Gene PTPRD-77 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP136_AA protein Get Run
AqueP136_AA_0-186 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1-183 3.1e-78 258.8 In-house 86-265 (564) alignment 
Range on Protein: 1-183
Range on HMM: 86-265/564.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIvdSRDAEGSSQHVKQFQ
|| ||||.|||||||..|..||||||||..||||||| . .|.||  ||||||..||. || ...||..  |. ||..|..|.  ..  . .|. |.||.
gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl..kkkkssesreVrqFh

YVSWPSKGVPDSAIGLLDVREQVEKWQrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
..|||..|||.|| .|||....|....  .. .||||||| | |||||.|..  .....|.|..||..|.|. || ||. || 
FtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-183 1e-74 246.5 In-house 84-264 (318) alignment 
Range on Protein: 1-183
Range on HMM: 84-264/318.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDsrDAEGSSQHVKQFQ
|| ..||.||.|.|||.| .|||||||| .|..||||..|.||||| .|.|||..|.. ||   ..|..  |. ||.|||.|.    . | .|..|.|..
GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyh

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
| ||| .|||.|. .|||.  ||.|.|..|| .|||||||.| ||||..||.  |....|||.||||||.|. || ||. ||.
ytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvq
0050432 (Phosphotyrosine protein) phosphatases II 2-185 2.6e-70 232.5 In-house 102-285 (308) alignment 
Range on Protein: 2-185
Range on HMM: 102-285/308.0
Y--CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS---GTQIYGFFEITLHSIREYPDYILRELKIVDSRDAegSSQHV
|   ....|||||||||.|..||||||||.....|||| .. |.|.  |..|||..   |...|| | .|| |. ...||..|.|......|    | .|
yssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtv

KQFQYVSWPSKGVPDSAIGLLDVREQVEKWQrdsGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
..|.| .||  |||.|.  |||  |.|.|..   ...||||||| |.|||||.||. ||..||..|| ||||..|. || |||||| ..
thfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-184 8.3e-70 230.4 In-house 95-275 (298) alignment 
Range on Protein: 2-184
Range on HMM: 95-275/298.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAegSSQHVKQFQY
| .|.||||||.||. |. ||||||.|....||||| | .| .|  .||||||.|.. || ....|.|  |. |.| |.||. ... .  ....|.|...
ykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhf

VSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
.|||.||||  |  .||....|...|...|.||..|.|| | ||.||.||.  .....|.|  |||||||. || .|||.|..
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqt
0051299 (Phosphotyrosine protein) phosphatases II 1-185 9.6e-70 230.6 In-house 87-272 (288) alignment 
Range on Protein: 1-185
Range on HMM: 87-272/288.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDS--RDAEGSSQHVKQ
|| . ..|||||||||.|..||||||||.....|||| .. |.|.  |..|||..|...|| . .|| |. ...||..|.|....    | .| |..|..
gynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvth

FQYVSWPSKGVPDSAIGLLDVREQVEKWQRdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|.| .||  |||||.  |||  ..| |... ||..|.||||| |.|||||.||. ||..||..|| |||...|. || |||||| ..
fhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0046845 (Phosphotyrosine protein) phosphatases II 3-185 5.7e-67 221.4 In-house 74-260 (284) alignment 
Range on Protein: 3-185
Range on HMM: 74-260/284.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG-TQIYGFFEITLHSIREYPDYILRELKIVDSrDAEGSSQHVKQFQY
 ..|.|||||||||.|..||||||||.....|||| .. |.|. .|..|||..| ...|| | .|| |. ...||..|.|....  . .| | .|..|.|
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhy

VSWPSKGVPDSAIGLLDVREQVEKWQRD-SGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEG---LVDVFQVVRGLRLQRPGMVRSV
 |||  |||.|.  ||.  ..|...... .|..|||||||.|.|||||.||. ||..||..||    |||...|. || |||||| ..
tswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-183 6.5e-67 220.8 In-house 86-267 (319) alignment 
Range on Protein: 1-183
Range on HMM: 86-267/319.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIvDSRDAEGSSQHVKQFQ
|| .|..|||||.|| .|..||||||||..||..|||..  |..|  ..||||.   . || . .|| . .|  ||| |.||. . . .|  . .||.||
gyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfq

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
| .|| ..||..| .|||. ....| .. . ..||||||| | |||||.|..   ....| ||..|||..|. ||.||. ||.
yteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-184 9.6e-67 220.3 In-house 84-268 (305) alignment 
Range on Protein: 1-184
Range on HMM: 84-268/305.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQ--IYGFFEITLHSIREYPDYILRELKIVDSRDaEGSSQHVKQ
|| ..|..|..||||..| .||||...|.| ||||||.. .| ||  |..|||.| |.   .| |...|.| ....||| |.|||   .. .  |. | |
gykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlq

FQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
.|  .|| .|||..|  ||.. ..|.| |. . ..|..|||| | ||||..||. . ...||.|. ||||.|.. || .|..|| .
yqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqt
0040438 (Phosphotyrosine protein) phosphatases II 2-186 2.8e-66 219.3 In-house 82-263 (317) alignment 
Range on Protein: 2-186
Range on HMM: 82-263/317.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSrdAEGSSQHVKQFQY
. ....|||||||||.|..||||||||.....|||| .. |.|. .|..|||. .|. || | .|| |. |.....||.|...|.   .. | .|..|.|
pnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhy

VSWPSKGVPDSAIGLLDVREQVEKWQRdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSVM
 .||  |||.|   |||  |.|..... ....|..||||.|.|||||.||. |...||. || |||...|. || ||||.| . .
tgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpe
0047943 (Phosphotyrosine protein) phosphatases II 2-185 9.2e-66 217.4 In-house 73-258 (273) alignment 
Range on Protein: 2-185
Range on HMM: 73-258/273.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG---TQIYGFFEITLHSIREYPDYILRELKIVDSRDAEgsSQHVKQ
| . ..|||||||||.|..||||||||.....|||| .. |.|.  |..|||..|   ...|| | .|| |. ...||..|.|..... . |  | .|..
ynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvth

FQYVSWPSKGVPDSAIGLLDVREQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|.| .||  |||.|   ||.  |.|.|... . ...|.|||||.|.|||||.||. ||.|||..|| |||...|. || |||||| ..
fhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2-184 2.4e-65 215.2 In-house 48-227 (250) alignment 
Range on Protein: 2-184
Range on HMM: 48-227/250.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAmCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIvdSRDAEGSSQHVKQFQY
| .|||||||||||..|. ||||||.|.||.|||||.| .| .|  .|.|||  ....||   ..|.|  |. ||. |.||.  |.  . ....|.|...
yderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllskeefadytkrklkl..skakkaderivrqlhf

VSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
|.|| ||||. |   |.....|.. |. .|..|..|.|| | ||.|..||.  ....|| |  ||||.|.. || .||..|.|
vvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphaves
0039614 (Phosphotyrosine protein) phosphatases II 5-185 2.4e-65 216.2 In-house 100-275 (297) alignment 
Range on Protein: 5-185
Range on HMM: 100-275/297.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKaMCHKYWPDSGTqIYGFFEITLHSIREYPDYILRELKIVDsrdaEGSSQHVKQFQYVSW
 ..|||||||||.|..||||||||.....|||| .. |.|. .|..|||..|.  || | .|| .. ....|..|.|....    .| | .|..|||..|
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgw

PSKGVPDSAIGLLDVREQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|  |||.|.  ||.. |.|..... . ...|..||||.|.|||||.||. |...||. || |||...|. || ||||.| . 
pdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp
0036941 (Phosphotyrosine protein) phosphatases II 4-186 7e-65 214.6 In-house 76-264 (297) alignment 
Range on Protein: 4-186
Range on HMM: 76-264/297.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS--GTQIYGFFEITLHSIRE--YPDYILRELKIVDSrdAEGSSQHVKQF
  ..|||||||||.|..||||||||.....|||| .. |.|. .|..|||.   ... || | .|| |. .  ..||.||.|...|    .| | .|..|
lkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthf

QYVSWPSKGVPDSAIGLLDVREQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLK---AEGLVDVFQVVRGLRLQRPGMVRSVM
.| .||  |||.|.  |||  |.|.|... . ...|..||||.|.||.||.||. |...||.    || ||....|. || ||||.| ...
hytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle
0045450 (Phosphotyrosine protein) phosphatases II 1-185 1.4e-64 214.1 In-house 102-290 (307) alignment 
Range on Protein: 1-185
Range on HMM: 102-290/307.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQ-IYGFFEITLHSIREYPDYILRELKIVDSrDAEGSSQHVKQF
|| . ..|||||||||.| .|||||.||.....|||| .. |.|. .|..||||.|..  || | .|| |. ....|..| |.. |. | .| | .|..|
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthf

QYVSWPSKGVPDSAIGLLDVREQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGL---VDVFQVVRGLRLQRPGMVRSV
.| .||  |||.|   |||  |.|.|..... ...|..||||.|.|||||.||. |...||..||    ||....|. || ||||.| . 
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp
subfamily_PTPRA_pd Subfamily PTPRA 1-186 2e-64 212.6 In-house 96-282 (330) alignment 
Range on Protein: 1-186
Range on HMM: 96-282/330.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAE--GSSQHVKQ
|| ... |||.|||. .| .|||||.||.||.|||||.. .|| .  |..|||| |.  ||   ....   .  || .|.. . .  ||    .|. |.|
GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrq

FQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDkPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSVM
| . |||  |||  .||.|.. ..|.| .. |.. ||||||| | |||||.|..  .....|||..||||..|. |||||| ||.. .
fhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtde
subfamily_PTPRB_pd Subfamily PTPRB 1-184 7.8e-64 210.5 In-house 89-270 (293) alignment 
Range on Protein: 1-184
Range on HMM: 89-270/293.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS-GTQIYGFFEITLHSIREYPDYILRELKIVDsrdaEGSSQHVKQF
||  .. |||||||||.|.||||||||| |||.|||| .  |.||  |..|||.   ...||  ..|| . .|. |...|||||      | ....|.|.
gynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqy

QYVSWPSKGVPDSAIGLLDVREQVEKWQ-RDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
...|||  |||...  |||  ..|.... ... ..||||||| | |||||.||.  |..... | .||.| .|  || .|  .| .
hftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqt
0043336 (Phosphotyrosine protein) phosphatases II 3-185 1.3e-63 210.4 In-house 85-263 (278) alignment 
Range on Protein: 3-185
Range on HMM: 85-263/278.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPdSGTQIYGFFEITLHSIREYPDYILRELKIVDsrDAEGSSQHVKQFQYV
 . ..|||||||||.|..||||||||....||||| .. |.|.  |..||| .|.. || | .|| .. ...||..| |....    .| |..| ...|.
nvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhyl

SWPSKGVPDSAIGLLDVREQVEKWQRdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.||  |||.|   |||  ..| .... . ..|..||||.|.|||||.||. ||..||. || ||....|. || ||||.| . 
gwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp
0040439 (Phosphotyrosine protein) phosphatases II 3-185 7.5e-62 204.5 In-house 51-232 (249) alignment 
Range on Protein: 3-185
Range on HMM: 51-232/249.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSrdAEGSSQHVKQFQYV
   ..|||||||||.|..|||||.||.....|||| .. |.|.  |..|||..|.. || | .|| |. ...||..|.|.....   .|.| .|...||.
yikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqyt

SWPSKGVPDSAIGLLDVREQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.||  |||.|   |||  |.|.|....   ..|..||||.|.|||||.||. |...||. |. ||....|. || ||||.| . 
dwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp
DSPc_SM00195 4-185 1.2e-61 203.7 In-house 67-248 (263) alignment 
Range on Protein: 4-185
Range on HMM: 67-248/263.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS--GTQIYGFFEITLHSIREYP-DYILRELKIVDSRDaeGSSQHVKQFQ
|.|..||||||||.| .|||||||| |...|||| .| |.||  |..|||..  |.. .| ....| .  ... ..|||.|..    .    .. |.|.|
kkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyq

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
| .|| .|||||.  .|.. ..|.|... | ..||||||| |.|||||.... .....|..|  ||.|..|. || ||||||.. 
yknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
PTPc_SM00194 4-185 1.2e-61 203.7 In-house 67-248 (263) alignment 
Range on Protein: 4-185
Range on HMM: 67-248/263.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS--GTQIYGFFEITLHSIREYP-DYILRELKIVDSRDaeGSSQHVKQFQ
|.|..||||||||.| .|||||||| |...|||| .| |.||  |..|||..  |.. .| ....| .  ... ..|||.|..    .    .. |.|.|
kkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyq

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
| .|| .|||||.  .|.. ..|.|... | ..||||||| |.|||||.... .....|..|  ||.|..|. || ||||||.. 
yknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
0042113 (Phosphotyrosine protein) phosphatases II 3-185 1.6e-61 203.2 In-house 49-229 (245) alignment 
Range on Protein: 3-185
Range on HMM: 49-229/245.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDsrDAEGSSQHVKQFQYV
   . |||||||||.|..|||||.||....||||| .| |.|.  |..|||..... || | .|| |.  ..||..|.|....  . .. |..| ...|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtn..lgddesrevihyhyl

SWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.||  ||||.   |||. | |.|........|..||||.|.|||||.||. |...||..|. |.....|. || ||||.| . 
pwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtp
0045098 (Phosphotyrosine protein) phosphatases II 2-185 2.6e-61 202.8 In-house 62-258 (278) alignment 
Range on Protein: 2-185
Range on HMM: 62-258/278.0
YckRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDS--RDAEGSSQHVKQF
|  .|.|||||||||.|..|||||.||.....||||... |.|.  |..|||..|...|| |..|| |. ...||.|| |....   ..... | .|...
y..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthl

QYVSWPSKGVPDSA--IGLLDVREQVEKWQR------------DSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLkaEGLVDVFQVVRGLRLQRPG-MVRS
.|..||  |||..     .|.. |.......            .....|..|||| |.|||||..|. |....|  || ||....|. || |||| .| .
hylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqn

V
 
l
subfamily_PTPRK_pd Subfamily PTPRK 1-183 5.9e-61 201.0 In-house 81-261 (314) alignment 
Range on Protein: 1-183
Range on HMM: 81-261/314.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQiYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQ
.| . .|||.|||||..|. ||||.|.......||||..  | |.  | ||||. ... || ....| .     ... | ...  .  .    . |.|||
sykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfq

YVSWPSKGVPDSAIGLLDVREQVEKWQRDsGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
...||. .|| || |||..  .|.|.| . .. .|||||| |.|||||.||.. ..| .. ||.||||..|. || ... || 
flgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmve
Y_phosphatase Protein-tyrosine phosphatase 4-185 7.5e-61 200.9 Pfam-A 40-223 (235) alignment 
Range on Protein: 4-185
Range on HMM: 40-223/235.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWP--DSGTQIYGFFEITLH-SIR-EYPDYILRELKIVDSRDAEgSSQHVKQF
. |.||||||||..| .|||||||..|...||||... |.|.  |..|||  ..... || ....|  ..  .  .|.||.|.. .. . .  ...|||.
ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkql

QYVSWPSKGVPDSAIGLLDVREQVEKWQrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.| .|| .|||.|. .|||. ..|||.. .. ..|.||||| |.|||||..|. .|..||.||. |||.|.|. || |||||| |.
hytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
Y_phosphatase Protein-tyrosine phosphatase 4-185 7.5e-61 200.9 In-house 40-223 (235) alignment 
Range on Protein: 4-185
Range on HMM: 40-223/235.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWP--DSGTQIYGFFEITLH-SIR-EYPDYILRELKIVDSRDAEgSSQHVKQF
. |.||||||||..| .|||||||..|...||||... |.|.  |..|||  ..... || ....|  ..  .  .|.||.|.. .. . .  ...|||.
ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkql

QYVSWPSKGVPDSAIGLLDVREQVEKWQrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.| .|| .|||.|. .|||. ..|||.. .. ..|.||||| |.|||||..|. .|..||.||. |||.|.|. || |||||| |.
hytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-184 6.1e-60 197.7 In-house 87-264 (288) alignment 
Range on Protein: 3-184
Range on HMM: 87-264/288.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT-QIYGFFEITLHSIREYPDYILRELKIVdsrdAEGSSQHVKQFQY
 |.|..|||||||.|| .|||..|.|.|.||||||..  |.||  |..||||... . || ...|| . .|  |..||.| ..     ...  ...|.||
kkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqy

VSWPSKGVPDSAIGLLDVREQVEKWQRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
 .|| .|||.|.  ||....||.  . .   .||.|||| | |||||.||.  |||....|  .||. .|  || ||. .|  
laWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-185 8.8e-60 197.0 In-house 86-269 (290) alignment 
Range on Protein: 1-185
Range on HMM: 86-269/290.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAeGSSQHVKQFQ
|| ..|..||||||...|  |||...|. |.. |||| |. | ||  |..|||||.|. || |.|.|.. ... .|| |.|.. ... | |..|.|.|.|
gykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyq

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
  .|.|.|      . | | |...| || .|...||||||.. ||.....|.   |.. | || .|||||.. .| |.||.| .|
itnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-185 4.2e-58 192.1 In-house 99-277 (319) alignment 
Range on Protein: 1-185
Range on HMM: 99-277/319.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLAnerergKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEgSSQHVKQFQ
|| ... .||.||||..| .|||||.|||..||||.|.      | .| .|||  . . .. |.. ..|. |  .|..|.... .    .   ....|| 
GyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkek.dirkitqfh

YVSWPSKGVPDSAIGLLDVREQVEK-WQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.  || .||||... |. . ..|..  ..  . ..|||||| |.||||.||..  |.|..| |  |||...||.|| ||. .|...
flGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-185 4.5e-58 191.6 In-house 80-262 (281) alignment 
Range on Protein: 2-185
Range on HMM: 80-262/281.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG-TQIYGFFEITLHSIREYPDYILRELKIvdsRDAEGSSQHVKQFQ
| . |..||||||.|.. ..||.||||.| |.|||...| | ||  ||.||||   . .|| . .. .. .| . || |..|.   .  .| ...|.|..
ykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl...eresgetreveqla

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAE-GLVDVFQVVRGLRLQRPGMVRSV
|..|| .|||...  ||. |..|.| .. . . |.|.||| | ||||||||.  |.....||   .|| .||. || .|  ||..|
ytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv
subfamily_Ptp69D_pd Subfamily Ptp69D 1-184 6.7e-58 191.2 In-house 86-271 (307) alignment 
Range on Protein: 1-184
Range on HMM: 86-271/307.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDA---EGSSQHVK
|| ..| ||| |.|.  | .|||||..| .. .||||.|. |  .. |.||||.  .. ||   ..| | .. .||| |||..    .    .  |..| 
gykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvv

QFQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
|..| .|.   ||..| |||.. |||.. .. .   ||||||| | ||.|...|...|..|||||  ||.|..|..|| ||. .|.|
qyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-185 1.8e-57 190.0 In-house 63-241 (284) alignment 
Range on Protein: 1-185
Range on HMM: 63-241/284.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLAnerergKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEgSSQHVKQFQ
|| ... .|||||||..| .|||||.|||..||||.|.      | .| .|||  . . .. |.. ..|. |  .|..|.... .    .   ....|| 
GyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkek.dirkirqfh

YVSWPSKGVPDSAIGLLDVREQVEK-WQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
.  || .||||... |. . ..|..  ..  . ..|||||| |.||||.||..  |.|..| |  |||...||.|| ||. .|...
flgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl
0037934 (Phosphotyrosine protein) phosphatases II 7-184 1.3e-56 187.2 In-house 45-227 (243) alignment 
Range on Protein: 7-184
Range on HMM: 45-227/243.0
AFIATQGPLPDTTDD----FWRMVWEYKSSTIVMLANERERGKAMCHKYWPdsGTQIYGFFEITLHSIREYPDYILRELKIVDsRDAEGSSQHVKQFQYV
 .||||||||.|..|    ||||.||.....|||| .. |.|.  |..|||  |.. || |..|| |.....||..|.|...   |... ...| ...|.
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygdftvtllseehlddytvrtlllen.ldlddltrlvihyhyl

SWPSKGVPDSAIGLLDVREQVEKWQRD-------SGDKPIVVHCSGGCGRTGTYIAMCLLIDQLkaeGlVDVFQVVRGLRLQRPG-MVRS
.||  |||||   |||  ..| .....       ....|..||||.|.|||||.||. |....|   | ||....|. || |||| .| .
pwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-185 3.6e-56 185.3 In-house 81-264 (287) alignment 
Range on Protein: 1-185
Range on HMM: 81-264/287.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRdAEGSSQHVKQFQ
|| ..||||....|. .|  .||..... . ..||||..|.|  . .|..|||.. . ..| ..|.| .   . .|| |.|..  .   .|. |.|||.|
gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn.kagdkqqvkqyq

YVSWPSKG-VPDSAIGLLDVREqVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
. .|.|.| |.. .  || . |   | || .|. .|||||| . ||.....|.   |.. | || .|||||..  | |.||.|. |
itnWdstgkvtepqtillviee.myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-185 5.8e-56 184.7 In-house 87-265 (315) alignment 
Range on Protein: 1-185
Range on HMM: 87-265/315.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSgTQIYGFFEITLHSIREYPDYILRELkivdSRDAEGSSQHVKQFQ
|| |.. .||.|||.. . .||||.|.|.. ..||||.|  |. | .. |||||    ||| . .|. |   . .|  | |    |   .   ..| |..
Gynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl....svvfgdnirevvqlh

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGdKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
| |||  ||| ..| |...  .| ... .|   .|||||| | |||||.|..  ..||..|| ..||.....|.| .| .||...
ytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqva
subfamily_PTPRG_pd Subfamily PTPRG 1-183 8.5e-56 184.3 In-house 86-271 (563) alignment 
Range on Protein: 1-183
Range on HMM: 86-271/563.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEG----SSQHV
|| | ||||||||||.||.||||||.|| ....|||..|  |||.  |. |||  ... || ...|| .      |  |.|.| . .  ..    . ..|
GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklv

KQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRD-SGdkPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
.|..| .|| .|||....  |   .. .. ...  |  ||||||| | |||||||..  |. |...|  |.||.... .|.||. .| 
rqyhytkWPdhgvPehslpvLifvkkssaankaeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvq
subfamily_PTPN12_pd Subfamily PTPN12 4-183 8.1e-55 180.7 In-house 81-261 (290) alignment 
Range on Protein: 4-183
Range on HMM: 81-261/290.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS-GTQI-YGFFEITLHSIREYP-DYILRELKIVDSrdaeGSSQHVKQFQ
.....||.|||||.| ||||||.||.. . .||. .| | ||  |..|||.. .... .| ||.||.. .    |...| ||.  .    . |..|.||.
gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfh

YVSWPSKGVPDSAIGLLDVREQVEKWQRdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGL---VDVFQVVRGLRLQRPGMVR
| .|| .||| ||  ||.. |.|.. |. | |.|.||||| |.||||| ||. .  ..|||| .   .|||..|. || ||. .|.
YtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvq
subfamily_PTPN6_pd Subfamily PTPN6 5-183 5.7e-54 178.2 In-house 97-281 (306) alignment 
Range on Protein: 5-183
Range on HMM: 97-281/306.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQ-IYGFFEITLHSIREYPDYILRELKIVDsRDAEGSSQHVKQFQYVS
.|..||||| |..|  |||||||. .|  |||. .| |||| .| .||||. ..  ||  ..|  | ..  |||||||..   .. ......| |... |
dksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvsk.kkkkkeerevfqyhfks

WPSKGVPDSAIGLLDVREQVEKWQRDSG---DKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGL---VDVFQVVRGLRLQRPGMVR
|| .||| .   .||  |.|.. |...      ||||||| | |||||.| . .|..... .||   .|. ..|. .| || |.|.
WPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4-183 3e-53 175.7 In-house 71-252 (274) alignment 
Range on Protein: 4-183
Range on HMM: 71-252/274.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQ----IYGFFEITLHSIREYPDYILRELKIVDSRDaegsSQHVKQF
. ||..||||||| | .|||||... ... ||||.. .|. .. |..|.||.        || .||. ..| |  || .|.| .  . .    ...|| .
eskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler....ersvkhy

QYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDK--PIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
 | .|| . .||.|  |||. ..||. ....  |  |.||||| | |||| .||. . . ||..|. |||...|  |||.| |||.
wytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvq
subfamily_PTPN3_pd Subfamily PTPN3 6-184 1.3e-52 173.4 In-house 84-260 (280) alignment 
Range on Protein: 6-184
Range on HMM: 84-260/280.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT-QIYGFFEITLHSIREYPDYILRELKIVDSRDAEgsSQHVKQFQYVSW
. .|||||||..|. |||.|||| |||.||||..  |||.  ||.|||...  . || |...... .|   |.|||| . |..  |  .... |.||..|
nryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketke..erkilqlqylaW

PSKGVPDSAIGLLDVREQVEKwQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
| .||||..  .|.. |.|.| .| . ..|.|||||.| |||| .|.. . .  . |.  | . ..|| .| ||  .|..
pdhgvPddsadflefvervrk.lrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqt
subfamily_PTPN9_pd Subfamily PTPN9 1-181 1.9e-51 169.9 In-house 80-272 (297) alignment 
Range on Protein: 1-181
Range on HMM: 80-272/297.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPD--SGTQIYGFFEITLHSIREYPDYILRELKIVDSRDaeGSSQHVKQ
|| ..||||||||||. |..|||||||| .  .||| .   |||.  | .|||.    .. .|.....  ...|. ||  | |.| ....  . |..|  
GykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt..eesrkvth

FQYVSWPSKGVPDSAIGLLDVREQVEK------------WQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGM
||..|||  |||.||  ||||.|.| .            |. .  . ||||||| | |||||.|.. . ...|. .| |||...|. || ||  .
fqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1-183 3e-51 168.9 In-house 80-277 (301) alignment 
Range on Protein: 1-183
Range on HMM: 80-277/301.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGF--FEITLHSIREYPDYILRELK--IVDSRD--------
|| ..|.|||.|||.  |  ||||..|..| ..|||..|..|. |. |..|||.| .. . |  |..||..   |||...|.|.  | |. .        
gysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkf

---AEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
   .. ||..| |.| ..||  ||       | | ..| . |.  |  |.||||| . .|.|.|... . ..| |||| ||||||.. .| ..||.| 
kvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVt
subfamily_PTPN13_pd Subfamily PTPN13 7-183 8e-51 167.9 In-house 78-253 (273) alignment 
Range on Protein: 7-183
Range on HMM: 78-253/273.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG---TQIYGFFEITLHSIREYPDYILRELKIVDSRdaEGSSQHVKQFQYVS
 .||.|||||.|..|||.|||| |.. |.|...|.|.||  ||.|||.|    ..... .|..|  . .. .. .|.|.. ||.   | |..| ....|.
eyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdse..sgesrevahlnfvk

WPSKGVPDSAIGLLDVREQVEKWQRDSGdkPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
||  ||| ||  || .  .| . |.|.|  ||||||| | ||.||.|..  ... .. .  .|| ..|| || || |.|.
wPdhgvPssaaellqfvaevrrlqtdag..PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-185 1.4e-48 160.7 In-house 88-274 (325) alignment 
Range on Protein: 3-185
Range on HMM: 88-274/325.0
CKRKAFIATQGPLPDTTDDFWRMVWEYKsSTIVMLANERERGKAMCHKYWPDS--GTQIYGFFEITLHSIREYPDYILRELKIVDSRdaEGSSQHVKQFQ
 |.. |.|.| ||..|..|.||.| ... ...|.. || . ||  | .|||.    .. .| .|. | .| |. ||. | |.. . .  .| .. |||||
kkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk..kGetrsvkqfq

YVSWPSKGVPDSA---IGLLDVREQVEKWQRD--SGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
. ||.  ||.      | .|.. ..|..  .    .  ||.|||| | ||||..|..  .....  |  ||.|..|. || .|| ||..|
lqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 5-183 1.5e-48 160.5 In-house 91-268 (297) alignment 
Range on Protein: 5-183
Range on HMM: 91-268/297.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKaMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIvdSRDAEGSSQHVKQFQYVSW
.. .|.|| | ..| .|||.||.... ||||||... || |  | .||.|.|.. .|   ..|.|. |   .| |||..  ....  . . |||.|.|.|
khrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelev..tkgkakarrvvkqyqfveW

PSKGVPD--SAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
|.| |.   ||  ||.. ..|.|   .  . |..|||. | |||| ....   . . | |  ||.|..|. || .|| .|.
PdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvq
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 4-184 5.3e-48 158.3 In-house 73-251 (283) alignment 
Range on Protein: 4-184
Range on HMM: 73-251/283.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQhVKQFQYVS
. | .|..|.|| .|  |||.||.. | ..||||.. .|  .  | .|||  |.. || | .||.       .| .|| .  .  |. .   .  .|.. 
qdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvid

WPSKGvPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
| . | ... |  |   ..|   |..| . ||||||| | |||...||.   ......| .||||.||. .| ||...|..
Wleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 5-183 2.1e-47 156.4 In-house 85-260 (515) alignment 
Range on Protein: 5-183
Range on HMM: 85-260/515.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPD--SGTQIYGFFEITLHSIREYPDYILRELKIVDSRDaegsSQHVKQFQYV
 ||.||.|||.. ..|||||.|.... .||.|... .|  |  | |||||  . .  .| ... | |.    . | |.|... . |    |. | ||.. 
dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd....srtvtqfhft

SWPSKGVPDSAIGLLDVREQVeKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
 || ||||  .  || .  .| | ...    |...||| | |||| .|..   . . |    ||||..|. .| .|| .|.
eWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvq
subfamily_PTPN23_pd Subfamily PTPN23 7-185 2.9e-47 155.9 In-house 84-266 (288) alignment 
Range on Protein: 7-185
Range on HMM: 84-266/288.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS--GTQIYGFFEITLHSIREYPDYILRELKIVDSRdAEgSSQHVKQFQYVSW
 |||||.||. |  |||.||.| |||.|||| .. |.||  ...||| .   |. .| ...||.| || . .. |.||.   . |.   ..|.  |. ||
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld.ad.avksvshlqltsW

PSKGVPDSAIGLLDVREQVEK---WQRDSGDKPIVVHCSGGCGRTGTYIAM-CLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|. |||.|   ||.. ..||.    ..   ..|.||||| | ||||..  . . ...  | .||.|. |||. || ||  ||. .
pelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqek
subfamily_PTPRN_pd Subfamily PTPRN 5-184 4.2e-47 155.3 In-house 99-277 (297) alignment 
Range on Protein: 5-184
Range on HMM: 99-277/297.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREY-PDYILRELKIVDSRDAEgsSQHVKQFQYVS
. |.|||||||..|  |||.||||  .  ||.|.. .| |   |..|||| |...|...|. | |   .  ||..| . . . .  |  .. | || ..|
apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse..trtvtqfhfls

WPSKGVPDSAIGLLDVREQVEKWQRDsGDKPIVVHCSGGCGRTGTYIAMCLLIDQL-KAEGLVDVFQVVRGLRLQRPGMVRS
||..||| ||  ||. | .|.|  |     |||||||.|.||||.||.. |....| |    .|.   .  || ||||.|..
wpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvkt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 5-183 2.4e-46 153.1 In-house 86-261 (315) alignment 
Range on Protein: 5-183
Range on HMM: 86-261/315.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPD--SGTQIYGFFEITLHSIREYPDYILRELkIVdsRDAEgSSQHVKQFQYV
 ||.||.||||. . |||||||...| .||||... .|  |  | .||||  . .  .| ....| |.    | . |.| ..  |..| .|. | |||. 
dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt..rkse.esrtvtqfqft

SWPSKGVPDSAIGLLDVREQVEKWqRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
 || |||.  .  || .  .|    ... . ...|||| | ||||  |..   ..|.| .  ||||..|. || .|| .|.
ewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-185 5.6e-46 151.9 In-house 86-265 (439) alignment 
Range on Protein: 1-185
Range on HMM: 86-265/439.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKamchkYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQ
|| . | .||||||  .|||||||.|.| |..|||||.|  |  |     ||| ..  .||   .      | |.|..| .|... ||     . | ||.
Gyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfh

YVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|..|| | ||  |  .||    ..  . .    |.||||| | ||||| ||. . ..|||.|  ||.  .|. || ||  ||...
yiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqal
subfamily_CG7180_pd Subfamily CG7180 1-185 2.8e-45 149.2 In-house 80-276 (296) alignment 
Range on Protein: 1-185
Range on HMM: 80-276/296.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKaMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDS--------RDAEGS
.. | |..| |..|  .| |.|||.|.. ..|..|.|... .  | |...|||  . . || ... . . ..|..   |..|..          .. .  
sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkae

SQHVKQFQYVSWPS-KGVPDSAIGLLDVREQVEKWQRDS----GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
   ||.||.  |.. . || |. .|...|..|..|..        .|.||..| | .|.| |.|.   ..... |. ||||. |. || .||..| .|
tRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-185 2.8e-45 149.3 In-house 75-263 (287) alignment 
Range on Protein: 1-185
Range on HMM: 75-263/287.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT--QIYGFFEITLHSIREYPDYILRELKIVDsrdAEGSS-QHVK
.| . .||||.|||.. |  ||||.|.| .|....... | | ..  |.||||.     .. |.  . |      |.|  | |...|   .|.   . ||
sytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlid...letrearvvk

QFQYVSWPSKGVPDSAIGL----LDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
|....|||.|... .|.||    |||....|  .  |.  |.|||.. | ||.|...|.  |...|.  | ||| .||  || .| ..|..|
qldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav
0051429 (Phosphotyrosine protein) phosphatases II 3-186 3.9e-45 149.9 In-house 19-212 (272) alignment 
Range on Protein: 3-186
Range on HMM: 19-212/272.0
CKRKAFIATQGPLPDTTDDFWRMvWEYKSSTIVMLANERERGKAMCHKYWP------------DSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAE
 |........|||| | .||||. .|.. .|||.| .| |||.  |..|||            .  |  ||.. .||.|.  ..||||||| ..   .|.
vkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

GSsQHVKQFQYVSWPSKGVPDSAigLLDVREQVEKwqrdsgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVD--------VFQVVRGLRLQRPGMV
 .  .| ...| .||  |||..|  ||.. |.. .      ..|..||||.|..||||..|. ||. .. .|  ||        ....|. || ||||.|
ea.revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgav

RSVM
 . .
qtee
0036282 (Phosphotyrosine protein) phosphatases II 5-184 3.3e-44 146.0 In-house 16-155 (174) alignment 
Range on Protein: 5-184
Range on HMM: 16-155/174.0
RKAFIATQGPLPdttddFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDsgtqiygffeitlhsireypdyilrelkivdsrDAEGSSQHVKQFQYVSW
 . .||.||||.     ||.|..|....|.||| .|.|.|. .|. |||.                                 . |  .... |..|. |
tprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lredlerlgiqylylpw

PSKGVPDSAIgLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKaEGLVDVFQVVRGLRLQRPGMVRS
|  ||||..| ||.. ..||... .....|..||||.|.||||| .|. |.. .|. |.|||....|| ||||||||| .
pDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 5-183 4.3e-42 139.0 In-house 44-223 (237) alignment 
Range on Protein: 5-183
Range on HMM: 44-223/237.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG-TQIYGFFEITLHSIREYPDYILRELKIVDSRDAEgSSQHVKQFQYVS
 | .||.||||  . ||||.|||. | | ||||.   |. .  ||||||..   . || . ..|.   |. || .| | ..     .   . ..|.|. |
pkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlk.evrlihqyqfts

WPSKGVPDSAIGLLDVREQVEKWQRD-SGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
|| .|||. .  ||  | .. .  .  |   | ..||| | |||| .. .  .. | | . .||... |  .  .|| ...
wpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiq
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4-184 6.7e-42 138.3 In-house 62-249 (270) alignment 
Range on Protein: 4-184
Range on HMM: 62-249/270.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQ----IYGFFEITLHSIREYPDYILRELKIVdsrdAEGSSQHVKQF
..|..||..|||| |. .||||.|| |...|||...  |.|.  | .||| .  .     .|. ...  | .    |||..|..      .|.....  |
ekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle....ekgeerrlvHf

QYVSWPSKGVPDSAI------GLLDVREQVEKWQRDSGDK-PIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
.|..|| .||| ..        || . ..| .....  .. |..|||| | ||||| ||.   .  |. .. ||| .... || .|. .|. 
wyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqh
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 5-184 1.5e-41 137.1 In-house 51-226 (239) alignment 
Range on Protein: 5-184
Range on HMM: 51-226/239.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSgTQIYGFFEITLHSIREYPDYILRELkiVDSRDAEGSSQHVKQFQYVSW
 ||.||||| .  .. |||||.|. .   ||||.   |  |  ||.||||| |  |  . .||.    . |||.| .  | |.  .   ..| |...  |
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskycnlrvtlrktevfadyiirtf..vmsqvgqteeryvyqyhftvw

PSKGVPDSAIGLLDVREQVEKWQrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
| ||||. |  .| .| .. |     | .| |.||| | ||||... .  .. | | .  ||.|. |. .| .|| ||..
pdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 5-184 1.5e-41 137.1 In-house 50-225 (239) alignment 
Range on Protein: 5-184
Range on HMM: 50-225/239.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSgTQIYGFFEITLHSIREYPDYILRELkiVDSRDAEGSSQHVKQFQYVSW
 ||.||||| .  .. |||||.|. .   ||||.   |  |  ||.||||| |  |  . .||.    . |||.| .  | |.  .   ..| |...  |
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskycnlrvtlrktevfadyiirtf..vmsqvgqteeryvyqyhftvw

PSKGVPDSAIGLLDVREQVEKWQrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
| ||||. |  .| .| .. |     | .| |.||| | ||||... .  .. | | .  ||.|. |. .| .|| ||..
pdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqt
0049260 (Phosphotyrosine protein) phosphatases II 2-184 9.2e-39 127.9 In-house 5-135 (152) alignment 
Range on Protein: 2-184
Range on HMM: 5-135/152.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWpdsgtqiygffeitlhsireypdyilrelkivdsrdaegssqhvkQFQY
| . ..|||||||.| |..|||||..|.. .||||| .. |.||  |..|.                                             |...
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylh

VSWPSKGVPDSAIGLLDVREQVEKWqRDSGDKPIVVHCSGGCGRTGTYIAMCLLIdqlkaeGLVDVFQVVRGLRLQRPGMVRS
. ||  ||||... ||.. . .||. . . ..|..||||.|.|||||..|. |..        |.....|. .| .|||.| .
lpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpn
subfamily_PTPN14_pd Subfamily PTPN14 4-185 1.5e-38 127.5 In-house 91-282 (300) alignment 
Range on Protein: 4-185
Range on HMM: 91-282/300.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS----GTQIYGFFEITLHSIREYPDYILRELKIVDSRdaEGSSQHVKQF
|.. .|..||||. |  |||.|||| . . ||||..|.| ||  ..||.|..     |  .| |..| .  .. . .| . ||.       .  . |  .
kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp..skeertvwhl

QYVSWPSKGVPDSAIGLLDVREQVEKWQRDS--------GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
||. || .|||.   | |.  |.|.  .| .         . |..|||| | ||||  |   |||  |. .  .|. .|.. || ||  .|...
qytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl
subfamily_PTPN1_pd Subfamily PTPN1 5-183 2.1e-37 123.4 In-house 70-255 (290) alignment 
Range on Protein: 5-183
Range on HMM: 70-255/290.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT---QIYG--FFEITLHSIREYPDYILRELKIVDSRDAEgsSQHVKQF
.. .| ||||||.|.| ||.|||| || ..||| .  |...  |..|||        ..    ....| |  ..  |..| |.. . .  |  .... .|
krsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqe..treilhf

QYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGD-KPIVVHCSGGCGRTGTYIA--MCL-LIDQLKAEGLVDVFQVVRGLRLQRPGMVR
 |..||  |||.|   .|.   .| .    | |  | |.||| | ||.||..    || ||.. .    ||. .|.  || .| |...
hyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliq
0041856 (Phosphotyrosine protein) phosphatases II 1-184 3.9e-37 123.0 In-house 29-156 (182) alignment 
Range on Protein: 1-184
Range on HMM: 29-156/182.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLAnerergkamCHKYWPdsgtqiygffeitlhsireypdyilrelkivdsrdaEGSSQHVKQFQ
|... . ||||||||..|. ||.||..|.. .|||.|.         .. |||                                    |   ... |..
gslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp....................................ellerlgiqyl

YVSWPSKGVPDsAIGLLDVREQVEKwqrdsGDKPIVVHCSGGCGRTGTYIAMCLLIDQlkaeGlVDVFQVVRGLRLQRPGMVRS
|..||  ||||    |||  |.|..      ..|..||||.|.|||||..|. |.. .    | |.....|. .| .||||| .
ylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvit
0043147 (Phosphotyrosine protein) phosphatases II 2-185 1.6e-36 121.0 In-house 16-147 (172) alignment 
Range on Protein: 2-185
Range on HMM: 16-147/172.0
YCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANErergkamchkywpdsgtqiygffeitlhsireypdyilrelkivdSRDAEGSSQHVKQFQY
| . . ||||||||. |..|||||..|.. ..||.| ..                                               |.|. .... |..|
yyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydpellerlgiqyly

VSWPSKGVPdSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIdqlkaEGLvDVFQVVRGLRLQRPGMVRSV
..||  ||| ..  ||.. |......  | ..|..||||.|.||||| .|. |..     .|| .....|. .| .|||.| . 
lpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnp
0046846 (Phosphotyrosine protein) phosphatases II 7-184 3.6e-36 119.9 In-house 24-158 (176) alignment 
Range on Protein: 7-184
Range on HMM: 24-158/176.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDsgTQI--YgffeitlhsireypdyilrelkivdsrdaegssqhvkQFQYVSW
..||||||||.|. ||..|..|.. ...|.| .|.| |.  |. |||.   .   .                                     |.... |
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.....................................qylhlpw

PSKGVPDSaIGLLDVREQVEKWQRDSgdKPIVVHCSGGCGRTGTYIAMCLLIDqlkaEGLVDVFQVVRGLRLQRP-GMVRS
|  ||||.   ||.. |........   .|..||||.|.|||||..|. ||.     |  ..|..... .| ||| |.| .
pDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 6-182 1.3e-34 114.2 In-house 94-266 (290) alignment 
Range on Protein: 6-182
Range on HMM: 94-266/290.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIRE-YPDYiLRELKIVDSRDA-EGSSQHVKQFQYVS
  || |||.| ||. |.|||| . | ..|||| .  | ||| |..|.|.   ..  | |||.    |  .|     .|..  ||  .| .  .| .. .|
amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkda.niikktlsvrdkdsGkehklkhlkiks

WPSKGVPDSAIGLLDVREQVEKWqrdSGdkPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMV
|| | |. |.. || .   . |    ||  |.||||| | |||||..|.   .. |     .|. ..|| ||  | . |
wpdksvalstlallrtlrilrka...sG..pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 6-180 3.1e-34 113.1 In-house 90-262 (301) alignment 
Range on Protein: 6-180
Range on HMM: 90-262/301.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIY--GFFEITLHSIREY--PDYILRELKIVDSRDaEGSSQHVKQFQY
. ||||||||..|..||| |.  |.  .||||....|. . .|..| | . ..    | |.|....       . . |.|...|| . . ... |  .||
hrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg.kfatrtvthyqy

VSWPSKGVPDSAIGLLDVREQVEKwqrdsGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPG
..|. .||| | . | |. | | |      .|||||||| | ||. ..|.   |  ...|.  ... . .. || .|  
sewtdrgvPkshaelfdlmelvkk.....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwn
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 5-185 9.8e-33 108.0 In-house 4-190 (199) alignment 
Range on Protein: 5-185
Range on HMM: 4-190/199.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWP--DSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQYV
.. .|||| || .|  |||.||||  |  |||. ...   .|    |||  .|||  || . .| ..|   ||| .  | ....  |  |.. . ..|. 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPSKGVPDSAI--GLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQL--KAEGLVDVFQVVRGLRLQRPGMVRSV
||  |  |. |.  |..    .| |   .  | |..|||| | | || ..|. . .         .||.|.| . ||  | |.. |.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 6-185 1e-32 107.9 In-house 4-189 (198) alignment 
Range on Protein: 6-185
Range on HMM: 4-189/198.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWP--DSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQYVS
. .|||| || .|  |||.||||  |  |||. ...   .|    |||  .|||  || . .| ..|   ||| .  | ....  |  |.. . ..|. |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPSKGVPDSAI--GLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQL--KAEGLVDVFQVVRGLRLQRPGMVRSV
|  |  |. |.  |..    .| |   .  | |..|||| | | || ..|. . .         .||.|.| . ||  | |.. |.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl
0051082 (Phosphotyrosine protein) phosphatases II 8-184 1.5e-31 104.4 In-house 15-138 (151) alignment 
Range on Protein: 8-184
Range on HMM: 15-138/151.0
FIATQGPlpdtTDDFWRMVWEYKSSTIVMLANERERGkaMCHKYWPDSGtqiygffeitlhsireypdyilrelkivdsrdaegssQHVKQFQYVSWPSK
.....||    ..||.....|.. .|||.| .| |||  .|..|.|. |                                      .|.......||  
lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.....................................ievlhipildwpdp

GVPDSAIGLLDVREQVEKwqrdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQlkaeglVDVFQVVRGLRLQRPGMVRS
|.|.|   .|.. |....     ...|..||||.|.||||| .|. |.. .      |....... .||.|||.|..
glplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp
0049772 (Phosphotyrosine protein) phosphatases II 6-183 2.1e-30 102.0 In-house 84-264 (314) alignment 
Range on Protein: 6-183
Range on HMM: 84-264/314.0
KAFIATQGPLPDTTDDF----------WRMV--WEYKSSTIVM---------------------LANERERGkamchKYWPDSGTQIYGffeitlhsire
..||||||||. | .||          ||||  ..... .|||                     | .  ..|      ... .  . .            
lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk...........

ypdY-------IlrelkivdsrdaegsSQHVKQFQYVSWPSkGVPDSAIGLLDVREQVEKWqrdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKaeglV
                           .... .. .. .|  | ...   .... | .|..   . ..|..|||..|.|||||......|. .|.    |
...eelydpelf...............erlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....v

DVFQVVRGLRLQRP-----GMVR
.. .... .||.||     |...
sleealedvrlkRpinpnpgfie
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 5-183 6.6e-30 98.8 In-house 87-220 (392) alignment 
Range on Protein: 5-183
Range on HMM: 87-220/392.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGkamchkywpdsgtqiygffeitlhsireypdyilrelkivdsrdAEGSSQHVKQFQYVSW
 ||.||.||| . . |||||||.. . .||.|... .|                                                 . . | ||... |
ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............................................kgddartvaqfhftew

PSKGVPDSAIGLLDVREQVeKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
| |.||  .  || . ..| | .  .  .|...||| | ||||  |..  .. . |   .||||..|  .| .|| ||.
Pdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvq
PTPc_DSPc_SM00012 96-185 3e-29 96.7 In-house 2-93 (105) alignment 
Range on Protein: 96-185
Range on HMM: 2-93/105.0
VKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSG-DKPIVVHCSGGCGRTGTYIAMCLLIDQLKAE-GLVDVFQVVRGLRLQRPGMVRSV
||...| .|| .|||...  .|.. ..|.|....|.  ||.||||| |.|||||..|...|..||..| . ||.||.|. || ||||||.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
subfamily_ptpA1_pd Subfamily ptpA1 5-159 1.9e-28 94.3 In-house 88-256 (418) alignment 
Range on Protein: 5-159
Range on HMM: 88-256/418.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS-----------GTQIYGFFEITLHSIREYPDyilRELKIVDSR-DAEGS
 | ||.||||||.|  |||||||| .   ||||. | |  .  | .|||.            | ...| . . |  . . |.   ||.   . |   || 
pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe...reiitrnirltfege

SQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRD---SGD--KPIVVHCSGGCGRTGTYIAMCLLIDQL
.. . |.||  || . .|| .  . ..   . . | .   | |   ||.|||| | |||||. .  ... .|
trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4-180 4.1e-28 93.3 In-house 80-258 (307) alignment 
Range on Protein: 4-180
Range on HMM: 80-258/307.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFE----ITLH---SIREYPDYILRELKIVDSrDAEGSSQHV
| | ||..|||| .|  .|| |. . |  ...||..  | .|  |..|||    |   | |    |..    . .  ||  | ..  ..  |  . |. .
kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkv.dwaqksrti

KQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrdsGDKPIVVHCSGGCGRTGTYIAMCLLIDQL-KAEGLVDVFQVVRGLRLQRPG
...|.  || .|||.  .. ... | |.         |.||||| | ||.|| .|..|. |.. . .   |. ..|. || ||. 
qhlqwenwpdrgvpqinltainlleavry.....dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1-183 6.2e-28 92.5 In-house 67-243 (267) alignment 
Range on Protein: 1-183
Range on HMM: 67-243/267.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANErerGKAMCHKYWPDSGTQIYGFFEITL-HSI-REYPDYILRELKIvdsRDAEGSSQHVKQ
|| ...|||.||.||  |  ||. .. ..| ..||.| .    ..   ...||    |   . ..|. ||. .|  || .  |..   .  . |.. |  
gyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfknesahnvtl

FQYVSWPSKGVPDSAigLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
. |  |  .        |  .   . | | . |..|.||.|| | ||.||.. .   ....| || .|.|. .| .| ||.|.| 
yyykkwnintnnkpy..lkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvd
0044763 (Phosphotyrosine protein) phosphatases II 12-184 5.5e-27 90.0 In-house 35-156 (178) alignment 
Range on Protein: 12-184
Range on HMM: 35-156/178.0
QGPlpdttDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTqiygffeitlhsireypdyilrelkivdsrdaegssqhvKQFQYVSWPSKGVPD
..|      |......|.. ..||.|..| |.|.  |..|||..                                          |.... .|  ||||
lpp.....addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipipDhgvpd

SAIGLLDVREQVEKWQRDSGdKPIVVHCSGGCGRTGTYIAMCLLIDQlkaeGLvDVFQVVRGLRLQRPgMVRS
.   .|.. | .|... ..| .|..|||| | ||.|| .|. |.. .    || ....... .| .|| .| .
llehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 6-186 8e-27 88.9 In-house 75-257 (285) alignment 
Range on Protein: 6-186
Range on HMM: 75-257/285.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQI--YGFFEITLHSIREY--PDYILRELKIVDSRDAEGSSQHVKQFQY
 ..|.||||||.|  |||.|... | . ..||.   | |   |  |.|.   ..  .| .||||   .|      ||  | .... ||     .... | 
styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqv

VSWPSKGVPDSAIGLLDVREQVEKWQrdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSVM
  || .  |. |  .... . |.| .    .|||.|||| | ||| |.. .     ..  .  ......|| .|  |   |.| |
pwwpdqlapedarpmielykwvkkvn..pkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshm
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 5-178 1.5e-24 81.2 In-house 95-268 (305) alignment 
Range on Protein: 5-178
Range on HMM: 95-268/305.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT-QIYGFFEITLHSIR-EYPDYILRELKIVDSR--DAEGSSQHVKQFQ
 | ||..|||| .| |.|| || . |   ||||..  | ||  | .||| .   .      | .  .    |     |..|   .   . . .  |...|
ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlq

YVSWPSKGVPDSAIGLLDVREQVekwqRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEG-LVDVFQVVRGLRLQR
.  || .|||   .  |..   .    | |   ||||||| | ||||| .|.  .....  .     . ..|. || ||
wtewpdrgvppckltslellsai....rgs.kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqr
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 5-178 3.5e-23 76.8 In-house 87-266 (305) alignment 
Range on Protein: 5-178
Range on HMM: 87-266/305.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITL-----------HSIREYPDYILRELKIVDsRDAEGSS
 | || || || .|  ||| | .. |  .| || |  |.|   |..|..    ..  | |               ..|.  .  ..| ..|    . ...
pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlvi.egpgeka

QHVKQFQYVSWPSKGVPDSAIGLLDVREQVekwqRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVD-VFQVVRGLRLQR
..|... .. || .||| . . .|.. |.     | |   ||||||| | ||||. . .  ..||| |   ..   .... .| ||
rkvthyhwidwpdrgvpaadlailelleka....rps.kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 5-178 1.8e-22 74.3 In-house 93-269 (310) alignment 
Range on Protein: 5-178
Range on HMM: 93-269/310.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG-TQIYGFFEITLHS--IREYP-----DYILRELKIVDSRDAEGSSQHV
|..|| .||||  |  |||||... .. .|..| .  | |.  |  |||  | |. ||   .|  |    |.        .. .   || . |.     |
rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrv

KQFQYVSWPSKGVPDSAIGLLDVREQVekWQRdsgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQR
.  ..  || .||||     .  |       |     | ||||| | .|... .|. | ||.|.    ||. .|.  |. .|
slikwpnwpdrgvpdekchtvpqrlla..qvr...hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 5-181 2.4e-22 74.3 In-house 81-253 (288) alignment 
Range on Protein: 5-181
Range on HMM: 81-253/288.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYpDYILRELKIVDSRDAEG--SSQHVKQFQYV
.. .| .| ||  | . .|.|. |     ||||..  |.||    .|.|    .   .  .     ... . | . .|.   |  .    .. ||.  . 
krrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr.adidklvkvsllriskegeekvivkilhll

SWPSKGVPDSAIGLLDVREQVekwqrDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGM
 |. .|||.. .  | . | .      | .||||||.| | ||||| | . . ...|. .  . . ...  || .|   
eWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfka
0048076 (Phosphotyrosine protein) phosphatases II 67-184 3.7e-22 74.0 In-house 36-128 (145) alignment 
Range on Protein: 67-184
Range on HMM: 36-128/145.0
LhsireypdyilrelkivdSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSgdKPIVVHCSGGCGRTGTYIAMCLLIDqlkaEGlVD
|                  ... |. .... |..|..||  ||||..  ||.. |..|.....   .|..|||| |.|||||..|..|..     .| |.
l..................tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vs

VFQVVRGLRLQRPGMVRS
...... .| ||||.| .
leealelvrsqrpgavpn
0048179 (Phosphotyrosine protein) phosphatases II 80-184 5.8e-22 73.4 In-house 48-130 (144) alignment 
Range on Protein: 80-184
Range on HMM: 48-130/144.0
ElkivdsrdaegssqhVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRdsGDKPIVVHCSGGCGRTGTYIAMCLLIdqlkAEGlVDVFQVVRGLRLQRP
|               . |.....||  ||||..  ||.. | .|....   ..|..||||.|.|||||..|..|..     .| ........ .| .||
e...............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrp

GMVRS
|.| .
gavpn
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 5-177 1.4e-21 71.4 In-house 80-246 (281) alignment 
Range on Protein: 5-177
Range on HMM: 80-246/281.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLhsirEYPDYILRELkIVDS---RDAEGSSQHVKQFQY
.. .| ||||  .|  |||||.|. ....||||..  |  .  | .|.|        | ....    .| |  . .  .| .      || .. . .. .
krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsv....syedstvnks.lvttrlnlsyegetrlithwlw

VSWPSKGVPDSAIGLLDVREQVEkwqrdSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAE-GLVDVFQVVRGLRLQ
  ||   ||.|.  .| .  ..      .   | |.||| | ||.|| .|. . .. ...   | |. |.|  ||. 
kewpdwqvpessevmlkilrkir.....arstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 7-112 2.6e-21 70.8 In-house 77-182 (297) alignment 
Range on Protein: 7-112
Range on HMM: 77-182/297.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSI----REYPDYILRELKIVDSrdaeGSSQHVKQFQYV
 .| .|||| .| ||||..|.|    .|||.|. .| |.  |  |||..  .     .. .  .     |.   || ||...        |..|.  |..
kyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqfl

SWPSKGVPDS
||| .|||  
swpdhGvpsd
subfamily_egg_pd Subfamily egg 7-186 4.8e-21 69.7 In-house 84-257 (307) alignment 
Range on Protein: 7-186
Range on HMM: 84-257/307.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERgkAMCHKYWPDSGTQ----IYGFFEITLHSIREYPDYILR--ELKIVDSRDAEgssQHVKQFQ
 || .| || .| |||||||.. .   ||||.  .|     |. ||| . ..    . | ..|.   . . .| ..|  .||.| . | |   .... .|
efilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddee...rflehwq

YvSWPSKGVPDSAIGLLdvreqveKWQRDSgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEG--LVDVFQVVRGLRLQRPGMVRSVM
.  .   .   | . .|       .  |.   ||.||..  |. ...| .|. . . .|         | . |  |||.|.  | ||.
g.dvnnssdvysplrvl.......rklrnl.skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 18-157 1.6e-20 68.3 In-house 40-173 (255) alignment 
Range on Protein: 18-157
Range on HMM: 40-173/255.0
TTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIGLL
| | |....   |....|||..  | |.  |..|.|    .   . .... . .   | .|| |.|.         . || ..|  |. |  |. |  .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DVReqveKWQRDSgdKPIVVHCSGGCGRTGTYIAMCLLID
 .     |  |||  |..||||| | ||. ... . |.  
nil....kvvrds..ksvvvhCstGiGrsaafvlaelvyq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 4-170 5.8e-20 66.2 In-house 80-247 (312) alignment 
Range on Protein: 4-170
Range on HMM: 80-247/312.0
KRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDsgtqIYGFFEITLHSIR-EYP----------DYI-LRELKIVdsRDAEG
| . |..||||| .|.  ||...    |..|..|.   | |   | ||  |    | || ..  | .  ||           | |  | ||.|    | |
kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd....ivgfvdledhrvyteycteieiggkskdkithrvlkvv..vkatg

SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKwqrDsgDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQV
   .....|. ||| .|.|||    | .   | |   |   ||.. ||| | ||||| . .  .|  |.     .| ..
qesklnhyqwaswpdhgmpdscdtalrllsavkk...d..kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkds
subfamily_CG42327_pd Subfamily CG42327 6-119 1.1e-19 65.3 In-house 72-186 (319) alignment 
Range on Protein: 6-119
Range on HMM: 72-186/319.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS----GTQIYGFFEITLHSIREYPDYILRELKIvDSRDAEgSSQHVKQFQY
  .||.| .| |.. ||||.||| .| .|| |..  | |  .| .|.| .    .|. || . .||        |..  | .    | |  |...  . |
nsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlll.krvdke.esrelthywy

vSWPSKGVPDSAIGLLDV
  |.  .|| .   |. .
.kwleaevPaeeaaliam
subfamily_hpo-7_pd Subfamily hpo-7 16-155 2.5e-18 60.9 In-house 44-177 (263) alignment 
Range on Protein: 16-155
Range on HMM: 44-177/263.0
PDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQIYGFFEITLHSIREYPDYILRELKIVDSRDAEGSSQHVKQFQYVSWPSKGVPDSAIG
 .| | |....   |....|||..  | |.  | .|.|    .   . .... . .   | .|. |...   .     . ||...|. |. |  |  |. 
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

LLDVReqveKWQRDSgdKPIVVHCSGGCGRTGTYIAMCLL
 | .     |  |.|  |..||||| | ||.  .  . |.
ilnil....kvarns..kslvvhcstGiGrsaafsvaElv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 92-184 1e-17 58.6 In-house 87-179 (440) alignment 
Range on Protein: 92-184
Range on HMM: 87-179/440.0
SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
 |. .||..| .|| ||||  |  .| . ..|.. |  .|. |..|||| |.||||  ||.  .. . |    .|.| ..  .| .|| ||..
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqt
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 14-183 1.6e-17 57.9 In-house 99-272 (302) alignment 
Range on Protein: 14-183
Range on HMM: 99-272/302.0
PLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGTQI--YGFFEITLHSIR----EY---PDYILRELKIVDSRDAEGSSQHVKQFQYVSW
|  .|.. .| .. .|. . .| |..  | ..  | .|. |   .   .| . ..  |..    |.    .. |  ..| ...  .   . |. ... .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PSKGVPDSAIGLLDVREQVEKWQRDsgdkpIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVR
| .| |. |   ||.    | ....     ..|||| | ||||| .|.   |.  . .   |. ..|  .|  | | |.
pdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1-56 7.1e-14 46.0 In-house 231-283 (440) alignment 
Range on Protein: 1-56
Range on HMM: 231-283/440.0
GYCKRKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERgkaMCHKYWPDSG
|| |..|||||| ||  |  ||||.| .|. |||.|| .  ..    |  |||   
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvnt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 8-57 8.9e-14 45.9 In-house 106-155 (350) alignment 
Range on Protein: 8-57
Range on HMM: 106-155/350.0
FIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSGT
.||||.||| | |||.... . |   |..|... | .   |..||.. . 
YiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 6-185 1.4e-13 44.9 In-house 90-271 (302) alignment 
Range on Protein: 6-185
Range on HMM: 90-271/302.0
KAFIATQGPLPDTT---DDFWRMVWEYKSSTIVMLANERERGKaMCHKYWP-DSGT-QIYGFFEITLHSIREYPDYI-LRELKIVDSRDAEGSSQHVKQF
.  | .| |  |..   ..|||||.. |  ..|.|. | |  |   ....|  ||. . || . .    . .  .      . ..    ..     |. .
rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvl

QYvsWPSKGVPDSAIGLLDVREQVeKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
..  |..| ||..   |    ..|   .  ..|...|.    |.|| |. ... . ...|...  . . ..|. .| ||| .| |.
tn..Wkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdsl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 7-182 1.5e-13 45.6 In-house 61-242 (290) alignment 
Range on Protein: 7-182
Range on HMM: 61-242/290.0
AFIATQGPLPDT-------TDDFWRMVWEYKSSTIVMLANERERGKA----MCHKYWPDSGTQIYGFFEITLH--SIREYPDYILRELKIVDSRdaeGSS
..|.|| |. ..         .|| |. . |.  .||| .  |. .      | || |.|  ..  |  .|..  |  .  | . ||| .       .  
rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd...eee

QHVKQFQYVSWPSKGVPDSAIGLLDVREQVEKWqrdsgDKPIVVHCSGGCGRTGTYIAMCLLIDQLK-AEGLVDVFQVVRGLRLQRPGMV
  |.  ....| .  |... . ||.. ..|..      . |..|||  |  |  .  |. |    .   .| | . .|.  || ||  ..
ftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralai
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 135-182 1.5e-13 44.9 In-house 1-48 (69) alignment 
Range on Protein: 135-182
Range on HMM: 1-48/69.0
IVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMV
.||||| | |||||.||. . . ..|.| |||.|  |. .|  || ||
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 136-182 4.1e-13 43.5 In-house 1-47 (69) alignment 
Range on Protein: 136-182
Range on HMM: 1-47/69.0
VVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMV
||||| | |||||.||. . . ..|.| |||.|  |. .|  || ||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmv
0038934 (Phosphotyrosine protein) phosphatases II 100-178 4.9e-11 38.1 In-house 81-162 (194) alignment 
Range on Protein: 100-178
Range on HMM: 81-162/194.0
QYVS--WPSKGVPDSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLI-DQLKAEGLVDVFQVVRGLRLQR
.|..  .|..|.. |   ||.  . |... ... .. ..||| .| ||||| .|  |.   ...||  .. |. .|.  ...
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipn
subfamily_eak_pd Subfamily eak 8-110 6.9e-11 36.1 In-house 95-195 (332) alignment 
Range on Protein: 8-110
Range on HMM: 95-195/332.0
FIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSG--TQIYGFFEITLHSIREYPDYILRELKIVDSRDaegsSQHVKQFQYVSWP
.| |  .  |    ||.|| | || .||.|... | .     ||.|| .     .|.....  .  .   .  | |..    .    . .|. ...  | 
yiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGne....thrvlhykvfGwt

SKGVP
   .|
ettlp
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 7-109 1e-10 35.6 In-house 138-235 (244) alignment 
Range on Protein: 7-109
Range on HMM: 138-235/244.0
AFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERgkamcHKYWPDSGTQIYGF--FEITLHSIREYPDYILRELKIvdSRDAEGSSQHVKQFQYVSW
 .| || || ||. |||.|. | .   .|.|    |       .|||||    .      .||    |. .    .|.|    | . | | .  ||   |
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnlei..esdmneshqaltmfqisnw

PSKGV
|| | 
psdgt
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 6-177 1.3e-10 35.4 In-house 83-254 (303) alignment 
Range on Protein: 6-177
Range on HMM: 83-254/303.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDSgtQIYGFFEITLHSIREYPDYILR---ELKIVDSRDAEGSSqHVKQFQYV
|  | || ||. |. |||.|. | |   ...|  . |  |   .  .|    | .  ||     . |.    |     ||..   . .  |  ..  .| 
kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn..qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyks.flhvhhyk

SWPSKGVPDS-AIGLLDVREQVEKWQRD-SGDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGlvDVFQVVRGLRLQ
.|| . .|   .  ..    |..   |  |  .| |     ||||.||.  .      |..|     ...|. |   
awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseq..asldlvkclenv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 95-158 1.8e-10 35.1 In-house 216-288 (350) alignment 
Range on Protein: 95-158
Range on HMM: 216-288/350.0
HVKQFQYVSWPSK---GVPDSAIGLLDVREQ------VEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQ
 | |.|.  |.       | | .  |.|...       |..  ..  .||.|||| |.|||||....  |. .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsd
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 6-109 6.2e-10 33.5 In-house 28-126 (130) alignment 
Range on Protein: 6-109
Range on HMM: 28-126/130.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERgkamcHKYWPDSGTQIYGFFEITLH-SIREYPDYIlRELKIVDSRDAEGSSQHVKQFQYVSW
. .. || || ||. |||.|. |     .|.|    |       .|||||    .   .|..  . |.  ..| .  ..  ..|   | | .  ||   |
aeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkni.kasnleiesdlneshqaltmfqisnw

PSKGV
|| | 
psdgt
PTEN_1 98-161 7.7e-10 33.9 In-house 94-160 (196) alignment 
Range on Protein: 98-161
Range on HMM: 94-160/196.0
QFQ--YVSWPSKGVPDSAIgLLDVREQVEKW-QRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQ-LKA
...   ....  |.|. .  |.|. .... | ..|.  . ..||| .| ||.|| .|..|.  . | |
gveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgklta
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 6-55 3.7e-09 30.4 In-house 107-156 (349) alignment 
Range on Protein: 6-55
Range on HMM: 107-156/349.0
KAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLANERERGKAMCHKYWPDS
| .|||| ||| | |||....   .   .. | .. | .   |..|| . 
kkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_CG42327_pd Subfamily CG42327 131-182 6e-09 30.0 In-house 246-298 (319) alignment 
Range on Protein: 131-182
Range on HMM: 246-298/319.0
GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAE-GLVDVFQVVRGLRLQRPGMV
   |.||||| | ||||. ||  . | .|.     ||. |.|  .| .|   |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasav
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 95-158 1.3e-08 28.6 In-house 219-291 (349) alignment 
Range on Protein: 95-158
Range on HMM: 219-291/349.0
HVKQFQYVSWPSKGV---PDSAIGLLDVREQV------EKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQ
 . |.|.  |.  ..   | | .  |.|....      ...  ..   ...|||| ||||||... . ||.. 
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsi
subfamily_PTEN_pd Subfamily PTEN 116-164 6.7e-08 27.7 In-house 98-145 (184) alignment 
Range on Protein: 116-164
Range on HMM: 98-145/184.0
LLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAmCLLIDQLKAEGL
| .. |..|||   . .. .||||  | ||||. |. ..|. .|. |  
leeivediekwleedkknvvvvHCkaGkGRtGvliv.ayllksllleka
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 121-184 6.9e-08 26.7 In-house 216-280 (297) alignment 
Range on Protein: 121-184
Range on HMM: 216-280/297.0
EQVEKWQRDS-GDKPIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRS
 |.|  . .   . ...|||| | ||.|  .    ....|. . . ||  ... || ||. .|..
lqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqt
subfamily_DSP11_pd Subfamily DSP11 98-182 3.4e-07 24.3 In-house 81-167 (178) alignment 
Range on Protein: 98-182
Range on HMM: 81-167/178.0
QFQYVSWPSKGVPDSAIgLLDVREQVEKWQ--RDSGDKPIVVHCSGGCGRTGTYIAMcLLID--QLKAEGLVDVFQVVRGLRLQRPGMV
... .  | . ||.. . . .  |.|...   ..  || | |||  |  |||  |    |||  ....|  ...|. .||  |.|   .
kylklncpGhevpkeel.vkkfkeavkefleknkdndkligvhCthGvnrtGyliCr.ylidvegyepedaieafeearGhslerenyl
subfamily_CDC14_pd Subfamily CDC14 133-183 3.5e-07 24.4 In-house 264-309 (328) alignment 
Range on Protein: 133-183
Range on HMM: 264-309/328.0
KPIVVHCSGGCGRTGTYIAmCLLIDQLKaeglVDVFQVVRGLRLQRPGMVR
  |.|||  | ||||| || | |. . .    .   ...  ||. |||.| 
GaiavhCkaGLGrtGtLia.cylmkhyr....ftaaeaiawlricrPGsvi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 5-38 1.2e-06 22.3 In-house 84-117 (347) alignment 
Range on Protein: 5-38
Range on HMM: 84-117/347.0
RKAFIATQGPLPDTTDDFWRMVWEYKSSTIVMLA
.| .| || |||||  |||.||   | . .| . 
skeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_VSP_pd Subfamily VSP 115-158 1.3e-06 22.5 In-house 111-154 (212) alignment 
Range on Protein: 115-158
Range on HMM: 111-154/212.0
GLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAMCLLIDQ
 || . ..|..|  .  .. ...|| || ||||| .   ||  .
ellvftkevkewlekdlknvlaihckGGkgrtGtivcalllase
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1-51 2.6e-06 21.2 In-house 70-121 (332) alignment 
Range on Protein: 1-51
Range on HMM: 70-121/332.0
GYCKRKAFIATQGPLPDTTDD-FWRMVWEYKSSTIVMLANERERGKAMCHKY
|| |. |.| .| |. | |.  ||||| | | | |... .  |. |  .   
gyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapyd
0048567 (Phosphotyrosine protein) phosphatases II 66-160 3.4e-06 21.5 In-house 52-105 (157) alignment 
Range on Protein: 66-160
Range on HMM: 52-105/157.0
TLHSIREYPDYILRELKivdsrdaegssqhvkqfqyvswpskgvpdsaiglldvreqvekwQRDSGDKPIVVHCSGGC---GRTGTYIAMCLLIDQLK
.|. . ..  .. . ||                                            . .  .|.|.|||. |    |||.| |.  |.. . .
nlailyrFilklnkflk............................................ilelagkaiavhckaglkkrgrtatLigcYlilhlgf
subfamily_DSP23_pd Subfamily DSP23 132-184 5.6e-06 21.1 In-house 84-131 (148) alignment 
Range on Protein: 132-184
Range on HMM: 84-131/148.0
DKPIVVHCSGGCGRTGTYIAmCLLIdqlKAEGLVdVFQVVRGLRLQRPGMVRS
.. . |||  | ||||| .| | |.   | ..|    . .  .| .||| | .
neavsvhcllgrgrtgtmla.cylv...kerkla.aaeaiaevrrlrpgsvet
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 92-185 6e-06 19.1 In-house 203-295 (346) alignment 
Range on Protein: 92-185
Range on HMM: 203-295/346.0
SSQHVKQFQYVSWPSKGVPDSAIGLLDVREQVEK--WQRDSGdkpIVVHCSGGCGRTGTYIAMCLLIDQLKAEGLVDVFQVVRGLRLQRPGMVRSV
 |  ..  ..  |     |  .. .. .  |       .. |   . |    ||||. ..|     |.||      ....... .. |||| | | 
dsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnag...vcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesf
subfamily_Tensin_pd Subfamily Tensin 97-152 6.8e-06 18.7 In-house 70-124 (189) alignment 
Range on Protein: 97-152
Range on HMM: 70-124/189.0
KQFQYVSWPSKGVPdSAIGLLDVREQVEKWQRDSGDKPIVVHCSGGCGRTGTYIAM
|. . . ||..  | |   |  . .....| .   .. .|||| || ||.|  .. 
kkvldfGWPdllaP.sleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsa