Gene PTPRD-20 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP141_AA protein Get Run
AqueP141_AA_186-451 phosphatase_domain Get Run
AqueP141_AA_457-728 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 454-736 7.3e-149 489.4 In-house 6-287 (287) alignment
Range on Protein: 454-736
Range on HMM: 6-287/287.0
MIGKLSEQDPETGQTGYNKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKM
..|.........|..|...||||||||||..||||||||||||||||.||.|.|||.||.|||..|.|||||..|.|||.|||||||||||.|.|||||.
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkl

IEDINVTAIVMLCQEKENDEEVCYKYWPTEATeVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNK
|.| ||||||||||||||||||||.|||.|.. |..|||.|.||||| .. |.||..|.|||.| |....|.||||| |. .|.||..|.||...|||.|
iddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk

TQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYSNF
|||..|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|..||..|||||..||.|
tqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 183-452 4e-123 405.0 In-house 1-266 (287) alignment
Range on Protein: 183-452
Range on HMM: 1-266/287.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHN-DLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFIDGYSSAYRYIATQGP
||||.|||||||.|||...|.|..|...... . ...|.|......||..||....||.|..|..||      |...|||||.|||||......|....|
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

MANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHG-VPEYAT
|.||...||.||.......|||.....|  ...|.||||...||..|.....|....|  .|..|.|...  ..........||..|.|...| |.|..|
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt

SILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
..|......|...|.......||||..|||...|.|..........||.||........|.|.. .||| ..
illvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveq

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 460-734 5.3e-116 381.5 In-house 12-290 (290) alignment
Range on Protein: 460-734
Range on HMM: 12-290/290.0
EQDPETGQTGYNKQFTVLEQvTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK---GQ---QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKM
...  .|..|...||..|.. .... .||....|.|| .||.......|..|..|.   |.   . .||||.|.. |||.|..|....|...|...|||.
anghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

IEDINVTAIVMLCQEKENDEEVCYKYWPTEATEViFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNK
| . .||.||||....|.....|..|||.. |.  .||.|||||||| .. |.||..|.||| ..|....|.||||| |...|.||..|.||...|||.|
iwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

TQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
|||..|||||||||||||||||.|||||||||||||||||||||||||||||||||||||.||.|||.||  |||||. ||
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfetys

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 183-451 4.6e-112 368.6 In-house 1-270 (290) alignment
Range on Protein: 183-451
Range on HMM: 1-270/290.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCQNDYINASFIDGYSSAYRYIATQGPM
||||.||||||| |||...| | .|.  ...   .|..|. ....||.||||.|..|||||||.|.|...|. |.|.||||..|.||. ...|||||||.
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

ANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHG-VPEYATS
 |||||||.||||||  .|||.|| .| |..||.|||||||.  ||.|...|.. ..| .|. |.|..    |.... ..|||..|.|...| |....|.
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
.|......|...|.......||||..|||...|.|..........||.||........|.|.. .|||  
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvq

subfamily_PTPRD_pd Subfamily PTPRD 183-450 8.2e-106 349.9 In-house 4-267 (564) alignment
Range on Protein: 183-450
Range on HMM: 4-267/564.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHNDlDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCqnDYINASFIDGYSSAYRYIATQGPM
 ||| .. |.||  .||.| .|...|  ...  ...... .  . ||. ||. |.. || .|..|.... .||.  ||||||||||| .   |||||||.
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegs..DYINAsfidgyrkrkayIAtqgPl

ANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLiLLGSDQPPLMITQYHFTSWPDHGVPEYATSI
|.|. ||||..|... ..|||.|.| | |..|||.|||....  || ..||| ... | ||..|...|    ...   ...|.||||||||||||.|||.
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatsl

LQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
|.. |....  .|..||..|||||||||||||..||. |.....|. .|| ......|.|| .||||.
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqte

0051299 (Phosphotyrosine protein) phosphatases II 183-450 1.5e-95 315.3 In-house 4-272 (288) alignment
Range on Protein: 183-450
Range on HMM: 4-272/288.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPM
 |.| .. ..|   .||.   .....  . . | ........ ..|.. ||....| ||..|..|..|...||  .||||||.|||| .  ..||||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgveg..sdYinAsyidgynlkrkfIatqgPl

ANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLG---SDQPPLMITQYHFTSWPDHGVPEYA
 ||. ||||..|... .||||.|.|.| ||.||.||||...|..||...|||.. .||.|||||.|..  |.    |. ....|..|.|.|||||||...
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
...|.| |.... .....||..||||||||||||| |.|. |.| |||||.|. ....|.|.||..|||| 
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 183-452 2.6e-95 314.1 In-house 3-271 (305) alignment
Range on Protein: 183-452
Range on HMM: 3-271/305.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHNDldKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPM
 | . .. ... . ....|... .|| .. ..  .. . .  ...||  ||.... ..||.||||.. .|..  ..||||||..|||..  .||..|||.
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaqgPl

ANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSV--YYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYAT
 ||..||||||..||...|||.|.|.|||..||.||||.| .    .|.|.|.| ...  .||. |.|..    .|.    ..||..|.|||||||..||
kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

SILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
|.|.. .|.....|  || |.||||||||||||.|.|.|. |....||. .|.  .....|..|| |||| ..
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldq

0050432 (Phosphotyrosine protein) phosphatases II 198-450 4e-93 307.4 In-house 38-285 (308) alignment
Range on Protein: 198-450
Range on HMM: 38-285/308.0
ANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILkplpsheGCQNDYINASFIDGY--SSAYRYIATQGPMANTLVDFWRLIWQ
|..   .....  . .  . .|....  ..||..||....| || .|..|       .  .||||||..|||   .  ..||||||. ||. ||||..|.
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

EKPHVIVMVTNLMEGGRNKCHQYWPDS---DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
.. .||||.|.|.| ||.||.||||..   .|..||.|.|||.. .||.|||||.|.|  ||...  ...|..|.|.|||||||......|.| ..... 
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrks

YkpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.   .||..||||||||||||| |.|. |.| |||||.|. ......|.||..|||| 
l..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

0040438 (Phosphotyrosine protein) phosphatases II 187-450 4.6e-92 304.0 In-house 3-262 (317) alignment
Range on Protein: 187-450
Range on HMM: 3-262/317.0
GKFGEFVADGHANNDEEFMKQYALFHNDLDKhEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMANTL
 .. ... | ....   .....  . .     .....  ..||..||....| ||..|..|.||.....  .||||||..||..   ..||||||. ||.
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdld..sdYInAsyvdgpnlkrkfIatqgPlpntv

VDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFH
 ||||..|... .||||.|.|.| ||.||.||||. ....||.|.|||.. ..|...|.|.|..  |  |......|..|.|.|||||||.. ...|.| 
edFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfl

RRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
..... ... .||.|||||||||||||| |... |.| |||||.|. ......|.||. .||| 
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp

subfamily_PTPRB_pd Subfamily PTPRB 182-452 5.6e-91 299.6 In-house 5-273 (293) alignment
Range on Protein: 182-452
Range on HMM: 5-273/293.0
NLIPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGP
. | . || |.|.. .|..| .|...|  ...   ....... ...|.  ||..|.| || .|. |..| ...  ..|||||..|.||.|   .||||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdes..gsDYinanyipgynsprefiatqGP

MANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDS-DSVYYGPFKVTLIDKQVLPDYTVRELQLILlgsDQPPLMITQYHFTSWPDHGVPEYAT
. .|. ||||..|..| ..|||.|.|.|.|. ||..|||.  ..|.||  ||||. ...| |...|||..     ..    ..|||||||||||||| ..
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektk

SILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
..|.| |.....   . .|.|..|||||||||||||.|.|. ||. |.|  .||..|. ..|..|...||| ..
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq

0046845 (Phosphotyrosine protein) phosphatases II 205-450 7.7e-90 296.4 In-house 3-260 (284) alignment
Range on Protein: 205-450
Range on HMM: 3-260/284.0
MKQYALFHNDLDK--HEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHeGCQNDYINASFIDGY-----SSAYRYIATQGPMANTLVDFWRLIWQEK
....    .   |  ....... ..|. .||....|.||..|..||.|...    .||||||..|||      .  ..||||||. ||. ||||..|...
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

PHVIVMVTNLMEGGRNKCHQYWPDSD-SVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--
 .||||.|.|.| ||.||.||||... ...||.|.|||....| .|||||.|.|  || .......|..|.|||||||||......|.| | ... ..  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEG---GIDIISIINRMRQQRMFMVQTR
|..||..||||||||||||| |.|. |.| ||||   |.|. ....|.|.||..|||| 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl

0036941 (Phosphotyrosine protein) phosphatases II 202-450 8.5e-89 293.0 In-house 13-263 (297) alignment
Range on Protein: 202-450
Range on HMM: 13-263/297.0
EEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILkplpshEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVI
  ..|..  . . |   ..... ...|...||....| ||..|..|      ..  .||||||..|||.  ...||||||. ||. ||||..|... .||
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMVTNLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQV--LPDYTVRELQLILLGSDqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--P
||.|.|.| ||.||.||||.   .|..||.|.|||.. .|  |.|||.|.|..  .|.. .....|..|.|.||||||||...|.|.| ..... .|  |
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

TKGPMLVHCSAGVGRTGTFMAIDMGLQQAE---KEGGIDIISIINRMRQQRMFMVQTR
 .||.||||||||||.||| |.|. ||| |   ||||.|| .... .|.||...||| 
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl

0047943 (Phosphotyrosine protein) phosphatases II 197-450 1.5e-88 292.1 In-house 7-258 (273) alignment
Range on Protein: 197-450
Range on HMM: 7-258/273.0
HANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILkplpshEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQE
....   ..... |. .  . ....... ..|| .||....| ||..|..|      ..  .||||||..||| .  ..||||||. ||. ||||..|..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

KPHVIVMVTNLMEGGRNKCHQYWPDSD---SVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
. .||||.|.|.| ||.||.||||..    |..||.|.|||.. .. .|||||.|.|  ||... ....|..|.|.|||||||.. .|.|.| . ... .
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkal

KP--TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.    .||..||||||||||||| |.|. |.| |||||.|. ......|.||. |||| 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp

0043336 (Phosphotyrosine protein) phosphatases II 185-450 6.3e-87 286.8 In-house 3-263 (278) alignment
Range on Protein: 185-450
Range on HMM: 3-263/278.0
PVGKFGEFVADGHANNDEEFMKQYALFHNDLDkHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMAN
.| .. ..... ..|.   .....  ...     ...|. ...||..||....| || .|..|..|.....  .||||||..|||.   ..||||||. .
svkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgPlpe

TLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPdSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQ
|. ||||..|... ..|||.|.|.| ||.||.|||| ..|..||.|.|||.. ..|.||||| | .  ||.... ...|.||...||||||||  ...|.
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllld

FHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
| ..... ... .||.||||||||||||||.|... |.|.|||||.|. ......|.||. .||| 
flkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp

0045450 (Phosphotyrosine protein) phosphatases II 185-450 8.7e-85 280.4 In-house 10-290 (307) alignment
Range on Protein: 185-450
Range on HMM: 10-290/307.0
PVGKFGEFVADGHANNDEEFMKQYALFHNDLD--KHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHeGCQNDYINASFI--------DGYSSAYR
.. |.  .|.  .... . . |..  . .  .   .|..|. ...||..||....| ||..|..|..|...    .||||||..        ||| .  .
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrk

YIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSV-YYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDH
.||||||. .|. ||||..|... .||||.|.|.| ||.||.|||||.... .||.|.|||.....|..|||| | .  |. .......|..|.|.||||
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

GVPEYATSILQFHRRIKNEY--KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQRMFMVQTR
|||..  ..|.| ..... .   | .||.||||||||||||||.|... |.| ||||    .|. ......|.||. .||. 
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

0039614 (Phosphotyrosine protein) phosphatases II 197-450 1e-84 279.8 In-house 27-275 (297) alignment
Range on Protein: 197-450
Range on HMM: 27-275/297.0
HANNDEEFMKQYALFHNDLDKheMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHeGCQNDYINASFIDGYSS-AYRYIATQGPMANTLVDFWRLIWQ
.||.   .....    .  .   ..|. ...||..||....| ||..|..|||....    .||||||..|||.    ..||||||. .|. ||||..|.
kansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

EKPHVIVMVTNLMEGGRnKCHQYWPDSDSvYYGPFKVTLIDKQVLPDYTVRELQLILlgsDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-
.. .||||.|.|.| || ||.||||.. . .||.|.|||.. ..|..||||.| .     .......|....|.|||||||......|.| . ... .. 
qgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealae

-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
 | .||.|||||||||||||| |... |.| |||||.|. ......|.||. .||| 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtp

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 184-451 7e-84 276.6 In-house 2-267 (318) alignment
Range on Protein: 184-451
Range on HMM: 2-267/318.0
IPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMA
|.| .. . |.  ... . .. ..|  .. . ..   . |... ||  ||. |.| ||. |. |..| ..||   |||||..|||| .   |||.|.|..
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeeg..sDyinanyidGyrrkkayiaaqaPlp

NTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQpPLMITQYHFTSWPDHGVPEYATSIL
.|. ||||..|. .  ||||.|...| |..|.|.|||...|  ||  .|.| ..  | ||..||...   ....   .. |||.|||||.|||| ..|.|
etieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeee.srqvrqyhytsWpdegvpesgasll

QFHRRIKNEY-KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
.. |....   |...||..|||||||||||.|.|.|. |.....|. .|.  .....|.||  ||||. 
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqted

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 192-452 1.7e-83 275.0 In-house 11-267 (288) alignment
Range on Protein: 192-452
Range on HMM: 11-267/288.0
FVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWR
 ||  .|.| ..| ..|    .   ... |..   .|.. ||.||.| || .|. || |.  .  ..||||||.|||. .  .|||||||.|.|. |||.
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeea..gaDYinasyidgekkkkkyiatqgPladtvndfWe

LIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDS-VYYGPFKVTLIDKQVLPDYTVRELQLIllgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK
|....| . |||.|.|.|||..||..||||.|  . || ..|||.... | |...|.| |     ..  | ||||....|||||||| .. .|.. | .|
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvk

NEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
.  .   ||..|||||||||||||.|.|. ... |.|  ||........|.||...|||  .
vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkq

subfamily_PTPRG_pd Subfamily PTPRG 184-450 7.3e-83 273.7 In-house 1-273 (563) alignment
Range on Protein: 184-450
Range on HMM: 1-273/563.0
IPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKH--EMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCQnDYINASFIDGYSSAYRYIATQGP
.|| .| . ||. ||..|  | ...   ..   ..  ... |  ..||  ||  |.. ||  |. |.||| ...   |||||..||||  .  .||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

MANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLIL---L-GSD-QPPLMITQYHFTSWPDHGVP
...|. ||||.||... ..|||.||| | ||.||..|||  .|. || ..||||...||  ||||.|..       ... .  ....|||.|.|||||||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

EYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
|...  |.| .. .   | . ||..||||||||||||....|  |.| ..|  ...  .. ..| || |.|||.
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqte

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 184-451 1.8e-82 271.9 In-house 5-270 (319) alignment
Range on Protein: 184-451
Range on HMM: 5-270/319.0
IPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKhEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMA
|.| .. | .   ... .  . |.. |...  .. ... .  ..||. ||..|.| ||  |..|..|.  ||   |||||||||||    ..||||.|..
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgveg..sdyinasfidgyqerekfiatqaPle

NTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSIL
||. ||||..|.|. ...||.|.| | .. |...|||. . . || . ||| ... | || .|.|.|  . |.    .......|.||||.|||.|||.|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

QFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
.. .||..  . ...||. |||||||||||||...|. |.. ..|| .|. |...|.| || .|||. .
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpe

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 199-449 4.5e-82 270.1 In-house 12-278 (301) alignment
Range on Protein: 199-449
Range on HMM: 12-278/301.0
NNDEEFMKQYALFHNDLDKhEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKP
.. ..| .||   ..  || ..|...|..||.||||.|. ||||||||||| |. . ||..|||||.|||||.. ..||.|||| .||||||||||||||
khsnkfeeqykelkegedk.sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

HVIVMVTNLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQVLPDYTVRELQLILL--------------GSDQPPLMITQYHFTSWPDHGV-PEYATS
  ||||||| || ..||.||||.|  .| ..|||.|||...||.||...|.|....                ||. .  ..|.. |.||..|| .|..| 
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQT
.   .  |. . |. .||..||||..|.|.|.......|| |.  || .|.. .....|.... .|.|
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtT

DSPc_SM00195 206-450 4.7e-80 264.1 In-house 4-248 (263) alignment
Range on Protein: 206-450
Range on HMM: 4-248/263.0
KQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVT
...    .   ..|.| .  .|||  ||..|.|.||..|..||. ...   ..|||||..|.|...  .|||||||. .|. ||||..|.|| ..|||.|
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQVLP-DYTVRELQLILLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLV
. .| |..||..|||..  ..  .| ..|.|....  . ....|.|.|   |  . .  .|||....|||||||. ..|.|.. | .|.... ..||..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
||||||||||||..||. |.. |.|  .|| .|....|.||. ||||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

PTPc_SM00194 206-450 4.7e-80 264.1 In-house 4-248 (263) alignment
Range on Protein: 206-450
Range on HMM: 4-248/263.0
KQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVT
...    .   ..|.| .  .|||  ||..|.|.||..|..||. ...   ..|||||..|.|...  .|||||||. .|. ||||..|.|| ..|||.|
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQVLP-DYTVRELQLILLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLV
. .| |..||..|||..  ..  .| ..|.|....  . ....|.|.|   |  . .  .|||....|||||||. ..|.|.. | .|.... ..||..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
||||||||||||..||. |.. |.|  .|| .|....|.||. ||||.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtl

0040439 (Phosphotyrosine protein) phosphatases II 219-450 5.2e-80 263.9 In-house 2-232 (249) alignment
Range on Protein: 219-450
Range on HMM: 2-232/249.0
EMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSheGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQY
|....  ..||..||....| || .|..|..||.  .  .||||||.|||| .  |.||||||. .|. ||||..|... .||||.|.|.| ||.||.||
eysvallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMA
||...|..|| |.|||.. .|..|||||.|.|  |  |...........|.|||||||..  ..|.| ..... ..  |..||.|||||||||||||| |
wplggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

IDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
... |.| |||.|.|. .... .|.||. .||. 
aylmleqlekelgvdleeavkllrsqRpgavqnp

0045098 (Phosphotyrosine protein) phosphatases II 204-450 1.2e-79 262.9 In-house 9-258 (278) alignment
Range on Protein: 204-450
Range on HMM: 9-258/278.0
FMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIIlkplpshegcqnDYINASFIDGYssAYRYIATQGPMANTLVDFWRLIWQEKPHVIVM
.. ..  ..   .  |.| ..  .|...||....| || .|..            ||||||.||||    ..||||||. .|. ||||..|... .||||
lllefefllllgipseitpalylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

VTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILL---GSDQPPLMITQYHFTSWPDHGVPEYA--TSILQFHRRIKNEYK----
.|.|.|.||.||.||||...|..||.|.|||.. .||.|||.| | .. |    .| ... .|..|...|||||||..   .|.|.. ..|.. .|    
ltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

---------PTKGPMLVHCSAGVGRTGTFMAIDMGLQQAekEGGIDIISIINRMRQQRMF-MVQTR
         . .||.|||||||||||||. |... |..   |||.|. .... .|.||.. .||. 
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 195-451 6.5e-79 260.0 In-house 8-263 (281) alignment
Range on Protein: 195-451
Range on HMM: 8-263/281.0
DGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPlpSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIW
. ..|... |...|. ...   ..  | | ...|.  ||..|.  ||  |. ..|  ..|  ..|||||.|..||..  .|||||||. ..||.||...|
qlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtp..neenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvw

QEKPHVIVMVTNLMEGGRNKCHQYWPDSD-SVYYGPFKVTLIDKQVLPDYTVRELQLilLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIK-NE
..| ..|||||. .|.|. |||.|||| . .. || ..|. . ..  . |  |...|    .. ..  ..| ..|.|||||||. .. .|.|.. ..  .
eqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlklt

YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMFMVQTRA
 | || |...|||||||||||..|.|  ....|.|   .|.  ... .|..|..|||| .
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvv

Y_phosphatase Protein-tyrosine phosphatase 228-450 8.4e-79 259.7 Pfam-A 1-223 (235) alignment
Range on Protein: 228-450
Range on HMM: 1-223/235.0
NKPLNRFRNVLVYDDNRIILkplpSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWP--DSDSV
||  ||....|.||..|. |    .... ..|||||....||..  ..||||||. .|. ||||..|||| .||||.|.|.| ||.||.||||  ...|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

YYGPFKVTLI-DKQ-VLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
.|| .||.|  ...    .||.|.|.|   .... . ...|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AEKEGGIDIISIINRMRQQRMFMVQTR
.|.|. .|. .|....|.||. |||. 
leaeeevdvlqivkelRkqRpgmvqsl

Y_phosphatase Protein-tyrosine phosphatase 228-450 8.4e-79 259.7 In-house 1-223 (235) alignment
Range on Protein: 228-450
Range on HMM: 1-223/235.0
NKPLNRFRNVLVYDDNRIILkplpSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWP--DSDSV
||  ||....|.||..|. |    .... ..|||||....||..  ..||||||. .|. ||||..|||| .||||.|.|.| ||.||.||||  ...|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

YYGPFKVTLI-DKQ-VLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQ
.|| .||.|  ...    .||.|.|.|   .... . ...|.|.|.|||||||| ..|.|.. |..... ....||..|||||||||||||.|.|. |.|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

AEKEGGIDIISIINRMRQQRMFMVQTR
.|.|. .|. .|....|.||. |||. 
leaeeevdvlqivkelRkqRpgmvqsl

0042113 (Phosphotyrosine protein) phosphatases II 221-450 2.2e-78 258.3 In-house 2-229 (245) alignment
Range on Protein: 221-450
Range on HMM: 2-229/245.0
TISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWP
...  ..||..||....| ||..|..|.| .....  .||||||..|||    ..||||||...|. ||||..|... ..|||.|...| ||.||.||||
svallpenkdknrysdilpydhtrvklspdggdld..sdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

DSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK-PTKGPMLVHCSAGVGRTGTFMAIDM
...|..|| |.|||.. ..|.|||||.|..  |  | .......||...|||||||..  ..|.|...... .. . .||.||||||||||||||.|...
lgesltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

GLQQAEKEGGIDIISIINRMRQQRMFMVQTR
 |.|.|||.|... ... ..|.||. .||| 
mleqlekelgvsleeavkelrsqRpgavqtp

subfamily_PTPRA_pd Subfamily PTPRA 183-451 4.2e-76 250.9 In-house 13-282 (330) alignment
Range on Protein: 183-451
Range on HMM: 13-282/330.0
LIPVGKFGEFVADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPM
 .|| |. | .    |.. . | ...  .     .  . ..  ..||  ||. |.| || .|.|| ..  .|  . |||||||||||    ..||.||| 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaqGPk

ANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSD---QPPLMITQYHFTSWPDHGVPEYA
..|. ||||.||. | . |||.|.| |  ..||.|||||  .| ||  .|.. |..|| |||||.. .  |.     ... ...|.||||||| |||  .
eetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

TSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
  .|.. ...|.  . . ||. |||||||||||||...|  |.. . |. .|.  ...|.|.||  ||||  
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtde

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 206-452 7.4e-76 250.2 In-house 34-278 (298) alignment
Range on Protein: 206-452
Range on HMM: 34-278/298.0
KQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVT
..     ......|.... ...||  ||. ... .|  |..|.   . |  . |||||||...|.    .||||.|. .|..||||....|.  .|||.|
qrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedade..esdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmlt

NLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDqPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKG--PMLVH
|| | .. |.|.||||. .  || ..|.|  |..  |..||.|..    ..    .. | |||||||.||||.|||.|.. |...  ..   |  |..|.
nleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivq

CSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
|||||||.|||.|||  |....||  .|.  .....|..|. .|||...
CsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeq

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 465-730 1.6e-74 245.8 In-house 19-286 (305) alignment
Range on Protein: 465-730
Range on HMM: 19-286/305.0
TGQTGYNKQFTVLEQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQP--NYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAI
. ..|...|.  | .  ... .|... |...|....... |..|  ..  | ...  .|||| |||.||..|..|.| .|. .||..||..| .. |. |
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLCQEKENDEEVCYKYWPTEATE-VIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNT
|||.. .|.... |..|||.. || . |||.|..| .|. .  |.|| ..| .. .    . |.|||.| |  .| ..   ..| ......|.|... ..
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
...||||..|||. .|.|    ....|.|.|.|||.|||  | .... ||| .||  ...... .. ..
pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

0037934 (Phosphotyrosine protein) phosphatases II 220-450 9.3e-74 243.3 In-house 2-228 (243) alignment
Range on Protein: 220-450
Range on HMM: 2-228/243.0
MTISVSQKNKPLNRFRNVLVYDDNRIILkplpshEGcqNDYINASFIDGYSsayRYIATQGPMANTLVD----FWRLIWQEKPHVIVMVTNLMEGGRNKC
..|. .. |.. ||....| ||..|..|      ||  .|||||..|...    |.||||||. .|. |    |||..|... .||||.|.|.| ||.||
fsiallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekc

HQYWPdsDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--------YKPTKGPMLVHCSAG
.||||  ..|.||.|.|||.. ..|.|||||.|.|  |. |........||...|||||||.  ...|.|.. ...         . ...||.|||||||
aqywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTFMAIDMGLQQAekegGIDIISIINRMRQQRMF-MVQTR
||||||. |... |..     |.|. ......|.||.. .|||.
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtp

subfamily_PTPN6_pd Subfamily PTPN6 215-451 2.3e-73 241.9 In-house 41-284 (306) alignment
Range on Protein: 215-451
Range on HMM: 41-284/306.0
LDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpSHEGCQNDYINASFIDG--YSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGR
 .... . .  ..||  ||..|.| .|..|.|||   ...  ..|||||..|..   .|  .|||||| . .|. ||||..|||. .||||.|. .| |.
kkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgk

NKCHQYWPDSDS-VYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK----GPMLVHCSAG
.|| .||||. .   ||  .|| .... | ||..|||..    ...    . ||||.||||||||.    .|.| . ...... ..    ||..||||||
ekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaG

VGRTGTFMAIDMGLQQAEKEG---GIDIISIINRMRQQRMFMVQTRA
.||||||. ||. |.. ||.|    ||| .... .|.||  .||| .
iGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteq

subfamily_Ptp69D_pd Subfamily Ptp69D 193-449 3e-73 241.6 In-house 13-271 (307) alignment
Range on Protein: 193-449
Range on HMM: 13-271/307.0
VADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRL
.   . . |. ..| |   ..   ... ..|  . |.  ||. ..  .|..|..||... .|  . |||||||| ||    ..|| |.|. .|. ||||.
lksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdPveatigDfWRm

IWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQ----PPLMITQYHFTSWPDHGVPEYATSILQFHRR
|.. . ..|||..|| |  |.||..|||. | | ||   |.|....  .||. |||..   . .         ..|||.|.|.|  ||| |...|.. ..
iaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieq

IKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQT
... ||  ..|..|||||||||.|.|.|.|. ||| ..|  .||. ..  .|.|| ..|| 
vrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs

0050432 (Phosphotyrosine protein) phosphatases II 464-734 1.8e-72 239.6 In-house 38-306 (308) alignment
Range on Protein: 464-734
Range on HMM: 38-306/308.0
ETGQTGYNKQFTVLEQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLkGQQPNYINAVYVDSY--KERKAFIIAESPMFSTVRNFWKMIEDINVTA
 .. ......|  | .|.  . | ..    .||||||.. .|| |. ||.| ..  .|||| ||| |  | ...||.. .|. .|| .||.|. . ||. 
aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVMLCQEKENDEEVCYKYWPTE--ATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrrsG
||||... ||. | |..|||.|   . ...| ....||.|| .| || ||.|..|. .| | ..| ... |.|.  |  .  ...| .||...|..   .
IvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrksl...p

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
.  ||||||. |||.. |.|. . ..  ..|| .|||...|  | |.||.|||.|||. ...... || ... . 
ggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 225-452 2.5e-72 238.1 In-house 6-230 (250) alignment
Range on Protein: 225-452
Range on HMM: 6-230/250.0
SQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCqnDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNkCHQYWPDSDS
  .||  ||. ... .|  |..|..  . . .  |||||||..||.    .||||||. .|..||||....||  .|||.||| | ... .|||||   .
kpqnkeknryadiialdssrvvLekekgdkes..dyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

VYYGPFKVTLIDKQVLPDYTVRELQLILlGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQ
  ||  .|.| .|..  |||.|.|.|    . .   .. |.||..||| ||||.||..|.. .... . .   ..|..|.|||||||.|.|.|||  |..
ekyGdvtvsllskeefadytkrklklsk.akkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

AEKEGGIDIISIINRMRQQRMFMVQTRAR
..||  .|.  .|...|..|. .|.....
lkkekvvdvfkvikvlrkdrphavesleq

subfamily_PTPRK_pd Subfamily PTPRK 222-450 9.3e-72 236.5 In-house 37-263 (314) alignment
Range on Protein: 222-450
Range on HMM: 37-263/314.0
ISVSQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPD
 .  ..|.  ||. ..| ||  |..|...  ..  ..|||||..||.|  .  .|.||||. .|. |||||...|.   |||.|.|.| || || .|||.
aakkdenreknrsgdilaydrsrvfliti..dgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

SDSVyYGPFKVTLIDKQVLPDYTVRELQLILL-GSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMG
  .| ||..||.|.. ..| .. || ...  |  . .   .. |..|..||||.|| .||..|.. ||.|.  ....|...|||||| ||||||.|||. 
dtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv

LQQAEKEGGIDIISIINRMRQQRMFMVQTR
|. .|.|| .|.  ..  .|.... ||.| 
ldmieregvvdvfnavktlrsrkvnmvete

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 184-451 9.6e-72 236.6 In-house 6-266 (315) alignment
Range on Protein: 184-451
Range on HMM: 6-266/315.0
IPVGKFGEFVADGHANNDEEFMKQYALFHNDlDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILkPLPSHEgCQNDYINASFIDGYSSAYRYIATQGPMA
||. ..  .||. .|.  . | ..|       . | . ..   .||  ||. |.. ||  |. | ||   .  . ||.||.|||||.   ||||.||| .
ipldqlityvaqkkastkngfkqdyesipgg.qlhpldvakkienkqknryiniiaydksrvql.pllend.phsdyvnanfidGynkkrryiaaqgpnv

NTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSdSVYYGPFKVTLIDKQVLPDYTVRELQLIlLGSDqpPLMITQYHFTSWPDHGVPEYATSIL
... |||||...|.   |||.|||.|| ..|. .||||   | ||.. ||.....|  .|||| |  .  |..     . |.|.||||| |||.|.....
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvv.fgdn..irevvqlhytswpdmgvpkytiplm

QFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
...|..|   . . |...|||||||||||||...|  |.||| |  ||.  .|...||.|. |||. .
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvae

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 453-731 4.6e-71 234.5 In-house 12-294 (298) alignment
Range on Protein: 453-731
Range on HMM: 12-294/298.0
SMIGKLSEQDPETGQTGYNKQFTVLEQVTQKPDEVTHNIA--SQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFST
 .. ||.. ..... |||...|  |..|... .| ....|  ..||.||| .. .. |  ||||.     .. .||||.....||.|.|||... |. .|
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltet

VRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILM
| .||.|. . ....|||| . .| |.  . ||||.| .|  .|| ...||..| .  .. |......| .  ....|.| . | |  .|. . ....| 
vedFWrmvteedigtiVmltnleeldktkyhkywPdegke.tygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvld

ILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFM
.|......|...||....|.||. ||||  |.|  . ... |.| |.|||||.|  |...||.||| |||. |.|.|. .|||| 
llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn

0046845 (Phosphotyrosine protein) phosphatases II 472-735 2.8e-70 232.2 In-house 4-282 (284) alignment
Range on Protein: 472-735
Range on HMM: 4-282/284.0
KQFTVLEQVTQKPD-EVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ-----PNYINAVYVDSY-----KERKAFIIAESPMFSTVRNFWKMIEDINVT
..|  | ..| |.  .... .. .|..|||....|| |. ||.||  .      .|||| ||| |     . .|.||..  |. .|| .||.|. . ||.
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

AIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRR-SG
 ||||... ||. | |..|||.| . ...|.....||.|| .| || ||.|..|.  .|  ..| ....|.|  .|  .  . .| .|..... ... .|
vIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

NTSIVVHCSDTVGRSAMFCAAATTINKCKTEG---VIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYSN
.  ||||||. |||...|.|. . ..  ..||   ..||....|  | |.||.|||.|||. ..|... || ... . .
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle

0036941 (Phosphotyrosine protein) phosphatases II 467-732 9.2e-70 230.6 In-house 12-282 (297) alignment
Range on Protein: 467-732
Range on HMM: 12-282/297.0
QTGYNKQFTVLEQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLC
 ... |.|  | .. ... . .. .  .|..|||.. .|| |. ||.|...  .|||| ||| |.  ..||... |. .|| .||.|. . ||| ||||.
lalllkefeellpl.lllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

QEKENDEEVCYKYWPTE-ATEVIFGEYSIKLLNEEL--YDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS-GNTS
.. |.. | |..|||.|   .. .|.....||..|   .| || ||.|.... ..|  ..| ....|||  .|  .... .| ..|...| .. . ... 
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

IVVHCSDTVGRSAMFCAAATTINKCK---TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFML
..||||. ||||..|.|| . ..  .   .|| .|.....|. | |.||.|||.|||. . |... .| ....
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

0051299 (Phosphotyrosine protein) phosphatases II 465-727 9.3e-70 230.7 In-house 20-286 (288) alignment
Range on Protein: 465-727
Range on HMM: 20-286/288.0
TGQTGYNKQFTVLEQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVT
.|.||. ..|  | ... .  .... .  .|..|||.. .|| |. ||.|.        .|||| |.| |.  ..||... |. .|| .||.|. . ||.
ngltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

AIVMLCQEKENDEEVCYKYWPTeATEVIFGEYSIKLLNEELYDLYTERTIEIKNKM---KGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRr
 ||||... |.. | |..|||.  . ...|.....||.|| .| || ||.|..|.    ..|  ..| ... |.|  .|  .  ...| .|....| .. 
vIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.

SGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
||.  .|||||. |||...|.|. . ..  ..||..||....|  | |.||.|||.|||. ..|..  ||
sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0047943 (Phosphotyrosine protein) phosphatases II 462-727 1.6e-69 229.7 In-house 6-272 (273) alignment
Range on Protein: 462-727
Range on HMM: 6-272/273.0
DPETGQTGYNKQFTVLEQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTA
.. .| |.. ..|  | ...  . . .. .  .||||||.. .|| |. ||.|...  .|||| ||| |.  ..||... |. .|| .||.|. . ||. 
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMLCQEKENDEEVCYKYWPTEAT--EVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGsRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS-
||||... |.. | |..|||.|    ....|.....||.|| .| || ||.|..|.  |   ..| ... |||  .|  .  . .| ..|...|... . 
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealp

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
.|. .|||||. |||...|.|. . ..  ..|| .||....|  | |.||.|||.|||. . |..  ||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_PTPN12_pd Subfamily PTPN12 218-451 2e-69 228.7 In-house 30-264 (290) alignment
Range on Protein: 218-451
Range on HMM: 30-264/290.0
HEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQ
.. . . ...|.  ||....| || .|. |.   ..|  ..|||||.|| | ..  .|||.|||...|| ||||.||. . ...||. ...| |..||..
ysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPDS--DSVYYGPFKVTLIDKQVLP-DYTVRELQLILLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTF
|||..  ... .|.|.|||.... .  |...| |..   .  .   ...|.|.|.|||||||. |.|.|.. . ...  .  . |..|||||||||||| 
YWpeegeeelefgefevtleeekavdddflirtLkveaqkesr...kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGti

MAIDMGL---QQAEKEGGIDIISIINRMRQQRMFMVQTRA
.|||.     ..   .  .|. ... ..|.||  .|||. 
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtke

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 184-450 1.9e-68 225.7 In-house 3-263 (315) alignment
Range on Protein: 184-450
Range on HMM: 3-263/315.0
IPVGKFGEFVADghaNNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSSAYRYIATQGPMA
||| .|  ||     |    .. .      | | .. ...  . | . ||..|.| .| .|..|. .   .  ..||||||.| .. .   |||.|||  
ipvaqfpafvnk...nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvklevi..ddsPdsdyinasyiksvdddkayiasqgPlk

NTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPD--SDSVYYGPFKVTLIDKQVLPDYTVRELqlILLGSDQpPLMITQYHFTSWPDHGVPEYATS
 .. ||||...|||.  |||||.. || . || |||||  .||| .| .||.|.. .   | ..|.|  ..  |..    .||..|| |||.||.. ..|
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrksee.srtvtqfqftewPdkGvdkqtss

ILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.|.. . .| . .. . ..|||||||||||| ...||  ..|....  .|.  ... .|..|...|||.
llklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqte

subfamily_PTPN9_pd Subfamily PTPN9 193-450 2.4e-68 225.3 In-house 7-276 (297) alignment
Range on Protein: 193-450
Range on HMM: 7-276/297.0
VADGHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRL
||  .... .  .|.||  .|   . ... | .. |   ||. .|| ||. |. |. .. .|  . |||||.|.|||     .||||||. .|  ||||.
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfWrm

IWQEKPHVIVMVTNLMEGGRNKCHQYWP--DSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIK
.|...  ||||.| ..| || || ||||  . .|  .| ..|. .. ..  ||.|| |..     ..    .| . |.||||.|||. |.|.|.. . ..
vWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktees.rkvthfqflsWPdyGvPssaaslldvlekvr

N-------------EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.             ...|.. |..||||||.||||||...|. |.. |..| .|..  ....|.|| |..|| 
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtp

subfamily_PTPN3_pd Subfamily PTPN3 204-451 1.7e-67 222.3 In-house 17-262 (280) alignment
Range on Protein: 204-451
Range on HMM: 17-262/280.0
FMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFID----GYSSAYRYIATQGPMANTLVDFWRLIWQEKPH
 ..|.  ..    . .....   .| . ||.|..| ||. |..||        ..|||||....    . .   ||||||||.|.|  |||...|..| .
vlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss

VIVMVTNLMEGGRNKCHQYWPDS-DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSdQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKG
.|||.|.|.| || |||||||.. |.. || |.|..  ..    | .||| |    . .   .|.|  ...|||||||. ....|.| .|...  . .. 
livmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdket.keerkilqlqylaWpdhgvPddsadflefvervrklrsgkee

PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
|..||||||.|||| ...... |.  |..  . .. |. .||.||. .||| .
PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtas

0040438 (Phosphotyrosine protein) phosphatases II 480-730 3.2e-67 222.4 In-house 28-279 (317) alignment
Range on Protein: 480-730
Range on HMM: 28-279/317.0
VTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEV
 ..|.|. .. .  .||||||.. .|| |. ||.|.  .     .|||| ||| ......||.. .|. .|| .||.|. . .|| ||||....|.. | 
lslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrek

CYKYWPTeATEVIFGEYSIKLLNEELYDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrSGNTSIVVHCSDTVGRSA
|..|||.  ... .|.....||.|| .. .| ||.|.... ...  ..| ... |||   |    .. .| .||.... .. .... ..||||. |||..
caqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
.|.|| . .. ...|| .||....|  | |.||.||| |||. . .... ||  .
tfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 215-450 5.7e-67 221.3 In-house 48-277 (319) alignment
Range on Protein: 215-450
Range on HMM: 48-277/319.0
LDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTnlmeggRNK
 .  ..| .  ..||  ||. |.| .| |.. |..|   |.   |||||||..|| .  .|||.|||. ||| ||||.||. .   ||..|      ..|
vnladqtfanldqnkdknriinilafdknvvklerliGeef..sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdk

CHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTG
| ||||    . .. ||| .   .   .|.||...|   |  .    |||.||  |||.|||.|.. .... ....     .  . ...|||||||||||
csqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtG

TFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.....|. |.. ..|  .|.  ... .||||  .||  
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

0045450 (Phosphotyrosine protein) phosphatases II 458-727 8.3e-67 221.4 In-house 17-304 (307) alignment
Range on Protein: 458-727
Range on HMM: 17-304/307.0
LSEQDPETGQTGYNKQFTVLEQVTQK-PDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG-----QQPNYINAVYV--------DSYKERKAFIIAESPM
|  ... .. ||. |.|  | .|| . ..| ..    .||||||.. .|| |..||.|.      .  .|||| ||        |.|.  ..||.. .|.
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl

FSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQA
 .|| .||.|. . .||.||||....|.. | |..|||.| .|. .|.. ..||.|| .| || ||.|.... . |  ..| ... |||   |  .  . 
petvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfee

ILMILEEMNKTQRRS-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
.| ..||..| .... ... ..||||. |||...|.|| . .   ..||.   .|.....|  | |.||.||. |||. . |... .|
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 220-450 2.4e-66 218.9 In-house 35-262 (515) alignment
Range on Protein: 220-450
Range on HMM: 35-262/515.0
MTISVSQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYW
 |..  . | . ||..|.| || .|..|. .  ..  ..||.|||.| .. .   |||.|||   .. |||||..||..  |.|||.| || . || .||
qtvaqeeinfkknryknilPydsvrvklevi..ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyW

PD--SDSVYYGPFKVTLIDKQVLPDYTVRELQLIlLGSDqpPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAI
||  .||| .| .|| |.  .   . . |.|...  |.|     .||.||| |||.|||. ..|.|.. . .| .    . |...|||||||||| ...|
PdkpgdsvkfGsikvelvsleactggikrkltvl.kgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisi

DMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
|  . .|..   .|.  ... .||.|...|||.
dsvvahakttrmvdvfnfvtnirqkrpylvqtq

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 216-451 4.3e-66 218.3 In-house 13-242 (284) alignment
Range on Protein: 216-451
Range on HMM: 13-242/284.0
DKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTnlmeggRNKC
.  ..| .  ..||  ||. ..| .| |.. |..|   |.   |||||||| || .  .|||||||. ||| ||||.||. .   ||..|      ..||
ngtdqtfanldqnkdknrighilafdknvvklerliGeef..sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkc

HQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPTKGPMLVHCSAGVGRTGT
 ||||    . .. ||| .   .   .|.||...|   |  .    |.|.||  |||.|||.|.. .... ....     .  . ...|||||||||||.
sqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgv

FMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
....|. |.. ..|  .|.  ... .||||  .||  .
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlv

0039614 (Phosphotyrosine protein) phosphatases II 464-729 5.7e-66 218.3 In-house 28-291 (297) alignment
Range on Protein: 464-729
Range on HMM: 28-291/297.0
ETGQTGYNKQFTVLEQVTQkpDeVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ-----PNYINAVYVDSYKE-RKAFIIAESPMFSTVRNFWKMIEDI
 .. |.. ..|  | ...   |  ..    .||||||.. .|| |..||.||.        .|||| ||| |.   ..||..  |. .|| .||.|. . 
ansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweq

NVTAIVMLCQEKENDEeVCYKYWPTEATevIFGEYSIKLLNEELYDLYTERTIEIKNkmkGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRR
.||.||||....|..   |..|||.| .   .|.....||..| .| || ||.|..|   .|  ..| ..| |||  .|   ... .| .||.... ...
gvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealae

S-GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDS
. ... ..||||. |||...|.|| . .. ...|| .||....|  | |.||.||| .||. ...... .|  
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 207-450 1.7e-65 215.9 In-house 10-254 (274) alignment
Range on Protein: 207-450
Range on HMM: 10-254/274.0
QYALFHNDLDKHEMTISVSQKNkplNRFRNVLVYDDNRIILKPLPSHEgCQNDYINASFIDGYSSAY-RYIATQGPMANTLVDFWRLIWQEKPHVIVMVT
..     . |..|.... ||.    ||....|  .  |..|..  |..  . .|||| .| ||.     |.|||||..||. ||||.|.||. .||||.|
eflelPlnfdqeeldvfgsqtk...nryktilPnensrvllesessed.edssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmlt

NLMEGGRNKCHQYWPDSDSV----YYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPplmITQYHFTSWPDHGVPEYATSILQFHRRIKNE---YKPTKG
.| |  ..||..|.||. ..     || ....  ..    ||.||.| |  | . .    .. | .|.|||| .|. |...|.. . ....    .   .
klkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenakla

PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
|..||||||.|||| |.||.....| ..|. .|...|.  .|..|  ||||.
pvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 227-452 2.6e-65 214.9 In-house 7-229 (239) alignment
Range on Protein: 227-452
Range on HMM: 7-229/239.0
KNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYS-SAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSV
 ||  ||. |.. || .|..|. |      ..||||||..  |  |   |||||| .. .  ||||..|||.  ||||.| |.|| ..||||||||| | 
vnkaknryanivtydhsrvvleklsnd..phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

YyGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE
|   ..|||   .|. || .| . .  .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.
y.cnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

KEGGIDIISIINRMRQQRMFMVQTRAR
|.  .||.  .. .|..| .||||  .
kqktvdifnyvkairedrphmvqtseq

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 227-452 2.7e-65 214.9 In-house 6-228 (239) alignment
Range on Protein: 227-452
Range on HMM: 6-228/239.0
KNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYS-SAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSV
 ||  ||. |.. || .|..|. |      ..||||||..  |  |   |||||| .. .  ||||..|||.  ||||.| |.|| ..||||||||| | 
vnkaknryanivtydhsrvvleklsnd..phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

YyGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAE
|   ..|||   .|. || .| . .  .|  .    . ||||| |||.|||.|||..| ..|.| ..  |   | ..||||||||||.|. ||  |.||.
y.cnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

KEGGIDIISIINRMRQQRMFMVQTRAR
|.  .||.  .. .|..| .||||  .
kqktvdifnyvkairedrphmvqtseq

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 227-452 7e-65 213.6 In-house 2-227 (237) alignment
Range on Protein: 227-452
Range on HMM: 2-227/237.0
KNKPLNRFRNVLVYDDNRIILKPlpshEGCQNDYINASFIDGYSSA-YRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDS-
.||  ||. |. .|| .|..||      |.. |||||....|.  .  .|||.|||. ..  |||...||||  ||||.| |.|| . |||.|||..|  
enkiknrygnivaydhsrvvlkg....agsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

VYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTFMAIDMGLQ
  || . |.|  |. . ||||| | |   .. .   .| ||.||||||.|||......|.| ..| |. .  .  || ..|||||||||| |. ||  |.
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QAEKEGGIDIISIINRMRQQRMFMVQTRAR
||...  .||   .  . ..| ...||. .
qakekkvvdiynyvysieedrpyiiqtkdq

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 212-454 2.1e-64 212.1 In-house 17-256 (283) alignment
Range on Protein: 212-454
Range on HMM: 17-256/283.0
HNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPShegcqnDYINASFID---GYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLM
.  . . . .|.....||. ||.......| .|. ||...       |||||.||     |    .||..|.|. .| ||||.....||   |||.|.|.
rlsvpdldadiasadenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklq

EGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGV
|. | || ||||   |. ||.| ||| .      ....|| |   .| .  |... | .  | . |      |...| . | .  .  |||..||||.|.
edlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgi

GRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRARSM
|||..|.|.   ...|  |  .|. .... ||.||| .|||. . .
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyk

subfamily_PTPRD_pd Subfamily PTPRD 469-730 2.2e-64 213.1 In-house 24-284 (564) alignment
Range on Protein: 469-730
Range on HMM: 24-284/564.0
GYNKQFTVLEQVtqKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVM
  ....  .|.   .  ....  ...|| |||  . .. |. ||||.     .. .|||| ..|.|..|||.| .  |. .|...||.|. . |.. |||
kfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVm

LCQEKENDEEVCYKYWPTEAtEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIV
| . .|.... | ||||..  .  .||. ..| .|| .  |. ||...|.| .  | ..| |.. | |  .|  .  ...| ......... ....  ||
ltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkksses.reVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
||||  |||. .|..    ... |.|...|..|..|  | |..  ||| |||  |.|... .|...
VhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg

DSPc_SM00195 471-726 1.1e-63 210.4 In-house 3-261 (263) alignment
Range on Protein: 471-726
Range on HMM: 3-261/263.0
NKQFTVLEQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLC
...|. ||. |..  |.|... ..||.|||....|| |. || || ..     .|||| |.. ....|..|..  |. |||. ||.|. . .|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QEKENDEEVCYKYWPTEA-TEVIFGEYSIKLLNEELYD-LYTERTIEIKNKMKgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSgNTSIV
.|.||..| |..||| |. ..  ||..|.|| ..| ..  .. ||.|.... |    .|| |||...|. .|    .. .| .|....|....| .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
||||. |||...|... . ..|...|  .|.|...|. | |.||.||| |||. | |..  |
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 471-726 1.1e-63 210.4 In-house 3-261 (263) alignment
Range on Protein: 471-726
Range on HMM: 3-261/263.0
NKQFTVLEQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLC
...|. ||. |..  |.|... ..||.|||....|| |. || || ..     .|||| |.. ....|..|..  |. |||. ||.|. . .|. ||||.
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QEKENDEEVCYKYWPTEA-TEVIFGEYSIKLLNEELYD-LYTERTIEIKNKMKgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSgNTSIV
.|.||..| |..||| |. ..  ||..|.|| ..| ..  .. ||.|.... |    .|| |||...|. .|    .. .| .|....|....| .. ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
||||. |||...|... . ..|...|  .|.|...|. | |.||.||| |||. | |..  |
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

0043336 (Phosphotyrosine protein) phosphatases II 470-726 1.6e-63 210.1 In-house 22-276 (278) alignment
Range on Protein: 470-726
Range on HMM: 22-276/278.0
YNKQFTVLEQVTQkpDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVML
. ..|  | ...   |. .. .  .||||||.. .|| |..||.|.  .     .|||| ||| |.  ..||..  |. .|| .||.|. . .|| ||||
lllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmL

CQEKENDEEVCYKYWPteATEVIFGEYSIKLLNEELYDLYTERTIEIKNkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrSGNTSIVV
....|.. . |..|||   . . .|.....||.|| .| || ||.|..| .. |  ..|..|. .||  .|  .  . .| .|..... .. . |. ..|
telvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlV

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
|||. |||...|.|. . ..  ..|| .|.....|  | |.||.||| .||. ..|... |
HCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 467-734 1.8e-63 209.0 In-house 14-300 (301) alignment
Range on Protein: 467-734
Range on HMM: 14-300/301.0
QTGYNKQFTVLEQVTQKPDEVTHNiaSQNKDKNRSTQFLPPDNHRVVLKGQ------QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVT
......|.. |.....|. .|...  ..||  ||  .  . |..|..|| .      | .|||| |.|.|.|.|.||.|..|| .|...||..| .  ..
snkfeeqykelkegedksctvgls..eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

AIVMLCQEKENDEEVCYKYWPT-EATEVIFGEYSIKLLNEELYDLYTERTIE-----------------IKNKMkggSRHKVVQYQITGWEPNGEVTCHQ
.|||....||. .. |..|||. ||..  ||. ...| ||  |  .. | .                  .|...   | ..|.|.|.| |  .| |  ..
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvrepr

AILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
 .|...... ..|.. |   .||||||||.|| ..|.   ..  || |||.||||| |. | .||| |.| |||  |..... ||     |.
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstya

0045098 (Phosphotyrosine protein) phosphatases II 480-727 2.4e-62 206.1 In-house 18-272 (278) alignment
Range on Protein: 480-727
Range on HMM: 18-272/278.0
VTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVlkgqqpNYINAVYVDSYkeRKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKY
..  |.|.|...   |.|||| ...|| |. ||.      .|||| |.|.|  .|.||..  |. ||| .||.|. . ..|.||||....|.. | |..|
llgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPTeATEVIFGEYSIKLLNEELYDLYTERTIEIKNK---MKGGSRHKVVQYQITGWEPNGEVTCH--QAILMILEEMNKTQR------------RSGNTS
||     ...|.....||.|| .| || ||... |     ...  ..| ......|. .|  . .  . .| .||.... ..             .... 
wpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

IVVHCSDTVGRSAMFCAAATTINKCktEGVIDVFQVLKSQRIQKPG-SVQTVEQYKGIFEIVQIYL
..||||  |||.....|| . .  .  ||..|.....|  | |.|| .||. |||. ..| .. .|
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 467-723 4.2e-62 204.6 In-house 5-262 (283) alignment
Range on Protein: 467-723
Range on HMM: 5-262/283.0
QTGYNKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVD---SYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIV
..... .. ||....  . ... . |..|| |||  . .| |..|| || . ..|||||..    |||. | .||| ||.  ||..||||. | ..||||
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLCQEKENDEEVCYKYWPTEATEViFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWepngEVTCHQAILMI---LEEMNKTQRRSGN
|| . .|. .. | .||| . .|  .||. . | .|   . .. . . ....    |   .  ||. .|         |||.     .. .   |..| .
mltklqedlrikCsqyWPkrGsed.yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskk

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
. |||||| ..||.|.|.||...... .|| |.|||.|.|  | |... ||| .||| . |.|
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 493-734 1.3e-61 203.0 In-house 7-249 (250) alignment
Range on Protein: 493-734
Range on HMM: 7-249/250.0
SQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEvCYKYWPTEATEvI
 |||.||| ..... |. ||||. ..     .||||.....|.||||||.. .|. .|. .||.|. . ....|||| . ||.... . .|||.| .| .
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae.k

FGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHkVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCK
.|.  ..||..| .  || |.. . .. | ..|. |.|.. . |   |     .|.| .|......|...||. ..|.||  ||||  |.|  . ... |
yGdvtvsllskeefadytkrklklskakkaderi.vrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYS
.| |.|||.|.|  |...|..|.. |||  ..||.. .|||.  |.
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya

subfamily_PTPN23_pd Subfamily PTPN23 198-451 1.9e-61 202.4 In-house 11-267 (288) alignment
Range on Protein: 198-451
Range on HMM: 11-267/288.0
ANNDEEFMKQYALFHNDLDKHE--MTISVSQKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFIDGYSSA-YRYIATQGPMANTLVDFWRLIW
 ..  .. |........ ||.   ..|......   ||.|..| || ||. |.      | ..|||||||. . |.    .||||.|...|| |||....
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvy

QEKPHVIVMVTNLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
..|  ||||...  | |..|...||| .  ..| .|...||| ... .. .  |.|.|  |..|.   ...  ..||||..|||.   ..|||   ... 
eqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadav.ksvshlqltsWpelGvPasPetllqfldevesa

----YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGI-DIISIINRMRQQRMFMVQTRA
     ...| |..|||||||||||.|  .   ... ||. |. ||| ...|.|.|| ||||...
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqeke

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 184-450 2.6e-61 202.4 In-house 10-270 (297) alignment
Range on Protein: 184-450
Range on HMM: 10-270/297.0
IPVGKFGEFVADghaNNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYSSayRYIATQGPMA
||. .|  .|     | . .....  |       .. | .  . | . .|..|.| || .|..|. . ..   . ||.||||. |.    |.|.|| || 
iplsdfatlvqk...nrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivndd..pdsDyvnasfvkgnkh..rlittqmPmk

NTLVDFWRLIWQEKPHVIVMVTNLMEGGRnKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLIlLGSDQPPLMITQYHFTSWPDHGVPE--YATS
.|. |||.....|.. .|||.... |. . || .||.|. .. .|   |.|   .    .  |||..   |. .   .. ||.|..|||. |..   |.|
atvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevt.kgkakarrvvkqyqfveWPdkaverkdsass

ILQFHRRIKNEYKPTKG-PMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.|..   ...... ..  |.||||.||||||| ...||  . .|..|  .||  .....||.|...|||.
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtk

Y_phosphatase Protein-tyrosine phosphatase 495-723 6.3e-61 201.1 Pfam-A 1-233 (235) alignment
Range on Protein: 495-723
Range on HMM: 1-233/235.0
NKDKNRSTQFLPPDNHRVVLKGQQP--NYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWP-TEATEVIFGE
||.|||....|| |. || |||..   .|||| ||..||| |.||... |. ||.  ||.|. . .|..||||....|...| | .||| .| ... .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSIKLL-NEE-LYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
....|  .|.   . || |..|.|.| .   ...| |...|.|. .|  .. ...| ......|.. .. ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
|. .||.|..|. | |.||.||..|||. . ...
eeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 495-723 6.3e-61 201.1 In-house 1-233 (235) alignment
Range on Protein: 495-723
Range on HMM: 1-233/235.0
NKDKNRSTQFLPPDNHRVVLKGQQP--NYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWP-TEATEVIFGE
||.|||....|| |. || |||..   .|||| ||..||| |.||... |. ||.  ||.|. . .|..||||....|...| | .||| .| ... .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSIKLL-NEE-LYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
....|  .|.   . || |..|.|.| .   ...| |...|.|. .|  .. ...| ......|.. .. ....|||||. |||...|.|. . ......
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

EGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
|. .||.|..|. | |.||.||..|||. . ...
eeevdvlqivkelRkqRpgmvqsleqYiflykai

subfamily_PTPN13_pd Subfamily PTPN13 220-451 1e-60 200.3 In-house 29-256 (273) alignment
Range on Protein: 220-451
Range on HMM: 29-256/273.0
MTISVSQKNKPLNRFRNVLVYDDNRIILKplpsHEGCqndYINASFIDGY--SSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQ
 ... ...||  ||.|||| ||. |..|.     ||    |||||.|        |.|||.|||. .|  |||...|. | .||.|||.  |.|. |||.
cevgkkkenkdknryrnvlPydetrvklg....degg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchr

YWPDSDS---VYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTF
|||.| .   . .. ..|.|.. | | ...||.|... . | .    ... .|..|||||||  |...||| .....  .  .||..||||||.||.||.
ywPesknkklkvsnrlevellkvqkldgfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtl

MAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
..||. |.  |..  .|.  |....|.||  .|||. 
itidvvlglierdkefdvkeivrklreqrqgvvqtkd

subfamily_PTPN1_pd Subfamily PTPN1 204-450 2e-60 199.0 In-house 8-257 (290) alignment
Range on Protein: 204-450
Range on HMM: 8-257/290.0
FMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVM
. . |   ... ...... .  ..|..|||.|.|  ||  ||.|.        .|||||||...      .|| ||||..||   ||...|..| . .||
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle......radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

VTNLMEGGRNKCHQYWPDSD---SVYYG--PFKVTLIDKQVLPDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE--YKPT
. ...| ...||.||||  .   .. .    .||.|| ...   |||| |.|  | ...    |...|.|.||| ||||  .. |.|  ....    .. 
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqet.reilhfhyttwpdfgvpespaaflkflfkvresGslssd

KGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGG---IDIISIINRMRQQRMFMVQTR
.|| ..|||||.||.|||. .|  | . ||..    .||   .  .|..|. ..|| 
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta

0042113 (Phosphotyrosine protein) phosphatases II 492-727 4.6e-60 198.4 In-house 6-243 (245) alignment
Range on Protein: 492-727
Range on HMM: 6-243/245.0
ASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTeATEV
   ||||||....|| |. ||.|.  .     .|||| ||| |.  . ||..  |. .|| .||.|. . ..|.||||..| |.. . |..|||.  ...
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

IFGEYSIKLLNEELYDLYTERTIEIKNkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKC
 .|.....||.|| .| || ||.|..| .. .  ..|..|. ..|. .|. . .. .| .||...| .....|. ..||||. |||...|.|| . ..  
tygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

KTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
..|. .......|  | |.||.||| .||. . |... .|
ekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 218-451 2.1e-59 195.7 In-house 10-251 (270) alignment
Range on Protein: 218-451
Range on HMM: 10-251/270.0
HEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSheGCQNDYINASFIDGYSSA-YRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCH
.| ..    ..| |||....|     |..|..| .    .  |||| .. |....  .|||..||...|| .|||.||.|| . |||.|.|.| ||.|| 
sesdlpeaargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCe

QYWPDSDSV----YYGPFKVTLIDKQVLPDYTVRELQLILLGSDQpPLMitQYHFTSWPDHGVPEYAT------SILQFHRRIKNEYKPT-KG-PMLVHC
.||| .        .|  ||. . ..    | ...|.|   |. .  |.   .....|||||||. .       ..|.  | ...  | . |. |.||||
rYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeer.rlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

SAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
|||||||||..|.|....  |... .|...||...|..|| .||.  
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpe

subfamily_PTPRN_pd Subfamily PTPRN 196-452 2.8e-59 195.2 In-house 23-280 (297) alignment
Range on Protein: 196-452
Range on HMM: 23-280/297.0
GHANNDEEFMKQY-ALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFI-DGYSSAYRYIATQGPMANTLVDFWRLI
 | .| . . |.. || . . ...  ... ..||   || ..|| ||..|. ||   |.|  ..||||||.| |    |  |||||||.|.|. |||...
dhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasae..ksdyinasaildhdprapayiatqgplastvadfwqmv

WQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVL-PDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNE
|..   |||..|.| | | ..|..||||  |  |. ..| |. . .   || || . |  | ...    .||.|| |||..|||  | |.|.| |..   
weqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPasaksllefrrkvnks

YKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMFMVQTRAR
|.    |..||||.|.||||....||. |..  |    |||.. .. .|.||  .|.|...
yrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdq

0040439 (Phosphotyrosine protein) phosphatases II 487-727 1.8e-58 193.4 In-house 3-246 (249) alignment
Range on Protein: 487-727
Range on HMM: 3-246/249.0
VTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT
... .   ||||||.. .||.|..||.|.        .|||| |.| |.  ..||..  |. .|| .||.|. . ..|.||||....|.. | |..|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

eATEVIFGEYSIKLLNEELYDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS-GNTSIVVHCSDTVGRSAMFCAAA
  ... .|.....||..| .| || ||.|..|. . |. ..| ..|.|.|   |     . .| ..|...| ...   .. ..||||. |||...|.|| 
.ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
. ..  ..|. .|.....|  | |.||.||. |||. . |... .|
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 186-451 2e-58 193.0 In-house 7-275 (325) alignment
Range on Protein: 186-451
Range on HMM: 7-275/325.0
VGKFGEFVADGHANNDEEFMKQYALFHNDlDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSSAYRYIATQGPMANT
| .. |.|   .|.... | ... |  .| |   .....  .||  |||.||. .| .|..|. .  ..  . ||||||..  .     ..|.| |...|
vvnlvehvekkkaqdqdgfahefgllpsd.dgiakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltat

LVDFWRLI--WQekpHVIVMVTNLMEGGRNKCHQYWPDS--DSVYYGPFKVTLIDKQVLPDYTVRELQLILlGSDQPPLMITQYHFTSWPDHGVPEYATS
. |.|||.  |.     .|.|.| ...| ..| .|||.   .|. .|...| |.  . . ||  | |..    ..   . . |... ||.| ||... ..
indlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkq.vkkGetrsvkqfqlqswddmGvqkrpat

ILQFHRRIKNEY---KP---TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
.. . . .|.     .    . .|.||||||||||||.|...   |..  .|  .||   ....|..|  ||.|  
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 460-735 3e-58 192.4 In-house 16-288 (318) alignment
Range on Protein: 460-735
Range on HMM: 16-288/318.0
EqdpeTGQTGYNKQFTVLEQVTQKPDEvTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIE
|    .|.. .....  |....... . .. . . || ||| .  |. |. || |. ..     .|||| |.| |...||.| | .|.  |...||.|. 
e....sGelllseeyerlsrseetvts.lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvW

DINVTAIVMLCQEKENDEEVCYKYWPTEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQ
. | . |||| ||.|.  . . .||| . ..  .|.  ..| .|  .. |. |....... .  || .| ||..| |  .|  .    .| .. . .|.|
eqnsavivmltqeeergkakvhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrteeeesr.qvrqyhytsWpdegvpesgaslldlvrqvskaq

RRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFMLYSN
..||.. ||||||  |||  .|.|  . ... | |...||||. |  | |..  ||| .||. |..... .| |. .. .
qksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd

subfamily_PTPN14_pd Subfamily PTPN14 218-451 4.6e-57 188.3 In-house 39-283 (300) alignment
Range on Protein: 218-451
Range on HMM: 39-283/300.0
HEMTISVSQKNKPLNRFRNVLVYDDNRIILKPlpSHEGcQNDYINASFIDGY--SSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKC
 ... .  ..|.. |||..|| |.|||. |.|  ..|  ...||||| |     .. . ||..|||. .|. |||...|... ..|||.|.  |.|..|.
allstaklpenaeknrfkdvlPyednrvelsp..tken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeks

HQYWPDS----DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQP-PLMITQYhfTSWPDHGVPEYATSILQFHRRIK------NEY---KPTKGPML
..|.|..    ..| .| ||||   ..  . .. . |.|  | | .   ... ||  | ||||||||  .. |.. ....      |.    | .| |.|
fkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
|||||||||||  .  |. ..  |..  ||| ....|.|.|||..||| |
vhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtla

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 463-730 6.2e-57 188.1 In-house 18-286 (319) alignment
Range on Protein: 463-730
Range on HMM: 18-286/319.0
PETGQTGYNKQFTVLEQVTQKpdEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDIN
 .||.|. .|.|  |.. ...  ....    .||.||| .. |. |. ||||.     .. .|||| ..|.|.||..|| . .|.  |. .||.|. . .
astgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeee

VTAIVMLCQEKENDEEVCYKYWPTEATEViFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRS
.  .|||.. .|. .  . ||||.|  |. .|.. ..|..||  . |  | .....|       .|...| | |  ..  .  ...| .|....|.....
ssivvmltklveklkvklkkywpeenfee.yGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt

GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSF
 .  ||||||. |||   |..   .... | |||.|||.. .  |.|..  ||. |||| |.|..  .....
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 189-450 1.2e-54 180.4 In-house 7-265 (439) alignment
Range on Protein: 189-450
Range on HMM: 7-265/439.0
FGEFVADGHANNDEEFMKQYALFHNDLD--KHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHegCQNDYINASFIDGYSSAYRYIATQGPMANTL
| | | . . |..| | . .          . . ..   . ... ||...|  .|  |..|. .|     .  |||| .|.||     |||||||  .| 
fqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyyddklyiatqgpkkett

VDFWRLIWQEKPHVIVMVTNLMEGGRnkchqYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILL-GSDQPPLMITQYHFTSWPDHGVPEYATSILQF
 |||||....|   |||.|||.|  .     ||| .. |.||   |    .  ||.|..| ....    . .    . |.|...|||. ||  |. .|.|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

HRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
 | |.  . |   ||..|||||||||||| .|.|. |.|   |  .||  |.. .|.||  |||. 
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqal

subfamily_Ptp69D_pd Subfamily Ptp69D 467-722 1.3e-54 180.4 In-house 21-281 (307) alignment
Range on Protein: 467-722
Range on HMM: 21-281/307.0
QTGYNKQFTVLEQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAI
. |. | .  ||.  . . . .      |. |||. .  . |..||.||     .. .|||| .. .|||.| ||.|  |. .|. .||.|| . .|| |
dfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLCQEKENDEEVCYKYWPTEaTEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGG----SRHKVVQYQITGWEpNGEV-TCHQAILMILEEMNKTQRR
||| ...| ... | |||| | .|| .|.  .|| .||  . |..|.... .| . .     ..|||||. |||. . .|  . ...| ..|.... .. 
vmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykl

SgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEI
. .. ||||||  ||||..| | .  ....|.|  .|.|.. |  | |..  ||  |||. ..  
n.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyra

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 465-724 2.9e-54 179.1 In-house 18-276 (288) alignment
Range on Protein: 465-724
Range on HMM: 18-276/288.0
TGQTGYNKQFTVLEQVtQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVT
...||..... .| .. .| ..||    ..|..|||  . || | .|| ||.    .. .|||| |.|..|..|..| . .|. .|| .||... . ...
rnrtgfseeynsLaal.ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

AIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKnkmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGN
 |||| .  |.... | .|||.. ... .|.  ..|....  . ...|.....   | ... .. ||| ..|  .|    .. .| .|. .. ..  .  
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvan.qadt

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
  |.||||. |||.  | |. . |.. ..| .|||. ...  | |..  |||..||  |.|.. 
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_PTPRA_pd Subfamily PTPRA 488-726 5.1e-54 178.4 In-house 49-294 (330) alignment
Range on Protein: 488-726
Range on HMM: 49-294/330.0
THNIA--SQNKDKNRSTQFLPPDNHRVVLK---GQ-QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWP
| ..|   .||.|||  . || |  ||.|    |. . .|||| ..| |||.. || |  |   || .||.|| . . ..|||| . || .|| |..|||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

TEATeVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGG---SRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNtSIVVHCSDTVGRSAMFC
.| . | .|.  ... .|..   || | . .... ..    .   | |.  |.|   |  .  . .| .|....|....|.. .||||||  |||.  |.
deGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfi

AAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
.  . ... |.|...|||...|. | |.|  ||| |||. |..... |
vldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_PTPRK_pd Subfamily PTPRK 492-723 5.8e-54 178.0 In-house 40-273 (314) alignment
Range on Protein: 492-723
Range on HMM: 40-273/314.0
ASQNKDKNRSTQFLPPDNHRVVLK---GQ-QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEaTEV
  .|..||||.. |..|..||.|.   |. . .|||| ..||||  .|||..  |. .||..||... | | ..|||| . .|.    |.|||| . |||
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed.tev

iFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHK-VVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRsGNTSIVVHCSDTVGRSAMFCAAATTINK
 .|.  ..|.. ||   .  |.  ...  .| . .. | |.| .||   .  .  ...| .. ...|.|   ..  ||||||   ||. .|.| .. .. 
.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldm

CKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
 ..|||.|||.. |. | .|.  |.| |||| |....
ieregvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_PTPRG_pd Subfamily PTPRG 466-724 6.3e-54 178.1 In-house 17-284 (563) alignment
Range on Protein: 466-724
Range on HMM: 17-284/563.0
GQTGYNKQFT-VLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK---GQQPN--YINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINV
|..|....|  . .....|  ...|  . .|| ||| .. .. |. || |.   |.. .  |||| |.| |.  ||||..  |. .|.  ||.|| . ||
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

TAIVMLCQEKENDEEVCYKYWPTeATEVIFGEYSIKLLNEELYDLYTERTIEIKN-KMKGGSR----HKVVQYQITGWePNGEVTCHQAILMILEEMNKT
. |||. . .|.  . |  |||.  . . .|. ...| .||   |||.||. ||| |.| ...    ..| ||. | | |.  |  |..  .|  . ...
aiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkW.PdhgvPehslpvLifvkkssa

QRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
 ...    ||||||  |||. ....  | ... ..| ...||..||  | |..  ||| |||  ......
ankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall

0037934 (Phosphotyrosine protein) phosphatases II 491-726 4e-53 175.8 In-house 6-241 (243) alignment
Range on Protein: 491-726
Range on HMM: 6-241/243.0
IASQNKDKNRSTQFLPPDNHRVVLKGqqPNYINAVYVDSYKeRkaFIIAESPMFSTVRN----FWKMIEDINVTAIVMLCQEKENDEEVCYKYWPteaTE
.  .|..||| . .|| |. ||.|.|   .|||| ... .. |  .|.   |. .|| .    ||.|. . ..|.||||....|.. | |..|||    |
llpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...ge

VIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRR-------SGNTSIVVHCSDTVGRSAMFCA
| .|.....||.|| .| || ||....|.  ..  . |..|. ..|  .|  . .. .| .|.|... ...       ...  ..||||  |||.....|
vtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

AATTINKCkteGvIDVFQVLKSQRIQKPG-SVQTVEQYKGIFEIVQIY
| . . ..   | .|.....|  | |.|| .||| .||. . |... .
aylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel

0051429 (Phosphotyrosine protein) phosphatases II 258-451 1.4e-52 174.4 In-house 4-212 (272) alignment
Range on Protein: 258-451
Range on HMM: 4-212/272.0
NDYINASFIDGYssaYR------YIATQGPMANTLVDFWRLiWQEKPHVIVMVTNLMEGGRNKCHQYWP------------DSDSVYYGPFKVTLIDKQV
..||||....||   .|      .....||. .|  ||||| .... ..||......| ||.||..|||            .  .. || . |||. ...
sgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYAtsILQFHRRIKNeykptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGID--------
|.||..|||.|.|| | . .......|.|.|||||||. |  .|.. . . .     .||.|||||||..||||. |... |.. ..|  .|        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IISIINRMRQQRMFMVQTRA
.  .....|.||. .||| .
leeaveelraqrpgavqtee

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 229-450 2.1e-52 172.7 In-house 39-263 (287) alignment
Range on Protein: 229-450
Range on HMM: 39-263/287.0
KPLNRFRNVLVYDDNRIILKPLPSHeGcqNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDS-VYY
   ||. .|| .||.|..|   . . |   ||||| .. .|    ..||.|||.| |. ||||......  .....|  .| .|.||..|||. .  .  
vkknryadvlPiddtrvllsaegel.G..sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

GPFKVTLIDKQVL-PDYTVRELQLILLGSDQPpLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-----KPTKGPMLVHCSAGVGRTGTFMAIDMGL
| . |.|.|.... |.|.|| |.|| | . .   .. |... ||||....  | ....|   .|.           ||..||...|.||.|...|. . .
GGysvvlldydikePeygvralrlidletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

QQAEKEGGIDIISIINRMRQQRMFMVQTR
.. |. | .|.  .. |.|..|  .||. 
srledlGrvdvaavvirlreyraalvqav

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 184-452 1.3e-50 166.9 In-house 4-224 (392) alignment
Range on Protein: 184-452
Range on HMM: 4-224/392.0
IPVGKFGEFVADGHAnnDEEFMKQYALFhNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSSAYRYIATQGPMA
||| .|  || . .      |....  .  . | .. |..  . |.. ||..|.| || .|..|. .   .  ..||.|||.|... .   |||.||| |
ipvaqfpafveknrh..salffeefhdl.pgpdiypqtvaqkeinlkknryknilpydsarvklevi..ddipdsdylnasyipsfdnekayiasqgpna

NTLVDFWRLIWQEKPHVIVMVTNLMEGGrnkchqywpdsdsvyygpfkvtlidkqvlpdytvrelqlillgSDQPPLMITQYHFTSWPDHGVPEYATSIL
 .| ||||...||..  |.|||.| ||                                              .    ..|.||| |||..||....|.|
aslddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssll

QFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
.| . .| ..     |...||||||||||  ..||  . .|.|   .|.. ..  .|..| .||||. .
kfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeq

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 466-723 1.9e-50 166.6 In-house 22-275 (315) alignment
Range on Protein: 466-723
Range on HMM: 22-275/315.0
GQTGYNKQFTVLEQVTQKPDEVTHNIasQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTA
 . |.....  .     .| .|...|  .||.|||  . .. |. || |    . .. .|.|| ..| |. .. .| |..|  ..|..||... . ... 
tkngfkqdyesipggqlhpldvakki..enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigk

IVMLCQEKENDEEVCYKYWPTEatEVIFGEYSIKLLNEELYDLYTERTIeikNKMKGGSRHKVVQYQITGWePNGEVTCHQAILMILEEMNKTQRRSGNT
|||| .  |.... . |||| .  .||.|.... . .|| .. || ||.     . |   ..|||...| | |. .|. .   || |    |  . .  .
ivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytsw.pdmgvpkytiplmnlirtvkqhhtnsvg

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
.||||||. |||.  |..  . ... ..| .|||.....  | .. . ||..|||. |....
aivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal

subfamily_PTPN6_pd Subfamily PTPN6 455-728 3.3e-50 165.8 In-house 13-298 (306) alignment
Range on Protein: 455-728
Range on HMM: 13-298/306.0
IGKLSEQDPETGQTGYNKQFTVLEQV-TQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK-GQQ--PNYINAVYVD--SYKERKAFIIAESPMFSTVR
. .|.... .....|....|  |.|  ..|  . ..    .|| |||    || |. ||.||  .    .|||| |..  . ...|..| ..  . .|| 
vselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvs

NFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMIL
.||.|. . | . |||. .| |  .| |..|||.| ..  .|..|.. ..|.  . |. |.. ...| |... ..|.||. . |  .|  .  .|.|  |
dFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfl

EEMNKTQRRSG---NTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
|..|. |...    . .||||||. .||   |    . ... ...|.   ||. .. || | |. | ||| .||| ...... |..
edvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

subfamily_CG7180_pd Subfamily CG7180 206-449 2.2e-49 162.7 In-house 20-275 (296) alignment
Range on Protein: 206-449
Range on HMM: 20-275/296.0
KQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVT
|.     . |.  .    . ..|.  ||  .|. || ||..|. |  .|  ..|||||...|..     || |..|. .|. .||||...|. . .|..|
klelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGee..ksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

NLMEGGRnKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLILL---------GSDQPPLMITQYHFTSWPD-HGVPEYATSILQFHRRIKN----
. ..  . ....|||      ||.. | .. .. ... . |...|            . . .  .......| |.  . ||  ....... ||..     
ktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrek

-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQT
 . .|..||..|..| |..|.| ..|||. |...|||. .|.   . ..|..|  .|..
vdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLven

subfamily_PTPN12_pd Subfamily PTPN12 464-727 2.5e-49 162.7 In-house 4-277 (290) alignment
Range on Protein: 464-727
Range on HMM: 4-277/290.0
ETGQTGYNKQFTVLEQVTQKP--DE---VTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMI
..|.  ..|.|. | ....|   ..    ..  ...|. |||    || |. ||.|. ..     .|||| ..   ......| | .|.  |. .||.||
kegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmi

EDINVTAIVMLCQEKENDEEVCYKYWPTEATEVI-FGEYSIKLLNEELYD-LYTERTIEIKNKmkgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMN
 . ||. .||.|.| |..   | .||| |  | . |||....| .|.  |  .. ||......   . ..|| |.. | |   |  . .. .| ..|...
weknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvr

KTQRrSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGV---IDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
..|. | .. .|||||  |||    .|   . .  |.| .   .|||... . | |..  ||| |||. ... |  ..
elqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 491-728 5e-49 161.8 In-house 40-278 (315) alignment
Range on Protein: 491-728
Range on HMM: 40-278/315.0
IASQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT-EAT
  ..|  |||    || |. ||.|    .  . .|||| |. |... ||.| .  |  ..| .||.|. . .||.|||. . .|.|   | .|||  .| 
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

EVIFGEYSIKLLNEELYDLYTERTIEIKnkmKGGSRHKVVQYQITGWEPNGEVTcHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTIN
 | ||.....||. |     . | . ..   |. . ..| |.| |.|  .|    ... |. |    |..... . |..||||  |||. .....   ..
svefGsikvellsleadtdgvarklvtr...kseesrtvtqfqftewPdkGvdk.qtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevva

KCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
. | . ..|||...|  | ..|  ||| |.|  |...|. .| 
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

0041856 (Phosphotyrosine protein) phosphatases II 228-450 1.7e-48 160.0 In-house 1-157 (182) alignment
Range on Protein: 228-450
Range on HMM: 1-157/182.0
NKPLNRFRNVLVYDDNRiilkplpshegcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTnlmeggrnkCHQYWPdsdsvyy
|...||....| || .|             .|||||....|.  | |.||||||. .|. ||.|...... ..||..|         ...|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

gpfkvtlidkqvlpdytvrelqlillgsDQPPLMITQYHFTSWPDHGVPEyATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQaeke
                            .  . ...||....|||||||.   ..|.| .....     .|| |||||||||||||. |... ...    
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....

gGIDIISIINRMRQQRMFMVQTR
 |... .... .|..|. ||.| 
.gvsleeavklvrsrRpgmvitp

subfamily_CG7180_pd Subfamily CG7180 484-726 3.6e-48 158.7 In-house 31-289 (296) alignment
Range on Protein: 484-726
Range on HMM: 31-289/296.0
PDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK---G-QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEeVCYKY
 ..  ... ..|..|||  . .|.|. ||||.   | .. .|||||||||.   |..|. | |. .|| .||... | .. |.|.|... .  .  . .|
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPTEAtEVIFGEYSIKLLNEELYDLYTERTIEIKNK-------MKGGS--RHKVVQYQITGWEPNGEVTCH-QAILMILEE----MNKTQRRSGNTSIVV
|| .. .  .||  .....|. |   . ||. .. |       .|. .     | ..|.| || . .|    .|.. ...     ..|.. .  .  .||
wpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvv

HCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
..|| ..|| ...|.  .... . |. .|||. .|  |...|. |..||.|| |..... .
vssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 461-729 3.7e-48 159.1 In-house 8-278 (281) alignment
Range on Protein: 461-729
Range on HMM: 8-278/281.0
QDPETGQTGYNKQFTVLEQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIED
|  .  ..|. .... |... .. .  |   | .|. ||| .     |. ||..    . .. .|||| .|..||. |..|....|. ... .||.|. .
qlsqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvwe

INVTAIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIknKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQR
 .|.||||. .| |..   |..||| ...|...|.. .| ..||    | ||....  ....|   .|.| . | |  .|  .  ...|   .|..|...
qkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlklte

RSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDS
.. ....|.|||  |||.  . |  . ......|   .|| .|... | ..   |||| ||. .. .|  .|| 
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_PTPRB_pd Subfamily PTPRB 467-727 4.4e-48 158.8 In-house 24-285 (293) alignment
Range on Protein: 467-727
Range on HMM: 24-285/293.0
QTGYNKQFTVLEQVTQKPdEVTHNIASQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAI
........  |..| ..  .|. . ...|..||| |. || |. || |    . .. .|||| |.. |. .. || .  |. .|| .||.|. . ....|
dlrfseeyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssii

VMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNkmkGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQ-RRSGNT
||| |  |.  . | .|||.. ..|..|. ...|..|| .. .. |...|..   . ...|| ||. | |   |     ...| ......... . . ..
vmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

SIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
 ||||||  |||.  | |  . ... ..| ..|.| .. . | ..   |||..||  | . |. .|
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 493-727 1.2e-47 157.1 In-house 41-276 (515) alignment
Range on Protein: 493-727
Range on HMM: 41-276/515.0
SQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT-EATEV
  |  |||    || |. || |       . .|.|| |. |..  ||.| .  |  ..| .||... . |||.|.|. . ||.|   | ||||   .  |
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

IFGEYSIKLLNEELYDLYTERTIEIknkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMnKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKC
 ||.....|.  |     . |....   .||   . | |.. |.|  .|     ...| .. |. |...   . ....|||  |||  .....   . . 
kfGsikvelvsleactggikrkltv...lkgddsrtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvaha

KTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
||  ..|||....  | ..|  ||| |||  |...|. .|
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_PTPN23_pd Subfamily PTPN23 464-724 1.6e-46 153.4 In-house 11-277 (288) alignment
Range on Protein: 464-724
Range on HMM: 11-277/288.0
ETGQTGYNKQFTVLEQVTQKP-DEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKE-RKAFIIAESPMFSTVRNFWKMIEDINVTA
  |.|. .|.|  |||  .|   . .  ||  . .||||.  || |. ||.|.|.. .|||| .| .       ||.. .|. ||.  ||.|. .  .  
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLCQEKENDEEVCYKYWPTEATE-VIFGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNK---TQRR
|||| ...| ... . .|||..  | | ||..|. | ...  . . ||..... . .    ..|.  |.| |   |     . .| .|.|...   ...|
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqr

SGNTSIVVHCSDTVGRSAMFCAAATTINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
  .| .|||||  |||. .|.   . ... .  .|..|. ||..  | |.  .||..||.|  .|.| 
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 483-729 3.5e-46 152.7 In-house 35-286 (297) alignment
Range on Protein: 483-729
Range on HMM: 35-286/297.0
KPDE-VTHNIASQNK---DKNRSTQFLPPDNHRVVLKGQQPN----YINAVYVDSYKErkAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEe
 |   .. .  ...|   .|.| .  || |  || |.  . .    |.|| .| ..|.   .|  . || .|| .||.|. | .|..|||| ...|.|. 
lpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.

VCYKYWPTEATEViFGEYSIKLLNEELYDLYTERTIEIKnKMKGGSRHKVVQYQITGWEPNGEVT--CHQAILMILEEMNKTQRRSGNTSIVVHCSDTVG
 | .||. ...   ||. |..||  .    . .|..|.. | |  .|. | ||| . |  . .      ...| ...|..|.     .. ..|||.  ||
kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevt.kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvG

RSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDS
| .....    . . | |  .|.|...|  | ..|  ||| |||| ....|  .| |
rtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls

0036282 (Phosphotyrosine protein) phosphatases II 258-450 1.4e-45 150.4 In-house 2-156 (174) alignment
Range on Protein: 258-450
Range on HMM: 2-156/174.0
NDYINASFIDGYSSAYRYIATQGPMAntlvdFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDsdsvyygpfkvtlidkqvlpdytvrelqlillGSDQ
.||||||..|..    |.||.|||.|     ||....... ...||.....| |. ||..|||.                                 .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

PPLMITQYHFTSWPDHGVPEYATsILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAIDMGLQQAEkEGGIDIISIINRMRQQRMFMVQTR
.  .. ||... |||||||. .. .|.| ..... ..   .||.|||||||||||||..|... |.. . |. .|..... ..|.||. |||| 
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 465-724 1.3e-44 147.6 In-house 20-285 (325) alignment
Range on Protein: 465-724
Range on HMM: 20-285/325.0
TGQTGYNKQFTVLEQVTQKPdeVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQ----QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINvT
  | |. ..| .|  .  .    .     .||.|||    .. |. ||||. .    . .|||| |. ..|... |. | .|. .|. ..|... | . .
qdqdgfahefgllpsddgia..kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.c

AIVMLCQEKENDEEVCYKYWPTE-ATEVIFGEYSIKLLNEELYDLYTERTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNK---TQR
..|..  | ..... | .||| | .  . ||   .||   | .  |  | ...|.  |.|    | |.|. .|.  |      ... ||. ...   . .
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqv.kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

R--SGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQ
    . | |.||||. |||. .| .  . ..|  .|  .|.|...|  | ..|  |.||.||  |.| . 
antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 468-723 3.8e-44 145.7 In-house 6-255 (267) alignment
Range on Protein: 468-723
Range on HMM: 6-255/267.0
TGYNKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQ
. ..|.|  .......   ..  ||..|...||  . || |. ||.|. .. .|||| ||..|| ..|||. . |.  |. .|...| | .|. ||.| .
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

EKEndEEVCyKYWPTE-ATEVIFGEYSIKLLNEELYDLYTERTIEIknKMKGGSRHKVVQYQITGWEPNGEVTCHQAILmiLEEMNKTQRRSGNTSIVVH
  .  ...  ..|| . .    . . ...   |.  . |   |.|.  |.|  | |.|. |    |. | .   .   |  .  . | |   ||  .||.
vft..dnir.lfwPPkmgqakkyqdltvehslekeendyqiitlel..kfknesahnvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvva

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
||| ||||  |  . . ... ||||| |.|. |.  | |..| |.| |.|  | |..
csdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 466-721 4.6e-44 146.0 In-house 32-285 (319) alignment
Range on Protein: 466-721
Range on HMM: 32-285/319.0
GQTGYNKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQ----QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTA
 .| .. .|  . ... .  . |.    ||||||| .. |. |. .| |.        .|||| .|. |. .. .| |  |.  |. .||.|| . |...
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IVMLCqekendEEVCYKYWPTEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEE-MNKTQRRSGN
||.|       .. | .||| .. .   ... .|.   |  . |. | ||. .. |     |. |. . ||   |       ......     |..  ..
ivllt......kdkcsqywplkivi.keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

TSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
..||||||  |||. .. .  . ... | |  .||.....  | |..  || . ||| |. 
anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 188-452 5.6e-44 144.9 In-house 13-271 (290) alignment
Range on Protein: 188-452
Range on HMM: 13-271/290.0
KFGEFVADGHANNDEEFMKQYALFHND-LDKHEMTISVSQKNK--PLNRFRNVLVYDDNRIILKplpshEGCQNDYINASFIDGYSSAyrYIATQGPMAN
 | .| .|    | .|. |.|       |  . .  .. .||     ||...|   |  |.|||     .| . ||. | ...|  .   .| |||....
afekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk.....dGydGdyvhanyvkGlkam..filtqGalkd

TLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSD--SVYYGPFKVTLIDKQvLPDYTVRELQLILLGSDQP-PLMITQYHFTSWPDHGVPEYATS
| .|.||.. |||  .|||. .|.| |. ||.||.|. .   . .| . |.   ..  .|  .    | .   |.    ..  ..  ||||. |.  . .
tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseed.dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstla

ILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
.|.  | ...    . ||. ||||||.||||||.||..|||   .   .|.. ..  .|. |.  ||   .
llrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiq

0049772 (Phosphotyrosine protein) phosphatases II 189-444 1e-43 145.6 In-house 9-255 (314) alignment
Range on Protein: 189-444
Range on HMM: 9-255/314.0
FGEFVAdgHANNDEEFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDdNRIILkPLPSHEGcqNDYINASFIDGYssaYRYIATQGPMANTLVD
|.|.    | .  .....   . .. | .. ....   .|.  ||. ..| .| || || |  ...|   ||||||..||.    ..||||||. .|.||
fselli..hddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsg..sdyinasyvdgf...lkfIatqgpleitvvd

F----------WRLI--WQEKPHVIVM---------------------VTNLMEGGrnkchQYWPDSDSVYYGpfkvtlidkqvlpdY-------Tvrel
|          ||..  .. ....|||                      ..|...|      ... .|  ..                            
freepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk..............eelydpelf....

qlillgsdqpPLMITQYHFTSWPDHGVPeYATSILQFHRRIKNEykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAekegGIDIISIINRMRQQRM
          . .. .|. . .||...|     ...| . |..   ...|| ||||.||.||||||..... . .     |...  .....|..|.
..........erlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRp

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 485-721 1.1e-43 144.8 In-house 15-249 (284) alignment
Range on Protein: 485-721
Range on HMM: 15-249/284.0
DEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQ----QPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCqekendEEVCYKYW
 . |.    ||||||| .. |. |. .| |.        .|||| ..  |. .. .| .  |.  |. .||.|| . |...||.|       .. | .||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PTEATEvIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEE-MNKTQRRSGNTSIVVHCSDTVGRSAMFCA
| .. .   ... .|.   |  . |. | ||. .. |     |. |. . ||   |       ......     |..  ....||||||  |||. .. .
plkivi.keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
  . ... | |  .||.....  | |..  || . ||| |. 
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

0043147 (Phosphotyrosine protein) phosphatases II 258-450 1.7e-42 140.4 In-house 5-147 (172) alignment
Range on Protein: 258-450
Range on HMM: 5-147/172.0
NDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLmeggrnkchqywpdsdsvyygpfkvtlidkqvlpdytvrelqliLLGSDQ
.||||||..|.|    |.||||||. ||| ||||...... ..||..|.|                                            |.  ..
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpel

PPLMITQYHFTSWPDHGVPeYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRMFMVQTR
   .. ||....|||||||  .  .|.| . |..   .  .||.|||||||||||||. |... |       |...  ... .|..|. .||. 
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

0046846 (Phosphotyrosine protein) phosphatases II 254-450 2.1e-42 140.2 In-house 8-159 (176) alignment
Range on Protein: 254-450
Range on HMM: 8-159/176.0
EGCQNDYINASFIDGYssayRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYgpfkvtlidkqvlpdytvrelqlill
..   |||||..|.|.    |.||||||. .|| ||........ ...|..|...| || ||..|||.  .. .                          
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

gsdqpplmitQYHFTSWPDHGVPEYaTSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFMAIDmglqQAEKEGGIDIISIINRMRQQRM-FMVQTR
          ||... |||||||.. . .|.. . |.. .|   || |||||||.|||||. |..      |.| |...  .. ..|.||. ..|||.
..........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

subfamily_PTPN9_pd Subfamily PTPN9 462-722 2.7e-42 139.8 In-house 10-285 (297) alignment
Range on Protein: 462-722
Range on HMM: 10-285/297.0
DPETGQTGYNKQFTVLEQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDI
  |.|. |  |... . . . .  ....     |  ||| |  |  |. ||||.     .. .|||| .|| ||..|||| .  |.  ||..||.|. . 
vkekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeq

NVTAIVMLCQEKENDEEVCYKYWP-TEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQR
.|  |||  .  |.    | .||| .| .   ||..|.. .. | .. |..|..||||  .. || ||. .|...|   |     ...| .||.. ..| 
evlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesr.kvthfqflsWPdyGvPssaaslldvlekvrekqa

RS------------GNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEI
 .             .  ||||||  .||.  |..   .... ...|..||....|  | |.  |.|| |||.  .  
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 493-728 1.3e-41 137.6 In-house 26-269 (274) alignment
Range on Protein: 493-728
Range on HMM: 26-269/274.0
SQNKDKNRSTQFLPPDNHRVVLKGQQ-----PNYINAVYVDSYK-ERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATE
. .. ||| .. || .| ||.|. ..      .|||| |.  |. | ||.. .  |. .|| .||.||   .|. |||| . ||..|. | .|.|..   
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

VI---FGEYSIKLLNEELYDLYTERTIEIKNKMKggsRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNT--SIVVHCSDTVGRSAMFCAAA
 |   .|. .||  .    . |. |.. .|.  .   ...|. |  | |  .      ...| ...|........ .   ..|||||  .||  .| |. 
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

TTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
 .... . |.|.||...    |... | ||| |||. |....  || 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

0049260 (Phosphotyrosine protein) phosphatases II 265-450 2.4e-41 136.3 In-house 1-136 (152) alignment
Range on Protein: 265-450
Range on HMM: 1-136/152.0
FIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWpdsdsvyygpfkvtlidkqvlpdytvrelqlillgsdqpplmitQ
|||||   ...||||||. ||| ||||.... . ..|||.|.|.| |. ||.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLqqaekeGGIDIISIINRMRQQRMFMVQTR
|... |||||||. .  .|.... |.  ..  .|| |||||||||||||..|... |       |...  .....|..|. .|.. 
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnp

subfamily_PTPN3_pd Subfamily PTPN3 486-728 3.9e-41 135.8 In-house 30-277 (280) alignment
Range on Protein: 486-728
Range on HMM: 30-277/280.0
E--VTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDS----YKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKY
.  ...   ..| .|||    || |. || || .. .|||| ||.      .  . .|..  |. .|. .||.|. . ... |||| .  |.    |..|
glaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKtQRRSGNTSIVVHCSDTVGRSAMFCA
||..  |. .||.|.|. .|.    |  | . .|.| .  .| |..| | . |  .|  . .. .| ..|...| .|.. .. .|||||  .||. .. .
WPetedeleygefsvkcekedetksyvlrelvlkdketkeer.kilqlqylaWpdhgvPddsadflefvervrk.lrsgkeePvvvhCsaGigrtGvlil

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE-IVQIYLD
  |.. .  ..  . . ....  | |.   |||..||| . | |...| .
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 494-727 1.1e-40 134.2 In-house 37-277 (287) alignment
Range on Protein: 494-727
Range on HMM: 37-277/287.0
QNKDKNRSTQFLPPDNHRVVLK--GQQ-PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIFG
 .  ||| .. || |. ||.|   |..  .|||| || ||.. .||| | .|. .|||.||... . ........ .| |.    ||||||     .  |
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EYSIKLLNEELY-DLYTERTIEIKNkMKGGSRHKVVQYQITGWePNGEVTCH--QAILMILEE---MNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTI
 ||. ||. .     |. |.. . . ...   . | |...  | |.. ..      | ..|.    .. ..  |.   .|||..  .||| .. |  . .
GysvvlldydikePeygvralrlid.letrearvvkqldllsw.PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

NKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
.. .  | .|| .|.   | .. . ||.| |.. ..| .  | 
srledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 491-728 6.5e-40 131.8 In-house 16-265 (270) alignment
Range on Protein: 491-728
Range on HMM: 16-265/270.0
IASQNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSY-KERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEAT
 | ..|  ||... ||  . ||.|.     .. .|||| ||  . .|.|..| | .|. .|...||.|| . .||||||. . .|.  . | .|||.|. 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

E---VIFGEYSIKLLNEELYDLYTERTIEIKnkmKGGSRHKVVQYQITGWEPNGEVTCHQ------AILMILEEMNKTQRRSGN-TSIVVHCSDTVGRSA
|   . .|. ..  |.||  . |  . ....   . |.....| .. . |  .| .. ..       .| .|... .....  . . ..||||. |||. 
ekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

MFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
.. |  ....  .... .|| ....  | ...  ||..|||. ... |..| .
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 216-452 8.9e-40 131.4 In-house 21-247 (267) alignment
Range on Protein: 216-452
Range on HMM: 21-247/267.0
DKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLmegGRNKC
..  .. |...||.  ||. ..| |||.|.||.        ...|||||...||     .|.||.|. ||  ||. .| ..|  |||..|.    . .. 
tsstisqsiaeknqernrlddnlpyddtrvilr......tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdni

HQYWPDS--DSVYYGPFKVTLIDKQVLPDYTVRELQLILlgSDQPPLMITQYHFTSWPDHGVPE-YATSIlqFHRRIKNEYKPTKGPMLVHCSAGVGRTG
...||    ..  |  . |    ..   || .  |.| .   ..    .| |..  |      . |   .  |    ||. .    |..|.||.||||.|
rlfwPPkmgqakkyqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnintnnkpylkpl..fgilaknqlengnrPlvvacsdGvGrsG

TFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRAR
||. ||  |..| .||  ||   . ..|.||. .|.|. |
tflvidsqleraktegvsdifdflrkirsqriglvdtker

subfamily_PTPN1_pd Subfamily PTPN1 478-717 1.2e-39 130.8 In-house 13-261 (290) alignment
Range on Protein: 478-717
Range on HMM: 13-261/290.0
EQVTQKPDEVTHN--IASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEV
...... ......     .|...||     | |  |..|. .. .||||  |.  . .. .|..  |. .||  ||.|. . .  |.||| .  |...  
ldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CYKYWPTEAT--EVIFG--EYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGN-TSIVVHCSDT
|..|||..    |...   ....||..|| .. || |..|..|.    .| .....  | |   |   . .| |  | .. ..   | .    |.|||  
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetr.eilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

VGRSAMFCAAATTIN---KCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYK
.|||  || . | .    | .    .|. .||   | .. | .|| .| .
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlr

subfamily_PTPN13_pd Subfamily PTPN13 471-723 3.6e-39 129.7 In-house 14-265 (273) alignment
Range on Protein: 471-723
Range on HMM: 14-265/273.0
NKQFTVLEQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPnYINAVYVD--SYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQE
...|. |...  . |...     .||||||  . || |. || |... . |||| ..     |..  .|..  |.  ||..||.|. . ... |.|. .|
aeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

KENDEEVCYKYWPTEATEVI--FGEYSIKLLNEELYDLYTERTIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrsGNTSIVVH
||...  | .||| .. . .   . . ..||. . .| .. |....|..  | | ..|.. . . |   |  .  . .| .. |... |.   .. ||||
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvh

CSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
||  .||| .. .  . ..  . .  .|| ..... | |. | ||| .||  .....
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 212-452 4.8e-38 125.6 In-house 34-275 (305) alignment
Range on Protein: 212-452
Range on HMM: 34-275/305.0
HNDLDKHEMTISVsqKNKPLNRFRNVLVYDDNRIILKPLPSHegcqnDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGG
 ||..| .       ...  ||...|   |.||. |..   |     .|| | ..   . . |.| || |. .|  ||| . .|.| . | |. ||.| |
fndfekmkafkea..qeagknrykdvgcldnnrvklegpwph.....eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekg

RNKCHQYWPDSD--SVYY--GPFKVTLI-------DKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRriknEYKPTKGPM
 .||..|..  |   . .  .  |...        . .   . .|.| .|.. |. .  . .|.||.  ||| |||   ..||..      . .|.|||.
akkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle....karpskgpi

LVHCSAGVGRTGTFMAIDMGLQQAEKEGGID-IISIINRMRQQRMFMVQTRAR
 ||||||.||||. . ..  |.|      |.    |....|.||   .|| |.
vvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaq

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 218-454 1.3e-37 124.5 In-house 31-267 (307) alignment
Range on Protein: 218-454
Range on HMM: 31-267/307.0
HEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpsHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQ
. .|.   . |   ||...| . | .||..|     .|   ||| | ..       ..|..|||. ||  .|| .. |||   ..|. ...| .. ||.|
egvtveafsantdknryqdvkcqdkgrivvk....fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceq

YWPDSD--SVYYG--PFKVT---LIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGR
|||  .     .|  |  ..   |  |.. ||  . ..  . .   |    |... .. |||.|||.   . . .   .. .    . |..|||||||||
ywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhcsaGvGr

TGTFMAIDMGLQQ-AEKEGGIDIISIINRMRQQRMFMVQTRARSM
.|| .|| .  ..  . .   |.  ... .|.|| . .|| |. .
sGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyl

subfamily_PTPRN_pd Subfamily PTPRN 471-723 1.4e-36 120.8 In-house 32-288 (297) alignment
Range on Protein: 471-723
Range on HMM: 32-288/297.0
NKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQ----QPNYINAVYVDSYKER-KAFIIAESPMFSTVRNFWKMIEDINVTAIVML
.|..  | .  ..|   .   | .| .||||...|| |. || || .    . .||||  .     |  |.| ...|. ||| .||.|. .  |. ||.|
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

CQEKENDEEVCYKYWPTEATEViFGEYSIKLLNEELY-DLYTERTIEIKNKMKGGSRhKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRsGNTSIV
.. .|.. . |..||| | .|| .. | ..|. | .. | |  |.. .||  .  .|  | |.    |. .|  .  ...|     .||. |    ..||
trleeegvkqckrywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetr.tvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpiv

VHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
||||| .||. ....    .|.  |    ||.   |.  | |.|| |.| .|.. ..  |
vhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav

0051082 (Phosphotyrosine protein) phosphatases II 258-451 5.1e-36 118.9 In-house 3-140 (151) alignment
Range on Protein: 258-451
Range on HMM: 3-140/151.0
NDYINASFIDGYssayrYIATQGPMAntlvDFWRLIWQEKPHVIVMVTNLMEGGrnKCHQYWPDSDsvyygpfkvtlidkqvlpdytvrelqlillgsdq
.||||.|...|.     .....||.|    ||..|.....  .||......| |  .|..|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

ppLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekeggIDIISIINRMRQQRMFMVQTRA
  . ........|||.|.|..  ..|.|.. . .   . .||.|||||||.|||||..|... |..      ... .... .|..|. .||.  
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 221-451 5.9e-36 118.9 In-house 28-257 (285) alignment
Range on Protein: 221-451
Range on HMM: 28-257/285.0
TISVSQKNKPLNRFRNVLVYDDNRIILKplpSHegcQNDYINASFIDGYS-SAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYW
| .  . |  |||. .| . .. |..||    |   . ||| ||..         ||.||||. .|| |||..|.|||   ..|.  |.||| .||  |.
tytayeanpdlnryadvrcieetrvvlk...nh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PDS--DSVYYGPFKVTLIDK--QVLPDYTVRELQLILLG-SDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeYKPTKGPMLVHCSAGVGRTGTF
|.   . | .| ...|| .   . .    .  | .|    .   || . . .   |||.  || |  ...... .|.  .| . |. |||||||||| ||
peklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatf

MAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
. ||    .  ..  |... |.  ||  |.  ||.. 
vgidyatirimenpniemldivremramrfqavqshm

0044763 (Phosphotyrosine protein) phosphatases II 240-450 1.2e-35 118.2 In-house 2-157 (178) alignment
Range on Protein: 240-450
Range on HMM: 2-157/178.0
YDDNRIILKPLPSHEGcqNDYINASFIDGYssayRYIATQGPmantlVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSvyygpfkvtlidkqv
.|..| .| .|. .|.   ||||||.|...     |.....|     .|...|..... ..||..|. .|.|..||..|||.. .               
ldrtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

lpdytvrelqlillgsdqpplmiTQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQaekegGIDIISIINRM
                        ||... .||||||.    .|.|.. |.. ... .|| ||||||||||.||..|... ...     |... ..|...
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielv

RQQRMfMVQTR
|..|. .|...
rerRp.ivpnp

0051429 (Phosphotyrosine protein) phosphatases II 519-731 1.2e-35 118.8 In-house 4-229 (272) alignment
Range on Protein: 519-731
Range on HMM: 4-229/272.0
PNYINAVYVDSYKE---RKAFIIAESPMFSTVRNFWKMiEDINVTAIVMLCQEKENDEEVCYKYWP-----------TEATEVIFGEYSIKLLNEELYDL
..|||| .|. |     ..... .  |.  |...||.. .. ....||.|..| | . . |..|||           ..|... .| ....|| |||.. 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTchQAILMILEEMNKtqrrsgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID--------VF
|. |......... |  ..| ... |.|   |  .  .|.| .||....      .  ..||||  ..|.....|.   .     | ..|        ..
yilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLDSFM
....  | | ||.||| |||. ..|... .|.|..
eaveelraqrpgavqteeqylflyeallellrsll

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 210-454 1.6e-35 117.2 In-house 19-259 (281) alignment
Range on Protein: 210-454
Range on HMM: 19-259/281.0
LFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKP-LPSHEgcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLM
 .  |      |.     |.  ||. |. . |  |. ||  .| ..    ||| | .|        || ||||  .|  ||||.||||.   |||. ...
nlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnkn..stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfl

EGGRNKCHQYWPDSDS--VYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSA
|  |.|| .|.|      . .  . |.  |  |        |.|   |  .   .||.. .  |||  ||| .  .|.  |.|.        | ..||||
etnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetr...lithwlwkewpdwqvpessevmlkilrkirarst....ppvihcsa

GVGRTGTFMAIDMGLQQAEKEGGI-DIISIINRMRQ-QRMFMVQTRARSM
||||.||.||... ||       . ||  |. ..|   |   |||  . |
gvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqym

subfamily_ptpA1_pd Subfamily ptpA1 208-417 6.2e-35 115.7 In-house 27-249 (418) alignment
Range on Protein: 208-417
Range on HMM: 27-249/418.0
YALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGcqNDYINASFIDGYSsAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNL
. |. . .   | .    ..|   ||. |.|  .  |. || .  .||  .||||| .|||     ..|.||||. ||. ||||..|... ..|||..  
frlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkeg..sdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsre

MEGGRNKCHQYWPDS-----DSVY------YGPFKVTLIDKQVLPDYTV--RELQLILLGSDQpplMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY-
 |  | || .|||.       |.|      .| . | |..    |.  .  |...| . |  .    ||||..  |||| .|...  . |. . | |   
sencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetr...ditqyqyegwpdhnipdhtqpfrqllhsitnrqn

--KPT---KGPMLVHCSAGVGRTGTFMAI
   |.   . |..||||||||||||| . 
qiipssdrnvpiivhcsagvgrtgtfcta

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 494-721 8.5e-35 115.1 In-house 2-233 (237) alignment
Range on Protein: 494-721
Range on HMM: 2-233/237.0
QNKDKNRSTQFLPPDNHRVVLKGQ--QPNYINAVYVDSYKE-RKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIFG
.|| |||  .    |  ||||||   . .|||| |....    | .| |. |. |.  .||.|. . . . ||||    |..|. |.||||       .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

EYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEM-NKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 ... |  .| .  || |.. . ....      . |||.| |  .|      |.| .  .. |...  |  .  ..|||  |||...|    . . ..| 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

EGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
. |.|... ..|   ..|  .|| .||  |..
kkvvdiynyvysieedrpyiiqtkdqyvfihq

0036282 (Phosphotyrosine protein) phosphatases II 520-720 8.9e-35 115.3 In-house 3-163 (174) alignment
Range on Protein: 520-720
Range on HMM: 3-163/174.0
NYINAVYVDSYKERKAFIIAESPMFstvrnFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTeatevifgeysikllneelydlytertieiknkMKGG
.|||| ..| .   . .|.   |.      ||.|. . ..|..|||..|||.. . |. |||.                                 ..  
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lred

SRHKVVQYQITGWEPNGEVTCHQaILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKSQRIQKPGSVQTVEQYKGI
 .. ..||. ..|. .|. . .. .| ....... . ....  ..||||  |||.....||   .   . |...|........| |.||.||| .||. .
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

F
 
y

subfamily_PTPN14_pd Subfamily PTPN14 472-728 2.2e-34 113.8 In-house 24-297 (300) alignment
Range on Protein: 472-728
Range on HMM: 24-297/300.0
KQFTVLEQVTQKPDEVTHNIAS--QNKDKNRSTQFLPPDNHRVVLKGQQ---PNYINAVYVDS--YKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVM
| ||  |....|  . . . |.  .|..|||  ..|| .. || |. ..    .||||  .      ... .|.| .|.  ||..||.|. . .|. |||
kvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LCQEKENDEEVCYKYWPTE---ATEVIFGEYSIKLLNEELYDLYTERTIEIKNkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNT
| .|.|.  | ..||.| .   . .| ||.. .     |  | .. .....|  .  . . .|.  | | |  .|     .  |  |||..  .|.. ..
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkh.lpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnse

S--------IVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYLD
.        ..||||. |||. .   .   |.  ... .||. .||.  | |.   |||. ||| .....  ||.
veskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 362-615 2.1e-33 110.3 In-house 91-314 (440) alignment
Range on Protein: 362-615
Range on HMM: 91-314/440.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKN-EYKPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRARSMIgkLSE
. |||. .|||.|||..|  .|.. . ... . |  .||.|||||||.||||  .|.|  |..|..   |||.|.|| ||..|  ||||  .  .  . |
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf..vhe

QDPETGQTGynkQFTVLEqvtqkpDEVThniasqnkdkNRSTQFLPPDNHRVVLKGQQPnyinavyVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVT
   |   .|   .  .||      |..|          .|  |   |. |      ||        .. |  ..||| .. |. ||| .||... | ...
avlegllcg...dtlile......ddit..........erveqiqwpnphtdksplqqe.......fegyskknafiatqmpldstvldfwrlvhdyris

AIVMLCQEkeNDeEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNK
.|.|| |   ||   |  ||| ..  | || ...     |  .    ||.|.| |
tiimlnql..nd.ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk

0041856 (Phosphotyrosine protein) phosphatases II 495-723 9.8e-33 108.7 In-house 1-167 (182) alignment
Range on Protein: 495-723
Range on HMM: 1-167/182.0
NKDKNRSTQFLPPDNHRvvlkgqQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCqekendeevCYKYWPTEAtevifgeysi
|.|||| . .||.|. |       ..|||| .....   . ||..  |. ||| .|..|. . ..|.||.|.         .. |||..           
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell..........

kllneelydlytertieiknkmkggsRHKVVQYQITGWEPNGEVTcHQAILMILEEMNKtqrrsGNTSIVVHCSDTVGRSAMFCAAATTINKckteGvID
                           . ..||. ..|. .|  .  . .| ..||...      .  ..||||  |||.....||   . .    | ..
..........................erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vs

VFQVLKSQRIQKPGSVQTVEQYKGIFEIV
.....|  | ..||.|.| .||  .  ..
leeavklvrsrRpgmvitpnqyfflqlal

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 220-386 1.7e-32 107.5 In-house 23-190 (297) alignment
Range on Protein: 220-386
Range on HMM: 23-190/297.0
MTISVSQKNKP--LNRFRNVLVYDDNRIILKPLPShegcQNDYINASFID--GYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKC
 . |....|     ||.|..| .||.|. |.  ..    ..||||| ..      . ..|| .|||. .|. |||.|....   |||||..| |.||.||
esfssakrnsslrknryrdilatddtrvkllrvit....erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

HQYWPDSDSV--YYGPFKVTLIDKQvLPDY---TVRELQLILLgsdQPPLMITQYHFTSWPDHGVPEYATSILQFH
  |||...      | . |  . .    ..    . |||||     .   ...   | ||||||||     . .|.
apywpsvvqerlkagdvvveflsst.sdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfq

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 202-453 7.6e-32 105.1 In-house 27-279 (310) alignment
Range on Protein: 202-453
Range on HMM: 27-279/310.0
EEFMKQYALFHNDLDKhEMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPShegCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVI
| ..|||  .  . |   .|    .|.   ||. .|.. |. |. ||   |     .||| | ..        .| .|||.  |..||||.|.||.   |
eglvkqyrkldakqds.sltyeaykkymhknrysdvvcldtsrvklkidks...ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesi

VMVTNLMEGGRNKCHQYWPDSD-SVYYGPFKVTLIDKQVlPDYTVRELQLILLGS-----DQP----PLMITQYHFTSWPDHGVPEYATSILqfHRRIKN
... . .| || ||  |||    .  ||  .|| . .    .. . .| . ..       .||     | ..  ..  ||| |||.     .   .|.  
lllckvgeegrpkcvgywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv..pqrlla

EYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRARS
. .  .|| .||||||..|... .|... ......   .|.  ..  ....|.  .||  . 
qvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqy

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 486-723 8e-32 105.0 In-house 45-279 (290) alignment
Range on Protein: 486-723
Range on HMM: 45-279/290.0
EVTHNIASQNK--DKNRSTQFLPPDNHRVVLK-GQQPNYINAVYVDSYKerKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT
 .  .|  .|    |||  .    |  ||.|| |.. .|. | ||.  |    ||... .. .|| ..|.|. . .|.||||||.  |.    | .|.| 
ylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype

EATEVI-FGEYSIKLLNEELYDLYTE-RTIEIKNKmKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMnktQRRSGntSIVVHCSDTVGRSAMFCAA
.. ||. |||...   .|.  |  .  .|. ...| . |  ||.  ..|  |  .       |.| .|  .   .. ||   .|||||  .||.  | | 
keGevltfGeitvlcseeddkdaniikktlsvrdk.dsGkehklkhlkikswpdksvalstlallrtlril...rkasG..pvvvhcsaGiGrtGtfvai

ATTInKCKTEG-VIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
 ... .. ..|  .|. .. .. |  . .|||   ||  . ||.
evgl.qilldGkeldlldlvralrnsrlnsvqvdiqylalveil

PTPc_DSPc_SM00012 362-451 9.9e-32 104.6 In-house 2-94 (105) alignment
Range on Protein: 362-451
Range on HMM: 2-94/105.0
ITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTK--GPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMFMVQTRA
...||.|.||||||||...|||.. | .|....  .  .|..|||||||||||||.|.|. ||| ||| . .||  |....|.||. |||| .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 491-723 1.4e-31 104.2 In-house 41-232 (392) alignment
Range on Protein: 491-723
Range on HMM: 41-232/392.0
IASQNKDKNRSTQFLPPDNHRVVL----KGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDeevcykywpteate
    |. |||  . || |. ||.|       . .|.|| |..|..  ||.| ...|  ... .||.|. . |||.|.|. . || |              
qkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..............

vifgeysikllneelydlytertieiknkmKGGSRHKVVQYQITGWePNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINK
                              || . . | |...| | |. .|  | . |. . .  |..  .    ...|||  |||...  .  . . .
..............................kgddartvaqfhftew.PdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvah

CKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
.|.  ..|||...   | ..|  ||| |||  |.  |
akktrmvdvfnfvtnirrkrpymvqtkeqyafiygav

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 260-451 3.3e-30 99.9 In-house 77-268 (301) alignment
Range on Protein: 260-451
Range on HMM: 77-268/301.0
YINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPD--SDSVYYGPFKVTLIDKQVL-PDYT-VRELQLILLGS
 | | .|.    . |.||||||. ||  ||| .. | . . |||... .|   .||..| |   |...  | ||... .|...  . .  |.|..     
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

DQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
. ..  .| | ...|.|.|||.  . . ..   .|.    .. |..||||||.||. .|.. ..  .. | .  |..   ....|..|   |||. 
kfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtns

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 461-716 4.1e-30 99.6 In-house 16-270 (301) alignment
Range on Protein: 461-716
Range on HMM: 16-270/301.0
QDPETGQTGYNKQFTVLEQVTQKPDEVTHNIASQNKDKNRSTQFlP--PDN-HRVVLKGQQpNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDI
.| .     ||  .  ..  | . |..|.  |  .|||.|  .  |  |.   .|. .|..   | | ....  . . ||.. .|. .|  .|| |.   
kdddktakfynttienvnvttidkdhitesyaylpkdkhryptv.PckPstavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqy

NVTAIVMLCQEKENDEEVCYKYWPTEATE-VIFGEYSIKLLNEE--LYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEeMNKT
.|  ||||.|. |. ||.| .| |.. .| .  | ..||. |.|  | .  ..||.|...  .  . . |. || . |  .|    |  .  ..| . | 
dvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme.lvkk

qrrSgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQY
   | .  ||||||. .|||  | ..    .. ...  |.. . ||  | ..  .|||..| 
...s.ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 227-450 5.2e-30 99.1 In-house 54-275 (305) alignment
Range on Protein: 227-450
Range on HMM: 54-275/305.0
KNKPLNRFRNVLVYDDNRIILKpLPShegcQNDYINASFIDGY-SSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSV
 ..  ||...| . | . . |.  ||      ||| | ..        |.|..|||. .|. .|| .. |.|   |||. . .| |. || |||| .   
iaitknryqdvpcqdqsavkld.kps....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

YYgPFKVTLIDKQVL---PDYTVRELQLILLG---SDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNeykpTKGPMLVHCSAGVGRTGTFMAIDM
    .|  .. ..|    |     |.|. ||    | .  . . . ..| ||| |||    . |..   |.     .| |..||||||.||||| .||. 
kl.elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaiey

GLQQ-AEKEGGIDIISIINRMRQQRMFMVQTR
 |.. ||.     .  ... .|.|| | .|. 
ilekiaenkpcppmpelvkalrdqrafsiqnd

0046846 (Phosphotyrosine protein) phosphatases II 516-728 2.3e-28 94.5 In-house 9-174 (176) alignment
Range on Protein: 516-728
Range on HMM: 9-174/176.0
GQQPNYINAVYVDSYKerkaFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIfgeysikllneelydlytertieiknk
.  ..|||| ......    .|.   |. .|. .|..|. . ..||.|.|..|.| .   |. ||| . .. |                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

mkggsrhkvvQYQITGWEPNGEVTChQAILMILEEMNKTQRRSgnTSIVVHCSDTVGRSAMFCAAAttinKCKTEGVIDVFQVLKSQRIQKP-GSVQTVE
          ||. ..|. .|  .  ...| .||.... ...     ..||||  .||.....||      ...|  ..|...|.  | |.| |.||| |
..........qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYKGIFEIVQIYLD
||. . | .. .|.
Qyrflyefellllk

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 222-451 1.1e-27 91.8 In-house 37-258 (288) alignment
Range on Protein: 222-451
Range on HMM: 37-258/288.0
ISVSQKNKPLNRFRNVLVYDDNRIILKplpshEGCqNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPD
|..  .|   .|..|.   |  |. |.     . . . ||.|  .       | | .| |.  |.  .|... ..  . |||...|.| |..|  .|.| 
idsfianptrdryenlprcditrvkls.....ddp.dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs

S--DSVYYGPFkVTLIDKQVlpDYTVRELQLILLG---SDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKptkgPMLVHCSAGVGRTGTFMA
   ... .| .  | . |.   .   . ... ||      . . .. . |.  |.|.||||   | |..  ..|.  |    |..||.|||||||||.. 
klGekarigrl.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtlil

IDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
| . |...  .  . | |.....|..|.  .||  
ilialeslrlddflgirsllaklreerfkaiqtem

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 467-723 2e-27 90.7 In-house 19-275 (439) alignment
Range on Protein: 467-723
Range on HMM: 19-275/439.0
QTGYNKQFTVLEQVtqKPD-EVTHNIAS--QNKDKNRSTQFLPPDNHRVVLK----GQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINV
|  ... |  .. .  .|| ..  ..|.   .. |||  .  . |  ||.|.      .  |||| |.. | . | .| .. |   |. .||... . ..
qeifkeifekinst..spdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekkt

TAIVMLCQEKEndeevCYKYWPTEAtEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRH-KVVQYQITGWePNGEVTCH-QAILMILEEMNKTQRR
. ||||..  |      |||||..| ||..|. ...   .     |. | . . |.   . .   |.|.. . | |. .| ..   .|  |  .| .. .
vtivmltnlve.....sykywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiaw.pdknvpaqashvldflrainsandk

SGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
     .|||||  |||.    |   .... |.|  .|.  ..|  | |.   ||.. ||  |.. |
eeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav

0049772 (Phosphotyrosine protein) phosphatases II 494-731 2e-27 92.1 In-house 45-284 (314) alignment
Range on Protein: 494-731
Range on HMM: 45-284/314.0
QNKDKNRSTQFLPPDnHRVVLKG---QQPNYINAVYVDSYkerKAFIIAESPMFSTVRNF----------WKMI--EDINVTAIVM--------------
 |.||||....|| | .||.|.|   .  .|||| |||..   ..||... |.  || .|          |.|.  .|.||  |||              
lnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCQEKENDeevcykywpteateV--------I-FgeysikllnEELYDL--YtertieiknkmkggsRHKVVQYQITGWEPnGEVTCHQAILM
       |..  .|                                    |||||   .                . ...|  . ..  |..   . .. 
aAlgKtpllildgng..............neptaadlellk.........eelydpelf...............erlgikylripvpD.gsaplledfde

ILEEMNKTqrrSGNTSIVVHCSDTVGRSAMFCAAATTINKCkteGViDVFQVLKSQRIQKP-----GSVQTVEQYKGIFEIVQIYLDSFM
.|| ...    . .. ..|||.. .||.. |..||  . ..   || .. ..|.  | . |     |.... |||  |.|... ||. ..
flefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflk

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 494-720 2.8e-27 90.4 In-house 7-234 (239) alignment
Range on Protein: 494-720
Range on HMM: 7-234/239.0
QNKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYK-ERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEvi
 || ||| .. .  |  ||||.      . .|||| |.  |    ||.| ..  .  .  .||.|. .     ||||    |  .. |..|||  ...  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..

FGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCK
. .  . | . |..  |  ||. . .  .    . | ||..| |  .|      |.| .  .. |     |    |.|||  |||.  |    . . ..|
ycnlrvtlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqak

TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
 .  .|.|. .|. | ..|  ||| |||  |.
kqktvdifnyvkairedrphmvqtseqyvfih

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 495-720 3e-27 90.3 In-house 7-233 (239) alignment
Range on Protein: 495-720
Range on HMM: 7-233/239.0
NKDKNRSTQFLPPDNHRVVLKG----QQPNYINAVYVDSYK-ERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEviF
|| ||| .. .  |  ||||.      . .|||| |.  |    ||.| ..  .  .  .||.|. .     ||||    |  .. |..|||  ...  .
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk..y

GEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKT
 .  . | . |..  |  ||. . .  .    . | ||..| |  .|      |.| .  .. |     |    |.|||  |||.  |    . . ..| 
cnlrvtlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakk

EGVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
.  .|.|. .|. | ..|  ||| |||  |.
qktvdifnyvkairedrphmvqtseqyvfih

subfamily_egg_pd Subfamily egg 203-449 3.3e-27 90.0 In-house 15-255 (307) alignment
Range on Protein: 203-449
Range on HMM: 15-255/307.0
EFMKQYALFHNDLDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKpLPSHeGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIV
|. ... . ..  |.  .| ..|. |.   | . |   |  |. |. |.      .|.| |  ..|      .| .| |. ||  ||||...||. . ||
elerrlevleesvdeislttaasdnnlekarskrvhckdssrvkle.lrrG.qylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyiv

MVTNLMEGgrNKCHQYWPD--SDSVYY--GPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFtSWPDHGvpeYATSILQFHRRIKNEYKptkg
|.|   |   ..|. |||   |||. .  | .... .. .  .|   |  .| |.|.|.  . .  .    .   .      | |.  |...|  |    
mltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss...dvysplrvlrklrnlsk....

PMLVHCSAGVGRTGTFMAIDMGLQQAEKEgGI---DIISIINRMRQQRMFMVQT
|..|..  || ...|..||.. | .  .   |    .   .  .|..| . |..
pvvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsves

0043147 (Phosphotyrosine protein) phosphatases II 520-720 4.4e-27 90.3 In-house 6-154 (172) alignment
Range on Protein: 520-720
Range on HMM: 6-154/172.0
NYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEkendeevcykywpteatevifgeysikllneelydlytertieikNKMKGG
.|||| |.| |   . ||.   |. .|.  ||.|. . ..|.||.|...                                              . . .
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydpel

SRHKVVQYQITGWEPNGEVtCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTInkckteG-ViDVFQVLKSQRIQKPGSVQTVEQYKG
  . ..||. ..|. .|     . .| .|| ... . .| .  ..||||  |||.....||   .        . .......  | ..||.||. .||. 
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrf

IF
. 
ly

0048076 (Phosphotyrosine protein) phosphatases II 318-450 4.9e-27 89.8 In-house 2-129 (145) alignment
Range on Protein: 318-450
Range on HMM: 2-129/145.0
YWPD--SDSVYYGPFKvTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEYKPTkGPMLVHCSAGVGRTGTFM
|||.   ...|.|..  | .| . | |. .. .  .    . .  ...||....|||||||. .  .|.| . |.. .|   ||.|||||||||||||..
ywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv

AIDMGLQqaekeGGIDIISIINRMRQQRMFMVQTR
|... |.      |... ......|.||...|.. 
aaylmll.....lgvsleealelvrsqrpgavpnp

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 272-447 8.5e-27 88.6 In-house 4-187 (199) alignment
Range on Protein: 272-447
Range on HMM: 4-187/199.0
AYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDS--VYYGPFKVTLIDKQVLPDYTVRELQLILLGSdQPPL--MITQYHF
  |||||| |. .|. |||...|.     |||| .           ||| ..|    || . ||     . ||||.  | |    .  ||    |..| |
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt.appstreishyqf

TSWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMFMV
||| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  ..
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgii

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 472-726 9.1e-27 88.8 In-house 20-276 (307) alignment
Range on Protein: 472-726
Range on HMM: 20-276/307.0
KQFTVLEQvtQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK--GQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEK
 .|.|| .  ..|. || .  | | |||| ..    |. |.|.|  |   .|| | |.    . | || |. |. .|. .|| |. . .| ...|||.  
defrvlak..ktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

ENDEEVCYKYWPTEA-TEVIFGEY--SIKLLNEELYDLYT-ERTIEIKN-KMK-GGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQrrsgnTSI
|  .  | .||| |   . .|||   .| . |     |   |  |.. . |.. ..    . ..| . |  .|      . . .|| ..  .       .
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.....npv

VVHCSDTVGRSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
|||||  ||||    | .   .|  . .   |. ....  | |.. ..||  ||  .  ..  |
vvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 273-447 9.9e-27 88.4 In-house 4-186 (198) alignment
Range on Protein: 273-447
Range on HMM: 4-186/198.0
YRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDS--VYYGPFKVTLIDKQVLPDYTVRELQLILLGSdQPPL--MITQYHFT
 |||||| |. .|| |||...|.     |||| .           ||| ..|    || . ||     . ||||.  | |    .  ||    |..| ||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt.appstreishyqft

SWPDHGVPEYATS--ILQFHRRIKNEYKPTK-GPMLVHCSAGVGRTGTFMAIDMGLQQAE--KEGGIDIISIINRMRQQRMFMV
|| ..  |. |    ..   | . . |.  |  |..|||| | | || |.|.|.|..  |  |   .|.. . .|.|| |  ..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgii

0049260 (Phosphotyrosine protein) phosphatases II 526-720 1.1e-26 88.8 In-house 1-143 (152) alignment
Range on Protein: 526-720
Range on HMM: 1-143/152.0
YVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWpteatevifgeysikllneelydlytertieiknkmkggsrhkvv
..| |.  ..||... |.  |. .||.|. . ..|.||||... |.... |..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

QYQITGWEPNGEVTCHQAILMILEEMNKTqRRSGNTSIVVHCSDTVGRSAMFCAAATTInkckteGVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
||. . |. .|  . .| .|..|. ..|  ... .  ..||||  |||.....||   .        ........  | ..||.|.. .|.. ..
qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_CG42327_pd Subfamily CG42327 224-392 6e-26 85.9 In-house 24-193 (319) alignment
Range on Protein: 224-392
Range on HMM: 24-193/319.0
VSQKNKPLNRFRNVLVYDDNRIILKPLPSHEgcQNDYINASFIDGYSSAY-RYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDS
|    |. .|. ||.   . |..|.  ....  .. |..||.. || .|   |||.| .. ..  ||||..|. .  ||| .|.| | | ..| .|.| .
vPvtskdksrvinvvPlPetrvvlqrigddd..kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk

DS----VYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQpPLMITQYHFtSWPDHGVPEYATSILQFHRRIKNE
..      || ..||| ...|   | .  | |  .  ..    .| | .  |.. .||   ....    .... 
etldntslyGdilvtlkgrevkdryaistlllkrvdkee.srelthywy.kwleaevPaeeaaliamllevrss

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 204-422 9.4e-26 85.2 In-house 21-234 (312) alignment
Range on Protein: 204-422
Range on HMM: 21-234/312.0
FMKQYALFHNDLDKHEMTISVsqKNKPLNRFRNVLVYDDNRIILKplpsheGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVM
. |.|    | .   | |  .  | | |||. |. ..|  |. |       | .| || | |.   .   |...||||. || . ||.|        |..
ltkeykavgnivsdsectafl..kfkdlnrypniqcwdrgrftla......gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiil

VTNLMEGGRNKCHQYWPDS--------DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPlMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykp
.. ..| | .|| .|  |           ||        |  .     | | |....  . |    . .| ..||||||.|.   . |..   .|..   
lcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalrllsavkkd...

tKGPMLVHCSAGVGRTGTFMAIDMGLQ
 | |.. |||||||||||.. |.  . 
.kkpviahcsagvgrtgtlaliesmia

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 219-322 3.3e-25 83.5 In-house 38-153 (350) alignment
Range on Protein: 219-322
Range on HMM: 38-153/350.0
EMTISVSQKNKPLNRFRNVLVYDDNRIILK--PLP----SHEGCQNDYINASFIDGY------SSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTN
.. .|   .    ||..|.| |. .|..||  . .     |    ||||||...          . ..|||||.|. .|. ||...| . | .||...|.
DvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

LMEGGRNKCHQYWPDS
..| ...||..||.. 
dvelnlekcyrYWqeg

0048179 (Phosphotyrosine protein) phosphatases II 323-450 5e-25 83.3 In-house 9-131 (144) alignment
Range on Protein: 323-450
Range on HMM: 9-131/144.0
DSVYYGPFKvTLIDKQVLPDYTVRELQLILLGSDQPPLMIT--QYHFTSWPDHGVPEYATSILQFHRRIKNEYKpTKGPMLVHCSAGVGRTGTFMAIDMG
...|.|..  |..| . | .. .. .  .  . ... |  .  ||....|||||||.... .|.| . |.. ..  .||.|||||||||||||..|... 
pglylgslp.taldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylm

LqqaekEGGIDIISIINRMRQQRMFMVQTR
.     . |... ......|..|...|...
k.....klglsleealalvrsrrpgavpnp

subfamily_ptpA1_pd Subfamily ptpA1 473-686 5e-25 83.1 In-house 26-255 (418) alignment
Range on Protein: 473-686
Range on HMM: 26-255/418.0
QFTVLEQVTqKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKeRKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQE
.| .||.    | | .     .|  ||| |. || .  || ||  |     .|||| |.|     | || .. |.  |. .||.|. .  .  |||| .|
efrlleesv.gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsre

KENDEEVCYKYWPTEA----------TEVIFGEYSIKLLnEELYDLYTE-RTIEIKNKMKGGSRhKVVQYQITGWePNGEVTCH-QAILMILEEMNKTQR
 ||    | .||| .            . .|| ||..|. | . |   |  | .|.  ..| .|  . |||  || |. ..  | | .  .|  . . | 
sencrikcdrywpeqiggeqfsiygngnevfgtysvelv.eviqdpereiitrnirltfegetr.ditqyqyegw.pdhnipdhtqpfrqllhsitnrqn

----R-SGNTSIVVHCSDTVGRSAMFCAAATTINK
        |  |.||||  |||.  ||.|   ..|
qiipssdrnvpiivhcsagvgrtgtfctavimmkk

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 460-727 5.7e-24 79.4 In-house 14-287 (305) alignment
Range on Protein: 460-727
Range on HMM: 14-287/305.0
EQDPETGQTGYNKQFTVLEQVTQkPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQP-NYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDIN
..  | | .|  ..|. .... .  . .     .|...|||  .    || || |.|  | .|| | || .  . | || ...|.  |  .|| |  . .
krtlekgpaglraefvamkrfnd.fekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdk

VTAIVMLCQEKENDEEVCYKYWPTEATEVI-FGEY----SIKLLNEELYDLYTERTIEIKNK-----MKGGSRHKVVQYQITGWEPNGEVTCHQAILMIL
| || |||. .|   . |..|....  .|. | |     |.|.   . ... ..   ....        |.. .|| .|    |   |  .  .||| .|
veaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailell

EemnKTqrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVID-VFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
|   |.  |.    ||||||  .||.         ...  .  .|.   ..|.  | |.  |.|| .||  . ...  |.
e...ka..rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 232-449 1.8e-23 78.1 In-house 23-244 (290) alignment
Range on Protein: 232-449
Range on HMM: 23-244/290.0
NRFRNVLVyDDNRIILKPLPSHegCQNDYINASFIDgYSSAYRYIATQGPMAN-------TLVDFWRLIWQEKPHVIVMVTNLMEGGRN----KCHQYWP
.| .. ||  ..|..||   ..   ..||| |...  ...  | |.|| | ..       |. .|| .. ||| . .||. . .|  .|     | .| |
qRlevpLv.eatrvvLkgygkr..fnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

DSD--SVYYGPFKVTLIDKQVLPDYTVRELQLILlgSDQPPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEykptKGPMLVHCSAGVGRTGTFMAID
.|   .. .. ..|   .|    |  .||| .     |. .. .| . . .| .  |.|   ..|.  . .|..    | |..|||  |. |  .. ||.
esvgeelkfkgltvkCkskekeddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaii

MGLQQAE-KEGGIDIISIINRMRQQRMFMVQT
.| |    ..| . . .... .|.||  ....
lgyQkiaetsgsvkledvlkalrkqralaits

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 280-451 2.3e-23 77.1 In-house 98-275 (302) alignment
Range on Protein: 280-451
Range on HMM: 98-275/302.0
GPMANTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDS--DSVYYGPFKVTLID-KQVLPDYTVRE-LQLILL------GSDQPPLMITQYHFTS
 |  .||  .| || | .  ..| .....|.. .|| .|. |   . . .| . |. .. |. | ..| .. ..|  .        .. .  .   .|..
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPEYATSILQFHRRIkNEYKptkGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
||||| |. | . |.  .   . ||     .|||||||||||||..||  |.|   |.   |..||.  .|| |   ||.  
wpdhGapkeaytaldilkfc.esyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeq

0051082 (Phosphotyrosine protein) phosphatases II 519-718 3.5e-23 77.3 In-house 3-144 (151) alignment
Range on Protein: 519-718
Range on HMM: 3-144/151.0
PNYINAVYVDSYkerkaFIIAESPmfstVRNFWKMIEDINVTAIVMLCQEKENDeeVCYKYWPTEAtevifgeysikllneelydlytertieiknkmkg
..|||. ||...     ...   |       |...... ....||.|..|.|..   |..|.| .                                   
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

gsrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKtqrrSGNTSIVVHCSDTVGRSAMFCAAATTINKcktegvIDVFQVLKSQRIQKPGSVQTVEQYKG
   ..|....|..| . |  .. .|.| .||....     .|  ..||||  .||.....|.   . .      ......|.  |.. ||.||. .|.  
...ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf





subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 492-723 4.2e-23 76.4 In-house 34-265 (281) alignment
Range on Protein: 492-723
Range on HMM: 34-265/281.0
ASQNKDKNRSTQFLPPDNHRVVLKGQQPN-----YINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATE
   |. ||| ..    |  || || . ||     || | |. |   .. .|... |   |  .||.|| . | ||||||||  | . | | .|.| .|  
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

V-IFGEYSIKLLNEELYDLYTerTIEIKNKMKGGSRhKVVQYQITGWePNGEVTCHQAIlmILEEMNKTQRRSgnTSIVVHCSDTVGRSAMFCAAATTIN
.  | ..|..  .  .       |  ..   .| .|  . ..    | |. .|     .  .|. . | . ||  |  |.|||  ||||  . |   ...
clqfdklsvsyedstvnkslv..ttrlnlsyegetr.lithwlwkew.pdwqvpessev..mlkilrkirars..tppvihcsagvgrsgtlmaveialq

KCKTEG-VIDVFQVLKSQRIQ-KPGSVQTVEQYKGIFEIV
  ..   . |. |..   |.  .  ||||..||  |....
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 494-727 3e-22 74.0 In-house 42-271 (288) alignment
Range on Protein: 494-727
Range on HMM: 42-271/288.0
QNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVI-FGEY
.|  ..| ..    |  || |.     ||.|  | | | .. .| |..|. .|. ..|||. . .|  |||||.  |   |   .|.|..  | . .| .
anptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

sIKLLNEELYDLYTERTIEIKNKMKGGSRHK-VVQYQITGWEPNGEVTCHQAILMILEEMnktqrRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEG
  .   ..  |.    .. . .  | |  .. | .  .  |. .|    ... | .|| .     .| .  ||||.|  |||.. .      ..  . . 
.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrldd

VIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
 . . ..|.. | ..  ..||  ||  .. .|  .|
flgirsllaklreerfkaiqtemqylyvhrcvleel

0044763 (Phosphotyrosine protein) phosphatases II 518-725 3.1e-22 74.5 In-house 17-169 (178) alignment
Range on Protein: 518-725
Range on HMM: 17-169/178.0
QPNYINAVYVDSYkerkaFIIAESPMfstvRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATevifgeysikllneelydlytertieiknkmk
   ||||.... .     ....  |.     ...... . ..|.||.|..|.|.  . |..|||.||                                 
rsdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................

ggsrhkvVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrSGNTSIVVHCSDTVGRSAMFCAAATTINKckteGViDVFQVLKSQRIQKPgSVQTVEQYK
       .||. .... .|. .  . .| ..| ... .  . .  ..||||  ||||....||   .      |. .......  | ..|  |.. .|..
.......iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlr

GIFEIVQI
 . |. ..
qLyefelr

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 499-721 7.9e-22 72.7 In-house 23-253 (290) alignment
Range on Protein: 499-721
Range on HMM: 23-253/290.0
NRSTQFLPPdNHRVVLKGQQ----PNYINAVYVdSYKERKAFIIAESPMF-------STVRNFWKMIEDINVTAIVMLCQEKENDEE----VCYKYWPTE
.| .  |   . ||||||       .|| | .| .. .  ..|. .||         ||. .|| |. . .|. .||||. .|....     | || |..
qRlevpLve.atrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

AT-EVIFGEYSIKLLNEELYDLYTERTIEIKnkMKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTqrrsgNTSIVVHCSDTVGRSAMFCAAAT
.  |. |.  ..|  . |  |   .|....|    ..  ..|  ... ||..      .. .| ... ...      .| ..||| | . |||.. |   
vgeelkfkgltvkCkskekeddvetRelvvk..fddeeeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiil

TINKCK-TEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
   |   |.| . . .|||. | |.   ... ...  .  
gyQkiaetsgsvkledvlkalrkqralaitsalelafvda

PTPc_DSPc_SM00012 623-721 9.5e-22 72.6 In-house 1-101 (105) alignment
Range on Protein: 623-721
Range on HMM: 1-101/105.0
KVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSG-NTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
.| .|..|||   |  .  ..|| .|....| .. |. ....|||||. |||...|.|... ......| . .|.||..|. | |.||.||| |||  . 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

E
.
r

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 484-723 6.7e-21 69.5 In-house 24-266 (285) alignment
Range on Protein: 484-723
Range on HMM: 24-266/285.0
PDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVD-SYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT
| ..|.     | | || ..    .. ||||| .. .|| | ..    |.. ..| .. |.  |. .||.|| . ... ..|||   |   | |  |.| 
ppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

EATEVI-FGEYSIKLL--NEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWEPNgEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCA
.  ||. ||.| | |   .||        .. . |     |    ...    | |. ...  .|  ||       .    .. |.||||  |||.| |  
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpd.qlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvg

AATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
   .  .   .  |.......  |  .  .||.  |.  .. ..
idyatirimenpniemldivremramrfqavqshmqflflyvvl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 492-726 2.9e-20 67.1 In-house 52-288 (305) alignment
Range on Protein: 492-726
Range on HMM: 52-288/305.0
ASQNKDKNRSTQFLPPDNHRVVLKGQQP-NYINAVYVDSY-KERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIF
|  .. ||| ..    |.  | |.  .| .|| | ||       | || |. |.  |. .|| |. . .|  |||||.  |     | .|||.   |   
adiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

GEYSIK---LLNEELYDLYTERTIEIKNK-MKGGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMnktqrRSGNTSIVVHCSDTVGRSAMFCAAATTIN
    |    .      .  .|  | . |  . |. .  | . | | |   |   |. . | .|  .     |  .  ||||||  .||.    |    ..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai.....rgskvpivvhcsagigrtgtivaieyile

KCKTE-GVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
|   .  .  . ...|. | |.  |.|.  ||  |  ..  |
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny

subfamily_egg_pd Subfamily egg 469-727 8.3e-20 65.7 In-house 15-270 (307) alignment
Range on Protein: 469-727
Range on HMM: 15-270/307.0
GYNKQFTVLEQVTQKpDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKGQQ----PNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVM
...... |||.....   .|. ... |..| || .    |  || |. ..     ..| | .|.       ||.|..|.  || .||.|.   .|  |||
elerrlevleesvde.islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivm

LCQEKENdeEVCYKYWPTEATE-VIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRH-KVVQYQITGWEPNGEVTCHQAILmileemNKTqrRSGNTS
|   ||.  | |  |||   .. ...   |... | ....         | |. || .  . ...    ..  ..|     .|       |   |   . 
ltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvl......rkl..rnlskp

IVVHCSDTVGRSAMFCAAATTINKCKtEGVIDVFQVLKS---QRIQKPGSVQTVEQYKGIFEIVQIYL
.||.. . | ..| . |. ... .    | |  . ||..    | ... ||..| .|  .. .| ...
vvvqdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 285-449 5.1e-19 63.3 In-house 40-206 (255) alignment
Range on Protein: 285-449
Range on HMM: 40-206/255.0
TLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLIL-LGSDQPPLMITQYHFTSWPDHGVPEYATSIL
|.  |.. | | |..|.||.... | |..||..|.|          .|...  .   |  .| |.... ||  .    .. |... |...  || |  ||
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

QFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMFMVQT
.  . ...  |    ...||||.|.||. .|. ...  |      .  . ...| .|... .|..|   ..|
nilkvvrds.k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraiht

subfamily_CG42327_pd Subfamily CG42327 474-653 8.3e-19 62.4 In-house 11-192 (319) alignment
Range on Protein: 474-653
Range on HMM: 11-192/319.0
FTVLEQVTQKPDevthNIASQNKDKNRSTQFLPPDNHRVVLKGQ----QPNYINAVYVDSYKERKA-FIIAESPMFSTVRNFWKMIEDINVTAIVMLCQE
|  | |.  . |    ..    |||.|  . .|  . ||||. .    . .|..| ||  |.. .. .| |. .. ..  .||... . .   || |.. 
frdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdl

KENDEEVCYKYWPTEAT---EVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRhKVVQYQItGWEPNGEVTCHQAILMILEEMNK
 |.  .|| .|.||..|   .  .|.. . | . |  | |   |. .|.  |  || ..  |    |   .  . ..|.. .| |...
selGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesr.elthywy.kwleaevPaeeaaliamllevrs

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 540-717 1.7e-18 61.1 In-house 97-278 (302) alignment
Range on Protein: 540-717
Range on HMM: 97-278/302.0
ESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEV-IFGEYSIKLL--NEELYDLY-----TERTIEIKNKMKGGSRHKVVQ-YQIT
  |  ||.  .| .||. ||. .| ||. .|..|. | .|. ..  ..  ||.|..| .  ...| ..      .  |.||||. |    .| |.  . .
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

GWEPNGEVTCHQAILMILEEMNktqrrSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYK
.|   |     .. | ||   .     |  ....||||  |||.  . |    |. |... | |. ....  |  . |.||. .|  
awpdhGapkeaytaldilkfce.....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 494-734 8.3e-18 59.1 In-house 42-283 (312) alignment
Range on Protein: 494-734
Range on HMM: 42-283/312.0
QNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATE------V
. || ||  .    |  |  | |..  || | .|      . |.....|. .|. .||..   .  |.|..||   |.  | | ||     .        
kfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

IFGEYSIKL-LNEELYDLYTERTIEIKNKMKgGSRHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRrsgntSIVVHCSDTVGRSAMFCAAA---TT
.. ||  .. .     |  | | . .  |   |   |. .|| . |   |     .. | .|  ..| ..      .. |||  |||.  ..      ..
vyteycteieiggkskdkithrvlkvvvkat.gqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaa

INKCKTEGVIDVFQVLKSQRIQkpgSVQTVEQYKGIFEIVQIYLDSFMLYS
. . . . | |.| .|. .| .   ||... ||   . .|  .| |  || 
lrhprkqnvkdsfvllrkdrar...svrvfpqyvyalrcvleflyskglyk

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 531-721 1.5e-17 58.4 In-house 2-198 (199) alignment
Range on Protein: 531-721
Range on HMM: 2-198/199.0
KERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT-EATEVIFGEYSIKLLNEELYDLYTERTI-EIKNKMKGGSRHKVVQYQ
| .. .| .. |.  |. .||.|. .     |||. ... | |     |||| |..   .|  |.          ||  ..   .|     |  .. .||
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

ITGWEPN--GEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
.| |  .   .|.    ...   |. |   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . ....|. |..
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 491-727 1.7e-17 57.8 In-house 47-285 (302) alignment
Range on Protein: 491-727
Range on HMM: 47-285/302.0
IASQNKDKNRSTQFLPPDNHRVVLKGQQPNYINAVYVDSYKERKAFIIAESPMFSTV---RNFWKMIEDINVTAIVMLCQEKENDEeVCYKYWPTEATEv
.  .| .||.|...  .|...| |.... .|.||  |.  . ..  |.|  |  ...    .||.|. . ... .|.| .|.| ..    ...|... . 
afkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd.

iFGEYSIKLLNEELYDLYT----ERTIEIKNKMKGGSRHKVVqYQITGWEPNGEVTCHQAILMILEEMnKTQRRSGNTSIVVHCSDTVGRSAMFCAAATT
 . ||    .|    .       . .||.  .    |    | | .| |...   .   ..    ...  ..  ... ..|.     .|| ..| ..|..
.ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanv.yvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlava

INKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIYL
..| ...    . ...|| | |.| .|....||  .. .. .|.
veklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 482-706 2e-17 58.1 In-house 16-200 (255) alignment
Range on Protein: 482-706
Range on HMM: 16-200/255.0
QKPDEVTHNIASQNKDKNRSTQFLppdnhrvvlkgqqpnyinavyvdsykerkafiiaespmfsTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWP
.  |. |.... ... |..... |                                        || .|...|   . . .||||  .|.. | | .|.|
idedvctehvkPekdkkrknlysl........................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfp

TEATE-VIFGEYSIKLLNeELYDLyTERTIEIKNKMK-GGSRHKVVQYQITGWEPNGEVTCHQAILMILeemnKTQRRSgnTSIVVHCSDTVGRSAMFCA
.|  |  .. . ..   .    |    ||.||  ..      |.|  |. .||  .      . || ||    |  | |   |.|||||  .|||| |  
lekdeklkladvnvtttk.ssadv.vlrtleitstlgekkkthtvkhysykGWieknaPelareilnil....kvvrds..ksvvvhCstGiGrsaafvl

AATTIN-------KCKTeGVIDVFQVLKSQRIQK
|            . .| . .|  ..|.  | ..
aelvyqkmirsldttet.veldylslleelrskr

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 533-721 2e-17 58.0 In-house 3-197 (198) alignment
Range on Protein: 533-721
Range on HMM: 3-197/198.0
RKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPT-EATEVIFGEYSIKLLNEELYDLYTERTI-EIKNKMKGGSRHKVVQYQIT
.. .| .. |.  |. .||.|. .     |||. ... | |     |||| |..   .|  |.          ||  ..   .|     |  .. .||.|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

GWEPN--GEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTIN---KCKTeGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFE
 |  .   .|.    ...   |. |   .  .. ..|||||  | . .| |    .    . ||  |.|.|.| |  |  . | . ....|. |..
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheeskt.svvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 202-449 2.6e-17 57.2 In-house 30-270 (302) alignment
Range on Protein: 202-449
Range on HMM: 30-270/302.0
EEFmKQYALFHNDLDKhemtISVSQKNKPLNRFRNVLVYDDNRIILkplpshEGCQNDYINASFIDGYSSAYRYIATQGPMANTL---VDFWRLIWQEKP
.|| |. . .  ||.|     .. .||   |.  .| ..|.|...|      |.....|.||| ..  .  .  | .| |  ..     .|||...||| 
kef.kkidtmkvdlek....Ckafkknlkknqsedvpildsnlvkl......eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

HVIVMVTNLMEGGRnKCHQYWP--DSDSVYYGPFKVTLidKQVLP--DYTvRELQLILLGSDQ-PPLMITQYHFTSWPDHGVPEYATSILQFHRRIKNEY
  .|..    |  .   ....|    | ..|| . |    ..|    . .  .. . .|  .    .... |..| |... ||.  ... .    . .. 
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNn..rkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakk

KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQT
 ... ....    |.|| |.|..  . ... .|.    |  |.. .|.||  .|..
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravds

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 494-633 4.6e-17 56.8 In-house 32-175 (297) alignment
Range on Protein: 494-633
Range on HMM: 32-175/297.0
QNKDKNRSTQFLPPDNHRVVLKGQQP--NYINAVYVDSYKERK--AFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVI-
    ||| .. |  |. || |..  .  .|||| ||   .| .   .|.|. |. .|| .||... . .| .|||... .|.  . |. |||    |   
sslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlk

FGEYSIKLLNEELYDLYTERTIEIKNKMKgGSRHKVVQYQITGWE
 |.. .. | .   .  .    |..   .   . .|   |  .| 
agdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswp

subfamily_hpo-7_pd Subfamily hpo-7 531-711 5.3e-17 56.6 In-house 42-211 (263) alignment
Range on Protein: 531-711
Range on HMM: 42-211/263.0
KerkafiiaespMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATE-VIFGEYSIKLLNEELyDLyTERTIEIKNKMK-GGSRHKVVQYQ
            .  |. .|...|.  . . .||||  .|.. | | .|.|.|  |  .. . ..   .    |.   .|.|. . ..     |.| .|.
l...........lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dv.llktlellstlgeKkkthtvkhys

ITGWEPNGEVTCHQAILMILeemnKTQRRSgnTSIVVHCSDTVGRSAMFCAAATTIN-------KCKTeGVIDVFQVLKSQRIQKPGSVQ
 .||  . ...  . || ||    |  | |   |.|||||  .|||| |  | .          . .| . .|  ..|.  | .......
ykgWiekndpelareilnil....kvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttst.veldylsLleelrssrkraih

subfamily_hpo-7_pd Subfamily hpo-7 284-449 6.6e-17 56.3 In-house 45-212 (263) alignment
Range on Protein: 284-449
Range on HMM: 45-212/263.0
NTLVDFWRLIWQEKPHVIVMVTNLMEGGRNKCHQYWPDSDSVYYGPFKVTLIDKQVLPDYTVRELQLIL-LGSDQPPLMITQYHFTSWPDHGVPEYATSI
.|.  |.. | | |..|.||...  | |..|| .|.|          .|..   .|  |  .. |.|.  ||  .    ...| .. |...  || | .|
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LQFHRRIKNEyKptkgPMLVHCSAGVGRTGTFMAIDMGLQ------QAEKEGGIDIISIINRMRQQRMFMVQT
|.  .  .|  |    .. ||||.|.||.  |  ...  |      .  . ...| .|... .|..|   ..|
lnilkvarns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 466-590 3.1e-16 53.8 In-house 25-150 (310) alignment
Range on Protein: 466-590
Range on HMM: 25-150/310.0
GQTGYNKQFTVLEqvTQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK---GQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAI
|  |  ||.  |.  ...   .|..   ..  ||| .. .  |. || ||    .  .|| | || .   |..|| .. |.  |. .||.|| .    .|
gieglvkqyrkld..akqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesi

VMLCQEKENDEEVCYKYWPTEATEVIFG
..||.  |.    |  |||.      .|
lllckvgeegrpkcvgywpslgvtetyg

I-set Immunoglobulin I-set domain 77-162 4.1e-16 50.5 Pfam-A 2-90 (90) alignment
Range on Protein: 77-162
Range on HMM: 2-90/90.0
FIEEFPNNLTAEVGQEVHFKVKFKGTPTPSFNWYHNGEPVTDDYAHEIKGDG---SLLLVSVEKIHKGVYGFVANNDAGTVSQQVVLTV
 ... ........|..| .... .|.|.||..|...|.... .  .... ..   .| . .||.  .| |  .|.| ||...... |.|
kftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 621-723 5.4e-15 49.6 In-house 88-190 (440) alignment
Range on Protein: 621-723
Range on HMM: 88-190/440.0
RHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIF
 . . ||.  ||  .|       .| .....|..| ..||  ..||||  .||...  |  . . ..|    ||.| ...| | ..|  ||| |||  ..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

EIV
| |
eav

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 221-374 7e-15 49.3 In-house 89-234 (244) alignment
Range on Protein: 221-374
Range on HMM: 89-234/244.0
TISVSQKNKPLNRFRNVLVYDDNRIILkplpSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEkpHVIVMVTNlmeGGRNKCHQYWP
  ... .|   ||    | .| ||. |    |.    | ||||||.     .  || || |.|.| .|||... .   || |.|     |  ..  .|||
kdafnpnnswknregaglpfdfnrvpl....skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmler..hvnvlvvl...gsveeedeywp

DSDSV--YYGPFKVTLIDKQVLPDYTVRELQLIlLGSDQPPLMITQYHFTSWPDHG
||. .  |     ||| |.. . .    .|..     ..    .| .  . ||  |
dseplewyeeditvtltdrdefknikasnleie.sdmneshqaltmfqisnwpsdg

0048076 (Phosphotyrosine protein) phosphatases II 600-726 2.7e-14 48.5 In-house 24-142 (145) alignment
Range on Protein: 600-726
Range on HMM: 24-142/145.0
ELYDLYTERTIEIKNKMKGGSrHKVVQYQITGWEPNGEVTCHQAILMILEEMNKTQRRsgNTSIVVHCSDTVGRSAMFCAAATTINkcktEGvIDVFQVL
.| ||   . . . .  .. . ....||. ..|. .|. . .. .| .|| ... ...  .  ..||||  |||.....||   .     .| ......|
llkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleeal

KSQRIQKPGSVQTVEQYKGIFEIVQIY
.  | | ||.|....|.. ..| ....
elvrsqrpgavpnpgqlrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 551-719 4.1e-14 48.0 In-house 22-137 (144) alignment
Range on Protein: 551-719
Range on HMM: 22-137/144.0
WKMIEDINVTAIVMLCQEKENDEEVCYkywpteatevifgeysikllneelydlytertieiknkmkggsrhkVVQYQITGWEPNGEVTCHQAILMILEE
.... . ..|... |. | |.... ..                                              ..||. ..|. .|  .  . .| .|| 
lellkklgittvinlteeyepeflere..............................................giqylhlpwpDhgvpdllellleflef

MNKTQRrsGNTSIVVHCSDTVGRSAMFCAAATTInkckTEGvIDVFQVLKSQRIQKPGSVQTVEQYKGI
... ..   .  ..||||  |||.....||   .    ..| ......|.  | . ||.|.. .|.. .
ieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfL

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 219-322 4.2e-14 46.6 In-house 41-156 (349) alignment
Range on Protein: 219-322
Range on HMM: 41-156/349.0
EMTISVSQKNKplNRFRNVLVYDDNRIILKPLP------------SHEGCQNDYINASFID--GYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMV
...  |    |  ||....| |.  |..||  .            |. |  .||||| ..    .|   .||||| |.  |. ||...|  .. .... .
ilseGvelfak..nrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL

TNLMEGGRNKCHQYWPDS
..  | . .||..|| . 
nddkelslekcdiywqel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 485-585 2.3e-13 44.6 In-house 38-155 (350) alignment
Range on Protein: 485-585
Range on HMM: 38-155/350.0
D-EVTHNIasQNKDKNRSTQFLPPDNHRVVLK-GQ-----------QPNYINAVYVDSY----KERKAF--IIAESPMFSTVRNFWKMIEDINVTAIVML
| .... .  .   ||| .. || .  || || .              .|||| |.       .    |  | . .|. ||| .|.|.|   .|. |..|
DvilseGv..elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

CQEKENDEEVCYKYWPTEAT
 .. |.. | ||.||.  . 
tsdvelnlekcyrYWqegsy

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 184-280 6.8e-13 42.6 In-house 5-95 (95) alignment
Range on Protein: 184-280
Range on HMM: 5-95/95.0
IPVGKFGEFVADGHANNDEEFMKQYALFHNDlDKHEMTISVSQKNKPLNRFRNVLVYDDNRIILKplpshEGCQNDYINASFIDGYSSAYRYIATQG
| |  |   | . |.| |.|| ...            |.  |. | | ||| |.. ||  |..|         . ||||| |.|||.    |||.||
ihvsvfhshvlemhsnsdqefdnefksismt.sgapytvgsseanipknrflnifpydatrvvlt.....tkrdsdyinacfvdgyarkncyiaaqg

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 482-639 8.3e-13 42.5 In-house 83-237 (244) alignment
Range on Protein: 482-639
Range on HMM: 83-237/244.0
QKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVL-KGQQPN-YINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEevcykY
  |  .   .  .|  |||    || |  || | ||   | |||| .|        .|... |.  |  .||||. .  |  .|.|   .|.||     |
pdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....y

WPT-EATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGgSRHKVVQYQITGWEPNGEVT
||  |  |    . .. | . . .       .||.  |.  |   .  .||. |  .|   
wpdseplewyeeditvtltdrdefknikasnleiesdmne.shqaltmfqisnwpsdgttp

subfamily_CG42327_pd Subfamily CG42327 394-450 2.5e-12 41.1 In-house 244-301 (319) alignment
Range on Protein: 394-450
Range on HMM: 244-301/319.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKE-GGIDIISIINRMRQQRMFMVQTR
.  .||. |||| ||||||. .| |. ... |.    .||  ..  .|..|   |.|.
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 359-451 8.8e-12 39.4 In-house 214-331 (350) alignment
Range on Protein: 359-451
Range on HMM: 214-331/350.0
PLMITQYHFTSWPDHGVPEYATSILQFHR--------RI-KNEYKPT-KGPMLVHCSAGVGRTGTFMAIDMGLQQA-------EK-------EGGIDII-
|... | ..  |.| ..     ||||            . .. ..     |.|||||||||||||....|. |..        ..           |.| 
PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlis

SIINRMRQQRMFMVQTRA
 |.|..|.||. |||.  
iivnelrkqrismvqnld

subfamily_eak_pd Subfamily eak 501-649 1.2e-11 38.6 In-house 57-205 (332) alignment
Range on Protein: 501-649
Range on HMM: 57-205/332.0
STQFLPPDNHRVVLKGQQPN---YINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEA-TEVIFGEYSIKL
  . .| | . | |   | |   ||||  ..  .  . .|..  .  . |  ||.|. . .  |||.| .. |.. |   ||.| ..  |. || . .. 
vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver

LNEELYDLYTERTIEIKnkmKGGSRHKVVQYQITGWEPNgEVTCHQAILMILE
 .    . .  | .|..   ||   |.|  |.. ||    ..   .  | . .
kefvkrniletrllels...kGnethrvlhykvfGwtet.tlpkyedflalrk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 267-349 1.7e-11 38.1 In-house 230-310 (440) alignment
Range on Protein: 267-349
Range on HMM: 230-310/440.0
DGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEggrNKCHQYWP-DSDSVYYGPFKVTLIDKQVLPDYTVRELQ
.|||    .|||| |.  |..|||||. . .   |.|. .| .   . |  ||| .. || .||| |     . .    || |.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtle

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 204-450 4e-11 37.1 In-house 28-265 (303) alignment
Range on Protein: 204-450
Range on HMM: 28-265/303.0
FMKQYALFHNDLDKHEMtisVsqKNKPLNRFRNVLVYDDNRIILkplpshegCQNDYINASFIDgYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVM
| |  . .  .. |...   |  ||   ||| .|.. |  .. |        ..  || ||...   |  . | || |.. |  |||..| ..| .....
fekvvsylppsvsknqf...v..knmdknrfvdvicldhskvkl........sdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvll

VTNLMEGGRNKCHQYWPDS-DSVYYGPFKVTLIDKQVLPDYTVRELQLILLGSDQPPLMITQYHFTSWPDHGVPE-----YATSILQFHRRIKnEYKPTK
.    |  .   .  .|   | . .    . . . . .       |... .   .   ..  .|. .||   .|      .   | |    ..  | ...
lltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlr.kysdst

GPMLVHCsAGVGRTGTFMAIDMG-LQQAEKEGGIDIISIINRMRQQRMFMVQTR
 .. .   .|.||.|||  ..   |   ...  .|..  .. .|. |.  ||  
ptvymsl.sgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnl

subfamily_eak_pd Subfamily eak 213-387 5.6e-11 36.4 In-house 33-205 (332) alignment
Range on Protein: 213-387
Range on HMM: 33-205/332.0
NDLDKHE--MTISVSQKNKPLNRfrNVLVYDDNRIILKPLPSHEGCQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVTNLMEG
.|||...  ..||.... . .||  ||.    .   |  | |    .. ||||| ..      .|| |  .  . .  ||... ..|   ||.. . .| 
adlddyqrllsisetarleavnr..nvvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvel

GRNKCHQYWPDSD--SVYYGPFKVTLIDKQVLPDYTVRELqliLLGSDQPPLMITQYHFTSWPDHGVPEYAtSILQFHR
. .|  .|.||     . .| ..|.  .      . .| |    |        .  |..  | .  .| |    | ...
kleksdkyfpdktreelkfGildverkefvkrniletrll...elskGnethrvlhykvfGwtettlpkye.dflalrk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 496-602 1.3e-10 35.1 In-house 85-171 (349) alignment
Range on Protein: 496-602
Range on HMM: 85-171/349.0
KdknrstqflppdnhrvvlKGQQPNYINAVYVD--SYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWpteaTEVIFGEYS
.                   |.  .|||| |.    ..  | .|    |. ||| .|.|.|   .|  .. | ..||.. | |..||     |  . .. 
d..................sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw....qelsysnit

IKLLNEELY
.|| |  ||
vklqnssly

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 478-722 1.7e-10 35.0 In-house 29-274 (303) alignment
Range on Protein: 478-722
Range on HMM: 29-274/303.0
EQV-TQKPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLKgqQPNYINAVYVDSYKERKAfIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEEVC
|.| .  | .|..|   .| |||| .. .  |  .| |   .  || | |..   ..|| |... |.  |  .||.|| . .|  ...|  . | |.   
ekvvsylppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklgg

YKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRHKVVQYQITGWePNGEVTCH---QAILMILeEMNKTQRR-SGNTSIVVHCSDTVG
   .| .   . | | ||.. .    .|    .. .    .|  .  .  ..   | | ... ..   . .  |  ...   |. | .|  |      .|
dsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykaw.phnsipsdgspkfvkqiw.qlqsvlrkysdstptvymslsgcg

RSAMFCAAATTINKC-KTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEI
|.  |.   |.     . .  .|. ..|.  |  .  .|| . |.  .. .
ragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 219-304 1.9e-10 34.8 In-house 28-116 (347) alignment
Range on Protein: 219-304
Range on HMM: 28-116/347.0
EMTISVSQKNKPLNRFRNVLVYDDNRIILKPLPSHEGCQN---DYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMV
..| .  .|.   || ..| . |. |..| |  |. .  .    ||||| |    .   || || |. .|. |||...   |   .| .
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 227-314 3e-10 34.1 In-house 33-117 (332) alignment
Range on Protein: 227-314
Range on HMM: 33-117/332.0
KNKPLNRFRNVLVYDDNRIILKPlpshEGCQNDYINASFIDGYSSAYRYIATQGPMAN-TLVDFWRLIWQEKPHVIVMVTNLMEGGRNK
.|  .||   . ..| .|. | |    .  ..|. |||..||||    || .| |. . |   |||.. . || .|... .. |  . |
nnmdmnriphlycfdhsrvelap....qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 240-338 3.3e-10 34.4 In-house 5-90 (130) alignment
Range on Protein: 240-338
Range on HMM: 5-90/130.0
YDDNRIIlkplpshegcQNDYINASFIDGYSSAYRYIATQGPMANTLVDFWRLIWQEKPHVIVMVtnlmeGGRNKCHQYWPDSDSVY--YGPFKVTLIDK
.. .|.           .|.||||||.     .  |. || |.|.| .|||... .    |.|..     |  ..  .|||||. .        ||| |.
fevsrlq..........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl.....gsveeedeywpdsePlewyeediivtltdr

Q
.
d

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 483-573 4.5e-10 33.6 In-house 25-123 (347) alignment
Range on Protein: 483-573
Range on HMM: 25-123/347.0
KPDEVTHNIASQNKDKNRSTQFLPPDNHRVVLK---------GQQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCqEKENDE
 | ..| .   .. .|||| .    |. ||||           .  .|||| ..   . .| .|... |. .|||.||||.  ..|| .| .  |  .||
spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif.epikde





subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 400-449 1.4e-09 32.2 In-house 1-50 (69) alignment
Range on Protein: 400-449
Range on HMM: 1-50/69.0
MLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQT
|.||||.| ||||||.|| . . .   |  .||   .. ||. |  ||  
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmn

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 647-723 2e-09 31.8 In-house 217-291 (297) alignment
Range on Protein: 647-723
Range on HMM: 217-291/297.0
ILEEMNKTQRRsgNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIV
 || ..  . |  |. ..||||  |||| .   . . ..| . . . ||  .|.  | |..  |||.||.. ....|
qleslraempr..nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 402-451 2.6e-09 31.3 In-house 2-51 (69) alignment
Range on Protein: 402-451
Range on HMM: 2-51/69.0
VHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTRA
||||.| ||||||.|| . . .   |  .||   .. ||. |  ||    
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmnen

subfamily_CG42327_pd Subfamily CG42327 654-726 3.3e-09 30.8 In-house 241-314 (319) alignment
Range on Protein: 654-726
Range on HMM: 241-314/319.0
TQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTE-GVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEIVQIY
. .|. .  .|||||| |||. .  |.  .|.. ..    .|. |.. | | ..  .|.|.|||. |. ... |
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 394-450 3.8e-09 30.8 In-house 225-281 (297) alignment
Range on Protein: 394-450
Range on HMM: 225-281/297.0
KPTKGPMLVHCSAGVGRTGTFMAIDMGLQQAEKEGGIDIISIINRMRQQRMFMVQTR
.| . ..||||||||||.|  .  |. |..  |.   |. .|.. .|.||  .||| 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 357-449 1e-08 28.9 In-house 215-329 (349) alignment
Range on Protein: 357-449
Range on HMM: 215-329/349.0
QPPLMITQYHFTSWPDHGVPEYATSILQFHRrIKNE----------YK-PTKGPMLVHCSAGVGRTGTFMAIDMGLQ---QAEKE--------GGIDIIS
. | .. |  .  |.| ..     ||||    .||.          ..     ..||||||| ||||... .|. |.     ..|           |.||
ekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

-IINRMRQQRMFMVQT
 |.| .|.||. ||| 
iivnelrkqrismvqn

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 517-637 3.2e-08 28.0 In-house 11-126 (130) alignment
Range on Protein: 517-637
Range on HMM: 11-126/130.0
QQPNYINAVYVDSYKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEKENDEevcykYWPT-EATEVIFGEYSIKLLNEELYDLYTERTIEIKNK
|. .|||| .|      . .. .. |.  |  .||||. .  |  .|.|   .|.||     |||  |  |    .  . | . . ..      .||...
qgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikasnleiesd

MKGgSRHKVVQYQITGWEPNGE
..  | . .  .||. |  .| 
lne.shqaltmfqisnwpsdgt

0038934 (Phosphotyrosine protein) phosphatases II 364-417 7.8e-08 27.7 In-house 81-135 (194) alignment
Range on Protein: 364-417
Range on HMM: 81-135/194.0
QYHFTSWPDHGVPEYATSILQFHRRIKNEYKP-TKGPMLVHCSAGVGRTGTFMAI
.|.   .||.|..     .|.| . ..  ..  ..|  .||| ||.|||||. | 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 188-271 8.3e-08 26.0 In-house 10-88 (440) alignment
Range on Protein: 188-271
Range on HMM: 10-88/440.0
KFGEFVADGHanNDEEFMKQYALFHNDLDKHEMTISVsQKNKPLNRFRNVLVYDDNRIILKPLpsHEGCQNDYINASFIDGYSS
 | ..| . .      |  ...|. . | .     |.  .||  ||.||.|.|| .|..|. .  .   ..||||||.|.|  |
dfadyvqnnr..rsrafedewsllpsglsqpsdiasl.pnnkvknryrnilaydhsrvmleev..kgvpdsdyinasyingies

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 526-727 4e-07 23.0 In-house 107-309 (346) alignment
Range on Protein: 526-727
Range on HMM: 107-309/346.0
YVDSYKERKAFIIAESPMF---STVRNFWKMIEDINVTAIVMLCQEKENDEEVCYKYWPTEATEVIFGEYSIKLLNEELYDLYTERTIEIKNKMKGGSRH
|.  ..  . .|.|. | .   | | .|| || . ..  . ..  .    .     .   .      |   |.    ..     | |||.  . .  |  
yfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvi

KVVQYqITGWEPNGEVTCHQAILMILEEMNkTQRRSGNTSIVVHCSDTVGRSAMFCAAATTINKCKTEGVIDVFQVLKSQRIQKPGSVQTVEQYKGIFEI
  |..  . |    .      |. .. ..  ....  |. . |      ||.  |  |  .||.       ......|. . |.||.|..  || .|. |
cqvhh.hapwkhlqqppktlpiikmihqfl.sekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai

VQIYL
|  |.
vfdyi

PTEN_1 364-414 1.8e-06 22.9 In-house 96-147 (196) alignment
Range on Protein: 364-414
Range on HMM: 96-147/196.0
QYHFTSWPDHGVPEYAtSILQFHRRIKNEYK--PTKGPMLVHCSAGVGRTGTF
.|.  ...|||.|  . ... . ..... ..  | ..  |||| ||.||.|| 
eylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtv

subfamily_PTPDC1_pd Subfamily PTPDC1 365-451 3.2e-06 21.7 In-house 85-163 (182) alignment
Range on Protein: 365-451
Range on HMM: 85-163/182.0
YHFTSWPDHGVPEYaTSILQFHRRIKNEYKptKGPMLVHCSAGVGRTGTFMAIDMGLQQAekeggIDIISIINRMRQQRMFMVQTRA
..  .|.|.||.   ..||.  . ..   .  .| . ||| || ||||  .|  .  ..      ..    |. .|..|   .||| 
vynfgwkDygvasl.eriLdivkvvafalq..egkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtre

subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 508-586 3.2e-06 18.9 In-house 57-136 (327) alignment
Range on Protein: 508-586
Range on HMM: 57-136/327.0
DNHRVVLKGQQPNYINAVYVDsyKERKAFIIAESPMFSTVRNFWKMIEDINVTAIVMLCQEK---ENDEEVCYKYWPTEATE
 . | || | . ...   ||    |   .|| ..|   . .  |..|    .  .| ||...     |.  || |.|||  .
rdnrrvlcgsdeeffpgqyvr..megaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleq

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 491-540 3.4e-06 21.1 In-house 44-94 (95) alignment
Range on Protein: 491-540
Range on HMM: 44-94/95.0
IASQNKDKNRSTQFLPPDNHRVVLKGQ-QPNYINAVYVDSYKERKAFIIAE
 .  |  |||  . .| |  ||||  . . .||||..|| |  ....| |.
sseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 493-567 8.6e-06 19.4 In-house 32-109 (332) alignment
Range on Protein: 493-567
Range on HMM: 32-109/332.0
SQNKDKNRSTQFLPPDNHRVVLKGQQ--PNYINAVYVDSYKERKAFIIAESPMFS-TVRNFWKMIEDINVTAIVMLCQ
 .| | ||  ..   |  || |  |.   .. || .|| | .. |.|.|..|.   |   ||.|. . . . |... .
lnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd