Gene PTPRD-8 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP139_AA protein Get Run
AqueP139_AA_1015-1294 phosphatase_domain Get Run
AqueP139_AA_1310-1581 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1309-1589 2.5e-154 507.4 In-house 7-287 (287) alignment 
Range on Protein: 1309-1589
Range on HMM: 7-287/287.0
FNRMSKPDTKTGRTGFIDQFTVLEQVTQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
|..... ....|..|| .|||||||||||.|||||||||||.||||.||.|..|||||.||||||||||||||.||||||||||||||||||||||||.|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkli

DDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSgLVIGEYAIMLSSEEIYNGYIERKLEVKNTN-TGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKT
||||||||||||.||| |.||||||||.. | .|.|||.|.| .||...|||||||||||.| .|..|.|.||||||| ||.|...||||| ||||||||
ddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

QRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSNF
||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||..|..|||.|||||||||.|
qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1012-1302 4e-135 444.4 In-house 1-287 (287) alignment 
Range on Protein: 1012-1302
Range on HMM: 1-287/287.0
LIPVGQFGEFVANGHAKGNEGFKNQYCTLNS-GDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNqipgntDCQNDYINACYIDGYSQDYKYIATQGP
||||..||||||.||||||||||||...|.. ...|..||......|...||. .|.|.|..|.||.      ....|||||..||||......|....|
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

VTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHG-VPEYAT
...|...||.||.......|||....||... .|.|||||. |...|...|||..|.| ..|..||....  ..........||..|.|...| |.|..|
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

SILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDS
..|......|...|.......||||..|||...|.|..........||.||........|.|....|||..||.|.||.|||......|..|.
illvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1012-1298 2.6e-129 425.2 In-house 1-288 (290) alignment 
Range on Protein: 1012-1298
Range on HMM: 1-288/290.0
LIPVGQFGEFVANGHAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTDCQNDYINACYIDGYSQDYKYIATQGPV
||||..||||||||||||||||.||. .|.||..||.||...|.||..|||| |||||||||| |..|.|. ||.|.|||||||.||.....||||||||
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

TKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHG-VPEYATS
..||||||.|||||. ..|||.|| .|. . ||.||||......||.|.|.|..|..|..|..||....   |.... ..|||..|.|...| |....|.
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNT
.|......|...|.......||||..|||...|.|..........||.||........|.|....|||..|| .... ||..... .|
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1315-1587 4.9e-125 411.2 In-house 13-290 (290) alignment 
Range on Protein: 1315-1587
Range on HMM: 13-290/290.0
PDTKTGRTGFIDQFTVLEQvTQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLK--GEHPD----YINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
 ....|..|| .||..|.. .... .||....|.|. .||.......|..|..|.  ..|.|    ||||..|.||||||..|....|..||...|||.|
nghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli

DDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLvIGEYAIMLSSEEIYNGYIERKLEVKNTNT-GSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKT
....||.||||....| ....|.||||....   .||. | |..||..|.||||||||||.|. |..|||.||||||| || |...|||||.||||||||
wqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemykt

QRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYS
||.||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys
subfamily_PTPRD_pd Subfamily PTPRD 1012-1372 2e-123 408.0 In-house 4-361 (564) alignment 
Range on Protein: 1012-1372
Range on HMM: 4-361/564.0
LIPVGQFGEFVANGHAKGNEGFKNQYCTLNSGdNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNtdCQNDYINACYIDGYSQDYKYIATQGPV
 ||| .. |.||. .|...  |...| ....| ...... |  | |.. ||. ||| || .|. |....|.   . ||||| .|||| .. .|||||||.
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtqgPl

TKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLtLLGSDQPPLMITQYHFTSWPDHGVPEYATSI
 .|. ||||..|...  .|||.|.|.| .. |||.||||.|...|| . ..|..|. |.||.||...|    ...   ...|.||||||||||||.|||.
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatsl

LQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNR
|.. |....  .|..||..|||||||||||||..||. |.....|. .|| ......|.||  |||| .||||. .|.|| ..||||.|.|.| .  ...
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

MSKPDTKTGRTGFIDQFTVLE-QVTQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEH
... ...|. ||.   |  |.  . . ..| .    ..|..||| .. |. .. || |. ..
LaeveedtemtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsair
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1012-1314 5.5e-103 339.3 In-house 3-304 (305) alignment 
Range on Protein: 1012-1314
Range on HMM: 3-304/305.0
LIPVGQFGEFVANGHAKGNEGFKNQYCTLNSGdnEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTdcQNDYINACYIDGYSQDYKYIATQGPV
 | . .. ... . ... ..|...|| .| .   |.|. .  .  |.  ||. .|...||.|| |.. . .   ..|||||.|.|||..  |||..|||.
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPl

TKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGST--SYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYAT
 .|..||||||..|.. .|||.|.|.|.   ||.|||||  .    .|.| .||. |.  .||..||....   .|.    ..||..|.|||||||..||
kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

SILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIV
|.|.. .|.....|  || |.||||||||||||.|.|.|. |....||. .|.  .....|..||||||| ||| |. ||. | .|||.|..   | |. 
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar

FNRMSK
 |.. |
vnklkk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1013-1328 4.4e-98 323.2 In-house 2-315 (318) alignment 
Range on Protein: 1013-1328
Range on HMM: 2-315/318.0
IPVGQFGEFVANGHAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTdcQNDYINACYIDGYSQDYKYIATQGPVT
|.| .. . |.. ...|.  ....|  |.  ... . . ...| |.  ||. ||. ||. |..|... |..  . ||||| ||||| .. .|||.|.|..
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegee..gsDyinanyidGyrrkkayiaaqaPlp

KTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSIL
.|. ||||..|.    ||||.|...| . .|.|.|||..||.|||  ..||..|  |.||..|....|  ....   .. |||.|||||.|||| ..|.|
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeee.srqvrqyhytsWpdegvpesgasll

QFHRRIKNEY-KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNR
.. |....   |...||..|||||||||||.|.|.|. |.....|. .|.  .....|.||  |||| |||.|. |..|| ...|.|.||... |   ..
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire

MSKPDTKTGRTGFIDQF
. ..|...|.| .  .|
lreqdpesgttemdaef
0051299 (Phosphotyrosine protein) phosphatases II 1011-1292 7.9e-97 319.4 In-house 3-285 (288) alignment 
Range on Protein: 1011-1292
Range on HMM: 3-285/288.0
NLIPVGQFGEFVANGHAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGntDCQNDYINACYIDGYSQDYKYIATQGP
. |.| .. ..| . .|.|. |..... .| |    .....|. | |.. ||. .|. ||..|. |. ..|  .  .||||| ||||| .. |.||||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqgP

VTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLG---SDQPPLMITQYHFTSWPDHGVPEY
  .|. ||||..|... .||||.|.| |.  .||.||||..||. ||.....|..|.|| |||.|....| |.    |. ....|..|.|.|||||||..
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

ATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLES
....|.| |.... .....||..||||||||||||| |.|. |.| |||||.|. ......|.||. |||| .||.|| .|.|| 
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1012-1327 3e-96 317.3 In-house 4-317 (319) alignment 
Range on Protein: 1012-1327
Range on HMM: 4-317/319.0
LIPVGQFGEFVANGHAKGNEGFKNQYCTLNSGDNEhSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTDcqNDYINACYIDGYSQDYKYIATQGPV
 |.| .. | . . ...|. ...... .|. ..|. ... | .. |.. ||. ||. ||  |. | ...|  .   ||||| .|||| .  |.||||.|.
eievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgveg..sdyinasfidgyqerekfiatqaPl

TKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSI
 .|. ||||..|.|.  ..||.|.|.|   .|...||||.  ..|| . ..| .|. | || |||..|  . |.    .......|.||||.|||.|||.
entiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsl

LQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFN
|.. .||..  . ...||. |||||||||||||...|. |.. ..|| .|. |.....| ||  |||. .||.|. .|.|| |..|.|... .. |  . 
ldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlk

RMSKPDTKTGRTGFIDQ
.... ...|| ||.  .
qlaekvadtgetglere
0050432 (Phosphotyrosine protein) phosphatases II 1026-1297 7.2e-95 313.1 In-house 37-303 (308) alignment 
Range on Protein: 1026-1297
Range on HMM: 37-303/308.0
HAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLnqipgntDCQNDYINACYIDGY--SQDYKYIATQGPVTKTLVDFWRLIW
.|... ... .. .|.|  . .. ..|  | |...||. .|. || .|. |       |  .||||| |.|||   .. |.||||||  .|. ||||..|
kaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

QERPPVIVMVTNLKEDTTIKCHQYWPEH---GSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKN
... .||||.|.| |.  .||.||||.    ||. ||.|...|..|.|| |||.|...|| ||...  ...|..|.|.|||||||......|.| .....
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrk

EYkpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGN
 .   .||..||||||||||||| |.|. |.| |||||.|. ....|.|.||. |||| .||.|. .|.|| . .  
sl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0040438 (Phosphotyrosine protein) phosphatases II 1017-1317 2.4e-94 311.5 In-house 4-300 (317) alignment 
Range on Protein: 1017-1317
Range on HMM: 4-300/317.0
QFGEFVANGHAKGNEGFKNQYCTLNSGDNEhSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGntDCQNDYINACYIDGYSQDYKYIATQGPVTKTLV
.. ...   ..... ........| | . . . ..|  | |...||. .|. ||..|. |. ..|  |  .||||| |.||...  |.||||||  .|. 
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntve

DFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHR
||||..|...  ||||.|.|.|.  .||.||||. ... ||.|...|..|..| ..|.|..... |  |......|..|.|.|||||||.. ...|.| .
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfle

RIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSKPD
.... ... .||.|||||||||||||| |... |.| |||||.|. ......|.||...||| .||.|. ||.|| .....| ..  .    . ..  |.
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllipl

T
.
a
subfamily_PTPRB_pd Subfamily PTPRB 1011-1294 5.2e-92 303.0 In-house 5-286 (293) alignment 
Range on Protein: 1011-1294
Range on HMM: 5-286/293.0
NLIPVGQFGEFVANGHAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIpgNTDCQNDYINACYIDGYSQDYKYIATQGP
. | . .| |.|.. .|. . .|...| .|.. .....|..| .. ||  ||. ||. || .|. |...  ... ..||||| ||.||..  ..||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaal..kdesgsDYinanyipgynsprefiatqGP

VTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEH-GSTSYGPFRIELTKEQVLTDYTIRKMQLTLlgsDQPPLMITQYHFTSWPDHGVPEYAT
. .|. ||||..|...  .|||.|.| |   .||..|||..  .. ||  ...|..|..|.|..||.....    ..    ..|||||||||||||| ..
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektk

SILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVT
..|.| |.....   . .|.|..|||||||||||||.|.|. ||. |.|  .||..|. ..|..|. .||| .||||....||. ..
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
0036941 (Phosphotyrosine protein) phosphatases II 1027-1299 4.3e-91 300.6 In-house 9-283 (297) alignment 
Range on Protein: 1027-1299
Range on HMM: 9-283/297.0
AKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLnqipgnTDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQER
.... ... .. .| .  .  | ..|  | |...||. .|. ||..|. |      .|  .|||||.|.|||....|.||||||  .|. ||||..|...
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

PPVIVMVTNLKEDTTIKCHQYWPEH--GSTSYGPFRIELTKEQV--LTDYTIRKMQLTLLGSDqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
 .||||.|.| |.  .||.||||.   .|  ||.|...|....|  |.|||.|....| .|.. .....|..|.|.||||||||...|.|.| ..... .
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvl

K--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE---KEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQ
|  | .||.||||||||||.||| |.|. ||| |   ||||.|| ....|.|.||. .||| .||.|. .|.|| . ...| 
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0046845 (Phosphotyrosine protein) phosphatases II 1033-1298 1.1e-90 299.2 In-house 2-279 (284) alignment 
Range on Protein: 1033-1298
Range on HMM: 2-279/284.0
FKNQYCTLNSGDNEH--SVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNtDCQNDYINACYIDGY-----SQDYKYIATQGPVTKTLVDFWRLIWQE
.. .. .|.|    .  |...|. | |. .||. .|..||..|. |. ..|. .  .||||| |.|||      .  |.||||||. .|. ||||..|..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RPPVIVMVTNLKEDTTIKCHQYWPEHG-STSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-
. .||||.|.| |.  .||.||||. | .  ||.|...|..|.|  |||.|...|| || .......|..|.|||||||||......|.| | ... .. 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---GIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNT
 |..||..||||||||||||| |.|. |.| ||||   |.|. ......|.||. |||| .||.|| .|.|| . ...|
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0047943 (Phosphotyrosine protein) phosphatases II 1026-1291 2.7e-89 294.6 In-house 7-270 (273) alignment 
Range on Protein: 1026-1291
Range on HMM: 7-270/273.0
HAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLnqipgnTDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQE
...|. ... .. .| |  .... ..|. | |. .||. .|. ||..|. |      .|  .||||| |.||| .  |.||||||  .|. ||||..|..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

RPPVIVMVTNLKEDTTIKCHQYWPEHG---STSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
. .||||.|.| |.  .||.||||. |   |. ||.|...|..|..  |||.|...|| ||... ....|..|.|.|||||||.. .|.|.| . ... .
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkal

KP--TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
.    .||..||||||||||||| |.|. |.| |||||.|. ......|.||. |||| .||.|. .|.||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1020-1300 8.5e-89 292.7 In-house 16-297 (298) alignment 
Range on Protein: 1020-1300
Range on HMM: 16-297/298.0
EFVANGHAKGNEGFKNQYCTLNSGDN---EHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPgnTDCQNDYINACYIDGYSQDYKYIATQGPVTKTLV
...|  ..|.  |..... .|||. .   |.. ..| .|.|.  ||. .|. .|  |..|...   .| . ||||| ....|..   .||||.|.|.|..
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetve

DFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDqPPLMITQYHFTSWPDHGVPEYATSILQFHR
||||....|   .|||.|||.|  ..|.|.|||..|.. || ....| .... .|...||....   ..    .. | |||||||.||||.|||.|.. |
dFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllr

RIKNeYKPTKG--PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQV
...  ..   |  |..|.|||||||.|||.|||  |....||  .|.  ... .|..|...||| .||.|. .|||| ....|...
kvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0043336 (Phosphotyrosine protein) phosphatases II 1014-1291 3.7e-88 290.9 In-house 3-275 (278) alignment 
Range on Protein: 1014-1291
Range on HMM: 3-275/278.0
PVGQFGEFVANGHAKGNEGFKNQYCTLNSGDNeHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTDcqNDYINACYIDGYSQDYKYIATQGPVTK
.| .. ..... ..... ...... .|.| .   . .||  | |...||. .|. || .|. |. ..|  |  .||||| |.|||..  |.|||||| ..
svkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpe

TLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPeHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQ
|. ||||..|... ..|||.|.|.|.  .||.||||  ||. ||.|...|.||..| |||.|.. .| ||.... ...|.||...||||||||  ...|.
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllld

FHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
| ..... ... .||.||||||||||||||.|... |.|.|||||.|. ......|.||...||| .||.|. .|.||
flkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPRA_pd Subfamily PTPRA 1011-1324 1e-87 289.1 In-house 12-326 (330) alignment 
Range on Protein: 1011-1324
Range on HMM: 12-326/330.0
NLIPVGQFGEFVANGHAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTDcqNDYINACYIDGYSQDYKYIATQGP
  .|| .. | .    |  |. |.... .| .|. . .. .|    |.  ||. ||. || .|. |... |. .   ||||| .|||| .  |.||.|||
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGvee..sdyinasfidGykekdkfiaaqGP

VTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSD---QPPLMITQYHFTSWPDHGVPEY
 ..|. ||||.||. .   |||.|.|||    ||.||||..|. .||  |.|. .|.|| |||.||. .. |.     ... ...|.||||||| |||  
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

ATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARI
.  .|.. ...|.  . . ||. |||||||||||||...|  |.. . |. .|.  .....|.|| .||||  || |.  ..||    |.|..|      
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslek

VFNRMSKPDTKTGRTGF
 .... .  |.| ..|.
hlqklynkitgtdkigl
subfamily_PTPRG_pd Subfamily PTPRG 1013-1306 1e-87 289.7 In-house 1-300 (563) alignment 
Range on Protein: 1013-1306
Range on HMM: 1-300/563.0
IPVGQFGEFVANGHAKGNEGFKNQYCTLNSGDNEH--SVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTDCQnDYINACYIDGYSQDYKYIATQGP
.|| .| . ||. ||.|. ||....  |.|  ...   .. .  |.|.  ||  ||| ||  |. |...||. .   ||||| ||||| .  ..||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

VTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLL----GSD-QPPLMITQYHFTSWPDHGVP
...|. ||||.||...  .|||.|||.|..  ||..|||. .|  || ... |..|.||. ||.|....  |    ... .  ....|||.|.|||||||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

EYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNA
|...  |.| .. .   | . ||..||||||||||||....|  |.| ..|  ...  .. ..| ||  .||| .||||. ||.|| .. ..|.. . . 
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

R
.
e
0039614 (Phosphotyrosine protein) phosphatases II 1014-1296 4.8e-87 287.4 In-house 15-292 (297) alignment 
Range on Protein: 1014-1296
Range on HMM: 15-292/297.0
PVGQFGEFVANGHAKGNEGFKNQYCTLNSGDNEhsVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNtDCQNDYINACYIDGYSQ-DYKYIATQGPVT
|.. .  ..   .|... ...... .| |   .   .||  | |...||. .|. ||..|. |. ..|  |  .||||| |.|||.. . |.|||||| .
plsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlp

KTLVDFWRLIWQERPPVIVMVTNLKEDTTiKCHQYWPEHGStSYGPFRIELTKEQVLTDYTIRKMQLTLlgsDQPPLMITQYHFTSWPDHGVPEYATSIL
.|. ||||..|... .||||.|.|.|.   ||.||||| |.  ||.|...|.|...| .||.|.. .|    .......|....|.|||||||......|
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslelll

QFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCG
.| . ... ..  | .||.|||||||||||||| |... |.| |||||.|. ......|.||...||| .||.|. ||.|| . ..
eflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPRK_pd Subfamily PTPRK 1030-1328 1e-86 285.6 In-house 21-312 (314) alignment 
Range on Protein: 1030-1328
Range on HMM: 21-312/314.0
NEGFKNQYCTLNSGdnehsVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGntDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPV
. |||..| .|  |        |    ||  ||.|.|. ||  |. | .| |  | ..||||| .||.| .  ..|.||||. .|. |||||...|.   
gygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencas

IVMVTNLKEDTTIKCHQYWPEHGSTsYGPFRIELTKEQVLTDYTIRKMQLTLL-GSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGP
|||.|.|.| . .|| .||||.... ||....|| . ..|... .| .... |  . .   .. |..|..||||.|| .||..|.. ||.|.  ....|.
ivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGr

MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRMSKPDTKTGRTGFIDQF
..|||||| ||||||.|||. |. .|.|| .|.  .. ..|.... ||.| .||.|. |..||.. ||.| .   . . ..  ... |..|  . . ..|
ivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeef
0045450 (Phosphotyrosine protein) phosphatases II 1012-1291 1.6e-86 286.1 In-house 8-302 (307) alignment 
Range on Protein: 1012-1291
Range on HMM: 8-302/307.0
LIPVGQFGEFVANGHAKGNEGFKNQYCTLNSGDN--EHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNtDCQNDYINACYI--------DGYSQD
.|.. ..  .|.  ......|.. .. .|.|      .. .||  | |...||. .|. ||..|. |. ..|. .  .||||| |.        ||| ..
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlk

YKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGST-SYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWP
 |.||||||  .|. ||||..|...  ||||.|.|.|.. .||.||||. |..  ||.|...|..|..| .||.|.. .| |. .......|..|.|.||
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwp

DHGVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
|||||..  ..|.| ..... .   | .||.||||||||||||||.|... |.| ||||    .|. ......|.||...||. .||.|. .|.||
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1020-1291 4.5e-85 280.2 In-house 10-277 (288) alignment 
Range on Protein: 1020-1291
Range on HMM: 10-277/288.0
EFVANGHAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPgnTDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFW
. ||. .|....||...| .| . ....|||..  . | . ||. ||. || .|. |.. .  .  ..||||| ||||. .. ||||||||...|. |||
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkle..eeagaDYinasyidgekkkkkyiatqgPladtvndfW

RLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGS-TSYGPFRIELTKEQVLTDYTIRKMQLTllgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRI
.|.....   |||.|.| |.   ||..|||. .  . || . ..|.... |.|.. ||. |     ..  | ||||....|||||||| .. .|.. | .
elvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqv

KNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
|.  .   ||..|||||||||||||.|.|. ... |.|  ||......|.|.||. .|||  ||.|. ...|.
kvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
DSPc_SM00195 1033-1292 7.1e-84 276.6 In-house 2-261 (263) alignment 
Range on Protein: 1033-1292
Range on HMM: 2-261/263.0
FKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNtdCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVM
.|... .|.. ......| |  ..|.  ||. ||..||..|. |......   ..||||| ||.|.... ||||||||  .|. ||||..|.|. ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEDTTIKCHQYWPEH--GSTSYGPFRIELTKEQVLT-DYTIRKMQLTLLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
.|. .|.  .||..||||   |.. .| ....|....    ....|...||  |  . .  .|||....|||||||. ..|.|.. | .|.... ..||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLES
.|||||||||||||..||. |.. |.|  .|| .|....|.||..|||| .||.|. .|.|| 
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1033-1292 7.1e-84 276.6 In-house 2-261 (263) alignment 
Range on Protein: 1033-1292
Range on HMM: 2-261/263.0
FKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNtdCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVM
.|... .|.. ......| |  ..|.  ||. ||..||..|. |......   ..||||| ||.|.... ||||||||  .|. ||||..|.|. ..|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

VTNLKEDTTIKCHQYWPEH--GSTSYGPFRIELTKEQVLT-DYTIRKMQLTLLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPM
.|. .|.  .||..||||   |.. .| ....|....    ....|...||  |  . .  .|||....|||||||. ..|.|.. | .|.... ..||.
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpi

LVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLES
.|||||||||||||..||. |.. |.|  .|| .|....|.||..|||| .||.|. .|.|| 
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1026-1293 4.2e-82 270.4 In-house 10-276 (281) alignment 
Range on Protein: 1026-1293
Range on HMM: 10-276/281.0
HAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTdcQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQE
... |.||...| .|.. ..... | . .. |.  ||. ||| ||  |. ...   |.  ..||||| ...||... .|||||||| ..||.||...|..
sqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk..ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

RPPVIVMVTNLKEDTTIKCHQYWPEHG-STSYGPFRIELTKEQVLTDYTIRKMQLtlLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK-NEYK
.  .|||||.  |   .|||.|||..  ...|| .... |.|.  . |  ||..|    .. ..  ..| ..|.|||||||. .. .|.|.. ..  . |
kvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltek

PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESV
 || |...|||||||||||..|.|  ....|.|   .|.  .....|..|. ||||  || ||  |||. .
ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
Y_phosphatase Protein-tyrosine phosphatase 1057-1291 5.8e-82 270.0 Pfam-A 1-235 (235) alignment 
Range on Protein: 1057-1291
Range on HMM: 1-235/235.0
NRPLNRFGNIVVYDDNRILLnqipgNTDCQ-NDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWP--EHGS
|.  ||. .|..||..|. |     . ... .||||| |..||... |.||||||. .|. ||||..|||.  ||||.|.|.|    ||.||||  |..|
nkkknRykdilpydktrvkl.....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

TSYGPFRIELT-KEQ-VLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQ
..|| ...||. ||.   ..||.||..|.  .... . ...|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
|.|.|. .|. .|....|.||..|||...||||. .|.||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1057-1291 5.8e-82 270.0 In-house 1-235 (235) alignment 
Range on Protein: 1057-1291
Range on HMM: 1-235/235.0
NRPLNRFGNIVVYDDNRILLnqipgNTDCQ-NDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWP--EHGS
|.  ||. .|..||..|. |     . ... .||||| |..||... |.||||||. .|. ||||..|||.  ||||.|.|.|    ||.||||  |..|
nkkknRykdilpydktrvkl.....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

TSYGPFRIELT-KEQ-VLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQ
..|| ...||. ||.   ..||.||..|.  .... . ...|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
|.|.|. .|. .|....|.||..|||...||||. .|.||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1028-1298 8.6e-82 269.2 In-house 12-298 (301) alignment 
Range on Protein: 1028-1298
Range on HMM: 12-298/301.0
KGNEGFKNQYCTLNSGDnEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERP
| ...|..|| .|..|. ..| |. .. .|..|||| ||.|||||||.|.. |  . ||..|||| ||||||.  |.||.|||. |||||||||||||.|
khsnkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

PVIVMVTNLKEDTTIKCHQYWPE--HGSTSYGPFRIELTKEQVLTDYTIRKMQLTLL--------------GSDQPPLMITQYHFTSWPDHGV-PEYATS
  |||||||||.|  ||.||||.  . |...||| ..|..|||. |..||......                ||. .  ..|.. |.||..|| .|..| 
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNT
.   .  |. . |. .||..||||..|.|.|.......|| |.  || .|.. ... .|......|.| .||... |.. . ... .|
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1012-1328 9.7e-81 266.1 In-house 5-314 (315) alignment 
Range on Protein: 1012-1328
Range on HMM: 5-314/315.0
LIPVGQFGEFVANGHAKGNEGFKNQYCTLNSGdNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIpgNTDCQNDYINACYIDGYSQDYKYIATQGPV
 ||. |.  .||. .|  ..|||..| ..  | . | . .|    |.  ||. ||. ||  |. |  .  ..| . ||.|| .||||..  .|||.||| 
pipldqlityvaqkkastkngfkqdyesipgg.qlhpldvakkienkqknryiniiaydksrvqlpll..endphsdyvnanfidGynkkrryiaaqgpn

TKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHgSTSYGPFRIELTKEQVLTDYTIRKMQLTlLGSDqpPLMITQYHFTSWPDHGVPEYATSI
. .. |||||...|    |||.||| |.   |. .|||..    ||.. . . .|.| |.||.| .  .  |..     . |.|.||||| |||.|....
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvv.fgdn..irevvqlhytswpdmgvpkytipl

LQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNR
....|..|   . . |...|||||||||||||...|  |.||| |  ||.  .|...||.|.||||.|.|| |. ||.||.. ||.| .  .     .. 
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryds

MSKPDTKTGRTGFIDQF
.  |   || | . .||
llapspdtgstllqeqf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1051-1296 6.9e-80 262.9 In-house 3-245 (250) alignment 
Range on Protein: 1051-1296
Range on HMM: 3-245/250.0
IAVTPSNRPLNRFGNIVVYDDNRILLNQIPgnTDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIkCHQYWPE
.|  |.|.  ||. .|. .|  |..|..    .| . ||||| ...||..   .||||||...|..||||....|   .|||.|||||     .||||| 
vakkpqnkeknryadiialdssrvvLekek..gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

HGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMG
 ... ||  ...| .... .|||.||..|.   . .   .. |.||..||| ||||.||..|.. .... . .   ..|..|.|||||||.|.|.|||  
ekaekyGdvtvsllskeefadytkrklklska.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

LQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCG
|....||  .|.  .|...|..|...|.. .||.||  ..|. ... 
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
0045098 (Phosphotyrosine protein) phosphatases II 1045-1295 9.5e-80 263.2 In-house 21-274 (278) alignment 
Range on Protein: 1045-1295
Range on HMM: 21-274/278.0
NEHSVTIAVTPSNRPLNRFGNIVVYDDNRILlnqipgntdcqnDYINACYIDGYsqDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKC
.  ..| |. ..|...||. .|. || .|.             ||||| |||||  . |.||||||  .|. ||||..|... .||||.|.|.|.. .||
ipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

HQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLL---GSDQPPLMITQYHFTSWPDHGVPEYA--TSILQFHRRIKNEYK-------------PTK
.|||||.||  ||.|...|..|.|| |||.|.. .| |    .| ... .|..|...|||||||..   .|.|.. ..|.. .|             . .
aqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

GPMLVHCSAGVGRTGTFMAIDMGLQQAekEGGIDIISIINKMRQQRMK-MVQTADQYIFVNDAVLESVTC
||.|||||||||||||. |... |..   |||.|. ......|.||.  .||. .||.|. ...|| . .
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0040439 (Phosphotyrosine protein) phosphatases II 1049-1291 2e-79 262.0 In-house 3-244 (249) alignment 
Range on Protein: 1049-1291
Range on HMM: 3-244/249.0
VTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGntDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYW
...|  | |...||. .|. || .|. |. .||     .||||| ||||| .  ..|||||| ..|. ||||..|...  ||||.|.|.|   .||.|||
ysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAI
|. ||. || |...|....|. |||.|...|| |  |...........|.|||||||..  ..|.| ..... ..  |..||.|||||||||||||| |.
plggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
.. |.| |||.|.|. ......|.||...||. .||.|. .|.||
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 1050-1291 5.5e-79 260.3 In-house 2-241 (245) alignment 
Range on Protein: 1050-1291
Range on HMM: 2-241/245.0
TIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGntDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWP
..|  | |...||. .|. ||..|. |. ..|  |  .|||||.|.||| .  |.|||||| ..|. ||||..|...  .|||.|.. |.  .||.||||
svallpenkdknrysdilpydhtrvklspdgg..dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

EHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDM
...|. || |...|..|..| |||.|....| |  | .......||...|||||||..  ..|.|...... .. . .||.||||||||||||||.|...
lgesltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

GLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
 |.|.|||.|... ... ..|.||...||| .||.|. .|.||
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 1018-1309 2.1e-77 255.3 In-house 9-302 (307) alignment 
Range on Protein: 1018-1309
Range on HMM: 9-302/307.0
FGEFVANGHAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTDcqNDYINACYIDGYSQDYKYIATQGPVTKTLVD
  | . . . . ..|... | .|..   ..| ...    |   ||. .|. .|..|. |..|.|. |   ||||| .| || .  |.|| |.||  |. |
leealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingked..sdYinasfikgykekkkfiaaqdPveatigD

FWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQ----PPLMITQYHFTSWPDHGVPEYATSILQ
|||.|..    .|||..||.| .  ||..|||.   . ||   ..| .|.  .||.||.....  . .         ..|||.|.|.|  ||| |...|.
fWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllk

FHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVF
. ..... ||  ..|..|||||||||.|.|.|.|. ||| ..|  .||. .. ..|.||  .||  .||.|.  |.|.  . |.|..| ..    .
lieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledai
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1013-1300 1.7e-76 252.1 In-house 3-284 (315) alignment 
Range on Protein: 1013-1300
Range on HMM: 3-284/315.0
IPVGQFGEFVANGhaKGNEGFKNQYCTLNSGDNeHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIpgNTDCQNDYINACYIDGYSQDYKYIATQGPVT
||| ||  || .   .    | ...  |   |  .  ..| .. | . ||..||. .| .|. |. |  . . ..||||| || .. .|  |||.|||  
ipvaqfpafvnkn..rhtalfseefhdlpdPdi.yrqrvaretinfkknryknilPldsarvklevi..ddsPdsdyinasyiksvdddkayiasqgPlk

KTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPE--HGSTSYGPFRIELTKEQVLTDYTIRKMqLTLLGSDQppLMITQYHFTSWPDHGVPEYATS
 .. ||||...||..  |||||...|.  ||| ||||.    |. .| ...|| . .  || ..||.  |  . ..    .||..|| |||.||.. ..|
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrksees..rtvtqfqftewPdkGvdkqtss

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQV
.|.. . .| . .. . ..|||||||||||| ...||  ..|....  .|.  .....|..|...||| ..| |. ||||| .   || .
llklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntli
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1013-1303 4.5e-75 247.7 In-house 2-286 (515) alignment 
Range on Protein: 1013-1303
Range on HMM: 2-286/515.0
IPVGQFGEFVANGHAkgNEGFKNQYCTLnSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNtdCQNDYINACYIDGYSQDYKYIATQGPVT
.|. ||  ||.         | ...  |  | | .  |.|    | . ||..||. || .|. |. |  |   ..||.|| || ..  |  |||.|||  
lplaqfPafvnknrh..ttlfseefhdl.pgpniypqtvaqeeinfkknryknilPydsvrvklevindn..PhsdyfnasyipsfdndkayiasqgPnk

KTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPE--HGSTSYGPFRIELTKEQVLTDYTIRKMQLTlLGSDqpPLMITQYHFTSWPDHGVPEYATS
 .. |||||..||..  |.|||.|||.  ||| .|||.    |  .| ...||   .  |. ..||....  |.|     .||.||| |||.|||. ..|
asvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvl.kgdd..srtvtqfhfteWPdkGvpkhtss

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSR
.|.. . .| .    . |...|||||||||| ...||  . .|..   .|.  .....||.|...||| .|| |. .|||| .   || .   
llklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvi
subfamily_PTPN6_pd Subfamily PTPN6 1024-1294 1.1e-74 246.2 In-house 19-298 (306) alignment 
Range on Protein: 1024-1294
Range on HMM: 19-298/306.0
NGHAKGNEGFKNQYCTLNSGDNEH--SVTIAVTPSNRPLNRFGNIVVYDDNRILLNqipGNTDCQNDYINACYIDGYS--QDYKYIATQGPVTKTLVDFW
... ....||.... .|.  ....  | . .  |.|.  ||. ||. .|..|. |.    .   ..||||| ||.. .  .| .|||||| ...|. |||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

RLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGS-TSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRI
|..|||   ||||.|.  | .  || .|||.. . ..||  ... ..|. |.||..|.....   ...    . ||||.||||||||.    .|.| . .
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledv

KNEYKPTK----GPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---GIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVT
..... ..    ||..||||||.||||||. ||. |.. ||.|    ||| ......|.||  .|||..|| ||  |. . . 
nrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1026-1301 1.8e-74 245.1 In-house 4-274 (283) alignment 
Range on Protein: 1026-1301
Range on HMM: 4-274/283.0
HAKGNEGFKNQYCTLNSGDNEhsVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGntdcqnDYINACYID---GYSQDYKYIATQGPVTKTLVDFWRLI
....|. |....  |.  | .  ..||..  |.. ||. .||..| .|. |.  .       |||||..|     | || |||..|.|. .| ||||...
rvnnnklfrevlkrlsvpdld..adiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmv

WQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
..|.   |||.|.|.||  ||| ||||..||  ||.| . | ||     ..|... |   .| .  |... | .  | . |      |...| . | .  
fdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqt

KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVD
.  |||..||||.|.|||..|.|.   ...|  |  .|. .... ||.||| .||| ||| .| ..|||   ||.||. 
eskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_PTPN12_pd Subfamily PTPN12 1044-1294 8.5e-73 239.7 In-house 27-278 (290) alignment 
Range on Protein: 1044-1294
Range on HMM: 27-278/290.0
DNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTdcQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIK
....| . . ...|.  ||. .|. || .|. |..| ..   ..||||| .| | ... .|||.|||..||| ||||.||. .  ..||. .. |   .|
ekvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkk

CHQYWPEHGSTS--YGPFRIELTKEQVLT-DYTIRKMQLTLLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRT
|..||||.| ..  .|.|...|..|. .. |..|| ....  .  .   ...|.|.|.|||||||. |.|.|.. . ...  .  . |..||||||||||
CerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesr...kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrt

GTFMAIDMGL---QQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVT
|| .|||.     ..   .  .|. ... ..|.||  .||| .|| .|  ||.| |.
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
0037934 (Phosphotyrosine protein) phosphatases II 1050-1291 1.3e-72 239.6 In-house 3-240 (243) alignment 
Range on Protein: 1050-1291
Range on HMM: 3-240/243.0
TIAVTPSNRPLNRFGNIVVYDDNRILLnqipgnTDcqNDYINACYIDGYSqdyKYIATQGPVTKTLVD----FWRLIWQERPPVIVMVTNLKEDTTIKCH
.||  | |.. ||. .|. ||..|. |       .  .||||| .|...    ..|||||| ..|. |    |||..|...  ||||.|.|.| . .||.
siallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPehGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--------YKPTKGPMLVHCSAGV
||||  |.. ||.|...|..|..| |||.|...|. |. |........||...|||||||.  ...|.|.. ...         . ...||.||||||||
qywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTFMAIDMGLQQAekegGIDIISIINKMRQQRMK-MVQTADQYIFVNDAVLE
|||||. |... |..     |.|. ......|.||.  .||| .||.|. .|.||
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
0050432 (Phosphotyrosine protein) phosphatases II 1311-1587 5e-72 238.2 In-house 31-306 (308) alignment 
Range on Protein: 1311-1587
Range on HMM: 31-306/308.0
RMSKPDTKTGRTGFIDQFTVLEQVTQrPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLkGEHPDYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMI
 . . . .......  .|  | .|.  . | ..    .| ||||.. .|| |. || | .|. ||||| ...||  | ...||.. .|. ||  .||.|.
llkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmv

DDRNVTAIVMLCHEKEIDQEVCYQYWPST--PSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYK
 . ||. ||||. . | ..| |.||||..   . |..| . . | |||....|. |.||..|...| .  |.... |||       .|. .|. .|.. |
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrk

TQrrrGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYS
..   ..  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||..||. .....| || ...|. 
sl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1319-1585 1.6e-71 236.0 In-house 19-288 (305) alignment 
Range on Protein: 1319-1585
Range on HMM: 19-288/305.0
TGRTGFIDQFTVLEQVtQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEHP--DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
.  .|.  |.  | .  . . .|... |........... |. | ...  | ...  ||||| ...|||.||..|.| .|. || ..||..| .  |. |
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLCHEKEIDQEVCYQYWPSTPSG-LVIGEYAIMLSSEEIYNGYIERKLEVKN-TNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGNT
|||.. .| ... |.|||| . .    .||. ..|.||. ...||||||.. .  .   ...|.|||.|.|       .. ..||.|... |.|..  ..
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
...||||..|||. .|.|    ....|.|.|.|||.|||  | .... ||| .||. .....  .. ...|
pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
subfamily_PTPN9_pd Subfamily PTPN9 1020-1291 4.2e-71 234.4 In-house 5-288 (297) alignment 
Range on Protein: 1020-1291
Range on HMM: 5-288/297.0
EFVANGHAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTdcQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFW
|.||  ..||..| ...|  . .   |  .. . ...|   ||. ... ||. |. |.......  . ||||| ..||| |   .||||||. ||  |||
elvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfW

RLIWQERPPVIVMVTNLKEDTTIKCHQYWP--EHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRR
|..|...  ||||.| . |   .|| ||||  |. |...| ....  . ..  ||..|.....    ..    .| . |.||||.|||. |.|.|.. . 
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktees.rkvthfqflsWPdyGvPssaaslldvlek

IKN-------------EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
...             ...|.. |..||||||.||||||...|. |.. |..| .|..  ....|.||  ..|| .|| |   ||||
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1296-1586 2e-70 232.4 In-house 1-296 (298) alignment 
Range on Protein: 1296-1586
Range on HMM: 1-296/298.0
GNTQVDSRNARIVFNRMSKPDTKTGRTGFIDQFTVLEQVTQRPDEVTHNIA--SQNNDKNRSTQFLPRDNYRVPLKG----EHPDYINAVFINGYKEKKA
|||...... .. ...... . |.. ||. ..|  |..|... .| ....|  ..|..||| .. .. |  || |.     |. |||||.|...||...|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGlVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTR
||... |. .|  .||.|. ......||||   .| |.  . .|||.. .    ||  . | |.| .  .| |||.|..... ....| | . |.| .  
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

KMAKPQTILSVIEEMYKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
  .. ...| ..... ..|.. ||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| .||  |...|| .||||...
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1041-1312 2.4e-70 232.4 In-house 45-310 (319) alignment 
Range on Protein: 1041-1312
Range on HMM: 45-310/319.0
NSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTdcQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTnlkedt
. | |    | |  . |.  ||..||. .| |.. |... |      ||||| ...|| .  ||||.|||   || ||||.||. .   ||..|      
klgvnladqtfanldqnkdknriinilafdknvvklerliGee..fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......

TIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVG
  || |||| ..   .. | ....  .   .|..|...|.  |  .    |||.||  |||.|||.|.. .... ....     .  . ...||||||||
kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvG

RTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRM
|||.....|. |.. ..|  .|.  ... .|||| ..||   || |.  |.||    |...|   .    ....
rtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1057-1291 6.5e-70 230.0 In-house 7-238 (239) alignment 
Range on Protein: 1057-1291
Range on HMM: 7-238/239.0
NRPLNRFGNIVVYDDNRILLNQIpgNTDCQNDYINACYIDGYSQDYK-YIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGStS
|.  ||. ||| || .|..|...  . | ..||||| |.  |    | |||||| |. .  ||||..||||  ||||.| | |    |||||||.  |  
nkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.k

YGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEK
|  .|. | | .|..|| || . .. .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.|
ycnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
.  .||.  .. .|..| .||||..||.|.  ||||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1041-1312 1.2e-69 229.9 In-house 9-274 (284) alignment 
Range on Protein: 1041-1312
Range on HMM: 9-274/284.0
NSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTdcQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTnlkedt
. | |    | |  . |.  ||.|.|. .| |.. |... |.     ||||| .| || .  ||||||||   || ||||.||. .   ||..|      
klgvngtdqtfanldqnkdknrighilafdknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......

TIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVG
  || |||| ..   .. |.....  .   .|..|...|.  |  .    |.|.||  |||.|||.|.. .... ....     .  . ...||||||||
kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvg

RTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVFNRM
|||.....|. |.. ..|  .|.  .....|||| ..||   || |.  |.||    |...|   .    ....
rtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1057-1291 1.2e-69 229.2 In-house 8-239 (239) alignment 
Range on Protein: 1057-1291
Range on HMM: 8-239/239.0
NRPLNRFGNIVVYDDNRILLNQIpgNTDCQNDYINACYIDGYSQDYK-YIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGStS
|.  ||. ||| || .|..|...  . | ..||||| |.  |    | |||||| |. .  ||||..||||  ||||.| | |    |||||||.  |  
nkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.k

YGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEK
|  .|. | | .|..|| || . .. .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.|
ycnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
.  .||.  .. .|..| .||||..||.|.  ||||
qktvdifnyvkairedrphmvqtseqyvfihlavle
0047943 (Phosphotyrosine protein) phosphatases II 1316-1580 4.1e-69 228.4 In-house 6-272 (273) alignment 
Range on Protein: 1316-1580
Range on HMM: 6-272/273.0
DTKTGRTGFIDQFTVLEQVTQrPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
....|.|... .|  | ...  . . .. .  .| ||||.. .|| |. || |.... ||||| ...||. |..||... |. ||  .||.|. . ||. 
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLCHEKEIDQEVCYQYWPSTPS--GLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRR-G
||||. . | ..| |.||||..     |. |.. . | |||....|. |.||..|..|| .  |.... |.|      . .. .|. ||.. |...   .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||..||. . ...| ||
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 1313-1580 4.2e-69 228.5 In-house 18-286 (288) alignment 
Range on Protein: 1313-1580
Range on HMM: 18-286/288.0
SkpdtKTGRTGFIDQFTVLEQVTQRpDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
     ..| ||....|  | ...    .... .  .| .|||.. .|| |. || |.     |. ||||| .|.||. |..||... |. ||  .||.|.
l....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmv

DDRNVTAIVMLCHEKEIDQEVCYQYWPStPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNT----NTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEM
 . ||. ||||. . | ..| |.||||.  . |..|.. . | |||....|. |.|||.|.     .| .. |.... |||        |. .|. ....
weqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlv

YKTQRrRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.| ..  |.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||..||. .....| ||
rkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 1318-1586 1.9e-68 226.3 In-house 9-283 (297) alignment 
Range on Protein: 1318-1586
Range on HMM: 9-283/297.0
KTGRTGFIDQFTVLEQVTQrPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIV
.......  .|  | ..   . . .. .  .| .|||.. .|| |. || |..|. ||||| ...||. |..||... |. ||  .||.|. . ||| ||
llflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLCHEKEIDQEVCYQYWPST-PSGLVIGEYAIMLSSEEI--YNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRR-GN
||. . | . | |.||||.. .. |. |.. . | |.|.  ...|. |.|||..|..| .  |.....|.|        |...|. ||.. | ..   ..
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

TSIVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
. ..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||..||. . ...| .| ...|.
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0046845 (Phosphotyrosine protein) phosphatases II 1324-1588 2.4e-68 225.9 In-house 2-282 (284) alignment 
Range on Protein: 1324-1588
Range on HMM: 2-282/284.0
FIDQFTVLEQVTQRPD-EVTHNIASQNNDKNRSTQFLPRDNYRVPLKG-----EHPDYINAVFINGY-----KEKKAFIIAESPMFNTARNFWKMIDDRN
....|  | ..|  .  .... .. .| .|||....|| |. || ||      |. ||||| ...||     . ||.||..  |. ||  .||.|. . |
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VTAIVMLCHEKEIDQEVCYQYWPSTPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTN-TGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRR-
|. ||||. . | ..| |.||||.. . |..|.. . | |||....|. |.||..|.. || .  |.....|.|      . |. .|. .... . ... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
 |.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||..||. .....| || .. |. .
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1056-1291 2.7e-68 224.7 In-house 2-237 (237) alignment 
Range on Protein: 1056-1291
Range on HMM: 2-237/237.0
SNRPLNRFGNIVVYDDNRILLNQIPGNtdcqNDYINACYIDGYSQ-DYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHG-S
 |.  ||.||||.|| .|..|.   ..     |||||.|..|.     ||||.|||.  .  |||...|||.  ||||.| | |   .|||.|||.    
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

TSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQ
..|| . . |.|.. ..|||.| . |.  .. .   .| ||.||||||.|||......|.| ..| |. .  .  || ..|||||||||| |. ||  |.
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
||...  .||   .  . ..|  ..|| |||.|.....||
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN3_pd Subfamily PTPN3 1036-1291 5.4e-68 223.9 In-house 20-273 (280) alignment 
Range on Protein: 1036-1291
Range on HMM: 20-273/280.0
QYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQipgntdCQNDYINACYID----GYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIV
|. .|   ... ....|  | | . ||. .|. ||. |. |..       ..||||| |..    . ..  .|||||||..||  |||...|...  .||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklke......setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MVTNLKEDTTIKCHQYWPEHG-STSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPML
|.|.| |.  .||||||||.. ...|| |.....||.  . | .|.. |.   ...   .|.|  ...|||||||. ....|.| .|...  . .. |..
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketke.erkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvv

VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
||||||.|||| ...... |.  |..  . .. |. .||.||. .||||.|| || .|.|.
vhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1056-1290 3.6e-67 221.4 In-house 27-265 (274) alignment 
Range on Protein: 1056-1290
Range on HMM: 27-265/274.0
SNRPLNRFGNIVVYDDNRILLNQIPGNtDCQNDYINACYIDGYSQDYK-YIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGST
 .   ||. .|.  .  |.||..  .. | . .|||| || ||... | |.|||||...|. ||||.|.||. .||||.|.|||    ||..|.|.. ..
gsqtknryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----SYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPplmITQYHFTSWPDHGVPEYATSILQFHRRIKNE---YKPTKGPMLVHCSAGVGRTGTFMAID
     || . |. .|     ||..||. |  | . .    .. | .|.|||| .|. |...|.. . ....    .   .|..||||||.|||| |.||.
eiserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

MGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVL
....| ..|. .|...|. ..|..|  ||||..|| ..  |. 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1011-1301 6.8e-67 220.7 In-house 8-292 (297) alignment 
Range on Protein: 1011-1301
Range on HMM: 8-292/297.0
NLIPVGQFGEFVANGHAKGNEgFKNQYCTLNSgdNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIpgNTDCQNDYINACYIDGYSQdyKYIATQGP
. ||. .|  .| ...    .  ..  |....  | .. | |    | . .|. ||. || .|. |. .  |.| . ||.|| .. |. .  ..|.|| |
rpiplsdfatlvqknrhtdvf.seeflclpea..niqpqtvaekkvnfeksRYkniLPydssRvkLaiv..nddpdsDyvnasfvkgnkh..rlittqmP

VTKTLVDFWRLIWQERPPVIVMVTNLKEDTTiKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLlGSDQPPLMITQYHFTSWPDHGVPE--YA
   |. |||.....|.. .|||.....| .  || .||...|.|..|   ..|.  .  . .  |....|  |. .   .. ||.|..|||. |..   |
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsa

TSILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVD
.|.|..   ...... ..  |.||||.||||||| ...||  . .|..|  .||  ...|.||.|...||| .|| ||  |||| . . .|...
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1015-1302 3.2e-66 218.7 In-house 7-297 (325) alignment 
Range on Protein: 1015-1302
Range on HMM: 7-297/325.0
VGQFGEFVANGHAKGNEGFKNQYCTLNSgDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIpgNTDCQNDYINACYIDGYSQDYKYIATQGPVTKT
| .. |.| . .|. ..|| ...  | | |.  . ..|. | |.  ||| |.| .| .|. |.    . | . ||||| |.  . .   ..|.| | |.|
vvnlvehvekkkaqdqdgfahefgllps.ddgiakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltat

LVDFWRLI--WQerPPVIVMvTNLKEDTTIKCHQYWPEH--GSTSYGPFRIELTKEQVLTDYTIRKMQLTLLgSDQPPLMITQYHFTSWPDHGVPEYATS
. |.|||.  |.   .|.|. .|  .    .| .|||..   |  .|.....|   . ..||  |....    ..   . . |... ||.| ||... ..
indlWrlvldWr..csvvvv.lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqv.kkGetrsvkqfqlqswddmGvqkrpat

ILQFHRRIKNEY---KP---TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDS
.. . . .|.     .    . .|.||||||||||||.|...   |..  .|  .||   ..|.|..| .||.|.||||.. .|. | . .|||.|  
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpv
0040438 (Phosphotyrosine protein) phosphatases II 1322-1586 5.7e-66 218.3 In-house 18-282 (317) alignment 
Range on Protein: 1322-1586
Range on HMM: 18-282/317.0
TGFIDQFTVLEQVtqRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIV
|.. ..|  | ..   .|. .. .  .| ||||.. .|| |. || |. .      ||||| ...|...|..||.. .|. ||  .||.|. . .|| ||
talleefedllsl..kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLCHEKEIDQEVCYQYWPStPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRrRGNTSIV
||....| ..| |.||||.  . |..|.. . | ||| ..|.. |.|||...... .  |.... |.|        |...|. .|.. . .. .... ..
mLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvl

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
||||. |||...|.|| . .. ...|| .||....|  | |.||.||| .||. . ...| ||  ..|.
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
subfamily_PTPRD_pd Subfamily PTPRD 1341-1586 2.3e-65 216.3 In-house 40-287 (564) alignment 
Range on Protein: 1341-1586
Range on HMM: 40-287/564.0
VTHNIASQNNDKNRSTQFLPRDNYRVPLK----GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPS
...  ...|  |||  . .. |. || |.     |  ||||| ||.||...||.| .  |. .| ..||.|. ..|.. |||| . .| ... | .|||.
weaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPe

TpSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQrRRGNTSIVVHCSDTVGRSAMFCAAATT
. .   .||. . |..|| .. |. |....|.... ... | |.. |.| ..  . .....|..|... ... ....  ||||||  |||. .|..    
k.gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividam

INKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETY
... |.|...|..|..|  | |..  ||| .||. |....| .|....| 
lerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
0045450 (Phosphotyrosine protein) phosphatases II 1314-1580 4.4e-65 215.7 In-house 19-304 (307) alignment 
Range on Protein: 1314-1580
Range on HMM: 19-304/307.0
KPDTKTGRTGFIDQFTVLEQVTQR-PDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKG-----EHPDYINAVFI--------NGYKEKKAFIIAESPMFN
. ......||.  .|  | .|| . ..| ..    .| ||||.. .|| |. || |.      |. ||||| ..        .||. |..||.. .|. .
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNT-NTGSTQSVMQYQITNWVSTRKMAKPQTIL
|  .||.|. . .||.||||....| ..| |.||||.. . |..|.. . | |||...||. |.|||...  || .  |.... |.|  .     ....|
tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeell

SVIEEMYKTQRRR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
. |||. | ...  ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||. .||. . ...| .|
dfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPN13_pd Subfamily PTPN13 1037-1293 1.7e-64 212.8 In-house 17-269 (273) alignment 
Range on Protein: 1037-1293
Range on HMM: 17-269/273.0
YCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGntdcqndYINACYIDGY--SQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVT
. .|.      ..... . .|.  ||. |.. ||. |. |..  |       |||| .|      . |.|||.|||. .|  |||...|. .  ||.|||
fkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

NLKEDTTIKCHQYWPEHGS---TSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLV
. ||.  .|||.||||. .   . .. ...|| | | | ....|..... . | .    ... .|..|||||||  |...||| .....  .  .||..|
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivv

HCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESV
|||||.||.||...||. |.  |..  .|.  |..|.|.||  .||| ||||||  |.|| .
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1320-1588 2.5e-63 208.6 In-house 13-301 (301) alignment 
Range on Protein: 1320-1588
Range on HMM: 13-301/301.0
GRTGFIDQFTVLEQVTQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLK----GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
  ..| .|.. |....... .|... . .. ....... .. ..  .  |      . .|||| .|.||.|||.||.|..|| .| ..||..| .  ...
hsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

IVMLCHEKEIDQEVCYQYWPST-PSGLVIGEYAIMLSSEEIY-----------------NGYIERKLEVKNTNtgSTQSVMQYQITNWVSTRKMAKPQTI
|||.. .||  .. |.||||..  .    |.  ..|..| .|                 |||||||..||...  |...|.|.|.|.|     .  |.|.
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtv

LSVIEEMYKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
| ||... ..|.. |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.| .||  |.... .||   .||.|
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
DSPc_SM00195 1326-1580 4.7e-63 208.3 In-house 4-262 (263) alignment 
Range on Protein: 1326-1580
Range on HMM: 4-262/263.0
DQFTVLEQVTQRPdEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
 .|. ||. |.   |.|... ..|..|||....|| |. || || |.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||. 
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

EKEIDQEVCYQYWPSTP-SGLVIGEYAIMLSSEEIYN-GYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRgNTSIVVH
|.| ..| |..|||..  .  ..|.. . | ..|...  .| |.||......  |..| |||..||       ... .|.......|....  .. ||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVh

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
||. |||...|... . ..|...|  .|.|...|. | |.||.||| .||. | ...| |.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1326-1580 4.7e-63 208.3 In-house 4-262 (263) alignment 
Range on Protein: 1326-1580
Range on HMM: 4-262/263.0
DQFTVLEQVTQRPdEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
 .|. ||. |.   |.|... ..|..|||....|| |. || || |.     ||||| .|.|...||..|..  |. .| . ||.|. ...|. ||||. 
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

EKEIDQEVCYQYWPSTP-SGLVIGEYAIMLSSEEIYN-GYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRgNTSIVVH
|.| ..| |..|||..  .  ..|.. . | ..|...  .| |.||......  |..| |||..||       ... .|.......|....  .. ||||
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVh

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
||. |||...|... . ..|...|  .|.|...|. | |.||.||| .||. | ...| |.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0039614 (Phosphotyrosine protein) phosphatases II 1315-1584 8.1e-63 208.0 In-house 25-293 (297) alignment 
Range on Protein: 1315-1584
Range on HMM: 25-293/297.0
PDTKTGRTGFIDQFTVLEQVTQrpDeVTHNIASQNNDKNRSTQFLPRDNYRVPLKG-----EHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMI
 ......|... .|  | ...   |  ..    .| ||||.. .|| |. || ||.     .. ||||| ...||.  ...||..  |. .|  .||.|.
lekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

DDRNVTAIVMLCHEKEIDQeVCYQYWPSTPSglVIGEYAIMLSSEEIYNGYIERKLEVKNtnTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQ
 . .||.||||. ..| ..  |.||||.. .  . |.. . | ..| ..||. |.|||.|  .| .  |...| |.|        ....|...|.. . .
weqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

RRR-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFE
..  ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| .||. .....| .|  . 
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0043336 (Phosphotyrosine protein) phosphatases II 1318-1580 3.4e-62 205.7 In-house 16-277 (278) alignment 
Range on Protein: 1318-1580
Range on HMM: 16-277/278.0
KTGRTGFIDQFTVLEQVTQrpDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
....|... .|  | ...   |. .. .  .| ||||.. .|| |. || |. .      ||||| ...||. ...||..  |. .|  .||.|. . .|
lnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

TAIVMLCHEKEIDQEVCYQYWPstPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRrRGN
| ||||. ..| ... |.||||   . |..|.. . | .|| ...|. |.|||.|. .| .. |..|. ..|        ....|. .... . ..   |
ttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsn

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
. ..||||. |||...|.|. . ..  ..|| .|.....|  | |.||.||| .||. .....| ||
gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1322-1578 3.6e-62 204.8 In-house 6-264 (283) alignment 
Range on Protein: 1322-1578
Range on HMM: 6-264/283.0
TGFIDQFTVLEQVTQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEHPDYINAVFIN---GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVM
...  .. ||....  . ... . |..|. |||  . .| |..|| || | .||||||||     ||..| .||| ||. .| ..||||. |...|||||
nnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm

LCHEKEIDQEVCYQYWPSTPSgLVIGEYAIMLSSEEIYNGYIERKLEVKNT-NTGSTQSVMQYQITNWVSTRKMAKPQTILsVIEEMYKTQRRRGNTSIV
| . .|  .. | ||||.  |    ||... |  |   | .| ..| ...   . ||  .  ||. .|..  . |   ...  .. .   |..  .. ||
ltklqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslv.kfnkvislqteskkgPiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
|||| ..||.|.|.||...... .|| |.|||.|.|  | |... ||| .||. . ..|| 
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
Y_phosphatase Protein-tyrosine phosphatase 1349-1577 4e-62 205.1 Pfam-A 1-234 (235) alignment 
Range on Protein: 1349-1577
Range on HMM: 1-234/235.0
NNDKNRSTQFLPRDNYRVPL--KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWP-STPSGLVIGE
| .|||....|| |. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....| ..| | |||| ..   |  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YAIMLS-SEE-IYNGYIERKLEVKNTNTGS-TQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQrRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
. . |  .|. . ..|. ||||.|.... | ...|.|...|||      ..|. .|..|... |.. .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
|. .||.|..|. | |.||.||...||. . ...|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1349-1577 4e-62 205.1 In-house 1-234 (235) alignment 
Range on Protein: 1349-1577
Range on HMM: 1-234/235.0
NNDKNRSTQFLPRDNYRVPL--KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWP-STPSGLVIGE
| .|||....|| |. || |  .... ||||| ...||||||.||... |. .|   ||.|. ...|..||||....| ..| | |||| ..   |  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YAIMLS-SEE-IYNGYIERKLEVKNTNTGS-TQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQrRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
. . |  .|. . ..|. ||||.|.... | ...|.|...|||      ..|. .|..|... |.. .  ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
|. .||.|..|. | |.||.||...||. . ...|
eeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPRN_pd Subfamily PTPRN 1028-1293 8.8e-62 203.5 In-house 26-292 (297) alignment 
Range on Protein: 1028-1293
Range on HMM: 26-292/297.0
KGNEGFKNQYCTLNSGDNEHSVT-IAVTPSNRPLNRFGNIVVYDDNRILLNQIpgNTDCQNDYINACYI-DGYSQDYKYIATQGPVTKTLVDFWRLIWQE
| .. ..... .| . ..| |.. .| .. |   ||  ... ||..|. |..   ... ..|||||  | |   .   |||||||...|. |||...|..
knkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkee..asaeksdyinasaildhdprapayiatqgplastvadfwqmvweq

RPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLT-DYTIRKMQLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP
   |||..|.|.|. . .|..|||..||  |. . ..|  | . . || .| . |  | ...    .||.|| |||..|||  | |.|.| |..   |. 
GvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPasaksllefrrkvnksyrG

TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESV
   |..||||.|.||||....||. |..  |    |||.. ....|.|| ..|.| ||. |.  || | |
rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1320-1588 3.5e-61 202.0 In-house 18-288 (318) alignment 
Range on Protein: 1320-1588
Range on HMM: 18-288/318.0
GRTGFIDQFTVLEQVTQRPDEvTHNIASQNNDKNRSTQFLPRDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
|.. .  ..  |..... . . .. . . |. ||| .  |. |. || |.     |  ||||| .|.||..|||.| | .|. .| ..||.|. ..| . 
Gelllseeyerlsrseetvts.lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMLCHEKEIDQEVCYQYWPSTPSgLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGNTS
|||| .|.|  .. . .||||  |   .|.  . |..|  .. |. |...|..|.. ... | ||..|.|  .   ... ..|... .  |.|.. |.. 
ivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
||||||  |||  .|.|  . ... | |...||||. |  | |..  ||| .||. |....| .| |..|. .
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1018-1309 4.5e-61 201.6 In-house 7-295 (439) alignment 
Range on Protein: 1018-1309
Range on HMM: 7-295/439.0
FGEFVANGHAKGNEGFKNQYCTLNSGDNE--HSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTdcQNDYINACYIDGYSQDYKYIATQGPVTKTL
| | | . . . .| ||. . ..|| . .     ..|    ... ||. ... .|  |. |..|||    .  |||| ||.|| .|  |||||||  .| 
fqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvp..hshyinanyikGyyddklyiatqgpkkett

VDFWRLIWQERPPVIVMVTNLKEDTTikchqYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTL-LGSDQPPLMITQYHFTSWPDHGVPEYATSILQF
 |||||.....   |||.||| |        |||  . . ||   .   ..  | .|.|| ...     . .    . |.|...|||. ||  |. .|.|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

HRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQVDSRNARIVF
 | |.  . |   ||..|||||||||||| .|.|. |.|   |  .||  |.. .|.|| .|||.  ||.|. .|||| .  |.. |   . .  |
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkef
subfamily_PTPN1_pd Subfamily PTPN1 1033-1302 4.9e-61 201.0 In-house 8-282 (290) alignment 
Range on Protein: 1033-1302
Range on HMM: 8-282/290.0
FKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQipgntdCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVM
.|. | ...   ...... | .|.||.|||. ..  ||  || |..       .||||||  ..    . .|| ||||...|   ||...|...   .||
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikler......adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

VTNLKEDTTIKCHQYWPEHGS---TSYG--PFRIELTKEQVLTDYTIRKMQLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPT
. .. |  .|||.||||.. .     .    ....| .|..   ||.|...|. | ...    |...|.|.||| ||||  .. |.|  ....    .. 
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqet.reilhfhyttwpdfgvpespaaflkflfkvresGslssd

KGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVT--CGNTQVDS
.|| ..|||||.||.|||. .|  | . ||..    .||   . ..|..|. ..|||||  |   |.|| .    |.. |..
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1048-1292 3.4e-60 198.3 In-house 11-263 (270) alignment 
Range on Protein: 1048-1292
Range on HMM: 11-263/270.0
SVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIpgNTDCQNDYINACYIDGYS-QDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQ
. ..  .  .. |||. .|.     |. |...  ..| .  |||| |. |.. .. ||||..||.  || .|||.||.|. . |||.|.|.|. . || .
esdlpeaargkklnRyadiLPsPatRvrleel..eedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCer

YWPEHGST----SYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQpPLMitQYHFTSWPDHGVPEYAT------SILQFHRRIKNEYKPT-KG-PMLVHCS
|||..  .    ..|  ..  ..|.  . | .....|.  |. .  |.   .....|||||||. .       ..|.  | ...  | . |. |.|||||
YWpaepkekvkledgkikvlalseekeegyiltrlrleekgeer.rlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

AGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLES
||||||||..|.|....  |... .|...||...|..||..||. .|| |.  ||.| 
aGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_PTPN23_pd Subfamily PTPN23 1029-1294 5e-60 197.7 In-house 13-281 (288) alignment 
Range on Protein: 1029-1294
Range on HMM: 13-281/288.0
GNEGFKNQYCTLNSGD----NEHSVTIAVTPSNRplNRFGNIVVYDDNRILLNqipgntDCQNDYINACYIDGYSQ-DYKYIATQGPVTKTLVDFWRLIW
|. ......  |.. .    ...|..|| . |..  ||. .|. || ||. |.      . ..|||||... . |    ..||||.|  .|| |||....
gktaldkkfkeleqkqdkearkrsiaiaklysek..nrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvy

QERPPVIVMVTNLKEDTTIKCHQYWPEH--GSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
... .||||... .|    |...||||.   ....|.... | ... .  .  |...|. |..|.   ...  ..||||..|||.   ..|||   ... 
eqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadav.ksvshlqltsWpelGvPasPetllqfldevesa

----YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINKMRQQRMKMVQTADQYIFVNDAVLESVT
     ...| |..|||||||||||.|  .   ... ||. |. ||| .....|.||  |||. .|. |. .|||| . 
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
0045098 (Phosphotyrosine protein) phosphatases II 1334-1581 9.5e-60 197.7 In-house 18-273 (278) alignment 
Range on Protein: 1334-1581
Range on HMM: 18-273/278.0
VTQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPlkgehpDYINAVFINGYkeKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQY
..  |.|.|...   | |||| ...|| |. ||       ||||| .|.||  .|.||..  |. .|. .||.|. . ..|.||||....| ..| |.||
llgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPStPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNT----NTGSTQSVMQYQITNWVSTRKMAKP--QTILSVIEEMYKTQR------------RRGNTS
||.  . |..|.. . | |||... |. |.|.| |.    ... .  | ......|        |  . .|...|.. . ..              ... 
wpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

IVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVQQYQGIFQIVLTYLD
..||||  |||.....|| . .  .  ||..|.....|  | |.|| .||. .||. ... .| .| 
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1347-1588 1e-59 196.8 In-house 7-250 (250) alignment 
Range on Protein: 1347-1588
Range on HMM: 7-250/250.0
SQNNDKNRSTQFLPRDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEvCYQYWPSTPSgLV
 ||..||| ..... |. || |. |.     |||||.|..||.|.||||.. .|. .|  .||.|. ......||||   || ... . ||||   .   
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka.ek

IGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 |.  . | |.|..  |. ||| . ...  . . | |.. ..|      .. ...| ..... ..|.. ||. ..|.||  ||||  |.|  . ... |.
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFETYSN
| |.|||.|.|  |...|..|.. .||  ...|.| .|||.| |..
ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_CG7180_pd Subfamily CG7180 1052-1298 7.3e-59 193.8 In-house 37-295 (296) alignment 
Range on Protein: 1052-1298
Range on HMM: 37-295/296.0
AVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTDcqNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTiKCHQYWPEH
..   ||  ||  ..| || ||..|... |. .  .||||| |.|.. .. .|| |..|...|. .||||...|    .|..|.  . .  ....|||..
glrkenreknrdvkvvPyDynRvvLekldGeek..sdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

GSTSYGPFRIELTKEQVLTDYTIRKMQLTLL---------GSDQPPLMITQYHFTSWPD-HGVPEYATSILQFHRRIKN-----EYKPTKGPMLVHCSAG
. . ||.. .|...|. ... .||...||           . . .  .......| |.  . ||  ....... ||..      . .|..||..|..| |
skeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

VGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNT
..|.| ..|||. |...|||. .|.   . ..|..| ..|.. ..| .. | .|| | |. .
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
0040439 (Phosphotyrosine protein) phosphatases II 1341-1580 3.7e-58 192.4 In-house 3-246 (249) alignment 
Range on Protein: 1341-1580
Range on HMM: 3-246/249.0
VTHNIASQNNDKNRSTQFLPRDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPS
... .   | ||||.. .|| |. || |.     .. ||||| .|.||. |..||..  |. .|  .||.|. . ..|.||||....| ..| |.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

tPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRR-GNTSIVVHCSDTVGRSAMFCAAAT
  . |..|.. . | |.|....|. |.||..|. .|..  |...|.|.|  .     ....|. ||.. | ...   .. ..||||. |||...|.|| .
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 ..  ..|. .|.....|  | |.||.||. .||. . ...| .|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 1346-1580 3.7e-58 192.2 In-house 6-243 (245) alignment 
Range on Protein: 1346-1580
Range on HMM: 6-243/245.0
ASQNNDKNRSTQFLPRDNYRVPLKGEH----PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPStPSGL
   | ||||....|| |. || |. .      ||||| ...||. .. ||..  |. .|  .||.|. . ..|.||||. | | ... |.||||.  . |
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

VIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCK
..|.. . | |||....|. |.|||.|. .. .. |..|. ..|        ....|...|.. | ... .|. ..||||. |||...|.|| . ..  .
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqle

TEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.|. .......|  | |.||.||| .||. . ...| .|
kelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1319-1585 2.5e-56 186.0 In-house 20-288 (319) alignment 
Range on Protein: 1319-1585
Range on HMM: 20-288/319.0
TGRTGFIDQFTVLEQVTQRpdEVTHNIASQNNDKNRSTQFLPRDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
|| |..  .|  |.. ..   ....    .|..||| .. |. |. || |.     |  ||||| ||.||.|...|| . .|. ||  .||.|. .... 
tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

AIVMLCHEKEIDQEVCYQYWPSTPSgLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGS-TQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGN
 .|||.. .|  .  . .|||..    . |.. . | .||  ..|| |||.... ..   | .|...| |.|       | ...| ..... |....  .
ivvmltklveklkvklkkywpeenf.eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqs

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||. .||. |....| ......|
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1012-1300 7.7e-56 184.2 In-house 3-243 (392) alignment 
Range on Protein: 1012-1300
Range on HMM: 3-243/392.0
LIPVGQFGEFVANGHAkgNEGFKNQYCTLNSGDNeHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNtdCQNDYINACYIDGYSQDYKYIATQGPV
 ||| ||  || . .   .  | ...  | . |  .  |.| .. | . ||..||. || .|. |. |      ..||.|| ||... ..  |||.||| 
pipvaqfpafveknrh..salffeefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddi..pdsdylnasyipsfdnekayiasqgpn

TKTLVDFWRLIWQERPPVIVMVTNLKEDTtikchqywpehgstsygpfrieltkeqvltdytirkmqltllgSDQPPLMITQYHFTSWPDHGVPEYATSI
. .| ||||...||..  |.|||.|||                                               .    ..|.||| |||..||....|.
aaslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssl

LQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQV
|.| . .| ..     |...||||||||||  ..||  . .|.|   .|.. .. ..|..|  |||| .|| |.  |||| .   || .
lkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntli
subfamily_PTPN14_pd Subfamily PTPN14 1046-1293 1.1e-55 183.7 In-house 38-296 (300) alignment 
Range on Protein: 1046-1293
Range on HMM: 38-296/300.0
EHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQipgNTDCQNDYINACYIDG--YSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIK
.  .. |  | | . ||| ... |.|||. |.    . . ...||||  |     .....||..|||. .|. |||...|..   .|||.|. .||   |
dallstaklpenaeknrfkdvlPyednrvelsp...tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

CHQYWPEH----GSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQP-PLMITQYhfTSWPDHGVPEYATSILQFHRRIK------NEY---KPTKGPM
...|.|..     .  .| |..     .  . .. ....|  | | .   ... ||  | ||||||||  .. |.. ....      |.    | .| |.
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPv

LVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESV
||||||||||||  .  |. ..  |..  ||| ......|.||| .|||  || || .......
lvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPRA_pd Subfamily PTPRA 1345-1579 1.3e-54 180.3 In-house 52-294 (330) alignment 
Range on Protein: 1345-1579
Range on HMM: 52-294/330.0
IA--SQNNDKNRSTQFLPRDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTP
.|   .|..|||  . || |  || |    | |. ||||| ||.|||||. || |  |  .|  .||.|| ... ..|||| . || ..| |.||||.  
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG

SgLVIGEYAIMLSSEEIYNGYIERKLEVK----NTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGNtSIVVHCSDTVGRSAMFCAAA
. .  |.  . .  |.. . |  ||. |.    .|.  ... | |.  | |      ..|. .|...... |.... .. .||||||  |||.  |..  
l.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivld

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
. ... |.|...|||...|. | |.|  ||| .||. |....| |
avlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
0051429 (Phosphotyrosine protein) phosphatases II 1087-1292 1.6e-53 177.4 In-house 4-224 (272) alignment 
Range on Protein: 1087-1292
Range on HMM: 4-224/272.0
NDYINACYIDGYSQ---DYKYIATQGPVTKTLVDFWRLiWQERPPVIVMVTNLKEDTTIKCHQYWP------------EHGSTSYGPFRIELTKEQVLTD
..|||| ...|| .   . ......|| . |  ||||| ....  .||..... |    ||..|||            .. . .|| .|. |..|..|.|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYAtsILQFHRRIKNeykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID--------IIS
|..|...|||| | . .......|.|.|||||||. |  .|.. . . .     .||.|||||||..||||. |... |.. ..|  .|        .  
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

IINKMRQQRMKMVQTADQYIFVNDAVLES
.....|.||...||| .||.|. .|.|| 
aveelraqrpgavqteeqylflyeallel
subfamily_Ptp69D_pd Subfamily Ptp69D 1320-1583 3.6e-53 175.7 In-house 20-289 (307) alignment 
Range on Protein: 1320-1583
Range on HMM: 20-289/307.0
GRTGFIDQFTVLEQVtQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLK----GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
   |..  .  ||.  . . . .      |. |||. .  . |..|| ||     |. ||||| ||.|||||| ||.|  |. .|. .||.|| . .|| 
tdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtl

IVMLCHEKEIDQEVCYQYWPSTpSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTN-----TGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRR
||||  ..| ... | .|||        |.  . | |||  . ||.|.|.| ...        .. |.||. |.|  .     ....| .||.... .. 
ivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

RgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
  .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  ||  .||. ... .| | .  
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1317-1584 3.3e-52 172.3 In-house 16-285 (288) alignment 
Range on Protein: 1317-1584
Range on HMM: 16-285/288.0
TKTGRTGFIDQFTVLEQVtQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRN
 ...|||| ... .| .. .. ..||    ..|..|||  . || |  || ||.    .  ||||| .|.|.|.||..| . .|. .|  .||... ...
sarnrtgfseeynsLaal.ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

VTAIVMLCHEKEIDQEVCYQYWPSTPSGLVIGEYAIMLSSEEIYNGYIERKLEVKntNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRg
.. |||| .  | ... | .|||..      |.  ..| ...  . ...|||...   ...   . ||| . |. .   .  . .| ... .  ..    
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL--DSFE
   |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||..||. |....|.    |. .
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgva
0037934 (Phosphotyrosine protein) phosphatases II 1346-1579 1.7e-51 170.5 In-house 7-241 (243) alignment 
Range on Protein: 1346-1579
Range on HMM: 7-241/243.0
ASQNNDKNRSTQFLPRDNYRVPLKGehPDYINAVFINGYKeKkaFIIAESPMFNTARN----FWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPstPSGl
  .| .||| . .|| |. || |.|   ||||| .|.... .  .|.   |. .|  .    ||.|. . ..|.||||....| ..| |.||||   .  
lpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.

VIGEYAIMLSSEEIYNGYIERKLEVKNTN-TGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRR-------RGNTSIVVHCSDTVGRSAMFCAA
..|.. . | ||| ...|. |.|...|.. .. |. |..|. ..|        |. .|. ..|... ...        ..  ..||||  |||.....||
tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaa

ATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTVQQYQGIFQIVLTY
 . . ..   | .|.....|  | |.|| .||| .||. . ...| .
ylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRG_pd Subfamily PTPRG 1320-1585 4e-51 168.9 In-house 17-292 (563) alignment 
Range on Protein: 1320-1585
Range on HMM: 17-292/563.0
GRTGFIDQFT-VLEQVTQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLK---GEH--PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
| .||  .|  . ......  ...|  . .|  ||| .. .. |. || |.   |..   ||||| .|.||. .||||..  |. .|.  ||.|| ..||
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

TAIVMLCHEKEIDQEVCYQYWPStPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQ------SVMQYQITNWVSTRKMAKPQTILSVIEEMyKT
. |||.   .|  .. | .|||.    . .|.  . | .||.   | .|.| .||..   ..       |.||. |.|  .    ..   |. ..   ..
aiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.sa

QRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
 ...    ||||||  |||. ....  | ... ..| ...||..||  | |..  |||  ||. .....|  . | ||
ankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1316-1582 2.2e-50 166.3 In-house 9-278 (281) alignment 
Range on Protein: 1316-1582
Range on HMM: 9-278/281.0
DTKTGRTGFIDQFTVLEQVTQRpDEVTHNIASQNNDKNRSTQFLPRDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDR
 ..   .||| ... |... .. .  |   | .|  ||| .     |. || .    . .. ||||| |..|||..|..|....|. ..  .||.|. ..
lsqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

NVTAIVMLCHEKEIDQEVCYQYWPSTPSGLVIGEYAIMLSSEEIYNGYIERKLEVkNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRR
.|.||||. .| | ..  |..|||   | | .|.. .   .||  . |||||... ....| |..| | . |.|  .   |... .|.  .|..|.....
kvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekk

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
 ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||| ||. ....|| .|| 
tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
0041856 (Phosphotyrosine protein) phosphatases II 1057-1299 2.3e-50 166.1 In-house 1-177 (182) alignment 
Range on Protein: 1057-1299
Range on HMM: 1-177/182.0
NRPLNRFGNIVVYDDNRillnqipgntdcQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTnlkedttikCHQYWPehgstsy
|...||. .|. || .|             .||||| ...|.  . ..||||||  .|. ||.|......  .||..|         ...|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

gpfrieltkeqvltdytirkmqltllgsDQPPLMITQYHFTSWPDHGVPEyATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQaeke
                            .  . ...||....|||||||.   ..|.| .....     .|| |||||||||||||. |... ...    
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....

gGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQ
 |... .... .|..|..||.| .||.|. .|.|| . ...|.
.gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_PTPRB_pd Subfamily PTPRB 1318-1582 1.2e-49 163.9 In-house 21-287 (293) alignment 
Range on Protein: 1318-1582
Range on HMM: 21-287/293.0
KTGRTGFIDQFTVLEQVTQRpDEVTHNIASQNNDKNRSTQFLPRDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNV
.   ..| ...  |..| .   .|. . ...|..||| |. || |. || |    . .. ||||| .|.||. .. || .  |. .|  .||.|. ....
adsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekks

TAIVMLCHEKEIDQEVCYQYWPSTPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNtnTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQ-RRRG
..|||| .  |  .. | .|||.. .  . |.  . | .|| .. .. |.|....  . ....|.||. | |.      |..|.|. .... ... .   
siivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektas

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
.. ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||..||  | | ||..| .
krPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1060-1290 1.8e-49 163.1 In-house 41-274 (287) alignment 
Range on Protein: 1060-1290
Range on HMM: 41-274/287.0
LNRFGNIVVYDDNRILLNQIPgntDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEH-GSTSYGP
 ||..... .||.|.|| . .   .   ||||| |. .| .| ..||.|||.. |. ||||.....|  .....|   |..  ||..||||.      | 
knryadvlPiddtrvllsaeg...elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGG

FRIELT-KEQVLTDYTIRKMQLTLLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-----KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
. . |  ...   .|..| ..|  | . .   .. |... ||||....  | ....|   .|.           ||..||...|.||.|...|. . ...
ysvvlldydikePeygvralrlidletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr

AEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVL
 |. | .|.  .. ..|..|  .||.. |. .. .|. 
ledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPN23_pd Subfamily PTPN23 1319-1580 1e-48 160.6 In-house 12-280 (288) alignment 
Range on Protein: 1319-1580
Range on HMM: 12-280/288.0
TGRTGFIDQFTVLEQVTQRP-DEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEHPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAI
 |.|..  .|  |||  ..   . .  ||  . .||||.  || |. || |.|.. ||||| |...       ||.. .|. .|.  ||.|. .. .  |
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssvi

VMLCHEKEIDQEVCYQYWPSTP-SGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEE---MYKTQRRRG
||| ...| ... . .|||.      . |.. . |.|..  . ..||.|...  ..  ..||.  |.|.| .    | |.|.| ...|   .|....|. 
VmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrks

NTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||...|..  ...||.. 
ktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPN12_pd Subfamily PTPN12 1318-1580 2.2e-48 159.6 In-house 4-277 (290) alignment 
Range on Protein: 1318-1580
Range on HMM: 4-277/290.0
KTGRTGFIDQFTVLEQVTQRP--DE---VTHNIASQNNDKNRSTQFLPRDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMI
|.|.  |  .|. | .....   ..    ..  ...|  |||    || |. || |.     |. ||||| ||.| ..|...| | .|. .|  .||.||
kegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmi

DDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLV-IGEYAIMLSSEEIYN-GYIERKLEVKNTntGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYK
.. ||. .||.|.| |...  | .|||..    . .||. . |..|.  . ... | |.|..   . ...| |.. |.|      ......|..||.. .
weknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvre

TQRrRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.|. . .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  ||| .||. ... |. ..
lqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1347-1585 6.3e-48 158.4 In-house 49-289 (297) alignment 
Range on Protein: 1347-1585
Range on HMM: 49-289/297.0
SQNNDKNRSTQFLPRDNYRVPLKG--EH--PDYINAVFINGYKEkkAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQeVCYQYWPSTPSGLv
  | .|.| .  || |  || |.   ..   ||.|| |..|.|.   .|  . || .|  .||.|. | .|..|||| ...| |.  | .||. . .   
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.

IGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMA--KPQTILSVIEEMYKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTINKC
 |. ...|.| .  .|.|.|.|||.. .. ... | ||| ..| .       . ...| .|.|. |.   . .. ..|||.  ||| .....    . . 
fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaea

KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSFET
| |  .|.|...|  | ..|  ||| .||. ....|| .| | .|
krekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_PTPRK_pd Subfamily PTPRK 1347-1578 8.1e-48 157.8 In-house 41-275 (314) alignment 
Range on Protein: 1347-1578
Range on HMM: 41-275/314.0
SQNNDKNRSTQFLPRDNYRVPL---KGE-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGlv
 .|..||||.. |. |. || |   .|. . ||||| .|..||  .|||..  |. .| ..||... | | ..|||| . .|  .  |..|||   .   
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..

IGEYAIMLSSEEIYNGYIERKLEVKN--TNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRrGNTSIVVHCSDTVGRSAMFCAAATTINKC
 |.  ..| . |. . .. | . |..   .   .. | |.| ..| .     . ...|... .. |.|   ..  ||||||   ||. .|.| .. ..  
ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmi

KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
..|||.|||.. |. | .|.  |.| .||. |....| 
eregvvdvfnavktlrsrkvnmveteeqykfiydvile
0036282 (Phosphotyrosine protein) phosphatases II 1087-1287 1.9e-47 156.5 In-house 2-164 (174) alignment 
Range on Protein: 1087-1287
Range on HMM: 2-164/174.0
NDYINACYIDGYSQDYKYIATQGPVTktlvdFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEhgstsygpfrieltkeqvltdytirkmqltllGSDQ
.||||| ..|..    ..||.||| .     ||.......  ..||....||.   ||..||||                                 .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

PPLMITQYHFTSWPDHGVPEYATsILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEkEGGIDIISIINKMRQQRMKMVQTADQYIFV
.  .. ||... |||||||. .. .|.| ..... ..   .||.|||||||||||||..|... |.. . |. .|..... ..|.||..|||| .||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

ND
 .
yy
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1321-1578 1.2e-46 154.2 In-house 23-277 (315) alignment 
Range on Protein: 1321-1578
Range on HMM: 23-277/315.0
RTGFIDQFTVLEQVTQRPDEVTHNIasQNNDKNRSTQFLPRDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
. || ...  .     .| .|...|  .| .|||  . .. |. || |    . .| ||.|| ||.||. |. .| |..|  .. ..||... . ... |
kngfkqdyesipggqlhpldvakki..enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigki

VMLCHEKEIDQEVCYQYWPSTpsGLVIGEYAIMLSSEEIYNGYIERKLEVknTNTGSTQSVMQYQITNWVsTRKMAKPQTILSVIEEMYKTQRRRGNTSI
|||    | ... . .|||     .. |.... . |||... |  | | |  .     . |.|...| |  . ...|  . |  .    |  .    ..|
vmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsv..vfgdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsvgai

VVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
|||||. |||.  |..  . ... ..| .|||.....  | .. . ||...||| |....| 
vvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPN6_pd Subfamily PTPN6 1310-1582 6.7e-46 151.7 In-house 14-299 (306) alignment 
Range on Protein: 1310-1582
Range on HMM: 14-299/306.0
NRMSKPDTKTGRTGFIDQFTVLEQVT-QRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLK---GEHPDYINAVFINGY--KEKKAFIIAESPMFNTARN
....| .......|| ..|  |.|   ..  . ..    .|. |||    || |. || ||       ||||| .|..   ...|..| ..  . .|  .
selekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsd

FWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLVIGEYAIMLSSEEIYNGYIERKLEVK-NTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIE
||.|. . | . |||. .| |  .| |..|||.. .    |.. ..  ||.  . || |.| |. ... .....|.||. ..|      ..|...|. .|
FWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfle

EMYKTQRRRG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
.. . |..     . .||||||. .||   |    . ... ...|.   ||. .. || | |. | ||| |||. ..... .|...
dvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1317-1581 7.8e-46 151.2 In-house 12-277 (515) alignment 
Range on Protein: 1317-1581
Range on HMM: 12-277/515.0
TKTGRT-GFIDQFTVLEQVTQRPDEVTHNiaSQNNDKNRSTQFLPRDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDR
.| ..|  | ..|  |      |. |. .    |  |||    || |. || |       | ||.|| .|....  ||.| .  |   .  .||... . 
nknrhttlfseefhdlpgpniypqtvaqe..einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqe

NVTAIVMLCHEKEIDQEVCYQYWPSTPSGLV-IGEYAIMLSSEEIYNGYIERKLEVKNTNTgsTQSVMQYQITNWVSTRKMAKPQTILSVIEEMyKTQRR
|||.|.|. . || |.  | .|||  |.  |  |.. . | | |   | | |||.|   .   .. | |.. |.|       . ...| .| |. |... 
nvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikev.kadhg

RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
. . ....|||  |||  .....   . . ||  ..|||....  | ..|  ||| .||  |...|| .| 
qythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1321-1582 9.5e-46 151.4 In-house 22-290 (325) alignment 
Range on Protein: 1321-1582
Range on HMM: 22-290/325.0
RTGFIDQFTVLEQVTQRPDevTHNIASQNNDKNRSTQFLPRDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNvTAI
. ||  .| .|  .       .     .| .|||    .. |. || |.      . ||||| ... .|.|. |. | .|. .|  ..|... | . ...
qdgfahefgllpsddgiak..kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csv

VMLCHEKEIDQEVCYQYWPST-PSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYK---TQR--R
|..  | . ... | .|||         |   . | . | .  |. |.|.||... | |.|| |.|.  |       .| |..|... . .   . .   
vvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtant

RGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
.. | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.|| ||  |.. .  .. |
kastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1345-1581 4.5e-45 148.8 In-house 40-278 (315) alignment 
Range on Protein: 1345-1581
Range on HMM: 40-278/315.0
IASQNNDKNRSTQFLPRDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPS-
  ..|  |||    || |. || |    .  . ||||| .|..... ||.| .  |   .  .||.|. . .||.|||. . .| |.  | ||||   . 
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

GLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTgsTQSVMQYQITNWVSTRKMAKPQTILSVIEEMyKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTINK
    |.. . | | |   . . ||| ......  .. | |.| |.|       .  ..| .| |. |..... . |..||||  |||. .....   ...
svefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikev.kadngkkefsllvhcsaGvGrtGvvisidevvaq

CKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
 | . ..|||...|  | ..|  ||| ..|  |...|| .| 
ikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1320-1577 3.1e-44 146.6 In-house 32-288 (319) alignment 
Range on Protein: 1320-1577
Range on HMM: 32-288/319.0
GRTGFIDQFTVLEQVTQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTA
 .| .  .|  . ...    . |.    || |||| .. |. |. .| |.   | |  ||||| |..||. |. .| |  |. ||  .||.|| . |...
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IVMLChekeidQEVCYQYWPSTPSgLVIGEYAIMLSSEEIYNGYIERKLEVKN-TNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEE-MYKTQRRRGN
||.|       .. | ||||        ... . ..| |  . |. |..|. . ..    ... |. .  |    .   |  .. ...   . |.. ...
ivllt......kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
..||||||  |||. .. .  . ... | |  .||.....  | |..  || . ||. |.  .|
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1340-1577 4.4e-44 146.1 In-house 16-252 (284) alignment 
Range on Protein: 1340-1577
Range on HMM: 16-252/284.0
EVTHNIASQNNDKNRSTQFLPRDNYRVPLK---G-EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChekeidQEVCYQYWP
. |.    || |||| .. |. |. .| |.   | |  ||||| ||.||. |. .| .  |. ||  .||.|| . |...||.|       .. | ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

STPSgLVIGEYAIMLSSEEIYNGYIERKLEVKN-TNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEE-MYKTQRRRGNTSIVVHCSDTVGRSAMFCAA
        ... . ..| |  . |. |..|. . ..    ... |. .  |    .   |  .. ...   . |.. .....||||||  |||. .. . 
lkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

ATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
 . ... | |  .||.....  | |..  || . ||. |.  .|
dvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1347-1581 5.3e-44 145.4 In-house 26-269 (274) alignment 
Range on Protein: 1347-1581
Range on HMM: 26-269/274.0
SQNNDKNRSTQFLPRDNYRVPLKGE-----HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSG
. .. ||| .. || .| || |. |       .|||| .| ||.| .||.. .  |. ||  .||.||  ..|. |||| . || ... | .|.| . . 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

LVIGEYA---IMLSSEEIYNGYIERKLEVKNTNTgsTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGNT--SIVVHCSDTVGRSAMFCAAAT
 . ..|    |  ..    |.|  ||| .|...   ..||. |  |.|  ..   ...|.|....|. ...... .   ..|||||  .||  .| |.  
eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

TINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
.... . |.|.||...    |... | ||| .||. |....  || 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0046846 (Phosphotyrosine protein) phosphatases II 1085-1290 1.8e-43 143.6 In-house 10-170 (176) alignment 
Range on Protein: 1085-1290
Range on HMM: 10-170/176.0
CQNDYINACYIDGYsqdyKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYgpfrieltkeqvltdytirkmqltllgs
   ||||| .|.|.    ..||||||. .|| ||........  ..|..|...|   .||..||||  . ..                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

dqpplmitQYHFTSWPDHGVPEYaTSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDmglqQAEKEGGIDIISIINKMRQQRM-KMVQTADQYI
        ||... |||||||.. . .|.. . |.. .|   || |||||||.|||||. |..      |.| |...  .. ..|.||. ..||| .|| 
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

FVNDAVL
|. ...|
flyefel
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1324-1578 6.3e-43 141.7 In-house 8-257 (267) alignment 
Range on Protein: 1324-1578
Range on HMM: 8-257/267.0
FIDQFTVLEQVTQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEk
.  .|  ......    ..  ||..|...||  . || |. ||.|. .  .|||| ...||| |.|||. . |. ||  .|...| |..|. ||.| .  
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv.

EIdQEVCyQYWPS-TPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTgSTQSVMQYQITNWVSTrKMAKPQtILSVIEEMYKTQRRRGNTSIVVHCSD
 . ...  ..||          . ..  | |.  | |    ||.|  |  |.. |  |   .|       ||  .  ..  . | |   ||  .||.|||
ft.dnir.lfwPPkmgqakkyqdltvehslekeendyqiitlelkfkne.sahnvtlyyykkwnin.tnnkpy.lkplfgilaknqlengnrPlvvacsd

TVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
 ||||  |  . . ... ||||| |.|. |.  | |..| |.| ..|  | ...  
GvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_PTPN3_pd Subfamily PTPN3 1341-1577 6.9e-43 141.6 In-house 33-272 (280) alignment 
Range on Protein: 1341-1577
Range on HMM: 33-272/280.0
VTHNIASQNNDKNRSTQFLPRDNYRVPLKGEHPDYINAVFIN----GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPS
...   ..| .|||    || |. || || .. ||||| ..|    . .  . .|..  |. .|| .||.|. ..... ||||    |  .  |.||||.
isaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

TPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMyKTQRRRGNTSIVVHCSDTVGRSAMFCAAATT
|   |  ||. .....|.  . |. |.| .|...|   ....| | ..|       ... .|...|.. ...|.  .. .|||||  .||. .. .  |.
tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv.rklrsgkeePvvvhCsaGigrtGvlilleta

INKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
. .  ..  . . ....  | |.   |||..||. . . .|
lalieaaepvypldivrtmrdqramlvqtasqykfvCeail
0043147 (Phosphotyrosine protein) phosphatases II 1086-1285 7.4e-43 141.6 In-house 4-153 (172) alignment 
Range on Protein: 1086-1285
Range on HMM: 4-153/172.0
QNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLkedttikchqywpehgstsygpfrieltkeqvltdytirkmqltLLGSD
 .||||| |.|.|    ..||||||   || ||||.....   .||..|.|                                            |.  .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpe

QPPLMITQYHFTSWPDHGVPeYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINKMRQQRMKMVQTADQYIF
.   .. ||....|||||||  .  .|.| . |..   .  .||.|||||||||||||. |... |       |...  ... .|..|...||. .||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

V
.
l
0049772 (Phosphotyrosine protein) phosphatases II 1046-1294 4e-42 140.4 In-house 35-281 (314) alignment 
Range on Protein: 1046-1294
Range on HMM: 35-281/314.0
EHSVTIAVTPSNRPLNRFGNIVVYDdNRILLNQIPGNTdcqNDYINACYIDGYsqdYKYIATQGPVTKTLVDF----------WRLI--WQERPPVIVM-
|.....|  . ||  ||. .|. .| ||  |.  |...    ||||| |.||.    |.||||||   |.|||          ||..  .. .. .||| 
eltilvadlflnrdknryldilpad.nrvilpglpvsg...sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------VTNLKEDTTIKCHQYWPEHGstsygpfrieltkeqvltdY-------TirkmqltllgsdqpPLMITQYHFTSWPDHGVP
                     ..| . . . . ......                                           . .. .|. . .||...|
rdevladelsrLdaAlgKtpllildgngneptaadlellk...................eelydpelf..............erlgikylripvpDgsap

eYATSILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAekegGIDIISIINKMRQQRM-----KMVQTADQYIFVNDAVLESVT
     ...| . |..   ...|| ||||.||.||||||..... . .     |...  ... .|..|.      .... .||.|. .|.|| . 
.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
0049260 (Phosphotyrosine protein) phosphatases II 1094-1286 5e-42 138.5 In-house 1-143 (152) alignment 
Range on Protein: 1094-1286
Range on HMM: 1-143/152.0
YIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWpehgstsygpfrieltkeqvltdytirkmqltllgsdqpplmitQ
.|||| . ...||||||   || ||||....    .|||.|.| |.. .||.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINKMRQQRMKMVQTADQYIFVN
|... |||||||. .  .|.... |.  ..  .|| |||||||||||||..|... |       |...  ... .|..|...|.. .|..|. 
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1049-1291 8.8e-42 137.9 In-house 25-257 (267) alignment 
Range on Protein: 1049-1291
Range on HMM: 25-257/267.0
VTIAVTPSNRPLNRFGNIVVYDDNRILLNqipgntDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTtIkcHQYW
..  ..  |.  ||. . . |||.|. |       . ...|||| |..|| .  ..|.||.|. .|  ||. .| ... ||||..|.  .|  |  ...|
isqsiaeknqernrlddnlpyddtrvilr......tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn.i..rlfw

PEH--GSTSYGPFRIELTKEQVLTDYTIRKMQLTLlgSDQPPLMITQYHFTSWPDHGVPE-YATSIlqFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMA
| .   .  |  . .| . |.   || |  ..| .   ..    .| |..  |      . |   .  |    ||. .    |..|.||.||||.|||. 
PPkmgqakkyqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrsGtflv

IDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
||  |..| .||  ||   . |.|.||. .|.| ..||.. . . |
idsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_PTPN13_pd Subfamily PTPN13 1327-1582 1.5e-41 137.5 In-house 16-271 (273) alignment 
Range on Protein: 1327-1582
Range on HMM: 16-271/273.0
QFTVLEQVTQrPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEHPdYINAVFINGY--KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKE
.|. |...    |...     .|.||||  . || |. ||.|..| . |||| .|.    |..  .|..  |. .|...||.|. ..... |.|. .|||
efkelrelkp.ldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtleke

IDQEVCYQYWPSTPS-GLVIGE-YAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRrrGNTSIVVHCSD
 ..  | .|||.. .  |.. . . . |   . ..|.  |.|.||....| .. |.. . ..|      .... .| .. |. . |.   .. |||||| 
kgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsa

TVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDS
 .||| .. .  . ..  . .  .|| ..... | |. | ||| .||  .....|. | |
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1060-1291 1.7e-41 136.8 In-house 59-281 (290) alignment 
Range on Protein: 1060-1291
Range on HMM: 59-281/290.0
LNRFGNIVVYDDNRILLNQipgntDCQNDYINACYIDGYSQdyKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGS--TSYG
 ||. ..|  |  |..|..       . ||. | |..|      .| |||....| .|.||.. ||.  .|||. .| ||   ||.||.||.     ..|
knrykdvvcndktrvilkd.....GydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

PFRIELTKEQVLTDYTIRKMqLTLLGSDQP-PLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE
 . .  ..|.   . .|.|. |..   |.    ..  ..  ||||. |.  . ..|.  | ...    . ||. ||||||.||||||.||..|||   . 
eitvlcseeddkdaniikkt.lsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldG

GGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
  .|.. ..  .|. |.. ||   ||. . ...|.
keldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_PTPN9_pd Subfamily PTPN9 1319-1580 1.7e-41 137.2 In-house 13-290 (297) alignment 
Range on Protein: 1319-1580
Range on HMM: 13-290/297.0
TGRTGFIDQFTVLEQVTQRpDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKG----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
.|. | . ... . . .    ....     |  ||| |  |  |. || |.     |. ||||| |..|||.||||| .  |. .| ..||.|. ...| 
kgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevl

AIVMLCHEKEIDQEVCYQYWP-STPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQR----
 |||  .  |  .  | |||| .. |    |.. .   . | .. | .|.||.||..|. ...|. .|.. |         ...| |.|.. ..|     
vivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavk

-----RR---GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
      .    .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.|| .||.  .. || | 
elgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_CG7180_pd Subfamily CG7180 1339-1580 5.8e-41 135.0 In-house 32-290 (296) alignment 
Range on Protein: 1339-1580
Range on HMM: 32-290/296.0
DEVTHNIASQNNDKNRSTQFLPRDNYRVPLK---GE-HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQeVCYQYW
..  ... ..| .|||  . .| |. || |.   || . ||||||.....  ||..|. | |. .|  .||... |... |.|.|... .  .  . .||
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PSTPsGLVIGEYAIMLSSEEIYNGYIERKLEVKNT----------NTGSTQSVMQYQITNWVSTRKMAKP-QTILSVIEEMYKTQRRR----GNTSIVVH
| .      ||  . . .|. |     |.. .. .           .  |  |...|.| | .  |.    .... ... . . ...      .  .||.
pnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.|| ..|| ...|.  .... . |. .|||. .|  |...|. |..|..|. |....| ..
ssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1345-1581 8.9e-41 134.6 In-house 16-265 (270) alignment 
Range on Protein: 1345-1581
Range on HMM: 16-265/270.0
IASQNNDKNRSTQFLPRDNYRVPLKGEHPD----YINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPS
 | ...  ||... ||  . || |. .. |    |||| ...|... ||..| | .|. .| ..||.|| ...||||||. . .|  .. | .|||. | 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

G---LVIGEYAIMLSSEEIYNGYIERKLEVKntNTGSTQSVMQYQITNWV------STRKMAKPQTILSVIEEMYKTQRRRGN-TSIVVHCSDTVGRSAM
    |  |. ... .|||  .||| ..|...  ..|... .. .. ..|       .. .  ... .|...... .....  . . ..||||. |||. .
ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

FCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
. |  ....  .... .|| ....  | ...  ||...||. ... |..| .
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1019-1291 2.4e-39 129.9 In-house 10-285 (305) alignment 
Range on Protein: 1019-1291
Range on HMM: 10-285/305.0
GEFVANGHAKGNEGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLnqipgNTDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDF
 .|| .   || .|..... ...  .. . .       ..  ||. ..   |.||. |     ..    .|| | |.   ..  ..| || |. ||  ||
lkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl.....egpwpheyihanyvstptnpkrfictqaplektcadf

WRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTS----YGPFRIEL----TKEQV---LTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEY
| . .|..   | |. ||.|  . ||..|.. .         .  .| .    ...      .. .... .|.. |. .  . .|.||.  ||| |||  
wymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaa

ATSILQFHRriknEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID-IISIINKMRQQRMKMVQTADQYIFVNDAVLE
 ..||..      . .|.|||. ||||||.||||. . ..  |.|      |.    |..|.|.|| . .|| .||.|| . .|.
dlailelle....karpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1031-1291 1.8e-38 126.8 In-house 11-267 (281) alignment 
Range on Protein: 1031-1291
Range on HMM: 11-267/281.0
EGFKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQ-IPgNTDcQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPV
. ||...  |        .|.   | |   ||. || . |  |. |.  .| | .   ||| | ||        || ||||  .|  ||||.||||    
ddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmp.nkn.stdyihanyirspflkrgyiltqgpkketradfwrmiwqentta

IVMVTNLKEDTTIKCHQYWPEHGSTS--YGPFRIELTKEQVLTDYTIRKMQLTLLGSdqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkg
|||. .. |    || .|.|        .  . ..     |       ...|.  |      .||.. .  |||  ||| .  .|.  |.|.        
ivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyege...trlithwlwkewpdwqvpessevmlkilrkirarst....

PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINKMRQ-QRMKMVQTADQYIFVNDAVLE
| ..||||||||.||.||... ||       . ||  |. ..|   |   ||| .||...   .|.
ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_PTPN1_pd Subfamily PTPN1 1343-1575 1.8e-38 127.0 In-house 24-266 (290) alignment 
Range on Protein: 1343-1575
Range on HMM: 24-266/290.0
H--NIASQNNDKNRSTQFLPRDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPS-
.      .|...||     | |  |. |. .. ||||| ...  . |. .|..  |. ||.  ||.|. ...  |.||| .  | .|  |.||||.  . 
treaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeee

-GLVIG--EYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRR-RGNTSIVVHCSDTVGRSAMFCAAAT
  |..   .. . | |||... |. |.||..| .|  |......  | |        |.. |. . .. ..    .     |.|||  .|||  || . |
kellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt

TIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQI
 .    | .    .|. .||   | .. | .|| .| .  .. 
clvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyla
0051082 (Phosphotyrosine protein) phosphatases II 1087-1289 1.4e-37 124.0 In-house 3-149 (151) alignment 
Range on Protein: 1087-1289
Range on HMM: 3-149/151.0
NDYINACYIDGYsqdykYIATQGPVTktlvDFWRLIWQERPPVIVMVTNLKEDTtiKCHQYWPEHGstsygpfrieltkeqvltdytirkmqltllgsdq
.||||. |..|.     .....||      ||..|....   .||......|    .|..|.||.|                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

ppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekeggIDIISIINKMRQQRMKMVQTADQYIFVN
  . ........|||.|.|..  ..|.|.. . .   . .||.|||||||.|||||..|... |..      ... .... .|..|. .||. .|..|. 
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DAV
 |.
fal
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1348-1581 1.5e-37 124.0 In-house 37-278 (287) alignment 
Range on Protein: 1348-1581
Range on HMM: 37-278/287.0
QNNDKNRSTQFLPRDNYRVPL--KGEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLVIG
 .  ||| .. || |. || |  .||.  ||||| .. .|....||| | .|.  | |.||... .......... .| |  .  ||.|||     . .|
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYAIMLSSEEIY-NGYIERKLEVKNTNTGSTQSVMQYQITNWvsTRKMAKPQ------TILSVIEEMYKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTI
 |...| . .|    |  | | . . .|  .. | |... .|    | . |        .|.| . .  ..   .   .|||..  .||| .. |  . .
GysvvlldydikePeygvralrlidletrearvvkqldllsw..PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

NKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
.. .  | .|| .|.   | .. . ||.| |.. ... . ||  
srledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_PTPRN_pd Subfamily PTPRN 1333-1576 2.6e-37 123.1 In-house 40-288 (297) alignment 
Range on Protein: 1333-1576
Range on HMM: 40-288/297.0
QVTQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGE----HPDYINAVFINGYKEK-KAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQ
.  . |   .   | .| .||||...|| |. || || |    . ||||| .|     .  |.| ...|. .|  .||.|. .. |. ||.|.. .| . 
ayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegv

EVCYQYWPSTPSGlVIGEYAIMLSSEEIY-NGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGnTSIVVHCSDTVGR
. |..||| . |  | . | . | || |. . |. | . .|| .|  |..| |.    | ..   |.....|     . |. | |  ..||||||| .||
kqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.cpivvhcsdGaGr

SAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIV
. ....    .|.  |    ||.   |.  | |.|| |.| .|.. ... |
tGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
PTPc_DSPc_SM00012 1191-1291 1.4e-36 120.2 In-house 2-105 (105) alignment 
Range on Protein: 1191-1291
Range on HMM: 2-105/105.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK--GPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINKMRQQRMKMVQTADQYIFVND
...||.|.||||||||...|||.. | .|....  .  .|..|||||||||||||.|.|. ||| ||| . .||  |....|.||..|||| .||.|. .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1029-1291 3.6e-36 119.7 In-house 14-275 (307) alignment 
Range on Protein: 1029-1291
Range on HMM: 14-275/307.0
GNEGFKNQYCTLNSgDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNqIPGNTdcqNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPP
| . .....  |    . ..||.    .|   ||. .. . | .||... ..| .    ||| | |.    .  |.|..|||  .|  .|| .. ||.  
gvqalvdefrvlak.ktpegvtveafsantdknryqdvkcqdkgrivvk.fdgla...sdyihanylgiaikpkkficaqgplentqysfwamaiqekve

VIVMVTNLKEDTTIKCHQYWPE-HGST-SYG--PFRIEL---TKEQVLTD-YTIRKMQLTLLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKN
 ..|. .. | . |||.||||  .| .  .|  |  | .     ...  |   |   .| .    |    |... .. |||.|||.   . . .   .. 
svimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvd.waqksrtiqhlqwenwpdrgvpqinltainlleavry

EykptKGPMLVHCSAGVGRTGTFMAIDMGLQQ-AEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLE
.    . |..|||||||||.|| .|| .  ..  . .   |.  .....|.||   .||  ||...   .||
d....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
0044763 (Phosphotyrosine protein) phosphatases II 1070-1287 3.9e-36 119.7 In-house 3-165 (178) alignment 
Range on Protein: 1070-1287
Range on HMM: 3-165/178.0
DDNRILLNQIPGNTDcqNDYINACYIDGYsqdyKYIATQGPvtktlVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGStsygpfrieltkeqvl
|..| ||. ..|      |||||..|...     |.....|     .|...|....   .||..|. .|   .||..||||  .                
drtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

tdytirkmqltllgsdqpplmiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekegGIDIISIINKMR
                       ||... .||||||.    .|.|.. |.. ... .|| ||||||||||.||..|... ...     |... ..|. .|
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

QQRMkMVQTADQYIFVND
..|. .|.. .|. .. .
erRp.ivpnpgqlrqLye
subfamily_PTPN14_pd Subfamily PTPN14 1328-1581 4.2e-36 119.5 In-house 26-297 (300) alignment 
Range on Protein: 1328-1581
Range on HMM: 26-297/300.0
FTVLEQVTQRPDEVTHNIA--SQNNDKNRSTQFLPRDNYRVPL---KGEHPDYINAVFING--YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLC
||  |.....  . . . |   .|..|||  ..|| .. || |   | .. .||||  |.     ... .|.| .|. .| ..||.|. . .|. |||| 
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

HEKEIDQEVCYQYWPST---PSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGNTS--
.|.|  .| ...|.|..    . .  |.. ..    |  . .| ..|..|   ..  ..|.  | |.|   .    ... || .||.   .|.  ...  
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

------IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
      ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. ||. .......||.
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0051429 (Phosphotyrosine protein) phosphatases II 1372-1583 5.2e-36 120.1 In-house 3-228 (272) alignment 
Range on Protein: 1372-1583
Range on HMM: 3-228/272.0
HPDYINAVFINGYKE---KKAFIIAESPMFNTARNFWKMiDDRNVTAIVMLCHEKEIDQEVCYQYWP-----------STPSGLVIGEYAIMLSSEEIYN
 ..|||| ...||     ..... .  |. .||..||..  . ....||.|..| |.... |..|||           ...    .| . ..| |||...
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

GYIERKLEVKNT-NTGSTQSVMQYQITNWVSTRKMAKPqtILSVIEEMYKtqrrrgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------V
 || |.|..... ..| .  ||... |.|.      ..  .|...|.. .      .  ..||||  ..|.....|.   .     | ..|        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
.....  | | ||.||| .||. .....| .|.|.
eeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1020-1290 1.7e-35 117.1 In-house 16-287 (310) alignment 
Range on Protein: 1020-1290
Range on HMM: 16-287/310.0
EFVANGHAKGNEGFKNQYCTLNSgDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNqIpgNTDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFW
.|.      | ||. .||  |.. ... |.|      .   ||. ..|. |. |. |. |  .    .||| | |.        .| .|||. .|..|||
nfiiateklgieglvkqyrklda.kqdssltyeaykkymhknrysdvvcldtsrvklk.i..dksryedyihanyvktnylrstficsqgplqhtiidfw

RLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGST-SYGPFRIELTKEQVlTDYTIRKMQLTLLGSD-----QP----PLMITQYHFTSWPDHGVPEYAT
|.|.|||   |... .  |.   ||  |||  | | .||  |.    |    .. | .. .|..  .     ||     | ..  ..  ||| |||.   
rmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc

SILqfHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVL
  .   .|.  . .  .|| .||||||..|... .|... ......   .|.  .. .....|.. .||  ||....   .
htv..pqrllaqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1050-1293 3.7e-35 116.3 In-house 28-270 (285) alignment 
Range on Protein: 1050-1293
Range on HMM: 28-270/285.0
TIAVTPSNRPLNRFGNIVVYDDNRILLNqipgNTDcqNDYINACYIDGYSQDY-KYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYW
| .   .|  |||. .. . .. |..|.    | |   ||| | ..    .|   ||.||||. .|| |||..|.||.   ..|.  | |    ||  |.
tytayeanpdlnryadvrcieetrvvlk....nhd..rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PEHG--STSYGPFRIELT--KEQVLTDYTIRKMQLTLL-GSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKGPMLVHCSAGVGRTGTF
||.      .| . | ||  ||. ..   .  . ..    .   || . . .   |||.  || |  ...... .|.  .| . |. |||||||||| ||
peklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatf

MAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESV
. ||    .  ..  |... |. .||  |.. ||.  |..|.   ..| .
vgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_ptpA1_pd Subfamily ptpA1 1056-1246 6.7e-34 112.3 In-house 46-249 (418) alignment 
Range on Protein: 1056-1246
Range on HMM: 46-249/418.0
SNRPLNRFGNIVVYDDNRILLNQIPGNTdcQNDYINACYIDGYSqDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEH----
 |   ||. ||.  .  |. |..|  .    .||||| ||||     ..|.||||. .|. ||||..|..|  .|||..   |.  ||| .||||.    
hntsknrytnilpvnhtrvqlkkiqdke..gsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

-------GSTSYGPFRIELTKE--QVLTDYTIRKMQLTLLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY---KPT---KGPMLVHCSAG
       |   .| . .|| .   .   .   |...||. |  .    ||||..  |||| .|...  . |. . | |      |.   . |..||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetr...ditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

VGRTGTFMAI
||||||| . 
vgrtgtfcta
0036282 (Phosphotyrosine protein) phosphatases II 1374-1574 1.7e-33 111.1 In-house 3-164 (174) alignment 
Range on Protein: 1374-1574
Range on HMM: 3-164/174.0
DYINAVFINGYKEKKAFIIAESPMFntarnFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPStpsglvigeyaimlsseeiyngyierklevknTNTGS
||||| .....   . .|.   |.      ||.|. . ..|..|||..||| . . |..|||.                                . .  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lredl

TQSVMQYQITNWVSTRKMAKPQtILSVIEEMYKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
.....||. ..|.       .. .|........ . . ..  ..||||  |||.....||   .   . |...|........| |.||.||| .||. . 
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Q
.
y
0041856 (Phosphotyrosine protein) phosphatases II 1349-1579 6.5e-33 109.2 In-house 1-170 (182) alignment 
Range on Protein: 1349-1579
Range on HMM: 1-170/182.0
NNDKNRSTQFLPRDNYRvplkgeHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLChekeidqevCYQYWPstpsglvigeyai
| |||| . .|| |. |      ..||||| .. |.   . ||..  |. .|  .|..|. ....|.||.|.         ...|||             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

mlsseeiyngyierklevkntnTGSTQSVMQYQITNWVSTRKMAkPQTILSVIEEMYKtqrrrGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvIDV
                      .  .. ..||. ..|        ....|. |||...      .  ..||||  |||.....||   . .    | ...
......................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsl

FQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
....|  | ..||.|.| .||. . ...| .
eeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1029-1295 9.2e-32 105.2 In-house 17-273 (288) alignment 
Range on Protein: 1029-1295
Range on HMM: 17-273/288.0
GNEGFKNQYCTLNSGDNEHSVTIAVTPSNRplNRFGNIVVYDDNRILLNqipgnTDCqNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPP
. || | .|     . ......  .. . |  .|. |.   |  |. |.      |. . ||.|  .     . . | .| |.  |.  .|... ..   
aveglkkeyrdspneasidiidsfianptr..dryenlprcditrvkls.....ddp.dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdve

VIVMVTNLKEDTTIKCHQYWPEH-GSTS-YGPFrIELTKEQVltDYTIRKMQLTLLGS---DQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK
 |||...| |    |  .|.| . | .  .| .    .|..   .   . ....||      . . .. . |.  |.|.||||   | |..  ..|.  |
yivmlcellekGkeksaeyfPsklGekarigrl.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk

ptkgPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTC
    |..||.|||||||||.. | . |...  .  . | |...|.|..|.| .||  ||..|   ||| .  
....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1348-1577 1.6e-31 104.4 In-house 2-236 (237) alignment 
Range on Protein: 1348-1577
Range on HMM: 2-236/237.0
QNNDKNRSTQFLPRDNYRVPLKGE--HPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLVIG
.|. |||  .    |  || |||     ||||| ...|.    | .| |. |. ..  .||.|. . . . ||||    | ... |..|||||      |
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

EYAIMLSSEEIYNGYIERKLEVKNTNT-GSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKT
 ... |  .| .  |  | | . .  |    . . |||.| |       .  ..|    .. .  .     .  ..|||  |||...|    . . ..| 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

EGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
. |.|... ..|   ..|  .|| .||  |.| .|
kkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1191-1325 6.5e-31 102.1 In-house 91-226 (440) alignment 
Range on Protein: 1191-1325
Range on HMM: 91-226/440.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAV
. |||. .|||.|||..|  .|.. . ... . |  .||.|||||||.||||  .|.|  |..|..   |||.|.|| ||..| .|||| .|| ||..||
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

LESVTCGNTQVDSRNARIVFNRMSKPDTKTGRTGFI
||.. ||.| .   .     ...  |. .| .. . 
legllcgdtliledditerveqiqwpnphtdksplq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1342-1583 1.1e-30 101.3 In-house 47-286 (290) alignment 
Range on Protein: 1342-1583
Range on HMM: 47-286/290.0
THNIASQNN--DKNRSTQFLPRDNYRVPLK-GEHPDYINAVFINGYKekKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTP
  .|  .|    |||  .    |  || || | . ||. | ...| |    ||... .. .|. ..|.|. . .|.||||||   |  .  | ||.| . 
erkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke

S-GLVIGEYAIMLSSEEIY-NGYIERKLEVKNTNTGSTQSVMQYQITNWVStRKMakPQTILSVIEEMYKTqrRRGNTSIVVHCSDTVGRSAMFCAAATT
   | .||.... | |.   .  | . | |.. ..|    .  ..|  |   . .  ... |...  ..    |. .  .|||||  .||.  | |  ..
GevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpd.ksv..alstlallrtlril..rkasGpvvvhcsaGiGrtGtfvaievg

InKCKTEG-VIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLDSF
. .. ..|  .|. .. .. |  . .|||   ||  . .|.| .  .|
l.qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1089-1285 2.7e-30 100.2 In-house 77-273 (301) alignment 
Range on Protein: 1089-1285
Range on HMM: 77-273/301.0
YINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGST--SYGPFRIELTKEQVLTDYTI--RKMQLTLLGS
 | | .|.   .  ..||||||...|  ||| .. |     |||...  |... ||..| | . |     | |.|........ .  |  |.....    
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

DQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIF
. ..  .| | ...|.|.|||.  . . ..   .|.    .. |..||||||.||. .|.. ..  .. | .  |..   ....|..| . |||  |  .
kfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlyw

V
.
m
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1326-1580 3.5e-30 99.7 In-house 24-236 (392) alignment 
Range on Protein: 1326-1580
Range on HMM: 24-236/392.0
DQFTVLEQVTQRPDEVTHniASQNNDKNRSTQFLPRDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
..|  | .    |. |..     |  |||  . || |. || |       . ||.|| .|.... .||.| ...|   .  .||.|. . |||.|.|. .
eefhdlpgpdiypqtvaq..keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtk

EKEIDqevcyqywpstpsglvigeyaimlsseeiyngyierklevkntNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMyKTQRRRGNTSIVVHCS
 || |                                           .  ....| |...|.|       .  ..| .|.|. |..  .    ...|||
lkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcs

DTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
  |||...  .  . . ..|.  ..|||...   | ..|  ||| .||  |.  ||  |
agvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1320-1587 7.5e-30 99.0 In-house 14-286 (307) alignment 
Range on Protein: 1320-1587
Range on HMM: 14-286/307.0
GRTGFIDQFTVLEQVTqrPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLK--GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIV
| . ..|.|.|| . |  |. || .  | |.|||| ..   .|. |. .|  |   ||| | ..    . | || |. |. ||  .|| |. . .| ...
gvqalvdefrvlakkt..pegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvi

MLCHEKEIDQEVCYQYWPSTP-SGLVIGEYAIMLSSEEIYNGYIERKL---EVKN---TNTGSTQSVMQYQITNWVStrkMAKPQTILSVIEEMYKTqrR
|||.  |. .  | ||||      || || .  .| ...  . .       .| .     .. .... ..| .||        ||. |. |. .  .  |
mlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpd...rgvpqinltainlleav..r

RGNTSIVVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL-DSF-ETYS
  .  .|||||  ||||    | .   .|  . .   |. ....  | |.. ..||  ||  . ...| |. . . ||| 
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketye
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1060-1290 2.5e-29 96.9 In-house 58-286 (305) alignment 
Range on Protein: 1060-1290
Range on HMM: 58-286/305.0
LNRFGNIVVYDDNRILLNQIPgntdcQNDYINACYIDG-YSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGS---TS
 ||. .. . | . ..|.. .       ||| | |.      . ..|..|||. .|. .|| .. |..   |||. .  |   .|| ||||       . 
knryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

YGPFRIELTK-E-QVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQ-
 .   .|       .  |  |.   | |  | .  . . . ..| ||| |||    . |..   |.     .| |..||||||.||||| .||.  |.. 
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaieyileki

AEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVL
||.     .  ... .|.||   .|.  ||.|.   .|
aenkpcppmpelvkalrdqrafsiqndvqylfihrvml
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1044-1215 3.1e-29 96.8 In-house 20-190 (297) alignment 
Range on Protein: 1044-1215
Range on HMM: 20-190/297.0
DNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGntdcQNDYINACYID--GYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTT
 .  | . |  .|    ||. .|. .||.|. | . .     ..||||| |.      .|.||| .|||. .|. |||.|....   |||||..|.||  
argesfssakrnsslrknryrdilatddtrvkllrvit....erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

IKCHQYWPEH--GSTSYGPFRIELTKEQVlTDY-TIRKMQLTLLGSDQpPLMITQYHFTSWPDHGVPEYATSILQFH
 ||  |||.   .    | . .|   .    .. ..   .|.|.  ..   ...   | ||||||||     . .|.
dkcapywpsvvqerlkagdvvveflssts.defdrviltelqliyrse.srvvrhvqflswpdhGvpsdledlvrfq
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1335-1569 6.2e-28 92.4 In-house 36-270 (301) alignment 
Range on Protein: 1335-1569
Range on HMM: 36-270/301.0
TQRPDEVTHNIASQNNDKNRSTQF--LPRDNYRVPLKGEHpDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQ
|   |..|.  |  ..||.|  .    |    .|  .|.    | | .|.   . . ||.. .|. ||. .|| |.   .|  ||||... |  .|.| .
tidkdhitesyaylpkdkhryptvPckPstavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekcee

YWPST-PSGLVIGEYAIMLSSEE-IYN-GYIERKLEVKNTN-TGSTQSVMQYQITNWVStRkmAKPQTILSVIEEMYKTqrRRGNTSIVVHCSDTVGRSA
| |.. .. | || . | . ..| | |   ..|.|||...    .|..|. || ..|   |    |..   . . |     .. .  ||||||. .||| 
ylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtd.r..gvPkshaelfdlmelv..kksekPivvhcsaGiGrsv

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQY
 | ..    .. ...  |.. . ||  | ..  .|||..| 
afigteylareveadptieltealkhlrehrwngvqtnsql
0043147 (Phosphotyrosine protein) phosphatases II 1371-1573 1.6e-27 91.7 In-house 3-154 (172) alignment 
Range on Protein: 1371-1573
Range on HMM: 3-154/172.0
EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEkeidqevcyqywpstpsglvigeyaimlsseeiyngyierklevKNTN
|. ||||| ....|   . ||.   |. ||   ||.|. ....|.||.|. .                                             .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

TGSTQSVMQYQITNWVSTRKMaKPQTILSVIEEMYKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVQQY
.. .....||. ..|        .. .|...| ... . .. .  ..||||  |||.....||   .        . .......  | ..||.||. .||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqy

QGIF
. . 
rfly
0048076 (Phosphotyrosine protein) phosphatases II 1166-1289 2.8e-27 90.5 In-house 22-139 (145) alignment 
Range on Protein: 1166-1289
Range on HMM: 22-139/145.0
EQVLTDYTIRKMQLTLLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDMGLQqaekeGGIDIISII
 . | |. |.         . .  ...||....|||||||. .  .|.| . |.. .|   ||.|||||||||||||..|... |.      |... ...
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleeal

NKMRQQRMKMVQTADQYIFVNDAV
...|.||...|.. .|..|. ...
elvrsqrpgavpnpgqlrflyefe
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1324-1578 6.5e-27 89.0 In-house 22-277 (439) alignment 
Range on Protein: 1324-1578
Range on HMM: 22-277/439.0
FIDQFTVLEQVtqRPD-EVTHNIASQ--NNDKNRSTQFLPRDNYRVPL----KGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAI
| . |  .. .  .|| ..  ..|.|  .. |||  .  . |  || |       |  |||| .|.|| ..| .| .. |  .|. .||... ..... |
fkeifekinst..spdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

VMLCHEKEidqevCYQYWPSTPSgLVIGEYAIMLSSEEIYNGYIERKLEVKNTN--TGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGNT
|||.   |      |.||||     . |. |.    .     |. | . | |    |   ..|.|.. . |      |.   .|  .  .  .. ..   
vmltnlve.....sykywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeyg

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLT
 .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||.. ||  |.. || 
pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1349-1577 6.8e-27 89.2 In-house 8-238 (239) alignment 
Range on Protein: 1349-1577
Range on HMM: 8-238/239.0
NNDKNRSTQFLPRDNYRVPLK----GEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLVi
|. ||| .. .  |  || |.      | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| . |  . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc.

gEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKtQRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE
 .  . |   |..  || | . . .      . | ||..| |          ..| .  .. | .   |    |.|||  |||.  |    . . ..| .
.nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
  .|.|. .|. | ..|  ||| .||  |.  ||
ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1349-1577 7.5e-27 89.0 In-house 7-237 (239) alignment 
Range on Protein: 1349-1577
Range on HMM: 7-237/239.0
NNDKNRSTQFLPRDNYRVPLK----GEHPDYINAVFINGYKE-KKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLVi
|. ||| .. .  |  || |.      | ||||| ..  |    ||.| ..  .  .. .||.|. .     ||||    |  .. |.|||| . |  . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc.

gEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKtQRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE
 .  . |   |..  || | . . .      . | ||..| |          ..| .  .. | .   |    |.|||  |||.  |    . . ..| .
.nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkq

GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
  .|.|. .|. | ..|  ||| .||  |.  ||
ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_egg_pd Subfamily egg 1033-1307 8.2e-27 88.7 In-house 16-287 (307) alignment 
Range on Protein: 1033-1307
Range on HMM: 16-287/307.0
FKNQYCTLNSGDNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLnQIPgNTDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVM
.. ..  |.   .| |.| |..  |.   |   .   |  |. | ... .    .|.| | ...|     ..| .| |.  |  ||||...||. . |||
lerrlevleesvdeislttaasdnnlekarskrvhckdssrvkl.elr.rGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

VTNLKEDttIKCHQYWPEHGSTS--Y--GPFRIELTKEQVLTDYTIRKMQLTLLGSDQPPLMITQYHFtSWPDHGvpeYATSILQFHRRIKNEYKptkgP
.|  ||    .|. |||   | |  .  | .|||  | .  .|   |  .| |.|.|.  . .  .    .   .      | |.  |...|  |    |
ltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss...dvysplrvlrklrnlsk....p

MLVHCSAGVGRTGTFMAIDMGLQQAEKEgGI---DIISIINKMRQQRMKMVQTADQYIFVNDAVL---ESVTCGNTQVDSRNARI
..|..  || ...|..||.. | .  .   |    .   .  .|..|   |... .|.||   ||     |     ..|    | 
vvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdyerw
0046846 (Phosphotyrosine protein) phosphatases II 1365-1581 8.5e-27 89.4 In-house 4-174 (176) alignment 
Range on Protein: 1365-1581
Range on HMM: 4-174/176.0
RVPLKGEHPDYINAVFINGYKekkaFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLVigeyaimlsseeiyngyierkl
|..  ....||||| .| |..    .|.   |. .|  .|..|. . ..||.|.|. |.|...  |..|||   .  .                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

evkntntgstqsvmQYQITNWVSTRKMAKpQTILSVIEEMYKTQRRRgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSV
              ||. ..|.        . .|...|.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.|
..............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTVQQYQGIFQIVLTYLD
|| .||. . . .| .|.
qtpeQyrflyefellllk
0048179 (Phosphotyrosine protein) phosphatases II 1187-1286 2.3e-26 87.6 In-house 45-138 (144) alignment 
Range on Protein: 1187-1286
Range on HMM: 45-138/144.0
PPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekEGGIDIISIINKMRQQRMKMVQTADQYIFVN
.  ...||....|||||||.... .|.| . |.. ..  .||.|||||||||||||..|... .     . |... .... .|..|. .|.. .|..|. 
leregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1102-1285 3.3e-26 86.7 In-house 5-196 (199) alignment 
Range on Protein: 1102-1285
Range on HMM: 5-196/199.0
YKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWP--EHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPP-LMITQYHFTS
 .||||| |. .|. |||...|.     |||| . . .       |||  | |.. || . .      .  ||||  . ||   .  |    |..| |||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINKMRQQRMKMVQTADQYIFV
| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . ...|| |  .. . ..| |.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1102-1285 3.8e-26 86.5 In-house 4-195 (198) alignment 
Range on Protein: 1102-1285
Range on HMM: 4-195/198.0
YKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWP--EHGSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQPP-LMITQYHFTS
 .||||| |. .|| |||...|.     |||| . . .       |||  | |.. || . .      .  ||||  . ||   .  |    |..| |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINKMRQQRMKMVQTADQYIFV
| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . ...|| |  .. . ..| |.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
0049772 (Phosphotyrosine protein) phosphatases II 1348-1586 1.1e-25 86.5 In-house 45-286 (314) alignment 
Range on Protein: 1348-1586
Range on HMM: 45-286/314.0
QNNDKNRSTQFLPRDnYRVPLKG---EHPDYINAVFINGYkekKAFIIAESPMFNTARNF----------WKMI--DDRNVTAIVM--------------
 | ||||....|| |  || |.|   .  ||||| ...|.   ..||... |. .|  .|          |.|.  .|.||  |||              
lnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCHEKEIDqevcyqywpS-----TPSGLVigeyaimlsseeiyngyI-------ErklevkntntgsTQSVMQYQITNWVStRKMAKPQTILS
       |.   .           .     ..  |                                       .. ...|  ...        .. ...
aAlgKtpllildgng.........neptaadlellk.................eelydpelf............erlgikylripvpD.gsaplledfde

VIEEMYKTqrrRGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTVQQYQGIFQIVLTYLDSFETY
..| . .    . .. ..|||.. .||.. |..||  . ..   || .. ..|.  | . |     |.... .||. |....| ||. ....
flefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkf
0049260 (Phosphotyrosine protein) phosphatases II 1380-1573 1.3e-25 85.3 In-house 1-143 (152) alignment 
Range on Protein: 1380-1573
Range on HMM: 1-143/152.0
FINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWpstpsglvigeyaimlsseeiyngyierklevkntntgstqsvmQ
||.||. ...||... |. ||. .||.|. . ..|.||||. . |.. . |.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YQITNWVSTRKMAKPQTILSVIEEMYKTqRRRGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
|. ..|        .| .| ... . |  ... .  ..||||  |||.....||   .        ........  | ..||.|.. .|.. ..
ylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1344-1579 1.9e-24 80.8 In-house 32-268 (281) alignment 
Range on Protein: 1344-1579
Range on HMM: 32-268/281.0
NIASQNNDKNRSTQFLPRDNYRVPLKG-----EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTP
     || ||| ..    |  || ||      .  ||| | .|     |. .|... |  .|  .||.|| . | |||||||.  | ..| | .|.|   
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

-SGLVIGEYAIMLSSEEIYNGYIERKLEVknTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMyktqRRRgNTSIVVHCSDTVGRSAMFCAAATTI
   | . ....      . .  .  .|..  .  | |. . ..   .|   .     . .| .. ..    | |  |  |.|||  ||||  . |   ..
hcclqfdklsvsyedstvnkslvttrlnl..syegetrlithwlwkewpdwqvpessevmlkilrki....rar.stppvihcsagvgrsgtlmaveial

NKCKTEG-VIDVFQVLKSQRIQ-KPGSVQTVQQYQGIFQIVLTY
.  ..   . |. |..   |.  .  ||||.|||  |....| .
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1108-1285 6e-24 79.0 In-house 97-280 (302) alignment 
Range on Protein: 1108-1285
Range on HMM: 97-280/302.0
QGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEH--GSTSYGPFRIELTK-EQVLTDYTIRKMQ-L-----T-LLGSDQPPLMITQYHFT
  |  .||  .| || | .  ..| .....||   || .|. ..  |   .| . ..  . .. | ..| .|   |     .     .. .  .   .|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

SWPDHGVPEYATSILQFHRRIkNEYKptkGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFV
.||||| |. | . |.  .   . ||     .|||||||||||||..||  |.|   |.   |..||.  .|| |   ||...| |..
awpdhGapkeaytaldilkfc.esyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1059-1294 1.5e-23 77.9 In-house 45-277 (312) alignment 
Range on Protein: 1059-1294
Range on HMM: 45-277/312.0
PLNRFGNIVVYDDNRILLNqipGNtdcQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEH-GSTSYG
 |||. || ..|  |. |    |.   .| || | ..   ..  ....||||. .| . ||.|        |.... . ||.. || .|  .  |     
dlnrypniqcwdrgrftla...gd...enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

PFR------IELTKE-QVLTDYTIRKMQLTLLGSDQPPlMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGL
  |       |.    .     | | ... .  . |    . .| ..||||||.|.   . |..   .|..    | |.. |||||||||||.. |.  .
dhrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrllsavkkd....kkpviahcsagvgrtgtlaliesmi

QQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVT
    .    ..  .   .|..| . |..  ||...  .||| . 
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1083-1290 1.7e-23 78.2 In-house 42-256 (290) alignment 
Range on Protein: 1083-1290
Range on HMM: 42-256/290.0
TDCQNDYINACYIDgYSQDYKYIATQGPVTKT-------LVDFWRLIWQERPPVIVMVTNLKEDTTI----KCHQYWPEHGS--TSYGPFRIELTKEQVL
.  ..||| | ..  .... . |.|| | .|.       . .|| .. ||.   .||. . .| ..      | .| ||.      .. . .. ..    
krfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskeke

TDYTIRKMQLTLlgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAE-KEGGIDIISIINKM
 |  .|.. ..    |. .. .| . . .| .  |.|   ..|.  . .|..    | |..|||  |. |  .. ||..| |    ..| . . ......
ddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkal

RQQRMKMVQTADQYIFVNDAVL
|.|| .....| .. ||  ...
rkqralaitsalelafvdagiv
subfamily_CG42327_pd Subfamily CG42327 1044-1220 1.1e-22 75.1 In-house 22-192 (319) alignment 
Range on Protein: 1044-1220
Range on HMM: 22-192/319.0
DnehsvtiAVTPSNRPLNRFGNIVVYDDNRILLNQIPGntDCQNDYINACYIDGYSQ-DYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTI
|       .| .. .. .|. |.|   . |. |..|.   | .. |..| |. || . .  |||.| .  ..  ||||..|. .  ||| .|.| |    
d.......evPvtskdksrvinvvPlPetrvvlqrigd..ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGik

KCHQYWPEH----GSTSYGPFRIELTKEQVLTDYTIRKMQLTLLGSDQpPLMITQYHFtSWPDHGVPEYATSILQFHRRIKN
.| .|.| .    .  .|| ... | . .|   | |  . |  .  ..    .| | .  |.. .||   ....    ....
vcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkee.srelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1346-1581 1.4e-22 74.8 In-house 45-288 (305) alignment 
Range on Protein: 1346-1581
Range on HMM: 45-288/305.0
ASQNNDKNRSTQFLPRDNYRVPLKGEHP-DYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSG-LVI
 .|...|||  .    || || |.|  | .|| | ..    . | || ...|. .|  .|| |  . .| || |||  .|   . |..|..|     | .
eaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

GE--YAIML--SSEEIYNGYIERKLEVKNTN---TGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGntSIVVHCSDTVGRSAMFCAAATT
 |    |..   | . ..   . | .|..|     |. ... . .   |.       | . |...| . |..  .|   ||||||  .||.         
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg..pivvhcsagigrtgsvvmleyi

INKCKTEGVID-VFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYLD
...  .  .|.   ..|.  | |.  |.|| .||  . |..| |. 
ldqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1059-1153 1.5e-22 74.8 In-house 49-155 (350) alignment 
Range on Protein: 1059-1153
Range on HMM: 49-155/350.0
PLNRFGNIVVYDDNRILLNQIPGN------TDCQNDYINACYIDGY------SQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQ
  ||. ||. |. .|. |.. . .      .   |||||| |.           |.||||||.|. .|. ||...| .   .||...|.. |    ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPEHGS
||.| . 
YWqegsy
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1338-1580 2.4e-22 74.2 In-house 24-270 (285) alignment 
Range on Protein: 1338-1580
Range on HMM: 24-270/285.0
PDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEHPDYINAVFIN-GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPS
| ..|.     | | || ..    .. || ||    ||| | ..    |.. ..| .. |. .|  .||.|| . ... ..|||   |   | |  |.| 
ppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

TPSGLV-IGEYAIMLS--SEEIYNGYIERKLEVKNTNTGSTQSV-MQYQITNWVSTrKMAkPQTILSVIeEMYKTQRR--RGNTSIVVHCSDTVGRSAMF
    .| .|.| | |.   ||   | |   | | ||.  |.. . |..    |    ..| |.    .| |.||  ..    .. |.||||  |||.| |
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpd.qla.pedarpmi.elykwvkkvnpkekpicvhcsagvgrtatf

CAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
     .  .   .  |.......  |  .  .||.  |.  .. ... |.
vgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0051082 (Phosphotyrosine protein) phosphatases II 1372-1574 5.9e-22 73.3 In-house 2-147 (151) alignment 
Range on Protein: 1372-1574
Range on HMM: 2-147/151.0
HPDYINAVFINGYkekkaFIIAESPmfntARNFWKMIDDRNVTAIVMLCHEKEIDqeVCYQYWPSTPsglvigeyaimlsseeiyngyierklevkntnt
..||||. .. |.     ...   |       |.... . ....||.|. |.|..   |..|.|..                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

gstQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKtqrrRGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVQQYQG
     |....|..|  .     ....|...|.. .     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||. ||.. 
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

IFQ
...
qlf
subfamily_ptpA1_pd Subfamily ptpA1 1327-1539 9.5e-22 72.3 In-house 26-255 (418) alignment 
Range on Protein: 1327-1539
Range on HMM: 26-255/418.0
QFTVLEQVTqRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKG----EHPDYINAVFINGYKEkKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHE
.| .||.    | | .     .|  ||| |. || .  || ||     |  ||||| .|.|    | || .. |. ||  .||.|. .  .  |||| .|
efrlleesv.gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsre

KEIDQEVCYQYWPSTPSGLvigEYAIMLSSEEIYNGY----------IERKL---EVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQR
 |  .  | .|||    |    ...|    .|..  |           ||..   ... |  | |. . |||   |       . | .  ..  . . | 
sencrikcdrywpeqigge...qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

R-----RGNTSIVVHCSDTVGRSAMFCAAATTINK
.       |  |.||||  |||.  ||.|   ..|
qiipssdrnvpiivhcsagvgrtgtfctavimmkk
PTPc_DSPc_SM00012 1477-1576 1.4e-21 72.0 In-house 2-103 (105) alignment 
Range on Protein: 1477-1576
Range on HMM: 2-103/105.0
VMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
|..|..|.|  . .  ... ||...... | .. .. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| .||. . .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IV
..
al
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1057-1286 1.8e-20 67.6 In-house 51-278 (302) alignment 
Range on Protein: 1057-1286
Range on HMM: 51-278/302.0
NRPLNRFGNIVVYDDNRILLNQipgntdCQNDYINACYIDGYSQDYKYIATQGPVTKTL---VDFWRLIWQERPPVIVMVTNlKEDTTIKCHQYWP-EHG
|   |.  .. ..|.|.. |..      ....|.||  ..  .  .. | .| |....     .|||...||.   .|..   .|. .   ....| . |
nlkknqsedvpildsnlvklea......epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvg.eeelkktlselfpkksg

-STSYGPFRIELTKEQVLTDYTiRKMQLTLLGSDQP-PLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGL
  . || ...   | .   . .  .  . .|  .    .... |..| |... ||.  ... .    . ..  ... ....    |.|| |.|..  . .
dykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

QQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVN
.. .|.    |  |....|.|| ..|....||... 
eklqkgkepnikeivksiRsqRpravdslkQyvsly
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1114-1293 2.2e-20 67.8 In-house 40-221 (255) alignment 
Range on Protein: 1114-1293
Range on HMM: 40-221/255.0
TLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTL-LGSDQPPLMITQYHFTSWPDHGVPEYATSIL
|.  |.. | | .. |.||.....|..  ||..|.|           ...|  .  .|  .| ...|. ||  .    .. |... |...  || |  ||
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

QFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESV
.  . ...  |    ...||||.|.||. .|. ...  |      .  . ...| .|.....|..| . ..|  |  |    ||. |
nilkvvrds.k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0044763 (Phosphotyrosine protein) phosphatases II 1370-1576 3.4e-20 67.9 In-house 15-167 (178) alignment 
Range on Protein: 1370-1576
Range on HMM: 15-167/178.0
GEHPDYINAVFINGYkekkaFIIAESPMfntaRNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSglvigeyaimlsseeiyngyierklevknt
 |  |||||..| ..     ....  |.     ...... . ..|.||.|..|.|  .. |..|||.  .                              
lersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..............................

ntgstqsvMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRrRGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVQQY
        .||. ....       .. .| ..| . . .  . .  ..||||  ||||....||   .      |. .......  | ..|  |..  |.
........iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgql

QGIFQIV
. . .. 
rqLyefe
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1346-1580 4e-20 66.7 In-house 52-289 (305) alignment 
Range on Protein: 1346-1580
Range on HMM: 52-289/305.0
ASQNNDKNRSTQFLPRDNYRVPLKGEHP-DYINAVFING-YKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLVI
|  .  ||| ..   .|.  | |.   | ||| | ..      .| || |. |. .|  .|| |. ...|  |||||.  |. .  | |||| .    . 
adiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

GEYAIMLsSEEIYNGYIERKLEVKNTNT------GSTQSVMQYQITNWvstRKMAKPQTILSVIEEMYKTqrRRGNTSIVVHCSDTVGRSAMFCAAATTI
    |..  .   .  .||  |.. |        . . || . | |.|        |   |. .| .     |  .  ||||||  .||.    |    .
lksgivv.envsgskpmerdaeiqitllnltysgdqkmsvrhlqwtew...pdrgvppckltslellsai..rgskvpivvhcsagigrtgtivaieyil

NKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.|   .  .  . ...|. | |.  |.|.  ||  | ...| |.
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1348-1580 7.2e-20 66.2 In-house 42-271 (288) alignment 
Range on Protein: 1348-1580
Range on HMM: 42-271/288.0
QNNDKNRSTQFLPRDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPS-GLVIGEY
.|  ..| ..    |  || |. .   ||.|  .   | |. .| |..|.  |  ..|||. . .|  |||||.  |  .|   .|.||       || .
anptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

AIMLSSEEiynGYIERKLE---VKNTNTGSTQSVM-QYQITNWVSTRKMAKPQTILSVIEEMyktqrRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
  .   .      |.. ..   ......| .. .. .  . .|       . .. | ..| .     .  .  ||||.|  |||.. .      ..  . 
ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrl

EGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
.  . . ..|.. | ..  ..|| .||  ....|| .|
ddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1318-1579 7.5e-20 65.7 In-house 23-289 (310) alignment 
Range on Protein: 1318-1579
Range on HMM: 23-289/310.0
KTGRTGFIDQFTVLEqvTQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLK---GEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVT
| |  |.. |.  |.  ...   .|..   ..  ||| .. . .|. || ||     . ||| | ...    ...|| .. |.  |  .||.|| .    
klgieglvkqyrkld..akqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqerae

AIVMLCHEKEIDQEVCYQYWPSTPSGLVIGEY---AIMLSSEEIYNGYIERKLEVKN---TNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQ
.|..||.  |  .  |  ||||       |      .  ||||.    .   .   |    .  .    .. .. .|     .  |.     . .   .|
silllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaq

RRRGNtsIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
 | |    |||||  ..|  . .|   .|.| .    .|. .|    . ..   .||  ||  | .. . .
vrhgp..cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_egg_pd Subfamily egg 1327-1580 1.4e-19 64.9 In-house 19-270 (307) alignment 
Range on Protein: 1327-1580
Range on HMM: 19-270/307.0
QFTVLEQVTQRpDEVTHNIASQNNDKNRSTQFLPRDNYRVPLK---GEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHE
.. |||.....   .|. ... | .| || .   .|  || |.   | .  |.| |  ..|      ||.|..|. ||  .||.|.   .|  ||||   
rlevleesvde.islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsr

KEIdqEVCYQYWPSTPSG-LVI--GEYAIMLSSEEIYN--GYIERKLEVKNTNtgSTQSVMQYQITNWVSTRKMAKPQTILSVIeemyktqrRRGNTSIV
||   | |  ||| ..|  ||.  | . |     .      .   || .  ..    .  ...   ..  . ..  |  .|  .        |.  . .|
kes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdvnnssdvysplrvlrkl........rnlskpvv

VHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVQQYQGIFQIVLTYL
|.. . | ..| . |. ... .    | |  . ||..    | ... ||..| .|  ....|| ..
vqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_CG42327_pd Subfamily CG42327 1323-1507 5.1e-19 63.1 In-house 6-193 (319) alignment 
Range on Protein: 1323-1507
Range on HMM: 6-193/319.0
GFIDQFTVLEQVTQRPDevthNIASQNNDKNRSTQFLPRDNYRVPL--KGEHP--DYINAVFINGYKEKKA-FIIAESPMFNTARNFWKMIDDRNVTAIV
  ...|  | |.  | |    ..    .||.|  . .|  . || |  .|...   |..| .. ||.. .. .| |. .. ... .||... ...   ||
dvaeefrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrviv

MLCHEKEIDQEVCYQYWPST---PSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQItNWVSTRKMAKPQTILSVIEEMYKT
 |.   |   .|| .|.|.    ..  . |.. . |   |. . |.   | .|. .   .. .  |   .|. .   |......... |. ..
qltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1179-1290 2.6e-18 60.9 In-house 207-341 (350) alignment 
Range on Protein: 1179-1290
Range on HMM: 207-341/350.0
LTLLGSDqpPLMITQYHFTSWPDHGVPEYATSILQFHR--------RI-KNEYKPT-KGPMLVHCSAGVGRTGTFMAIDMGLQQ------A-EK------
.||  ||  |... | ..  |.| ..     ||||            . .. ..     |.|||||||||||||....|. |..        ..      
itlaasd..PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldv

-EGGIDII-SIINKMRQQRMKMVQTADQYIFVNDAVL
     |.|  |.|..|.||..|||. ||.||. .|.|
aaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1348-1580 4.6e-18 59.7 In-house 50-285 (302) alignment 
Range on Protein: 1348-1580
Range on HMM: 50-285/302.0
QNNDKNRSTQFLPRDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTA---RNFWKMIDDRNVTAIVMLCHEKEIDQeVCYQYWPSTPS-GLVI
.| .||.|...   |. .| |..|  .|.||  ..  . ..  |.|  |  ...    .||.|. ..... .|.|  |.|...    ...| .    .  
knlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykey

GEYAIMLSSEEIYNGYI-ERKLEVKNtnTGSTQSVM--QYQITNWVSTRKMAKPQTILSVIEEMYKtQRRRGNTSIVVHCSDTVGRSAMFCAAATTINKC
|.  .     |  ..   .  .||     | ..||.   | .||| ...   |  ..   ...... .   .. ..|.     .|| ..| ..|....| 
gkmfvNnrkVekaeeektryviEvlP..egcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfa.kkikadentvivSknGaGRagafltlavavekl

KTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
...    . ...|| | |.| .|....||  .. ..|.|.
qkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_hpo-7_pd Subfamily hpo-7 1112-1296 6.6e-18 59.6 In-house 44-230 (263) alignment 
Range on Protein: 1112-1296
Range on HMM: 44-230/263.0
TKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGSTSYGPFRIELTKEQVLTDYTIRKMQLTL-LGSDQPPLMITQYHFTSWPDHGVPEYATS
 .|.  |.. | | .. |.||... .|.   || .|.|           ....  .|  |  ..  .|.  ||  .    ...| .. |...  || | .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

ILQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCG
||.  .  .|  |    .. ||||.|.||.  |  ...  |      .  . ...| .|.....|..| . ..|  |  |    ||. |   
ilnilkvarns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1365-1577 8.4e-17 56.2 In-house 34-256 (290) alignment 
Range on Protein: 1365-1577
Range on HMM: 34-256/290.0
RVPLKGE----HPDYINAVFINgYKEKKAFIIAESPMFNT-------ARNFWKMIDDRNVTAIVMLCHEKEIDQE----VCYQYWPSTPS-GLVIGEYAI
||.|||       ||| | ..  . .  ..|. .||  ..         .|| |. . .|. .||||  .| ...     | .| | .    | ..   .
rvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltv

MLSSEEIYNGYIERKLEVKNTNtGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTqrrrgNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVID
   | |  .. ..|.|.||  . .    |  ... .| ..    ...|.||.|. . .      .| ..||| | . |||.. |      |   |.| . 
kCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvk

VFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
. .|||. | |.   ... ...  .   ..
ledvlkalrkqralaitsalelafvdagiv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1385-1575 1.3e-16 55.3 In-house 2-199 (199) alignment 
Range on Protein: 1385-1575
Range on HMM: 2-199/199.0
KEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGlvIGEYAIMLSSE---EIYNGYIERKLEVKN--TNTGSTQSVMQ
| .. .| .. |. .|  .||.|. .     |||.  ..   .     |||.| ||   |.|. .  .         |    | . |  |   ||. . .
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesg..tgkygslsvttktittkpdytitaliltnnttappstreish

YQITNWV--STRKMAKPQTILSVIEEMYKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
||.| |   .| ..|    ..    |. |   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.|
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq

I
.
v
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1386-1575 1.7e-16 55.0 In-house 2-198 (198) alignment 
Range on Protein: 1386-1575
Range on HMM: 2-198/198.0
EKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGlvIGEYAIMLSSE---EIYNGYIERKLEVKN--TNTGSTQSVMQY
 .. .| .. |. .|  .||.|. .     |||.  ..   .     |||.| ||   |.|. .  .         |    | . |  |   ||. . .|
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesg..tgkygslsvttktittkpdytitaliltnnttappstreishy

QITNWV--STRKMAKPQTILSVIEEMYKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQI
|.| |   .| ..|    ..    |. |   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . ..|.|. |.|.
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_CG42327_pd Subfamily CG42327 1223-1287 4e-16 53.6 In-house 244-309 (319) alignment 
Range on Protein: 1223-1287
Range on HMM: 244-309/319.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINKMRQQRMKMVQTADQYIFVND
.  .||. |||| ||||||. .| |. ... |.    .||  ..  .|..| . |.| .|| |.  
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1348-1440 2.1e-15 51.4 In-house 30-128 (297) alignment 
Range on Protein: 1348-1440
Range on HMM: 30-128/297.0
QN--NDKNRSTQFLPRDNYRVPLKGEHP--DYINAVFINGYKEKK--AFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSG
.|    ||| .. |  |. || |..  .  ||||| ..   .|..   .|.|. |. .|  .||... ...| .|||... .|  .. |. ||||.  .
rnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1332-1488 2.5e-15 50.8 In-house 77-233 (244) alignment 
Range on Protein: 1332-1488
Range on HMM: 77-233/244.0
EQVTQRPDE--VTHNIASQNNDKNRSTQFLPRDNYRVPLK-GEH-PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQ
 |   |||   .   .  .|. |||    || |  ||||  |     |||| |.        .|... |. .|. .||||. .| |  .|.|   .| |.
sqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede

evcyqYWP-STPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVST
     ||| | |      . .. |.  . .      .||..     | |..  .||.|| | 
.....ywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsd
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1350-1586 4.5e-15 50.1 In-house 44-282 (312) alignment 
Range on Protein: 1350-1586
Range on HMM: 44-282/312.0
NDKNRSTQFLPRDNYRVPLKGEHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTpSGLVI-GEYAI
.| ||  .    |  |  | |.   || | |..     . |.....|. ||. .||..      |.|..||   |   | | .|      |.|   .. .
kdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi.vgfvdledhrv

ML-SSEEIYNG------YIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRrrgntSIVVHCSDTVGRSAMFCAAA---TTIN
   .  ||  |         | | |    ||    . .|| . |         .| | ..  . | ..      .. |||  |||.  ..      ... 
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalr

KCKTEGVIDVFQVLKSQRIQkpgSVQTVQQYQGIFQIVLTYLDSFETY
. . . | |.| .|. .| .   ||... ||   ...|| .| |   |
hprkqnvkdsfvllrkdrar...svrvfpqyvyalrcvleflyskgly
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1342-1580 1.6e-14 48.6 In-house 22-221 (255) alignment 
Range on Protein: 1342-1580
Range on HMM: 22-221/255.0
THNIASQNNDKNRSTQFLprdnyrvplkgehpdyinavfingykekkafiiaespmfnTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGL
|.... ... |..... |                                        |  .|...|   . . .||||  .| ..| | .|.|    . 
tehvkPekdkkrknlysl........................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdek

VIGEYAIMLSSEeIYNGYIERKLEVKNTNT--GSTQSVMQYQITNWVSTRKMAKPQTILSVIeemyKTQRRRgnTSIVVHCSDTVGRSAMFCAAATTIN-
 . .   . ...   .  . | ||.  | .    |. |  |. . |.       .. || ..    |  |     |.|||||  .|||| |  |      
lkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqk

------KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
      . .| . .|  ..|.  | .......|  |    . .||...
mirsldttet.veldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1229-1296 2e-14 47.7 In-house 1-68 (69) alignment 
Range on Protein: 1229-1296
Range on HMM: 1-68/69.0
MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCG
|.||||.| ||||||.|| . . .   |  .||   .. ||. |  ||    .|||. ||. |..  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
0048076 (Phosphotyrosine protein) phosphatases II 1433-1577 3.7e-14 48.1 In-house 2-140 (145) alignment 
Range on Protein: 1433-1577
Range on HMM: 2-140/145.0
YWPST-PSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRrgNTSIVVHCSDTVGRSAMFC
||||    || .| .   |. |.. .  | . | . .. .. .. ..||. ..|        ....|...| . . ...  .  ..||||  |||.....
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlv

AAATTINkcktEGvIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVL
||   .     .| ......|.  | | ||.|....|.. ... .|
aaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_hpo-7_pd Subfamily hpo-7 1392-1579 5.8e-14 46.6 In-house 42-226 (263) alignment 
Range on Protein: 1392-1579
Range on HMM: 42-226/263.0
IaespMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLVIGEyAIMLSSEEIYNGYIERKLEVKNT--NTGSTQSVMQYQITNWVSTR
.    . .|  .|...|   . . .||||  .| ..| | .|.|    .  . .  . ... .. .  . . ||. .|  .   |. | .|. . |. ..
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla.nvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekn

KMAKPQTILSVIEEMyktqrrRGNTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
   ... || ...        |.  |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......|  |    . .||..
dpelareilnilkva......rnskslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1231-1296 8.2e-14 45.7 In-house 2-67 (69) alignment 
Range on Protein: 1231-1296
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCG
||||.| ||||||.|| . . .   |  .||   .. ||. |  ||   ..|.|. ||. |..  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
fn3 Fibronectin type III domain 469-551 1.2e-13 44.1 Pfam-A 2-82 (85) alignment 
Range on Protein: 469-551
Range on HMM: 2-82/85.0
PVGDVIFSSVESVSMTVSWDEVPcnGRNGPITGYYLTYTNITSNT-SYTVNITGGDNrMYNLNGLIPYTNYTVSIVPYNYNMTG
..... .|.| | |.|.||.. .   ..|||||| ..| . ...  . ......  .  ..|.|| |.|.|....  .| . .|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngageg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1223-1293 1.4e-13 45.3 In-house 225-295 (297) alignment 
Range on Protein: 1223-1293
Range on HMM: 225-295/297.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESV
.| . ..||||||||||.|  .  |. |..  |.   |. .|....|.|| ..||| .|. .. ||||. .
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
fn3 Fibronectin type III domain 576-646 2.6e-13 43.1 Pfam-A 12-84 (85) alignment 
Range on Protein: 576-646
Range on HMM: 12-84/85.0
TLTEIIIAWNPPTIPNGIITVYEIRYRESTSTG-PYSITNTTNT-YYSILGLIPNTSYTIGVRAYTSIGPGEW
| |.. . |.||. ..| || ||..|||..... . ..|.. .|  . . || |.|.|.. |.|..  | |..
tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1085-1161 2.6e-13 44.0 In-house 88-163 (349) alignment 
Range on Protein: 1085-1161
Range on HMM: 88-163/349.0
CQNDYINACYID--GYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEhgsTSYGPFRI
  .||||| |.    .| . |||||| |.  |. ||...|  .. .... ... || .  ||..|| |    ||  ...
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe...lsysnitv
I-set Immunoglobulin I-set domain 905-991 4.2e-13 40.9 Pfam-A 1-90 (90) alignment 
Range on Protein: 905-991
Range on HMM: 1-90/90.0
PVIEEFPSNKTTEEGCQVLFKVKVKETLKLSFNWYHNGEPVTDDYAHELRGDG---SLLLVSVEEKHKGTYRFVANNDAGTVSQQVVLTV
|.... ... ...|| .| ....|... ..|..|...|.... .  .... ..   .| . .||.. .|.|. .|.| ||...... |.|
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1013-1109 5.4e-13 43.0 In-house 5-95 (95) alignment 
Range on Protein: 1013-1109
Range on HMM: 5-95/95.0
IPVGQFGEFVANGHAKGNEGFKNQYCTLNSGdNEHSVTIAVTPSNRPLNRFGNIVVYDDNRILLNqipgnTDCQNDYINACYIDGYSQDYKYIATQG
| |  |   | . |.. .. | |.. ...      . |.  . .| | ||| ||. ||  |. |      |  . ||||||..|||..   |||.||
ihvsvfhshvlemhsnsdqefdnefksismt.sgapytvgsseanipknrflnifpydatrvvlt.....tkrdsdyinacfvdgyarkncyiaaqg
0048179 (Phosphotyrosine protein) phosphatases II 1406-1573 7.9e-13 43.8 In-house 23-138 (144) alignment 
Range on Protein: 1406-1573
Range on HMM: 23-138/144.0
KMIDDRNVTAIVMLCHEKEIDQEVCYqywpstpsglvigeyaimlsseeiyngyierklevkntntgstqsVMQYQITNWVSTRKMAKPQTILSVIEEMY
... . ..|... |..| | . . ..                                             ..||. ..|        .. .|...| . 
ellkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefie

KTQRrrGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVQQYQGIF
. ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|.. .|.. . 
eale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1187-1291 1.8e-12 41.2 In-house 216-342 (349) alignment 
Range on Protein: 1187-1291
Range on HMM: 216-342/349.0
PPLMITQYHFTSWPDHGVPEYATSILQFHRrIKNE----------YK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQ---QAEKE--------GGIDIIS-
 | .. |  .  |.| ..     ||||    .||.          ..     ..||||||| ||||... .|. |.     ..|           |.|| 
kPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisi

IINKMRQQRMKMVQTADQYIFVNDAVLE
|.|..|.||. |||   |.|.. .|.|.
ivnelrkqrismvqnlaqfiaiyealLk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1393-1573 2e-12 41.2 In-house 96-281 (302) alignment 
Range on Protein: 1393-1573
Range on HMM: 96-281/302.0
AESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSG-LVIGEYAIML-SSEEIYNGYIERK------LEVKNTNTGS--TQSVMQYQI
   |  .|   .| .|.. ||. .| ||. .| ... | .|.     | |  |.|..   | ..  . . ..|      .|.||... .   ..|   . 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TNWVSTRKMAKPQTILSVIE--EMYKtqrrrgnTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIF
. |      ....| | ..   | ||       ....||||  |||.  . |    |. |... | |. ....  |  . |.||. ||   ..
sawpdhGapkeaytaldilkfcesyk.......knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1056-1293 3.5e-12 40.5 In-house 46-279 (303) alignment 
Range on Protein: 1056-1293
Range on HMM: 46-279/303.0
SNRPLNRFGNIVVYDDNRILLnqipgnTDcqNDYINACYIDGYSQDyKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQYWPEHGST-
.|   ||| .... |  .. |      .|    || | |..  |.  | | || |...|  |||..| ...  .....    |  ..  .  .|.     
knmdknrfvdvicldhskvkl......sd..ssyihasyleldssk.kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

SYG--PFRIELTKEQVLTDYTIRKMQLTLLGSDQPplMITQYHFTSWPDHGVPE-----YATSILQFHRRIKnEYKPTKGPMLVHCsAGVGRTGTFMAID
 .     |.   |.  |.|    |.     |. .   ..  .|. .||   .|      .   | |    ..  | ... .. .   .|.||.|||  ..
kfeersirvgefkrvelgdgwvlkvlsvsngdyks..flhvhhykawphnsipsdgspkfvkqiwqlqsvlr.kysdstptvymsl.sgcgragtfalfe

MG-LQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESV
   |   ...  .|..  ....|. |.. ||   |. .|   . | |
tahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1475-1580 4.4e-12 40.0 In-house 89-194 (440) alignment 
Range on Protein: 1475-1580
Range on HMM: 89-194/440.0
QSVMQYQITNWVSTRKMAKPQTILSVIEEMYKTQRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQ
... ||.   |           .| .|... ..| . ||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| .||  ...
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhe

IVLTYL
 ||  |
avlegl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1334-1576 1.1e-11 38.9 In-house 31-275 (303) alignment 
Range on Protein: 1334-1576
Range on HMM: 31-275/303.0
V-TQRPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKgeHPDYINAVFINGYKEKKAfIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQ
| .  | .|..|   .| |||| .. .  |  .| |      || | ...   .||| |... |.  || .||.|| ...|  ...|  . | |.     
vvsylppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggds

YWPSTPSGLVIGEYAIMLS---SEEIYNGYIERKLEVKNTNTGSTQSVMQYQITNWVSTRKMAKPQTIlSVIEEMYKTQRRRGNTSIVVHCS-DTVGRSA
 .|     | . | .| .      |. .|.  . | | | .  |   | .|.     |    . |. .   | ..    |.  ...  |. |   .||. 
vfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfv.kqiwqlqsvlrkysdstptvymslsgcgrag

MFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIV
 |.   |.    .  .  .|. ..|.  |  .  .|| . |.  .. ..
tfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1348-1436 4.1e-11 37.2 In-house 46-152 (350) alignment 
Range on Protein: 1348-1436
Range on HMM: 46-152/350.0
QNNDKNRSTQFLPRDNYRVPLK------------GEHPDYINAVFINGY----KEKKAF--IIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEV
.   ||| .. || .  || ||             .  ||||| ...      . .  |  | . .|. .|  .|.|.|   .|. |..|  . | . | 
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CYQYWPS
||.||. 
cyrYWqe
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1096-1166 6.5e-11 36.2 In-house 230-298 (440) alignment 
Range on Protein: 1096-1166
Range on HMM: 230-298/440.0
DGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTtikCHQYWPE-HGSTSYGPFRIELTKE
.|||.   .|||| |.  |..|||||. . |   |.|. .|.. |   |  |||    | ..||| .     
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgs
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1372-1488 2e-10 35.1 In-house 12-124 (130) alignment 
Range on Protein: 1372-1488
Range on HMM: 12-124/130.0
HPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQevcyqYWPST-PSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTN
  .|||| |.      . .. .. |. .|. .||||. .| |  .|.|   .| |.     ||| . |      .  . |.  . ..     .||...  
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikasnleiesdl

TGSTQSVMQYQITNWVST
  | |..  .||.|| | 
neshqaltmfqisnwpsd
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1050-1151 3.9e-10 33.8 In-house 89-181 (244) alignment 
Range on Protein: 1050-1151
Range on HMM: 89-181/244.0
TIAVTPSNRPLNRFGNIVVYDDNRILLNQipgnTDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDttikcHQYWP
  |. |.|   || |  . .| ||. |..        | |||| ..    .  .|| || |.. | .|||... .    |.|..  ..|.      .|||
kdafnpnnswknregaglpfdfnrvplsk....gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp

EH
. 
ds
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1381-1485 3.9e-10 33.6 In-house 229-328 (440) alignment 
Range on Protein: 1381-1485
Range on HMM: 229-328/440.0
INGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLcheKEIDQEVCYQYWPSTPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNTNtgSTQSVMQY
..||  |.||| .. |.  |  .||... | ....|.||   .....  |  |||     . .| ...     |  |    | ||.|  .    . . |.
fegyskknafiatqmpldstvldfwrlvhdyristiiml...nqlndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyke..evheirqf

QITNW
..  |
evqtw
subfamily_eak_pd Subfamily eak 1049-1217 5.7e-10 33.1 In-house 42-206 (332) alignment 
Range on Protein: 1049-1217
Range on HMM: 42-206/332.0
VTIAVTPSNRPLNR-FGNIVVYDDNRILLNQIPGNtdcQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIKCHQY
 .| .|     .||   .|| || . . |     |   .. ||||  ..      ||| |  .  . .  ||... ... | ||.. .  |    |  .|
lsisetarleavnrnvvkivpydrylvrltssqln...rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdky

WPEHG--STSYGPFRIELtKEQVLTD-YTIRKMQLTllgSDQPPLMITQYHFTSWPDHGVPEYAtSILQFHRR
.|...    ..| . .|  || |  . .  |...|.          .  |..  | .  .| |    | ... 
fpdktreelkfGildver.kefvkrniletrllels...kGnethrvlhykvfGwtettlpkye.dflalrkv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1505-1579 1e-09 32.7 In-house 221-294 (297) alignment 
Range on Protein: 1505-1579
Range on HMM: 221-294/297.0
YKTQRRRgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
....  | |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||..|.. ....||  
lraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1390-1580 5.8e-09 29.0 In-house 117-309 (346) alignment 
Range on Protein: 1390-1580
Range on HMM: 117-309/346.0
FIIAESPMFNT---ARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTPSGLVIGEYAIMLSSEEIYNGYIERKLEVKNtnTGSTQSVMqYQI---T
.|.|. | ..      .|| || . ..  . ..  .  . .     .          |   |     ..     |  .||     | ..||.  |.   .
livaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlp..egnsdsvi.cqvhhha

NWVSTRKMAKPQTILSVIEEMYkTQRRRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTYL
 |   ..  |   |. .| ... ....  |. . |      ||.  |  |  .||.       ......|. . |.||.|..  || .|. ||. |.
pwkhlqqppktlpiikmihqfl.sekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1057-1139 1e-08 29.0 In-house 34-113 (332) alignment 
Range on Protein: 1057-1139
Range on HMM: 34-113/332.0
NRPLNRFGNIVVYDDNRILLNqiPgnTDCQNDYINACYIDGYSQDYKYIATQGPVT-KTLVDFWRLIWQERPPVIVMVTNLKED
|  .||   . ..| .|. |   |   | ..|. || ..||||.   || .| |.  .|   |||.. . .| .|... .. | 
nmdmnriphlycfdhsrvela..p..qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1013-1098 1.2e-08 28.8 In-house 6-86 (440) alignment 
Range on Protein: 1013-1098
Range on HMM: 6-86/440.0
IPVGQFGEFVANGhaKGNEGFKNQYCTLNSGDNEHSvTIAVTPSNRPLNRFGNIVVYDDNRILLNQIPGNTDcqNDYINACYIDGY
| | .| ..| |   .    |..... | ||  . |  ||  |.|.  ||. ||..|| .|..|... |  |  .||||| ||.| 
iivadfadyvqnn..rrsrafedewsllpsglsqps.diaslpnnkvknryrnilaydhsrvmleevkgvpd..sdyinasyingi
subfamily_eak_pd Subfamily eak 1351-1504 1.9e-08 28.1 In-house 54-207 (332) alignment 
Range on Protein: 1351-1504
Range on HMM: 54-207/332.0
DKNrSTQFLPRDNYRVPLKG---EHPDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPSTP-SGLVIGEY
..|   . .|.| | | |     ..  ||||  ..  .  . .|..  .  .    ||.|. ...  |||.| .. | . |   .|.|      |  | .
nrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

AIMLSSEeIYNGYI-ERKLEVKNTNtgSTQSVMQYQITNWVSTRkMAKPQTILSVIEEM
 .   .  . .. .  |.||..  |   |  |. |..  |  |  . | .  |.. . |
dverkef.vkrniletrllelskGn..ethrvlhykvfGwtett.lpkyedflalrkvm
subfamily_CG42327_pd Subfamily CG42327 1510-1579 4.3e-08 27.2 In-house 244-314 (319) alignment 
Range on Protein: 1510-1579
Range on HMM: 244-314/319.0
RRGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVQQYQGIFQIVLTY
|  .  .|||||| |||. .  |.  .|.. ..    .|. |.. | | ..  .|.|..||. |....  |
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
0038934 (Phosphotyrosine protein) phosphatases II 1193-1278 1.1e-07 27.2 In-house 81-162 (194) alignment 
Range on Protein: 1193-1278
Range on HMM: 81-162/194.0
QYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQqaekeGGIDIISIINKMRQQRMKMVQT
.|.   .||.|..     .|.| . ..  ..  ..|  .||| ||.|||||. |  .         |..    |. .|. | .....
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipn
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1337-1421 1.4e-07 25.4 In-house 25-118 (347) alignment 
Range on Protein: 1337-1421
Range on HMM: 25-118/347.0
RPDEVTHNIASQNNDKNRSTQFLPRDNYRVPLKGEH---------PDYINAVFINGYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCH
 | ..| .   .. .|||| .    |. || |  |.           ||||  |.  . .| .|... |. .| |.||||.   .|| .| .  
spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_PTPDC1_pd Subfamily PTPDC1 1194-1287 3.1e-07 25.0 In-house 85-170 (182) alignment 
Range on Protein: 1194-1287
Range on HMM: 85-170/182.0
YHFTSWPDHGVPEYaTSILQFHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAekeggIDIISIINKMRQQRMKMVQTADQYIFVND
..  .|.|.||.   ..||.  . ..   .  .| . ||| || ||||  .|  .  ..      ..    |...|..| | .|| .|  .|..
vynfgwkDygvasl.eriLdivkvvafalq..egkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1061-1143 3.2e-07 24.2 In-house 41-126 (347) alignment 
Range on Protein: 1061-1143
Range on HMM: 41-126/347.0
NRFGNIVVYDDNRILLN---QIPGNTDCQNDYINACYIDGYSQDYKYIATQGPVTKTLVDFWRLIWQERPPVIVMVTNLKEDTTIK
||  .  . |. |..|       ...|  . |||| .|     . .|| || |. .|. |||...   .   .| . . ..| .|.
nrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaie
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1348-1420 6.6e-07 23.1 In-house 33-108 (332) alignment 
Range on Protein: 1348-1420
Range on HMM: 33-108/332.0
QNNDKNRSTQFLPRDNYRVPLKGE--HPDYINAVFINGYKEKKAFIIAESPMFN-TARNFWKMIDDRNVTAIVMLC
.| | ||  ..   |  || |  .  . |. || ...|| .| |.|.|..|. . |   ||.|. .|. . |... 
nnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfg
TMEM154 TMEM154 protein family 776-855 7.2e-07 20.6 Pfam-A 22-90 (146) alignment 
Range on Protein: 776-855
Range on HMM: 22-90/146.0
ViqastliqtSTVMQASTSHTSGTPVTTSAPSSNPTESSAGGSSTsaiAAGIIVPLLLL-IIIVIVIIVVVVSKKKKGKHE
|         ..   ||..... ......  . . .| ||    .      ||.|...| .....|.|.|.. |.|. |.|
v.........tastlasvtdpetlsanvnleegelseksadqael...vlmiiiPsvvLillllvvvilvikkkrkrrKqe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1369-1436 9.9e-07 22.4 In-house 86-155 (349) alignment 
Range on Protein: 1369-1436
Range on HMM: 86-155/349.0
KGEHPDYINAVFIN--GYKEKKAFIIAESPMFNTARNFWKMIDDRNVTAIVMLCHEKEIDQEVCYQYWPS
 |   ||||| ...   .. .| .|    |.  |  .|.|.|   .|  .. | ..|| . | |..||  
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1102-1292 2e-06 20.7 In-house 115-308 (346) alignment 
Range on Protein: 1102-1292
Range on HMM: 115-308/346.0
YKYIATQGPVTK---TLVDFWRLIWQERPP-VIVMVTNLKEDTTIKChQYWPEHGSTSY-GPFRIELTKEQVLTDYTIRKMQltLLGSDQPPLMITQ-YH
.| | .| |  .    . ||| .|.||.   | .|| . |   |     .  | |   | | . |.  . .|  |     ..  .|   .   .| | .|
hklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklknttts.lfndenggyqytgkmfinnrradvsgdpkeytie..vlpegnsdsvicqvhh

FTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLES
 . |     |  .  |...  ... | .  .  . |    | ||. .|.     ..| .     .|. |. ...|||   |..  ||  .   |.. 
hapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdy
DUF3827 Domain of unknown function (DUF3827) 820-915 2.7e-06 14.3 Pfam-A 268-367 (684) alignment 
Range on Protein: 820-915
Range on HMM: 268-367/684.0
TSAIAAGIIVPLLLLIIIVIVIIVVVVSKKKKG-K-HEVVYYNTRAKP--AALEAVSYSVDHVGQYEEVKLETRCGPPPPPAPFKTATPPVIEEFPSNKT
   | .|..||.|. ..|.|..  ..  |.|.  |   |   . |.|.   . .   .   |.|| ..  .     | | |.. |.|.|    | |..| 
nlWiivgvvvPvlvvvviiiilyakLCRkdkldFkpDtvsnlqqRqklqapsvkGFDfAkqHlGqhskDdilviqepaplppskkealpiedaevptpks
subfamily_eak_pd Subfamily eak 1223-1300 2.8e-06 21.0 In-house 234-312 (332) alignment 
Range on Protein: 1223-1300
Range on HMM: 234-312/332.0
KPTKGPMlVHCSAGVGRTGTFMAIDMGLQ--QAEKEGGIDIISIINKMRQQRMKMVQTADQYIFVNDAVLESVTCGNTQV
 |.  |. . .. |  |.|.|. ||. ..  .. |.    .  .| |....|.. | .| |. |. ..||. .   | ..
ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1346-1394 3.9e-06 21.0 In-house 45-94 (95) alignment 
Range on Protein: 1346-1394
Range on HMM: 45-94/95.0
ASQNNDKNRSTQFLPRDNYRVPLKGE-HPDYINAVFINGYKEKKAFIIAE
.  |  |||  . .| |  || |      |||||.|..||  |...| |.
seanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq
PTEN_1 1193-1243 4.2e-06 21.7 In-house 96-147 (196) alignment 
Range on Protein: 1193-1243
Range on HMM: 96-147/196.0
QYHFTSWPDHGVPEYAtSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTF
.|.  ...|||.|  . ... . ..... ..  | ..  |||| ||.||.|| 
eylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtv
DUF3377 Domain of unknown function (DUF3377) 822-859 5.6e-06 16.0 Pfam-A 29-66 (74) alignment 
Range on Protein: 822-859
Range on HMM: 29-66/74.0
AIAAGIIVPLLLLIIIVIVIIVVVVSKKKKGKHEVVYY
  |. ...||.|.. |.......|  |.|    ...|.
vnavaVviPlvLalCiLvlvytivqfkrkgtprrllyc
fn3 Fibronectin type III domain 282-353 7.5e-06 19.2 Pfam-A 2-77 (85) alignment 
Range on Protein: 282-353
Range on HMM: 2-77/85.0
TPTGLTATRLstGLAQVRLSWSTV----SGATGYEVYYQLS-SNT-PVSVSTTSYTTINILAALSQGSTYTFYVVSYG
 |..|...    .  ...||||      .  ||||| |. . ..  ........ ||  .|  |  |..|.| | .. 
aPenlsvsev..tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavn
DUF4448 Protein of unknown function (DUF4448) 754-850 8.7e-06 14.0 Pfam-A 104-185 (189) alignment 
Range on Protein: 754-850
Range on HMM: 104-185/189.0
VTLTPTIVSSTSMV-S-TVmqtstviqastliQTSTVMQASTSHTSGTPVTTSAPSSNPTessA---GgsstSAIAAGIIVPLLLLIIIVIVIIVVVVSK
.||.|..|....     ..             . .||. .|...   .. . .|.... .   .        ...|. |..|. .......|...... .
itlqpdavpdneefaedsl.............kGptVsltskkdlkkkeksekasnnkse...eegsd....ekyalaialPvvvvvaalgvllfllinr

KK
||
kk