYIAT
.  | .  ||           | |  | .|.|    | |   .....|. ||| .|.|||    | .   | |       ||.. ||| | ||||| .  
ledhrvyteycteieiggkskdkithrvlkvv..vkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk.....dkkpviahcsagvgrtgtlali

CLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFLGSFDTY
  .|  |.     .| ..   || .|   || . || .. ...|||| |   |
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly

0048179 (Phosphotyrosine protein) phosphatases II 3066-3184 2.1e-25 84.6 In-house 27-139 (144) alignment
Range on Protein: 3066-3184
Range on HMM: 27-139/144.0
SLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNaGPVVVHCSAGVGRTGTFITISCQIqqildRKCLDIYNFVQSM
.|  .|. ... ..   . ||.. ||....|||.|||.... ||.|.. ...  ... |||.||||||||||||....   .     .. |.... .. .
klgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalv

RYRRCFMVQTEAQYIFIHD
| ||...|... |..|...
rsrrpgavpnpgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 3362-3480 3.2e-23 77.4 In-house 36-140 (145) alignment
Range on Protein: 3362-3480
Range on HMM: 36-140/145.0
LrefkivdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSgdKPIVVHCSGGCGRTGTYIATCLLIDrlktEGlVDVFQVVRGLRLQ
|       ... |. .... |..|..||  ||||..  ||.. |..|.....   .|..|||| |.|||||..| .|..     .| |....... .| |
l.......tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsq

RPGMVRSVDQYEFCYKSIL
|||.| ...|..|.|. .|
rpgavpnpgqlrflyefel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2955-3082 4.2e-23 76.6 In-house 47-187 (350) alignment
Range on Protein: 2955-3082
Range on HMM: 47-187/350.0
NAIKNRYANISAYDHSRVKLTEDP--------NVPGSDYINANYIDGY----KKENA--YIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKC
   |||| ||  |.|||||| . .         . ..|||||||.       . .    ||| |.|.|  . ||...| . | . ...||.. | .. ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HLYWPppdkRVVVHG-QIRIQ--LQEELSLTDYTIRTFSLQHKVS
. ||.    .  ... .....   ..  .  | ..... .... |
yrYWq....egsydditvklaskwenimgindsslysadvkkeas

0048179 (Phosphotyrosine protein) phosphatases II 3367-3477 1.7e-22 75.1 In-house 48-139 (144) alignment
Range on Protein: 3367-3477
Range on HMM: 48-139/144.0
IvdsrdaegssqhVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRnsGDKPIVVHCSGGCGRTGTYIATCLLIdrlkTEGlVDVFQVVRGLRLQRPGMV
             . |.....||  ||||..  ||.. | .|....   ..|..||||.|.|||||..| .|..    ..| ........ .| .|||.|
e............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgav

RSVDQYEFCYK
 . .|..|...
pnpgqlrfLle

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2942-3191 1.8e-22 74.2 In-house 38-286 (302) alignment
Range on Protein: 2942-3191
Range on HMM: 38-286/302.0
QHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgsDYINANYIDGYKKENAYIASQGPVP---HSIVDFWRMIWEQKTETVVMLTNLEEKGRi
.  ..   . . .|  ||.  .. ..|. .|||.. |.    .|.||  ..  . ..  | .| |.    .|. .||||....|  .||.|   ||  . 
mkvdlekCkafkknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.

KCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTiRTFSL--QHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKNAGPVVVHCSAGVGR
  . ..|      . .|....  .   .  . .   ...    .  |.   .. |..| |..  ||.. ..| . ..||  .. |   ..|.    |.||
tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGR

TGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
 |.|.|    .... . |   | . |.|.|  |. .|..  ||.... ||| |. 
agafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 3127-3193 5.3e-22 72.0 In-house 2-68 (69) alignment
Range on Protein: 3127-3193
Range on HMM: 2-68/69.0
VVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECG
|||||.| |||||||.|  .. .|   | .||.| || ||  |  ||  | .|||||||| | |  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2995-3183 1.2e-21 71.8 In-house 2-197 (199) alignment
Range on Protein: 2995-3183
Range on HMM: 2-197/199.0
KKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSS--DERTIKQYH
| .  |||.| |. ... |||.|.||  .  .||. . . .      .|||  .  .  .| . .  .   .  |||| .. |  ....    | | .| 
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FTSWPDFGVPEHPtTLLRFIH---KVQR--ENPkNAGPVVVHCSAGVGRTGTFITISCQIQQILDRK--CLDIYNFVQSMRYRRCFMVQTEAQYIFIH
|||| .   |.    .. |.    .| .  |.  .  ||.|||| | | || |...   ..   . |   .|...  . .|  || .. .  .| ||.
ftswkekttpnva.lfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2996-3205 1.2e-21 71.9 In-house 33-237 (255) alignment
Range on Protein: 2996-3205
Range on HMM: 33-237/255.0
KENAYIAsqgpvphSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEelSLTDYTIRTFSLQHKVS--SDERTIKQYHF
. | |.        ..  |...|  .|||.||||....|.|. ||. |.|       .  .. .   .  | .|  .||  .  ...     .|.| |..
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysy

TSWPDFGVPEHPTTLLrFIHKVQRENpKnagPVVVHCSAGVGRTGTFITISCQIQQI---LD---RKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALL
. |..   || .  .| .| || |.  |   .||||||.|.||. .|. .    |..   ||      ||  .... .| .|   ..|  |  |    .|
kGWieknaPelareil.nilkvvrds.k...svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

EYL-ECGETEVSAREVKEQ
...   || |    |... 
dlvfpkgeleakyqeirks

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2997-3183 1.6e-21 71.4 In-house 3-196 (198) alignment
Range on Protein: 2997-3183
Range on HMM: 3-196/198.0
ENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSS--DERTIKQYHFT
.  |||.| |. ... |||.|.||  .  .||. . . .      .|||  .  .  .| . .  .   .  |||| .. |  ....    | | .| ||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDFGVPEHPtTLLRFIH---KVQR--ENPkNAGPVVVHCSAGVGRTGTFITISCQIQQILDRK--CLDIYNFVQSMRYRRCFMVQTEAQYIFIH
|| .   |.    .. |.    .| .  |.  .  ||.|||| | | || |...   ..   . |   .|...  . .|  || .. .  .| ||.
swkekttpnva.lfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 3127-3193 3.3e-21 69.4 In-house 1-67 (69) alignment
Range on Protein: 3127-3193
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECG
|||||.| |||||||.|  .. .|   | .||.| || ||  |  ||  | .|.|||||| | |  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2959-3206 4e-21 70.4 In-house 23-266 (290) alignment
Range on Protein: 2959-3206
Range on HMM: 23-266/290.0
NRYaNISAYDHSRVKLTEDPNVPGSDYINANYIDgYKKENAYIASQGPVPHS-------IVDFWRMIWEQKTETVVMLTNLEEKGRI----KCHLYWPPP
.|. ...   ..|| | .  .   .||| ||..  . .  . |..| |  .        | .|| |. . | . |||| . ||| .      |  | |  
qRl.evpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

DKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKvSSDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQrenpKNAGPVVVHCSAGVGRTGTFITISCQI
    .  . . .. ..     |  .|.  ...     | |.. . . .| .  |.|.. |||  |.||.    ..  ||.|||  |. |  .. .|    
vgeelkfkgltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgy

QQIL-DRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLeylecgeteVSAREVKEQF
| |   .. . . . ....| .|  ..... .. |.  ...         . | ||..||
Qkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.........llaievldqf

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2938-3189 6.7e-21 69.2 In-house 30-278 (303) alignment
Range on Protein: 2938-3189
Range on HMM: 30-278/303.0
TVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEdpnvpgSDYINANYIDGYKKENAyIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGR
 |     |.    |  .|  |||....   |||.|||..      | || |.|..   . .| | .| |..|.  |||.|| |||   |..|    |  .
kvvsylppsvsknqfvknmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydk

IKCHLYWPPPDKRV-VVHGQIRIQLQEELSLTD-YTIRTFSLQHkvSSDERTIKQYHFTSWPDFGVPEH-PTTLLRFIHKVQRENPK--NAGPVVVHCSA
.  .  .|  .  .   .  ||.    .. |.| ....  |.     .    .. .|. .||   .| .    ... | ..|    |  .. | |    .
lggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsn..gdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls

GVGRTGTFITISC-QIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEY
|.||.|||  .   ..    .. .||. . .. .|  |   ||  .|. ...  | |.
gcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 3006-3182 1.8e-20 67.6 In-house 99-280 (302) alignment
Range on Protein: 3006-3182
Range on HMM: 99-280/302.0
PVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRI---QLQEELS-LTD------YTIRTFSLqHKVSSDERTIKQYHFTS
|   ..  .| .| . ..  || |... |..  ||  |.    . ..  |.  .   .....|. .||      ||.      .| .  ..|..  .|..
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveikne.kkkkkvkktvdilafsa

WPDFGVPEHPTTLLRFIHKVqrENPKNAgpVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFI
||| | |... | |  ..    |  |..  |.||||||||||||...|   ||  . .|  |. . |. .|  |   ||.| | |..
wpdhGapkeaytaldilkfc..esykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 3249-3355 3.6e-20 67.0 In-house 49-166 (350) alignment
Range on Protein: 3249-3355
Range on HMM: 49-166/350.0
HKNRYANVIPFDKTRCKLS--------TIPGVDGSDYINANFIEGY----HKGKAF--IATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHK
 |||| |..|....| ||             . ..||||||...      .    |  ||||.||| | |||.... . |   |..|... | .   |..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDSGTQMygfFEITLHSMK
||.. . .    . . | |..
YWqegsydd...itvklaskw

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3376-3488 3.9e-20 66.6 In-house 87-199 (440) alignment
Range on Protein: 3376-3488
Range on HMM: 87-199/440.0
SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFC
 |. .||..| .|| ||||  |  .| . ..|.. | ..|. |..|||| |.||||  ||   ..   |    .|.| ..  .| .|| ||.. .|| | 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YKSILEFLGSFDT
....|| | . ||
heavlegllcgdt

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 3219-3482 3.6e-19 63.3 In-house 25-284 (302) alignment
Range on Protein: 3219-3482
Range on HMM: 25-284/302.0
KTRLEKEFDNIQETihREPIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIPgvdgSDYINANFIEGYHKGKAFIATQGPLPDTS---DDFWRMVWEHKS
.....|||..|...  . ..    .   | .||.  .|   |... ||.. |     .|.||  .|  . ..  | .| |  |..   ..|||||...| 
taevkkefkkidtm..kvdlekCkafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

STIIMLANEREGGKaMCHKYWP-DSGT-QMYGFFEITLHSMKEYPDYIlREF--KIVDSRDAEGSSQHVKQFQYvsWPSKGVPDSAIGLLDVREQVeKWQ
 .. .|. | |  |   ....|  ||. . || . .     ..  .    ..   ..    ..     |. ...  |..| ||..   |    ..|   .
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakv.fak

RNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
  ..|...|.    |.|| |. ..  . ...|...  . . ..|. .| ||| .| |..|| . | ..| .
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 3302-3483 4.3e-19 63.6 In-house 40-221 (255) alignment
Range on Protein: 3302-3483
Range on HMM: 40-221/255.0
TSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLL
| | |....   |.....||..  | |.  |..|.|    .   . .... . |   | .||  .|.         . || ..|  |. |  |. |  .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DVReqveKWQRNSgdKPIVVHCSGGCGRTGTYIATCLLID----RLKTE--GLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
 .     |  |.|  |..||||| | ||. ... . |.       |.|   . .|  .... || .|.. .    |  |.   .|...
nil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 3215-3393 9.4e-19 62.0 In-house 62-235 (244) alignment
Range on Protein: 3215-3393
Range on HMM: 62-235/244.0
KEEGKTRLEKEF-DNIQETIHREPIVFTGTASPN-RHKNRYANVIPFDKTRCKLSTipGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWE
|.||   .. .. .  |. |. .| |.  . .||  .||| .  .|||  |  ||   |  |  |||| |.    .   .| || || ||| |||.|. |
kkegsdyinanyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmle

HKSSTIIMLANEREGgkamcHKYWPDSGTQMYGF--FEITLHSMKEYPDYILREFKIvdSRDAEGSSQHVKQFQYVSWPSKGV
 .   ...|    |       .|||||    .      .||    |. .    ...|    | . | | .  ||   ||| | 
rhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnlei..esdmneshqaltmfqisnwpsdgt

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 3205-3482 6.4e-18 59.4 In-house 8-278 (303) alignment
Range on Protein: 3205-3482
Range on HMM: 8-278/303.0
QFRLLNEVFDKEEGKTRLeKEFDNIQETIhrEPIVFTGTASPNRHKNRYANVIPFDKTRCKLStipgvDgSDYINANFIEGYHKGKAfIATQGPLPDTSD
...|| . . .|. .    .||...   .   | |       | .|||...|| .|... |||     | | || |...|   . || | || ||. |. 
kwkllakrtldedaniav.nefekvvsyl..ppsvsknqfvknmdknrfvdvicldhskvkls.....d.ssyihasyleldsskka.iltqlplshtaa

DFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSgtQMYGFFEITLHSMKEYPDYILR---EFKIVDSRDAEGsSQHVKQFQYVSWPSKGVPDS-AIGL
|||.|. | |   ...|  . |  |   .  .|    | .  ||     . |.    |     .|..   . .     ..  .| .|| . .|   .  .
dfwqmiieqkvkcvlllltdseydklggdsvfprn..qdflkfeersirvgefkrvelgdgwvlkvlsvsngdy.ksflhvhhykawphnsipsdgspkf

LDVREQVEKWQRN-SGDKPIVVHCSGGCGRTGTYIATC----LLIDRLKTEGLVDVFQVVRGLRLQrpgMVRSVDQYEFCYKSILEF
.    |..   |. |  .| |     ||||.||.         | .   .  || ... ||  ||.    |. . |. . |  . | 
vkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlh...avqnlsqfsvvytllaeh

subfamily_hpo-7_pd Subfamily hpo-7 2998-3189 8.7e-18 59.2 In-house 38-226 (263) alignment
Range on Protein: 2998-3189
Range on HMM: 38-226/263.0
NAYIAsqgpVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSltDYTIRTFSLQHKVS--SDERTIKQYHFTS
| |.     .   |  |...|  .|||.||||.. .|.|. ||  |.|       .  .. .   .  |  |  ..|  |   ..     .|.|.| .. 
nlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykg

WPDFGVPEHPTTLLRfIHKVQRENpKnagPVVVHCSAGVGRTGTFITISCQIQQI---LD---RKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEY
|..   || .   |. | || |.  |   ..|||||.|.||.  |  .    |..   ||      ||  .... .| .|   ..|  |  |    .|..
Wiekndpelareiln.ilkvarns.k...slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf





fn3 Fibronectin type III domain 2033-2122 1.4e-16 53.6 Pfam-A 1-85 (85) alignment
Range on Protein: 2033-2122
Range on HMM: 1-85/85.0
SPPQDFTVDNITSNTFTLSWSPPIerDINGVIDLYTIRYFITEQLGvdpVDPSINVRNVSAtSVTLTDLGNYTEYNISVSAVTVG-VGPSS
|.|....|...||...|||||||   | .| |. |...|  ... .   .. ...| . .  |||||.|  .|||...| ||. .  ||.|
saPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge...ewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS

subfamily_hpo-7_pd Subfamily hpo-7 3301-3483 1.5e-16 55.1 In-house 45-227 (263) alignment
Range on Protein: 3301-3483
Range on HMM: 45-227/263.0
DTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQMYGFFEITLHSMKEYPDYILREFKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGL
.| | |....   |.....||..  | |.  | .|.|    .   . .... . |   | .|.  ...   .     . ||...|. |. |  |  |.  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LDVreqvEKWQRNSgdKPIVVHCSGGCGRTGTYIATCLLID----RLKTE--GLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
| .     |  |||  |..||||| | ||.  .  . |.       |.|   . .|  .... || .|.. .    |  |    .|.|.
lni....lkvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 3295-3472 4.9e-16 53.0 In-house 96-277 (302) alignment
Range on Protein: 3295-3472
Range on HMM: 96-277/302.0
TQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMCHKYWPDSGTQM--YGFFEITLHSMK----EYP---DYILREFKIVDSRDAEGSSQHVKQFQY
   |  .| . .| .. ... . .. |..  |...  | .|. |   .   .| . ..  |.|    |.    .. |   .| ...  .   . |. ...
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

VSWPSKGVPDSAIGLLDVREQVEKWQRNsgdkpIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQY
 .|| .| |. |   ||.    | ...|     ..|||| | ||||| .|    |.  ...   |. ..|  .|  | | |.. .| 
sawpdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2913-3005 6.3e-16 52.3 In-house 6-95 (95) alignment
Range on Protein: 2913-3005
Range on HMM: 6-95/95.0
SVGDFPAHVANMHANDDYLFSVEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNvpgSDYINANYIDGYKKENAYIASQG
 |  | .|| .||.| |  |  |. ..      .  .     |  |||. ||  || .|| ||   .   |||||| ..||| . |.|||.||
hvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg

fn3 Fibronectin type III domain 1835-1918 1.2e-15 50.5 Pfam-A 3-85 (85) alignment
Range on Protein: 1835-1918
Range on HMM: 3-85/85.0
PVNLSTSDVTSRNLTLSWDEPHHNNAPILGYDIAYtEPDFLGRRNIELTVNGSIEMLFIDGLHPGVSYNFSVNAFNEEGDSGFS
| ||| |.|||..|||||..|.....|| ||.. | ...  |.   | || .. . . . || || .|.|.| | |..| ...|
PenlsvsevtstsltlsWsppkdgggpitgYevey.rekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 3259-3480 1.5e-15 52.1 In-house 30-256 (290) alignment
Range on Protein: 3259-3480
Range on HMM: 30-256/290.0
FDKTRCKLSTIPGVDGSDYINANFIEgYHKGKAFIATQGPLPDT-------SDDFWRMVWEHKSSTIIMLANEREGGKA----MCHKYWPDSGTQMYGFF
. .||  |        .||| ||..  . .| ..|.|| |. ..         .|| |. . |.  ..|| .  |  .      | || |.|  .   | 
veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfk

EIT--LHSMKEYPDYILREFKIVDSrdaEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEkwqrnSGDKPIVVHCSGGCGRTGTYIATCLLIDRLK-
 .|    |. .  | . ||  .      ..    |.  ....| .  |... . ||.. ..|.       . |..|||  |  |  .  |  |    .  
gltvkCkskekeddvetRelvvkfd...deeeftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiae

TEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSIL
|.| | . .|.  || ||  .. |  .. |    |.
tsgsvkledvlkalrkqralaitsalelafvdagiv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2956-3045 3.7e-15 50.1 In-house 49-154 (349) alignment
Range on Protein: 2956-3045
Range on HMM: 49-154/349.0
AIKNRYANISAYDHSRVKLTEDPNVPG--------------SDYINANYID--GYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIK
  |||| .|  |.|||||| . .. .                |||||||.    .. |. ||| | |.| .. ||...|  .. . |. |.. .|..  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHLYWP
|. || 
cdiywq

subfamily_CG42327_pd Subfamily CG42327 3414-3482 4.3e-15 50.2 In-house 245-314 (319) alignment
Range on Protein: 3414-3482
Range on HMM: 245-314/319.0
SGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTE-GLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
.   |.||||| | ||||. ||. . | .|..    ||. |.|  .| .|   |....|||| || . |.
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_eak_pd Subfamily eak 3222-3394 6.7e-15 49.3 In-house 31-195 (332) alignment
Range on Protein: 3222-3394
Range on HMM: 31-195/332.0
LEKEFDNIQETIHREpivfTGTASPNRHKNrYANVIPFDKTRCKLSTiPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIML
. ...|. |.    .     ..   . ..|   ...|.|.   .|..    .   ||||  .|  . |. .| |  .  |    ||.|| | || .|..|
ivadlddyqrllsis....etarleavnrn.vvkivpydrylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivql

ANEREGGKAMCHKYWPDSG--TQMYGFFEITLHSMKEYPDYILREFKIVDSRDaegsSQHVKQFQYVSWPSKGVP
... | .     ||.|| .     .|.....  .  .   .  | ...    .    . .|. ...  |    .|
ledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGne....thrvlhykvfGwtettlp

fn3 Fibronectin type III domain 2373-2466 6.9e-15 48.2 Pfam-A 3-83 (85) alignment
Range on Protein: 2373-2466
Range on HMM: 3-83/85.0
PQVLTVVNQsNSTSLLITWYPPECYNGILDGYQIFYRAEQSDGalgnptspvtiPVLATTASNTTQlTQTITGLTPNTEYEVIICATNGAGCGQ
|. |.| .. .|||| ..| ||.  .| ..||.. || ... .           .    |...||. . |.|||.|.||||. . | ||||.|.
Penlsvsev.tstsltlsWsppkdgggpitgYeveyrekggge...........ewkeftvprttt.svtltgLkpgteYefrVqavngagegp

subfamily_CG42327_pd Subfamily CG42327 3121-3189 2.3e-14 47.8 In-house 245-314 (319) alignment
Range on Protein: 3121-3189
Range on HMM: 245-314/319.0
KNAGPVVVHCSAGVGRTGTFITISCQIQQILDR-KCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEY
.. ||.||||| ||||||. |.   .|... .  . .|| . |.|.|  |.  |.|  || ||.  | ||
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 3419-3482 4.5e-14 46.6 In-house 1-64 (69) alignment
Range on Protein: 3419-3482
Range on HMM: 1-64/69.0
IVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEF
.||||| | |||||.||  . . |.|.| |||.|  |. .|  || ||    .| | . .. | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 3420-3483 5.2e-14 46.3 In-house 1-64 (69) alignment
Range on Protein: 3420-3483
Range on HMM: 1-64/69.0
VVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILEFL
||||| | |||||.||  . . |.|.| |||.|  |. .|  || ||   ..| | . .. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 3086-3190 2e-13 44.8 In-house 215-344 (350) alignment
Range on Protein: 3086-3190
Range on HMM: 215-344/350.0
RTIKQYHFTSWPDFGVPEHPTTLLRFIH--------KVQR--ENPKNAGPVVVHCSAGVGRTGTFITISCQIQQILD------------R--KCLD-IYN
  . | ..  |.| ..  .|  .|. .          . .   . ... |..||||||||||||..|.   ......            .  |  | |  
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

FVQSMRYRRCFMVQTEAQYIFIHDALLEYL
 |. .| .|  |||.  |.|||..||| | 
ivnelrkqrismvqnldqfifiYeallfyf

fn3 Fibronectin type III domain 1934-2019 3.4e-13 42.7 Pfam-A 3-85 (85) alignment
Range on Protein: 1934-2019
Range on HMM: 3-85/85.0
PQILSSSTINSTAVNVTWMPVPpaQRNGIITGYTIFITTDVEFVNDTTQDIPSAATlQYTFTRLQEYVNYTYTILARTAIGDGPIS
|. || | ..|| ....| | .  ...| ||||..   .. .   ......|. .| ..|.| |... .|.... |... | || |
PenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS

Ig_2 Immunoglobulin domain 762-846 3.9e-13 41.2 Pfam-A 5-80 (80) alignment
Range on Protein: 762-846
Range on HMM: 5-80/80.0
NPEEQYAEVGDDVTLNCSADSFPAPNYQWEMMNrtsgyfEPLDDETS--YVltlESISYEEYGMYRCVATADGIeeNATSTPALVTV
... .... |..|||.|.|...|.|..||.  .      |.|.  ..  ..    ..|.|. | |.|.|. ..    ..|..  |||
sapptvvtegenvtLtCqapgnptpkvqwykdg......eelsqsqnalfi...pnvsaedsGtYtCrasnseg..skqsnsvevtv

Ig_3 Immunoglobulin domain 1555-1626 4.5e-13 41.2 Pfam-A 1-73 (75) alignment
Range on Protein: 1555-1626
Range on HMM: 1-73/75.0
RPVITIQPQEVLTVANVsVSLNCLADSFP-APYYQWR-YTPANGTSQYVPGANESTLVFPSINYEEFGSYVCIA
.|||...|... |..   |.|.| |...| .| ..|   || .  ... .. .||||...| ..|  |.| |.|
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCva

fn3 Fibronectin type III domain 2136-2226 5.7e-13 42.0 Pfam-A 2-83 (85) alignment
Range on Protein: 2136-2226
Range on HMM: 2-83/85.0
PPQMVTVVTVSTTSIKVNWAAPPlnMTFGIITRYEILYGEYNATTgqlingtdPIRQVTVTSNTFMYVFNGLQEAREYGFQVRAVTVG-PGP
.|. ..|  |..||. ..| .|.     | ||.||. | | . .         . ...||...|  ....||.. .|| |.|.||. .  ||
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge........ewkeftvprtttsvtltgLkpgteYefrVqavngagegp

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 3272-3393 8.2e-13 42.8 In-house 10-126 (130) alignment
Range on Protein: 3272-3393
Range on HMM: 10-126/130.0
VDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGgkamcHKYWPDSGTQMYGFFEITLHSM-KEYPDYIlREFKIVDS
..| .||||.|.    . . .. || || ||| |||.|. |     ...|    |       .|||||    .   .|.. .  ..  ..| .  ..  .
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkni.kasnleie

RDAEGSSQHVKQFQYVSWPSKGV
.|   | | .  ||   ||| | 
sdlneshqaltmfqisnwpsdgt

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2955-3039 1.2e-12 42.0 In-house 34-117 (332) alignment
Range on Protein: 2955-3039
Range on HMM: 34-117/332.0
NAIKNRYANISAYDHSRVKLTedPNVPGSDYINANYIDGYKKENAYIASQGPVP-HSIVDFWRMIWEQKTETVVMLTNLEEKGRIK
|   ||   . ..|||||.|.  |.    |. ||...||| |..||| .| |.  |.   ||||. |.|   .... ...|| . |
nmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2992-3080 1.3e-12 41.8 In-house 230-314 (440) alignment
Range on Protein: 2992-3080
Range on HMM: 230-314/440.0
DGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKgriKCHLYWPPpDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHK
.|| | ||.||.| |.  ...||||.. . .  |..|| .|..|    | .|||  . | |  | . .  .    .    .||. |..|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv.ntrsvtfgpftvghkgsenmnrvkvrtlelkyk

subfamily_eak_pd Subfamily eak 2945-3103 2e-12 41.2 In-house 42-196 (332) alignment
Range on Protein: 2945-3103
Range on HMM: 42-196/332.0
PTKDATQHPDNAIKNrYANISAYDHSRVKLTEDPNVPgSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRIKCHLYW
 ..  |.  ..  .|   .|  ||.  |.||     .   ||||  ..  .  . || .  .    .  ||.|. |||. ..|.| .  |..  |   |.
lsisetarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLqhKVSSDERTIKQYHFTSWPDFGVPE
|   . .. .|.. .. .| .    .  | . |  ..  .   .. |..  | .. .| 
pdktreelkfGildverkefvkrniletrllel..skGnethrvlhykvfGwtettlpk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 3379-3481 3e-12 40.9 In-house 216-342 (350) alignment
Range on Protein: 3379-3481
Range on HMM: 216-342/350.0
HVKQFQYVSWPSK---GVPDSAIGLLDVREQ------VEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLID-------------RLK--TEgLVD-VFQ
 | |.|.  |.       | | .  |.|...       |..  |.  .||.|||| |.|||||...   |.              .|.  .. . | ...
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDlisi

VVRGLRLQRPGMVRSVDQYEFCYKSILE
.|  || ||  ||...||. |.|...| 
ivnelrkqrismvqnldqfifiYeallf

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2938-3061 6.8e-12 39.5 In-house 80-195 (244) alignment
Range on Protein: 2938-3061
Range on HMM: 80-195/244.0
TVEPQHHPTKDATqHPDNAIKNRYANISAYDHSRVKLTEDpnVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGR
 . |.    |||   |.|. ||| .    .| .|| |..     |  |||| ..    .   || .| |.  . .|||.|. |.. . .|.|  .||.  
iirpdpsvmkdaf.npnnswknregaglpfdfnrvplskg..smgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede

ikchlYWPPPDKRVVVHGQIRIQL
     |||  .       .| . |
.....ywpdseplewyeeditvtl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 3249-3339 8.2e-12 39.1 In-house 50-156 (349) alignment
Range on Protein: 3249-3339
Range on HMM: 50-156/349.0
HKNRYANVIPFDKTRCKLSTI--------------PGVDGSDYINANFIE--GYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREGGKAMC
 |||| ...|.. .| ||                  .    ||||||...   .   | .|||| ||| | |||....   .   .. | .. | .   |
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HKYWPDS
..|| . 
diywqel

I-set Immunoglobulin I-set domain 255-352 1.1e-11 36.3 Pfam-A 3-90 (90) alignment
Range on Protein: 255-352
Range on HMM: 3-90/90.0
VITPSNPLIVSRNENASFNCTAQGGPNNTIVWIKGenNSSLSFrpppinvlRTLELFTVIESGPILTFTSVNGSNGGIYTCVVLNEAGIESDAVELRV
. ...... || .|.....||..| |. .. | |.  .|.|.              .|| |.   ||...|. |. |.|||.. |.|| ..  .|| |
ftqklkdvevseGesvelectveGepepsvsWakd..gselks........sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

Ig_2 Immunoglobulin domain 1158-1246 1.3e-11 36.4 Pfam-A 3-80 (80) alignment
Range on Protein: 1158-1246
Range on HMM: 3-80/80.0
VITEDPREafTNVSDTVTLTCRADSFPAPNYQWEMMNrtngyfEPLTGQTS--YVltlESISYEEYGMYRCVATADGIeeNATSTPALVTV
|... | .   . ...|||||.|...|.|..||.  .      |.|. ...  ..    ..|.|. | |.|.|. ..    ..|..  |||
vlsapptv..vtegenvtLtCqapgnptpkvqwykdg......eelsqsqnalfi...pnvsaedsGtYtCrasnseg..skqsnsvevtv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3283-3339 1.3e-11 38.5 In-house 229-282 (440) alignment
Range on Protein: 3283-3339
Range on HMM: 229-282/440.0
IEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIMLANEREggkAMCHKYWPDS
.||| | .|||||| ||  |  ||||.| ... |||||| .  .     |  |||  
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvn

Ig_3 Immunoglobulin domain 1729-1813 2e-11 36.0 Pfam-A 2-75 (75) alignment
Range on Protein: 1729-1813
Range on HMM: 2-75/75.0
PVITVNPVSINVSIEVenITLNCTARGFP-VPTITWAhndslitsteDEIFIYTNPTSYLRTVLSTIVINSAMANNTGDYVCIASS
|||.|.| ....| .   .||.|.|.|.|  |||.|           .|   . ... ..... || .| |. ....| | |.||.
Pvisvspsptvtsggn..vtLtCsaeggpppptisWy..........ietppelqgsegssssestLtissvtsedsGtYtCvasN

I-set Immunoglobulin I-set domain 1729-1825 3e-11 35.0 Pfam-A 1-88 (90) alignment
Range on Protein: 1729-1825
Range on HMM: 1-88/90.0
PVITVNPVSINVSIEvENITLNCTARGFPVPTITWAHNDSLITSteDEIFIYTNPTsylrtVLSTIVINSAMANNTGDYVCIASSPfYNSVNSTVAL
|..|  . ...||.. |...|.||..| | |...||...| ..|  .. . .|.         .|..|... ....|.| | |.   . ...... |
pkftqklkdvevseG.esvelectveGepepsvsWakdgselks..sqrvkvtvee.....aeytLtIsnvevsDeGkYtckatns.agkaeakaeL

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2934-2993 3.4e-11 37.1 In-house 26-85 (440) alignment
Range on Protein: 2934-2993
Range on HMM: 26-85/440.0
VEYPTVEPQHHPTKDATQHPDNAIKNRYANISAYDHSRVKLTEDPNVPGSDYINANYIDG
 |.  .        | .  |.| .|||| || ||||||| | |   || |||||| ||.|
dewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying

Ig_3 Immunoglobulin domain 1157-1229 4.7e-11 34.7 Pfam-A 2-74 (75) alignment
Range on Protein: 1157-1229
Range on HMM: 2-74/75.0
PVITEDPREAFTNVSDtVTLTCRADSFP-APNYQWEmmNRTN--GYFEPLTGQTSYVLTLESISYEEYGMYRCVAT
|||.  |..  |..   |||||.|...| .|...|   . |.        ..... .||..| ..| .| |.|||.
Pvisvspsptvtsggn.vtLtCsaeggpppptisWy..ietppelqgsegssssestLtissvtsedsGtYtCvas

0038934 (Phosphotyrosine protein) phosphatases II 3384-3478 5.7e-11 37.9 In-house 81-172 (194) alignment
Range on Protein: 3384-3478
Range on HMM: 81-172/194.0
QYV--SWPSKGVPDSAIGLLDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLlIDRLKTeglvDVFQVVRGLRLQRPGMVRSVDQYEFCYKS
.|.   .|..|.. |   ||.  . |... ... .. ..||| .| ||||| .|  | | ||.     .. . .. .|  |||.....|..|  .| 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.iyrlgm....saeeAialfrekRpgaipnqdyleallkr

I-set Immunoglobulin I-set domain 659-754 6.4e-11 33.9 Pfam-A 7-89 (90) alignment
Range on Protein: 659-754
Range on HMM: 7-89/90.0
PDTQIVSRNSSPTFTCEASGGPNTTLAWIRGnEDNIEStqtpididsffdFLDVIVSETAPSLELSLENVNGTDGGNYTCIAVNEAGYDNGTVSLL
.. . || ..| ...|...| |. .  | .. . ...|              .| |...  . .| ..||.  | |.||| | |.|| .. ...| 
lkdvevseGesvelectveGepepsvsWakd.gselks............sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLk

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 3223-3297 6.8e-11 36.2 In-house 22-95 (95) alignment
Range on Protein: 3223-3297
Range on HMM: 22-95/95.0
EKEFDNIQETIHRE--PIVFTGTASPNRHKNRYANVIPFDKTRCKLSTIpgvDGSDYINANFIEGYHKGKAFIATQG
..||||   .|         .|..  |  |||. |..|.| ||  |.|      |||||| |..|| . ...||.||
dqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaqg

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 3115-3189 7e-11 36.5 In-house 221-294 (297) alignment
Range on Protein: 3115-3189
Range on HMM: 221-294/297.0
VQRENPKNAgPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEY
.. | |.|| ...|||||||||.|  .     ....  ..  |.  ... .| .|  .|||  |. ...|| |. 
lraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk

Ig_3 Immunoglobulin domain 559-633 8.2e-11 34.0 Pfam-A 1-75 (75) alignment
Range on Protein: 559-633
Range on HMM: 1-75/75.0
APIITLHPQDRLVTQGEyFTLSCLADAFP-SPTYQWERMNRTSGNFEEISGEISSDLRFNNVDFDEFGMYRCVASS
.|.|...|.   .. |.  ||.| |. .| .||..| . .  . .  |.|....|.| . .|...  | |.||||.
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvasN

Ig_2 Immunoglobulin domain 1729-1821 8.6e-11 33.7 Pfam-A 2-73 (80) alignment
Range on Protein: 1729-1821
Range on HMM: 2-73/80.0
PVITVNPvsiNVSIEVENITLNCTARGFPVPTITWAHNDSLITSTEDEifiytnptsylrtvlstIVINSAMANNTGDYVCIASSPFYnSVNS
||....|    |  | ||.||.|.|.|.| |...| ............                 . |... |.. | | | || . . | .|
pvlsapp...tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna.................lfipnvsaedsGtYtCrasnseg.skqs

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 3120-3191 1.1e-10 35.3 In-house 262-345 (349) alignment
Range on Protein: 3120-3191
Range on HMM: 262-345/349.0
PKNAGPVVVHCSAGVGRTGTFITISCQIQ--QILD----------RKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLE
 ..  ...|||||| ||||...|.   ..  . |            .   |.  | ..|  |  |||  ||.|.|..|||.|. 
tdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa

Ig_3 Immunoglobulin domain 757-829 1.3e-10 33.4 Pfam-A 2-74 (75) alignment
Range on Protein: 757-829
Range on HMM: 2-74/75.0
PEILTNPEEQYAEVGDdVTLNCSADSFP-APNYQWEmmNRTSGYFEPLDDETSYVLTLE--SISYEEYGMYRCVAT
|.| ..|..   ..|  |||.|||...| .|...|   . |...... ..  |.  ||   | ..| .| |.|||.
Pvisvspsptvtsggn.vtLtCsaeggpppptisWy..ietppelqgsegssssestLtissvtsedsGtYtCvas

fn3 Fibronectin type III domain 2244-2358 1.5e-10 34.2 Pfam-A 3-85 (85) alignment
Range on Protein: 2244-2358
Range on HMM: 3-85/85.0
PQNPRAPPQndiGPTSVTLSWDPIPvDEANGDLEYSVNISADDQVSntgnrrkrqmpptltnslqqcitaagtsNMLNYMLPGNQTSLTLTNIAPYTVYS
|.|... ..   ..||.||||.| . |    .  |.|  . ... .                               .. .|...||.|||.. |.| |.
Penlsvsev...tstsltlsWsppk.dgggpitgYeveyrekggge............................ewkeftvprtttsvtltgLkpgteYe

FDVTGVTSAGRGPTS
| |. |. || ||.|
frVqavngagegpeS

Ig_3 Immunoglobulin domain 136-223 3.1e-10 32.1 Pfam-A 12-73 (75) alignment
Range on Protein: 136-223
Range on HMM: 12-73/75.0
IL---AtigdanLTLTCNATGFP-APNITWVrlpsndlnesmildlydsdapetiDDDSMISFSTDSDTDSSSILTFDSIEYNDFGHYACIA
.           .||||.|.|.| .|.|.|                         .. .... ....  .|.|.||. |  ..| | | |.|
vtsggn......vtLtCsaeggpppptisWy........................ietppelqgsegssssestLtissvtsedsGtYtCva

Ig_3 Immunoglobulin domain 353-427 6.2e-10 31.2 Pfam-A 1-74 (75) alignment
Range on Protein: 353-427
Range on HMM: 1-74/75.0
RPEILTNPSNIYTQDGEgdVSFECLADSFP-SPQYRWERFNETLNEFYPISNESERFLMFNEVEYEDNGRYRCVAT
.|.| ..||.. | .|.  |.. | |...| .|...| . ..  ..   .|..||  | . .| .||.| |.|||.
kPvisvspsptvtsggn..vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvas

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 3247-3324 9.7e-10 32.4 In-house 34-110 (332) alignment
Range on Protein: 3247-3324
Range on HMM: 34-110/332.0
NRHKNRYANVIPFDKTRCKLSTIPGVDgsDYINANFIEGYHKGKAFIATQGPLPDTSD-DFWRMVWEHKSSTIIMLANE
|   ||   .  ||..| .|.   | |  |. ||....|| |  |.| .| |. | ..  ||||| |.| | |... . 
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdi

Ig_2 Immunoglobulin domain 1350-1426 1.1e-09 30.2 Pfam-A 2-69 (80) alignment
Range on Protein: 1350-1426
Range on HMM: 2-69/80.0
PVITLNPtdQYAHPGDTVTISCMADSFPPPTYQWQVLNTDTNMYQDIngetmtnFTIEEIDYDQFGMYRCAVTTPTI
||.. .|  .... |..||. | |...|.|..||.  .. ..  |..       . | .. ... | |.| .. .  
pvlsapp..tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnseg

Ig_2 Immunoglobulin domain 1653-1727 1.6e-09 29.7 Pfam-A 5-80 (80) alignment
Range on Protein: 1653-1727
Range on HMM: 5-80/80.0
TPQVNNSFEEQSVTLACGARGGPNNGFQWNytRTGAIVGMDPD--YTLNTSVETAGYYQCIVSN-RAGSDDNTATVNV
...  . .| ..||| | |.| |.  .||   . |...   ..  .. |.|.|..| |.| .|| . .   |. .|.|
sapptvvtegenvtLtCqapgnptpkvqwy..kdgeelsqsqnalfipnvsaedsGtYtCrasnsegskqsnsvevtv

Ig_2 Immunoglobulin domain 369-430 2.1e-09 29.3 Pfam-A 14-68 (80) alignment
Range on Protein: 369-430
Range on HMM: 14-68/80.0
EGDVSFECLADSFPSPQYRWERFNETLNefypisnESER--FLmfNEVEYEDNGRYRCVATAPT
  .| . | |...| |.. |.. .|.|.       .|..  |.  ..|..||.|.|.|.|. . 
genvtLtCqapgnptpkvqwykdgeels.......qsqnalfi..pnvsaedsGtYtCrasnse

Ig_2 Immunoglobulin domain 659-745 2.1e-09 29.3 Pfam-A 7-69 (80) alignment
Range on Protein: 659-745
Range on HMM: 7-69/80.0
PDtQIVSRNSSPTFTCEASGGPNTTLAWIRGNeDNIESTQTPididsffdfldvivsetapsleLSLENVNGTDGGNYTCIAVNEAG
|. . |. ... |.||.|.| |.... | ... . ....|                        | . ||. .|.|.||| | |. |
pp.tvvtegenvtLtCqapgnptpkvqwykdg.eelsqsqna......................lfipnvsaedsGtYtCrasnseg

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 3379-3483 2.5e-09 30.9 In-house 219-344 (349) alignment
Range on Protein: 3379-3483
Range on HMM: 219-344/349.0
HVKQFQYVSWPSKGV---PDSAIGLLDVREQV------EKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLID----------RLKTEGL-VD-VFQVVRG
 . |.|.  |.  ..   | | .  |.|....      ...  ..   ...|||| ||||||...   ||..          ..| . |  | .. .|  
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRLQRPGMVRSVDQYEFCYKSILEFL
|| ||  ||. . |. ..|...|...
lrkqrismvqnlaqfiaiyealLkyf

0038934 (Phosphotyrosine protein) phosphatases II 3090-3142 3.1e-09 32.2 In-house 81-134 (194) alignment
Range on Protein: 3090-3142
Range on HMM: 81-134/194.0
QYHFTSWPDFGVPEHPTTLLRFIHKVQRENPKN-AGPVVVHCSAGVGRTGTFIT
.|.   .||.|..    .||||.. |.. . ..  | |.||| ||.|||||.. 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva

Ig_2 Immunoglobulin domain 559-636 3.4e-09 28.6 Pfam-A 1-69 (80) alignment
Range on Protein: 559-636
Range on HMM: 1-69/80.0
APIITLHPQDrlVTQGEYFTLSCLADAFPSPTYQWERMNRTSGNFEEIsgeissdLRFNNVDFDEFGMYRCVASSEGI
.|...  |.   ||.|| .|| | |...| |..||.. . .  . ...       |  .||  .. | |.|.|| .. 
kpvlsapptv..vtegenvtLtCqapgnptpkvqwykdgeelsqsqna.......lfipnvsaedsGtYtCrasnseg

I-set Immunoglobulin I-set domain 354-429 3.9e-09 28.2 Pfam-A 1-78 (90) alignment
Range on Protein: 354-429
Range on HMM: 1-78/90.0
PEILTNPSNIYTQDGEgDVSFECLADSFPSPQYRWERFNETLNE--FYPISNES-ERFLMFNEVEYEDNGRYRCVATAP
|.. . .... .. || .|..|| .   | |. .| . .. |..   . ...|. |  |....|| .|.|.|.|.||  
pkftqklkdvevseGe.svelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatns

Ig_2 Immunoglobulin domain 950-1026 3.9e-09 28.4 Pfam-A 2-69 (80) alignment
Range on Protein: 950-1026
Range on HMM: 2-69/80.0
PVITLNPtdQYAHPGDTVTISCMADSYPPPTYQWQVLNTDTNMYQDIngemmtSYTiEDIDYDQFGMYRCAVTTPTI
||.. .|  .... |..||. | |.. |.|..||.  .. ..  |..      ...   . ... | |.| .. .  
pvlsapp..tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna......lfi.pnvsaedsGtYtCrasnseg

Ig_2 Immunoglobulin domain 255-352 5.1e-09 28.0 Pfam-A 3-80 (80) alignment
Range on Protein: 255-352
Range on HMM: 3-80/80.0
VITPSNpLIVSRNENASFNCTAQGGPNNTIVWIKGENNSSlsfrpP---PinvlrtlelftviesgpiL-TfTSVNGSNGGIYTCVVLN-EAGIESDAVE
|.....   |. .||  ..|.|.| |. .. | |...  |     .                      | .  .|. ...|.|||.. | | .. |. ||
vlsapp.tvvtegenvtLtCqapgnptpkvqwykdgeels.....qsqna..................lfi.pnvsaedsGtYtCrasnsegskqsnsve

LRV
..|
vtv

Ig_3 Immunoglobulin domain 1349-1420 5.4e-09 28.2 Pfam-A 1-72 (75) alignment
Range on Protein: 1349-1420
Range on HMM: 1-72/75.0
PPVITLNPTDQYAHPGDtVTISCMADSFP-PPTYQWQVLNTDTNMYQDINGETMTNFTIEEIDYDQFGMYRCA
.|||...|       |  ||..| |...| |||..|.  ... .  ......... .||.. .... | |.| 
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCv

Ig_2 Immunoglobulin domain 1047-1153 5.9e-09 27.8 Pfam-A 4-78 (80) alignment
Range on Protein: 1047-1153
Range on HMM: 4-78/80.0
IDPDFVIAENGSNVTFNCLSRGGPNNRFIWLRPsaldslisnnpsvssllnsespikvDDIVNQLSNItlsnepTFTlYSINAtEDGGNYACYVVN-PAG
... .. .. |.|||..| ..| |. ...| .                          .....|  |.       |.  ...| ||.|.| |.. | . .
lsapptvvtegenvtLtCqapgnptpkvqwykd.........................geelsqsqna......lfi.pnvsa.edsGtYtCrasnsegs

VESNTTTL
  ||....
kqsnsvev

fn3 Fibronectin type III domain 2593-2662 1.4e-08 28.0 Pfam-A 2-77 (85) alignment
Range on Protein: 2593-2662
Range on HMM: 2-77/85.0
SVYNLTASSQTSSSILARWDVPLLPNGNITRYDI-YSNSSGTP----F--GSTTSlFYILNGLTTGRTYNVTVRPVT
.. ||..|..||.|.  .|. |  ..|.||.|.. |....|.     |   .||.  ..|.||. |..|...|. |.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavn

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 3249-3321 1.6e-08 28.4 In-house 39-116 (347) alignment
Range on Protein: 3249-3321
Range on HMM: 39-116/347.0
HKNRYANVIPFDKTRCKLST-----IPGVDGSDYINANFIEGYHKGKAFIATQGPLPDTSDDFWRMVWEHKSSTIIML
 |||  .|   |.||  ||       .  |   ||||  |      | .| || |||||  |||.||   | . .. .
sknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

Ig_3 Immunoglobulin domain 666-742 2.7e-08 25.9 Pfam-A 15-75 (75) alignment
Range on Protein: 666-742
Range on HMM: 15-75/75.0
RNSsPTFTCEASGGP-NTTLAWIrgnedniestqtpidiDSFFDFLDVIVSETAPSLELSLENVNGTDGGNYTCIAVN
  .  |.||.| ||| ..|. |                 ..  . |.   .    .  |....|.  | |.|||.| |
ggn.vtLtCsaeggpppptisWy................ietppelqgsegssssestLtissvtsedsGtYtCvasN

I-set Immunoglobulin I-set domain 757-835 2.7e-08 25.5 Pfam-A 1-81 (90) alignment
Range on Protein: 757-835
Range on HMM: 1-81/90.0
PEILTNPEEQYAEVGDDVTLNCSADSFPAPNYQWEMMNR---TSGYFEPLDDETSYVLTLESISYEEYGMYRCVATADgIEE
|.. . .... ...|..|.|.|..   | |. .|   ..   .|  ..   .| .| ||..... .. | |.|.||   ...
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatns.agk

Ig_3 Immunoglobulin domain 950-1020 3.3e-08 25.6 Pfam-A 2-72 (75) alignment
Range on Protein: 950-1020
Range on HMM: 2-72/75.0
PVITLNPTDQYAHPGDtVTISCMADSYP-PPTYQWQVLNTDTNMYQDINGEMMTSYTIEDIDYDQFGMYRCA
|||...|       |  ||..| |...| |||..|.  ... .  ...... ....||.. .... | |.| 
Pvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCv

I-set Immunoglobulin I-set domain 1350-1424 3.9e-08 25.0 Pfam-A 1-78 (90) alignment
Range on Protein: 1350-1424
Range on HMM: 1-78/90.0
PVITLNPTDQYAHPGDTVTISCMADSFPPPTYQWQVLNTDTNMYQDINGETMT---NFTIEEIDYDQFGMYRCAVTTP
|..|  ..|. .. |..|...| .   |.|. .|.  .....  |... .       .||.... .. | |.| .|  
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatns

subfamily_PTPDC1_pd Subfamily PTPDC1 3086-3184 4.2e-08 27.8 In-house 81-170 (182) alignment
Range on Protein: 3086-3184
Range on HMM: 81-170/182.0
RTIKQYHFtSWPDFGVPEhPTTLLRFIhKVQRENPKNAgPVVVHCSAGVGRTGTFITisCQIqqiLDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHD
. |  | | .|.|.||.   ...|  . ||     ..   | ||| || ||||  |.  | .   .  | |.  . .. .| .|   .||  |  ....
qgiyvynf.gwkDygvas.leriLdiv.kvvafalqeg.kvavhChaGlGrtGvlia..cyl...vyakrltaekaiklvrskrpksiqtreqvelvke

PTEN_1 3383-3462 4.8e-08 28.0 In-house 95-171 (196) alignment
Range on Protein: 3383-3462
Range on HMM: 95-171/196.0
FQ--YVSWPSKGVPDSAIgLLDVREQVEKW-QRNSGDKPIVVHCSGGCGRTGTyIATCLLIDRLKteglVDVFQVVRGLRLQR
..   ....  |.|. .  |.|. .... | ....  . ..||| .| ||.|| .. ..|. . |     .. . .. .| .|
veylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGt.vvaayLmykgk....ltadeAlelvrekR

I-set Immunoglobulin I-set domain 1256-1348 5.3e-08 24.6 Pfam-A 7-90 (90) alignment
Range on Protein: 1256-1348
Range on HMM: 7-90/90.0
PMYSTVSINDTANFTCRAQGGPGNMFRWIKGnfnGPTLTAplnvsqfFNSLSIFRSGYELSFIVS-GGAADGGYYTCIVVNEAGYATDNVMLFV
.   .||........|...| |   ..| |.   |  |.         .....  .. | ....|   ..| | ||| . |.|| |. .. | |
lkdvevseGesvelectveGepepsvsWakd...gselks.......sqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

Ig_2 Immunoglobulin domain 1556-1644 7.8e-08 24.3 Pfam-A 2-80 (80) alignment
Range on Protein: 1556-1644
Range on HMM: 2-80/80.0
PVITIQPQEvLtVANVSVSLNCLADSFPAPYYQWRYTPaNGTSqyvPGANEstLVFPSINYEEFGSYVCIAAADGIqeTATSDTAIVTV
||.. .|.. .  .. .| |.| |...|.| .||.    . .|   .. |.  |  |....|. |.| | |  ..    ..|..  |||
pvlsapptv.v.tegenvtLtCqapgnptpkvqwykdg.eels...qsqna..lfipnvsaedsGtYtCrasnseg..skqsnsvevtv

I-set Immunoglobulin I-set domain 138-226 8.9e-08 23.8 Pfam-A 12-78 (90) alignment
Range on Protein: 138-226
Range on HMM: 12-78/90.0
ATIGDaNLTLTCNATGFPAPNITWVRLpSNDLNEsmildlydsdapetiddDSMISFSTDSdtdSSSILTFDSIEYNDFGHYACIAMQS
...|. ...|.|...| | |...|..   ..|..                 .. .... ..   ... ||....| .| | | | |  |
vseGe.svelectveGepepsvsWakd.gselks.................sqrvkvtvee...aeytLtIsnvevsDeGkYtckatns

Ig_3 Immunoglobulin domain 255-339 1.2e-07 23.9 Pfam-A 4-75 (75) alignment
Range on Protein: 255-339
Range on HMM: 4-75/75.0
VITPSNPLIVSRNEnASFNCTAQGGP-NNTIVWIkgennsslsfrppPINVLRTLELFTVIESGPILTFTSVNGSNGGIYTCVVLN
......| ..|  .  ...|.|.||| . || |              . .           .|. .||..||. .. | ||||. |
isvspsptvtsggn.vtLtCsaeggpppptisWy.............ietppelqgsegssssestLtissvtsedsGtYtCvasN

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2954-3029 2e-07 24.9 In-house 36-116 (347) alignment
Range on Protein: 2954-3029
Range on HMM: 36-116/347.0
DNAIKNRYANISAYDHSRVKLTED-----PNVPGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVML
 .  |||  .    | .|| |. .     .  .   |||| .|   . .. || .| |.|... |||.|.   |   || .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 3011-3210 2e-07 23.9 In-house 131-329 (346) alignment
Range on Protein: 3011-3210
Range on HMM: 131-329/346.0
IVDFWRMIWEQKTETVVMLTNlEEKGRIKCHLYWPPPDKRVVVHGQIRIQLQEELSLTDYTIRTFSLQHKVSSDERTIKQYHFTSWPDFGVPEHPTTLLR
. ||| ||.... . | ..   ..| .      .   .      |.. |. .      |    |  .  .  ||    . .| . |  .  | .   ...
vedfwymiyqeqihlvylmvp.ddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiik

FIHKVQRENP-KNAGpVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGETEVSAREVKEQFRLL
.||.   |.  .||| | |    | ||. .||     |.|. .    .|.. ..... .|   |.. |||  |.  ...|.       .|   |.  |..
mihqflsekqvqnag.vcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggkkapvnkdinrfi

N
.
d

I-set Immunoglobulin I-set domain 853-948 2.1e-07 22.6 Pfam-A 4-90 (90) alignment
Range on Protein: 853-948
Range on HMM: 4-90/90.0
DATPMNRTVSINDTANFTCRAQGGPGNMFRWVKGiftGPTFNApldvdeflD-----DLDNisLSYflSFTVSG-GAADGGYYTCIVVNEAGYDTDNVTL
. .. . .||........|...| |   ..|.|.   |   .         .     . ..   .|  ..|.|   ..| | ||| . |.|| .. ...|
tqklkdvevseGesvelectveGepepsvsWakd...gselks........sqrvkvtvee..aey..tLtIsnvevsDeGkYtckatnsagkaeakaeL

YV
 |
kV

I-set Immunoglobulin I-set domain 950-1024 2.7e-07 22.3 Pfam-A 1-78 (90) alignment
Range on Protein: 950-1024
Range on HMM: 1-78/90.0
PVITLNPTDQYAHPGDTVTISCMADSYPPPTYQWQVLNTDTNMYQDINGEMMT---SYTIEDIDYDQFGMYRCAVTTP
|..|  ..|. .. |..|...| .   |.|. .|.  .....  |... ..     . ||.... .. | |.| .|  
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatns

I-set Immunoglobulin I-set domain 1454-1552 2.9e-07 22.2 Pfam-A 12-88 (90) alignment
Range on Protein: 1454-1552
Range on HMM: 12-88/90.0
ADNGSDITFTCSANGGPNNTFLWVRSDEFENLislssvlqnlpfqntisvqdivDELSTITLE-TGTTFSIYNINAtEDGGEYLCIVLNEAGVDSNNTLL
.  |......|...| |. .. |.. ..  .                       ..  ..| |   .|. |.|... .| |.| | . |.|| .. .. |
vseGesvelectveGepepsvsWakdgselks......................sqrvkvtveeaeytLtIsnvev.sDeGkYtckatnsagkaeakaeL





0048567 (Phosphotyrosine protein) phosphatases II 3091-3142 2.9e-07 25.0 In-house 40-96 (157) alignment
Range on Protein: 3091-3142
Range on HMM: 40-96/157.0
YHFTSWPDFGvPEHPTTLLRFIHKVQREN---PKNAGPVVVHCSAGV---GRTGTFIT
.... . ||| | . ..| |||.|. .      .. ....|||.||    |||.|.| 
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLig

subfamily_eak_pd Subfamily eak 3111-3194 4.3e-07 23.6 In-house 226-309 (332) alignment
Range on Protein: 3111-3194
Range on HMM: 226-309/332.0
FIHKVQRENPKNAgPvVVHCSAGVGRTGTFITISCQIQQILDRK--CLDIYNFVQSMRYRRCFMVQTEAQYIFIHDALLEYLECGE
...| .   | .| | .. .. |  |.|.|. |   |. | ..|     . ...  .. .|   | .. |. ||....|.||   .
tlkkyihtppsfa.p.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn

Ig_2 Immunoglobulin domain 143-230 5.1e-07 21.6 Pfam-A 15-69 (80) alignment
Range on Protein: 143-230
Range on HMM: 15-69/80.0
ANLTLTCNATGFPAPNITWVRlPSNDLNESmildlydsdapetidddsmisfsT-DsdtdsssiL-TfDSIEYNDFGHYACIAmqSNDSL
 |.|||| |.|.|.|...| .  .. |..|                       .          | .  .....| |.| | |  ||...
envtLtCqapgnptpkvqwyk.dgeelsqs.......................qna........lfi.pnvsaedsGtYtCra..snseg

PTPc_motif_SM00404 3106-3179 5.2e-07 24.6 In-house 67-130 (140) alignment
Range on Protein: 3106-3179
Range on HMM: 67-130/140.0
TTLLRFIHKVqrenPKNAGPVVVHCSAGVGRTGTFITISCqiqqiLDRKCLDIYNFVQSMRYRRcFMVQTEAQY
  .|.||...     |. | |.||| ||| |..|.|.  .     .... |.. . .. ...||  ...  ...
dkvldfiena....ekkggkvlVHCqaGvSRSatliiaYl.....mryrqlslaeayefvkerR.piispnlnf

PTEN_1 3086-3141 6.5e-07 24.3 In-house 93-148 (196) alignment
Range on Protein: 3086-3141
Range on HMM: 93-148/196.0
RTIKQYHFtSWPDFGVPE---HPTTLLRFIHKVQRENPknAGPVVVHCSAGVGRTGTFI
. ....|| ...|.|.|    .   . .||. ... ..   . |.||| ||.||.|| .
sgveylhf.pieDhgapslselfdicksfiewllsdpn..gnvVlVHCkaGlgRsGtvv

ig Immunoglobulin domain 668-739 7.1e-07 20.5 Pfam-A 2-63 (64) alignment
Range on Protein: 668-739
Range on HMM: 2-63/64.0
SSPTFTCEA-SGGPNTTLAWIRGNEDNIESTQTPIDID-----SffdfldvivsetapslELSLENVNGTDGGNYTCI
|| |.||.. ||.|.|.  |....  ..||..|  . .     .                 | . ||   |.|.||| 
ssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe................vLtinnvtkedsGtYtCv

I-set Immunoglobulin I-set domain 1045-1155 8.1e-07 20.7 Pfam-A 3-90 (90) alignment
Range on Protein: 1045-1155
Range on HMM: 3-90/90.0
VTIDPDFVIAENGSNVTFNCLSRGGPNNRFIWLRPsalDSLISNnpsvssllnsespikvddivNQLSN----ItlsNEPTFTLYSINAtEDGGNYACYV
.|. .. | .. |..|...|  .| |. .. |..    .| ...                    .|  .        .| |.|...... .| |.| | .
ftqklkdvevseGesvelectveGepepsvsWakd...gselks....................sqrvkvtvee...aeytLtIsnvev.sDeGkYtcka

VNPAGVESNTTTLYV
 | || .. ...| |
tnsagkaeakaeLkV

Ig_3 Immunoglobulin domain 1440-1541 1e-06 20.9 Pfam-A 7-75 (75) alignment
Range on Protein: 1440-1541
Range on HMM: 7-75/75.0
SPNSSVSIDPDlhiadngsdITFTCSANGGP-NNTFLWVrsdefenlislssvlqNLPFQNTISVQDIVDELSTITLETGTtfsiyninaTEDGGEYLCI
||...|. ..          .|.|||| ||| . |. |                 . . ..  .... ... || |... |          || | | |.
spsptvtsggn.........vtLtCsaeggpppptisWy................ietppelqgsegssssestLtissvt.........sedsGtYtCv

VLN
. |
asN

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 2955-3036 1.2e-06 21.5 In-house 27-81 (169) alignment
Range on Protein: 2955-3036
Range on HMM: 27-81/169.0
NAIKNRYANISAYDHSRVKLTEDPNVPGSDYINAnyidgykkenayiasqgpvphsivdfwRMIWEQKTETVVMLTNLEEKG
|  ||| |   |  | ||||    .  |||||||                           |||||  .  .|.| . ..| 
netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn

I-set Immunoglobulin I-set domain 1157-1235 1.3e-06 20.1 Pfam-A 1-81 (90) alignment
Range on Protein: 1157-1235
Range on HMM: 1-81/90.0
PVITEDPREAFTNVSDTVTLTCRADSFPAPNYQWEMMNRT---NGYFEPLTGQTSYVLTLESISYEEYGMYRCVATADgIEE
|..|. .... ... ..|.|.|..   | |. .|   ..    .  ..    . .| ||..... .. | |.|.||   ...
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatns.agk

subfamily_ptpA1_pd Subfamily ptpA1 3449-3481 1.3e-06 22.5 In-house 364-396 (418) alignment
Range on Protein: 3449-3481
Range on HMM: 364-396/418.0
VDVFQVVRGLRLQRPGMVRSVDQYEFCYKSILE
...| .|  || ||||||. ..|| ||||.||.
fnlfsivlklreqrpgmvqqleqylfcyktild

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 2955-3036 1.5e-06 21.1 In-house 26-80 (169) alignment
Range on Protein: 2955-3036
Range on HMM: 26-80/169.0
NAIKNRYANISAYDHSRVKLTEDPNVPGSDYINAnyidgykkenayiasqgpvphsivdfwRMIWEQKTETVVMLTNLEEKG
|  ||| |   |  | ||||    .  |||||||                           |||||  .  .|.| . ..| 
netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn

Ig_3 Immunoglobulin domain 1037-1142 1.8e-06 20.1 Pfam-A 4-75 (75) alignment
Range on Protein: 1037-1142
Range on HMM: 4-75/75.0
ITVSSNSSVTIDPDfviaengsnVTFNCLSRGGP-NNRFIWLrpsaldslisnnpsvssllnsespiKVDDIVNQLSNITLSNEPTFTLYSINaTEDGGN
|.||....|| ..          ||..| ..||| . .. |.                         .  . ..| |... |.| |.|. | .  || |.
isvspsptvtsggn.........vtLtCsaeggpppptisWy.........................ietppelqgsegssssestLtissvt.sedsGt

YACYVVN
| |.. |
YtCvasN

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2968-3048 1.9e-06 22.2 In-house 6-73 (130) alignment
Range on Protein: 2968-3048
Range on HMM: 6-73/130.0
DHSRVKltedpnvpGSDYINANYIDGYKKENAYIASQGPVPHSIVDFWRMIWEQKTETVVMLTNLEEKGRikchlYWPPPD
. ||..        | .||||...    . . |. .| |.  . .|||.|. |.  . .|.|  .||.       |||  .
evsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdse

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 3083-3190 2e-06 21.6 In-house 224-338 (347) alignment
Range on Protein: 3083-3190
Range on HMM: 224-338/347.0
SDERTIKQYHFTSWPDFGVPEHPTTLLRFIHKVQRENPK-------NAGPVVVHCSAGVGRTGTFITISCQIQQILDRKCLDIYNFVQSMRYRRCFMVQT
|.    | |  |.||    |.    .| ..    .|          .  |||| |  |. |. | .  |  |.|.|| |  |  .. . || .|. .   
seatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftm

EAQYIFIHDALLEYL
   | .   | | ||
sifytyairaalfyl

subfamily_CDC14_pd Subfamily CDC14 3418-3476 2.2e-06 21.7 In-house 265-317 (328) alignment
Range on Protein: 3418-3476
Range on HMM: 265-317/328.0
PIVVHCSGGCGRTGTYIAtCLLIDRLKteglVDVFQVVRGLRLQRPGMVRSVdQYEFCY
 |.|||  | ||||| || | |. . .    .   ...  ||. |||.| .  | .|..
aiavhCkaGLGrtGtLia.cylmkhyr....ftaaeaiawlricrPGsvigp.qqkfle

Ig_2 Immunoglobulin domain 1256-1342 2.5e-06 19.4 Pfam-A 8-74 (80) alignment
Range on Protein: 1256-1342
Range on HMM: 8-74/80.0
PmySTVSINDTANFTCRAQGGPGNMFRWIKGNfngptltAPLNVSQ-FfnslsifrsgyelSFIVSGGAADGGYYTCIVVNE-AGYATD
|  ..|. ... ..||.|.| |   . | |..       ..|. ||               .|| .  | |.| ||| . |.  .  ..
p..tvvtegenvtLtCqapgnptpkvqwykdg.......eelsqsqna.............lfipnvsaedsGtYtCrasnsegskqsn

Ig_2 Immunoglobulin domain 452-548 2.6e-06 19.3 Pfam-A 4-69 (80) alignment
Range on Protein: 452-548
Range on HMM: 4-69/80.0
IDPAFTIATNGSTVTFTCSARGGPNNTFVWTRSnatgsmanetelmslaamipidvdgfldlaGpLIIENGTE-LTLEYINATmDGSNYSCVVINEAG
... .| .| |..||.||.|.| |. .. |..                               |  ....... | .  ..|. |. .|.|.. |. |
lsapptvvtegenvtLtCqapgnptpkvqwykd..............................g.eelsqsqnalfipnvsae.dsGtYtCrasnseg

subfamily_PTEN_pd Subfamily PTEN 3401-3454 2.6e-06 22.5 In-house 99-154 (184) alignment
Range on Protein: 3401-3454
Range on HMM: 99-154/184.0
LDVREQVEKWQRNSGDKPIVVHCSGGCGRTGTYIATCLLIDRLKTEG--LVDVFQV
 .. |..|||  .. .. .||||  | ||||. |.. ||  .| ..    ...|. 
eeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfae

Ig_2 Immunoglobulin domain 1453-1551 3.1e-06 19.1 Pfam-A 10-77 (80) alignment
Range on Protein: 1453-1551
Range on HMM: 10-77/80.0
IADNGSDITFTCSANGGPNNTFLWVRSdefenlislssvlqnlpfqntisvqD--------IvdelstitletgttFSIYNINAtEDGGEYLCIVLN-EA
 .. |...|.||.|.| |. .. | .                          .        .              . | |..| ||.| | | . | | 
vvtegenvtLtCqapgnptpkvqwykd.........................geelsqsqna..............lfipnvsa.edsGtYtCrasnseg

GVDSNNTL
.  || . 
skqsnsve

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 3239-3325 3.4e-06 20.1 In-house 19-78 (169) alignment
Range on Protein: 3239-3325
Range on HMM: 19-78/169.0
VFTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINAnfiegyhkgkafiatqgplpdtsddfwRMVWEHKSSTIIMLANER
 |    . |  ||| |  .   .|| ||  .    |||||||                           ||.||  .| |..| .  
nfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtd

I-set Immunoglobulin I-set domain 562-636 4e-06 18.5 Pfam-A 3-80 (90) alignment
Range on Protein: 562-636
Range on HMM: 3-80/90.0
ITLHPQDRLVTQGEYFTLSCLADAFPSPTYQWERMNRTSGNFEEISGEIS---SDLRFNNVDFDEFGMYRCVASSEGI
.| ...|  |..||  .|.| .   | |. .| . ..   . .... . .   . |...||. .. | |.|.|. .  
ftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsag

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 3376-3483 4.2e-06 19.6 In-house 203-309 (346) alignment
Range on Protein: 3376-3483
Range on HMM: 203-309/346.0
SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQV--EKWQRNSGdkpIVVHCSGGCGRTGTYIATCLLIDRLKTEGLVDVFQVVRGLRLQRPGMVRSVDQYE
 |  ..  ..  |     |  .. .. .  |   ||  .| |   . |    ||||. ..| .   |..|      ....... .. |||| | |  || 
dsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnag...vcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqya

FCYKSILEFL
  |  .....
siyaivfdyi

Ig_2 Immunoglobulin domain 859-946 4.3e-06 18.7 Pfam-A 9-78 (80) alignment
Range on Protein: 859-946
Range on HMM: 9-78/80.0
RTVSINDTANFTCRAQGGPGNMFRWVKGiftgptfnapldvDEFLDDLDNIslsyflSFT--VSggAADGGYYTCIVVN-EAGYDTDNVTL
 .|. ... ..||.|.| |   . | |.             .|.|.   |.      .|.  ||  | |.| ||| . | | .  .. |..
tvvtegenvtLtCqapgnptpkvqwykd.............geelsqsqna......lfipnvs..aedsGtYtCrasnsegskqsnsvev

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3246-3285 4.4e-06 20.3 In-house 46-85 (440) alignment
Range on Protein: 3246-3285
Range on HMM: 46-85/440.0
PNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINANFIEG
 |. |||| |.. .|..|  |  . ||  |||||| .|.|
nnkvknryrnilaydhsrvmleevkgvpdsdyinasying

ig Immunoglobulin domain 1172-1228 4.5e-06 17.9 Pfam-A 2-64 (64) alignment
Range on Protein: 1172-1228
Range on HMM: 2-64/64.0
DTVTLTCRA-DSFPAPNYQWEMMNRTNGYFEPLTG-QTSY----VLTLESISYEEYGMYRCVA
..|||||.. .  | ....|   . ..  ...  . ....    |||. . ..|  | |.||.
ssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCvv

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 3240-3325 4.6e-06 19.6 In-house 19-77 (169) alignment
Range on Protein: 3240-3325
Range on HMM: 19-77/169.0
FTGTASPNRHKNRYANVIPFDKTRCKLSTIPGVDGSDYINAnfiegyhkgkafiatqgplpdtsddfwRMVWEHKSSTIIMLANER
|    . |  ||| |  .   .|| ||  .    |||||||                           ||.||  .| |..| .  
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtd

Ig_3 Immunoglobulin domain 455-543 5.3e-06 18.6 Pfam-A 17-73 (75) alignment
Range on Protein: 455-543
Range on HMM: 17-73/75.0
AftiatngstVTFTCSARGGP-NNTFVWTrsnatgsmanetelmslaamipIDVDGFLDLAGPlIIENGTELTLEYINATMDGSnYSCVV
          ||.||||.||| . |. |.                      |. .. |.  .    .... ||..  ..  .|. |.||.
n.........vtLtCsaeggpppptisWy......................ietppelqgseg.ssssestLtissvtsedsGt.YtCva

I-set Immunoglobulin I-set domain 458-558 6.9e-06 17.8 Pfam-A 11-90 (90) alignment
Range on Protein: 458-558
Range on HMM: 11-90/90.0
IATNGSTVTFTCSARGGPNNTFVWTRSnatGSMANEtelmslAAMIPIDVDGfldlagpliieNGTELTLEYINATmDGSNYSCVVINEAGFVAVETTLY
 .. |..|...|...| |. .. |..    ||  ..         . ..|..           . ..||.. ...  |  .|.|.. |.|| .  ...| 
evseGesvelectveGepepsvsWakd...gselks......sqrvkvtvee...........aeytLtIsnvevs.DeGkYtckatnsagkaeakaeLk

V
|
V

Reticulon Reticulon 2838-2876 7.9e-06 12.0 Pfam-A 125-163 (169) alignment
Range on Protein: 2838-2876
Range on HMM: 125-163/169.0
LGFFMTLIILLIIGAIVAVVLFFVYRKYKSGIYSLVRKG
|| .. |. ||.|| |.|......| ||.  | .||.. 
lgslfslltLlyigvilaftvPllYekyqeeIdalvela

V-set Immunoglobulin V-set domain 142-233 9.1e-06 16.5 Pfam-A 16-108 (114) alignment
Range on Protein: 142-233
Range on HMM: 16-108/114.0
DANLTLTCNATgfP---APNITWVRLPSNDLNESMIldlydSDAPETIDDDSMISFSTDSDT-----DSSSILTFDSIEYNDFGHYACIAMQSNDSLMGE
....||.|  .  .     .|.|.. ...  .| .|      . .|| ..  . ||| .        .|.  ||. ... .| | | | ...||   .|.
GgsvtLpCfys..ssensqsiyWykqktgskpelii.....ryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsdsnedvfga