Gene AquePTP-sf1-4 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily AquePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP145_AA protein Get Run
AqueP145_AA_747-884 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 754-886 1.3e-82 268.6 In-house 1-146 (169) alignment 
Range on Protein: 754-886
Range on HMM: 1-146/169.0
HKGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINAKMIWETNASVIVVLGGTDDKNNFWPEKEDYQLHPAVILGEW
||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||.||||||||||||||.|||||||||||||||||||||||||
hkgynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyinarmiwetnasvivvlGdtddknnfwpekedyqlhpavilGew

YTDSLYVRTDKFQ------------MLVFHQHKRIVTK-LQLLHKN
|||||||||||..            .||.|.... ||. |.|||..
ytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhys
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 753-886 2.4e-82 267.9 In-house 1-147 (169) alignment 
Range on Protein: 753-886
Range on HMM: 1-147/169.0
IHKGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINAKMIWETNASVIVVLGGTDDKNNFWPEKEDYQLHPAVILGE
|||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||.||||||||||||||.||||||||||||||||||||||||
ihkgynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyinarmiwetnasvivvlgdtddknnfwpekedyqlhpavilge

WYTDSLYVRTDKFQML------------VFHQHKRIVT-KLQLLHKN
||||||||||||....            |.|.... || ||.||| .
wytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhys
0051299 (Phosphotyrosine protein) phosphatases II 754-847 9.5e-14 47.0 In-house 26-148 (288) alignment 
Range on Protein: 754-847
Range on HMM: 26-148/288.0
HKGYNELKEFMKTieYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINA---------------------------KMIWETNASVIVVL
.. ..|| ..  .  ..   | | .| .|||    |.  |.||||. . .. |||||||                           .|.|| | .|||.|
leefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvml

GGTDDKN-----NFWPEkEDYQLHPA
 ......      .||. .... .  
tklvelgrekcaqYwpl.ggsltygd
0046845 (Phosphotyrosine protein) phosphatases II 755-884 9.9e-14 46.8 In-house 4-157 (284) alignment 
Range on Protein: 755-884
Range on HMM: 4-157/284.0
KGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEN-LGSDYINA--------------------------------KMIWETNAS
. . ||  .  .....   | | .| .|||    |.  |.||||... ..  .||||||                                .|.|| |..
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

VIVVLGGTDDKNN-----FWPEKEDYQLHpavilgewytDSLYVRTDKFQMlvfhQHKRIVTKLQLLH
|||.| .......     .||...... .          . . |.. . ..    ..  .|..|.| .
vIVmltelvengrekcaqYwplegevlty..........gdftvtllseev....kddytvrtleltn
0039614 (Phosphotyrosine protein) phosphatases II 754-875 3e-13 45.4 In-house 35-169 (297) alignment 
Range on Protein: 754-875
Range on HMM: 35-169/297.0
HKGYNELKEFMKtieyNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEN-LGSDYINA----------------------------KMIWETNASVIV
.. . ||...      .   |.| .| .|||    |.  |.||||. ...  |.||||||                            .|.|| . .|||
llefeellslkp....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtviv

VLGGTDDKN----NFWPEKEDyqlhpavilgewYTDSLYVRTDKFQMlvfhQHKR
 |  .....     .|||...            . . . |.. |...     .  
mLtklvelgrkcaqywpeegg............tygdftvtllkveh....ldgy
0040438 (Phosphotyrosine protein) phosphatases II 755-845 3.3e-13 45.1 In-house 19-140 (317) alignment 
Range on Protein: 755-845
Range on HMM: 19-140/317.0
KGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINA---------------------------KMIWETNASVIVVLG
. ..| ..... . ..  .||| .|  |||    |   |.||||. . . |.||||||                           .|.|| . .||| | 
alleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

GTDDKN-----NFWPEkEDYQLH
 .....      .||. .... .
eleelgrekcaqYwpl.getlty
0047943 (Phosphotyrosine protein) phosphatases II 753-843 6.6e-13 44.2 In-house 14-132 (273) alignment 
Range on Protein: 753-843
Range on HMM: 14-132/273.0
IHKGYNELKEFMKtiEYNNFMAELTCNETKNRPAGPLAPSHTRVKLqrvmENLGSDYINA---------------------------KMIWETNASVIVV
... ...|... .  ...   |.| .| .|||    |.  |.||||    .. |||||||                           .|.|| |..|||.
lleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

LGGTDDKNN-----FWPEKEDY--Q
|  ......     .||....   .
LtelvelgrekcaqYwpleggelsl
0043336 (Phosphotyrosine protein) phosphatases II 757-846 7.7e-13 44.0 In-house 23-142 (278) alignment 
Range on Protein: 757-846
Range on HMM: 23-142/278.0
YNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINA---------------------------KMIWETNASVIVVLGGT
..| .|...   ..  .|.| .| .|||    |.  |.||||. . . |.||||||                           .|.|| . ..||.| . 
llefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtel

DDKN-----NFWPekEDYQLHP
....      .||  .... . 
velgrvkcaqYwp..ggsltyg
0045450 (Phosphotyrosine protein) phosphatases II 743-843 9.4e-13 44.0 In-house 19-160 (307) alignment 
Range on Protein: 743-843
Range on HMM: 19-160/307.0
RSGVLKMGGFIHKGYNELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMEN-LGSDYINA-----------------------------
.  .|.    ..| ...|... ... ..  .|.| .| .|||    |.  ||||||. . ..  .||||||                             
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

------KMIWETNASVIVVLGGTDDKNN-----FWPEKEDYQ
      .|.|| . .||| | .......     .||......
tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeel
0050432 (Phosphotyrosine protein) phosphatases II 752-843 9.7e-13 43.6 In-house 43-163 (308) alignment 
Range on Protein: 752-843
Range on HMM: 43-163/308.0
FIHKGYNELKEFMKtiEYNNFMAELTCNETKNRPAGPLAPSHTRVKLqrvmeNLGSDYINA-----------------------------KMIWETNASV
.... ..|| ..     .. . |.| .| .|||    |.  |.||||     . |||||||                             .|.|| | .|
lleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVVLGGTDDK-----NNFWPEKED--YQ
||.|  ....       .||....  ..
IvmLtklvengrekcaqYwplelgggsl
0036941 (Phosphotyrosine protein) phosphatases II 768-844 1.8e-11 39.3 In-house 28-133 (297) alignment 
Range on Protein: 768-844
Range on HMM: 28-133/297.0
EYNNFMAELTCNETKNRPAGPLAPSHTRVKLqrvmENLGSDYINAK---------------------------MIWETNASVIVVLGGTDDKNN-----F
 ..   |.| .| .|||    |.  ||||||    .. |||||||                            |.|| | .|||.|   ....      .
lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WPEK-EDYQL
||.. .... 
wpleegeslt
0040439 (Phosphotyrosine protein) phosphatases II 772-849 5.2e-10 34.8 In-house 4-142 (249) alignment 
Range on Protein: 772-849
Range on HMM: 4-142/249.0
FMAELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINA---------------------------KMIWETNASVIVVLGGTDDKN-----NFWPEk
 .|.| .|  |||    |.. |.||||. . .  .||||||                           .|.|| . .||| |  .. ..      .||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

EDYQLHP------------------------------AVI
.... .                                 .
ggsleygdftvtllsvevkddytvrtleltnlydgesrtv
0042113 (Phosphotyrosine protein) phosphatases II 774-846 8.2e-10 34.0 In-house 4-107 (245) alignment 
Range on Protein: 774-846
Range on HMM: 4-107/245.0
AELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINAK---------------------------MIWETNASVIVVLGGTDDKN-----NFWPEkED
|.| .| .|||   .|.  ||||||. . ..|.||||||                            |.|| . ..|| |  .....      .||. ..
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

YQLHP
.. . 
sltyg
0045098 (Phosphotyrosine protein) phosphatases II 773-848 2.9e-08 28.9 In-house 27-122 (278) alignment 
Range on Protein: 773-848
Range on HMM: 27-122/278.0
MAELTCNETKNRPAGPLAPSHTRVKlqrvmenlgsDYINA-------------------------KMIWETNASVIVVLGGTDDKN-----NFWPEkEDY
 | . .|  |||    |.  |.|||          |||||                         .|.|| . .||| | .  ...      .||| ...
palylgnldknRykdilpydhsrVk..........dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggs

QLH-PAV
. . . .
ltygdft
subfamily_PTPRD_pd Subfamily PTPRD 759-814 4.7e-08 27.1 In-house 28-83 (564) alignment 
Range on Protein: 759-814
Range on HMM: 28-83/564.0
ELKEFMKTIEYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINAKM
| |.. .  . .   |.  .|  ||| |  .|  |.||.|..|  . |||||||  
eykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsf
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 756-815 1.7e-07 25.6 In-house 25-82 (318) alignment 
Range on Protein: 756-815
Range on HMM: 25-82/318.0
GYNELKEFMKTieYNNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINAKMI
 |..|.   .|    .. .   .|..||| |  ||  ||||||| . .. |||||||. |
eyerlsrseet..vtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi
subfamily_PTPRB_pd Subfamily PTPRB 755-817 1.8e-07 25.5 In-house 29-89 (293) alignment 
Range on Protein: 755-817
Range on HMM: 29-89/293.0
KGYNELKEFMKTIEynNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINAKMIWE
. |.|||.. |. .    .|||..|..|||    |.  |.||||. . .. |||||||  | .
eeyeelkavgkdqa..vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipg
0037934 (Phosphotyrosine protein) phosphatases II 773-867 2.5e-07 26.0 In-house 4-125 (243) alignment 
Range on Protein: 773-867
Range on HMM: 4-125/243.0
MAELTCNETKNRPAGPLAPSHTRVKLqrvmENlgSDYINAK----------------------------MIWETNASVIVVLGGTDDK-----NNFWPEK
.| | .| .|||  . |.  |.||||    |.  ||||||                             |.|| . .||| |  ....       .||..
iallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpge

EDYQLHPAVILGEWYTDSLYVRTDKFQM
. |      .|.| ..|.  ||| . ..
vtygdftvtllseehlddytvrtlllen
LRR_6 Leucine Rich repeat 87-107 4.2e-06 16.4 Pfam-A 4-24 (24) alignment 
Range on Protein: 87-107
Range on HMM: 4-24/24.0
LLSLGLSCNKIGDEGAKALAE
| || || |.|||||..|||.
LtsLdLsnNqigdeGlsaLan
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 754-819 7.5e-06 20.2 In-house 24-87 (288) alignment 
Range on Protein: 754-819
Range on HMM: 24-87/288.0
HKGYNELKEFMKTIEynNFMAELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINAKMIWETN
.. || | .. || .  . ...|. |..|||    |.  ..||||. . |. |.|||||. | ...
seeynsLaalektks..vtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgek
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 754-813 7.6e-06 20.4 In-house 30-90 (298) alignment 
Range on Protein: 754-813
Range on HMM: 30-90/298.0
HKGYNELKEFMKTIEYNN-FMAELTCNETKNRPAGPLAPSHTRVKLQRVMENLGSDYINAK
.. ...|..  ..|| ..  .|. . |. ||| |  .|  ..|| |... ..  |||||| 
alefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAs