Gene PTPRD-77 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP136_AA protein Get Run
AqueP136_AA_0-186 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1-183 3.1e-78 258.8 In-house 86-265 (564) alignment
Range on Protein: 1-183
Range on HMM: 86-265/564.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIvdSRDAEGSSQHVKQFQ
|| ||||.|||||||..|..||||||||..||||||| . .|.||  ||||||..||. || ...||..  |. ||..|..|.  ..  . .|. |.||.
gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl..kkkkssesreVrqFh

YVSWPSKGVPDSAIGLLDVREQVEKWQrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
..|||..|||.|| .|||....|....  .. .||||||| | |||||.|..  .....|.|..||..|.|. || ||. || 
FtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVq

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-183 1e-74 246.5 In-house 84-264 (318) alignment
Range on Protein: 1-183
Range on HMM: 84-264/318.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDsrDAEGSSQHVKQFQ
|| ..||.||.|.|||.| .|||||||| .|..||||..|.||||| .|.|||..|.. ||   ..|..  |. ||.|||.|.    . | .|..|.|..
GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyh

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
| ||| .|||.|. .|||.  ||.|.|..|| .|||||||.| ||||..||.  |....|||.||||||.|. || ||. ||.
ytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvq

0050432 (Phosphotyrosine protein) phosphatases II 2-185 2.6e-70 232.5 In-house 102-285 (308) alignment
Range on Protein: 2-185
Range on HMM: 102-285/308.0
Y--CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS---GTQIYGFFEITLHSIREYPDYILRELKIVDSRDAegSSQHV
|   ....|||||||||.|..||||||||.....|||| .. |.|.  |..|||..   |...|| | .|| |. ...||..|.|......|    | .|
yssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtv

KQFQYVSWPSKGVPDSAIGLLDVREQVEKWQrdsGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
..|.| .||  |||.|.  |||  |.|.|..   ...||||||| |.|||||.||. ||..||..|| ||||..|. || |||||| ..
thfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-184 8.3e-70 230.4 In-house 95-275 (298) alignment
Range on Protein: 2-184
Range on HMM: 95-275/298.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAegSSQHVKQFQY
| .|.||||||.||. |. ||||||.|....||||| | .| .|  .||||||.|.. || ....|.|  |. |.| |.||. ... .  ....|.|...
ykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhf

VSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
.|||.||||  |  .||....|...|...|.||..|.|| | ||.||.||.  .....|.|  |||||||. || .|||.|..
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqt

0051299 (Phosphotyrosine protein) phosphatases II 1-185 9.6e-70 230.6 In-house 87-272 (288) alignment
Range on Protein: 1-185
Range on HMM: 87-272/288.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDS--RDAEGSSQHVKQ
|| . ..|||||||||.|..||||||||.....|||| .. |.|.  |..|||..|...|| . .|| |. ...||..|.|....    | .| |..|..
gynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvth

FQYVSWPSKGVPDSAIGLLDVREQVEKWQRdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|.| .||  |||||.  |||  ..| |... ||..|.||||| |.|||||.||. ||..||..|| |||...|. || |||||| ..
fhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

0046845 (Phosphotyrosine protein) phosphatases II 3-185 5.7e-67 221.4 In-house 74-260 (284) alignment
Range on Protein: 3-185
Range on HMM: 74-260/284.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG-TQIYGFFEITLHSIREYPDYILRELKIVDSrDAEGSSQHVKQFQY
 ..|.|||||||||.|..||||||||.....|||| .. |.|. .|..|||..| ...|| | .|| |. ...||..|.|....  . .| | .|..|.|
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhy

VSWPSKGVPDSAIGLLDVREQVEKWQRD-SGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEG---LVDVFQVVRGLRLQRPGMVRSV
 |||  |||.|.  ||.  ..|...... .|..|||||||.|.|||||.||. ||..||..||    |||...|. || |||||| ..
tswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-183 6.5e-67 220.8 In-house 86-267 (319) alignment
Range on Protein: 1-183
Range on HMM: 86-267/319.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIvDSRDAEGSSQHVKQFQ
|| .|..|||||.|| .|..||||||||..||..|||..  |..|  ..||||.   . || . .|| . .|  ||| |.||. . . .|  . .||.||
gyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfq

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
| .|| ..||..| .|||. ....| .. . ..||||||| | |||||.|..   ....| ||..|||..|. ||.||. ||.
yteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvq

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-184 9.6e-67 220.3 In-house 84-268 (305) alignment
Range on Protein: 1-184
Range on HMM: 84-268/305.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQ--IYGFFEITLHSIREYPDYILRELKIVDSRDaEGSSQHVKQ
|| ..|..|..||||..| .||||...|.| ||||||.. .| ||  |..|||.| |.   .| |...|.| ....||| |.|||   .. .  |. | |
gykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlq

FQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
.|  .|| .|||..|  ||.. ..|.| |. . ..|..|||| | ||||..||. . ...||.|. ||||.|.. || .|..|| .
yqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqt

0040438 (Phosphotyrosine protein) phosphatases II 2-186 2.8e-66 219.3 In-house 82-263 (317) alignment
Range on Protein: 2-186
Range on HMM: 82-263/317.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSrdAEGSSQHVKQFQY
. ....|||||||||.|..||||||||.....|||| .. |.|. .|..|||. .|. || | .|| |. |.....||.|...|.   .. | .|..|.|
pnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhy

VSWPSKGVPDSAIGLLDVREQVEKWQRdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSVM
 .||  |||.|   |||  |.|..... ....|..||||.|.|||||.||. |...||. || |||...|. || ||||.| . .
tgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpe

0047943 (Phosphotyrosine protein) phosphatases II 2-185 9.2e-66 217.4 In-house 73-258 (273) alignment
Range on Protein: 2-185
Range on HMM: 73-258/273.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG---TQIYGFFEITLHSIREYPDYILRELKIVDSRDAEgsSQHVKQ
| . ..|||||||||.|..||||||||.....|||| .. |.|.  |..|||..|   ...|| | .|| |. ...||..|.|..... . |  | .|..
ynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvth

FQYVSWPSKGVPDSAIGLLDVREQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|.| .||  |||.|   ||.  |.|.|... . ...|.|||||.|.|||||.||. ||.|||..|| |||...|. || |||||| ..
fhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2-184 2.4e-65 215.2 In-house 48-227 (250) alignment
Range on Protein: 2-184
Range on HMM: 48-227/250.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAmCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIvdSRDAEGSSQHVKQFQY
| .|||||||||||..|. ||||||.|.||.|||||.| .| .|  .|.|||  ....||   ..|.|  |. ||. |.||.  |.  . ....|.|...
yderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllskeefadytkrklkl..skakkaderivrqlhf

VSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
|.|| ||||. |   |.....|.. |. .|..|..|.|| | ||.|..||.  ....|| |  ||||.|.. || .||..|.|
vvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphaves

0039614 (Phosphotyrosine protein) phosphatases II 5-185 2.4e-65 216.2 In-house 100-275 (297) alignment
Range on Protein: 5-185
Range on HMM: 100-275/297.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKaMCHKYWPDSGTqIYGFFEITLHSIREYPDYILRELKIVDsrdaEGSSQHVKQFQYVSW
 ..|||||||||.|..||||||||.....|||| .. |.|. .|..|||..|.  || | .|| .. ....|..|.|....    .| | .|..|||..|
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgw

PSKGVPDSAIGLLDVREQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|  |||.|.  ||.. |.|..... . ...|..||||.|.|||||.||. |...||. || |||...|. || ||||.| . 
pdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp

0036941 (Phosphotyrosine protein) phosphatases II 4-186 7e-65 214.6 In-house 76-264 (297) alignment
Range on Protein: 4-186
Range on HMM: 76-264/297.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS--GTQIYGFFEITLHSIRE--YPDYILRELKIVDSrdAEGSSQHVKQF
  ..|||||||||.|..||||||||.....|||| .. |.|. .|..|||.   ... || | .|| |. .  ..||.||.|...|    .| | .|..|
lkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthf

QYVSWPSKGVPDSAIGLLDVREQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLK---AEGLVDVFQVVRGLRLQRPGMVRSVM
.| .||  |||.|.  |||  |.|.|... . ...|..||||.|.||.||.||. |...||.    || ||....|. || ||||.| ...
hytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle

0045450 (Phosphotyrosine protein) phosphatases II 1-185 1.4e-64 214.1 In-house 102-290 (307) alignment
Range on Protein: 1-185
Range on HMM: 102-290/307.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQ-IYGFFEITLHSIREYPDYILRELKIVDSrDAEGSSQHVKQF
|| . ..|||||||||.| .|||||.||.....|||| .. |.|. .|..||||.|..  || | .|| |. ....|..| |.. |. | .| | .|..|
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthf

QYVSWPSKGVPDSAIGLLDVREQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGL---VDVFQVVRGLRLQRPGMVRSV
.| .||  |||.|   |||  |.|.|..... ...|..||||.|.|||||.||. |...||..||    ||....|. || ||||.| . 
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

subfamily_PTPRA_pd Subfamily PTPRA 1-186 2e-64 212.6 In-house 96-282 (330) alignment
Range on Protein: 1-186
Range on HMM: 96-282/330.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAE--GSSQHVKQ
|| ... |||.|||. .| .|||||.||.||.|||||.. .|| .  |..|||| |.  ||   ....   .  || .|.. . .  ||    .|. |.|
GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrq

FQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDkPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSVM
| . |||  |||  .||.|.. ..|.| .. |.. ||||||| | |||||.|..  .....|||..||||..|. |||||| ||.. .
fhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtde

subfamily_PTPRB_pd Subfamily PTPRB 1-184 7.8e-64 210.5 In-house 89-270 (293) alignment
Range on Protein: 1-184
Range on HMM: 89-270/293.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS-GTQIYGFFEITLHSIREYPDYILRELKIVDsrdaEGSSQHVKQF
||  .. |||||||||.|.||||||||| |||.|||| .  |.||  |..|||.   ...||  ..|| . .|. |...|||||      | ....|.|.
gynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqy

QYVSWPSKGVPDSAIGLLDVREQVEKWQ-RDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
...|||  |||...  |||  ..|.... ... ..||||||| | |||||.||.  |..... | .||.| .|  || .|  .| .
hftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqt

0043336 (Phosphotyrosine protein) phosphatases II 3-185 1.3e-63 210.4 In-house 85-263 (278) alignment
Range on Protein: 3-185
Range on HMM: 85-263/278.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPdSGTQIYGFFEITLHSIREYPDYILRELKIVDsrDAEGSSQHVKQFQYV
 . ..|||||||||.|..||||||||....||||| .. |.|.  |..||| .|.. || | .|| .. ...||..| |....    .| |..| ...|.
nvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhyl

SWPSKGVPDSAIGLLDVREQVEKWQRdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.||  |||.|   |||  ..| .... . ..|..||||.|.|||||.||. ||..||. || ||....|. || ||||.| . 
gwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp

0040439 (Phosphotyrosine protein) phosphatases II 3-185 7.5e-62 204.5 In-house 51-232 (249) alignment
Range on Protein: 3-185
Range on HMM: 51-232/249.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSrdAEGSSQHVKQFQYV
   ..|||||||||.|..|||||.||.....|||| .. |.|.  |..|||..|.. || | .|| |. ...||..|.|.....   .|.| .|...||.
yikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqyt

SWPSKGVPDSAIGLLDVREQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.||  |||.|   |||  |.|.|....   ..|..||||.|.|||||.||. |...||. |. ||....|. || ||||.| . 
dwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp

DSPc_SM00195 4-185 1.2e-61 203.7 In-house 67-248 (263) alignment
Range on Protein: 4-185
Range on HMM: 67-248/263.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS--GTQIYGFFEITLHSIREYP-DYILRELKIVDSRDaeGSSQHVKQFQ
|.|..||||||||.| .|||||||| |...|||| .| |.||  |..|||..  |.. .| ....| .  ... ..|||.|..    .    .. |.|.|
kkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyq

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
| .|| .|||||.  .|.. ..|.|... | ..||||||| |.|||||.... .....|..|  ||.|..|. || ||||||.. 
yknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

PTPc_SM00194 4-185 1.2e-61 203.7 In-house 67-248 (263) alignment
Range on Protein: 4-185
Range on HMM: 67-248/263.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS--GTQIYGFFEITLHSIREYP-DYILRELKIVDSRDaeGSSQHVKQFQ
|.|..||||||||.| .|||||||| |...|||| .| |.||  |..|||..  |.. .| ....| .  ... ..|||.|..    .    .. |.|.|
kkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyq

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
| .|| .|||||.  .|.. ..|.|... | ..||||||| |.|||||.... .....|..|  ||.|..|. || ||||||.. 
yknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

0042113 (Phosphotyrosine protein) phosphatases II 3-185 1.6e-61 203.2 In-house 49-229 (245) alignment
Range on Protein: 3-185
Range on HMM: 49-229/245.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDsrDAEGSSQHVKQFQYV
   . |||||||||.|..|||||.||....||||| .| |.|.  |..|||..... || | .|| |.  ..||..|.|....  . .. |..| ...|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtn..lgddesrevihyhyl

SWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.||  ||||.   |||. | |.|........|..||||.|.|||||.||. |...||..|. |.....|. || ||||.| . 
pwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtp

0045098 (Phosphotyrosine protein) phosphatases II 2-185 2.6e-61 202.8 In-house 62-258 (278) alignment
Range on Protein: 2-185
Range on HMM: 62-258/278.0
YckRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDS--RDAEGSSQHVKQF
|  .|.|||||||||.|..|||||.||.....||||... |.|.  |..|||..|...|| |..|| |. ...||.|| |....   ..... | .|...
y..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthl

QYVSWPSKGVPDSA--IGLLDVREQVEKWQR------------DSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLkaEGLVDVFQVVRGLRLQRPG-MVRS
.|..||  |||..     .|.. |.......            .....|..|||| |.|||||..|. |....|  || ||....|. || |||| .| .
hylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqn

V
 
l

subfamily_PTPRK_pd Subfamily PTPRK 1-183 5.9e-61 201.0 In-house 81-261 (314) alignment
Range on Protein: 1-183
Range on HMM: 81-261/314.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQiYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQ
.| . .|||.|||||..|. ||||.|.......||||..  | |.  | ||||. ... || ....| .     ... | ...  .  .    . |.|||
sykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfq

YVSWPSKGVPDSAIGLLDVREQVEKWQRDsGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
...||. .|| || |||..  .|.|.| . .. .|||||| |.|||||.||.. ..| .. ||.||||..|. || ... || 
flgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmve

Y_phosphatase Protein-tyrosine phosphatase 4-185 7.5e-61 200.9 Pfam-A 40-223 (235) alignment
Range on Protein: 4-185
Range on HMM: 40-223/235.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWP--DSGTQIYGFFEITLH-SIR-EYPDYILRELKIVDSRDAEgSSQHVKQF
. |.||||||||..| .|||||||..|...||||... |.|.  |..|||  ..... || ....|  ..  .  .|.||.|.. .. . .  ...|||.
ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkql

QYVSWPSKGVPDSAIGLLDVREQVEKWQrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.| .|| .|||.|. .|||. ..|||.. .. ..|.||||| |.|||||..|. .|..||.||. |||.|.|. || |||||| |.
hytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

Y_phosphatase Protein-tyrosine phosphatase 4-185 7.5e-61 200.9 In-house 40-223 (235) alignment
Range on Protein: 4-185
Range on HMM: 40-223/235.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWP--DSGTQIYGFFEITLH-SIR-EYPDYILRELKIVDSRDAEgSSQHVKQF
. |.||||||||..| .|||||||..|...||||... |.|.  |..|||  ..... || ....|  ..  .  .|.||.|.. .. . .  ...|||.
ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkql

QYVSWPSKGVPDSAIGLLDVREQVEKWQrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.| .|| .|||.|. .|||. ..|||.. .. ..|.||||| |.|||||..|. .|..||.||. |||.|.|. || |||||| |.
hytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-184 6.1e-60 197.7 In-house 87-264 (288) alignment
Range on Protein: 3-184
Range on HMM: 87-264/288.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT-QIYGFFEITLHSIREYPDYILRELKIVdsrdAEGSSQHVKQFQY
 |.|..|||||||.|| .|||..|.|.|.||||||..  |.||  |..||||... . || ...|| . .|  |..||.| ..     ...  ...|.||
kkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqy

VSWPSKGVPDSAIGLLDVREQVEKWQRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
 .|| .|||.|.  ||....||.  . .   .||.|||| | |||||.||.  |||....|  .||. .|  || ||. .|  
laWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqt

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-185 8.8e-60 197.0 In-house 86-269 (290) alignment
Range on Protein: 1-185
Range on HMM: 86-269/290.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAeGSSQHVKQFQ
|| ..|..||||||...|  |||...|. |.. |||| |. | ||  |..|||||.|. || |.|.|.. ... .|| |.|.. ... | |..|.|.|.|
gykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyq

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
  .|.|.|      . | | |...| || .|...||||||.. ||.....|.   |.. | || .|||||.. .| |.||.| .|
itnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtv

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-185 4.2e-58 192.1 In-house 99-277 (319) alignment
Range on Protein: 1-185
Range on HMM: 99-277/319.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLAnerergKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEgSSQHVKQFQ
|| ... .||.||||..| .|||||.|||..||||.|.      | .| .|||  . . .. |.. ..|. |  .|..|.... .    .   ....|| 
GyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkek.dirkitqfh

YVSWPSKGVPDSAIGLLDVREQVEK-WQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.  || .||||... |. . ..|..  ..  . ..|||||| |.||||.||..  |.|..| |  |||...||.|| ||. .|...
flGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-185 4.5e-58 191.6 In-house 80-262 (281) alignment
Range on Protein: 2-185
Range on HMM: 80-262/281.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG-TQIYGFFEITLHSIREYPDYILRELKIvdsRDAEGSSQHVKQFQ
| . |..||||||.|.. ..||.||||.| |.|||...| | ||  ||.||||   . .|| . .. .. .| . || |..|.   .  .| ...|.|..
ykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl...eresgetreveqla

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAE-GLVDVFQVVRGLRLQRPGMVRSV
|..|| .|||...  ||. |..|.| .. . . |.|.||| | ||||||||.  |.....||   .|| .||. || .|  ||..|
ytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv

subfamily_Ptp69D_pd Subfamily Ptp69D 1-184 6.7e-58 191.2 In-house 86-271 (307) alignment
Range on Protein: 1-184
Range on HMM: 86-271/307.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDA---EGSSQHVK
|| ..| ||| |.|.  | .|||||..| .. .||||.|. |  .. |.||||.  .. ||   ..| | .. .||| |||..    .    .  |..| 
gykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvv

QFQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
|..| .|.   ||..| |||.. |||.. .. .   ||||||| | ||.|...|...|..|||||  ||.|..|..|| ||. .|.|
qyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-185 1.8e-57 190.0 In-house 63-241 (284) alignment
Range on Protein: 1-185
Range on HMM: 63-241/284.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLAnerergKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEgSSQHVKQFQ
|| ... .|||||||..| .|||||.|||..||||.|.      | .| .|||  . . .. |.. ..|. |  .|..|.... .    .   ....|| 
GyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkek.dirkirqfh

YVSWPSKGVPDSAIGLLDVREQVEK-WQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.  || .||||... |. . ..|..  ..  . ..|||||| |.||||.||..  |.|..| |  |||...||.|| ||. .|...
flgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

0037934 (Phosphotyrosine protein) phosphatases II 7-184 1.3e-56 187.2 In-house 45-227 (243) alignment
Range on Protein: 7-184
Range on HMM: 45-227/243.0
AFIATQGPLPDTTDD----FWRMVWEYKSSTIVMLANERERGKAMCHKYWPdsGTQIYGFFEITLHSIREYPDYILRELKIVDsRDAEGSSQHVKQFQYV
 .||||||||.|..|    ||||.||.....|||| .. |.|.  |..|||  |.. || |..|| |.....||..|.|...   |... ...| ...|.
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygdftvtllseehlddytvrtlllen.ldlddltrlvihyhyl

SWPSKGVPDSAIGLLDVREQVEKWQRD-------SGDKPIVVHCSGGCGRTGTYIAMCLLIDQLkaeGlVDVFQVVRGLRLQRPG-MVRS
.||  |||||   |||  ..| .....       ....|..||||.|.|||||.||. |....|   | ||....|. || |||| .| .
pwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqt

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-185 3.6e-56 185.3 In-house 81-264 (287) alignment
Range on Protein: 1-185
Range on HMM: 81-264/287.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRdAEGSSQHVKQFQ
|| ..||||....|. .|  .||..... . ..||||..|.|  . .|..|||.. . ..| ..|.| .   . .|| |.|..  .   .|. |.|||.|
gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn.kagdkqqvkqyq

YVSWPSKG-VPDSAIGLLDVREqVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
. .|.|.| |.. .  || . |   | || .|. .|||||| . ||.....|.   |.. | || .|||||..  | |.||.|. |
itnWdstgkvtepqtillviee.myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-185 5.8e-56 184.7 In-house 87-265 (315) alignment
Range on Protein: 1-185
Range on HMM: 87-265/315.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSgTQIYGFFEITLHSIREYPDYILRELkivdSRDAEGSSQHVKQFQ
|| |.. .||.|||.. . .||||.|.|.. ..||||.|  |. | .. |||||    ||| . .|. |   . .|  | |    |   .   ..| |..
Gynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl....svvfgdnirevvqlh

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGdKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
| |||  ||| ..| |...  .| ... .|   .|||||| | |||||.|..  ..||..|| ..||.....|.| .| .||...
ytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqva

subfamily_PTPRG_pd Subfamily PTPRG 1-183 8.5e-56 184.3 In-house 86-271 (563) alignment
Range on Protein: 1-183
Range on HMM: 86-271/563.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEG----SSQHV
|| | ||||||||||.||.||||||.|| ....|||..|  |||.  |. |||  ... || ...|| .      |  |.|.| . .  ..    . ..|
GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklv

KQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRD-SGdkPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
.|..| .|| .|||....  |   .. .. ...  |  ||||||| | |||||||..  |. |...|  |.||.... .|.||. .| 
rqyhytkWPdhgvPehslpvLifvkkssaankaeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvq

subfamily_PTPN12_pd Subfamily PTPN12 4-183 8.1e-55 180.7 In-house 81-261 (290) alignment
Range on Protein: 4-183
Range on HMM: 81-261/290.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS-GTQI-YGFFEITLHSIREYP-DYILRELKIVDSrdaeGSSQHVKQFQ
.....||.|||||.| ||||||.||.. . .||. .| | ||  |..|||.. .... .| ||.||.. .    |...| ||.  .    . |..|.||.
gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfh

YVSWPSKGVPDSAIGLLDVREQVEKWQRdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGL---VDVFQVVRGLRLQRPGMVR
| .|| .||| ||  ||.. |.|.. |. | |.|.||||| |.||||| ||. .  ..|||| .   .|||..|. || ||. .|.
YtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvq

subfamily_PTPN6_pd Subfamily PTPN6 5-183 5.7e-54 178.2 In-house 97-281 (306) alignment
Range on Protein: 5-183
Range on HMM: 97-281/306.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQ-IYGFFEITLHSIREYPDYILRELKIVDsRDAEGSSQHVKQFQYVS
.|..||||| |..|  |||||||. .|  |||. .| |||| .| .||||. ..  ||  ..|  | ..  |||||||..   .. ......| |... |
dksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvsk.kkkkkeerevfqyhfks

WPSKGVPDSAIGLLDVREQVEKWQRDSG---DKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGL---VDVFQVVRGLRLQRPGMVR
|| .||| .   .||  |.|.. |...      ||||||| | |||||.| . .|..... .||   .|. ..|. .| || |.|.
WPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvq

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4-183 3e-53 175.7 In-house 71-252 (274) alignment
Range on Protein: 4-183
Range on HMM: 71-252/274.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQ----IYGFFEITLHSIREYPDYILRELKIVDSRDaegsSQHVKQF
. ||..||||||| | .|||||... ... ||||.. .|. .. |..|.||.        || .||. ..| |  || .|.| .  . .    ...|| .
eskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler....ersvkhy

QYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDK--PIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
 | .|| . .||.|  |||. ..||. ....  |  |.||||| | |||| .||. . . ||..|. |||...|  |||.| |||.
wytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvq

subfamily_PTPN3_pd Subfamily PTPN3 6-184 1.3e-52 173.4 In-house 84-260 (280) alignment
Range on Protein: 6-184
Range on HMM: 84-260/280.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT-QIYGFFEITLHSIREYPDYILRELKIVDSRDAEgsSQHVKQFQYVSW
. .|||||||..|. |||.|||| |||.||||..  |||.  ||.|||...  . || |...... .|   |.|||| . |..  |  .... |.||..|
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketke..erkilqlqylaW

PSKGVPDSAIGLLDVREQVEKwQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
| .||||..  .|.. |.|.| .| . ..|.|||||.| |||| .|.. . .  . |.  | . ..|| .| ||  .|..
pdhgvPddsadflefvervrk.lrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqt

subfamily_PTPN9_pd Subfamily PTPN9 1-181 1.9e-51 169.9 In-house 80-272 (297) alignment
Range on Protein: 1-181
Range on HMM: 80-272/297.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPD--SGTQIYGFFEITLHSIREYPDYILRELKIVDSRDaeGSSQHVKQ
|| ..||||||||||. |..|||||||| .  .||| .   |||.  | .|||.    .. .|.....  ...|. ||  | |.| ....  . |..|  
GykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt..eesrkvth

FQYVSWPSKGVPDSAIGLLDVREQVEK------------WQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGM
||..|||  |||.||  ||||.|.| .            |. .  . ||||||| | |||||.|.. . ...|. .| |||...|. || ||  .
fqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafs

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1-183 3e-51 168.9 In-house 80-277 (301) alignment
Range on Protein: 1-183
Range on HMM: 80-277/301.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGF--FEITLHSIREYPDYILRELK--IVDSRD--------
|| ..|.|||.|||.  |  ||||..|..| ..|||..|..|. |. |..|||.| .. . |  |..||..   |||...|.|.  | |. .        
gysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkf

---AEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
   .. ||..| |.| ..||  ||       | | ..| . |.  |  |.||||| . .|.|.|... . ..| |||| ||||||.. .| ..||.| 
kvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVt

subfamily_PTPN13_pd Subfamily PTPN13 7-183 8e-51 167.9 In-house 78-253 (273) alignment
Range on Protein: 7-183
Range on HMM: 78-253/273.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG---TQIYGFFEITLHSIREYPDYILRELKIVDSRdaEGSSQHVKQFQYVS
 .||.|||||.|..|||.|||| |.. |.|...|.|.||  ||.|||.|    ..... .|..|  . .. .. .|.|.. ||.   | |..| ....|.
eyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse..sgesrevahlnfvk

WPSKGVPDSAIGLLDVREQVEKWQRDSGdkPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
||  ||| ||  || .  .| . |.|.|  ||||||| | ||.||.|..  ... .. .  .|| ..|| || || |.|.
wPdhgvPssaaellqfvaevrrlqtdag..PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvq

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-185 1.4e-48 160.7 In-house 88-274 (325) alignment
Range on Protein: 3-185
Range on HMM: 88-274/325.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKsSTIVMLANERERGKAMCHKYWPDS--GTQIYGFFEITLHSIREYPDYILRELKIVDSRdaEGSSQHVKQFQ
 |.. |.|.| ||..|..|.||.| ... ...|.. || . ||  | .|||.    .. .| .|. | .| |. ||. | |.. . .  .| .. |||||
kkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk..kGetrsvkqfq

YVSWPSKGVPDSA---IGLLDVREQVEKWQRD--SGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
. ||.  ||.      | .|.. ..|..  .    .  ||.|||| | ||||..|..  .....  |  ||.|..|. || .|| ||..|
lqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetv

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 5-183 1.5e-48 160.5 In-house 91-268 (297) alignment
Range on Protein: 5-183
Range on HMM: 91-268/297.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKaMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIvdSRDAEGSSQHVKQFQYVSW
.. .|.|| | ..| .|||.||.... ||||||... || |  | .||.|.|.. .|   ..|.|. |   .| |||..  ....  . . |||.|.|.|
khrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelev..tkgkakarrvvkqyqfveW

PSKGVPD--SAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
|.| |.   ||  ||.. ..|.|   .  . |..|||. | |||| ....   . . | |  ||.|..|. || .|| .|.
PdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvq

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 4-184 5.3e-48 158.3 In-house 73-251 (283) alignment
Range on Protein: 4-184
Range on HMM: 73-251/283.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQhVKQFQYVS
. | .|..|.|| .|  |||.||.. | ..||||.. .|  .  | .|||  |.. || | .||.       .| .|| .  .  |. .   .  .|.. 
qdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvid

WPSKGvPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
| . | ... |  |   ..|   |..| . ||||||| | |||...||.   ......| .||||.||. .| ||...|..
Wleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqt

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 5-183 2.1e-47 156.4 In-house 85-260 (515) alignment
Range on Protein: 5-183
Range on HMM: 85-260/515.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPD--SGTQIYGFFEITLHSIREYPDYILRELKIVDSRDaegsSQHVKQFQYV
 ||.||.|||.. ..|||||.|.... .||.|... .|  |  | |||||  . .  .| ... | |.    . | |.|... . |    |. | ||.. 
dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd....srtvtqfhft

SWPSKGVPDSAIGLLDVREQVeKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
 || ||||  .  || .  .| | ...    |...||| | |||| .|..   . . |    ||||..|. .| .|| .|.
eWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvq

subfamily_PTPN23_pd Subfamily PTPN23 7-185 2.9e-47 155.9 In-house 84-266 (288) alignment
Range on Protein: 7-185
Range on HMM: 84-266/288.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS--GTQIYGFFEITLHSIREYPDYILRELKIVDSRdAEgSSQHVKQFQYVSW
 |||||.||. |  |||.||.| |||.|||| .. |.||  ...||| .   |. .| ...||.| || . .. |.||.   . |.   ..|.  |. ||
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld.ad.avksvshlqltsW

PSKGVPDSAIGLLDVREQVEK---WQRDSGDKPIVVHCSGGCGRTGTYIAM-CLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|. |||.|   ||.. ..||.    ..   ..|.||||| | ||||..  . . ...  | .||.|. |||. || ||  ||. .
pelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqek

subfamily_PTPRN_pd Subfamily PTPRN 5-184 4.2e-47 155.3 In-house 99-277 (297) alignment
Range on Protein: 5-184
Range on HMM: 99-277/297.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREY-PDYILRELKIVDSRDAEgsSQHVKQFQYVS
. |.|||||||..|  |||.||||  .  ||.|.. .| |   |..|||| |...|...|. | |   .  ||..| . . . .  |  .. | || ..|
apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse..trtvtqfhfls

WPSKGVPDSAIGLLDVREQVEKWQRDsGDKPIVVHCSGGCGRTGTYIAMCLLIDQL-KAEGLVDVFQVVRGLRLQRPGMVRS
||..||| ||  ||. | .|.|  |     |||||||.|.||||.||.. |....| |    .|.   .  || ||||.|..
wpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvkt

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 5-183 2.4e-46 153.1 In-house 86-261 (315) alignment
Range on Protein: 5-183
Range on HMM: 86-261/315.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPD--SGTQIYGFFEITLHSIREYPDYILRELkIVdsRDAEgSSQHVKQFQYV
 ||.||.||||. . |||||||...| .||||... .|  |  | .||||  . .  .| ....| |.    | . |.| ..  |..| .|. | |||. 
dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt..rkse.esrtvtqfqft

SWPSKGVPDSAIGLLDVREQVEKWqRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
 || |||.  .  || .  .|    ... . ...|||| | ||||  |..   ..|.| .  ||||..|. || .|| .|.
ewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvq

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-185 5.6e-46 151.9 In-house 86-265 (439) alignment
Range on Protein: 1-185
Range on HMM: 86-265/439.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKamchkYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQ
|| . | .||||||  .|||||||.|.| |..|||||.|  |  |     ||| ..  .||   .      | |.|..| .|... ||     . | ||.
Gyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfh

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|..|| | ||  |  .||    ..  . .    |.||||| | ||||| ||. . ..|||.|  ||.  .|. || ||  ||...
yiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqal

subfamily_CG7180_pd Subfamily CG7180 1-185 2.8e-45 149.2 In-house 80-276 (296) alignment
Range on Protein: 1-185
Range on HMM: 80-276/296.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKaMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDS--------RDAEGS
.. | |..| |..|  .| |.|||.|.. ..|..|.|... .  | |...|||  . . || ... . . ..|..   |..|..          .. .  
sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkae

SQHVKQFQYVSWPS-KGVPDSAIGLLDVREQVEKWQRDS----GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
   ||.||.  |.. . || |. .|...|..|..|..        .|.||..| | .|.| |.|.   ..... |. ||||. |. || .||..| .|
tRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenv

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-185 2.8e-45 149.3 In-house 75-263 (287) alignment
Range on Protein: 1-185
Range on HMM: 75-263/287.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT--QIYGFFEITLHSIREYPDYILRELKIVDsrdAEGSS-QHVK
.| . .||||.|||.. |  ||||.|.| .|....... | | ..  |.||||.     .. |.  . |      |.|  | |...|   .|.   . ||
sytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlid...letrearvvk

QFQYVSWPSKGVPDSAIGL----LDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|....|||.|... .|.||    |||....|  .  |.  |.|||.. | ||.|...|.  |...|.  | ||| .||  || .| ..|..|
qldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

0051429 (Phosphotyrosine protein) phosphatases II 3-186 3.9e-45 149.9 In-house 19-212 (272) alignment
Range on Protein: 3-186
Range on HMM: 19-212/272.0
CKRKAFIATQGPLPDTTDDFWRMvWEYKSSTIVMLANERERGKAMCHKYWP------------DSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAE
 |........|||| | .||||. .|.. .|||.| .| |||.  |..|||            .  |  ||.. .||.|.  ..||||||| ..   .|.
vkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

GSsQHVKQFQYVSWPSKGVPDSAigLLDVREQVEKwqrdsgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVD--------VFQVVRGLRLQRPGMV
 .  .| ...| .||  |||..|  ||.. |.. .      ..|..||||.|..||||..|. ||. .. .|  ||        ....|. || ||||.|
ea.revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgav

RSVM
 . .
qtee

0036282 (Phosphotyrosine protein) phosphatases II 5-184 3.3e-44 146.0 In-house 16-155 (174) alignment
Range on Protein: 5-184
Range on HMM: 16-155/174.0
RKAFIATQGPLPdttddFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDsgtqiygffeitlhsireypdyilrelkivdsrDAEGSSQHVKQFQYVSW
 . .||.||||.     ||.|..|....|.||| .|.|.|. .|. |||.                                 . |  .... |..|. |
tprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lredlerlgiqylylpw

PSKGVPDSAIgLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKaEGLVDVFQVVRGLRLQRPGMVRS
|  ||||..| ||.. ..||... .....|..||||.|.||||| .|. |.. .|. |.|||....|| ||||||||| .
pDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 5-183 4.3e-42 139.0 In-house 44-223 (237) alignment
Range on Protein: 5-183
Range on HMM: 44-223/237.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG-TQIYGFFEITLHSIREYPDYILRELKIVDSRDAEgSSQHVKQFQYVS
 | .||.||||  . ||||.|||. | | ||||.   |. .  ||||||..   . || . ..|.   |. || .| | ..     .   . ..|.|. |
pkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlk.evrlihqyqfts

WPSKGVPDSAIGLLDVREQVEKWQRD-SGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
|| .|||. .  ||  | .. .  .  |   | ..||| | |||| .. .  .. | | . .||... |  .  .|| ...
wpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiq

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4-184 6.7e-42 138.3 In-house 62-249 (270) alignment
Range on Protein: 4-184
Range on HMM: 62-249/270.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQ----IYGFFEITLHSIREYPDYILRELKIVdsrdAEGSSQHVKQF
..|..||..|||| |. .||||.|| |...|||...  |.|.  | .||| .  .     .|. ...  | .    |||..|..      .|.....  |
ekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle....ekgeerrlvHf

QYVSWPSKGVPDSAI------GLLDVREQVEKWQRDSGDK-PIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
.|..|| .||| ..        || . ..| .....  .. |..|||| | ||||| ||.   .  |. .. ||| .... || .|. .|. 
wyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqh

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 5-184 1.5e-41 137.1 In-house 51-226 (239) alignment
Range on Protein: 5-184
Range on HMM: 51-226/239.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSgTQIYGFFEITLHSIREYPDYILRELkiVDSRDAEGSSQHVKQFQYVSW
 ||.||||| .  .. |||||.|. .   ||||.   |  |  ||.||||| |  |  . .||.    . |||.| .  | |.  .   ..| |...  |
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskycnlrvtlrktevfadyiirtf..vmsqvgqteeryvyqyhftvw

PSKGVPDSAIGLLDVREQVEKWQrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
| ||||. |  .| .| .. |     | .| |.||| | ||||... .  .. | | .  ||.|. |. .| .|| ||..
pdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqt

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 5-184 1.5e-41 137.1 In-house 50-225 (239) alignment
Range on Protein: 5-184
Range on HMM: 50-225/239.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSgTQIYGFFEITLHSIREYPDYILRELkiVDSRDAEGSSQHVKQFQYVSW
 ||.||||| .  .. |||||.|. .   ||||.   |  |  ||.||||| |  |  . .||.    . |||.| .  | |.  .   ..| |...  |
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskycnlrvtlrktevfadyiirtf..vmsqvgqteeryvyqyhftvw

PSKGVPDSAIGLLDVREQVEKWQrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
| ||||. |  .| .| .. |     | .| |.||| | ||||... .  .. | | .  ||.|. |. .| .|| ||..
pdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqt

0049260 (Phosphotyrosine protein) phosphatases II 2-184 9.2e-39 127.9 In-house 5-135 (152) alignment
Range on Protein: 2-184
Range on HMM: 5-135/152.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWpdsgtqiygffeitlhsireypdyilrelkivdsrdaegssqhvkQFQY
| . ..|||||||.| |..|||||..|.. .||||| .. |.||  |..|.                                             |...
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylh

VSWPSKGVPDSAIGLLDVREQVEKWqRDSGDKPIVVHCSGGCGRTGTYIAMCLLIdqlkaeGLVDVFQVVRGLRLQRPGMVRS
. ||  ||||... ||.. . .||. . . ..|..||||.|.|||||..|. |..        |.....|. .| .|||.| .
lpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpn

subfamily_PTPN14_pd Subfamily PTPN14 4-185 1.5e-38 127.5 In-house 91-282 (300) alignment
Range on Protein: 4-185
Range on HMM: 91-282/300.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS----GTQIYGFFEITLHSIREYPDYILRELKIVDSRdaEGSSQHVKQF
|.. .|..||||. |  |||.|||| . . ||||..|.| ||  ..||.|..     |  .| |..| .  .. . .| . ||.       .  . |  .
kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp..skeertvwhl

QYVSWPSKGVPDSAIGLLDVREQVEKWQRDS--------GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
||. || .|||.   | |.  |.|.  .| .         . |..|||| | ||||  |   |||  |. .  .|. .|.. || ||  .|...
qytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl

subfamily_PTPN1_pd Subfamily PTPN1 5-183 2.1e-37 123.4 In-house 70-255 (290) alignment
Range on Protein: 5-183
Range on HMM: 70-255/290.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT---QIYG--FFEITLHSIREYPDYILRELKIVDSRDAEgsSQHVKQF
.. .| ||||||.|.| ||.|||| || ..||| .  |...  |..|||        ..    ....| |  ..  |..| |.. . .  |  .... .|
krsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqe..treilhf

QYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGD-KPIVVHCSGGCGRTGTYIA--MCL-LIDQLKAEGLVDVFQVVRGLRLQRPGMVR
 |..||  |||.|   .|.   .| .    | |  | |.||| | ||.||..    || ||.. .    ||. .|.  || .| |...
hyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliq

0041856 (Phosphotyrosine protein) phosphatases II 1-184 3.9e-37 123.0 In-house 29-156 (182) alignment
Range on Protein: 1-184
Range on HMM: 29-156/182.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLAnerergkamCHKYWPdsgtqiygffeitlhsireypdyilrelkivdsrdaEGSSQHVKQFQ
|... . ||||||||..|. ||.||..|.. .|||.|.         .. |||                                    |   ... |..
gslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp....................................ellerlgiqyl

YVSWPSKGVPDsAIGLLDVREQVEKwqrdsGDKPIVVHCSGGCGRTGTYIAMCLLIDQlkaeGlVDVFQVVRGLRLQRPGMVRS
|..||  ||||    |||  |.|..      ..|..||||.|.|||||..|. |.. .    | |.....|. .| .||||| .
ylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvit

0043147 (Phosphotyrosine protein) phosphatases II 2-185 1.6e-36 121.0 In-house 16-147 (172) alignment
Range on Protein: 2-185
Range on HMM: 16-147/172.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANErergkamchkywpdsgtqiygffeitlhsireypdyilrelkivdSRDAEGSSQHVKQFQY
| . . ||||||||. |..|||||..|.. ..||.| ..                                               |.|. .... |..|
yyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydpellerlgiqyly

VSWPSKGVPdSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIdqlkaEGLvDVFQVVRGLRLQRPGMVRSV
..||  ||| ..  ||.. |......  | ..|..||||.|.||||| .|. |..     .|| .....|. .| .|||.| . 
lpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnp

0046846 (Phosphotyrosine protein) phosphatases II 7-184 3.6e-36 119.9 In-house 24-158 (176) alignment
Range on Protein: 7-184
Range on HMM: 24-158/176.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDsgTQI--YgffeitlhsireypdyilrelkivdsrdaegssqhvkQFQYVSW
..||||||||.|. ||..|..|.. ...|.| .|.| |.  |. |||.   .   .                                     |.... |
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.....................................qylhlpw

PSKGVPDSaIGLLDVREQVEKWQRDSgdKPIVVHCSGGCGRTGTYIAMCLLIDqlkaEGLVDVFQVVRGLRLQRP-GMVRS
|  ||||.   ||.. |........   .|..||||.|.|||||..|. ||.     |  ..|..... .| ||| |.| .
pDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqt

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 6-182 1.3e-34 114.2 In-house 94-266 (290) alignment
Range on Protein: 6-182
Range on HMM: 94-266/290.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIRE-YPDYiLRELKIVDSRDA-EGSSQHVKQFQYVS
  || |||.| ||. |.|||| . | ..|||| .  | ||| |..|.|.   ..  | |||.    |  .|     .|..  ||  .| .  .| .. .|
amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkda.niikktlsvrdkdsGkehklkhlkiks

WPSKGVPDSAIGLLDVREQVEKWqrdSGdkPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMV
|| | |. |.. || .   . |    ||  |.||||| | |||||..|.   .. |     .|. ..|| ||  | . |
wpdksvalstlallrtlrilrka...sG..pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsv

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 6-180 3.1e-34 113.1 In-house 90-262 (301) alignment
Range on Protein: 6-180
Range on HMM: 90-262/301.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIY--GFFEITLHSIREY--PDYILRELKIVDSRDaEGSSQHVKQFQY
. ||||||||..|..||| |.  |.  .||||....|. . .|..| | . ..    | |.|....       . . |.|...|| . . ... |  .||
hrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg.kfatrtvthyqy

VSWPSKGVPDSAIGLLDVREQVEKwqrdsGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPG
..|. .||| | . | |. | | |      .|||||||| | ||. ..|.   |  ...|.  ... . .. || .|  
sewtdrgvPkshaelfdlmelvkk.....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwn

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 5-185 9.8e-33 108.0 In-house 4-190 (199) alignment
Range on Protein: 5-185
Range on HMM: 4-190/199.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWP--DSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQYV
.. .|||| || .|  |||.||||  |  |||. ...   .|    |||  .|||  || . .| ..|   ||| .  | ....  |  |.. . ..|. 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPSKGVPDSAI--GLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQL--KAEGLVDVFQVVRGLRLQRPGMVRSV
||  |  |. |.  |..    .| |   .  | |..|||| | | || ..|. . .         .||.|.| . ||  | |.. |.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 6-185 1e-32 107.9 In-house 4-189 (198) alignment
Range on Protein: 6-185
Range on HMM: 4-189/198.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWP--DSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQYVS
. .|||| || .|  |||.||||  |  |||. ...   .|    |||  .|||  || . .| ..|   ||| .  | ....  |  |.. . ..|. |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPSKGVPDSAI--GLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQL--KAEGLVDVFQVVRGLRLQRPGMVRSV
|  |  |. |.  |..    .| |   .  | |..|||| | | || ..|. . .         .||.|.| . ||  | |.. |.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl

0051082 (Phosphotyrosine protein) phosphatases II 8-184 1.5e-31 104.4 In-house 15-138 (151) alignment
Range on Protein: 8-184
Range on HMM: 15-138/151.0
FIATQGPlpdtTDDFWRMVWEYKSSTIVMLANERERGkaMCHKYWPDSGtqiygffeitlhsireypdyilrelkivdsrdaegssQHVKQFQYVSWPSK
.....||    ..||.....|.. .|||.| .| |||  .|..|.|. |                                      .|.......||  
lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.....................................ievlhipildwpdp

GVPDSAIGLLDVREQVEKwqrdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQlkaeglVDVFQVVRGLRLQRPGMVRS
|.|.|   .|.. |....     ...|..||||.|.||||| .|. |.. .      |....... .||.|||.|..
glplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp

0049772 (Phosphotyrosine protein) phosphatases II 6-183 2.1e-30 102.0 In-house 84-264 (314) alignment
Range on Protein: 6-183
Range on HMM: 84-264/314.0
KAFIATQGPLPDTTDDF----------WRMV--WEYKSSTIVM---------------------LANERERGkamchKYWPDSGTQIYGffeitlhsire
..||||||||. | .||          ||||  ..... .|||                     | .  ..|      ... .  . .            
lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk...........

ypdY-------IlrelkivdsrdaegsSQHVKQFQYVSWPSkGVPDSAIGLLDVREQVEKWqrdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKaeglV
                           .... .. .. .|  | ...   .... | .|..   . ..|..|||..|.|||||......|. .|.    |
...eelydpelf...............erlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....v

DVFQVVRGLRLQRP-----GMVR
.. .... .||.||     |...
sleealedvrlkRpinpnpgfie

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 5-183 6.6e-30 98.8 In-house 87-220 (392) alignment
Range on Protein: 5-183
Range on HMM: 87-220/392.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGkamchkywpdsgtqiygffeitlhsireypdyilrelkivdsrdAEGSSQHVKQFQYVSW
 ||.||.||| . . |||||||.. . .||.|... .|                                                 . . | ||... |
ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............................................kgddartvaqfhftew

PSKGVPDSAIGLLDVREQVeKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
| |.||  .  || . ..| | .  .  .|...||| | ||||  |..  .. . |   .||||..|  .| .|| ||.
Pdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvq

PTPc_DSPc_SM00012 96-185 3e-29 96.7 In-house 2-93 (105) alignment
Range on Protein: 96-185
Range on HMM: 2-93/105.0
VKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSG-DKPIVVHCSGGCGRTGTYIAMCLLIDQLKAE-GLVDVFQVVRGLRLQRPGMVRSV
||...| .|| .|||...  .|.. ..|.|....|.  ||.||||| |.|||||..|...|..||..| . ||.||.|. || ||||||.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte

subfamily_ptpA1_pd Subfamily ptpA1 5-159 1.9e-28 94.3 In-house 88-256 (418) alignment
Range on Protein: 5-159
Range on HMM: 88-256/418.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS-----------GTQIYGFFEITLHSIREYPDyilRELKIVDSR-DAEGS
 | ||.||||||.|  |||||||| .   ||||. | |  .  | .|||.            | ...| . . |  . . |.   ||.   . |   || 
pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe...reiitrnirltfege

SQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRD---SGD--KPIVVHCSGGCGRTGTYIAMCLLIDQL
.. . |.||  || . .|| .  . ..   . . | .   | |   ||.|||| | |||||. .  ... .|
trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4-180 4.1e-28 93.3 In-house 80-258 (307) alignment
Range on Protein: 4-180
Range on HMM: 80-258/307.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFE----ITLH---SIREYPDYILRELKIVDSrDAEGSSQHV
| | ||..|||| .|  .|| |. . |  ...||..  | .|  |..|||    |   | |    |..    . .  ||  | ..  ..  |  . |. .
kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkv.dwaqksrti

KQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrdsGDKPIVVHCSGGCGRTGTYIAMCLLIDQL-KAEGLVDVFQVVRGLRLQRPG
...|.  || .|||.  .. ... | |.         |.||||| | ||.|| .|..|. |.. . .   |. ..|. || ||. 
qhlqwenwpdrgvpqinltainlleavry.....dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhy

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1-183 6.2e-28 92.5 In-house 67-243 (267) alignment
Range on Protein: 1-183
Range on HMM: 67-243/267.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANErerGKAMCHKYWPDSGTQIYGFFEITL-HSI-REYPDYILRELKIvdsRDAEGSSQHVKQ
|| ...|||.||.||  |  ||. .. ..| ..||.| .    ..   ...||    |   . ..|. ||. .|  || .  |..   .  . |.. |  
gyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfknesahnvtl

FQYVSWPSKGVPDSAigLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
. |  |  .        |  .   . | | . |..|.||.|| | ||.||.. .   ....| || .|.|. .| .| ||.|.| 
yyykkwnintnnkpy..lkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvd

0044763 (Phosphotyrosine protein) phosphatases II 12-184 5.5e-27 90.0 In-house 35-156 (178) alignment
Range on Protein: 12-184
Range on HMM: 35-156/178.0
QGPlpdttDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTqiygffeitlhsireypdyilrelkivdsrdaegssqhvKQFQYVSWPSKGVPD
..|      |......|.. ..||.|..| |.|.  |..|||..                                          |.... .|  ||||
lpp.....addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipipDhgvpd

SAIGLLDVREQVEKWQRDSGdKPIVVHCSGGCGRTGTYIAMCLLIDQlkaeGLvDVFQVVRGLRLQRPgMVRS
.   .|.. | .|... ..| .|..|||| | ||.|| .|. |.. .    || ....... .| .|| .| .
llehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 6-186 8e-27 88.9 In-house 75-257 (285) alignment
Range on Protein: 6-186
Range on HMM: 75-257/285.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQI--YGFFEITLHSIREY--PDYILRELKIVDSRDAEGSSQHVKQFQY
 ..|.||||||.|  |||.|... | . ..||.   | |   |  |.|.   ..  .| .||||   .|      ||  | .... ||     .... | 
styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqv

VSWPSKGVPDSAIGLLDVREQVEKWQrdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSVM
  || .  |. |  .... . |.| .    .|||.|||| | ||| |.. .     ..  .  ......|| .|  |   |.| |
pwwpdqlapedarpmielykwvkkvn..pkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshm

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 5-178 1.5e-24 81.2 In-house 95-268 (305) alignment
Range on Protein: 5-178
Range on HMM: 95-268/305.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT-QIYGFFEITLHSIR-EYPDYILRELKIVDSR--DAEGSSQHVKQFQ
 | ||..|||| .| |.|| || . |   ||||..  | ||  | .||| .   .      | .  .    |     |..|   .   . . .  |...|
ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlq

YVSWPSKGVPDSAIGLLDVREQVekwqRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEG-LVDVFQVVRGLRLQR
.  || .|||   .  |..   .    | |   ||||||| | ||||| .|.  .....  .     . ..|. || ||
wtewpdrgvppckltslellsai....rgs.kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqr

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 5-178 3.5e-23 76.8 In-house 87-266 (305) alignment
Range on Protein: 5-178
Range on HMM: 87-266/305.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITL-----------HSIREYPDYILRELKIVDsRDAEGSS
 | || || || .|  ||| | .. |  .| || |  |.|   |..|..    ..  | |               ..|.  .  ..| ..|    . ...
pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlvi.egpgeka

QHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwqRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVD-VFQVVRGLRLQR
..|... .. || .||| . . .|.. |.     | |   ||||||| | ||||. . .  ..||| |   ..   .... .| ||
rkvthyhwidwpdrgvpaadlailelleka....rps.kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqr

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 5-178 1.8e-22 74.3 In-house 93-269 (310) alignment
Range on Protein: 5-178
Range on HMM: 93-269/310.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG-TQIYGFFEITLHS--IREYP-----DYILRELKIVDSRDAEGSSQHV
|..|| .||||  |  |||||... .. .|..| .  | |.  |  |||  | |. ||   .|  |    |.        .. .   || . |.     |
rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrv

KQFQYVSWPSKGVPDSAIGLLDVREQVekWQRdsgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQR
.  ..  || .||||     .  |       |     | ||||| | .|... .|. | ||.|.    ||. .|.  |. .|
slikwpnwpdrgvpdekchtvpqrlla..qvr...hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksr

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 5-181 2.4e-22 74.3 In-house 81-253 (288) alignment
Range on Protein: 5-181
Range on HMM: 81-253/288.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYpDYILRELKIVDSRDAEG--SSQHVKQFQYV
.. .| .| ||  | . .|.|. |     ||||..  |.||    .|.|    .   .  .     ... . | . .|.   |  .    .. ||.  . 
krrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr.adidklvkvsllriskegeekvivkilhll

SWPSKGVPDSAIGLLDVREQVekwqrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGM
 |. .|||.. .  | . | .      | .||||||.| | ||||| | . . ...|. .  . . ...  || .|   
eWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfka

0048076 (Phosphotyrosine protein) phosphatases II 67-184 3.7e-22 74.0 In-house 36-128 (145) alignment
Range on Protein: 67-184
Range on HMM: 36-128/145.0
LhsireypdyilrelkivdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSgdKPIVVHCSGGCGRTGTYIAMCLLIDqlkaEGlVD
|                  ... |. .... |..|..||  ||||..  ||.. |..|.....   .|..|||| |.|||||..|..|..     .| |.
l..................tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vs

VFQVVRGLRLQRPGMVRS
...... .| ||||.| .
leealelvrsqrpgavpn

0048179 (Phosphotyrosine protein) phosphatases II 80-184 5.8e-22 73.4 In-house 48-130 (144) alignment
Range on Protein: 80-184
Range on HMM: 48-130/144.0
ElkivdsrdaegssqhVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRdsGDKPIVVHCSGGCGRTGTYIAMCLLIdqlkAEGlVDVFQVVRGLRLQRP
|               . |.....||  ||||..  ||.. | .|....   ..|..||||.|.|||||..|..|..     .| ........ .| .||
e...............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrp

GMVRS
|.| .
gavpn

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 5-177 1.4e-21 71.4 In-house 80-246 (281) alignment
Range on Protein: 5-177
Range on HMM: 80-246/281.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLhsirEYPDYILRELkIVDS---RDAEGSSQHVKQFQY
.. .| ||||  .|  |||||.|. ....||||..  |  .  | .|.|        | ....    .| |  . .  .| .      || .. . .. .
krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsv....syedstvnks.lvttrlnlsyegetrlithwlw

VSWPSKGVPDSAIGLLDVREQVEkwqrdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAE-GLVDVFQVVRGLRLQ
  ||   ||.|.  .| .  ..      .   | |.||| | ||.|| .|. . .. ...   | |. |.|  ||. 
kewpdwqvpessevmlkilrkir.....arstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvt

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 7-112 2.6e-21 70.8 In-house 77-182 (297) alignment
Range on Protein: 7-112
Range on HMM: 77-182/297.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSI----REYPDYILRELKIVDSrdaeGSSQHVKQFQYV
 .| .|||| .| ||||..|.|    .|||.|. .| |.  |  |||..  .     .. .  .     |.   || ||...        |..|.  |..
kyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqfl

SWPSKGVPDS
||| .|||  
swpdhGvpsd

subfamily_egg_pd Subfamily egg 7-186 4.8e-21 69.7 In-house 84-257 (307) alignment
Range on Protein: 7-186
Range on HMM: 84-257/307.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERgkAMCHKYWPDSGTQ----IYGFFEITLHSIREYPDYILR--ELKIVDSRDAEgssQHVKQFQ
 || .| || .| |||||||.. .   ||||.  .|     |. ||| . ..    . | ..|.   . . .| ..|  .||.| . | |   .... .|
efilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddee...rflehwq

YvSWPSKGVPDSAIGLLdvreqveKWQRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEG--LVDVFQVVRGLRLQRPGMVRSVM
.  .   .   | . .|       .  |.   ||.||..  |. ...| .|. . . .|         | . |  |||.|.  | ||.
g.dvnnssdvysplrvl.......rklrnl.skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvl

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 18-157 1.6e-20 68.3 In-house 40-173 (255) alignment
Range on Protein: 18-157
Range on HMM: 40-173/255.0
TTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLL
| | |....   |....|||..  | |.  |..|.|    .   . .... . .   | .|| |.|.         . || ..|  |. |  |. |  .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DVReqveKWQRDSgdKPIVVHCSGGCGRTGTYIAMCLLID
 .     |  |||  |..||||| | ||. ... . |.  
nil....kvvrds..ksvvvhCstGiGrsaafvlaelvyq

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 4-170 5.8e-20 66.2 In-house 80-247 (312) alignment
Range on Protein: 4-170
Range on HMM: 80-247/312.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDsgtqIYGFFEITLHSIR-EYP----------DYI-LRELKIVdsRDAEG
| . |..||||| .|.  ||...    |..|..|.   | |   | ||  |    | || ..  | .  ||           | |  | ||.|    | |
kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd....ivgfvdledhrvyteycteieiggkskdkithrvlkvv..vkatg

SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrDsgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQV
   .....|. ||| .|.|||    | .   | |   |   ||.. ||| | ||||| . .  .|  |.     .| ..
qesklnhyqwaswpdhgmpdscdtalrllsavkk...d..kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkds

subfamily_CG42327_pd Subfamily CG42327 6-119 1.1e-19 65.3 In-house 72-186 (319) alignment
Range on Protein: 6-119
Range on HMM: 72-186/319.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS----GTQIYGFFEITLHSIREYPDYILRELKIvDSRDAEgSSQHVKQFQY
  .||.| .| |.. ||||.||| .| .|| |..  | |  .| .|.| .    .|. || . .||        |..  | .    | |  |...  . |
nsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll.krvdke.esrelthywy

vSWPSKGVPDSAIGLLDV
  |.  .|| .   |. .
.kwleaevPaeeaaliam

subfamily_hpo-7_pd Subfamily hpo-7 16-155 2.5e-18 60.9 In-house 44-177 (263) alignment
Range on Protein: 16-155
Range on HMM: 44-177/263.0
PDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIG
 .| | |....   |....|||..  | |.  | .|.|    .   . .... . .   | .|. |...   .     . ||...|. |. |  |  |. 
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

LLDVReqveKWQRDSgdKPIVVHCSGGCGRTGTYIAMCLL
 | .     |  |.|  |..||||| | ||.  .  . |.
ilnil....kvarns..kslvvhcstGiGrsaafsvaElv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 92-184 1e-17 58.6 In-house 87-179 (440) alignment
Range on Protein: 92-184
Range on HMM: 87-179/440.0
SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
 |. .||..| .|| ||||  |  .| . ..|.. |  .|. |..|||| |.||||  ||.  .. . |    .|.| ..  .| .|| ||..
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqt

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 14-183 1.6e-17 57.9 In-house 99-272 (302) alignment
Range on Protein: 14-183
Range on HMM: 99-272/302.0
PLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQI--YGFFEITLHSIR----EY---PDYILRELKIVDSRDAEGSSQHVKQFQYVSW
|  .|.. .| .. .|. . .| |..  | ..  | .|. |   .   .| . ..  |..    |.    .. |  ..| ...  .   . |. ... .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PSKGVPDSAIGLLDVREQVEKWQRDsgdkpIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
| .| |. |   ||.    | ....     ..|||| | ||||| .|.   |.  . .   |. ..|  .|  | | |.
pdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavq

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1-56 7.1e-14 46.0 In-house 231-283 (440) alignment
Range on Protein: 1-56
Range on HMM: 231-283/440.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERgkaMCHKYWPDSG
|| |..|||||| ||  |  ||||.| .|. |||.|| .  ..    |  |||   
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvnt

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 8-57 8.9e-14 45.9 In-house 106-155 (350) alignment
Range on Protein: 8-57
Range on HMM: 106-155/350.0
FIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT
.||||.||| | |||.... . |   |..|... | .   |..||.. . 
YiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsy

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 6-185 1.4e-13 44.9 In-house 90-271 (302) alignment
Range on Protein: 6-185
Range on HMM: 90-271/302.0
KAFIATQGPLPDTT---DDFWRMVWEYKSSTIVMLANERERGKaMCHKYWP-DSGT-QIYGFFEITLHSIREYPDYI-LRELKIVDSRDAEGSSQHVKQF
.  | .| |  |..   ..|||||.. |  ..|.|. | |  |   ....|  ||. . || . .    . .  .      . ..    ..     |. .
rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvl

QYvsWPSKGVPDSAIGLLDVREQVeKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
..  |..| ||..   |    ..|   .  ..|...|.    |.|| |. ... . ...|...  . . ..|. .| ||| .| |.
tn..Wkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 7-182 1.5e-13 45.6 In-house 61-242 (290) alignment
Range on Protein: 7-182
Range on HMM: 61-242/290.0
AFIATQGPLPDT-------TDDFWRMVWEYKSSTIVMLANERERGKA----MCHKYWPDSGTQIYGFFEITLH--SIREYPDYILRELKIVDSRdaeGSS
..|.|| |. ..         .|| |. . |.  .||| .  |. .      | || |.|  ..  |  .|..  |  .  | . ||| .       .  
rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd...eee

QHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWqrdsgDKPIVVHCSGGCGRTGTYIAMCLLIDQLK-AEGLVDVFQVVRGLRLQRPGMV
  |.  ....| .  |... . ||.. ..|..      . |..|||  |  |  .  |. |    .   .| | . .|.  || ||  ..
ftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralai

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 135-182 1.5e-13 44.9 In-house 1-48 (69) alignment
Range on Protein: 135-182
Range on HMM: 1-48/69.0
IVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMV
.||||| | |||||.||. . . ..|.| |||.|  |. .|  || ||
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmv

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 136-182 4.1e-13 43.5 In-house 1-47 (69) alignment
Range on Protein: 136-182
Range on HMM: 1-47/69.0
VVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMV
||||| | |||||.||. . . ..|.| |||.|  |. .|  || ||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmv

0038934 (Phosphotyrosine protein) phosphatases II 100-178 4.9e-11 38.1 In-house 81-162 (194) alignment
Range on Protein: 100-178
Range on HMM: 81-162/194.0
QYVS--WPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLI-DQLKAEGLVDVFQVVRGLRLQR
.|..  .|..|.. |   ||.  . |... ... .. ..||| .| ||||| .|  |.   ...||  .. |. .|.  ...
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipn

subfamily_eak_pd Subfamily eak 8-110 6.9e-11 36.1 In-house 95-195 (332) alignment
Range on Protein: 8-110
Range on HMM: 95-195/332.0
FIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG--TQIYGFFEITLHSIREYPDYILRELKIVDSRDaegsSQHVKQFQYVSWP
.| |  .  |    ||.|| | || .||.|... | .     ||.|| .     .|.....  .  .   .  | |..    .    . .|. ...  | 
yiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGne....thrvlhykvfGwt

SKGVP
   .|
ettlp

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 7-109 1e-10 35.6 In-house 138-235 (244) alignment
Range on Protein: 7-109
Range on HMM: 138-235/244.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERgkamcHKYWPDSGTQIYGF--FEITLHSIREYPDYILRELKIvdSRDAEGSSQHVKQFQYVSW
 .| || || ||. |||.|. | .   .|.|    |       .|||||    .      .||    |. .    .|.|    | . | | .  ||   |
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnlei..esdmneshqaltmfqisnw

PSKGV
|| | 
psdgt

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 6-177 1.3e-10 35.4 In-house 83-254 (303) alignment
Range on Protein: 6-177
Range on HMM: 83-254/303.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSgtQIYGFFEITLHSIREYPDYILR---ELKIVDSRDAEGSSqHVKQFQYV
|  | || ||. |. |||.|. | |   ...|  . |  |   .  .|    | .  ||     . |.    |     ||..   . .  |  ..  .| 
kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn..qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyks.flhvhhyk

SWPSKGVPDS-AIGLLDVREQVEKWQRD-SGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGlvDVFQVVRGLRLQ
.|| . .|   .  ..    |..   |  |  .| |     ||||.||.  .      |..|     ...|. |   
awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseq..asldlvkclenv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 95-158 1.8e-10 35.1 In-house 216-288 (350) alignment
Range on Protein: 95-158
Range on HMM: 216-288/350.0
HVKQFQYVSWPSK---GVPDSAIGLLDVREQ------VEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQ
 | |.|.  |.       | | .  |.|...       |..  ..  .||.|||| |.|||||....  |. .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsd

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 6-109 6.2e-10 33.5 In-house 28-126 (130) alignment
Range on Protein: 6-109
Range on HMM: 28-126/130.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERgkamcHKYWPDSGTQIYGFFEITLH-SIREYPDYIlRELKIVDSRDAEGSSQHVKQFQYVSW
. .. || || ||. |||.|. |     .|.|    |       .|||||    .   .|..  . |.  ..| .  ..  ..|   | | .  ||   |
aeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkni.kasnleiesdlneshqaltmfqisnw

PSKGV
|| | 
psdgt

PTEN_1 98-161 7.7e-10 33.9 In-house 94-160 (196) alignment
Range on Protein: 98-161
Range on HMM: 94-160/196.0
QFQ--YVSWPSKGVPDSAIgLLDVREQVEKW-QRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQ-LKA
...   ....  |.|. .  |.|. .... | ..|.  . ..||| .| ||.|| .|..|.  . | |
gveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgklta

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 6-55 3.7e-09 30.4 In-house 107-156 (349) alignment
Range on Protein: 6-55
Range on HMM: 107-156/349.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS
| .|||| ||| | |||....   .   .. | .. | .   |..|| . 
kkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel

subfamily_CG42327_pd Subfamily CG42327 131-182 6e-09 30.0 In-house 246-298 (319) alignment
Range on Protein: 131-182
Range on HMM: 246-298/319.0
GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAE-GLVDVFQVVRGLRLQRPGMV
   |.||||| | ||||. ||  . | .|.     ||. |.|  .| .|   |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasav

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 95-158 1.3e-08 28.6 In-house 219-291 (349) alignment
Range on Protein: 95-158
Range on HMM: 219-291/349.0
HVKQFQYVSWPSKGV---PDSAIGLLDVREQV------EKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQ
 . |.|.  |.  ..   | | .  |.|....      ...  ..   ...|||| ||||||... . ||.. 
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsi

subfamily_PTEN_pd Subfamily PTEN 116-164 6.7e-08 27.7 In-house 98-145 (184) alignment
Range on Protein: 116-164
Range on HMM: 98-145/184.0
LLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAmCLLIDQLKAEGL
| .. |..|||   . .. .||||  | ||||. |. ..|. .|. |  
leeivediekwleedkknvvvvHCkaGkGRtGvliv.ayllksllleka

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 121-184 6.9e-08 26.7 In-house 216-280 (297) alignment
Range on Protein: 121-184
Range on HMM: 216-280/297.0
EQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
 |.|  . .   . ...|||| | ||.|  .    ....|. . . ||  ... || ||. .|..
lqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqt

subfamily_DSP11_pd Subfamily DSP11 98-182 3.4e-07 24.3 In-house 81-167 (178) alignment
Range on Protein: 98-182
Range on HMM: 81-167/178.0
QFQYVSWPSKGVPDSAIgLLDVREQVEKWQ--RDSGDKPIVVHCSGGCGRTGTYIAMcLLID--QLKAEGLVDVFQVVRGLRLQRPGMV
... .  | . ||.. . . .  |.|...   ..  || | |||  |  |||  |    |||  ....|  ...|. .||  |.|   .
kylklncpGhevpkeel.vkkfkeavkefleknkdndkligvhCthGvnrtGyliCr.ylidvegyepedaieafeearGhslerenyl

subfamily_CDC14_pd Subfamily CDC14 133-183 3.5e-07 24.4 In-house 264-309 (328) alignment
Range on Protein: 133-183
Range on HMM: 264-309/328.0
KPIVVHCSGGCGRTGTYIAmCLLIDQLKaeglVDVFQVVRGLRLQRPGMVR
  |.|||  | ||||| || | |. . .    .   ...  ||. |||.| 
GaiavhCkaGLGrtGtLia.cylmkhyr....ftaaeaiawlricrPGsvi

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 5-38 1.2e-06 22.3 In-house 84-117 (347) alignment
Range on Protein: 5-38
Range on HMM: 84-117/347.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLA
.| .| || |||||  |||.||   | . .| . 
skeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

subfamily_VSP_pd Subfamily VSP 115-158 1.3e-06 22.5 In-house 111-154 (212) alignment
Range on Protein: 115-158
Range on HMM: 111-154/212.0
GLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQ
 || . ..|..|  .  .. ...|| || ||||| .   ||  .
ellvftkevkewlekdlknvlaihckGGkgrtGtivcalllase

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1-51 2.6e-06 21.2 In-house 70-121 (332) alignment
Range on Protein: 1-51
Range on HMM: 70-121/332.0
GYCKRKAFIATQGPLPDTTDD-FWRMVWEYKSSTIVMLANERERGKAMCHKY
|| |. |.| .| |. | |.  ||||| | | | |... .  |. |  .   
gyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapyd

0048567 (Phosphotyrosine protein) phosphatases II 66-160 3.4e-06 21.5 In-house 52-105 (157) alignment
Range on Protein: 66-160
Range on HMM: 52-105/157.0
TLHSIREYPDYILRELKivdsrdaegssqhvkqfqyvswpskgvpdsaiglldvreqvekwQRDSGDKPIVVHCSGGC---GRTGTYIAMCLLIDQLK
.|. . ..  .. . ||                                            . .  .|.|.|||. |    |||.| |.  |.. . .
nlailyrFilklnkflk............................................ilelagkaiavhckaglkkrgrtatLigcYlilhlgf

subfamily_DSP23_pd Subfamily DSP23 132-184 5.6e-06 21.1 In-house 84-131 (148) alignment
Range on Protein: 132-184
Range on HMM: 84-131/148.0
DKPIVVHCSGGCGRTGTYIAmCLLIdqlKAEGLVdVFQVVRGLRLQRPGMVRS
.. . |||  | ||||| .| | |.   | ..|    . .  .| .||| | .
neavsvhcllgrgrtgtmla.cylv...kerkla.aaeaiaevrrlrpgsvet

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 92-185 6e-06 19.1 In-house 203-295 (346) alignment
Range on Protein: 92-185
Range on HMM: 203-295/346.0
SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEK--WQRDSGdkpIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
 |  ..  ..  |     |  .. .. .  |       .. |   . |    ||||. ..|     |.||      ....... .. |||| | | 
dsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnag...vcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesf

subfamily_Tensin_pd Subfamily Tensin 97-152 6.8e-06 18.7 In-house 70-124 (189) alignment
Range on Protein: 97-152
Range on HMM: 70-124/189.0
KQFQYVSWPSKGVPdSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAM
|. . . ||..  | |   |  . .....| .   .. .|||| || ||.|  .. 
kkvldfGWPdllaP.sleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsa