Gene PTPRD-78 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP137_AA protein Get Run
AqueP137_AA_1228-1501 phosphatase_domain Get Run
AqueP137_AA_1534-1803 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1223-1528 6e-130 429.5 In-house 2-309 (564) alignment 
Range on Protein: 1223-1528
Range on HMM: 2-309/564.0
RQSISVSMFPDYVKRLHANTDHLFSEEYELITIKsPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPL
...|.|. ....|..|.|| |  |.|||. |. . .. . ||... .| .|||| ||  .|..||||.|..| ||||||||..|||| .| .||| ||||
skpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

AETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKI-NNKDDESFEVKQFHYTAWPDFGVPDHPNPII
|||  |||||.|||..|.|||||...|||. |||.|||..|..|.||||||. ... ||.|.|||||. ..|..|| ||.|||.|.||| |||.......
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

SFIRRVNNS--THTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPKEAKIL
..||.|...  ...||.||||||||||.||||.|..|.  ...|..||....|  .|..||.||||| ||.|.|. ..| .. || | ...|. .. . |
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

LTTQEDNNI
 ...||...
aeveedtem
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1226-1524 3.7e-111 366.2 In-house 2-304 (318) alignment 
Range on Protein: 1226-1524
Range on HMM: 2-304/318.0
ISVSMFPDYVKRLHANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAET
|||. . . |.||... . |.||||| .. .. .  .  | . .|  |||| || ..|.||| |... | |||||||||||||| .. .|||.|.||.||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

SPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINNK-DDESFEVKQFHYTAWPDFGVPDHPNPIISFI
 .|||||.|||... |||||...|.|. |.|.|||. ||...|.|.|.. ..  |..|..|.||....  .|| .|.|.|||.||| |||...  .....
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RRVNNST---HTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPKEAKILLT
|.|..      .||.|||||||||| |.|||.....  .. |. ||||..|  .|..|| ||||| || |..| |.| .. |..|   ... .. . |  
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

TQE
.. 
qdp
subfamily_PTPRB_pd Subfamily PTPRB 1222-1507 4.3e-109 359.1 In-house 3-292 (293) alignment 
Range on Protein: 1222-1507
Range on HMM: 3-292/293.0
QRQSISVSMFPDYVKRLHANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGP
. . |....| ..||...|..|. |||||| .     .  ..|.....| .|||| || ..|..|| |... . .||||||||||.|| |.  .||.|||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

LAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQT-GSTTFGELTVTIIDQQVLAYYTIRTFKINNkDDESFEVKQFHYTAWPDFGVPDHPNPI
| ||  |||||.||.|.| |||||..||||. ||..|||..  ....|...||.. ...|  ..||..||.. ..|. .|.|.|.|.|||.|||......
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktl

ISFIRRVNNST----HTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQ
..|.|.|....    ...|.||||||||||.|||||.. ..  .|.|  ||.| .| ..|..||..||||.||.|.|.....|.. ...|.
ldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkeeek
0051299 (Phosphotyrosine protein) phosphatases II 1225-1500 3.6e-105 346.8 In-house 4-286 (288) alignment 
Range on Protein: 1225-1500
Range on HMM: 4-286/288.0
SISVSMFPDYVKRLHANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAE
.|||. . ..|..|.||  ... ||.| .. . |.|.  |..  .|.||||| .|  .| .||.|. ..|.||||||||.||||| .  ..||.|||| .
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINN-----KDDESFEVKQFHYTAWPDFGVPDHPNP
|  |||||.|||....|||||..||.|| ||.||||. ||.|.|..|||... .||..||.||... |     .|.||..|..||||.|||.||||.|..
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

IISFIRRVNNS--THTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
...|.|.|...   . || ||||||||||.|||||.  .. ..|.||.|||...|  .|..|..||||. ||.||.. |.|..
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRG_pd Subfamily PTPRG 1226-1511 9.6e-105 345.9 In-house 1-298 (563) alignment 
Range on Protein: 1226-1511
Range on HMM: 1-298/563.0
ISVSMFPDYVKRLHANTDHLFSEEYE--LITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGS-DYINANYIDGYGSRDTYIACQGPL
. |. |  .|  |||..|. ||||.|    ...| .|. |.||...| .|||| || ..|..|| |...||.... |||||||||||   . .|| ||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

AETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINN------KD-DESFEVKQFHYTAWPDFGVPD
..|  |||||||||... |||.|| ||.|| ||..|||. .| |.|.|.||.|...|||.||.||..|.|      |. |.  .|.|.||| ||| |||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HPNPIISFIRRVNNSTHT--GPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQN
|. | ..|... . ....  ||.||||||||||.||.|......  ...| .|.||.|.  .| .||..|||| ||.|.|| |.|.|. .. | . ..
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq
0050432 (Phosphotyrosine protein) phosphatases II 1237-1502 5.3e-102 336.5 In-house 35-301 (308) alignment 
Range on Protein: 1237-1502
Range on HMM: 35-301/308.0
RLHANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLtkipGiEGSDYINANYIDGY--GSRDTYIACQGPLAETSPDFWRMIW
  .|.  .|..||.| .. . |.|. ..... .|..|||| .|  .| .||.|    . ||||||||.|.|||  ... ..||.|||| .|  |||||.|
lekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

EQKTSCIVMLTNCVEKGRPKCHQYWPQT---GSTTFGELTVTIIDQQVLAYYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNS
||....|||||..||.||.||.|||| .   ||...| .|||.....||..||.||... | .|.||..|..||||.|||.|||..|.....|...|..|
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

THTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKV
   || ||||||||||.|||||.  .. ..|.||.||||. |  .|..|..||||. ||.|... |.|..| 
lpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1223-1520 6.9e-102 335.8 In-house 2-303 (319) alignment 
Range on Protein: 1223-1520
Range on HMM: 2-303/319.0
RQSISVSMFPDYVKRLHANTDHLFSEEYELITIKSPSlPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPL
.. | |  . ...|.|......|. .|..|. . ..    . ...  | .|||| || ..| |||||....|.||||||||..||||  |. .|| |.||
dteievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPl

AETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINNKDDES--FEVKQFHYTAWPDFGVPDHPNPI
..|  |||||.||...|..||||. |||.. |...|||..  ...|.|.||. ... |. | || .|.|.| .|    |||.|.||.||| .||..   .
entiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsl

ISFIRRVNNSTHT---GPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPKEAK
. ...|...|..    ||.|||||||||| ||||... |.  .. || .|||..|  .| .|| |||...|| |... |.| ...|..|  ||.. .  |
ldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlk

ILL
 | 
qla
0040438 (Phosphotyrosine protein) phosphatases II 1231-1522 8.6e-102 335.9 In-house 5-298 (317) alignment 
Range on Protein: 1231-1522
Range on HMM: 5-298/317.0
FPDYVKRLHANTDHLFSEEYELITIKSPSlPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFW
.......|...  ....||.| .   ... . . ..  .|..|||| .|  .| .||.|. ..|...||||||.|.||.  ....||.|||| .|  |||
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNN
||.|||....|||||...|.||.||.||||. ...|.|..|||... ..||..|.||... . .|.||..|..||||.|||.|||..|.....|...|..
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

S--THTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPKEAKILLTT
.   . ||..|||||||||.|||||.  |. ..|.||.|||.. |  .|..|...|||..||.|..| | |..| ..    ....... . ||..
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllip
0046845 (Phosphotyrosine protein) phosphatases II 1246-1502 2e-97 321.3 In-house 2-276 (284) alignment 
Range on Protein: 1246-1502
Range on HMM: 2-276/284.0
FSEEYELITIKSPSL--PHEASQQTCNIEKNRYGNINSFDETRVVLTKIPG-IEGSDYINANYIDGY-----GSRDTYIACQGPLAETSPDFWRMIWEQK
. ||.| ..   ..|  . ....  .|..|||| .|  .| .||.|. ..| .|.||||||.|.|||      .. ..||.|||| .|  |||||.|||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TSCIVMLTNCVEKGRPKCHQYWPQTG-STTFGELTVTIIDQQVLAYYTIRTFKINNK--DDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNS----
...|||||..||.|| ||.||||..| . |.|..|||... .|  .||.||... |.  ..||..|..||||.|||.|||..|.....|.| |...    
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

THTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEG---KVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKV
   || ||||||||||.|||||.  .. ..|.||   .|||.. |  .| .|..||||..||.||.. |.|..| 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0039614 (Phosphotyrosine protein) phosphatases II 1223-1502 8.3e-97 319.5 In-house 11-291 (297) alignment 
Range on Protein: 1223-1502
Range on HMM: 11-291/297.0
RQSISVSMFPDYVKRLHANTDHLFSEEYELITIKSPSlpHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGI-EGSDYINANYIDGYGS-RDTYIACQG
  .|..|... ......||  .|. .|.| .    |.   . ..  .|..|||| .|  .| .||.|. ..|  ..||||||.|.|||    ...||.||
sipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRpKCHQYWPQTGStTFGELTVTIIDQQVLAYYTIRTFKINNkDDESFEVKQFHYTAWPDFGVPDHPNPI
|| ||  |||||.|||....|||||..||.|| ||.||||..|. |.|..||| .. ..|..||.||... | ..||..|..|.|| |||.|||.... .
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslell

ISFIRRVNNST----HTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKV
..|.. |..        || .|||||||||.|||||.  |. ..|.||.|||.. |  .| .|...|||. ||.|..| |.||.| 
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0036941 (Phosphotyrosine protein) phosphatases II 1236-1507 9e-97 319.2 In-house 5-284 (297) alignment 
Range on Protein: 1236-1507
Range on HMM: 5-284/297.0
KRLHANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLtkiPGiEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWE
.  ...  .|...|.| ..   .. . ....  .|.||||| .|  .| |||.|   .. ||||||||.|.|||.   ..||.|||| .|  |||||.||
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

QKTSCIVMLTNCVEKGRPKCHQYWPQT--GSTTFGELTVTIIDQQV--LAYYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNS
|....|||||..||.||.||.|||| .  .| |.|..||| .. .|  |..||.||... . ...||..|..|||| |||.|||..|.....||..|.. 
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

T----HTGPLVVHCSAGVGRSGTFIAIQSMMLMME---TEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQ
       || .|||||||||||||||.  |. ..|   .||.||....|. .|..|. .|||. ||.|... | ||.| ..   
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
subfamily_PTPRA_pd Subfamily PTPRA 1224-1517 6.6e-96 316.0 In-house 12-312 (330) alignment 
Range on Protein: 1224-1517
Range on HMM: 12-312/330.0
QSISVSMFPDYVKRLHANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLA
  . |  . . ...  |.  .|| ||.. .   .     |....  | ||||. ||  .| .||.|... |.| |||||| .||||  .|..||.|||..
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

ETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINNKDD-----ESFEVKQFHYTAWPDFGVPDHPN
||  ||||||||||.. |||||.  |. . ||.||||. |. |.|...|.. |..||  ||.| | .... |     .|  |.|||.|.|||.||| .| 
etvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepi

PIISFIRRVN--NSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPKEA
 .......|.  |  ..||.||||||||||.||||...... ....|.|||||.||  .| .|  ||||. || |..  | |    |..|  |  . |  
GmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhl

K
.
q
0047943 (Phosphotyrosine protein) phosphatases II 1239-1500 8.9e-96 315.8 In-house 7-272 (273) alignment 
Range on Protein: 1239-1500
Range on HMM: 7-272/273.0
HANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLtkipGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKT
...  .|. ||.||..   |.|. ....  .|..|||| .|  .| .||.|    | .|||||||.|.||| .  ..||.|||| .|  |||||.|||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

SCIVMLTNCVEKGRPKCHQYWPQTG---STTFGELTVTIIDQQVLAYYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNN----S
..|||||..||.||.||.||||..|   |.|.|..|||...... ..||.||... | ...||..|..|||| |||.|||........||. |..    .
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

THTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
 . || ||||||||||.|||||.  .. ..|.||.|||.. |  .| .| .||||. ||.|... |.|..
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 1226-1500 1e-94 312.4 In-house 2-277 (278) alignment 
Range on Protein: 1226-1500
Range on HMM: 2-277/278.0
ISVSMFPDYVKRLHANTDHLFSEEYELITIKSPsLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAET
|||. .......|..|  .|...|.| ..   .  . . ..  .|..|||| .|  .| .||.|. ..| ..||||||.|.|||   ...||.|||| ||
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

SPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPqTGSTTFGELTVTIIDQQVLAYYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISFI
  |||||.||.....|||||..||.||.||.||||  ||.|.|..||| .....|..||.||... | .|.||..| ..||..|||.|||........|.
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

RRVNNS--THTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
..|..   .  ||..|||||||||.|||||.  .. ..|.||.||... | ..|..|  .|||. ||.|... | |..
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 1226-1516 1.2e-93 308.6 In-house 4-302 (307) alignment 
Range on Protein: 1226-1516
Range on HMM: 4-302/307.0
ISVSMFPDYVKRLHANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAET
|..   .. .|  . .||... .||| .  .  ..  ..|..  |  |||| .| .||.|||.|.||.| | ||||||..| ||  . ..|| |.|. .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

SPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINNKD------DESFEVKQFHYTAWPDFGVPDHPNP
  ||||||.||.   ||||.|  || | ||..|||.   . .|.. |......   .|.||.... .|.      ..| .| |.|||.|.|. ||.... 
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

IISFIRRVNN--STHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPKEA
.. .|..|..  ... .|.||||||||||||.|.|..|..  ...| |||.|..| |.|..|| .||  .||.|.. .|.. .. |.....|... .. 
llklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledai
0045450 (Phosphotyrosine protein) phosphatases II 1222-1500 1.9e-93 308.8 In-house 5-304 (307) alignment 
Range on Protein: 1222-1500
Range on HMM: 5-304/307.0
QRQSISVSMFPDYVKRLHANTDHLFSEEYELITIKSP--SLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGI-EGSDYINANYI--------DGYG
  . |.. ..  .|..|...  ... .|.| .    .  . ......  .|..|||| .|  .| |||.|. ..|  |.||||||.|.        ||| 
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

SRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGST-TFGELTVTIIDQQVLAYYTIRTFKINN--KDDESFEVKQFHYTA
. ...||.|||| ||  |||||.|||....|||||..||.||.||.||||..|.. |.|..||| .. ..|..||.||... .  ...||..|..||||.
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPDFGVPDHPNPIISFIRRVNN----STHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGK---VDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
|||.|||........||..|..    ..  || .|||||||||.|||||.  |. ..|.||.   ||... |  .| .|  .||.. ||.|... | ||.
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPRD_pd Subfamily PTPRD 1548-1808 4.3e-93 307.9 In-house 29-287 (564) alignment 
Range on Protein: 1548-1808
Range on HMM: 29-287/564.0
LNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVED
 ..|.    ..  .|. |.|.||||| .|..|.. ||.| ...|..||||||||..||| . ...| |||||..|..|||||.||...| ||||  |.| 
ykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEk

GKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITItHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHhLFGGGPVVVHDSSSVG
||..  .|||... ..||.. ..  .|..   |.||.... ..|. .|.|...|||.|.| ..  | .. .|.|.|  |....   . ||.||| |. ||
gkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVG

RSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFDKY
|.|||..|....||.| |...||. ...|||.. . .| . .|. |....|.|.|..... 
RTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1233-1501 1.1e-92 305.2 In-house 10-280 (288) alignment 
Range on Protein: 1233-1501
Range on HMM: 10-280/288.0
DYVKRLHANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRM
..|.. .|..   |||||. ..    .  ..|.... | .|||| || ..||.|| |.| .  .|.|||||.||||.... .||| |||||.|  |||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGS-TTFGELTVTIIDQQVLAYYTIRTFKINnKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNN--
..|.||| |||||. ||.|. ||..|||...  . .|..|||..... |  .. |.. .. |. . .|..|..|.|||| |||.  .|.. ..| |..  
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskapllellrqvkvan

STHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
.  |||..|||||||||.|||||.. .. ..|.| ..||...|  .|..|. .|||. ||.|... |..||.
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie
DSPc_SM00195 1246-1501 3.4e-91 300.6 In-house 2-263 (263) alignment 
Range on Protein: 1246-1501
Range on HMM: 2-263/263.0
FSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLT
..||.| .  . .. . . ...  | .|||| ||  .|.||| |.|... |||||||||||.|. .. .|||.|||| .|  |||||.||.|...|||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NCVEKGRPKCHQYWPQT--GSTTFGELTVTIIDQQVLA-YYTIRTFKINNKDD-ESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSTH--TGPLVVH
...|.|. ||..|||..  |..|||...|......     ...||........ |...|.|..|..||| ||||.........| |..|.   .||.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
|||||||.|||..|....  .|.| |||.|. |  .|..|  ||||..||.|... ..|.||
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 1246-1501 3.4e-91 300.6 In-house 2-263 (263) alignment 
Range on Protein: 1246-1501
Range on HMM: 2-263/263.0
FSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLT
..||.| .  . .. . . ...  | .|||| ||  .|.||| |.|... |||||||||||.|. .. .|||.|||| .|  |||||.||.|...|||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NCVEKGRPKCHQYWPQT--GSTTFGELTVTIIDQQVLA-YYTIRTFKINNKDD-ESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSTH--TGPLVVH
...|.|. ||..|||..  |..|||...|......     ...||........ |...|.|..|..||| ||||.........| |..|.   .||.|||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
|||||||.|||..|....  .|.| |||.|. |  .|..|  ||||..||.|... ..|.||
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1543-1810 2.8e-90 297.6 In-house 24-288 (318) alignment 
Range on Protein: 1543-1810
Range on HMM: 24-288/318.0
KQFEKLNSIDvAIPSQYISaSLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLC
...|.|.  . . .... |   |||.||||| .||.|.. ||.| || |. |||||||.|.||| | ...| .|.||..|..|||||.||   . |||| 
eeyerlsrse.etvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmlt

GLVEDGKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITHTKQgNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGGPVVVHD
 ..| ||..  .|||... ..||.. .|  .|.... ||.||...|.|.. .|.|...|.|||.|... .|  .. |.|..  |.||..  | ||.||| 
qeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrtee.eesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhC

SSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFDKYAN
|. ||| |.|....|..||.| |...|.| |.. ||.. . .|   ||..|.|....|.|.|.|....
saGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1225-1512 3.4e-90 297.3 In-house 3-295 (305) alignment 
Range on Protein: 1225-1512
Range on HMM: 3-295/305.0
SISVSMFPDYVKRLHANTDHLFSEEYELITIKspSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAE
 |... .  |.|  ....|. . ..|.... .  . . .  ... | .|||. .|. .|. |. ||. .  . ||||||.|.||| ....||. |||| .
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGST--TFGELTVTIIDQQVLAYYTIRTFKINN--KDDESFEVKQFHYTAWPDFGVPDHPNPI
|  ||||.|.| |.| |||||. || |. ||.||||.. .    |||..|.. ...  . |..| .|| .  .|.||  | |.. | ||| |||. .  .
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

ISFIRRVNNSTHTG---PLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNF
.|.|.||... . .   ||.|||||||||.|.|||.. ..  ...|. ||||. .  .|.|| .|||| .||.|.|| | |||. |. .  ..|.
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl
0051299 (Phosphotyrosine protein) phosphatases II 1540-1802 1.6e-89 295.4 In-house 24-286 (288) alignment 
Range on Protein: 1540-1802
Range on HMM: 24-286/288.0
PLPKQFEKLNSIDVAipSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIV
 | ..||.| |. .    .. .|.|| |. ||||.|||||.. ||.| .|.||.|||||||||.||| . ..||.|||||.|||.|||||.||..|. ||
glleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIv

MLCGLVEDGKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITHTK---QGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlFGGG
||..|||.|. .. |||| .. ..|||......||.  . |..|....|...   ...|.|....||||.| .. .|... .|.|.. ||.||.   |||
mltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sggg

PVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
||||| |  |||.|||... ...|.|. ||..|.. ... ||.. ||.| . .|..|.|....|||
pvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1232-1506 2.3e-89 294.6 In-house 15-296 (298) alignment 
Range on Protein: 1232-1506
Range on HMM: 15-296/298.0
PDYVKRLHANTDHLFSEEYELITIKSPS---LPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPD
. ...  ....   ...|.. ..  | .     .|..... | .|||| .| ..| .||||.|. . | |||||| ....|  |...||.|.|| ||  |
qklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetved

FWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINNKD-DESFEVKQFHYTAWPDFGVPDHPNPIISFIRRV
||||..|.. ..|||||| .|... |.|.|||..|..|.||.||..  ... | ...|..|...|. ... ||.|.|.| ||| ||| . . .. ..|.|
FWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkv

NNST-HTG--PLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSE
. |. ..|  |..|.||||||||||||||.|..  ...| .||||. |  .|.||  .||||.||.|...   | .. .| |
rasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
0040439 (Phosphotyrosine protein) phosphatases II 1263-1500 2.6e-88 291.1 In-house 4-246 (249) alignment 
Range on Protein: 1263-1500
Range on HMM: 4-246/249.0
EASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQT
. ..  .|..|||| .|  .| .||.|. .|| ..||||||.||||| . ...||.|||| || .|||||.||.. ..|||||..||.|| ||.||||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GSTTFGELTVTIIDQQVLAYYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNST----HTGPLVVHCSAGVGRSGTFIAIQSMM
||...|..||| .. .|...||.||... | .|.||..|....|| |||.|||........||..|..        ||..|||||||||.|||||.  |.
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

LMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
 ..|.|..||... | ..|..|...||.. ||.|... | ||.
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0050432 (Phosphotyrosine protein) phosphatases II 1540-1810 3.7e-88 291.1 In-house 43-307 (308) alignment 
Range on Protein: 1540-1810
Range on HMM: 43-307/308.0
PLPKQFEKLNSIDVaiPSQYISASLPVNRAKNRYPDILPYESYRVRLlmlpGvSGSDYINASYVDGY--LRCNQFIMTQGPLSNTVDDFWRMIWEHRVSA
 | ..||.|.|. .  . .| .|.|| |. ||||.|||||.. ||.|    . .|||||||||||||   . ..||.|||||.|||.|||||.||..|. 
lleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVMLCGLVEDGKDQSVQYWPKD---QLTQYGDMFIETISETDTGFYVIREITITHTKQGnEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHhlfG
||||. |||.|. .  |||| .   . ..||.......||.  . |..|....|... | |.| ...||||.| . ..|| . .|.|.. ||.| .   .
IvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl...p

GGPVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFDKYAN
|||.||| |  |||.|||... ...|.|. ||..|.| ... ||.. || | ...|..|.|....|||... ...|
ggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkln
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1235-1501 1e-86 285.6 In-house 6-277 (281) alignment 
Range on Protein: 1235-1501
Range on HMM: 6-277/281.0
VKRLHANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIW
.|.|..| .. | |||| ..    . . .||..  |..|||| || ..| |||..|.    . .||||||...|| .   |||.|||. ..  .||.|.|
lkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvw

EQKTSCIVMLTNCVEKGRPKCHQYWPQTG-STTFGELTVTIIDQQVLAYYTIRTFKINNKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVN---NS
||| | |||.|. .|.|. |||.|||.   ....|..||. . ..  | |  |.||..... |. ||.|..|||||| |||. .. ...| . |.   ..
eqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltek

THTGPLVVHCSAGVGRSGTFIAIQSMMLMMETE-GKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
 .  |||.||||||||.||.||.  ..  .|.|  ..|| . | ..|..||.|||| .|| ||.  ... ..
ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0042113 (Phosphotyrosine protein) phosphatases II 1265-1500 1e-86 285.6 In-house 4-243 (245) alignment 
Range on Protein: 1265-1500
Range on HMM: 4-243/245.0
SQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGS
..  .|..|||| .|  .| |||.|. ..| ..||||||.|.|||   ...||.||||.|| .|||||.||.. ..|||||...|.||.||.||||. .|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

TTFGELTVTIIDQQVLAYYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNN---STHTGPLVVHCSAGVGRSGTFIAIQSMMLMM
.|.|..||| .. ..|..||.||... | .||||.|| ..||. |||.||||... ...|...|..   ..  ||..|||||||||.|||||.  |. ..
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

ETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
|.|..|.... | ..| .|  .|||. ||.|... | ||.
ekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 1270-1497 1.5e-86 285.0 Pfam-A 1-234 (235) alignment 
Range on Protein: 1270-1497
Range on HMM: 1-234/235.0
NIEKNRYGNINSFDETRVVLtkiPGIEG-SDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWP--QTGSTT
| .|||| .|  .|.||| |    | || ||||||||..|| .  ..||.|||| .|  |||||.|..|...|||||...|||| ||.||||  . .|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGELTVTII-DQQ-VLAYYTIRTFKINNKDDES--FEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNST--HTGPLVVHCSAGVGRSGTFIAIQSMMLMM
.|...|..  ...   . ||.|......|..||  .||||.|||.||| |||..|......||.|..|.  ..||.||||||||||.|||.|.. .. ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

ETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLV
|.|..|||...|  .|..|. |||...||.|... ..
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1270-1497 1.5e-86 285.0 In-house 1-234 (235) alignment 
Range on Protein: 1270-1497
Range on HMM: 1-234/235.0
NIEKNRYGNINSFDETRVVLtkiPGIEG-SDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWP--QTGSTT
| .|||| .|  .|.||| |    | || ||||||||..|| .  ..||.|||| .|  |||||.|..|...|||||...|||| ||.||||  . .|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGELTVTII-DQQ-VLAYYTIRTFKINNKDDES--FEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNST--HTGPLVVHCSAGVGRSGTFIAIQSMMLMM
.|...|..  ...   . ||.|......|..||  .||||.|||.||| |||..|......||.|..|.  ..||.||||||||||.|||.|.. .. ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

ETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLV
|.|..|||...|  .|..|. |||...||.|... ..
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0046845 (Phosphotyrosine protein) phosphatases II 1541-1810 1.6e-86 285.5 In-house 2-282 (284) alignment 
Range on Protein: 1541-1810
Range on HMM: 2-282/284.0
LPKQFEKLNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGV-SGSDYINASYVDGY-----LRCNQFIMTQGPLSNTVDDFWRMIWEHR
| ..||.|.|. | .  ..  | || |. ||||.|||||.. ||.| .|.|  ..||||||||||||      ....||.|||||.|||.|||||.||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VSAIVMLCGLVEDGKDQSVQYWPKDQ-LTQYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHL-
|. ||||..|||.|. .  |||| ..   .|||......||.  . |..|....|... ..|.| ...||||.| ....||..  |.... ||....   
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

FGGGPVVVHDSSSVGRSGTFCIINIVIERLKVEG---MIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFDKYAN
 ||||.|||.|  |||.|||... ...|.|. ||   ..|.. ... ||.. || | ...|..|.|....||| .. ....
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
subfamily_PTPRK_pd Subfamily PTPRK 1235-1512 1.8e-86 284.8 In-house 13-289 (314) alignment 
Range on Protein: 1235-1512
Range on HMM: 13-289/314.0
VKRLHANTDHLFSEEYELITIKspslpHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIW
.. |...  . | |||| .         .|...  | ||||.|.| ..| .||.|. | |   ||||||..||.|     .|. |||| ||  ||||...
iallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvy

EQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTtFGELTVTIIDQQVLAYYTIRTFKINN---KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNST
......|||||. ||.|| || .|||. ... .|.. |.... ..|| . .|.|....   . .|  ||.||....|||..|| . . .....|||..|.
dencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksq

--HTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNF
  . |..||||||| ||.||||||.... |.|.|| ||||| | ..| ..  ||.|| ||.|..| ..|   .|..   | .|
eeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsef
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1548-1806 3.5e-86 284.2 In-house 29-287 (319) alignment 
Range on Protein: 1548-1806
Range on HMM: 29-287/319.0
LNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVED
 . .. | . .. ||| . |. ||||..||.|.  || |  |.|| ||||||||..||| . ..|| ||.||.||..|||||.||...| .|||..||| 
fkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklvek

GKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGGPVVVHDSSSVG
.| .  .|||. . ..|| . ..  .|  .  |.||.... . ..  | |..|.|.||.|.... | .. .|.|..  ..|...    ||.||| |  ||
lkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvG

RSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFD
| |||.......||.| ||..|.| |.  || . . .| . .|.||.|....|..|..|
RtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0045098 (Phosphotyrosine protein) phosphatases II 1245-1502 3.8e-85 280.9 In-house 8-274 (278) alignment 
Range on Protein: 1245-1502
Range on HMM: 8-274/278.0
LFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVltkipgiegsDYINANYIDGYgsRDTYIACQGPLAETSPDFWRMIWEQKTSCIVML
 .. |.| . . ..    . ..  .|..|||| .|  .| .||.          |||||.|||||  ....||.|||| .|  |||||.||.....||||
dlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivml

TNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINN-----KDDESFEVKQFHYTAWPDFGVPDHP--NPIISFIRRVNNST------
|..||.|| ||.||||  || |.|..|||... .|| .||.||... |     .|.||..|...||. |||.|||..|  ............        
telvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------HTGPLVVHCSAGVGRSGTFIAIQSMMLMMetEGKVDVFNFVLDMRHKRNY-MVQTEAQYMFVHDSLVELIKV
         . || .|||||||||.||..|.  |. ..  ||.||... |  .| .|.. .||.. ||.|... |.||.. 
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0047943 (Phosphotyrosine protein) phosphatases II 1541-1802 3.5e-84 277.8 In-house 14-272 (273) alignment 
Range on Protein: 1541-1802
Range on HMM: 14-272/273.0
LPKQFEKLNSIDVaiPSQYISASLPVNRAKNRYPDILPYESYRVRLlmlpGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVM
| ..||.| |. .  .  |  |.|| |. ||||.|||||.. ||.|    | .||||||||||||| . ..||.|||||.|||.|||||.||..|. |||
lleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

LCGLVEDGKDQSVQYWPKDQ---LTQYGDMFIETISETDTGFYVIREITITHTKQGNeVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLF-GGG
|. |||.|. .  |||| ..    ..||.......||.  . |..|....|... |. .| ...||||.| ....||..  |...| ||.||.. . ..|
LtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsng

PVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
||||| |  |||.|||... .....|. ||..|.. ... ||.. ||.| ...|..|.|....|||
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 1544-1805 8.1e-84 276.9 In-house 23-279 (317) alignment 
Range on Protein: 1544-1805
Range on HMM: 23-279/317.0
QFEKLNSIDVAipsQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCG
.||.| |...     |  |.||.|. ||||||||||.. ||.|  |.|. .|||||||||||. ....||.|||||.|||.|||||.||..|. ||||. 
efedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLte

LVEDGKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITHTkQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlFGGGPVVVHDS
|.|.|. .. |||| .. ..|||......||.  . ...|....... ...|.| ...||||.| . ..||..  | |.. .|..|    .||||.|| |
leelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCs

SSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESF
  |||.|||... ...|.|. || .|.. ... ||.. ||.| ...|..|.|. . |||  .
aGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0036941 (Phosphotyrosine protein) phosphatases II 1540-1805 1.9e-83 275.5 In-house 14-280 (297) alignment 
Range on Protein: 1540-1805
Range on HMM: 14-280/297.0
PLPKQFEKLnsIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLlmlpGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIV
 | |.||.|   .. ..  .  |.|| |. ||||.|||||.. ||.|    . .||||||||||||| ....||.|||||.|||.|||||.||..|. ||
lllkefeel..lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLCGLVEDGKDQSVQYWPKD--QLTQYGDMFIETISETD--TGFYVIREITITHTkQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLF-G
||. |||.|. .  |||| .  .  .|||......|..    . |..|....|.| ...|.| ...||||.| ....|...  |.|.| ||.|...|. .
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

GGPVVVHDSSSVGRSGTFCIINIVIERLK---VEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESF
||||.|| |  |||||||... .....|.    || .||. ... ||.. ||.| ...|..|.|... |.| ..
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1265-1516 3.2e-83 274.7 In-house 56-307 (319) alignment 
Range on Protein: 1265-1516
Range on HMM: 56-307/319.0
SQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTncvekgRPKCHQYWPQTGS
.    | .|||..|| .||...| | .. |.|.|||||| ...|| ..| |||.|||| .|  ||||||||...| ||.||      . || ||||. . 
anldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

TTFGELTVTIIDQQVLAYYTIRTFKINN--KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRV----NNSTHTGPLVVHCSAGVGRSGTFIAIQSMML
 . ..  | .   .  | |..| ... .  |  .  ...|||.  ||| ||||.| ... ....|    .   |  ..||||||||||.|..|... .. 
ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlld

MMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPKEA
.|. | .|||.||| |.| .|| .||  .||.|.. .|.|   .|.|. .. .||   
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayl
0039614 (Phosphotyrosine protein) phosphatases II 1543-1806 2.8e-82 271.8 In-house 36-293 (297) alignment 
Range on Protein: 1543-1806
Range on HMM: 36-293/297.0
KQFEKLNSIDVaiPsqYISASLPVNRAKNRYPDILPYESYRVRLLMLPGV-SGSDYINASYVDGYLR-CNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVM
..||.| |. .  .  |  | ||.|. ||||.|||||.. ||.| ...||  .|||||||||||| . ...||.|||||..||.|||||.||..|..|||
lefeellslkp..d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivm

LCGLVEDGKdQSVQYWPKDQLtQYGDMFIETISETDTGFYVIREITITHtkqGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLF-GGGPVV
|. |||.|. . .|||| ..  .|||.........  . |..|....|.   ..|.| ...|.||.| ....||..  |.... ||..|.    .||||.
Ltklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvl

VHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFD
|| |  |||.|||... ...|.|. || .|.. ... ||.. ||.| . .|..|.|. ..|.|  ..
VHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1269-1517 3.4e-82 271.1 In-house 24-272 (284) alignment 
Range on Protein: 1269-1517
Range on HMM: 24-272/284.0
CNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTncvekgRPKCHQYWPQTGSTTFG
 | .|||.|.| .||...| | .. |.|.|||||| .| || ..| |||.|||| .|  ||||||||...| ||.||      . || ||||. .  . .
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

ELTVTIIDQQVLAYYTIRTFKINN--KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRV----NNSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMET
.  | .   .  . |..| ... .  |  .  ...|||.  ||| ||||.| ... ....|    .   |  ..||||||||||.|..|... .. .|. 
rfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmke

EGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPKEAK
| .|||.||| |.| .|| .||  .||.|.. .|.|   .|.|. .. .||   .
ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayle
0045450 (Phosphotyrosine protein) phosphatases II 1535-1802 5.6e-82 271.2 In-house 23-304 (307) alignment 
Range on Protein: 1535-1802
Range on HMM: 23-304/307.0
VTALSPLPKQFEKLNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGV-SGSDYINASYV--------DGYLRCNQFIMTQGPLSNTVDD
 . |. | |.||||.|. | ..  | .|.||.|. ||||.|||||.. ||.|  |.|  ..|||||||||        ||| ....||.|||||..||.|
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKD-QLTQYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIV
||||.||..|..||||..|||.|. . .|||| . .  .||.......||.  . |..| ...|.... .|.| ...||||.| . ..||..  | |.| 
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

LVQKAHHLF-GGGPVVVHDSSSVGRSGTFCIINIVIERLKVEGM---IDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
.|.||..   .||||.|| |  |||.|||... .....|. ||.   .|.. ... ||.. ||.| |..|..|.|. . |.|
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 1265-1500 2.4e-81 268.1 In-house 5-242 (243) alignment 
Range on Protein: 1265-1500
Range on HMM: 5-242/243.0
SQQTCNIEKNRYGNINSFDETRVVLtkipgiEGSDYINANYIDGYgsrDTYIACQGPLAETSPD----FWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWP
..  .|..|||| .|  .| .||.|      |||||||||.|...   ...||.|||| ||  |    ||||.||.....|||||..||.|| ||.||||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

qtGSTTFGELTVTIIDQQVLAYYTIRTFKINN--KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVN----------NSTHTGPLVVHCSAGVGRSG
  |..|.|..|||......|..||.||... |   ||....| ..||..|||.||||.|.....|.. |.          .  . ||..|||||||||.|
..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TFIAIQSMMLMMetegKVDVFNFVLDMRHKRNY-MVQTEAQYMFVHDSLVELI
|.||.  |.|..    .||... | ..| .|.. .|||. ||.|... | ||.
tliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 1542-1802 3.4e-81 268.1 In-house 23-277 (278) alignment 
Range on Protein: 1542-1802
Range on HMM: 23-277/278.0
PKQFEKLNSIDVaipSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVML
 ..||.|.|...     |  | || |. ||||.|||||.. ||.| .|.|. .|||||||||||| ....||.|||||..||.|||||.||..|. ||||
llefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmL

CGLVEDGKDQSVQYWPkDQLTQYGDMFIETISETDTGFYVIREITITHTKQGNEvRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlFGGGPVVVH
..|||.|. ...|||| .. ..|||.......|.  . |..| ...|... |.. | . ..||..| ....|...  |.|..  |..| .   .|||.||
telvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVH

DSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
 |  |||.|||... ...|.|. || .|.. ... ||.. ||.| . .|..|.|. . |||
CsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1224-1507 7.9e-81 266.4 In-house 4-286 (315) alignment 
Range on Protein: 1224-1507
Range on HMM: 4-286/315.0
QSISVSMFPDYVKRLHANTDHLFSEEYELITIKsPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLA
| | .  .  || . .|.|   | ..|| |       | . .... | .|||| || ..|..|| |  .   ..|||.|||.||||  .. |||.|||..
qpipldqlityvaqkkastkngfkqdyesipgg.qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTgSTTFGELTVTIIDQQVLAYYTIRTFKINNKDdESFEVKQFHYTAWPDFGVPDHPNPIISF
..  ||||...|.. . |||||| ||. . |. .|||     ..|..||| ....|   ||.||. .  .| .  || |.|||.||| ||| .  |.. .
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgd.nirevvqlhytswpdmgvpkytiplmnl

IRRVN--NSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQ
||.|.  . .  |..||||||||||.||||......  .|.|  .||.||.  .|..|  |||. .|| |..| |.| . .|..  
irtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1265-1501 1.2e-80 265.4 In-house 4-243 (250) alignment 
Range on Protein: 1265-1501
Range on HMM: 4-243/250.0
SQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPkCHQYWPQTGS
...  | ||||| .| ..|..|||| |  | . |||||| ...||  |...|| |||| .|  |||||..|.|.. |||||| .|...  .|||||  ..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

TTFGELTVTIIDQQVLAYYTIRTFKINNKD-DESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSTHT---GPLVVHCSAGVGRSGTFIAIQSMMLMM
...|..||.. .... | ||.|..|. ..   ..  |.|.|...||| |||.. . .. ....|. |      .|..|.|||||||||.||||....  .
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

ETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
..| .||||...  .|..|  .|....||.||.  . . ..
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN12_pd Subfamily PTPN12 1260-1501 4.8e-80 263.5 In-house 30-278 (290) alignment 
Range on Protein: 1260-1501
Range on HMM: 30-278/290.0
LPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYW
 . ||.... |..|||| .|  .|..||.|.|| . |||||||||.| |  .. .||| ||||..|  ||||||||.... .||. . || |. ||..||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PQTGS--TTFGELTVTIIDQQVLA-YYTIRTFKINNKdDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNS--THTGPLVVHCSAGVGRSGTFIAIQ
|..|   ..|||..|| .... .   ..|||.|.... .|| .|.||||||||| |||  .......|. |..   ..  |||||||||||| || |||.
peegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaid

SMMLMMETE---GKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
 .  ....|    ..|||. ||..|..|. .|||. || .|. ...||..
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN9_pd Subfamily PTPN9 1239-1500 5.8e-80 263.5 In-house 11-290 (297) alignment 
Range on Protein: 1239-1500
Range on HMM: 11-290/297.0
HANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKT
...  .  |.||. |  ....   .||.. .|.||||| ..  .|||||||.|... | |||||||..|||  ....|| |||| .|. |||||.|||..
kekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqev

SCIVMLTNCVEKGRPKCHQYWP--QTGSTTFGELTVTIIDQQVLAYYTIRTFKIN-NKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNS-----
  ||| | .||.|| || ||||  .  |. ||.|.|. .....   |..|...|.  |..|| .|  | ...|||.|||.  . .. ... | .      
lvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalav

----------THTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
          ..  |.|||||||.||.||||..   .  .|..|.|||.. |  .| .| ...||. ||.| . ...|  
kelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1535-1809 1.3e-79 262.5 In-house 23-297 (298) alignment 
Range on Protein: 1535-1809
Range on HMM: 23-297/298.0
VTALSPLPKQFEKLNSIDVAIPSQ-YISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEH
 . |. . ..|..|||.   |... .  |. | |. ||||.||....| ||.|    .   |||||||....| . | ||.||.|| .|| |||||..|.
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvtee

RVSAIVMLCGLVEDGKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITHTKQGnEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLF
 ...||||  |.| .| .  .|||... ..||.. ..  |. . . ...|.......|.  . |...|.|.| |... .| .. ...|..  |.. ..  
digtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqa

GGGPVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFDKYA
|  ||.|. |. |||||||..|. |.||.| | ..|.| ....||.| ||.|   .|..|.|. . |.|.||. ..
gnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_PTPN6_pd Subfamily PTPN6 1245-1504 1.2e-77 255.9 In-house 27-301 (306) alignment 
Range on Protein: 1245-1504
Range on HMM: 27-301/306.0
LFSEEYELITIK--SPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTkIPGIEGSDYINANYID--GYGSRDTYIACQGPLAETSPDFWRMIWEQKTSC
 |.||.| .  .  .  | .. .... | ||||| ||  ||.|||.|.  |.. ||||||||||.    ||. .||| || | .| .|||||.|....  
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMLTNCVEKGRPKCHQYWPQTGS-TTFGELTVTIIDQQVLAYYTIRTFKIN--NKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNST------
|||.|. ||.|. || .|||.. . ...|...|| .... ||.|..|.....  .|..|. || |.|...||| ||| .|. ...|.. ||. .      
ivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea

HTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEG---KVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGN
..||.|||||||.|| |||| |  .. ..|..|   ..|. ..|  .|. |. .||||.|| ||. .. . |.  .
eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1565-1806 6e-77 253.8 In-house 44-287 (305) alignment 
Range on Protein: 1565-1806
Range on HMM: 44-287/305.0
PVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQLT--
 .|.||||. .| ...  |..|   . .  |||||||||||| | ...|..|||| |||.||||.|.| .|| ||||..|||.|||.  ||||. .    
eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekk

QYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGGPVVVHDSSSVGRSGTFCIINIVIERL
..|.. .|  ||. .  |..|...|.  .. .| |.. |.. ||| ..  | ....|...|  |||...   | |..|| | .|||.|.|. ..| .|||
efgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerl

KVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFD
| |...|.|  ...||.|....| . ||. |... . |.....|
kkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_PTPN3_pd Subfamily PTPN3 1249-1499 7.4e-77 253.0 In-house 20-274 (280) alignment 
Range on Protein: 1249-1499
Range on HMM: 20-274/280.0
EYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPgieGsDYINANYID----GYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVML
..| .  | |.|  .|.... |..|||| .| ..|.||| |.. .     |||||||..    . |    |||.|||||.|. |||.|.||||.| ||||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TNCVEKGRPKCHQYWPQTG-STTFGELTVTIIDQQVLAYYTIRTFKINNKD-DESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNST--HTGPLVVHC
|. ||.|| |||||||.|. ....||..|..  ..    | .| . ...|. .|. .. |. |.|||| ||||... ...|..||..    .. |.||||
ttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

SAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVEL
|||.||.| .|...  . ..|.. .| . . |  || .|  .|||..|| || ......
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
0040439 (Phosphotyrosine protein) phosphatases II 1559-1802 9.1e-77 253.3 In-house 3-246 (249) alignment 
Range on Protein: 1559-1802
Range on HMM: 3-246/249.0
YISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPK
|  |.||.|. ||||||||||.. ||.|  |||. .||||||||.||| ....||.|||||..||.|||||.||.....||||. ||| |. .  |||| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

DQLTQYGDMFIETISETDTGFYVIREITITHTkQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLF-GGGPVVVHDSSSVGRSGTFCIINI
.. ..|||......|..  . |..|....|.. . .|.| .....|||| . ..||..  |.|.| .|.||..    ||||.|| |  |||.|||... .
ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

VIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
..|.|. |. .|.. ... ||.. ||.| |..|..|.|. . |.|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
DSPc_SM00195 1543-1802 2.6e-75 248.5 In-house 4-262 (263) alignment 
Range on Protein: 1543-1802
Range on HMM: 4-262/263.0
KQFEKLNSIDVAIpsQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLC
..||||.. .     .  .|  . |..|||| .||||.. ||.|   .. .|||||||.|..|. . ...|.|||||..||.|||||.||..|. ||||.
eefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

GLVEDGKDQSVQYWPKD--QLTQYGDMFIETISETDTG-FYVIREITITHTKQgNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFgGGPVV
  .|.|| .  .|||..  . ...|.. ....... .   ...|....|.... .| |...|..|..| ....| .|  .....  |.| .     ||.|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
|| |  |||.|||. |.|....|. | ..||| .. .|| . ||.| . .|..|.|..|.||.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1543-1802 2.6e-75 248.5 In-house 4-262 (263) alignment 
Range on Protein: 1543-1802
Range on HMM: 4-262/263.0
KQFEKLNSIDVAIpsQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLC
..||||.. .     .  .|  . |..|||| .||||.. ||.|   .. .|||||||.|..|. . ...|.|||||..||.|||||.||..|. ||||.
eefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

GLVEDGKDQSVQYWPKD--QLTQYGDMFIETISETDTG-FYVIREITITHTKQgNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFgGGPVV
  .|.|| .  .|||..  . ...|.. ....... .   ...|....|.... .| |...|..|..| ....| .|  .....  |.| .     ||.|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
|| |  |||.|||. |.|....|. | ..||| .. .|| . ||.| . .|..|.|..|.||.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1230-1526 3.6e-75 248.1 In-house 6-305 (439) alignment 
Range on Protein: 1230-1526
Range on HMM: 6-305/439.0
MFPDYVKRLHANTDHLFSEEYELITIKSPSLPHEASQ--QTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSP
 | ..|..|. | . .|.|..| |   ||    .||   |  .  |||| .. .|| |||.| .|||.  | |||||||.||   . |||.|||  ||. 
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMIWEQKTSCIVMLTNCVEKGRpkchqYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINNKDDES---FEVKQFHYTAWPDFGVPDHPNPIISFI
||||...|.||. |||||| ||  .     |||  . . .|...| .  .  |  |.|| ||. |. | .     | ||||.||||  || .   .. |.
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

RRV---NNSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPKEAKILLT
| .   |..  .||.||||||||||.|| ||..  .  . .| |||.   |  .|..|. |||. .||.|......| |. |.   |...| || .  ..
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkefnagfs

TQEDN
|.. .
trdis
subfamily_PTPRA_pd Subfamily PTPRA 1546-1802 4.1e-75 247.7 In-house 36-295 (330) alignment 
Range on Protein: 1546-1802
Range on HMM: 36-295/330.0
EKLNSIDV-AIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGL
|..|..    | . .  ||   |. |||...||||.  || | .. ||  |||||||..||| . ..|| .|||...||.||||||||.. ..||||  |
eefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltel

VEDGKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITIT---HTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGgPVVVH
 |  ...  ||||.. |  ||.. .|   || .  | .|.. ..   .... ...| ..|||.| | .   | ..  .....  |.| ..  .| |.|||
kerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvh

DSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
 |. |||.|||.... |.||.| |...|.| ... || . | .|    |..|.|... || 
csaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPRG_pd Subfamily PTPRG 1541-1805 7.2e-75 247.3 In-house 21-290 (563) alignment 
Range on Protein: 1541-1805
Range on HMM: 21-290/563.0
LPKQFEKLNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGS-DYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIV
. ..||.|.|  ..   .. ... | |. |||| .|..|.. ||.|  |||. .. |||||.|.||| . ..||.||||| .|.|||||||||..|. ||
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv

MLCGLVEDGKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITH-----TKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQkAHHLFG
|.  |||.|. .  .|||||.  .|| . .  |.|  .  | .|...| .     .|| .......|.|||.| .  .|  .   . ...  . | .   
mitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkss.aankae

GGPVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESF
 ||.|||.|. |||.||..... ...... | ....| ... .| . . .|.. .|. | .....| . | 
aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
0045098 (Phosphotyrosine protein) phosphatases II 1545-1805 1e-74 246.7 In-house 11-275 (278) alignment 
Range on Protein: 1545-1805
Range on HMM: 11-275/278.0
FEKLNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRllmlpgvsgsDYINASYVDGYlRcNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGL
 |  . .   |||..  | .. |..||||.|||||.. ||.          |||||||.||| . ..||.||||| .||.|||||.||.....||||..|
lefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.p.kkfIatqgPlpstvadfwrmlwelgitvivmltel

VEDGKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITHT---KQGNEVRNIKQFHYTDWSENKTPPTT--GALMDMIVLVQKAHH--------
||.|.   .|||| ..  .|||......||. .. |..| ...|..   ....| |.....||. | .. .|...    . ...  ...|.         
velgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

----LFGGGPVVVHDSSSVGRSGTFCIINIVIERLkvEGMIDIFFTIHALRRKHPG-IVANYDQFKFCYQTIVEYLESF
    | .||||.|| |  |||.||.... ...|.|  || .|.. ... ||.. || .| | .|..|.|. ..|.|. .
slllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0042113 (Phosphotyrosine protein) phosphatases II 1562-1803 2.5e-74 245.1 In-house 4-244 (245) alignment 
Range on Protein: 1562-1803
Range on HMM: 4-244/245.0
ASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQL
|.||.|. ||||.|||||.. ||.|   .|  .|||||||||||| ....||.|||||..||.|||||.||.....||||. ..|.|. .. |||| .. 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

TQYGDMFIETISETDTGFYVIREITITHtKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGGPVVVHDSSSVGRSGTFCIINIVIER
..|||......||.  . |..|....|. .. .|.|.. ..||..| ....|...  | |.. .|.|| .  ..|||.|| |  |||.|||... ...|.
ltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

LKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLE
|. |. .... ... ||.. ||.| . .|..|.|. . |.|.
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_Ptp69D_pd Subfamily Ptp69D 1543-1803 1.1e-73 243.0 In-house 26-287 (307) alignment 
Range on Protein: 1543-1803
Range on HMM: 26-287/307.0
KQFEKLNSIdvAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLC
| .|||..    |. .   .    |  ||||.|| .....||.|  ..|   |||||||.. ||   ..||. |.|. .|..||||||.|  |  |||| 
keyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmls

GLVEDGKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITHTK-QG---NEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFgGGPV
 | |  ...  .|||... .||||. ....||  .. |.|||. ....| ..   .. |.. |.||| | . | | .. .|...|  |.. ..|   .|.
nlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPi

VVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLE
||| |  |||||.|  .......|| |  .||| |.. ||.. . .| ...|..|.|. ...| .
vvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1225-1530 1.2e-73 243.1 In-house 4-315 (325) alignment 
Range on Protein: 1225-1530
Range on HMM: 4-315/325.0
SISVSMFPDYVKRLHANTDHLFSEEYELITIKSPSlPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAE
||.|  . ..|.. .|. .  |. |..|.  . .   .... .  |..|||. |. ..|..||||        ||||||.|.  .  .|...|.| ||..
siavvnlvehvekkkaqdqdgfahefgllpsddgi.akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPlta

TSPDFWRMIWEQKtSCIVMLTNCVEKGRPKCHQYWPQT--GSTTFGELTVTIIDQQVLAYYTIRTFKINNK-DDESFEVKQFHYTAWPDFGVPDHPNPII
|  |.||.. . . . .|...| ...|  .| .|||.    | ||| | | ..  . .. |  | ... .  . |.  ||||.. .|.|.||. .|  .|
tindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatli

SFIRRVN--------NSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFp
|... |.        |.  ..|..|||||||||.|.||.. |..  . .| .||.|.||  .|..|  ||.|  ||......||| .  ||..  | .| 
silqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssf.

kEAKiLLTTQEDNNIED
 ||| | . || | . .
.eak.lsslqernpltq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1227-1507 1.3e-73 242.9 In-house 3-283 (515) alignment 
Range on Protein: 1227-1507
Range on HMM: 3-283/515.0
SVSMFPDYVKRLHANTdhLFSEEYELITikSP-SLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAET
 .. || .|..    |  |||||.  .    |   |   .|.  | .||||.||  .| .|| |  |     |||.|| || .. .  .||| |||.  .
plaqfPafvnknrhtt..lfseefhdlp..gpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

SPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQ--TGSTTFGELTVTIIDQQVLAYYTIRTFKINNKDDeSFEVKQFHYTAWPDFGVPDHPNPIISF
  ||||........ |.|.|.  |  . || .|||.  . |  ||.. | ..  .  .  ..|....   || |  | |||.| ||| ||| | . .. .
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllkl

IRRVNNST--HTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQ
|. |  ..   | ||..|||||||| | .|.|.|..  ..|   |||||||  .| || |.|||. || |... . | ..  |.  
ikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntli
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1224-1521 1.5e-73 242.4 In-house 1-298 (315) alignment 
Range on Protein: 1224-1521
Range on HMM: 1-298/315.0
QSISVSMFPDYVKRLHanTDHLFSEEYELITiKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLA
| | |. || .|.. .     |||||.  .    .  .. ....| | .||||.||  .|..||.|  |  .  |||||| || .. .  .||| |||| 
qpipvaqfpafvnknr..htalfseefhdlp.dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlk

ETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQ--TGSTTFGELTVTIIDQQVLAYYTIRTFkINNKDDESFEVKQFHYTAWPDFGVPDHPNPII
 .  |||||....|.. |||.|.  |  . || ||||.  . |. ||.. |.... .  .  ..| . .  | .||  | ||..| ||| ||. .   ..
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssll

SFIRRVNN--STHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPKEAKIL
 .|. |     ... .|.|||||||||.| .|.|....  .. .  |||||||  .| || |.|||| .| |..|.. | ..  |.  .| .|    . |
klikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdl

LT
 |
ht
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1545-1801 2.8e-72 238.7 In-house 40-291 (319) alignment 
Range on Protein: 1545-1801
Range on HMM: 40-291/319.0
FEKLNSIDVAIPSQYiSASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCgl
| ..  . |    |   | |. |. |||. .||...  .|.|  | |. .|||||||.|.|| | ...| .|||| ||..||||||||...|.||.|   
frracklgvnladqt.fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..

vedgKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHH-LFGGGPVVVHDS
    ||.  ||||..   ... . ..  | ..|  ||.|.| ...  . ...|.|.|||.  | .   |  .  || ..  |.. ..   .  ..||| |
....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcs

SSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVE-Y
. |||.|.. .......|.| | ..|.. ... ||.. . .| .. |.||.| ...| .
aGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_PTPRB_pd Subfamily PTPRB 1543-1804 8.8e-72 236.6 In-house 29-287 (293) alignment 
Range on Protein: 1543-1804
Range on HMM: 29-287/293.0
KQFEKLNSIDVAipSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLC
...|.|....     .  .|.|.|||||||| .||||.  ||.|  | . ||||||||.|..||   ..|| ||||| .||||||||.||...|.|||| 
eeyeelkavgkd..qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmlt

GLVEDGKDQSVQYWPKD-QLTQYGDMFIETISETDTGFYVIREITITHtkqGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAH-HLFGGGPVVV
 ||| || .  .|||.| . ..|||. .. ..|...  .||||..|..   ..| |...|.|.| |..   | .| .|.|..  |..|. .    .|.||
qlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

HDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLES
| |. |||.|||  .. ...... | ..||| ....||..   .| . .|. | .|.....|..
hCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1564-1810 2e-71 235.1 In-house 6-250 (250) alignment 
Range on Protein: 1564-1810
Range on HMM: 6-250/250.0
LPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDqSVQYWPKDQLTQ
 | |. |||| ||....| || |    |   |||||||...||   . ||.|||||..|. |||||..|. ...||||  |.| .|    |||| .. ..
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

YGDMFIETISETDTGFYVIREITITHTKQGNEvRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGGPVVVHDSSSVGRSGTFCIINIVIERLK
|||. ..  |.   . |..|.. ....|. .| | ..|.|.. | .   | .. | ....  ||. .   | .||.|. |. |||||.|..|. |.||||
yGdvtvsllskeefadytkrklklskakkade.rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

VEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFDKYAN
 | ..|.|  |..||.. |. |   .|. |.|. | ..|.|.. ||.
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
Y_phosphatase Protein-tyrosine phosphatase 1567-1800 2.1e-71 235.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 1567-1800
Range on HMM: 1-235/235.0
NRAKNRYPDILPYESYRVRLlmlPGVSG-SDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWP--KDQLTQ
|. ||||.|||||.. ||.|    | .| ||||||.||.|| . ..||.|||||..|..|||||.|...|..||||. |.| |. .  ||||  ... ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDMFIETI-SET-DTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHhLFGGGPVVVHDSSSVGRSGTFCIINIVIER
|||...|.  .|. |.  |..|.......|. .| | .||.|||.| ....| .. .|.|.|  |.| .     |||||| |  |||.|||. ..|..|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

LKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVE
|. |. .|.. ..  ||.. ||.| ...|..|.|..|.|
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1567-1800 2.1e-71 235.5 In-house 1-235 (235) alignment 
Range on Protein: 1567-1800
Range on HMM: 1-235/235.0
NRAKNRYPDILPYESYRVRLlmlPGVSG-SDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWP--KDQLTQ
|. ||||.|||||.. ||.|    | .| ||||||.||.|| . ..||.|||||..|..|||||.|...|..||||. |.| |. .  ||||  ... ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDMFIETI-SET-DTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHhLFGGGPVVVHDSSSVGRSGTFCIINIVIER
|||...|.  .|. |.  |..|.......|. .| | .||.|||.| ....| .. .|.|.|  |.| .     |||||| |  |||.|||. ..|..|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

LKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVE
|. |. .|.. ..  ||.. ||.| ...|..|.|..|.|
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1561-1801 2.3e-71 235.6 In-house 19-255 (284) alignment 
Range on Protein: 1561-1801
Range on HMM: 19-255/284.0
SASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCglvedgKDQSVQYWPKDQ
 | |. |. |||. .||...  .|.|  | |. .|||||||.. || | ...| ||||| ||..||||||||...|.||.|       ||.  ||||.. 
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki

LTQYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHH-LFGGGPVVVHDSSSVGRSGTFCIINIVI
  ... . ..  | ...  ||.|.| ...  . ...|.|.|||.  | .   |  .  || ..  |.. ..   .  ..||| |. |||.|.. ......
vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvll

ERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVE-Y
.|.| | ..|.. ... ||.. . .| .. |.||.| ...| .
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1543-1801 3e-71 234.8 In-house 25-278 (288) alignment 
Range on Protein: 1543-1801
Range on HMM: 25-278/288.0
KQFEKLNSIDVAipSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLC
.....| ...    ..   ..|.||  ||||..||||.  ||.|  |. ..|.|||||||.||. . ...| ||||| .||.|||....|...| |||| 
eeynsLaalekt..ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmlt

GLVEDGKDQSVQYWPKDQL-TQYGDMFIETISETDTGFYVIREITIThtKQGNEvRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFgGGPVVVH
.|||.|| .  .|||...  ..||.. .. ... ... .| |.. .   |...| ..|.|..|. |.... |  .  |....  |. |..    ||..||
elveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkte.leitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivh

DSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEY
 |  |||.|||  .. .|.... | .||.. |.. ||.. . .| .  |. |.|..... 
CsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1226-1500 7.2e-71 233.4 In-house 2-283 (290) alignment 
Range on Protein: 1226-1500
Range on HMM: 2-283/290.0
ISVSMFPDYVKRLHANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEG--SDYINANYIDGYGSRDTYIACQGPLA
| |. | ..|   ||. .. | .... .   . .   .    . | ..||. ||   |. |..| .|.| .    .|||| ||.||  .  ||| |||. 
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINNKDD--ESFEVKQFHYTAWPDFGVPDHPNPII
.|  |||..||..|...|||||| .|.|. ||.||||.......|| .........| .|..|.....||.   .. .|.|.. |.|.. |   .|. |.
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

SFIRRVNN---STHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
. |.....    .  ...|||||..||||..|.|..  .  ..||| .|||. .  .| ..  .|||. || .... ... .
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPRK_pd Subfamily PTPRK 1564-1800 7.2e-71 233.6 In-house 40-275 (314) alignment 
Range on Protein: 1564-1800
Range on HMM: 40-275/314.0
LPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQLTq
   ||.|||. |||.|.  ||.|  . | . ||||||...|.| | ..||.||||| .|| ||||...... ..||||  ||| |. . ..|||.|  . 
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.

YGDMFIETISETDTGFYVIREITITH-TKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLfGGGPVVVHDSSSVGRSGTFCIINIVIERL
|||. .| .. .    .|.|  .... ... .|.| ..||... |.. ..|    .|....  |.| ..  . |..||| |.  ||.|||..|.||.. .
ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmi

KVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVE
. ||..|.|.....|| ... .|   .|.||.|. |.|
eregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1226-1505 1.1e-70 232.9 In-house 2-283 (287) alignment 
Range on Protein: 1226-1505
Range on HMM: 2-283/287.0
ISVSMFPDYVKRLHANTDHLFSEEYELITI---KSPSLPHEASQQtcNIEKNRYGNINSFDETRVVLTkipgIEGSDYINANYIDGYGSRDTYIACQGPL
|.|..| ..|.. ||. .  |.. . ..     .  .. |. ..|  | .|||. .|   |. ||.|      |  ||||| .|||| ..  .|....|.
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasq..nkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPm

AETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINN--KDDESFEVKQFHYTAWPDFG-VPDHPNP
..|  .||..|.... . ||||..  |. . .|.||||.. |...|| ........| | |..|.....|  |...  .|||...|.|.. | |...   
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

IISFIRRVNNSTH--TGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNS
.. . ... .  .   ...|||||..||||..|.|..  .   .||| .|||. .  .| ..  .||| .||.|. | ..| .. .. 
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_PTPN1_pd Subfamily PTPN1 1242-1514 2.2e-70 231.7 In-house 4-285 (290) alignment 
Range on Protein: 1242-1514
Range on HMM: 4-285/290.0
TDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKipgiEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCI
...|..| |. |. ..  .|......  | ..||| ... .| .|..| .    .  |||||. ..    .  ||  ||||..|   ||.|.||||. ..
kkrlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikler....adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskav

VMLTNCVEKGRPKCHQYWPQTGS---TTFG--ELTVTIIDQQVLAYYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNS----T
||| ..|||.. ||.|||||  .    ..   .|.|..| ...  |||.|.....| | .|. |. .||||.|||||||. |.  ..|. .| .|    .
vmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslss

HTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGK---VDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPK
. || |.|||||.||||||. . .... .| ...   ||. . .|..|. |  ..||  |  | . ...| .|| ... .||.  |
dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqkrwk
subfamily_PTPN13_pd Subfamily PTPN13 1247-1501 2.4e-69 228.6 In-house 14-270 (273) alignment 
Range on Protein: 1247-1501
Range on HMM: 14-270/273.0
SEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGiegsdYINANYIDGYGSRDT--YIACQGPLAETSPDFWRMIWEQKTSCIVML
.||.. .    | .  | ...  | .|||| |.  .||||| | .  |     ||||..|      |.  |||||||| ||  |||.|.||||.. |.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TNCVEKGRPKCHQYWPQTGSTT---FGELTVTIIDQQVLAYYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSTH-TGPLVVH
|. .|||. |||.|||.. . .    . |.|. ...| |  ...|...... .  || || ......||| ||| ...... |...|..  . .||.|||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvh

CSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
||||.|||||.|.|. .. ..| . ..|| . | ..|..|. .|||. ||.||. ...|..|
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1265-1500 3.4e-68 224.7 In-house 23-268 (274) alignment 
Range on Protein: 1265-1500
Range on HMM: 23-268/274.0
SQQTCNIEKNRYGNINSFDETRVVLT-KIPGIEGSDYINANYIDGYGSR-DTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQT
 . . . .|||| .|   ...||.|. . .  | |.||||||| ||. .  .|.| ||||..|  ||||||...... |||||.  |. . ||..|.|..
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

GST----TFGELTVTIIDQQVLAYYTIRTFKINNKDDeSFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNS-----THTGPLVVHCSAGVGRSGTFIAI
 ..    ..|.. ... .      |..|.. ...  . . .|| . ||.|||  .||..|....... |..|     ....| |||||||.|| | ||||
edyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

QSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
.  .  .. |..|||.. | ..| .|  ||||. || ..|  |..  
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_PTPN12_pd Subfamily PTPN12 1561-1803 3.5e-67 221.3 In-house 34-278 (290) alignment 
Range on Protein: 1561-1803
Range on HMM: 34-278/290.0
SASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKD-
... ..|..|||| |||||.  || |    .. |||||||... |     ..| .||||..|.|||||||||..|. .||.| .|| || .  .|||.  
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

-QLTQYGDMFIETISETDTG-FYVIREITITHTkqgNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlFGGGPVVVHDSSSVGRSGTFCIINI
 . ...|.. .....|  .   ..|| .....    .| |...|||||.| .  .| ..  |...| ||.. ..     |.||| |. ||| || . |..
eeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidy

VIERLKVEGM---IDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLE
| | || | .   .|.|  .  ||.. . .|   .|... |....|...
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
0037934 (Phosphotyrosine protein) phosphatases II 1561-1802 3.7e-67 221.7 In-house 4-242 (243) alignment 
Range on Protein: 1561-1802
Range on HMM: 4-242/243.0
SASLPVNRAKNRYPDILPYESYRVRLlmlpgvSGSDYINASYVDGYlrcNQFIMTQGPLSNTVDD----FWRMIWEHRVSAIVMLCGLVEDGKDQSVQYW
 |.||.|. ||||.|||||.  ||.|      .|||||||......   ...| |||||..||.|    ||||.||.....||||. ||| |. . .|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PkDQLtQYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHL-------FGGGPVVVHDSSSVGRS
| ..  .|||......||. .. |..|........ ....|.. ..||. | ....|...  |.|..  |..  .         .||||.|| |  |||.
p.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFCIINIVIERLkveGmIDIFFTIHALRRKHPG-IVANYDQFKFCYQTIVEYL
||.... .....|   | .|.. ... ||.. || .| ...|..|.|. . |.|
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1222-1509 3.4e-66 218.4 In-house 6-293 (297) alignment 
Range on Protein: 1222-1509
Range on HMM: 6-293/297.0
QRQSISVSMFPDYVKRlhANTDHLFSEEYeLITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYgsRDTYIACQGP
.|. | .| |. .|..      ..||||. | . ..   |   ...  |.||.|| ||  .|  || |  .     |||.|| .. |.  .  .|. | |
errpiplsdfatlvqk..nrhtdvfseef.lclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgn..khrlittqmP

LAETSPDFWRMIWEQKTSCIVMLTNCVEKGRpKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINNKD-DESFEVKQFHYTAWPDFGVPD--HPN
  .|  |||.|......| ||||..  |. . || .||...|.||||...|..   .    .  |...... .      |||.... |||  |.   . .
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsas

PIISFIRRVNNS---THTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTV
 .. .|  |...   .  |||.|||.||||| | ...|.|..  .. | .||.|..|  .|..| |.|||. || ||.  ..| .   . .  .
sllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
subfamily_PTPN6_pd Subfamily PTPN6 1541-1807 2.2e-65 215.7 In-house 28-302 (306) alignment 
Range on Protein: 1541-1807
Range on HMM: 28-302/306.0
LPKQFEKLNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLmLPGVSGSDYINASYVDGYLR--CNQFIMTQGPLSNTVDDFWRMIWEHRVSAI
. ..||.|.  ..    .   .. | |. ||||  |||..  || |   |.|.|||||||.|... ..  ....| ||| |..|| |||||.|.     |
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvi

VMLCGLVEDGKDQSVQYWPKDQ-LTQYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFG---
||.   || ||.. ..|||. .  ..||.. ....||...  |..||......|...| |.. |.|...| .. .|  .||..|..  |.. .. .    
vmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeae

GGPVVVHDSSSVGRSGTFCIINIVIERLKVEGM---IDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFDK
 ||.||| |. .|| ||| .|.|... .. .|.   |||  ... .|. . |.|   .|.|| |..| .|.|.  |
agpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1544-1811 3.9e-65 214.7 In-house 25-287 (287) alignment 
Range on Protein: 1544-1811
Range on HMM: 25-287/287.0
QFEKLNSIDVAiPSQYISASLPVNRAKNRYPDILPYESYRVRLLmlpgVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCG
||  |....   . .   .  . |. |||. .||... ||| |         |||||...|||   ..||....|..||. .||..|....|.|||||| 
qftvleqvtqr.edevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcq

LVEDGKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGGPVVVHDS
. |. ...  ||||... . .|.  || ..|. .  |..|.. ...... .. ...||...|.| ..   ..  . . .|    |...  | ...||| |
ekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCs

SSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFDKYANF
 .||||..|| ... |.. | || ||.|  ..  | ..|| |   .|.|| .. ..|||.||. |..|
dtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1270-1498 4.9e-65 214.1 In-house 3-237 (237) alignment 
Range on Protein: 1270-1498
Range on HMM: 3-237/237.0
NIEKNRYGNINSFDETRVVLTKiPGiEGSDYINANYIDGY-GSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGS-TTF
|  |||||||...| .||||   .|  |||||||.|..|. |.  .|||.||||  .  |||.|.|..| | |||||  .|. . |||.|||.|   ...
nkiknrygnivaydhsrvvlkg.ag.sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GELTVTIIDQQVLAYYTIRTFKINNKDD--ESFEVKQFHYTAWPDFGVPDHPNPIISFIRR-VNNSTH---TGPLVVHCSAGVGRSGTFIAIQSMMLMME
| |||..  .. .. ||.|.. . ..    |   ..|...|.||| |||..   .. | .. .|.| |   .|| ..||||||||.| |. |..|.   .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

TEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVE
 .  ||..|.|  .   | |..||. ||.|.|....|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1543-1808 7.8e-65 213.6 In-house 24-289 (290) alignment 
Range on Protein: 1543-1808
Range on HMM: 24-289/290.0
KQFEKLNSidVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSG--SDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVM
.||..|.|   . . .   .  . |. .||. .|..|. .|. |  ..|      .||||.|..||   .|.|.||||.|||. |||..||...|..|||
nqfkmlds..gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivm

LCGLVEDGKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGGPVVV
|.  .|.||..  ||||. . ..|| . |. ..|. .  |..|.. ......... ....|.. | | ..   . . . . .|  ..| ..  | ...||
ltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivv

HDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFDKY
| | .||||..|| ... |.. | || ||.|  .. .| ..|| |   .|... .| ...||.||..|
HCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_PTPN9_pd Subfamily PTPN9 1543-1803 3e-64 211.9 In-house 20-291 (297) alignment 
Range on Protein: 1543-1803
Range on HMM: 20-291/297.0
KQFEKLNSIDVAipSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLC
|..... .  |.   ..  . |..|  |||| |.| |.. || |  ... . ||||||..|||| . . || ||||| .||.|||||.||..|  |||  
keyaeirnepve..GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmtt

GLVEDGKDQSVQYWP--KDQLTQYGDMFIETISETDTGFYVIREITITHTKQgNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHH---------
 .|| |. .  ||||  ... ...||. .....   .  |..| ..|...|. .| |..  | .. | .  .| .. .|.|..  |...           
rvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgde

---LFGGGPVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLE
      | |.||| |. .||.|||. ..| ..||. .|..|.. |.. || .    .   .|..|||....||  
wkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1268-1501 3.6e-64 211.3 In-house 18-265 (270) alignment 
Range on Protein: 1268-1501
Range on HMM: 18-265/270.0
TCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGS-RDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGS--
. . . ||| .|    .|||.| ..   . . ||||||. |. . . .||| .|||. |  .|||||||.|...|||.|. .|||| || .|||.     
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

--TTFGELTVTIIDQQVLAYYTIRTFKINnKDDESFEVKQFHYTAWPDFGVPDHPN------PIISFIRRV---NNSTHT-GPLVVHCSAGVGRSGTFIA
  ...|...|. . ..    | ..  ... .. |. ..  |.|..||| ||| ...       ... .| |   .....  .||.|||||||||.||.||
vkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
.  .. ..|...|||| . . ..|..|  .||.  || |.. ..|| ..
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1263-1497 2e-63 208.7 In-house 1-238 (239) alignment 
Range on Protein: 1263-1497
Range on HMM: 1-238/239.0
EASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGY-GSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQ
||...  |  |||| || ..| .|||| |.     ||||||.|.  | ||  .||| || .. .| |||||.|...   |||||  .|  . |||||||.
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

TGStTFGELTVTIIDQQVLAYYTIRTFKINNK-DDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSTHTG--PLVVHCSAGVGRSGTFIAIQSMML
. |  . .| ||.   .|.| | |||| ...  . |   | |.|.| ||| |||..   .. . |.. . .  |  | |.||||||||.|.|. |..|. 
sts.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

MMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLV
  . .  ||.||.|  .|  | .||||  ||.|.| ...
qakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1265-1498 4.5e-63 207.6 In-house 2-238 (239) alignment 
Range on Protein: 1265-1498
Range on HMM: 2-238/239.0
SQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGY-GSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTG
...  |  |||| || ..| .|||| |.     ||||||.|.  | ||  .||| || .. .| |||||.|...   |||||  .|  . |||||||.. 
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

StTFGELTVTIIDQQVLAYYTIRTFKINNK-DDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSTHTG--PLVVHCSAGVGRSGTFIAIQSMMLMM
|  . .| ||.   .|.| | |||| ...  . |   | |.|.| ||| |||..   .. . |.. . .  |  | |.||||||||.|.|. |..|.   
s.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

ETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVE
. .  ||.||.|  .|  | .||||  ||.|.| ...|
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_CG7180_pd Subfamily CG7180 1567-1802 9.7e-63 206.5 In-house 42-290 (296) alignment 
Range on Protein: 1567-1802
Range on HMM: 42-290/296.0
NRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKdQSVQYWPKDQLTQYGD
|| |||.....||.  || |  | | . ||||||.|||..|. ...|.|..|  .|||.|||..... .||.|.|.   .  | .  .|||... .|||.
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

MFIETISETDTGFYVIREITITHT---------KQGNEVRNIKQFHYTDWSE-NKTPPTTGALMDMIVLVQKAHHLF----GGGPVVVHDSSSVGRSGTF
.|.|...|      .||.. .|..         .   |.| .|.|..| |   .| |  | ||....  |..  .        |||||. |  ..||| .
ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvy

CIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
. |.. .| .. |. .|.|  .  |||. |..| | ...|..|... |..
laidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1259-1501 5.8e-62 204.1 In-house 25-278 (287) alignment 
Range on Protein: 1259-1501
Range on HMM: 25-278/287.0
SL--PHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGiEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCH
|      |.... ...||||...  .|.|||.|.. .   |||||||||. .|   ...||.|||.| |  ||||...|.... ....|  ||..| ||.
sstatfkaaeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPQTGS-TTFGELTVTIIDQQVLA-YYTIRTFKINNKDDES-FEVKQFHYTAWPDFGVPDHPNPIISFIRRV-------NNSTHTGPLVVHCSAGVGR
.|||.       |  .|...|....   |..|.... . . .    |||... .||| ...     .| |.  |        ... .||||||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

SGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
||...|.  .. ..|  |.||| . |. .| .|. .||.  |. .. ..||   |
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1566-1802 1.7e-61 202.9 In-house 48-279 (315) alignment 
Range on Protein: 1566-1802
Range on HMM: 48-279/315.0
VNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQLTqYG
 |. |||| .|..|.  ||.| .|   ..|||.||...||| . ...| .|||. ..|.||||...|. .. |||| .|||. | .. .||| .... ||
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkvi.yG

DMFIETISETDTGFYVIREItitHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVqKAHHLFGGGPVVVHDSSSVGRSGTFCIINIVIERLKVE
 . .  .||     | .| .    .  |...|.. |.||| | . . |  | .||..|  | | ||    |..||| |. |||.|||. .. |......|
kitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtv.kqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeae

GMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
 .||..  |. .|..  ..|.  .|..| |....| .
naidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1223-1525 6.5e-61 200.9 In-house 1-261 (392) alignment 
Range on Protein: 1223-1525
Range on HMM: 1-261/392.0
RQSISVSMFPDYVKRLHanTDHLFSEEYELITiKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPL
|| | |. || .|.. .     ||.||.  .    .  |. ..|.  |..||||.||  .|..||.|  |  |  |||.|| ||... .  .|||.||| 
rqpipvaqfpafveknr..hsalffeefhdlp.gpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpn

AETSPDFWRMIWEQKTSCIVMLTNCVEKGrpkchqywpqtgsttfgeltvtiidqqvlayytirtfkinnKDDESFEVKQFHYTAWPDFGVPDHPNPIIS
| .  |||||....... |.|.|.  |                                           | |.   | |||.| ||| .|| | . .. 
aaslddfwrmvfqenvttiamvtklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllk

FIRRVN--NSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSEQTVQNFPKEAKILL
||. |.     .| ||..||||||||.|  |.|.|..   ..   ||||||| ..|.|| |||||. || |.. ...| .   |.   |  |    ..| 
fikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls

TTQED
|. . 
tssdG
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1557-1803 5.2e-59 194.6 In-house 34-278 (315) alignment 
Range on Protein: 1557-1803
Range on HMM: 34-278/315.0
SQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYW
..  .|  ..|  |||| .|||..| ||.| ..     ||||||||. ..   . .| .||||  .|||||||.....|..|||.  . |. | .  |||
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PK--DQLTQYGDMFIETISETDTGFYVIREItitHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAhHLFGGGPVVVHDSSSVGRSGTFCI
|.   .....| . .|..|   ..  |.|..    |....| |.. ||..|.| .. ..  |..|. .|  |.   .     ...|| |. |||.| .. 
PdrkadsvefGsikvellsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvis

INIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLE
|. |....| . ..|.| ... ||.| | .|   ... | |... |.| 
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_CG7180_pd Subfamily CG7180 1266-1500 5.4e-59 194.3 In-house 38-290 (296) alignment 
Range on Protein: 1266-1500
Range on HMM: 38-290/296.0
QQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRpKCHQYWPQTGST
 .. |.||||. ..  .| .||||.|. | | |||||| |.|..     ||  ..|  ||  .|||.......|..|.||.  .  . ....|||... .
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkske

TFGELTVTIIDQQVLAYYTIRTFKINNK--------DDES---FEVKQFHYTAWPD-FGVPDHPNPIISFIRRVNN-------STHTGPLVVHCSAGVGR
 .||. | |. .. .|  .|||||.. |         ...     ||.|..| |.    ||   | .| ..|||.          ..||.||..| |..|
qygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasR

SGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
|| ..||.  . ..| |..||||..|  .|..|. .|..  .|... | | | .
sGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1543-1804 7.7e-59 194.1 In-house 19-278 (281) alignment 
Range on Protein: 1543-1804
Range on HMM: 19-278/281.0
KQFEKLNSIDVAIPSQyiSASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLC
...|||..|.|  ...  ..  . |. |||| .|  |.  ||..      . .|||||..|.||   ...| ||||. .....||.|.||..||||||. 
eeyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvt

GLVEDGKDQSVQYWPKDQ-LTQYGDMFIETISETDTGFYVIREITIthTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGGPVVVH
  .| || .  .||| |.  ..|||. .....|...  |. |....  .....| |...|..|| | ..  | || .|..    |.|...     |.|.|
reieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvih

DSSSVGRSGTFCIINIVIERLKVE-GMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLES
 |. |||.||.  .. ...... |  ..|.  ... ||..   .|    |..| |......|. 
CsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1563-1803 1.7e-58 193.0 In-house 39-277 (515) alignment 
Range on Protein: 1563-1803
Range on HMM: 39-277/515.0
SLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPK--DQ
   .|  |||| .||||.| ||.| ..     |||.||||. ..   . .| .|||.  .||||||......|..|.|.  | |. | .  .|||.   .
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

LTQYGDMFIETISETDTGFYVIREITIThtkQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGgGPVVVHDSSSVGRSGTFCIINIVIE
  ..| . .|..|    .  ..|..|..   .|...| . |||.|.| .. .|. | .|. .|  |.  |  .   |...| |. ||| | .. |. |. 
svkfGsikvelvsleactggikrkltvl...kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvva

RLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLE
. |   |.|.| ... .|.| | .|   .|. | |... |.| 
hakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPN23_pd Subfamily PTPN23 1268-1500 2.1e-58 192.4 In-house 41-280 (288) alignment 
Range on Protein: 1268-1500
Range on HMM: 41-280/288.0
TCNIEKNRYGNINSFDETRVVLTkipgIEGSDYINANYIDGYGSR-DTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTG--S
 .. ||||. .|  .|..||.|      .  ||||| .. .  .   ..|| |.||..|. |||.|..|||.| ||||..  |.|.||...|||.    .
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

TTFGELTVTIIDQQVLAYYTIRTFKINNKD-DESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNN-------STHTgPLVVHCSAGVGRSGTFIAIQSM
..||.|.||. ... . ..  |..|.. .| |.  .|.  ..|.||..|||. |. .. |.  |..        ..| ||||||||||||.|.|  . . 
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt.PlvvhCsaGvgRtgvfalvyaa

MLM-METEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
.    . .| .|. . |  .|..| .|||...|. |. .  .| .
vrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1240-1506 6e-58 191.0 In-house 5-272 (283) alignment 
Range on Protein: 1240-1506
Range on HMM: 5-272/283.0
ANTDHLFSEEYELITIksPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGiegsDYINANYID---GYGSRDTYIACQGPLAETSPDFWRMIWEQ
.|. .|| | .. ...  |.|. . .    | .|||. .| . |  || |   .     ||||| .|     |     ||..|.|| .|  |||.|....
vnnnklfrevlkrlsv..pdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

KTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLAYYTIRTFKINNK--DDESFEVKQFHYTAWPDFGVPDHPNPIISF--IRRVNNSTH
| ..|||||.  |  | || ||||. ||  .||.|||. ..     ..|. . ....    ... .  . .  | ..|     | .. |  ..   .  .
kitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtesk

TGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNSE
 ||.|||||.|.||...|||. . .  . ||  ||||. |  || .|  .|||  ||..||.  .|   .|...
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtq
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1562-1806 1.5e-57 190.0 In-house 46-288 (297) alignment 
Range on Protein: 1562-1806
Range on HMM: 46-288/297.0
ASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRcnQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKdQSVQYWPKDQL
|   ||  |.|| .||||.| ||.| ..     |||.|||.| |.    ..| || |  .||.|||.|.....||.||||  . |  | .  .||...  
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

TQYGDMFIETISETDTGFYVIREITITHTKQgNEVRNIKQFHYTDWSENKTPP--TTGALMDMIVLVQKAHHLFGGGPVVVHDSSSVGRSGTFCIINIVI
|..||. ... | ..   .. ||...|. |     | .||.....| ... .   .. .|...|  |.| .     ||..|| .. ||| | .. |. |.
ttfGdvsvvllsvsereGfikrelevtkgka.karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

ERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFD
 . | |  .||| ... ||.. | .|   .|.|| |....|.| | |
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
0051429 (Phosphotyrosine protein) phosphatases II 1295-1501 3.3e-57 189.5 In-house 1-226 (272) alignment 
Range on Protein: 1295-1501
Range on HMM: 1-226/272.0
IEGSDYINANYIDGYGS---RDTYIACQGPLAETSPDFWRMiWEQKTSCIVMLTNCVEKGRPKCHQYWP------------QTGSTTFGELTVTIIDQQV
.. |.||||....|||.   ........|||  |  ||||. .|.. ..||.|....|.|| ||..|||             . . ..| |.||..  ..
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LAYYTIRTFKINNK--DDESFEVKQFHYTAWPDFGVPDHPnpIISFIRRVNNsthTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVD--------VF
| .|..|.. . ..   .|..|| ..|||.|||.|||...  ...... ...    ||..||||||..|.||..|.  ..| .. |  ||        ..
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

NFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
..|  .| .| ..||||.||.|... |.||..
eaveelraqrpgavqteeqylflyeallellr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1547-1804 9.3e-57 187.2 In-house 6-270 (274) alignment 
Range on Protein: 1547-1804
Range on HMM: 6-270/274.0
KLNSIDVAIPSQY--ISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSG-SDYINASYVDGYLR-CNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLC
.|..  . .|. .     ... .  |||| .||| |  || |    . .  |.|||| |. || .  . .. |||||.|||.||||||....|. |||| 
dlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmlt

GLVEDGKDQSVQYWPKDQLT----QYGDMFIETISETDTGFYVIREITITHTKQgneVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGG--G
 | |  ... ..|.|... .    .|||. |.. . ...  | .|.... ....    |..| . |||| ..|.|  . .|.|..  |.....      .
klkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenakla

PVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLES
||||| |. .|| | |  |.| . .|. |...|.. ..  || .  |.| . .|... ......||. 
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPRN_pd Subfamily PTPRN 1234-1498 1.1e-56 186.7 In-house 20-290 (297) alignment 
Range on Protein: 1234-1498
Range on HMM: 20-290/297.0
YVKRLHANTDHLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSR-DTYIACQGPLAETSPDFWRM
|..    | |.|  |   | . ..    .|....  |..|||. .. ..|..|| |..    | ||||||  |     |  .|||.|||||.|  |||.|
yledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqm

IWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFGELTVTIIDQQVLA-YYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNS
.||| .  ||.||.  |.|  .|..|||..|| ...   | .. . . .  | .|.| . | . .|.  | |||. .||. |||  ..... | |.|| |
vweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnks

T--HTGPLVVHCSAGVGRSGTFIAIQSMML-MMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVE
    . |.|||||.|.||.|..|.|. ..  ..    ..|.   .  .| .|. .|.|..|. |.  ...|
yrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1241-1504 1.3e-55 183.3 In-house 13-297 (301) alignment 
Range on Protein: 1241-1504
Range on HMM: 13-297/301.0
NTDHlFSEEYELITIKSPsLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPG--IEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKT
.... |.|.|. .. ...  . . . .  | . ||. ||. .|. |..|.. |   .   .||||.||||| ..  .|| |||. .|  ||||.||..|.
hsnk.feeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

SCIVMLTNCVEKGRPKCHQYWPQ--TGSTTFGELTVTIIDQQVLAYYTIRTFKIN----------------NKDDESFEVKQFHYTAWPDFGVPDHPNPI
. |||.||  |. . ||.||||.  . |..||..|||....||.  ..|| ....                ..| .| .| |.. | ||. ||   |. .
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

ISFIRRV---NNSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGN
.  |  |   ...   ||.|||||..|.|||......  .     || ||||. .  .|...  .|.|  ||....| . . ... .
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
subfamily_PTPN14_pd Subfamily PTPN14 1245-1501 3e-55 182.3 In-house 25-297 (300) alignment 
Range on Protein: 1245-1501
Range on HMM: 25-297/300.0
LFsEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIeGSDYINANYIDGY--GSRDTYIACQGPLAETSPDFWRMIWEQKTSCIV
.|  ||| |. |.     ....   | ||||. ..  ....|| |.       ..||||  |     |.. .||..||||  |  |||.|.|||... ||
vf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqliv

MLTNCVEKGRPKCHQYWPQTG----STTFGELTVTIIDQQVLAYYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVN------NST
|||.  |.|. |...|.|...    . .||.  ||   ..    .. ...|..     |  .|  . || ||| |||. ... .|....|.      ||.
mlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnse

H-----TGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
        |..|||||||||.|  |  . ..  .|.. ..|. . .  .|..| ..||| ||| ||.. |.. .|
veskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1564-1810 1e-54 180.3 In-house 37-301 (301) alignment 
Range on Protein: 1564-1810
Range on HMM: 37-301/301.0
LPVNRAKNRYPDILPYESYRVRLLMLPG--VSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQL
   |.| ||. .| .|.  |. |   |   ..  .||||||.||| . ..||..|||. .|. ||||.||......|||...| |. |... ||||. . 
seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnsea

TQ--YGDMFIETISETDTGFYVIREITITHTKQGN--------------EVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGGPVVVHDSSS
..  .| . .. ..|.    .|||..... ..  |              . ... |.. ||| ..   .     .  |  | .. .  |||||||| | .
eseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdt

VGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFDKYAN
|.|||..| ..| .|  | || .|.|  ..|.||..|| |   .|. . |. | .||.  . |||
VsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1559-1804 1.8e-54 180.0 In-house 40-290 (325) alignment 
Range on Protein: 1559-1804
Range on HMM: 40-290/325.0
YISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRvSAIVMLCGLVEDGKDQSVQYWPK
.  | .| |.||||........  || |  .   . ||||||||.  . . . |. .| ||..|..|.||.. . | ...|..   .. |||.  .||||
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpk

D--QLTQYGDMFIETISETDTGFYVIREITITHTKQGnEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLF-----GGGPVVVHDSSSVGRSGT
.  .  ..| . .. ..  .   || | . .  .|.| | | .|||..  | .  ..    .|. .. ||.. .        . .|..|| |. |||.|.
emgksktfGglevklrtieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

FCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLES
|  .  .....  |  .|||  .. ||.. | .|   ||. ..|...||.. |
fislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1567-1804 2.9e-54 178.9 In-house 20-266 (270) alignment 
Range on Protein: 1567-1804
Range on HMM: 20-266/270.0
NRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLR-CNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQL--TQ
... ||| ||||    ||||  |   | . |||| || |.    ...| ..||| .|. .|||||||..|.||||. ||.|.|...  .|||...   ..
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

YGDMFIETIS--ETDTGFYVIREITIThtKQGNEVRNIkQFHYTDWSENKTPPTTG------ALMDMIVLVQKAHHLF-GGGPVVVHDSSSVGRSGTFCI
. |..|....  |. . .|........  ..|.| | .  |.|..| ..  |....       |. |.  |.. .. .  ..|..||.|  |||.||. .
ledgkikvlalseekeegyiltrlrle..ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

INIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLES
..|... |. .. .|.   |..||.. . .|   .|..| |...||| | 
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPN3_pd Subfamily PTPN3 1559-1801 1.1e-53 177.0 In-house 33-274 (280) alignment 
Range on Protein: 1559-1801
Range on HMM: 33-274/280.0
YISASLPVNRAKNRYPDILPYESYRVRLLMlpgvSGSDYINASYVD----GYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQ
   | .| | .|||| |||||.. ||.|      | .|||||.||.    .    |..| |||||..|. |||.|.||...| ||||  |||.|. .  |
isaarkpenlsknryrdilpydatrvklke....setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPKD-QLTQYGDMFIETISETDTGFYVIREITITHTKQgNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLfGGGPVVVHDSSSVGRSGTFC
|||.  . ..||.. ..  .|  |  ||.||........ .| |.| |. |..|.... |  .  .....  |.|...     ||||| |. .||.| . 
yWPetedeleygefsvkcekedetksyvlrelvlkdket.keerkilqlqylaWpdhgvPddsadflefvervrklrsg.keePvvvhCsaGigrtGvli

IINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEY
.... .  .  .  . .   .. .| .   .| . .|.||  ..|.. 
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
0041856 (Phosphotyrosine protein) phosphatases II 1270-1504 2.7e-53 175.6 In-house 1-175 (182) alignment 
Range on Protein: 1270-1504
Range on HMM: 1-175/182.0
NIEKNRYGNINSFDETRvvltkipgieGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTncvekgrpkCHQYWPqtgsttfge
|..|||| .|  .| .|          ..||||||...|.   ...||.|||| .| .||.||..|.. ..||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

ltvtiidqqvlayytirtfkinnkDDESFEVKQFHYTAWPDFGVPDhPNPIISFIRRVNNstHTGPLVVHCSAGVGRSGTFIAIQSMMLMmetegKVDVF
                        ...  .. |..|. |||.|||| .. ...||..|..  . || .|||||||||.||..|.  |. .     .|...
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

NFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGN
. |  .| .|. ||.|. || |... | ||.....
eavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_PTPN23_pd Subfamily PTPN23 1541-1804 3e-53 175.5 In-house 17-282 (288) alignment 
Range on Protein: 1541-1804
Range on HMM: 17-282/288.0
LPKQFEKLNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLmlpgVSGSDYINASYVDGYL-RCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIV
| |.|..|.. . .   .   |   ..  |||. |||||.. || |      |  ||||||.| .    | .||.||.|| .|. |||.|..| ..| ||
ldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviV

MLCGLVEDGKDQSVQYWPK--DQLTQYGDMFIETISETDTGFYVIREITITHTKQgNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLF---G
||    | || .  .|||.  .. ...||. .   |...|. .| |...... .. ..|....  ..| |.|   | . . |....  |..|..      
mllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda.davksvshlqltsWpelGvPasPetllqfldevesayeavqrks

GGPVVVHDSSSVGRSGTFCIINIVIERLKV-EGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLES
  |.||| |. |||.|.|...  ... |.. .|..||   .. ||..    | . .|.||.|. ..|. . 
ktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1545-1802 5.8e-53 174.9 In-house 26-279 (439) alignment 
Range on Protein: 1545-1802
Range on HMM: 26-279/439.0
FEKLNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGL
|||.||..     .   |.   ...|||| |. ...  || |  .|||  | |||| |..||   . .| ||||  .|.|||||...|.... ||||. |
fekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnl

VEDGKdqsvqYWPKDQLTQYGDMFIETISETDTGFYVIREITITHT-KQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGGPVVVHDS
||  |     ||| |. . |||. . .  . .   |||| . .     ...  | . ||||. | ... |  .  ..|..  .. |      |||||| |
vesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcs

SSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
. |||.||   ..| .|.||.|  .||   .. ||...  .| .  |. | |....| .
agvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1243-1499 5.9e-53 174.9 In-house 15-276 (307) alignment 
Range on Protein: 1243-1499
Range on HMM: 15-276/307.0
DHLFSEEYELITIKSPS-LPHEASQqtCNIEKNRYGNINSFDETRVVLtKIPGIeGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCI
 . . .|.. .. |.|  .. || .  .| .|||| ...  | .|.|. |..|.  |||| |||.        .|..|||| .|  .|| |. ..|  ..
vqalvdefrvlakktpegvtveafs..antdknryqdvkcqdkgrivv.kfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLTNCVEKGRPKCHQYWPQT--GSTTFGELTVTII----DQQVLA----YYTIRTFKINNkDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSt
.|| ...| .. ||.||||       .||| . ||       . ||    .  . |.|..   ..|  .... .. ||| |||.     | ..  |.   
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltainlleavryd.

hTGPLVVHCSAGVGRSGTFIAIQSMM-LMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVEL
 | |.||||||||||||| .||  ..  |.. .   |. ..| ..| .|.| .||||||...|  |.| 
.tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_PTPN1_pd Subfamily PTPN1 1561-1801 7.6e-53 174.1 In-house 26-270 (290) alignment 
Range on Protein: 1561-1801
Range on HMM: 26-270/290.0
SASLPVNRAKNRYPDILPYESYRVRLLMlpgvSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQ
.| || ||..||| |. ||.  |..|      .  |||||| |.      ..|.|||||.|||| ||.|.||..  |.|||  .|| .. . .||||...
eaklpenrnlnryrdvspydhsrikler....adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

L-----TQYGDMFIETISETDTGFYVIREITITHTKqGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFG-GGPVVVHDSSSVGRSGTFCI
       .   . .. ||| .. .|..| . ..  |  .| |.| .|||| |..   | . .|.....  |...  |    ||.|.| |. .|||||||.
eekellledtklkvkliseerksyytvrllelenlk.tqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

INIVIERLKVEGM---IDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEY
.. .. ... ..    .||  .. .||.   |..   ||..| |..|.| 
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
0036282 (Phosphotyrosine protein) phosphatases II 1297-1494 1.2e-51 170.1 In-house 1-164 (174) alignment 
Range on Protein: 1297-1494
Range on HMM: 1-164/174.0
GSDYINANYIDGYGSRDTYIACQGPLAetspdFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQtgsttfgeltvtiidqqvlayytirtfkinNKDDE
|||||||...|..   . .||.|||||     ||.|..|.. ...|||....|.|. ||..|||                               ...|.
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

SFEVKQFHYTAWPDFGVPDHPNpIISFIRRVNNS---THTGPLVVHCSAGVGRSGTFIAIQSMMLMMEtEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVH
. .. |..|. |||.|||| .  ...|...|..     . ||..|||||||||.||..|.  |. ... |. ||....|  .| .| .||||. ||.|..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

D
.
y
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1543-1804 1.2e-51 170.2 In-house 14-279 (287) alignment 
Range on Protein: 1543-1804
Range on HMM: 14-279/287.0
KQFEKLNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVrLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLC
|....|     . .  . .|    .  |||| |.||..  || ||   |  ||||||| || .| . ..|| .|||.. || ||||...|.|....... 
kevdalkedsesstatfkaaeelaavkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmt

GLVEDGKDQSVQYWPKDQL-TQYGDMFIETISETDT-GFYVIREITITHTkQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLV----QKAHHLFGGG
  ||... .  .|||. .   . |   .  .. .     | .| . . .  ...| | .||... .| ..  .||. .|. ... |    . |    . |
reveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidl.etrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG

PVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLES
|.||||.  .||||..  . ....||.  | .|.  ..  || .  ..|    |... |...| | ..
PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1225-1499 1.7e-51 169.6 In-house 8-282 (290) alignment 
Range on Protein: 1225-1499
Range on HMM: 8-282/290.0
SISVSMFPDYVKRLHANTDHLFSEEY-ELITIKSPSLPHEASQQTCNI--EKNRYGNINSFDETRVVLTKipGIEGsDYINANYIDGygSRDTYIACQGP
|. .  |  .       . . .. || | .    |. . | .    |   .|||| ..   | |||.|    | .| ||. |||..|   . ..|  ||.
svqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd..GydG.dyvhanyvkG..lkamfiltqGa

LAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTG--STTFGELTVTIIDQQV-LAYYTIRTFKINNKDD-ESFEVKQFHYTAWPDFGVPDHP
|..|  |.|||. ..|.. |||| . .|.|..||.||.|..     ||||.||.   ..   |    .|. . .||.  .  .| ..  .|||  |.   
lkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst

NPIISFIRRVNnsTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVEL
  ..  .| .   . .||.|||||||.||.|||.||.  . ..    ..|. . |  .|. |   || . ||. . . |..|
lallrtlrilr..kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_PTPN14_pd Subfamily PTPN14 1556-1803 1.9e-51 169.9 In-house 38-297 (300) alignment 
Range on Protein: 1556-1803
Range on HMM: 38-297/300.0
PSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVsGSDYINASYVDGYLRCN--QFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSV
 ... .|.||.|  |||..|.||||  ||.|        ..||||| .   .  .  ..|..|||| .|| |||.|.||. |. ||||    ||||..|.
dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

QYWPKD----QLTQYGDMFIETISETDTGFYVIREITITHTKQGnEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQ----KAHHLF----GGGPVVVH
.|.||.    .  ..|   . |   .|.. .. . ... |   . | |..  . ||||.... |.     .. .  ||    |...         ||.||
kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk.eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvh

DSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLE
 |  |||.|   . ...|. |. .  |||  ... ||..   .|..  |.|| |.....||.
CsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN13_pd Subfamily PTPN13 1561-1804 2.4e-51 169.6 In-house 31-271 (273) alignment 
Range on Protein: 1561-1804
Range on HMM: 31-271/273.0
SASLPVNRAKNRYPDILPYESYRVRLlmlpGVSGSdYINASYVDGYLRCNQ--FIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPK
..    |..|||| ..|||.  ||.|    | .|. |||||..   .  ..  .|..|||| .||.|||.|.|| ... |.|.   .|.|| .  .|||.
vgkkkenkdknryrnvlPydetrvkl....gdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPe

D---QLTQYGDMFIETISETDTGFYVIREITITHTkQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlfGGGPVVVHDSSSVGRSGTFCII
    .|. .. . .| .  ..   .|.|....... . .|.|.. ......| . ..| ..  |. ..  |.. ..    ||.||| |. .|||||.  |
sknkklkvsnrlevellkvqkldgfvvralavkds.esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtliti

NIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLES
..|.. .. .  .|.  ... ||..  |.|   ||. |.|..|.| |.|
dvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1544-1800 5.2e-51 168.2 In-house 11-264 (283) alignment 
Range on Protein: 1544-1800
Range on HMM: 11-264/283.0
QFEKLNSIDVAIPSQYIsASLPVNRAKNRYPDILPYESYRVRLLMLPGvsgsDYINASYVD---GYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVM
..|.|. . |   .  | ||   |. |||. .|.|.. .||.|  ..     |||||...     | . ...|..|.|| .|| |||.|.......||||
frevlkrlsvpdldadi.asadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm

LCGLVEDGKDQSVQYWPKDQLTQYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGAL--MDMIVLVQKAHHlfgGGPV
|  | || . .  |||||.   .||.. .    ||    ..|.|... .    ..   .  . . || |    .   .|  .. ..  |. ..    ||.
ltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtesk...kgPi

VVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVE
||| |. .||...|. .   .. .. | ..|.| ... .| . ...| . ||.|. .. ..|
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1566-1800 7.7e-51 167.6 In-house 2-237 (237) alignment 
Range on Protein: 1566-1800
Range on HMM: 2-237/237.0
VNRAKNRYPDILPYESYRVrLLMLPGvSGSDYINASYVDGYLR-CNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPK-DQLTQ
 |..|||| .|  |.  || .|  .| ||||||||.|..|.    ...| .|||| .. ||||.|.|. . | |||| ||.|  . .  .|||. || . 
enkiknrygnivaydhsrv.vlkgag.sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMI-VLVQKAHHLFGGGPVVVHDSSSVGRSGTFCIINIVIERL
|| . .    . .   | .| .....  . .||| |.|...| | ..  |  | ||. .   ......|.   || ..| |. |||.| | .|. .. . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVE
| . ..||.  ....   .| |.   ||. | .|||.|
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPRN_pd Subfamily PTPRN 1543-1802 8.5e-51 167.4 In-house 33-292 (297) alignment 
Range on Protein: 1543-1802
Range on HMM: 33-292/297.0
KQFEKLNSIDvAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYV-DGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVML
|..| | . . | ||    |. . |  |||. ..|||.  ||.|      . ||||||| . |   |   .| |||||..|| |||.|.||. |  ||.|
kewealcaye.aepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

CGLVEDGKDQSVQYWPKDQLTQYGDMFIETISET-DTGFYVIREITITHTkQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLfGGGPVVV
. | |.|  |  .|||..    |.   .. .||   .  |..| . .    | .| | . |||.  | |. .|... .|...   |.|..      |.||
trleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknl.qtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivv

HDSSSVGRSGTFCIINIVIERLK-VEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
| |. .||.|....|..|..||.     |||  |.  || . ||.|.  |||.|......| .
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
0043147 (Phosphotyrosine protein) phosphatases II 1296-1493 2.7e-47 156.0 In-house 3-154 (172) alignment 
Range on Protein: 1296-1493
Range on HMM: 3-154/172.0
EGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCvekgrpkchqywpqtgsttfgeltvtiidqqvlayytirtfkINNKDD
||||||||.|.|.|   | .||.|||| .| .|||||..|.. ..||.||..                                           .....
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpel

ESFEVKQFHYTAWPDFGVPdHPNPIISFIRRVNN---STHTGPLVVHCSAGVGRSGTFIAIQSMMlmmeteGKVDVFNFVLDMRHKRNYMVQTEAQYMFV
.. .. |..|. |||.||| ... ...|.. ...       || .|||||||||.||..|.  |.       ...... |  .|.||...||.. ||.|.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl

H
.
y
0046846 (Phosphotyrosine protein) phosphatases II 1292-1499 7.1e-47 154.7 In-house 6-172 (176) alignment 
Range on Protein: 1292-1499
Range on HMM: 6-172/176.0
IPGIEGSDYINANYIDGYgsrdTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTTFgeltvtiidqqvlayytirtfkin
.   ...||||||.|.|.     .||.|||| .| .||..|..|.. ...|.||..||.|| ||..|||.  .  .                        
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

nkddesfevkQFHYTAWPDFGVPDHpNPIISFIRRVNNSTHTG-PLVVHCSAGVGRSGTFIAIQsmmlMMETEGKVDVFNFVLDMRHKRN-YMVQTEAQY
          |.... |||.||||. . ...... ...  . | | .||||||.||.||..|.     ..|.|  ..|.. .  .| .|  ..|||..||
..........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQy

MFVHDSLVEL
 |... . .|
rflyefelll
0049772 (Phosphotyrosine protein) phosphatases II 1244-1503 2.4e-46 154.3 In-house 20-283 (314) alignment 
Range on Protein: 1244-1503
Range on HMM: 20-283/314.0
HLFSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDeTRVVLtKIPGIEGSDYINANYIDGYgsrDTYIACQGPLAETSPDF----------WRMI
 |...   .  .  |.| . .... .|..|||| .|  .| .||.| .  ...|||||||.|.||.    ..||.|||| .|  ||          |||.
klllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmv

--WEQKTSCIVM---------------------LTNCVEKGrpkchqywPQTGSTTFGELTvtiidqqvlayytirtFKINNKDDESFEVKQFHYTAWPD
  .....  |||                     |... ..|        ..    .. .|                   ...... . .. ..... .||
lrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........neptaadlellk................eelydpelferlgikylripvpD

fGVPDHPNPIISFIRRVNNSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMetegKVDVFNFVLDMRHKRN-----YMVQTEAQYMFVHDSLVELIKVG
 | .. .. . .|.. ...    ||..|||.||.||.|||...  .|. .    .|..   . |.| ||       ....  || |... | |..|  
.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1246-1499 3.4e-46 152.4 In-house 8-258 (267) alignment 
Range on Protein: 1246-1499
Range on HMM: 8-258/267.0
FSEEYELITIKSPSLPH-EASQQTCNIEKNRYGNINSFDETRVVLTKipgiEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVML
. .|.|||.  |.       |  . | |.||. .   .|.|||.| .    .  .|||| |..||  . ..|. |.||  |  ||. .| .|| . ||.|
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TNCVEKGRPkchQYWP-QT-GSTTFGELTVTIIDQQVLAYYTIRTFKINNKDDESFEVKQFHYTAWpDFGVPDHP--NPIISFIRRVNNSTHTGPLVVHC
|.  .   .   ..|| .   .  . .|||    ..    | | |.... |.. ...|  ..|  | .  . ..|  .|..  . . .      ||||.|
tkvftdnir...lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkw.nintnnkpylkplfgilaknqlengnrPlvvac

SAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVEL
|.||||||||. |.|..  . ||| .|.|.|.. .|..|  .|.|  .|...|..|.| 
sdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0051429 (Phosphotyrosine protein) phosphatases II 1593-1805 1e-45 151.9 In-house 2-228 (272) alignment 
Range on Protein: 1593-1805
Range on HMM: 2-228/272.0
SGSDYINASYVDGYLR---CNQFIMTQGPLSNTVDDFWRMiWEHRVSAIVMLCGLVEDGKDQSVQYWP------------KDQLTQYGDMFIETISETDT
. |.||||..|.|| |    . .. ..||| .|..||||. .|.....||.|....| |...  .|||             ..   ||.... ..||. .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

GFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTgaLMDMIVLVQKahhlfgGGPVVVHDSSSVGRSGTFCIINIVIERLKVEGMID--------
 .|..||...|.. . .|.| . ..|||||    .|. .  | ... |...      ||||.|| |. ..|.||.. . ......  | ..|        
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESF
.. ... ||.. ||.| ...|..|.|. ..|.|.|.
leeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1558-1802 1.9e-45 149.9 In-house 36-236 (392) alignment 
Range on Protein: 1558-1802
Range on HMM: 36-236/392.0
QYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGkdqsvqywp
.  .|  ..|  |||| .||||.| ||.| ..  .. |||.||||....   . .| .||| . ..||||||.....|..|.|.  | |           
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

kdqltqygdmfietisetdtgfyvireitithtkQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGgGPVVVHDSSSVGRSGTFCIINI
                                  .|...| . |||.|.| ..  |  | .|. .|  |.  .  .   |...| |. |||.|    |. 
..................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt.hpliihcsagvgrtgvvisids

VIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
|. . |   |.|.|  .  .|||.| .|   .|. | | ...| |
vvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1543-1803 6.6e-45 148.2 In-house 10-260 (267) alignment 
Range on Protein: 1543-1803
Range on HMM: 10-260/267.0
KQFEKLNSIDVAipSQYISASLPV-NRAKNRYPDILPYESYRVRLLmlpgVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVML
|.||... |     |. || |..  |...||. | |||.  || |      .  .|||||||.|| . |.||.||.||.||. ||. .| ...|. ||.|
kefelikkisdt..sstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

CglvEDGKDQSVQYWPKD--QLTQYGDMFIETISETDTGFYVIreITITHTKQGNEVRNIKQFHYTDWSENKTppTTGALMDMIVLVQKAHHLFGGGPVV
      ..|.  ..||    |  .| |. .|   | .   | |  ||.    . .  .|.  ..|  |  |        |  .. .. | .   |. |.|
t...kvftdnirlfwPPkmgqakkyqdltvehslekeendyqi..itlelkfknesahnvtlyyykkwnintn..nkpylkplfgilaknqlengnrPlv

VHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLE
|. |  ||||||| .|.  .||.| ||. |||  .  .| . .|.|   ... .......|| |
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
0049260 (Phosphotyrosine protein) phosphatases II 1305-1494 5.5e-44 144.8 In-house 1-144 (152) alignment 
Range on Protein: 1305-1494
Range on HMM: 1-144/152.0
YIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWpqtgsttfgeltvtiidqqvlayytirtfkinnkddesfevkQFH
.||||.    .||.|||. .| .|||||..|.. ..|||||...|.|..||.||.                                          |..
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

YTAWPDFGVPDHPNPIISFIRRVNN--STHTGPLVVHCSAGVGRSGTFIAIQSMMlmmeteGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHD
.. |||.||||..  .. ... ..       || .|||||||||.||..|.  |.       .|.....|  .| ||...|... |..|...
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1565-1800 2.6e-43 142.9 In-house 5-238 (239) alignment 
Range on Protein: 1565-1800
Range on HMM: 5-238/239.0
PVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRC-NQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPkDQLTQ
 ||.||||| .|. |.  || |  |     ||||||||.  |    . .| ||| .. .  |||||.|. |   |||| ||.|  | .  |||| |  ..
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstsk

YGDMFIeTISETD-TGFYVIREITITHTKQGNEvRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKaHHLFGGGPVVVHDSSSVGRSGTFCIINIVIERL
| .. . |. .|.    |.|| . ...  | .| | . |.|.| | ..  |  . |.. .   . |   | |  | |.| |. |||.|.| .|. .. . 
ycnlrv.tlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqa

KVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVE
| .  .|||  ..|.|  .| .|   .|. | . ...|
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1565-1799 3.2e-43 142.6 In-house 6-238 (239) alignment 
Range on Protein: 1565-1799
Range on HMM: 6-238/239.0
PVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRC-NQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPkDQLTQ
 ||.||||| .|. |.  || |  |     ||||||||.  |    . .| ||| .. .  |||||.|. |   |||| ||.|  | .  |||| |  ..
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstsk

YGDMFIeTISETD-TGFYVIREITITHTKQGNEvRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKaHHLFGGGPVVVHDSSSVGRSGTFCIINIVIERL
| .. . |. .|.    |.|| . ...  | .| | . |.|.| | ..  |  . |.. .   . |   | |  | |.| |. |||.|.| .|. .. . 
ycnlrv.tlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqa

KVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIV
| .  .|||  ..|.|  .| .|   .|. | . ...
kkqktvdifnyvkairedrphmvqtseqyvfihlavl
0041856 (Phosphotyrosine protein) phosphatases II 1567-1803 3.4e-43 142.7 In-house 1-172 (182) alignment 
Range on Protein: 1567-1803
Range on HMM: 1-172/182.0
NRAKNRYPDILPYESYRvrllmlpgvsGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCglvedgkdqSVQYWPkdqltqygd
|. ||||.|||||.  |          ..|||||....|.|. ..||.||||| .|| ||.||..|.....||.|.         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

mfietisetdtgfyvireitithtkqGNEVRNIKQFHYTDWSENKTPPtTGALMDMIVLVQKahhlfGGGPVVVHDSSSVGRSGTFCIINIVIERlkveG
                           .. |.. |..|. |  . .|. .  | |.|  |..      ||||.|| |  |||.||.... .....    |
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g

mIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLE
 .... ... .|.. ||.| . .|. |... . |.|.
.vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_ptpA1_pd Subfamily ptpA1 1237-1459 6.8e-42 138.7 In-house 14-255 (418) alignment 
Range on Protein: 1237-1459
Range on HMM: 14-255/418.0
RLHANTDHLFSEEYELITIK-SPSLPHEAsQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRdTYIACQGPLAETSPDFWRMIWE
. | .  |   ||. |.     ||   |  ..  |  |||| ||   . ||| | ||   |||||||||||||   .  .|. |||| .|  |||||.||
knhikcihkikeefrlleesvgpsetseg.dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwe

QKTSCIVMLTNCVEKGRPKCHQYWPQ-----------TGSTTFGELTVTIIDQQVLAYYTIRTFKINN-KDDESFEVKQFHYTAWPDFGVPDHPNPIISF
..   ||||.   |. | || .|||.            |   ||  .| ...        | | .|    . |. .. |..|  |||. .||| .|.  .
nrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrql

IRRVNN--------STHTGPLVVHCSAGVGRSGTFIAIQSMMLM
.. . |        | .  |..|||||||||.||| .   ||  
lhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk
0049772 (Phosphotyrosine protein) phosphatases II 1559-1807 1.5e-41 138.5 In-house 38-285 (314) alignment 
Range on Protein: 1559-1807
Range on HMM: 38-285/314.0
YISASLPVNRAKNRYPDILPYEsYRVRLlMLPGVSGSDYINASYVDGYlrcNQFIMTQGPLSNTVDDF----------WRMI--WEHRVSAIVM------
.  |.|..|| ||||.||||..  ||.|    .||||||||||||||.   ..|| |||||..||.||          |||.  ....|  |||      
ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LCGLVEDGkdqsvQYWPKDQLTQYGdmfietisetdtgfyvireiT-------IthtkqgneVRNIKQFHYTDWSEnKTPPTTGA
               |..| . |      ...   | ..                     .                 |.. ........   ..|..  
adelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelf........erlgikylripvpD.gsaplled

LMDMIVLVQKAhhlFGGGPVVVHDSSSVGRSGTFCIINIVIERLkveGMiDIFFTIHALRRKHP-----GIVANYDQFKFCYQTIVEYLESFDK
. ... ....|     ||||.|| .. .||.|||... ... .|   |. ..  ... .|.|.|     | . ...|. |... . |||. . |
fdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1246-1498 1.6e-41 136.8 In-house 13-267 (281) alignment 
Range on Protein: 1246-1498
Range on HMM: 13-267/281.0
FSEEYELITIKSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLT-KIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVML
| .|.  .    ||    . .|  | .|||| ||  .| .|| |  |.|  . .||| ||||     .  ||  |||  ||  |||||||...|..||||
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TNCVEKGRPKCHQYWPQTGS--TTFGELTVTIIDQQVLAYYTirTFKIN-NKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNstHTGPLVVHCS
 . .|  | || .|.|.       | .|.|.  |  |       | ..|   . |.  . .. .  |||. ||.  . ..  .|..    .. | |.|||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslv..ttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira..rstppvihcs

AGVGRSGTFIAIQSMMLMMETEGK-VDVFNFVLDMRH-KRNYMVQTEAQYMFVHDSLVE
||||||||..|..  .  . .     |. . |  .|   |   |||  |||..   |..
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0044763 (Phosphotyrosine protein) phosphatases II 1282-1501 7.9e-41 135.0 In-house 2-172 (178) alignment 
Range on Protein: 1282-1501
Range on HMM: 2-172/178.0
FDETRVVLTKIPGIEGSDYINANYIDGYgsrdTYIACQGPlaetsPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSttfgeltvtiidqqvla
.|.|||.|....|.|.||||||..|...     |.....|     .|......|.. ..||.||. .| |..||..|||.  .                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

yytirtfkinnkddesfevKQFHYTAWPDFGVPDHPNPIISFIRRVNNS--THTGPLVVHCSAGVGRSGTFIAIQSMMLMmetegKVDVFNFVLDMRHKR
                    |.... .||.|||| .  .  |.. ...   .. || .||||||||||||..|.  |. .     ...... .  .| .|
...................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerR

NyMVQTEAQYMFVHDSLVELIK
. .|... |. ....   .| |
p.ivpnpgqlrqLyefelrllk
0051082 (Phosphotyrosine protein) phosphatases II 1297-1495 9.8e-41 134.1 In-house 2-148 (151) alignment 
Range on Protein: 1297-1495
Range on HMM: 2-148/151.0
GSDYINANYIDGYgsrdtYIACQGPlaetSPDFWRMIWEQKTSCIVMLTNCVEKGrpKCHQYWPQTGsttfgeltvtiidqqvlayytirtfkinnkdde
 |||||..|..|.     .....||    ..||.....|.. ..||.|.. .| |  .|..|.|..|                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

sFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNsTHTGPLVVHCSAGVGRSGTFIAIQSMMLMmetegkVDVFNFVLDMRHKRNYMVQTEAQYMFVHDS
 .||...... |||.|.|.... ...|.. ... .  ||..||||||.||.||..|.  |.|.      |...  . ..| || ..||.. |..|..  
.ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1255-1500 1.6e-40 133.6 In-house 39-290 (310) alignment 
Range on Protein: 1255-1500
Range on HMM: 39-290/310.0
IKSPSLPHEASQQtcNIEKNRYGNINSFDETRVVLtKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPK
 . .|| .|| ..  .. |||| ..   |..|| | ||      ||| |||.     |.|.| .||||  |  ||||||.....  |..| . .|.||||
kqdssltyeaykk..ymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpk

CHQYWPQTGST-TFGELTVTIIDQQVLAYY---TIRTFKINNK--D-----DESFEVKQFHYTAWPDFGVPDHPNPIISfiRRVNNSTHTGPLVVHCSAG
|  |||  | | |.| . || . .    .       ||  .|   |      . . |.  ..  ||| ||||     .   .|.      || |||||||
cvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaqvrhgpcvvhcsag

VGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
..| .. .|..  .  ..   |||. . . .....|   .||| ||....   . . 
kdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa
0036282 (Phosphotyrosine protein) phosphatases II 1594-1796 1.8e-39 130.6 In-house 1-164 (174) alignment 
Range on Protein: 1594-1796
Range on HMM: 1-164/174.0
GSDYINASYVDGYLRCNQFIMTQGPLSntvddFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKdqltqygdmfietisetdtgfyvireitithtKQG
||||||||..|.. . . .| .||||.     ||.|..|......|||. ..|.|.    .|||                                 .. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

NEVRNIKQFHYTDWSENKTPPTTGaLMDMIVLVQKAHHLFGGGPVVVHDSSSVGRSGTFCIINIVIERLKvEGMIDIFFTIHALRRKHPGIVANYDQFKF
 ..|.. |..|. |  . .|...  | ... .|..|.   .||||.|| |  |||.||.... ... .|. |...|.. ....||.. ||.| . .|..|
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

CYQ
.|.
lyy
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1267-1500 1e-38 127.9 In-house 45-287 (305) alignment 
Range on Protein: 1267-1500
Range on HMM: 45-287/305.0
QTCNIEKNRYGNINSFDETRVVLtkiPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGS--
.. . .|||| ..  .|. || |    |    .|| |||.        .| .| || .|  ||| | ...|   | || | .|||  ||..|..      
eaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

TTFGELT----VTI-------IDQQVLAYYTIRTFKINNKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSthTGPLVVHCSAGVGRSGTFIAI
 .| |      | .       . ..  |  |   . |.    ..  |...|.  ||| |||   . |. .. .   |   ||.|||||||.||.|. . .
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps..kgpivvhcsagigrtgsvvml

QSMMLMMETEGKVDVFNF-VLDMRHKRNYMVQTEAQYMFVHDSLVELI
. ..  . .  ...  .  .  .| .||  .||.|||.|||. ... .
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1542-1805 2.8e-38 126.2 In-house 28-286 (290) alignment 
Range on Protein: 1542-1805
Range on HMM: 28-286/290.0
PKQFEKLNSIDVAIPSQYISASLPV-NR--AKNRYPDILPYESYRVrlLMLPGVSGsDYINASYVDGYlrCNQFIMTQGPLSNTVDDFWRMIWEHRVSAI
    | |. .   .|.||.  ..   |    |||| |.   .  ||  ..  |  | ||. | ||.|      ||.|||.| .|| |.|||. ...|.||
elakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrv..ilkdGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaai

VMLCGLVEDGKDQSVQYWPKD--QLTQYGDMFIETISETDTGFYVI-REITITHTKQGNEvRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHhlfgg
|||| |.|||| .  ||.|.   .   .|.. .    |.|    .| . ... . ..| |   .| ..   | ..  . .| ||. ..  ..||      
vmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGke.hklkhlkikswpdksvalstlallrtlrilrkas.....

GPVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESF
|||||| |. .||.|||  |.. .. |     .|.  .. |||.   . |    |.    . ....  .|
GpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
0043147 (Phosphotyrosine protein) phosphatases II 1593-1796 3e-38 126.6 In-house 3-155 (172) alignment 
Range on Protein: 1593-1796
Range on HMM: 3-155/172.0
SGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLvedgkdqsvqywpkdqltqygdmfietisetdtgfyvireititHTKQ
.|||||||||.|.|   ..||.|||||.||..|||||..|. ...||.|..|                                             .  
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

GNEVRNIKQFHYTDWSENKTPpTTGALMDMIVLVQKAHHLFGGGPVVVHDSSSVGRSGTFCIINIVIerlkvEGMiDIFFTIHALRRKHPGIVANYDQFK
 ...|.. |..|. |  . .| ..  |.... .......|  ||||.|| |  |||.||.... ...     .|. ... ... .|.| ||.| | .| .
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyr

FCYQ
|.|.
flyy
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1267-1498 1.2e-37 124.3 In-house 52-287 (305) alignment 
Range on Protein: 1267-1498
Range on HMM: 52-287/305.0
QTCNIEKNRYGNINSFDETRVVLTKIPgieGSDYINANYIDGYGS-RDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGST
   .| |||| ..   |.. | | | .    |||| |||.         .|..|||| .|  .|| |. ..|   |||| . || |. || |||| .   
adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

TFgELTVTIIDQQV--------LAYYTIRTFKINNKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSThtGPLVVHCSAGVGRSGTFIAIQSMM
   ||   |. ..|         |   | .....   |... |.....| ||| |||      . ..  .  |    |.|||||||.||.|| .||. ..
kl.elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk..vpivvhcsagigrtgtivaieyil

LMM-ETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVE
  . |      . ..|  .| .| . .|.. ||.|.|  ...
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
PTPc_DSPc_SM00012 1400-1497 3.4e-36 119.0 In-house 2-104 (105) alignment 
Range on Protein: 1400-1497
Range on HMM: 2-104/105.0
VKQFHYTAWPDFGVPDHPNPIISFIRRVNNSTH----TGPLVVHCSAGVGRSGTFIAIQSMMLMMETE-GKVDVFNFVLDMRHKRNYMVQTEAQYMFVHD
||..|||.|||.|||.....|....| |.....    ..|.||||||||||.|||.|.  .. ..|.| ..||.|..|  .|..|. |||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

SLV
 | 
all
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1268-1508 3.6e-36 119.6 In-house 33-279 (285) alignment 
Range on Protein: 1268-1508
Range on HMM: 33-279/285.0
TCNIEKNRYGNINSFDETRVVLTKipgiEGSDYINANYIDGYGS-RDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTG--S
 .| . ||| ..   .|||||| .       ||| |...   |  . |||. |||| ||  |||.||...| . ..||   .| |  ||  |.|.     
eanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

TTFG--ELTVTIIDQQVLAYYTIRTFKINNKDDESFEV---KQFHYTAWPDFGVPDHPNPIISFIRRVNNS-THTGPLVVHCSAGVGRSGTFIAIQSMML
  ||  |.|.|   .. .|   . .. . | .| | |    .. .   |||   |.   |.| . . |..   .  |..|||||||||. ||. |.   .
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyati

MMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVEL-IKVGNSEQT
 .  . ...... | .||  |   ||.  |..|..  |.|  |  |  |.|
rimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvvert
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1269-1498 5.2e-36 119.2 In-house 42-269 (288) alignment 
Range on Protein: 1269-1498
Range on HMM: 42-269/288.0
CNIEKNRYGNINSFDETRVVLTkipgIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQ-TGST-T
 |  ..|| |.   | ||| |.     .   ||.|| .     .   | .| ||  |   .|.|. |.    ||||.. .|||..|  .|.|   | .  
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FGELTVTIIDQQ--VLAYYTIRTFKINNKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVnnSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEG
.| |   . ...  .    .. ...|... .|.  ||. |.  |.| |||.   . . .. ..   ... |.|||.||||||.||.| |  .. ..  . 
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqkPivvhssaGvGrtgtlililialeslrldd

KVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVE
 . . ...  .| .|   .||| ||..||  . |
flgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_CG42327_pd Subfamily CG42327 1268-1430 2.4e-35 116.7 In-house 27-193 (319) alignment 
Range on Protein: 1268-1430
Range on HMM: 27-193/319.0
TCNiEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGS-RDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQT----
|.. .|.|. |.  . |||||| .|.  . . |..|.|. || . .  |||.| .| ..| ||||..|||..  || ||.  |.|  .| .|.|      
tsk.dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

GSTTFGELTVTIIDQQVLAYYTIRTFKINNKD-DESFEVKQFHYtAWPDFGVPDHPNPIISFIRRVNNS
.  ..|.. ||. ...|   | | |. ... | .|| |.  . |  |.. .|| .....|. . .|..|
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
0049260 (Phosphotyrosine protein) phosphatases II 1602-1796 1.2e-33 111.3 In-house 1-144 (152) alignment 
Range on Protein: 1602-1796
Range on HMM: 1-144/152.0
YVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWpkdqltqygdmfietisetdtgfyvireitithtkqgnevrnikQ
..||| . ..|| ||||..||..|||||..|. ...||||. |.|.||..  ||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

FHYTDWSENKTPPTTGALMDMIVLVQKAhHLFGGGPVVVHDSSSVGRSGTFCIINIVIerlkveGMIDIFFTIHALRRKHPGIVANYDQFKFCYQ
.... |  . .|. .  |.... ...|.  |  ||||.|| |  |||.||.... ...        .... ..  .|.| ||.| | .| .|.|.
ylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 1585-1803 1.5e-33 111.4 In-house 2-174 (176) alignment 
Range on Protein: 1585-1803
Range on HMM: 2-174/176.0
RLLMLPGVSGSDYINASYVDGYLrcnqFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKdqLTQYGDmfietisetdtgfyvire
||..|    ..|||||....|..    .| ||||| .|. ||..|..|....|.|.|. .|| |. .  .|||   |...|                   
rlrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..................

itithtkqgnevrnikQFHYTDWSENKTPPTtGALMDMIVLVQKAHHlfGGGPVVVHDSSSVGRSGTFCIINivieRLKVEGMIDIFFTIHALRRKHP-G
                |.....| .. .|.   .|.... ....| .   ||||.|| |  .||.||....      |. |  .... ... .|...| |
................qylhlpwpDhgvpdl.elllellefirealk..eggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplg

IVANYDQFKFCYQTIVEYLE
.| . .| .|.|. . ..|.
avqtpeQyrflyefellllk
subfamily_ptpA1_pd Subfamily ptpA1 1564-1762 2.6e-33 110.4 In-house 44-256 (418) alignment 
Range on Protein: 1564-1762
Range on HMM: 44-256/418.0
LPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLrCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPK----D
   | .|||| .||| .  ||.|  .    ||||||| |.||    .||| ||||| ||. |||||.|| |.  ||||    |. . .  .|||.    .
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

QLTQYGDM---F-------IETISETDTGfYVIREITITHtkQGnEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQ-KAHHLFG----GGPVVVHDSS
|.. ||.    |       .| | . .    . |.| .|   .| | |.| |..|  | . . |  |  . ...  .  .  ..        |..|| |.
qfsiygngnevfgtysvelveviqdpere.iitrnirltf..eg.etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsa

SVGRSGTFCIINIVIERL
 |||.||||   |....|
gvgrtgtfctavimmkkl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1560-1802 2.6e-32 107.1 In-house 34-277 (307) alignment 
Range on Protein: 1560-1802
Range on HMM: 34-277/307.0
ISASLPVNRAKNRYPDILPYESYRVrLLMLPGVSgSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKD
   ..  |  |||| |.   .  |. .. ..|.. |||| | |.   .. ..|| .|||| ||. .|| |. ...| ...||| ..| .| .  |||| .
tveafsantdknryqdvkcqdkgri.vvkfdgla.sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

Q--LTQYGDMfIETISETDTGFYVIR------EITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQkahhlFGGGPVVVHDSSSVGRSGT
.     .|.   .||| .. |   .       ..|  . . ... | |... ...| .. .|..  . ....  |.     .   ||||| |. ||||||
egqklvfgea.pntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr.....ydtnpvvvhcsaGvGrsGt

FCIINIVIERL-KVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
   | .| ... . .   |.   .. || . .  . .  |. . .. ..||.
ivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1272-1500 5.2e-32 105.8 In-house 52-282 (301) alignment 
Range on Protein: 1272-1500
Range on HMM: 52-282/301.0
EKNRYGNINSFDETRVVLTKipgiEGS-DYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGSTT--FG
.|.|| ..    .| | . .    .|    | ||.|.  |  . .|| |||| .|| ||| |.   .   ||||.. |||   ||..| |.. | .   |
dkhryptvPckPstaveviv....dGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

ELTVTIIDQQVLAYYTIRTFKINNKDD-ESF---EVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSTHtgPLVVHCSAGVGRSGTFIAIQSMMLMMETEG
  ...| .....    |   ... .|  . |    |  . |. |.| |||     .  ..  | .| .  |.|||||||.||| .||. . .   .|.. 
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek..PivvhcsaGiGrsvafigteylareveadp

KVDVFNFVLDMRHKRNYMVQTEAQYMFVH-DSLVELI
.... . . ..|..|   |||. |  ..   ..  ||
tieltealkhlrehrwngvqtnsqlywmtlGtvyrli
subfamily_egg_pd Subfamily egg 1260-1497 1.3e-31 104.4 In-house 30-267 (307) alignment 
Range on Protein: 1260-1497
Range on HMM: 30-267/307.0
LPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKgrPKCHQYW
 . . . .  | || |   ..  | .|| |    |    |.| ||...|    ...| .| || .|  |||||.....   |||||  .|    .|. ||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyyw

PQTGS--TTF--GELTVTI--IDQQVLAYYTIRTFKINNKDDESFEVKQFHYtAWPDFGVPDHPNPIIsfiRRVNNSTHtgPLVVHCSAGVGRSGTFIAI
|.. |    .  | | ..   .|..    ...  .|.   |||   .. . .  .   .    |  ..   |.. | ..  | ||..  || ...|..||
pkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvl...rklrnlsk..pvvvqdilGvskaatlvai

QS--MMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLV
.   . |.     |  | . |  .| .|.. |..  .|.||.  ..
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1561-1809 1.4e-31 104.2 In-house 49-298 (305) alignment 
Range on Protein: 1561-1809
Range on HMM: 49-298/305.0
SASLPVNRAKNRYPDIlPYESYRVRLLMLPGvsGSDYINASYVDGYLR-CNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKD
  |  .. .|||| |. | .   . .|  |    |||| | ||   .   ..|| .|||| .|.|.|| |. ...|  |||||  || || .  ||||  
nqsadiaitknryqdv.pcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa

---QLTQYGDMFIETISETDTgFYVIREITITH---TKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlfgggPVVVHDSSSVGRSGTFC
   .|.  . . .| .| .   .    || ||    |  |..   ......|.| .   ||   . ....  .. ..      |.||| |. .||.||  
qgeklelksgivvenvsgskp.merdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv.....pivvhcsagigrtgtiv

IINIVIERLKVEGMID-IFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL-ESF-DKYA
 |. ..|..  .     .   ..||| .    . |  |. | .. ...|. | . .|||
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekya
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1258-1425 1.5e-31 104.3 In-house 21-191 (297) alignment 
Range on Protein: 1258-1425
Range on HMM: 21-191/297.0
PSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKipGIEGSDYINANYIDGYGS--RDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKC
 .    ....   . |||| .| ..|.||| | .  .| ..|||||.|.          ||  |||| .|  |||....||    |||...  | || ||
rgesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

HQYWPQT--GSTTFGELTVTIIDQQVLAYYTIRTF--KINNKdDESFEVKQFHYTAWPDFGVPDHPNPIISFIR
  |||..  .  . |.. |  . .    . ..     ..  . .||  |.   . .||| |||   . .  |  
apywpsvvqerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqa
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1554-1713 4.9e-31 102.7 In-house 20-180 (297) alignment 
Range on Protein: 1554-1713
Range on HMM: 20-180/297.0
AIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMlpGVSGSDYINASYVDGY--LRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQ
| . .. ||  .    |||| ||| ... ||.||   .....||||| ||         ..|..|||||.||||||....|. | .|||.. | |||.|.
argesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdk

SVQYWPKDQ--LTQYGDMFIETISETDTGFYV--IREITITHTkqgNEVRNIKQFHYTDWSENKTP
 . |||. .    . ||. .| .|.|   |    . |... .    .| | ..   .  | .   |
capywpsvvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvp
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1566-1803 3.8e-29 96.6 In-house 42-272 (288) alignment 
Range on Protein: 1566-1803
Range on HMM: 42-272/288.0
VNRAKNRYPDILPYESYRVRLLmlpgVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPK--DQLTQ
 | ...|| ..   .  ||.|          ||.|  |      ...| .| ||  |.. .|.|. |  |  ||||| |.| ||..| .|.|    . ..
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGDMFIETISETdTGFY-VIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlfgggPVVVHDSSSVGRSGTFCIINIVIERL
.| .   .  .  ..   ...  ..  .|.|.|   .|. |. .| ..  |    . . ..  ... ..     |.||| |  |||.||. .| |..| |
igrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk.....PivvhssaGvGrtgtlililialesl

KVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLE
...  . |   .. || ..   .    |. . .. . |.| 
rlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1568-1803 4e-29 96.3 In-house 49-288 (305) alignment 
Range on Protein: 1568-1803
Range on HMM: 49-288/305.0
RAKNRYPDILPYESYRVRLlmlPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQ---LT-Q
. |||| |.   .  ||.|    |    .|| | ||      ..|| || || .|  ||| | ....| || ||| |.| |  . ..|.. ..   |. .
agknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

YGDM--FIETISETDTGFY-----VIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTgalMDMIVLVQKAHHLfgGGPVVVHDSSSVGRSGTFCIIN
 ..    .   | .   |      ...|  ..    |...| ....|. || .   |..    . .. |..||  .   ||.||| |. .||.|.  ...
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaad...lailellekarps..kgpivvhcsagigrtgsvvmle

IVIERLKVEGMIDIFF-TIHALRRKHPGIVANYDQFKFCYQTIVEYLE
 ....|    .|.     .  .| .    .   .|. | .| |..|..
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1563-1765 5.6e-29 95.7 In-house 33-230 (281) alignment 
Range on Protein: 1563-1765
Range on HMM: 33-230/281.0
SLPVNRAKNRYPDILPYESYRVRLLM-LPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQL
  |||  |||| .|   .  ||.| . .|    .||| | |.   .    .|.||||  .|  |||||||.   .|||||| ..|  ...  .|.|..  
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

--TQYGDMFIETISETDTGFYVIREITITHtkqGNEVRNIKQFHYTDWSENKTPPTTGALMDMIvLVQKAHhlfgGGPVVVHDSSSVGRSGTFCIINIVI
   |.  . ..    |     |   . ...     | | | .. . .| . . | ..  .. ..    .|.      | |.| |. ||||||.  ..| .
cclqfdklsvsyedstvnkslvttrlnlsy...egetrlithwlwkewpdwqvpessevmlkil.rkirar....stppvihcsagvgrsgtlmaveial

ERLKVE
. ..  
qsihsh
0044763 (Phosphotyrosine protein) phosphatases II 1578-1799 1.2e-28 95.4 In-house 1-168 (178) alignment 
Range on Protein: 1578-1799
Range on HMM: 1-168/178.0
PYESYRVRLLMLPGVSGSDYINASYVDGYlrcnQFIMTQGPlsntvDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQLtqygdmfietisetdt
|.. .|| | .|.|. .|||||||.....     ......|      |......|. ...||.|.. .| |. .. .|||..                  
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

gfyvireitithtkqgnevrniKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlFGGGPVVVHDSSSVGRSGTFCIINIVIERlkveGMiDIFFTIHAL
                       |.... .. ...|. .  ..... ....|..   ||||.|| |  ||||||.... .....    |. ...  |. .
......................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RRKHPgIVANYDQFKFCYQTIV
|.. | || | .| ...|.   
rerRp.ivpnpgqlrqLyefel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1541-1781 1.1e-27 91.5 In-house 29-269 (310) alignment 
Range on Protein: 1541-1781
Range on HMM: 29-269/310.0
LPKQFEKLNSIDvaiPSQYISASLPVNRAKNRYPDILPYESYRVRLLMlPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVM
| ||. ||.. .    |     .   .  |||| |..  .. ||.| .       ||| | ||      . || .||||  |. ||||||.. |  .|..
lvkqyrkldakq...dssltyeaykkymhknrysdvvcldtsrvklki.dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesill

LCGLVEDGKDQSVQYWPKDQLTQ-YGDMFIETISETDTGFYVIrEITITHTKQ-------GNEVRN--IKQFHYTDWSENKTPPTTGALMDMIVLVQKAH
||  .|.|. ..| |||   .|. || . .  .||.   | .  ....|   .         ....  ..  .. .| .   |      .   .| |  |
lckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeic.nlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh

hlfggGPVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKH
     ||.||| |. ..| .. . ... |..|.    .|.   .  |....
.....gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksr
0051082 (Phosphotyrosine protein) phosphatases II 1595-1798 3.7e-27 90.2 In-house 3-149 (151) alignment 
Range on Protein: 1595-1798
Range on HMM: 3-149/151.0
SDYINASYVDGYlrcnqFIMTQGPLSntvdDFWRMIWEHRVSAIVMLCGLVEDGkdQSVQYWPKDQltqygdmfietisetdtgfyvireitithtkqgn
|||||.|||.|.     .. ..|||.    ||.....|. ...||.|....| |     .|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

evRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKahhlFGGGPVVVHDSSSVGRSGTFCIINIVIERlkvegmIDIFFTIHALRRKHPGIVANYDQFKFC
  .........||.. ..| .. |..... |...     ..|||.|| |. .||.||.... .....      .... ... .|.|.||.|   .|| |.
..ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YQTI
.. .
lfal
0048076 (Phosphotyrosine protein) phosphatases II 1374-1497 2e-26 87.8 In-house 19-140 (145) alignment 
Range on Protein: 1374-1497
Range on HMM: 19-140/145.0
IIDQQVLAYYTIRT---FkINNKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSTH-TGPLVVHCSAGVGRSGTFIAIQSMMLmmetEGkVDVF
 .| . |. . |.|   .  ....... .. |..|. |||.|||| .. ...|.. ...     || .|||||||||.||..|.  |.|    .| |...
aldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll....lg.vsle

NFVLDMRHKRNYMVQTEAQYMFVHDSLV
. .  .| .| ..|... |. |... . 
ealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1273-1501 3e-26 86.9 In-house 46-277 (312) alignment 
Range on Protein: 1273-1501
Range on HMM: 46-277/312.0
KNRYGNINSFDETRVVLTkipGIEgSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGS-------T
 ||| ||. .|  |  |.   | |   || ||..      . ....|||| .|.  ||..     ...|..|.  || |  || .|  .  .        
lnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

TFGELTVT-IIDQQVLAYYTIRTFKINNKDDE-SFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNSthTGPLVVHCSAGVGRSGTFIAIQSMMLMMETE
 . |      |  .     | | .|.  |       .... ...||| |.||  .    ..  |..     |.. ||||||||.||.. |.||.  .   
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkd..kkpviahcsagvgrtgtlaliesmiaalrhp

GKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
 | .| .  . .|. |   |.. .||...  ...|.. 
rkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1396-1505 1.4e-25 84.5 In-house 87-199 (440) alignment 
Range on Protein: 1396-1505
Range on HMM: 87-199/440.0
ESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNST---HTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFV
||  .||.|| .||| |||    |.. .|. ||.|      |||.||||||.||.|  ||..|..   .   ..|.|.|.  || .|  ||||  || ||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDSLVELIKVGNS
|....| . .|..
heavlegllcgdt
0048179 (Phosphotyrosine protein) phosphatases II 1394-1494 3.8e-25 83.7 In-house 43-139 (144) alignment 
Range on Protein: 1394-1494
Range on HMM: 43-139/144.0
DDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNNS-THTGPLVVHCSAGVGRSGTFIAIQSMMlmmeTEGkVDVFNFVLDMRHKRNYMVQTEAQYMFV
... .|. |.... |||.||||... ...|.. ...   . || .|||||||||.||..|.  |.    ..| ..... .  .| .| ..|... |..|.
efleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfL

HD
..
le
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1280-1514 4.9e-25 83.2 In-house 28-272 (290) alignment 
Range on Protein: 1280-1514
Range on HMM: 28-272/290.0
NSFDETRVVLTKIPGIEGSDYINANYIDgYGSRDTYIACQGPLAET-------SPDFWRMIWEQKTSCIVMLTNCVEKGRP----KCHQYWPQTG--STT
  . .|||||        .||| ||..  . .    |. | |....         .|| |. . |   .||| .  || .      | .| |..   . .
pLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelk

FGELTVTIIDQQVLAYYTIRTFKINNKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRVNnsTHTGPLVVHCSAGVGRSGTFIAIQSMM-LMMETEGK
|. |||   ..       .|.  ..  |.| | |.   .  | .  |....  ..| |. |.  ... | .|||  |. || .. ||.  . ...||.|.
fkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgs

VDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVeLIKVGNSEQTVQNFPK
| . . . ..|..|. ..... .. ||   .| |  .   .|.... ..
vkledvlkalrkqralaitsalelafvdagiv.llaievldqfaeeete
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1318-1492 4.3e-24 79.5 In-house 96-280 (302) alignment 
Range on Protein: 1318-1492
Range on HMM: 96-280/302.0
CQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQ--TGSTTFGELTVTII----------DQQVLAYYTIRTFKINNKDDESFEVKQFHY
   |  .|   .| .| . ... .| |.. ||..  || .|. .   |  .||. ||. .          |.. .  ||.     . |..  . |. ...
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TAWPDFGVPDHPNPIISFIRRVNnsTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFV
.|||| | |..... .  ..  .  ..   ..|||||||||.||..||.  . .  ..   |. . || .|. |   ||.| | ...
sawpdhGapkeaytaldilkfce..sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1568-1780 5.8e-24 79.4 In-house 51-259 (301) alignment 
Range on Protein: 1568-1780
Range on HMM: 51-259/301.0
RAKNRYPDIlPYESYRVRLLMLPGVSgsDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQLTQ--YG
. |.||| . | .      ..  |      | | ...   . ..|| |||||.|| .||| |.  . |  ||||.  ||. ...  .| | .   .   |
kdkhryptv.PckPstavevivdGkr..vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

DMFIETISETD--TGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlfgggPVVVHDSSSVGRSGTFCIINIVIERLK
   |.. ..        . |.. .. . .  . | .  . |..|... .| .   |.|.. ||.|...     |.||| |. .||| .|   ...  ...
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylareve

VEGMIDIFFTIHALRRK
 .  |..  ... || .
adptieltealkhlreh
subfamily_egg_pd Subfamily egg 1566-1799 6.4e-24 79.2 In-house 39-267 (307) alignment 
Range on Protein: 1566-1799
Range on HMM: 39-267/307.0
VNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDgkDQSVQYWPKDQ---LT
 |. | | . .   .| ||.| .  |    |.| | .|.|    |.||..| || |||||||||... .|  ||||   .|   ..   |||| .   | 
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslv

Q-YGDMFIETISETDTGFYVIreiTITHTKQ-GNEvrnIKQFHYTDWSENKTppTTGALMDMIVLVQKAHHLfgGGPVVVHDSSSVGRSGTFCIINIVIE
   | . ||..   ..   .    ..|. |  | .    .. .   |  .     .. .   . ...|. .|    ||||.|   | ...|.  |.| . 
tvpGslrienlkvdskadplf...rvtklklvGgd...deerflehwqgdvn..nssdvysplrvlrklrnl..skpvvvqdilGvskaatlvaieiall

RLkVEGMI---DIFFTIHALRRKHPGIVANYDQFKFCYQTIV
 | . | |    .  ..  ||.. .  |    .. | |. ..
sl.lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1327-1510 6.6e-24 79.4 In-house 42-232 (255) alignment 
Range on Protein: 1327-1510
Range on HMM: 42-232/255.0
PDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQ--TGSTTFGELTVTIIDqqVLAYYTIRTFKINN---KDDESFEVKQFHYTAWPDFGVPDHPNPII
  |...|  .||. .|||..  |.|. ||..|.|    .   . ...||  .    |   .|| .|     .  .  .|| ..|. |..   |. .. | 
dkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

SFIRRVNNSthtGPLVVHCSAGVGRSGTFIAI----QSMMLMMETE--GKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI-KVGNSEQTVQ
  .. | .|    ..|||||.|.||| .|. .    | |.. ..|   ...|  ... ..|.||.  ..|  |  |    ...|.   |. |.  |
nilkvvrds...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleakyq
subfamily_CG42327_pd Subfamily CG42327 1565-1729 2.4e-23 77.3 In-house 25-193 (319) alignment 
Range on Protein: 1565-1729
Range on HMM: 25-193/319.0
P-VNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDGYLRC-NQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPK----
|   . |.|. ...|    || |   .    . |..|||| ||  . |..| .| .| ..  ||||..|| .   || |. | | | ..  .|.|     
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

DQLTQYGDMFIETISETDTGFYVIREITITHTkQGNEVRNIKQFHYtDWSENKTPPTTGALMDMIVLVQKA
|.   |||. .          |.|  . . .  ...| |..  . | .| | . |    ||. |.. |...
dntslyGdilvtlkgrevkdryaistlllkrv.dkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1555-1802 9.4e-23 75.6 In-house 23-270 (285) alignment 
Range on Protein: 1555-1802
Range on HMM: 23-270/285.0
IPSQYISASLPVNRAKNRYPDILPYESYRVRLLmlpgVSGSDYINASYVDGYLR-CNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSV
.| .   ..   |   ||| |.   |  || |         ||| ||..    .  . .| ||||| .|. |||.||.. ... ..||| |.| | ..  
mppnctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekca

QYWPKD--QLTQYGDMFI---ETISETDTGfYVIREITITHTKQG-NEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlfGGGPVVVHDSSSVG
 |.|.   .. ..|   |   |   |. .|  ..  .|.. |..  .|   ... .   | .. .|  .  ....   |.|        |..|| |. ||
lyypeklgevvkfgkyeitlteckeeaiag.tilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp..kekpicvhcsagvg

RSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
|. ||  |.    |.  .  |...  .. .|  .   | .. || | |  ..||.
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
PTPc_DSPc_SM00012 1699-1799 1.5e-22 75.2 In-house 2-104 (105) alignment 
Range on Protein: 1699-1799
Range on HMM: 2-104/105.0
IKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFG-GGPVVVHDSSSVGRSGTFCIINIVIERLKVE-GMIDIFFTIHALRRKHPGIVANYDQFKFCYQ
.|..|||.|.. ..| .. ......  |.| ..  . ..|||||.|  |||.|||. . |....|. | . .||| ....||.. || | ...|. |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TIV
 . 
all
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1436-1503 2.1e-21 70.1 In-house 1-68 (69) alignment 
Range on Protein: 1436-1503
Range on HMM: 1-68/69.0
LVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVG
.|||||.| ||.||||||   |  . .|  ||.|| |  ||  |  ||  | .|.|.||.||| .|.|
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1568-1662 2.6e-21 70.8 In-house 48-156 (350) alignment 
Range on Protein: 1568-1662
Range on HMM: 48-156/350.0
RAKNRYPDILPYESYRVRLL--------MLPGVSGSDYINASYVDGY----LRCNQ--FIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSV
 ||||| .|||||  ||.|         .   .|..|||||.|.           .  .| ||.|| .|||||...| .  |  |..|  .|| . ..  
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPKDQLT
.||.. .  
rYWqegsyd
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1265-1500 3.1e-21 70.3 In-house 42-279 (303) alignment 
Range on Protein: 1265-1500
Range on HMM: 42-279/303.0
SQQTCNIEKNRYGNINSFDETRVVLTKipgiegSDYINANYIDGYgSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGS
 |   |..|||. ..  .| ..| |.       | || |.|..   |.   |  | ||. |. |||.|| |||  |...|    |  .   .  .|.   
nqfvknmdknrfvdvicldhskvklsd......ssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

-TTFGELTVTIIDQ---QVLAYYTIRTFKINNKDDESFeVKQFHYTAWPDFGVPDHPNP-IISFIRRV----NNSTHTGPLVVHCSAGVGRSGTFIAIQS
   | | .. . .    ..   ....   . | |  || ..  || |||   .| . .| ..  | ..     . ... | |    .|.||.|||  ...
flkfeersirvgefkrvelgdgwvlkvlsvsngdyksf.lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfet

MMLMMETE-GKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELI
  | . .|   .|. . .  .|  | . ||  .|. .|.  | | .
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1437-1503 3.6e-21 69.3 In-house 1-67 (69) alignment 
Range on Protein: 1437-1503
Range on HMM: 1-67/69.0
VVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVG
|||||.| ||.||||||   |  . .|  ||.|| |  ||  |  ||  | .|||.||.||| .|.|
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_hpo-7_pd Subfamily hpo-7 1322-1501 3.9e-21 70.1 In-house 43-228 (263) alignment 
Range on Protein: 1322-1501
Range on HMM: 43-228/263.0
LAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQ--TGSTTFGELTVTIIDQQVlaYYTIRTFKINN---KDDESFEVKQFHYTAWPDFGVPDH
| .| . |...|  .||. .|||..  |.|. || .|.|    .   . ...|.  . |      ..| .. .   .  .  .||.. |. |..   |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PNPIISFIRRVNNSthtGPLVVHCSAGVGRSGTFIA----IQSMMLMMETE--GKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIK
.. |.  .. . ||    .||||||.|.|||  |       | |.. ..|   ...|  ... ..|..|.  ..|  |  |    ..... 
areilnilkvarns...kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1269-1363 1.4e-20 68.3 In-house 46-154 (350) alignment 
Range on Protein: 1269-1363
Range on HMM: 46-154/350.0
CNIEKNRYGNINSFDETRVVLTKI--------PGIEGSDYINANYIDGY------GSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPK
    |||| ||  .. .|| | |           ....|||||||.          .   ||| |.|| .|  ||...| . |   |..||. || .. |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CHQYWPQTG
|..||.. .
cyrYWqegs
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1611-1796 9.2e-20 65.7 In-house 6-198 (199) alignment 
Range on Protein: 1611-1796
Range on HMM: 6-198/199.0
QFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQ--LTQYGDMFIETISETDTGFYVIREITITH-TKQGNEVRNIKQFHYTDW
..| || || .|. |||.|.||     |||.     . . .   |||  .   ..|| . . | . |    |.|  . .|  |      |.| .. .| |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

SENKTPpTTGALMDMIVL---VQKAHHLFGGGPVVVHDSSSVGRSGTFCIINIVIERLK--VEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQ
 |. ||     .. ..|    | | .      ||.|| |   | .| |  ..| .   .     ..|.|   . ||.   ||..  ....| ||
kekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1611-1796 9.3e-20 65.6 In-house 5-197 (198) alignment 
Range on Protein: 1611-1796
Range on HMM: 5-197/198.0
QFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQ--LTQYGDMFIETISETDTGFYVIREITITH-TKQGNEVRNIKQFHYTDW
..| || || .|. |||.|.||     |||.     . . .   |||  .   ..|| . . | . |    |.|  . .|  |      |.| .. .| |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

SENKTPpTTGALMDMIVL---VQKAHHLFGGGPVVVHDSSSVGRSGTFCIINIVIERLK--VEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQ
 |. ||     .. ..|    | | .      ||.|| |   | .| |  ..| .   .     ..|.|   . ||.   ||..  ....| ||
kekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1568-1808 1.4e-19 65.0 In-house 44-282 (312) alignment 
Range on Protein: 1568-1808
Range on HMM: 44-282/312.0
RAKNRYPDILPYESYRVRLlmlPGvSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKD-QLTQYGD
.  ||||.|  ..  |  |    |     || | .|    . ..|. ||||| ||.  ||..      ..|..|||.|||| .....|      . .  |
kdlnrypniqcwdrgrftl...ag.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

--MFIETISETDTGFYVIREITITH-----TKQGNEvRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlfgggPVVVHDSSSVGRSGTFCIINIVI
  .. |  .| . |      ||           |.|  ..... .. | .   | .  . . ..  |.| ..     ||. | |. |||.||...|. .|
hrvyteycteieiggkskdkithrvlkvvvkatgqe.sklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmi

ERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYLESFDKY
  |.     ..  .   ||.     |  . |. .. ....|.| |   |
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1225-1320 6e-19 62.0 In-house 4-95 (95) alignment 
Range on Protein: 1225-1320
Range on HMM: 4-95/95.0
SISVSMFPDYVKRLHANTDHLFSEEYELITIKSPSlPHEASQQTCNIEKNRYGNINSFDETRVVLTKIpgiEGSDYINANYIDGYGSRDTYIACQG
 | ||.|  .|  .|.|.|. | .|.  |.. | . |. .    .|| |||. ||  .| ||||||       |||||| ..|||  .. |||.||
pihvsvfhshvlemhsnsdqefdnefksismtsga.pytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1554-1802 9.7e-18 58.8 In-house 34-279 (303) alignment 
Range on Protein: 1554-1802
Range on HMM: 34-279/303.0
AIPSQYISASLPVNRAKNRYPDILPYESYRVRLlmlpgvSGSDYINASYVDGYlRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSV
 .| .     .  |  |||. |..  .  .|.|      | | || |||..     .. |.|| ||| |  |||.|| | .|  ...|    |  |    
ylppsvsknqfvknmdknrfvdvicldhskvkl......sdssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggd

QYWPKDQ-LTQYGDMFIETISETDTGFYVIREITITHTKQGNEVRNIKQFHYTDWSENKTPPT-TGALMDMIVLVQKAHHLFG-GGPVVVHDSSSVGRSG
  .|..| . .. . .|         .     . .    .|.    ..  || .|  |. |   .  ..  |  .|     .  . | |    | .||.|
svfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgrag

TFCIINIVIERLKVE-GMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
||....     |. |   .|.   .  .|      | |  || . |  . |..
tfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1269-1503 3.6e-17 56.7 In-house 50-288 (302) alignment 
Range on Protein: 1269-1503
Range on HMM: 50-288/302.0
CNIEKNRYGNINSFDETRVVLTKIPgiegSDYINANYIDGYGSRDTYIACQGPLAETS---PDFWRMIWEQKTSCIVMLTNCVEKGRpKCHQYWPQTGS-
 |..||.  ...  |...| |.. |     .|.||  ..    . . |  | |  ...    .||||....|   .|.|    |  .   ....|..   
knlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

-TTFGELTVTI-----IDQQVlAYYTIRTFkiNNKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIRRV--NNSTHTGPLVVHCSAGVGRSGTFIAIQSM
 ...|.. | .      ....   |.|  .   .   .|  ..  . | |..  ||.. . .|  .  |  ...  . ..|.    |.|| |.|..    
ykeygkmfvNnrkVekaeeek.tryviEvl..PegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

MLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVG
.  .... .. . . |  .| .|  .|..  ||.... .|. .||  
veklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1313-1493 4.1e-17 57.0 In-house 4-196 (198) alignment 
Range on Protein: 1313-1493
Range on HMM: 4-196/198.0
DTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGST--TFGELTVTIIDQQVLAYYTIRTFKINNKD---DESFEVKQFHYTA
  |||.| || ||  |||.|.||  .  |||. .   .       ||| | |.   .| |.||     . . ||| .. . |.      . |. .. .|.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDFGVPDHPNpIISFI---RRVNN---STHTGPLVVHCSAGVGRSGTFIAIQSMMLMMET--EGKVDVFNFVLDMRHKRNYMVQTEAQYMFVH
| .   |.    .. |.   | | .     .  |..|||| | | .| |.|..  .   |      ||.|.    .|  |  .. .  .| |..
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1313-1493 4.2e-17 57.0 In-house 5-197 (199) alignment 
Range on Protein: 1313-1493
Range on HMM: 5-197/199.0
DTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQTGST--TFGELTVTIIDQQVLAYYTIRTFKINNKD---DESFEVKQFHYTA
  |||.| || ||  |||.|.||  .  |||. .   .       ||| | |.   .| |.||     . . ||| .. . |.      . |. .. .|.
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDFGVPDHPNpIISFI---RRVNN---STHTGPLVVHCSAGVGRSGTFIAIQSMMLMMET--EGKVDVFNFVLDMRHKRNYMVQTEAQYMFVH
| .   |.    .. |.   | | .     .  |..|||| | | .| |.|..  .   |      ||.|.    .|  |  .. .  .| |..
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1556-1714 1.9e-16 54.4 In-house 85-237 (244) alignment 
Range on Protein: 1556-1714
Range on HMM: 85-237/244.0
PSQYISASLPVNRAKNRYPDILPYESYRVRLLmlPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLcGLVEDGkDqsvQY
||    |  | |  |||    ||..  || |    |  |  |||||.|    |  ..|.|| ||..|  |||.|. |  |  .|.| | ||.  |   .|
psvmkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvl.gsveee.d...ey

WPKD-QLTQYGDMFIETISETDTgFYVIREITITHTKQGNEVR-NIKQFHYTDWSENKTPP
||    |  | .    |... |  |  |.   .    . ||    .  |  ..|  . | |
wpdseplewyeeditvtltdrde.fknikasnleiesdmneshqaltmfqisnwpsdgttp
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1595-1803 2.5e-16 54.7 In-house 46-260 (290) alignment 
Range on Protein: 1595-1803
Range on HMM: 46-260/290.0
SDYINASYVDgYLRCNQFIMTQGPLSNT-------VDDFWRMIWEHRVSAIVMLCGLVEDGKDQSV----QYWPKD--QLTQYGDMFIETISETDTGFYV
.||| |..|  .    ..|.|| |. ..       . .|| |. . .|  .||||   |  ...|     .| |.   .  ..... ..  |        
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

IREITITHTKQgnEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAhhlfgGGPVVVHDSSSVGRSGTFCIINIVIERLK-VEGMIDIFFTIHALRRK
.||..... ..  |   ..   . .|.. .....|  |...|  |..      . ||.||.   . || ..  |..    .   .| . .   ..|||..
tRelvvkfdde..eeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkq

HPGIVANYDQFKFCYQTIVEYLE
    . .. .. |    || .. 
ralaitsalelafvdagivllai
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1620-1802 2.9e-16 54.3 In-house 38-221 (255) alignment 
Range on Protein: 1620-1802
Range on HMM: 38-221/255.0
SNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWP--KDQLTQYGDMFIETISETDTGFYVIREITITHTKqGNEVRNIKQFHYTDWSENKTPPTTG
| ||| |...|   . . .|||| . |.|...  .|.|  ||.  .. |. . |   .       .||| | ..   . ...| ..|. | |...|  . 
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlge.kkkthtvkhysykGWieknaPelar

ALMDMIVLVQKAHhlfgggPVVVHDSSSVGRSGTFCIINIVIE----RLKV--EGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
 .. .. .|....      .|||| |. .||| .| ....|       |.    . .|    .. || | .. . .  |. |.  ......
eilnilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0048076 (Phosphotyrosine protein) phosphatases II 1681-1800 4.8e-16 54.2 In-house 24-141 (145) alignment 
Range on Protein: 1681-1800
Range on HMM: 24-141/145.0
VIREITITH-----TKQGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlfGGGPVVVHDSSSVGRSGTFCIINIVIErlkvEGmIDIFFTIH
 ...  ||.     . . ...|.. |..|..|  . .|. .  |.... ....|.    ||||.|| |  |||.||.... ....    .| .... ...
llkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealk..eggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleeale

ALRRKHPGIVANYDQFKFCYQTIVE
 .|...||.| | .|..|.|. . |
lvrsqrpgavpnpgqlrflyefele
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1692-1804 7.8e-16 52.4 In-house 84-196 (440) alignment 
Range on Protein: 1692-1804
Range on HMM: 84-196/440.0
QGNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHLFGGGPVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQF
.| | | .||.||  | ..  |  .| .. ||  |.....  | ||..|| |...||.|    .. ..   |    ||||  | ..| ..| .|   .|.
ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy

KFCYQTIVEYLES
 | .....| | .
afvheavlegllc
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1564-1802 8.3e-16 52.3 In-house 48-285 (302) alignment 
Range on Protein: 1564-1802
Range on HMM: 48-285/302.0
LPVNRAKNRYPDILPYESYRVRLLMLPgvsgSDYINASYVDGYLRCNQFIMTQGPLSNTV---DDFWRMIWEHRVSAIVMLCGLVEDGKdQSVQYWP--K
   | .||. .|.  ..| .|.| . |     .|.||| |.     .. |..| | ....   ..||||......  .|.| |  |  |    ...|   
fkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

DQLTQYGDMFIET--ISETDTGF--YVIrEItITHTKQGNEVRNIKqfHYTDWSENKTPPTTGALMDMIVLVqKAHHLFGGGPVVVHDSSSVGRSGTFCI
.. ..||.||. .  .....     ||| |. . .      . |..  . | | ..| |   ..|.  .. |  |..  .  ..|.     .|| |.|  
gdykeygkmfvNnrkVekaeeektryvi.Ev.lPegcsnsvlanvy..vltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagaflt

INIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
  ...|.|. .    |  .....| . | .| ...|. . | ... |.
lavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_eak_pd Subfamily eak 1573-1802 2.4e-15 50.8 In-house 57-305 (332) alignment 
Range on Protein: 1573-1802
Range on HMM: 57-305/332.0
YPDILPYESYRVRLLMlPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKDQ--LTQYGDMFIE
  .|.||. | |||          ||||| ..     ...|.|  .  . |  ||.|. | .  |||.|   || . ..| .|.|..     ..| . .|
vvkivpydrylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

TISETDTGFYVIREITIthtKQGNEVRNIKQFHYTDWSENKTPPTT------------GALmDMI--------VLVQKAHHLFGGGPVVVHDSSSVGRSG
. .    . .  | . .   ..|||  ... ...  |.| ..|               |.|  .|         ...| .|       ..  .    |.|
rkefvkrniletrllel...skGnethrvlhykvfGwtettlpkyedflalrkvmkevGvl.llivmksallsstlkkyihtppsfapiiqsarGsaraG

TFCIINIVIERL--KVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
.| .|...|. .  |.. .  .   |   . |    |    |  | |. ...||
vfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1393-1499 1.2e-14 48.9 In-house 210-343 (350) alignment 
Range on Protein: 1393-1499
Range on HMM: 210-343/350.0
KDDESFEVKQFHYTAWPDFGVPDHPNPIISFIR------------RVNNSTHTGPLVVHCSAGVGRSGTFIAIQSMML---MM----ETEGKVDV-----
   . ..| |...  |.| ..  .|. |.. .                .. .. |..||||||||| ||.... |..    ..    .   |.||     
aasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktr

---FNFVLDMRHKRNYMVQTEAQYMFVHDSLVEL
   .  |. .|..|  |||.  |..|....|  .
DlisiivnelrkqrismvqnldqfifiYeallfy
0048179 (Phosphotyrosine protein) phosphatases II 1682-1796 1.4e-14 49.5 In-house 33-139 (144) alignment 
Range on Protein: 1682-1796
Range on HMM: 33-139/144.0
IREITITHTKQgNEVRNIKQFHYTDWSENKTPPTTGALMDMIVLVQKAHHlfGGGPVVVHDSSSVGRSGTFCIINIVIerlkVEGmIDIFFTIHALRRKH
.  .| .. ..  . |.. |.....|  . .|. .  | ... ....|.    ||||.|| |  |||.||.... ...    ..| .... ... .|...
vinlteeyepe.fleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrr

PGIVANYDQFKFCYQ
||.| | .|..|...
pgavpnpgqlrfLle
subfamily_eak_pd Subfamily eak 1262-1415 6.9e-14 46.0 In-house 44-196 (332) alignment 
Range on Protein: 1262-1415
Range on HMM: 44-196/332.0
HEASQQTCNIEKNRYGnINSFDETRVVLTKIpGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKCHQYWPQ
 . .... ....| .. |  .|   | ||     .   ||||  ..       ||    .  .  . ||.|. |||. .||.| . ||..  |  .|.|.
isetarleavnrnvvk.ivpydrylvrltss.qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd

TG--STTFGELTVTIIDQQVLAYYTIRTFKINnKDDESFEVKQFHYTAWPDFGVPD
 .     || | |.  .    . .  | .... | .|. .|. ...  | .. .| 
ktreelkfGildverkefvkrniletrllels.kGnethrvlhykvfGwtettlpk
subfamily_CG42327_pd Subfamily CG42327 1429-1498 1.3e-13 45.3 In-house 243-313 (319) alignment 
Range on Protein: 1429-1498
Range on HMM: 243-313/319.0
NSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETE-GKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVE
.  . |||||||| ||||.|. ||    .  .|.    ||. . |  .|. |   |.|  || |..  | |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
fn3 Fibronectin type III domain 864-949 1.5e-13 43.9 Pfam-A 2-85 (85) alignment 
Range on Protein: 864-949
Range on HMM: 2-85/85.0
SPTIVSVFSTSNDSLSVSWSEIPpeETNGPIINYTIQFKINNNDN-QDMFQTVNTTQlQFTLTGLSGGTEYIIQVAGNTVIGHGPFS
.|. .|| .....||..|||. .  . .||| .|.....  .. .    |.. .||. ..|||||  |||| ..|.  .  | ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1307-1403 2.6e-13 44.1 In-house 230-323 (440) alignment 
Range on Protein: 1307-1403
Range on HMM: 230-323/440.0
DGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKgrpKCHQYWP-QTGSTTFGELTVTIIDQQVLAYYTIRTFKINNKDdESFEVKQF
.||  ....|| | ||  |  ||||.. . . | |.|| .  .|    |  ||| .| | ||| .||     . .    .||.... |. |  |..||
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyke.evheirqf
subfamily_hpo-7_pd Subfamily hpo-7 1619-1795 4.6e-13 43.7 In-house 43-220 (263) alignment 
Range on Protein: 1619-1795
Range on HMM: 43-220/263.0
LSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWP--KDQLTQYGDMFIETISETDtgFYVIREITITHTKQ-GNEVRNIKQFHYTDWSENKTPPT
| .|.| |...|   . . .||||   |.|...  .|.|  ||.  .. .. . |    .    ... . .. | .   .....|.. |. | |.. |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

TGALMDMIVLVQKAHhlfgggPVVVHDSSSVGRSGTFCIINIVIE----RLKV--EGMIDIFFTIHALRRKHPGIVANYDQFKFCY
.   . .. .... .      ..||| |. .|||  | ....|       |.    . .|    .. || . .. . .  |. |  
areilnilkvarnsk......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1577-1714 1.8e-12 41.7 In-house 3-128 (130) alignment 
Range on Protein: 1577-1714
Range on HMM: 3-128/130.0
LPYESYRVRllmlpgvsGSDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLcGLVEDGKdqsvQYWPKDQLT-QYGDMFIETISET
|..|  |..        | .|||||.|    | .....|| ||..|  |||.|. |  |  .|.| | ||.      .|||  .    | .  | |... 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl.gsveeed....eywpdsePlewyeediivtltdr

DtGFYVIREITITHTKQGNE-VRNIKQFHYTDWSENKTPP
| .|  |.   .   .. ||  . .  |. ..|  . | |
d.efknikasnleiesdlneshqaltmfqisnwpsdgttp
I-set Immunoglobulin I-set domain 376-447 1.9e-12 38.8 Pfam-A 3-74 (90) alignment 
Range on Protein: 376-447
Range on HMM: 3-74/90.0
ISQIESETILPVGDSVVLSCTVTGSPAPMIRWYRDGSIMND--GIATATEGliIQSNLTLANLQQNQTGVYQCV
..|. ...   .|.|| |.|||.|.| | ..|..||| ..    .    |.   .. ||. | .....| |.|.
ftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee..aeytLtIsnvevsDeGkYtck
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1617-1793 4.8e-12 40.0 In-house 98-279 (302) alignment 
Range on Protein: 1617-1793
Range on HMM: 98-279/302.0
GPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKDQSVQYWPKD--QLTQYGDMFIETIS-------ETDTGFYVIREITITHTKQGNEV-RNIKQFHYTD
 |  .|.. .| .| ...|. .| ||..|||.. .  .|. ..  .  ..|   ..|.|        ||   ...  . |. .|. ..| . .. .... 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WSENKTPPTTGALMDMIVLVQKAHHlfgggPVVVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKF
| .  .|  . . .|..   .   .      |.|| |  |||.||.  |   |.  . . . |.   .  .|.   | | . .|  .
wpdhGapkeaytaldilkfcesykk.....nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1547-1617 3.1e-11 37.3 In-house 28-95 (95) alignment 
Range on Protein: 1547-1617
Range on HMM: 28-95/95.0
KLNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLmlpGVSGSDYINASYVDGYLRCNQFIMTQG
...|| ..  . |   |   |  |||. .|.||.. || |        |||||| .|||| | | .| .||
efksismtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1267-1353 3.7e-11 37.1 In-house 31-116 (332) alignment 
Range on Protein: 1267-1353
Range on HMM: 31-116/332.0
QTCNIEKNRYGNINSFDETRVVLTKIPGieGSDYINANYIDGYGSRDTYIACQGPLAE-TSPDFWRMIWEQKTSCIVMLTNCVEKGRP
   |.. ||   .  || .|| |.   |    |. ||...|||  . .|| .| |. . |   ||||. |.| | |... .  || . 
flnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
Ig_2 Immunoglobulin domain 381-452 1.1e-10 33.4 Pfam-A 7-68 (80) alignment 
Range on Protein: 381-452
Range on HMM: 7-68/80.0
SETILPVGDSVVLSCTVTGSPAPMIRWYRDGSIMNDGiatategliiQSNLTLANLQQNQTGVYQCVFVSPG
. | .. |..|.| |...| |.| . ||.||.... .          |..| . |.. .. |.|.|.   ..
pptvvtegenvtLtCqapgnptpkvqwykdgeelsqs..........qnalfipnvsaedsGtYtCrasnse
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1272-1361 1.1e-10 35.3 In-house 50-155 (349) alignment 
Range on Protein: 1272-1361
Range on HMM: 50-155/349.0
EKNRYGNINSFDETRVVLTKIP--------------GIEGSDYINANYID--GYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKGRPKC
 |||| .|  .. .||.| | .              .    |||||||.    .     ||| | ||  |  ||...|  ..   .. |..  |..  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HQYWPQ
..|| .
diywqe
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1739-1802 1.2e-10 35.6 In-house 2-65 (69) alignment 
Range on Protein: 1739-1802
Range on HMM: 2-65/69.0
VVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
||| ||  ||.|||  | . . |.| | ..|||  .  .|.  | .| |  .. | . ..|| |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1739-1802 1.3e-10 35.4 In-house 1-64 (69) alignment 
Range on Protein: 1739-1802
Range on HMM: 1-64/69.0
VVHDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
||| ||  ||.|||  | . . |.| | ..|||  .  .|.  | .| | ... | ....|| |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1224-1312 2.7e-10 34.2 In-house 4-89 (440) alignment 
Range on Protein: 1224-1312
Range on HMM: 4-89/440.0
QSISVSMFPDYVKRlhANTDHLFSEEYELITIkSPSLPHEASQQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINANYIDGYGSR
. | |. | |||.         | .|. |.   . | | . .    |  |||| || ..| .||.| .. |.  |||||| ||.|  ||
rpiivadfadyvqn..nrrsrafedewsllps.glsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1567-1659 3.1e-10 33.9 In-house 48-156 (349) alignment 
Range on Protein: 1567-1659
Range on HMM: 48-156/349.0
NRAKNRYPDILPYESYRVRLLMLPGV--------------SGSDYINASYVDG--YLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEDGKD
  ||||| ||||||  ||.|   .                   ||||| |.    .   ...| || ||  |||||...|   .|  .. |    | . .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

QSVQYWPKD
.  .|| . 
kcdiywqel
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1295-1412 3.9e-10 34.1 In-house 10-125 (130) alignment 
Range on Protein: 1295-1412
Range on HMM: 10-125/130.0
IEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKgrpkcHQYWPQTGSTTFG--ELTVTIIDQQVLAYYTIRTFKINN
..| .||||...   |    |.  | |||.|| |||.|. |.    .|.|    |.      .|||..    .   ...||. |..   .     ..|..
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefknikasnleies

KDDESFE-VKQFHYTAWPDFG
.  || . .  |. . ||  |
dlneshqaltmfqisnwpsdg
subfamily_CG42327_pd Subfamily CG42327 1735-1802 5.2e-10 33.5 In-house 247-315 (319) alignment 
Range on Protein: 1735-1802
Range on HMM: 247-315/319.0
GGPVVVHDSSSVGRSGTFCIINIVIERLKVE-GMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
 ||.||| |  |||.|.    .| |..|.     .||  ... .||     | . .|..| |... || 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1604-1658 5.8e-10 33.1 In-house 230-281 (440) alignment 
Range on Protein: 1604-1658
Range on HMM: 230-281/440.0
DGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLCGLVEdgKDQSVqYWPK
.|| . | || || ||  || ||||.. ..|.|.|.||  | .  |  |. ||| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd..ktcsi.ywpv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1390-1501 1.1e-09 32.1 In-house 210-345 (349) alignment 
Range on Protein: 1390-1501
Range on HMM: 210-345/349.0
INNKDDESFEVKQFHYTAWPDFGVPDHPNPIISFIR------------RVNNSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMET----EGKVDVFNFVL
|. . .. .|. |. .  |.| ..   |  |.  .                .. .. .|.|||||| ||.|... ..... ..|       |... .   
illavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallk

D--------MRHKRNYMVQTEAQYMFVHDSLVELIK
|        .| .|  |||  ||.......|.. ..
DlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1434-1498 1.1e-09 32.6 In-house 229-293 (297) alignment 
Range on Protein: 1434-1498
Range on HMM: 229-293/297.0
GPLVVHCSAGVGRSGTFIAIQSMMLMMETEGKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVE
 .|.|||||||||||  .  . .. ..  .   ||  ..  .|..|  .|||  |. ...|  ..
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_PTPDC1_pd Subfamily PTPDC1 1403-1495 1.3e-09 32.7 In-house 85-171 (182) alignment 
Range on Protein: 1403-1495
Range on HMM: 85-171/182.0
FHYTAWPDFGVPDhPNPIISFIRRVNNSTHTGPLVVHCSAGVGRSGTFIAIqsmMLMMETegKVDVFNFVLDMRHKRNYMVQTEAQYMFVHDS
..  .|.|.||.   . |.  .. |. . . | . ||| || || |  ||    .|.  .  ...  . .  .|.||   .||  |  .|.. 
vynfgwkDygvas.leriLdivkvvafalqegkvavhChaGlGrtGvliac...ylvyak..rltaekaiklvrskrpksiqtreqvelvkef
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1566-1649 2.8e-09 30.9 In-house 33-115 (332) alignment 
Range on Protein: 1566-1649
Range on HMM: 33-115/332.0
VNRAKNRYPDILPYESYRVRLLmlPGVSGSDYINASYVDGYLRCNQFIMTQGPLSNTVD-DFWRMIWEHRVSAIVMLCGLVEDGK
 |   || | .  ..  || |   |     |. |||.|||| . . .|..| |. .  .  ||||. |.. | |...  . |  |
nnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1312-1413 5e-09 30.1 In-house 136-235 (244) alignment 
Range on Protein: 1312-1413
Range on HMM: 136-235/244.0
RDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLTNCVEKgrpkcHQYWPQTGSTTFGE--LTVTIIDQQVLAYYTIRTFKINNKDDESFE-VKQFHYTAW
   ||  | |||.|| |||.|. |..   .|.|    |.      .|||..    . |  .|||. |.. .       ..|.   .|| . .  |  . |
taeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnw

PDFGV
|  | 
psdgt
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1621-1802 5.1e-09 29.2 In-house 129-309 (346) alignment 
Range on Protein: 1621-1802
Range on HMM: 129-309/346.0
NTVDDFWRMIWEHRVSAIVMLCgLVEDGKDQSVQYWP-KDQLTQY-GDMFIETISETDTGfyVIREITITHTKQGNEVRNIKQFH-YTDWSENKTPPTTG
  |.||| ||.. ..  . ..    .  |. .   .  ..   || | |||.      .|    .| ||    .||    | | | .. |   . || | 
sfvedfwymiyqeqihlvylmv.pddklkntttslfndenggyqytgkmfinnrradvsg..dpkeytievlpegnsdsvicqvhhhapwkhlqqppktl

ALMDMIVLVQKAHHLFGGGPVVVhDSSSVGRSGTFCIINIVIERLKVEGMIDIFFTIHALRRKHPGIVANYDQFKFCYQTIVEYL
 .. ||      . .   |  ||      ||. .|      |..|      .|.  ....... || |  . |.   |  ...|.
piikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1266-1418 5.5e-09 29.2 In-house 23-159 (169) alignment 
Range on Protein: 1266-1418
Range on HMM: 23-159/169.0
QQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINAnyidgygsrdtyiacqgplaetspdfwRMIWEQKTSCIVMLTNCVEKGR--PKCHQYWPQtG
. |||  |||     .   ||| | ..    |||||||                           |||||  .| ||.| .. .|    |.  .|     
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlh.p

STTFGEL-----TVT-----IIDQQVLAYYTIRTFKINNKDDESFEVKQFHYTAWPDFGVPDHPN
.  .||       |         . | . . .     . .|| . ... .||..||. |||. | 
avilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1268-1345 6.9e-09 29.7 In-house 35-117 (347) alignment 
Range on Protein: 1268-1345
Range on HMM: 35-117/347.0
TCNIEKNRYGNINSFDETRVVLTKI-----PGIEGSDYINANYIDGYGSRDTYIACQGPLAETSPDFWRMIWEQKTSCIVMLT
  ...|||  . .  |.|||||.       .  .   |||| .|    ..  ||  | || .|  |||.|.   | . .| . 
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1266-1418 7.6e-09 28.6 In-house 22-158 (169) alignment 
Range on Protein: 1266-1418
Range on HMM: 22-158/169.0
QQTCNIEKNRYGNINSFDETRVVLTKIPGIEGSDYINAnyidgygsrdtyiacqgplaetspdfwRMIWEQKTSCIVMLTNCVEKGR--PKCHQYWPQtG
. |||  |||     .   ||| | ..    |||||||                           |||||  .| ||.| .. .|    |.  .|     
eltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlh.p

STTFGE-----LTVTIID-----QQVLAYYTIRTFKINNKDDESFEVKQFHYTAWPDFGVPDHPN
.  .||     | |           | . . .   . . .|| . ... .||..||. |||. | 
avilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1553-1605 8.2e-09 29.3 In-house 35-85 (440) alignment 
Range on Protein: 1553-1605
Range on HMM: 35-85/440.0
VAIPSQyiSASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINASYVDG
.. ||.   |||| |. |||| .|| |.  || |  . ||  ||||||||..|
lsqpsd..iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1267-1308 9.6e-09 29.2 In-house 36-76 (244) alignment 
Range on Protein: 1267-1308
Range on HMM: 36-76/244.0
QTCNIEKNRYGNINSFDETRVVLTKIpGIEGSDYINANYIDG
 ..|  |||| ||  ||||||.|.     |||||||||||.|
lsanatknryinilpfdetrvilsss.kkegsdyinanyiqg
ig Immunoglobulin domain 388-447 1e-08 26.4 Pfam-A 1-63 (64) alignment 
Range on Protein: 388-447
Range on HMM: 1-63/64.0
GDSVVLSCTV-TGSPAPMIRWYRDGSIMNDGIATATEG---LIIQsNLTLANLQQNQTGVYQCV
|.|| |.|.| .|.| . . ||..|. ....  | .      ...  ||. |....  |.| ||
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe.vLtinnvtkedsGtYtCv
0038934 (Phosphotyrosine protein) phosphatases II 1402-1453 1.8e-08 29.8 In-house 81-135 (194) alignment 
Range on Protein: 1402-1453
Range on HMM: 81-135/194.0
QFHYTAWPDFGVPDHPNPIISFIRRVNN---STHTGPLVVHCSAGVGRSGTFIAI
...   .||.|..   . . .|.. |.        |  .||| ||.||.||..| 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
0048567 (Phosphotyrosine protein) phosphatases II 1381-1457 2.1e-08 28.7 In-house 16-101 (157) alignment 
Range on Protein: 1381-1457
Range on HMM: 16-101/157.0
AYYTIRTFKINNKDDESFEVKQ--FHYTAWPDFGvPDHPNPIISFIRRVNN-----STHTGPLVVHCSAGV---GRSGTFIAIQSMM
 ... .  . .. .   | . .  .... . ||| | . . ...||...|.     . . ....|||.||    ||..|.|.   ..
yfallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlil
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1595-1662 3.3e-08 27.5 In-house 70-134 (347) alignment 
Range on Protein: 1595-1662
Range on HMM: 70-134/347.0
SDYINASYVDGYLRCNQFIMTQGPLSNTVDDFWRMIWEHRVSAIVMLcglVEDGKDQSVQYWPKDQLT
  |||||..      ...|.|| || .|| |||.|.   .|. .| .    |  ||.... . . .|.
etyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti...fepikdeaieefanatls
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1543-1670 3.4e-08 26.6 In-house 3-98 (169) alignment 
Range on Protein: 1543-1670
Range on HMM: 3-98/169.0
KQFEKLNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINAsyvdgylrcnqfimtqgplsntvddfwRMIWEHRVSAIVMLC
|....|. .  .|  . . | | .| .|||    |     ||.|  .    |||||||                           |||||   | ||.| 
kgynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlg

GlvedgKDQSVQYWPKDQLTQYGDMFIE
.      |.  ..||. .  |     | 
d.....tddknnfwpekedyqlhpavil
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1545-1712 4.2e-08 26.2 In-house 4-153 (169) alignment 
Range on Protein: 1545-1712
Range on HMM: 4-153/169.0
FEKLNSIDVAIPSQYISASLPVNRAKNRYPDILPYESYRVRLLMLPGVSGSDYINAsyvdgylrcnqfimtqgplsntvddfwRMIWEHRVSAIVMLCGl
...|. .  .|  . . | | .| .|||    |     ||.|  .    |||||||                           |||||   | ||.| . 
ynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGd.

vedgKDQSVQYWPKDQLTQYGDMFI-----------ET--ISETDTGFYVIREITITHTKQGNEVRN-IKQFHYTDWSENKT
     |.  ..||. .  |     |            |  .    .|   . |...   .  ..| . .. .||. | .|  
....tddknnfwpekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngv
Ig_3 Immunoglobulin domain 377-447 4.6e-08 25.2 Pfam-A 6-72 (75) alignment 
Range on Protein: 377-447
Range on HMM: 6-72/75.0
SQIESETILPVGdsVVLSCTVTGSP-APMIRWYrdgsIMNDG-IATATEGLIIQSNLTLANLQQNQTGVYQCV
..... ..   .  | |.|...|.| .| |.||    | ... . .     ...| ||. . . ...|.|.||
vspsptvtsggn..vtLtCsaeggpppptisWy....ietppelqgsegssssestLtissvtsedsGtYtCv
subfamily_eak_pd Subfamily eak 1420-1505 1.1e-07 25.6 In-house 223-310 (332) alignment 
Range on Protein: 1420-1505
Range on HMM: 223-310/332.0
IISFIRRVNNSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMMETEGK--VDVFNFVLDMRHKRNYMVQTEAQYMFVHDSLVELIKVGNS
. |....   .  .   .. .. |  |.|.|. |. .. ...   |    | ...| ...||.. | .. |. |... ... ..  |.
lsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn
I-set Immunoglobulin I-set domain 577-660 1.9e-07 22.7 Pfam-A 8-83 (90) alignment 
Range on Protein: 577-660
Range on HMM: 8-83/90.0
PPIIVLRGDTVSFSCLASSIPVPNITWFRNDSSGPVslfddtesvVSIIST---StdgltTNSTLTI---TLESDGEYFCFASNDFFNDT
 .. |  |..|...| ..  | |...|....|.             . ..    .      ..||||   . .  |.| | |.| . ...
kdvevseGesvelectveGepepsvsWakdgselks.........sqrvkvtvee.....aeytLtIsnvevsDeGkYtckatnsagkae
Ig_3 Immunoglobulin domain 578-654 3e-07 22.6 Pfam-A 3-75 (75) alignment 
Range on Protein: 578-654
Range on HMM: 3-75/75.0
PIIVLRGDT------VSFSCLASSIP-VPNITWFrndssgpvslfddtESVVSIISTSTDGLTTNSTLTIT---LESDGEYFCFASN
 |.| .. |      |...| | . |  |.|.|               ..  .....| .  ...|||||.    | .| | | |||
visvspsptvtsggnvtLtCsaeggpppptisWy..............ietppelqgsegssssestLtissvtsedsGtYtCvasN
Ig_2 Immunoglobulin domain 577-664 5.1e-07 21.6 Pfam-A 7-76 (80) alignment 
Range on Protein: 577-664
Range on HMM: 7-76/80.0
PPIIVLRGDTVSFSCLASSIPVPNITWFRNdssgpvslfddtesvVSIISTSTDGLTTNStltITLESDGEYFCFASNDFFNDTSEPA
||  |  |..| . | |.. | |...| ..                ...|.|...| ...   ...|  | |.| |||.    .|.. 
pptvvtegenvtLtCqapgnptpkvqwykd...............geelsqsqnalfipn...vsaedsGtYtCrasnsegskqsnsv
subfamily_PTEN_pd Subfamily PTEN 1378-1492 5.2e-07 24.8 In-house 52-172 (184) alignment 
Range on Protein: 1378-1492
Range on HMM: 52-172/184.0
QVLAYYTIRTFKINNK-DDESFEVKQFHYTaWPDFGVPDHPNPIISFIRRVNNS-------THTGPLVVHCSAGVGRSGTFIAIQsMMLMMETEGKVDVF
..|  .    .|| |   ..... |.|.    . ... ||  | ....... ..        ..   |||| || ||.|. |.   .. .. .| . .. 
kflekkhkdhykiynlrserkydskkfdgr.vavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivay.llkslllekaeeal

NFVLDMRHKRNYMVQTEAQYMFV
..   .| | .  |.  .|  .|
elfaeaRtknkkgvtiPsqrRYv
V-set Immunoglobulin V-set domain 376-458 5.5e-07 20.4 Pfam-A 4-102 (114) alignment 
Range on Protein: 376-458
Range on HMM: 4-102/114.0
ISQIESETILPVGDSVVLSCTVT-GSPAPMIRWYRDGS------IM----------NDGIATATEGLIIQSN-----LTLANLQQNQTGVYQCVFVSPgv
.|| ...  . .|.|| |.|...  .   .|.||....      |.            .    .. |  ...     ||. ||... .|.|.|   ..  
vsqsprpvtvaeGgsvtLpCfysssensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsds..

ggvaY
    .
....n
PTEN_1 1396-1452 8.1e-07 24.0 In-house 88-149 (196) alignment 
Range on Protein: 1396-1452
Range on HMM: 88-149/196.0
ESFEVKQFH--YTAWPDFGVPDhPNPIISFIRRVNNST----HTGPLVVHCSAGVGRSGTFIA
|.|. ...      ..|.|.|.  . .. ..... ..     . .  .||| ||.||||| .|
eeffksgveylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
C2-set_2 CD80-like C2-set immunoglobulin domain 679-751 2e-06 17.8 Pfam-A 8-82 (89) alignment 
Range on Protein: 679-751
Range on HMM: 8-82/89.0
SAPPVViNSSIIINC-TSEGFPLPAISWLINETNLTGVDEFTVNTEMMSANRSVSTLSGNINN--NNTRLVCVASN
|  ..  |   . .| ...|.| | |.|. .. .|... ...   |      ..|||. .     ... |.|..|.
sllege.neevvatCvsaggkPapritWyldgkeleaietsseqdeesglvtvtstlkltpsredhgksltCqvsy
PTPc_motif_SM00404 1414-1479 2.7e-06 22.3 In-house 63-121 (140) alignment 
Range on Protein: 1414-1479
Range on HMM: 63-121/140.0
PDHPNPIISFIRRVnnSTHTGPLVVHCSAGVGRSGTFIAIQSMMLMmeTEGKVDVFNFVldmRHKR
 .. . ...||...   .  |  .||| ||| ||.|.|.   |. .       ....||   ...|
skyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryr..qlslaeayefv...kerR
I-set Immunoglobulin I-set domain 198-271 6.2e-06 17.9 Pfam-A 4-75 (90) alignment 
Range on Protein: 198-271
Range on HMM: 4-75/90.0
IIQPVDVHVPVNGTAAFSCSISPDsALINITWYSSEGMVASEDVINDFNDPGLSVLVINNVTESEGGvAYYCVA
 ... || | .. .. ..|... .   ....|.. .  ..|.. ..  .. . . |.|.||..|. |  | |.|
tqklkdvevseGesvelectveGe.pepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeG.kYtcka
DSPc Dual specificity phosphatase, catalytic domain 1408-1478 6.2e-06 21.1 Pfam-A 50-113 (133) alignment 
Range on Protein: 1408-1478
Range on HMM: 50-113/133.0
WPDFGVPDHPNPIISFIRRVnnSTHTGPLVVHCSAGVGRSGTFIAIqsmMLMMETEGKVD-VFNFVldmRHK
  .  . .. . ...||...   .  .  .||| ||. ||.|.|.     ||.. . ...  ..||   . .
etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliia...YlmktknlslneAyefv...ker
DSPc Dual specificity phosphatase, catalytic domain 1408-1478 6.2e-06 21.1 In-house 50-113 (133) alignment 
Range on Protein: 1408-1478
Range on HMM: 50-113/133.0
WPDFGVPDHPNPIISFIRRVnnSTHTGPLVVHCSAGVGRSGTFIAIqsmMLMMETEGKVD-VFNFVldmRHK
  .  . .. . ...||...   .  .  .||| ||. ||.|.|.     ||.. . ...  ..||   . .
etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliia...YlmktknlslneAyefv...ker
Ig_3 Immunoglobulin domain 210-271 7.2e-06 18.1 Pfam-A 16-73 (75) alignment 
Range on Protein: 210-271
Range on HMM: 16-73/75.0
GTAAFSCSISPDSALINITWYsseGMVASEDVINDFNDPGLSVLVINNVTESEGGVaYYCVA
|.  ..||.   ..  .|.||       .|.  .. .... |.|.| .||..  |. | |||
gnvtLtCsaeggpppptisWy...ietppelqgsegssssestLtissvtsedsGt.YtCva
Ig_3 Immunoglobulin domain 672-751 7.6e-06 18.1 Pfam-A 2-75 (75) alignment 
Range on Protein: 672-751
Range on HMM: 2-75/75.0
PVIITNPSAPPVVINSsIIINCTSEGFP-LPAISWL------INETNLTGVDEFTVNTEmmsanrSVStlsgnINNNNTrLVCVASN
|||...||  ...  . . ..|..||.|  | |||.      .. .. ..  | |.. .      ||.      ... |   |||||
Pvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtis......svt.....sedsGt.YtCvasN