Gene PTPRD-20 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP141_AA protein Get Run
AqueP141_AA_186-451 phosphatase_domain Get Run
AqueP141_AA_457-728 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 454-736 7.3e-149 489.4 In-house 6-287 (287) alignment 
Range on Protein: 454-736
Range on HMM: 6-287/287.0
MIGKLSEQDPETGQTGYNKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKM
..|.........|..|...||||||||||..||||||||||||||||.||.|.|||.||.|||..|.|||||..|.|||.|||||||||||.|.|||||.
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkl

IEDINVTAIVMLCQEKENDEEVCYKYWPTEATeVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNK
|.| ||||||||||||||||||||.|||.|.. |..|||.|.||||| .. |.||..|.|||.| |....|.||||| |. .|.||..|.||...|||.|
iddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk

TQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYSNF
|||..|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|..||..|||||..||.|
tqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 183-452 4e-123 405.0 In-house 1-266 (287) alignment 
Range on Protein: 183-452
Range on HMM: 1-266/287.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHN-DLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFIDGYSSAYRYIATQGP
||||.|||||||.|||...|.|..|...... . ...|.|......||..||....||.|..|..||      |...|||||.|||||......|....|
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

MANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHG-VPEYAT
|.||...||.||.......|||.....|  ...|.||||...||..|.....|....|  .|..|.|...  ..........||..|.|...| |.|..|
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

SILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
..|......|...|.......||||..|||...|.|..........||.||........|.|.. .||| ..
illvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveq
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 460-734 5.3e-116 381.5 In-house 12-290 (290) alignment 
Range on Protein: 460-734
Range on HMM: 12-290/290.0
EQDPETGQTGYNKQFTVLEQvTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK---GQ---QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKM
...  .|..|...||..|.. .... .||....|.|| .||.......|..|..|.   |.   . .||||.|.. |||.|..|....|...|...|||.
anghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

IEDINVTAIVMLCQEKENDEEVCYKYWPTEATEViFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNK
| . .||.||||....|.....|..|||.. |.  .||.|||||||| .. |.||..|.||| ..|....|.||||| |...|.||..|.||...|||.|
iwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

TQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
|||..|||||||||||||||||.|||||||||||||||||||||||||||||||||||||.||.|||.||  |||||. ||
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 183-451 4.6e-112 368.6 In-house 1-270 (290) alignment 
Range on Protein: 183-451
Range on HMM: 1-270/290.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCQNDYINASFIDGYSSAYRYIATQGPM
||||.||||||| |||...| | .|.  ...   .|..|. ....||.||||.|..|||||||.|.|...|. |.|.||||..|.||. ...|||||||.
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

ANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHG-VPEYATS
 |||||||.||||||  .|||.|| .| |..||.|||||||.  ||.|...|.. ..| .|. |.|..    |.... ..|||..|.|...| |....|.
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
.|......|...|.......||||..|||...|.|..........||.||........|.|.. .|||  
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvq
subfamily_PTPRD_pd Subfamily PTPRD 183-450 8.2e-106 349.9 In-house 4-267 (564) alignment 
Range on Protein: 183-450
Range on HMM: 4-267/564.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHNDlDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCqnDYINASFIDGYSSAYRYIATQGPM
 ||| .. |.||  .||.| .|...|  ...  ...... .  . ||. ||. |.. || .|..|.... .||.  ||||||||||| .   |||||||.
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPl

ANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLiLLGSDQPPLMITQYHFTSWPDHGVPEYATSI
|.|. ||||..|... ..|||.|.| | |..|||.|||....  || ..||| ... | ||..|...|    ...   ...|.||||||||||||.|||.
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatsl

LQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
|.. |....  .|..||..|||||||||||||..||. |.....|. .|| ......|.|| .||||.
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqte
0051299 (Phosphotyrosine protein) phosphatases II 183-450 1.5e-95 315.3 In-house 4-272 (288) alignment 
Range on Protein: 183-450
Range on HMM: 4-272/288.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPM
 |.| .. ..|   .||.   .....  . . | ........ ..|.. ||....| ||..|..|..|...||  .||||||.|||| .  ..||||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgveg..sdYinAsyidgynlkrkfIatqgPl

ANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLG---SDQPPLMITQYHFTSWPDHGVPEYA
 ||. ||||..|... .||||.|.|.| ||.||.||||...|..||...|||.. .||.|||||.|..  |.    |. ....|..|.|.|||||||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
...|.| |.... .....||..||||||||||||| |.|. |.| |||||.|. ....|.|.||..|||| 
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 183-452 2.6e-95 314.1 In-house 3-271 (305) alignment 
Range on Protein: 183-452
Range on HMM: 3-271/305.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHNDldKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPM
 | . .. ... . ....|... .|| .. ..  .. . .  ...||  ||.... ..||.||||.. .|..  ..||||||..|||..  .||..|||.
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPl

ANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSV--YYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYAT
 ||..||||||..||...|||.|.|.|||..||.||||.| .    .|.|.|.| ...  .||. |.|..    .|.    ..||..|.|||||||..||
kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

SILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
|.|.. .|.....|  || |.||||||||||||.|.|.|. |....||. .|.  .....|..|| |||| ..
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldq
0050432 (Phosphotyrosine protein) phosphatases II 198-450 4e-93 307.4 In-house 38-285 (308) alignment 
Range on Protein: 198-450
Range on HMM: 38-285/308.0
ANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILkplpsheGCQNDYINASFIDGY--SSAYRYIATQGPMANTLVDFWRLIWQ
|..   .....  . .  . .|....  ..||..||....| || .|..|       .  .||||||..|||   .  ..||||||. ||. ||||..|.
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

EKPHVIVMVTNLMEGGRNKCHQYWPDS---DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
.. .||||.|.|.| ||.||.||||..   .|..||.|.|||.. .||.|||||.|.|  ||...  ...|..|.|.|||||||......|.| ..... 
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrks

YkpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.   .||..||||||||||||| |.|. |.| |||||.|. ......|.||..|||| 
l..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0040438 (Phosphotyrosine protein) phosphatases II 187-450 4.6e-92 304.0 In-house 3-262 (317) alignment 
Range on Protein: 187-450
Range on HMM: 3-262/317.0
GKFGEFVADGHANNDEEFMKQYALFHNDLDKhEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMANTL
 .. ... | ....   .....  . .     .....  ..||..||....| ||..|..|.||.....  .||||||..||..   ..||||||. ||.
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdld..sdYInAsyvdgpnlkrkfIatqgPlpntv

VDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFH
 ||||..|... .||||.|.|.| ||.||.||||. ....||.|.|||.. ..|...|.|.|..  |  |......|..|.|.|||||||.. ...|.| 
edFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfl

RRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
..... ... .||.|||||||||||||| |... |.| |||||.|. ......|.||. .||| 
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp
subfamily_PTPRB_pd Subfamily PTPRB 182-452 5.6e-91 299.6 In-house 5-273 (293) alignment 
Range on Protein: 182-452
Range on HMM: 5-273/293.0
NLIPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGP
. | . || |.|.. .|..| .|...|  ...   ....... ...|.  ||..|.| || .|. |..| ...  ..|||||..|.||.|   .||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdes..gsDYinanyipgynsprefiatqGP

MANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDS-DSVYYGPFKVTLIDKQVLPDYTVRELQLILlgsDQPPLMITQYHFTSWPDHGVPEYAT
. .|. ||||..|..| ..|||.|.|.|.|. ||..|||.  ..|.||  ||||. ...| |...|||..     ..    ..|||||||||||||| ..
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektk

SILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
..|.| |.....   . .|.|..|||||||||||||.|.|. ||. |.|  .||..|. ..|..|...||| ..
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq
0046845 (Phosphotyrosine protein) phosphatases II 205-450 7.7e-90 296.4 In-house 3-260 (284) alignment 
Range on Protein: 205-450
Range on HMM: 3-260/284.0
MKQYALFHNDLDK--HEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHeGCQNDYINASFIDGY-----SSAYRYIATQGPMANTLVDFWRLIWQEK
....    .   |  ....... ..|. .||....|.||..|..||.|...    .||||||..|||      .  ..||||||. ||. ||||..|...
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

PHVIVMVTNLMEGGRNKCHQYWPDSD-SVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--
 .||||.|.|.| ||.||.||||... ...||.|.|||....| .|||||.|.|  || .......|..|.|||||||||......|.| | ... ..  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---GIDIISIINRMRQQRMFMVQTR
|..||..||||||||||||| |.|. |.| ||||   |.|. ....|.|.||..|||| 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0036941 (Phosphotyrosine protein) phosphatases II 202-450 8.5e-89 293.0 In-house 13-263 (297) alignment 
Range on Protein: 202-450
Range on HMM: 13-263/297.0
EEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILkplpshEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVI
  ..|..  . . |   ..... ...|...||....| ||..|..|      ..  .||||||..|||.  ...||||||. ||. ||||..|... .||
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMVTNLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQV--LPDYTVRELQLILLGSDqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--P
||.|.|.| ||.||.||||.   .|..||.|.|||.. .|  |.|||.|.|..  .|.. .....|..|.|.||||||||...|.|.| ..... .|  |
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

TKGPMLVHCSAGVGRTGTFMAIDMGLQQAE---KEGGIDIISIINRMRQQRMFMVQTR
 .||.||||||||||.||| |.|. ||| |   ||||.|| .... .|.||...||| 
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
0047943 (Phosphotyrosine protein) phosphatases II 197-450 1.5e-88 292.1 In-house 7-258 (273) alignment 
Range on Protein: 197-450
Range on HMM: 7-258/273.0
HANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILkplpshEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQE
....   ..... |. .  . ....... ..|| .||....| ||..|..|      ..  .||||||..||| .  ..||||||. ||. ||||..|..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

KPHVIVMVTNLMEGGRNKCHQYWPDSD---SVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
. .||||.|.|.| ||.||.||||..    |..||.|.|||.. .. .|||||.|.|  ||... ....|..|.|.|||||||.. .|.|.| . ... .
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkal

KP--TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.    .||..||||||||||||| |.|. |.| |||||.|. ......|.||. |||| 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp
0043336 (Phosphotyrosine protein) phosphatases II 185-450 6.3e-87 286.8 In-house 3-263 (278) alignment 
Range on Protein: 185-450
Range on HMM: 3-263/278.0
PVGKFGEFVADGHANNDEEFMKQYALFHNDLDkHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMAN
.| .. ..... ..|.   .....  ...     ...|. ...||..||....| || .|..|..|.....  .||||||..|||.   ..||||||. .
svkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpe

TLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPdSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQ
|. ||||..|... ..|||.|.|.| ||.||.|||| ..|..||.|.|||.. ..|.||||| | .  ||.... ...|.||...||||||||  ...|.
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllld

FHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
| ..... ... .||.||||||||||||||.|... |.|.|||||.|. ......|.||. .||| 
flkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp
0045450 (Phosphotyrosine protein) phosphatases II 185-450 8.7e-85 280.4 In-house 10-290 (307) alignment 
Range on Protein: 185-450
Range on HMM: 10-290/307.0
PVGKFGEFVADGHANNDEEFMKQYALFHNDLD--KHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHeGCQNDYINASFI--------DGYSSAYR
.. |.  .|.  .... . . |..  . .  .   .|..|. ...||..||....| ||..|..|..|...    .||||||..        ||| .  .
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrk

YIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSV-YYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDH
.||||||. .|. ||||..|... .||||.|.|.| ||.||.|||||.... .||.|.|||.....|..|||| | .  |. .......|..|.|.||||
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

GVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQRMFMVQTR
|||..  ..|.| ..... .   | .||.||||||||||||||.|... |.| ||||    .|. ......|.||. .||. 
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp
0039614 (Phosphotyrosine protein) phosphatases II 197-450 1e-84 279.8 In-house 27-275 (297) alignment 
Range on Protein: 197-450
Range on HMM: 27-275/297.0
HANNDEEFMKQYALFHNDLDKheMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHeGCQNDYINASFIDGYSS-AYRYIATQGPMANTLVDFWRLIWQ
.||.   .....    .  .   ..|. ...||..||....| ||..|..|||....    .||||||..|||.    ..||||||. .|. ||||..|.
kansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

EKPHVIVMVTNLMEGGRnKCHQYWPDSDSvYYGPFKVTLIDKQVLPDYTVRELQLILlgsDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-
.. .||||.|.|.| || ||.||||.. . .||.|.|||.. ..|..||||.| .     .......|....|.|||||||......|.| . ... .. 
qgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealae

-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
 | .||.|||||||||||||| |... |.| |||||.|. ......|.||. .||| 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 184-451 7e-84 276.6 In-house 2-267 (318) alignment 
Range on Protein: 184-451
Range on HMM: 2-267/318.0
IPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMA
|.| .. . |.  ... . .. ..|  .. . ..   . |... ||  ||. |.| ||. |. |..| ..||   |||||..|||| .   |||.|.|..
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeeg..sDyinanyidGyrrkkayiaaqaPlp

NTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQpPLMITQYHFTSWPDHGVPEYATSIL
.|. ||||..|. .  ||||.|...| |..|.|.|||...|  ||  .|.| ..  | ||..||...   ....   .. |||.|||||.|||| ..|.|
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeee.srqvrqyhytsWpdegvpesgasll

QFHRRIKNEY-KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
.. |....   |...||..|||||||||||.|.|.|. |.....|. .|.  .....|.||  ||||. 
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqted
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 192-452 1.7e-83 275.0 In-house 11-267 (288) alignment 
Range on Protein: 192-452
Range on HMM: 11-267/288.0
FVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWR
 ||  .|.| ..| ..|    .   ... |..   .|.. ||.||.| || .|. || |.  .  ..||||||.|||. .  .|||||||.|.|. |||.
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyidgekkkkkyiatqgPladtvndfWe

LIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDS-VYYGPFKVTLIDKQVLPDYTVRELQLIllgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK
|....| . |||.|.|.|||..||..||||.|  . || ..|||.... | |...|.| |     ..  | ||||....|||||||| .. .|.. | .|
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvk

NEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
.  .   ||..|||||||||||||.|.|. ... |.|  ||........|.||...|||  .
vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkq
subfamily_PTPRG_pd Subfamily PTPRG 184-450 7.3e-83 273.7 In-house 1-273 (563) alignment 
Range on Protein: 184-450
Range on HMM: 1-273/563.0
IPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKH--EMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCQnDYINASFIDGYSSAYRYIATQGP
.|| .| . ||. ||..|  | ...   ..   ..  ... |  ..||  ||  |.. ||  |. |.||| ...   |||||..||||  .  .||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

MANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLIL---L-GSD-QPPLMITQYHFTSWPDHGVP
...|. ||||.||... ..|||.||| | ||.||..|||  .|. || ..||||...||  ||||.|..       ... .  ....|||.|.|||||||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

EYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
|...  |.| .. .   | . ||..||||||||||||....|  |.| ..|  ...  .. ..| || |.|||.
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqte
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 184-451 1.8e-82 271.9 In-house 5-270 (319) alignment 
Range on Protein: 184-451
Range on HMM: 5-270/319.0
IPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKhEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMA
|.| .. | .   ... .  . |.. |...  .. ... .  ..||. ||..|.| ||  |..|..|.  ||   |||||||||||    ..||||.|..
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgveg..sdyinasfidgyqerekfiatqaPle

NTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSIL
||. ||||..|.|. ...||.|.| | .. |...|||. . . || . ||| ... | || .|.|.|  . |.    .......|.||||.|||.|||.|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

QFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
.. .||..  . ...||. |||||||||||||...|. |.. ..|| .|. |...|.| || .|||. .
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpe
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 199-449 4.5e-82 270.1 In-house 12-278 (301) alignment 
Range on Protein: 199-449
Range on HMM: 12-278/301.0
NNDEEFMKQYALFHNDLDKhEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKP
.. ..| .||   ..  || ..|...|..||.||||.|. ||||||||||| |. . ||..|||||.|||||.. ..||.|||| .||||||||||||||
khsnkfeeqykelkegedk.sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

HVIVMVTNLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQVLPDYTVRELQLILL--------------GSDQPPLMITQYHFTSWPDHGV-PEYATS
  ||||||| || ..||.||||.|  .| ..|||.|||...||.||...|.|....                ||. .  ..|.. |.||..|| .|..| 
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQT
.   .  |. . |. .||..||||..|.|.|.......|| |.  || .|.. .....|.... .|.|
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtT
DSPc_SM00195 206-450 4.7e-80 264.1 In-house 4-248 (263) alignment 
Range on Protein: 206-450
Range on HMM: 4-248/263.0
KQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVT
...    .   ..|.| .  .|||  ||..|.|.||..|..||. ...   ..|||||..|.|...  .|||||||. .|. ||||..|.|| ..|||.|
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQVLP-DYTVRELQLILLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLV
. .| |..||..|||..  ..  .| ..|.|....  . ....|.|.|   |  . .  .|||....|||||||. ..|.|.. | .|.... ..||..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
||||||||||||..||. |.. |.|  .|| .|....|.||. ||||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
PTPc_SM00194 206-450 4.7e-80 264.1 In-house 4-248 (263) alignment 
Range on Protein: 206-450
Range on HMM: 4-248/263.0
KQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVT
...    .   ..|.| .  .|||  ||..|.|.||..|..||. ...   ..|||||..|.|...  .|||||||. .|. ||||..|.|| ..|||.|
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQVLP-DYTVRELQLILLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLV
. .| |..||..|||..  ..  .| ..|.|....  . ....|.|.|   |  . .  .|||....|||||||. ..|.|.. | .|.... ..||..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
||||||||||||..||. |.. |.|  .|| .|....|.||. ||||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl
0040439 (Phosphotyrosine protein) phosphatases II 219-450 5.2e-80 263.9 In-house 2-232 (249) alignment 
Range on Protein: 219-450
Range on HMM: 2-232/249.0
EMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSheGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQY
|....  ..||..||....| || .|..|..||.  .  .||||||.|||| .  |.||||||. .|. ||||..|... .||||.|.|.| ||.||.||
eysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMA
||...|..|| |.|||.. .|..|||||.|.|  |  |...........|.|||||||..  ..|.| ..... ..  |..||.|||||||||||||| |
wplggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

IDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
... |.| |||.|.|. .... .|.||. .||. 
aylmleqlekelgvdleeavkllrsqRpgavqnp
0045098 (Phosphotyrosine protein) phosphatases II 204-450 1.2e-79 262.9 In-house 9-258 (278) alignment 
Range on Protein: 204-450
Range on HMM: 9-258/278.0
FMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIIlkplpshegcqnDYINASFIDGYssAYRYIATQGPMANTLVDFWRLIWQEKPHVIVM
.. ..  ..   .  |.| ..  .|...||....| || .|..            ||||||.||||    ..||||||. .|. ||||..|... .||||
lllefefllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

VTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILL---GSDQPPLMITQYHFTSWPDHGVPEYA--TSILQFHRRIKNEYK----
.|.|.|.||.||.||||...|..||.|.|||.. .||.|||.| | .. |    .| ... .|..|...|||||||..   .|.|.. ..|.. .|    
ltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

---------PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAekEGGIDIISIINRMRQQRMF-MVQTR
         . .||.|||||||||||||. |... |..   |||.|. .... .|.||.. .||. 
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 195-451 6.5e-79 260.0 In-house 8-263 (281) alignment 
Range on Protein: 195-451
Range on HMM: 8-263/281.0
DGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPlpSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIW
. ..|... |...|. ...   ..  | | ...|.  ||..|.  ||  |. ..|  ..|  ..|||||.|..||..  .|||||||. ..||.||...|
qlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtp..neenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvw

QEKPHVIVMVTNLMEGGRNKCHQYWPDSD-SVYYGPFKVTLIDKQVLPDYTVRELQLilLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK-NE
..| ..|||||. .|.|. |||.|||| . .. || ..|. . ..  . |  |...|    .. ..  ..| ..|.|||||||. .. .|.|.. ..  .
eqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlklt

YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMFMVQTRA
 | || |...|||||||||||..|.|  ....|.|   .|.  ... .|..|..|||| .
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvv
Y_phosphatase Protein-tyrosine phosphatase 228-450 8.4e-79 259.7 Pfam-A 1-223 (235) alignment 
Range on Protein: 228-450
Range on HMM: 1-223/235.0
NKPLNRFRNVLVYDDNRIILkplpSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWP--DSDSV
||  ||....|.||..|. |    .... ..|||||....||..  ..||||||. .|. ||||..|||| .||||.|.|.| ||.||.||||  ...|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

YYGPFKVTLI-DKQ-VLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
.|| .||.|  ...    .||.|.|.|   .... . ...|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AEKEGGIDIISIINRMRQQRMFMVQTR
.|.|. .|. .|....|.||. |||. 
leaeeevdvlqivkelRkqRpgmvqsl
Y_phosphatase Protein-tyrosine phosphatase 228-450 8.4e-79 259.7 In-house 1-223 (235) alignment 
Range on Protein: 228-450
Range on HMM: 1-223/235.0
NKPLNRFRNVLVYDDNRIILkplpSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWP--DSDSV
||  ||....|.||..|. |    .... ..|||||....||..  ..||||||. .|. ||||..|||| .||||.|.|.| ||.||.||||  ...|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

YYGPFKVTLI-DKQ-VLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
.|| .||.|  ...    .||.|.|.|   .... . ...|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AEKEGGIDIISIINRMRQQRMFMVQTR
.|.|. .|. .|....|.||. |||. 
leaeeevdvlqivkelRkqRpgmvqsl
0042113 (Phosphotyrosine protein) phosphatases II 221-450 2.2e-78 258.3 In-house 2-229 (245) alignment 
Range on Protein: 221-450
Range on HMM: 2-229/245.0
TISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWP
...  ..||..||....| ||..|..|.| .....  .||||||..|||    ..||||||...|. ||||..|... ..|||.|...| ||.||.||||
svallpenkdknrysdilpydhtrvklspdggdld..sdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

DSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDM
...|..|| |.|||.. ..|.|||||.|..  |  | .......||...|||||||..  ..|.|...... .. . .||.||||||||||||||.|...
lgesltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

GLQQAEKEGGIDIISIINRMRQQRMFMVQTR
 |.|.|||.|... ... ..|.||. .||| 
mleqlekelgvsleeavkelrsqRpgavqtp
subfamily_PTPRA_pd Subfamily PTPRA 183-451 4.2e-76 250.9 In-house 13-282 (330) alignment 
Range on Protein: 183-451
Range on HMM: 13-282/330.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPM
 .|| |. | .    |.. . | ...  .     .  . ..  ..||  ||. |.| || .|.|| ..  .|  . |||||||||||    ..||.||| 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaqGPk

ANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSD---QPPLMITQYHFTSWPDHGVPEYA
..|. ||||.||. | . |||.|.| |  ..||.|||||  .| ||  .|.. |..|| |||||.. .  |.     ... ...|.||||||| |||  .
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

TSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
  .|.. ...|.  . . ||. |||||||||||||...|  |.. . |. .|.  ...|.|.||  ||||  
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtde
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 206-452 7.4e-76 250.2 In-house 34-278 (298) alignment 
Range on Protein: 206-452
Range on HMM: 34-278/298.0
KQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVT
..     ......|.... ...||  ||. ... .|  |..|.   . |  . |||||||...|.    .||||.|. .|..||||....|.  .|||.|
qrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedade..esdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmlt

NLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKG--PMLVH
|| | .. |.|.||||. .  || ..|.|  |..  |..||.|..    ..    .. | |||||||.||||.|||.|.. |...  ..   |  |..|.
nleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivq

CSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
|||||||.|||.|||  |....||  .|.  .....|..|. .|||...
CsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 465-730 1.6e-74 245.8 In-house 19-286 (305) alignment 
Range on Protein: 465-730
Range on HMM: 19-286/305.0
TGQTGYNKQFTVLEQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQP--NYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAI
. ..|...|.  | .  ... .|... |...|....... |..|  ..  | ...  .|||| |||.||..|..|.| .|. .||..||..| .. |. |
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLCQEKENDEEVCYKYWPTEATE-VIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNT
|||.. .|.... |..|||.. || . |||.|..| .|. .  |.|| ..| .. .    . |.|||.| |  .| ..   ..| ......|.|... ..
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
...||||..|||. .|.|    ....|.|.|.|||.|||  | .... ||| .||  ...... .. ..
pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
0037934 (Phosphotyrosine protein) phosphatases II 220-450 9.3e-74 243.3 In-house 2-228 (243) alignment 
Range on Protein: 220-450
Range on HMM: 2-228/243.0
MTISVSQKNKPLNRFRNVLVYDDNRIILkplpshEGcqNDYINASFIDGYSsayRYIATQGPMANTLVD----FWRLIWQEKPHVIVMVTNLMEGGRNKC
..|. .. |.. ||....| ||..|..|      ||  .|||||..|...    |.||||||. .|. |    |||..|... .||||.|.|.| ||.||
fsiallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekc

HQYWPdsDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--------YKPTKGPMLVHCSAG
.||||  ..|.||.|.|||.. ..|.|||||.|.|  |. |........||...|||||||.  ...|.|.. ...         . ...||.|||||||
aqywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTFMAIDMGLQQAekegGIDIISIINRMRQQRMF-MVQTR
||||||. |... |..     |.|. ......|.||.. .|||.
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtp
subfamily_PTPN6_pd Subfamily PTPN6 215-451 2.3e-73 241.9 In-house 41-284 (306) alignment 
Range on Protein: 215-451
Range on HMM: 41-284/306.0
LDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpSHEGCQNDYINASFIDG--YSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGR
 .... . .  ..||  ||..|.| .|..|.|||   ...  ..|||||..|..   .|  .|||||| . .|. ||||..|||. .||||.|. .| |.
kkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgk

NKCHQYWPDSDS-VYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK----GPMLVHCSAG
.|| .||||. .   ||  .|| .... | ||..|||..    ...    . ||||.||||||||.    .|.| . ...... ..    ||..||||||
ekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaG

VGRTGTFMAIDMGLQQAEKEG---GIDIISIINRMRQQRMFMVQTRA
.||||||. ||. |.. ||.|    ||| .... .|.||  .||| .
iGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteq
subfamily_Ptp69D_pd Subfamily Ptp69D 193-449 3e-73 241.6 In-house 13-271 (307) alignment 
Range on Protein: 193-449
Range on HMM: 13-271/307.0
VADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRL
.   . . |. ..| |   ..   ... ..|  . |.  ||. ..  .|..|..||... .|  . |||||||| ||    ..|| |.|. .|. ||||.
lksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveatigDfWRm

IWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQ----PPLMITQYHFTSWPDHGVPEYATSILQFHRR
|.. . ..|||..|| |  |.||..|||. | | ||   |.|....  .||. |||..   . .         ..|||.|.|.|  ||| |...|.. ..
iaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieq

IKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQT
... ||  ..|..|||||||||.|.|.|.|. ||| ..|  .||. ..  .|.|| ..|| 
vrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs
0050432 (Phosphotyrosine protein) phosphatases II 464-734 1.8e-72 239.6 In-house 38-306 (308) alignment 
Range on Protein: 464-734
Range on HMM: 38-306/308.0
ETGQTGYNKQFTVLEQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLkGQQPNYINAVYVDSY--KERKAFIIAESPMFSTVRNFWKMIEDINVTA
 .. ......|  | .|.  . | ..    .||||||.. .|| |. ||.| ..  .|||| ||| |  | ...||.. .|. .|| .||.|. . ||. 
aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVMLCQEKENDEEVCYKYWPTE--ATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrrsG
||||... ||. | |..|||.|   . ...| ....||.|| .| || ||.|..|. .| | ..| ... |.|.  |  .  ...| .||...|..   .
IvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrksl...p

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
.  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||.|||. ...... || ... . 
ggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 225-452 2.5e-72 238.1 In-house 6-230 (250) alignment 
Range on Protein: 225-452
Range on HMM: 6-230/250.0
SQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCqnDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNkCHQYWPDSDS
  .||  ||. ... .|  |..|..  . . .  |||||||..||.    .||||||. .|..||||....||  .|||.||| | ... .|||||   .
kpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

VYYGPFKVTLIDKQVLPDYTVRELQLILlGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQ
  ||  .|.| .|..  |||.|.|.|    . .   .. |.||..||| ||||.||..|.. .... . .   ..|..|.|||||||.|.|.|||  |..
ekyGdvtvsllskeefadytkrklklsk.akkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

AEKEGGIDIISIINRMRQQRMFMVQTRAR
..||  .|.  .|...|..|. .|.....
lkkekvvdvfkvikvlrkdrphavesleq
subfamily_PTPRK_pd Subfamily PTPRK 222-450 9.3e-72 236.5 In-house 37-263 (314) alignment 
Range on Protein: 222-450
Range on HMM: 37-263/314.0
ISVSQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPD
 .  ..|.  ||. ..| ||  |..|...  ..  ..|||||..||.|  .  .|.||||. .|. |||||...|.   |||.|.|.| || || .|||.
aakkdenreknrsgdilaydrsrvfliti..dgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

SDSVyYGPFKVTLIDKQVLPDYTVRELQLILL-GSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMG
  .| ||..||.|.. ..| .. || ...  |  . .   .. |..|..||||.|| .||..|.. ||.|.  ....|...|||||| ||||||.|||. 
dtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv

LQQAEKEGGIDIISIINRMRQQRMFMVQTR
|. .|.|| .|.  ..  .|.... ||.| 
ldmieregvvdvfnavktlrsrkvnmvete
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 184-451 9.6e-72 236.6 In-house 6-266 (315) alignment 
Range on Protein: 184-451
Range on HMM: 6-266/315.0
IPVGKFGEFVADGHANNDEEFMKQYALFHNDlDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILkPLPSHEgCQNDYINASFIDGYSSAYRYIATQGPMA
||. ..  .||. .|.  . | ..|       . | . ..   .||  ||. |.. ||  |. | ||   .  . ||.||.|||||.   ||||.||| .
ipldqlityvaqkkastkngfkqdyesipgg.qlhpldvakkienkqknryiniiaydksrvql.pllend.phsdyvnanfidGynkkrryiaaqgpnv

NTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSdSVYYGPFKVTLIDKQVLPDYTVRELQLIlLGSDqpPLMITQYHFTSWPDHGVPEYATSIL
... |||||...|.   |||.|||.|| ..|. .||||   | ||.. ||.....|  .|||| |  .  |..     . |.|.||||| |||.|.....
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvv.fgdn..irevvqlhytswpdmgvpkytiplm

QFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
...|..|   . . |...|||||||||||||...|  |.||| |  ||.  .|...||.|. |||. .
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvae
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 453-731 4.6e-71 234.5 In-house 12-294 (298) alignment 
Range on Protein: 453-731
Range on HMM: 12-294/298.0
SMIGKLSEQDPETGQTGYNKQFTVLEQVTQKPDEVTHNIA--SQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFST
 .. ||.. ..... |||...|  |..|... .| ....|  ..||.||| .. .. |  ||||.     .. .||||.....||.|.|||... |. .|
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltet

VRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILM
| .||.|. . ....|||| . .| |.  . ||||.| .|  .|| ...||..| .  .. |......| .  ....|.| . | |  .|. . ....| 
vedFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvld

ILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFM
.|......|...||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| |||. |.|.|. .|||| 
llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
0046845 (Phosphotyrosine protein) phosphatases II 472-735 2.8e-70 232.2 In-house 4-282 (284) alignment 
Range on Protein: 472-735
Range on HMM: 4-282/284.0
KQFTVLEQVTQKPD-EVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ-----PNYINAVYVDSY-----KERKAFIIAESPMFSTVRNFWKMIEDINVT
..|  | ..| |.  .... .. .|..|||....|| |. ||.||  .      .|||| ||| |     . .|.||..  |. .|| .||.|. . ||.
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

AIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRR-SG
 ||||... ||. | |..|||.| . ...|.....||.|| .| || ||.|..|.  .|  ..| ....|.|  .|  .  . .| .|..... ... .|
vIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYSN
.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||.|||. ..|... || ... . .
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
0036941 (Phosphotyrosine protein) phosphatases II 467-732 9.2e-70 230.6 In-house 12-282 (297) alignment 
Range on Protein: 467-732
Range on HMM: 12-282/297.0
QTGYNKQFTVLEQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLC
 ... |.|  | .. ... . .. .  .|..|||.. .|| |. ||.|...  .|||| ||| |.  ..||... |. .|| .||.|. . ||| ||||.
lalllkefeellpl.lllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

QEKENDEEVCYKYWPTE-ATEVIFGEYSIKLLNEEL--YDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS-GNTS
.. |.. | |..|||.|   .. .|.....||..|   .| || ||.|.... ..|  ..| ....|||  .|  .... .| ..|...| .. . ... 
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

IVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFML
..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||.|||. . |... .| ....
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0051299 (Phosphotyrosine protein) phosphatases II 465-727 9.3e-70 230.7 In-house 20-286 (288) alignment 
Range on Protein: 465-727
Range on HMM: 20-286/288.0
TGQTGYNKQFTVLEQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVT
.|.||. ..|  | ... .  .... .  .|..|||.. .|| |. ||.|.        .|||| |.| |.  ..||... |. .|| .||.|. . ||.
ngltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

AIVMLCQEKENDEEVCYKYWPTeATEVIFGEYSIKLLNEELYDLYTERTIEIKNKM---KGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRr
 ||||... |.. | |..|||.  . ...|.....||.|| .| || ||.|..|.    ..|  ..| ... |.|  .|  .  ...| .|....| .. 
vIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.

SGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
||.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||.|||. ..|..  ||
sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 462-727 1.6e-69 229.7 In-house 6-272 (273) alignment 
Range on Protein: 462-727
Range on HMM: 6-272/273.0
DPETGQTGYNKQFTVLEQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTA
.. .| |.. ..|  | ...  . . .. .  .||||||.. .|| |. ||.|...  .|||| ||| |.  ..||... |. .|| .||.|. . ||. 
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLCQEKENDEEVCYKYWPTEAT--EVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGsRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS-
||||... |.. | |..|||.|    ....|.....||.|| .| || ||.|..|.  |   ..| ... |||  .|  .  . .| ..|...|... . 
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealp

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
.|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||.|||. . |..  ||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN12_pd Subfamily PTPN12 218-451 2e-69 228.7 In-house 30-264 (290) alignment 
Range on Protein: 218-451
Range on HMM: 30-264/290.0
HEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQ
.. . . ...|.  ||....| || .|. |.   ..|  ..|||||.|| | ..  .|||.|||...|| ||||.||. . ...||. ...| |..||..
ysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPDS--DSVYYGPFKVTLIDKQVLP-DYTVRELQLILLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTF
|||..  ... .|.|.|||.... .  |...| |..   .  .   ...|.|.|.|||||||. |.|.|.. . ...  .  . |..|||||||||||| 
YWpeegeeelefgefevtleeekavdddflirtLkveaqkesr...kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGti

MAIDMGL---QQAEKEGGIDIISIINRMRQQRMFMVQTRA
.|||.     ..   .  .|. ... ..|.||  .|||. 
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtke
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 184-450 1.9e-68 225.7 In-house 3-263 (315) alignment 
Range on Protein: 184-450
Range on HMM: 3-263/315.0
IPVGKFGEFVADghaNNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSSAYRYIATQGPMA
||| .|  ||     |    .. .      | | .. ...  . | . ||..|.| .| .|..|. .   .  ..||||||.| .. .   |||.|||  
ipvaqfpafvnk...nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevi..ddsPdsdyinasyiksvdddkayiasqgPlk

NTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPD--SDSVYYGPFKVTLIDKQVLPDYTVRELqlILLGSDQpPLMITQYHFTSWPDHGVPEYATS
 .. ||||...|||.  |||||.. || . || |||||  .||| .| .||.|.. .   | ..|.|  ..  |..    .||..|| |||.||.. ..|
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrksee.srtvtqfqftewPdkGvdkqtss

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.|.. . .| . .. . ..|||||||||||| ...||  ..|....  .|.  ... .|..|...|||.
llklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqte
subfamily_PTPN9_pd Subfamily PTPN9 193-450 2.4e-68 225.3 In-house 7-276 (297) alignment 
Range on Protein: 193-450
Range on HMM: 7-276/297.0
VADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRL
||  .... .  .|.||  .|   . ... | .. |   ||. .|| ||. |. |. .. .|  . |||||.|.|||     .||||||. .|  ||||.
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfWrm

IWQEKPHVIVMVTNLMEGGRNKCHQYWP--DSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIK
.|...  ||||.| ..| || || ||||  . .|  .| ..|. .. ..  ||.|| |..     ..    .| . |.||||.|||. |.|.|.. . ..
vWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktees.rkvthfqflsWPdyGvPssaaslldvlekvr

N-------------EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.             ...|.. |..||||||.||||||...|. |.. |..| .|..  ....|.|| |..|| 
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtp
subfamily_PTPN3_pd Subfamily PTPN3 204-451 1.7e-67 222.3 In-house 17-262 (280) alignment 
Range on Protein: 204-451
Range on HMM: 17-262/280.0
FMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFID----GYSSAYRYIATQGPMANTLVDFWRLIWQEKPH
 ..|.  ..    . .....   .| . ||.|..| ||. |..||        ..|||||....    . .   ||||||||.|.|  |||...|..| .
vlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss

VIVMVTNLMEGGRNKCHQYWPDS-DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKG
.|||.|.|.| || |||||||.. |.. || |.|..  ..    | .||| |    . .   .|.|  ...|||||||. ....|.| .|...  . .. 
livmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdket.keerkilqlqylaWpdhgvPddsadflefvervrklrsgkee

PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
|..||||||.|||| ...... |.  |..  . .. |. .||.||. .||| .
PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtas
0040438 (Phosphotyrosine protein) phosphatases II 480-730 3.2e-67 222.4 In-house 28-279 (317) alignment 
Range on Protein: 480-730
Range on HMM: 28-279/317.0
VTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEV
 ..|.|. .. .  .||||||.. .|| |. ||.|.  .     .|||| ||| ......||.. .|. .|| .||.|. . .|| ||||....|.. | 
lslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrek

CYKYWPTeATEVIFGEYSIKLLNEELYDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrSGNTSIVVHCSDTVGRSA
|..|||.  ... .|.....||.|| .. .| ||.|.... ...  ..| ... |||   |    .. .| .||.... .. .... ..||||. |||..
caqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
.|.|| . .. ...|| .||....|  | |.||.||| |||. . .... ||  .
tfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 215-450 5.7e-67 221.3 In-house 48-277 (319) alignment 
Range on Protein: 215-450
Range on HMM: 48-277/319.0
LDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTnlmeggRNK
 .  ..| .  ..||  ||. |.| .| |.. |..|   |.   |||||||..|| .  .|||.|||. ||| ||||.||. .   ||..|      ..|
vnladqtfanldqnkdknriinilafdknvvklerliGeef..sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdk

CHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTG
| ||||    . .. ||| .   .   .|.||...|   |  .    |||.||  |||.|||.|.. .... ....     .  . ...|||||||||||
csqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtG

TFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.....|. |.. ..|  .|.  ... .||||  .||  
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl
0045450 (Phosphotyrosine protein) phosphatases II 458-727 8.3e-67 221.4 In-house 17-304 (307) alignment 
Range on Protein: 458-727
Range on HMM: 17-304/307.0
LSEQDPETGQTGYNKQFTVLEQVTQK-PDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG-----QQPNYINAVYV--------DSYKERKAFIIAESPM
|  ... .. ||. |.|  | .|| . ..| ..    .||||||.. .|| |..||.|.      .  .|||| ||        |.|.  ..||.. .|.
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl

FSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQA
 .|| .||.|. . .||.||||....|.. | |..|||.| .|. .|.. ..||.|| .| || ||.|.... . |  ..| ... |||   |  .  . 
petvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfee

ILMILEEMNKTQRRS-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
.| ..||..| .... ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||. |||. . |... .|
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 220-450 2.4e-66 218.9 In-house 35-262 (515) alignment 
Range on Protein: 220-450
Range on HMM: 35-262/515.0
MTISVSQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYW
 |..  . | . ||..|.| || .|..|. .  ..  ..||.|||.| .. .   |||.|||   .. |||||..||..  |.|||.| || . || .||
qtvaqeeinfkknryknilPydsvrvklevi..ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyW

PD--SDSVYYGPFKVTLIDKQVLPDYTVRELQLIlLGSDqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAI
||  .||| .| .|| |.  .   . . |.|...  |.|     .||.||| |||.|||. ..|.|.. . .| .    . |...|||||||||| ...|
PdkpgdsvkfGsikvelvsleactggikrkltvl.kgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisi

DMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
|  . .|..   .|.  ... .||.|...|||.
dsvvahakttrmvdvfnfvtnirqkrpylvqtq
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 216-451 4.3e-66 218.3 In-house 13-242 (284) alignment 
Range on Protein: 216-451
Range on HMM: 13-242/284.0
DKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTnlmeggRNKC
.  ..| .  ..||  ||. ..| .| |.. |..|   |.   |||||||| || .  .|||||||. ||| ||||.||. .   ||..|      ..||
ngtdqtfanldqnkdknrighilafdknvvklerliGeef..sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkc

HQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGT
 ||||    . .. ||| .   .   .|.||...|   |  .    |.|.||  |||.|||.|.. .... ....     .  . ...|||||||||||.
sqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgv

FMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
....|. |.. ..|  .|.  ... .||||  .||  .
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv
0039614 (Phosphotyrosine protein) phosphatases II 464-729 5.7e-66 218.3 In-house 28-291 (297) alignment 
Range on Protein: 464-729
Range on HMM: 28-291/297.0
ETGQTGYNKQFTVLEQVTQkpDeVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ-----PNYINAVYVDSYKE-RKAFIIAESPMFSTVRNFWKMIEDI
 .. |.. ..|  | ...   |  ..    .||||||.. .|| |..||.||.        .|||| ||| |.   ..||..  |. .|| .||.|. . 
ansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweq

NVTAIVMLCQEKENDEeVCYKYWPTEATevIFGEYSIKLLNEELYDLYTERTIEIKNkmkGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRR
.||.||||....|..   |..|||.| .   .|.....||..| .| || ||.|..|   .|  ..| ..| |||  .|   ... .| .||.... ...
gvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealae

S-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDS
. ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| .||. ...... .|  
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 207-450 1.7e-65 215.9 In-house 10-254 (274) alignment 
Range on Protein: 207-450
Range on HMM: 10-254/274.0
QYALFHNDLDKHEMTISVSQKNkplNRFRNVLVYDDNRIILKPLPSHEgCQNDYINASFIDGYSSAY-RYIATQGPMANTLVDFWRLIWQEKPHVIVMVT
..     . |..|.... ||.    ||....|  .  |..|..  |..  . .|||| .| ||.     |.|||||..||. ||||.|.||. .||||.|
eflelPlnfdqeeldvfgsqtk...nryktilPnensrvllesessed.edssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmlt

NLMEGGRNKCHQYWPDSDSV----YYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPplmITQYHFTSWPDHGVPEYATSILQFHRRIKNE---YKPTKG
.| |  ..||..|.||. ..     || ....  ..    ||.||.| |  | . .    .. | .|.|||| .|. |...|.. . ....    .   .
klkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenakla

PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
|..||||||.|||| |.||.....| ..|. .|...|.  .|..|  ||||.
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 227-452 2.6e-65 214.9 In-house 7-229 (239) alignment 
Range on Protein: 227-452
Range on HMM: 7-229/239.0
KNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYS-SAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSV
 ||  ||. |.. || .|..|. |      ..||||||..  |  |   |||||| .. .  ||||..|||.  ||||.| |.|| ..||||||||| | 
vnkaknryanivtydhsrvvleklsnd..phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

YyGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE
|   ..|||   .|. || .| . .  .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.
y.cnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

KEGGIDIISIINRMRQQRMFMVQTRAR
|.  .||.  .. .|..| .||||  .
kqktvdifnyvkairedrphmvqtseq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 227-452 2.7e-65 214.9 In-house 6-228 (239) alignment 
Range on Protein: 227-452
Range on HMM: 6-228/239.0
KNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYS-SAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSV
 ||  ||. |.. || .|..|. |      ..||||||..  |  |   |||||| .. .  ||||..|||.  ||||.| |.|| ..||||||||| | 
vnkaknryanivtydhsrvvleklsnd..phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

YyGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE
|   ..|||   .|. || .| . .  .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.
y.cnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

KEGGIDIISIINRMRQQRMFMVQTRAR
|.  .||.  .. .|..| .||||  .
kqktvdifnyvkairedrphmvqtseq
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 227-452 7e-65 213.6 In-house 2-227 (237) alignment 
Range on Protein: 227-452
Range on HMM: 2-227/237.0
KNKPLNRFRNVLVYDDNRIILKPlpshEGCQNDYINASFIDGYSSA-YRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDS-
.||  ||. |. .|| .|..||      |.. |||||....|.  .  .|||.|||. ..  |||...||||  ||||.| |.|| . |||.|||..|  
enkiknrygnivaydhsrvvlkg....agsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

VYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQ
  || . |.|  |. . ||||| | |   .. .   .| ||.||||||.|||......|.| ..| |. .  .  || ..|||||||||| |. ||  |.
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QAEKEGGIDIISIINRMRQQRMFMVQTRAR
||...  .||   .  . ..| ...||. .
qakekkvvdiynyvysieedrpyiiqtkdq
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 212-454 2.1e-64 212.1 In-house 17-256 (283) alignment 
Range on Protein: 212-454
Range on HMM: 17-256/283.0
HNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPShegcqnDYINASFID---GYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLM
.  . . . .|.....||. ||.......| .|. ||...       |||||.||     |    .||..|.|. .| ||||.....||   |||.|.|.
rlsvpdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklq

EGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGV
|. | || ||||   |. ||.| ||| .      ....|| |   .| .  |... | .  | . |      |...| . | .  .  |||..||||.|.
edlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgi

GRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRARSM
|||..|.|.   ...|  |  .|. .... ||.||| .|||. . .
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyk
subfamily_PTPRD_pd Subfamily PTPRD 469-730 2.2e-64 213.1 In-house 24-284 (564) alignment 
Range on Protein: 469-730
Range on HMM: 24-284/564.0
GYNKQFTVLEQVtqKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVM
  ....  .|.   .  ....  ...|| |||  . .. |. ||||.     .. .|||| ..|.|..|||.| .  |. .|...||.|. . |.. |||
kfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVm

LCQEKENDEEVCYKYWPTEAtEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIV
| . .|.... | ||||..  .  .||. ..| .|| .  |. ||...|.| .  | ..| |.. | |  .|  .  ...| ......... ....  ||
ltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkksses.reVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
||||  |||. .|..    ... |.|...|..|..|  | |..  ||| |||  |.|... .|...
VhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
DSPc_SM00195 471-726 1.1e-63 210.4 In-house 3-261 (263) alignment 
Range on Protein: 471-726
Range on HMM: 3-261/263.0
NKQFTVLEQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLC
...|. ||. |..  |.|... ..||.|||....|| |. || || ..     .|||| |.. ....|..|..  |. |||. ||.|. . .|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QEKENDEEVCYKYWPTEA-TEVIFGEYSIKLLNEELYD-LYTERTIEIKNKMKgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSgNTSIV
.|.||..| |..||| |. ..  ||..|.|| ..| ..  .. ||.|.... |    .|| |||...|. .|    .. .| .|....|....| .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
||||. |||...|... . ..|...|  .|.|...|. | |.||.||| |||. | |..  |
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 471-726 1.1e-63 210.4 In-house 3-261 (263) alignment 
Range on Protein: 471-726
Range on HMM: 3-261/263.0
NKQFTVLEQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLC
...|. ||. |..  |.|... ..||.|||....|| |. || || ..     .|||| |.. ....|..|..  |. |||. ||.|. . .|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QEKENDEEVCYKYWPTEA-TEVIFGEYSIKLLNEELYD-LYTERTIEIKNKMKgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSgNTSIV
.|.||..| |..||| |. ..  ||..|.|| ..| ..  .. ||.|.... |    .|| |||...|. .|    .. .| .|....|....| .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
||||. |||...|... . ..|...|  .|.|...|. | |.||.||| |||. | |..  |
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0043336 (Phosphotyrosine protein) phosphatases II 470-726 1.6e-63 210.1 In-house 22-276 (278) alignment 
Range on Protein: 470-726
Range on HMM: 22-276/278.0
YNKQFTVLEQVTQkpDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVML
. ..|  | ...   |. .. .  .||||||.. .|| |..||.|.  .     .|||| ||| |.  ..||..  |. .|| .||.|. . .|| ||||
lllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmL

CQEKENDEEVCYKYWPteATEVIFGEYSIKLLNEELYDLYTERTIEIKNkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrSGNTSIVV
....|.. . |..|||   . . .|.....||.|| .| || ||.|..| .. |  ..|..|. .||  .|  .  . .| .|..... .. . |. ..|
telvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlV

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
|||. |||...|.|. . ..  ..|| .|.....|  | |.||.||| .||. ..|... |
HCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 467-734 1.8e-63 209.0 In-house 14-300 (301) alignment 
Range on Protein: 467-734
Range on HMM: 14-300/301.0
QTGYNKQFTVLEQVTQKPDEVTHNiaSQNKDKNRSTQFLPPDNHRVVLKGQ------QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVT
......|.. |.....|. .|...  ..||  ||  .  . |..|..|| .      | .|||| |.|.|.|.|.||.|..|| .|...||..| .  ..
snkfeeqykelkegedksctvgls..eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

AIVMLCQEKENDEEVCYKYWPT-EATEVIFGEYSIKLLNEELYDLYTERTIE-----------------IKNKMkggSRHKVVQYQITGWEPNGEVTCHQ
.|||....||. .. |..|||. ||..  ||. ...| ||  |  .. | .                  .|...   | ..|.|.|.| |  .| |  ..
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvrepr

AILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
 .|...... ..|.. |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.| |||  |..... ||     |.
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstya
0045098 (Phosphotyrosine protein) phosphatases II 480-727 2.4e-62 206.1 In-house 18-272 (278) alignment 
Range on Protein: 480-727
Range on HMM: 18-272/278.0
VTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVlkgqqpNYINAVYVDSYkeRKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKY
..  |.|.|...   |.|||| ...|| |. ||.      .|||| |.|.|  .|.||..  |. ||| .||.|. . ..|.||||....|.. | |..|
llgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPTeATEVIFGEYSIKLLNEELYDLYTERTIEIKNK---MKGGSRHKVVQYQITGWEPNGEVTCH--QAILMILEEMNKTQR------------RSGNTS
||     ...|.....||.|| .| || ||... |     ...  ..| ......|. .|  . .  . .| .||.... ..             .... 
wpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

IVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVEQYKGIFEIVQIYL
..||||  |||.....|| . .  .  ||..|.....|  | |.|| .||. |||. ..| .. .|
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 467-723 4.2e-62 204.6 In-house 5-262 (283) alignment 
Range on Protein: 467-723
Range on HMM: 5-262/283.0
QTGYNKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVD---SYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIV
..... .. ||....  . ... . |..|| |||  . .| |..|| || . ..|||||..    |||. | .||| ||.  ||..||||. | ..||||
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLCQEKENDEEVCYKYWPTEATEViFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWepngEVTCHQAILMI---LEEMNKTQRRSGN
|| . .|. .. | .||| . .|  .||. . | .|   . .. . . ....    |   .  ||. .|         |||.     .. .   |..| .
mltklqedlrikCsqyWPkrGsed.yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskk

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
. |||||| ..||.|.|.||...... .|| |.|||.|.|  | |... ||| .||| . |.|
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 493-734 1.3e-61 203.0 In-house 7-249 (250) alignment 
Range on Protein: 493-734
Range on HMM: 7-249/250.0
SQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEvCYKYWPTEATEvI
 |||.||| ..... |. ||||. ..     .||||.....|.||||||.. .|. .|. .||.|. . ....|||| . ||.... . .|||.| .| .
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae.k

FGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHkVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCK
.|.  ..||..| .  || |.. . .. | ..|. |.|.. . |   |     .|.| .|......|...||. ..|.||  ||||  |.|  . ... |
yGdvtvsllskeefadytkrklklskakkaderi.vrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
.| |.|||.|.|  |...|..|.. |||  ..||.. .|||.  |.
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_PTPN23_pd Subfamily PTPN23 198-451 1.9e-61 202.4 In-house 11-267 (288) alignment 
Range on Protein: 198-451
Range on HMM: 11-267/288.0
ANNDEEFMKQYALFHNDLDKHE--MTISVSQKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFIDGYSSA-YRYIATQGPMANTLVDFWRLIW
 ..  .. |........ ||.   ..|......   ||.|..| || ||. |.      | ..|||||||. . |.    .||||.|...|| |||....
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvy

QEKPHVIVMVTNLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
..|  ||||...  | |..|...||| .  ..| .|...||| ... .. .  |.|.|  |..|.   ...  ..||||..|||.   ..|||   ... 
eqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadav.ksvshlqltsWpelGvPasPetllqfldevesa

----YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINRMRQQRMFMVQTRA
     ...| |..|||||||||||.|  .   ... ||. |. ||| ...|.|.|| ||||...
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqeke
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 184-450 2.6e-61 202.4 In-house 10-270 (297) alignment 
Range on Protein: 184-450
Range on HMM: 10-270/297.0
IPVGKFGEFVADghaNNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYSSayRYIATQGPMA
||. .|  .|     | . .....  |       .. | .  . | . .|..|.| || .|..|. . ..   . ||.||||. |.    |.|.|| || 
iplsdfatlvqk...nrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivndd..pdsDyvnasfvkgnkh..rlittqmPmk

NTLVDFWRLIWQEKPHVIVMVTNLMEGGRnKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLIlLGSDQPPLMITQYHFTSWPDHGVPE--YATS
.|. |||.....|.. .|||.... |. . || .||.|. .. .|   |.|   .    .  |||..   |. .   .. ||.|..|||. |..   |.|
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevt.kgkakarrvvkqyqfveWPdkaverkdsass

ILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.|..   ...... ..  |.||||.||||||| ...||  . .|..|  .||  .....||.|...|||.
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtk
Y_phosphatase Protein-tyrosine phosphatase 495-723 6.3e-61 201.1 Pfam-A 1-233 (235) alignment 
Range on Protein: 495-723
Range on HMM: 1-233/235.0
NKDKNRSTQFLPPDNHRVVLKGQQP--NYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWP-TEATEVIFGE
||.|||....|| |. || |||..   .|||| ||..||| |.||... |. ||.  ||.|. . .|..||||....|...| | .||| .| ... .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSIKLL-NEE-LYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
....|  .|.   . || |..|.|.| .   ...| |...|.|. .|  .. ...| ......|.. .. ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
|. .||.|..|. | |.||.||..|||. . ...
eeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 495-723 6.3e-61 201.1 In-house 1-233 (235) alignment 
Range on Protein: 495-723
Range on HMM: 1-233/235.0
NKDKNRSTQFLPPDNHRVVLKGQQP--NYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWP-TEATEVIFGE
||.|||....|| |. || |||..   .|||| ||..||| |.||... |. ||.  ||.|. . .|..||||....|...| | .||| .| ... .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSIKLL-NEE-LYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
....|  .|.   . || |..|.|.| .   ...| |...|.|. .|  .. ...| ......|.. .. ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
|. .||.|..|. | |.||.||..|||. . ...
eeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPN13_pd Subfamily PTPN13 220-451 1e-60 200.3 In-house 29-256 (273) alignment 
Range on Protein: 220-451
Range on HMM: 29-256/273.0
MTISVSQKNKPLNRFRNVLVYDDNRIILKplpsHEGCqndYINASFIDGY--SSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQ
 ... ...||  ||.|||| ||. |..|.     ||    |||||.|        |.|||.|||. .|  |||...|. | .||.|||.  |.|. |||.
cevgkkkenkdknryrnvlPydetrvklg....degg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchr

YWPDSDS---VYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTF
|||.| .   . .. ..|.|.. | | ...||.|... . | .    ... .|..|||||||  |...||| .....  .  .||..||||||.||.||.
ywPesknkklkvsnrlevellkvqkldgfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtl

MAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
..||. |.  |..  .|.  |....|.||  .|||. 
itidvvlglierdkefdvkeivrklreqrqgvvqtkd
subfamily_PTPN1_pd Subfamily PTPN1 204-450 2e-60 199.0 In-house 8-257 (290) alignment 
Range on Protein: 204-450
Range on HMM: 8-257/290.0
FMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVM
. . |   ... ...... .  ..|..|||.|.|  ||  ||.|.        .|||||||...      .|| ||||..||   ||...|..| . .||
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle......radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

VTNLMEGGRNKCHQYWPDSD---SVYYG--PFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPT
. ...| ...||.||||  .   .. .    .||.|| ...   |||| |.|  | ...    |...|.|.||| ||||  .. |.|  ....    .. 
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqet.reilhfhyttwpdfgvpespaaflkflfkvresGslssd

KGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQRMFMVQTR
.|| ..|||||.||.|||. .|  | . ||..    .||   .  .|..|. ..|| 
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta
0042113 (Phosphotyrosine protein) phosphatases II 492-727 4.6e-60 198.4 In-house 6-243 (245) alignment 
Range on Protein: 492-727
Range on HMM: 6-243/245.0
ASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTeATEV
   ||||||....|| |. ||.|.  .     .|||| ||| |.  . ||..  |. .|| .||.|. . ..|.||||..| |.. . |..|||.  ...
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

IFGEYSIKLLNEELYDLYTERTIEIKNkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKC
 .|.....||.|| .| || ||.|..| .. .  ..|..|. ..|. .|. . .. .| .||...| .....|. ..||||. |||...|.|| . ..  
tygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

KTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
..|. .......|  | |.||.||| .||. . |... .|
ekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 218-451 2.1e-59 195.7 In-house 10-251 (270) alignment 
Range on Protein: 218-451
Range on HMM: 10-251/270.0
HEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSheGCQNDYINASFIDGYSSA-YRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCH
.| ..    ..| |||....|     |..|..| .    .  |||| .. |....  .|||..||...|| .|||.||.|| . |||.|.|.| ||.|| 
sesdlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCe

QYWPDSDSV----YYGPFKVTLIDKQVLPDYTVRELQLILLGSDQpPLMitQYHFTSWPDHGVPEYAT------SILQFHRRIKNEYKPT-KG-PMLVHC
.||| .        .|  ||. . ..    | ...|.|   |. .  |.   .....|||||||. .       ..|.  | ...  | . |. |.||||
rYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeer.rlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

SAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
|||||||||..|.|....  |... .|...||...|..|| .||.  
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpe
subfamily_PTPRN_pd Subfamily PTPRN 196-452 2.8e-59 195.2 In-house 23-280 (297) alignment 
Range on Protein: 196-452
Range on HMM: 23-280/297.0
GHANNDEEFMKQY-ALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFI-DGYSSAYRYIATQGPMANTLVDFWRLI
 | .| . . |.. || . . ...  ... ..||   || ..|| ||..|. ||   |.|  ..||||||.| |    |  |||||||.|.|. |||...
dhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasae..ksdyinasaildhdprapayiatqgplastvadfwqmv

WQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVL-PDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
|..   |||..|.| | | ..|..||||  |  |. ..| |. . .   || || . |  | ...    .||.|| |||..|||  | |.|.| |..   
weqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPasaksllefrrkvnks

YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMFMVQTRAR
|.    |..||||.|.||||....||. |..  |    |||.. .. .|.||  .|.|...
yrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdq
0040439 (Phosphotyrosine protein) phosphatases II 487-727 1.8e-58 193.4 In-house 3-246 (249) alignment 
Range on Protein: 487-727
Range on HMM: 3-246/249.0
VTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT
... .   ||||||.. .||.|..||.|.        .|||| |.| |.  ..||..  |. .|| .||.|. . ..|.||||....|.. | |..|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

eATEVIFGEYSIKLLNEELYDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS-GNTSIVVHCSDTVGRSAMFCAAA
  ... .|.....||..| .| || ||.|..|. . |. ..| ..|.|.|   |     . .| ..|...| ...   .. ..||||. |||...|.|| 
.ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
. ..  ..|. .|.....|  | |.||.||. |||. . |... .|
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 186-451 2e-58 193.0 In-house 7-275 (325) alignment 
Range on Protein: 186-451
Range on HMM: 7-275/325.0
VGKFGEFVADGHANNDEEFMKQYALFHNDlDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSSAYRYIATQGPMANT
| .. |.|   .|.... | ... |  .| |   .....  .||  |||.||. .| .|..|. .  ..  . ||||||..  .     ..|.| |...|
vvnlvehvekkkaqdqdgfahefgllpsd.dgiakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltat

LVDFWRLI--WQekpHVIVMVTNLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQVLPDYTVRELQLILlGSDQPPLMITQYHFTSWPDHGVPEYATS
. |.|||.  |.     .|.|.| ...| ..| .|||.   .|. .|...| |.  . . ||  | |..    ..   . . |... ||.| ||... ..
indlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkq.vkkGetrsvkqfqlqswddmGvqkrpat

ILQFHRRIKNEY---KP---TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
.. . . .|.     .    . .|.||||||||||||.|...   |..  .|  .||   ....|..|  ||.|  
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 460-735 3e-58 192.4 In-house 16-288 (318) alignment 
Range on Protein: 460-735
Range on HMM: 16-288/318.0
EqdpeTGQTGYNKQFTVLEQVTQKPDEvTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIE
|    .|.. .....  |....... . .. . . || ||| .  |. |. || |. ..     .|||| |.| |...||.| | .|.  |...||.|. 
e....sGelllseeyerlsrseetvts.lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvW

DINVTAIVMLCQEKENDEEVCYKYWPTEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQ
. | . |||| ||.|.  . . .||| . ..  .|.  ..| .|  .. |. |....... .  || .| ||..| |  .|  .    .| .. . .|.|
eqnsavivmltqeeergkakvhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrteeeesr.qvrqyhytsWpdegvpesgaslldlvrqvskaq

RRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYSN
..||.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  ||| .||. |..... .| |. .. .
qksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_PTPN14_pd Subfamily PTPN14 218-451 4.6e-57 188.3 In-house 39-283 (300) alignment 
Range on Protein: 218-451
Range on HMM: 39-283/300.0
HEMTISVSQKNKPLNRFRNVLVYDDNRIILKPlpSHEGcQNDYINASFIDGY--SSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKC
 ... .  ..|.. |||..|| |.|||. |.|  ..|  ...||||| |     .. . ||..|||. .|. |||...|... ..|||.|.  |.|..|.
allstaklpenaeknrfkdvlPyednrvelsp..tken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeks

HQYWPDS----DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQP-PLMITQYhfTSWPDHGVPEYATSILQFHRRIK------NEY---KPTKGPML
..|.|..    ..| .| ||||   ..  . .. . |.|  | | .   ... ||  | ||||||||  .. |.. ....      |.    | .| |.|
fkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
|||||||||||  .  |. ..  |..  ||| ....|.|.|||..||| |
vhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtla
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 463-730 6.2e-57 188.1 In-house 18-286 (319) alignment 
Range on Protein: 463-730
Range on HMM: 18-286/319.0
PETGQTGYNKQFTVLEQVTQKpdEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDIN
 .||.|. .|.|  |.. ...  ....    .||.||| .. |. |. ||||.     .. .|||| ..|.|.||..|| . .|.  |. .||.|. . .
astgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeee

VTAIVMLCQEKENDEEVCYKYWPTEATEViFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS
.  .|||.. .|. .  . ||||.|  |. .|.. ..|..||  . |  | .....|       .|...| | |  ..  .  ...| .|....|.....
ssivvmltklveklkvklkkywpeenfee.yGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
 .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||. |||| |.|..  .....
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 189-450 1.2e-54 180.4 In-house 7-265 (439) alignment 
Range on Protein: 189-450
Range on HMM: 7-265/439.0
FGEFVADGHANNDEEFMKQYALFHNDLD--KHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYSSAYRYIATQGPMANTL
| | | . . |..| | . .          . . ..   . ... ||...|  .|  |..|. .|     .  |||| .|.||     |||||||  .| 
fqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyyddklyiatqgpkkett

VDFWRLIWQEKPHVIVMVTNLMEGGRnkchqYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILL-GSDQPPLMITQYHFTSWPDHGVPEYATSILQF
 |||||....|   |||.|||.|  .     ||| .. |.||   |    .  ||.|..| ....    . .    . |.|...|||. ||  |. .|.|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

HRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
 | |.  . |   ||..|||||||||||| .|.|. |.|   |  .||  |.. .|.||  |||. 
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqal
subfamily_Ptp69D_pd Subfamily Ptp69D 467-722 1.3e-54 180.4 In-house 21-281 (307) alignment 
Range on Protein: 467-722
Range on HMM: 21-281/307.0
QTGYNKQFTVLEQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAI
. |. | .  ||.  . . . .      |. |||. .  . |..||.||     .. .|||| .. .|||.| ||.|  |. .|. .||.|| . .|| |
dfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLCQEKENDEEVCYKYWPTEaTEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGG----SRHKVVQYQITGWEpNGEV-TCHQAILMILEEMNKTQRR
||| ...| ... | |||| | .|| .|.  .|| .||  . |..|.... .| . .     ..|||||. |||. . .|  . ...| ..|.... .. 
vmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykl

SgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEI
. .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  ||  |||. ..  
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyra
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 465-724 2.9e-54 179.1 In-house 18-276 (288) alignment 
Range on Protein: 465-724
Range on HMM: 18-276/288.0
TGQTGYNKQFTVLEQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVT
...||..... .| .. .| ..||    ..|..|||  . || | .|| ||.    .. .|||| |.|..|..|..| . .|. .|| .||... . ...
rnrtgfseeynsLaal.ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

AIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKnkmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGN
 |||| .  |.... | .|||.. ... .|.  ..|....  . ...|.....   | ... .. ||| ..|  .|    .. .| .|. .. ..  .  
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvan.qadt

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
  |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||..||  |.|.. 
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPRA_pd Subfamily PTPRA 488-726 5.1e-54 178.4 In-house 49-294 (330) alignment 
Range on Protein: 488-726
Range on HMM: 49-294/330.0
THNIA--SQNKDKNRSTQFLPPDNHRVVLK---GQ-QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWP
| ..|   .||.|||  . || |  ||.|    |. . .|||| ..| |||.. || |  |   || .||.|| . . ..|||| . || .|| |..|||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

TEATeVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGG---SRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNtSIVVHCSDTVGRSAMFC
.| . | .|.  ... .|..   || | . .... ..    .   | |.  |.|   |  .  . .| .|....|....|.. .||||||  |||.  |.
deGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfi

AAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
.  . ... |.|...|||...|. | |.|  ||| |||. |..... |
vldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRK_pd Subfamily PTPRK 492-723 5.8e-54 178.0 In-house 40-273 (314) alignment 
Range on Protein: 492-723
Range on HMM: 40-273/314.0
ASQNKDKNRSTQFLPPDNHRVVLK---GQ-QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEaTEV
  .|..||||.. |..|..||.|.   |. . .|||| ..||||  .|||..  |. .||..||... | | ..|||| . .|.    |.|||| . |||
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed.tev

iFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHK-VVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRsGNTSIVVHCSDTVGRSAMFCAAATTINK
 .|.  ..|.. ||   .  |.  ...  .| . .. | |.| .||   .  .  ...| .. ...|.|   ..  ||||||   ||. .|.| .. .. 
.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldm

CKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
 ..|||.|||.. |. | .|.  |.| |||| |....
ieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPRG_pd Subfamily PTPRG 466-724 6.3e-54 178.1 In-house 17-284 (563) alignment 
Range on Protein: 466-724
Range on HMM: 17-284/563.0
GQTGYNKQFT-VLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK---GQQPN--YINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINV
|..|....|  . .....|  ...|  . .|| ||| .. .. |. || |.   |.. .  |||| |.| |.  ||||..  |. .|.  ||.|| . ||
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

TAIVMLCQEKENDEEVCYKYWPTeATEVIFGEYSIKLLNEELYDLYTERTIEIKN-KMKGGSR----HKVVQYQITGWePNGEVTCHQAILMILEEMNKT
. |||. . .|.  . |  |||.  . . .|. ...| .||   |||.||. ||| |.| ...    ..| ||. | | |.  |  |..  .|  . ...
aiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkW.PdhgvPehslpvLifvkkssa

QRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
 ...    ||||||  |||. ....  | ... ..| ...||..||  | |..  ||| |||  ......
ankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall
0037934 (Phosphotyrosine protein) phosphatases II 491-726 4e-53 175.8 In-house 6-241 (243) alignment 
Range on Protein: 491-726
Range on HMM: 6-241/243.0
IASQNKDKNRSTQFLPPDNHRVVLKGqqPNYINAVYVDSYKeRkaFIIAESPMFSTVRN----FWKMIEDINVTAIVMLCQEKENDEEVCYKYWPteaTE
.  .|..||| . .|| |. ||.|.|   .|||| ... .. |  .|.   |. .|| .    ||.|. . ..|.||||....|.. | |..|||    |
llpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...ge

VIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRR-------SGNTSIVVHCSDTVGRSAMFCA
| .|.....||.|| .| || ||....|.  ..  . |..|. ..|  .|  . .. .| .|.|... ...       ...  ..||||  |||.....|
vtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

AATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTVEQYKGIFEIVQIY
| . . ..   | .|.....|  | |.|| .||| .||. . |... .
aylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
0051429 (Phosphotyrosine protein) phosphatases II 258-451 1.4e-52 174.4 In-house 4-212 (272) alignment 
Range on Protein: 258-451
Range on HMM: 4-212/272.0
NDYINASFIDGYssaYR------YIATQGPMANTLVDFWRLiWQEKPHVIVMVTNLMEGGRNKCHQYWP------------DSDSVYYGPFKVTLIDKQV
..||||....||   .|      .....||. .|  ||||| .... ..||......| ||.||..|||            .  .. || . |||. ...
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYAtsILQFHRRIKNeykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID--------
|.||..|||.|.|| | . .......|.|.|||||||. |  .|.. . . .     .||.|||||||..||||. |... |.. ..|  .|        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IISIINRMRQQRMFMVQTRA
.  .....|.||. .||| .
leeaveelraqrpgavqtee
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 229-450 2.1e-52 172.7 In-house 39-263 (287) alignment 
Range on Protein: 229-450
Range on HMM: 39-263/287.0
KPLNRFRNVLVYDDNRIILKPLPSHeGcqNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDS-VYY
   ||. .|| .||.|..|   . . |   ||||| .. .|    ..||.|||.| |. ||||......  .....|  .| .|.||..|||. .  .  
vkknryadvlPiddtrvllsaegel.G..sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

GPFKVTLIDKQVL-PDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-----KPTKGPMLVHCSAGVGRTGTFMAIDMGL
| . |.|.|.... |.|.|| |.|| | . .   .. |... ||||....  | ....|   .|.           ||..||...|.||.|...|. . .
GGysvvlldydikePeygvralrlidletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

QQAEKEGGIDIISIINRMRQQRMFMVQTR
.. |. | .|.  .. |.|..|  .||. 
srledlGrvdvaavvirlreyraalvqav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 184-452 1.3e-50 166.9 In-house 4-224 (392) alignment 
Range on Protein: 184-452
Range on HMM: 4-224/392.0
IPVGKFGEFVADGHAnnDEEFMKQYALFhNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSSAYRYIATQGPMA
||| .|  || . .      |....  .  . | .. |..  . |.. ||..|.| || .|..|. .   .  ..||.|||.|... .   |||.||| |
ipvaqfpafveknrh..salffeefhdl.pgpdiypqtvaqkeinlkknryknilpydsarvklevi..ddipdsdylnasyipsfdnekayiasqgpna

NTLVDFWRLIWQEKPHVIVMVTNLMEGGrnkchqywpdsdsvyygpfkvtlidkqvlpdytvrelqlillgSDQPPLMITQYHFTSWPDHGVPEYATSIL
 .| ||||...||..  |.|||.| ||                                              .    ..|.||| |||..||....|.|
aslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssll

QFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
.| . .| ..     |...||||||||||  ..||  . .|.|   .|.. ..  .|..| .||||. .
kfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeq
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 466-723 1.9e-50 166.6 In-house 22-275 (315) alignment 
Range on Protein: 466-723
Range on HMM: 22-275/315.0
GQTGYNKQFTVLEQVTQKPDEVTHNIasQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTA
 . |.....  .     .| .|...|  .||.|||  . .. |. || |    . .. .|.|| ..| |. .. .| |..|  ..|..||... . ... 
tkngfkqdyesipggqlhpldvakki..enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigk

IVMLCQEKENDEEVCYKYWPTEatEVIFGEYSIKLLNEELYDLYTERTIeikNKMKGGSRHKVVQYQITGWePNGEVTCHQAILMILEEMNKTQRRSGNT
|||| .  |.... . |||| .  .||.|.... . .|| .. || ||.     . |   ..|||...| | |. .|. .   || |    |  . .  .
ivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytsw.pdmgvpkytiplmnlirtvkqhhtnsvg

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
.||||||. |||.  |..  . ... ..| .|||.....  | .. . ||..|||. |....
aivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_PTPN6_pd Subfamily PTPN6 455-728 3.3e-50 165.8 In-house 13-298 (306) alignment 
Range on Protein: 455-728
Range on HMM: 13-298/306.0
IGKLSEQDPETGQTGYNKQFTVLEQV-TQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK-GQQ--PNYINAVYVD--SYKERKAFIIAESPMFSTVR
. .|.... .....|....|  |.|  ..|  . ..    .|| |||    || |. ||.||  .    .|||| |..  . ...|..| ..  . .|| 
vselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvs

NFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMIL
.||.|. . | . |||. .| |  .| |..|||.| ..  .|..|.. ..|.  . |. |.. ...| |... ..|.||. . |  .|  .  .|.|  |
dFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfl

EEMNKTQRRSG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
|..|. |...    . .||||||. .||   |    . ... ...|.   ||. .. || | |. | ||| .||| ...... |..
edvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_CG7180_pd Subfamily CG7180 206-449 2.2e-49 162.7 In-house 20-275 (296) alignment 
Range on Protein: 206-449
Range on HMM: 20-275/296.0
KQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVT
|.     . |.  .    . ..|.  ||  .|. || ||..|. |  .|  ..|||||...|..     || |..|. .|. .||||...|. . .|..|
klelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGee..ksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

NLMEGGRnKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILL---------GSDQPPLMITQYHFTSWPD-HGVPEYATSILQFHRRIKN----
. ..  . ....|||      ||.. | .. .. ... . |...|            . . .  .......| |.  . ||  ....... ||..     
ktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrek

-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQT
 . .|..||..|..| |..|.| ..|||. |...|||. .|.   . ..|..|  .|..
vdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven
subfamily_PTPN12_pd Subfamily PTPN12 464-727 2.5e-49 162.7 In-house 4-277 (290) alignment 
Range on Protein: 464-727
Range on HMM: 4-277/290.0
ETGQTGYNKQFTVLEQVTQKP--DE---VTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMI
..|.  ..|.|. | ....|   ..    ..  ...|. |||    || |. ||.|. ..     .|||| ..   ......| | .|.  |. .||.||
kegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmi

EDINVTAIVMLCQEKENDEEVCYKYWPTEATEVI-FGEYSIKLLNEELYD-LYTERTIEIKNKmkgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMN
 . ||. .||.|.| |..   | .||| |  | . |||....| .|.  |  .. ||......   . ..|| |.. | |   |  . .. .| ..|...
weknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvr

KTQRrSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
..|. | .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  ||| |||. ... |  ..
elqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 491-728 5e-49 161.8 In-house 40-278 (315) alignment 
Range on Protein: 491-728
Range on HMM: 40-278/315.0
IASQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT-EAT
  ..|  |||    || |. ||.|    .  . .|||| |. |... ||.| .  |  ..| .||.|. . .||.|||. . .|.|   | .|||  .| 
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

EVIFGEYSIKLLNEELYDLYTERTIEIKnkmKGGSRHKVVQYQITGWEPNGEVTcHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTIN
 | ||.....||. |     . | . ..   |. . ..| |.| |.|  .|    ... |. |    |..... . |..||||  |||. .....   ..
svefGsikvellsleadtdgvarklvtr...kseesrtvtqfqftewPdkGvdk.qtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevva

KCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
. | . ..|||...|  | ..|  ||| |.|  |...|. .| 
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
0041856 (Phosphotyrosine protein) phosphatases II 228-450 1.7e-48 160.0 In-house 1-157 (182) alignment 
Range on Protein: 228-450
Range on HMM: 1-157/182.0
NKPLNRFRNVLVYDDNRiilkplpshegcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTnlmeggrnkCHQYWPdsdsvyy
|...||....| || .|             .|||||....|.  | |.||||||. .|. ||.|...... ..||..|         ...|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

gpfkvtlidkqvlpdytvrelqlillgsDQPPLMITQYHFTSWPDHGVPEyATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQaeke
                            .  . ...||....|||||||.   ..|.| .....     .|| |||||||||||||. |... ...    
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....

gGIDIISIINRMRQQRMFMVQTR
 |... .... .|..|. ||.| 
.gvsleeavklvrsrRpgmvitp
subfamily_CG7180_pd Subfamily CG7180 484-726 3.6e-48 158.7 In-house 31-289 (296) alignment 
Range on Protein: 484-726
Range on HMM: 31-289/296.0
PDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK---G-QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEeVCYKY
 ..  ... ..|..|||  . .|.|. ||||.   | .. .|||||||||.   |..|. | |. .|| .||... | .. |.|.|... .  .  . .|
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPTEAtEVIFGEYSIKLLNEELYDLYTERTIEIKNK-------MKGGS--RHKVVQYQITGWEPNGEVTCH-QAILMILEE----MNKTQRRSGNTSIVV
|| .. .  .||  .....|. |   . ||. .. |       .|. .     | ..|.| || . .|    .|.. ...     ..|.. .  .  .||
wpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvv

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..||.|| |..... .
vssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 461-729 3.7e-48 159.1 In-house 8-278 (281) alignment 
Range on Protein: 461-729
Range on HMM: 8-278/281.0
QDPETGQTGYNKQFTVLEQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIED
|  .  ..|. .... |... .. .  |   | .|. ||| .     |. ||..    . .. .|||| .|..||. |..|....|. ... .||.|. .
qlsqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvwe

INVTAIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIknKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQR
 .|.||||. .| |..   |..||| ...|...|.. .| ..||    | ||....  ....|   .|.| . | |  .|  .  ...|   .|..|...
qkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlklte

RSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDS
.. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||| ||. .. .|  .|| 
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPRB_pd Subfamily PTPRB 467-727 4.4e-48 158.8 In-house 24-285 (293) alignment 
Range on Protein: 467-727
Range on HMM: 24-285/293.0
QTGYNKQFTVLEQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAI
........  |..| ..  .|. . ...|..||| |. || |. || |    . .. .|||| |.. |. .. || .  |. .|| .||.|. . ....|
dlrfseeyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssii

VMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNkmkGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQ-RRSGNT
||| |  |.  . | .|||.. ..|..|. ...|..|| .. .. |...|..   . ...|| ||. | |   |     ...| ......... . . ..
vmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
 ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||..||  | . |. .|
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 493-727 1.2e-47 157.1 In-house 41-276 (515) alignment 
Range on Protein: 493-727
Range on HMM: 41-276/515.0
SQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT-EATEV
  |  |||    || |. || |       . .|.|| |. |..  ||.| .  |  ..| .||... . |||.|.|. . ||.|   | ||||   .  |
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

IFGEYSIKLLNEELYDLYTERTIEIknkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMnKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKC
 ||.....|.  |     . |....   .||   . | |.. |.|  .|     ...| .. |. |...   . ....|||  |||  .....   . . 
kfGsikvelvsleactggikrkltv...lkgddsrtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvaha

KTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
||  ..|||....  | ..|  ||| |||  |...|. .|
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPN23_pd Subfamily PTPN23 464-724 1.6e-46 153.4 In-house 11-277 (288) alignment 
Range on Protein: 464-724
Range on HMM: 11-277/288.0
ETGQTGYNKQFTVLEQVTQKP-DEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKE-RKAFIIAESPMFSTVRNFWKMIEDINVTA
  |.|. .|.|  |||  .|   . .  ||  . .||||.  || |. ||.|.|.. .|||| .| .       ||.. .|. ||.  ||.|. .  .  
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLCQEKENDEEVCYKYWPTEATE-VIFGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNK---TQRR
|||| ...| ... . .|||..  | | ||..|. | ...  . . ||..... . .    ..|.  |.| |   |     . .| .|.|...   ...|
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqr

SGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
  .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||..||.|  .|.| 
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 483-729 3.5e-46 152.7 In-house 35-286 (297) alignment 
Range on Protein: 483-729
Range on HMM: 35-286/297.0
KPDE-VTHNIASQNK---DKNRSTQFLPPDNHRVVLKGQQPN----YINAVYVDSYKErkAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEe
 |   .. .  ...|   .|.| .  || |  || |.  . .    |.|| .| ..|.   .|  . || .|| .||.|. | .|..|||| ...|.|. 
lpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.

VCYKYWPTEATEViFGEYSIKLLNEELYDLYTERTIEIKnKMKGGSRHKVVQYQITGWEPNGEVT--CHQAILMILEEMNKTQRRSGNTSIVVHCSDTVG
 | .||. ...   ||. |..||  .    . .|..|.. | |  .|. | ||| . |  . .      ...| ...|..|.     .. ..|||.  ||
kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevt.kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvG

RSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDS
| .....    . . | |  .|.|...|  | ..|  ||| |||| ....|  .| |
rtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
0036282 (Phosphotyrosine protein) phosphatases II 258-450 1.4e-45 150.4 In-house 2-156 (174) alignment 
Range on Protein: 258-450
Range on HMM: 2-156/174.0
NDYINASFIDGYSSAYRYIATQGPMAntlvdFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDsdsvyygpfkvtlidkqvlpdytvrelqlillGSDQ
.||||||..|..    |.||.|||.|     ||....... ...||.....| |. ||..|||.                                 .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

PPLMITQYHFTSWPDHGVPEYATsILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEkEGGIDIISIINRMRQQRMFMVQTR
.  .. ||... |||||||. .. .|.| ..... ..   .||.|||||||||||||..|... |.. . |. .|..... ..|.||. |||| 
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 465-724 1.3e-44 147.6 In-house 20-285 (325) alignment 
Range on Protein: 465-724
Range on HMM: 20-285/325.0
TGQTGYNKQFTVLEQVTQKPdeVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQ----QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINvT
  | |. ..| .|  .  .    .     .||.|||    .. |. ||||. .    . .|||| |. ..|... |. | .|. .|. ..|... | . .
qdqdgfahefgllpsddgia..kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.c

AIVMLCQEKENDEEVCYKYWPTE-ATEVIFGEYSIKLLNEELYDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNK---TQR
..|..  | ..... | .||| | .  . ||   .||   | .  |  | ...|.  |.|    | |.|. .|.  |      ... ||. ...   . .
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqv.kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

R--SGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
    . | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.||.||  |.| . 
antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 468-723 3.8e-44 145.7 In-house 6-255 (267) alignment 
Range on Protein: 468-723
Range on HMM: 6-255/267.0
TGYNKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQ
. ..|.|  .......   ..  ||..|...||  . || |. ||.|. .. .|||| ||..|| ..|||. . |.  |. .|...| | .|. ||.| .
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

EKEndEEVCyKYWPTE-ATEVIFGEYSIKLLNEELYDLYTERTIEIknKMKGGSRHKVVQYQITGWEPNGEVTCHQAILmiLEEMNKTQRRSGNTSIVVH
  .  ...  ..|| . .    . . ...   |.  . |   |.|.  |.|  | |.|. |    |. | .   .   |  .  . | |   ||  .||.
vft..dnir.lfwPPkmgqakkyqdltvehslekeendyqiitlel..kfknesahnvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvva

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
||| ||||  |  . . ... ||||| |.|. |.  | |..| |.| |.|  | |..
csdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 466-721 4.6e-44 146.0 In-house 32-285 (319) alignment 
Range on Protein: 466-721
Range on HMM: 32-285/319.0
GQTGYNKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQ----QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTA
 .| .. .|  . ... .  . |.    ||||||| .. |. |. .| |.        .|||| .|. |. .. .| |  |.  |. .||.|| . |...
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IVMLCqekendEEVCYKYWPTEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEE-MNKTQRRSGN
||.|       .. | .||| .. .   ... .|.   |  . |. | ||. .. |     |. |. . ||   |       ......     |..  ..
ivllt......kdkcsqywplkivi.keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
..||||||  |||. .. .  . ... | |  .||.....  | |..  || . ||| |. 
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 188-452 5.6e-44 144.9 In-house 13-271 (290) alignment 
Range on Protein: 188-452
Range on HMM: 13-271/290.0
KFGEFVADGHANNDEEFMKQYALFHND-LDKHEMTISVSQKNK--PLNRFRNVLVYDDNRIILKplpshEGCQNDYINASFIDGYSSAyrYIATQGPMAN
 | .| .|    | .|. |.|       |  . .  .. .||     ||...|   |  |.|||     .| . ||. | ...|  .   .| |||....
afekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk.....dGydGdyvhanyvkGlkam..filtqGalkd

TLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSD--SVYYGPFKVTLIDKQvLPDYTVRELQLILLGSDQP-PLMITQYHFTSWPDHGVPEYATS
| .|.||.. |||  .|||. .|.| |. ||.||.|. .   . .| . |.   ..  .|  .    | .   |.    ..  ..  ||||. |.  . .
tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseed.dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstla

ILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
.|.  | ...    . ||. ||||||.||||||.||..|||   .   .|.. ..  .|. |.  ||   .
llrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiq
0049772 (Phosphotyrosine protein) phosphatases II 189-444 1e-43 145.6 In-house 9-255 (314) alignment 
Range on Protein: 189-444
Range on HMM: 9-255/314.0
FGEFVAdgHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDdNRIILkPLPSHEGcqNDYINASFIDGYssaYRYIATQGPMANTLVD
|.|.    | .  .....   . .. | .. ....   .|.  ||. ..| .| || || |  ...|   ||||||..||.    ..||||||. .|.||
fselli..hddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsg..sdyinasyvdgf...lkfIatqgpleitvvd

F----------WRLI--WQEKPHVIVM---------------------VTNLMEGGrnkchQYWPDSDSVYYGpfkvtlidkqvlpdY-------Tvrel
|          ||..  .. ....|||                      ..|...|      ... .|  ..                            
freepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk..............eelydpelf....

qlillgsdqpPLMITQYHFTSWPDHGVPeYATSILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAekegGIDIISIINRMRQQRM
          . .. .|. . .||...|     ...| . |..   ...|| ||||.||.||||||..... . .     |...  .....|..|.
..........erlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRp
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 485-721 1.1e-43 144.8 In-house 15-249 (284) alignment 
Range on Protein: 485-721
Range on HMM: 15-249/284.0
DEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQ----QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCqekendEEVCYKYW
 . |.    ||||||| .. |. |. .| |.        .|||| ..  |. .. .| .  |.  |. .||.|| . |...||.|       .. | .||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PTEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEE-MNKTQRRSGNTSIVVHCSDTVGRSAMFCA
| .. .   ... .|.   |  . |. | ||. .. |     |. |. . ||   |       ......     |..  ....||||||  |||. .. .
plkivi.keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
  . ... | |  .||.....  | |..  || . ||| |. 
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
0043147 (Phosphotyrosine protein) phosphatases II 258-450 1.7e-42 140.4 In-house 5-147 (172) alignment 
Range on Protein: 258-450
Range on HMM: 5-147/172.0
NDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLmeggrnkchqywpdsdsvyygpfkvtlidkqvlpdytvrelqliLLGSDQ
.||||||..|.|    |.||||||. ||| ||||...... ..||..|.|                                            |.  ..
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpel

PPLMITQYHFTSWPDHGVPeYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRMFMVQTR
   .. ||....|||||||  .  .|.| . |..   .  .||.|||||||||||||. |... |       |...  ... .|..|. .||. 
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp
0046846 (Phosphotyrosine protein) phosphatases II 254-450 2.1e-42 140.2 In-house 8-159 (176) alignment 
Range on Protein: 254-450
Range on HMM: 8-159/176.0
EGCQNDYINASFIDGYssayRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYgpfkvtlidkqvlpdytvrelqlill
..   |||||..|.|.    |.||||||. .|| ||........ ...|..|...| || ||..|||.  .. .                          
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

gsdqpplmitQYHFTSWPDHGVPEYaTSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDmglqQAEKEGGIDIISIINRMRQQRM-FMVQTR
          ||... |||||||.. . .|.. . |.. .|   || |||||||.|||||. |..      |.| |...  .. ..|.||. ..|||.
..........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp
subfamily_PTPN9_pd Subfamily PTPN9 462-722 2.7e-42 139.8 In-house 10-285 (297) alignment 
Range on Protein: 462-722
Range on HMM: 10-285/297.0
DPETGQTGYNKQFTVLEQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDI
  |.|. |  |... . . . .  ....     |  ||| |  |  |. ||||.     .. .|||| .|| ||..|||| .  |.  ||..||.|. . 
vkekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeq

NVTAIVMLCQEKENDEEVCYKYWP-TEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQR
.|  |||  .  |.    | .||| .| .   ||..|.. .. | .. |..|..||||  .. || ||. .|...|   |     ...| .||.. ..| 
evlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesr.kvthfqflsWPdyGvPssaaslldvlekvrekqa

RS------------GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEI
 .             .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.|| |||.  .  
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 493-728 1.3e-41 137.6 In-house 26-269 (274) alignment 
Range on Protein: 493-728
Range on HMM: 26-269/274.0
SQNKDKNRSTQFLPPDNHRVVLKGQQ-----PNYINAVYVDSYK-ERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATE
. .. ||| .. || .| ||.|. ..      .|||| |.  |. | ||.. .  |. .|| .||.||   .|. |||| . ||..|. | .|.|..   
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

VI---FGEYSIKLLNEELYDLYTERTIEIKNKMKggsRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNT--SIVVHCSDTVGRSAMFCAAA
 |   .|. .||  .    . |. |.. .|.  .   ...|. |  | |  .      ...| ...|........ .   ..|||||  .||  .| |. 
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
 .... . |.|.||...    |... | ||| |||. |....  || 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0049260 (Phosphotyrosine protein) phosphatases II 265-450 2.4e-41 136.3 In-house 1-136 (152) alignment 
Range on Protein: 265-450
Range on HMM: 1-136/152.0
FIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWpdsdsvyygpfkvtlidkqvlpdytvrelqlillgsdqpplmitQ
|||||   ...||||||. ||| ||||.... . ..|||.|.|.| |. ||.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRMFMVQTR
|... |||||||. .  .|.... |.  ..  .|| |||||||||||||..|... |       |...  .....|..|. .|.. 
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnp
subfamily_PTPN3_pd Subfamily PTPN3 486-728 3.9e-41 135.8 In-house 30-277 (280) alignment 
Range on Protein: 486-728
Range on HMM: 30-277/280.0
E--VTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDS----YKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKY
.  ...   ..| .|||    || |. || || .. .|||| ||.      .  . .|..  |. .|. .||.|. . ... |||| .  |.    |..|
glaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKtQRRSGNTSIVVHCSDTVGRSAMFCA
||..  |. .||.|.|. .|.    |  | . .|.| .  .| |..| | . |  .|  . .. .| ..|...| .|.. .. .|||||  .||. .. .
WPetedeleygefsvkcekedetksyvlrelvlkdketkeer.kilqlqylaWpdhgvPddsadflefvervrk.lrsgkeePvvvhCsaGigrtGvlil

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE-IVQIYLD
  |.. .  ..  . . ....  | |.   |||..||| . | |...| .
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 494-727 1.1e-40 134.2 In-house 37-277 (287) alignment 
Range on Protein: 494-727
Range on HMM: 37-277/287.0
QNKDKNRSTQFLPPDNHRVVLK--GQQ-PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIFG
 .  ||| .. || |. ||.|   |..  .|||| || ||.. .||| | .|. .|||.||... . ........ .| |.    ||||||     .  |
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYSIKLLNEELY-DLYTERTIEIKNkMKGGSRHKVVQYQITGWePNGEVTCH--QAILMILEE---MNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTI
 ||. ||. .     |. |.. . . ...   . | |...  | |.. ..      | ..|.    .. ..  |.   .|||..  .||| .. |  . .
GysvvlldydikePeygvralrlid.letrearvvkqldllsw.PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

NKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
.. .  | .|| .|.   | .. . ||.| |.. ..| .  | 
srledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 491-728 6.5e-40 131.8 In-house 16-265 (270) alignment 
Range on Protein: 491-728
Range on HMM: 16-265/270.0
IASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSY-KERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEAT
 | ..|  ||... ||  . ||.|.     .. .|||| ||  . .|.|..| | .|. .|...||.|| . .||||||. . .|.  . | .|||.|. 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

E---VIFGEYSIKLLNEELYDLYTERTIEIKnkmKGGSRHKVVQYQITGWEPNGEVTCHQ------AILMILEEMNKTQRRSGN-TSIVVHCSDTVGRSA
|   . .|. ..  |.||  . |  . ....   . |.....| .. . |  .| .. ..       .| .|... .....  . . ..||||. |||. 
ekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
.. |  ....  .... .|| ....  | ...  ||..|||. ... |..| .
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 216-452 8.9e-40 131.4 In-house 21-247 (267) alignment 
Range on Protein: 216-452
Range on HMM: 21-247/267.0
DKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLmegGRNKC
..  .. |...||.  ||. ..| |||.|.||.        ...|||||...||     .|.||.|. ||  ||. .| ..|  |||..|.    . .. 
tsstisqsiaeknqernrlddnlpyddtrvilr......tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdni

HQYWPDS--DSVYYGPFKVTLIDKQVLPDYTVRELQLILlgSDQPPLMITQYHFTSWPDHGVPE-YATSIlqFHRRIKNEYKPTKGPMLVHCSAGVGRTG
...||    ..  |  . |    ..   || .  |.| .   ..    .| |..  |      . |   .  |    ||. .    |..|.||.||||.|
rlfwPPkmgqakkyqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrsG

TFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
||. ||  |..| .||  ||   . ..|.||. .|.|. |
tflvidsqleraktegvsdifdflrkirsqriglvdtker
subfamily_PTPN1_pd Subfamily PTPN1 478-717 1.2e-39 130.8 In-house 13-261 (290) alignment 
Range on Protein: 478-717
Range on HMM: 13-261/290.0
EQVTQKPDEVTHN--IASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEV
...... ......     .|...||     | |  |..|. .. .||||  |.  . .. .|..  |. .||  ||.|. . .  |.||| .  |...  
ldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CYKYWPTEAT--EVIFG--EYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGN-TSIVVHCSDT
|..|||..    |...   ....||..|| .. || |..|..|.    .| .....  | |   |   . .| |  | .. ..   | .    |.|||  
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetr.eilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYK
.|||  || . | .    | .    .|. .||   | .. | .|| .| .
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlr
subfamily_PTPN13_pd Subfamily PTPN13 471-723 3.6e-39 129.7 In-house 14-265 (273) alignment 
Range on Protein: 471-723
Range on HMM: 14-265/273.0
NKQFTVLEQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPnYINAVYVD--SYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQE
...|. |...  . |...     .||||||  . || |. || |... . |||| ..     |..  .|..  |.  ||..||.|. . ... |.|. .|
aeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

KENDEEVCYKYWPTEATEVI--FGEYSIKLLNEELYDLYTERTIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrsGNTSIVVH
||...  | .||| .. . .   . . ..||. . .| .. |....|..  | | ..|.. . . |   |  .  . .| .. |... |.   .. ||||
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvh

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
||  .||| .. .  . ..  . .  .|| ..... | |. | ||| .||  .....
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 212-452 4.8e-38 125.6 In-house 34-275 (305) alignment 
Range on Protein: 212-452
Range on HMM: 34-275/305.0
HNDLDKHEMTISVsqKNKPLNRFRNVLVYDDNRIILKPLPSHegcqnDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGG
 ||..| .       ...  ||...|   |.||. |..   |     .|| | ..   . . |.| || |. .|  ||| . .|.| . | |. ||.| |
fndfekmkafkea..qeagknrykdvgcldnnrvklegpwph.....eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekg

RNKCHQYWPDSD--SVYY--GPFKVTLI-------DKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRriknEYKPTKGPM
 .||..|..  |   . .  .  |...        . .   . .|.| .|.. |. .  . .|.||.  ||| |||   ..||..      . .|.|||.
akkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle....karpskgpi

LVHCSAGVGRTGTFMAIDMGLQQAEKEGGID-IISIINRMRQQRMFMVQTRAR
 ||||||.||||. . ..  |.|      |.    |....|.||   .|| |.
vvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 218-454 1.3e-37 124.5 In-house 31-267 (307) alignment 
Range on Protein: 218-454
Range on HMM: 31-267/307.0
HEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpsHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQ
. .|.   . |   ||...| . | .||..|     .|   ||| | ..       ..|..|||. ||  .|| .. |||   ..|. ...| .. ||.|
egvtveafsantdknryqdvkcqdkgrivvk....fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceq

YWPDSD--SVYYG--PFKVT---LIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGR
|||  .     .|  |  ..   |  |.. ||  . ..  . .   |    |... .. |||.|||.   . . .   .. .    . |..|||||||||
ywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhcsaGvGr

TGTFMAIDMGLQQ-AEKEGGIDIISIINRMRQQRMFMVQTRARSM
.|| .|| .  ..  . .   |.  ... .|.|| . .|| |. .
sGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyl
subfamily_PTPRN_pd Subfamily PTPRN 471-723 1.4e-36 120.8 In-house 32-288 (297) alignment 
Range on Protein: 471-723
Range on HMM: 32-288/297.0
NKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQ----QPNYINAVYVDSYKER-KAFIIAESPMFSTVRNFWKMIEDINVTAIVML
.|..  | .  ..|   .   | .| .||||...|| |. || || .    . .||||  .     |  |.| ...|. ||| .||.|. .  |. ||.|
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

CQEKENDEEVCYKYWPTEATEViFGEYSIKLLNEELY-DLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRsGNTSIV
.. .|.. . |..||| | .|| .. | ..|. | .. | |  |.. .||  .  .|  | |.    |. .|  .  ...|     .||. |    ..||
trleeegvkqckrywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetr.tvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpiv

VHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
||||| .||. ....    .|.  |    ||.   |.  | |.|| |.| .|.. ..  |
vhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
0051082 (Phosphotyrosine protein) phosphatases II 258-451 5.1e-36 118.9 In-house 3-140 (151) alignment 
Range on Protein: 258-451
Range on HMM: 3-140/151.0
NDYINASFIDGYssayrYIATQGPMAntlvDFWRLIWQEKPHVIVMVTNLMEGGrnKCHQYWPDSDsvyygpfkvtlidkqvlpdytvrelqlillgsdq
.||||.|...|.     .....||.|    ||..|.....  .||......| |  .|..|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

ppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekeggIDIISIINRMRQQRMFMVQTRA
  . ........|||.|.|..  ..|.|.. . .   . .||.|||||||.|||||..|... |..      ... .... .|..|. .||.  
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 221-451 5.9e-36 118.9 In-house 28-257 (285) alignment 
Range on Protein: 221-451
Range on HMM: 28-257/285.0
TISVSQKNKPLNRFRNVLVYDDNRIILKplpSHegcQNDYINASFIDGYS-SAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYW
| .  . |  |||. .| . .. |..||    |   . ||| ||..         ||.||||. .|| |||..|.|||   ..|.  |.||| .||  |.
tytayeanpdlnryadvrcieetrvvlk...nh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PDS--DSVYYGPFKVTLIDK--QVLPDYTVRELQLILLG-SDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKGPMLVHCSAGVGRTGTF
|.   . | .| ...|| .   . .    .  | .|    .   || . . .   |||.  || |  ...... .|.  .| . |. |||||||||| ||
peklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatf

MAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
. ||    .  ..  |... |.  ||  |.  ||.. 
vgidyatirimenpniemldivremramrfqavqshm
0044763 (Phosphotyrosine protein) phosphatases II 240-450 1.2e-35 118.2 In-house 2-157 (178) alignment 
Range on Protein: 240-450
Range on HMM: 2-157/178.0
YDDNRIILKPLPSHEGcqNDYINASFIDGYssayRYIATQGPmantlVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSvyygpfkvtlidkqv
.|..| .| .|. .|.   ||||||.|...     |.....|     .|...|..... ..||..|. .|.|..||..|||.. .               
ldrtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

lpdytvrelqlillgsdqpplmiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekegGIDIISIINRM
                        ||... .||||||.    .|.|.. |.. ... .|| ||||||||||.||..|... ...     |... ..|...
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielv

RQQRMfMVQTR
|..|. .|...
rerRp.ivpnp
0051429 (Phosphotyrosine protein) phosphatases II 519-731 1.2e-35 118.8 In-house 4-229 (272) alignment 
Range on Protein: 519-731
Range on HMM: 4-229/272.0
PNYINAVYVDSYKE---RKAFIIAESPMFSTVRNFWKMiEDINVTAIVMLCQEKENDEEVCYKYWP-----------TEATEVIFGEYSIKLLNEELYDL
..|||| .|. |     ..... .  |.  |...||.. .. ....||.|..| | . . |..|||           ..|... .| ....|| |||.. 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTchQAILMILEEMNKtqrrsgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------VF
|. |......... |  ..| ... |.|   |  .  .|.| .||....      .  ..||||  ..|.....|.   .     | ..|        ..
yilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFM
....  | | ||.||| |||. ..|... .|.|..
eaveelraqrpgavqteeqylflyeallellrsll
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 210-454 1.6e-35 117.2 In-house 19-259 (281) alignment 
Range on Protein: 210-454
Range on HMM: 19-259/281.0
LFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKP-LPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLM
 .  |      |.     |.  ||. |. . |  |. ||  .| ..    ||| | .|        || ||||  .|  ||||.||||.   |||. ...
nlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnkn..stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfl

EGGRNKCHQYWPDSDS--VYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSA
|  |.|| .|.|      . .  . |.  |  |        |.|   |  .   .||.. .  |||  ||| .  .|.  |.|.        | ..||||
etnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetr...lithwlwkewpdwqvpessevmlkilrkirarst....ppvihcsa

GVGRTGTFMAIDMGLQQAEKEGGI-DIISIINRMRQ-QRMFMVQTRARSM
||||.||.||... ||       . ||  |. ..|   |   |||  . |
gvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqym
subfamily_ptpA1_pd Subfamily ptpA1 208-417 6.2e-35 115.7 In-house 27-249 (418) alignment 
Range on Protein: 208-417
Range on HMM: 27-249/418.0
YALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSsAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNL
. |. . .   | .    ..|   ||. |.|  .  |. || .  .||  .||||| .|||     ..|.||||. ||. ||||..|... ..|||..  
frlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkeg..sdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsre

MEGGRNKCHQYWPDS-----DSVY------YGPFKVTLIDKQVLPDYTV--RELQLILLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-
 |  | || .|||.       |.|      .| . | |..    |.  .  |...| . |  .    ||||..  |||| .|...  . |. . | |   
sencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetr...ditqyqyegwpdhnipdhtqpfrqllhsitnrqn

--KPT---KGPMLVHCSAGVGRTGTFMAI
   |.   . |..||||||||||||| . 
qiipssdrnvpiivhcsagvgrtgtfcta
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 494-721 8.5e-35 115.1 In-house 2-233 (237) alignment 
Range on Protein: 494-721
Range on HMM: 2-233/237.0
QNKDKNRSTQFLPPDNHRVVLKGQ--QPNYINAVYVDSYKE-RKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIFG
.|| |||  .    |  ||||||   . .|||| |....    | .| |. |. |.  .||.|. . . . ||||    |..|. |.||||       .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

EYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEM-NKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 ... |  .| .  || |.. . ....      . |||.| |  .|      |.| .  .. |...  |  .  ..|||  |||...|    . . ..| 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

EGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
. |.|... ..|   ..|  .|| .||  |..
kkvvdiynyvysieedrpyiiqtkdqyvfihq
0036282 (Phosphotyrosine protein) phosphatases II 520-720 8.9e-35 115.3 In-house 3-163 (174) alignment 
Range on Protein: 520-720
Range on HMM: 3-163/174.0
NYINAVYVDSYKERKAFIIAESPMFstvrnFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTeatevifgeysikllneelydlytertieiknkMKGG
.|||| ..| .   . .|.   |.      ||.|. . ..|..|||..|||.. . |. |||.                                 ..  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lred

SRHKVVQYQITGWEPNGEVTCHQaILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVEQYKGI
 .. ..||. ..|. .|. . .. .| ....... . ....  ..||||  |||.....||   .   . |...|........| |.||.||| .||. .
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

F
 
y
subfamily_PTPN14_pd Subfamily PTPN14 472-728 2.2e-34 113.8 In-house 24-297 (300) alignment 
Range on Protein: 472-728
Range on HMM: 24-297/300.0
KQFTVLEQVTQKPDEVTHNIAS--QNKDKNRSTQFLPPDNHRVVLKGQQ---PNYINAVYVDS--YKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVM
| ||  |....|  . . . |.  .|..|||  ..|| .. || |. ..    .||||  .      ... .|.| .|.  ||..||.|. . .|. |||
kvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LCQEKENDEEVCYKYWPTE---ATEVIFGEYSIKLLNEELYDLYTERTIEIKNkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNT
| .|.|.  | ..||.| .   . .| ||.. .     |  | .. .....|  .  . . .|.  | | |  .|     .  |  |||..  .|.. ..
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkh.lpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnse

S--------IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
.        ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. ||| .....  ||.
veskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 362-615 2.1e-33 110.3 In-house 91-314 (440) alignment 
Range on Protein: 362-615
Range on HMM: 91-314/440.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRARSMIgkLSE
. |||. .|||.|||..|  .|.. . ... . |  .||.|||||||.||||  .|.|  |..|..   |||.|.|| ||..|  ||||  .  .  . |
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf..vhe

QDPETGQTGynkQFTVLEqvtqkpDEVThniasqnkdkNRSTQFLPPDNHRVVLKGQQPnyinavyVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVT
   |   .|   .  .||      |..|          .|  |   |. |      ||        .. |  ..||| .. |. ||| .||... | ...
avlegllcg...dtlile......ddit..........erveqiqwpnphtdksplqqe.......fegyskknafiatqmpldstvldfwrlvhdyris

AIVMLCQEkeNDeEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNK
.|.|| |   ||   |  ||| ..  | || ...     |  .    ||.|.| |
tiimlnql..nd.ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk
0041856 (Phosphotyrosine protein) phosphatases II 495-723 9.8e-33 108.7 In-house 1-167 (182) alignment 
Range on Protein: 495-723
Range on HMM: 1-167/182.0
NKDKNRSTQFLPPDNHRvvlkgqQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCqekendeevCYKYWPTEAtevifgeysi
|.|||| . .||.|. |       ..|||| .....   . ||..  |. ||| .|..|. . ..|.||.|.         .. |||..           
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell..........

kllneelydlytertieiknkmkggsRHKVVQYQITGWEPNGEVTcHQAILMILEEMNKtqrrsGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvID
                           . ..||. ..|. .|  .  . .| ..||...      .  ..||||  |||.....||   . .    | ..
..........................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vs

VFQVLKSQRIQKPGSVQTVEQYKGIFEIV
.....|  | ..||.|.| .||  .  ..
leeavklvrsrRpgmvitpnqyfflqlal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 220-386 1.7e-32 107.5 In-house 23-190 (297) alignment 
Range on Protein: 220-386
Range on HMM: 23-190/297.0
MTISVSQKNKP--LNRFRNVLVYDDNRIILKPLPShegcQNDYINASFID--GYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKC
 . |....|     ||.|..| .||.|. |.  ..    ..||||| ..      . ..|| .|||. .|. |||.|....   |||||..| |.||.||
esfssakrnsslrknryrdilatddtrvkllrvit....erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

HQYWPDSDSV--YYGPFKVTLIDKQvLPDY---TVRELQLILLgsdQPPLMITQYHFTSWPDHGVPEYATSILQFH
  |||...      | . |  . .    ..    . |||||     .   ...   | ||||||||     . .|.
apywpsvvqerlkagdvvveflsst.sdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 202-453 7.6e-32 105.1 In-house 27-279 (310) alignment 
Range on Protein: 202-453
Range on HMM: 27-279/310.0
EEFMKQYALFHNDLDKhEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPShegCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVI
| ..|||  .  . |   .|    .|.   ||. .|.. |. |. ||   |     .||| | ..        .| .|||.  |..||||.|.||.   |
eglvkqyrkldakqds.sltyeaykkymhknrysdvvcldtsrvklkidks...ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesi

VMVTNLMEGGRNKCHQYWPDSD-SVYYGPFKVTLIDKQVlPDYTVRELQLILLGS-----DQP----PLMITQYHFTSWPDHGVPEYATSILqfHRRIKN
... . .| || ||  |||    .  ||  .|| . .    .. . .| . ..       .||     | ..  ..  ||| |||.     .   .|.  
lllckvgeegrpkcvgywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv..pqrlla

EYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRARS
. .  .|| .||||||..|... .|... ......   .|.  ..  ....|.  .||  . 
qvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 486-723 8e-32 105.0 In-house 45-279 (290) alignment 
Range on Protein: 486-723
Range on HMM: 45-279/290.0
EVTHNIASQNK--DKNRSTQFLPPDNHRVVLK-GQQPNYINAVYVDSYKerKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT
 .  .|  .|    |||  .    |  ||.|| |.. .|. | ||.  |    ||... .. .|| ..|.|. . .|.||||||.  |.    | .|.| 
ylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype

EATEVI-FGEYSIKLLNEELYDLYTE-RTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMnktQRRSGntSIVVHCSDTVGRSAMFCAA
.. ||. |||...   .|.  |  .  .|. ...| . |  ||.  ..|  |  .       |.| .|  .   .. ||   .|||||  .||.  | | 
keGevltfGeitvlcseeddkdaniikktlsvrdk.dsGkehklkhlkikswpdksvalstlallrtlril...rkasG..pvvvhcsaGiGrtGtfvai

ATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
 ... .. ..|  .|. .. .. |  . .|||   ||  . ||.
evgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil
PTPc_DSPc_SM00012 362-451 9.9e-32 104.6 In-house 2-94 (105) alignment 
Range on Protein: 362-451
Range on HMM: 2-94/105.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK--GPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMFMVQTRA
...||.|.||||||||...|||.. | .|....  .  .|..|||||||||||||.|.|. ||| ||| . .||  |....|.||. |||| .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 491-723 1.4e-31 104.2 In-house 41-232 (392) alignment 
Range on Protein: 491-723
Range on HMM: 41-232/392.0
IASQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDeevcykywpteate
    |. |||  . || |. ||.|       . .|.|| |..|..  ||.| ...|  ... .||.|. . |||.|.|. . || |              
qkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..............

vifgeysikllneelydlytertieiknkmKGGSRHKVVQYQITGWePNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINK
                              || . . | |...| | |. .|  | . |. . .  |..  .    ...|||  |||...  .  . . .
..............................kgddartvaqfhftew.PdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvah

CKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
.|.  ..|||...   | ..|  ||| |||  |.  |
akktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 260-451 3.3e-30 99.9 In-house 77-268 (301) alignment 
Range on Protein: 260-451
Range on HMM: 77-268/301.0
YINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPD--SDSVYYGPFKVTLIDKQVL-PDYT-VRELQLILLGS
 | | .|.    . |.||||||. ||  ||| .. | . . |||... .|   .||..| |   |...  | ||... .|...  . .  |.|..     
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

DQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
. ..  .| | ...|.|.|||.  . . ..   .|.    .. |..||||||.||. .|.. ..  .. | .  |..   ....|..|   |||. 
kfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtns
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 461-716 4.1e-30 99.6 In-house 16-270 (301) alignment 
Range on Protein: 461-716
Range on HMM: 16-270/301.0
QDPETGQTGYNKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFlP--PDN-HRVVLKGQQpNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDI
.| .     ||  .  ..  | . |..|.  |  .|||.|  .  |  |.   .|. .|..   | | ....  . . ||.. .|. .|  .|| |.   
kdddktakfynttienvnvttidkdhitesyaylpkdkhryptv.PckPstavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqy

NVTAIVMLCQEKENDEEVCYKYWPTEATE-VIFGEYSIKLLNEE--LYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEeMNKT
.|  ||||.|. |. ||.| .| |.. .| .  | ..||. |.|  | .  ..||.|...  .  . . |. || . |  .|    |  .  ..| . | 
dvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkk

qrrSgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQY
   | .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||..| 
...s.ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 227-450 5.2e-30 99.1 In-house 54-275 (305) alignment 
Range on Protein: 227-450
Range on HMM: 54-275/305.0
KNKPLNRFRNVLVYDDNRIILKpLPShegcQNDYINASFIDGY-SSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSV
 ..  ||...| . | . . |.  ||      ||| | ..        |.|..|||. .|. .|| .. |.|   |||. . .| |. || |||| .   
iaitknryqdvpcqdqsavkld.kps....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

YYgPFKVTLIDKQVL---PDYTVRELQLILLG---SDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDM
    .|  .. ..|    |     |.|. ||    | .  . . . ..| ||| |||    . |..   |.     .| |..||||||.||||| .||. 
kl.elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaiey

GLQQ-AEKEGGIDIISIINRMRQQRMFMVQTR
 |.. ||.     .  ... .|.|| | .|. 
ilekiaenkpcppmpelvkalrdqrafsiqnd
0046846 (Phosphotyrosine protein) phosphatases II 516-728 2.3e-28 94.5 In-house 9-174 (176) alignment 
Range on Protein: 516-728
Range on HMM: 9-174/176.0
GQQPNYINAVYVDSYKerkaFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIfgeysikllneelydlytertieiknk
.  ..|||| ......    .|.   |. .|. .|..|. . ..||.|.|..|.| .   |. ||| . .. |                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

mkggsrhkvvQYQITGWEPNGEVTChQAILMILEEMNKTQRRSgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTVE
          ||. ..|. .|  .  ...| .||.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.||| |
..........qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYKGIFEIVQIYLD
||. . | .. .|.
Qyrflyefellllk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 222-451 1.1e-27 91.8 In-house 37-258 (288) alignment 
Range on Protein: 222-451
Range on HMM: 37-258/288.0
ISVSQKNKPLNRFRNVLVYDDNRIILKplpshEGCqNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPD
|..  .|   .|..|.   |  |. |.     . . . ||.|  .       | | .| |.  |.  .|... ..  . |||...|.| |..|  .|.| 
idsfianptrdryenlprcditrvkls.....ddp.dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs

S--DSVYYGPFkVTLIDKQVlpDYTVRELQLILLG---SDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMA
   ... .| .  | . |.   .   . ... ||      . . .. . |.  |.|.||||   | |..  ..|.  |    |..||.|||||||||.. 
klGekarigrl.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtlil

IDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
| . |...  .  . | |.....|..|.  .||  
ilialeslrlddflgirsllaklreerfkaiqtem
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 467-723 2e-27 90.7 In-house 19-275 (439) alignment 
Range on Protein: 467-723
Range on HMM: 19-275/439.0
QTGYNKQFTVLEQVtqKPD-EVTHNIAS--QNKDKNRSTQFLPPDNHRVVLK----GQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINV
|  ... |  .. .  .|| ..  ..|.   .. |||  .  . |  ||.|.      .  |||| |.. | . | .| .. |   |. .||... . ..
qeifkeifekinst..spdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekkt

TAIVMLCQEKEndeevCYKYWPTEAtEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRH-KVVQYQITGWePNGEVTCH-QAILMILEEMNKTQRR
. ||||..  |      |||||..| ||..|. ...   .     |. | . . |.   . .   |.|.. . | |. .| ..   .|  |  .| .. .
vtivmltnlve.....sykywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiaw.pdknvpaqashvldflrainsandk

SGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
     .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||.. ||  |.. |
eeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
0049772 (Phosphotyrosine protein) phosphatases II 494-731 2e-27 92.1 In-house 45-284 (314) alignment 
Range on Protein: 494-731
Range on HMM: 45-284/314.0
QNKDKNRSTQFLPPDnHRVVLKG---QQPNYINAVYVDSYkerKAFIIAESPMFSTVRNF----------WKMI--EDINVTAIVM--------------
 |.||||....|| | .||.|.|   .  .|||| |||..   ..||... |.  || .|          |.|.  .|.||  |||              
lnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCQEKENDeevcykywpteateV--------I-FgeysikllnEELYDL--YtertieiknkmkggsRHKVVQYQITGWEPnGEVTCHQAILM
       |..  .|                                    |||||   .                . ...|  . ..  |..   . .. 
aAlgKtpllildgng..............neptaadlellk.........eelydpelf...............erlgikylripvpD.gsaplledfde

ILEEMNKTqrrSGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTVEQYKGIFEIVQIYLDSFM
.|| ...    . .. ..|||.. .||.. |..||  . ..   || .. ..|.  | . |     |.... |||  |.|... ||. ..
flefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 494-720 2.8e-27 90.4 In-house 7-234 (239) alignment 
Range on Protein: 494-720
Range on HMM: 7-234/239.0
QNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYK-ERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEvi
 || ||| .. .  |  ||||.      . .|||| |.  |    ||.| ..  .  .  .||.|. .     ||||    |  .. |..|||  ...  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..

FGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCK
. .  . | . |..  |  ||. . .  .    . | ||..| |  .|      |.| .  .. |     |    |.|||  |||.  |    . . ..|
ycnlrvtlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqak

TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
 .  .|.|. .|. | ..|  ||| |||  |.
kqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 495-720 3e-27 90.3 In-house 7-233 (239) alignment 
Range on Protein: 495-720
Range on HMM: 7-233/239.0
NKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYK-ERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEviF
|| ||| .. .  |  ||||.      . .|||| |.  |    ||.| ..  .  .  .||.|. .     ||||    |  .. |..|||  ...  .
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..y

GEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 .  . | . |..  |  ||. . .  .    . | ||..| |  .|      |.| .  .. |     |    |.|||  |||.  |    . . ..| 
cnlrvtlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakk

EGVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
.  .|.|. .|. | ..|  ||| |||  |.
qktvdifnyvkairedrphmvqtseqyvfih
subfamily_egg_pd Subfamily egg 203-449 3.3e-27 90.0 In-house 15-255 (307) alignment 
Range on Protein: 203-449
Range on HMM: 15-255/307.0
EFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKpLPSHeGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIV
|. ... . ..  |.  .| ..|. |.   | . |   |  |. |. |.      .|.| |  ..|      .| .| |. ||  ||||...||. . ||
elerrlevleesvdeislttaasdnnlekarskrvhckdssrvkle.lrrG.qylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyiv

MVTNLMEGgrNKCHQYWPD--SDSVYY--GPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFtSWPDHGvpeYATSILQFHRRIKNEYKptkg
|.|   |   ..|. |||   |||. .  | .... .. .  .|   |  .| |.|.|.  . .  .    .   .      | |.  |...|  |    
mltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss...dvysplrvlrklrnlsk....

PMLVHCSAGVGRTGTFMAIDMGLQQAEKEgGI---DIISIINRMRQQRMFMVQT
|..|..  || ...|..||.. | .  .   |    .   .  .|..| . |..
pvvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsves
0043147 (Phosphotyrosine protein) phosphatases II 520-720 4.4e-27 90.3 In-house 6-154 (172) alignment 
Range on Protein: 520-720
Range on HMM: 6-154/172.0
NYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEkendeevcykywpteatevifgeysikllneelydlytertieikNKMKGG
.|||| |.| |   . ||.   |. .|.  ||.|. . ..|.||.|...                                              . . .
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydpel

SRHKVVQYQITGWEPNGEVtCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVEQYKG
  . ..||. ..|. .|     . .| .|| ... . .| .  ..||||  |||.....||   .        . .......  | ..||.||. .||. 
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrf

IF
. 
ly
0048076 (Phosphotyrosine protein) phosphatases II 318-450 4.9e-27 89.8 In-house 2-129 (145) alignment 
Range on Protein: 318-450
Range on HMM: 2-129/145.0
YWPD--SDSVYYGPFKvTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFM
|||.   ...|.|..  | .| . | |. .. .  .    . .  ...||....|||||||. .  .|.| . |.. .|   ||.|||||||||||||..
ywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv

AIDMGLQqaekeGGIDIISIINRMRQQRMFMVQTR
|... |.      |... ......|.||...|.. 
aaylmll.....lgvsleealelvrsqrpgavpnp
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 272-447 8.5e-27 88.6 In-house 4-187 (199) alignment 
Range on Protein: 272-447
Range on HMM: 4-187/199.0
AYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDS--VYYGPFKVTLIDKQVLPDYTVRELQLILLGSdQPPL--MITQYHF
  |||||| |. .|. |||...|.     |||| .           ||| ..|    || . ||     . ||||.  | |    .  ||    |..| |
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt.appstreishyqf

TSWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMFMV
||| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  ..
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgii
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 472-726 9.1e-27 88.8 In-house 20-276 (307) alignment 
Range on Protein: 472-726
Range on HMM: 20-276/307.0
KQFTVLEQvtQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK--GQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEK
 .|.|| .  ..|. || .  | | |||| ..    |. |.|.|  |   .|| | |.    . | || |. |. .|. .|| |. . .| ...|||.  
defrvlak..ktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

ENDEEVCYKYWPTEA-TEVIFGEY--SIKLLNEELYDLYT-ERTIEIKN-KMK-GGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrrsgnTSI
|  .  | .||| |   . .|||   .| . |     |   |  |.. . |.. ..    . ..| . |  .|      . . .|| ..  .       .
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npv

VVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
|||||  ||||    | .   .|  . .   |. ....  | |.. ..||  ||  .  ..  |
vvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 273-447 9.9e-27 88.4 In-house 4-186 (198) alignment 
Range on Protein: 273-447
Range on HMM: 4-186/198.0
YRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDS--VYYGPFKVTLIDKQVLPDYTVRELQLILLGSdQPPL--MITQYHFT
 |||||| |. .|| |||...|.     |||| .           ||| ..|    || . ||     . ||||.  | |    .  ||    |..| ||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt.appstreishyqft

SWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMFMV
|| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  ..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgii
0049260 (Phosphotyrosine protein) phosphatases II 526-720 1.1e-26 88.8 In-house 1-143 (152) alignment 
Range on Protein: 526-720
Range on HMM: 1-143/152.0
YVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWpteatevifgeysikllneelydlytertieiknkmkggsrhkvv
..| |.  ..||... |.  |. .||.|. . ..|.||||... |.... |..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QYQITGWEPNGEVTCHQAILMILEEMNKTqRRSGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
||. . |. .|  . .| .|..|. ..|  ... .  ..||||  |||.....||   .        ........  | ..||.|.. .|.. ..
qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_CG42327_pd Subfamily CG42327 224-392 6e-26 85.9 In-house 24-193 (319) alignment 
Range on Protein: 224-392
Range on HMM: 24-193/319.0
VSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAY-RYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDS
|    |. .|. ||.   . |..|.  ....  .. |..||.. || .|   |||.| .. ..  ||||..|. .  ||| .|.| | | ..| .|.| .
vPvtskdksrvinvvPlPetrvvlqrigddd..kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk

DS----VYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQpPLMITQYHFtSWPDHGVPEYATSILQFHRRIKNE
..      || ..||| ...|   | .  | |  .  ..    .| | .  |.. .||   ....    .... 
etldntslyGdilvtlkgrevkdryaistlllkrvdkee.srelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 204-422 9.4e-26 85.2 In-house 21-234 (312) alignment 
Range on Protein: 204-422
Range on HMM: 21-234/312.0
FMKQYALFHNDLDKHEMTISVsqKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVM
. |.|    | .   | |  .  | | |||. |. ..|  |. |       | .| || | |.   .   |...||||. || . ||.|        |..
ltkeykavgnivsdsectafl..kfkdlnrypniqcwdrgrftla......gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiil

VTNLMEGGRNKCHQYWPDS--------DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPlMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykp
.. ..| | .|| .|  |           ||        |  .     | | |....  . |    . .| ..||||||.|.   . |..   .|..   
lcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrllsavkkd...

tKGPMLVHCSAGVGRTGTFMAIDMGLQ
 | |.. |||||||||||.. |.  . 
.kkpviahcsagvgrtgtlaliesmia
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 219-322 3.3e-25 83.5 In-house 38-153 (350) alignment 
Range on Protein: 219-322
Range on HMM: 38-153/350.0
EMTISVSQKNKPLNRFRNVLVYDDNRIILK--PLP----SHEGCQNDYINASFIDGY------SSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTN
.. .|   .    ||..|.| |. .|..||  . .     |    ||||||...          . ..|||||.|. .|. ||...| . | .||...|.
DvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

LMEGGRNKCHQYWPDS
..| ...||..||.. 
dvelnlekcyrYWqeg
0048179 (Phosphotyrosine protein) phosphatases II 323-450 5e-25 83.3 In-house 9-131 (144) alignment 
Range on Protein: 323-450
Range on HMM: 9-131/144.0
DSVYYGPFKvTLIDKQVLPDYTVRELQLILLGSDQPPLMIT--QYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTFMAIDMG
...|.|..  |..| . | .. .. .  .  . ... |  .  ||....|||||||.... .|.| . |.. ..  .||.|||||||||||||..|... 
pglylgslp.taldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylm

LqqaekEGGIDIISIINRMRQQRMFMVQTR
.     . |... ......|..|...|...
k.....klglsleealalvrsrrpgavpnp
subfamily_ptpA1_pd Subfamily ptpA1 473-686 5e-25 83.1 In-house 26-255 (418) alignment 
Range on Protein: 473-686
Range on HMM: 26-255/418.0
QFTVLEQVTqKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKeRKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQE
.| .||.    | | .     .|  ||| |. || .  || ||  |     .|||| |.|     | || .. |.  |. .||.|. .  .  |||| .|
efrlleesv.gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsre

KENDEEVCYKYWPTEA----------TEVIFGEYSIKLLnEELYDLYTE-RTIEIKNKMKGGSRhKVVQYQITGWePNGEVTCH-QAILMILEEMNKTQR
 ||    | .||| .            . .|| ||..|. | . |   |  | .|.  ..| .|  . |||  || |. ..  | | .  .|  . . | 
sencrikcdrywpeqiggeqfsiygngnevfgtysvelv.eviqdpereiitrnirltfegetr.ditqyqyegw.pdhnipdhtqpfrqllhsitnrqn

----R-SGNTSIVVHCSDTVGRSAMFCAAATTINK
        |  |.||||  |||.  ||.|   ..|
qiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 460-727 5.7e-24 79.4 In-house 14-287 (305) alignment 
Range on Protein: 460-727
Range on HMM: 14-287/305.0
EQDPETGQTGYNKQFTVLEQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQP-NYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDIN
..  | | .|  ..|. .... .  . .     .|...|||  .    || || |.|  | .|| | || .  . | || ...|.  |  .|| |  . .
krtlekgpaglraefvamkrfnd.fekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdk

VTAIVMLCQEKENDEEVCYKYWPTEATEVI-FGEY----SIKLLNEELYDLYTERTIEIKNK-----MKGGSRHKVVQYQITGWEPNGEVTCHQAILMIL
| || |||. .|   . |..|....  .|. | |     |.|.   . ... ..   ....        |.. .|| .|    |   |  .  .||| .|
veaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailell

EemnKTqrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
|   |.  |.    ||||||  .||.         ...  .  .|.   ..|.  | |.  |.|| .||  . ...  |.
e...ka..rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 232-449 1.8e-23 78.1 In-house 23-244 (290) alignment 
Range on Protein: 232-449
Range on HMM: 23-244/290.0
NRFRNVLVyDDNRIILKPLPSHegCQNDYINASFIDgYSSAYRYIATQGPMAN-------TLVDFWRLIWQEKPHVIVMVTNLMEGGRN----KCHQYWP
.| .. ||  ..|..||   ..   ..||| |...  ...  | |.|| | ..       |. .|| .. ||| . .||. . .|  .|     | .| |
qRlevpLv.eatrvvLkgygkr..fnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

DSD--SVYYGPFKVTLIDKQVLPDYTVRELQLILlgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAID
.|   .. .. ..|   .|    |  .||| .     |. .. .| . . .| .  |.|   ..|.  . .|..    | |..|||  |. |  .. ||.
esvgeelkfkgltvkCkskekeddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaii

MGLQQAE-KEGGIDIISIINRMRQQRMFMVQT
.| |    ..| . . .... .|.||  ....
lgyQkiaetsgsvkledvlkalrkqralaits
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 280-451 2.3e-23 77.1 In-house 98-275 (302) alignment 
Range on Protein: 280-451
Range on HMM: 98-275/302.0
GPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDS--DSVYYGPFKVTLID-KQVLPDYTVRE-LQLILL------GSDQPPLMITQYHFTS
 |  .||  .| || | .  ..| .....|.. .|| .|. |   . . .| . |. .. |. | ..| .. ..|  .        .. .  .   .|..
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPEYATSILQFHRRIkNEYKptkGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
||||| |. | . |.  .   . ||     .|||||||||||||..||  |.|   |.   |..||.  .|| |   ||.  
wpdhGapkeaytaldilkfc.esyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeq
0051082 (Phosphotyrosine protein) phosphatases II 519-718 3.5e-23 77.3 In-house 3-144 (151) alignment 
Range on Protein: 519-718
Range on HMM: 3-144/151.0
PNYINAVYVDSYkerkaFIIAESPmfstVRNFWKMIEDINVTAIVMLCQEKENDeeVCYKYWPTEAtevifgeysikllneelydlytertieiknkmkg
..|||. ||...     ...   |       |...... ....||.|..|.|..   |..|.| .                                   
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

gsrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKtqrrSGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVEQYKG
   ..|....|..| . |  .. .|.| .||....     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||. .|.  
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 492-723 4.2e-23 76.4 In-house 34-265 (281) alignment 
Range on Protein: 492-723
Range on HMM: 34-265/281.0
ASQNKDKNRSTQFLPPDNHRVVLKGQQPN-----YINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATE
   |. ||| ..    |  || || . ||     || | |. |   .. .|... |   |  .||.|| . | ||||||||  | . | | .|.| .|  
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

V-IFGEYSIKLLNEELYDLYTerTIEIKNKMKGGSRhKVVQYQITGWePNGEVTCHQAIlmILEEMNKTQRRSgnTSIVVHCSDTVGRSAMFCAAATTIN
.  | ..|..  .  .       |  ..   .| .|  . ..    | |. .|     .  .|. . | . ||  |  |.|||  ||||  . |   ...
clqfdklsvsyedstvnkslv..ttrlnlsyegetr.lithwlwkew.pdwqvpessev..mlkilrkirars..tppvihcsagvgrsgtlmaveialq

KCKTEG-VIDVFQVLKSQRIQ-KPGSVQTVEQYKGIFEIV
  ..   . |. |..   |.  .  ||||..||  |....
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 494-727 3e-22 74.0 In-house 42-271 (288) alignment 
Range on Protein: 494-727
Range on HMM: 42-271/288.0
QNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVI-FGEY
.|  ..| ..    |  || |.     ||.|  | | | .. .| |..|. .|. ..|||. . .|  |||||.  |   |   .|.|..  | . .| .
anptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

sIKLLNEELYDLYTERTIEIKNKMKGGSRHK-VVQYQITGWEPNGEVTCHQAILMILEEMnktqrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG
  .   ..  |.    .. . .  | |  .. | .  .  |. .|    ... | .|| .     .| .  ||||.|  |||.. .      ..  . . 
.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrldd

VIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
 . . ..|.. | ..  ..||  ||  .. .|  .|
flgirsllaklreerfkaiqtemqylyvhrcvleel
0044763 (Phosphotyrosine protein) phosphatases II 518-725 3.1e-22 74.5 In-house 17-169 (178) alignment 
Range on Protein: 518-725
Range on HMM: 17-169/178.0
QPNYINAVYVDSYkerkaFIIAESPMfstvRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATevifgeysikllneelydlytertieiknkmk
   ||||.... .     ....  |.     ...... . ..|.||.|..|.|.  . |..|||.||                                 
rsdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................

ggsrhkvVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrSGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVEQYK
       .||. .... .|. .  . .| ..| ... .  . .  ..||||  ||||....||   .      |. .......  | ..|  |.. .|..
.......iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlr

GIFEIVQI
 . |. ..
qLyefelr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 499-721 7.9e-22 72.7 In-house 23-253 (290) alignment 
Range on Protein: 499-721
Range on HMM: 23-253/290.0
NRSTQFLPPdNHRVVLKGQQ----PNYINAVYVdSYKERKAFIIAESPMF-------STVRNFWKMIEDINVTAIVMLCQEKENDEE----VCYKYWPTE
.| .  |   . ||||||       .|| | .| .. .  ..|. .||         ||. .|| |. . .|. .||||. .|....     | || |..
qRlevpLve.atrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

AT-EVIFGEYSIKLLNEELYDLYTERTIEIKnkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTqrrsgNTSIVVHCSDTVGRSAMFCAAAT
.  |. |.  ..|  . |  |   .|....|    ..  ..|  ... ||..      .. .| ... ...      .| ..||| | . |||.. |   
vgeelkfkgltvkCkskekeddvetRelvvk..fddeeeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiil

TINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
   |   |.| . . .|||. | |.   ... ...  .  
gyQkiaetsgsvkledvlkalrkqralaitsalelafvda
PTPc_DSPc_SM00012 623-721 9.5e-22 72.6 In-house 1-101 (105) alignment 
Range on Protein: 623-721
Range on HMM: 1-101/105.0
KVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
.| .|..|||   |  .  ..|| .|....| .. |. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| |||  . 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

E
.
r
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 484-723 6.7e-21 69.5 In-house 24-266 (285) alignment 
Range on Protein: 484-723
Range on HMM: 24-266/285.0
PDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVD-SYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT
| ..|.     | | || ..    .. ||||| .. .|| | ..    |.. ..| .. |.  |. .||.|| . ... ..|||   |   | |  |.| 
ppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

EATEVI-FGEYSIKLL--NEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNgEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCA
.  ||. ||.| | |   .||        .. . |     |    ...    | |. ...  .|  ||       .    .. |.||||  |||.| |  
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpd.qlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvg

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
   .  .   .  |.......  |  .  .||.  |.  .. ..
idyatirimenpniemldivremramrfqavqshmqflflyvvl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 492-726 2.9e-20 67.1 In-house 52-288 (305) alignment 
Range on Protein: 492-726
Range on HMM: 52-288/305.0
ASQNKDKNRSTQFLPPDNHRVVLKGQQP-NYINAVYVDSY-KERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIF
|  .. ||| ..    |.  | |.  .| .|| | ||       | || |. |.  |. .|| |. . .|  |||||.  |     | .|||.   |   
adiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

GEYSIK---LLNEELYDLYTERTIEIKNK-MKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMnktqrRSGNTSIVVHCSDTVGRSAMFCAAATTIN
    |    .      .  .|  | . |  . |. .  | . | | |   |   |. . | .|  .     |  .  ||||||  .||.    |    ..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai.....rgskvpivvhcsagigrtgtivaieyile

KCKTE-GVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
|   .  .  . ...|. | |.  |.|.  ||  |  ..  |
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_egg_pd Subfamily egg 469-727 8.3e-20 65.7 In-house 15-270 (307) alignment 
Range on Protein: 469-727
Range on HMM: 15-270/307.0
GYNKQFTVLEQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVM
...... |||.....   .|. ... |..| || .    |  || |. ..     ..| | .|.       ||.|..|.  || .||.|.   .|  |||
elerrlevleesvde.islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

LCQEKENdeEVCYKYWPTEATE-VIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRH-KVVQYQITGWEPNGEVTCHQAILmileemNKTqrRSGNTS
|   ||.  | |  |||   .. ...   |... | ....         | |. || .  . ...    ..  ..|     .|       |   |   . 
ltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvl......rkl..rnlskp

IVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVEQYKGIFEIVQIYL
.||.. . | ..| . |. ... .    | |  . ||..    | ... ||..| .|  .. .| ...
vvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 285-449 5.1e-19 63.3 In-house 40-206 (255) alignment 
Range on Protein: 285-449
Range on HMM: 40-206/255.0
TLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLIL-LGSDQPPLMITQYHFTSWPDHGVPEYATSIL
|.  |.. | | |..|.||.... | |..||..|.|          .|...  .   |  .| |.... ||  .    .. |... |...  || |  ||
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

QFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMFMVQT
.  . ...  |    ...||||.|.||. .|. ...  |      .  . ...| .|... .|..|   ..|
nilkvvrds.k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraiht
subfamily_CG42327_pd Subfamily CG42327 474-653 8.3e-19 62.4 In-house 11-192 (319) alignment 
Range on Protein: 474-653
Range on HMM: 11-192/319.0
FTVLEQVTQKPDevthNIASQNKDKNRSTQFLPPDNHRVVLKGQ----QPNYINAVYVDSYKERKA-FIIAESPMFSTVRNFWKMIEDINVTAIVMLCQE
|  | |.  . |    ..    |||.|  . .|  . ||||. .    . .|..| ||  |.. .. .| |. .. ..  .||... . .   || |.. 
frdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdl

KENDEEVCYKYWPTEAT---EVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQItGWEPNGEVTCHQAILMILEEMNK
 |.  .|| .|.||..|   .  .|.. . | . |  | |   |. .|.  |  || ..  |    |   .  . ..|.. .| |...
selGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesr.elthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 540-717 1.7e-18 61.1 In-house 97-278 (302) alignment 
Range on Protein: 540-717
Range on HMM: 97-278/302.0
ESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEV-IFGEYSIKLL--NEELYDLY-----TERTIEIKNKMKGGSRHKVVQ-YQIT
  |  ||.  .| .||. ||. .| ||. .|..|. | .|. ..  ..  ||.|..| .  ...| ..      .  |.||||. |    .| |.  . .
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

GWEPNGEVTCHQAILMILEEMNktqrrSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYK
.|   |     .. | ||   .     |  ....||||  |||.  . |    |. |... | |. ....  |  . |.||. .|  
awpdhGapkeaytaldilkfce.....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 494-734 8.3e-18 59.1 In-house 42-283 (312) alignment 
Range on Protein: 494-734
Range on HMM: 42-283/312.0
QNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATE------V
. || ||  .    |  |  | |..  || | .|      . |.....|. .|. .||..   .  |.|..||   |.  | | ||     .        
kfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

IFGEYSIKL-LNEELYDLYTERTIEIKNKMKgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrsgntSIVVHCSDTVGRSAMFCAAA---TT
.. ||  .. .     |  | | . .  |   |   |. .|| . |   |     .. | .|  ..| ..      .. |||  |||.  ..      ..
vyteycteieiggkskdkithrvlkvvvkat.gqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaa

INKCKTEGVIDVFQVLKSQRIQkpgSVQTVEQYKGIFEIVQIYLDSFMLYS
. . . . | |.| .|. .| .   ||... ||   . .|  .| |  || 
lrhprkqnvkdsfvllrkdrar...svrvfpqyvyalrcvleflyskglyk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 531-721 1.5e-17 58.4 In-house 2-198 (199) alignment 
Range on Protein: 531-721
Range on HMM: 2-198/199.0
KERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT-EATEVIFGEYSIKLLNEELYDLYTERTI-EIKNKMKGGSRHKVVQYQ
| .. .| .. |.  |. .||.|. .     |||. ... | |     |||| |..   .|  |.          ||  ..   .|     |  .. .||
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

ITGWEPN--GEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
.| |  .   .|.    ...   |. |   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . ....|. |..
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 491-727 1.7e-17 57.8 In-house 47-285 (302) alignment 
Range on Protein: 491-727
Range on HMM: 47-285/302.0
IASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTV---RNFWKMIEDINVTAIVMLCQEKENDEeVCYKYWPTEATEv
.  .| .||.|...  .|...| |.... .|.||  |.  . ..  |.|  |  ...    .||.|. . ... .|.| .|.| ..    ...|... . 
afkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd.

iFGEYSIKLLNEELYDLYT----ERTIEIKNKMKGGSRHKVVqYQITGWEPNGEVTCHQAILMILEEMnKTQRRSGNTSIVVHCSDTVGRSAMFCAAATT
 . ||    .|    .       . .||.  .    |    | | .| |...   .   ..    ...  ..  ... ..|.     .|| ..| ..|..
.ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanv.yvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlava

INKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
..| ...    . ...|| | |.| .|....||  .. .. .|.
veklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 482-706 2e-17 58.1 In-house 16-200 (255) alignment 
Range on Protein: 482-706
Range on HMM: 16-200/255.0
QKPDEVTHNIASQNKDKNRSTQFLppdnhrvvlkgqqpnyinavyvdsykerkafiiaespmfsTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWP
.  |. |.... ... |..... |                                        || .|...|   . . .||||  .|.. | | .|.|
idedvctehvkPekdkkrknlysl........................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfp

TEATE-VIFGEYSIKLLNeELYDLyTERTIEIKNKMK-GGSRHKVVQYQITGWEPNGEVTCHQAILMILeemnKTQRRSgnTSIVVHCSDTVGRSAMFCA
.|  |  .. . ..   .    |    ||.||  ..      |.|  |. .||  .      . || ||    |  | |   |.|||||  .|||| |  
lekdeklkladvnvtttk.ssadv.vlrtleitstlgekkkthtvkhysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvl

AATTIN-------KCKTeGVIDVFQVLKSQRIQK
|            . .| . .|  ..|.  | ..
aelvyqkmirsldttet.veldylslleelrskr
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 533-721 2e-17 58.0 In-house 3-197 (198) alignment 
Range on Protein: 533-721
Range on HMM: 3-197/198.0
RKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT-EATEVIFGEYSIKLLNEELYDLYTERTI-EIKNKMKGGSRHKVVQYQIT
.. .| .. |.  |. .||.|. .     |||. ... | |     |||| |..   .|  |.          ||  ..   .|     |  .. .||.|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

GWEPN--GEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
 |  .   .|.    ...   |. |   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . ....|. |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 202-449 2.6e-17 57.2 In-house 30-270 (302) alignment 
Range on Protein: 202-449
Range on HMM: 30-270/302.0
EEFmKQYALFHNDLDKhemtISVSQKNKPLNRFRNVLVYDDNRIILkplpshEGCQNDYINASFIDGYSSAYRYIATQGPMANTL---VDFWRLIWQEKP
.|| |. . .  ||.|     .. .||   |.  .| ..|.|...|      |.....|.||| ..  .  .  | .| |  ..     .|||...||| 
kef.kkidtmkvdlek....Ckafkknlkknqsedvpildsnlvkl......eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

HVIVMVTNLMEGGRnKCHQYWP--DSDSVYYGPFKVTLidKQVLP--DYTvRELQLILLGSDQ-PPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
  .|..    |  .   ....|    | ..|| . |    ..|    . .  .. . .|  .    .... |..| |... ||.  ... .    . .. 
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNn..rkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakk

KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQT
 ... ....    |.|| |.|..  . ... .|.    |  |.. .|.||  .|..
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravds
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 494-633 4.6e-17 56.8 In-house 32-175 (297) alignment 
Range on Protein: 494-633
Range on HMM: 32-175/297.0
QNKDKNRSTQFLPPDNHRVVLKGQQP--NYINAVYVDSYKERK--AFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVI-
    ||| .. |  |. || |..  .  .|||| ||   .| .   .|.|. |. .|| .||... . .| .|||... .|.  . |. |||    |   
sslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlk

FGEYSIKLLNEELYDLYTERTIEIKNKMKgGSRHKVVQYQITGWE
 |.. .. | .   .  .    |..   .   . .|   |  .| 
agdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswp
subfamily_hpo-7_pd Subfamily hpo-7 531-711 5.3e-17 56.6 In-house 42-211 (263) alignment 
Range on Protein: 531-711
Range on HMM: 42-211/263.0
KerkafiiaespMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATE-VIFGEYSIKLLNEELyDLyTERTIEIKNKMK-GGSRHKVVQYQ
            .  |. .|...|.  . . .||||  .|.. | | .|.|.|  |  .. . ..   .    |.   .|.|. . ..     |.| .|.
l...........lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dv.llktlellstlgeKkkthtvkhys

ITGWEPNGEVTCHQAILMILeemnKTQRRSgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQ
 .||  . ...  . || ||    |  | |   |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......
ykgWiekndpelareilnil....kvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraih
subfamily_hpo-7_pd Subfamily hpo-7 284-449 6.6e-17 56.3 In-house 45-212 (263) alignment 
Range on Protein: 284-449
Range on HMM: 45-212/263.0
NTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLIL-LGSDQPPLMITQYHFTSWPDHGVPEYATSI
.|.  |.. | | |..|.||...  | |..|| .|.|          .|..   .|  |  .. |.|.  ||  .    ...| .. |...  || | .|
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMFMVQT
|.  .  .|  |    .. ||||.|.||.  |  ...  |      .  . ...| .|... .|..|   ..|
lnilkvarns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 466-590 3.1e-16 53.8 In-house 25-150 (310) alignment 
Range on Protein: 466-590
Range on HMM: 25-150/310.0
GQTGYNKQFTVLEqvTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK---GQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAI
|  |  ||.  |.  ...   .|..   ..  ||| .. .  |. || ||    .  .|| | || .   |..|| .. |.  |. .||.|| .    .|
gieglvkqyrkld..akqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesi

VMLCQEKENDEEVCYKYWPTEATEVIFG
..||.  |.    |  |||.      .|
lllckvgeegrpkcvgywpslgvtetyg
I-set Immunoglobulin I-set domain 77-162 4.1e-16 50.5 Pfam-A 2-90 (90) alignment 
Range on Protein: 77-162
Range on HMM: 2-90/90.0
FIEEFPNNLTAEVGQEVHFKVKFKGTPTPSFNWYHNGEPVTDDYAHEIKGDG---SLLLVSVEKIHKGVYGFVANNDAGTVSQQVVLTV
 ... ........|..| .... .|.|.||..|...|.... .  .... ..   .| . .||.  .| |  .|.| ||...... |.|
kftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 621-723 5.4e-15 49.6 In-house 88-190 (440) alignment 
Range on Protein: 621-723
Range on HMM: 88-190/440.0
RHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
 . . ||.  ||  .|       .| .....|..| ..||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| |||  ..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

EIV
| |
eav
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 221-374 7e-15 49.3 In-house 89-234 (244) alignment 
Range on Protein: 221-374
Range on HMM: 89-234/244.0
TISVSQKNKPLNRFRNVLVYDDNRIILkplpSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEkpHVIVMVTNlmeGGRNKCHQYWP
  ... .|   ||    | .| ||. |    |.    | ||||||.     .  || || |.|.| .|||... .   || |.|     |  ..  .|||
kdafnpnnswknregaglpfdfnrvpl....skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmler..hvnvlvvl...gsveeedeywp

DSDSV--YYGPFKVTLIDKQVLPDYTVRELQLIlLGSDQPPLMITQYHFTSWPDHG
||. .  |     ||| |.. . .    .|..     ..    .| .  . ||  |
dseplewyeeditvtltdrdefknikasnleie.sdmneshqaltmfqisnwpsdg
0048076 (Phosphotyrosine protein) phosphatases II 600-726 2.7e-14 48.5 In-house 24-142 (145) alignment 
Range on Protein: 600-726
Range on HMM: 24-142/145.0
ELYDLYTERTIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRsgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVL
.| ||   . . . .  .. . ....||. ..|. .|. . .. .| .|| ... ...  .  ..||||  |||.....||   .     .| ......|
llkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleeal

KSQRIQKPGSVQTVEQYKGIFEIVQIY
.  | | ||.|....|.. ..| ....
elvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 551-719 4.1e-14 48.0 In-house 22-137 (144) alignment 
Range on Protein: 551-719
Range on HMM: 22-137/144.0
WKMIEDINVTAIVMLCQEKENDEEVCYkywpteatevifgeysikllneelydlytertieiknkmkggsrhkVVQYQITGWEPNGEVTCHQAILMILEE
.... . ..|... |. | |.... ..                                              ..||. ..|. .|  .  . .| .|| 
lellkklgittvinlteeyepeflere..............................................giqylhlpwpDhgvpdllellleflef

MNKTQRrsGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVEQYKGI
... ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|.. .|.. .
ieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfL
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 219-322 4.2e-14 46.6 In-house 41-156 (349) alignment 
Range on Protein: 219-322
Range on HMM: 41-156/349.0
EMTISVSQKNKplNRFRNVLVYDDNRIILKPLP------------SHEGCQNDYINASFID--GYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMV
...  |    |  ||....| |.  |..||  .            |. |  .||||| ..    .|   .||||| |.  |. ||...|  .. .... .
ilseGvelfak..nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL

TNLMEGGRNKCHQYWPDS
..  | . .||..|| . 
nddkelslekcdiywqel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 485-585 2.3e-13 44.6 In-house 38-155 (350) alignment 
Range on Protein: 485-585
Range on HMM: 38-155/350.0
D-EVTHNIasQNKDKNRSTQFLPPDNHRVVLK-GQ-----------QPNYINAVYVDSY----KERKAF--IIAESPMFSTVRNFWKMIEDINVTAIVML
| .... .  .   ||| .. || .  || || .              .|||| |.       .    |  | . .|. ||| .|.|.|   .|. |..|
DvilseGv..elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

CQEKENDEEVCYKYWPTEAT
 .. |.. | ||.||.  . 
tsdvelnlekcyrYWqegsy
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 184-280 6.8e-13 42.6 In-house 5-95 (95) alignment 
Range on Protein: 184-280
Range on HMM: 5-95/95.0
IPVGKFGEFVADGHANNDEEFMKQYALFHNDlDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpshEGCQNDYINASFIDGYSSAYRYIATQG
| |  |   | . |.| |.|| ...            |.  |. | | ||| |.. ||  |..|         . ||||| |.|||.    |||.||
ihvsvfhshvlemhsnsdqefdnefksismt.sgapytvgsseanipknrflnifpydatrvvlt.....tkrdsdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 482-639 8.3e-13 42.5 In-house 83-237 (244) alignment 
Range on Protein: 482-639
Range on HMM: 83-237/244.0
QKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVL-KGQQPN-YINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEevcykY
  |  .   .  .|  |||    || |  || | ||   | |||| .|        .|... |.  |  .||||. .  |  .|.|   .|.||     |
pdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....y

WPT-EATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVT
||  |  |    . .. | . . .       .||.  |.  |   .  .||. |  .|   
wpdseplewyeeditvtltdrdefknikasnleiesdmne.shqaltmfqisnwpsdgttp
subfamily_CG42327_pd Subfamily CG42327 394-450 2.5e-12 41.1 In-house 244-301 (319) alignment 
Range on Protein: 394-450
Range on HMM: 244-301/319.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMFMVQTR
.  .||. |||| ||||||. .| |. ... |.    .||  ..  .|..|   |.|.
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 359-451 8.8e-12 39.4 In-house 214-331 (350) alignment 
Range on Protein: 359-451
Range on HMM: 214-331/350.0
PLMITQYHFTSWPDHGVPEYATSILQFHR--------RI-KNEYKPT-KGPMLVHCSAGVGRTGTFMAIDMGLQQA-------EK-------EGGIDII-
|... | ..  |.| ..     ||||            . .. ..     |.|||||||||||||....|. |..        ..           |.| 
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

SIINRMRQQRMFMVQTRA
 |.|..|.||. |||.  
iivnelrkqrismvqnld
subfamily_eak_pd Subfamily eak 501-649 1.2e-11 38.6 In-house 57-205 (332) alignment 
Range on Protein: 501-649
Range on HMM: 57-205/332.0
STQFLPPDNHRVVLKGQQPN---YINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEA-TEVIFGEYSIKL
  . .| | . | |   | |   ||||  ..  .  . .|..  .  . |  ||.|. . .  |||.| .. |.. |   ||.| ..  |. || . .. 
vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver

LNEELYDLYTERTIEIKnkmKGGSRHKVVQYQITGWEPNgEVTCHQAILMILE
 .    . .  | .|..   ||   |.|  |.. ||    ..   .  | . .
kefvkrniletrllels...kGnethrvlhykvfGwtet.tlpkyedflalrk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 267-349 1.7e-11 38.1 In-house 230-310 (440) alignment 
Range on Protein: 267-349
Range on HMM: 230-310/440.0
DGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEggrNKCHQYWP-DSDSVYYGPFKVTLIDKQVLPDYTVRELQ
.|||    .|||| |.  |..|||||. . .   |.|. .| .   . |  ||| .. || .||| |     . .    || |.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtle
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 204-450 4e-11 37.1 In-house 28-265 (303) alignment 
Range on Protein: 204-450
Range on HMM: 28-265/303.0
FMKQYALFHNDLDKHEMtisVsqKNKPLNRFRNVLVYDDNRIILkplpshegCQNDYINASFIDgYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVM
| |  . .  .. |...   |  ||   ||| .|.. |  .. |        ..  || ||...   |  . | || |.. |  |||..| ..| .....
fekvvsylppsvsknqf...v..knmdknrfvdvicldhskvkl........sdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvll

VTNLMEGGRNKCHQYWPDS-DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPE-----YATSILQFHRRIKnEYKPTK
.    |  .   .  .|   | . .    . . . . .       |... .   .   ..  .|. .||   .|      .   | |    ..  | ...
lltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlr.kysdst

GPMLVHCsAGVGRTGTFMAIDMG-LQQAEKEGGIDIISIINRMRQQRMFMVQTR
 .. .   .|.||.|||  ..   |   ...  .|..  .. .|. |.  ||  
ptvymsl.sgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnl
subfamily_eak_pd Subfamily eak 213-387 5.6e-11 36.4 In-house 33-205 (332) alignment 
Range on Protein: 213-387
Range on HMM: 33-205/332.0
NDLDKHE--MTISVSQKNKPLNRfrNVLVYDDNRIILKPLPSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEG
.|||...  ..||.... . .||  ||.    .   |  | |    .. ||||| ..      .|| |  .  . .  ||... ..|   ||.. . .| 
adlddyqrllsisetarleavnr..nvvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvel

GRNKCHQYWPDSD--SVYYGPFKVTLIDKQVLPDYTVRELqliLLGSDQPPLMITQYHFTSWPDHGVPEYAtSILQFHR
. .|  .|.||     . .| ..|.  .      . .| |    |        .  |..  | .  .| |    | ...
kleksdkyfpdktreelkfGildverkefvkrniletrll...elskGnethrvlhykvfGwtettlpkye.dflalrk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 496-602 1.3e-10 35.1 In-house 85-171 (349) alignment 
Range on Protein: 496-602
Range on HMM: 85-171/349.0
KdknrstqflppdnhrvvlKGQQPNYINAVYVD--SYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWpteaTEVIFGEYS
.                   |.  .|||| |.    ..  | .|    |. ||| .|.|.|   .|  .. | ..||.. | |..||     |  . .. 
d..................sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw....qelsysnit

IKLLNEELY
.|| |  ||
vklqnssly
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 478-722 1.7e-10 35.0 In-house 29-274 (303) alignment 
Range on Protein: 478-722
Range on HMM: 29-274/303.0
EQV-TQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKgqQPNYINAVYVDSYKERKAfIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVC
|.| .  | .|..|   .| |||| .. .  |  .| |   .  || | |..   ..|| |... |.  |  .||.|| . .|  ...|  . | |.   
ekvvsylppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklgg

YKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWePNGEVTCH---QAILMILeEMNKTQRR-SGNTSIVVHCSDTVG
   .| .   . | | ||.. .    .|    .. .    .|  .  .  ..   | | ... ..   . .  |  ...   |. | .|  |      .|
dsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykaw.phnsipsdgspkfvkqiw.qlqsvlrkysdstptvymslsgcg

RSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEI
|.  |.   |.     . .  .|. ..|.  |  .  .|| . |.  .. .
ragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 219-304 1.9e-10 34.8 In-house 28-116 (347) alignment 
Range on Protein: 219-304
Range on HMM: 28-116/347.0
EMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCQN---DYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMV
..| .  .|.   || ..| . |. |..| |  |. .  .    ||||| |    .   || || |. .|. |||...   |   .| .
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 227-314 3e-10 34.1 In-house 33-117 (332) alignment 
Range on Protein: 227-314
Range on HMM: 33-117/332.0
KNKPLNRFRNVLVYDDNRIILKPlpshEGCQNDYINASFIDGYSSAYRYIATQGPMAN-TLVDFWRLIWQEKPHVIVMVTNLMEGGRNK
.|  .||   . ..| .|. | |    .  ..|. |||..||||    || .| |. . |   |||.. . || .|... .. |  . |
nnmdmnriphlycfdhsrvelap....qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 240-338 3.3e-10 34.4 In-house 5-90 (130) alignment 
Range on Protein: 240-338
Range on HMM: 5-90/130.0
YDDNRIIlkplpshegcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVtnlmeGGRNKCHQYWPDSDSVY--YGPFKVTLIDK
.. .|.           .|.||||||.     .  |. || |.|.| .|||... .    |.|..     |  ..  .|||||. .        ||| |.
fevsrlq..........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl.....gsveeedeywpdsePlewyeediivtltdr

Q
.
d
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 483-573 4.5e-10 33.6 In-house 25-123 (347) alignment 
Range on Protein: 483-573
Range on HMM: 25-123/347.0
KPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK---------GQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCqEKENDE
 | ..| .   .. .|||| .    |. ||||           .  .|||| ..   . .| .|... |. .|||.||||.  ..|| .| .  |  .||
spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif.epikde
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 400-449 1.4e-09 32.2 In-house 1-50 (69) alignment 
Range on Protein: 400-449
Range on HMM: 1-50/69.0
MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQT
|.||||.| ||||||.|| . . .   |  .||   .. ||. |  ||  
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmn
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 647-723 2e-09 31.8 In-house 217-291 (297) alignment 
Range on Protein: 647-723
Range on HMM: 217-291/297.0
ILEEMNKTQRRsgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
 || ..  . |  |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.||.. ....|
qleslraempr..nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 402-451 2.6e-09 31.3 In-house 2-51 (69) alignment 
Range on Protein: 402-451
Range on HMM: 2-51/69.0
VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
||||.| ||||||.|| . . .   |  .||   .. ||. |  ||    
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmnen
subfamily_CG42327_pd Subfamily CG42327 654-726 3.3e-09 30.8 In-house 241-314 (319) alignment 
Range on Protein: 654-726
Range on HMM: 241-314/319.0
TQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
. .|. .  .|||||| |||. .  |.  .|.. ..    .|. |.. | | ..  .|.|.|||. |. ... |
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 394-450 3.8e-09 30.8 In-house 225-281 (297) alignment 
Range on Protein: 394-450
Range on HMM: 225-281/297.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.| . ..||||||||||.|  .  |. |..  |.   |. .|.. .|.||  .||| 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 357-449 1e-08 28.9 In-house 215-329 (349) alignment 
Range on Protein: 357-449
Range on HMM: 215-329/349.0
QPPLMITQYHFTSWPDHGVPEYATSILQFHRrIKNE----------YK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQ---QAEKE--------GGIDIIS
. | .. |  .  |.| ..     ||||    .||.          ..     ..||||||| ||||... .|. |.     ..|           |.||
ekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

-IINRMRQQRMFMVQT
 |.| .|.||. ||| 
iivnelrkqrismvqn
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 517-637 3.2e-08 28.0 In-house 11-126 (130) alignment 
Range on Protein: 517-637
Range on HMM: 11-126/130.0
QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEevcykYWPT-EATEVIFGEYSIKLLNEELYDLYTERTIEIKNK
|. .|||| .|      . .. .. |.  |  .||||. .  |  .|.|   .|.||     |||  |  |    .  . | . . ..      .||...
qgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikasnleiesd

MKGgSRHKVVQYQITGWEPNGE
..  | . .  .||. |  .| 
lne.shqaltmfqisnwpsdgt
0038934 (Phosphotyrosine protein) phosphatases II 364-417 7.8e-08 27.7 In-house 81-135 (194) alignment 
Range on Protein: 364-417
Range on HMM: 81-135/194.0
QYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAI
.|.   .||.|..     .|.| . ..  ..  ..|  .||| ||.|||||. | 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 188-271 8.3e-08 26.0 In-house 10-88 (440) alignment 
Range on Protein: 188-271
Range on HMM: 10-88/440.0
KFGEFVADGHanNDEEFMKQYALFHNDLDKHEMTISVsQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSS
 | ..| . .      |  ...|. . | .     |.  .||  ||.||.|.|| .|..|. .  .   ..||||||.|.|  |
dfadyvqnnr..rsrafedewsllpsglsqpsdiasl.pnnkvknryrnilaydhsrvmleev..kgvpdsdyinasyingies
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 526-727 4e-07 23.0 In-house 107-309 (346) alignment 
Range on Protein: 526-727
Range on HMM: 107-309/346.0
YVDSYKERKAFIIAESPMF---STVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRH
|.  ..  . .|.|. | .   | | .|| || . ..  . ..  .    .     .   .      |   |.    ..     | |||.  . .  |  
yfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvi

KVVQYqITGWEPNGEVTCHQAILMILEEMNkTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEI
  |..  . |    .      |. .. ..  ....  |. . |      ||.  |  |  .||.       ......|. . |.||.|..  || .|. |
cqvhh.hapwkhlqqppktlpiikmihqfl.sekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai

VQIYL
|  |.
vfdyi
PTEN_1 364-414 1.8e-06 22.9 In-house 96-147 (196) alignment 
Range on Protein: 364-414
Range on HMM: 96-147/196.0
QYHFTSWPDHGVPEYAtSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTF
.|.  ...|||.|  . ... . ..... ..  | ..  |||| ||.||.|| 
eylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtv
subfamily_PTPDC1_pd Subfamily PTPDC1 365-451 3.2e-06 21.7 In-house 85-163 (182) alignment 
Range on Protein: 365-451
Range on HMM: 85-163/182.0
YHFTSWPDHGVPEYaTSILQFHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAekeggIDIISIINRMRQQRMFMVQTRA
..  .|.|.||.   ..||.  . ..   .  .| . ||| || ||||  .|  .  ..      ..    |. .|..|   .||| 
vynfgwkDygvasl.eriLdivkvvafalq..egkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtre
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 508-586 3.2e-06 18.9 In-house 57-136 (327) alignment 
Range on Protein: 508-586
Range on HMM: 57-136/327.0
DNHRVVLKGQQPNYINAVYVDsyKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEK---ENDEEVCYKYWPTEATE
 . | || | . ...   ||    |   .|| ..|   . .  |..|    .  .| ||...     |.  || |.|||  .
rdnrrvlcgsdeeffpgqyvr..megaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleq
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 491-540 3.4e-06 21.1 In-house 44-94 (95) alignment 
Range on Protein: 491-540
Range on HMM: 44-94/95.0
IASQNKDKNRSTQFLPPDNHRVVLKGQ-QPNYINAVYVDSYKERKAFIIAE
 .  |  |||  . .| |  ||||  . . .||||..|| |  ....| |.
sseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 493-567 8.6e-06 19.4 In-house 32-109 (332) alignment 
Range on Protein: 493-567
Range on HMM: 32-109/332.0
SQNKDKNRSTQFLPPDNHRVVLKGQQ--PNYINAVYVDSYKERKAFIIAESPMFS-TVRNFWKMIEDINVTAIVMLCQ
 .| | ||  ..   |  || |  |.   .. || .|| | .. |.|.|..|.   |   ||.|. . . . |... .
lnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd