Gene PTPRD-79 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP138_AA protein Get Run
AqueP138_AA_2375-2636 phosphatase_domain Get Run
AqueP138_AA_2647-2931 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 2377-2687 6.5e-126 416.2 In-house 28-335 (564) alignment 
Range on Protein: 2377-2687
Range on HMM: 28-335/564.0
EFGKIDINrssPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVED-SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTN
|. ||. .   .. ..... .|.|| .||||||  ||||||.|..||  .  |||||.||.||......|||||||..|| |||||||...| |.||||.
eykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltk

LQEKMRVKCTQYWPDTvGrSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHkYTDKRPMIIHC
|.|| .||| .|||.. | .|..| . ||. ...  |||.||.|........ .| ..|||.||||| ||| ..|.|...|..||...  .|. |...||
leEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhC

SAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAELE-IEDDEGETGYSHEFSRLQ-
|||||||||||.||. ..|. .|. .. ||.|...|..||.||||| |..|||.|..| |. |.|.. .|.|.... .|. .|.|.. ||...|| ||. 
SaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLat

SERAHFDDFYSARN
... . ..|..| .
akeieleefavatk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2376-2660 1e-105 348.3 In-house 24-305 (318) alignment 
Range on Protein: 2376-2660
Range on HMM: 24-305/318.0
AEFGKIDinRSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSP-HDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLT
.|. ...  ||. ...    |.|.|| .||||||  |||.||||...|...  ||||||.| ||.|....||.|.|||.|| |||||||. .| ..||||
eeyerls..rseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmlt

NLQEKMRVKCTQYWPDTvgRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKRPMIIH
...|. ..|. .|||.    |. .| . |.  .... .|| .|||... ..|. .| ..|.||||||| ||| ... |.... .|.. .. ....|...|
qeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

CSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAELEIEDDE
|||||||||.||..|. ..|. .|  .. .|.|.|.||.|| ||||| |..||.|.|.| |..|.|..  ..| .|. ||. .| |
CsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpe
subfamily_PTPRD_pd Subfamily PTPRD 2684-2939 1.8e-102 338.8 In-house 42-290 (564) alignment 
Range on Protein: 2684-2939
Range on HMM: 42-290/564.0
SARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYK
.|...||| |||..| ..|||.||.|.|..|. |||||||||||||.... |||.|.|. .|..|||.|. ||..|.|||| ..|||.. |  ..||| |
aankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgk.vkchkYWPek

rGeELAFGSASVTLQLTNHQEDYIHRQLRVtytPRDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQqQTGNKPILVHCSAGIGRTGAFCAL
 | .  .|.  |||. ... .||. |....    . .  |.| |..| ||||| .|.| .. ...|||..|.. . .....||.||||||.||||.|...
.g.tetygeltVtleeeeeladyeirtfkl...kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivi

SIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNSYANF
.. .||.| |. |.||..||.||.|| .|||. .||.||..|||.. .. |   . 
damlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteves
0050432 (Phosphotyrosine protein) phosphatases II 2382-2641 2.2e-98 324.7 In-house 50-305 (308) alignment 
Range on Protein: 2382-2641
Range on HMM: 50-305/308.0
DINRSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLtpveDSPHDYINANFIHGY--NRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEK
....  |... .|.| | || .||| .| .||||||||    |...|||||....||  .....|||||||||.|..|||||||.......||||.|.|.
ellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklven

MRVKCTQYWPDTVG-RSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHkytDKRPMIIHCSAG
 |.|| ||||...|  |...|...||... ....||..|..|..  ... .| ...||||.|||.||| .|..|..|.. ||...   .. |...|||||
grekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaG

VGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTD
||||||||..|  ... ..|....... |...|| |..||||. |..|...||.|.|.. .|.
vGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2642-2941 8.3e-98 322.3 In-house 2-291 (318) alignment 
Range on Protein: 2642-2941
Range on HMM: 2-291/318.0
IGIEQLEARMAELEIeddEGETGYSHEFSRLQSERAHFDDFYSaRNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAP
| .|.|| ....|.    .||. .|.|. ||. .....  . |  ...|| |||  | |.||| ||||... || |||||||..||||..|. |||||||
isvedleshvrrlre...sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaP

KDNTLNDFWKMICEQQVSVIVMLANTEEKEQFVMsAQYWPYKRgeELAFGSASVTLQLTNHQEDYIHRQLRVTYtprDTPPETRVVHHFSFTSWPRSGAP
  .|..|||.|. ||. .|||||...||. .  . ..||| |     ..|.  |.|. . . .||. |...||    .   |.|.|. . .|||| .| |
lpetieDfWrmvWeqnsavivmltqeeergkakv.hryWPskg..srsygklvvelkeevelsdyvlrefkvtr...teeeesrqvrqyhytsWpdegvp

SNGSGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNSYANFNS
..|....||. ||.| ||..|..||.||||||.|||| |.|..| .||.| | .|.....||.||.||  |||  |||.||| ..|.. .| ..... . 
esgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2377-2669 6.9e-97 319.3 In-house 28-318 (319) alignment 
Range on Protein: 2377-2669
Range on HMM: 28-318/319.0
EFGKIDINRSSpnpSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSP-HDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTN
|| ....  .    ..| . .. || .||| ||  ||..||.|.......  |||||.|| ||.. ..|||||.|| .|| |||||||..|| .|||||.
efkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltk

LQEKMRVKCTQYWPDTvgRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKT-TRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKRPMIIH
|.||..||. .|||..    |..| . ||  .    .|| ||....... ..  ||..|.|.||.||| .||.. | |..... .|. .. |...|...|
lveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvh

CSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAELEIE-DDEGETGYSHEF
||||||||||||..|  ..|  .|  |. ...|...|  || |||...|. ||..||.|....|.|.| ...|. |. .|.    | |||| ..||
CsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetgleref
subfamily_PTPRB_pd Subfamily PTPRB 2390-2639 2e-96 317.5 In-house 41-289 (293) alignment 
Range on Protein: 2390-2639
Range on HMM: 41-289/293.0
PSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDS-PHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYW
 .|..  ...|. .||| ||  ||||||||....|.   ||||||.|.|||  .||||||||||.|. |||||||. .| ..||||.| || .||| .||
qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYW

PDTVgRSERFGPISVTFIKSTSHADYCIREFEIQTqdEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHH-KYTDKRPMIIHCSAGVGRTGTFIT
|..  ..  .| |.||......  |. |||..|.   ||..|...|.|.|||||.||| ....|..|..|||... | ..|||...|||||||||||||.
Pade.epvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfia

IDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGK
.|  .|. ..|  .. . .| ..||.||..||||.|..|||......|....
ldrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
0051299 (Phosphotyrosine protein) phosphatases II 2383-2634 2.7e-95 314.4 In-house 32-285 (288) alignment 
Range on Protein: 2383-2634
Range on HMM: 32-285/288.0
INRSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVED-SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMR
. .  |.... ..| | |. .||| .| .||||||||..... ...|||||..|.|||....|||||||||.|..|||||||.......||||.|.|. |
llsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgr

VKCTQYWPDtvGRSERFGPISVTFIKSTSHADYCIREFEIQTQ----DEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKyTDKRPMIIHCSA
.|| ||||.  | |. .|.|.||... ....||..|..|..       ....| ...||||.|||.||| .|..|..|.. ||....  .. |...||||
ekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsa

GVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEI
|||||||||..|  ... ..|........|...|| |..||||. |..|...||.| 
GvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0036941 (Phosphotyrosine protein) phosphatases II 2384-2644 3.9e-95 313.8 In-house 23-286 (297) alignment 
Range on Protein: 2384-2644
Range on HMM: 23-286/297.0
NRSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLtpvEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVK
 .  ...| .| |.| |. .||| .| .|||.||||   .|...|||||... ||.....|||||||||.|..|||||||.. ....||||.| |. |.|
lpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrek

CTQYWPDTVGRSERFGPISVTFIKSTS--HADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYT-DKRPMIIHCSAGVG
| ||||...| |  .|...||... ..  ..||..|..|..  ... .| ...||||.|||.||| .|..|..||. ||...|.. .. |...|||||||
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvg

RTGTFITIDSEMQRAD---QERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGI
|.||||..|  .|. .    |........|...|| |...|||. |..|...|| | |....|.. .
RsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepl
0046845 (Phosphotyrosine protein) phosphatases II 2376-2641 8.9e-95 312.6 In-house 4-280 (284) alignment 
Range on Protein: 2376-2641
Range on HMM: 4-280/284.0
AEFGKIDINRSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVED--SPHDYINANFIHGY-----NRDNEFIATQGPLPDTIGDFWRMVWDYESP
.|| ..  .  ..  |..|.| | |. .||| .| .||||||||.....  . .|||||....||     .. ..|||||||||.|..|||||||.....
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

TVVMLTNLQEKMRVKCTQYWPDTvGRSERFGPISVTFIKSTSHADYCIREFEIQTQD-EKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKY-T
..||||.| |. |.|| ||||.. | . ..|...||... . . ||..|..|..  . .. .| ...||||||||.||| .|..|..|...||....   
vIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

DKRPMIIHCSAGVGRTGTFITIDSEMQRADQER---ELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTD
.. |...|||||||||||||..|  ... ..|.   ...... |...|| |..||||..|..|...||.| |....| 
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2390-2654 1.4e-93 308.4 In-house 36-302 (305) alignment 
Range on Protein: 2390-2654
Range on HMM: 36-302/305.0
PSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSP-HDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYW
 |.||  . .|| .||...|. .|..|..||. |. . .|||||....||.| ...|..||||..|. ||||.....   |.||||.|.|  . || |||
esidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYW

PDTVGRSERFGPISVTFIKSTSHADYCIREFEIQT-QDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKRPMIIHCSAGVGRTGTFIT
|........||..||.   ... .|| .|...| . ...| .|.. |.. |.||| |||. .| |...|. |....|   . |...||||||||||.||.
pesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfia

IDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAEL
.|  ..|. .| ... .. ..|.|..|  |||| .|.||.|||| | ...|.|.| .. |.||.  |
vdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl
0051299 (Phosphotyrosine protein) phosphatases II 2639-2930 7.6e-93 306.4 In-house 2-286 (288) alignment 
Range on Protein: 2639-2930
Range on HMM: 2-286/288.0
KTDIGIEQLEARMAELEiedDEGETGYSHEFSRLQSERAHfDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAA
.|.| .|.|. .. .|      | ||.  || .|.|  ..  ....|.  .|..|||  . |||||.||||. ..|. ||||||||.||||. |. .||.
dteisveellklvlkll...angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIat

QAPKDNTLNDFWKMICEQQVSVIVMLANTEEkEQFVMSAQYWPYkrGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTP-RDTPPETRVVHHFSFTSWPR
|.|..||..|||.|. ||.|.||||| ...|  . . .|||||   |. | .|  .|||  . ...||..|.|.||..   | . |.| |.|| .|.|| 
qgPlpntvedFWrmvweqnvrvIvmltklve.lgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpd

SGAPSNGSGMIDLIDQVQKRQQqTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
 |.|.. . ..|.. .|.| ..  |..|..||||||.||||.|.|| ...|... |. |.....||.||.|| .|||...||.|.|.|.|.|.
hgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 2382-2655 2.4e-92 304.9 In-house 26-296 (317) alignment 
Range on Protein: 2382-2655
Range on HMM: 26-296/317.0
DINRSSPNpSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVED-SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKM
|. . ... . .| . | || .||| .| .||||||||.|..   ..|||||....|.|. ..|||||||||.|..|||||||.. . ..||||.| |. 
dllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelg

RVKCTQYWPDtvGRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKyTDKRPMIIHCSAGVG
|.|| ||||.  | .  .|...||... . .|....|..|..  .....| ...||||.|||.||| .|..|..|.. ||.. .  .. |...|||||||
rekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvg

RTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAELE
||||||...  ... ..|....... |...|| |...|||..|..|..||| |.|... |.. . .|  .. .| 
RtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkll
0047943 (Phosphotyrosine protein) phosphatases II 2383-2634 2.6e-92 304.4 In-house 21-271 (273) alignment 
Range on Protein: 2383-2634
Range on HMM: 21-271/273.0
INRSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLtpvEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRV
. .  |. .  |.| | || .||| .| .||||||||   .|...|||||... |||. ..|||||||||.|..|||||||.. ....||||.|.|. |.
llslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgre

KCTQYWPDTVGR-SERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYT-DKRPMIIHCSAGVG
|| ||||...|  |...|...||... ....||..|..|..  . . .| ...||||.|||.||| ....|..||. ||...... .. |...|||||||
kcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvg

RTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEI
||||||..|  ...   |....... |...|. | .||||. |..|...||.| 
RtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2658-2935 3.3e-92 303.9 In-house 18-288 (319) alignment 
Range on Protein: 2658-2935
Range on HMM: 18-288/319.0
DDEGETGYSHEFSRLQSERAHfdDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQ
.. |||.  .||  |.   .   .|.|| .. ||.||| .| |.||. ||.|....|  |||||||||||||. .. .||.|||..||..|||.|. |..
astgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeee

VSVIVMLANTEEKEQfVMSAQYWPYKRGEElaFGSASVTLQLTNHQEDYIHRQLRVtyTPRDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKR
.|..|||..  || . |   .|||..  ||  .|   |||.  ...|||| |.| .   .. .  ||| | || .|.||  . | .. ...||. ...| 
ssivvmltklveklk.vklkkywpeenfee..yGrlivtleeeeeledyiirklkl..nkkssevetRevkhfqyteWpdhdvPekatslldllkrirks

QQQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNS
...| ..|| ||||||.||||.|..|....|||| | .......|..|||||  |||. .|| ||| |.|...|. ..
rektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
DSPc_SM00195 2385-2635 6.3e-92 303.0 In-house 11-262 (263) alignment 
Range on Protein: 2385-2635
Range on HMM: 11-262/263.0
RSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVED-SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVK
.| .. ...    . || .||| || .|||.||||.. |. ...||||||.| |.|.....||||||||.|. |||||||. .....||||. .|. . |
estspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkek

CTQYWPDTVGRSERFGPISVTFIKSTSHA-DYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTdKRPMIIHCSAGVGRT
|..|||.. |..|.|| |||.... ...  .. .|..|.. .....||...|..|..||| ||| ...........|. ... . . |...|||||||||
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRt

GTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEIL
|||.|||. ... ..| ...  . |...|..| .||||..|. ||..|..| .
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2385-2635 6.3e-92 303.0 In-house 11-262 (263) alignment 
Range on Protein: 2385-2635
Range on HMM: 11-262/263.0
RSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVED-SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVK
.| .. ...    . || .||| || .|||.||||.. |. ...||||||.| |.|.....||||||||.|. |||||||. .....||||. .|. . |
estspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkek

CTQYWPDTVGRSERFGPISVTFIKSTSHA-DYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTdKRPMIIHCSAGVGRT
|..|||.. |..|.|| |||.... ...  .. .|..|.. .....||...|..|..||| ||| ...........|. ... . . |...|||||||||
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRt

GTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEIL
|||.|||. ... ..| ...  . |...|..| .||||..|. ||..|..| .
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0050432 (Phosphotyrosine protein) phosphatases II 2659-2936 1.1e-90 299.4 In-house 38-305 (308) alignment 
Range on Protein: 2659-2936
Range on HMM: 38-305/308.0
DEGETGYSHEFSRLQSERAhFDDFYSARNDANKDKNRLHNALPYDHNRVKLtkipgEIGSDYINASFIDGY--KAKNCYIAAQAPKDNTLNDFWKMICEQ
  . .... || .|.|      ....|.  .||||||  . |||||.||||     . ||||||||..|||  | .. .||.|.|..||..|||.|. ||
aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweq

QVSVIVMLANTEEkEQFVMSAQYWPYKRG-EELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDtppETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQ
.|.||||| ...|  . .  ||||| . | . | .|  .|||  . ...||..|.|..|..  .   |.|.|.|| .|.||  |.|.. . ..|....|.
nvrvIvmLtklve.ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg...esrtvthfhytnWpdhgvPpspeilldflelvr

KRQqqtGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNSY
|..   ...||.||||||.||||.|.|| ...|... |. |.....||.||.||..|||...||.|.|||.|.|....  .
ksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
subfamily_PTPRG_pd Subfamily PTPRG 2377-2649 1.2e-90 299.4 In-house 24-301 (563) alignment 
Range on Protein: 2377-2649
Range on HMM: 24-301/563.0
EFGKIDINRSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSP--HDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLT
|| ..  .  | .  ..   .| || .||| ||  ||.|||||.|. .    .||||||.|.||.. ..||||||||.||. |||||.|. .. ..||.|
efealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmit

NLQEKMRVKCTQYWPDtvGRSERFGPISVTFIKSTSHADYCIREFEIQT------QDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRhHKYTDK
||.|..| || .|||     ||..| ..|| |..  .| | .|.. |.       .. .| . ..|.|||.||| ||| |..| ..|..   .  . .. 
nlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssa.ankaea

RPMIIHCSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEA
 |...|||||||||||.| .|. ...  ||   | ..|....| .||..|||| |..|.||||.|......|..  ||.|.
GPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2638-2937 5.3e-90 296.7 In-house 1-297 (298) alignment 
Range on Protein: 2638-2937
Range on HMM: 1-297/298.0
GKTDIGIEQLEARMAELE-IEDDEGETGYSHEFSRLQSERAHFDD--FYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNC
|.|.|  |.|.| . .|. .. ... |||..|| ||.|   . ..     ||...||.|||  . ...|. || |.|. ..  ||||||||...|| .| 
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYKRGEElaFGSASVTLQLTNHQEDYIHRQLRVTYTPRDtppETRVVHHFSFTS
.||.|||  .|..|||.|..|.....|||| |.||... .   .||| .. |.  .|. .|.|. .... |.| |.| |. . ..   ..| |....|||
fiatqaPltetvedFWrmvteedigtiVmltnleeldk.tkyhkywPdegket..ygeitvsllskeefadlivrklkvskkkee...kerevrqlhfts

WPRSGAPSNGSGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLN
||  |.|.| . ..||...|.. |||.||||..|.||||.||.|.|.|..  .|||| |. | ....|| ||..|...||  .|||||| |.|.. .| |
WpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn

SYA
 ..
dei
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2378-2642 6e-90 296.5 In-house 33-297 (298) alignment 
Range on Protein: 2378-2642
Range on HMM: 33-297/298.0
FGKIDINRS-SPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTP-VEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTN
| ...   |  .. . .|  .| || .||||.|  .|.||| |.   .|   ||||| |.|.|.. | |||||.||. |. ||||||..... |.|||||
fqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltn

LQEKMRVKCTQYWPDTvgRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKRPMIIHC
|.|. ..|...||||.  ..|..| |.|.  .. ..||. .|..... ..|...|...|.|.||||| |||.. | ...... ||.... . ..|.|..|
leeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqC

SAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDI
||||||.|||| ||| ..|. .|. .  .| |. .|..| ..||||.|.|||..|  | |......|
saGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0046845 (Phosphotyrosine protein) phosphatases II 2667-2937 1.1e-89 295.8 In-house 4-281 (284) alignment 
Range on Protein: 2667-2937
Range on HMM: 4-281/284.0
HEFSRLQSERAHFD-DFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGE-IGSDYINASFIDGY-----KAKNCYIAAQAPKDNTLNDFWKMICEQQVS
 || .|.|   ..  ... |.  .|..|||  . |||||.||||. ..|.  .|||||||..|||     . |. .||.|.|..||..|||.|. ||.|.
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

VIVMLANTEEkEQFVMSAQYWPYKrGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTprDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQ
||||| ...|  . .. ||||| . || | .|  .|||  .....||..| |..|..  ... |.| |.|| .||||  |.|.. . .......|.. ..
vIVmltelve.ngrekcaqYwple.gevltygdftvtllseevkddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedlleflrlvrelle

Q-TGNKPILVHCSAGIGRTGAFCALSIAIERVKVEH---IVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNSYA
.  |..||.||||||.||||.|.|| ...|... |.    |.....||.||.|| .|||.|.||.|.|.|.|.|. ... ..
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0039614 (Phosphotyrosine protein) phosphatases II 2383-2640 1.9e-89 295.3 In-house 41-294 (297) alignment 
Range on Protein: 2383-2640
Range on HMM: 41-294/297.0
INRSSPNpsVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVED--SPHDYINANFIHGYNR-DNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEK
. .  |.    ..| | || .||| .| .||||||||.|...   ..|||||... ||.. ...|||||||||.|..|||||||.. ....||||.| |.
llslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvel

MRvKCTQYWPDTVGrseRFGPISVTFIKSTSHADYCIREFEIQTqdEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYT-DKRPMIIHCSAG
 | || ||||...|   ..|...||..| . ...|..|..|..   .. .| ...|.||.|||.||| ... |..|.. ||...... ...|...|||||
gr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaG

VGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKT
||||||||...  ... . |....... |...|| |...|||. |..|..|||.| |....|
vgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_PTPRA_pd Subfamily PTPRA 2665-2930 3.2e-89 294.0 In-house 34-295 (330) alignment 
Range on Protein: 2665-2930
Range on HMM: 34-295/330.0
YSHEFSRLQSERAHfDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVML
.  ||  | . . .   .  | .. ||.|||. | ||||..|| |... |.  ||||||||||||| |. .|||| ||..|..|||.|| ||. . ||||
freefnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativml

ANTEEKEQFvMSAQYWPYKrGeELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDT-PPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTGN
.. .|...    ||||| . |  ...|   |... ..  .||  |.. |.  |  |   ..|.|. | |||||  | |... ||..|. .|.| .||...
telkerkee.kcaqywPde.G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag

kPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
 || ||||||.||||.|..|.  .|||| |..|.....||.||.||..||| . ||.|||...|.| 
.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
0045450 (Phosphotyrosine protein) phosphatases II 2386-2635 2.5e-88 292.0 In-house 41-304 (307) alignment 
Range on Protein: 2386-2635
Range on HMM: 41-304/307.0
SSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVED--SPHDYINANFI--------HGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTN
  .. . .. | | || .||| .| .|||.||||.....  ...|||||...        .||.....|||||||||.|. |||||.|.. . ..||||.
vfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmlte

LQEKMRVKCTQYWPDTvGRSERFGPISVTFIKSTSHADYCIREFEIQTQ-DEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYT-DKRPMII
| |. |.|| |||||. | .  .|.. ||... . ...|..| .|..    .. .| ...||||.|||.||| .. .|..||. ||.... . .. |...
lvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlV

HCSAGVGRTGTFITIDSEMQRADQERE---LNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEIL
|||||||||||||...  ... ..| .   ..... |...|| | ..||.. |..|...|| | |
HCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0040438 (Phosphotyrosine protein) phosphatases II 2663-2935 5.2e-88 290.6 In-house 18-281 (317) alignment 
Range on Protein: 2663-2935
Range on HMM: 18-281/317.0
TGYSHEFSRLQSERAHfdDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIV
|. . || .|.|   .  ..  |.  .||||||  . |||||.||||. ..|  .|||||||..||.. |. .||.|.|..||..|||.|. ||.|.|||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLANTEEkEQFVMSAQYWPYkrGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTprdTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQqTG
|| ..||  . ...|||||   ||.| .|  .|||. . . .....|.|.|...     .|.| |.|| .|.||  |.|.. . ..|....|.. ..  .
mLtelee.lgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl...gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dp

NKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNS
..|.|||||||.||||.|.|. ...|... |. |.....||.|| ||...||...||.|.|.|.|.|    . 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
0036941 (Phosphotyrosine protein) phosphatases II 2660-2935 8.7e-88 289.7 In-house 10-282 (297) alignment 
Range on Protein: 2660-2935
Range on HMM: 10-282/297.0
EGETGYSHEFSRLQSERAhFDDFYSARNDANKDKNRLHNALPYDHNRVKLtkipGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVS
 . .... ||..|..  .   ... |.. .|..||| .. |||||.||||    .. ||||||||..|||. |. .||.|.|..||..|||.|. ||.|.
lflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

VIVMLANTEEKeQFVMSAQYWPYKRGEELAFGSASVTLQLTNH--QEDYIHRQLRVTYTPRDtppETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKR
||||| . .|. .... |||||.. ||.| .|  .|||. ...   .||. |.|.||.|  .   |.|.|.|| .|.||  |.|.. . ..|.|..|.|.
vIvmltelvel.grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng...esrtvthfhytgwpdhgvpespaslldfielvrkv

QQQT-GNKPILVHCSAGIGRTGAFCALSIAIERVK---VEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNS
.... ...|.|||||||.||.|.|.|. .......    |. |.|...||.||.||...||.|.||.|.|.|.|..  . . 
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_PTPRA_pd Subfamily PTPRA 2397-2654 1e-87 289.1 In-house 55-314 (330) alignment 
Range on Protein: 2397-2654
Range on HMM: 55-314/330.0
NPMNKLRNRYANIQCYDHSRVKLTPVEDSPH-DYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTvGrS
.  || .||. ||  ||.||| |...|  .. ||||| ||.||.. ..|||.|||. .|. |||||.|...| |.||||.|.|. . ||.|||||  | .
keenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde.G.l

ERFGPISVTFIKSTSHADYCIREFEIQ----TQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKrPMIIHCSAGVGRTGTFITIDSE
  .| | |.  ..|   || .|.| .|    ...||..| ..|||.|||||.||| .|  ...... |.. .. .   |...|||||||||||||..|. 
vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldav

MQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAEL
..|   || .. ..||...| .| .||||. |..||. .| |    | |.. .  || .. .|
lervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2662-2933 1.7e-87 288.5 In-house 21-286 (305) alignment 
Range on Protein: 2662-2933
Range on HMM: 21-286/305.0
ETGYSHEFSRLQSErahFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVI
..|. ...  |..|    . .   ...||| ||||..  ..|..|..||. . .  |||||||..|||| |..||.||.| .||..|||..| | .||.|
dkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLANTEEKEQFvMSAQYWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRdtPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQT
|||... | ..     |||| . .|.  ||. ||.|. ... .||| |.|...        |.|.| .. .|.||  | |   . ...||..|||.|.. 
vmltklveggkd.kCrqYWpesktekkefgefsvelksektasdyieRklkisiede..dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkd

GNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESL
 ..|.|||||||.||||.|.|..||.||.| | .|......|.||..|  |||.||||||.. |. .. .. 
kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
DSPc_SM00195 2666-2930 3.4e-87 287.5 In-house 3-262 (263) alignment 
Range on Protein: 2666-2930
Range on HMM: 3-262/263.0
SHEFSRLQSERAHFdDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLA
. ||..|.... .  .. .|. ..||.|||  | |||||.||||.|.... |||||||..|.|.. |. |||.|.|...|..|||.|. |..|..|||| 
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NTEEKEQfVMSAQYWPYKRGEELAFGSASVTLQLTNHQE-DYIHRQLRVTYTPRdtpPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTgNK
. ||...    ..||| . |..  ||. ||.|. ..... ..| |.|..|.. .    ||| |... ...|| .|.|.. . ...|. .|.|..... ..
eeeengk.ekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sg

PILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
||.||||||.||||.|....|...... |. |.| .|||.||.||..|||.|.|| |||.|||.|.
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2666-2930 3.4e-87 287.5 In-house 3-262 (263) alignment 
Range on Protein: 2666-2930
Range on HMM: 3-262/263.0
SHEFSRLQSERAHFdDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLA
. ||..|.... .  .. .|. ..||.|||  | |||||.||||.|.... |||||||..|.|.. |. |||.|.|...|..|||.|. |..|..|||| 
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NTEEKEQfVMSAQYWPYKRGEELAFGSASVTLQLTNHQE-DYIHRQLRVTYTPRdtpPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTgNK
. ||...    ..||| . |..  ||. ||.|. ..... ..| |.|..|.. .    ||| |... ...|| .|.|.. . ...|. .|.|..... ..
eeeengk.ekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sg

PILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
||.||||||.||||.|....|...... |. |.| .|||.||.||..|||.|.|| |||.|||.|.
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
Y_phosphatase Protein-tyrosine phosphatase 2400-2633 3.6e-87 287.0 Pfam-A 1-235 (235) alignment 
Range on Protein: 2400-2633
Range on HMM: 1-235/235.0
NKLRNRYANIQCYDHSRVKLtPVEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERFG
|| .||| .| .||..||||   ...|.||||||...||.....||||||||..||.|||||||.... ..||||.|.|| |.|| ||||.. ..|...|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PISVTFI-KST-SHADYCIREFEIQTQDEKT-TRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHkYTDKRPMIIHCSAGVGRTGTFITIDSEMQRAD
 |.|.   |..  ...|..|..|.. ..|.. .|..||.|||.||| |||..|..|...|. |....  ... |...||||||||||||...|  .....
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqle

QERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVE
.|.|.. .|.|...|..|..|||...|..|...|..|
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 2400-2633 3.6e-87 287.0 In-house 1-235 (235) alignment 
Range on Protein: 2400-2633
Range on HMM: 1-235/235.0
NKLRNRYANIQCYDHSRVKLtPVEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERFG
|| .||| .| .||..||||   ...|.||||||...||.....||||||||..||.|||||||.... ..||||.|.|| |.|| ||||.. ..|...|
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PISVTFI-KST-SHADYCIREFEIQTQDEKT-TRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHkYTDKRPMIIHCSAGVGRTGTFITIDSEMQRAD
 |.|.   |..  ...|..|..|.. ..|.. .|..||.|||.||| |||..|..|...|. |....  ... |...||||||||||||...|  .....
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqle

QERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVE
.|.|.. .|.|...|..|..|||...|..|...|..|
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0047943 (Phosphotyrosine protein) phosphatases II 2658-2930 2.1e-86 285.1 In-house 7-272 (273) alignment 
Range on Protein: 2658-2930
Range on HMM: 7-272/273.0
DDEGETGYSHEFSRLQSERAhFDDFYSARNDANKDKNRLHNALPYDHNRVKLtkipGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQ
.  | |..  || .|.|      ... |.  .|||||| .. |||||.||||    |. ||||||||..|||. |. .||.|.|..||..|||.|. ||.
kllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

VSVIVMLANTEEKeQFVMSAQYWPYKRGE-ELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDTppeTRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQK
|.||||| ...|. . .  ||||| . || .| .|  .|||  ... .||..|.|..|..  .    .|.|.|| .|.||  |.|.. . ....|..|.|
vrviVmLtelvel.grekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge...srtvthfhytgwpdhgvppslesllefielvrk

RQQQT-GNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
 .... .|.|..||||||.||||.|.|| ....... |. |.....||.||.|| .|||...||.|.|.|.|.|.
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2395-2637 3.5e-86 283.8 In-house 36-278 (281) alignment 
Range on Protein: 2395-2637
Range on HMM: 36-278/281.0
CLNPMNKLRNRYANIQCYDHSRVKLTPVED-SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVg
  .. |.|.||| ||  ||..|||.|| |. .  |||||||. ||. ..|.||||||.|... .||.|||...  ..||.|.  |. ..|| .||||   
skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn.

RSERFGPISVTFIKSTSHADYCIREFEIqTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEMQ
 . ..| . |........| |  |.|.. ....  ||...|..||.||| |||  .. |..| . |.. ..   | |..||||||||||||.|..|  ..
selkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvk

RADQE-RELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNT
....| .||.. . |...|..|| |||| .|. |.. |....|. 
aveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Ptp69D_pd Subfamily Ptp69D 2389-2653 3.6e-86 284.1 In-house 37-304 (307) alignment 
Range on Protein: 2389-2653
Range on HMM: 37-304/307.0
NPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVE-DSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQY
. |  |  .  |.|.||| .|. .|. ||||.... .   |||||.||.||.  ..||| |.|.  ||||||||... |. ..|||.||.|| | || .|
dkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakY

WPDTvgRSERFGPISVTFIKSTSHADYCIREFEIQTQDEK-----TTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTdKRPMIIHCSAGVGRT
||.      ..| | |..... .| || |||... ...|.      .| . |.|||.|.|. ||.... |...|. || ..|   . |...||||||||.
Wpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrs

GTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAE
|.|...|| .|.  .| ... ...|...|..|| .||  .|.||.. ||..  . |.||. ...|| .. .
gifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaier
0043336 (Phosphotyrosine protein) phosphatases II 2382-2633 4.5e-86 284.0 In-house 28-275 (278) alignment 
Range on Protein: 2382-2633
Range on HMM: 28-275/278.0
DINRSSPnPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSP-HDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKM
....  . .. ...| | || .||| .| .||||||||....  . .|||||... |||. ..|||||||||.|..|||||||.. ..|.||||.| |. 
ellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelg

RVKCTQYWPdtvGRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKyTDKRPMIIHCSAGVG
|||| ||||   | |...|...||..| ....||..| .|.    .. .| . ..||..|||.||| ....|..|...||.. . ... |...|||||||
rvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvg

RTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVE
||||||...  ..... |....... |...|| | ..|||. |..|...|| |
RTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 2661-2930 2.7e-85 281.7 In-house 30-289 (297) alignment 
Range on Protein: 2661-2930
Range on HMM: 30-289/297.0
GETGYSHEFSRLQSERAhfdDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGE-IGSDYINASFIDGYKA-KNCYIAAQAPKDNTLNDFWKMICEQQV
. |..  || .|.|      |.. |.  .||||||  . |||||.||||. ..|   .|||||||..|||.  .. .||.|.| ..|..|||.|. ||.|
sktllllefeellslkp...dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

SVIVMLANTEEKEQfvMSAQYWPYKRGeelAFGSASVTLQLTNHQEDYIHRQLRVTYtprdtPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQ
.||||| ...|...  . ||||| . |    .|  .|||  . | ..|..|.|.||.       |.| |.|| .|.||  |.|.. . .......|....
tvivmLtklvelgr..kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn.....ngesrtvthfqytgwpdhgvppslellleflelvreal

QQT-GNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
... ...|.|||||||.||||.|.|. ...|... |. |.....||.|| || ..||...||.|.|.|.|.. 
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0045450 (Phosphotyrosine protein) phosphatases II 2657-2929 3.1e-85 281.9 In-house 21-303 (307) alignment 
Range on Protein: 2657-2929
Range on HMM: 21-303/307.0
EDDEGETGYSHEFSRLQSERAH-FDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGE-IGSDYINASFI--------DGYKAKNCYIAAQAPKDNTL
.  .. ||.  || .|.|.  .  .....|.  .||||||  . |||||.||||. ..|.  .|||||||..        |||. |. .||.|.|...|.
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

NDFWKMICEQQVSVIVMLANTEEKeQFVMSAQYWPYKrGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTprDTPPETRVVHHFSFTSWPRSGAPSNGSG
.|||.|. ||.|.||||| ...|.  ... ||||| . |||| .|   |||  ..|...|..|.|.||..  |   |.| |.|| .|.||  |.|.. . 
edFwrmlweqgvtvivmltelvel.grekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl..dgtgesrtvthfhytgwpdhgvppsfee

MIDLIDQVQKRQQQT-GNKPILVHCSAGIGRTGAFCALSIAIERVKVEHI---VNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDY
..|.|..|.| .... ...|.|||||||.||||.|.|. ....... |..   |.....||.|| || ..|||..||.|.|.|.|..
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 2662-2929 1.6e-84 278.9 In-house 19-276 (278) alignment 
Range on Protein: 2662-2929
Range on HMM: 19-276/278.0
ETGYSHEFSRLQSERAhfDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVI
 |... || .|.|     |... |.  .||||||  . |||||.||||. ..|. .|||||||..|||. .. .||.|.| ..|..|||.|. |..|..|
ktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

VMLANTEEkEQFVMSAQYWPykrGEELAFGSASVTLQLTNHQEDYIHRQLRVTYtprDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQqT
||| . .|  . | .|||||   |. | .|  .|||. ..|..||..|.|.||.      .|.| |.|. ...||  |.|.. | ..|.. .|..... .
vmLtelve.lgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn...lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.d

GNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDY
 |.|.|||||||.||||.|.|| ...|... |. |.....||.||.||...||...||.|.|.|.|.|
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Ptp69D_pd Subfamily Ptp69D 2657-2934 7.9e-84 276.4 In-house 16-290 (307) alignment 
Range on Protein: 2657-2934
Range on HMM: 16-290/307.0
EDDEGETGYSHEFSRLQSErAHFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQ
 . . . |. .|. .|...     .   . .. |. ||| ... ..|..||||.||.|.  ||||||||| ||| |. .||||.| ..|..|||.|| ||
rkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeq

QVSVIVMLANTEEKEQFvMSAQYWPYKrgEELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDT--PPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQV
.| .||||.| .||..    |.|||    .|  .|.  |.|  .....|||.|.| |. .  ..   ...| |  ...|.|. | .|    |...||.||
evtlivmlsnlteknrk.kcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqv

QKRQQQTgNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLN
.. ...  . ||.|||||| ||.| | ||.. ....| |. |.|...||.|| ||  .||.|.||||.|||.||| .  .
relykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2394-2637 1e-83 275.4 In-house 3-244 (250) alignment 
Range on Protein: 2394-2637
Range on HMM: 3-244/250.0
VCLNPMNKLRNRYANIQCYDHSRVKLTPVE-DSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVkCTQYWPdtV
|. .| || .||||.|  .|.||| | ... |   ||||| |.|||.  . ||||||||..|| ||||||....| |.||||||.|. .. ..||||  |
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..v

GRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEM
 ..|..| . |.  ..  .||| .|.. .  . ..  | ..|.|...||| |||.. |  ..... |.. .......|.|..|||||||.|.||.||. .
ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

QRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNT
.|. .|. .. .......|..| |.|....|.||.. .. . |..
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPRK_pd Subfamily PTPRK 2393-2657 2.1e-83 274.8 In-house 36-300 (314) alignment 
Range on Protein: 2393-2657
Range on HMM: 36-300/314.0
DVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDS-PHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDT
|.. .  |. .||. .|  ||.|||.|.....    |||||..| .|.| ..||.|||||..|. ||||.|.|... ..||||.|.|..||||..|||. 
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

vgrSERFGPISVTFIKSTSHADYCIREFEIQT--QDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYtDKRPMIIHCSAGVGRTGTFITID
   .| .|.| |...... .|.. .| | ..   .  . .| ..||....|||..|| . | |..... |  ...  .. ....||||| |||||||.||
...tevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaid

SEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAEL-EIE
. .. ...|. .. .. |...|...  ||.|| |..||.|...|    |.| | . ...|   |  ...
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirld
0040439 (Phosphotyrosine protein) phosphatases II 2393-2635 9.3e-83 272.9 In-house 4-246 (249) alignment 
Range on Protein: 2393-2635
Range on HMM: 4-246/249.0
DVCLNPMNKLRNRYANIQCYDHSRVKLTPVED-SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDt
.|.| | || .||| .| .||||||||.....  ..|||||..|.||.. ..|||||||||.|..|||||.|.. . ..||||.|.|. |.|| ||||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

vGRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYT-DKRPMIIHCSAGVGRTGTFITIDS
 | |  .| ..||... ....||..|..|..   ....| .....||.|||.||| .. .|..||. || ..... .. |...|||||||||||||... 
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

EMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEIL
 ... . |....... |...|. |...||.. |..|...|| |.|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2392-2645 1.7e-82 271.9 In-house 41-289 (315) alignment 
Range on Protein: 2392-2645
Range on HMM: 41-289/315.0
VDVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSPH-DYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPD
.||  . .|| .||| ||  ||.|||.|  .|  || ||.||||| |||. . .||.|||.. ...||||.|....  ..|||||| |. . |. .||||
ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpd

TvgrSERFGPISVTFIKSTSHADYCIREFEIQTQDekTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDkRPMIIHCSAGVGRTGTFITIDS
       .|.|.|| ..   . .|..| . .  .|    | . |.||||||| |||.. .||...| ||..||. .   ....||||||||||||||.|.
k...kviyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitlda

EMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIE
 ...|. |. .. |.|....|.|| .|||. .|. ||.|||.| .  | | |  .
vldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqd
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2398-2658 6.6e-82 270.4 In-house 59-314 (319) alignment 
Range on Protein: 2398-2658
Range on HMM: 59-314/319.0
PMNKLRNRYANIQCYDHSRVKLTPVED-SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTnlqekmRVKCTQYWPDTVGRSE
. || .||. ||  .|...||| ...     ||||| |. || | . .||.||||..|. |||||.|.|.. |.|.||      . ||.||||  .   |
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

RFGPISVTFIKSTSHadYCIREFEIQT-QDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRR-HHKYTDKRPMIIHCSAGVGRTGTFITIDSEMQR
  . ..|. .. |.   | .|..|.     ||  |.|.|||.  ||| ||| .|..|..... ||  ..|  .......||||||||||..|..|  ..|
erfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldr

ADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAELEIED
 ..|. .. |.|||..|..||..||  .|. ||. ||.|    |..|. . .. | . ||  . 
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnks
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2391-2637 1.1e-81 269.1 In-house 38-282 (288) alignment 
Range on Protein: 2391-2637
Range on HMM: 38-282/288.0
SVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVE-DSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWP
||..  .. |. .||| ||  ||. ||||. .|  .  |||||..|.|.......|||||||.||..|||..|..... |.||||.| |. . || .|||
svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWP

DTvGRSERFGPISVTFIKSTSHADYCIREFEIQtqDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKyTDKRPMIIHCSAGVGRTGTFITID
|. .. ...| . || ..|    |.  |.....   .|| . |.|..|..||| |||.  .||......|   ..  |  |.|.|||||||||||||..|
da.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanq.adtgpiivhCsaGvGrtgtFiald

SEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEIL-NT
  ... ..|  ..   .| ..|..|. .|||. |..||...|...  . 
alidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
0045098 (Phosphotyrosine protein) phosphatases II 2387-2639 3.6e-81 267.9 In-house 20-276 (278) alignment 
Range on Protein: 2387-2639
Range on HMM: 20-276/278.0
SPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKltpvedsphDYINANFIHGYnrDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQ
... .. . | . |. .||| .|..|||||||         |||||..|.||  ...|||||||||.|. |||||.|.. ....||||.|.|. |.|| |
gipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPDtvGRSERFGPISVTFIKSTSHADYCIREFEIQTQ----DEKTTRSIKQFHYTSWPDFGVPRHP--TPLIQFIHTVRRHHK------------YTDK
|||.  | |...|...||... . . ||..| ....       . ..| ....||..|||.||| .|  .......  .|...|            . ..
ywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

RPMIIHCSAGVGRTGTFITIDSEMQRAdqERELNPYQFVRQMRENRNH-MVQTEAQFVFIHDALVEILNTGK
 |...|||||||||||.. ..  ...   |. ..... |...|. |.. .||.. |..|....|.|.|. ||
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2398-2657 4.4e-81 267.5 In-house 23-277 (284) alignment 
Range on Protein: 2398-2657
Range on HMM: 23-277/284.0
PMNKLRNRYANIQCYDHSRVKLTPVED-SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTnlqekmRVKCTQYWPDTVGRSE
. || .||. .|  .|...||| ..      ||||| || || | . .|||||||..|. |||||.|.|.. |.|.||      . ||.||||  .   |
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

RFGPISVTFIKSTSHadYCIREFEIQT-QDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRR-HHKYTDKRPMIIHCSAGVGRTGTFITIDSEMQR
  . ..|. .. ..   | .|..|.     ||  |.|.|||.  ||| ||| .|..|..... ||  ..|  .......||||||||||..|..|  ..|
erfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

ADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAELEIE
 ..|. .. |.|||..|..||..||  .|. ||. ||.|    |..|. . .. | . ||  .
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk
0042113 (Phosphotyrosine protein) phosphatases II 2394-2635 1.3e-80 265.6 In-house 3-243 (245) alignment 
Range on Protein: 2394-2635
Range on HMM: 3-243/245.0
VCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSP-HDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDtv
|.| | || .||| .| .|||.||||.|.. .. .|||||....||.. . |||||||||.|..|||||.|.. . |.||||.. |. |||| ||||.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

GRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEM
| | ..| ..||... ....||..|..|..   .. .| . ..||..|||.||| ..  |..|.. ||.. . ... |...|||||||||||||...  .
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

QRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEIL
.... |....... |...|. | ..|||. |..|...|| | |
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2392-2655 2e-80 265.3 In-house 40-308 (325) alignment 
Range on Protein: 2392-2655
Range on HMM: 40-308/325.0
VDVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSPH-DYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMlTNLQEKMRVKCTQYWPD
  |   | || .||. |.  .|.||| |   .|.|. |||||.... . . . |.|.| ||..||.|.||.| |.... ||. .|  ..   .|..|||.
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavywpk

TVGRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDK-----RPMIIHCSAGVGRTGTF
 .| | .||.. | ..     .||  | ....  ..  |||.|||.. ||.|.||...|. || ....|   ..          |...||||||||||.|
emgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvf

ITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAELE
|.. | ...  .| ... ..||...|..|  ||.|  |...|..|||| . .|.||. .  .||... |.
islysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslq
Y_phosphatase Protein-tyrosine phosphatase 2690-2927 4.3e-80 263.9 Pfam-A 1-234 (235) alignment 
Range on Protein: 2690-2927
Range on HMM: 1-234/235.0
NKDKNRLHNALPYDHNRVKLtkiPGEIG-SDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYKRGEEL
||.||| .. ||||..||||    |. | ||||||....||| |. .||.|.| ..|..|||.|. ...|.|||||.. |||.. .  ||||| ...|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr.ekcaqYwpeeeeesl

AFGSASVTLQ--LTNHQEDYIHRQLRVTYTPRDTppETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQqQTGNKPILVHCSAGIGRTGAFCALSIA
 .|. .|.|.   ......|. |.|... . ...  |.| |... .|.|| .|.|.. ....|||..|.|.. .. ..|..||||||.|||| |.||.|.
tygdikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldil

IERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAIL
.|... |. |....|||.||.||..|||.|.||.|.|.|||
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 2690-2927 4.3e-80 263.9 In-house 1-234 (235) alignment 
Range on Protein: 2690-2927
Range on HMM: 1-234/235.0
NKDKNRLHNALPYDHNRVKLtkiPGEIG-SDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYKRGEEL
||.||| .. ||||..||||    |. | ||||||....||| |. .||.|.| ..|..|||.|. ...|.|||||.. |||.. .  ||||| ...|.|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr.ekcaqYwpeeeeesl

AFGSASVTLQ--LTNHQEDYIHRQLRVTYTPRDTppETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQqQTGNKPILVHCSAGIGRTGAFCALSIA
 .|. .|.|.   ......|. |.|... . ...  |.| |... .|.|| .|.|.. ....|||..|.|.. .. ..|..||||||.|||| |.||.|.
tygdikvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldil

IERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAIL
.|... |. |....|||.||.||..|||.|.||.|.|.|||
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2685-2938 6.3e-80 263.0 In-house 4-250 (250) alignment 
Range on Protein: 2685-2938
Range on HMM: 4-250/250.0
ARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQFvmSAQYWPYKR
|.. .||.|||  . ...|. || | |  |.  ||||||||..||. .. .||.|.|  .|..|||.|. |.....||||.| .|.|.     |||| ..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt..yhqywPvek

GEElaFGSASVTLQLTNHQEDYIHRQLRVTytpRDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALS
 |.  .|.  |.|  ...  ||..|.| ..   . .  . |.| ...|..||  | | .   ...|...||. |||.||.|..|.||||.||.|||.|..
aek..yGdvtvsllskeefadytkrklkls...kakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid

IAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNSYAN
  .||.| |..|......| ||..| |.|. |.||||.|..|| . .|.. ||.
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_PTPN9_pd Subfamily PTPN9 2382-2634 1.3e-79 262.3 In-house 24-289 (297) alignment 
Range on Protein: 2382-2634
Range on HMM: 24-289/297.0
DINRSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVED-SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKM
.| . ...  ...   ..|  .|||... |||..||.|. |.. .  |||||||. ||.. . ||||||||. |. |||||||. |  ..|| | . |. 
eirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvverg

RVKCTQYWPDTVGRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKY------------TDK
|.||.||||.. . |..|| .||. ..  .. || .| .||.  ... .|..  | ..||||.|||.  . |......||..               ...
rlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsg

RPMIIHCSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEI
 |...|||||.||||||||.|  ..| ...  ..  . |...|. | ...||. |..| . |..| 
PPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_PTPN12_pd Subfamily PTPN12 2395-2636 2.1e-79 261.4 In-house 35-278 (290) alignment 
Range on Protein: 2395-2636
Range on HMM: 35-278/290.0
CLNPMNKLRNRYANIQCYDHSRVKLTPVEDSP-HDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVG
  .. |. .||| .|  ||.|||.|.  |...  ||||||||.| . . |.||.|||||.|. |||||.|...   |||. .. |  . || .|||....
gekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

RSERFGPISVTFIKSTSHA-DYCIREFEIQTQdeKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKyTDKRPMIIHCSAGVGRTGTFITIDS--
.. .||...|| ..      |. || .....|  |..|...|||||.||| |||. ...|...|..||.... ... |...||||||||||| |.||   
eelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvr

-EMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILN
  ...   . ||. .. |...|..|. .|||. |..... |..|...
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2638-2928 2.5e-79 261.9 In-house 7-289 (319) alignment 
Range on Protein: 2638-2928
Range on HMM: 7-289/319.0
GKTDIGIEQLEARMAELEIED--DEGETGYSHEFSRLQSERAHFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCY
|..|. .....|   .| . .  |.  | .  || |.    .   |   |  | ||||||. | |..|.|.||| .. || .||||||||..||. |. |
gesdvavpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdky

IAAQAPKDNTLNDFWKMICEQQVSVIVMLAnteekeqFVMSAQYWPYKRGEElaFGSASVTLQLTNHQEDYIHRQLRVTYTPRDTppETRVVHHFSFTSW
|||| |.||||.|||.|| |...| ||.|.         . .|||| |  ..   .   | ... .  ..|. |.....   . .  . | .. | |  |
iaaqGPldntladfWrmiweyncstivllt.......kdkcsqywplkivik..eerfkvkvdsveetaeyvvrdielsedgkek..dirkitqfhflGw

PRSGAPSNGSGMIDLIDQVQK-RQQQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILD
|  | |  .| .. |...|.. .... ....|.||||||.||||.. .| . ..|.| |. |..||.|. || || ..||.| || ||| |.|.
pdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0040439 (Phosphotyrosine protein) phosphatases II 2681-2929 6.3e-79 260.4 In-house 2-245 (249) alignment 
Range on Protein: 2681-2929
Range on HMM: 2-245/249.0
DFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKeQFVMSAQYW
... |.  .|||||| .. |||||.||||. .||  .|||||||.||||. |. .||.|.| ..|..|||.|. |....||||| ...|. ...  ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel.grekcaqyw

PYkrGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTprdTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQT-GNKPILVHCSAGIGRTGA
|   |..| .|  .|||  ... .||..|.|..|..     .|.| |.|. .|.||  |.|.. . ..|.|..|.| ....  ..|.|||||||.||||.
pl..ggsleygdftvtllsvevkddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

FCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDY
|.|. ...|... |. |.....||.||.|| ..|||..||.|.|.|.|..
fiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPN9_pd Subfamily PTPN9 2659-2934 7e-79 259.9 In-house 12-294 (297) alignment 
Range on Protein: 2659-2934
Range on HMM: 12-294/297.0
DEGETGYSHEFSRLQSERAhFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQV
..|. | |.|.  ...| .    |. ..  ||  ||| .. | ||. ||.|.|....  ||||||.|.|||| |...||.| | ..| .|||.|. ||.|
ekgkrGlskeyaeirnepv.eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqev

SVIVMLANTEEKEQfVMSAQYWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDtppETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQ
 |||| . ..|. . .  .|||| ....   ||. ||.   ....||| .|.| .. .  .   |.| | || |.|||  | ||... ..|....|...|
lvivmttrvvergr.lkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkte...esrkvthfqflsWPdyGvPssaaslldvlekvrekq

QQ------------TGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLN
 .            . . ||.|||||||||||.|..| |...|.. .  |.. . ||.||||||...|  .||.| | |.|.|| .|.
alavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalelk
subfamily_PTPRB_pd Subfamily PTPRB 2642-2932 1.6e-78 258.8 In-house 7-287 (293) alignment 
Range on Protein: 2642-2932
Range on HMM: 7-287/293.0
IGIEQLEARMAELEiedDEGETGYSHEFSRLQSERaHFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAP
| .|..|. .....    . ....|.|...|..   .     .|.. .|..||| .| |||||.||||... .| |||||||..|.||.... .||.| |
iklekfeehvkkmk...adsdlrfseeyeelkavg.kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

KDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYKRgEELAFGSASVTLQLTNHQEDYIHRQLRVTYtprdtPPETRVVHHFSFTSWPRSGAP
  .|..|||.|. |...|.|||| .. || . |   .||| .. |. ..|. .|||. ....||.. |.|...        |.| |... |||||  | |
lpetvddfWrmvwekkssiivmltqlvekgk.vkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek.....ekeerkvrqyhftsWpdhgvP

SNGSGMIDLIDQVQKRQ-QQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAES
.. . ..|.. .|.... ... ..||.||||||.||||.| ||   ..... | .|.|. || .||..|...||. .||.||....||. ..
ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPN6_pd Subfamily PTPN6 2394-2637 3.9e-78 257.5 In-house 48-299 (306) alignment 
Range on Protein: 2394-2637
Range on HMM: 48-299/306.0
VCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSPHDYINANFIHG--YNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDT
    | || .||| ||  .||.||.|.  . . .||||||.|..   . |...||||| |..|. |||||||. .|  .||.|.  |. . ||..||||.
egakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde

VGRSErFGPISVTFIKSTSHADYCIREFEIQ-TQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTD---KRPMIIHCSAGVGRTGTFIT
  ..| .| |||| ....|.||| .||. .. ....|..|.. |.|..|||| |||..|  ...|...|.|.....    ..|...|||||.||||||| 
eekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiv

IDSE---MQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNT
||     ...   . ... ...|...|| |. .||||.|. |.. |. . ..|
iDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
0042113 (Phosphotyrosine protein) phosphatases II 2685-2929 7.6e-78 256.6 In-house 4-242 (245) alignment 
Range on Protein: 2685-2929
Range on HMM: 4-242/245.0
ARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEkEQFVMSAQYWPYkr
|.  .||||||  . |||||.||||. ..|. .|||||||..|||. .. .||.|.| ..|..|||.|. |.....|||| ..||  ..| .|||||   
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeee.lgrvkcaqywpl..

GEELAFGSASVTLQLTNHQEDYIHRQLRVTYTprdTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALS
||.| .|  .|||  ..| .||..|.|.||..     .|.| |.|. ...||  |.|.. . ..|... |.| .....|.|.|||||||.||||.|.|. 
gesltygdftvtllseehlddytvrtlevtnl...gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

IAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDY
...|... |. |.....||.|| || ..||...||.|.|.|.|..
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2654-2932 9.3e-78 256.2 In-house 12-283 (288) alignment 
Range on Protein: 2654-2932
Range on HMM: 12-283/288.0
LEIEDDEGETGYSHEFSRLqSERAHFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMI
  . . ...||.|.|.  | ..  . ..   .|.  |..||| .| ||||..||||.| . | |.||||||.|||.| |. |||.|.|  .|.||||...
vakksarnrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

CEQQVSVIVMLANTEEKEQFvMSAQYWPYKrGEELAFGSASVTLQLTNHQEDYIHRQLRVTytprdTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQ
 |...| ||||..  |...     .||| . ...  .||  |||. ....||...|.| .         . . .... ...||  | | .   ...|..|
yenktstivmltelveggkt.kCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle.....kkkteleitqyqylaWpdhgvPeskapllellrq

VQKRQQQTgNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA--ES
|.  .|.   .||.||||||.|||| | ||  .|..|. |  ... ..|..|| ||| .||.| ||.|||...|. .  ..
vkvanqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2394-2674 1.7e-77 255.7 In-house 37-316 (515) alignment 
Range on Protein: 2394-2674
Range on HMM: 37-316/515.0
VCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSPH-DYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTV
|. . .|  .||| ||  || .||||  ..|.|| ||.|| .|.... |. .||.|||.. .. ||||.|....  |..|.|.|.|  ..||..||||  
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

GRSERFGPISVTFIKSTSHADYCIREFEIQTQDEktTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHK-YTdkRPMIIHCSAGVGRTGTFITIDSE
| | .|| |.|  .   . ..  .|....  .|.  .| . |||.| ||| |||.| . |...|. |.  |  ||   |.|||||||||||| .|.||| 
gdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsv

MQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAELEIE-DDEGETGYSHEFSRLQS
. .| . | .. ..||...|..| ..|||. |. ||..|. | |   .| | . ..   . .|    | .| .   .||  |.|
vahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlks
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2393-2657 4.7e-77 253.9 In-house 37-299 (315) alignment 
Range on Protein: 2393-2657
Range on HMM: 37-299/315.0
DVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSPH-DYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDT
 |. ...|  .||| ||  .|..||||  ..|||. ||||| .|.... |. .||.||||. .. ||||||....  |.||.|..||  ..|| ||||| 
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

VGRSERFGPISVTFIKSTSHADYCIREFeiQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKyTDKRPMIIHCSAGVGRTGTFITIDSE
 . | .|| |.|. ..  . .|  .|..   |.. ...| . ||..| ||| ||... . |...|. |.  .. ... ....|||||||||| .|.||. 
kadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadng.kkefsllvhcsaGvGrtGvvisidev

MQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAELEIE
.... ..| .. ..||...|..| ..|||| .. ||.||. | |   .| | . ..  .. .|   
vaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhts
0037934 (Phosphotyrosine protein) phosphatases II 2394-2634 1.5e-76 252.4 In-house 4-241 (243) alignment 
Range on Protein: 2394-2634
Range on HMM: 4-241/243.0
VCLNPMNKLRNRYANIQCYDHSRVKLtpvEDspHDYINANFIHGYNRdneFIATQGPLPDTIGD----FWRMVWDYESPTVVMLTNLQEKMRVKCTQYWP
..| |.|. .||| .| .||||||||   |.  .||||||.| ...|   .||||||||.|. |    ||||.|.. . ..||||.|.|. |.|| ||||
iallpenlsknrysdilpydhsrvkl...eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dtvgRSERFGPISVTFIKSTSHADYCIREFEIQTQD-EKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKY-------TDKRPMIIHCSAGVGR
     ....|...||........||..|.....  | .. || . ..||..|||.||| .|..|..|.. || . .         ...|...||||||||
....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTFITIDSEMQRAdqerELNPYQFVRQMRENRNH-MVQTEAQFVFIHDALVEI
|||.|...  ...     ...... |...|| |.. .|||. |..|...|| |.
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2668-2928 1.7e-76 252.5 In-house 3-253 (284) alignment 
Range on Protein: 2668-2928
Range on HMM: 3-253/284.0
EFSRLQSERAHFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLAnt
|| |.    .   |   |  | ||||||. . |..|.|.||| .. || .||||||||| ||. |. |||.| |.||||.|||.|| |...| ||.|.  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

eekeqFVMSAQYWPYKRGEElaFGSASVTLQLTNHQEDYIHRQLRVTYTPRDTppETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQK-RQQQTGNKPI
       . .|||| |  ..   .   | ... .  |.|. |.....   . .  . | .. | |  ||  | |  .| .. |...|.. .... ....|
.....kdkcsqywplkivik..eerfkvkvdsveeseeyvvrdielsedgkek..dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhrani

LVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILD
.||||||.||||.. .| . ..|.| |. |..||.|. || || ..||.| || ||| |.|.
vvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2658-2936 1.9e-76 251.7 In-house 15-289 (290) alignment 
Range on Protein: 2658-2936
Range on HMM: 15-289/290.0
DDEGETGYSHEFSRLQSERAHFdDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGE--IGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICE
  .|..|. ..| .|.|   ..   . .    || .|| .| ..|| ||. | .|.|.     .||||..|.||| |. |||.|.|  ||| ||||.| .
hakgnegfrnqfkmldsgeseh.tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwq

QQVSVIVMLANTEEKEQfVMSAQYWPYKrGEELaFGSASVTLQLTNHQEDYIHRQLRVTYTPRDtpPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQ
..|..|||| |  |... |   |||| . . .  .|  |..|.  .. ..||.|.|.|. .  .   ... |... .|.|.  |   | .... .| ...
ekvtiivmltniieegk.vkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillvieemy

KRQQQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNSY
| | ..||..|.||||...||.. |||. ..|...| |  .......|..|.|.  .||  .|| .|.. .| | .|.. |
ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_PTPN12_pd Subfamily PTPN12 2658-2931 2.9e-76 251.1 In-house 3-278 (290) alignment 
Range on Protein: 2658-2931
Range on HMM: 3-278/290.0
DDEGETGYSHEFSRLQSERA--HFDDFYS---ARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKM
. |||  ...||..|... .  . .. ||   .... |. ||| .. ||||..||.|.|| .| |||||||.|| | . |  |||||.|  .||.|||.|
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

ICEQQVSVIVMLANTEEKEQFvMSAQYWPYKRGEELAFGSASVTLQLTNHQ-EDYIHRQLRVTYTprdtpPETRVVHHFSFTSWPRSGAPSNGSGMIDLI
| |..|...||. .  | ...   ..||| . .||| ||. .|||.  ..  .|.. |.|.|.        |.|.|. | .|.||  | ||. . ...||
iweknveivvmaCrevelgkk.kCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.....kesrkvyqfhYtaWPDhgvPssakslleli

DQVQKRQQqTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHI---VNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAE
..|...|. . ..|..||||||.||||. .|. .. | .| |.|   ......| .||.||| .||  .||...|.|.... .
elvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN3_pd Subfamily PTPN3 2383-2635 3.3e-75 247.6 In-house 24-275 (280) alignment 
Range on Protein: 2383-2635
Range on HMM: 24-275/280.0
INRSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTpveDSPHDYINANFI----HGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQE
. |  |. .....  | |  .||| .|  ||. ||||.   .|. ||||||..     . .  | .|||||||..|  |||.|||. .| ..||||.| |
lyrkkpglaisaarkpenlsknryrdilpydatrvklk...esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlve

KMRVKCTQYWPDtVGRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRhHKYTDKRPMIIHCSAG
. |||| ||||.  . . ..| .||.  |. ..  |..||. .. ...|  |.| |. |..||| ||| ... ...|...||.  . ....|...|||||
rGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrk.lrsgkeePvvvhCsaG

VGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEIL
.|||| .|...  ..  .......| . ||.||. |  .|||..|. |. .|.... 
igrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_PTPN23_pd Subfamily PTPN23 2652-2934 1.2e-74 245.8 In-house 4-284 (288) alignment 
Range on Protein: 2652-2934
Range on HMM: 4-284/288.0
AELEIEDDEGETGYSHEFSRLQSERA-HFDDFYSARNDANKDKNRLHNALPYDHNRVKLTkipgEIGSDYINASFIDGYKAK-NCYIAAQAPKDNTLNDF
.||. .  .|.|.  ..|  |... . .  ..  |    . .||| .. ||||||||||     .   |||||||. .  .   ..||.|||...|||||
eelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WKMICEQQVSVIVMLANTEEKEQFVMSaQYWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDTppeTRVVHHFSFTSWPRSGAPSNGSGMID
|.|. ||..|||||| . ||...  .. .||| ..||   ||  ||||. ... | ...|.|...  . |.   .. | |  .||||  |.|.  . ...
WlmvyeqkssviVmllskeelgkpkvd.rYwPedkgetvkfgdlsvtlksvretethvervlkletldada...vksvshlqltsWpelGvPasPetllq

LIDQVQK---RQQQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEH-IVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLN
..|.|..    .|.  ..|..||||||.||||.|. .  |.. ..... ...| ..|..||.|| .|||. .|. | | |.| .|.  .
fldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_PTPRK_pd Subfamily PTPRK 2676-2928 1.9e-74 245.3 In-house 29-275 (314) alignment 
Range on Protein: 2676-2928
Range on HMM: 29-275/314.0
RAHFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTeEKEQFVM
 . |. . .|..| |..||| .. |.||. ||.|. | |.  ||||||..||.||  . .|..| |...|..|||... ... . ||||..   ... | 
eslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltel.vevgrvk

SAQYWPYKrGEElaFGSASVTLQLTNHQEDYIHRQLRVTYTPRDTpPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQtGNKPILVHCSAGIG
  .||| . .|   .|   |.|  |. ......| .||. . |    |.|.|..| |..||  . | .  |...|. .|.| |.. .. .|.|||||| |
ClkyWPed.tev..ygdikvelvetellaelvvrifrveklargq.eeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaG

RTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILD
|||.|.|..| .. .. |..|...|.|| ||...  ||.  .||.||| .||.
rtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
0045098 (Phosphotyrosine protein) phosphatases II 2679-2931 2.6e-73 242.1 In-house 22-273 (278) alignment 
Range on Protein: 2679-2931
Range on HMM: 22-273/278.0
FDDFYSARNDANKDKNRLHNALPYDHNRVKltkipgeigsDYINASFIDGYkaKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQFvMSAQ
..... |    |.|||| .. |||||.|||          ||||||.||||  .. .||.|.|...|..|||.|. |....|||||.. .|...    ||
pseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre.kcaq

YWPyKrGEELAFGSASVTLQLTNHQEDYIHRQLRVTYT-PRDTPPETRVVHHFSFTSWPRSGAPSNG--SGMIDLIDQVQKRQQ------------QTGN
|||   |. | .|  .|||. . . .||..| |.||..  ...  |.| |.|. ...||  |.||.   . ...|.........            . ..
ywp.e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

KPILVHCSAGIGRTGAFCALSIAIERVkvEHIVNIYNIVKHLRTQRAH-MVQNLDQYVFIYRAILDYAE
.|.|||||||.||||...|. . .|..  |. |.....||.||.|| . .||||.||.|.|...|.. .
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2398-2645 1e-72 239.8 In-house 49-294 (297) alignment 
Range on Protein: 2398-2645
Range on HMM: 49-294/297.0
PMNKLRNRYANIQCYDHSRVKLTPVEDSP-HDYINANFIHGYNRdnEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRvKCTQYWPDTVGRSe
 .|  ..||.||  || |||||  |.|.|  ||.|| |..|..   ..|.|| | ..|. |||.||.|..  |.|||....|. . ||..||.|.   . 
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.

rFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPR--HPTPLIQFIHTVRRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEMQR
 || .||.    ..   .  ||.|.. .. |..| .||.....|||  |.|  . . |...|. || ... . . |...||.||||||| ..|||| . .
.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvae

ADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIE
| .| |.. ...|...|..| ..|||. |. |.. |..| | . .|.| ..
akrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2398-2634 1.8e-72 238.8 In-house 26-267 (274) alignment 
Range on Protein: 2398-2634
Range on HMM: 26-267/274.0
PMNKLRNRYANIQCYDHSRVKLTP--VEDSPHDYINANFIHGYNRD-NEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGR
. .. .||| .|   ..||| |..  .||.  .|||||.|.||... . ..||||||| |. |||||..  |.. .||||.|.|. . ||..|.||. . 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

--SERFGPISVTFIKSTSHADYCIREFEIQTQDEktTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKR--PMIIHCSAGVGRTGTFITIDS
  |||.| ..... | ... || .|.. .. . .  .||.| . ||.|||  .|.....|..... |.. .. ....  |...|||||.|||| ||.|. 
eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

EMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEI
 ... ..|  ..  . | ..| .|  ||||. |. .|| ||.. 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2657-2939 3.5e-72 237.8 In-house 14-287 (287) alignment 
Range on Protein: 2657-2939
Range on HMM: 14-287/287.0
EDDEGETGYSHEFSRLQSERAHFDDFYSARNDANKDKNRLHNALPYDHNRVKLTkipgEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQ
. ..|..|... |  |..   . |.   .    |||||||.. |..| .|| |     .   |||||.|||||| |. .|.|..|  ||. .|||.| ..
ghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddr

QVSVIVMLANTEEKEQFVmSAQYWPYKRGeeLAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDTPPetRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQK
.|..||||.. .|... |   |||| ..   . .|  ...|   .....|| |.|.|. . .....  . |. . .|.|.  |  ..   .. .|..  |
nvtaivmlcqekendeev.cyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdk..qqvkqyqitnWdstgkvtepqtillvieemyk

RQQQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNSYANF
 |.. || .|.||||...||.. |||  ..|...| | ........|. | |. ..||  .|| ||. ..| | .| . |..|
tqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_PTPRG_pd Subfamily PTPRG 2644-2932 4.7e-72 238.0 In-house 3-289 (563) alignment 
Range on Protein: 2644-2932
Range on HMM: 3-289/563.0
IEQLEARMAELEIeddEGETGYSHEFSRLQSERAHFD-DFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGS-DYINASFIDGYKAKNCYIAAQAP
.....  .|.|     .|..|.|.||  |||| .. | |  ....  || |||  | ..||. ||||...||. .. |||||..||||. .. .||.| |
vkefakhvaslha...dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgp

KDNTLNDFWKMICEQQVSVIVMLANTEEKEQFvMSAQYWPYkrGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTP---RDTPPETRVVHHFSFTSWPRS
  .|..|||.|| ||.|..|||..| .|...     .|||    | . .|. .|||. ...   |  |.| .  .     .   . ..| .. .|.||  
lkdtfddFWrmiWeqnvaiivmitnlvergrr.kcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdh

GAPSNGSGMIDLIDQVQKRQqQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAES
|.|.     .  . . .. . ..   ||.||||||.|||| ...|.  ..... |..||.....||.|.|| ..||. .||.|.. |.|.   |
gvPehslpvLifvkkssaan.kaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2657-2931 7.1e-72 236.9 In-house 9-277 (281) alignment 
Range on Protein: 2657-2931
Range on HMM: 9-277/281.0
EDDEGETGYSHEFSRLQSERAHfDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQ
.... ..|. .|.. |..   . .   ....|.|. ||| .|   ||. |||.|.   .  .|||||.|..||| .. |||.|.|  ..|..||.|. ||
lsqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

QVSVIVMLANTEEKEQfVMSAQYWPyKRGEELAFGSASVTLQLTNHQEDYIHRQLRVtytpRDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQK
.||.|||...  |... .   .|||    .|| .|   |. . ..... ||.|....    . .  ||| |... .|.||  |.|.. . ...  ..|.|
kvsaivmvtreieagk.lkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl....eresgetreveqlaytaWPdhGvPattkellefrkevlk

RQQQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVE-HIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAE
 ...  . |...|||||.||||.. ||  ....|. | . ... ..|..|| .|  ||| . || |.|.|.||. .
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN6_pd Subfamily PTPN6 2644-2935 1.6e-71 235.9 In-house 6-302 (306) alignment 
Range on Protein: 2644-2935
Range on HMM: 6-302/306.0
IEQLEARMAELEIEDD-EGETGYSHEFSRLQSE-RAHFDDFYSARNDANKDKNRLHNALPYDHNRVKLTkIPGEIGSDYINASFIDG--YKAKNCYIAAQ
 ...| |. ||| |..  . .|.. || .|| |   .  .   ..   || ||| .| ||.||.||.|.  |. .|||||||..|..   . ...|||.|
akeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatq

APKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYKRGEELaFGSASVTLQLTNHQEDYIHRQLRVTYTprDTPPETRVVHHFSFTSWPRSG
   ..|..|||.|. ...  ||||. .  |. .  . |.||| .  .|  .|. |||    ....||| |.|.|. .  ..  |.| |... |.|||  |
gclettvsdFWrmvwqensrvivmttkevErgk.ekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk..kkkkeerevfqyhfksWPdhg

APSNGSGMIDLIDQVQKRQQQTG---NKPILVHCSAGIGRTGAFCALSIAIERV---KVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESL
 |.. . ..|....|...|...    . ||.|||||||||||.|  . | .. .   ...  ..|...|| .|.||  .||  .|| |.|.||  | |. 
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk

NS
..
kk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2387-2638 5.3e-70 230.6 In-house 33-286 (290) alignment 
Range on Protein: 2387-2638
Range on HMM: 33-286/290.0
SPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVE---DSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVK
. . .| | | . |||.||.|||  ||  |. | |.    | ...|||| .|.||. ....||||||...|. |||...|. ... .||||| .|. .||
esehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvk

CTQYWPDTvgRSERFGPISVTFIKSTSHADYCIREFEIQTQDE-KTTRSIKQFHYTSWPDFG-VPRHPTPLIQFIHTVRRHHKYTdKRPMIIHCSAGVGR
| |||||.   ....|..|.. .. ... .| .|..|.. ... ....|..|.. |.|.. | |. . | |... . .. ..| . ......|||..|||
CqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHCSdtvgr

TGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTG
...|....  .... .|   . .| ....|  .  .|||. |. .|.. ... |.. 
savfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_PTPN13_pd Subfamily PTPN13 2389-2637 7.2e-69 227.1 In-house 26-271 (273) alignment 
Range on Protein: 2389-2637
Range on HMM: 26-271/273.0
NPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTpvEDSPhdYINANFIHGYNRDNE--FIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQ
  ...|  .  || .||| |.  ||..||||   ....  ||||..|.    ..|  .||.|||||.|. |||.|||. ..  ..|.|. .|| .||| .
ldtcevgkkkenkdknryrnvlPydetrvklg..degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchr

YWPDTVGRSERFGP-ISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKytDKRPMIIHCSAGVGRTGTF
|||.. ...      . |. .| . . .. .|..... .. . .| . ......||| |||.....|.||.  ||| ..  |. |...|||||.||.||.
ywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrsGtl

ITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNT
||||  ..  ....|..  . ||..|| |. .|||. |..|.. |..|.|..
itidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
0037934 (Phosphotyrosine protein) phosphatases II 2683-2929 8.6e-69 227.1 In-house 3-241 (243) alignment 
Range on Protein: 2683-2929
Range on HMM: 3-241/243.0
YSARNDANKDKNRLHNALPYDHNRVKLtkiPGeigSDYINASFIDGYKaknCYIAAQAPKDNTLND----FWKMICEQQVSVIVMLANTEEKeQFVMSAQ
. |.  .|..|||  . |||||.||||   .|   ||||||..|....    .|| |.| ..|..|    ||.|. |....||||| ...|. . .  ||
siallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvEl.grekcaq

YWPykrGEElAFGSASVTLQLTNHQEDYIHRQLRVTYtpRDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQ-------TGNKPILVHCS
|||   ||.  .|  .|||  ..| .||..| |....   |....|| |.|. ...||  |.|.. . ..|..|.|.. ...        ...|.|||||
ywp...gev.tygdftvtllseehlddytvrtlllen..ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

AGIGRTGAFCALSIAIERVkveHiVNIYNIVKHLRTQRAH-MVQNLDQYVFIYRAILDY
||.||||...|. . ....   . |.....||.||.|| . .||...||.|.|.|.| .
aGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2681-2928 1e-68 226.6 In-house 40-277 (315) alignment 
Range on Protein: 2681-2928
Range on HMM: 40-277/315.0
DFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYW
 .  |..  ||.||| .| ..||. ||.|  .  . .|||.||.|||||. |. |||||.|. ....|||... |.... ||||.|. |.|.  .. .||
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegek.rkaekyw

PYKrgeELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRdtppeTRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTGnKPILVHCSAGIGRTGAF
| |   .. .|  .||..  .....|  | | |..  .      | |  . .|||| .| |     ...|| .|.. ....   .|.||||||.||||.|
pdk...kviyGkitvtrkseevnteytvrtlsvvfgdn.....irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtf

CALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILD
..|.  ......|.....||... .| .| .||| ..|| ||| |.|.
itldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2666-2931 5.4e-68 224.1 In-house 22-278 (315) alignment 
Range on Protein: 2666-2931
Range on HMM: 22-278/315.0
SHEFSRLQSERAHfdDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLA
|.||  |    ..     .||.. |  ||| .| ||.|..||||  |  .  |||||||.| ...  ..|||.|.|.. ...|||.|. ...|. |||..
seefhdlpdPdiy..rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt

NTEEKEQfVMSAQYWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLrVTytpRDTpPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRqQQTGNKP
. .| .. .  .|||| ....   ||| .|.|  .. . | ..|.| ||   |..  |.| |  | || ||  |.. . | .. || .|.   ... . .
kkqegdk.ikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt...rks.eesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefs

ILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAE
.|||||||.|||| ....   ....| .. |...|.|| ||..| ..||  ..| ||| |.|..  
llvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN1_pd Subfamily PTPN1 2382-2646 2.3e-67 221.8 In-house 14-282 (290) alignment 
Range on Protein: 2382-2646
Range on HMM: 14-282/290.0
DINRSSPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDsphDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMR
||.. . . .. .. .| |. .||| ... |||||.||   .    |||||....  . . ..| ||||||.|.. ||.|||. .| .|||| .. || .
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeq

VKCTQYWPDTVG-RSERFG--PISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKY-TDKRPMIIHCSA
.||.||||     ..  .    ..|..|.  ..  | .| .|.. .  . ||.| .||||.|||||||. |. ...|.. ||.     .|. | .|||||
ikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

GVGRTGTFITIDSEMQRADQERE---LNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQ
|.||.|||. .|. . . ... .   ..  . . ..|. |  ..||  |. | . |..|  .. |.|  ...
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2661-2941 8.2e-67 220.6 In-house 21-299 (325) alignment 
Range on Protein: 2661-2941
Range on HMM: 21-299/325.0
GETGYSHEFSRLQSERAHfdDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSV
 . |..|||  | |. .    .  |   .||.|||..| ...|..|| |     .  |||||||..  .| |. ..|||||. .|.||.|..... . ||
dqdgfahefgllpsddgi..akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsv

IVMLANTEEKEQfvMSAQYWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDtppETRVVHHFSFTSWPRSGAPSNGSGMI---DLIDQVQKR
.|.|   .....    |.||| . |.   ||.  | |.  ..  ||.||.| |  . .    ||| |. | . ||.  | .   . .|   .|...|..|
vvvlneldlgkd..rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG...etrsvkqfqlqswddmGvqkrpatlisilqlvkavser

QQQ--TGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNSYANFNS
 .    .  |||||||||.||||.| .|  |...|  |  |.|.. ||.|| .|  ||.  |||..|| |. ..  | |.    .|
vtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvss
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2684-2934 1.3e-66 219.7 In-house 45-288 (297) alignment 
Range on Protein: 2684-2934
Range on HMM: 45-288/297.0
SARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAknCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfvMSAQYWPYK
 |..  | .|.| .| |||| .||||  .  .  |||.||||. |.|    .|. | |...|..|||.|. ..|||.||||.. .|...    |.||. |
vaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk..kcaryWsdk

RGEElaFGSASVTLQLTNHQEDYIHRQLRVTytpRDTPPETRVVHHFSFTSWPRSGAPS--NGSGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFC
   .  ||. ||.|. ....| .|.|.| ||   .. .  .|||. . |..||    .   . | ...||..|.|  .|. . |.||||.||.|||| ..
gvtt..fGdvsvvllsvsereGfikrelevt...kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

ALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLN
..   . ..| |. |.|...||.|| .| ..||  .|| |.| |.|..  | .
tidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2391-2641 2e-66 218.9 In-house 38-284 (287) alignment 
Range on Protein: 2391-2641
Range on HMM: 38-284/287.0
SVDVCLNPMNKLRNRYANIQCYDHSRVKLTpveDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPD
.| . . . || .||...|  .|  || |    .  .||||| || ||. ...||....|. .|. .||....| . ...|||....|. . .| ||||.
evthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe

TvgRSERFGPISVTFIKSTSHADYCIREFEIQTQD-EKTTRSIKQFHYTSWPDFG-VPRHPTPLIQFIHTVRRHHKYTdKRPMIIHCSAGVGRTGTFITI
.  .|  .|. ...... . .|.| .|..|.. .. .......||...|.|.. | |... | |... . .. ..| . . ....|||..|||...|. .
e..ksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg.ntsivvhCsdtvGrsamfcaa

DSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTD
.  ......|  .. .| ....|  . ..||| .|. || |...| |....| 
attinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_PTPN23_pd Subfamily PTPN23 2394-2633 4.2e-66 217.7 In-house 37-278 (288) alignment 
Range on Protein: 2394-2633
Range on HMM: 37-278/288.0
VCLNPMNKLRNRYANIQCYDHSRVKLTpveDSPHDYINANFIHGYNR-DNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTV
...  ..  .||. .|  |||.||||    .|  ||||| |...      .|||||.||. |..|||.||..  |...|||.. .|. . |. .|||   
iaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk

GRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTD---KRPMIIHCSAGVGRTGTFITID
|....||..|||  . ..   .  |.....|.|.....|..  ..||||..|||  |  |.||.. |. ... .    | |...||||||||||.|  . 
getvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvy

SEMQRADQEREL-NPYQFVRQMRENRNHMVQTEAQFVFIHDALVE
. ..  ...  | .  | |...||.| .|||...|. |  .| .|
aavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2399-2636 4.4e-66 217.6 In-house 19-265 (270) alignment 
Range on Protein: 2399-2636
Range on HMM: 19-265/270.0
MNKLRNRYANIQCYDHSRVKLTPVED-SPHDYINANFIHGYN-RDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGR--
 .|  ||||.|    ..||.| ..|. |   |||||...|.. .....||..|||| |. .||||.|. .....||.|.|.|| | || .|||  ...  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

SERFGPISVTFIKSTSHADYCIREFEIQtqDEKTTRSIKQFHYTSWPDFGVPRHPT------PLIQFIHTVRRHHKYTDKR-PMIIHCSAGVGRTGTFIT
. ..| |.|. .... .  | ... ...  .. ..| .  |.|..||| ||||..        |.. ...|||..| .||  |...|||||||||||.|.
kledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILN
.|  ..  ........ . ....|..|  .||.  |. |.. |.||  .
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2684-2930 1.2e-65 216.6 In-house 37-276 (515) alignment 
Range on Protein: 2684-2930
Range on HMM: 37-276/515.0
SARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYK
 |... |  ||| .| |||| .||||  |  .  |||.|||.| .... ..|||.|.|.. ...|||... ...|. |.|... .| .. .  ..||| |
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdk.ikcgkyWPdk

RGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTprDTppeTRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTGnKPILVHCSAGIGRTGAFCAL
 |. . ||| .| |  ..   . | |.|.|.    |    .| |  | || ||  |.| . | .. || .|.  ..|    |...|||||.|||| ....
pgdsvkfGsikvelvsleactggikrkltvlkg..dd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisi

SIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
   . ..|  ..|...|.|. .| .| ..||  .|| ||| |.|.. 
dsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2690-2933 2e-63 209.1 In-house 28-271 (274) alignment 
Range on Protein: 2690-2933
Range on HMM: 28-271/274.0
NKDKNRLHNALPYDHNRVKLT-KIPGEIGSDYINASFIDGYKA-KNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYKRGEE
.. ||| .. || .. || |. . . .  |.|||| .| ||.  ...|.|.| |  ||..|||.|| ...|.|||||.. .|...    |.|.| ... |
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeane.qkCavyfPdaedye

L--AFGSASVTLQLTNHQEDYIHRQLRVTYTPRdtppeTRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTGNK--PILVHCSAGIGRTGAFCAL
.   .|  ... . .....||  |.| . |. |     .| |.|. .|.||   .| . . ..||...|.. .... .|  |..|||||||||||.| | 
iserygdveikvekiverndysvrklvlkyler.....ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

SIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESL
|||. ... |..|.. .|| .|| .|  |||. .|| .|.||.  |.. |
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2399-2633 9.8e-63 206.5 In-house 6-238 (239) alignment 
Range on Protein: 2399-2633
Range on HMM: 6-238/239.0
MNKLRNRYANIQCYDHSRVKLTPVEDSPH-DYINANFIHGYNRD-NEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVgrsE
.|| .||||||  |||||| |  . . || |||||.... |.   . .||||| .  . ||||||.|.     .|||| | |  . || |||||.     
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...s

RFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHhKYTDKRPMIIHCSAGVGRTGTFITIDSEMQRAD
..  . ||. |.   ||| || | .    .   | . |.|.| ||| |||.. | .. . . . .       || .|||||||||||.|. ||. ...| 
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtgaflvidamlrqak

QERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVE
... .. ...|. .||.| |||||  |.|||| |..|
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2399-2633 1.4e-62 206.0 In-house 7-239 (239) alignment 
Range on Protein: 2399-2633
Range on HMM: 7-239/239.0
MNKLRNRYANIQCYDHSRVKLTPVEDSPH-DYINANFIHGYNRD-NEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVgrsE
.|| .||||||  |||||| |  . . || |||||.... |.   . .||||| .  . ||||||.|.     .|||| | |  . || |||||.     
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...s

RFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHhKYTDKRPMIIHCSAGVGRTGTFITIDSEMQRAD
..  . ||. |.   ||| || | .    .   | . |.|.| ||| |||.. | .. . . . .       || .|||||||||||.|. ||. ...| 
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtgaflvidamlrqak

QERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVE
... .. ...|. .||.| |||||  |.|||| |..|
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2399-2633 1.6e-62 205.8 In-house 2-237 (237) alignment 
Range on Protein: 2399-2633
Range on HMM: 2-237/237.0
MNKLRNRYANIQCYDHSRVKLTPVEdSPHDYINANFIHGYNR-DNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTvGRSER
 ||..|||.||..|||||| |     |  |||||....|..   ...||.||||  .  |||.|||.     .|||| | |. ..|| .|||.|  . . 
enkiknrygnivaydhsrvvlkgag.sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaa

FGPISVTFIKSTSHADYCIREFEIQTQD-EKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHK-YTDKRPMIIHCSAGVGRTGTFITIDSEMQRA
.| ..|.. |    .|| .| . ....   |  | |.|...||||| |||.. . |..| . .  . .  ..  | |||||||||||| |. ||. ...|
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

DQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVE
 ... .. |..|  . |.| ...||. |.||||....|
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_CG7180_pd Subfamily CG7180 2679-2929 6.4e-61 200.6 In-house 31-289 (296) alignment 
Range on Protein: 2679-2929
Range on HMM: 31-289/296.0
FDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfvMSAQ
 .|   . .  |..|||  . .|||.||| |.|. ||  ||||||...|..  |. ||  .|||..|...||... ....| .|.|..| . ..  |  .
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak..myps

YWPYKRgeELAFGSASVTLQLTNHQEDYIHRQLRVTYT-------PRDTPPETRVVHHFSFTSWPR-SGAPSNGSGMIDLIDQVQKRQQQT----GNKPI
||| |   .  .|   | .  ...  .   |....| .        ..   |||.|..| .| |.     |.  ...|.|. .|.. ....     ..|.
ywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPv

LVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDY
.|..| | .|.|...|. ...| |. |. |.... || || .| ..|.| ..| .||  .|..
vvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2684-2937 2.1e-60 198.9 In-house 34-300 (301) alignment 
Range on Protein: 2684-2937
Range on HMM: 34-300/301.0
SARNDANKDKNRLHNALPYDHNRVKLTKIPG--EIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQFVmSAQYWP
   ...||  || .|  .||.||. |.. |       .|||||.||||. |. .||||.| ..|| |||..| ..... |||..|..|. .   . ||||
vglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtksk.ceqywp

YKRGEELAFGSASVTLQLTNHQEDYIHRQLRVT--------YTPRDTPP----ETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTGNKPILVH
  . |.  ||  .|||. ..   |.. ||| |.        |. |        ... |  .  |.||  |   .   ..  ||.| .|||. |  |..||
nseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVH

CSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNSYA
||....|.| .|..||..| .| | .|......| .| ..  .|. |.||..|| .|  | .  . ||
CSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstya
subfamily_PTPN3_pd Subfamily PTPN3 2682-2929 2.6e-60 198.7 In-house 33-274 (280) alignment 
Range on Protein: 2682-2929
Range on HMM: 33-274/280.0
FYSARNDANKDKNRLHNALPYDHNRVKLTKIPgeIgsDYINASFI----DGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSA
   ||  .| .||| .. ||||. ||||.. .     |||||...    .. .. | |||.| | ..| .|||.|. ||..|.||||... |. . |   
isaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr.vkCh

QYWPYkRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTprdTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQqQTGNKPILVHCSAGIGRT
||||   ..|| .|. ||... ..... |. |.| .. .   .  | | .... ...|| .| |.. . .......|.| . .. ..|..||||||||||
qyWPe.tedeleygefsvkcekedetksyvlrelvlkdk...etkeerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhCsaGigrt

GAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDY
| . .| .|.  .  .. |.. .||...| ||| .||. .|| |.  |||  
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPN13_pd Subfamily PTPN13 2666-2930 4e-60 198.4 In-house 14-269 (273) alignment 
Range on Protein: 2666-2930
Range on HMM: 14-269/273.0
SHEFSRLQSERAHfDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGeigsdYINASFIDGYKAK--NCYIAAQAPKDNTLNDFWKMICEQQVSVIVM
..||  |.  ..  |.  ......|||||| .| ||||. |||| .  |     |||||.|     |    |||.| |  .| .|||.|. ||...||.|
aeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LANTEEKEQfVMSAQYWPYKRGEELAFGS-ASVTLQLTNHQEDYIHRQLRVTYTprdTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQqtG
...  ||.. |   .||| .....|   .   |.|  .......  |.| |. .      |.| | |. |..||  | ||.   .. .. .|.. |.   
vtlekekgk.vkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds...esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..d

NKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
. ||.|||||||||.|.. .. .... .. .. ... .||..|| ||  .||  |||.|.|.|||.  
agPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2672-2933 8.2e-60 197.1 In-house 4-267 (270) alignment 
Range on Protein: 2672-2933
Range on HMM: 4-267/270.0
LQSERAHFDDFYSArnDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKN-CYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEK
|. |... .|. .|    .|  || .. ||  . ||.| ..  .  . |||| .. |.. ..  ||||..|...||..||.|| |..|. |||... |||
ldkeetsesdlpea..argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEk

EQfVMSAQYWPYKRGE--ELAFGSASVTLQLTNHQEDYIHRQLRVTytprDTPPETRVVhHFSFTSWPRSGAPSNGS------GMIDLIDQVQKRQQQTG
 .    ..||| ...|  .|..|  .|. . ....| || ..||..    ..  | |.| || ...||  |.|..         .. .. .|.. .... 
gr.kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle....ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeld

N-KPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESL
. .|.|||||||.|||| . || ||.. .. .. |.. .|...|| .|  .||  .|| |.|.|.. ||| .
kaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN14_pd Subfamily PTPN14 2666-2930 1.9e-58 192.8 In-house 26-296 (300) alignment 
Range on Protein: 2666-2930
Range on HMM: 26-296/300.0
SHEFSRLQSERAHfDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEiGSDYINASFIDGY--KAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVM
  |. |.. .|..  ....|... |..||| .. |||..|||.|.    .  ..||||| |      ..  ||.||.| ..|..|||.|. ||.|..|||
fteyeripkkred.allstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LANTEEKEQfVMSAQYWPYK--RGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDtppETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQ---
|...||. .   | .|.| .  . ... ||   || ..... . .| ..|.. . |     | | |.|. .| ||  | |.. .|... ...||  .   
lteeeedgk.eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk...eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

QQT-----GNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
...      . |.|||||||.||||      . |. .. .. ..| .....||.|| ..||.| || |.|.... | 
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2686-2928 6.7e-58 191.2 In-house 44-277 (439) alignment 
Range on Protein: 2686-2928
Range on HMM: 44-277/439.0
RNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfvmsaqYWPYKrg
 .. .. ||| ..  ..|| || | .|||   | |||| .|.||  .. |||.|.||..| .|||... |.... ||||.|  |  .      ||| .  
aqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk......ywpsd..

EELAFGSASVTLQLTNHQEDYIHRQLRVtYTPRDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALSI
.|  .|  .|  .      .|. | ..| .  |||    | | .| ...||    |.. | ..|..  ..  ...    |..||||||.||||.  || |
aevcygdiavrvdrnielpnyvirgfkv.fnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdi

AIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILD
|.|..|.|  |.|  ||| || || .|||.| |||||| |.|.
aleqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2400-2636 7.9e-58 190.5 In-house 38-278 (287) alignment 
Range on Protein: 2400-2636
Range on HMM: 38-278/287.0
NKLRNRYANIQCYDHSRVKLTPVEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTvGRSERFG
.  .||||..  .|..|| |.   .   ||||||.. .|..|..|||.|||.. |..||||.|.. .| .|...|   |. | || .|||.   .  | |
avkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvG

PISVTFIKSTS-HADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHK----YTDKRPMIIHCSAGVGRTGTFITIDSEMQR
  ||. .. .  . .|..| . .   . . .| .||... |||| ...     ||.|.  |..| .     ..  |...|...|.||.|.....   ..|
GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr

ADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILN
  .  .... . | ..|| |. .||.  |. .. .|||   .
ledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2684-2931 1.2e-57 190.0 In-house 27-267 (283) alignment 
Range on Protein: 2684-2931
Range on HMM: 27-267/283.0
SARNDANKDKNRLHNALPYDHNRVKLTKIPGeigsDYINASFID---GYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYW
 | .| || ||| .. .|.| .||.|   .     |||||.||     || .. ||.||.| |.|  |||||. ..... ||||..  | .. .  .|||
iasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlr.ikCsqyW

PyKRGEElAFGSASVTLQLTNHQEDYIHRQLRVTYTprDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDlIDQVQKRQQQTGNKPILVHCSAGIGRTGAF
| ||| |  .|   |||.    .. .| ..| . .    .  .| .. |. .  |   |  .    ..  ...|.  |..  . ||.||||.|||||..|
P.krGse.dyGeftvtlrkettsnsfiikelllrvn..ssakstlllahyqvidWleygeqaiinslvk.fnkvislqteskkgPivvhCstgiGrtavf

CALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAE
.|.| ... .. | .|.....|| .| ||  .||.|||| ... ..|. | 
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqal
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2394-2668 1.3e-57 190.0 In-house 39-270 (392) alignment 
Range on Protein: 2394-2668
Range on HMM: 39-270/392.0
VCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSPH-DYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMrvkctqywpdtv
|. ...|. .||| ||  || .||||  ..|.|. ||.|| .|.... .. .||.||| . .. ||||||.. .  |..|.|.|.|              
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

grserfgpisvtfikstshadycirefeiqtqDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHH-KYTdkRPMIIHCSAGVGRTGTFITIDSE
                                  . .|.. |||.| ||| .||.| . |..||. |. .. .||  .|.||||||||||||  |.||| 
................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt..hpliihcsagvgrtgvvisidsv

MQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQLEARMAELEIEDD-EGETGYSHE
. .| . | .. ..|| ..|..| .||||. |. ||. |..| |   .| | . ..  ....|.   | .. .  . |
vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdvrskqlke
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2387-2647 1.4e-57 189.8 In-house 20-278 (283) alignment 
Range on Protein: 2387-2647
Range on HMM: 20-278/283.0
SPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDsphDYINANFIH---GYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVK
 |. ..|.  .  ||  ||. .|  .|  ||.| .      ||||| ||     |..|...|..|.|| .|. |||.||.| .  ..||||.||| .|.|
vpdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrik

CTQYWPDTvGrSERFGPISVTFIKSTSHADYCIREFEIQTQ-DEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFiHTVRRHHKYTDKRPMIIHCSAGVGRT
|.||||   | || .|.  ||  | |..  . |.|. ....   |.|  .  . .  | ..|       |..|   |.   .   | |...|||.|.|||
CsqyWPkr.G.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvislqteskkgPivvhCstgiGrt

GTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQL
..||.. . .. |  |  .. .. |. |||.|  .|||  |. ..|.. .|    | |.|   .|
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2391-2640 4.4e-57 188.1 In-house 31-298 (301) alignment 
Range on Protein: 2391-2640
Range on HMM: 31-298/301.0
SVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVED---SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQY
| .| |. .||  ||. ||. ||. |. |.| ..   . ..||||..|.||.. ..|||.|||.  |. ||||..|..   ..||.|||.|... ||.||
sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqy

WPDTVGRSERFGPISVTFIKSTSHADYCIREFEIQTQD---------------EKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKRPMI
||..  .||.|||..||..... . |. ||.. .. ||               .|..... |.. |.||. || | |   .| |. |    .  .. |..
wpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvv

IHCSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKT
.|||..|.|.|......  .  .  |   . .| .. .| ..  .|.|  |...|.|.. . |.  .|
VHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_CG7180_pd Subfamily CG7180 2400-2637 8.6e-57 187.0 In-house 42-292 (296) alignment 
Range on Protein: 2400-2637
Range on HMM: 42-292/296.0
NKLRNRYANIQCYDHSRVKLTPVE-DSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRvKCTQYWPDTVgrSERF
|. .||. ..  ||. || |. .. ..  ||||| .. .. ...|.| |..|  .|...|||.|.| |. .||.||.  . .. .. .||| .    |..
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqy

GPISVTFIKSTSHADYCIREFEIQTQ----------DEKTTRSIKQFHYTSWPD-FGVPRHPTPLIQFIHTVRRHHKYT----DKRPMIIHCSAGVGRTG
|.| |  ... . |.  ||.| .. .           .  || .|.|..| |.    ||   . ||.... ||   . .    .. |.....| |..|.|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

TFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNT
 ...||  .. ...| |.. ...|...|..|...|..  .. .| | | | . .
vylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2383-2647 2.9e-56 185.8 In-house 29-291 (439) alignment 
Range on Protein: 2383-2647
Range on HMM: 29-291/439.0
INRSSPNPSVDVCL--NPMNKLRNRYANIQCYDHSRVKLTPVEDSPH-DYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEK
||  ||. ... .|  .  .. .||| ..  .||.|| |  .   ||  |||||.|.||  |. .||||||  .|  ||||.|..  . |.|||||| | 
instspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlves

MRvkctqYWPDTvgRSERFGPISVTFIKSTSHADYCIREFEIQTQDEK--TTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKRPMIIHCSA
..     |||        .| |.|   .     .|.|| | .  . ..    |.. ||||..|||  || . . ...|....       .  |...||||
yk.....ywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsa

GVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKTDIGIEQL
||||||| |..|  ...   | ...    |. .|..|..|||. .|.|||..|..| .  |.. . |...
gvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_PTPN14_pd Subfamily PTPN14 2377-2637 2.1e-55 182.8 In-house 28-298 (300) alignment 
Range on Protein: 2377-2637
Range on HMM: 28-298/300.0
EFGKIDINRSspNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSPHDYINANFIHGY--NRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLT
|. .|  .|   .  .... .| |. .||. ..  |...||.|.| ... ..||||  |.     .. ..|..||||. |. |||.|||. .   .||||
eyeripkkre..dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NLQEKMRVKCTQYWPDTV--GRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIH---TVRRHHKYTD--
. .|. . |. .|.|..    .. .||   ||   |..   .  . ....    |  |..  . || ||| |||. ... .....    |||. . .   
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

---KRPMIIHCSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNT
   | |...||||||||||  |. |  ..  ....|..  . ....|| | ..||| ||. |....|.. |. 
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
0051429 (Phosphotyrosine protein) phosphatases II 2427-2636 1.3e-53 177.7 In-house 4-226 (272) alignment 
Range on Protein: 2427-2636
Range on HMM: 4-226/272.0
HDYINANFIHGYNR---DNEFIATQGPLPDTIGDFWRMvWDYESPTVVMLTNLQEKMRVKCTQYWP----------DTVGRSERFGPISVTFIKSTSHAD
 .||||... ||.|   .. .....|||| |. ||||. ...   |.|.|... |. |.|| .|||          |..  . ..| ..||... . . |
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YCIREFEIQTQ-DEKTTRSIKQFHYTSWPDFGVPRHPtpLIQFIHTVRRhhkytdKRPMIIHCSAGVGRTGTFITIDSEMQRADQERELN--------PY
| .||...  . . ...| . ..|||.|||.|||...  |..... ...      ..|...|||||..||||.. ..  ... . |  ..        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QFVRQMRENRNHMVQTEAQFVFIHDALVEILN
..|...|. | ..||||.|..|...||.|.|.
eaveelraqrpgavqteeqylflyeallellr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2664-2931 5.8e-53 174.5 In-house 11-278 (287) alignment 
Range on Protein: 2664-2931
Range on HMM: 11-278/287.0
GYSHEFSRLQSE-RAHFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKiPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIV
   .|. .|. . ..    | .| . |.  |||  . ||.|..|| |..  || ||||||| .. .|. .. .||||.|   |..|||... |.......
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

MLANTEEkEQFVMSAQYWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTprDTpPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQV----QKRQ
...   | |      .||| ..   .  | . | |. .. . .|  | ||.     .|  |.|||. . . |||  ...    |.| .. .|    . ..
tmtreve.earlkcykywPerevPmrvGGysvvlldydikePeygvralrlidl..et.rearvvkqldllswPdkvlaPtavglirfvldvkqhielar

QQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAE
. ..  |..||...||||.| . |. . ..| .    |.. ..| .|| .|| .||   |. ..| |.  | .
dasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_PTPRN_pd Subfamily PTPRN 2393-2636 1.9e-52 172.8 In-house 49-293 (297) alignment 
Range on Protein: 2393-2636
Range on HMM: 49-293/297.0
DVCLNPMNKLRNRYANIQCYDHSRVKLTPV-EDSPHDYINANFIHGY-NRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPD
.|. .. |  .||....  ||||||||.   ... .||||| .|     |   .|||||||..|. |||.|||.  .  .|.||.|.|.   .|..||||
evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd

TVgrSERFGPISVTFIKSTS-HADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYtDKRPMIIHCSAGVGRTGTFITID
.   || ..   | ..       || .| | ..  . . ||.. |||. |||. |||  . .|..|   | . ..     |...|||.|.||||..| ||
eG..sevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilid

SEMQRADQ-ERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILN
  ..|  .  .|..    .  .|..|...|.|..|| |.  |..| .|
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevn
0041856 (Phosphotyrosine protein) phosphatases II 2400-2640 8.8e-52 170.7 In-house 1-176 (182) alignment 
Range on Protein: 2400-2640
Range on HMM: 1-176/182.0
NKLRNRYANIQCYDHSRvkltpvedsPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTnlqekmrvkCTQYWPdtvgrserfg
|. .||| .| .|||||         . ||||||.. |. ....||||||||..|. ||.||....   |.|.||         . .|||          
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

pisvtfikstshadycirefeiqtqdEKTTRSIKQFHYTSWPDFGVPRhPTPLIQFIHTVRRhhkytDKRPMIIHCSAGVGRTGTFITIDSEMQRadqer
                          |. .| . |..|..|||.|||  .  |..||..|..     ...| ..|||||||||||.. ..  ...     
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

ELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGKT
...... |...|. |..||.|. |..|...|| |.|  .||
gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2690-2928 3.9e-50 165.3 In-house 3-237 (237) alignment 
Range on Protein: 2690-2928
Range on HMM: 3-237/237.0
NKDKNRLHNALPYDHNRVKLTKiPGEiGSDYINASFIDGYKA-KNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQFvMSAQYWPYKrGEEL
|| |||  |   |||.|| |   .|  |||||||....|.    . ||||| | ... .|||.|. ... ||||||.   |...     .|||    .  
nkiknrygnivaydhsrvvlkg.ags.gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnel.kchkywpst.dqpa

AFGSASVTLQLTNHQEDYIHRQLRVTYtpRDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQ-TGNKPILVHCSAGIGRTGAFCALSIAI
|.|  .|.|.  ..  ||  | | ...  | |  | |..| . |||||  | | . . .. .  .. .| .  .   | ..|||||.|||| |  .   .
aygvltvslkkkeefsdytvrslllsk..rltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

ERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILD
 . | ...|.||| |. .  .| ...|  ||||||...||.
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPRN_pd Subfamily PTPRN 2668-2928 2.1e-49 162.8 In-house 34-290 (297) alignment 
Range on Protein: 2668-2928
Range on HMM: 34-290/297.0
EFSRLQSERAHFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKA-KNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLAN
|.  | . .|.      |... | .||| ...|||||.||||..   .  |||||||.|      . .|||.|.|  .|. |||.|. || | |||.|..
ewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltr

TEEKEqFVMSAQYWPyKRGEELaFGSASVTLQlTN--HQEDYIHRQLrvtYTPRDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQtGNK
 ||..     ..||| . |.|. ..   | |  ..    .||. | .   |       ||| |  | | |||..|.|..   ....  .|.|  .     
leeeg.vkqckrywp.deGsev.yhiyevhlv.sehiwcddylvrsf...ylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rsc

PILVHCSAGIGRTGAFCALSIAIERV-KVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILD
||.||||.| ||||..... . ..|. |  . ..|   ..||| ||...|.  ||. |.. |. .
pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN1_pd Subfamily PTPN1 2681-2938 4e-49 161.9 In-house 23-279 (290) alignment 
Range on Protein: 2681-2938
Range on HMM: 23-279/290.0
DFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGeigsDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYW
.  .|....|...||  .  |||| |.|| .       ||||||...  .||  || .| |  || . ||.|. ||.   .||| .  |||| .  ||||
ptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeq.ikcaqyw

PYKRG-EELAFG--SASVTLQLTNHQEDYIHRQLRVTYtprDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQ-TGNKPILVHCSAGIGR
| .   .|| .   . .|.|  ..... |. |.|...     .  |||.. || .|.||  | |.  . ..... .|..     .   | ..||||||||
Pqgeeekellledtklkvkliseerksyytvrllelen...lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGr

TGAFCALS---IAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNSYAN
.|.|| .    . ||. .    |.| . . .|| .|  ..|  ||  | | |||. |  ... . 
sGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdss
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2398-2634 7e-49 161.2 In-house 31-258 (267) alignment 
Range on Protein: 2398-2634
Range on HMM: 31-258/267.0
PMNKLRNRYANIQCYDHSRVKLTpveDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKmrvKCTQYWPDTVGRSER
  |. |||. .   ||..|| |    .. ..|||| ...||.. | ||.||.||  ||.||. .. |.. |..|.||.  .    .  ..||  .|....
eknqernrlddnlpyddtrvilr...tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakk

FGPISVTFIKSTSHADYCIREFEIQTQDEKtTRSIKQFHYTSWPdfgVPRHPTPLIQFIHT-VRRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEMQRAD
.  ..| .       || |  .|.. ..|  .. .  ..|  |    .     | .. .   . . .     ||....||.||||.|||..||| ..|| 
yqdltvehslekeendyqiitlelkfknes.ahnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerak

QERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEI
.|  .. ..|.|..|. |  .|.|  ....||. |.| 
tegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2685-2932 9.2e-49 160.8 In-house 28-261 (267) alignment 
Range on Protein: 2685-2932
Range on HMM: 28-261/267.0
ARNDANKDKNRLHNALPYDHNRVKLTKIPGEigsdYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfvmsAQYWPYKR
     |...||| ..||||..|| | .   |    |||||...||| || .|. | | .||  ||...| .|.|.|||.| .. . .      ..|| | 
siaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdni....rlfwPPkm

GEELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDtppeTRVVHHFSFTSWPRSGapSNGSGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALS
|.   .   .|   | . ..||    | . .        .. |  . .  |       |   .  |.  . | | . ||.|..|.||.|.||.|.|  . 
gqakkyqdltvehslekeendyqiitlelkfknes....ahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvid

IAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAES
  .||.| | ...|.. ....| ||  .|. ...|..|.. . .||| 
sqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg
0051429 (Phosphotyrosine protein) phosphatases II 2718-2933 2.3e-48 160.5 In-house 4-228 (272) alignment 
Range on Protein: 2718-2933
Range on HMM: 4-228/272.0
SDYINASFIDGYKA---KNCYIAAQAPKDNTLNDFWKMiCEQQVSVIVMLANTEEKEQfVMSAQYWP----------YKRGEELAFGSASVTLQLTNHQE
|.||||....||     .. ......| ..| .|||.. .|.....||.| ..||... .   .|||              ..  .|  .|||. . ...
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgr.lkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYIHRQLRVTYTPRDTPPetRVVHHFSFTSWPRSGAPSNGsgMIDLIDQVQKrqqqtgNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVN-------
|||.| |..|..   . .  | |.|. .|.||  |.|..   ...|......      ..|.|||||||..||| ..|| . ...|  | ||.       
dyilrellltlllsagea..revmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESL
 ....|..|| ||...||. .||.|.|.|.|....||
yleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2402-2634 3e-48 158.9 In-house 58-282 (290) alignment 
Range on Protein: 2402-2634
Range on HMM: 58-282/290.0
LRNRYANIQCYDHSRVKLTpvEDSPHDYINANFIHGYNrdNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERFGPI
 .||| .. | | .|| |   .  . ||. ||...| .    || |||.| ||. |.|||| . .  ..||| .| |. . || ||.|.. |.   || |
kknrykdvvcndktrvilk..dGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGei

SVTFIKSTSH-ADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHhkytdKRPMIIHCSAGVGRTGTFITIDSEMQRADQERE
.|.  ..... |.   . . .. .|.     .| ..  ||||  |.     |.. ....|.        |...|||||.||||||..|.  .|   . .|
tvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqilldGke

LNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEI
|.. . || .|. |   || . |.. . ..|...
ldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2666-2928 4.6e-48 158.6 In-house 23-234 (392) alignment 
Range on Protein: 2666-2928
Range on HMM: 23-234/392.0
SHEFSRLQSERAHfdDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLA
..||  | .  ..  .  .|... |. ||| .| |||| .||||  |     |||.|||.|........|||.|.|.  .|.|||.|. ...|. |.|..
feefhdlpgpdiy..pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

NTEEKEqfvmsaqywpykrgeelafgsasvtlqltnhqedyihrqlrvtytprdTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTgNKP
. .| .                                                   ..| |  | || || .. |   | .. .| .|.    |   .|
klkegd................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy.thp

ILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILD
...|||||.||||   ..   . . |  ..|...|.|  .| .| .|||  .|| ||| |.|.
liihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
0036282 (Phosphotyrosine protein) phosphatases II 2427-2629 1.2e-47 157.2 In-house 2-164 (174) alignment 
Range on Protein: 2427-2629
Range on HMM: 2-164/174.0
HDYINANFIHGYNRDNEFIATQGPLPdtigdFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDtvgrserfgpisvtfikstshadycirefeiqtQDE
.|||||...... . ...||.||||.     ||.|.... . |||||....|. ..|| .|||.                                   |
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

KTTRSIKQFHYTSWPDFGVPRHPTpLIQFIHTVRRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEMQRADqERELNPYQFVRQMRENRNHMVQTEAQFVF
  .|.. |..|. |||.|||  .. |..|.  |.....  ...|...|||||||||||.. ..  ...   |.  . ...||..|  | .||||. |. |
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IHD
...
lyy
0041856 (Phosphotyrosine protein) phosphatases II 2690-2930 3.1e-47 155.8 In-house 1-171 (182) alignment 
Range on Protein: 2690-2930
Range on HMM: 1-171/182.0
NKDKNRLHNALPYDHNRvkltkipgeiGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLAnteekeqfvmSAQYWPykrgeela
|.||||  . |||||.|          ..|||||....|.   . .||.|.| ..|..||..|. |.....||.|.          . .|||        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..........eelywp........

fgsasvtlqltnhqedyihrqlrvtytprdtPPETRVVHHFSFTSWPRSGAPSnGSGMIDLIDQVQKrqqqtGNKPILVHCSAGIGRTGAFCALSIAIER
                                 ..| .... ...||  |.|.  . ..|.|..|..      ..|.|||||||.||||...|. . ...
...............................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl

vkveHiVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
    . |.....||..| .| .||....||.|...|.|.. 
....g.vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2685-2928 3.2e-47 155.7 In-house 2-238 (239) alignment 
Range on Protein: 2685-2928
Range on HMM: 2-238/239.0
ARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKA-KNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYK
|..  || |||  | . |||.|| | |.  .  |||||||..  |    ..|||.|     .  |||.|. ...  |||||.   |  .     ||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk.kkchqywpds

RGEelaFGSASVTLQLTNHQEDYIHRQLRVTYTPRdTppETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKrQQQTGNKPILVHCSAGIGRTGAFCAL
  .   .    |||. |.   ||| | . ..   . |  | | |... || ||  | |   . .. |  .. | .   | .| ..|||||.||||||  .
tsk...ycnlrvtlrktevfadyiirtfvmsqvgq.t..eeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvi

SIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILD
   . . | .. |.|.| || .| .| ||||  .|||||. |.|.
damlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2685-2927 3.5e-47 155.6 In-house 3-238 (239) alignment 
Range on Protein: 2685-2927
Range on HMM: 3-238/239.0
ARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKA-KNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYK
|..  || |||  | . |||.|| | |.  .  |||||||..  |    ..|||.|     .  |||.|. ...  |||||.   |  .     ||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk.kkchqywpds

RGEelaFGSASVTLQLTNHQEDYIHRQLRVTYTPRdTppETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKrQQQTGNKPILVHCSAGIGRTGAFCAL
  .   .    |||. |.   ||| | . ..   . |  | | |... || ||  | |   . .. |  .. | .   | .| ..|||||.||||||  .
tsk...ycnlrvtlrktevfadyiirtfvmsqvgq.t..eeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvi

SIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAIL
   . . | .. |.|.| || .| .| ||||  .|||||. |.|
damlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2398-2634 5.3e-46 152.0 In-house 39-276 (307) alignment 
Range on Protein: 2398-2634
Range on HMM: 39-276/307.0
PMNKLRNRYANIQCYDHSRVKLTpVEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSER
  |  .||| ...| |..|. .. ..    ||| ||..    . . ||..|||| .|. .|| |. . .  .|.|| .. |  ..|| ||||   |.   
santdknryqdvkcqdkgrivvk.fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

FGP----ISVTF--IKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRrhhkyTDKRPMIIHCSAGVGRTGTFITIDSE
||     |||.   .|  .  . .|   ... .  . .|.|... .. ||| |||.     | ....||      |. |...||||||||.|| ..|   
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr.....ydtnpvvvhcsaGvGrsGtivaislv

MQRADQEREL-NPYQFVRQMRENRNHMVQTEAQFVFIHDALVEI
...  .  .  .  ..|...|..|.. .|||||....|  |.| 
qdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2686-2930 5.2e-45 148.8 In-house 37-277 (307) alignment 
Range on Protein: 2686-2930
Range on HMM: 37-277/307.0
RNDANKDKNRLHNALPYDHNRVKLtKIPGeIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYKRG
  .|| |||| ..    |..|. . |..| . |||| | ..      . .|.|| |..||  .|| |. ...|  ..||... |  . .   |||| ..|
afsantdknryqdvkcqdkgrivv.kfdg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielak.ikceqywpleeg

EELAFGSASVTLQLTNHQEDYIH---RQLRVTYTPRDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQqqtgnKPILVHCSAGIGRTGAFCA
..|.||.|. |. ..|   . .      . ||    |   ..| ..|. .. ||  |.|    . |.|.. |.  .      |..||||||.||.|.  |
qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npvvvhcsaGvGrsGtiva

LSIAIER-VKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
.|.  .. .. .   .. ..|. ||.|| . .|.  ||....| .|.| 
islvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0049772 (Phosphotyrosine protein) phosphatases II 2388-2641 8.6e-45 149.2 In-house 34-286 (314) alignment 
Range on Protein: 2388-2641
Range on HMM: 34-286/314.0
PNPSVDVCLNPMNKLRNRYANIQCYDhSRVKLTPVEDSPHDYINANFIHGYnrdNEFIATQGPLPDTIGDF----------WRMV--WDYESPTVVM---
|. .. |.  ..|. .||| .|...| .||.|  .. | .|||||....|.   . ||||||||. |. ||          ||||  .|. . ..||   
peltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LTNLQEKMRVKCTQYWPDTVgrserfgpisvtfikstshadycirefEIQTQDEKTTRSIKQFHYTSWPDFGVPrHPTPLIQ
                  |..| ...   . .....                             |... .|. .| . ..... .||...|  .  . .
evladelsrLdaAlgKtpllildgngneptaadlellk...........................eelydpelferlgikylripvpDgsap.lledfde

FIHTVRRHhkyTDKRPMIIHCSAGVGRTGTFITIDSEMQRAdqerELNPYQFVRQMRENRN-----HMVQTEAQFVFIHDALVEILNTGKTD
|.. ....    ...| ..||.||.||||||....  | .      ... . ....|. |      .....  |..||..|| | |.. |. 
flefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
subfamily_ptpA1_pd Subfamily ptpA1 2400-2596 3.1e-44 146.4 In-house 47-257 (418) alignment 
Range on Protein: 2400-2596
Range on HMM: 47-257/418.0
NKLRNRYANIQCYDHSRVKLTPVEDS-PHDYINANFIHGYNrDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGR----
|  .|||.||   .|.||.|  ..|    ||||||.| |    ..||.||||||.|| |||||||.     .|||.   |. |.|| .|||. .|     
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

-----SERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHK----YTD-KRPMIIHCSAGVGRTGT
      | ||  || ...     .  |   .|.   |  || | |..|  |||. .| |  |. |..|..  ...     .| . |.|.|||||||||||
iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgt

FITIDSEMQRAD
| |    |.. |
fctavimmkkld
0043147 (Phosphotyrosine protein) phosphatases II 2425-2628 3.1e-44 146.0 In-house 3-154 (172) alignment 
Range on Protein: 2425-2628
Range on HMM: 3-154/172.0
SPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLqekmrvkctqywpdtvgrserfgpisvtfikstshadycirefeiQTQ
...|||||.....|   ..||||||||. |. |||||....   ..|.||.|                                             .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lyd

DEKTTRSIKQFHYTSWPDFGVPrHPTPLIQFIHTVRRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEMqradqeRELNPYQFVRQMRENRNHMVQTEAQF
 |. .|.. |..|..|||.||| ..  |..|.. .....   .. |...|||||||||||.. ..  .      . |.... |...|| |...||.. | 
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

VFIH
 |..
rfly
0046846 (Phosphotyrosine protein) phosphatases II 2422-2634 2.7e-43 143.1 In-house 7-172 (176) alignment 
Range on Protein: 2422-2634
Range on HMM: 7-172/176.0
VEDSPHDYINANFIHGYnrdnEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSErfgpisvtfikstshadycirefei
..| . ||||||.| |.     .||||||||.|. ||..|....   .||.||...|. |.||..|||.  . .                          
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

qtqdekttrsikQFHYTSWPDFGVPRHpTPLIQFIHTVRRHHKYTdkRPMIIHCSAGVGRTGTFITIDsemqRADQERELNPYQFVRQMRENRN-HMVQT
            |.... |||.||| . . |....  .|.. |    .| ..|||||.|||||.. ..        |. |.... ....|| |  ..|||
............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

EAQFVFIHDALVEI
..|  |..... ..
peQyrflyefelll
0049772 (Phosphotyrosine protein) phosphatases II 2686-2936 1e-42 142.3 In-house 42-286 (314) alignment 
Range on Protein: 2686-2936
Range on HMM: 42-286/314.0
RNDANKDKNRLHNALPYDhNRVKLTKIPGEiGSDYINASFIDGYkakNCYIAAQAPKDNTLNDF----------WKMI--CEQQVSVIVM----------
.  .|.|||| .. ||.| |||.| . |.. ||||||||..||.   . .||.|.|...|..||          |.|.   ...| .|||          
dlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LANTEEKEqfvmsaQYWPYKRGEELAfgsasvtlqltnhqedyihrqlRVTYTPRDTppETRVVHHFSFtSWPRSGAPsNGSGMIDLID
           | .  ..        ... .. |.|                       ...| | .   | ...... .  .|  .||   . . ....
srLdaAlgKtpllildgng......neptaadlellk......................eelydpelf..erlgikylri.pvpDgsap.lledfdefle

QVQKRqqqTGNKPILVHCSAGIGRTGAFCALSIAIERVKvehiVNIYNIVKHLRTQRA-----HMVQNLDQYVFIYRAILDYAESLNSY
 ...      ..|.||||.||.|||| |... . . . .    |..  .....| .|      .....|.||.||..|.|.| . | ..
fieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
0036282 (Phosphotyrosine protein) phosphatases II 2717-2923 1.1e-42 141.0 In-house 1-163 (174) alignment 
Range on Protein: 2717-2923
Range on HMM: 1-163/174.0
GSDYINASFIDGYKAKNCYIAAQAPKDntlndFWKMICEQQVSVIVMLANTEEkEQFVMSAQYWPYkrgeelafgsasvtlqltnhqedyihrqlrvtyt
||||||||..|..   . .|| |.| .     ||.|..|......||| . .|  . ..  .|||                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleeke.lglykcinywpe..................................

prDTPPETRVVHHFSFTSWPRSGAPSNGSgMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALSIAIERVKvEHIVNIYNIVKHLRTQRAHMVQNL
  .   ..| .... .. ||  |.|.    .......|.. ... ...|.|||||||.||||...|. . . . . |  |.....|. ||.|| .|||. 
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

DQYVFIY
.|| |.|
sQyrfly
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2391-2637 9.5e-42 138.0 In-house 36-273 (288) alignment 
Range on Protein: 2391-2637
Range on HMM: 36-273/288.0
SVDVCLNpmNKLRNRYANIQCYDHSRVKLTpveDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPD
..|. ..  |  |.|| |. . | .||||.   | |. ||.|| .   . .. .| .| ||  ||. .|.|. . .   .|||..| || . |  .|.| 
iidsfia..nptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs

TVGRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRS-IKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKytdkrPMIIHCSAGVGRTGTFITID
 .|.. |.| .     |. .  |  ..   .. . |  ..  .|. |.  |.| |||    . ..... .. ..|     |...|.|||||||||.| | 
klGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk.....PivvhssaGvGrtgtlilil

SEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNT
  .. .  .  |   ... ..||.| . .||| |....|  . | |  
ialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
0043147 (Phosphotyrosine protein) phosphatases II 2717-2923 1e-41 137.9 In-house 4-154 (172) alignment 
Range on Protein: 2717-2923
Range on HMM: 4-154/172.0
GSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTeekeqfvmsaqywpykrgeelafgsasvtlqltnhqedyihrqlrvtyt
||||||||..|.|   . .|| |.| .|||.|||.|. |.....||.| .                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

PRDTPPETRVVHHFSFTSWPRSGAPsNGSGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALSIAIervkveH-IvNIYNIVKHLRTQRAHMVQN
  |.....| . .. ...||  |.| . . ..............  ..|.|||||||.||||...|. . .      . . .....|...|..| ..|||
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqn

LDQYVFIY
 .|| |.|
psqyrfly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2677-2928 1.4e-41 137.3 In-house 20-293 (297) alignment 
Range on Protein: 2677-2928
Range on HMM: 20-293/297.0
AHFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGeiGSDYINASFID--GYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfV
|. ..| ||. ..   ||| .. | .| .|||| . .   ..||||| ..     .|.  || || | ..|..|||... ||.| ||||.|. .|  .  
argesfssakrnsslrknryrdilatddtrvkllrvit..erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr.d

MSAQYWPYKRGEELAFGSASVTlQLTNHQEDYIHRQL-RVTYTPRdtpPETRVVHHFSFTSWPRSGAPSNG-----------------SGMIDLID----
  | |||   .| |  |.  |   |..  ... . .|  ..   |    |.|||.|  | |||  | ||.                    |. |..    
kcapywpsvvqerlkagdvvve.flsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemfta

----QVQKRQ-QQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILD
    |..  . ..  | ..|||||||.||.|      . ..... ..| ..  |...|| ||| .|| |.|. ..| |.| 
mvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2401-2636 4.8e-41 135.5 In-house 49-288 (305) alignment 
Range on Protein: 2401-2636
Range on HMM: 49-288/305.0
KLRNRYANIQCYDHSRVKLTPveDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPD----TVGRSE
. .||| .. | |. |||| .    ||.|| ||..      . || || || .|  ||| | ..    .. || ||.||   ||..|..     ..  .|
agknrykdvgcldnnrvkleg..pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

RFGPISVTFIKS-----TSHADYCIREFEIQTQD-EKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRrhhkyTDKRPMIIHCSAGVGRTGTFITIDS
.   ||| |  |     ...|.  ..| ..  .   ...| ....|.  ||| |||   . ......  |     . | |...|||||.||||. . .. 
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.....pskgpivvhcsagigrtgsvvmley

EMQRADQERELNP-YQFVRQMRENRNHMVQTEAQFVFIHDALVEILN
 ...  . . ..   . ....||.||  .||.||..|.|. ... ..
ildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2399-2633 1.9e-40 133.4 In-house 54-287 (305) alignment 
Range on Protein: 2399-2633
Range on HMM: 54-287/305.0
MNKLRNRYANIQCYDHSRVKLTpvEDSPHDYINANFIHG-YNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSER
... .|||... | |.| |||   . || ||| ||..      .. ||..|||| .|| .|| || .     .||| .  |  ..||.|||| . |    
iaitknryqdvpcqdqsavkld..kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

FGpiSVTFIKSTSHADYCIREFEIQTQD------EKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRrhhkyTDKRPMIIHCSAGVGRTGTFITIDSE
.   |   ..  | .    |. |||          . . |......| ||| |||      .... ..|       | |...|||||.||||| ..|.  
lk..sgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair.....gskvpivvhcsagigrtgtivaieyi

MQRADQERELNPY-QFVRQMRENRNHMVQTEAQFVFIHDALVE
...  ....  |  ..|. .|..| . .|.. |..|||  ...
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0049260 (Phosphotyrosine protein) phosphatases II 2434-2629 3.4e-40 132.6 In-house 1-144 (152) alignment 
Range on Protein: 2434-2629
Range on HMM: 1-144/152.0
FIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWpdtvgrserfgpisvtfikstshadycirefeiqtqdekttrsik
||.||.. .||||||||.| |. |||||....   |.||||.|.|. ..|| ||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QFHYTSWPDFGVPRHPTPLIQFIHTVRRHhKYTDKRPMIIHCSAGVGRTGTFITIDSEMqradqeRELNPYQFVRQMRENRNHMVQTEAQFVFIHD
|.... |||.||| ..  |..... .... .  .. | ..|||||||||||.. ..  .      . ......|...|| |...|... |  |...
qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2389-2633 3.7e-39 129.1 In-house 23-267 (281) alignment 
Range on Protein: 2389-2633
Range on HMM: 23-267/281.0
NPSVDVC---LNPMNKLRNRYANIQCYDHSRVKLTP--VEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVK
.|  |.|    .|.|. .|||.|| | | |||.|     .    ||| ||.|.       .| ||||  .|  |||||.|. .. ..||| .. |  | |
dppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrek

CTQYWPDTVGRSERFGPISVTFIKSTSHADYCIREFEIqtQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHhkytdKRPMIIHCSAGVGRTG
|..|.|       .|  .||..  ||         ...    |  || | .. .  |||. ||     ... .. .| .       | .|||||||||.|
caeyfprnahcclqfdklsvsyedstvnkslvttrlnl..syegetrlithwlwkewpdwqvpessevmlkilrkirar.....stppvihcsagvgrsg

TFITIDSEMQRADQERELNP-YQFVRQMRE-NRNHMVQTEAQFVFIHDALVE
|.....  .|       |    | | ..|   |   |||  |...|   |..
tlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2669-2930 1.5e-38 127.2 In-house 36-289 (305) alignment 
Range on Protein: 2669-2930
Range on HMM: 36-289/305.0
FSRLQSERAHFDDFYSArnDANKDKNRLHNALPYDHNRVKLTKIPgeiGSDYINASFIDGYK-AKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANT
..| .  .. |.   ||  | .. ||| ..    |.. ||| | .    |||| | ..      .. .|.|| | |.|...|| |. ...|  ||||..|
ytrpdmtqvafnanqsa..diaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlckt

EEKEQFvMSAQYWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDT-PPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQkrqqqTGNKPI
 |  ..   |||||  .|| | . |  |  ...  .      ....|         ..  | |. .| ||  | |      ..|.  ..       . ||
velgkl.kcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair.....gskvpi

LVHCSAGIGRTGAFCALSIAIERVKVE-HIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
.|||||||||||.  |.   .|..  . .   . ..|| || |||. .||  ||.||.| .|.| 
vvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
0046846 (Phosphotyrosine protein) phosphatases II 2712-2930 3.2e-38 126.6 In-house 6-173 (176) alignment 
Range on Protein: 2712-2930
Range on HMM: 6-173/176.0
IPGEIGSDYINASFIDGYkaknCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQFVmSAQYWPYKRGEELafgsasvtlqltnhqedyihrql
.  . ..|||||..|.|.    ..|| |.|  .|| ||..|. |......|.| .  |....   ..|||. .....                       
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlk.cpnywpeleklgi.......................

rvtytprdtppetrvvhHFSFTSWPRSGAPSNgSGMIDLIDQVQKRQQQTgnKPILVHCSAGIGRTGAFCALSiaieRVKVEHIVNIYNIVKHLRTQRA-
                 .. .. ||  |.|.  . ...|..........   .|.||||||||||||...|.      .. |. ..........| ||  
.................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRpl

HMVQNLDQYVFIYRAILDYA
..||. .|| |.|...| . 
gavqtpeQyrflyefellll
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2666-2930 3.6e-37 122.6 In-house 14-269 (281) alignment 
Range on Protein: 2666-2930
Range on HMM: 14-269/281.0
SHEFSRLQSERAhfDDFYSAR-NDANKDKNRLHNALPYDHNRVKLTK-IPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVM
 .||| |  .     |. ..  .  |. |||  |    |  ||.|   .| .  .||| | .|     |  || .| || .|  |||.|| ... . |||
kqefsnlpgdpp..sdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

LANTEEKEQfVMSAQYWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTprdtpPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQqqtgn
|..  | ..    |.|.| .    | |   ||. . .  ..  .  .| ..|       |||.. |. .  ||    |     |. .. ... |      
lcqfletnr.ekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye.....getrlithwlwkewpdwqvpessevmlkilrkirars.....

KPILVHCSAGIGRTGAFCALSIAIERVKVEH-IVNIYNIVKHLR-TQRAHMVQNLDQYVFIYRAILDYA
 | ..|||||.||.|.. |. ||.. ..    . .| .|| ||| | ||  || |.||..|.. .||. 
tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2400-2634 7.8e-37 121.8 In-house 35-269 (285) alignment 
Range on Protein: 2400-2634
Range on HMM: 35-269/285.0
NKLRNRYANIQCYDHSRVKLTpveDSPHDYINANFIHGYNRDN-EFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERF
|   ||||...| . .|| |    .  .||| |....   .|.  .|.||||||.|. |||.|... .   |.||  | |    ||. |.|. .|   .|
npdlnryadvrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

GPISVTF--IKSTSHADYCIREFEIQTQDEKTTRSIKQFH--YTSWPDFGVPRHPTPLIQFIHTVRRHHkyTDKRPMIIHCSAGVGRTGTFITIDSEMQR
|   .|.   |  . |   .  . .   .. ..  .   |     |||   |    |.|.. . |..      ..|. .||||||||| ||. ||    |
gkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn..pkekpicvhcsagvgrtatfvgidyatir

ADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEI
  .. ...  . ||.||  | . ||.  ||.|..  |.| 
imenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2690-2929 1.1e-36 121.4 In-house 43-270 (288) alignment 
Range on Protein: 2690-2929
Range on HMM: 43-270/288.0
NKDKNRLHNALPYDHNRVKLTkipgEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYKRGEELA
|  ..| .|    |  ||||.    .    ||.|  .   | |.  | |||| . |.. .|||. |..|  ||||..  || .   ||.|.| | ||.  
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGk.eksaeyfPsklGekar

FGSAsvtLQLTNHQEDYIHRQLRVTYTPRDTPPETRV-VHHFSFTSWPRSGAPSNGSGMIDLIDQVqkrqqQTGNKPILVHCSAGIGRTGAFCALSIAIE
.|      . . .. . |.. ..|.      . |..| | .  .  |.  | | |    . |.. .     .. .|||.||.|||.||||..    ||.|
igrl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililiale

RVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDY
 ....  . | .....|| .| . .|   ||....| .|..
slrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2400-2645 5.5e-36 118.7 In-house 52-299 (310) alignment 
Range on Protein: 2400-2645
Range on HMM: 52-299/310.0
NKLRNRYANIQCYDHSRVKLTPVEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPdTVGRSERFG
.  .|||... | | |||||.      .||| ||...     . || .||||  || |||||...  . ....| .  |. | ||  ||| ..| .| .|
ymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp.slgvtetyg

PISVTFIKSTS-HADYCIREFEI----QTQDEKTT----RSIKQFHYTSWPDFGVPRHPtpliqfIHTVR-RHHKYTDKRPMIIHCSAGVGRTGTFITID
 | || .  .|   . |     .       ||. .      ..  ..  ||| |||          |||  |      . | ..|||||..|... ....
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpqrllaqvrhgpcvvhcsagkdrlyvvvalk

SEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVeILNTGKTDIGIE
 .....|.  ...  . . ... .|   .||| |...|.   . |.  |.|..  .
lkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevaek
subfamily_ptpA1_pd Subfamily ptpA1 2686-2890 8.9e-36 118.5 In-house 43-256 (418) alignment 
Range on Protein: 2686-2890
Range on HMM: 43-256/418.0
RNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNcYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKeQFVMSAQYWPYKRG
 .  |  |||  | || .| ||.| ||  . ||||||| .|||   |. .|..| |  ||. |||.|. |... .||||.   |.   .   .||| . |
dkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsresen.crikcdrywpeqig

EEL---------AFGSASVTLQ--LTNHQEDYIHRQLRVTYTprdtpPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQT-----GNKPILVH
 |           ||. || |   . . . . | |..|.|.       ||| . .. .  ||    |     . .|.  . .||.|       | ||.||
geqfsiygngnevfgtysvelveviqdpereiitrnirltfe.....getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivh

CSAGIGRTGAFCALSIAIERV
||||.||||.||.  | ....
csagvgrtgtfctavimmkkl
PTPc_DSPc_SM00012 2532-2632 1.7e-35 116.8 In-house 2-104 (105) alignment 
Range on Protein: 2532-2632
Range on HMM: 2-104/105.0
IKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTD-KRPMIIHCSAGVGRTGTFITIDSEMQRADQE-RELNPYQFVRQMRENRNHMVQTEAQFVFIHD
.|..|||.|||.|||........... |.....  . . |...||||||||||||...|  .|. ..| .|.. .|.|...|. |..|||||.|..|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALV
|| 
all
0051082 (Phosphotyrosine protein) phosphatases II 2427-2631 2e-35 116.9 In-house 3-149 (151) alignment 
Range on Protein: 2427-2631
Range on HMM: 3-149/151.0
HDYINANFIHGYnrdneFIATQGPLPdtigDFWRMVWDYESPTVVMLTNLQEKMrvKCTQYWPDTVgrserfgpisvtfikstshadycirefeiqtqde
 ||||.... |.     .....|||.    ||.......   |.|.|....|    .|..|.|..                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

kttRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRhhkyTDKRPMIIHCSAGVGRTGTFITIDSEMQRadqereLNPYQFVRQMRENRNHMVQTEAQFVF
   . ........|||.|.| ..  ...|.. ...    ... |...|||||.|||||.. ..  ...      ..... ....|. | ..||.. ||.|
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

IHDAL
.. ||
qlfal
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2687-2932 2.1e-35 116.8 In-house 51-285 (290) alignment 
Range on Protein: 2687-2932
Range on HMM: 51-285/290.0
NDANK--DKNRLHNALPYDHNRVKLTKipGEIGsDYINASFIDGYKAknCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYKR
 |.|    ||| ..    |  || |    |  | ||. | ...| ||   .| .| .  .|  |.|.|. ...|..|||| .  |. .    .||.| | 
fdkntefkknrykdvvcndktrvilkd..GydG.dyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGk.akceqyypeke

GEELAFGSASVTLQLTNHQEDYIHRQLrVTYTPRDTPpETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRqqqTGnkPILVHCSAGIGRTGAFCALS
|| |.||. .|.  . ..... | ... ..   .|.     ...|.   |||    .     .. ..  ..|    .|  |. |||||||||||.| |. 
GevltfGeitvlcseeddkdaniikkt.lsvrdkdsG.kehklkhlkikswpdksvalstlallrtlrilrka...sG..pvvvhcsaGiGrtGtfvaie

IAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAES
.... .   . ... ..|. ||  |.  ||   ||. . ...||.  .
vglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkd
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2662-2931 2.3e-35 116.8 In-house 21-288 (305) alignment 
Range on Protein: 2662-2931
Range on HMM: 21-288/305.0
ETGYSHEFSRLQSeRAHFDDFYSARNDANKDKNRLHNALPYDHNRVKLtkiPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVI
 .|   ||. ..     |. . . ..  ...||| ..    |.|||||    |    .|| | ..      . .| .||| ..|  ||| |  ...|  |
paglraefvamkr.fndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveai

VMLANTEEKEQfVMSAQYWPYKRGEELAFGSAS--VTLQLTNHQEDY--IHRQLRVTYTP---RDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQV
 || |  ||      ..|.. | ...| |      .....   ..     . . .|| |      .  ..| | |. .  ||  | |.    ...|. . 
fmlcnllekga.kkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka

QkrqqqTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEH-IVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAE
.     .   || |||||||||||.   |   ....   . | .   |....| ||   .|  .||.|... ||.| .
r.....pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
0049260 (Phosphotyrosine protein) phosphatases II 2725-2923 7.2e-35 115.3 In-house 1-143 (152) alignment 
Range on Protein: 2725-2923
Range on HMM: 1-143/152.0
FIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEkEQFVMSAQYWpykrgeelafgsasvtlqltnhqedyihrqlrvtytprdtppet
|||||. .. .||.|.| .|||.|||.|. |.....|||| . .|   ..  .||.                                            
fidgyampfefiatqgpgpntladfwrmlkelgittivmltelle.lgklkceqyi............................................

rvvhHFSFTSWPRSGAPSNGSGMIDLIDQVQKRqQQTGNKPILVHCSAGIGRTGAFCALSIAIervkveHIVNIYNIVKHLRTQRAHMVQNLDQYVFIY
    .. .. || .|.|..   ...|.. ..|. ..  ..|.|||||||.||||...|. . .      . |.....|...|..| ..|.| .|. |.|
....qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2399-2627 7.9e-35 115.0 In-house 49-273 (301) alignment 
Range on Protein: 2399-2627
Range on HMM: 49-273/301.0
MNKLRNRYANIQCYDHSRVKLtpVEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERF
..| ..|| .. |  .. |..  ..|     | ||.|    . . ||||||||..|  ||| |.  |.  ..|||..  ||.  ||..| | ..... . 
lpkdkhryptvPckPstavev..ivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GPISVTFIKSTSHA--DYCIREFEIQ-TQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRhhkytDKRPMIIHCSAGVGRTGTFITIDSEMQRA
|  ...  .. .    .   |..|.. . .. .||..  . |..|.| |||.  . | .... |..      ..|...|||||.||. .||. .   .. 
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk.....sekPivvhcsaGiGrsvafigteylarev

DQERELNPYQFVRQMRENRNHMVQTEAQFVFI
. .....  . ....||.| . |||. |. ..
eadptieltealkhlrehrwngvqtnsqlywm
PTPc_DSPc_SM00012 2827-2927 2.9e-34 112.8 In-house 2-104 (105) alignment 
Range on Protein: 2827-2927
Range on HMM: 2-104/105.0
VHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTG-NKPILVHCSAGIGRTGAFCALSIAIERVKVE-HIVNIYNIVKHLRTQRAHMVQNLDQYVFIYR
|.|. .|.||  |.|.... ...|...|.| ... . .||..||||||.|||| |.||.|...... | . |.|..|||.||.||..|||...||.|.||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AIL
|.|
all
0051082 (Phosphotyrosine protein) phosphatases II 2718-2926 5.2e-34 112.4 In-house 3-149 (151) alignment 
Range on Protein: 2718-2926
Range on HMM: 3-149/151.0
SDYINASFIDGYkakncYIAAQAPkdntLNDFWKMICEQQVSVIVMLANTEEKEqfvMSAQYWPYKRgeelafgsasvtlqltnhqedyihrqlrvtytp
|||||.|...|.     ... ..|    |.||.... |.....||.| ..|| .   . ..|.|                                    
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg...ycpeylpelg.................................

rdtppetRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKrqqqTGNKPILVHCSAGIGRTGAFCALSIAIERvkvehiVNIYNIVKHLRTQRAHMVQNLD
       . |.|. ...||  | | .   ..........    ..|.|.|||||||.||||...|| . ...      |... .....| .| ..||  .
.......ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

QYVFIYRAI
|..|...|.
qflfqlfal
0044763 (Phosphotyrosine protein) phosphatases II 2411-2637 9e-34 112.0 In-house 1-173 (178) alignment 
Range on Protein: 2411-2637
Range on HMM: 1-173/178.0
CYDHSRVKLTPVED-SPHDYINANFIHGYnrdneFIATQGPLpdtiGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGrserfgpisvtfikst
..|..||.|...|.    |||||..| ..     ..... |      |........   ..|.||. .| ...|| .|||.  |                
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

shadycirefeiqtqdekttrsiKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKyTDKRPMIIHCSAGVGRTGTFITIDSEMQRadqerELNPYQFVRQ
                        |.... .||.|||  .  . .|.. ...... ....| ..||||||||.||.. ..  ...      |.... ...
.......................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

MRENRNhMVQTEAQFVFIHDALVEILNT
.|| |. .|... |  ....   ..|. 
vrerRp.ivpnpgqlrqLyefelrllke
0044763 (Phosphotyrosine protein) phosphatases II 2701-2925 9.7e-34 111.9 In-house 1-166 (178) alignment 
Range on Protein: 2701-2925
Range on HMM: 1-166/178.0
PYDHNRVKLTKIPGEIGSDYINASFIDGYkaknCYIAAQAPkdntlNDFWKMICEQQVSVIVMLANTEEKEQFVmSAQYWPYKRGeelafgsasvtlqlt
|.|..||.|....|. .|||||||.|...     |.... |      |......|. ...||.|... |  ..  . .||| . |               
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflk.cdpywpeeag...............

nhqedyihrqlrvtytprdtppetrvvHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQqTGNKPILVHCSAGIGRTGAFCALSIAIERvkveHIvNIYN
                            .. .. .| .|.|.  . . .... ... .. . ..|.|||||||.||.|...|. . ...    .. ....
...........................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.slee

IVKHLRTQRAhMVQNLDQYVFIYRA
.....| .|  .|.| .|. ..|. 
aielvrerRp.ivpnpgqlrqLyef
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2678-2930 9.8e-34 111.6 In-house 35-344 (350) alignment 
Range on Protein: 2678-2930
Range on HMM: 35-344/350.0
HFDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIP--------GEIGSDYINASFIDGY------KAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVM
  .|.  .       ||| .| |||.|.|||| | .           ..|||||...         ...  |||.|||  .|..||.|.| . .| ||..
psnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvils

LANTEEKEQfVMSAQYWPYKRGEE----------LAFGSA-----SVTLQLTNHQEDYIHRQLRVT--YT---PRDTPPETRVVHHFSFTSWPRSGAPSN
|..  | .      .||.    ..             |       |. .. .  ..| |  .  .   ..    . .. .  ||... .  |. ..   |
ltsdvelnl.ekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlsllln

GSGMID-------LIDQVQKR--QQQTGNKPILVHCSAGIGRTGAFCALSIAIE-----------RVKVEHI----VNIYNIVKHLRTQRAHMVQNLDQY
   ..        |||.   .   ..   .|||||||||.|||| ...|   ..            .|..        |  ||..|| ||  |||||||.
PesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqf

VFIYRAILDYA
.||| |.| | 
ifiYeallfyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2402-2555 1.1e-33 111.3 In-house 35-189 (297) alignment 
Range on Protein: 2402-2555
Range on HMM: 35-189/297.0
LRNRYANIQCYDHSRVKLTPVEdSPHDYINANFIHGYNR--DNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERFG
 .||| .|  .| .||||  |  . .|||||...   .   |  .| .|||| .|. |||..|.. .  ..||...|||  | ||. |||..|.   . |
rknryrdilatddtrvkllrvi.terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkag

PISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQF
 . | |. |||     .   |.|    . .| ..   . |||| |||     | .|
dvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2687-2929 1.4e-33 111.1 In-house 32-269 (285) alignment 
Range on Protein: 2687-2929
Range on HMM: 32-269/285.0
NDANKDKNRLHNALPYDHNRVKLTKipgeIGSDYINASFID-GYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKeQFVMSAQYWPYKRG
 .|| | ||  .    .  || | .       ||| ||..    | .. ||..| |  .||.|||.|| ..... ..||.   |       | |.| | |
yeanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeg.gvekcalyypeklg

EELAFGSASVTLQLTNHQ--EDYIHRQLRVTYTpRDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQtgNKPILVHCSAGIGRTGAFCAL
| . ||   .||   . .     |   | |. |  |.  |   . |     ||   || .   ||.|   |.| . .  .||| ||||||.||| .|  .
evvkfgkyeitlteckeeaiagtilnaltvint.edasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgi

SIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDY
  |  |.  .  ... .||. .|. | . ||.  |..|.|  ...|
dyatirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2721-2923 3e-33 109.9 In-house 78-279 (301) alignment 
Range on Protein: 2721-2923
Range on HMM: 78-279/301.0
INASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfVMSAQYWPYKRGEELAFGSASVTLQLTNH--QEDYIHRQLRVTYTPR
| | .|.     . .||.|.| .|| .||| |.   .|  ||||... ||..  . ..| | | .|.|  |  ..... ...  ... ..|.|.|. . .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekle.ekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

DTppETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKrqqqtGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQ
.   .|| | |. ...|.  | |     . ||.. |.|      .|||.|||||||||. || .  .   .|. .  ... . .|||| .| . ||.  |
kf..atrtvthyqysewtdrgvPkshaelfdlmelvkk.....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq

YVFI-----Y
  ..     |
lywmtlGtvy
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2403-2637 3.2e-32 106.5 In-house 46-278 (312) alignment 
Range on Protein: 2403-2637
Range on HMM: 46-278/312.0
RNRYANIQCYDHSRVKLTPVEDSphdYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRS----ERF
 ||| ||||.|  |  |.  |.    || |||..   . . |..||||| .|.  ||...    | ....|. . |    ||..|  | ||       | 
lnrypniqcwdrgrftlagdenf...yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

GPISVTFIKSTSHADYCI--REFEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRhhkytDKRPMIIHCSAGVGRTGTFITIDSEMQRAD
   ..| |.   ..   |  | . .  .       .... ..|||| |.|       ... .|..     ||.|.| |||||||||||.. |.| .    
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk.....dkkpviahcsagvgrtgtlaliesmiaalr

QERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNT
. |  |  .    .| .|   |.. .|.|.   ...|.| .
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2662-2930 5.4e-32 105.4 In-house 25-285 (302) alignment 
Range on Protein: 2662-2930
Range on HMM: 25-285/302.0
ETGYSHEFSRLQSERAHFDDfySARNDANKDKNRLHNALPYDHNRVKLTKIPgeigSDYINASFIDGYKAKNCYIAAQAPKDNTL---NDFWKMICEQQV
..   .|| .... ... .        .| .||. ..   .|.|.|||.. |     .|.||| ..  . ..  | || || ..    ..||.|. ....
taevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

SVIVMLANTEEKEQfVMSaQYWPYKRGEELAFGSASVTLQLTNHQEDYIhRQLRVTYTPRDTPpETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVqKRQ
  .|.|. .|| ..  .| ...| | |. . .|.  |  .  ...|.    .. .   | .   .. ..    .| |. .  | . . .|  . .|   .
vsvvilvgeeelkk.tls.elfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcs.nsvlanvyvltnWkqkkvpvkyaeliktaakv.fak

QQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
.. .......    |.|| ||| .| .|.|... .. .|| .||| .|.||...|..|.|||..|.|.| | 
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2730-2924 2.3e-31 103.5 In-house 2-198 (199) alignment 
Range on Protein: 2730-2924
Range on HMM: 2-198/199.0
KAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLaNTEEKEQFVMSAQYWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTpRDTPPETRVVHH
|..  |||.| |  .|. |||.|. |     |||. | ..|.. .  . |||        .|| ||| .    . ||    | .|     .|| || . |
kgqrryiatqhplretmadfwqmvwetgsghivmv.nddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnn.ttappstreish

FSFTSWPRSGAPSNG--SGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALSIAIERVK--VEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYR
. ||||    .|      |..    .| |. .|  . |..|||| | | || | || | .   .     .|..... | ||  |  ..  |..| |||.
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2731-2924 3.8e-31 102.8 In-house 2-197 (198) alignment 
Range on Protein: 2731-2924
Range on HMM: 2-197/198.0
AKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLaNTEEKEQFVMSAQYWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTpRDTPPETRVVHHF
..  |||.| |  .|| |||.|. |     |||. | ..|.. .  . |||        .|| ||| .    . ||    | .|     .|| || . |.
gqrryiatqhplretladfwqmvwetgsghivmv.nddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnn.ttappstreishy

SFTSWPRSGAPSNG--SGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALSIAIERVK--VEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYR
 ||||    .|      |..    .| |. .|  . |..|||| | | || | || | .   .     .|..... | ||  |  ..  |..| |||.
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2691-2930 2.4e-30 100.7 In-house 20-259 (290) alignment 
Range on Protein: 2691-2930
Range on HMM: 20-259/290.0
KDKNRLHNALpYDHNRVKLTKIPGEIGSDYINASFIDgYKAKNCYIAAQAPKDN-------TLNDFWKMICEQQVSVIVMLANTEEKEQFVMS---AQYW
. ..||...|   ..|| |      . .||| |...  .    . |. |.|. .       |...|| |. . .|  .||| . |||..   .   |.| 
emdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYtprDTPPETRvVHHFSFTSWPRSGAPSNGSGMIDLIDQVQkrQQQTgnkPILVHCSAGIGRTGAF
| . |||| |.  .|  .   ...| ..|.| |..   |   |   | |  . .|  . .. .   ...||..|.  ...|   |..|||  || |  |.
pesvgeelkfkgltvkCkskekeddvetRelvvkf...ddeeeft.vtHsllkgWnklnvqedtktllsliqkvk..askt...pvivHcvdGiSrsAal

CALSIAIERVK-VEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
 |. ..   .   .. |.. ...| || |||.....  .. |.  .|. .|
aaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivlla
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2689-2932 4.1e-28 92.8 In-house 51-292 (310) alignment 
Range on Protein: 2689-2932
Range on HMM: 51-292/310.0
ANKDKNRLHNALPYDHNRVKLTkIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEkEQFVMSAQYWPYKrGEEL
 .  |||  . .  |  ||||. |      ||| | ..     .. .| .| | . |. |||.|| ...   |..| .. | |    .  |||   |   
kymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvge.egrpkcvgywpsl.gvte

AFGSASVTlQLTNHQEDYIHRQLRVTYTPRDTPPETR-------VVHHFSFTSWPRSGAPSNGSGMIDlidqvQKRQQQTGNKPILVHCSAGIGRTGAFC
..|   || .|..  |..   .| ||. | . | . .        |    .  ||  | | .    .      |.   |    | .||||||..|... .
tygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.....qrllaqvrhgpcvvhcsagkdrlyvvv

ALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAES
|| ..|....  . |.. ... .|. .||  .|.  ||..| |  . .| .
alklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarg
subfamily_CG42327_pd Subfamily CG42327 2398-2562 5.8e-28 92.5 In-house 26-193 (319) alignment 
Range on Protein: 2398-2562
Range on HMM: 26-193/319.0
PMNKLRNRYANIQCYDHSRVKLTPVEDSPH-DYINANFIHGYNR-DNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVG--
.  | ..|..|.    ..|| |  . | ..  |..|... ||.  .| .||.| .| |.  ||||.||.  | ..| ||.|.|.   .|..|.|   .  
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

RSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYtSWPDFGVPRHPTPLIQFIHTVRRH
  . .| | ||. .  ..  | |  . ..  |.. .| .  . |  |.. .|| ....||  .  ||  
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_egg_pd Subfamily egg 2679-2929 1.1e-27 91.5 In-house 29-269 (307) alignment 
Range on Protein: 2679-2929
Range on HMM: 29-269/307.0
FDDFYSARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQfvmSAQ
   .  | .| |..| | .     |  ||||    |    |.| |  ..|    | .| ||||  || .|||.|. ...|  ||||. . | |.      
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeser...cey

YWPYKRGEELAF--GSASVTLQLTNHQEDYIHRQLRVTYTPRDtpPETRVVHHFSFtSWprsgapSNGSGMIDLIDQVqkRQQQTGNKPILVHCSAGIGR
|||    . | .  ||  ..    ... | . |  ..     |   | | . |.    .       | | .   .  .  |. .   ||..|..  |. .
ywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqg.dv......nnssdvysplrvl..rklrnlskpvvvqdilGvsk

TGAFCALSIAIERVKVEHIV--NIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDY
.... |. ||.  .    |.   . . |. || .|   |.   .|.|.|| .| .
aatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_egg_pd Subfamily egg 2387-2632 3e-27 90.1 In-house 27-267 (307) alignment 
Range on Protein: 2387-2632
Range on HMM: 27-267/307.0
SPNPSVDVCLNPMNKLRNRYANIQCYDHSRVKLT-PVEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKmrVKCT
. . |.  ...  |. . |   ..| | |||||  .      |.| || ..|    |||| .| || .|  ||||||.  | . .||||  .|    .| 
vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPDTVGRSERF--GPISVTFIKSTSHADYCIREFEIQTQDE-KTTRSIKQFHyTSWPDFGVPRHPtpliqfIHTVRRHHKYtdKRPMIIHCSAGVGRT
 ||| .   | ..  | . .. .|  |.||   |  ...     .  | .. .    .   .    |      .. .|.  .    .|.....  || ..
yywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysp......lrvlrklrnl..skpvvvqdilGvska

GTFITIDSEM---QRADQERElNPYQFVRQMRENRNHMVQTEAQFVFIHDALV
.|...|.  .    |    .     . |  .| .|.  |..  ...|..  ..
atlvaieiallsllrGpitks.lvlravvflrlrrrlsvesvllylfvyrlvl
0048076 (Phosphotyrosine protein) phosphatases II 2778-2927 6.8e-27 89.3 In-house 1-140 (145) alignment 
Range on Protein: 2778-2927
Range on HMM: 1-140/145.0
QYWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDTPpetRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQtgNKPILVHCSAGIGRT
.|||..  . | .||  ..|.| . ..  | . |..|.....     | . .. ...||  |.|.  . .......... ...  ..|.|||||||.|||
pywpseilpglylgslptaldlellkdlgittvlnltselelle...rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRt

GAFCALSIAIErvkvEHiVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAIL
|...|. . ..    .. |.........|.|| ..|.| .|. |.|...|
gtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2529-2654 9.3e-27 88.4 In-house 88-213 (440) alignment 
Range on Protein: 2529-2654
Range on HMM: 88-213/440.0
TRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIH
.|..||.|| .||| |||.   |....|. |   .. . . |...|||||.||||  |..|| .. | .  ... . |.  ||.|| .||||  |..|.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DALVEILNTGKTDIGIEQLEARMAEL
.|..| | .| | |  ...  |. ..
eavlegllcgdtliledditerveqi
subfamily_CG42327_pd Subfamily CG42327 2689-2856 9.9e-27 88.4 In-house 27-192 (319) alignment 
Range on Protein: 2689-2856
Range on HMM: 27-192/319.0
ANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGYK-AKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEqFVMSAQYWPYKRGEE
. |||.|. |..|  . || | .|. .  . |..||.. ||. |.| |||||.. ...  |||... |||  ||| |..  |.    . |.|.| | . .
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselG.ikvcaeylPtketld

--LAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDtppETRVVHHFSFtSWPRSGAPSNGSGMIDLIDQVQK
   ..|   |||.  . .. |.   | .    ..   |.| . |. .  |. .. |.. . .| .. .|..
ntslyGdilvtlkgrevkdryaistlllkrvdke...esrelthywy.kwleaevPaeeaaliamllevrs
0048179 (Phosphotyrosine protein) phosphatases II 2779-2924 1.5e-24 81.8 In-house 2-139 (144) alignment 
Range on Protein: 2779-2924
Range on HMM: 2-139/144.0
YWPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTpRDTPPETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQqtGNKPILVHCSAGIGRTG
..|..  . | .||  ..|.| . ..  |   ...| . .. . ..| .... ...||  |.|.  . ...... ... ..   ..|.|||||||.||||
snpseilpglylgslptaldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtg

AFCALSIAIervkVEHiVNIYNIVKHLRTQRAHMVQNLDQYVFIYR
...|. . .    ... ..........|..| ..|.| .|. |...
tlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2737-2923 7e-24 78.8 In-house 95-281 (302) alignment 
Range on Protein: 2737-2923
Range on HMM: 95-281/302.0
AAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQFvMSAQYWPYKRGEELAFGSASV-TLQLTNHQEDYIHRQLRVTYTP-----RDTPPETRVVHHF
    || .||. .| .| . .|...| |..  |.|.    |.|.  | |.|| ||  .| |... .. |..  ..  . ||      . .    . |. .
kpivpkkstlekhwalieqynvaivvqlcsfvedeek.kcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdil

SFTSWPRSGAPSNGSGMIDLIDQVQkrqqqTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIY
 |..||  ||| .    .|..   .     .  | .|||||||.||||.. |.   |.  . ... .. .||. .|. |   ||. .| ... 
afsawpdhGapkeaytaldilkfce.....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2442-2627 7.6e-24 79.0 In-house 5-196 (199) alignment 
Range on Protein: 2442-2627
Range on HMM: 5-196/199.0
NEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERFGPISVTFIKSTSHADYCIREFEI--QTQDEKTTRSIKQFHYTS
  .|||| || .|. |||.|||.  |  .||. . | .  .    ||| |   . ..| .|||    |...||.|  . .  .|    .|| | .. .||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDFGVPRHpTPLIQFIHTVRRH-HKYTD--KRPMIIHCSAGVGRTGTFITIDSEMQRADQER--ELNPYQFVRQMRENRNHMVQTEAQFVFI
| .   |   . .. |. . |   .|| .    |.|.||| | | || |...|  ..  .. .   .. ..  ...|. |  .. .  .. ||
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2442-2627 8.1e-24 78.9 In-house 4-195 (198) alignment 
Range on Protein: 2442-2627
Range on HMM: 4-195/198.0
NEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERFGPISVTFIKSTSHADYCIREFEI--QTQDEKTTRSIKQFHYTS
  .|||| || .|. |||.|||.  |  .||. . | .  .    ||| |   . ..| .|||    |...||.|  . .  .|    .|| | .. .||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDFGVPRHpTPLIQFIHTVRRH-HKYTD--KRPMIIHCSAGVGRTGTFITIDSEMQRADQER--ELNPYQFVRQMRENRNHMVQTEAQFVFI
| .   |   . .. |. . |   .|| .    |.|.||| | | || |...|  ..  .. .   .. ..  ...|. |  .. .  .. ||
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2390-2644 2.2e-23 77.3 In-house 39-289 (303) alignment 
Range on Protein: 2390-2644
Range on HMM: 39-289/303.0
PSVDVCLNPMNKlrNRYANIQCYDHSRVKLTpveDSphDYINANFIHgYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWP
 | .  .. |.|  ||.... | |||.|||.   ||   || |....  . ..  | || ||. |  |||.|. .     |..|    |  ..     .|
vsknqfvknmdk..nrfvdvicldhskvkls...ds..syihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp

---DTVGRSERFgpISVT-FIKSTSHADYCIREFEIQTQDEKTTrsIKQFHYTSWPDFGVPRHPTP-LIQFIHTVR-RHHKYTDKRPMIIHCSAGVGRTG
   | .   ||.  | |  | .      . ..   .   | |.   ..  || .||   .| . .| ... |  ..    ||.| .| .    .|.||.|
rnqdflkfeers..irvgefkrvelgdgwvlkvlsvsngdyksf..lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgrag

TFITIDS-EMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVE-ILNTGKTDIGI
||  ...  .   ...  |.  . . ..|. | | ||  .|| ...  | | .|. | . . |
tfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklai
0048076 (Phosphotyrosine protein) phosphatases II 2487-2633 2.4e-23 77.8 In-house 2-141 (145) alignment 
Range on Protein: 2487-2633
Range on HMM: 2-141/145.0
YWPDTVGRSERFGPISvTFIKSTSHADYCIRE-FEIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKytDKRPMIIHCSAGVGRTGTF
|||. .  .  .|..  | ..    .|. |.  . . .  |  .| . |..|..|||.|||  .  |..|.. .....|  ...|...|||||||||||.
ywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealk..eggpvlVHCsaGvgRtgtl

ITIDSEMQradqeRELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVE
. ..  ..     . ..... ....|. | ..|... |. |..... |
vaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2449-2627 3.4e-23 76.5 In-house 98-280 (302) alignment 
Range on Protein: 2449-2627
Range on HMM: 98-280/302.0
GPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERFGPISVTFIKS-------TSHADYCIREFEIQ--TQDEKTTRSIKQFHYTS
 |  .|.  .| .. .|.   || |... |.   ||..|. | ||   .||  .|. ..        |   .. .   ||.   . .|. .... .....
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDFGVPRHPTPLIQFIHTVRRHhkytdKRPMIIHCSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFI
||| | |... . .. ..    .     |. ...|||||||||||...|   .|   ...  .  . |  .|. |   ||.| | ...
wpdhGapkeaytaldilkfcesy.....kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2689-2927 8.2e-23 75.5 In-house 46-276 (303) alignment 
Range on Protein: 2689-2927
Range on HMM: 46-276/303.0
ANKDKNRLHNALPYDHNRVKLTKipgeigSDYINASFIDGYKAKNCyIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEQFVMSAqYWPyKRGEEL
 | ||||. . .  || .|||.       | || ||...    |.. | .| |   |  |||.|| ||.| ....|    | ...      .| .  . |
knmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggds.vfp.rnqdfl

AFGSASVTLQLTNHQEDYIHRQLRVTYTPRDTPPETRVVHHfsFTSWPRSGAPSNGSG-MIDLIDQVQKRQ-QQTGNKPILVHCSAGIGRTGAFCALSIA
 |   |. .   .. |     .|.|      .      |||  . .|| .  ||.||  ..  | |.|    . . ..| .    .| ||.|.|. .  |
kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhh..ykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

IERVKVEH-IVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAIL
   .. |   ... . .. .|  | | |||| |. ..|  . 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytlla
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2691-2940 1.4e-22 74.8 In-house 44-286 (312) alignment 
Range on Protein: 2691-2940
Range on HMM: 44-286/312.0
KDKNRLHNALPYDHNRVKLTkipGEiGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKE----QFVMSAQYWPYKRGE
|| ||  |   .|  |  |.   |.    || | |.      . ....|.| .||   ||..      . |..|.   |         .|      .  .
kdlnrypniqcwdrgrftla...gd.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

ELAFGSASVTLQLTNHQEDYI-HRQLRVTYtpRDTPPETRVvHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQqqtgnKPILVHCSAGIGRTGAFCALSI
   .      ...  .  | | || |.|    . |  |...  |. ..|||  | |        |.  |.| .     ||.. |||||.||||... .  
hrvyteycteieiggkskdkithrvlkvvv..katgqeskl.nhyqwaswpdhgmpdscdtalrllsavkkdk.....kpviahcsagvgrtgtlalies

AIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESLNSYANFN
 |  ..     |. ..   || .||  |. . |||.  |..|..  |   |   .
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrne
0048179 (Phosphotyrosine protein) phosphatases II 2524-2629 1.7e-22 75.1 In-house 41-139 (144) alignment 
Range on Protein: 2524-2629
Range on HMM: 41-139/144.0
QDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKytDKRPMIIHCSAGVGRTGTFITIDSEMqradqERELNPYQFVRQMRENRNHMVQTEAQ
  |  .| . |.....|||.||| ... |..|.. ......  ...|...|||||||||||.....  .     .. |.... ....|. | ..|... |
epefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgq

FVFIHD
. |...
lrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2401-2490 2e-22 74.4 In-house 48-152 (350) alignment 
Range on Protein: 2401-2490
Range on HMM: 48-152/350.0
KLRNRYANIQCYDHSRVKLT---------PVEDSPHDYINANFIHGY----NRDNEF--IATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCT
  .||| ||  |.||||||              |. ||||||...      . . .|  ||||.||| |. ||....   . . ...||...|  . || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPD
.||..
rYWqe
subfamily_eak_pd Subfamily eak 2690-2932 2.6e-22 73.6 In-house 52-307 (332) alignment 
Range on Protein: 2690-2932
Range on HMM: 52-307/332.0
NKDKNrLHNALPYDHNRVKLTKIPGEiGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEkEQFVMSAQYWPYKRGEELA
. ..| . ...|||.. |.||    .    ||||| ..  .  . || . ..... .  ||.|. ||.   ||.|..  | ...  | .|.| |  ||| 
avnrn.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledve.lkleksdkyfpdktreelk

FGSASVTLQLTNHQEDYIHRQLRVTYTprdtpPETRVVHHFSFTSWPRSGAPSN-----------GSGMIDLID-------QVQKRQQQT--GNKPIlVH
||   |. .   ... .  |.| ..        ||  |.|. .  |     |               |.. ||         . |. . |   . || . 
fGildverkefvkrniletrllelskG.....nethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapi.iq

CSAGIGRTGAFCALSIAIERVKvEHIVNIYNI---VKHLRTQRAHMVQNLDQYVFIYRAILDYAES
.. |  |.|.|  . . |. .  ... | | .   .   ...| | |    |. ||| ..|||   
sarGsaraGvfvvidllirlid.nkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2427-2637 5.6e-22 73.2 In-house 46-257 (290) alignment 
Range on Protein: 2427-2637
Range on HMM: 46-257/290.0
HDYINANFIHgYNRDNEFIATQGPLPDT-------IGDFWRMVWDYESPTVVMLTNLQEKMRV----KCTQYWPDTVGRSERFGPISVTFIKSTSHADYC
 ||| ||..  .  . ..|.|| |. ..       | .|| |. . ..  |||| . .|| .      |..| |..|| . .|. ..|   .   . |  
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

IREFEIQTQDEKTtRSIKQFHYTSWPDFGVPRHPTPLIQFIHTVRrhhkyTDKRPMIIHCSAGVGRTGTFITIDSEMQRAD-QERELNPYQFVRQMRENR
.|| ... .||.    ..   . .| .  |....  |.. |..|.     . | |.|.||  |. |  .. .|.  .|    .. ...  . . ..|..|
tRelvvkfddeee.ftvtHsllkgWnklnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

NHMVQTEAQFVFIHDALVeilnT
....... .. |.  ..|     
alaitsalelafvdagiv....l
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2400-2632 2.1e-21 70.6 In-house 51-282 (302) alignment 
Range on Protein: 2400-2632
Range on HMM: 51-282/302.0
NKLRNRYANIQCYDHSRVKLtpvEDSPHDYINANFIHGYNRDNEFIATQGPLPDTI---GDFWRMVWDYESPTVVMLTNLQEKMRvKCTQYWPDTVGRSE
|  .|.  .....|. .|||   | .| .|.||  ..  .  .. | .| |  |.     .|||||.. .  .||.|   .|  .    ...| . |  .
nlkknqsedvpildsnlvkl...eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyk

RFGPISVTFIKSTSHADYCiREFEIQTQDEKTTRSI--KQFHYTSWPDFGVPRHPTPLIQFIHTVrRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEMQR
 .| . |   |  .  .    .. |    |  . |.  .  . | |..  || . . ||. .. |  ..|   . ...|    |.|| |.|.|    ...
eygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlavavek

ADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALV
 ... | |  . |...|..| ..|..  |.|... ||.
lqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2454-2629 7.2e-21 69.4 In-house 40-215 (255) alignment 
Range on Protein: 2454-2629
Range on HMM: 40-215/255.0
TIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERFGPISVTFIKstSHADYCIREFEIQTQ--DEKTTRSIKQFHYTSWPDFGVPRHPTP
|.  |....   .. .||||....|. ..|| .|.|       ..  ..||  |  | ||  .|  || ..  . | |. .| ..|. |..   |. .  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LIQFIHTVRrhhkytDKRPMIIHCSAGVGRTGTFITIDSEMQ------RADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHD
. . .. ||      | .....|||.|.||. .|. ...  |      .  .  ||.  ......|..|.  ..|  |. |   
ilnilkvvr......dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsil
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2571-2639 8.8e-20 64.9 In-house 1-69 (69) alignment 
Range on Protein: 2571-2639
Range on HMM: 1-69/69.0
MIIHCSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGK
|..|||.| |||||||.|  || |   |. .. .  |. ||  |  ||  | ...|||||||| |  ||
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklGk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2730-2930 1.2e-19 65.5 In-house 32-221 (255) alignment 
Range on Protein: 2730-2930
Range on HMM: 32-221/255.0
KAKNCYIAaqapkdnTLNDFWKMICEQQVSVIVMLANTEEkEQFVMSAQYWPYKRGEELAFgsASVTLQLTNHQEDYIHRQLRVTYTPRDtPPETRVVHH
| || |.        |.. |...|  .. .|.|||.. .| |. .   .|.| .. | | .  | |..  |.   | . | |..| |  .   .|. |.|
krknlysl.......tvdkfyqtivqtktevvvmlcdfae.egvekcssyfplekdeklkl..advnvtttkssadvvlrtleitstlge.kkkthtvkh

FSFTSWPRSGAPSNGSGMIDLIDQVQKrqqqTgnKPILVHCSAGIGRTGAFCALSIAIE----RVKVEHIVNI--YNIVKHLRTQRAHMVQNLDQYVFIY
.|.. |.   || .   .  ..  |..    .  |...||||.||||. ||    ..       ..  . |..   .....|| .|.  ...  |  |  
ysykGWieknaPelareilnilkvvrd....s..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsi

RAILDYA
  .||. 
lmvldlv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2823-2928 3.4e-19 63.5 In-house 87-192 (440) alignment 
Range on Protein: 2823-2928
Range on HMM: 87-192/440.0
ETRVVHHFSFTSWPRSGAPSNGSGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFI
|.|..... . .||  | |   . .. .|..|.. |...|| |.||||||| ||||   |.   .  .|    ..|..... .| .| .|||  .||.|.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YRAILD
. |.|.
heavle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2684-2804 7.9e-19 62.2 In-house 90-200 (244) alignment 
Range on Protein: 2684-2804
Range on HMM: 90-200/244.0
SARNDANKDKNRLHNALPYDHNRVKLTKipGEIGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEqfvmsaQYWPYk
 | |  |  |||   .||.| ||| |.|  | .|  ||||||.        || .| |  .|  |||||. |. | |.|.|   ||..      .|||  
dafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed......eywpd.

rGEELAFGSASVTLQLTNHQE
  | | .    .|. ||. .|
.seplewyeeditvtltdrde
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2572-2639 9.9e-19 61.5 In-house 1-68 (69) alignment 
Range on Protein: 2572-2639
Range on HMM: 1-68/69.0
IIHCSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVEILNTGK
..|||.| |||||||.|  || |   |. .. .  |. ||  |  ||  | ...|||||||| |  ||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklGk
I-set Immunoglobulin I-set domain 520-614 1e-18 58.9 Pfam-A 1-90 (90) alignment 
Range on Protein: 520-614
Range on HMM: 1-90/90.0
PDITELPANITVIQPVAAQFNCSANAIPQPTIQWIKNGATLSSNAKYTITTTSststdRSSTLTILDSTPLDADDYYCSVTNSVKTVTASATLTV
| .|. . ...| .  .....|...  |.|...| |.|  |.|. ....| ..      ..|||| . .. |...| | .|||.....|.|.|.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee.....aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_hpo-7_pd Subfamily hpo-7 2451-2631 2.2e-18 61.1 In-house 43-223 (263) alignment 
Range on Protein: 2451-2631
Range on HMM: 43-223/263.0
LPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERFGPISVTFIKSTShaDYCIREFEIQT--QDEKTTRSIKQFHYTSWPDFGVPRH
| .||  |....   .. .||||.. .|. ..|| .|.|       ..  ..|.  |. |  |  ..  |.    .. |.|. .|.. |. |..   |. 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PTPLIQFIHTVRrhhkytDKRPMIIHCSAGVGRTGTFITIDSEMQ------RADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDAL
.   .. .. .|      . .....|||.|.||.  |  ...  |      .  .  ||.  ......|..|.  ..|  |. |    .
areilnilkvar......nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
subfamily_hpo-7_pd Subfamily hpo-7 2732-2930 5.1e-18 59.9 In-house 37-227 (263) alignment 
Range on Protein: 2732-2930
Range on HMM: 37-227/263.0
KNCYIAaqapKDNTLNDFWKMICEQQVSVIVMLANTEEkEQFVMSAQYWPYKRGEELAFgsASVTLQLTNHQEDYIHRQLRVTYTPRDtPPETRVVHHFS
|| |.       .|.. |...|  .. .|.|||.. .| |. .   .|.| .. | . .  | |..  |. |.| . . | .. |  .   .|. |.|.|
knlysl....lvqtidkfyqtivqtktevvvmLcDfne.egvekcssyfPlekdekqkl..anvnvcttkvqsdvllktlellstlge.Kkkthtvkhys

FTSWPRSGAPSNGSGMIDLIDQVQKrqqqtgNKPILVHCSAGIGRTGAFCALSIAIE----RVKVEHIVNI--YNIVKHLRTQRAHMVQNLDQYVFIYRA
.. |..  .| .   .. ... ...       |.. ||||.||||. ||    ..       ..  . |..   .....|| .|.  ...  |  |    
ykgWiekndpelareilnilkvarn......skslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilm

ILDYA
.||. 
vLdfv
I-set Immunoglobulin I-set domain 928-1021 1.3e-17 55.3 Pfam-A 2-90 (90) alignment 
Range on Protein: 928-1021
Range on HMM: 2-90/90.0
DITQIPTDITVIQPLQAQFNCSANAIPQPTIQWIRNGTILSSNAKYTITTTNststdRSSTLTIFDSTPVDAGDYYCFVNNNVKTVNVSATLTV
 .||...|..| .  .....|...  |.|...| ..|. |.|. ....| ..      ..|||| . .. |.|.| | ..|...... .|.|.|
kftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee.....aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_CG42327_pd Subfamily CG42327 2859-2933 1.5e-17 58.3 In-house 243-318 (319) alignment 
Range on Protein: 2859-2933
Range on HMM: 243-318/319.0
QQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVE-HIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYAESL
..  . |. |||| |.||||   |  |||....   . |.| ..| ..| .||. |.. .|| |||. .  ||. |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2532-2633 1.9e-16 54.7 In-house 217-342 (350) alignment 
Range on Protein: 2532-2633
Range on HMM: 217-342/350.0
IKQFHYTSWPDFGVPRHPTPLIQFIH---------TVRRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEMQ-------------RADQERELNP--YQFV
. |...  |.| ..  .|  ..| .          . . | .     |...|||||||||||..|.|| ..             . |.  ...    . |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RQMRENRNHMVQTEAQFVFIHDALVE
 ..|. |  |||.  ||.||..||  
nelrkqrismvqnldqfifiYeallf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2867-2927 4e-16 53.2 In-house 2-62 (69) alignment 
Range on Protein: 2867-2927
Range on HMM: 2-62/69.0
LVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAIL
.||||.| ||||.| |. . . |.| | .|.|.| |...|  |  || |  .|.||. |. 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2436-2526 4.3e-16 53.3 In-house 230-316 (440) alignment 
Range on Protein: 2436-2526
Range on HMM: 230-316/440.0
HGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKmrvKCTQYWPDTvGRSERFGPISVTFIKSTSHADYCIREFEIQTQDE
.|| . | ||||| ||  |. ||||.| ||.  |..|| .|..|    |. |||    ||  |||..|    |       .| .|.. ..|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvn.trsvtfgpftvghkgsenmnrvkvrtlelkykee
fn3 Fibronectin type III domain 1911-1995 4.7e-16 51.9 Pfam-A 2-85 (85) alignment 
Range on Protein: 1911-1995
Range on HMM: 2-85/85.0
APLNVGIVTDSSTSVQLSWNAPDslVQNGRITSYRIRYSIPFQTP-FNPVIVSAPSTTARIENLEKYTIYNFSVAAGTARGYGPYS
|| |. .   .|||..|||..|.   ..| ||.|...|.   ..   . . |....|.. ...|. .| |.|.|.| .. |.||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2379-2544 9.7e-16 52.1 In-house 74-234 (244) alignment 
Range on Protein: 2379-2544
Range on HMM: 74-234/244.0
GKIDINRSSPNPSV-DVCLNPMNKLRNRYANIQCYDHSRVKLTPVeDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQ
 .   |   |.|||   ..|| |  .|| .    .| .|| |.        |||| |.    |  |.| || || ||  |||.|. .     .|.|  ..
iqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskg.smgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsve

EKmrvkcTQYWPDTVGRSERFGPISVTFIKSTSHADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFG
|.      .||||.         |.||.       .    ..||... ... ...  |  . ||  |
ee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
I-set Immunoglobulin I-set domain 1025-1126 1e-15 49.3 Pfam-A 1-90 (90) alignment 
Range on Protein: 1025-1126
Range on HMM: 1-90/90.0
PTIALQMTTYTVNENSTVTFQCTGTGVPEPGITWYRNGNELSTSSRITINSGSpiqdgstliyqVSGSLEISPVADNDSDtTYNCTASNTAGRATDQFAL
|..  ...  .|.|...|...|| .|.||| ..|...|.||..|.|....  .            . .|.|| |  .|.. .|.|.|.| ||.|. .. |
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee...........aeytLtIsnvevsDeG.kYtckatnsagkaeakaeL

DV
 |
kV
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2868-2927 1e-15 51.8 In-house 2-61 (69) alignment 
Range on Protein: 2868-2927
Range on HMM: 2-61/69.0
VHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAIL
||||.| ||||.| |. . . |.| | .|.|.| |...|  |  || | ..|.||. |. 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
I-set Immunoglobulin I-set domain 318-417 2.4e-15 48.1 Pfam-A 1-90 (90) alignment 
Range on Protein: 318-417
Range on HMM: 1-90/90.0
PTVSSQMMNYVVDENSTVTFQCTGTGVPEPDITWYRNGVPITDtrfseltesmldS--------SsliysVNGSLTLNNAYNTDTDTgYSCTATNTFGNA
|... .. . .| |...|...|| .|.|||...|...| ...             |        .      . .||..|.   |... |.|.||| .|.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselks............sqrvkvtvee.....aeytLtIsnvevsDeGk.Ytckatnsagka

SDSFGLAV
. .. |.|
eakaeLkV
subfamily_eak_pd Subfamily eak 2401-2547 2.4e-15 50.7 In-house 53-196 (332) alignment 
Range on Protein: 2401-2547
Range on HMM: 53-196/332.0
KLRNrYANIQCYDHSRVKLTPVEDSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERFGP
  ||   .|  ||.  |.||.    .  ||||  .   .  ...| |  .  | .  ||.|| .  ||..|.| .  |.   |  .|.||      .|| 
vnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGi

ISVTFIKSTSHADYCIREFEIQTQDEktTRSIKQFHYTSWPDFGVPR
. |.  .   .. .  | .|..  .|  |  .. ...  | .. .|.
ldverkefvkrniletrllelskGne..thrvlhykvfGwtettlpk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2684-2739 8.8e-15 48.7 In-house 42-94 (95) alignment 
Range on Protein: 2684-2739
Range on HMM: 42-94/95.0
SARNDANKDKNRLHNALPYDHNRVKLTKipgEIGSDYINASFIDGYKAKNCYIAAQ
    .||  |||. | .|||  || ||       |||||| |.|||  ||||||||
vgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2849-2930 9.8e-15 48.7 In-house 249-344 (349) alignment 
Range on Protein: 2849-2930
Range on HMM: 249-344/349.0
DLIDQVQKRQ--QQTGNKPILVHCSAGIGRTGAFCALSIAIE--------RVKV--EHI--VNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
||||.   |.  ..    ..||||||| |||| .. | . ..         .|.  . .    |. || .|| ||  ||||| |...|| |.| | 
dliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2689-2773 1.2e-14 48.5 In-house 33-116 (332) alignment 
Range on Protein: 2689-2773
Range on HMM: 33-116/332.0
ANKDKNRLHNALPYDHNRVKLTkiPGEIGSDYINASFIDGYKAKNCYIAAQAP-KDNTLNDFWKMICEQQVSVIVMLANTEEKEQF
 | | ||.     .||.||.|.  | .   |. |||..|||  |..|| |||| .| |   ||.|. |.. |.|... . .||.. 
nnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
fn3 Fibronectin type III domain 2009-2102 3.7e-14 45.8 Pfam-A 2-85 (85) alignment 
Range on Protein: 2009-2102
Range on HMM: 2-85/85.0
VPLNLQVVGEpGRTNITIQWMIPAFPNGIITSYNVYYQPFKANSggedpsfnsSERSVTVQAISLSTTLLDLYPNSTYTISVTAINGAGESQRS
 | ||.| .  . |..|..|  |. ..| ||.|.| |..   ..          ....|| . . | || .| |...|...|.|.|||||...|
aPenlsvsev.tstsltlsWsppkdgggpitgYeveyrekggge.........ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2402-2490 6.2e-14 46.1 In-house 50-155 (349) alignment 
Range on Protein: 2402-2490
Range on HMM: 50-155/349.0
LRNRYANIQCYDHSRVKLTPVEDS---------------PHDYINANFIH--GYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKMRVKC
 .||| .|  |.||||||     |               ..||||||...   .. .. .|||| ||| |. ||....   . . |. |.. .|.   ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

TQYWPD
 .|| .
diywqe
fn3 Fibronectin type III domain 1803-1893 5e-13 42.2 Pfam-A 1-83 (85) alignment 
Range on Protein: 1803-1893
Range on HMM: 1-83/85.0
SPPFNCTALPTnSSTSISLAWSVPLQPNGLITSYSITYLPLSSTSereygaeSNSTISTPTNGTSFIVDNLYKASLYSFSLQAFTVIGGSP
|.| | .. .. .|||..| || | ...| ||.|...| . ....          ....| . ||... .|   . |.|..|| .  |..|
saPenlsvsev.tstsltlsWsppkdgggpitgYeveyrekggge.......ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
I-set Immunoglobulin I-set domain 832-923 9e-13 39.8 Pfam-A 5-90 (90) alignment 
Range on Protein: 832-923
Range on HMM: 5-90/90.0
RAPMDRTVTEFSSISLYCTVSGYERPTISWTFSNTLLSNGSNGVIIQEMtngsyeLTSVITLTNANRLDAGTYQCTGSNPLNNVTAEALLTV
. . | .|.| .|..| |||.| . |..||.  .. |.. ..  . .|        .. .|..|... |.|.|.|. .| . ...|.| |.|
qklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee......aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
fn3 Fibronectin type III domain 1691-1777 1.4e-12 40.7 Pfam-A 1-79 (85) alignment 
Range on Protein: 1691-1777
Range on HMM: 1-79/85.0
DPPTDVIVTSYTSRTIDVSWSPGFDGNNPIKGYFL-YQKDLDRDgdfilalpsTTHSYTTESGTNFRISDGIIPYTKYTFTVVACNGV
..|... |.. ||... .|||| .||. ||.|| . |... . .          ....|... |.  .  |. |.|.|.|.| |.||.
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.........ewkeftvprtttsvtltgLkpgteYefrVqavnga
I-set Immunoglobulin I-set domain 1130-1220 1.5e-12 39.1 Pfam-A 1-79 (90) alignment 
Range on Protein: 1130-1220
Range on HMM: 1-79/90.0
PVIISPPSDTTVTHPDPFSFTCVTTGHPRPNITWYKVTEGTNGatesvmaDDRTSITNTQsgdreLTSSIRVTGAIPFDAGVYTCEATNVV
|..  ...|..|.  .  ...| ..|.| |...|.|  . ..        ..| ..|...      ....... . . |.| |||.||| .
pkftqklkdvevseGesvelectveGepepsvsWakdgselks.......sqrvkvtvee.....aeytLtIsnvevsDeGkYtckatnsa
I-set Immunoglobulin I-set domain 424-516 1.7e-12 39.0 Pfam-A 4-90 (90) alignment 
Range on Protein: 424-516
Range on HMM: 4-90/90.0
LTAPMDQTVTEFSSISLYCTVSGYERPTISWTFSNTLLSNgtdgviI------QEMmngnyeLTSNITLTNVDRSSAGTYQCTGSNPLNDVTANALLTV
 . . |..|.| .|..| |||.| . |..||.  .. |..             .|        .. .|..||..| .|.|.|. .| .  ..|.| |.|
tqklkdvevseGesvelectveGepepsvsWakdgselks......sqrvkvtvee......aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2699-2839 1.8e-12 41.7 In-house 2-125 (130) alignment 
Range on Protein: 2699-2839
Range on HMM: 2-125/130.0
ALPYDHNRVKltkipgeiGSDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEqfvmsaQYWPYkrGEELAFGSASVTLQ
||... .|..        | .||||||.      . |. .|.|  .|  |||||. |. | |.|.|   ||..      .|||    | | .    ... 
alefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed......eywpd..sePlewyeediivt

LTNHQE-DYIHRQlrVTYTPRDTPPETRVVHHFSFTSWPRSG
||...| ..|. .       .|     . .  |  . ||  |
ltdrdefknikas..nleiesdlneshqaltmfqisnwpsdg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2392-2483 2.7e-12 40.8 In-house 28-117 (332) alignment 
Range on Protein: 2392-2483
Range on HMM: 28-117/332.0
VDVCLNPMNklRNRYANIQCYDHSRVKLTPvEDSPHDYINANFIHGYNRDNEFIATQGPLPDTI-GDFWRMVWDYESPTVVMLTNLQEKMRVK
 |  || |.   ||   . |.|||||.|.| .|   |. ||... ||.. . .| .| |. |     ||||| . .   .... ...|| . |
ydkflnnmd..mnriphlycfdhsrvelap.qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
I-set Immunoglobulin I-set domain 619-718 6.4e-12 37.1 Pfam-A 2-90 (90) alignment 
Range on Protein: 619-718
Range on HMM: 2-90/90.0
TVISQSPTYTVDENSTIIFQCTGTGVPEPNIAWYRNGALITDSRFTEMTDPAslnsssliysVNGSLTLTNAYDTDTDTgYSCSANNTASTVSDSFGLTV
..  ..   .| |.... ..|| .|.|||.. |...|  .. |.  ..|              . .||..|.   |... |.| |.| | ... .. |.|
kftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee..........aeytLtIsnvevsDeGk.YtckatnsagkaeakaeLkV
subfamily_CG42327_pd Subfamily CG42327 2565-2632 7.5e-12 39.5 In-house 244-312 (319) alignment 
Range on Protein: 2565-2632
Range on HMM: 244-312/319.0
YTDKRPMIIHCSAGVGRTGTFITIDSEMQRADQE-RELNPYQFVRQMRENRNHMVQTEAQFVFIHDALV
  .. |...||| ||||||. |. | .... ..  | ..  | | ..|..| . |.|  |. ||.  | 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2680-2800 8.7e-12 39.0 In-house 38-168 (349) alignment 
Range on Protein: 2680-2800
Range on HMM: 38-168/349.0
DDFYSARNDANKDKNRLHNALPYDHNRVKLTKIP--------------GEIGSDYINASFID--GYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVM
||.  .       ||| .. |||.| |||| | .              . .  ||||| ..    ..... ||| |||   |..||.|.|  ..| ... 
ddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvls

LANTEEKEqFVMSAQYWpykrgEELAFGSASVTLQLT
| . .|.. .    .||     .||.. .  | || .
Lnddkels.lekcdiyw.....qelsysnitvklqns
Ig_3 Immunoglobulin domain 1129-1218 1.1e-11 36.8 Pfam-A 1-75 (75) alignment 
Range on Protein: 1129-1218
Range on HMM: 1-75/75.0
APVIISPPSDTTVTHPDpFSFTCVTTGHP-RPNITWYkvtegtngatesvmaDDRTSITNTQSGDRELTSSIRVTGAIPFDAGVYTCEATN
.|||...|| |... .   ..|| ..| |  |.|.||               .. ... ... | ..  |.  .... . | |.|||.|.|
kPvisvspsptvtsggn.vtLtCsaeggpppptisWy...............ietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2402-2471 2.1e-11 37.9 In-house 39-114 (347) alignment 
Range on Protein: 2402-2471
Range on HMM: 39-114/347.0
LRNRYANIQCYDHSRVKLTPVE------DSPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVV
 .||  . .  | .|| |.| .      | .. ||||  |.  | ..|.| || |||||. |||.||       ||
sknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
ig Immunoglobulin domain 944-1006 2.5e-11 34.8 Pfam-A 4-64 (64) alignment 
Range on Protein: 944-1006
Range on HMM: 4-64/64.0
AQFNCSA-NAIPQPTIQWIRNGTILSSNAKYTITTTNSTSTDrssTLTIFDSTPVDAGDYYCFV
. ..||. .. |.....|...|. | .. |   ........    .||| . |. |.|.|.| |
vtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe...vLtinnvtkedsGtYtCvv
I-set Immunoglobulin I-set domain 726-824 3e-11 35.0 Pfam-A 5-90 (90) alignment 
Range on Protein: 726-824
Range on HMM: 5-90/90.0
TGPTDLTVTEFSNATFSCTVSGYERPSIEWSFMEQSSNApfsslsnnangaiIKEM-----TsgsyeLTSTLTLTNISELAAGVYRCTGSNPLANISAEA
. ..|..|.| ......|||.| . ||..|   ... .               ...            ..|||..|...  .| |.|. .| . . .|.|
qklkdvevseGesvelectveGepepsvsWakdgselks.............sqrvkvtvee.....aeytLtIsnvevsDeGkYtckatnsagkaeaka

TLTV
.|.|
eLkV
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 2684-2774 3.1e-11 36.5 In-house 21-84 (169) alignment 
Range on Protein: 2684-2774
Range on HMM: 21-84/169.0
SARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINAsfidgykakncyiaaqapkdntlndfwKMICEQQVSVIVMLANTEEKEQFV
 |   .|. |||    |   | |||| ..  ..|||||||                           .|| | . ||||.| .|..|..| 
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfw
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 2684-2774 3.8e-11 36.1 In-house 20-83 (169) alignment 
Range on Protein: 2684-2774
Range on HMM: 20-83/169.0
SARNDANKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINAsfidgykakncyiaaqapkdntlndfwKMICEQQVSVIVMLANTEEKEQFV
 |   .|. |||    |   | |||| ..  ..|||||||                           .|| | . ||||.| .|..|..| 
maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfw
Ig_2 Immunoglobulin domain 1031-1122 5.2e-11 34.4 Pfam-A 6-76 (80) alignment 
Range on Protein: 1031-1122
Range on HMM: 6-76/80.0
MTTYTVNENSTVTFQCTGTGVPEPGITWYRNGNELSTSSRItinsgspiqdgstliyqvsgslEISPVADNDSDTTYNCTASNTA-GRATDQF
 .  .|.|...||. |. .| |.| ..||..|.|||.| ..                       ..| .  .   || |.|||.  .  .. .
apptvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna......................lfipnvsaedsGtYtCrasnsegskqsnsv
I-set Immunoglobulin I-set domain 1465-1567 6.5e-11 33.9 Pfam-A 1-90 (90) alignment 
Range on Protein: 1465-1567
Range on HMM: 1-90/90.0
PYIIQRPSNATVLNGGTATFICYAVADPNHEIYWMYNSTIIANttsngyssnPSKYSIVSSRtnlqSFGSLSVQDLVFDDRGDYQCIVYNNISSLSFTAS
| . |......|  | .... | .  .|. .. |. . . ...          .....  .     .  .| ...   .| |.|.| . |.. . . .|.
pkftqklkdvevseGesvelectveGepepsvsWakdgselks.........sqrvkvtvee....aeytLtIsnvevsDeGkYtckatnsagkaeakae

LTV
|.|
LkV
ig Immunoglobulin domain 537-599 1.1e-10 32.7 Pfam-A 4-64 (64) alignment 
Range on Protein: 537-599
Range on HMM: 4-64/64.0
AQFNCSA-NAIPQPTIQWIKNGATLSSNAKYTITTTSSTSTDrssTLTILDSTPLDADDYYCSV
. ..||. .. |.....|.|.|..| .. |   ........    .||| . |. |. .|.|.|
vtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe...vLtinnvtkedsGtYtCvv
Ig_2 Immunoglobulin domain 327-416 1.4e-10 33.1 Pfam-A 9-79 (80) alignment 
Range on Protein: 327-416
Range on HMM: 9-79/80.0
YVVDENSTVTFQCTGTGVPEPDITWYRNGVPITDTrfselT-EsmldsssliysvngSLTlNNAYNTDTDTgYSCTATNT-FGNASDSFGLA
 ||.|...||. |. .| |.|...||..|.... .     . .              ... .|.  .| .| |.|.|.|.  .. |.|. ..
tvvtegenvtLtCqapgnptpkvqwykdgeelsqs.....qna..............lfi.pnvsaedsGt.YtCrasnsegskqsnsvevt
Ig_3 Immunoglobulin domain 1025-1113 1.4e-10 33.3 Pfam-A 2-75 (75) alignment 
Range on Protein: 1025-1113
Range on HMM: 2-75/75.0
PTIALQMTTYTVNENStVTFQCTGTGVP-EPGITWYrngnelstssritiNSGSPIQDGSTLIYQVSGSLEISPVADNDSDTtYNCTASN
|.| ..  ...... . ||..|. .| | .| |.||              ....|. .||   ......| ||.|  .|| | | |.|||
Pvisvspsptvtsggn.vtLtCsaeggpppptisWy..............ietppelqgsegssssestLtissvtsedsGt.YtCvasN
Ig_2 Immunoglobulin domain 1130-1219 1.4e-10 33.1 Pfam-A 2-67 (80) alignment 
Range on Protein: 1130-1219
Range on HMM: 2-67/80.0
PVIISPPsdTTVTHPDPFSFTCVTTGHPRPNITWYKVtegtngatesvmaddRTSITNTQSGdrELTSSIRVTgaipfDAGVYTCEATNV
||. .||  |.||  ... .|| ..|.| |...|||                 . ....|..   ..... ..     |.|.|||.|.| 
pvlsapp..tvvtegenvtLtCqapgnptpkvqwykd...............geelsqsqna..lfipnvsae.....dsGtYtCrasns
Ig_2 Immunoglobulin domain 424-505 1.6e-10 32.8 Pfam-A 4-69 (80) alignment 
Range on Protein: 424-505
Range on HMM: 4-69/80.0
LTAPMdQTVTEFSSISLYCTVSGYERPTISWTFSNTLLSNGTDGviiqemmngnyeltsnITLTNVDRSSAGTYQCTGSN-PL
|.||  ..||| ... | |...| . |...|.  ...||.....                . . ||  . .|||.|..|| ..
lsapp.tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna................lfipnvsaedsGtYtCrasnseg
Ig_2 Immunoglobulin domain 1587-1677 3e-10 32.0 Pfam-A 16-71 (80) alignment 
Range on Protein: 1587-1677
Range on HMM: 16-71/80.0
STSLHCVATGYPFVSITWKKNGQNISETtPNItmtttpvslsnypvnmsildvarlgsvgelAFV-SVTRNDTANYTCVASNYLPdtnlrSY
.  |.| |.| |.....|.|.|. .|.. .|.                               |. .|. .|  .|||.|||.       | 
nvtLtCqapgnptpkvqwykdgeelsqs.qna..............................lfipnvsaedsGtYtCrasnseg.....sk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 2399-2449 3.4e-10 34.0 In-house 47-95 (95) alignment 
Range on Protein: 2399-2449
Range on HMM: 47-95/95.0
MNKLRNRYANIQCYDHSRVKLTPVEDSphDYINANFIHGYNRDNEFIATQG
 |  .||. ||  || .|| ||   ||  ||||| |. || | | .||.||
anipknrflnifpydatrvvlttkrds..dyinacfvdgyarkncyiaaqg
V-set Immunoglobulin V-set domain 1469-1569 3.6e-10 30.7 Pfam-A 6-114 (114) alignment 
Range on Protein: 1469-1569
Range on HMM: 6-114/114.0
QRPSNATVLNGGTATFICYAV-ADPNHEIYWMYNST------IIANTTSNGYSSNPSKYS--IVSSRTNLQSFGSLSVQDLVFDDRGDYQCIVYNNiSSL
| |.  ||  ||..|. |.    . ...|||.  .|      ||........|. ....|     |... .|  ||..|.|  .| | |.| |... .  
qsprpvtvaeGgsvtLpCfysssensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsds.ned

SFTASLTVHV
.| |. ...|
vfgagtrltV
Ig_2 Immunoglobulin domain 619-718 6.2e-10 31.0 Pfam-A 2-80 (80) alignment 
Range on Protein: 619-718
Range on HMM: 2-80/80.0
TVISQSPTYtVDENSTIIFQCTGTGVPEPNIAWYRNGALITDSRFTemtdpaslnsssliysvngsL-TlTNAYDTDTDTgYSCSANNT-ASTVSDSFGL
.|.| .||. |.|.... . |. .| |.|.. ||..|.... |. .                    | .  |.  .| .| |.|.| |.  |..|.|. .
pvlsapptv.vtegenvtLtCqapgnptpkvqwykdgeelsqsqna....................lfi.pnvsaedsGt.YtCrasnsegskqsnsvev

TV
||
tv
Ig_3 Immunoglobulin domain 426-503 6.6e-10 31.1 Pfam-A 6-75 (75) alignment 
Range on Protein: 426-503
Range on HMM: 6-75/75.0
APMDQTVTEFSSISLYCTVSGYE-RPTISWTfsntllsngTDGVIIQEMMNGNYELTSNITLTNVDRSSAGTYQCTGSN
..  .|||.  ...| |.. |.   |||||.          ..  . .  .|...  |  |...|...  |||.|..||
vspsptvtsggnvtLtCsaeggpppptisWy.........ietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2531-2633 8e-10 32.6 In-house 219-342 (349) alignment 
Range on Protein: 2531-2633
Range on HMM: 219-342/349.0
SIKQFHYTSWPDFGVPRHPTPLIQFIHT---------VRRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEMQ-RADQERE----------LNP-YQFVRQ
 . |. .  |.| ..   |  ..| ..           | . .  .  ....||||| ||||...|.|. ..     ..|           .. .  | .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

MRENRNHMVQTEAQFVFIHDALVE
.|  |  |||  |||..|..||..
lrkqrismvqnlaqfiaiyealLk
Ig_2 Immunoglobulin domain 831-918 8.3e-10 30.6 Pfam-A 4-75 (80) alignment 
Range on Protein: 831-918
Range on HMM: 4-75/80.0
LRAPMdRTVTEFSSISLYCTVSGYERPTISWTFSNTLLSNGSNGviiqemtngsyeltsvI-TlTNANRLDAGTYQCTGSN-PLNNVTAE
|.||   .||| ... | |...| . |...|.  ...||.. |.                . .  |..  |.|||.|..|| .. ...  
lsapp.tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna................lfi.pnvsaedsGtYtCrasnsegskqsns
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 2738-2930 1.1e-09 31.3 In-house 120-309 (346) alignment 
Range on Protein: 2738-2930
Range on HMM: 120-309/346.0
AQAP---KDNTLNDFWKMICEQQVSVIVMLAnTEEKEQFVMSAQYwPYKRGEELAFGSASVTLQLTNHQEDYIHRQLRVTYTPRDTPPETRvVHHFsfTS
|| |   ..  ..||| || ..|. .. ..   ..| .   .. .   . |     |   .  . ..   |     . |           . |||   . 
aqlpqmenesfvedfwymiyqeqihlvylmv.pddklkntttslf.ndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicq.vhhh..ap

WPRSGAPSNGSGMIDLIDQVQKRqQQTGNKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDYA
|     | .   .| .| |     .|  |  . |    | ||. .|     ||...      ||..|.| .. ||   |. . ||  ||  ..|| 
wkhlqqppktlpiikmihqflse.kqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2727-2796 1.2e-09 32.0 In-house 230-294 (440) alignment 
Range on Protein: 2727-2796
Range on HMM: 230-294/440.0
DGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEKEqfvmSAQYWPYKRgEELAFGSASVT
.||  ||..||.| | | |. |||... . ..| |.|| . ..|      . ||| .    ..||  .| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt....csiywpvnt.rsvtfgpftvg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2568-2633 1.6e-09 32.1 In-house 228-293 (297) alignment 
Range on Protein: 2568-2633
Range on HMM: 228-293/297.0
KRPMIIHCSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHDALVE
. ....||||||||.|  .  |  ...  ..|  .   .....||.|  .|||  || ...|| ..
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2412-2544 2.5e-09 31.5 In-house 5-125 (130) alignment 
Range on Protein: 2412-2544
Range on HMM: 5-125/130.0
YDHSRVKltpvedsPHDYINANFIHGYNRDNEFIATQGPLPDTIGDFWRMVWDYESPTVVMLTNLQEKmrvkcTQYWPDTVGRSERFGPISVTFIKSTSH
.. ||..        ..||||.|.   .| .|.. || || ||  |||.|. .     .|.|  ..|.      .||||.         | ||  .    
fevsrlq.......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdef

ADYCIREFEIQTQDEKTTRSIKQFHYTSWPDFG
      ..||. .  .. ...  |. . ||  |
knikasnleiesdlneshqaltmfqisnwpsdg
Ig_3 Immunoglobulin domain 618-705 2.6e-09 29.2 Pfam-A 2-75 (75) alignment 
Range on Protein: 618-705
Range on HMM: 2-75/75.0
PTVISQSPTYTVDENStIIFQCTGTGVP-EPNIAWYrngalitdsrfteMTDPASLNSSSLIYSVNGSLTLTNAYDTDTDTgYSCSANN
|........... . . . ..|. .| | .|.| ||             .  | .|..|   .|....||....   |. | |.| |.|
Pvisvspsptvtsggn.vtLtCsaeggpppptisWy.............ietppelqgsegssssestLtissvtsedsGt.YtCvasN
I-set Immunoglobulin I-set domain 1575-1668 5.8e-09 27.6 Pfam-A 5-78 (90) alignment 
Range on Protein: 1575-1668
Range on HMM: 5-78/90.0
TISNSLSLLIENSTSLHCVATGYPFVSITWKKNGQNISEttpnitmtttpvslsnypvnMSILDVARLGSVGELAFVSVTRNDTANYTCVASNY
......   ...| .| | ..| |  |..|.|.|.....                     . . |   ..  .| . .|...|. .|||.|.| 
qklkdvevseGesvelectveGepepsvsWakdgselks....................sqrvkvtveeaeytLtIsnvevsDeGkYtckatns
0038934 (Phosphotyrosine protein) phosphatases II 2814-2924 1.1e-08 30.5 In-house 69-171 (194) alignment 
Range on Protein: 2814-2924
Range on HMM: 69-171/194.0
TYTPRDTPPETRVVHHFSFtswPRSGAPSNGSGMIDLIDQVQKRQQQTGNKPILVHCSAGIGRTGAFCALSIaierVKVEHIvNIYNIVKHLRTQRAHMV
.| |.. .     .... |   |  |.. . . . . .| |..  ..  .. ..||| ||.|||| ..|  .    ... .. .    ....|  | ...
yYdpeefekagieylklpf...pddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL....iyrlgm.saeeAialfrekRpgai

QNLDQYVFIYR
.| |..  ...
pnqdyleallk
C2-set_2 CD80-like C2-set immunoglobulin domain 1025-1117 1.3e-08 24.8 Pfam-A 1-86 (89) alignment 
Range on Protein: 1025-1117
Range on HMM: 1-86/89.0
PTIALQMTTYTVNeNSTVTFQC-TGTGVPEPGITWYRNGNELstssrITINSGSPiQDGSTLIYQVSGSLEISPVAdNDSDTTYNCTASNTAGR
|.|  . .. ... | .|...| .  | |.| ||||..|.||      .|.. |  || .. .. |. .|.. |    | ... .|..|. | |
peiepnesllege.neevvatCvsaggkPapritWyldgkel.....eaietsse.qdeesglvtvtstlkltpsr.edhgksltCqvsyealr
Ig_3 Immunoglobulin domain 837-910 1.5e-08 26.7 Pfam-A 10-75 (75) alignment 
Range on Protein: 837-910
Range on HMM: 10-75/75.0
RTVTEFSSISLYCTVSGYE-RPTISWTfsntllsngSNGVIIQEMTNGSYELTSVITLTNANRLDAGTYQCTGSN
 |||.  ...| |.. |.   |||||.           .  . . ..||..  |. |...... | |||.|..||
ptvtsggnvtLtCsaeggpppptisWy.........ietppelqgsegssssestLtissvtsedsGtYtCvasN
Ig_3 Immunoglobulin domain 318-404 1.7e-08 26.5 Pfam-A 2-75 (75) alignment 
Range on Protein: 318-404
Range on HMM: 2-75/75.0
PTVSSQMMNYVVDENStVTFQCTGTGVP-EPDITWYrngvpitdtrfsELTESMLDSSSLIYSVNGSLTLNNAYNTDTDTgYSCTATN
|..|..  ..|. . . ||..|. .| | .| |.||            . |.. |..|   .|....||. ..   |. | |.|.|.|
Pvisvspsptvtsggn.vtLtCsaeggpppptisWy............ietppelqgsegssssestLtissvtsedsGt.YtCvasN
ig Immunoglobulin domain 1039-1111 3.7e-08 24.6 Pfam-A 1-64 (64) alignment 
Range on Protein: 1039-1111
Range on HMM: 1-64/64.0
NSTVTFQCTG-TGVPEPGITWYRNGNELSTSSRITINS-GSP--IqdgstliyqvsgSLEISPVADNdSDTTYNCTA
.|.||..|.  .| |.....||..|..| .|...   . ..                .|.|..|  .   .|| |..
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe............vLtinnvtke.dsGtYtCvv
ig Immunoglobulin domain 843-907 4e-08 24.5 Pfam-A 2-63 (64) alignment 
Range on Protein: 843-907
Range on HMM: 2-63/64.0
SSISLYCTV-SGYERPTISWTFSNTLLSNGSNGVIIQEMTNGSYeltsVITLTNANRLDAGTYQCT
||  | |.| || . ...||..... |  .. .   .  ... .    |.|..|. . |.||| |.
ssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe....vLtinnvtkedsGtYtCv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2663-2729 4.2e-08 26.9 In-house 22-86 (440) alignment 
Range on Protein: 2663-2729
Range on HMM: 22-86/440.0
TGYSHEFSRLQSERAHFDDFYSARNdaNKDKNRLHNALPYDHNRVKLTKIPGEIGSDYINASFIDGY
  .  |.| | |  ..  |  |  |  || ||| .| | |||.|| | .. |   |||||||.|.| 
rafedewsllpsglsqpsdiaslpn..nkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
Ig_3 Immunoglobulin domain 1571-1667 4.5e-08 25.2 Pfam-A 2-75 (75) alignment 
Range on Protein: 1571-1667
Range on HMM: 2-75/75.0
PIVYTISNSLSLLIENsTSLHCVATGYP-FVSITWKkngqnisettpnitmtttpvsL---------------------Snypvnmsildvarlgsvgel
|.. . ...     .|  .|.| |.|.|  ..|.|.                                           |                    
Pvisvspsptvtsggn.vtLtCsaeggpppptisWy.....................ietppelqgsegssssestLtis....................

afvSVTRNDTANYTCVASN
   |||..|. .|||||||
...svtsedsGtYtCvasN
Ig_2 Immunoglobulin domain 235-306 5.8e-08 24.7 Pfam-A 5-71 (80) alignment 
Range on Protein: 235-306
Range on HMM: 5-71/80.0
SVDQNPVLLGSTVTLECFVPdmnqLSPQLVYSWLLNGSALSlYNTSSISITLTDPEQFGNYACYVSNSFGSE
|. . .|  |..||| | .|      |. ...| ..|..|| .... . | .. .|. |.| |..||| ||.
sapptvvtegenvtLtCqap....gnptpkvqwykdgeels.qsqnalfipnvsaedsGtYtCrasnsegsk
Ig_2 Immunoglobulin domain 535-614 6.8e-08 24.4 Pfam-A 15-80 (80) alignment 
Range on Protein: 535-614
Range on HMM: 15-80/80.0
VAAQFNCSANAIPQPTIQWIKNGATLSSNAKYtitttsststdrsstLTILDSTPLDADDYYCSVTNSV-KTVTASATLTV
 .  ..|.|.. |.|..|| |.|..||.. .                | |   .. |.. | |...||  .... | ..||
envtLtCqapgnptpkvqwykdgeelsqsqna...............lfipnvsaedsGtYtCrasnsegskqsnsvevtv
subfamily_eak_pd Subfamily eak 2558-2639 7.8e-08 26.1 In-house 226-309 (332) alignment 
Range on Protein: 2558-2639
Range on HMM: 226-309/332.0
TVRRHHKYTDKRPMIIHCSAGVGRTGTFITIDSEMQRADQeRELNPYQ---FVRQMRENRNHMVQTEAQFVFIHDALVEILNTGK
|......       || .. |  |.|.|. ||  ..  |. .  | |    .. .... |.| | .. |  ||...... | . .
tlkkyihtppsfapiiqsarGsaraGvfvvidllirlidn.kkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
Ig_2 Immunoglobulin domain 731-824 9.9e-08 23.9 Pfam-A 9-80 (80) alignment 
Range on Protein: 731-824
Range on HMM: 9-80/80.0
LTVTEFSNATFSCTVSGYERPSIEWSFMeqssNAPFSSLSNNangaiikemtsgsyeltstLTLTNISELAAGVYRCTGSN-PLANISAEATLTV
 .||| .| |. |...| . |.. |.      ....|.  |.                   | . |.|.  .|.|.|..|| .. . |   ..||
tvvtegenvtLtCqapgnptpkvqwykd....geelsqsqna...................lfipnvsaedsGtYtCrasnsegskqsnsvevtv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2685-2770 1.1e-07 25.7 In-house 32-122 (347) alignment 
Range on Protein: 2685-2770
Range on HMM: 32-122/347.0
ARNDANKDKNRLHNALPYDHNRVKLTKIPGEIG-----SDYINASFIDGYKAKNCYIAAQAPKDNTLNDFWKMICEQQVSVIVMLANTEEK
.  . . .||| ..    |  || |.    . .       ||||| |   .|.. || .| |  .|. |||||.   .|. .| . .  . 
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd
Ig_2 Immunoglobulin domain 1247-1337 1.3e-07 23.5 Pfam-A 10-68 (80) alignment 
Range on Protein: 1247-1337
Range on HMM: 10-68/80.0
YVNESSSISILCSATGLPSPSITWYRNtvqltgvsdgqfnningrisisesliqefvtaDGVINQ-TNQTLTLMANrSDTNDNYTCRADNVG
.|.|.... . |.|.| | |...||..                                .  ..| .|. ..  ..  .....||||| | .
vvtegenvtLtCqapgnptpkvqwykd................................geelsqsqnalfipnvs.aedsGtYtCrasnse
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2394-2437 1.9e-07 24.8 In-house 41-85 (440) alignment 
Range on Protein: 2394-2437
Range on HMM: 41-85/440.0
VCLNPMNKLRNRYANIQCYDHSRVKLTPVEDSP-HDYINANFIHG
..  | ||..||| || .|||||| |  |.  |  ||||| .| |
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 2399-2557 2.4e-07 23.7 In-house 25-165 (169) alignment 
Range on Protein: 2399-2557
Range on HMM: 25-165/169.0
MNKLRNRYANIQCYDHSRVKLTPV-EDSPHDYINANFIHGYNrdNEFIATQGPLpDTIGDFWRMVWDYES-PTVVMLTNLQEKMRVKCTQYWPDTVGRSE
 |. .|| |   .  | ||||  | ||   |||||..|   |     |   |   |   .||    ||.  |.|..     . . |.  .  |.| |   
cnetknrpagplapshtrvklqrvmedlgsdyinarmiwetn..asvivvlGdt.ddknnfwpekedyqlhpavilGewytdslyvrtdkvhpntsgveg

RFgpiSVTFIkstshadycIREFeiqtqDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIH
 |    |...         | ..     |.. |. .. .||..||. |||. |  . ...|
lf...evslv.........ihsy.....dddvteqlsllhystwpqngvpqspvhvghlfh
subfamily_PTPDC1_pd Subfamily PTPDC1 2534-2629 2.5e-07 25.3 In-house 84-170 (182) alignment 
Range on Protein: 2534-2629
Range on HMM: 84-170/182.0
QFHYTSWPDFGVPRhptpLIQFIHTVRRHHKYTDKRPMIIHCSAGVGRTGTFITIdsEMQRAdqeRELNPYQFVRQMRENRNHMVQTEAQFVFIHD
 ..  .|.|.||.     | . .  |.  .   ..  . .|| || ||||  |.    .  |   ..|.. . .. .|..| . .||  |  ....
yvynfgwkDygvas....leriLdivkvvafalqegkvavhChaGlGrtGvliac..ylvya...krltaekaiklvrskrpksiqtreqvelvke
I-set Immunoglobulin I-set domain 1248-1345 2.7e-07 22.3 Pfam-A 12-86 (90) alignment 
Range on Protein: 1248-1345
Range on HMM: 12-86/90.0
VNESSSISILCSATGLPSPSITWYRNTVQLTGvsdgqfnningrisisesliqefvT--------AdgvinqTNQTLTLMANRSDTNDNYTCRADNVgQD
|.| .|... |...| | ||..|...  .|.                         .                ..|||.   ... ...|||.| |    
vseGesvelectveGepepsvsWakdgselks........................sqrvkvtvee......aeytLtIsnvevsDeGkYtckatns.ag

LVTFEI
 .. ..
kaeaka
ig Immunoglobulin domain 737-808 3.2e-07 21.6 Pfam-A 2-63 (64) alignment 
Range on Protein: 737-808
Range on HMM: 2-63/64.0
SNATFSCTV-SGYERPSIEWSFMEQSSNAPFSSLSNNANGAIIKemtsgsyeltsTLTLTNISELAAGVYRCT
|..|..|.| || . ... |..  .... .  . .   .. ...           .||..| ..  .|.|.|.
ssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe...........vLtinnvtkedsGtYtCv
C2-set_2 CD80-like C2-set immunoglobulin domain 537-587 4.2e-07 19.9 Pfam-A 17-68 (89) alignment 
Range on Protein: 537-587
Range on HMM: 17-68/89.0
AQFNC-SANAIPQPTIQWIKNGATLssnakytITTTSSTSTDR-------SSTLTILDS
  ..| ||.. |.|.|.|...| .|        . ..|...|        .|||..  |
vvatCvsaggkPapritWyldgkel.......eaietsseqdeesglvtvtstlkltps
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 2399-2557 5.5e-07 22.7 In-house 26-166 (169) alignment 
Range on Protein: 2399-2557
Range on HMM: 26-166/169.0
MNKLRNRYANIQCYDHSRVKLTPV-EDSPHDYINAnfihgynrdnefiatqgplpdtigdfwRMVWDYESPTVVMLTNLQEKMRVK----CTQYWPDTVG
 |. .|| |   .  | ||||  | ||   |||||                           ||.|. ..  .|.| . ..|          |  |  . 
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil

RSERFGPISVTFIKSTSHADYCIREF----EIQTQDEKTTRSIKQFHYTSWPDFGVPRHPTPLIQFIH
       . |   | .. ..     |     |.  |.. |  .. .||..||. |||. |  . ...|
gewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvghlfh
C2-set_2 CD80-like C2-set immunoglobulin domain 332-376 5.7e-07 19.5 Pfam-A 14-63 (89) alignment 
Range on Protein: 332-376
Range on HMM: 14-63/89.0
NSTVTFQC-TGTGVPEPDITWYRNGVPI----TDTRFSELTESMLDSSSL
| .|...| .  | |.|.||||..| ..    | .. .| .. .  .|.|
neevvatCvsaggkPapritWyldgkeleaietsseqdeesglvtvtstl
Ig_2 Immunoglobulin domain 942-1023 6.4e-07 21.3 Pfam-A 15-80 (80) alignment 
Range on Protein: 942-1023
Range on HMM: 15-80/80.0
LQAQFNCSANAIPQPTIQWIRNGTILSsnakytiTTTNStstdrsstLTIFDSTPVDAGDYYCFVNNNVkTVNVSATLTVHV
 .  ..|.|.. |.|..|| ..|..||       ...|         | |   .. |.| | | . |   . ..| ...|.|
envtLtCqapgnptpkvqwykdgeels.......qsqna........lfipnvsaedsGtYtCrasnse.gskqsnsvevtv
ig Immunoglobulin domain 1586-1665 6.9e-07 20.5 Pfam-A 2-64 (64) alignment 
Range on Protein: 1586-1665
Range on HMM: 2-64/64.0
NSTSLHCVA-TGYPFVSITWKKNGQNISETTPNITMTTTPVSLSnypvnmsildvarlgsvgELAFVSVTRNDTANYTCVA
.|. | | . .| |.....|.|.|.   | ..  . ..  .. .                   | . .||..|  .||||.
ssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe..................vLtinnvtkedsGtYtCvv
0038934 (Phosphotyrosine protein) phosphatases II 2534-2588 8.4e-07 24.3 In-house 81-135 (194) alignment 
Range on Protein: 2534-2588
Range on HMM: 81-135/194.0
QFHYTSWPDFGVPRHPTPLIQFIHTVRRHHKYTDKRPMIIHCSAGVGRTGTFITI
...   .||.|..     | .|.. | ....   .    .|| ||.|||||..  
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
Ig_3 Immunoglobulin domain 728-811 8.5e-07 21.1 Pfam-A 7-75 (75) alignment 
Range on Protein: 728-811
Range on HMM: 7-75/75.0
PTDLTVTEFSNATFSCTVSGYE-RPSIEWSfmeqssnapfsslsnnANGAIIKEMTSGSYELTSTLTLTNISELAAGVYRCTGSN
..  |||.  | |..|.. |.   |.| |.                  .  . . . ||..  ||||... ..   |.|.|..||
spsptvtsggnvtLtCsaeggpppptisWy................ietppelqgsegssssestLtissvtsedsGtYtCvasN
ig Immunoglobulin domain 436-500 1e-06 20.0 Pfam-A 2-63 (64) alignment 
Range on Protein: 436-500
Range on HMM: 2-63/64.0
SSISLYCTV-SGYERPTISWTFSNTLLSNGTDGVIIQEMMNGNYeltsNITLTNVDRSSAGTYQCT
||  | |.| || . ...||..... |  .. .   .   ....     .|..|| .. .||| |.
ssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe....vLtinnvtkedsGtYtCv
C2-set_2 CD80-like C2-set immunoglobulin domain 1134-1190 1e-06 18.7 Pfam-A 4-61 (89) alignment 
Range on Protein: 1134-1190
Range on HMM: 4-61/89.0
SPPSdTTVTHP-DPFSFTC-VTTGHPRPNITWYKVTEGTNGATESVMADDRTSITNTQS
.|.  ......     .|| .. |.|.|.||||.  ........|.  |. . .....|
epne.sllegeneevvatCvsaggkPapritWyldgkeleaietsseqdeesglvtvts
Rifin_STEVOR Rifin/stevor family 2257-2318 1.2e-06 19.1 Pfam-A 224-283 (299) alignment 
Range on Protein: 2257-2318
Range on HMM: 224-283/299.0
NKKQSTSAERQYTEFTSSNYTAVVTT-ATNPGPAIAGSVVtvlLVIIIIVVVVIVVLFLVYRK
 .|  . || . ||  ... ||....   .   || .||.   ...||..|..|. | | || 
aakaakkaeedvteaikkketalieskfaslttaIiasvi...ailiIvlvmlIIylilrYRR
subfamily_ptpA1_pd Subfamily ptpA1 2896-2929 1.3e-06 22.4 In-house 364-397 (418) alignment 
Range on Protein: 2896-2929
Range on HMM: 364-397/418.0
VNIYNIVKHLRTQRAHMVQNLDQYVFIYRAILDY
.|...|| .|| ||  |||.|.||.| |..||| 
fnlfsivlklreqrpgmvqqleqylfcyktilde
C2-set_2 CD80-like C2-set immunoglobulin domain 624-674 2.9e-06 17.2 Pfam-A 6-59 (89) alignment 
Range on Protein: 624-674
Range on HMM: 6-59/89.0
SPT-YTVDeNSTIIFQC-TGTGVPEPNIAWYRNGALITDSR--FTEMTDPASLNS
...  ... | . ...| .  | |.|.| ||..|  ....    ......  ...
nesllege.neevvatCvsaggkPapritWyldgkeleaietsseqdeesglvtv
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 2455-2629 2.9e-06 20.1 In-house 131-303 (346) alignment 
Range on Protein: 2455-2629
Range on HMM: 131-303/346.0
IGDFWRMVWDyESPTVVMLTNLQEKMRVKCTQYWPDTVGRSERFGPISVTFIKSTSHADYciREFEIQTQDEKTTRSI--KQFHYTSWPDFGVPRHPTPL
. ||| |... |   .| |   ..|..   |  . |  |  .  | . .   ..    |   .|. |.   |  . |.  .  |.. |  .  | .  |.
vedfwymiyq.eqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdp..keytievlpegnsdsvicqvhhhapwkhlqqppktlpi

IQFIHTVRRHHKYtDKRPMIIHCSAGVGRTGTFITIDSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFIHD
|..||     ..   .  . .    | ||. .||     ... ..  | | .. .......|   |.. ||.  |. 
ikmihqflsekqv.qnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiya
Ig_3 Immunoglobulin domain 1250-1335 3.7e-06 19.1 Pfam-A 14-75 (75) alignment 
Range on Protein: 1250-1335
Range on HMM: 14-75/75.0
ESSSISILCSATGLP-SPSITWYrntvqltGVSDGQFNNINGRISISESLIQEFVTadgvinqtnqtltlmanrSDTNDNYTCRADN
.. .... |||.| | .|.|.||          ...... .|. |.. .|  ..||                  |. . .||| | |
sggnvtLtCsaeggpppptisWy.......ietppelqgsegssssestLtissvt..................sedsGtYtCvasN
subfamily_PTEN_pd Subfamily PTEN 2552-2627 4.7e-06 21.7 In-house 98-172 (184) alignment 
Range on Protein: 2552-2627
Range on HMM: 98-172/184.0
LIQFIHTVRRHHKYTDKRPMIIHCSAGVGRTGTFITIdSEMQRADQERELNPYQFVRQMRENRNHMVQTEAQFVFI
| ......... .  .|. ...|| || ||||. |.    ...   |.. .  ..  ..| . .. |.  .|  ..
leeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYv
Ig_3 Immunoglobulin domain 238-301 4.8e-06 18.7 Pfam-A 8-75 (75) alignment 
Range on Protein: 238-301
Range on HMM: 8-75/75.0
QNPVLLGST-VTLECFVPDMNQlspQLVYSWL------LNGSALSLYNTSSISITLTDPEQFGNYACYVSN
..|.  ... ||| | ...         .||.      |.||  | .. |. .|. ...|. |.| |..||
psptvtsggnvtLtCsaeggpp...pptisWyietppelqgsegssssestLtissvtsedsGtYtCvasN
C2-set_2 CD80-like C2-set immunoglobulin domain 942-994 5.1e-06 16.4 Pfam-A 15-68 (89) alignment 
Range on Protein: 942-994
Range on HMM: 15-68/89.0
LQAQFNC-SANAIPQPTIQWIRNGTILSSNAKYTITTTNSTSTDRSSTLTIFDS
 .  ..| ||.. |.|.|.|...|  |.  .  . . ..|. .  .|||..  |
eevvatCvsaggkPapritWyldgkeleaietsseqdeesglvtvtstlkltps
V-set Immunoglobulin V-set domain 1033-1120 5.9e-06 17.1 Pfam-A 10-104 (114) alignment 
Range on Protein: 1033-1120
Range on HMM: 10-104/114.0
TYTVNENSTVTFQCTGT-GVPEPGITWYRnGNELSTSSRIT-------INSGSPIQDGSTLIYQVSG----SLEISPVADNDSDtTYNCTASNTagrATD
  ||.|. .||..|. .    .  |.||. ... |.. .|.        .. ..  .|.. ... ..    || |. .  .||  ||.|..|..    .|
pvtvaeGgsvtLpCfysssensqsiyWyk.qktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsG.tYtCavsds...ned
Y_phosphatase3 Tyrosine phosphatase family 2859-2900 8.5e-06 20.9 Pfam-A 121-161 (164) alignment 
Range on Protein: 2859-2900
Range on HMM: 121-161/164.0
QQTGnKPILVHCSAGIGRTGAFCALSIAIERVKVEHIVNIYN
...  .|.|.||.||  ||| ..||  ..  |. | |.. | 
aeee.gpvlfHCtaGKDRTGvvaalllsllgvdeetiaaDYl
V-set Immunoglobulin V-set domain 1136-1219 8.8e-06 16.5 Pfam-A 8-101 (114) alignment 
Range on Protein: 1136-1219
Range on HMM: 8-101/114.0
PSDTTVTHPDPFSFTCVTT-GHPRPNITWYKVTEgtnGATESVMA-----DDRTSITNTQSGDRELTS-------SIRVTGAIPFDAGVYTCEATNV
|.  || . .  ...|  .  .   .|.||| ..   | ..  ..     ..... ..  ||...|.|       |....   . | |.|||.... 
prpvtvaeGgsvtLpCfysssensqsiyWykqkt...gskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsds