Gene AquePTP-sf1-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily AquePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP143_AA protein Get Run
AqueP143_AA_0-189 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1-109 2.5e-77 251.4 In-house 61-169 (169) alignment 
Range on Protein: 1-109
Range on HMM: 61-169/169.0
MIWETNASVIVVLGDTDDKNNFWPEKEDYQLHPAVILGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHV
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||.|||||||||||||||||
miwetnasvivvlGdtddknnfwpekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhv

GHLFHHSLA
|||||||||
ghlfhhsla
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1-108 1.1e-76 249.4 In-house 62-169 (169) alignment 
Range on Protein: 1-108
Range on HMM: 62-169/169.0
MIWETNASVIVVLGDTDDKNNFWPEKEDYQLHPAVILGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHV
|||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||.|||.|||||||||||||||||
miwetnasvivvlgdtddknnfwpekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhv

GHLFHHSL
||||||||
ghlfhhsl
0046845 (Phosphotyrosine protein) phosphatases II 1-188 3.2e-22 74.7 In-house 96-274 (284) alignment 
Range on Protein: 1-188
Range on HMM: 96-274/284.0
MIWETNASVIVVLGDTDDKNN-----FWPEKEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVihsyD-DDVTEQLSLFHYSTWPQNGVP
|.|| |..|||.| .......     .||...... .          . . |.. ... . . .   .|....    . .. . ..  ||| .|| .|||
mvweqnvrvIVmltelvengrekcaqYwplegevlty..........gdftvtllseevkddytvrtleltnl....gytgesrtvthfhytswpdhgvp

QSPVHVGHLFHHSLAART----RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
.|| .. ....    ...     || |. . .| ||.|.. .. ...|.|.  ...  .|     . .... |  |||| | .  |. |....| |.|
pspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvd.....vleavkrlreqRpgmvqtleqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 1-188 7.1e-22 73.5 In-house 127-299 (308) alignment 
Range on Protein: 1-188
Range on HMM: 127-299/308.0
MIWETNASVIVVLGDTDDK-----NNFWPEKED--YQLHpavilgewytDSLYVRTDKVHPntsgVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGV
|.|| | .|||.| .....       .||....  .. .          . . |.. ...      ..     . .  ..|. . ..  ||| .||  ||
mvweqnvrvIvmLtklvengrekcaqYwplelgggsley..........gkftvtllseev....lddytvrtleltnlgdgesrtvthfhytnWpdhgv

PQSPVHVGHLFHHSLAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
|.|| .. .....    .  || |. . .| ||.|.. .. ...|.|..  ..         . .... |  |||| | .  |. |..|.| | |
PpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvd........vfeavkklReqRpgmvqtpeqylflyralleyl
DSPc_SM00195 1-186 2.1e-20 68.5 In-house 88-260 (263) alignment 
Range on Protein: 1-186
Range on HMM: 88-260/263.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEdyqlhpaviLGEWYTDSLYVRTDKVHPNTsgvEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.||.. ..||.| . ...     ...|||..          |..  ... | . .|.      . .    . .   ... | ..  ..| .||..|||.
mvweekvkiivmlteeeengkekcdrywpees.........ggketfgkisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpd

SPVHVGHLFHHSLAART--RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsfdadpNIIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
|. .| .|..     .    ||.|...  | ||.|.. ....... |.. ..          |..... |  ||||.| .. |. |..... |
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk........vdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 1-186 2.1e-20 68.5 In-house 88-260 (263) alignment 
Range on Protein: 1-186
Range on HMM: 88-260/263.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEdyqlhpaviLGEWYTDSLYVRTDKVHPNTsgvEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.||.. ..||.| . ...     ...|||..          |..  ... | . .|.      . .    . .   ... | ..  ..| .||..|||.
mvweekvkiivmlteeeengkekcdrywpees.........ggketfgkisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpd

SPVHVGHLFHHSLAART--RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsfdadpNIIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
|. .| .|..     .    ||.|...  | ||.|.. ....... |.. ..          |..... |  ||||.| .. |. |..... |
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk........vdifeivkelRkqRpgmvqtleqYlfiyeaile
0051299 (Phosphotyrosine protein) phosphatases II 1-187 1.2e-19 66.3 In-house 111-285 (288) alignment 
Range on Protein: 1-187
Range on HMM: 111-285/288.0
MIWETNASVIVVLGDTDDKN-----NFWPEkEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| | .|||.| ......      .||. .... .          . . |.. ... . . .   .||. . .   |. . .   ||| .|| .|||.
mvweqnvrvIvmltklvelgrekcaqYwpl.ggslty..........gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

SPVHVGHLFHHSLAA--RTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEEC
|| .. .. ..   |   . || |. . .| ||.|.. .. ...|.|.   ..         . .... |  ||||.| .  |. |....| |.
spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvd........vleavkrlreqRpgmvqtpeqyrfvyealley
0036941 (Phosphotyrosine protein) phosphatases II 1-188 2e-19 65.4 In-house 97-277 (297) alignment 
Range on Protein: 1-188
Range on HMM: 97-277/297.0
MIWETNASVIVVLGDTDDKNN-----FWPEK-EDYQLHpavilgewytDSLYVRTDKVHP--NTSGVEGLFEVSMVihsyDDDVTEQLSLFHYSTWPQNG
|.|| | .|||.| . ....      .||.. .... .          . . |.. .|.   ... .   .||...    ... . ..  ||| .|| .|
mvweqnvtvIvmltelvelgrekcaqywpleegeslty..........gdftvtllsvevvllddytlrtlevtdt....gngesrtvthfhytgwpdhg

VPQSPVHVGHLFHHSLAAR----TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
||.|| .. ....  . ..      || .. . .| ||.|.. .. .....|.   . . .|     | .... |  |||| | .  |. |....| | |
vpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd.....ileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 1-186 2.3e-19 65.3 In-house 96-270 (273) alignment 
Range on Protein: 1-186
Range on HMM: 96-270/273.0
MIWETNASVIVVLGDTDDKNN-----FWPEKED--YQLHPAvilgewytdsLYVRTDKVHPntsgVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGV
|.|| |..|||.| .......     .||....  .. .            . |.. ...      ..     . . ..... . .   ||| .|| .||
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygk..........ftvtllseet....kddytvrtleltnlgtgesrtvthfhytgwpdhgv

PQSPVHVGHLFHHSLAART----RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
|.|. .. .....   |.      || |. . .| ||.|.. .. .....|..  ..         ...... |  |||| | .  |. |....| |
ppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd........vleavkllrsqRpgmvqtpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 1-188 9.6e-19 63.2 In-house 105-276 (317) alignment 
Range on Protein: 1-188
Range on HMM: 105-276/317.0
MIWETNASVIVVLGDTDDKN-----NFWPEkEDYQLHpavilgewytDSLYVRTDKVHPntsgVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| . .||| | ......      .||. .... .          . . |.. ...      .|     . .  ..|. . ..  ||| .||  |||.
mvweqgvtvivmLteleelgrekcaqYwpl.getlty..........gdftvtllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvpp

SPVHVGHLFHHSLAA--RTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
|| .. ....   .|  .  ||... . .| ||.|.. .. ...|.|.   ..         ...... |  |||| | .  |. |....| | |
spdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd........veeavkelreqRpgavqtpeqyrflydalleyl
Y_phosphatase Protein-tyrosine phosphatase 1-184 4.7e-18 60.8 Pfam-A 61-233 (235) alignment 
Range on Protein: 1-184
Range on HMM: 61-233/235.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEDYqlhpavilgEWYTDSLYVRTD---------------KVHPNTSGVeglfevsmvihsydddVTEQL
|.|. . .|||.| . ..|     ...|||.|.          . ..... |..                ... ...                   ....
mvwqekvkvivmltsleekgrekcaqYwpeeeee.........sltygdikvelkekekedekeytlrklelkkkkees................ekrev

SLFHYSTWPQNGVPQSPVHVGHLFHHSLAAR--TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsfdadPNIIDsVFRGLLGQRPGLVANQRQFD
. .|| .||..|||.|| .. .| .     .  ..||.|... .| ||.|.. ..... | |.  ..       ... . . . |  ||||.| .  |. 
kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.......vdvlq.ivkelRkqRpgmvqsleqYi

FCHRIL
|.....
flykai
Y_phosphatase Protein-tyrosine phosphatase 1-184 4.7e-18 60.8 In-house 61-233 (235) alignment 
Range on Protein: 1-184
Range on HMM: 61-233/235.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEDYqlhpavilgEWYTDSLYVRTD---------------KVHPNTSGVeglfevsmvihsydddVTEQL
|.|. . .|||.| . ..|     ...|||.|.          . ..... |..                ... ...                   ....
mvwqekvkvivmltsleekgrekcaqYwpeeeee.........sltygdikvelkekekedekeytlrklelkkkkees................ekrev

SLFHYSTWPQNGVPQSPVHVGHLFHHSLAAR--TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsfdadPNIIDsVFRGLLGQRPGLVANQRQFD
. .|| .||..|||.|| .. .| .     .  ..||.|... .| ||.|.. ..... | |.  ..       ... . . . |  ||||.| .  |. 
kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.......vdvlq.ivkelRkqRpgmvqsleqYi

FCHRIL
|.....
flykai
0039614 (Phosphotyrosine protein) phosphatases II 1-185 1.4e-17 59.6 In-house 120-286 (297) alignment 
Range on Protein: 1-185
Range on HMM: 120-286/297.0
MIWETNASVIVVLGDTDDKN----NFWPEKEDyqlhpavilgewYTDSLYVRTDKVHPntsgV----EGLFEVSMvihsydDDVTEQLSLFHYSTWPQNG
|.|| . .||| | ......     .|||...            . . . |.. ||.             .||..      .. . ..  |.|  || .|
mvweqgvtvivmLtklvelgrkcaqywpeegg............tygdftvtllkveh....ldgytvrtlevtn......ngesrtvthfqytgwpdhg

VPQSPVHVGHLFHHSLAAR----TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILE
||.|. .. ....    |.      || .. . .| ||.|.. .   ..|.|.   ..         ...... |  |||| | .  |. |....| 
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd........vleavkelreqRpgavqtpsqyrflydall
subfamily_PTPRG_pd Subfamily PTPRG 1-189 1.5e-17 58.0 In-house 110-288 (563) alignment 
Range on Protein: 1-189
Range on HMM: 110-288/563.0
MIWETNASVIVVLGD-----TDDKNNFWPEkEDYQLHPAVILGEWYTDSLYVRTDKvhpntsgvegLFEVS-MVIHSYDD-DVTEQLSLFHYSTWPQNGV
|||| |...||.. .       . . .||. .. .   |. .  . .. | . | .           . .  . ..  .. |   .   .||..||. ||
miWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvr..........tlviknlklkkkkqcdteklvrqyhytkWPdhgv

PQSPVHVGHLFHHSLAARTR--GPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPqsfdadpNIIdSVFRGLLGQRPGLVANQRQFDFCHRILEECLW
|.... |    ..| ||. .  ||.|.   .|.||.| | |..   . ..  ..        |.   . . .  ||. ||... |. | | .| |.. 
PehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenav.......nvf.gflkhiraqRnflvqteEqYiflhdalleaia
0045450 (Phosphotyrosine protein) phosphatases II 1-186 3.4e-17 58.6 In-house 126-302 (307) alignment 
Range on Protein: 1-186
Range on HMM: 126-302/307.0
MIWETNASVIVVLGDTDDKNN-----FWPEKEDYQLHPAvilgewytdsLYVRTDKVHPntsgVEGLFEVSMVIHSY-DDDVTEQLSLFHYSTWPQNGVP
|.|| . .||| | .......     .||...... .            . |.. ...      .|.    . .. .  .. . ..  ||| .||  |||
mlweqgvtvivmltelvelgrekcaqywPdegeeltygn..........ftvtllseeh....ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvp

QSPVHVGHLFHHSLAAR----TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
.|. .. ....  ..|.      || .. . .| ||.|.. .  .....|.   | . .|     ...... |  |||| | |. |. |....| |
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd.....lleavkllreqRpgavqnpeqyrflyealle
0043336 (Phosphotyrosine protein) phosphatases II 1-185 6.1e-17 57.4 In-house 107-274 (278) alignment 
Range on Protein: 1-185
Range on HMM: 107-274/278.0
MIWETNASVIVVLGDTDDKN-----NFWPekEDYQLHPAvilgewytdsLYVRTDKVHPNTSGVEGLFEVSMvihsYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| . ..||.| . ....      .||  .... .            . |.. |.. .   .   .||..    . |. . .   .||  || .||| 
mvwelgvttivmLtelvelgrvkcaqYwp..ggsltygd..........ftvtllkeehlddytvrtlevtn....lgdgesrtvthyhylgwpdhgvpe

SPVHVGHLFHHSLAA--RTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILE
|. .. .. .  . |     ||... . .| ||.|.. .. ...|.|.   ..         ...... |  |||| | .. |. |....| 
slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd........leeavkelreqRpgavqtpsqyrflyeall
subfamily_PTPRD_pd Subfamily PTPRD 1-188 1.1e-16 55.7 In-house 110-281 (564) alignment 
Range on Protein: 1-188
Range on HMM: 110-281/564.0
MIWETNASVIVVLGDTDDKNN-----FWPEK--EDYQLHPAVILGEWYTDSLYVRTDKVHPNTsgveglfevsmvihsydDDVTEQLSLFHYSTWPQNGV
|.|| | |.|| |  . .|..     .||||  | |.     .  |       .|| |.. ..                 .. . .   ||.  ||..||
mvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk.................ssesreVrqFhFtsWPdhgv

PQSPVHVGHLFHHS--LAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
|.|. .. .| ...  |. ...||.|.    | || |.. |...  | ..     .  |     | .. . |  ||. .| .. |. |.|... | |
pesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerike...ektvD.....iyqyvkalrkqRnamVqteeQYiFiheaileal
0040439 (Phosphotyrosine protein) phosphatases II 1-186 6.8e-16 54.1 In-house 73-244 (249) alignment 
Range on Protein: 1-186
Range on HMM: 73-244/249.0
MIWETNASVIVVLGDTDDK-----NNFWPEkEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVihsyDDDVTEQLSLFHYSTWPQNGVPQ
|.|| . .||| | ... .       .||. .... .          . . |.. .|. . . .   .|....     |. . .   ..|  ||  |||.
mlwelgitvivmLtslvelgrekcaqywpl.ggsley..........gdftvtllsvevkddytvrtleltnl....ydgesrtvlhiqytdwpdhgvpp

SPVHVGHLFHHSLAAR----TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
|. ..  ...  . |.    . ||... . .| ||.|.. .   ..|.|.   .          ...... |  |||| | |. |. |....| |
sfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd........leeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 1-184 1.6e-15 52.7 In-house 71-239 (245) alignment 
Range on Protein: 1-184
Range on HMM: 71-239/245.0
MIWETNASVIVVLGDTDDKN-----NFWPEkEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVihsyDDDVTEQLSLFHYSTWPQNGVPQ
|.|| . ..|| | ......      .||. .... .          . . |.. ... . . .   .||...     || . .   .||  || .||| 
mlwelgittivmLteeeelgrvkcaqywpl.geslty..........gdftvtllseehlddytvrtlevtnl....gddesrevihyhylpwpdhgvpd

SPVHVGHLFHHSLAAR---TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRIL
.. ..  ...  . |.     ||... . .| ||.|.. ..  ..|.|.   .          ...... |  |||| | .. |. |....|
llellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs........leeavkelrsqRpgavqtpsqyrflyeal
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-192 2.6e-15 51.6 In-house 123-296 (319) alignment 
Range on Protein: 1-192
Range on HMM: 123-296/319.0
MIWETNASVIVVLGdTDDKNNFWPEKEDYQlhpavilgewyTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddvTEQLSLFHYSTWPQNGVPQSPVHV
|||| |.| ||.|   |   ..|| | . .            .   |. | |.     |   .|.|   .  |     ..  ||.  ||. |||..|. .
miweyncstivllt.kdkcsqywplkivik...........eerfkvkvdsveetaeyvvrdielsedgkekd...irkitqfhflGwpdvGvpdypsdl

GHLFHH--SLAAR--TRGPLVIVSAHGGGRAGCYGVVSVayeLLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHR-ILEECLWGVA
  | ..   |  .   | ..|.  . | ||.| | |. |   ||.. .  .  |     .  . |.|  ||. || .  |. |..  .||| |.| .
mrlvkkvrhltskenhranivvhcsaGvGrtGvyivldv...lldrmkeekqvd.....vynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-192 2.7e-15 51.6 In-house 87-260 (284) alignment 
Range on Protein: 1-192
Range on HMM: 87-260/284.0
MIWETNASVIVVLGdTDDKNNFWPEKEDYQlhpavilgewyTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddvTEQLSLFHYSTWPQNGVPQSPVHV
|||| |.| ||.|   |   ..|| | . .            .   |. | |.     |   .|.|   .  |     ..  ||.  ||. |||..|...
miweyncstivllt.kdkcsqywplkivik...........eerfkvkvdsveeseeyvvrdielsedgkekd...irkirqfhflgwpdvgvpdypsdl

GHLFHH--SLAA--RTRGPLVIVSAHGGGRAGCYGVVSVayeLLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRI-LEECLWGVA
  | ..   |    . | ..|.  . | ||.| | |. |   ||.. .  .  |     .  . |.|  ||. || .  |. |..   ||| |.| .
mrlvkkvrhltskenhranivvhcsagvgrtgvyivldv...lldrmkeekqvd.....vynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
0037934 (Phosphotyrosine protein) phosphatases II 1-184 2.7e-15 52.0 In-house 67-238 (243) alignment 
Range on Protein: 1-184
Range on HMM: 67-238/243.0
MIWETNASVIVVLGDTDDKNN-----FWPekedyqlhpavilGEWYTDSLYVRTDKVHPntsgVEGLFEVSMVIHSYD-DDVTEQLSLFHYSTWPQNGVP
|.|| . .||| | ......      .||             ||.. . . |.. ...      ..     ...  .| ||.| .   .||  || .|||
mlwelgitvivmltelvElgrekcaqywp.............gevtygdftvtllseeh....lddytvrtlllenldlddltrlvihyhylpwpdhgvP

QSPVHVGHLFHHSL----------AARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPdtpqsfdadpniIDSVFRGLLGQRPG-LVANQRQFDFCHRI
.|| ..  ....            |. . ||...   .| ||.|.. .  . ..||...            ...... |  ||||  | .. |. |....
dspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvd............leeavkllreqRpgkavqtpsqyrflyea

L
|
l
0045098 (Phosphotyrosine protein) phosphatases II 1-186 5.7e-15 50.9 In-house 83-270 (278) alignment 
Range on Protein: 1-186
Range on HMM: 83-270/278.0
MIWETNASVIVVLGDTDDKN-----NFWPEkEDYQLHpavilgewytDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| . .||| | .  ...      .||| .... .          . . |.. ... .   .   ..|  . .   |. .  .  .|| .|| .||| 
mlwelgitvivmltelvelgrekcaqywpe.ggslty..........gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvps

SP--VHVGHLFHHSLAAR---------------TRGPLVIVSAHGGGRAGCYGVVSVAYELLnmpdtPQSFDadpniIDSVFRGLLGQRPG-LVANQRQF
.|   .. .|.   ..|.                 || ..   .| ||.|.. ..   .|||     .. .|     ...... |  ||||  | |. |.
lpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.....eggvd.....lleavkelrsqRpglavqnleqy

DFCHRILEE
 |... | |
rflyeflle
subfamily_PTPRK_pd Subfamily PTPRK 1-192 6.7e-15 49.7 In-house 105-282 (314) alignment 
Range on Protein: 1-192
Range on HMM: 105-282/314.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDYQLHpavilgewytdsLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDdvTEQLSLFHYSTWPQNGVPQ
.... |.. ||.| .  ..      ..|||. .   .            . |   ......  |  .| |. . .....  . ..  |.. .||. .||.
lvydencasivmltelvevgrvkClkyWPedtevygd............ikvelvetellaelvvrifrveklargqee..irevrqfqflgWpdhdvPv

SPVHVGHLFHH--SLAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHR-ILEECLWGVA
|   . .| ..  .  . . |..|.    |.||.|.. ....  ....  ..    |     .  . . |  ... .|  . |. |..  ||| || | .
satgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregv...vd.....vfnavktlrsrkvnmveteeqykfiydvileaclcget
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-187 3.4e-14 47.6 In-house 110-282 (319) alignment 
Range on Protein: 1-187
Range on HMM: 110-282/319.0
MIWETNASVIVVLGDTDDKNNFWPEKedyqlhpAVILGEWYTDSLYVRTDKVHPNTSGVEglfEVSMVIHSYDDDV-TEQLSLFHYSTWPQNGVPQSPVH
|.|| ..|..|.| .  .| .   .|            .. .   .. | . . ......      . ..   ..| | ... |.|  ||...||..   
mvWeeessivvmltklveklkvklkk.......ywpeenfeeyGrlivtleeeeeledyi...irklklnkkssevetRevkhfqyteWpdhdvPekats

VGHLFHHSLAARTR---GPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFdadpniidSVFRGLLGQRPGLVANQRQFDFCHRILEEC
. .|...   .| .   ||.|.  . | || | . |.... | ..   .   |        |. . |  ||. .| .. |. |.. .| | 
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvf........stvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1-185 7.9e-14 46.4 In-house 92-265 (274) alignment 
Range on Protein: 1-185
Range on HMM: 92-265/274.0
MIWETNASVIVVLGDTDDKNN-----FWPEKEDYQLHPAVILGEwytdslyVRTDKVHPNTSgveglFEVSMVIHSYDDDvTEQLSLFHYSTWPQNGVPQ
||......|||.| .  ..|.     ..|..|||...   .  |       ....|.  .       ..|  .. .|  . . ..  . |. || . .|.
miyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdve.......ikvekivernd.....ysvrklvlkyler.ersvkhywytdWPdhksPd

SPVHVGHLFHHSLAART-----RGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtpqsfDADPNIIdSVFRGLLGQRPGLVANQRQFDFCHRILE
.. .. .| ..   .|.     ..| |.  . | ||.||.  .|.|   |.        .   ... ..   |  .| |.| .. |... ||.| 
dantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre.......eivvdvl.kivcnlrldrGGmvqtseqyelihralc
PTPc_DSPc_SM00012 81-184 8.9e-14 46.9 In-house 3-103 (105) alignment 
Range on Protein: 81-184
Range on HMM: 3-103/105.0
SLFHYSTWPQNGVPQSPVHVGHLFHHSLAART----RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDtpqsfdaDPNIIDSVFRGLLGQRPGLVANQRQ
. .||..||. |||... .. .|...    ..    ..|.|... .| ||.|.. ....... |.          .   |  ... |  ||||.| ...|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.......kevdifqivkelrkqRpgmvqteeq

FDFCHRIL
. |..|.|
ylflyral
subfamily_PTPN23_pd Subfamily PTPN23 1-183 9.3e-14 45.9 In-house 102-275 (288) alignment 
Range on Protein: 1-183
Range on HMM: 102-275/288.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDY-QLHPAvilgewytdsLYVRTDKVHPNtsgvEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVP
|..|  .||||.| . ....     ..|||...  . ...          | |   .|.      |   |  . ..  | | ....|. .. .||. |||
mvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd..........lsvtlksvret....ethvervlkletldadavksvshlqltsWpelGvP

QSPVHV------GHLFHHSLAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDT-PqsfdadpNIIDsVFRGLLGQRPGLVANQRQFDFCHRI
.|| ..       .  ...   ... |||.    | ||.| . .|  | . |.  .  .       .||. |.. |  ||   | .. |. |.  .
asPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngll.......diiq.vvsrlreqRrfmvqekeqlkfsyea
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-189 1.8e-13 45.3 In-house 108-281 (318) alignment 
Range on Protein: 1-189
Range on HMM: 108-281/318.0
MIWETNASVIVVLGDTDDKN-----NFWPEKedyqlhpavilGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMvihsYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| |..|||.| .. ..      ..||.|           |    ..| |  ..    .. |   |.|.      . . . |   .|| .||..|||.
mvWeqnsavivmltqeeergkakvhryWPsk...........gsrsygklvvelkeevelsdyvlrefkvtr....teeeesrqvrqyhytsWpdegvpe

SPVHVGHLFHHSLAAR---TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpnIIDSVfRGLLGQRPGLVANQRQFDFCHRILEECLW
|.... .|  .. .|    ..||.|.  . | ||.| . .|..  | ..   .         . . | . |  ||. .|  . |..|.. .| | | 
sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvD.......vfqtv.kqlreqrnlmvqtedqyefiydvlleala
subfamily_Ptp69D_pd Subfamily Ptp69D 1-186 2.6e-13 44.8 In-house 110-284 (307) alignment 
Range on Protein: 1-186
Range on HMM: 110-284/307.0
MIWETNASVIVVLGDTDDKNN-----FWPEKEDYQLHpavilgewytdSLYVRTDKVHPNTSGVEGLFEVSMVI-HSYDDDVTEQLSLFHYSTWPQNGVP
||.| .  .||.| . ..||.     .||. .  |             .. |.. . .  .  ..  ..||..  .| . . . ..  .|| .|.   ||
miaeqevtlivmlsnlteknrkkcakYWpiedevqyg...........dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP

QSPVHVGHLFHHS--LAARTRGPLVIVSAHGGGRAGCYGVVSVayeLLNMpdtpQSFDADPNIIDSVfRGLLGQRPGLVANQRQFDFCHRILEE
...  . .| ..   |    |.|.|.    | ||.| .  ...   ||.     .  .   .|.. | ..|  ||. || . .|. |..| | .
evargllklieqvrelyklnrsPivvhCsaGvgrsgifvalds...llqq....lkaedkvdifetv.kdLrsqRnllvqsleqYvflyralld
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-188 4.2e-13 44.2 In-house 118-290 (298) alignment 
Range on Protein: 1-188
Range on HMM: 118-290/298.0
MIWETNASVIVVLGDTDDK-----NNFWPEK--EDYQlHPAVilgewytdslyvrtdKVHPNTSgVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGV
|..| ....||.| .. ..     ...||..  | |  .  |               ... . .    |  . . ..... . ....  .|...||..||
mvteedigtiVmltnleeldktkyhkywPdegketyg.eitv...............sllskee.fadlivrklkvskkkeekerevrqlhftsWpdkgv

PQSPVHVGHLFHHSLA-ARTRG--PLVIVSAHGGGRAGCYGVVsvaYELLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
|.    | .| ..  |  .  |  |...  ..| ||.| . ..   . .|.   . |. |     .  | . |  .|||.|  ..|. |.. .  | |
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiai...dsvlervkkeqvvD.....vfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPN6_pd Subfamily PTPN6 1-186 9.5e-13 42.8 In-house 117-295 (306) alignment 
Range on Protein: 1-186
Range on HMM: 117-295/306.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEDYQLHPAVILGEWYTDslyvrtdkvhpntSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|. |. |||..    ..       .||..|. . .  . . .   .             |  .  .   .| .  ... . ..  .|. .||..|||.
mvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvsek.............sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpk

SPVHVGH----LFHHSL--AARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtpQSFDADPNIIDSVfRGLLGQRPGLVANQRQFDFCHRILEE
.| .| .    . ...   .... ||.|.  . | || | . |. .  .|..     . .||| .| ..| . .  || |||  . |. | ......
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliek....kgldadidiqklv.ksvreqrsglvqteqqykfvykaikk
subfamily_PTPRA_pd Subfamily PTPRA 1-190 1.3e-12 42.2 In-house 120-298 (330) alignment 
Range on Protein: 1-190
Range on HMM: 120-298/330.0
MIWETNASVIVVLGDTDDKNnfwpEKEDYQLHPAVilGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHV
|||| ... ||.| . ....    |.  .|  |    | .    . |  ...    .     | |  . .. ... . ... ||. .||. |||  |. .
miweqksativmltelkerk....eekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGm

GHLFHH--SLAARTRGPLVIVSAHGGGRAGCYGVVSvayELLNMPDTPQSFDadpnIIDSVfRGLLGQRPGLVANQRQFDFCHRILEEC-LWG
 .|...  .|  .. ||.|.  . | ||.| . |..    .|..  . .  |    . . | . |  ||| .|  . |. |....| |  |.|
lkllkkvkklnqqsagpivvhcsaGvGrtGtfivld...avlervkaerkvd....vfefv.krlrlqrpqmvqtdeqyefiykvlleyylyg
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-187 1.4e-12 42.4 In-house 108-282 (305) alignment 
Range on Protein: 1-187
Range on HMM: 108-282/305.0
MIWETNASVIVVLG-----DTDDKNNFWPEKEDYQLHpavilgeWytDSLYVRTDkvhpNTSGVEGLFEVSMVIHS-YDDDVTEQLSLFHYSTWPQNGVP
.|.|.  |.|| |      . |  . .|||.. .. .       .  ... |       ... .....|  . |    .|. . ... ..  .||..|||
liveekvstivmltklveggkdkCrqYWpesktekke.......f..gefsvelk....sektasdyieRklkisiededkesrtvlqyqltdWPdhGvp

QSPVHVGHLFHHSLAARTRG---PLVIVSAHGGGRAGCYGVVSVAYELLNMPDtpqSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEEC
|..  . .|...   .. ..   ||...   | ||.| . .|..| | |.  .   . |     .  | . |  .|...| .. |..|.| .|.| 
qfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEe...vvd.....vfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_PTPN13_pd Subfamily PTPN13 1-188 1.6e-12 42.3 In-house 96-269 (273) alignment 
Range on Protein: 1-188
Range on HMM: 96-269/273.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDYQLHpaviLgewyTDSLYVRTDKVHpntsGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| .|.||...    .|.      .|||... .|     .    .. | |.  ||       .|.   .. ..  .   ..... ... .||  |||.
mvweqkaeviamvtlekekgkvkchrywPesknkklk....v....snrlevellkvq....kldgfvvralavkdsesgesrevahlnfvkwPdhgvPs

SPVHVGHLFHHSLAAR-TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDtpqSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
|.... ..  .    .  .||.|.  . | ||.| . .. |. .|..      .||     .  . | |  || |.|  . |. |..... | |
saaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdk...efd.....vkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN1_pd Subfamily PTPN1 1-182 2.1e-12 41.4 In-house 90-265 (290) alignment 
Range on Protein: 1-182
Range on HMM: 90-265/290.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDyqlHPAVILGEWYTDSLYVRTDKVHPNTSGVEGLFEvsmvihsYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| ..  .|.|    .|.     ..||..|.   . ...| .      ...... .  |  .  | .          . | ... ||| |||  |||.
mvWeqkskavvmlnkvvekeqikcaqywPqgee...ekellledtklkvkliseerksyytvrllelen.......lktqetreilhfhyttwpdfgvpe

SPVHVGHLFHHS----LAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDADPNIIDsvfrgLLGQRPGLVANQRQFDFCHR
||    .....       ..  || ||  . | ||.| . .|     |..  |  .| |    ...     |  .| ||.  . |..| . 
spaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvlle.....lrkyrlGliqtadqlrfsyl
subfamily_PTPN12_pd Subfamily PTPN12 75-186 2.3e-12 41.4 In-house 167-275 (290) alignment 
Range on Protein: 75-186
Range on HMM: 167-275/290.0
DVTEQLSLFHYSTWPQNGVPQSPVHVGHLFHHS--LAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVA
. . ..  |||  ||  |||.|. .. .| ..   |  .   |||.  . | ||.|   ..  ..|||.   .|...|     . .. . |  ||. || 
kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeld.....vfdlvlelrkqraalvq

NQRQFDFCHRILEE
 . |. . .. ..|
tkeqyelvykavae
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-187 4.5e-11 37.4 In-house 103-275 (281) alignment 
Range on Protein: 1-187
Range on HMM: 103-275/281.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDyqlhpavilgEWYTDSLYVRTDKVHPNTSGVEGLFEVSMvihsyDDDVTEQLSLFHYSTWPQNGVPQ
|.||...|.||..    ...      .||...           |     . |.. . . ... .|  |....     ..  | ... ..| .||..|||.
mvweqkvsaivmvtreieagklkChrYWPddns..........elkygdvtvkstaeeekatyierkfkler.....esgetreveqlaytaWPdhGvPa

SPVHVGHlFHHSL----AARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNmpdtPQSFDADpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEEC
.. .. . |.. .      .|  ||||  . | ||.|.|  .  . . ..     .  ..|   .. | . |  .|  .|    |..| .... . 
ttkelle.frkevlkltekktkaplvihCsaGvGrtGtyialDrlvkave....aeleeld...vkavvaelrkernlmvqtvvqyefvykavlda
subfamily_CG7180_pd Subfamily CG7180 1-187 4.6e-11 36.9 In-house 104-289 (296) alignment 
Range on Protein: 1-187
Range on HMM: 104-289/296.0
MIWETNASVIVVLGDTDDKNN----FWPEKEDYQLHPAVI--LGEWYTDSLYVRTDKVHPNtsgveglfEVSMVIHSYDDDVTE-QLSLFHYSTWPQ-NG
.... ..| .||| .| | ..    .||.|   |  . ..  . |     |  || |.  .         |..  .  . .. .  . ||.. .|.  . 
lvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkk........ivalteqekqvkaetRivklfqlteWeledk

VPQS---PVHVGH---LFHHSL-AARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDAdpniidsvFRGLLGQRPGLVANQRQFDFCHRILE
|| |    ... .   |. .      ..||.|.||  |..|.| |  . .. ||..  .  . |.|         . |  .||.|| |  .. ..  .|.
vPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFea........vktlrrsRpqLvenveeYkyiYdvll

EC
| 
ea
0051429 (Phosphotyrosine protein) phosphatases II 3-191 1.1e-10 37.1 In-house 42-228 (272) alignment 
Range on Protein: 3-191
Range on HMM: 42-228/272.0
WETNASVIVVLGDTD--DKNNFWPEKEDYQLHPAVILGEWYTDSLYVR-TDKVHPNTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPvh
.| . ..|| | ...  ........ .. ...   ||.. ... || . . ...  .     .  . .... .. . . .. ..||  ||  ||||..  
kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..

VGHLFHHSLAartRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFDADPNIIDSVFRGLLGQRPGLVANQRQFDFCHRILEECLWGV
. .|... |.    ||...  ..| .| |.. ..   .. ... .  . .      .. . . |  |||| | .. |. |....| | | ..
llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_PTPRN_pd Subfamily PTPRN 1-183 1.3e-10 35.5 In-house 119-287 (297) alignment 
Range on Protein: 1-183
Range on HMM: 119-287/297.0
MIWETNASVIVVLGDTDD-----KNNFWPEKEDYQLHpavilgeWYTdsLYVRTDKVHPntsgvEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.||  . ||| |   ..      ...||..     |        |   . . ....       .  .  |. .   . . |  .. ||. .||..||| 
mvweqGvvvivnltrleeegvkqckrywpdeGsevyh.......iye..vhlvsehiwc.....ddylvrsfylknlqtsetrtvtqfhflswpeegvPa

SPVHVGHlFHHSL--AARTRG-PLVIVSAHGGGRAGCYGVVSVAYEllNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRI
|.  . . |   .  . | |  |.|. . .| ||.|.| .. .  .  ..    .  |     | .    |  ||||||. . ||.|.   
sakslle.frrkvnksyrGrscpivvhcsdGaGrtGvyilidlvln..rllkGvkeid.....iaatlehlrdqrpglvktkdqfefalta
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-188 2.3e-10 35.1 In-house 71-242 (250) alignment 
Range on Protein: 1-188
Range on HMM: 71-242/250.0
MIWETNASVIVVLGDTDDKNNFwpekeDYQLHPaVILGEWYTDslyVrtdKVHPNTSGVEGLFEVS-MVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPVH
|..| ....||.| .  ....        |  | |   | | |   |   .|..  . . . ...  ... ..      ..  .|. .||  |||.    
mvleeksgtivmLtnLkesekt.....yhqywP.vekaekyGd...v...tvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevata

VGHLFHHSLAARTR---GPLVIVSAHGGGRAGCYGVVSVayeLLNMPDTPQSFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
| .| ..  | . .   .|...  . | ||.|.. ...    .|.   . .  |     .  | . |  .||. |  . |. |...|. . |
vLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida...vlerlkkekvvd.....vfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-185 7.8e-10 33.3 In-house 109-276 (288) alignment 
Range on Protein: 1-185
Range on HMM: 109-276/288.0
MIWETNASVIVVLGDT-----DDKNNFWPEKEDYQLHpavilGewytdSLYVRTDKVHPNTSGVEGLFEVSmvihsyDDDVTEQLSLFHYSTWPQNGVPQ
...|...| || | .         ...||.... ...     |     |. |   ...  .. |.  ...        .    ..  ..| .||..|||.
lvyenktstivmltelveggktkCeeYWPdadkpkny.....G.....svtvtlveskeledfvlrkllle......kkkteleitqyqylaWpdhgvPe

SPVHVGHLFHHSLAART--RGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtpqsfdA-DPNiIDSVFRGLLGQRPGLVANQRQFDFCHRILE
|   . .| .    | .   ||.... . | ||.| . ..  . . ..             . . ..   |  ||. || ...|. |....| 
skapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee........edyiD.vagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPRB_pd Subfamily PTPRB 1-187 2.1e-09 31.9 In-house 113-284 (293) alignment 
Range on Protein: 1-187
Range on HMM: 113-284/293.0
MIWETNASVIVVLGDTDDK-----NNFWPEKedyqlhpavilgewYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSydDDVTEQLSLFHYSTWPQNGVPQ
|.||...|.||.| .. .|     ...||..              ... ||        ... .|     .. |.   .. ....  .|. .||. |||.
mvwekkssiivmltqlvekgkvkCeeYWPad..............eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPe

SPVHVGHL---FHHSL-AARTRGPLVIVSAHGGGRAGCYGVVSvayELLNMPDTpqsfdADPNIIDSVFRGLLGQRPGLVANQRQFDFCHRILEEC
..  . ..   .....  . ...|.|.  . | ||.| .  .    .||.  ..      |   | ..   |  .|  || ...|. | |. . . 
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfiald...rllqaiee.....edyvdifgivaelReeRnllvqtekqYifihqcvldl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-193 5.5e-09 30.0 In-house 110-285 (439) alignment 
Range on Protein: 1-193
Range on HMM: 110-285/439.0
MIWETNASVIVVLGDTDDKNNFWPEKEDyqlhpaVilgeWYTDsLYVRTDKVHPNTSGVEGLFEVsmvIHSYDDDVTEQ-LSLFHYSTWPQNGVPQSPVH
...| ... ||.| .  .  ..|| ...      |     | | . ||.|.       |   | |   .   |    |. .  ||| .||.. ||    |
lviekktvtivmltnlvesykywpsdae......v....cygd.iavrvdrnielpnyvirgfkv...fnerdttekertvlqfhyiawpdknvpaqash

VGHLFH---HSLAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTpqsFDadpniIDSVFRGLLGQRPGLVANQRQFDFCHR-ILEECLWGVAS
| ....    .   .  ||.|.  . | ||.|    . .| | |.. .     |     |. . . |  ||  .| .  |. | .  .||.  .|  .
vldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenk...vd.....ikgivkvlrkqrkqmvqalcqyvfiynavledivyGdia
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 55-186 1.8e-08 28.8 In-house 148-269 (288) alignment 
Range on Protein: 55-186
Range on HMM: 148-269/288.0
NTSGVEGLFEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHVGHLFHHSlaARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQsfdadpn
. .... | .||..  |   . .  .   |.  |...|||.. .   .| .      .. |.|. | .| ||.|   .. .| | | ..|          
kradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqkPivvhssaGvGrtgtlililialeslrlddflg.......

iIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
 | |..  |  .|   .  . |. . ||.. |
.irsllaklreerfkaiqtemqylyvhrcvle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 82-184 2.6e-08 27.6 In-house 185-281 (302) alignment 
Range on Protein: 82-184
Range on HMM: 185-281/302.0
LFHYSTWPQNGVPQSPVHVGHLFHHS--LAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtpqsfDADPNIIDsVFRGLLGQRPGLVANQRQFDF
. . . |.|. ||..  .. .  ..   . . .  ..|||| .| ||||   .. || | |.        ...||| . . . .  |||  | .  |. .
vyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqk.......gkepnike.ivksiRsqRpravdslkQyvs

CHRIL
 ...|
lyial
0036282 (Phosphotyrosine protein) phosphatases II 1-181 3e-08 29.1 In-house 31-163 (174) alignment 
Range on Protein: 1-181
Range on HMM: 31-163/174.0
MIWETNASVIVVLGDTDDKN-----NFWPEkedyqlhpavilgewytdslyvrtdkvhpntsgveglfevsmvihsYDDDVTEQLSLFHYSTWPQNGVPQ
|..| . ...| | .   ..     |.|||                                              . .| ..    ..|  || .||| 
mlkelgittvvmlleekelglykcinywpe..............................................lredlerlgiqylylpwpDhgvpd

SPVhVGHLFHHSLAARTR---GPLVIVSAHGGGRAGCYGVVSVAYELLNmpDTPQSFdadpniiDSVFRGLLGQRPGLVANQRQFDFCH
... . ...     |. .   ||...   .| ||.|.  .    . .|    ...          ...| |  |||| | .. |. |..
lsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvda.......ldlvrelRlqrpgmvqtpsQyrfly
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-187 3.3e-08 27.8 In-house 111-278 (315) alignment 
Range on Protein: 1-187
Range on HMM: 111-278/315.0
MIWETNASVIVVLGDTDDKNN-----FWPEKedyqlhpAVILGEWYtdslYVRTDKVHPNTSGVEGLfevSMVihsYDDDVTEqLSLFHYSTWPQNGVPQ
...| . . ||.| .. ....     .||.|        || |.        | .. . .   |  |   |.|   ..|.. | .  .||..||. |||.
lvfeedigkivmltnlvegekrkaekywpdk.......kviyGkit....vtrkseevnteytvrtl...svv...fgdnire.vvqlhytswpdmgvpk

SPVHVGHLFHHSLAART--RGPLVIVSAHGGGRAGCYGVVSVAYELLNMPDTPQSFdadpNiidsVFRGLLGQRPGLVANQRQFDFCHRILEEC
. . . .|. .    .|   |..|.    | ||.| .  ..   . ... .    .    |    . .|.  .| ..|.   |..| . .| | 
ytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvy....n....fitgvrqnrikmvqvaeqyqfiydallet
subfamily_PTPN3_pd Subfamily PTPN3 1-184 8.4e-08 26.5 In-house 103-272 (280) alignment 
Range on Protein: 1-184
Range on HMM: 103-272/280.0
MIWETNASVIVVLGDTDDKN-----NFWPEKEDYQlhpavilgeWYTdSLYVRTDKVHPNTSGVeglfEVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPQ
|.|| ..|.||.| .. ..      ..|||.|| .          |. .. |.  | . ..| |       .|..  . .   ..  . |  ||..|||.
mvweqksslivmlttlverGrvkChqyWPetedel.........eyg.efsvkcekedetksyv....lrelvlkdketkeerkilqlqylaWpdhgvPd

SPVHVGHLFHHSLAAR--TRGPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtpqsfdADPNIIDSVFRGLLGQRPGLVANQRQFDF-CHRIL
.. .. .. ..  ..|  .. |.|.  . | ||.| . .. .|  |...        |.|  .  . | .  ||  || .. |. | |. ||
dsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalaliea........aepvypldivrtmrdqramlvqtasqykfvCeail
0048076 (Phosphotyrosine protein) phosphatases II 32-185 2.3e-07 26.1 In-house 3-140 (145) alignment 
Range on Protein: 32-185
Range on HMM: 3-140/145.0
HPAVILGEWYTDSLYVRTDKVHPNTSGVEGLFEVsmviHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHVGHLFHHSLAARTRG-PLVIVSAHGGGRAGCY
 |. ||. .|  ||..  |  .    |.  .. .     |. ......   ..|  || .|||... .. ....   .|. .| | ..   .| ||.|..
wpseilpglylgslptaldlellkdlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtl

GVVSVAYEllnmpdtpqsF--DadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILE
 .  . ..          .  .     ...... .  |||| | |. |. |... ..
vaaylmll..........lgvs.....leealelvrsqrpgavpnpgqlrflyefel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1-184 2.6e-07 24.9 In-house 83-260 (270) alignment 
Range on Protein: 1-184
Range on HMM: 83-260/270.0
MIWETNASVIVVLGDTDDKN-----NFWPEkedyqlhpavilgeWYTDSLYVRTDKVHPNT---SGVEGLFEVSMVIHsyDDDVTEQLSLFHYSTWPQNG
||||.... ||.. .  .|.      .||.                 ... ... |..  .   .  ||     . ..  ..  ...|  |.| |||..|
miweekvtaivmttgleEkgrkkCerYWpa..............epkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhg

VPQSPV------HVGHLFHHS---LAARTR-GPLVIVSAHGGGRAGCYGVVSVAYELLNMpdtPQSFDADpNIIDSVFRgllgQRPGLVANQRQFDFCHR
||...       .. .....         . .||..  . | ||.|.  ..  | .||..    .. |   .||. . .    .|. ||   .|. | ..
vpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLee...tkkvdvl.aiieelRk....dRmalvqhpeqyeflyk

IL
 .
av
0041856 (Phosphotyrosine protein) phosphatases II 1-186 3.1e-07 25.6 In-house 53-169 (182) alignment 
Range on Protein: 1-186
Range on HMM: 53-169/182.0
MIWETNASVIVVLGdtddKNNFWPekedyqlhpavilgewytdslyvrtdkvhpntsgveglfevsmvihsydDDVTEQLSLFHYSTWPQNGVPQsPVHV
|..| . ..|| |       . ||                                                 .... .   ..|  || .|||  . ..
mlkelgittivnlt....eelywp.................................................ellerlgiqylylpwpDhgvpd.ldel

GHLFHHSLAarTRGPLVIVSAHGGGRAGCYGVVSVAYELlNMPdtpqsfdadpniIDSVFRGLLGQRPGLVANQRQFDFCHRILEE
 .. .  |.    || ..   .| ||.|.. .  . ..| ...            ...... .  .||| | .  |. |....| |
ldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.gvs............leeavklvrsrRpgmvitpnqyfflqlalle
0049772 (Phosphotyrosine protein) phosphatases II 1-187 4.3e-07 25.5 In-house 113-279 (314) alignment 
Range on Protein: 1-187
Range on HMM: 113-279/314.0
MI--WETNASVIVV---------------------LGDTDDKNNFWPEKEDYQLHpavilgewytdslyvrtdkvhpntsgveglfevsmvI-------H
|.  .. |  .||                      | . | ..|......  .|.                                             
mvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk....................................eelydpelf

sydddvTEQLSLFHYSTWPQNGVPqSPVHVGHLFHHSLAARTRGPLVIVSAHGGGRAGCYGVVSVAYELLNMpDTPQSFDAdpniidsvfrgLLGQRP--
      ...   ...  .| ...| .. .. ..... ..|.. ||...  ..| ||.|.. |.     ||.. .  . ..            .  .||  
......erlgikylripvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealed...........vrlkRpin

---GLVANQRQFDFCHRILEEC
   |.. ...|. |....|.| 
pnpgfieqleqyefilealley
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-189 1.2e-06 22.6 In-house 106-279 (315) alignment 
Range on Protein: 1-189
Range on HMM: 106-279/315.0
MIWETNASVIVVLGDTD--DK---NNFWPEKEDYqlhpAVILGewytdSLYVRTDKVHPNTSGVEglfeVSMVIHSYDDdvTEQLSLFHYSTWPQNGVPQ
|....... ||.. . .  ||   ...||...      .| .|     |. | . .....| ||       .|.   ..  ..... |..  ||..||..
mvlqekvttivmvtkkqegdkikcrqywPdrkad....svefG.....sikvellsleadtdgva....rklvtrksee..srtvtqfqftewPdkGvdk

SPVHVGHLFHHSLAA--RTRGPLVIVSAHGGGRAgcyGVVSVAYELLNMPDTPQSFDadpnIIDSVfRGLLGQRPGLVANQRQFDFCHRIL-EECLW
    . .| .   |   .   .|..  . | ||.   |||  . | ..     .| |    . . | . |  .|| ||  . .. | . .. |. ||
qtssllklikevkadngkkefsllvhcsaGvGrt...Gvvisidevvaqikrtrsvd....vfnfv.knlrakrpylvqteeeyafiydavledllw
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 77-184 1.2e-06 22.5 In-house 185-283 (305) alignment 
Range on Protein: 77-184
Range on HMM: 185-283/305.0
TEQLSLFHYSTWPQNGVPQSPVHVGHLFHHslAARTRGPLVIVSAHGGGRAGCygVVSVAYELLNMPdTPQSFDADPNIIDSVfrglLGQRPGLVANQRQ
... . .|.  ||. ||| . . .  |...  |  ..||.|.  . | ||.|   || . | | ..  . |  .    |.  .      ||   .  ..|
arkvthyhwidwpdrgvpaadlailellek..arpskgpivvhcsagigrtgs..vvmleyildqll.agqiiedtdkilqki....reqrnnsiqtdaq

FDFCHRIL
. | |...
ylfvhqvi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 64-184 1.7e-06 21.9 In-house 174-285 (305) alignment 
Range on Protein: 64-184
Range on HMM: 174-285/305.0
EVSMVIHSYDDDVTEQLSLFHYSTWPQNGVPqsPVHVGHLFHHSLAARTRGPLVIVSAHGGGRAGCygVVSVAYELLNMPDTPQSfDADPNIIdsvfRGL
.....  .|  | .  .  .... ||. |||  |...  |   |    .. |.|.  . | ||.|   .|.. | | .. .  .     |...    . |
qitllnltysgdqkmsvrhlqwtewpdrgvp..pckltslellsairgskvpivvhcsagigrtgt..ivaieyilekiaenkpc.ppmpelv....kal

LGQRPGLVANQRQFDFCHRIL
  ||   . |. |. | ||..
rdqrafsiqndvqylfihrvm
0046846 (Phosphotyrosine protein) phosphatases II 1-184 1.8e-06 23.3 In-house 42-169 (176) alignment 
Range on Protein: 1-184
Range on HMM: 42-169/176.0
MIWETNASVIVVLGDTDDK-----NNFWPEKEDYQLhpavilgewytdslyvrtdkvhpntsgveglfevsmvihsydddvteqlsLFHYSTWPQNGVPQ
|..| . ...| | .  ..      |.||| |....                                                   ...  || .|||.
mlkelgitavvnlteevelgrlkcpnywpeleklgi..................................................qylhlpwpDhgvpd

SpVHVGHLFHHSLAARTRG-PLVIVSAHGGGRAGCYGVvsvAYeLLNMpdtpqSFD--AdpniiDSVFRGLLGQRP-GLVANQRQFDFCHRIL
.  .. .|.     |...| | ..   .| ||.|.. .   || ||       ...  .     . ... .  ||| | | .. |  |... .
l.elllellefirealkeggpvlVHCsaGigRtgtlva...ay.llel.....ekglsv.....eealalvreqRplgavqtpeQyrflyefe
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1-138 2.5e-06 21.4 In-house 104-251 (301) alignment 
Range on Protein: 1-138
Range on HMM: 104-251/301.0
MIWETNASVIVVLGDTDDK-----NNFWPE--KEDYQLHPA-VILG-EWYTDSLYVRTDKVHPNTSGVEGLFEVSMVIHSYDddVTEQLSLFHYSTWPQN
.||.   . ||.. .....     ...||.  .|...  |  | |  |    .  .|  .|. . .  .| .| .. ..|     . ..  ..   |||.
liwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqd

GV---PQSPVHVGHLFHHSLAARTRGPLVIVSAHGGGRAGCYGVVSVAYE
||   |.  ..| .   |       ||.|.    . .|.| |  ||.. |
GvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglE
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 59-188 4e-06 20.4 In-house 69-194 (440) alignment 
Range on Protein: 59-188
Range on HMM: 69-194/440.0
VEGLFEVSMVIHSYDDDV-TEQLSLFHYSTWPQNGVPQSPVHVGHLFH---HSLAARTRGPLVIVSAHGGGRAGCygvVSVAYELLNMPDTPQSFDadpn
|.|. .   .  || . . .  |  .||  ||..|||.    | .. .   .|      |||.. .. | ||.|    . .   .|      .  |    
vkgvpdsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgv...iiavdsilreakrsdqid....

iIDSVFRGLLGQRPGLVANQRQFDFCHRILEECL
 | |.   .  .|| .|    |. | |  . | |
.ifsfinsmrnnrpqmvqtpeqyafvheavlegl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 73-188 5.9e-06 20.6 In-house 173-288 (325) alignment 
Range on Protein: 73-188
Range on HMM: 173-288/325.0
DDDVTEQLSLFHYSTWPQNGVPQSPVHVG------HLFHHSLAA--RTRGPLVIVSAHGGGRAGCYGVVSVAYEllNMpDTpqsfDADPNIIDSVFRgLL
..  |  .  |.. .|.. ||.. |  .       .  .  . |  .. .|...  . | ||.| .  .  | .  ..  .    ..  .| ..| . | 
kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysala..kv.ie....esrvdifgfvkk.lr

GQRPGLVANQRQFDFCHRILEECL
 .|| .|    |. ...  | | .
kdrpsmvetvdqyiliyealveay
0048179 (Phosphotyrosine protein) phosphatases II 36-182 6.7e-06 21.4 In-house 7-139 (144) alignment 
Range on Protein: 36-182
Range on HMM: 7-139/144.0
ILGEWYTDSLYVRTDKVHPNTSGVEGLFEVSMviHSYDDDVTEQLSLFHYSTWPQNGVPQSPVHVGHLFHHSLAA-RTRGPLVIVSAHGGGRAGCYGVVS
||. .|  ||..  |  .    |.  .. ..   . . .... .   ...  || .|||... .. ....   .| .  || ..   .| ||.|.. .  
ilpglylgslptaldlellkklgittvinlte..eyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

VAYellnmpdtpqSFDADpniIDSVFRGLLGQRPGLVANQRQFDFCHR
. .           .. .   ...... .  .||| | |. |. |...
lmk..........klgls...leealalvrsrrpgavpnpgqlrfLle