Gene AquePTP-sf1-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily AquePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP142_AA protein Get Run
AqueP142_AA_6-200 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 6-201 2.4e-118 384.9 In-house 1-169 (169) alignment 
Range on Protein: 6-201
Range on HMM: 1-169/169.0
HKGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINAnfvgsplypksyiiaqwpmentiptfwRMIWETNASVIVVL
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||                           ||||||||||||||
hkgynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl

GDTDDKNNFWPEKEDYQLHPAVILGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLFHHSLA
|||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||.|||.||||||||||||||||||||||||||
GdtddknnfwpekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvghlfhhsla
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 5-200 2.8e-118 384.8 In-house 1-169 (169) alignment 
Range on Protein: 5-200
Range on HMM: 1-169/169.0
IHKGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINAnfvgsplypksyiiaqwpmentiptfwRMIWETNASVIVV
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||                           |||||||||||||
ihkgynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivv

LGDTDDKNNFWPEKEDYQLHPAVILGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLFHHSL
|||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||.|||.|||||||||||||||||||||||||
lgdtddknnfwpekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvghlfhhsl
0046845 (Phosphotyrosine protein) phosphatases II 7-198 2e-37 124.5 In-house 4-193 (284) alignment 
Range on Protein: 7-198
Range on HMM: 4-193/284.0
KGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMED-LGSDYINANFVGSP-----LYPKSYIIAQWPMENTIPTFWRMIWETNAS
. . ||  .  .....   | | .| .|||    |.  |.||||... .|  .||||||..|  .      ..| .|..|.|..||.  ||||.|| |..
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

VIVVLGDTDDKNN-----FWPEKEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVihsyD-DDVTEHLSLFHYSTWPQNGVPQSPVHVGH
|||.| .......     .||...... .          . . |.. ... . . .   .|....    . .. . ..  ||| .|| .|||.|| .. .
vIVmltelvengrekcaqYwplegevlty..........gdftvtllseevkddytvrtleltnl....gytgesrtvthfhytswpdhgvppspedlle

LFHH
... 
flrl
0051299 (Phosphotyrosine protein) phosphatases II 12-196 4.6e-37 123.4 In-house 32-208 (288) alignment 
Range on Protein: 12-196
Range on HMM: 32-208/288.0
LKEFMKTieYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDK
| ..  .  ..   | | .| .|||    |.  |.||||. . .. |||||||...  . ... .|..|.|..||.  ||||.|| | .|||.| .....
llsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvel

N-----NFWPEkEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLF
.      .||. .... .          . . |.. ... . . .   .||. . .   |. . .   ||| .|| .|||.|| .. .. 
grekcaqYwpl.ggslty..........gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl
0050432 (Phosphotyrosine protein) phosphatases II 9-197 1.7e-36 121.6 In-house 48-224 (308) alignment 
Range on Protein: 9-197
Range on HMM: 48-224/308.0
YNELKEFMKtiEYNNFMAELTCNETKNRPAGPLAPSHTRVKLqrvmeDLGSDYINANFVGSP--LYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLG
..|| ..     .. . |.| .| .|||    |.  |.||||     | |||||||..|  .   .|. .|..|.|..||.  ||||.|| | .|||.| 
feellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLt

DTDDK-----NNFWPEKED--YQLHpavilgewytDSLYVRTDKVHPntsgVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLFH
.....       .||....  .. .          . . |.. ...      ..     . .  ..|. . ..  ||| .||  |||.|| .. ....
klvengrekcaqYwplelgggsley..........gkftvtllseev....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle
0040438 (Phosphotyrosine protein) phosphatases II 10-197 6e-36 119.7 In-house 22-199 (317) alignment 
Range on Protein: 10-197
Range on HMM: 22-199/317.0
NELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTD
.| ..... . ..  .||| .|  |||    |   |.||||. . .||.||||||..|  | ... .|..| |..||.  ||||.|| . .||| | ...
eefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLtele

DKN-----NFWPEkEDYQLHpavilgewytDSLYVRTDKVHPntsgVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLFH
...      .||. .... .          . . |.. ...      .|     . .  ..|. . ..  ||| .||  |||.|| .. ....
elgrekcaqYwpl.getlty..........gdftvtllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle
0047943 (Phosphotyrosine protein) phosphatases II 5-197 4.8e-35 116.7 In-house 14-193 (273) alignment 
Range on Protein: 5-197
Range on HMM: 14-193/273.0
IHKGYNELKEFMKtiEYNNFMAELTCNETKNRPAGPLAPSHTRVKLqrvmEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVV
... ...|... .  ...   |.| .| .|||    |.  |.||||    .| |||||||..|  . ... .|..|.|..||.  ||||.|| |..|||.
lleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

LGDTDDKNN-----FWPEKED--YQLHPAvilgewytdsLYVRTDKVHPntsgVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLFH
| .......     .||....  .. .            . |.. ...      ..     . . ..... . .   ||| .|| .|||.|. .. ....
LtelvelgrekcaqYwpleggelsltygk..........ftvtllseet....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefie
0043336 (Phosphotyrosine protein) phosphatases II 9-192 4.8e-35 116.8 In-house 23-195 (278) alignment 
Range on Protein: 9-192
Range on HMM: 23-195/278.0
YNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDT
..| .|...   ..  .|.| .| .|||    |.  |.||||. . .||.||||||..|  . .|. .|..|.|...|.  ||||.|| . ..||.| . 
llefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtel

DDKN-----NFWPekEDYQLHPAvilgewytdsLYVRTDKVHPNTSGVEGLFEVSMvihsYDDDVTEHLSLFHYSTWPQNGVPQSPVHV
....      .||  .... .            . |.. |.. .   .   .||..    . |. . .   .||  || .||| |. ..
velgrvkcaqYwp..ggsltygd..........ftvtllkeehlddytvrtlevtn....lgdgesrtvthyhylgwpdhgvpeslsll
0036941 (Phosphotyrosine protein) phosphatases II 20-197 1.5e-34 115.1 In-house 28-195 (297) alignment 
Range on Protein: 20-197
Range on HMM: 28-195/297.0
EYNNFMAELTCNETKNRPAGPLAPSHTRVKLqrvmEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNN-----F
 ..   |.| .| .|||    |.  ||||||    .| |||||||..|  . ... .|..|.|..||.  ||||.|| | .|||.| . ....      .
lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WPEK-EDYQLHpavilgewytDSLYVRTDKVHP--NTSGVEGLFEVSMVihsyDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLFH
||.. .... .          . . |.. .|.   ... .   .||...    ... . ..  ||| .|| .|||.|| .. ....
wpleegeslty..........gdftvtllsvevvllddytlrtlevtdt....gngesrtvthfhytgwpdhgvpespaslldfie
subfamily_PTPRD_pd Subfamily PTPRD 11-195 1.9e-34 114.3 In-house 28-202 (564) alignment 
Range on Protein: 11-195
Range on HMM: 28-202/564.0
ELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDD
| |.. .  . .   |.  .|  ||| |  .|  |.||.|..|  | |||||||.|. .   .|.|| .| |...||  ||||.|| | |.|| |  . .
eykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleE

KNN-----FWPEK--EDYQLHPAVILGEWYTDSLYVRTDKVHPNTsgveglfevsmvihsydDDVTEHLSLFHYSTWPQNGVPQSPVHVGHL
|..     .||||  | |.     .  |       .|| |.. ..                 .. .     ||.  ||..|||.|. .. .|
kgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk.................ssesreVrqFhFtsWPdhgvpesatslLdl
0039614 (Phosphotyrosine protein) phosphatases II 11-196 2.7e-34 114.4 In-house 37-209 (297) alignment 
Range on Protein: 11-196
Range on HMM: 37-209/297.0
ELKEFMKTIEyNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVME-DLGSDYINANFVGSPLY-PKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDT
| .| .. .. .   |.| .| .|||    |.  |.||||. ... ||.||||||..|  . . .. .|..|.|...|.  ||||.|| . .||| | ..
efeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtkl

DDKN----NFWPEKEDyqlhpavilgewYTDSLYVRTDKVHPntsgV----EGLFEVSMvihsydDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLF
....     .|||...            . . . |.. ||.             .||..      .. . ..  |.|  || .|||.|. .. ...
velgrkcaqywpeegg............tygdftvtllkveh....ldgytvrtlevtn......ngesrtvthfqytgwpdhgvppslelllefl
DSPc_SM00195 12-197 5.2e-34 113.1 In-house 9-185 (263) alignment 
Range on Protein: 12-197
Range on HMM: 9-185/263.0
LKEFMKTIeyNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDK
|.|  ..   .   ||   |..|||    |   ||||||..  .. ||||||||..  . ..|.||..|.|...|.  ||||.||.. ..||.| . ...
leestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

-----NNFWPEKEdyqlhpaviLGEWYTDSLYVRTDKVHPNTsgvEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLFH
     ...|||..          |..  ... | . .|.      . .    . .   ... |  .  ..| .||..|||.|. .| .|..
gkekcdrywpees.........ggketfgkisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellr
PTPc_SM00194 12-197 5.2e-34 113.1 In-house 9-185 (263) alignment 
Range on Protein: 12-197
Range on HMM: 9-185/263.0
LKEFMKTIeyNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDK
|.|  ..   .   ||   |..|||    |   ||||||..  .. ||||||||..  . ..|.||..|.|...|.  ||||.||.. ..||.| . ...
leestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

-----NNFWPEKEdyqlhpaviLGEWYTDSLYVRTDKVHPNTsgvEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLFH
     ...|||..          |..  ... | . .|.      . .    . .   ... |  .  ..| .||..|||.|. .| .|..
gkekcdrywpees.........ggketfgkisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellr
0045450 (Phosphotyrosine protein) phosphatases II 5-198 2.8e-33 111.4 In-house 29-223 (307) alignment 
Range on Protein: 5-198
Range on HMM: 29-223/307.0
IHKGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMED-LGSDYINANFV--------GSPLYPKSYIIAQWPMENTIPTFWRMIW
..| ...|... ... ..  .|.| .| .|||    |.  ||||||. . ..  .||||||..|        ...  .. .|..|.|...|.  ||||.|
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlw

ETNASVIVVLGDTDDKNN-----FWPEKEDYQLHPAvilgewytdsLYVRTDKVHPntsgVEGLFEVSMVIHSY-DDDVTEHLSLFHYSTWPQNGVPQSP
| . .||| | .......     .||...... .            . |.. ...      .|.    . .. .  .. . ..  ||| .||  |||.|.
eqgvtvivmltelvelgrekcaqywPdegeeltygn..........ftvtllseeh....ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsf

VHVGHLFHH
 .. .... 
eelldfiee
subfamily_PTPRG_pd Subfamily PTPRG 6-202 4.5e-31 102.7 In-house 22-215 (563) alignment 
Range on Protein: 6-202
Range on HMM: 22-215/563.0
HKGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGS-DYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVV
.. ...|.. ... . .  ... ..|  |||    .|  ..||||. . .  .. ||||||..      | .|..| |...|.  ||||||| |...||.
seefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivm

LGD-----TDDKNNFWPEkEDYQLHPAVILGEWYTDSLYVRTDKvhpntsgvegLFEVS-MVIHSYDD-DVTEHLSLFHYSTWPQNGVPQSPVHVGHLFH
. .       . . .||. .. .   |. .  . .. | . | .           . .  . ..  .. |   .   .||..||. |||.... |    .
itnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvr..........tlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk

HSLAA
.| ||
kssaa
0042113 (Phosphotyrosine protein) phosphatases II 26-192 2.4e-30 101.2 In-house 4-160 (245) alignment 
Range on Protein: 26-192
Range on HMM: 4-160/245.0
AELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN-----NFWPEkED
|.| .| .|||   .|.  ||||||. . .||.||||||..|. . ... .|..|.|...|.. ||||.|| . ..|| | ......      .||. ..
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

YQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVihsyDDDVTEHLSLFHYSTWPQNGVPQSPVHV
.. .          . . |.. ... . . .   .||...     || . .   .||  || .||| .. ..
slty..........gdftvtllseehlddytvrtlevtnl....gddesrevihyhylpwpdhgvpdllell
0040439 (Phosphotyrosine protein) phosphatases II 24-199 4.8e-30 100.4 In-house 4-169 (249) alignment 
Range on Protein: 24-199
Range on HMM: 4-169/249.0
FMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDK-----NNFWPEk
 .|.| .|  |||    |.. |.||||. . .  .||||||...  . ... .|..|.|...|.. ||||.|| . .||| | ... .       .||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

EDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVihsyDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLFHHS
.... .          . . |.. .|. . . .   .|....     |. . .   ..|  ||  |||.|. ..  ...  
ggsley..........gdftvtllsvevkddytvrtleltnl....ydgesrtvlhiqytdwpdhgvppsfedlldfieav
0045098 (Phosphotyrosine protein) phosphatases II 25-197 5.4e-30 100.1 In-house 27-183 (278) alignment 
Range on Protein: 25-197
Range on HMM: 27-183/278.0
MAELTCNETKNRPAGPLAPSHTRVKlqrvmedlgsDYINANFVGSPlyPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN-----NFWPEkE
 | . .|  |||    |.  |.|||          |||||... ..  || .|..|.|...|.  ||||.|| . .||| | .  ...      .||| .
palylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.g

DYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSP--VHVGHLFH
... .          . . |.. ... .   .   ..|  . .   |. . ..  .|| .|| .||| .|   .. .|. 
gslty..........gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflelle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 20-198 2.5e-29 97.4 In-house 35-203 (318) alignment 
Range on Protein: 20-198
Range on HMM: 35-203/318.0
EYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN-----NF
.  .. .   .|..||| |  ||  ||||||| . .. ||||||||..      |.|| || |. .||. ||||.|| |..|||.| .. ..      ..
tvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhry

WPEKedyqlhpavilGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMvihsYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLFHH
||.|           |    ..| |  ..    .. |   |.|.      . . . .   .|| .||..|||.|.... .|  .
WPsk...........gsrsygklvvelkeevelsdyvlrefkvtr....teeeesrqvrqyhytsWpdegvpesgaslldlvrq
subfamily_PTPRB_pd Subfamily PTPRB 7-192 3.2e-29 96.9 In-house 29-201 (293) alignment 
Range on Protein: 7-192
Range on HMM: 29-201/293.0
KGYNELKEFMKTIEynNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLG
. |.|||.. |. .    .|||..|..|||    |.  |.||||. . .. ||||||||..     |. .| .| |. .|.  ||||.||...|.||.| 
eeyeelkavgkdqa..vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmlt

DTDDK-----NNFWPEKedyqlhpavilgewYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSydDDVTEHLSLFHYSTWPQNGVPQSPVHV
.. .|     ...||..              ... ||        ... .|     .. |.   .. ....  .|. .||. |||...  .
qlvekgkvkCeeYWPad..............eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktl
subfamily_Ptp69D_pd Subfamily Ptp69D 8-191 5e-29 96.4 In-house 27-203 (307) alignment 
Range on Protein: 8-191
Range on HMM: 27-203/307.0
GYNELKEFmkTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGD
 |..|..   .|. .  ..|   |  |||     |  .|||||...  .  ||||||.|. .    |..|.|| |.|.||  |||||.| .  .||.| .
eyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsn

TDDKNN-----FWPEKEDYQLHpavilgewytdSLYVRTDKVHPNTSGVEGLFEVSMVI-HSYDDDVTEHLSLFHYSTWPQNGVPQSPVH
 ..||.     .||. .  |             .. |.. . .  .  ..  ..||..  .| . . . ..  .|| .|.   ||...  
lteknrkkcakYWpiedevqyg...........dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 25-196 2.8e-28 94.2 In-house 19-175 (284) alignment 
Range on Protein: 25-196
Range on HMM: 19-175/284.0
MAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGdTDDKNNFWPEKEDYQlh
 |.|  |  |||    ||  ...|||.|..   .|||||| |.     .. || .| |..||.  ||||||| |.| ||.|   |   ..|| | . .  
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.kdkcsqywplkivik..

pavilgewyTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddvTEHLSLFHYSTWPQNGVPQSPVHVGHLF
          .   |. | |.     |   .|.|   .  |     ..  ||.  ||. |||..|...  | 
.........eerfkvkvdsveeseeyvvrdielsedgkekd...irkirqfhflgwpdvgvpdypsdlmrlv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 25-196 2.8e-28 94.1 In-house 55-211 (319) alignment 
Range on Protein: 25-196
Range on HMM: 55-211/319.0
MAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGdTDDKNNFWPEKEDYQlh
 |.|  |  |||    ||  ...|||.|.    .|||||| ||     .. || || |..||.  ||||||| |.| ||.|   |   ..|| | . .  
fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.kdkcsqywplkivik..

pavilgewyTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddvTEHLSLFHYSTWPQNGVPQSPVHVGHLF
          .   |. | |.     |   .|.|   .  |     ..  ||.  ||. |||..|. .  | 
.........eerfkvkvdsveetaeyvvrdielsedgkekd...irkitqfhflGwpdvGvpdypsdlmrlv
Y_phosphatase Protein-tyrosine phosphatase 31-192 3.2e-28 94.1 Pfam-A 1-155 (235) alignment 
Range on Protein: 31-192
Range on HMM: 1-155/235.0
NETKNRPAGPLAPSHTRVKLqrvM-EDLGSDYINANFV-GSPlYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDK-----NNFWPEKEDYql
|..|||    |.  .|||||     ..  |||||||.| | .  .|..|..| |...||  ||||.|. . .|||.| . ..|     ...|||.|.   
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..

hpavilgEWYTDSLYVRTD---------------KVHPNTSGVeglfevsmvihsydddVTEHLSLFHYSTWPQNGVPQSPVHV
       . ..... |..                ... ...                   ..... .|| .||..|||.|| ..
.......sltygdikvelkekekedekeytlrklelkkkkees................ekrevkqlhytnWpdhgvpespksl
Y_phosphatase Protein-tyrosine phosphatase 31-192 3.2e-28 94.1 In-house 1-155 (235) alignment 
Range on Protein: 31-192
Range on HMM: 1-155/235.0
NETKNRPAGPLAPSHTRVKLqrvM-EDLGSDYINANFV-GSPlYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDK-----NNFWPEKEDYql
|..|||    |.  .|||||     ..  |||||||.| | .  .|..|..| |...||  ||||.|. . .|||.| . ..|     ...|||.|.   
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..

hpavilgEWYTDSLYVRTD---------------KVHPNTSGVeglfevsmvihsydddVTEHLSLFHYSTWPQNGVPQSPVHV
       . ..... |..                ... ...                   ..... .|| .||..|||.|| ..
.......sltygdikvelkekekedekeytlrklelkkkkees................ekrevkqlhytnWpdhgvpespksl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 8-192 1.8e-27 91.4 In-house 32-207 (298) alignment 
Range on Protein: 8-192
Range on HMM: 32-207/298.0
GYNELKEFMKTIEYN-NFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLG
 ...|..  ..|| .   .|. . |. ||| |  .|  ..|| |... .|  |||||| |. .    ...|..| |...|.  ||||..| ....||.| 
efqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmlt

DTDDK-----NNFWPEK--EDYQlHPAVilgewytdslyvrtdKVHPNTSgVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHV
.. ..     ...||..  | |  .  |               ... . .    |  . . ..... . ....  .|...||..|||.    |
nleeldktkyhkywPdegketyg.eitv...............sllskee.fadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 25-191 5.2e-26 86.4 In-house 35-191 (281) alignment 
Range on Protein: 25-191
Range on HMM: 35-191/281.0
MAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN-----NFWPEKE
 ..   | .|||     |  .||||...  |.  .|||||||| .   .| ||..| |. ... .||.|.||...|.||..    ...      .||...
askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn

DyqlhpavilgEWYTDSLYVRTDKVHPNTSGVEGLFEVSMvihsyDDDVTEHLSLFHYSTWPQNGVPQSPVH
           |     . |.. . . ... .|  |....     ..  | ... ..| .||..|||... .
s..........elkygdvtvkstaeeekatyierkfkler.....esgetreveqlaytaWPdhGvPattke
0037934 (Phosphotyrosine protein) phosphatases II 25-199 7.8e-26 86.5 In-house 4-162 (243) alignment 
Range on Protein: 25-199
Range on HMM: 4-162/243.0
MAELTCNETKNRPAGPLAPSHTRVKLqrvmEDlgSDYINANFVGSPlyPKsYIIAQWPMENTIPT----FWRMIWETNASVIVVLGDTDDKNN-----FW
.| | .| .|||  . |.  |.||||    |.  |||||||..  .  |. .|. |.|...|.      ||||.|| . .||| | ......      .|
iallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PekedyqlhpavilGEWYTDSLYVRTDKVHPntsgVEGLFEVSMVIHSYD-DDVTEHLSLFHYSTWPQNGVPQSPVHVGHLFHHS
|             ||.. . . |.. ...      ..     ...  .| ||.| .   .||  || .|||.|| ..  .... 
p.............gevtygdftvtllseeh....lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldev
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 11-196 7.9e-26 85.9 In-house 31-204 (319) alignment 
Range on Protein: 11-196
Range on HMM: 31-204/319.0
ELKEFMKTieyNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDD
.|||  ..   .   |.   |..|||    ||  .|||.|. . .  |||||||.|. .    . .| .| |.||||  ||||.|| ..|..|.| .  .
llkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklve

KNNFWPEKedyqlhpAVILGEWYTDSLYVRTDKVHPNTSGVEglfEVSMVIHSYDDDV-TEHLSLFHYSTWPQNGVPQSPVHVGHLF
| .   .|            .. .   .. | . . ......      . ..   ..| | ... |.|  ||...||..   . .|.
klkvklkk.......ywpeenfeeyGrlivtleeeeeledyi...irklklnkkssevetRevkhfqyteWpdhdvPekatslldll
subfamily_PTPN9_pd Subfamily PTPN9 5-195 1.4e-25 85.0 In-house 18-198 (297) alignment 
Range on Protein: 5-195
Range on HMM: 18-198/297.0
IHKGYNELKEFMKtiEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVV
..| | |...     | .  ...| .| .||| .  |   .|||.|..| ||  |||||||||     .|..| .| |...|.  ||||.|| .. |||.
lskeyaeirnepv..eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivm

LGDTDDKN-----NFWPEKEDYQLHpavilgewYTDsLYVRTdkVhpNTSGVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHL
   . ..      ..||..|. . .        ..| | |..  |  ..   |   . ...|.  ... . ... | . .||  |||.|   . ..
ttrvvergrlkcgqyWpleeessae........fgd.lsvsn..v..eveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldv
subfamily_PTPN23_pd Subfamily PTPN23 6-192 2.3e-25 84.0 In-house 18-193 (288) alignment 
Range on Protein: 6-192
Range on HMM: 18-193/288.0
HKGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQrvmeDLGSDYINANFVGS--PLYPkSYIIAQWPMENTIPTFWRMIWETNASVIV
.| ..||..  .    .. .|   .. .|||    |   |.||||.    .   ||||| || .  |  | ..|..| |...|.  ||.|..|  .||||
dkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviV

VLGDTDDKN-----NFWPEKEDY-QLHPAvilgewytdsLYVRTDKVHPNtsgvEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHV
.| . ....     ..|||...  . ...          | |   .|.      |   |  . ..  | | ....|. .. .||. |||.|| ..
mllskeelgkpkvdrYwPedkgetvkfgd..........lsvtlksvret....ethvervlkletldadavksvshlqltsWpelGvPasPetl
subfamily_PTPRK_pd Subfamily PTPRK 25-188 3.2e-25 83.6 In-house 37-191 (314) alignment 
Range on Protein: 25-188
Range on HMM: 37-191/314.0
MAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN-----NFWPEKE
 |    |..|||    ||. ..||.|. . .|  ||||||... |   |. .|..| |...|.  |||.... |.. ||.| .  ..      ..|||. 
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

DYQLHpavilgewytdsLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDdvTEHLSLFHYSTWPQNGVPQS
.   .            . |   ......  |  .| |. . .....  .  .  |.. .||. .||.|
evygd............ikvelvetellaelvvrifrveklargqee..irevrqfqflgWpdhdvPvs
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 11-189 1.1e-24 82.2 In-house 27-197 (305) alignment 
Range on Protein: 11-189
Range on HMM: 27-197/305.0
ELKEFMKTiEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLG----
. |..... |  ... . . |..||| . .    . |..|.   ..  ||||||..| .    |.||.|| |..||.  |||.|.|.  |.|| |     
qykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklve

-DTDDKNNFWPEKEDYQLHpavilgewYtDSLYVRTDkvhpNTSGVEGLFEVSMVIHSYD-DDVTEHLSLFHYSTWPQNGVPQSP
 . |  . .|||.. .. .        . ... |       ... .....|  . |   | |. .  .. ..  .||..||||..
ggkdkCrqYWpesktekke........f.gefsvelk....sektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfa
subfamily_PTPN1_pd Subfamily PTPN1 18-194 1.2e-24 81.5 In-house 19-186 (290) alignment 
Range on Protein: 18-194
Range on HMM: 19-186/290.0
TIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEdlgsDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN-----
. ...   |.|  | ..||        |.|.||.|       |||||..|  .   .|||..| |. ||.  ||.|.|| ..  .|.|    .|.     
asdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

NFWPEKEDyqlHPAVILGEWYTDSLYVRTDKVHPNTSGVEGLFEvsmvihsYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGH
..||..|.   . ...| .      ...... .  |  .  | .          . | ... ||| |||  |||.||    .
qywPqgee...ekellledtklkvkliseerksyytvrllelen.......lktqetreilhfhyttwpdfgvpespaaflk
subfamily_PTPN6_pd Subfamily PTPN6 7-193 5.4e-24 79.7 In-house 30-209 (306) alignment 
Range on Protein: 7-193
Range on HMM: 30-209/306.0
KGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQrVMEDLGSDYINANFVG--SPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVV
. ..||..  ..  ..   .. . |..|||    |   ||||.|.   .  ||||||||..   ..   |||| .|  .|.|.. ||||.|. |. |||.
eefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivm

LGDTDDK-----NNFWPEKEDYQLHPAVILGEWYTDslyvrtdkvhpntSGVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVG
.    ..       .||..|. . .  . . .   .             |  .  .   .| .  ... . ..  .|. .||..|||..| .| 
ttkevErgkekCarYWPdeeekeeyGkisvtnvsek.............sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 14-199 6.2e-24 79.5 In-house 10-190 (274) alignment 
Range on Protein: 14-199
Range on HMM: 10-190/274.0
EFMKtIEYNN--FMAELTCNETKNRPAGPLAPSHTRVKLQR-VMEDLGSDYINANFVGSP-LYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTD
||.. .  |      ... ..||||    |  ...|| |..   ||  |.|||||..  .    | |. .| |. ||.  |||||......|||.| .  
efle.lPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklk

DKNN-----FWPEKEDYQLHPAVILGEwytdslyVRTDKVHPNTSgveglFEVSMVIHSYDDDvTEHLSLFHYSTWPQNGVPQSPVHVGHLFHHS
..|.     ..|..|||...   .  |       ....|.  .       ..|  .. .|  . . ..  . |. || . .|... .. .| .. 
eaneqkCavyfPdaedyeiserygdve.......ikvekivernd.....ysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvlev
subfamily_CG7180_pd Subfamily CG7180 18-188 6.9e-24 79.0 In-house 28-199 (296) alignment 
Range on Protein: 18-188
Range on HMM: 28-199/296.0
TIEYNNFMAELTC-NETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNN---
..| ..  ..|   |  |||    . . ..|| |...  .  |||||| .| | | .| ||. ..|...|.  |||.... ..| .||| .| | ..   
rleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmyp

-FWPEKEDYQLHPAVIL--GEWYTDSLYVRTDKVHPNtsgveglfEVSMVIHSYDDDVT-EHLSLFHYSTWPQ-NGVPQS
 .||.|   |  . ..    |     |  || |.  .         |..  .  . ..    . ||.. .|.  . || |
sywpnkskeqygeifveiveekqyanlkirtfkltkk........ivalteqekqvkaetRivklfqlteWeledkvPls
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 6-190 8.5e-24 79.1 In-house 24-195 (288) alignment 
Range on Protein: 6-190
Range on HMM: 24-195/288.0
HKGYNELKEFMKTIEynNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVL
.. || | .. || .  . ...|. |..|||    |.  ..||||. . |  |.|||||... .    | || .| |. .|.  ||....|...| || |
seeynsLaalektks..vtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml

GDT-----DDKNNFWPEKEDYQLHpavilGewytdSLYVRTDKVHPNTSGVEGLFEVSmvihsyDDDVTEHLSLFHYSTWPQNGVPQSPV
 .         ...||.... ...     |     |. |   ...  .. |.  ...        .    ..  ..| .||..|||.|  
telveggktkCeeYWPdadkpkny.....G.....svtvtlveskeledfvlrkllle......kkkteleitqyqylaWpdhgvPeska
subfamily_PTPN12_pd Subfamily PTPN12 17-194 2.4e-23 77.4 In-house 26-194 (290) alignment 
Range on Protein: 17-194
Range on HMM: 26-194/290.0
KTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNN---
.  .|.. ..| . | .|||    |   ..||.|..  |. |||||||||.  .  ...|| || |. .|.  |||||||.| ...|..    . .    
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

--FWPEKEDYQLHpavilgewyTDSLYVRTDKVHPNTSGveglFEVSMVIHSYDdDVTEHLSLFHYSTWPQNGVPQSPVHVGH
  .|||. . .|.         .... | ... .  . .    | . ..    . . . ..  |||  ||  |||.|. .. .
erYWpeegeeele.........fgefevtleeekavddd....flirtLkveaq.kesrkvyqfhYtaWPDhgvPssakslle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 26-193 2.8e-23 77.4 In-house 4-160 (250) alignment 
Range on Protein: 26-193
Range on HMM: 4-160/250.0
AELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNNFwpekeDYQLHP
|.   |. ||| |  .|  ..|| |...  |  |||||| |. .    |..|..| |...||  ||||..| ....||.| .  ....        |  |
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.....yhqywP

aVILGEWYTDslyVrtdKVHPNTSGVEGLFEVS-MVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVG
 |   | | |   |   .|..  . . . ...  ... ..      ..  .|. .||  |||.    | 
.vekaekyGd...v...tvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavL
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 27-194 2.9e-23 77.3 In-house 45-199 (315) alignment 
Range on Protein: 27-194
Range on HMM: 45-199/315.0
ELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNN-----FWPEKedy
  . |  |||    .|  ..||.|  .  | .|||.||||.    ... || || |  ...  |||...| . . ||.| .. ....     .||.|   
kkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...

qlhpAVILGEWYtdslYVRTDKVHPNTSGVEGLfevSMVihsYDDDVTEhLSLFHYSTWPQNGVPQSPVHVGH
     || |.        | .. . .   |  |   |.|   ..|.. | .  .||..||. |||.. . . .
....kviyGkit....vtrkseevnteytvrtl...svv...fgdnire.vvqlhytswpdmgvpkytiplmn
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 7-187 1.9e-22 74.4 In-house 14-185 (287) alignment 
Range on Protein: 7-187
Range on HMM: 14-185/287.0
KGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRvMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVL-
| .. |||  ..  .    || . .  ||| |  |   .||| |     .|||||||||.| |    ...| || |.  |.  |||...||........ 
kevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmt

---GDTDDK-NNFWPEKEDyqlhPaVILGeWYTDSLYvRTDKVHPNtSGVEGLfevsMVIHSyDDDVTEHLSLFHYSTWPQNGVPQ
    ..  |  ..|||.|     | . .|  |.  |    |. .|.  ||  |     .|.  .   .. .  ... .||..... 
reveearlkcykywPerev....P.mrvG.Gysvvll.dydikePe.ygvral....rlidl.etrearvvkqldllswPdkvlaP
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 23-189 8.7e-22 72.4 In-house 12-171 (270) alignment 
Range on Protein: 23-189
Range on HMM: 12-171/270.0
NFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVG-SPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN-----NFWP
. . | . ... || |. |   .|||.|... ||  . |||||.|      .|.|| |. |...|.  |||||||.... ||.. .  .|.      .||
sdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

EkedyqlhpavilgeWYTDSLYVRTDKVHPNT---SGVEGLFEVSMVIHsyDDDVTEHLSLFHYSTWPQNGVPQSP
.                 ... ... |..  .   .  ||     . ..  ..  ...|  |.| |||..|||...
a..............epkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpree
subfamily_ptpA1_pd Subfamily ptpA1 28-190 2e-21 71.2 In-house 44-206 (418) alignment 
Range on Protein: 28-190
Range on HMM: 44-206/418.0
LTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSpLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNNFwpeKEDyQLHPAV
   | .||| .  |   ||||.|... .  ||||||||..    ||| .| .| |. |||  ||||.||  . .||.|    ..      | | .  |  
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencri...kcd.rywpeq

ILGEWYtdSLYVRTDKVHPNTS--GVEGLFEV-----SMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPV
| || .  |.|   ..|    |   || . .      .  |.   .  |  .. ..|  ||.  .|.   
iggeqf..siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtq
subfamily_PTPRA_pd Subfamily PTPRA 25-191 2.7e-21 70.8 In-house 52-212 (330) alignment 
Range on Protein: 25-191
Range on HMM: 52-212/330.0
MAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNnfwpEKEDYQLH
.|.   |. |||    |   ..|| |. .     |||||| |.      ...| || | |.|.  ||||||| ... ||.| . ....    |.  .|  
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerk....eekcaqyw

PAVilGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVH
|    | .    . |  ...    .     | |  . .. ... .  .. ||. .||. |||  |. 
Pde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 10-187 3.1e-21 70.8 In-house 30-194 (297) alignment 
Range on Protein: 10-187
Range on HMM: 30-194/297.0
NELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYpkSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTD
.|..   ..  ... .||   |  |.| .  |     ||||. | .|  |||.|| || .  .   .|  | ||..|.  ||.|... ..|.||.| | .
eeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddn

DKNN----FWPEKEDYQlhpavilgewyTDSLYVRTDKVHPntsgVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQ
....    .|..|   .             .. | .  |.      ||  . ....   .  ..  .  ...  ||.. |..
erdkkcaryWsdkgvtt...........fGdvsvvllsvse....reGfikrelevtkgkakarrvvkqyqfveWPdkaver
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 21-188 4.8e-20 66.6 In-house 34-191 (315) alignment 
Range on Protein: 21-188
Range on HMM: 34-191/315.0
YNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTD--DK---NNFW
|..  |  | | .|||    |   ..||||. . ..  |||||| .. |    |.|| .| | . ..  ||||....... ||.. . .  ||   ...|
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PEKEDYqlhpAVILGewytdSLYVRTDKVHPNTSGVEglfeVSMVIHSYDDdvTEHLSLFHYSTWPQNGVPQS
|...      .| .|     |. | . .....| ||       .|.   ..  .. .. |..  ||..||.. 
Pdrkad....svefG.....sikvellsleadtdgva....rklvtrksee..srtvtqfqftewPdkGvdkq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 29-195 1.8e-19 64.5 In-house 46-199 (439) alignment 
Range on Protein: 29-195
Range on HMM: 46-199/439.0
TCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNNFWPEKEDyqlhpaVi
  ..||||     |  |||| || .     | |||||..     .| || .| | ..|  .|||...| ... ||.| .  .  ..|| ...      | 
eydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesykywpsdae......v.

lgeWYTDsLYVRTDKVHPNTSGVEGLFEVsmvIHSYDDDVTEH-LSLFHYSTWPQNGVPQSPVHVGHL
    | | . ||.|.       |   | |   .   |    |. .  ||| .||.. ||    || ..
...cygd.iavrvdrnielpnyvirgfkv...fnerdttekertvlqfhyiawpdknvpaqashvldf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 30-187 1.9e-19 64.8 In-house 46-191 (287) alignment 
Range on Protein: 30-187
Range on HMM: 46-191/287.0
CNETKNRPAGPLAPSHTRVKLQrvmeDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNN-----FWPEKEdyqlh
 |. ||| .  | |   || |.    .   ||||| |. .    | .|||. || ||.  ||..|.. | ..||.| .  ....     .|||..     
qnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeek.....

pAVILGEWYTdSLYvrTDKvhPNTSGVEGLFEVSmviHSYDDDVTEHLSLFHYSTWPQNG-VPQ
 .|.|||.   .|    ..   |.. .|  .||    ..  .. ....  ... .|...| |..
.svvlGeyni.ell..nee..vnagyierklevk...nknkagdkqqvkqyqitnWdstgkvte
subfamily_PTPRN_pd Subfamily PTPRN 7-190 1.7e-18 61.4 In-house 33-207 (297) alignment 
Range on Protein: 7-190
Range on HMM: 33-207/297.0
KGYNELKEFMKTiEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSP-LYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVL
| .. |...    .  . .|.   | .||| .  |.  |.||||..  ..  |||||| ..        .|| .| |. .|.  ||.|.||  . ||| |
kewealcayeae.pstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

GDTDD-----KNNFWPEKEDYQLHpavilgeWYTdsLYVRTDKVHPntsgvEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPV
   ..      ...||..     |        |   . . ....       .  .  |. .   . . |  .. ||. .||..||| |. 
trleeegvkqckrywpdeGsevyh.......iye..vhlvsehiwc.....ddylvrsfylknlqtsetrtvtqfhflswpeegvPasak
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 21-188 1.8e-18 61.0 In-house 33-190 (515) alignment 
Range on Protein: 21-188
Range on HMM: 33-190/515.0
YNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDT--DDKN---NFW
| . .|.   | .|||    |    .||||. . ..  |||.|| .. |    |.|| .| | . ..  |||.... | . |... .   .||    ..|
ypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyW

PEKEDYqlhpAVILGEWYTDSLyvrtdKVHPNTSGVEglfeVSMVIHSYDDdvTEHLSLFHYSTWPQNGVPQS
|.|       .| .|.   . .      ..  | |.       . .   ||  .  .  ||.  ||..|||. 
Pdkpgd....svkfGsikvelv.....sleactggik....rkltvlkgdd..srtvtqfhfteWPdkGvpkh
0049772 (Phosphotyrosine protein) phosphatases II 22-194 1.8e-18 62.8 In-house 37-201 (314) alignment 
Range on Protein: 22-194
Range on HMM: 37-201/314.0
NNFMAELTCNETKNRPAGPLAPShTRVKLqRVMEDLGSDYINANFVGSPlypKSYIIAQWPMENTIPTF----------WRMI--WETNASVIVV-----
   .| | .| .|||    |    .||.|   ..  |||||||..| ..   ...|..|.|.|.|.  |          |||.  .. |  .||      
tilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------LGDTDDKNNFWPEKEDYQLHpavilgewytdslyvrtdkvhpntsgveglfevsmvI-------HsydddvTEHLSLFHYSTWP
                | . | ..|......  .|.                                                   ...   ...  .|
ladelsrLdaAlgKtpllildgngneptaadlellk....................................eelydpelf......erlgikylripvp

QNGVPqSPVHVGH
 ...| .. .. .
Dgsap.lledfde
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 25-192 2.2e-18 61.5 In-house 42-200 (325) alignment 
Range on Protein: 25-192
Range on HMM: 42-200/325.0
MAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN----NFWPEKed
.| .  |  |||    .|  ..|| |.   .|  ||||||... .    . .. || |. .||  .||.. . ..||.|||   | ..     .||..  
vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpke..

yqLHPAVILGewytdSLYVRTDKVHPNTSGVEGLFEVSMVihsyDDDVTEHLSLFHYSTWPQNGVPQSPVHV
  .  .. .|     .| |.   .   .  |   ..|  |    ..  |  .  |.. .|.. ||.. |  .
..mgksktfG.....glevklrtieeisdyvhrvldvkqv....kkGetrsvkqfqlqswddmGvqkrpatl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 13-188 2.9e-18 60.5 In-house 27-150 (392) alignment 
Range on Protein: 13-188
Range on HMM: 27-150/392.0
KEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN
...     |.. .|.   |  |||    |    .||||. . .   |||.|| .. |    |.|| .| |   ..  ||||... |.. |... . .. .
hdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd

nfwpekedyqlhpavilgewytdslyvrtdkvhpntsgveglfevsmvihsyDDDVTEHLSLFHYSTWPQNGVPQS
                                                      | .   . ||.. ||...||. 
....................................................kgddartvaqfhftewPdkdvpkh
subfamily_PTPN3_pd Subfamily PTPN3 17-195 4.5e-18 60.1 In-house 27-196 (280) alignment 
Range on Protein: 17-195
Range on HMM: 27-196/280.0
KTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEdlgsDYINANFVGSPLY----PKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN
|  . .  .| .. | .|||    |.  .|||||.        ||||||.|   .      . ||..| |...|   ||.|.|| ..|.||.| .. .. 
kkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverG

-----NFWPEKEDYQlhpavilgeWYTdSLYVRTDKVHPNTSGVeglfEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHL
     ..|||.|| .          |. .. |.  | . ..| |       .|..  . .   ..  . |  ||..|||... .. ..
rvkChqyWPetedel.........eyg.efsvkcekedetksyv....lrelvlkdketkeerkilqlqylaWpdhgvPddsadflef
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 26-194 5.3e-18 59.9 In-house 41-202 (290) alignment 
Range on Protein: 26-194
Range on HMM: 41-202/290.0
AELTCNETKNRPAGPLAPSHTRVKLQRVME--DLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNN-----FWPEK
.  . |...|| |  . .   |. |... .  |   .|||| ..      |.||..| |..||.  ||..||. . ..||.| .  ....     .||..
gltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds

EDYQLHPAV-ILgewytdslyvrtdkvhPNTSGVEGLFEVSMVIHSYDD-DVTEHLSLFHYSTWPQNGVPQSPVHVGH
.  .. .    |                 | . ...  |  . ... .  . ....  .. ..|...|  . |  . .
dtkaygefsikl................lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill
subfamily_PTPN14_pd Subfamily PTPN14 16-189 6.3e-18 59.8 In-house 33-202 (300) alignment 
Range on Protein: 16-189
Range on HMM: 33-202/300.0
MKTI-EYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEDlGSDYINANFVGSPLY--PKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDT----
.|   . .   |.|  |. |||    |   ..||.|.   |.  ..||||  .  ..    .|||.|| |.|.|.  ||.|.||.. ..|| | ..    
pkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedg

-DDKNNFWPEKEDyqLHPAVILGEWYTDSLYVrTDKVHPNTSGveglFEVSMVIHSYDDDVTehlsLFHYSTWPQNGVPQSP
 .   ...|..|.   .  |  |..   . .. .|     |.|    ...  .  . . .|      . |  ||..|||. .
keksfkyfPkles..kkktvefgkfkvttkfs.edsdsvittg....lklkhlpskeertvw....hlqytDWpdhgvPeDv
subfamily_PTPN13_pd Subfamily PTPN13 8-195 2e-17 58.4 In-house 16-191 (273) alignment 
Range on Protein: 8-195
Range on HMM: 16-191/273.0
GYNELKEfMKTIEyNNFMAELTCNETKNRPAGPLAPSHTRVKLQrvmeDLGSdYINANFVGSPLYPK--SYIIAQWPMENTIPTFWRMIWETNASVIVVL
 ..||.| .|... .  ...   |..|||    |   .|||||.    | |. ||||...  |.  .  .||..| |. .|.  ||.|.|| .|.||...
efkelre.lkpld.tcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

GDTDDKN-----NFWPEKEDYQLHpaviLgewyTDSLYVRTDKVHpntsGVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHL
    .|.      .|||... .|     .    .. | |.  ||       .|.   .. ..  .   ..... ... .||  |||.|.... ..
tlekekgkvkchrywPesknkklk....v....snrlevellkvq....kldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 24-187 2.4e-17 57.7 In-house 25-181 (297) alignment 
Range on Protein: 24-187
Range on HMM: 25-181/297.0
F-MAELTCNETKNRPAGPLAPSHTRVKLQRVMEdlGSDYINANFVGSPLYPK--SYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTD----D-KNNFW
| .|       |||    ||   |||||.||.   ..|||||..|  |  ..   ||.|| |...|.  ||....| .  |||..        |    .|
fssakrnsslrknryrdilatddtrvkllrvit..erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PEKEDYQLHPAVILGEWYTDSlYVRTDKVHpntsgvegLFEVSMvIHSYDDDVTEHlslFHYSTWPQNGVPQ
|. .. .|. . .. |. ..      |.|.        | |. . |.  .  |  |     . .||. ||| 
psvvqerlkagdvvveflsst.sdefdrvi........ltelql.iyrsesrvvrh...vqflswpdhGvps
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 30-185 2.4e-17 57.4 In-house 95-235 (244) alignment 
Range on Protein: 30-185
Range on HMM: 95-235/244.0
CNETKNRPAGPLAPSHTRVKLQRvmEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNNFWPEKEDYqlhpavil
 |  ||| .  |     || | .    .|  |||| |||       ||..| |. .|   ||.|. |    |.||||  ......||. |          
nnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpdsepl........

gEWYTDSLYVR-TDKvhpntSGVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGV
 ||| . . |  ||.          .    . | |  ..  . |..|  | || .| 
.ewyeeditvtltdr.....defknikasnleiesdmneshqaltmfqisnwpsdgt
0041856 (Phosphotyrosine protein) phosphatases II 31-191 4.6e-17 57.6 In-house 1-97 (182) alignment 
Range on Protein: 31-191
Range on HMM: 1-97/182.0
NETKNRPAGPLAPSHTRvklqrvmedlGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGdtddKNNFWPekedyqlhpavilg
| .|||    | . |.|          ..||||||.. ..|... .|..|.|. .|.. |.||..| . ..|| |       . ||              
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywp..............

ewytdslyvrtdkvhpntsgveglfevsmvihsydDDVTEHLSLFHYSTWPQNGVPQsPVH
                                   .... .   ..|  || .|||  . .
...................................ellerlgiqylylpwpDhgvpd.lde
subfamily_CG42327_pd Subfamily CG42327 32-191 1e-16 55.5 In-house 29-182 (319) alignment 
Range on Protein: 32-191
Range on HMM: 29-182/319.0
ETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSP-LYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN-----NFWPEKEDYQLHp
. |.| .  .   .||| |||. .|  . |..|..|  .   | ||| || ..|..   |||..|| .. ||| | |  ..      ...| ||  . . 
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt.

avilgEWYTDslYVRTDKvhpNTSGVEGLFEVSMVIHSYDDDVTEHLSLFHYsTWPQNGVPQSPVH
     . | |  .  | |   .    .  .  .....  |.. . .|. . |  |.. .|| ..  
.....slyGd..ilvtlk...grevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaa
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 31-190 4.5e-16 53.8 In-house 3-153 (237) alignment 
Range on Protein: 31-190
Range on HMM: 3-153/237.0
NETKNRPAGPLAPSHTRVKLQRVMEDlgSDYINANFVG-SPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNN-----FWPEKEDyqlh
|. ||| .   |  |.|| |.    .  ||||||...      ||.|| || |.|..   ||.|.|. . ||||.|    ..|.     .||. ..    
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq....

PAViLGEwYTDSLYVRtDKVHPNTsgVEGLFevsmVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPV
||   |  .| ||  . ..    |  |  |     . . .       .  .....||..||||   
paa.ygv.ltvslkkk.eefsdyt..vrsll....lskrltlkevrlihqyqftswpdrgvpqqta
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 35-189 6.8e-16 52.8 In-house 46-207 (301) alignment 
Range on Protein: 35-189
Range on HMM: 46-207/301.0
NRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDK-----NNFWPE--KEDYQLHPA-
..   ..   .  .| .. ..    .||||... .    | .|.|| ||..|.  |||.||.   . ||.. .....     ...||.  .|...  |  
fknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpft

VILG-EWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddVTEHLSLFHYSTWPQNGVPQSP
| |  |    .  .|  .|. . .  .| .| .. ..|     . ..  ..   |||.|| . |
vtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvrep
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 21-191 2.8e-15 51.1 In-house 37-195 (288) alignment 
Range on Protein: 21-191
Range on HMM: 37-195/288.0
YNNFMAELTCNETKNRPAGplapSHTRVKLQrvmeDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNNfwPEKED
 ..|.|. | .  .| |        |||||.    |    ||.|| | |  |..  | || |.. ||  .|.|. |..   ||.| .  .|    .. ..
idsfianptrdryenlprc....ditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGk..eksae

YqlHPAVIlGEWYTDSLYvrTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQS---PVH
|   | .. ||      .     |  . .... | .||..  |   . .  .   |.  |...|||..   |..
y..fPskl.Gekarigrl..ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplr
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 29-191 9.3e-15 49.4 In-house 6-158 (239) alignment 
Range on Protein: 29-191
Range on HMM: 6-158/239.0
TCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGS-PLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNnfwpEKEDYQLHPAV
  |..||| |  ..  |.|| |... .|  ||||||...      ||.|| .|  .| .   ||||.|.    |||.|    .      .|. .|  |  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltgliegh....kkkchqywpds

IlgEWYTdSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddvtEHLSLFHYSTWPQNGVPQSPVH
     |   | |   |    .  .   | .| | .. .     ..  .|.. ||..||||    
t..skyc.nlrvtlrktevfadyiirtfvmsqvgqtee....ryvyqyhftvwpdkgvpqyata
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 29-191 9.3e-15 49.4 In-house 5-157 (239) alignment 
Range on Protein: 29-191
Range on HMM: 5-157/239.0
TCNETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFVGS-PLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNnfwpEKEDYQLHPAV
  |..||| |  ..  |.|| |... .|  ||||||...      ||.|| .|  .| .   ||||.|.    |||.|    .      .|. .|  |  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltgliegh....kkkchqywpds

IlgEWYTdSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddvtEHLSLFHYSTWPQNGVPQSPVH
     |   | |   |    .  .   | .| | .. .     ..  .|.. ||..||||    
t..skyc.nlrvtlrktevfadyiirtfvmsqvgqtee....ryvyqyhftvwpdkgvpqyata
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 31-188 1.4e-14 48.5 In-house 37-185 (281) alignment 
Range on Protein: 31-188
Range on HMM: 37-185/281.0
NETKNRPAGPLAPSHTRVKLQRVME-DLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNNfwpEK-EDYqlHPAVI
|. ||| .   .   .||.|.  |     .||| ||.. ||.  . ||..| | ..|   ||||||. |.. ||.| .  . |    ||  .|   |   
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnr...ekcaey..fprna

LGEWYTDSLYVRTDKVHPNTSGVEGLFEVsmvihSYDDDvTEHLSLFHYSTWPQNGVPQS
      | | |  .    | | |   ...     ||. . |  .. . .  ||.  ||.|
hcclqfdklsvsyedstvnkslvttrlnl.....syege.trlithwlwkewpdwqvpes
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 29-188 1.5e-14 48.4 In-house 53-206 (305) alignment 
Range on Protein: 29-188
Range on HMM: 53-206/305.0
TCNETKNRPAGPLAPSHTRVKLQRVMedlGSDYINANFVGSPLYP-KSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNNFwpekEDYQLHPAV
  ..|||| .   .  .. |||..      |||| ||.|| |. | | .| || |...||  || |. . .   ||.|  | .  ..       |  || 
diaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgkl....kcaqywpaa

iLGEWYTdslyVRTDKVHPNTSGVE-----GLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQS
  ||  .    ...  |  | ||          .....  .|  | .  .  .... ||. |||  
.qgekle....lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppc
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 29-154 1.6e-14 48.4 In-house 31-162 (283) alignment 
Range on Protein: 29-154
Range on HMM: 31-162/283.0
TCNETKNRPAGPLAPSHTRVKLQRVMEdlgsDYINANFVG---SPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDK-----NNFWPEK--
  |..|||    ..    ||.|.   .    ||||| |.    |    | ||||| |...|.  ||.|... ... ||.|    .        .||..  
denkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs

EDYQLHPAVILGEWYTDSLYVRTDKVHPNTSGVEGL
|||      .  |.  .|. ..   .. |.|  . |
edyGeftvtlrkettsnsfiikelllrvnssakstl
subfamily_egg_pd Subfamily egg 32-121 2e-14 48.0 In-house 41-133 (307) alignment 
Range on Protein: 32-121
Range on HMM: 41-133/307.0
ETKNRPAGPLAPSHTRVKLQRVMEDLGSDYINANFV-GSPLYpKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN---NFWPEKEDY
 .| |         .||||.        |.| || | | ||.   .|.|| |. ||   ||||... .   ||.|  . . .    .||  |. 
lekarskrvhckdssrvklelrrGqylddfihanrvkGkpll.nefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesd
0043147 (Phosphotyrosine protein) phosphatases II 58-195 2.7e-14 48.7 In-house 4-87 (172) alignment 
Range on Protein: 58-195
Range on HMM: 4-87/172.0
GSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTddknnfwpekedyqlhpavilgewytdslyvrtdkvhpntsgveglfev
|||||||...  .  |...|. |.|. ||.. ||||..| . ..|| | .                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

smviHSYDDDVTEHLSLFHYSTWPQNGVPqSPVHVGHL
      . ......   ..|  || .||| .. .. ..
....lydpellerlgiqylylpwpDhgvp.llelllef
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 26-189 7.3e-14 46.5 In-house 36-195 (307) alignment 
Range on Protein: 26-189
Range on HMM: 36-195/307.0
AELTCNETKNRPAGPLAPSHTRVKLQrvMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDK-----NNFWPEKED
  ...|  |||     .  ..|. ..  .. | |||| ||..|  . || .| || |.|||.  || |. . .   ...| .. .      ...|| .| 
eafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

YQLhpaVILGEWYTDSL-YVRTDKVHPNtsgvEGLFEVSMVIHSYDDdVTEHLSLFHYSTWPQNGVPQSP
 .|   |   .  | |.  . ..|. |.    | | .|. .   . .  .  .. . .. ||..||||  
qkl...vfgeapntisvanlgakklapd....edlinvttlkvdwaq.ksrtiqhlqwenwpdrgvpqin
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 50-184 1.7e-13 45.0 In-house 7-125 (130) alignment 
Range on Protein: 50-184
Range on HMM: 7-125/130.0
LQRVMedlGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNNFWPEKEDYqlhpavilgEWYTDSLYVRTDKVhpntS
..|.    | .||||.|||     . |. .| |. .|   ||.|. |    |.||||  ......||. | .         ||| . . | . .      
vsrlq...gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePl.........ewyeediivtltdr....d

GVEGLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNG
... .    . |.|   .  . |..|. | || .|
efknikasnleiesdlneshqaltmfqisnwpsdg
0036282 (Phosphotyrosine protein) phosphatases II 58-192 1.9e-13 45.9 In-house 1-88 (174) alignment 
Range on Protein: 58-192
Range on HMM: 1-88/174.0
GSDYINANFVGSPLYPKSYIIAQWPMEntiptFWRMIWETNASVIVVLGDTDDKN-----NFWPEkedyqlhpavilgewytdslyvrtdkvhpntsgve
|||||||....    .. .|. |.|..     ||.|..| . ...| | .   ..     |.|||                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

glfevsmvihsYDDDVTEHLSLFHYSTWPQNGVPQSPVhV
           . .| ...   ..|  || .||| ... .
...........lredlerlgiqylylpwpDhgvpdlsi.l
0046846 (Phosphotyrosine protein) phosphatases II 51-192 2.1e-13 45.9 In-house 4-95 (176) alignment 
Range on Protein: 51-192
Range on HMM: 4-95/176.0
QRVMEDLGSDYINANFVGSPLypksYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDK-----NNFWPEKEDYQLhpavilgewytdslyvrtdkvh
..  .||..||||||.. ...    .|. |.|...|...|..|..| . ...| | .  ..      |.||| |....                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

pntsgveglfevsmvihsydddvtehlsLFHYSTWPQNGVPQSpVHV
                             ...  || .|||..  ..
............................qylhlpwpDhgvpdl.ell
0051429 (Phosphotyrosine protein) phosphatases II 59-192 5.5e-13 44.7 In-house 4-140 (272) alignment 
Range on Protein: 59-192
Range on HMM: 4-140/272.0
SDYINANFVGSPLY---PKSYIIAQWPMENTIPTFWRMiWETNASVIVVLGDTD--DKNNFWPEKEDYQLHPAVILGEWYTDSLYVR-TDKVHPNTSGVE
|.||||..|| . .   |. .. .. |...|.  |||. .| . ..|| | ...  ........ .. ...   ||.. ... || . . ...  .    
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

GLFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPvhV
 .  . .... .. . . .. ..||  ||  ||||..  .
yilrellltlllsagearevmhlhytdwpdhgvpqea..l
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 31-118 1.2e-12 42.4 In-house 33-118 (267) alignment 
Range on Protein: 31-118
Range on HMM: 33-118/267.0
NETKNRPAGPLAPSHTRVKLQRVMEDlgsdYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGD--TDDKNNFWPEK
|. .||    |   .||| |.   |.    |||| .| .    . .|. | |..|||  |. .| . . .|||.|    ||. . ||| |
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 31-196 1.6e-12 41.8 In-house 48-212 (305) alignment 
Range on Protein: 31-196
Range on HMM: 48-212/305.0
NETKNRPAGPLAPSHTRVKLQRvmeDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN-----NFWPEKEDYQLHP
.. |||        . ||||.        .|| ||.| .|  || .| .| |.|.|   || | .. .   | .| .  .|      .... |.. .|. 
eagknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

AVilGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDvTEHLSLFHYSTWPQNGVPQSPVHVGHLF
    ..      .  . ... ...    . |  .||     . ... . .|.  ||. ||| . . .  |.
ee..kgqkisvkfessvtlkfrkdakakvtetvlviegpgek.arkvthyhwidwpdrgvpaadlailell
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 30-110 4.5e-11 36.9 In-house 51-130 (310) alignment 
Range on Protein: 30-110
Range on HMM: 51-130/310.0
CNETKNRPAGPLAPSHTRVKLQrVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDD
 .  ||| .  .    .||||. .      ||| ||.| .    ...| .| |.. ||  |||||..  |  |..|  . .
kymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvge
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 34-193 1.2e-10 35.6 In-house 53-204 (301) alignment 
Range on Protein: 34-193
Range on HMM: 53-204/301.0
KN-RPAGPLAPShTRVKlqrVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNNFwpEKEDY-QLHP--AVIL
|. .|. |  || | |.   |..|     | ||.. ..  |. .|..| |..||   || |.   .   ||.|| . .|..     |.|  ...   . .
khryptvPckPs.tave...vivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkveklee..kceeylpvkisekldi

GEWytdSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddvTEHLSLFHYSTWPQNGVPQSPVHVG
| .   .. ... ..  | . ..  .||      ..   |  .  . ||.|...|||.| ... 
grf...kikiknkelilnkkiskrtlevedstgkfa...trtvthyqysewtdrgvPkshaelf
0049260 (Phosphotyrosine protein) phosphatases II 71-192 5.8e-10 34.6 In-house 6-74 (152) alignment 
Range on Protein: 71-192
Range on HMM: 6-74/152.0
LYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKNNFWPEKEDyqlhpavilgewytdslyvrtdkvhpntsgveglfevsmvihsydddvte
 .|. .|..|.|..||.. ||||..| ....||.| . .... .. |.                                                    
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................

hlsLFHYSTWPQNGVPQSPVHV
    ...  || .|||... ..
...qylhlpwpDhgvpdlsqll
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 18-113 5.9e-10 33.1 In-house 21-115 (332) alignment 
Range on Protein: 18-113
Range on HMM: 21-115/332.0
TIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQrvMEDLGSDYINANFVGSPLYPKSYIIAQWPMEN-TIPTFWRMIWETNASVIVVLGDTDDKNN
.. | |   ..  |   ||     .  |.||.|    .|   |. ||..|       .||.|| |... |   ||||. | . |.|.|.|| |.|..
amtypntydkflnnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 74-195 7.8e-10 33.2 In-house 4-119 (198) alignment 
Range on Protein: 74-195
Range on HMM: 4-119/198.0
KSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDtDDKNnfwpeKE-DYQL-HPAVILGEWYTDSLYVRTDKVHPNTSgvEGLFEVSMVIHSYDDDVTEH
. || .| |. .|.  ||.|.||| .  ||.. | |.||     || || . .|..  |     || | |  .  .      .  . ..  .     |  
rryiatqhplretladfwqmvwetgsghivmvnd.dqkn.....keadypfywpttesgtgkygslsvttktittkpd..ytitaliltnnttappstre

LSLFHYSTWPQNGVPQSPVHVGHL
.| . ...| ..  |.  . || .
ishyqftswkekttpnvalfvgfv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 74-195 8.3e-10 33.2 In-house 5-120 (199) alignment 
Range on Protein: 74-195
Range on HMM: 5-120/199.0
KSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDtDDKNnfwpeKE-DYQL-HPAVILGEWYTDSLYVRTDKVHPNTSgvEGLFEVSMVIHSYDDDVTEH
. || .| |. .|.  ||.|.||| .  ||.. | |.||     || || . .|..  |     || | |  .  .      .  . ..  .     |  
rryiatqhplretmadfwqmvwetgsghivmvnd.dqkn.....keadypfywpttesgtgkygslsvttktittkpd..ytitaliltnnttappstre

LSLFHYSTWPQNGVPQSPVHVGHL
.| . ...| ..  |.  . || .
ishyqftswkekttpnvalfvgfv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 32-112 1.2e-09 32.4 In-house 48-142 (350) alignment 
Range on Protein: 32-112
Range on HMM: 48-142/350.0
ETKNRPAGPLAPSHTRVKLQRVM--------EDLGSDYINANFVGSP-----LYPKS-YIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN
 .|||    |   |.||||.. .           ..||||||..  .       |.  || .| |. .|.  |...| . .  ||. | . .. |
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 30-190 1.6e-09 31.8 In-house 55-203 (290) alignment 
Range on Protein: 30-190
Range on HMM: 55-203/290.0
CNETKNRPAGPLAPSHTRVKLQRVMEdlgSDYINANFVGSplYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDD-----KNNFWPEKEDYqlh
 . .|||         ||| |.   .    ||. ||.|        .|..| ....|.  .|||. ......||.| .  .      ....||||     
tefkknrykdvvcndktrvilkdGyd...GdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe...

pAVILGEWYTDSlyvrTDKVHPNTSGVEGlfevSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPV
 .. .||.        . . ....  .       . .   |.     |  ..  .||.. |..| .
.vltfGeitvlc....seeddkdaniikk....tlsvrdkdsGkehklkhlkikswpdksvalstl
0044763 (Phosphotyrosine protein) phosphatases II 45-191 8.8e-09 30.7 In-house 4-94 (178) alignment 
Range on Protein: 45-191
Range on HMM: 4-94/178.0
HTRVKLQRVMEDLGSDYINANFVGsplyPKsYIIAQWPMentiPTFWRMIWETNASVIVVLGDTDDK-----NNFWPEKEDyqlhpavilgewytdslyv
.|||.|. ..  ..||||||...     |  ......|.    . ......| . ..|| | ...       .  |||...                   
rtrvllsnleglersdyinaseil....pg.lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

rtdkvhpntsgveglfevsmvihsydddvtehlSLFHYSTWPQNGVPQSPVH
                                   ...  .| .|||... |
.................................iqylhipipDhgvpdlleh
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 33-124 1.2e-08 28.7 In-house 53-148 (302) alignment 
Range on Protein: 33-124
Range on HMM: 53-148/302.0
TKNRPAGPLAPSHTRVKLQRVMEdlgsDYINANFVGSPLYPKSYIIAQWPMENTI---PTFWRMIWETNASVIVVLGDTDDK-N---NFWP-EKEDYQLH
 ||.     .. ...|||.   .    .|.||  |  |   .| |.|| |  ..     .||||... .   .|.|  ...  .   ...| . .||. .
kknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykey
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 28-191 7e-08 26.4 In-house 44-194 (303) alignment 
Range on Protein: 28-191
Range on HMM: 44-194/303.0
LTCNETKNRPAGPLAPSHTRVKLQrvmeDlgSDYINANFVGSPLyPKSYIIAQWPMENTIPTFWRMIWETNASVI-VVLGDTDdKNNFWPEkedYQLHPA
.  |  ||| .  .   |..|||     |  | || |...      |  |..| |.  |   ||.|| | .  .. ..| |..  ...  .   . .   
fvknmdknrfvdvicldhskvkls....d..ssyihasylelds.skkailtqlplshtaadfwqmiieqkvkcvlllltdse.ydklggd...svfprn

VILGEWYTDslYVRTDKVHPnTSGVEGlFEVSmVIHSYDDDVTEHLSLFHYSTWPQNGVPQS--PVH
  . ..     ..|  . .     ..| . .  |.   . |    | . || .||.| .|    |  
qdflkfeer..sirvgefkr.velgdg.wvlk.vlsvsngdyksflhvhhykawphnsipsdgspkf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 30-196 1.4e-07 25.9 In-house 18-184 (290) alignment 
Range on Protein: 30-196
Range on HMM: 18-184/290.0
CNETKNRPAGPLAPsHTRVKLQRVMEDLGSDYINANFVGSPLyPKSYIIAQWPMEN-------TIPTFWRMIWETNASVIVVLGDTDDKNNFWPEKEDYQ
 .| ..| . ||.  .||| |.   . . .||| ||.|  |      |. | | |.       ||  || |. . ..  .| |.. ..|.. . ..   .
khemdqRlevpLve.atrvvLkgygkrfnddyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

LHPAVILGEWYTDSLYVRTdkvhPNTSGVEGlFEVSMVIHSYDDDVTEHLSLFHYSTWPQNGVPQSPVHVGHLF
  |  . .|   . | |.      .   ... .|.  ..  .||..   .    .. | .  |....  . .| 
YvpesvgeelkfkgltvkC....kskekedd.vetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsli
0051082 (Phosphotyrosine protein) phosphatases II 59-200 1.4e-07 26.7 In-house 3-88 (151) alignment 
Range on Protein: 59-200
Range on HMM: 3-88/151.0
SDYINANFVGSPlypksYIIAQWPMEntipTFWRMIWETNASVIVVLGDTD---DKNNFWPEKEdyqlhpavilgewytdslyvrtdkvhpntsgveglf
|||||...|..      ... ..|..     |.....| . ..|| | ...      ...|| .                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg....................................

evsmvihsydddvtEHLSLFHYSTWPQNGVPQSPVHVGHLFHHSL
               ..  ...  ||  |.|.|.  | ..... |
..............ievlhipildwpdpglplsfdavleflelll
subfamily_eak_pd Subfamily eak 47-108 2e-07 24.7 In-house 67-127 (332) alignment 
Range on Protein: 47-108
Range on HMM: 67-127/332.0
RVKLQRVMEDlGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDT
 |.|   . .    ||||  .  .   . ||..  . |. .. ||.|. | ..  || | . 
lvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlled
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 58-112 1.2e-06 22.1 In-house 89-145 (349) alignment 
Range on Protein: 58-112
Range on HMM: 89-145/349.0
GSDYINANFVGSPLY--PKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDTDDKN
  ||||||..  . .   | ||  | |.  |.  |...|   .  ... | | ....
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 61-110 1.4e-06 22.3 In-house 69-119 (312) alignment 
Range on Protein: 61-110
Range on HMM: 69-119/312.0
YINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVV-LGDTDD
|| ||||     |. ....| |.|||.  ||..     .. |..  |  .|
yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfved
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 54-105 1.5e-06 22.0 In-house 65-116 (347) alignment 
Range on Protein: 54-105
Range on HMM: 65-116/347.0
MEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVL
  |    ||||  .      | ||..|.|. .|.  ||.|.  |. . .| .
raddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti