Gene AquePTP-sf1-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily AquePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP144_AA protein Get Run
AqueP144_AA_1000-1158 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1006-1171 6.4e-81 263.2 In-house 1-140 (169) alignment 
Range on Protein: 1006-1171
Range on HMM: 1-140/169.0
IHKRYNELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINAnfvgsplypksyiiaqwpmentiptfwRMIWETNASVIVV
|||.|||||||||.|||||||||||||||||||||||||||.||||||||||||||||||                           |||||||||||||
ihkgynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivv

LGDADDKNNFWPEKEDYQLHPAVILGEWYTDSLYVRTDKVTALCKG-EYPNGITVSILNTDNTVIKN
|||.||||||||||||||||||||||||||||||||||||.|...| |    ... | . |..| ..
lgdtddknnfwpekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvtek
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1007-1161 9.7e-79 256.0 In-house 1-129 (169) alignment 
Range on Protein: 1007-1161
Range on HMM: 1-129/169.0
HKRYNELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINAnfvgsplypksyiiaqwpmentiptfwRMIWETNASVIVVL
||.|||||||||.|||||||||||||||||||||||||||.||||||||||||||||||                           ||||||||||||||
hkgynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl

GDADDKNNFWPEKEDYQLHPAVILGEWYTDSLYVRTDKVTALCKG-EYPNGITVSI
||.||||||||||||||||||||||||||||||||||||.  . | |    ... |
GdtddknnfwpekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvi
0051299 (Phosphotyrosine protein) phosphatases II 1005-1126 1.2e-29 99.1 In-house 24-147 (288) alignment 
Range on Protein: 1005-1126
Range on HMM: 24-147/288.0
FIHKRYNELKEFMKMieYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIV
.... ..|| ..  .  ..   | | .| .|||    |.  | ||||. . .. |||||||...  . ... .|..|.|..||.  ||||.|| | .|||
glleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIv

VLGDADDKN-----NFWPEkEDYQLHP
.| . ....      .||. .... . 
mltklvelgrekcaqYwpl.ggsltyg
0046845 (Phosphotyrosine protein) phosphatases II 1006-1125 3.7e-29 97.4 In-house 2-132 (284) alignment 
Range on Protein: 1006-1125
Range on HMM: 2-132/284.0
IHKRYNELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMED-LGSDYINANFVGSP-----LYPKSYIIAQWPMENTIPTFWRMIWETN
... . ||  .  .....   | | .| .|||    |.  | ||||... .|  .||||||..|  .      ..| .|..|.|..||.  ||||.|| |
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

ASVIVVLGDADDKNN-----FWPEKEDYQLH
..|||.| . .....     .||...... .
vrvIVmltelvengrekcaqYwplegevlty
0040438 (Phosphotyrosine protein) phosphatases II 1004-1125 1.3e-28 95.6 In-house 16-140 (317) alignment 
Range on Protein: 1004-1125
Range on HMM: 16-140/317.0
GFiHKRYNELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVI
.| .. ..| ....... ..  .||| .|  |||    |   | ||||. . .||.||||||..|  | ... .|..| |..||.  ||||.|| . .||
df.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

VVLGDADDKN-----NFWPEkEDYQLH
| | . ....      .||. .... .
vmLteleelgrekcaqYwpl.getlty
0050432 (Phosphotyrosine protein) phosphatases II 1005-1121 2.6e-28 94.7 In-house 43-159 (308) alignment 
Range on Protein: 1005-1121
Range on HMM: 43-159/308.0
FIHKRYNELKEFMKmiEYNNFMAELTCNETKNRPAGPLAPSHMRVKLqrvmeDLGSDYINANFVGSP--LYPKSYIIAQWPMENTIPTFWRMIWETNASV
.... ..|| ..     .. . |.| .| .|||    |.  | ||||     | |||||||..|  .   .|. .|..|.|..||.  ||||.|| | .|
lleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVVLGDADDK-----NNFWPEKED
||.| . ...       .||....
IvmLtklvengrekcaqYwplelg
0047943 (Phosphotyrosine protein) phosphatases II 1005-1122 7.8e-28 93.1 In-house 13-129 (273) alignment 
Range on Protein: 1005-1122
Range on HMM: 13-129/273.0
FIHKRYNELKEFMKmiEYNNFMAELTCNETKNRPAGPLAPSHMRVKLqrvmEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIV
.... ...|... .  ...   |.| .| .|||    |.  | ||||    .| |||||||..|  . ... .|..|.|..||.  ||||.|| |..|||
llleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

VLGDADDKNN-----FWPEKEDY
.| . .....     .||.... 
mLtelvelgrekcaqYwplegge
0043336 (Phosphotyrosine protein) phosphatases II 1007-1125 7.9e-28 93.1 In-house 20-141 (278) alignment 
Range on Protein: 1007-1125
Range on HMM: 20-141/278.0
HKRYNELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVL
.. ..| .|....  ..  .|.| .| .|||    |.  | ||||. . .||.||||||..|  . .|. .|..|.|...|.  ||||.|| . ..||.|
tllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmL

GDADDKN-----NFWPekEDYQLH
 . ....      .||  .... .
telvelgrvkcaqYwp..ggslty
0039614 (Phosphotyrosine protein) phosphatases II 1007-1129 3.8e-27 91.0 In-house 32-158 (297) alignment 
Range on Protein: 1007-1129
Range on HMM: 32-158/297.0
HKRYNELKEFMKMIEyNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVME-DLGSDYINANFVGSPLY-PKSYIIAQWPMENTIPTFWRMIWETNASVIV
.. ..| .| ..... .   |.| .| .|||    |.  | ||||. ... ||.||||||..|  . . .. .|..|.|...|.  ||||.|| . .|||
tllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtviv

VLGDADDKN----NFWPEKEDyQLHPAVI
 | . ....     .|||... . .. ..
mLtklvelgrkcaqywpeegg.tygdftv
subfamily_PTPRD_pd Subfamily PTPRD 1011-1121 4.7e-27 89.8 In-house 27-142 (564) alignment 
Range on Protein: 1011-1121
Range on HMM: 27-142/564.0
NELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDAD
.| |.. .  . .   |.  .|  ||| |  .|  | ||.|..|  | |||||||.|. .   .|.|| .| |...||  ||||.|| | |.|| |    
eeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkle

DKNN-----FWPEKED
.|..     .||||. 
EkgkvkchkYWPekgt
0036941 (Phosphotyrosine protein) phosphatases II 1012-1122 5e-27 90.4 In-house 21-131 (297) alignment 
Range on Protein: 1012-1122
Range on HMM: 21-131/297.0
ELKEFMKmiEYNNFMAELTCNETKNRPAGPLAPSHMRVKLqrvmEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADD
|| ....   ..   |.| .| .|||    |.  | ||||    .| |||||||..|  . ... .|..|.|..||.  ||||.|| | .|||.| . ..
ellplll..lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelve

KNN-----FWPEK-EDY
..      .||.. ...
lgrekcaqywpleeges
0045450 (Phosphotyrosine protein) phosphatases II 995-1123 5.3e-27 90.8 In-house 18-160 (307) alignment 
Range on Protein: 995-1123
Range on HMM: 18-160/307.0
QRSGVLKMGGFIHKRYNELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMED-LGSDYINANFV--------GSPLYPKSYIIAQWPME
..  .|.    ..| ...|... ... ..  .|.| .| .|||    |.  | ||||. . ..  .||||||..|        ...  .. .|..|.|..
vllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlp

NTIPTFWRMIWETNASVIVVLGDADDKNN-----FWPEKEDYQ
.|.  ||||.|| . .||| | . .....     .||......
etvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeel
DSPc_SM00195 1020-1126 4.1e-26 87.2 In-house 16-126 (263) alignment 
Range on Protein: 1020-1126
Range on HMM: 16-126/263.0
IeyNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDK-----NN
   .   ||   |..|||    |   | ||||..  .. ||||||||..  . ..|.||..|.|...|.  ||||.||.. ..||.| . ...     ..
k..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

FWPEKE-DYQLHP
.|||.. ... . 
ywpeesggketfg
PTPc_SM00194 1020-1126 4.1e-26 87.2 In-house 16-126 (263) alignment 
Range on Protein: 1020-1126
Range on HMM: 16-126/263.0
IeyNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDK-----NN
   .   ||   |..|||    |   | ||||..  .. ||||||||..  . ..|.||..|.|...|.  ||||.||.. ..||.| . ...     ..
k..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

FWPEKE-DYQLHP
.|||.. ... . 
ywpeesggketfg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1010-1122 1.7e-24 81.4 In-house 26-141 (318) alignment 
Range on Protein: 1010-1122
Range on HMM: 26-141/318.0
YNELKEFMKmiEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDA
|..|.   .  .  .. .   .|..||| |  ||  | ||||| . .. ||||||||..      |.|| || |. .||. ||||.|| |..|||.| . 
yerlsrsee..tvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqe

DDK-----NNFWPEKEDY
 ..     ...||.|.  
eergkakvhryWPskgsr
subfamily_PTPRG_pd Subfamily PTPRG 1007-1122 3.2e-24 80.1 In-house 22-143 (563) alignment 
Range on Protein: 1007-1122
Range on HMM: 22-143/563.0
HKRYNELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGS-DYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVV
.. ...|.. ..  . .  ... ..|  |||    .|  . ||||. . .  .. ||||||..      | .|..| |...|.  ||||||| |...||.
seefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivm

LGD-----ADDKNNFWPEKEDY
. .     . . . .||. |  
itnlvergrrkcdvYWPkdese
subfamily_PTPRB_pd Subfamily PTPRB 1007-1125 7.9e-24 79.2 In-house 28-149 (293) alignment 
Range on Protein: 1007-1125
Range on HMM: 28-149/293.0
HKRYNELKEFMKMIeyNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVL
 ..|.|||.. |    .  .|||..|..|||    |.  | ||||. . .. ||||||||..     |. .| .| |. .|.  ||||.||...|.||.|
seeyeelkavgkdq..avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivml

GDADDK-----NNFWPEKEDYQLH
 .  .|     ...||..|. .|.
tqlvekgkvkCeeYWPadeepvly
subfamily_Ptp69D_pd Subfamily Ptp69D 1008-1121 8.5e-24 79.2 In-house 26-142 (307) alignment 
Range on Protein: 1008-1121
Range on HMM: 26-142/307.0
KRYNELKEFmkMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLG
| |..|..   .|. .  ..|   |  |||     |  . ||||...  .  ||||||.|. .    |..|.|| |.|.||  |||||.| .  .||.| 
keyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmls

DADDKNN-----FWPEKED
. ..||.     .||. . 
nlteknrkkcakYWpiede
0040439 (Phosphotyrosine protein) phosphatases II 1025-1125 1.9e-23 78.8 In-house 4-108 (249) alignment 
Range on Protein: 1025-1125
Range on HMM: 4-108/249.0
FMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN-----NFWPEk
 .|.| .|  |||    |.. | ||||. . .  .||||||...  . ... .|..|.|...|.. ||||.|| . .||| | . . ..      .||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

EDYQLH
.... .
ggsley
0042113 (Phosphotyrosine protein) phosphatases II 1027-1126 1.9e-23 78.6 In-house 4-107 (245) alignment 
Range on Protein: 1027-1126
Range on HMM: 4-107/245.0
AELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN-----NFWPEkED
|.| .| .|||   .|.  | ||||. . .||.||||||..|. . ... .|..|.|...|.. ||||.|| . ..|| | . ....      .||. ..
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

YQLHP
.. . 
sltyg
0045098 (Phosphotyrosine protein) phosphatases II 1026-1126 1.1e-22 76.1 In-house 27-119 (278) alignment 
Range on Protein: 1026-1126
Range on HMM: 27-119/278.0
MAELTCNETKNRPAGPLAPSHMRVKlqrvmedlgsDYINANFVGSPlyPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN-----NFWPEkE
 | . .|  |||    |.  | |||          |||||... ..  || .|..|.|...|.  ||||.|| . .||| | .  ...      .||| .
palylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.g

DYQLHP
... . 
gsltyg
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1026-1122 1.2e-22 75.7 In-house 55-150 (319) alignment 
Range on Protein: 1026-1122
Range on HMM: 55-150/319.0
MAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGdADDKNNFWPEKEDY
 |.|  |  |||    ||  . .|||.|.    .|||||| ||     .. || || |..||.  ||||||| |.| ||.|   |   ..|| | . 
fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.kdkcsqywplkivi
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1026-1122 1.4e-22 75.5 In-house 19-114 (284) alignment 
Range on Protein: 1026-1122
Range on HMM: 19-114/284.0
MAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGdADDKNNFWPEKEDY
 |.|  |  |||    ||  . .|||.|..   .|||||| |.     .. || .| |..||.  ||||||| |.| ||.|   |   ..|| | . 
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.kdkcsqywplkivi
Y_phosphatase Protein-tyrosine phosphatase 1032-1121 3e-22 74.6 Pfam-A 1-93 (235) alignment 
Range on Protein: 1032-1121
Range on HMM: 1-93/235.0
NETKNRPAGPLAPSHMRVKLqrvM-EDLGSDYINANFV-GSPlYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDK-----NNFWPEKED
|..|||    |.  . ||||     ..  |||||||.| | .  .|..|..| |...||  ||||.|. . .|||.| . ..|     ...|||.|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeee
Y_phosphatase Protein-tyrosine phosphatase 1032-1121 3e-22 74.6 In-house 1-93 (235) alignment 
Range on Protein: 1032-1121
Range on HMM: 1-93/235.0
NETKNRPAGPLAPSHMRVKLqrvM-EDLGSDYINANFV-GSPlYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDK-----NNFWPEKED
|..|||    |.  . ||||     ..  |||||||.| | .  .|..|..| |...||  ||||.|. . .|||.| . ..|     ...|||.|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeee
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1007-1122 4.3e-22 73.7 In-house 30-153 (298) alignment 
Range on Protein: 1007-1122
Range on HMM: 30-153/298.0
HKRYNELKEFMKMIE-YNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVV
.. ...|..  . ||  .  .|. . |. ||| |  .|  . || |... .|  |||||| |. .    ...|..| |...|.  ||||..| ....||.
alefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVm

LGDADDK-----NNFWPE--KEDY
| .  ..     ...||.  || |
ltnleeldktkyhkywPdegkety
subfamily_CG7180_pd Subfamily CG7180 1031-1126 2.8e-21 70.4 In-house 41-140 (296) alignment 
Range on Protein: 1031-1126
Range on HMM: 41-140/296.0
CNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKNN----FWPEKEDYQLHP
 |  |||    . . . || |...  .  |||||| .| | | .| ||. ..|...|.  |||.... ..| .||| .  | ..    .||.|   |  .
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqyge
subfamily_PTPRK_pd Subfamily PTPRK 1026-1122 1.3e-20 68.5 In-house 37-138 (314) alignment 
Range on Protein: 1026-1122
Range on HMM: 37-138/314.0
MAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN-----NFWPEKE
 |    |..|||    ||. ..||.|. . .|  ||||||... |   |. .|..| |...|.  |||.... |.. ||.| .  ..      ..|||. 
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

DY
. 
ev
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1007-1128 1.8e-20 68.2 In-house 24-148 (288) alignment 
Range on Protein: 1007-1128
Range on HMM: 24-148/288.0
HKRYNELKEFMKMIeyNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVL
.. || | .. |    .. ...|. |..|||    |.  . ||||. . |  |.|||||... .    | || .| |. .|.  ||....|...| || |
seeynsLaalektk..svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml

GDA-----DDKNNFWPEKEDYQLHPAV
 .         ...||.... ...  |
telveggktkCeeYWPdadkpknyGsv
subfamily_PTPN9_pd Subfamily PTPN9 1006-1111 8.4e-20 66.0 In-house 18-121 (297) alignment 
Range on Protein: 1006-1111
Range on HMM: 18-121/297.0
IHKRYNELKEFMkmIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVV
..| | |...    .| .  ...| .| .||| .  |   . ||.|..| ||  |||||||||     .|..| .| |...|.  ||||.|| .. |||.
lskeyaeirnep..veGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivm

LGDADD
     .
ttrvve
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1007-1112 9.2e-20 65.9 In-house 26-128 (319) alignment 
Range on Protein: 1007-1112
Range on HMM: 26-128/319.0
HKRYNELKEFMKMieyNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVL
.| ...|||  ..   .   |.   |..|||    ||  . ||.|. . .  |||||||.|. .    . .| .| |.||||  ||||.|| ..|..|.|
ekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvml

GDADDK
 .  .|
tklvek
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1008-1120 1.6e-19 64.8 In-house 14-130 (287) alignment 
Range on Protein: 1008-1120
Range on HMM: 14-130/287.0
KRYNELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRvMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVL-
| .. |||  .   .    || . .  ||| |  |   . || |     .|||||||||.| |    ...| || |.  |.  |||...||........ 
kevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmt

---GDADDK-NNFWPEKE
    .|  |  ..|||.|
reveearlkcykywPere
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1027-1120 7.5e-19 62.9 In-house 36-134 (281) alignment 
Range on Protein: 1027-1120
Range on HMM: 36-134/281.0
AELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN-----NFWPEKE
..   | .|||     |  . |||...  |.  .|||||||| .   .| ||..| |. ... .||.|.||...|.||..    ...      .||...
skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1027-1117 8.1e-19 62.8 In-house 4-98 (250) alignment 
Range on Protein: 1027-1117
Range on HMM: 4-98/250.0
AELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN----NFWP
|.   |. ||| |  .|  . || |...  |  |||||| |. .    |..|..| |...||  ||||..| ....||.| .  ...    ..||
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywP
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1013-1123 9.3e-19 62.7 In-house 28-142 (305) alignment 
Range on Protein: 1013-1123
Range on HMM: 28-142/305.0
LKEFMKMiEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLG-----
 |....  |  ... . . |..||| . .    . |..|.   ..  ||||||..| .    |.||.|| |..||.  |||.|.|.  |.|| |      
ykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveg

DADDKNNFWPEKEDYQ
. |  . .|||.. ..
gkdkCrqYWpesktek
subfamily_ptpA1_pd Subfamily ptpA1 1029-1112 1.6e-18 61.6 In-house 44-126 (418) alignment 
Range on Protein: 1029-1112
Range on HMM: 44-126/418.0
LTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSpLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDK
   | .||| .  |   | ||.|... .  ||||||||..    ||| .| .| |. |||  ||||.||  . .||.|    ..
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresen
0037934 (Phosphotyrosine protein) phosphatases II 1026-1158 2.1e-18 62.2 In-house 4-137 (243) alignment 
Range on Protein: 1026-1158
Range on HMM: 4-137/243.0
MAELTCNETKNRPAGPLAPSHMRVKLqrvmEDlgSDYINANFVGSPlyPKsYIIAQWPMENTIPT----FWRMIWETNASVIVVLGDADDK-----NNFW
.| | .| .|||  . |.  | ||||    |.  |||||||..  .  |. .|. |.|...|.      ||||.|| . .||| | . ...       .|
iallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PEKEDYQLHPAVILGEWYTDSLYVRTDKVTALC-KGEYPNGIT
|... |      .|.| ..|.  ||| ... |  .... ..| 
pgevtygdftvtllseehlddytvrtlllenldlddltrlvih
subfamily_PTPN12_pd Subfamily PTPN12 1020-1123 2.6e-18 60.9 In-house 28-136 (290) alignment 
Range on Protein: 1020-1123
Range on HMM: 28-136/290.0
IEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDK-----NN
 .|.. ..| . | .|||    |   . ||.|..  |. |||||||||.  .  ...|| || |. .|.  |||||||.| ...|..    .      . 
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

FWPEKEDYQ
.|||. . .
YWpeegeee
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1014-1125 2.9e-18 60.9 In-house 9-128 (274) alignment 
Range on Protein: 1014-1125
Range on HMM: 9-128/274.0
KEFMKMIE-YNNFMAELTCNETKNRPAGPLAPSHMRVKLQR-VMEDLGSDYINANFVGSP-LYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDAD
|||...   ...   ... ..||||    |  .. || |..   ||  |.|||||..  .    | |. .| |. ||.  |||||......|||.| .  
keflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklk

DKNN-----FWPEKEDYQLH
..|.     ..|..|||...
eaneqkCavyfPdaedyeis
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 987-1119 8.7e-18 59.5 In-house 6-140 (297) alignment 
Range on Protein: 987-1119
Range on HMM: 6-140/297.0
EQWVISLKQRSGVLKMGGFIHKRYNELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYpkSYIIAQWPMEN
|.  | | . . ... .   .  ..|..   .   ... .||   |  |.| .  |     ||||. | .|  |||.|| || .  .   .|  | ||..
errpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TIPTFWRMIWETNASVIVVLGDADDKNN----FWPEK
|.  ||.|... ..|.||.| | .....    .|..|
tvadfWamvldeqvstivmlnddnerdkkcaryWsdk
subfamily_PTPN6_pd Subfamily PTPN6 988-1123 1.3e-17 58.7 In-house 11-151 (306) alignment 
Range on Protein: 988-1123
Range on HMM: 11-151/306.0
QWVISLKQRSGVLKMGGFiHKRYNELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQrVMEDLGSDYINANFVG--SPLYPKSYIIAQWPME
| |  |.. .  |.  || .. ..||..  ..  ..   .. . |..|||    |   | ||.|.   .  ||||||||..   ..   |||| .|  .|
qrvselekeeeslekagf.eeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgcle

NTIPTFWRMIWETNASVIVVLGDADDK-----NNFWPEKEDYQ
.|.. ||||.|. |. |||..    ..       .||..|. .
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeeke
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1029-1120 1.3e-17 58.8 In-house 46-142 (315) alignment 
Range on Protein: 1029-1120
Range on HMM: 46-142/315.0
LTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN-----NFWPEKE
 . |  |||    .|  . ||.|  .  | .|||.||||.    ... || || |  ...  |||...| . . ||.| .  ...     ..||.|.
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1031-1121 9.4e-17 55.9 In-house 46-137 (287) alignment 
Range on Protein: 1031-1121
Range on HMM: 46-137/287.0
CNETKNRPAGPLAPSHMRVKLQrvmeDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN-----NFWPEKED
 |. ||| .  | |   || |.    .   ||||| |. .    | .|||. || ||.  ||..|.. | ..||.| .  ...     ..|||.. 
qnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks
subfamily_PTPN23_pd Subfamily PTPN23 1003-1122 2e-16 54.6 In-house 14-135 (288) alignment 
Range on Protein: 1003-1122
Range on HMM: 14-135/288.0
GGFIHKRYNELKEFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQrvmeDLGSDYINANFVGS--PLYPkSYIIAQWPMENTIPTFWRMIWETNA
 . ..|...||..  .    .. .|   .. .|||    |   | ||||.    .   ||||| || .  |  | ..|..| |...|.  ||.|..|  .
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqks

SVIVVLGDADDKN-----NFWPEKEDY
||||.| . ....     ..|||... 
sviVmllskeelgkpkvdrYwPedkge
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1026-1119 2.2e-16 54.6 In-house 14-113 (270) alignment 
Range on Protein: 1026-1119
Range on HMM: 14-113/270.0
MAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVG-SPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN-----NFWPEK
. | . ... || |. |   . ||.|... ||  . |||||.|      .|.|| |. |...|.  |||||||.... ||.. .  .|.      .||..
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae
subfamily_PTPN1_pd Subfamily PTPN1 1018-1132 3.2e-16 53.9 In-house 20-130 (290) alignment 
Range on Protein: 1018-1132
Range on HMM: 20-130/290.0
KmiEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEdlgsDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN----
.  ...   |.|  | ..||        | |.||.|       |||||..|  .   .|||..| |. ||.  ||.|.|| ..  .|.|    .|.    
s..dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

-NFWPEKEDyqlHPAVILGE
 ..||..|.   . ...| .
aqywPqgee...ekellled
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1022-1120 1.1e-15 52.3 In-house 34-137 (315) alignment 
Range on Protein: 1022-1120
Range on HMM: 34-137/315.0
YNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDAD--DK---NNFW
|..  |  | | .|||    |   . ||||. . ..  |||||| .. |    |.|| .| | . ..  ||||....... ||.. . .  ||   ...|
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PEKE
|...
Pdrk
subfamily_PTPRA_pd Subfamily PTPRA 1026-1114 1.1e-15 52.3 In-house 52-140 (330) alignment 
Range on Protein: 1026-1114
Range on HMM: 52-140/330.0
MAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKNN
.|.   |. |||    |   . || |. .     |||||| |.      ...| || | |.|.  ||||||| ... ||.| . .....
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerke
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1026-1127 1.5e-15 51.8 In-house 40-148 (290) alignment 
Range on Protein: 1026-1127
Range on HMM: 40-148/290.0
MAELTCNETKNRPAGPLAPSHMRVKLQRVME--DLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKNN-----FWPE
..  . |...|| |  . .   |. |... .  |   .|||| ..      |.||..| |..||.  ||..||. . ..||.| .  ....     .||.
vgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpd

KEDYQLHPA
..  .. . 
sdtkaygef
0049772 (Phosphotyrosine protein) phosphatases II 1020-1140 2.7e-15 52.4 In-house 34-177 (314) alignment 
Range on Protein: 1020-1140
Range on HMM: 34-177/314.0
IEYNNFMAELTCNETKNRPAGPLAPShMRVKLqRVMEDLGSDYINANFVGSPlypKSYIIAQWPMENTIPTF----------WRMI--WETNASVIVV--
 |.   .| | .| .|||    |     ||.|   ..  |||||||..| ..   ...|..|.|.|.|.  |          |||.  .. |  .||   
peltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsr

-------------------LGDADDKNNFWPEKEDYQLHpavilGEWYTDSLYV
                   | ..| ..|......  .|.     .| | ..|. 
devladelsrLdaAlgKtpllildgngneptaadlellk.....eelydpelfe
subfamily_PTPN14_pd Subfamily PTPN14 1010-1121 2.8e-15 51.1 In-house 26-144 (300) alignment 
Range on Protein: 1010-1121
Range on HMM: 26-144/300.0
YNELKEFMKMIEYNN-FMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDlGSDYINANFVGSPLY--PKSYIIAQWPMENTIPTFWRMIWETNASVIVVL
. |  . .|. |  .   |.|  |. |||    |   ..||.|.   |.  ..||||  .  ..    .|||.|| |.|.|.  ||.|.||.. ..|| |
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

GDADD-----KNNFWPEKED
 .  .       ...|..|.
teeeedgkeksfkyfPkles
subfamily_PTPRN_pd Subfamily PTPRN 1006-1120 5.3e-15 49.9 In-house 31-150 (297) alignment 
Range on Protein: 1006-1120
Range on HMM: 31-150/297.0
IHKRYNELKEFMKMiEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSP-LYPKSYIIAQWPMENTIPTFWRMIWETNASVIV
..|... |...    .  . .|.   | .||| .  |.  | ||||..  ..  |||||| ..        .|| .| |. .|.  ||.|.||  . |||
lekewealcayeae.pstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvviv

VLGDADD-----KNNFWPEKE
 |   ..      ...||.. 
nltrleeegvkqckrywpdeG
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1022-1119 1.5e-14 48.0 In-house 33-135 (515) alignment 
Range on Protein: 1022-1119
Range on HMM: 33-135/515.0
YNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDA--DDKN---NFW
| . .|.   | .|||    |     ||||. . ..  |||.|| .. |    |.|| .| | . ..  |||.... | . |... .   .||    ..|
ypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyW

PEK
|.|
Pdk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1027-1119 1.8e-14 48.6 In-house 43-139 (325) alignment 
Range on Protein: 1027-1119
Range on HMM: 43-139/325.0
AELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDK----NNFWPEK
| .  |  |||    .|  . || |.   .|  ||||||... .    . .. || |. .||  .||.. . ..||.|||   | .      .||..
amkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpke
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1031-1122 1.9e-14 48.0 In-house 47-138 (439) alignment 
Range on Protein: 1031-1122
Range on HMM: 47-138/439.0
CNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKNNFWPEKEDY
 ..||||     |  | || || .     | |||||..     .| || .| | ..|  .|||...| ... ||.| .  .  ..|| ... 
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesykywpsdaev
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1031-1122 2e-14 47.8 In-house 95-184 (244) alignment 
Range on Protein: 1031-1122
Range on HMM: 95-184/244.0
CNETKNRPAGPLAPSHMRVKLQRvmEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKNNFWPEKEDY
 |  ||| .  |     || | .    .|  |||| |||       ||..| |. .|   ||.|. |    |.||||  ......||. |  
nnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpdsepl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1027-1123 1.1e-13 45.7 In-house 28-129 (297) alignment 
Range on Protein: 1027-1123
Range on HMM: 28-129/297.0
AELTCNETKNRPAGPLAPSHMRVKLQRVMEdlGSDYINANFVGSPLYPK--SYIIAQWPMENTIPTFWRMIWETNASVIVVLGDAD----DK-NNFWPEK
|       |||    ||    ||||.||.   ..|||||..|  |  ..   ||.|| |...|.  ||....| .  |||..        ||   .||. 
akrnsslrknryrdilatddtrvkllrvit..erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

EDYQ
.. .
vqer
subfamily_PTPN3_pd Subfamily PTPN3 1009-1122 2.7e-13 44.5 In-house 20-136 (280) alignment 
Range on Protein: 1009-1122
Range on HMM: 20-136/280.0
RYNELkeFMKMIEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEdlgsDYINANFVGSPLY----PKSYIIAQWPMENTIPTFWRMIWETNASVIV
....|  . |  . .  .| .. | .|||    |.  . ||||.        ||||||.|   .      . ||..| |...|   ||.|.|| ..|.||
qfeql..yrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

VLGDADDK-----NNFWPEKEDY
.| .  ..      ..|||.|| 
mlttlverGrvkChqyWPetede
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1020-1113 4.4e-13 43.4 In-house 33-126 (392) alignment 
Range on Protein: 1020-1113
Range on HMM: 33-126/392.0
IEYNNFMAELTCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN
  |.. .|.   |  |||    |     ||||. . .   |||.|| .. |    |.|| .| |   ..  ||||... |.. |... . .. .
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd
subfamily_egg_pd Subfamily egg 1033-1121 1.3e-12 42.0 In-house 41-132 (307) alignment 
Range on Protein: 1033-1121
Range on HMM: 41-132/307.0
ETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFV-GSPLYpKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN---NFWPEKED
 .| |          ||||.        |.| || | | ||.   .|.|| |. ||   ||||... .   ||.|  . . .    .||  |.
lekarskrvhckdssrvklelrrGqylddfihanrvkGkpll.nefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaes
0041856 (Phosphotyrosine protein) phosphatases II 1035-1122 1.4e-12 43.0 In-house 4-77 (182) alignment 
Range on Protein: 1035-1122
Range on HMM: 4-77/182.0
KNRPAGPLAPSHMRvklqrvmedlGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGdaddKNNFWPEKEDY
|||    | . | |          ..||||||.. ..|... .|..|.|. .|.. |.||..| . ..|| |       . |||..  
knrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywpeller
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1032-1111 1.9e-12 41.4 In-house 37-117 (281) alignment 
Range on Protein: 1032-1111
Range on HMM: 37-117/281.0
NETKNRPAGPLAPSHMRVKLQRVME-DLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADD
|. ||| .   .    ||.|.  |     .||| ||.. ||.  . ||..| | ..|   ||||||. |.. ||.| .  .
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1032-1117 2.9e-12 41.3 In-house 3-92 (237) alignment 
Range on Protein: 1032-1117
Range on HMM: 3-92/237.0
NETKNRPAGPLAPSHMRVKLQRVMEDlgSDYINANFVG-SPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKNN-----FWP
|. ||| .   |  | || |.    .  ||||||...      ||.|| || |.|..   ||.|.|. . ||||.|    ..|.     .||
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1033-1121 4.8e-12 40.2 In-house 43-136 (301) alignment 
Range on Protein: 1033-1121
Range on HMM: 43-136/301.0
ETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDK-----NNFWPEKED
 ....   ..   .. .| .. ..    .||||... .    | .|.|| ||..|.  |||.||.   . ||.. . ...     ...||. | 
lnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnsea
subfamily_CG42327_pd Subfamily CG42327 1033-1121 7.1e-12 39.6 In-house 29-123 (319) alignment 
Range on Protein: 1033-1121
Range on HMM: 29-123/319.0
ETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGSP-LYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN-----NFWPEKED
. |.| .  .   . || |||. .|  . |..|..|  .   | ||| || ..|..   |||..|| .. ||| | |  ..      ...| || 
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1027-1123 1.1e-11 39.1 In-house 28-130 (283) alignment 
Range on Protein: 1027-1123
Range on HMM: 28-130/283.0
AELTCNETKNRPAGPLAPSHMRVKLQRVMEdlgsDYINANFVG---SPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDK-----NNFWPE
|    |..|||    ..    ||.|.   .    ||||| |.    |    | ||||| |...|.  ||.|... ... ||.|    .        .||.
asadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk

K--EDYQ
.  ||| 
rGsedyG
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1051-1123 1.7e-11 38.5 In-house 7-76 (130) alignment 
Range on Protein: 1051-1123
Range on HMM: 7-76/130.0
LQRVMedlGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKNNFWPEKEDYQ
..|.    | .||||.|||     . |. .| |. .|   ||.|. |    |.||||  ......||. | ..
vsrlq...gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1030-1108 1.9e-11 38.6 In-house 6-85 (239) alignment 
Range on Protein: 1030-1108
Range on HMM: 6-85/239.0
TCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGS-PLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGD
  |..||| |  ..  | || |... .|  ||||||...      ||.|| .|  .| .   ||||.|.    |||.|  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltg
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1030-1108 1.9e-11 38.6 In-house 5-84 (239) alignment 
Range on Protein: 1030-1108
Range on HMM: 5-84/239.0
TCNETKNRPAGPLAPSHMRVKLQRVMEDLGSDYINANFVGS-PLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGD
  |..||| |  ..  | || |... .|  ||||||...      ||.|| .|  .| .   ||||.|.    |||.|  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltg
subfamily_PTPN13_pd Subfamily PTPN13 1010-1119 2.3e-11 38.5 In-house 17-126 (273) alignment 
Range on Protein: 1010-1119
Range on HMM: 17-126/273.0
YNELKEfMKMIEyNNFMAELTCNETKNRPAGPLAPSHMRVKLQrvmeDLGSdYINANFVGSPLYPK--SYIIAQWPMENTIPTFWRMIWETNASVIVVLG
..||.| .| .. .  ...   |..|||    |   . ||||.    | |. ||||...  |.  .  .||..| |. .|.  ||.|.|| .|.||... 
fkelre.lkpld.tcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

DADDKN-----NFWPEK
   .|.      .|||.
lekekgkvkchrywPes
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1026-1109 5.6e-11 37.0 In-house 35-116 (307) alignment 
Range on Protein: 1026-1109
Range on HMM: 35-116/307.0
MAELTCNETKNRPAGPLAPSHMRVKLQrvMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDA
.  ...|  |||     .  . |. ..  .. | |||| ||..|  . || .| || |.|||.  || |. . .   ...| ..
veafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckv
0043147 (Phosphotyrosine protein) phosphatases II 1059-1123 8.5e-11 37.4 In-house 4-69 (172) alignment 
Range on Protein: 1059-1123
Range on HMM: 4-69/172.0
GSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDA-DDKNNFWPEKEDYQ
|||||||...  .  |...|. |.|. ||.. ||||..| . ..|| | .   |. .....   |.
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqyl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 982-1108 8.9e-11 36.0 In-house 7-129 (305) alignment 
Range on Protein: 982-1108
Range on HMM: 7-129/305.0
SRPIKEQWVISLKqRSGVLKMGGFIHKRYNELKEFMKMIEYNNFMAeLTCNETKNRPAGPLAPSHMRVKLQRVMedlGSDYINANFVGSPLYP-KSYIIA
..|| ||.|.      || |.   . .  .  .  |  . .|   .    ..|||| .   .  .  |||..      |||| ||.|| |. | | .| |
thpiveqfvlral.dvgvdklreefrglakytrpdmtqvafnanqs.adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrfica

QWPMENTIPTFWRMIWETNASVIVVLGD
| |...||  || |. . .   ||.|  
qgpldqtidefwwmviqnkveqivmlck
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1043-1119 2.2e-10 35.0 In-house 44-118 (267) alignment 
Range on Protein: 1043-1119
Range on HMM: 44-118/267.0
APSHMRVKLQRVMEDlgsdYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGD--ADDKNNFWPEK
   . || |.   |.    |||| .| .    . .|. | |..|||  |. .| . . .|||.|     |. . ||| |
pyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPk
0046846 (Phosphotyrosine protein) phosphatases II 1052-1125 5e-10 34.9 In-house 4-78 (176) alignment 
Range on Protein: 1052-1125
Range on HMM: 4-78/176.0
QRVMEDLGSDYINANFVGSPLypksYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDK-----NNFWPEKEDYQLH
..  .||..||||||.. ...    .|. |.|...|...|..|..| . ...| | .  ..      |.||| |.....
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiq
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1010-1112 7e-10 33.1 In-house 28-125 (305) alignment 
Range on Protein: 1010-1112
Range on HMM: 28-125/305.0
YNELKEFMKMIEYNNFMAelTCNETKNRPAGPLAPSHMRVKLQRvmeDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDA
.. .| |  .   . |    . .. |||        . ||||.        .|| ||.| .|  || .| .| |.|.|   || | .. .   | .| . 
fvamkrfndfekmkafke..aqeagknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnl

DDK
 .|
lek
0036282 (Phosphotyrosine protein) phosphatases II 1059-1125 1.3e-09 33.5 In-house 1-67 (174) alignment 
Range on Protein: 1059-1125
Range on HMM: 1-67/174.0
GSDYINANFVGSPLYPKSYIIAQWPMEntiptFWRMIWETNASVIVVLGDADDKN-----NFWPEKEDYQLH
|||||||....    .. .|. |.|..     ||.|..| . ...| | .   ..     |.|||. ..  .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredler
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1018-1108 4e-09 30.9 In-house 33-115 (288) alignment 
Range on Protein: 1018-1108
Range on HMM: 33-115/288.0
KMIEYNNFMAELTCNETKNRPAGplapSHMRVKLQrvmeDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGD
 .   ..|.|. | .  .| |         ||||.    |    ||.|| | |  |..  | || |.. ||  .|.|. |..   ||.| .
sidiidsfianptrdryenlprc....ditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlce
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1032-1109 6.8e-09 29.7 In-house 52-128 (310) alignment 
Range on Protein: 1032-1109
Range on HMM: 52-128/310.0
NETKNRPAGPLAPSHMRVKLQrVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDA
.  ||| .  .     ||||. .      ||| ||.| .    ...| .| |.. ||  |||||..  |  |..|  .
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1075-1192 1.2e-08 29.3 In-house 4-111 (198) alignment 
Range on Protein: 1075-1192
Range on HMM: 4-111/198.0
KSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDaDDKNnfwpeKE-DYQ-LHPAVILGEWYTDSLYVRTDKVTAlcKGEYpnGITVSILNTDNTVIKnt
. || .| |. .|.  ||.|.||| .  ||.. | |.||     || ||   .|..  |     || | |  .|.  | .|   ||. ||  . |     
rryiatqhplretladfwqmvwetgsghivmvnd.dqkn.....keadypfywpttesgtgkygslsvttktitt..kpdy..titaliltnnttapp..

SISTQVNDQLMITGEITVPN
|       |.    | | ||
streishyqftswkekttpn
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1075-1192 1.3e-08 29.3 In-house 5-112 (199) alignment 
Range on Protein: 1075-1192
Range on HMM: 5-112/199.0
KSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDaDDKNnfwpeKE-DYQ-LHPAVILGEWYTDSLYVRTDKVTAlcKGEYpnGITVSILNTDNTVIKnt
. || .| |. .|.  ||.|.||| .  ||.. | |.||     || ||   .|..  |     || | |  .|.  | .|   ||. ||  . |     
rryiatqhplretmadfwqmvwetgsghivmvnd.dqkn.....keadypfywpttesgtgkygslsvttktitt..kpdy..titaliltnnttapp..

SISTQVNDQLMITGEITVPN
|       |.    | | ||
streishyqftswkekttpn
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1021-1114 4.4e-08 27.0 In-house 23-115 (332) alignment 
Range on Protein: 1021-1114
Range on HMM: 23-115/332.0
EYNNFMAELTCNETKNRPAGPLAPSHMRVKLQrvMEDLGSDYINANFVGSPLYPKSYIIAQWPMEN-TIPTFWRMIWETNASVIVVLGDADDKNN
 | |   ..  |   ||     .  | ||.|    .|   |. ||..|       .||.|| |... |   ||||. | . |.|.|.|| |.|..
typntydkflnnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
0051429 (Phosphotyrosine protein) phosphatases II 1060-1139 5e-08 28.5 In-house 4-87 (272) alignment 
Range on Protein: 1060-1139
Range on HMM: 4-87/272.0
SDYINANFVGSPLY---PKSYIIAQWPMENTIPTFWRMiWETNASVIVVLGDAD--DKNNFWPEKEDYQLHPAVILGEWYTDSLY
|.||||..|| . .   |. .. .. |...|.  |||. .| . ..|| | . .  ........ .. ...   ||.. ... ||
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptily
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1034-1113 7.5e-08 26.5 In-house 49-142 (350) alignment 
Range on Protein: 1034-1113
Range on HMM: 49-142/350.0
TKNRPAGPLAPSHMRVKLQRVM--------EDLGSDYINANFVGSP-----LYPKS-YIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN
.|||    |   | ||||.. .           ..||||||..  .       |.  || .| |. .|.  |...| . .  ||. | . .. |
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1052-1113 7.3e-07 23.2 In-house 67-128 (301) alignment 
Range on Protein: 1052-1113
Range on HMM: 67-128/301.0
QRVMEDLGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKN
 .|..|     | ||.. ..  |. .|..| |..||   || |.   .   ||.||   .|.
vevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1025-1125 8.3e-07 22.7 In-house 48-148 (302) alignment 
Range on Protein: 1025-1125
Range on HMM: 48-148/302.0
FMAELTCNETKNRPagplAPSHMRVKLQRVMEdlgsDYINANFVGSPLYPKSYIIAQWPMENTI---PTFWRMIWETNASVIVV-LGDADDKN---NFWP
| ..|  | ... |    .. . .|||.   .    .|.||  |  |   .| |.|| |  ..     .||||... .   .|. .|. . |.   ...|
fkknlkknqsedvp....ildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfp

-EKEDYQLH
 . .||. .
kksgdykey
0049260 (Phosphotyrosine protein) phosphatases II 1072-1117 9.6e-07 24.1 In-house 6-51 (152) alignment 
Range on Protein: 1072-1117
Range on HMM: 6-51/152.0
LYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDADDKNNFWP
 .|. .|..|.|..||.. ||||..| ....||.| . .... .. 
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkc
subfamily_eak_pd Subfamily eak 1048-1109 3.5e-06 20.6 In-house 67-127 (332) alignment 
Range on Protein: 1048-1109
Range on HMM: 67-127/332.0
RVKLQRVMEDlGSDYINANFVGSPLYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDA
 |.|   . .    ||||  .  .   . ||..  . |. .. ||.|. | ..  || | . 
lvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlled
0044763 (Phosphotyrosine protein) phosphatases II 1046-1136 3.7e-06 22.2 In-house 4-90 (178) alignment 
Range on Protein: 1046-1136
Range on HMM: 4-90/178.0
HMRVKLQRVMEDLGSDYINANFVGsplyPKsYIIAQWPMentiPTFWRMIWETNASVIVVLGDADDK-----NNFWPEKEDYQLHPAVILGEWYTD
. ||.|. ..  ..||||||...     |  ......|.    . ......| . ..|| | . .       .  |||....| .   | .   .|
rtrvllsnleglersdyinaseil....pg.lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpd
Orthoreo_P10 Orthoreovirus membrane fusion protein p10 513-573 5.3e-06 13.6 Pfam-A 35-92 (98) alignment 
Range on Protein: 513-573
Range on HMM: 35-92/98.0
SSVLIISIP--AGGGGVcfgLIVLIVCCLILCCvYFKNrKRAAENHEFLDESTAFDGGQFNAL
.|.||   |  | |||.   ...... .|. || . |  |. | .. |  |  |.  |. || 
tssliaywpylaagggl...iviilllallycc.kakv.kadavrsvfrrelvalssgkvnaa
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1034-1109 7e-06 19.9 In-house 58-128 (290) alignment 
Range on Protein: 1034-1109
Range on HMM: 58-128/290.0
TKNRPAGPLAPSHMRVKLQrvmEDLGSDYINANFVGSplYPKSYIIAQWPMENTIPTFWRMIWETNASVIVVLGDA
.|||          || |.   .    ||. ||.|        .|..| ....|.  .|||. ......||.| . 
kknrykdvvcndktrvilk...dGydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlcel