Gene AquePTP-Un-6 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP147_AA protein Get Run
AqueP147_AA_65-309 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 67-310 1.5e-175 575.5 In-house 1-244 (244) alignment 
Range on Protein: 67-310
Range on HMM: 1-244/244.0
ALEYEVSRLQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKEGSDYINANYIQGSQNIIRPDPSVMKDAFNPNNSWKN
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
aleyevsrlqdeevakeefvglsdhtreflqtnavlsanatknryinilpfdetrvilssskkegsdyinanyiqgsqniirpdpsvmkdafnpnnswkn

REGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDEYWPDSEPLEWYEEDITVTLTDRDE
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
regaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpdseplewyeeditvtltdrde

FKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTPNDHFIMV
||||||||||||||||||||||||||||||||||||||||||||
fknikasnleiesdmneshqaltmfqisnwpsdgttpndhfimv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 170-305 1.5e-81 265.2 In-house 1-130 (130) alignment 
Range on Protein: 170-305
Range on HMM: 1-130/130.0
AGLPFDFNRVPlskgsmGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDEYWPDSEPLEWYEEDITVTLTDRDEFKN
|.|.|...|..      |||||||||||.|||||||.||||||||||||||||||||.||||||||||||||||||||||||||||||.|||||||||||
aalefevsrlq......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyeediivtltdrdefkn

IKASNLEIESDMNESHQALTMFQISNWPSDGTTPND
|||||||||||.||||||||||||||||||||||||
ikasnleiesdlneshqaltmfqisnwpsdgttpnd
0036941 (Phosphotyrosine protein) phosphatases II 157-303 2.1e-33 111.3 In-house 34-185 (297) alignment 
Range on Protein: 157-303
Range on HMM: 34-185/297.0
AFNPNNSWKNREGAGLPFDFNRVPLskGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLE
| .|.|  |||    ||.|..|| |  .. |. |||||.| . ... ..|.||.|| .|  |||.|..| .|.|.|.| ...|      ..|||. |. .
allpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeges

WYEEDITVTLTDRDE--FKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTP
.. .|.||||.. ..  .....  .||..   |. .  .|.|.. .|| .|. .
ltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe
0040438 (Phosphotyrosine protein) phosphatases II 149-307 3.9e-33 110.5 In-house 30-192 (317) alignment 
Range on Protein: 149-307
Range on HMM: 30-192/317.0
PDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPLSKGSM--GNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----
 ... .. |  |.|  |||    ||.|..|| ||  .   ...|||||.| .  .. ..|.||.|| .|  |||.|. | .|.|.| | . || .     
lkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekca

EYWPDsEPLEWYeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHF
.|||. .    | .|.||||.. .| ..|.  .||.| . .. .  .| |.  .|| |...| .. 
qYwpl.getlty.gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp.dhgvppspd
0050432 (Phosphotyrosine protein) phosphatases II 157-309 5.9e-33 109.9 In-house 63-219 (308) alignment 
Range on Protein: 157-309
Range on HMM: 63-219/308.0
AFNPNNSWKNREGAGLPFDFNRVPLskgSMGNTYINASFVGCL--GRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEP
|  |.|  |||    ||.| .|| |   . |..|||||.| .   ... ..|.||.|| .|  |||.|. | .|.| |.| . .|      ..|||... 
allpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelg

-LEWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHFIM
   .. ...||||.. .......  .||..   ..    .| |.  ||| |. .|..  |.
ggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp.dhgvPpspeil
0051299 (Phosphotyrosine protein) phosphatases II 155-306 1.3e-32 108.8 In-house 42-201 (288) alignment 
Range on Protein: 155-306
Range on HMM: 42-201/288.0
KDAFNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDs
. |  |.|  |||    ||.| .|| ||   |. |..|||||.. .  .. ..|.||.|| .|  |||.|. | .|.| |.| ...|      . |||. 
saallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.

EPLEWYeEDITVTLTDRDEFKNIKASNLEIESD----MNESHQALTMFQISNWPsDGTTPNDH
.  . | .||||||.. .......  .||..       .. ..  | |.  ||| |  .|.. 
ggslty.gditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp.dhgvpdsp
0047943 (Phosphotyrosine protein) phosphatases II 155-305 1.3e-32 108.7 In-house 31-185 (273) alignment 
Range on Protein: 155-305
Range on HMM: 31-185/273.0
KDAFNPNNSWKNREGAGLPFDFNRVPLskGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEP
. |  |.|  |||    ||.| .|| |  |. |. |||||.| .  .. ..|.||.|| .|  |||.|. | .|.|.|.| ...|      . |||... 
svallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwplegg

L-EWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTPND
  ... ...||||.. .......  .||...  ..     | |.  .|| .|. |. 
elsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppsl
0046845 (Phosphotyrosine protein) phosphatases II 156-308 9.9e-32 105.9 In-house 22-186 (284) alignment 
Range on Protein: 156-308
Range on HMM: 22-186/284.0
DAFNPNNSWKNREGAGLPFDFNRVPLSKGSMG---NTYINASFVGCL-----GRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DE
 |  |.|  |||    ||.| .|| |.  . .   ..|||||.| .       .. ..|.||.|| .|  |||.|..| .|.|.|.| . .|      . 
vallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaq

YWPDSEPLEWYeEDITVTLTDRDEFKNIKASNLEIESDM-NESHQALTMFQISNWPsDGTTPNDHFI
|||...   .| .|.||||..........  .||..    .. .  .| |.. .|| |  .| .  .
Ywplegevlty.gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp.dhgvppsped
DSPc_SM00195 154-305 1.4e-31 105.2 In-house 18-179 (263) alignment 
Range on Protein: 154-305
Range on HMM: 18-179/263.0
MKDAFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPD
...|  ..|. |||    ||.| .|| |.|     |..||||... .  .. .||.||.|| .|  |||.|..|..|.. |.| . ||.     |.|||.
tteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpe

SEPLEWYEEDITVTLTDRDEFK-NIKASNLEIESDMNESHQALTMFQISNWPSDGTT--PND
..  ..  ..|.|.|.. .. | .|.  .||.. . .| .. .| .|. |||  |.   ...
esggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstks
PTPc_SM00194 154-305 1.4e-31 105.2 In-house 18-179 (263) alignment 
Range on Protein: 154-305
Range on HMM: 18-179/263.0
MKDAFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPD
...|  ..|. |||    ||.| .|| |.|     |..||||... .  .. .||.||.|| .|  |||.|..|..|.. |.| . ||.     |.|||.
tteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpe

SEPLEWYEEDITVTLTDRDEFK-NIKASNLEIESDMNESHQALTMFQISNWPSDGTT--PND
..  ..  ..|.|.|.. .. | .|.  .||.. . .| .. .| .|. |||  |.   ...
esggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstks
0039614 (Phosphotyrosine protein) phosphatases II 154-308 1.4e-30 102.2 In-house 48-204 (297) alignment 
Range on Protein: 154-308
Range on HMM: 48-204/297.0
MKDAFNPNNSWKNREGAGLPFDFNRVPLSKGS---MGNTYINASFVGCLGR-TAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE----DEYWP
.. |  |.|  |||    ||.|..|| |.      ....|||||.| .  . | ..|.||.|| .|  |||.|. | .|.|.| | . .|     ..|||
ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywp

DSEPlewYEEDITVTLTDRDEFKNIKASNLEIESdmNESHQALTMFQISNWPsDGTTPNDHFI
...    . .|.||||.. .. ....  .||..   |.    .|.||  .|| |...|... .
eegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwp.dhgvppslel
0043336 (Phosphotyrosine protein) phosphatases II 148-308 4.8e-30 100.4 In-house 31-194 (278) alignment 
Range on Protein: 148-308
Range on HMM: 31-194/278.0
RPDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED----
. ..  .. |  |.|  |||    ||.|..|| ||  .  ....|||||.| .  .. ..|.||.|| .|  |||.|. | .|...|.| . .| .    
sfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkc

-EYWPdsEPLEWYeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHFI
 .|||  .  . | .|.||||.. .......  .||..   .   .  | ..  .|| |...| .  .
aqYwp..ggslty.gdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsl
Y_phosphatase Protein-tyrosine phosphatase 163-306 5.7e-30 99.8 Pfam-A 2-152 (235) alignment 
Range on Protein: 163-306
Range on HMM: 2-152/235.0
SWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLEWYEEDI
. |||    ||.|..|| |.. .  . ||||..|    .. ..|.||.|| .|  |||.|.....|.|.|.| |.||.     ..|||..|  . . .||
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TVTLT-DRD-EFKNIKASNLEIESDMNES-HQALTMFQISNWPsDGTTPNDH
.|.|. .   . |..  ..||.... .|| .. ...... ||| | ..|.. 
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpesp
Y_phosphatase Protein-tyrosine phosphatase 163-306 5.7e-30 99.8 In-house 2-152 (235) alignment 
Range on Protein: 163-306
Range on HMM: 2-152/235.0
SWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLEWYEEDI
. |||    ||.|..|| |.. .  . ||||..|    .. ..|.||.|| .|  |||.|.....|.|.|.| |.||.     ..|||..|  . . .||
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TVTLT-DRD-EFKNIKASNLEIESDMNES-HQALTMFQISNWPsDGTTPNDH
.|.|. .   . |..  ..||.... .|| .. ...... ||| | ..|.. 
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpesp
subfamily_PTPRD_pd Subfamily PTPRD 153-301 5.8e-30 99.4 In-house 39-192 (564) alignment 
Range on Protein: 153-301
Range on HMM: 39-192/564.0
VMKDAFNPNNSWKNREGAGLPFDFNRVPLS--KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWP
 .. | .| |  |||    ...| .|| ||  .|  |  ||||||.    .  .|| ||.|||.| .|||.|. |..... | | ..||...     |||
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

DSEpLEWYeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGT
...  | | ...||||..  |....   .....   ... .  . |.  .||. | 
ekg.tety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgv
0045450 (Phosphotyrosine protein) phosphatases II 157-304 9.8e-30 99.7 In-house 50-213 (307) alignment 
Range on Protein: 157-304
Range on HMM: 50-213/307.0
AFNPNNSWKNREGAGLPFDFNRVPLSKGS---MGNTYINASFV--------GCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED----
|  |.|  |||    ||.| .|| ||  .    .. |||||.|        ..  .. ..|.||.|| .|  |||.|. | .|.|.| | . .| .    
allpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekc

-EYWPDSePLEWYEEDITVTLTDRDEFKNIKASNLEIESD-MNESHQALTMFQISNWPSDGTTPN
 .||||.   |.. ...||||.. .. ....  .||..    .. .  .| |.  .|| .|. |.
aqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 157-308 2.1e-29 97.7 In-house 51-207 (298) alignment 
Range on Protein: 157-308
Range on HMM: 51-207/298.0
AFNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEP
| .|.|  |||    ...|. || |.|  .    .||||||.    ..  .|.||.||  |  |||.|. |......|.| ..|| |.     ||||.. 
arkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk

lEWYeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTPNDHFI
 | | ..|||.|  ..|| ..   .|....  .|... . ... ..||. |.. | . .
.ety.geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsv
0040439 (Phosphotyrosine protein) phosphatases II 159-305 9e-28 93.0 In-house 8-159 (249) alignment 
Range on Protein: 159-305
Range on HMM: 8-159/249.0
NPNNSWKNREGAGLPFDFNRVPLS--KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLE
 |.|  |||    ||.|..|| ||  .|  .. |||||.. .  .. ..|.||.|| .|  |||.|. | ...|.| | | .|      ..|||....||
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsle

WyeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTPND
.  .|.||||.. .......  .||..   . ..   . .|. .|| .|. |. 
y..gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsf
0045098 (Phosphotyrosine protein) phosphatases II 145-307 1.4e-27 92.3 In-house 16-178 (278) alignment 
Range on Protein: 145-307
Range on HMM: 16-178/278.0
NIIRPDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPlskgsmgnTYINASFVGCLgrTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE----
... ..|| . .|  ..| .|||    ||.|..||          |||||.. .   . ..|.||.|| .|  |||.|. | ...|.| | ...|     
llllgipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

-DEYWPDSEPLEWyeEDITVTLTDRDEFKNIKASNLEIESD----MNESHQALTMFQISNWPSDGTTPND---HF
 ..|||....|..  .|.||||.. ......    |...       .     .|.... .||  |. ...   .|
caqywpeggslty..gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksf
0042113 (Phosphotyrosine protein) phosphatases II 158-308 4.2e-27 90.6 In-house 5-159 (245) alignment 
Range on Protein: 158-308
Range on HMM: 5-159/245.0
FNPNNSWKNREGAGLPFDFNRVPLSKGSMG--NTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDsePL
  |.|  |||    ||.|..|| ||  .    ..|||||.|..  .|  .|.||.||..|  |||.|. | .....| | . ||      ..|||.    
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

EWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHFI
... .|.||||.. . .....  .||.. . .  ..  . ..  .|| |...|... .
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp.dhgvpdllel
subfamily_PTPRG_pd Subfamily PTPRG 155-308 2.9e-26 86.8 In-house 40-205 (563) alignment 
Range on Protein: 155-308
Range on HMM: 40-205/563.0
KDAFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGN-TYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGS-----VEEEDEYWPD
. . .|.|  |||.   ...|  || ||. .   ..  ||||...    .. ..| ||.||.||  |||.|. |..|...|..        ...| ||| 
ehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk

SEPLEWyeEDITVTLTDRDEFKNIKASNLEIES-DMN-----ESHQALTMFQISNWPSDGTTPNDHFI
 |....  . ..|||.... .      .| |.   ..     ....  . .. ..||  |.     . 
desety..galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 157-310 4.5e-26 86.4 In-house 41-202 (290) alignment 
Range on Protein: 157-310
Range on HMM: 41-202/290.0
AFNPNNSWKNREGAGLPFDFNRVPLSKGSM----GNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDS
.. ..|. .||    .. | ||..| . |      | ||||...       .||.|| |. .| .||||.. ...| ..|.| .. ||..     |||||
gltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds

EPLEwYEEdITVTLTDRDEFKNIKASNLEIESDMN-ESHQALTMFQISNWPSDGTTPNDHFIMV
.  . |.| ....|..  .....   .||.... . ...| .| .||.||.|.|  .| . |..
dtka.yge.fsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 157-312 1.1e-24 82.1 In-house 42-200 (288) alignment 
Range on Protein: 157-312
Range on HMM: 42-200/288.0
AFNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSV-EEE----DEYWPDSEP
. ...|  |||    ||.|..|| | |     |. |||||..   ... .|| || |||||  |||... |.... .| | .. |..    .|||||.. 
grlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadk

LEWYEeDITVTLTDRDEFKNIKASNLEIESDMNEshQALTMFQISNWPSDGtTPNDHFIMVEV
 . |  ..||||..  | ...   .|..| ...|    .| .|   || .|  |...  ..|.
pknyG.svtvtlveskeledfvlrklllekkkte..leitqyqylaWpdhg.vPeskapllel
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 156-310 1.2e-24 81.9 In-house 41-197 (287) alignment 
Range on Protein: 156-310
Range on HMM: 41-197/287.0
DAFNPNNSWKNREGAGLPFDFNRVPLSkgSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPL
 .  ..|  |||    |. | .||.|      . ||||.|.       ..|... |...|  .|||.. .|.|...|.|   .|.||     |||... .
hniasqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksv

EWyeEDITVTLTDRDEFKNIKASNLEIESDM-NESHQALTMFQISNWPSDGTTPNDHFIMV
     . ...|....  ..    .||.. .. ....| .. .|| ||.| |  ..   |..
vl..GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 151-309 1.3e-24 81.8 In-house 35-197 (318) alignment 
Range on Protein: 151-309
Range on HMM: 35-197/318.0
PSVMKDAFNPNNSWKNREGAGLPFDFNRVPLS--KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEY
 .   .. .| |  |||    |..|  || |.  .|..|  ||||...    |. .|| .| ||..|  |||.|. |..  |.|.|  .||.     . |
tvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhry

WPDSEPLEWyeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTtPNDHFIM
||.... ..  ....|.|... |...    ..... . .|...    ... .||  |. |..   .
WPskgsrsy..gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegv.pesgasl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 66-149 1.9e-24 80.4 In-house 1-109 (130) alignment 
Range on Protein: 66-149
Range on HMM: 1-109/130.0
TALEYEVSRLQDEEVAKEEFVGLSDHTREFLQTNAVLSANATK------NRYINIL-----------------PFD--ETRVILSSSKKEGSDYINANYI
.|||.||||||........||||...|.|.|.|...|......      .||.|.|                 |..  |...|...........|.|...
aalefevsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyeediivtltdrdefknikasnl

QGSQNIIRP
........ 
eiesdlnes
subfamily_PTPRB_pd Subfamily PTPRB 154-310 5.5e-24 79.7 In-house 43-202 (293) alignment 
Range on Protein: 154-310
Range on HMM: 43-202/293.0
MKDAFNPNNSWKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPD
.| | .. |. |||    ||.| .|| |   |.. |. ||||...  .  . |.| || || .|  |||.|..|......|.|  . |.     .||||.
vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa

SEPLEWYeEDITVTLTDRDEFKNIKASNLEIESdmNESHQALTMFQISNWPSDGtTPNDHFIMV
 |    |  ||.|||.  .| ..    .|.||   ..... .. ..   ||  |  |..   ..
deepvly.Gdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhg.vPektktll
0037934 (Phosphotyrosine protein) phosphatases II 156-308 5.5e-24 80.5 In-house 4-154 (243) alignment 
Range on Protein: 156-308
Range on HMM: 4-154/243.0
DAFNPNNSWKNREGAGLPFDFNRVPLsKGsmgNTYINASFVGCLGRtaeYILTQHPLADTSMD----FWKMMLERHVNVLVVLGSVEEE-----DEYWPd
 |  |.| .|||    ||.|..|| | .|   . ||||... ...|   .|.||.|| .|  |    ||.|. | ...|.| | . .|      ..||| 
iallpenlsknrysdilpydhsrvkl.eg...sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

S-EplewYEEDITVTLTDRDEFKNIKASNLEIESDM-NESHQALTMFQISNWPsDGTTPNDHFI
. .    . .|.||||..  ......  .|..|    .. ..  . ..  .|| |...|... .
gev....tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp.dhgvPdsped
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 161-302 2.1e-23 78.0 In-house 45-194 (305) alignment 
Range on Protein: 161-302
Range on HMM: 45-194/305.0
NNSWKNREGAGLPFDFNRVPLSKGSMGN--TYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPLEWY
.|  |||  .  ..|..|. |.. .  .   |||||.|    |  .||..| || .|  |||....| .|...| |  . |...     |||.|.  .  
ankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekke

EEDITVTLTDRDEFKNIKASNLEIES-DMNESHQALTMFQISNWPSDGTT
 ....|.|... ....    .|.|   | ..  .... .|. .|| .|  
fgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvp
subfamily_Ptp69D_pd Subfamily Ptp69D 159-305 4.5e-23 76.8 In-house 45-200 (307) alignment 
Range on Protein: 159-305
Range on HMM: 45-200/307.0
NPNNSWKNREGAGLPFDFNRVPLSKGSM--GNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPLE
. .|  |||  .  .|| .|| |.|  .    .||||||.     . ..|  | |.  |  |||.|. | .|...|.|  ..| ..     |||. .  .
kkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevq

wYEeDITVTLTDRDEFKNIKASNLEIESDMN-----ESHQALTMFQISNWPsDGTTPND
 |. || |.| . .. ..    .|..    .     | .. .. ..  .|. | . |. 
.yg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPev
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 158-301 5.6e-23 76.4 In-house 5-152 (250) alignment 
Range on Protein: 158-301
Range on HMM: 5-152/250.0
FNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED----EYWPDSEPlE
 .|.|  |||    ...|  || | | .      ||||||.     .  .| ||.|| .|  |||.|.||......|.| ...|..    .|||  .. |
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPveka.e

WYeEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGT
 |  |.||.| ...|| ...  .| . .  ..... .  ..  .||  | 
ky.GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgv
subfamily_PTPN12_pd Subfamily PTPN12 157-303 5e-22 73.1 In-house 35-187 (290) alignment 
Range on Protein: 157-303
Range on HMM: 35-187/290.0
AFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEP
. ...|  |||    ||.|..|| ||| .   |. ||||.|.     . ||| .| ||..|  |||.|. | .|...|..  . | .      |||..  
gekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

LEWYEEDITVTLTDRDEFK-NIKASNLEIESDmnESHQALTMFQISNWPSDGTTP
 |   ....|||.. . .. ..    |..| .  . .. .. |.  .||  |.  
eelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPs
subfamily_PTPN23_pd Subfamily PTPN23 161-301 5.9e-22 72.8 In-house 42-186 (288) alignment 
Range on Protein: 161-301
Range on HMM: 42-186/288.0
NNSWKNREGAGLPFDFNRVPLSkgSMGNTYINASFVGCLGRT-AEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLEWYE
 .| |||    ||.| ||| |   .  . |||||||  |  .  ..| || ||. |. |||.|. |....|.|.| | ||      |.||| ..      
lyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

EDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGT
.|..||| .  | ..    .|..|   ..  . ..  |. .||. | 
gdlsvtlksvretethvervlkletldadavksvshlqltsWpelGv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 145-309 8.5e-22 72.6 In-house 31-200 (319) alignment 
Range on Protein: 145-309
Range on HMM: 31-200/319.0
NIIRPDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPLS--KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-
..  ...  .. | ...|. |||    |..|  || ||  .|. | .||||||.    .  ..| || ||..|  |||.|. |... ..|.|  . |.  
llkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklk

----EYWPDSEPLEwYeEDITVTLTDRDEFKNIKASNLEIESDMNES-HQALTMFQISNWPSDGtTPNDHFIM
    .|||. .. | |   ..||| ...| ...  ..|...   .|     .. ||  .|| ..  |..   .
vklkkywpeenfee.y.GrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhd.vPekatsl
subfamily_PTPN6_pd Subfamily PTPN6 156-308 1.4e-21 71.8 In-house 48-207 (306) alignment 
Range on Protein: 156-308
Range on HMM: 48-207/306.0
DAFNPNNSWKNREGAGLPFDFNRVPL-SKGSMGNTYINASFVG--CLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDS
..  |.|  |||  . |||| .|| | ... .|..||||...     | ...|| ||  | .|  |||.|... . .|.|..    |        ||||.
egakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPde

EPLEWyEEDITVTLTDRDEFKNIKASNLEIE-SDMNESHQALTMFQISNWPSDGTtPNDHFI
|  |    .|.|| .. .. .. .  .| ..  . ..... .  ..  .||  |. |.|   
eekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgv.pkdpga
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 159-306 2.1e-20 68.4 In-house 22-169 (284) alignment 
Range on Protein: 159-306
Range on HMM: 22-169/284.0
NPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGsVEEEDEYWPDSEPLEWYEED
 ..|  ||| |  |.|| |.| | .  |  .  ||||||.    |   || || || .|  |||.|. | ..  .|.|   .   .|||     .  . .
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.kdkcsqywplkivikeerfk

ITVTLTDRDEFknIKASNLEIESDMNE-SHQALTMFQISNWPSDGTTPNDH
. |.. .  |       ..|.  | .|   . .. | .  ||  |      
vkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdyps
subfamily_PTPN9_pd Subfamily PTPN9 158-311 2.4e-20 67.8 In-house 38-197 (297) alignment 
Range on Protein: 158-311
Range on HMM: 38-197/297.0
FNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPL
  . |. |||    | .|  || |.|  .     ||||.||    .   .| || ||  |. |||.|. |..| |.|.   |.|.      .|||..|  
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

EWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTtPNDHFIMVE
     |..|.  . .| .. | . |||.   .| .. .| ||.  ||  |. |..   ...
saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGv.Pssaaslld
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 159-305 3.2e-20 67.7 In-house 58-204 (319) alignment 
Range on Protein: 159-305
Range on HMM: 58-204/319.0
NPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGsVEEEDEYWPDSEPLEWYEED
 ..|  ||| .  |.|| |.| | .  |  .  |||||||    |   || .| || .|  |||.|. | ..  .|.|   .   .|||     .  . .
ldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.kdkcsqywplkivikeerfk

ITVTLTDRDEFknIKASNLEIESDMNE-SHQALTMFQISNWPSDGTTPND
. |.. .  .       ..|.  | .|   . .| | .  ||  |     
vkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdyp
subfamily_PTPN3_pd Subfamily PTPN3 153-312 9.2e-20 65.7 In-house 32-196 (280) alignment 
Range on Protein: 153-312
Range on HMM: 32-196/280.0
VMKDAFNPNNSWKNREGAGLPFDFNRVPLSKGSMgnTYINASFVGC----LGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EY
 .. |  |.|  |||    ||.|  || |....    ||||..|       |    || || |||.|. |||.|. |......|.| .. |.      .|
aisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPDSEPLEWYEeDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHFIMVEV
||..|    |  ...|... .|| |..   .| ..   .. .. .. .|  .|| | . |.|.  ..|.
WPetedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWp.dhgvPddsadflef
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 148-302 1.5e-19 65.0 In-house 30-189 (315) alignment 
Range on Protein: 148-302
Range on HMM: 30-189/315.0
RPDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE---
 ||..  . | ...|  ||| .  ||.| .|| |     |  . |||||..  .     || .| ||  .  |||.|.|. .|  .|..   .|.|    
dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc

--YWPDSEPLEWYEEDITVTLTDRDEFKNIKASNLeIESDMNESHQaLTMFQISNWPSDGTT
  |||| .        | |.| . .   .  | .| .  . .||.. .| ||  .||  |. 
rqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrt.vtqfqftewPdkGvd
subfamily_PTPRA_pd Subfamily PTPRA 157-312 1.7e-19 64.9 In-house 53-216 (330) alignment 
Range on Protein: 157-312
Range on HMM: 53-216/330.0
AFNPNNSWKNREGAGLPFDFNRVPLS--KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEP
| . .|  |||    ||.||.|| ||  .|     ||||||.    .  ..| .| |...|  |||.|. |..   .|.|  ..| .|     ||||   
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl

leWYEEDITVTLTDRDEFKNIKASNLEIE--SDMN--ESHQALTMFQISNWPSDGTtPNDHFIMVEV
  .   .|.|.. |  . ...   .. ..  .|.   .... .. |    ||  |  | .   |...
..vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv.PfepiGmlkl
subfamily_CG7180_pd Subfamily CG7180 159-304 1.6e-18 61.4 In-house 39-198 (296) alignment 
Range on Protein: 159-304
Range on HMM: 39-198/296.0
NPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE----YWPDSEpLEW
. .|  |||.   .|.|.||| |.|  |   . ||||..|  . . .||| |. |  .|  .||... ..... .|||  . .  .    |||     | 
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks.keq

YEeDITVTLTDRDEFKNIKASNLEIESD------MNE----SHQALTMFQISNWPSDGTTPN
|  .| | ..  ... |.|  .. .         ...        ...||.  |...   | 
yg.eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 156-306 1.7e-18 61.8 In-house 35-189 (281) alignment 
Range on Protein: 156-306
Range on HMM: 35-189/281.0
DAFNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSE
 .....|  |||      .|  || ...   .. . ||||.||  .   .||| || |. .. ..||.|..|..|...|..    |.       |||| .
askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn

PlEWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHqALTMFQISNWPSDGTtPNDH
  |    |.||. | . | ..    ....| . .|.   .. ..  .||  |  |.. 
s.elkygdvtvkstaeeekatyierkfkleresgetr.eveqlaytaWPdhGv.Patt
subfamily_PTPRK_pd Subfamily PTPRK 159-304 2.3e-18 61.1 In-house 40-190 (314) alignment 
Range on Protein: 159-304
Range on HMM: 40-190/314.0
NPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPLe
. .|  ||| |  |..|  || |    |   . ||||...    |.|..| ||.|| .|  |||..... .   .|.|  . |.      .|||.     
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.

wYeEDITVTLTDRDEFKNIKASNLEIES--DMNESHQALTMFQISNWPSDgTTPN
 | .|| |.| . .  ... .  . .|      | .. .  ||  .||.   .|.
.y.gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPv
subfamily_PTPN13_pd Subfamily PTPN13 159-311 2.9e-18 61.1 In-house 34-190 (273) alignment 
Range on Protein: 159-311
Range on HMM: 34-190/273.0
NPNNSWKNREGAGLPFDFNRVPLSKGSMgntYINASFVGCLG--RTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPLE
. .|  |||    ||.|  ||.|.. .    |||||..       . |||..| || .|  |||.|. |....|.... .  |..      |||.|.  .
kkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkk

WYEED-ITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPNDHFIMVE
   .. ..|.| .  . .. . ..|...    .  . .. ..  .|| |  .|.    ...
lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwP.dhgvPssaaellq
subfamily_PTPN1_pd Subfamily PTPN1 155-300 3.1e-18 60.5 In-house 25-176 (290) alignment 
Range on Protein: 155-300
Range on HMM: 25-176/290.0
KDAFNPNNSWKNREGAGLPFDFNRVPLSKGSMgnTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSE-
..| .|.|  .||     |.|  |. | ...    |||||.|       .||||| ||..|   ||.|. |..   .|.|  | |..     .|||  | 
reaklpenrnlnryrdvspydhsrikleradn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

--PLEWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDG
   |.  .  ..|.|  ... .. . . ||.|    .  . .. |    ||  |
ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfg
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 151-304 4.1e-18 60.2 In-house 27-186 (287) alignment 
Range on Protein: 151-304
Range on HMM: 27-186/287.0
PSVMKDAFNPNNSWKNREGAGLPFDFNRVPLS-KGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVL-GSVEEED----EYW
. ..| | .  .  ||| .  ||.| .|| || .| .|  |||| .|    .  ..| .| |.| |  |||...||... .....   |||      .||
tatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykyw

PDSE-PLEWYeeDITVTLTDRDEFKN-IKASNLE-IESDMNESHqALTMFQISNWPSDGTTPN
|. | |.       .|.| |.|  .       |  |. . .|..  .  ... .||... .| 
PerevPmrvG..GysvvlldydikePeygvralrlidletrear.vvkqldllswPdkvlaPt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 64-144 6.3e-18 59.9 In-house 3-86 (318) alignment 
Range on Protein: 64-144
Range on HMM: 3-86/318.0
ELTALEYEVSRLQDE--EVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQ
.. .||  | ||. .   . .||.  || ..... ..... ..|..||||.|||..|.||| |.   ..|||||||||||.| .
svedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 162-303 2.7e-17 57.8 In-house 51-194 (297) alignment 
Range on Protein: 162-303
Range on HMM: 51-194/297.0
NSWKNREGAGLPFDFNRVPLSKGSM--GNTYINASFVGCLGRtaEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE----YWPDSEPLEwyEE
|  |.|    ||.|..|| |          |.|||||       ..| || |  .|  |||.|.|. .|...|.|   .|.|.    ||.|.   .    
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt..fG

DITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGTTP
|..|.|.  .| .     .||.. . . ... .  .|  .||..    
dvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaver
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 160-302 4.2e-17 56.9 In-house 31-178 (283) alignment 
Range on Protein: 160-302
Range on HMM: 31-178/283.0
PNNSWKNREGAGLPFDFNRVPLSKGSMgnTYINASFVG---CLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPLE
 .|  |||.   .| | .|| |   |   .||||.|.       .  .|| .| || .| .|||||. ....  .|.|  . |. .     |||     .
denkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsed

WYEedITVTLTDRDEFKNIKASNLEIESD-MNESHQALTMFQISNWPSDGTT
. |   |||| .    .     .| .  .   .|   |. .|. .| . |  
yGe..ftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeq
subfamily_PTPRD_pd Subfamily PTPRD 62-142 5.6e-17 56.6 In-house 4-86 (564) alignment 
Range on Protein: 62-142
Range on HMM: 4-86/564.0
PVELTALEYEVSRLQ--DEEVAKEEFVGLSDHtREFLQTNAVLSANATKNRYINILPFDETRVILSSSK-KEGSDYINANYIQG
|.. ..|.  | .|.  ..   .||.  .. . ..|  ..|  .||  |||| ||...|..||.||. . .||||||||..|.|
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 160-311 8.6e-17 56.1 In-house 26-185 (274) alignment 
Range on Protein: 160-311
Range on HMM: 26-185/274.0
PNNSWKNREGAGLPFDFNRVPLSKG-SMGN--TYINASFV-GCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPL
. .. |||  . || .  || |..  |  .  .|||| .. |  ...  |. || ||. | .|||.|. ...|.|.|.|  ..|..|     |.||.| .
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

EWYE--EDITVTLTDRDEFKNIKASNLEIESDMNesHQALTMFQISNWPsDGTTPNDHFIMVE
|  |  .|. .. ..  | .. .  .| ...  .  .. .. .  ..|| |  .|.|   ...
eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWP.dhksPddantlld
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 157-301 1e-16 55.8 In-house 44-190 (315) alignment 
Range on Protein: 157-301
Range on HMM: 44-190/315.0
AFNPNNSWKNREGAGLPFDFNRVP--LSKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED----E-YWPDSep
| . .|  |||    ...|  ||   | .   .  |.||.|.    .   || .| |.. .  |||... | ..  .|.| .. |..    | ||||   
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..

lEWYEEDITVTLTDRDEFKNIKASNLEIESdmNESHQALTMFQISNWPSDGT
 .     ||||. . . ....    | . .  ..  . .  .... ||  | 
.kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 159-297 1.6e-16 55.1 In-house 30-167 (267) alignment 
Range on Protein: 159-297
Range on HMM: 30-167/267.0
NPNNSWKNREGAGLPFDFNRVPLSKGSmgNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE--DEYWPDSEPLEWYEED
  .|  .||   .||.| .||.|..    . |||||.| .  .   .|.|| ||  |  ||.... ...| | |.|  | ..    .||         .|
aeknqernrlddnlpyddtrvilrtke..eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqd

ITVTLTDRDEFKNIKASNLEIESDmNESHQALTMFQISNWP
.||  .   | .. .   ||..   ||| . .|..   .| 
ltvehslekeendyqiitlelkfk.nesahnvtlyyykkwn
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 106-275 5.9e-16 53.1 In-house 48-177 (350) alignment 
Range on Protein: 106-275
Range on HMM: 48-177/350.0
ATKNRYINILPFDETRVILSSSK---------KEGSDYINANYIQGSQNIIRPDPSVmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfv
 .|||| ||||.. .||.|  |           ...|||||||.. ..  .. .|.                                            
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdf...........................................

gclgrtaEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEplewyEEDITVTLTDR-DEFKNIKASNL
        || || ||  |  ||.|..|. .|.|.. | |  |      ..||.. .      .|||| |... ..  .|. | |
.......kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs.....ydditvklaskwenimgindssl
subfamily_PTPN14_pd Subfamily PTPN14 153-305 1.1e-15 52.4 In-house 40-201 (300) alignment 
Range on Protein: 153-305
Range on HMM: 40-201/300.0
VMKDAFNPNNSWKNREGAGLPFDFNRVPLSKGSM-GNTYINASFVGC--LGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYW
... | .|.|  |||    ||.. ||| ||      . ||||| .     |.. .|| .| ||  |  |||.|. | .|...| | . ||.      .|.
llstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf

PDSEP--LEWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGtTPND
|..|    .   .   ||   ... . . .. |...  . . .. . ..|  .|| .|  |.|
PkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhg.vPeD
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 166-306 1.7e-15 51.8 In-house 24-172 (270) alignment 
Range on Protein: 166-306
Range on HMM: 24-172/270.0
NREGAGLPFDFNRVPLSKGS--MGNTYINASFV-GCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEP--LEWYEE
||    ||    || |.. .     .|||| .| |  |....|| .. ||. |  .||.|..|..|. .|..  .||.       ||| .    ..  . 
nRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledg

DITVTLTDRDEFKNIKASNLEIEsDMNESHQALtMFQISNWPSDGTTPNDH
.|.|. .     .   . .|..| .  |... .  |.  .|| .|  ... 
kikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreed
subfamily_PTPN6_pd Subfamily PTPN6 81-144 2.6e-15 51.2 In-house 28-93 (306) alignment 
Range on Protein: 81-144
Range on HMM: 28-93/306.0
AKEEFVGL--SDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKEGSDYINANYIQGSQ
 .|||  |  ..... . ....    |..|||| ||||||.|||||....  ||||||||||....
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkev
subfamily_PTPRN_pd Subfamily PTPRN 149-248 3.3e-15 50.6 In-house 43-150 (297) alignment 
Range on Protein: 149-248
Range on HMM: 43-150/297.0
PDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPLSKGS--MGNTYINASFVG-CLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEE-----E
 .||. . | ...|  |||. | ||.| .|| |.. .    . |||||..     |.. || || |||.|  |||.|. |. | |.| | ..||     .
aepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc

DEYWPDSE
..||||  
krywpdeG
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 156-304 3.4e-15 50.5 In-house 49-200 (290) alignment 
Range on Protein: 156-304
Range on HMM: 49-200/290.0
DAFNPNN-SWKNREGAGLPFDFNRVPLSKGSMGNtYINASFVGclGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEP
. |. |    |||       |  || |. |  |. |. | .|   |  | .|||| .|.|| .|.|.|.|. .| ..|.|  . |.     ..|.|. | 
kifdkntefkknrykdvvcndktrvilkdGydGd.yvhanyvk..GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

LEWYEEDITVTLTDRDE-FKNIKASNLEIESDMNESHQALTMFQISNWPsDGTTPN
      .|||. .  |.  .||.   | .    .  .  |  ..|  || | . ..
evltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswp.dksval
0050432 (Phosphotyrosine protein) phosphatases II 68-143 4.6e-15 51.2 In-house 31-102 (308) alignment 
Range on Protein: 68-143
Range on HMM: 31-102/308.0
LEYEVSRLQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILssskKEGSDYINANYIQGS
| . . .. |    .|||  | . .  .  . | | .| .|||| .|||.| .||.|    .||||||||.|..| 
llkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgy
0051299 (Phosphotyrosine protein) phosphatases II 75-142 5.9e-15 50.9 In-house 19-87 (288) alignment 
Range on Protein: 75-142
Range on HMM: 19-87/288.0
LQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQG
. .    .|||  | . .  . .. |.| .| .|||| .|||.| .||.||. .. ||||||||.||.|
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 161-305 7.7e-15 49.0 In-house 42-191 (515) alignment 
Range on Protein: 161-305
Range on HMM: 42-191/515.0
NNSWKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPD--SEPLE
 |  ||| .  ||.| .|| |   . .  . |.|||..  .     || .| |.  .  |||...|. .|  ....   .|.|      ||||  .. ..
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

WyeEDITVTLTDRDEFKNIKASNLEIESdmNESHQALTMFQISNWPSDGTTPND
.    | | |   .   .    .|..    ..  ...| |.  .||  |. .. 
f..Gsikvelvsleactggikrkltvlk..gddsrtvtqfhfteWPdkGvpkht
fn3 Fibronectin type III domain 1415-1495 8.8e-15 47.8 Pfam-A 2-84 (85) alignment 
Range on Protein: 1415-1495
Range on HMM: 2-84/85.0
APTNFRFTEINFTYVQLAWDPPEPQNGIINLYQIDWERGGRGD-SIRSILPDIR-SIRVSGLTGDVTYTFKIKAQTSAGFGNE
||.|....|.. |...| |.||....| |  |.....  | |. . .  .|    |  ..||. . .|.|...|.. || | |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 149-301 1.3e-14 48.4 In-house 32-147 (392) alignment 
Range on Protein: 149-301
Range on HMM: 32-147/392.0
PDPSVMKDAFNPNNSWKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDeywpd
|| .  . | .. |  ||| .  ||.| .|| |     .  . |.|||.. ..     || .| | | .  |||.|... .|  ....  ..| |     
pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....

seplewyeeditvtltdrdefknikasnleiesdMNESHQALTMFQISNWPSDGT
                                    ..... . |....|| .. 
..................................kgddartvaqfhftewPdkdv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 163-305 1.5e-14 48.4 In-house 41-207 (301) alignment 
Range on Protein: 163-305
Range on HMM: 41-207/301.0
SWKNREGAGLPFDFNRVPLSKG----SMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLEWY
.  ||     ..| ||. |..     .. ..|||||..    .. ..| .| |.  | .|||..... ..  .|..   .|.      .|||.||  . .
kalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee

EEDITVTLTDRDEFKN-----I-----KASN-------LEIESDMneSHQALTMFQISNWPSDGTTPND
.  .||||..   . .     .     ..||       ....||.  | . .. .|. .|| ||  .. 
fgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvrep
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 161-301 1.7e-14 48.6 In-house 2-148 (237) alignment 
Range on Protein: 161-301
Range on HMM: 2-148/237.0
NNSWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCL-GRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPLEWYE
.|  ||| |    .| .|| |     |  ||||...  . |   .|| .| ||  .  |||.|. . .  |.|.|  . | .     .|||...  . | 
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

eDITVTLTDRDEFKNIKASNLEIESDMNESH-QALTMFQISNWPSDGT
  .||.|. ..|| .     | .   ..  . . .  .|.. ||  | 
.vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 150-301 2.5e-14 48.2 In-house 36-193 (325) alignment 
Range on Protein: 150-301
Range on HMM: 36-193/325.0
DPSVMKDAFNPNNSWKNREGAGLPFDFNRVPLS-KGSMG-NTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE----Y
|.  .| |  |.|  |||    ...| .|| |  |.  .   |||||..    .   .. .| ||..|  |.|...|. .  |.|||  ......    |
dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavy

WPDSEPLEWYEEDITVTLTDRDEFKNIKASNLEIESDMNESHQALTMFQISNWPSDGT
||.          . | |   .|. .     |..    .   ...  ||.  |.  |.
wpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGv
subfamily_PTPRB_pd Subfamily PTPRB 67-144 2.7e-14 47.9 In-house 11-91 (293) alignment 
Range on Protein: 67-144
Range on HMM: 11-91/293.0
ALEYEVSRLQD--EEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGSQ
 .|  |....   .   .||.  |..  ..  .. | |..|..|||| ||||.|..|| | . ....||||||||||.| .
kfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn
0047943 (Phosphotyrosine protein) phosphatases II 73-142 3.5e-14 48.4 In-house 6-72 (273) alignment 
Range on Protein: 73-142
Range on HMM: 6-72/273.0
SRLQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILsssKKEGSDYINANYIQG
 .| .  . .|||  | . . ..  . |.| .| .|||| .|||.| .||.|   . .|||||||.|..|
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdg
DSPc_SM00195 84-143 4.4e-14 47.8 In-house 5-65 (263) alignment 
Range on Protein: 84-143
Range on HMM: 5-65/263.0
EFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGS
||  | . | .   |.|  ..| .|||| ||||.|.|||.|....| |||||||||||.|.
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga
PTPc_SM00194 84-143 4.4e-14 47.8 In-house 5-65 (263) alignment 
Range on Protein: 84-143
Range on HMM: 5-65/263.0
EFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGS
||  | . | .   |.|  ..| .|||| ||||.|.|||.|....| |||||||||||.|.
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga
0046845 (Phosphotyrosine protein) phosphatases II 91-143 5.1e-14 47.8 In-house 12-68 (284) alignment 
Range on Protein: 91-143
Range on HMM: 12-68/284.0
HTREF--LQTNAVLSANATKNRYINILPFDETRVILSSSKK--EGSDYINANYIQGS
 |  .    . |.| .| .|||| .|||.| .||.|.| ..  |.||||||.|..| 
ltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgy
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 81-144 8.7e-14 46.2 In-house 23-87 (288) alignment 
Range on Protein: 81-144
Range on HMM: 23-87/288.0
AKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSS-SKKEGSDYINANYIQGSQ
 .||.  |.   ..  .| . |. ||.|||| ||||.||.|| |    ...|.|||||.||.|..
fseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgek
I-set Immunoglobulin I-set domain 600-691 1.1e-13 42.8 Pfam-A 3-90 (90) alignment 
Range on Protein: 600-691
Range on HMM: 3-90/90.0
LTITPTSLSVNHSDTATFTCTVTSLTTPNITWTTTaTAGITSQPNVLASSQGsdmHTSSLVLTGVILDSIGSYTCTATNEGGSIDTTAMLNV
.|...... |.  ......|||.   .|...|..     ..|. .|  . ..    ...|... |  .  |.|||.|||. |.  ..| |.|
ftqklkdvevseGesvelectveGepepsvsWakd.gselkssqrvkvtvee...aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
0045450 (Phosphotyrosine protein) phosphatases II 68-140 1.4e-13 46.7 In-house 16-92 (307) alignment 
Range on Protein: 68-140
Range on HMM: 16-92/307.0
LEYEVSRLQDEEVAKEEFVGLSDHTR--EFLQTNAVLSANATKNRYINILPFDETRVILSSSKK--EGSDYINANYI
|.. .  | . .  ..||  | . |    .  . | | .| .|||| .|||.| |||.||| ..  |.||||||.|.
llvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyv
0039614 (Phosphotyrosine protein) phosphatases II 66-145 2e-13 46.0 In-house 19-98 (297) alignment 
Range on Protein: 66-145
Range on HMM: 19-98/297.0
TALEYEVSRLQDEEVAKEEFVGLSDHTREflQTNAVLSANATKNRYINILPFDETRVILSSSKK--EGSDYINANYIQGSQN
 .| . . .. .  . ..||  | . . .  .. | | .| .||||..|||.| .||.|.. ..  ..||||||.|..|   
ldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl
0041856 (Phosphotyrosine protein) phosphatases II 162-304 2e-13 45.8 In-house 1-95 (182) alignment 
Range on Protein: 162-304
Range on HMM: 1-95/182.0
NSWKNREGAGLPFDFNRvplskgsmGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGsveeEDEYWPDSEplewyeeditvtl
|  |||    ||.|..|        ...||||... .  .. ..|.||.|| .|  ||..|. |......| |     |. |||. .             
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywpell.............

tdrdefknikasnleiesdmnesHQALTMFQISNWPSDGTTPN
                       ... . ..  .|| .|... 
.......................erlgiqylylpwpDhgvpdl
0036941 (Phosphotyrosine protein) phosphatases II 81-144 2.2e-13 45.6 In-house 15-75 (297) alignment 
Range on Protein: 81-144
Range on HMM: 15-75/297.0
AKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILsssKKEGSDYINANYIQGSQ
 ..||  | ..   .  . | | .| .|||| .|||.| |||.|   ..||||||||.|..| .
llkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgyd
0040438 (Phosphotyrosine protein) phosphatases II 79-144 2.9e-13 45.2 In-house 18-83 (317) alignment 
Range on Protein: 79-144
Range on HMM: 18-83/317.0
EVAKEEFVGLSDHTREfLQTNAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGSQ
 . .|||  | . . .   . | | .|  |||| .|||.| .||.||. .. ..||||||.|..| .
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpn
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 95-144 6.8e-13 43.0 In-house 28-77 (287) alignment 
Range on Protein: 95-144
Range on HMM: 28-77/287.0
FLQTNAVLSANATKNRYINILPFDETRVILSSSKKEGSDYINANYIQGSQ
..  .|   |.. |||| ..||.|.|||.||   . |||||||||. . .
atfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasyt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 77-144 9.5e-13 42.9 In-house 21-88 (319) alignment 
Range on Protein: 77-144
Range on HMM: 21-88/319.0
DEEVAKEEFVGLSDHTREfLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQ
 |   ..||  |.  . .   ..|    | .|||| |||..| |||.||.   .||||||||..|.| |
getllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 164-300 1e-12 42.2 In-house 50-188 (439) alignment 
Range on Protein: 164-300
Range on HMM: 50-188/439.0
WKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDEYWPDSEplEWYEEDITVTL
 |||     .||. || |    |     |||| ..        || || |  .|. |||....|...  .|.|  . |   ||| ..  | .  ||.|  
tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesykywpsda..evcygdiavrv

TDRDEFKNI--KASNLEIESDMNESHQALTMFQISNWPSDG
    |. |   .  ..  | | .|  ...  |.   ||   
drnielpnyvirgfkvfnerdttekertvlqfhyiawpdkn
subfamily_PTPN12_pd Subfamily PTPN12 94-145 1.3e-12 42.2 In-house 29-81 (290) alignment 
Range on Protein: 94-145
Range on HMM: 29-81/290.0
EFLQTNAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGSQN
.. ....  . | .|||| .|||.|..|| ||  .. |||||||||.|.|...
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 62-146 1.5e-12 42.3 In-house 9-94 (297) alignment 
Range on Protein: 62-146
Range on HMM: 9-94/297.0
PVELTALEYEVSRLQDEEVAKEEFVGLsDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKE-GSDYINANYIQGSQN-I
|. |. .   | . .. .| .|||  |  ..  . || |    |  |.|| ||||.|  ||.| .  ..  |||.|| ...| .. .
piplsdfatlvqknrhtdvfseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrl
0043336 (Phosphotyrosine protein) phosphatases II 79-144 1.7e-12 42.8 In-house 20-85 (278) alignment 
Range on Protein: 79-144
Range on HMM: 20-85/278.0
EVAKEEFVGLSDHTReFLQTNAVLSANATKNRYINILPFDETRVILSS-SKKEGSDYINANYIQGSQ
 . ..||  | . .  . .. | | .| .|||| .|||.| .||.||. .. ..||||||.|. | .
tllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgyn
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 163-301 2.1e-12 41.5 In-house 34-179 (297) alignment 
Range on Protein: 163-301
Range on HMM: 34-179/297.0
SWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTA--EYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPLEWYEE
  |||    | .| .|| | ..  .. |||| .|      |   |||.| || .|  |||... |. |.|.|..  ..|.       |||...       
lrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkag

DITVTLT--DRDEFKNIKASNLEIESDmNEShQALTMFQISNWPSDGT
|. |       |||.... ..|..    .|| . ..  |  .||  | 
dvvveflsstsdefdrviltelqliyr.ses.rvvrhvqflswpdhGv
subfamily_Ptp69D_pd Subfamily Ptp69D 69-145 2.5e-12 41.5 In-house 12-89 (307) alignment 
Range on Protein: 69-145
Range on HMM: 12-89/307.0
EYEVSRLQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQN
...... . ..  ..|.  |  .. .   ...    || |||| .| .||.|||.|.    || ||||||..|.| ..
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyke
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 106-241 2.6e-12 40.8 In-house 49-150 (349) alignment 
Range on Protein: 106-241
Range on HMM: 49-150/349.0
ATKNRYINILPFDETRVILSSSKKEgSDYINANYIQGSqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskGSMGNTYINASFVG--CLGRTA
 .|||| .|||.. .||.|  | |  |  |.|   .                                          ... . |||| ..    .    
faknrykdilPyehsrvklkkslks.skvikastsesd........................................sgklddyinanylkltrisvek

EYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----D
 || || ||  |  ||.|..|   |.... | . .|.     |
kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd
subfamily_PTPRA_pd Subfamily PTPRA 59-144 3.6e-12 40.8 In-house 10-98 (330) alignment 
Range on Protein: 59-144
Range on HMM: 10-98/330.0
KLSPVELTALEYEVSR--LQDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSK-KEGSDYINANYIQGSQ
|  |. .  || |. .   .| .  .|||  |   . .     |    |  |||..||||.| .|||||  . .| |||||| .|.| .
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk
I-set Immunoglobulin I-set domain 408-499 4.1e-12 37.7 Pfam-A 3-90 (90) alignment 
Range on Protein: 408-499
Range on HMM: 3-90/90.0
ISISPPSPSVEYNNSTTITCQVTSLTTPNITWTTTaTAGITSQPVVLASSQGsdvYTSSLVLTGVTLDSIGSYTCTATNQGGSSNTTAMLNV
... . .  |. ..| ...|.|.   .|...|..     ..|.  |  . ..    ...|... |. .  |.|||.|||. |.....| |.|
ftqklkdvevseGesvelectveGepepsvsWakd.gselkssqrvkvtvee...aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 84-145 1.4e-11 39.2 In-house 32-97 (298) alignment 
Range on Protein: 84-145
Range on HMM: 32-97/298.0
EFVGLSDHTR---EFLQTNAVLSANATKNRYINILPFDETRVILSS-SKKEGSDYINANYIQGSQN
||  |.  .    |. .. |  ..|  |||| .|...| .||.|.. ...| |||||| .... ..
efqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykg
I-set Immunoglobulin I-set domain 702-787 1.5e-11 35.9 Pfam-A 7-90 (90) alignment 
Range on Protein: 702-787
Range on HMM: 7-90/90.0
PPTLEIYYNTTLKLNCTVFSVTTPTINWTTTaNITIPIENIVTMNTGNmYKSVLTIDNVDLNYTGLYTCSSTNQGGTESDVSNVTV
.  .|.  .....|.|||  . .|...|..  .  .  .. |...  .  .. |||.||. . .| |||  ||. |...   ...|
lkdvevseGesvelectveGepepsvsWakd.gselkssqrvkvtvee.aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 97-145 1.6e-11 39.1 In-house 53-102 (319) alignment 
Range on Protein: 97-145
Range on HMM: 53-102/319.0
QTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQN
|| | |  |  |||.||||.||...| |     .|.|||||| ...| |.
qtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 97-145 2.7e-11 38.5 In-house 17-66 (284) alignment 
Range on Protein: 97-145
Range on HMM: 17-66/284.0
QTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQN
|| | |  |  |||...||.||...| |     .|.|||||| .|.| |.
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqr
subfamily_CG42327_pd Subfamily CG42327 187-309 3e-11 37.5 In-house 55-184 (319) alignment 
Range on Protein: 187-309
Range on HMM: 55-184/319.0
GNTYINASFV-GCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----EYWPDSEPLEWYE--EDITVTLTDRDEFKNIKASNLEIE
 . |..||.| |     . || .| .| |.| |||... |.   |.| | .. |       ||.| .| |.  .   || ||| .|.  ..   | | . 
kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllk

SDMNESHQALTMFQIsNWPSDGTTPNDHFIM
   .|  . || .   .|.  .   ..  ..
rvdkeesrelthywy.kwleaevPaeeaali
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 79-143 3.7e-11 37.7 In-house 15-80 (281) alignment 
Range on Protein: 79-143
Range on HMM: 15-80/281.0
EVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILS-SSKKEGSDYINANYIQGS
.  .||. .|..  ..   | .   .| .||||.||  .| ||| .. ..... .||||||...| 
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgy
subfamily_PTPN3_pd Subfamily PTPN3 95-141 6.2e-11 36.7 In-house 31-74 (280) alignment 
Range on Protein: 95-141
Range on HMM: 31-74/280.0
FLQTNAVLSANATKNRYINILPFDETRVILSSSKKegsDYINANYIQ
   ..| ...|..|||| .|||.|.|||.|..|..   |||||||..
laisaarkpenlsknryrdilpydatrvklkeset...dyinanyvn
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 96-145 1.5e-10 35.7 In-house 19-70 (274) alignment 
Range on Protein: 96-145
Range on HMM: 19-70/274.0
LQTNAVLSANATKNRYINILPFDETRVILS--SSKKEGSDYINANYIQGSQN
 | .  .. ..||||| .||| ...||.|.  ||..| |.|||||||.| ..
dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGyde
subfamily_PTPN9_pd Subfamily PTPN9 83-144 1.7e-10 35.4 In-house 20-82 (297) alignment 
Range on Protein: 83-144
Range on HMM: 20-82/297.0
EEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINANYIQGSQ
.|.. . ... |   ... | || .|||| ..| .||||| |..  ..| |||||||...| .
keyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 191-309 1.8e-10 35.0 In-house 78-203 (301) alignment 
Range on Protein: 191-309
Range on HMM: 78-203/301.0
INASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPDSEPLEWYEEDITVTLTDRDEF--KNIKASNLEIESDMNE
| | ..   |..  .| || || .|| ||| |.   .|. .|.||   |.     .|| | . . .   .  ........    |.|.  .||.|   ..
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

-SHQALTMFQISNWPSDGtTPNDHFIM
 . ...| .| |.|.  | .|. |  .
fatrtvthyqysewtdrg.vPkshael
subfamily_egg_pd Subfamily egg 153-248 2.1e-10 34.8 In-house 31-131 (307) alignment 
Range on Protein: 153-248
Range on HMM: 31-131/307.0
VMKDAFNPNNSWKNREGAGLPFDFNRVPL--SKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED---EYWPDS
 .. |.. ||  | |.      |. || |   .|   . .| |  |       |.||.| || .|  |||.|. . .|. .|.| |  | .    ||| .
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpka

E
|
e
0049772 (Phosphotyrosine protein) phosphatases II 160-304 2.1e-10 36.3 In-house 44-195 (314) alignment 
Range on Protein: 160-304
Range on HMM: 44-195/314.0
PNNSWKNREGAGLPFDfNRVPLSKGSM-GNTYINASFVGCLgrtAEYILTQHPLADTSMDF----------WKMMLERHVNVLVVLG-------------
. |  |||    ||.| ||| |.. .. |  |||||.| .      .| ||.||  |  ||          |.|.|.   || .. .             
flnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------SVEEEDEYwpdSEPLEWYEEDITvtltdrdefknikasnlEIESDMNESHQA-LTMFQIsNWPSdGTTPN
          .    .   .|| ... |..                  |.  | .   .. .. ..| ..|  |..| 
daAlgKtpllildgng...neptaadlellk.................eelydpelferlgikylri.pvpD.gsapl
subfamily_ptpA1_pd Subfamily ptpA1 82-143 2.2e-10 34.8 In-house 24-86 (418) alignment 
Range on Protein: 82-143
Range on HMM: 24-86/418.0
KEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSS-SKKEGSDYINANYIQGS
||||  | .       ..     |..|||| |||| . ||| |     ||||||||||||.|.
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga
0045098 (Phosphotyrosine protein) phosphatases II 98-143 2.4e-10 35.7 In-house 26-62 (278) alignment 
Range on Protein: 98-143
Range on HMM: 26-62/278.0
TNAVLSANATKNRYINILPFDETRVIlssskkegsDYINANYIQGS
|.|..  |. |||| .|||.| .||.         |||||.||.| 
tpalylgnldknRykdilpydhsrVk.........dYINAsyidgy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 73-142 2.5e-10 35.0 In-house 17-86 (325) alignment 
Range on Protein: 73-142
Range on HMM: 17-86/325.0
SRLQDEEVAKEEFvGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKEG-SDYINANYIQG
 . ||..    || ||        .. |.. .|  |||. |....|..||.| . |... ||||||.|.. 
kkaqdqdgfahef.gllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrd
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 151-303 2.5e-10 34.9 In-house 30-193 (307) alignment 
Range on Protein: 151-303
Range on HMM: 30-193/307.0
PS-VMKDAFNPNnSWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYW
|  |  .||. | . |||       | .|. .    .   || | ..|   .   .| .| || .|  .|| |... .|. ...|  | |      ..||
pegvtveafsan.tdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqyw

PDSEP--LEWYEEDITVTLTDRDEF------KNIKASNLEIesDMNESHQALTMFQISNWPSDGTTP
|  |   | . |.  |.....          . |. ..|..  |  .  .... .| .|||  |. .
pleegqklvfgeapntisvanlgakklapdedlinvttlkv..dwaqksrtiqhlqwenwpdrgvpq
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 151-243 3.2e-10 34.1 In-house 37-123 (303) alignment 
Range on Protein: 151-243
Range on HMM: 37-123/303.0
PSVMKDAFNpNNSWKNREGAGLPFDFNRVPLSKGSmgntYINASFVGcLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDEY
||| |. |  .|  |||    . .|  .| ||  |    || ||..  |  .   |||| ||. |. |||.|..|..|.....| .  | |..
psvsknqfv.knmdknrfvdvicldhskvklsdss....yihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydkl
Ig_3 Immunoglobulin domain 411-486 3.4e-10 32.0 Pfam-A 7-75 (75) alignment 
Range on Protein: 411-486
Range on HMM: 7-75/75.0
SPPSPS-VEYNnsTTITCQVTSLT-TPNITWTttatagiTSQPVVLASSQGSDVYTSSLVLTGVTLDSIGSYTCTATN
||..   .. |   |.||....   .|.|.|.        ..| .| .|.||. . |.|....|| .  |.|||.|.|
spsptvtsggn..vtLtCsaeggpppptisWy.......ietppelqgsegssssestLtissvtsedsGtYtCvasN
0037934 (Phosphotyrosine protein) phosphatases II 100-148 3.6e-10 35.3 In-house 5-48 (243) alignment 
Range on Protein: 100-148
Range on HMM: 5-48/243.0
AVLSANATKNRYINILPFDETRVILssskkEGSDYINANYIQGSQNIIR
| | .| .|||| .|||.| .||.|     |||||||||.|..  ..|.
allpenlsknrysdilpydhsrvkl.....egsdyinanliyvtprlia
Ig_2 Immunoglobulin domain 410-501 4.4e-10 31.5 Pfam-A 4-80 (80) alignment 
Range on Protein: 410-501
Range on HMM: 4-80/80.0
ISPPSPSVEYNNSTTITCQVTSLTTPNITWTTTAtAGITSQPVVlassqgsdVYTSSlvltgVTLDSIGSYTCTATNQGGsSNTTAMLNVTV
.|.|...|. . . |.|||...  ||...|.    . .....          .....     |...  |.|||.|.|..| |... ...|||
lsapptvvtegenvtLtCqapgnptpkvqwykdg.eelsqsqna........lfipn.....vsaedsGtYtCrasnseg.skqsnsvevtv
0042113 (Phosphotyrosine protein) phosphatases II 101-144 4.8e-10 34.7 In-house 5-49 (245) alignment 
Range on Protein: 101-144
Range on HMM: 5-49/245.0
VLSANATKNRYINILPFDETRVILSSSKKE-GSDYINANYIQGSQ
 | .| .|||| .|||.| |||.||. . . .||||||.|. |..
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyr
Y_phosphatase Protein-tyrosine phosphatase 105-145 4.9e-10 34.6 Pfam-A 1-40 (235) alignment 
Range on Protein: 105-145
Range on HMM: 1-40/235.0
NATKNRYINILPFDETRVILsSSKKEGSDYINANYIQGSQN
| .|||| .|||.|.||| | ..... ||||||||..| ..
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyke
Y_phosphatase Protein-tyrosine phosphatase 105-145 4.9e-10 34.6 In-house 1-40 (235) alignment 
Range on Protein: 105-145
Range on HMM: 1-40/235.0
NATKNRYINILPFDETRVILsSSKKEGSDYINANYIQGSQN
| .|||| .|||.|.||| | ..... ||||||||..| ..
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyke
subfamily_PTPRG_pd Subfamily PTPRG 100-144 5e-10 33.2 In-house 42-88 (563) alignment 
Range on Protein: 100-144
Range on HMM: 42-88/563.0
AVLSANATKNRYINILPFDETRVILSSSK-KEGS-DYINANYIQGSQ
.    |  ||||.||...|..|| ||.   |... ||||||||.| |
sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq
Ig_2 Immunoglobulin domain 512-592 5.8e-10 31.1 Pfam-A 8-80 (80) alignment 
Range on Protein: 512-592
Range on HMM: 8-80/80.0
NVTITYGMNLTLDCTVSsVFLPLTVEWRFGQMVIKtmnytS---AptgplqVSVTSVTGSNAGVYTCVATHDH-GTDSDNVNVIV
....| | |.|| |...  . . .| |. .   ..     .   |      . . .|. ...|.|||.|. .. .. |. |.| |
ptvvtegenvtLtCqap.gnptpkvqwykdgeels.....qsqna......lfipnvsaedsGtYtCrasnsegskqsnsvevtv
0040439 (Phosphotyrosine protein) phosphatases II 100-143 9.2e-10 34.0 In-house 6-50 (249) alignment 
Range on Protein: 100-143
Range on HMM: 6-50/249.0
AVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGS
| | .|  |||| .|||.| .||.||. .. ..||||||.|| |.
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgy
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 80-144 1.1e-09 32.6 In-house 20-84 (315) alignment 
Range on Protein: 80-144
Range on HMM: 20-84/315.0
VAKEEFVGLSDHTrEFLQTNAVLSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGSQ
.  |||  | |    . |. |  . | .|||| ||||.|..||.|    ..  |||||| ||.. .
lfseefhdlpdPd.iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 82-145 1.1e-09 32.0 In-house 21-84 (515) alignment 
Range on Protein: 82-145
Range on HMM: 21-84/515.0
KEEFVGLSDhTREFLQTNAVLSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGSQN
 |||  |      . || |    | .|||| ||||.| .||.|     .  |||.|| ||.. .|
seefhdlpg.pniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 159-308 1.1e-09 32.5 In-house 45-208 (305) alignment 
Range on Protein: 159-308
Range on HMM: 45-208/305.0
NPNNSWKNREGAGLPFDFNRVPLsKGSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWP--DSEPLE
. ... |||      .| ||| | .|.    || | .|     .  .| || || .|  ||| | |. .|. . .|  . |       ||..  | . ||
eaqeagknrykdvgcldnnrvkl.egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

WYEED--ITVTLTDRDE--F-----KNIKASNLEIESDMnESHQALTMFQISNWPSDGTTPNDHFI
. |..  |.| .    .  |      ..... | ||    |. .  | .   .||  |  . |  |
feekgqkisvkfessvtlkfrkdakakvtetvlviegpg.ekarkvthyhwidwpdrgvpaadlai
subfamily_PTPN13_pd Subfamily PTPN13 77-141 1.3e-09 32.8 In-house 9-69 (273) alignment 
Range on Protein: 77-141
Range on HMM: 9-69/273.0
DEEVAKEEFVGLSDhTREFLQTNAVLS-ANATKNRYINILPFDETRVILSSSKKegsdYINANYIQ
|..  .|||  | .  .  ....   . .| .|||| |.||.|||||.|...      ||||..|.
dqqqPaeefkelre.lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslik
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 103-144 1.7e-09 32.3 In-house 7-49 (250) alignment 
Range on Protein: 103-144
Range on HMM: 7-49/250.0
SANATKNRYINILPFDETRVILSSSK-KEGSDYINANYIQGSQ
 .|  |||| .|...|..||.| ..|  . |||||| ...| .
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyd
0051429 (Phosphotyrosine protein) phosphatases II 188-303 2e-09 33.0 In-house 4-137 (272) alignment 
Range on Protein: 188-303
Range on HMM: 4-137/272.0
NTYINASFVGCLGR---TAEYILTQHPLADTSMDFWKMmLERHVNVLVVLGSVEEE-----DEYWP----------DSEPLEWYEEDITVTLTDRDEFKN
..||||..|| .||      ......||  |  |||..  | .... | | |.||      | |||          |... .    ...|||.    . .
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

IKASNLEIESD-MNESHQALTMFQISNWPSDGTTP
.   .|...    ..    .....  .|| .|. .
yilrellltlllsagearevmhlhytdwpdhgvpq
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 98-143 2.1e-09 31.5 In-house 41-84 (95) alignment 
Range on Protein: 98-143
Range on HMM: 41-84/95.0
TNAVLSANATKNRYINILPFDETRVILSSskKEGSDYINANYIQGS
|     ||  |||..||.|.| |||.|..  |  |||||| ...| 
tvgsseanipknrflnifpydatrvvltt..krdsdyinacfvdgy
0049772 (Phosphotyrosine protein) phosphatases II 98-148 3.1e-09 32.5 In-house 39-88 (314) alignment 
Range on Protein: 98-148
Range on HMM: 39-88/314.0
TNAVLSANATKNRYINILPFDeTRVILSSSKKEGSDYINANYIQGSQNIIR
. | | .| .||||..|||.| .||||..   .|||||||.|. | .. |.
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgflkfIa
subfamily_ptpA1_pd Subfamily ptpA1 157-246 4.8e-09 30.4 In-house 42-137 (418) alignment 
Range on Protein: 157-246
Range on HMM: 42-137/418.0
AFNPNNSWKNREGAGLPFDFNRVPLSK--GSMGNTYINASFVGCLgRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE-----DEYWPD
  .  |. |||    || .. || | |     |. |||| ..       ..| || || .|  |||.|. | .. ..|.|    |.     | |||.
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpe
Ig_3 Immunoglobulin domain 606-678 4.8e-09 28.3 Pfam-A 10-75 (75) alignment 
Range on Protein: 606-678
Range on HMM: 10-75/75.0
SLSVNH-SdtATFTCTVTSLT-TPNITWTttatagiTSQPNVLASSQGSDMHTSSLVLTGVILDSIGSYTCTATN
.  ..  .   |.||....   .|.|.|.        ..|..| .|.||.   |.|....|  .  |.|||.|.|
ptvtsggn..vtLtCsaeggpppptisWy.......ietppelqgsegssssestLtissvtsedsGtYtCvasN
I-set Immunoglobulin I-set domain 804-886 4.9e-09 27.9 Pfam-A 12-89 (90) alignment 
Range on Protein: 804-886
Range on HMM: 12-89/90.0
VTYADTLSIMCNVTSLMRPsSIVWYHNDTLISSGAQPNFTATGapntYTSVLVRDNVVLRDNGVYRCQAENMAGIGAANINIS
|.  ..... |.|.    | |. |..... ..|  . ..|...     .. |. .||  .|.| |.|.|.| ||   |.....
vseGesvelectveGepep.svsWakdgselkssqrvkvtvee....aeytLtIsnvevsDeGkYtckatnsagkaeakaeLk
I-set Immunoglobulin I-set domain 504-592 5.2e-09 27.8 Pfam-A 1-90 (90) alignment 
Range on Protein: 504-592
Range on HMM: 1-90/90.0
PSVSIPDDNVTITYGMNLTLDCTVSSVfLPLTVEWRFGQMVIKT---MNYTSAPtGPLQVSVTSVTGSNAGVYTCVATHDHGTDSDNVNVIV
|..... ..|... | ...|.|||. .  ...|.|  ..  .|.   ...|    .  .  ...|. |..| |||.||   |... .... |
pkftqklkdvevseGesvelectveGe.pepsvsWakdgselkssqrvkvtvee.aeytLtIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_PTPN14_pd Subfamily PTPN14 75-141 6.7e-09 30.1 In-house 20-85 (300) alignment 
Range on Protein: 75-141
Range on HMM: 20-85/300.0
LQDEEVAkEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKEGSDYINANYIQ
|.. .|   |.  .. .  . | . | |  || |||. ..||....|| ||..|.. ..||||  |.
leegkvf.teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassik
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 81-145 9e-09 29.2 In-house 22-86 (392) alignment 
Range on Protein: 81-145
Range on HMM: 22-86/392.0
AKEEFVGLSDHTrEFLQTNAVLSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGSQN
  |||  | .    . || |    |  |||| ||||.|..||.|        |||.|| ||.. .|
ffeefhdlpgpd.iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdn
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 82-144 9e-09 29.7 In-house 23-83 (287) alignment 
Range on Protein: 82-144
Range on HMM: 23-83/287.0
KEEFVGLSD-HTREFLQTNAVLSANATKNRYINILPFDETRVILSsskKEGSDYINANYIQGSQ
|. |. | .   ||   | .. | |  |||. .||. |. ||.|    .|  ||||| .|.| .
knqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgyk
subfamily_eak_pd Subfamily eak 172-307 1.2e-08 28.8 In-house 61-200 (332) alignment 
Range on Protein: 172-307
Range on HMM: 61-200/332.0
LPFDFNRVPLSKGSMG-NTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLG-----SVEEEDEYWPDSEPLEWYEEDITVTLTDRD
.|.|.. | |.   .  . ||||| .       .||||  .  |  . ||.|.||..   .| |       .|. | |.||    |.    . |.  .  
vpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefv

EFKNIKASNLEIeSDMNESHQALtMFQISNWPSDGTTPNDHF
. ....  .||. |  ||.|. |  ...  |    .   . |
krniletrllel.skGnethrvl.hykvfGwtettlpkyedf
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 102-143 1.3e-08 29.1 In-house 46-88 (315) alignment 
Range on Protein: 102-143
Range on HMM: 46-88/315.0
LSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGS
 . |  |||||||...|..|| |    ....|||.|||.|.| 
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGy
Ig_2 Immunoglobulin domain 601-693 1.4e-08 26.7 Pfam-A 3-80 (80) alignment 
Range on Protein: 601-693
Range on HMM: 3-80/80.0
TITPTSLSVNHSDTATFTCTVTSLTTPNITWTTtATAGITSQPNVlassqgsdMHTSSlvltgVILDSIGSYTCTATNEGGSIDTTAMlNVTV
...... .|. ... |.||....  ||...|.   .. .....|         .....     | ..  |.|||.|.|..||. .. . .|||
vlsapptvvtegenvtLtCqapgnptpkvqwyk.dgeelsqsqna........lfipn.....vsaedsGtYtCrasnsegskqsnsv.evtv
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 94-301 1.5e-08 27.8 In-house 16-154 (169) alignment 
Range on Protein: 94-301
Range on HMM: 16-154/169.0
EFLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINAnyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyin
|. .  | |..| ||||    |    ||| |    .. |||||||                                                       
eynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina.......................................................

asfvgclgrtaeyiltqhpladtsmdfwKMMLERHVNVLVVLGSVEEEDEYWPDSEPL---------EWYEEDITVTlTDRDEFKN-----IKASNLEIE
                            .|. |    |.||||  .. ...||. |           ||| . . |  ||. . .      .   .. | 
............................rmiwetnasvivvlgdtddknnfwpekedyqlhpavilgewytdslyvr.tdkvhantsgveglfevsmvih

SDMNESHQALTMFQISNWPSDGT
|  ..  . |.... | || .| 
sydddvteklsllhystwpqngv
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 162-269 1.5e-08 29.1 In-house 8-120 (239) alignment 
Range on Protein: 162-269
Range on HMM: 8-120/239.0
NSWKNREGAGLPFDFNRVPLSKGSMG--NTYINASFVGC-LGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLG-SVEE----EDEYWPDSEPleWY
|  |||    . .|..|| | | |    . |||||..    |    || ||  .. .| |||.|| . .  |.|.|   .|       .|||||     |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..ky

eEDITVTLTDRDEFKN
  .. |||   . | .
.cnlrvtlrktevfad
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 162-269 1.7e-08 28.9 In-house 7-119 (239) alignment 
Range on Protein: 162-269
Range on HMM: 7-119/239.0
NSWKNREGAGLPFDFNRVPLSKGSMG--NTYINASFVGC-LGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLG-SVEE----EDEYWPDSEPleWY
|  |||    . .|..|| | | |    . |||||..    |    || ||  .. .| |||.|| . .  |.|.|   .|       .|||||     |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..ky

eEDITVTLTDRDEFKN
  .. |||   . | .
.cnlrvtlrktevfad
I-set Immunoglobulin I-set domain 311-388 1.7e-08 26.1 Pfam-A 4-80 (90) alignment 
Range on Protein: 311-388
Range on HMM: 4-80/90.0
EVTPDDPTVTYGSDVTLTCSHDDTinaANLTIEWTTTASNTDL-SSVAMTSDT-SSTLTLSNVDLSRTGTYTCDVDDDDG
. ...| .|. |..|.|.|.   .    .....|..  |..   ..| .| .  ..|||.|||. | .|.||| .    |
tqklkdvevseGesvelectveGe...pepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsag
Ig_3 Immunoglobulin domain 316-381 1.7e-08 26.6 Pfam-A 9-71 (75) alignment 
Range on Protein: 316-381
Range on HMM: 9-71/75.0
DPTVTYGSDVTLTCSHDDTINaaNLTIEWTtTASNTDLSSVAMTSDTSSTLTLSNVDLSRTGTYTC
 |||| |  |||||| ...    . || |.    .  |...  .|...||||.|.|. . .|||||
sptvtsggnvtLtCsaeggpp..pptisWy.ietppelqgsegssssestLtissvtsedsGtYtC
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 104-145 1.8e-08 28.7 In-house 19-61 (270) alignment 
Range on Protein: 104-145
Range on HMM: 19-61/270.0
ANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGSQN
 ... ||| .|||  .|||.|.. .. . . ||||||..| ..
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdg
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 94-301 1.9e-08 27.3 In-house 15-153 (169) alignment 
Range on Protein: 94-301
Range on HMM: 15-153/169.0
EFLQTNAVLSANATKNRYINILPFDETRVILSSS-KKEGSDYINAnyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyin
|. .  | |..| ||||    |    ||| |    .. |||||||                                                       
eynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina.......................................................

asfvgclgrtaeyiltqhpladtsmdfwKMMLERHVNVLVVLGSVEEEDEYWPDSEPL---------EWYEEDITVTlTDRDE-----FKNIKASNLEIE
                            .|. |    |.||||  .. ...||. |           ||| . . |  ||. .      . .    | |.
............................rmiwetnasvivvlGdtddknnfwpekedyqlhpavilGewytdslyvr.tdkvhpntsgveglfevslvih

SDMNESHQALTMFQISNWPSDGT
|  ..  . |.... | || .| 
sydddvteqlsllhystwpqngv
0043147 (Phosphotyrosine protein) phosphatases II 187-307 2.2e-08 29.5 In-house 4-84 (172) alignment 
Range on Protein: 187-307
Range on HMM: 4-84/172.0
GNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVeeedeywpdseplewyeeditvtltdrdefknikasnleiESDMNESHQ
|..|||||.. .   . ..| || ||  |  |||.|. |......| | .                                         . |.   ..
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................lydpeller

ALTMFQISNWPSDGTTPNDHF
    ..  .||  |... ...
lgiqylylpwpDhgvpllell
Ig_2 Immunoglobulin domain 314-400 2.2e-08 26.0 Pfam-A 6-80 (80) alignment 
Range on Protein: 314-400
Range on HMM: 6-80/80.0
PDDPTVTYGSDVTLTCSHDdtiNAANLTIEWTTTASNTDlssvamtsD-TSStLTLSNVDLSRTGTYTCDVDDDDGtIEGTDSIVLTV
. ...|| |..|||||. .   . .. .. |.   . ..          ..  | ..|| ..  ||||| .  . |  . ..|. .||
apptvvtegenvtLtCqap...gnptpkvqwykdgeels........qsqna.lfipnvsaedsGtYtCrasnseg.skqsnsvevtv
Ig_2 Immunoglobulin domain 1111-1189 2.4e-08 25.9 Pfam-A 8-78 (80) alignment 
Range on Protein: 1111-1189
Range on HMM: 8-78/80.0
EenSTAILGDKFMFRCDPDySNPRPHLQISKiltNGTELNlyTGQSKLHSiMNVAFDDAGNYRCVLTNDY-GRTESNFQL
   ...  |... ..|  . .|| | .| .|   .|.||.  ..|..|..  ||  .|.|.|.|...|.  . . . ...
p..tvvtegenvtLtCqap.gnptpkvqwyk...dgeels..qsqnalfi.pnvsaedsGtYtCrasnsegskqsnsvev
Ig_2 Immunoglobulin domain 796-879 2.7e-08 25.7 Pfam-A 4-72 (80) alignment 
Range on Protein: 796-879
Range on HMM: 4-72/80.0
ITSSPmKYVTYADTLSIMCNVTsLMRPSSIVWYHNDTLISSGAQPnftatgapntytsVLVrDNVVLRDNGVYRCQAENMAG-IG
....|  .||  ... ..| ..    . .. ||......|..                ...  || . |.|.|.|.| |  | . 
lsapp.tvvtegenvtLtCqap.gnptpkvqwykdgeelsqsqna.............lfi.pnvsaedsGtYtCrasnsegskq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 149-253 2.8e-08 27.7 In-house 40-149 (310) alignment 
Range on Protein: 149-253
Range on HMM: 40-149/310.0
PDPSVMKDAFNpNNSWKNREGAGLPFDFNRVPLSK-GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEED-----E
 |.|.  .|.. ..  |||    .  |  || |    |  . || | .|      . .| .| ||  | .|||.|...   . ...|  | ||       
qdssltyeayk.kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvg

YWPDSEPLEWY
|||     | |
ywpslgvtety
subfamily_PTPN23_pd Subfamily PTPN23 97-142 3.9e-08 27.4 In-house 35-77 (288) alignment 
Range on Protein: 97-142
Range on HMM: 35-77/288.0
QTNAVLSANATKNRYINILPFDETRVILSsskKEGSDYINANYIQG
.. |.   ...|||. .|||.|..|| |    ..  ||||| ....
rsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkd
subfamily_PTPRK_pd Subfamily PTPRK 102-144 4.9e-08 27.1 In-house 40-83 (314) alignment 
Range on Protein: 102-144
Range on HMM: 40-83/314.0
LSANATKNRYINILPFDETRVILSSSKKE-GSDYINANYIQGSQ
   | .|||. .||..| .||.| . . .  ||||||..| . .
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk
Ig_3 Immunoglobulin domain 503-578 5e-08 25.0 Pfam-A 1-74 (75) alignment 
Range on Protein: 503-578
Range on HMM: 1-74/75.0
PPSVSIPDDNVTITYGMnLTLDCTVSSVFLPLTVEWR-FGQMVIKTMNYTSAPTGPLQVSvtSVTGSNAGVYTCVAT
.|..|..  ..... |  .|| |.. . . | |. |   . ..... ...|   . | .|  ||| .. |.|||||.
kPvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtis..svtsedsGtYtCvas
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 185-233 5.3e-08 26.8 In-house 67-115 (347) alignment 
Range on Protein: 185-233
Range on HMM: 67-115/347.0
SMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVV
   .|||||| .     . ||||||.|| ||  |||||.   .|  .| 
ddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
0036282 (Phosphotyrosine protein) phosphatases II 187-305 6.9e-08 27.9 In-house 1-86 (174) alignment 
Range on Protein: 187-305
Range on HMM: 1-86/174.0
GNTYINASFVGCLGRTAEYILTQHPLAdtsmdFWKMMLERHVNVLVVLGSVEEED-----EYWPDseplewyeeditvtltdrdefknikasnleiesDM
|..|||||...   .| ..|..|.|||     ||.|. | .....| | . .| .      |||.                                 ..
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

NESHQALTMFQISNWPSDGTTPND
.  ..    ..  .|| .|. . .
edlerlgiqylylpwpDhgvpdls
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 161-241 7e-08 26.3 In-house 33-114 (332) alignment 
Range on Protein: 161-241
Range on HMM: 33-114/332.0
NNSWKNREGAGLPFDFNRVPLSKGSMGNTYINASFVGCLGRTAEYILTQHPLAD-TSMDFWKMMLERHVNVLVVLGSVEEED
||   ||      ||..|| |.     . . |||.|    . . ||..| |. | |   ||.|. ||. ....|.| ..|..
nnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekq
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 76-145 8.8e-08 26.3 In-house 17-89 (290) alignment 
Range on Protein: 76-145
Range on HMM: 17-89/290.0
QDEEVAKEEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILS--SSKKE-GSDYINANYIQGSQN
. .|  ...|  |    .|.  | .. | | ..||. ||.. |. |..|   |..|.   .|||| ||.| ..
kgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 82-144 1.1e-07 26.2 In-house 19-79 (307) alignment 
Range on Protein: 82-144
Range on HMM: 19-79/307.0
KEEFVGLSDHTREFLQTNAvLSANATKNRYINILPFDETRVILSSSkKEGSDYINANYIQGSQ
..||  |...| | ....| .|||. |||| ..   | .|...  .    |||| |||.  . 
vdefrvlakktpegvtvea.fsantdknryqdvkcqdkgrivvkfd.glasdyihanylgiai
subfamily_PTPN1_pd Subfamily PTPN1 83-141 1.2e-07 25.7 In-house 10-65 (290) alignment 
Range on Protein: 83-141
Range on HMM: 10-65/290.0
EEFVGLSDHTREFLQTNAVLSANATKNRYINILPFDETRVILSSSKKegsDYINANYIQ
| .  .......| ...| | .| ..||| .. |.| .|..| ....   |||||. ..
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslve
0046846 (Phosphotyrosine protein) phosphatases II 184-307 1.4e-07 27.0 In-house 8-95 (176) alignment 
Range on Protein: 184-307
Range on HMM: 8-95/176.0
GSMGNTYINASFVGClgrtAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDEYWPDSEPLEWYEEDItvtltdrdefknikasnleiesdmne
  .. .||||... .    . .| ||.|| .| .||..|..| .....| | .  | . .. .  . |.....|                          
ldldldyinanlilg....srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

shqaltMFQISNWPSDGTTPNDHF
       ..  .||  |. . ...
......qylhlpwpDhgvpdlell
ig Immunoglobulin domain 322-383 1.9e-07 22.3 Pfam-A 1-64 (64) alignment 
Range on Protein: 322-383
Range on HMM: 1-64/64.0
GSDVTLTCSHddTINAANLTIEWTTTASNTDLSSVAMTSDTSST----LTLSNVDLSRTGTYTCDV
||.||||||.    .  . .. |.   . . .|.   .......    ||..||  .  ||||| |
GssvtLtCsv..ssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCvv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 155-240 2.2e-07 24.8 In-house 43-133 (305) alignment 
Range on Protein: 155-240
Range on HMM: 43-133/305.0
KDAFNPNNS-----WKNREGAGLPFDFNRVPLSKGSmGNTYINASFVGCLG-RTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE
. ||| |.|      |||       | . | |.| |    || | .|||       .| .| || .|  .|| |.....|. .|.|    | 
qvafnanqsadiaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvel
V-set Immunoglobulin V-set domain 310-393 3.5e-07 21.1 Pfam-A 4-108 (114) alignment 
Range on Protein: 310-393
Range on HMM: 4-108/114.0
VEVTPDDPTVTYGSDVTLTCSHDdTiNAANLTIEWTTTASNTDLSSVA--------------------MTSDTS---STLTLSNVDLSRTGTYTCDVDDD
|. .|   ||  | .|||.|.   . . .. .| |    ....   ..                    ..|..|    .||..|. |. .|||||.| | 
vsqsprpvtvaeGgsvtLpCfys.s.sensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsds

DGTIEGT
.. ..|.
nedvfga
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 149-277 5e-07 23.7 In-house 23-160 (281) alignment 
Range on Protein: 149-277
Range on HMM: 23-160/281.0
PDPSVMKDAFN-PNNSWKNREGAGLPFDFNRVPLSK---GSMGNTYINASFVGCLGRTAEYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEE----
  || .  .|| | |  |||      .|  || |           || | ..        ||||| |  .|  |||.|. .     .|.|  . |     
dppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrek

-DEYWPDSEPLEWYEEDITVTLTDRDEFKNIKASNLEI
  ||.|         . ..|.  |    | . .. |..
caeyfprnahcclqfdklsvsyedstvnkslvttrlnl
ig Immunoglobulin domain 518-577 5.6e-07 20.8 Pfam-A 1-64 (64) alignment 
Range on Protein: 518-577
Range on HMM: 1-64/64.0
GMNLTLDCTVSSVFLPLTVEWRFGQMVIKTMNYTSAPTGPLQ----VSVTSVTGSNAGVYTCVA
|...|| |.|||   . .| | ... . .. ..|   .   .    . ...|| ...|.||||.
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCvv
Ig_3 Immunoglobulin domain 710-774 5.8e-07 21.6 Pfam-A 17-75 (75) alignment 
Range on Protein: 710-774
Range on HMM: 17-75/75.0
NttLKLNCTVFSVT-TPTINWTttaniTIPIENIVTMNTGNMYKSVLTIDNVDLNYTGLYTCSSTN
|  ..|.|....   .||| |.       .  .. . .  . . |.||| .|. ...| |||  .|
n..vtLtCsaeggpppptisWy.....ietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 78-144 7.4e-07 23.6 In-house 21-86 (305) alignment 
Range on Protein: 78-144
Range on HMM: 21-86/305.0
EEVAKEEFVGLSDHtREFLQTNaVLSANATKNRYINILPFDETRVILSSSKKEG-SDYINANYIQGSQ
..  ....  | ..  | .. .   .||..|||. .| ..|. |.||. ..... ||||||.|..| .
dkgleaqykslyee.eesidvg.kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgyk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 99-145 7.7e-07 23.0 In-house 48-94 (290) alignment 
Range on Protein: 99-145
Range on HMM: 48-94/290.0
NAVLSANA--TKNRYINILPFDETRVILSSSKKegSDYINANYIQGSQN
  .. .|.  .|||| ..   | |||||.   .   ||. |||..| . 
rkifdkntefkknrykdvvcndktrvilkdGyd..GdyvhanyvkGlka
Ig_2 Immunoglobulin domain 700-787 8.7e-07 20.9 Pfam-A 4-80 (80) alignment 
Range on Protein: 700-787
Range on HMM: 4-80/80.0
LTPPTLEIYYNTTLKLNCTVFSVTTPTINWTTTANITIPIENIvtmntgnmyksvLTIDNVDLNYTGLYTCSSTN-QGGTESDVSNVTV
|..|  ..  .... |.|.. .  ||.. |.   ... . .|.            | | || ... | |||. .| .|.. |.  .|||
lsapptvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna............lfipnvsaedsGtYtCrasnsegskqsnsvevtv
fn3 Fibronectin type III domain 1197-1279 1e-06 21.9 Pfam-A 2-85 (85) alignment 
Range on Protein: 1197-1279
Range on HMM: 2-85/85.0
QVTGVTVTYLSFFEILFRWNVPSSNFGRDQRYNVEYRLLLAEA-SSSNITGLTDPSYLLTDVALNVNYSVVVSSNNEVGRGPPS
......|.  .  .. ..|. |... | ...|.||||    .  . .  .  | .|. ||.   . .|.. | . |..| ||.|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 188-313 1.1e-06 22.9 In-house 59-193 (285) alignment 
Range on Protein: 188-313
Range on HMM: 59-193/285.0
NTYINASFVGCLGRT-AEYILTQHPLADTSMDFWKMMLERHVNVLVVL-----GSVEEEDEYWPDS--EPLEWYEEDITVTLTDRDEFKNIKASNLEIES
  || ||..   |.  . || || || .|  |||.|. . ..  ...|     | ||.   |.|.   | ... . .||.|    .        .| .  
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvin

DMNESHQALTMF--QISNWPsDGTTPNDHFIMVEVT
  . | . | |   |.  || |  .|.|   |.|. 
tedasseplymnhvqvpwwp.dqlapedarpmiely
ig Immunoglobulin domain 420-484 1.5e-06 19.5 Pfam-A 1-64 (64) alignment 
Range on Protein: 420-484
Range on HMM: 1-64/64.0
NNSTTITCQV-TSLTTPNITWTTTATAGITSQPVVLASSQGSDVYtsSLVLTGVTLDSIGSYTCTA
..|.|.|| | .    ....|.   .  ..||..   .  .|  .  .| .. || .  |.|||..
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqe..vLtinnvtkedsGtYtCvv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 104-143 1.8e-06 22.4 In-house 2-40 (237) alignment 
Range on Protein: 104-143
Range on HMM: 2-40/237.0
ANATKNRYINILPFDETRVILSSSKkEGSDYINANYIQGS
 |  |||| ||  .| .||.|  .   |||||||.|..| 
enkiknrygnivaydhsrvvlkgag.sgsdyinatylkgf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 105-141 1.9e-06 21.9 In-house 31-68 (297) alignment 
Range on Protein: 105-141
Range on HMM: 31-68/297.0
NA--TKNRYINILPFDETRVILSSSKkEGSDYINANYIQ
|.   |||| .|| .|.||| |  .   ..|||||.|. 
nsslrknryrdilatddtrvkllrvi.terdyinadyvv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 100-144 2e-06 22.0 In-house 28-69 (267) alignment 
Range on Protein: 100-144
Range on HMM: 28-69/267.0
AVLSANATKNRYINILPFDETRVILSSSKKEgsdYINANYIQGSQ
 . . |. .||. . ||.|.|||||. ...|   |||| |..| .
siaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyk
subfamily_PTPRN_pd Subfamily PTPRN 68-141 2.1e-06 21.7 In-house 18-93 (297) alignment 
Range on Protein: 68-141
Range on HMM: 18-93/297.0
LEYEVSRLQDEEVAKEEFVGLSDHTREFLQT-NAVLSANATKNRYINILPFDETRVILSS-SKKEGSDYINANYIQ
|.|    |....  ..|. .| ..  |   .  |    |..|||. ..||.|..|| |.. ...| ||||||  | 
lsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasail
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 99-144 2.1e-06 21.3 In-house 41-87 (440) alignment 
Range on Protein: 99-144
Range on HMM: 41-87/440.0
NAVLSANATKNRYINILPFDETRVILSSSKK-EGSDYINANYIQGSQ
 | |  |  |||| ||| .| .||.|   |    |||||| ||.| .
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
I-set Immunoglobulin I-set domain 1160-1191 3.9e-06 18.6 Pfam-A 59-90 (90) alignment 
Range on Protein: 1160-1191
Range on HMM: 59-90/90.0
SIMNVAFDDAGNYRCVLTNDYGRTESNFQLIV
 | ||  .|.|.|.|. || .|. |....| |
tIsnvevsDeGkYtckatnsagkaeakaeLkV
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 78-143 4.4e-06 20.4 In-house 19-87 (439) alignment 
Range on Protein: 78-143
Range on HMM: 19-87/439.0
EEVAKEEFVGLSDHTREF--LQTNAVLSANATKNRYINILPFDETRVIL-SSSKKEGSDYINANYIQGS
.|. ||.|  ..    ..    . |  . . ||||| .. .|| |||.|        | |||||||.| 
qeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGy
subfamily_CG42327_pd Subfamily CG42327 97-144 5.4e-06 20.3 In-house 20-68 (319) alignment 
Range on Protein: 97-144
Range on HMM: 20-68/319.0
QTNAVLSANATKNRYINILPFDETRVILSSSK-KEGSDYINANYIQGSQ
....|  .   |.|.||..|. ||||.| .   .. . |..|.|..| .
radevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyd
fn3 Fibronectin type III domain 1297-1387 6.1e-06 19.5 Pfam-A 4-75 (85) alignment 
Range on Protein: 1297-1387
Range on HMM: 4-75/85.0
TNLSSSNINNTinpSIQVKWEPLSpeDGSEFLQRYIVRVNVTDLAAsrgsrrrrqtnpvmTTLEYNVSNAESQFDFTDIKPFMSYSIGVNA
.||| |....|   |....|.| .  ||.. ...| |..  ..                  . |..|.. .... .|..|| ..|.. | |
enlsvsevtst...sltlsWsppk..dgggpitgYeveyrekggge..............ewkeftvprtttsvtltgLkpgteYefrVqa
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 204-306 8.8e-06 20.0 In-house 5-113 (198) alignment 
Range on Protein: 204-306
Range on HMM: 5-113/198.0
EYILTQHPLADTSMDFWKMMLERHVNVLVVLGSVEEEDE-----YWPDSEPLEWYEEDITV---TLTDRDEFkNIKASNLEIESDMNESHQALTMFQISN
 || ||||| .|  |||.|. |     .|..   . . |     ||| .|        ..|   |.| . ..  | |  |  ..    | . .. .|.. 
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdy.titaliltnnttappstreishyqfts

WPsDGTTPNDH
|  . ||||  
wk.ekttpnva
subfamily_CG7180_pd Subfamily CG7180 101-142 9.6e-06 19.4 In-house 38-80 (296) alignment 
Range on Protein: 101-142
Range on HMM: 38-80/296.0
VLSANATKNRYINILPFDETRVILSSSK-KEGSDYINANYIQG
. . |  |||.....|.| .||.|.. . .| |||||| |...
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvds