Gene PTPRD-80 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP140_AA protein Get Run
AqueP140_AA_202-313 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 207-313 1.9e-47 157.2 In-house 12-117 (564) alignment 
Range on Protein: 207-313
Range on HMM: 12-117/564.0
AHIANMHADDDYLFSVEYPTVEPQHHPTRDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRM
.|.|...|..|. |. || ..|.... | .||..| | ..|||| ||.|||||||.|.. ....|||||||..||||.|..||||.|||....| |||||
ehvaklkansdlkfeeeykkieegqqftweaankpaN.kaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRm

IWEQKTE
.|||...
vweqnss
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 207-312 8e-42 138.4 In-house 9-114 (318) alignment 
Range on Protein: 207-312
Range on HMM: 9-114/318.0
AHIANMHADDDYLFSVEYPTV-EPQHHPTRDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWR
 |....... . |.| ||  .   ....|.  . .| | ..||||.|||||||.||||..  ...|||||||||||||....||||.|.|.|. | ||||
shvrrlresGelllseeyerlsrseetvtslkslepvn.kaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWr

MIWEQKT
|.|||..
mvWeqns
subfamily_PTPRG_pd Subfamily PTPRG 207-313 5.1e-39 128.9 In-house 8-117 (563) alignment 
Range on Protein: 207-313
Range on HMM: 8-117/563.0
AHIANMHADDDYLFSVEYPTVEPQHHPT---RDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGS-DYINANYIDGYKKENAYIASQGPVPQSIVD
 |.|..|||.|  || |.  .. .. ..    .....|.| ..||||.||.|||.|||||.. |.. .. |||||||||||.|..|.||.|||... . |
khvaslhadgdigfseefealqsetiskdldaehsqkpen.krKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfdd

FWRMIWEQKTE
||||||||...
FWrmiWeqnva
subfamily_PTPRB_pd Subfamily PTPRB 206-313 1.3e-36 121.2 In-house 13-120 (293) alignment 
Range on Protein: 206-313
Range on HMM: 13-120/293.0
DAHIANMHADDDYLFSVEYPTVEPQHH-PTRDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFW
..|...|.||.|. || || ...   .  . .||... | |.||||||||.||||||||..  . .||||||||||.||. .. .||.|||.|... |||
eehvkkmkadsdlrfseeyeelkavgkdqavkaaelavn.raknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfW

RMIWEQKTE
||.||.|..
rmvwekkss
0051299 (Phosphotyrosine protein) phosphatases II 207-313 8.3e-35 116.0 In-house 12-118 (288) alignment 
Range on Protein: 207-313
Range on HMM: 12-118/288.0
AHIANMHADDDYLFSVEYPTVEPQHHPTRDAARHPDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRM
 .. ...|.. ...  |. .. .. ..    | .  . ..||||..||.||||||||.  ..|.|||||||.|||||......|| ||| |... |||||
klvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrm

IWEQKTE
.|||...
vweqnvr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 207-314 1.8e-34 114.1 In-house 10-117 (288) alignment 
Range on Protein: 207-314
Range on HMM: 10-117/288.0
AHIANMHADDDYLFSVEYPTVEP-QHHPTRDAARHPDNArKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWR
|..|...|..   || || .. . ... . .|.|.. || ||||| |||.||. ||||.. ....|.|||||.||||.||...|||.|||..... |||.
akvakksarnrtgfseeynsLaalektksvtagrlavna.kknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MIWEQKTET
...|.||.|
lvyenktst
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 208-312 2.4e-34 113.7 In-house 5-109 (281) alignment 
Range on Protein: 208-312
Range on HMM: 5-109/281.0
HIANMHADDDYLFSVEYPTVEP-QHHPTRDAARHPDNArKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRM
|.......|.  |  || ...  . . |  |.....|  .||||.|| |||..|||.|.. .   .||||||...|||.|..|||.|||||.|.|.||.|
hlkqlsqndnaGfieeyeklaaigvdntataskadenv.lknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

IWEQKT
.|||| 
vweqkv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 207-312 2.9e-34 113.6 In-house 12-116 (319) alignment 
Range on Protein: 207-312
Range on HMM: 12-116/319.0
AHIANMHADDDYLFSVEYPTVEPQHHPTRDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRM
 .. ....  . |.  |. ...     | | | ...| .|||||.||||||..||.|.| ..|.|||||||..||||......|| |.|. . | |||||
erlkalastgetllekefkllkeavndtfdsaskeen.kkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrm

IWEQKT
.||...
vWeees
0040438 (Phosphotyrosine protein) phosphatases II 208-313 1.5e-33 111.9 In-house 8-112 (317) alignment 
Range on Protein: 208-313
Range on HMM: 8-112/317.0
HIANMHADDDYLFSVEYPTVEPQHHPTRDAARHPDNARkKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMI
..  ... | .... |. ..  ....|.. |..|.|   ||||..|| ||||||||. ......||||||.|.||... ...|| ||| |... |||||.
alldllksdftalleefedllslkldtysvaelpenkd.knrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmv

WEQKTE
|||...
weqgvt
subfamily_PTPRA_pd Subfamily PTPRA 207-314 5e-33 109.4 In-house 21-128 (330) alignment 
Range on Protein: 207-314
Range on HMM: 21-128/330.0
AHIANMHADDDYLFSVEYPTVEP-QHHPTRDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWR
  |    |||  ||  |. ..   . . | ..| . .| ..|||. ||| ||.||| |..   |. |||||| .|||||. . .||.|||  ... ||||
eeirirsaddnklfreefnalPagpiqatlelaskeen.keknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwr

MIWEQKTET
||||||. |
miweqksat
0043336 (Phosphotyrosine protein) phosphatases II 208-313 3.9e-32 107.3 In-house 10-114 (278) alignment 
Range on Protein: 208-313
Range on HMM: 10-114/278.0
HIANMHADDDYLFSVEYPTVEPQHHPTRDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMI
......... .|.. |. ..  ....|.. |..|.| ..||||..||.||||||||. ......||||||.|.|||.. ...||.||| |... |||||.
allelllnlktllllefeellsfkldtysiallpen.kdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmv

WEQKTE
||....
welgvt
0050432 (Phosphotyrosine protein) phosphatases II 202-313 1e-31 105.9 In-house 26-134 (308) alignment 
Range on Protein: 202-313
Range on HMM: 26-134/308.0
TELPDAHIANMHADDDYLFSVEYPTVEPQHHPTRDAARHPDNARKKNRYTNILAYDHSRVKLtedpNvPGSDYINANYIDGY--KKENAYIASQGPVPQS
. . | . . ..|.| .|.. |. ..  .  .    .    . ..||||..||.||||||||    . .|||||||.|.|||  |.....|| ||| |..
lsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpnt

IVDFWRMIWEQKTE
. |||||.|||...
vedFwrmvweqnvr
0039614 (Phosphotyrosine protein) phosphatases II 193-313 1.8e-31 105.2 In-house 7-127 (297) alignment 
Range on Protein: 193-313
Range on HMM: 7-127/297.0
GETELPDGETELPDAHIANMHADDDYLFSVEYPTVEPQHHPtRDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNV-PGSDYINANYIDGYKK-ENAYI
  .| ..  ..  |...  ..|.. .|.  |. ..  . .. .  |..| | ..||||..||.||||||||.  ..| ..||||||.|.|||..  ...|
allesipiplsvldlllllekansktllllefeellslkpd.ysiallpen.kdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfI

ASQGPVPQSIVDFWRMIWEQKTE
|.||| |... |||||.|||...
atqgPlpetvedFwrmvweqgvt
DSPc_SM00195 239-313 1.8e-31 104.8 In-house 21-95 (263) alignment 
Range on Protein: 239-313
Range on HMM: 21-95/263.0
RHPDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
 . .. ..||||.||| |||.||||..... .||||||||||.|..|...||| ||| |. . |||||.||.|..
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk
PTPc_SM00194 239-313 1.8e-31 104.8 In-house 21-95 (263) alignment 
Range on Protein: 239-313
Range on HMM: 21-95/263.0
RHPDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
 . .. ..||||.||| |||.||||..... .||||||||||.|..|...||| ||| |. . |||||.||.|..
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk
subfamily_PTPN9_pd Subfamily PTPN9 234-312 8e-31 102.2 In-house 33-110 (297) alignment 
Range on Protein: 234-312
Range on HMM: 33-110/297.0
TRDAARHPDNARkKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
| .|.... | . |||||..| ||..||.|.. .. . |||||||..||||...|.|| |||... . |||||.|||..
tflasklranle.knrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqev
0036941 (Phosphotyrosine protein) phosphatases II 212-313 1.2e-30 102.2 In-house 7-104 (297) alignment 
Range on Protein: 212-313
Range on HMM: 7-104/297.0
MHADDDYLFSVEYPTVEPQHHPTRDAARHPDNARKKNRYTNILAYDHSRVKLtedpNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQK
..... .|.. |. .. | ...    . .  . ..||||..||.|||.||||    . .|||||||.|.|||. ....|| ||| |... |||||.|||.
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

TE
..
vt
0046845 (Phosphotyrosine protein) phosphatases II 233-313 1.7e-30 101.8 In-house 18-103 (284) alignment 
Range on Protein: 233-313
Range on HMM: 18-103/284.0
PTRDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNV-PGSDYINANYIDGY-----KKENAYIASQGPVPQSIVDFWRMIWEQKTE
 ....|..| | ..||||..||.||||||||.  ..  ..||||||.|.|||     ......|| |||.|... |||||.|||...
lslsvallpen.lsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 231-314 1.8e-30 101.2 In-house 40-126 (298) alignment 
Range on Protein: 231-314
Range on HMM: 40-126/298.0
HH----PTRDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTET
 .     . ..||.|.| .|||||..|.|.|.||| |... .   |||||| ....||..||.||.|.|......|||||..|.. .|
sseieeeekevarkpen.kkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigt
subfamily_Ptp69D_pd Subfamily Ptp69D 208-313 2.5e-30 100.6 In-house 12-117 (307) alignment 
Range on Protein: 208-313
Range on HMM: 12-117/307.0
HIANMHADDDYLFSVEYPTVEPQHHPTRDAARHPDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMI
 . . . | |...  || ..| .. .    . . ..   |||| .| |.|. ||||.. .    ||||||..| |||... .||.|.|| . | ||||||
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmi

WEQKTE
.||. .
aeqevt
0047943 (Phosphotyrosine protein) phosphatases II 213-313 2.7e-30 101.2 In-house 7-103 (273) alignment 
Range on Protein: 213-313
Range on HMM: 7-103/273.0
HADDDYLFSVEYPTVEPQHHPTRDAARHPDNARKKNRYTNILAYDHSRVKLtedpNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
.... .|.  |. .. .. ..    .    . ..||||..||.||||||||    . .|||||||.|.|||......|| ||| |... |||||.|||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

E
.
r
subfamily_PTPRK_pd Subfamily PTPRK 208-312 2.9e-30 100.2 In-house 12-111 (314) alignment 
Range on Protein: 208-312
Range on HMM: 12-111/314.0
HIANMHADDDYLFSVEYPTVEPQhhptRDAARHpDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMI
.|| ... . | |  || ..        |||.. |. |.|||...|||||.|||.|.   . | ||||||..||.||. .|.|. |||... . ||||..
siallkraegygfkeeyeslfeg....wdaakk.denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlv

WEQKT
.....
ydenc
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 214-313 3.9e-30 100.3 In-house 30-130 (319) alignment 
Range on Protein: 214-313
Range on HMM: 30-130/319.0
ADDDYLFSVEYPTVEPQHHPTRDAA-RHPDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
 ||   . ||.  .  .  .  | .    |. . |||..||||.|...|||     . .|||||| ...||.... |||.||| . .. ||||||||...
dddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

E
 
s
0045450 (Phosphotyrosine protein) phosphatases II 207-313 5.4e-30 100.6 In-house 16-133 (307) alignment 
Range on Protein: 207-313
Range on HMM: 16-133/307.0
AHIANMHADDDYLFSVEYPTVEPQHHP---TRDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNV-PGSDYINANYI--------DGYKKENAYIASQG
 ... ...|. ...  |. .. .....   ....|..| | ..||||..||.|||.||||.  ..  ..||||||.|.        |||.. ...|| ||
llvllllldfltgllkefekllsvtvfllgeysiallpen.kdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

PVPQSIVDFWRMIWEQKTE
| |... |||||.|||...
PlpetvedFwrmlweqgvt
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 242-313 2.7e-29 97.6 In-house 23-94 (284) alignment 
Range on Protein: 242-313
Range on HMM: 23-94/284.0
DNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
|. . |||...|||.|...|||     . .|||||| .| ||.... |||.||| . .. ||||||||... 
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncs
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 215-312 7.6e-29 95.6 In-house 21-117 (315) alignment 
Range on Protein: 215-312
Range on HMM: 21-117/315.0
DDDYLFSVEYPTVE-PQHHPTrDAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
     |  .| ..   | ||  | |..  | ..|||| ||.|||.|||.|    | |.|||.|||.||||.|.. |||.||| ..|. ||||...|.. 
stkngfkqdyesipggqlhpl.dvakkien.kqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedi
subfamily_PTPN12_pd Subfamily PTPN12 237-312 3.9e-28 93.2 In-house 34-108 (290) alignment 
Range on Protein: 237-312
Range on HMM: 34-108/290.0
AARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
|.... | .||||| .|| ||.|||.|... ...||||||||.| | ... .|||.|||.|. . ||||||||...
agekeen.vkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 237-313 4.1e-28 93.2 In-house 3-78 (250) alignment 
Range on Protein: 237-313
Range on HMM: 3-78/250.0
AARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
 |..|.| ..||||..|.|.|.||| | ..     |||||| ...||....|.||.|||....|.|||||..|.|..
vakkpqn.keknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksg
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 206-313 4.8e-28 93.2 In-house 10-115 (305) alignment 
Range on Protein: 206-313
Range on HMM: 10-115/305.0
DAHIANMHADDDYLFSVEYPTVEPQhHPTRDAARHpDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWR
.|.| ......|  . ..| ..  . . . |  .. .. ..|||...|  .|..|..|||..... ||||||.|.||||....||..|||... ..||||
aayikearvysdkgleaqykslyee.eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWr

MIWEQKTE
.|.| |..
liveekvs
subfamily_PTPN6_pd Subfamily PTPN6 228-312 5.3e-28 92.9 In-house 39-123 (306) alignment 
Range on Protein: 228-312
Range on HMM: 39-123/306.0
EPQHHPTRDAARHPDNaRKKNRYTNILAYDHSRVKLTeDPNVPGSDYINANYIDG--YKKENAYIASQGPVPQSIVDFWRMIWEQKT
| ..  .|. ...|.| ..|||| ||| .||.||.|. .|.||||||||||||..   .....|||.|| ... . |||||.|....
eakkllsrkegakpen.keknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqens
Y_phosphatase Protein-tyrosine phosphatase 245-313 2.2e-27 91.4 Pfam-A 2-68 (235) alignment 
Range on Protein: 245-313
Range on HMM: 2-68/235.0
RKKNRYTNILAYDHSRVKLtedPNVPG-SDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
.|||||..||.||..||||    . .| ||||||||..|||.....||.|||....| |||||.|..|..
kkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvk
Y_phosphatase Protein-tyrosine phosphatase 245-313 2.2e-27 91.4 In-house 2-68 (235) alignment 
Range on Protein: 245-313
Range on HMM: 2-68/235.0
RKKNRYTNILAYDHSRVKLtedPNVPG-SDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
.|||||..||.||..||||    . .| ||||||||..|||.....||.|||....| |||||.|..|..
kkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvk
0042113 (Phosphotyrosine protein) phosphatases II 245-313 5.1e-27 90.3 In-house 10-78 (245) alignment 
Range on Protein: 245-313
Range on HMM: 10-78/245.0
RKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
..||||..||.|||.||||..|.. ..||||||.|.|||.  . .||.||| |... |||||.||.. .
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgit
0040439 (Phosphotyrosine protein) phosphatases II 245-313 5.4e-27 90.4 In-house 12-80 (249) alignment 
Range on Protein: 245-313
Range on HMM: 12-80/249.0
RKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
..||||..||.||||||||.  |....||||||.|||||.  ...|| ||| |... |||||.||.. .
kdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgit
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 244-312 2.2e-26 87.3 In-house 38-105 (287) alignment 
Range on Protein: 244-312
Range on HMM: 38-105/287.0
ARKKNRYTNILAYDHSRVKLTEDPNVpGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
| |||||...| .|..|| |.....  |||||||||. .|....|.||.|||.. .. ||||...|...
avkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrs
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 218-314 3.2e-26 86.9 In-house 19-114 (315) alignment 
Range on Protein: 218-314
Range on HMM: 19-114/315.0
YLFSVEYPTV-EPQHHPTRdAARHPDNArKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTET
 ||| |.  . .|. ...| .||...|  ||||| ||| .|..||||    . | |||||| || ......|||||||| . |. |||||....|. |
alfseefhdlpdPdiyrqr.varetinf.kknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtt
0045098 (Phosphotyrosine protein) phosphatases II 216-313 9.6e-26 86.2 In-house 5-90 (278) alignment 
Range on Protein: 216-313
Range on HMM: 5-90/278.0
DDYLFSVEYPTVEPQHHPTRDAARHPDNARKKNRYTNILAYDHSRVKltedpnvpgsDYINANYIDGYkkENAYIASQGPVPQSIVDFWRMIWEQKTE
... .. |.  . ....| .       . ..||||..||.|||||||          |||||.|||||   ...|| ||| |. . |||||.||....
asldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 218-313 1e-24 81.7 In-house 20-114 (392) alignment 
Range on Protein: 218-313
Range on HMM: 20-114/392.0
YLFSVEYPTV-EPQHHPTRdAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
 ||. |.  . .|. .|.. .|....|  ||||| ||| || .||||    ..| |||.|| ||.... |.|||||||| . |. |||||...... 
alffeefhdlpgpdiypqt.vaqkein.lkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvt
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 242-313 3.3e-24 80.1 In-house 46-117 (439) alignment 
Range on Protein: 242-313
Range on HMM: 46-117/439.0
DNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
.  . |||| .. |.||.|| | | | || | |||||||.|| ... |||.|||  ..  ||||...|.|| 
eydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 208-309 4.1e-24 80.3 In-house 13-115 (325) alignment 
Range on Protein: 208-309
Range on HMM: 13-115/325.0
HIANMHADDDYLFSVEYPTVEPQHHPTRDAARHPDNArKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMI
|. . .|.|.  |. |.  . ..   .. .| .|.|  .|||. |..|.|.||| |    . | ||||||.|.  .|| . ..|.| | ...| |.||..
hvekkkaqdqdgfahefgllpsddgiakkvamkpenk.aknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlv

--WE
  |.
ldWr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 219-314 4.6e-24 79.4 In-house 19-113 (515) alignment 
Range on Protein: 219-314
Range on HMM: 19-113/515.0
LFSVEYPT-VEPQHHPTRDAaRHpDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTET
||| |.     |. .|   | .  .   ||||| ||| || .||||    . | |||.|| || ... ..|||||||| . |. ||||....... |
lfseefhdlpgpniypqtva.qe.einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvtt
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 243-313 5.8e-24 79.6 In-house 27-99 (274) alignment 
Range on Protein: 243-313
Range on HMM: 27-99/274.0
NARKKNRYTNILAYDHSRVKL-TEDPNVPGSDYINANYIDGYK-KENAYIASQGPVPQSIVDFWRMIWEQKTE
 . .||||..||  ..||| | .|... . |.||||||| ||. ...||.| |||.|. . ||||||......
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevq
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 208-312 1.8e-22 74.6 In-house 10-116 (290) alignment 
Range on Protein: 208-312
Range on HMM: 10-116/290.0
HIANMHADDDYLFSVEYPTVEPQHHPTRDAARHPDNARKKNRYTNILAYDHSRVKLTEDPNVPG--SDYINANYIDGYKKENAYIASQGPVPQSIVDFWR
..|| ||  .  |  .. ...  ...         . ...||..||. ||  |. | . .. .    .|||| ||.|||....||| ||||.. .||||.
fvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWk

MIWEQKT
.||..|.
liwqekv
subfamily_ptpA1_pd Subfamily ptpA1 241-311 4.2e-22 73.4 In-house 44-113 (418) alignment 
Range on Protein: 241-311
Range on HMM: 44-113/418.0
PDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKeNAYIASQGPVPQSIVDFWRMIWEQK
      ||||||||  .|.||.| .  .  ||||||||||||    . .|..|||.|..| |||||.||..
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenr
0037934 (Phosphotyrosine protein) phosphatases II 244-313 7.5e-22 73.5 In-house 10-74 (243) alignment 
Range on Protein: 244-313
Range on HMM: 10-74/243.0
ARKKNRYTNILAYDHSRVKLtedpnvPGSDYINANYIDGYKKenaYIASQGPVPQSIVD----FWRMIWEQKTE
 ..||||..||.||||||||      .||||||||.|.....   .||.||| |... |    ||||.||....
nlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgit
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 240-313 1e-21 72.2 In-house 14-90 (270) alignment 
Range on Protein: 240-313
Range on HMM: 14-90/270.0
HPDNAR--KKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKE-NAYIASQGPVPQSIVDFWRMIWEQKTE
 |. ||  | |||..||   ..||.| |  . . . ||||||. |...| ..|||..||.| .. .|||||||.|..
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvt
subfamily_PTPN3_pd Subfamily PTPN3 236-313 1.1e-21 72.0 In-house 34-110 (280) alignment 
Range on Protein: 236-313
Range on HMM: 34-110/280.0
DAARHPDNArKKNRYTNILAYDHSRVKLTEDPNvpgsDYINANYID----GYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
.||| |.|. .|||| .||.||. ||||.| ..    |||||||..    . .  | |||.|||....  |||.|.||||..
saarkpenl.sknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 246-313 1.6e-21 71.7 In-house 53-118 (297) alignment 
Range on Protein: 246-313
Range on HMM: 53-118/297.0
KKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKenAYIASQGPVPQSIVDFWRMIWEQKTE
.|.||.||| || |||||    . | |||.|| .. |.|.   .|..| | .... |||.|...... 
eksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvs
subfamily_PTPN1_pd Subfamily PTPN1 230-313 2e-21 71.0 In-house 20-97 (290) alignment 
Range on Protein: 230-313
Range on HMM: 20-97/290.0
QHHPTRDAaRHPDNaRKKNRYTNILAYDHSRVKLTEDPNvpgsDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
...|||.| ..| | |..||| ..  |||||.|| .. |    |||||. ..  . .  || .|||.|. .  ||.|.||||. 
sdfptrea.klpen.rnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqksk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 241-312 3e-21 70.6 In-house 44-111 (287) alignment 
Range on Protein: 241-312
Range on HMM: 44-111/287.0
PDNARKKNRYTNILAYDHSRVKLTEDPNvpgsDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
  . ..|||.|.|| .|  || | .  .    ||||| .|||||...|.|....|. . ...||..|.... 
asqnkdknRltqilvpdnyrvllkgehp....dyinavfidgykekkafiiaesPmfntarnfWkliddrnv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 208-312 4.7e-21 69.8 In-house 8-110 (301) alignment 
Range on Protein: 208-312
Range on HMM: 8-110/301.0
HIANMHADDdylFSVEYPTVEPQhHPTRDAARHPDNARKKNRYTNILAYDHSRVKLTEDPN--VPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWR
| |..|...   |. .| ... . .. .    . .. .. ||. ||  ||. |. |.. ||  .   .||||.|||||......||.|||. . .|||||
hvaakhsnk...feeqykelkeg.edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWr

MIWEQKT
.||..|.
liwqekp
subfamily_PTPN13_pd Subfamily PTPN13 242-313 8.4e-21 69.4 In-house 35-103 (273) alignment 
Range on Protein: 242-313
Range on HMM: 35-103/273.0
DNARKKNRYTNILAYDHSRVKLTEDPNvpgsdYINANYIDGY--KKENAYIASQGPVPQSIVDFWRMIWEQKTE
.. ..|||| |.| ||..|||| .. .     ||||..|     |.|  |||.|||.|... |||.|.||||.|
kenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkae
subfamily_PTPRN_pd Subfamily PTPRN 233-310 1.3e-20 68.4 In-house 46-123 (297) alignment 
Range on Protein: 233-310
Range on HMM: 46-123/297.0
PTRDAARHPDNArKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYI-DGYKKENAYIASQGPVPQSIVDFWRMIWEQ
 |...|....|. ||||....|.||||||||.|. .   ||||||  | |   .. ||||.|||..... |||.|.|||
stkevakaeknv.kknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweq
0049772 (Phosphotyrosine protein) phosphatases II 233-311 1.7e-20 69.4 In-house 36-120 (314) alignment 
Range on Protein: 233-311
Range on HMM: 36-120/314.0
PTRDAARHPDNaRKKNRYTNILAYDhSRVKLtEDPNVPGSDYINANYIDGYkkeNAYIASQGPVPQSIVDF----------WRMI--WEQK
 |. .|... | |.||||..|| .| .||.|    .| |||||||.|.||.   ...||.||| .  .|||          |||.  ....
ltilvadlfln.rdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdln
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 244-311 6.3e-20 66.3 In-house 8-76 (239) alignment 
Range on Protein: 244-311
Range on HMM: 8-76/239.0
ARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKK-ENAYIASQGPVPQSIVDFWRMIWEQK
 . ||||.||..|||||| | .  | | ||||||.|.  |    .||||.|| |  |  |||||.|...
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqer
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 245-311 7.6e-20 66.1 In-house 8-75 (239) alignment 
Range on Protein: 245-311
Range on HMM: 8-75/239.0
RKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKK-ENAYIASQGPVPQSIVDFWRMIWEQK
. ||||.||..|||||| | .  | | ||||||.|.  |    .||||.|| |  |  |||||.|...
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqer
subfamily_PTPN14_pd Subfamily PTPN14 216-313 1.1e-19 65.6 In-house 22-119 (300) alignment 
Range on Protein: 216-313
Range on HMM: 22-119/300.0
DDYLFsVEYPTVEPQH-HPTRDAARHPDNArKKNRYTNILAYDHSRVKLTEDPNVpGSDYINANYIDGY--KKENAYIASQGPVPQSIVDFWRMIWEQKT
.  .| .||  . ... . . ..|. |.|| .|||. ..| |...||.|.   .   ..||||  |      ||  ||..|||... . |||.|.|||..
egkvf.teyeripkkredallstaklpena.eknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgv

E
.
q
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 239-312 1.9e-19 64.6 In-house 29-101 (297) alignment 
Range on Protein: 239-312
Range on HMM: 29-101/297.0
RHPdNARKKNRYTNILAYDHSRVKLTEdpNVPGSDYINANYIDGYKK--ENAYIASQGPVPQSIVDFWRMIWEQKT
. . .. .||||..|||.| .||||     ....|||||.|.   ..  .  || .|||. ... |||....||  
krn.sslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdv
subfamily_CG7180_pd Subfamily CG7180 238-313 3.3e-19 63.6 In-house 36-111 (296) alignment 
Range on Protein: 238-313
Range on HMM: 36-111/296.0
ARHPDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
. .  . |.|||. ... ||. || |..      |||||| |.|.. |...||  ..|. ... .|||........
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 244-312 5.9e-19 63.2 In-house 3-70 (237) alignment 
Range on Protein: 244-312
Range on HMM: 3-70/237.0
ARKKNRYTNILAYDHSRVKLTEDPNvpGSDYINANYIDGYKK-ENAYIASQGPVPQSIVDFWRMIWEQKT
 . |||| || ||||||| |    .  |||||||.|..|.    . |||.|||.  |  |||.|.|..| 
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekc
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 240-312 1.6e-18 61.6 In-house 29-100 (283) alignment 
Range on Protein: 240-312
Range on HMM: 29-100/283.0
HPDNARKKNRYTNILAYDHSRVKLTEDPNvpgsDYINANYID---GYKKENAYIASQGPVPQSIVDFWRMIWEQKT
  |. ..|||. .|...|  ||.|  ...    ||||| .|     ||... ||..|.|. . .||||.|....| 
sadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki
subfamily_PTPN23_pd Subfamily PTPN23 244-313 4.2e-18 60.2 In-house 43-109 (288) alignment 
Range on Protein: 244-313
Range on HMM: 43-109/288.0
ARKKNRYTNILAYDHSRVKLTedpnVPGSDYINANYIDGYKKE-NAYIASQGPVPQSIVDFWRMIWEQKTE
  .|||...|| |||.||||         ||||| .. .       .||.|.| .... |||.|..|||..
yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkss
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 238-312 4.8e-17 56.5 In-house 32-106 (281) alignment 
Range on Protein: 238-312
Range on HMM: 32-106/281.0
ARHPDNaRKKNRYTNILAYDHSRVKLTE-DPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
  .| |  |||||.|| . | |||.|    ||   .||| ||||     .  || .|||  ..  |||||||...|
fnqpvn.nkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqent
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 245-313 5e-17 56.4 In-house 53-120 (310) alignment 
Range on Protein: 245-313
Range on HMM: 53-120/310.0
RKKNRYTNILAYDHSRVKLTEDPNVpGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
 .||||....  | |||||. |      ||| |||.      ...| ||||. ..|.||||||.....|
mhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqerae
0041856 (Phosphotyrosine protein) phosphatases II 245-312 9.4e-17 56.6 In-house 2-59 (182) alignment 
Range on Protein: 245-312
Range on HMM: 2-59/182.0
RKKNRYTNILAYDHSRvkltedpnvpGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
..||||..|| |||||          ..||||||...|. . . .|| ||| .... ||.||..|.. 
ldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 246-311 5.9e-16 53.1 In-house 49-128 (350) alignment 
Range on Protein: 246-311
Range on HMM: 49-128/350.0
KKNRYTNILAYDHSRVKLTEDP--------NVPGSDYINANYIDGY----KKENA--YIASQGPVPQSIVDFWRMIWEQK
 ||||.||| |.|||||| . .         . ..|||||||.       . .    ||| |.|.|. . ||...| . |
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnk
subfamily_CG42327_pd Subfamily CG42327 239-312 2.6e-15 50.9 In-house 23-97 (319) alignment 
Range on Protein: 239-312
Range on HMM: 23-97/319.0
RHPDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKK-ENAYIASQGPVPQSIVDFWRMIWEQKT
  |  ...|.|. |..   ..|| | . .. . . |..|.|. ||.. .| |||.| .  .|  ||||..|||..
evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqs
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 239-312 3.4e-15 50.8 In-house 28-97 (267) alignment 
Range on Protein: 239-312
Range on HMM: 28-97/267.0
RHPDNARKKNRYTNILAYDHSRVKLTEDPNVpgsdYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
  . . ...||. . | ||..|| | .  .     |||| |..|||..||.|. |.|. ..| ||. .| .|| 
siaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkv
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 207-294 5.8e-15 49.3 In-house 12-95 (95) alignment 
Range on Protein: 207-294
Range on HMM: 12-95/95.0
AHIANMHADDDYLFSVEYPTVEPQHHPTRDAArHPDNARKKNRYTNILAYDHSRVKLTEDPNvpgSDYINANYIDGYKKENAYIASQG
.|. .||.. |  |  |. ..      .  .    .    |||. ||. || .|| ||   .   |||||| ..||| . |.|||.||
shvlemhsnsdqefdnefksismtsgapytvg.sseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 242-312 2.8e-13 44.2 In-house 53-119 (290) alignment 
Range on Protein: 242-312
Range on HMM: 53-119/290.0
DNA-RKKNRYTNILAYDHSRVKLTEDpnVPGsDYINANYIDGYKkeNAYIASQGPVPQSIVDFWRMIWEQKT
 |.  ||||| ..   | .|| | .    .| ||. |||..| |    .| .||.. ....|.|||. ..|.
kntefkknrykdvvcndktrvilkdG..ydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 236-313 3.7e-12 40.5 In-house 47-122 (305) alignment 
Range on Protein: 236-313
Range on HMM: 47-122/305.0
DAARHPDNARKKNRYTNILAYDHSRVKLTEDPnvpGSDYINANYIDGY-KKENAYIASQGPVPQSIVDFWRMIWEQKTE
.| . .| |  ||||... . |.| ||| . .    |||| |||.      |. .|..|||. |.| .|| |. ..| |
nanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkve
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 236-282 6.9e-12 39.4 In-house 40-85 (440) alignment 
Range on Protein: 236-282
Range on HMM: 40-85/440.0
DAARHPDNaRKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDG
| |  |.| . |||| |||||||||| | |   || |||||| ||.|
diaslpnn.kvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_egg_pd Subfamily egg 241-312 9e-12 39.3 In-house 37-108 (307) alignment 
Range on Protein: 241-312
Range on HMM: 37-108/307.0
PDNARKKNRYTNILAYDHSRVKLTEDPNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
 || ..| |   .   | |||||         |.| ||...|    | .| .| |.  .  |||||..... 
sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeev
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 246-311 9.1e-12 38.9 In-house 50-131 (349) alignment 
Range on Protein: 246-311
Range on HMM: 50-131/349.0
KKNRYTNILAYDHSRVKLTEDPNVPG--------------SDYINANYID--GYKKENAYIASQGPVPQSIVDFWRMIWEQK
 |||| .|| |.|||||| . .. .                |||||||.    .. |. ||| | |.| .. ||...|  ..
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillng
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 243-312 9.6e-12 39.1 In-house 46-108 (303) alignment 
Range on Protein: 243-312
Range on HMM: 46-108/303.0
NARKKNRYTNILAYDHSRVKLTEdpnvpgSDYINANYIDGYKKENAyIASQGPVPQSIVDFWRMIWEQKT
.  .|||.....  |||.|||..      | || |.|..   . .| | .| |....  |||.|| ||| 
knmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 244-313 1.6e-11 38.5 In-house 48-114 (305) alignment 
Range on Protein: 244-313
Range on HMM: 48-114/305.0
ARKKNRYTNILAYDHSRVKLteDPNVPgSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
 ..|||| ..   |. ||||  ..  |  .|| |||.    . . .| .| |. ..  ||| | ...| |
eagknrykdvgcldnnrvkl..egpwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkve
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 244-313 1.7e-11 38.7 In-house 41-108 (307) alignment 
Range on Protein: 244-313
Range on HMM: 41-108/307.0
ARKKNRYTNILAYDHSRVKLTEDPNvpGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
  .||||... . |..|. .. |     |||| |||.    | . .|..|||  ... .|| |. ..| |
ntdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekve
0043147 (Phosphotyrosine protein) phosphatases II 270-312 5.8e-11 37.9 In-house 3-45 (172) alignment 
Range on Protein: 270-312
Range on HMM: 3-45/172.0
PGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
.|||||||.|.|.| . . .|| ||| .  . |||||..|.. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 244-312 6.1e-11 36.4 In-house 34-101 (332) alignment 
Range on Protein: 244-312
Range on HMM: 34-101/332.0
ARKKNRYTNILAYDHSRVKLTedPNVPGSDYINANYIDGYKKENAYIASQGPVPQSI-VDFWRMIWEQKT
    ||   . ..|||||.|.  |.    |. ||...||| |..||| .| |. .     ||||. |.| 
nmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkp
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 245-311 4e-10 34.2 In-house 44-106 (288) alignment 
Range on Protein: 245-311
Range on HMM: 44-106/288.0
RKKNRYTNILAYDHSRVKLTEDPNVpgsdYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQK
  ..||.|.   | .||||..||.     ||.|| .   | ..  | .| |.   |  .|.|. |. 
ptrdryenlprcditrvklsddpdf....yiaanvvssakykrrlicaqaPlngtieelWkmllesd
0051429 (Phosphotyrosine protein) phosphatases II 269-313 9.3e-10 34.1 In-house 1-47 (272) alignment 
Range on Protein: 269-313
Range on HMM: 1-47/272.0
VPGSDYINANYIDGYKK---ENAYIASQGPVPQSIVDFWRMiWEQKTE
.| |.||||....|| .   ......|.|| | .. ||||. .|..  
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgik
0036282 (Phosphotyrosine protein) phosphatases II 271-313 5.7e-09 31.4 In-house 1-38 (174) alignment 
Range on Protein: 271-313
Range on HMM: 1-38/174.0
GSDYINANYIDGYKKENAYIASQGPVPqsivdFWRMIWEQKTE
|||||||...|..   . .||.||| .     ||.|..|.. .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgit
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 245-311 6.1e-09 30.2 In-house 36-99 (285) alignment 
Range on Protein: 245-311
Range on HMM: 36-99/285.0
RKKNRYTNILAYDHSRVKLTEDpnvpGSDYINANYIDGY-KKENAYIASQGPVPQSIVDFWRMIWEQK
   |||... . . .|| | .       ||| |...    | ...||..|||.|... |||.||...|
pdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqek
0044763 (Phosphotyrosine protein) phosphatases II 256-312 5.2e-08 28.2 In-house 2-49 (178) alignment 
Range on Protein: 256-312
Range on HMM: 2-49/178.0
YDHSRVKLTEDPNVPGSDYINANYIDGYkkenAYIASQGPvpqsiVDFWRMIWEQKT
.|..||.|.. .....||||||..|...     |..|..|     .|......|.. 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgi
0046846 (Phosphotyrosine protein) phosphatases II 266-312 6.5e-08 28.1 In-house 6-48 (176) alignment 
Range on Protein: 266-312
Range on HMM: 6-48/176.0
DPNVPGSDYINANYIDGYKkenaYIASQGPVPQSIVDFWRMIWEQKT
.   ...||||||.|.|..    .|| |||.|... ||..|..|.. 
lgldldldyinanlilgsr....piatqgplprtladflemlkelgi
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 245-284 7.4e-08 26.3 In-house 40-78 (244) alignment 
Range on Protein: 245-284
Range on HMM: 40-78/244.0
RKKNRYTNILAYDHSRVKLTEDpNVPGSDYINANYIDGYK
  |||| ||| .|..|| |.   .  ||||||||||.| .
atknryinilpfdetrvilsss.kkegsdyinanyiqgsq
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 243-310 9.5e-08 25.9 In-house 36-108 (347) alignment 
Range on Protein: 243-310
Range on HMM: 36-108/347.0
NARKKNRYTNILAYDHSRVKLTED-----PNVPGSDYINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQ
.. .|||  .    | .|| |. .     .  .   |||| .|   . .. || .| |.|... |||.|.   
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvt
Bcl-2 Apoptosis regulator proteins, Bcl-2 family 125-172 1.6e-07 17.9 Pfam-A 17-65 (101) alignment 
Range on Protein: 125-172
Range on HMM: 17-65/101.0
QVLSNQVKLFSEKEEKDAMRAAMNEIFSN-QVKFGKILAFGALHCHLCL
. |..|... ...|....... ..|.||. .. .|.|.|. |. ..|. 
enlleqlnietpeeaselfaevaeelfsdgginWGRivallafagalak
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 246-307 1.9e-07 25.1 In-house 45-102 (312) alignment 
Range on Protein: 246-307
Range on HMM: 45-102/312.0
KKNRYTNILAYDHSRVKLTEDPNVpgsdYINANYIDGYKKENAYIASQGPVPQSIVDFWRMI
  ||| ||  .|  |  |. | |     || ||..    | . ....|||. .... ||.. 
dlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqla
DUF4206 Domain of unknown function (DUF4206) 62-171 2.1e-06 13.8 Pfam-A 40-148 (202) alignment 
Range on Protein: 62-171
Range on HMM: 40-148/202.0
ETNKRLEEKLKNPTIDLQDQNAALAENKREMEHLQ---DQISSTSvQLLMKREESEAMKANINKGKQVLSNQVKLFSEKEEKDAMRAAMNEIFSNQVKFg
.... ||.  ..| .||.. |..| |...|.....    .... . ..|.. .|.|..|..... .. | ..|.|.| ..  .  .....|  .. .|. 
aakellesieekplldlkelnpslyekvkeLakvrklrkklkllk.eylktCreaeeekkklkqsreylledvelysladlvevkkgkllesleevikk.

kILAFGAlHCHLC
 . .    .|.||
.aeeHve.eCelC
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 245-313 3.8e-06 20.9 In-house 51-116 (301) alignment 
Range on Protein: 245-313
Range on HMM: 51-116/301.0
RKKNRYTNILAYDHSRVKLTEDPN-VPgsdyINANYIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKTE
..|.|| ..    .. |.. .| . ||    | ||.|.   . . .||.|||....  ||| |.   . |
kdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydve
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 281-311 6.6e-06 19.7 In-house 230-260 (440) alignment 
Range on Protein: 281-311
Range on HMM: 230-260/440.0
DGYKKENAYIASQGPVPQSIVDFWRMIWEQK
.|| | ||.||.| |.  ...||||.. . .
egyskknafiatqmpldstvldfwrlvhdyr
0051082 (Phosphotyrosine protein) phosphatases II 271-312 7.5e-06 21.2 In-house 2-34 (151) alignment 
Range on Protein: 271-312
Range on HMM: 2-34/151.0
GSDYINANYIDGYkkenaYIASQGPVPqsivDFWRMIWEQKT
 |||||..|..|.     ...|.|| .    ||.....|.. 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgi
0049260 (Phosphotyrosine protein) phosphatases II 279-312 8.4e-06 21.1 In-house 1-34 (152) alignment 
Range on Protein: 279-312
Range on HMM: 1-34/152.0
YIDGYKKENAYIASQGPVPQSIVDFWRMIWEQKT
.||||.. ...|| ||| |... |||||..|.. 
fidgyampfefiatqgpgpntladfwrmlkelgi