Gene AquePTP-sf2-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily AquePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP148_AA protein Get Run
AqueP148_AA_3-64 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 3-68 1.3e-51 166.8 In-house 4-69 (69) alignment 
Range on Protein: 3-68
Range on HMM: 4-69/69.0
LSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGKI
 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
cssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklGki
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 3-67 3.3e-50 162.3 In-house 5-69 (69) alignment 
Range on Protein: 3-67
Range on HMM: 5-69/69.0
LSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGK
 ||||||||||||||||||||||||||||||||||||||||||||||.||.||||||||||||||
cssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklGk
subfamily_PTPRD_pd Subfamily PTPRD 4-82 1.6e-24 81.5 In-house 222-300 (564) alignment 
Range on Protein: 4-82
Range on HMM: 222-300/564.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGKIEGVAFAGPQSLEET
|.| |||||||.| . . |||.||.|||.. |. .|| |..|| .|. |.|||.|..|||. |. |  . .  | |.. 
SaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 4-73 1.8e-22 74.8 In-house 221-290 (318) alignment 
Range on Protein: 4-73
Range on HMM: 221-290/318.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGKIEGVAF
|.| ||||.|||. . . ||| |.|||.|. |. .|. |..||  |. | ||.|.|.|||. |. |  | 
saGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdas
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 4-69 8.2e-22 72.7 In-house 224-289 (319) alignment 
Range on Protein: 4-69
Range on HMM: 224-289/319.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGKIE
| | |||||||.. . . |.| | ..|.|. |. .|  |..|| ... | ||..||.||.. |. |
saGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 4-66 2e-20 68.2 In-house 231-293 (298) alignment 
Range on Protein: 4-66
Range on HMM: 231-293/298.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLG
|.|.||.||||||   . |.| |. ||.|. |...|| || .|  |..|.||..|  |||. .
saGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
0050432 (Phosphotyrosine protein) phosphatases II 4-66 3.4e-18 61.5 In-house 240-302 (308) alignment 
Range on Protein: 4-66
Range on HMM: 240-302/308.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLG
| | ||||||||. . . ... |. ||.|. |...|..||.|| ... |.|...||.| ||| 
saGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 4-86 3.6e-18 60.9 In-house 232-314 (319) alignment 
Range on Protein: 4-86
Range on HMM: 232-314/319.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGKIEGVAFAGPQSLEETSSER
|.|.||||..|.. | . |.| || ||..| |. .|. |. .| .  .|.||. ||.|   .|. . .    |  ||| |.. 
saGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnks
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4-67 4.2e-18 60.5 In-house 224-287 (305) alignment 
Range on Protein: 4-67
Range on HMM: 224-287/305.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGK
| | ||||.|||. . . |.| |. ||.|. .. .|. |. || . ..|.|.|||| | .. |.
sagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 3-86 5.8e-18 60.4 In-house 195-278 (284) alignment 
Range on Protein: 3-86
Range on HMM: 195-278/284.0
LSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGKIEGVAFAGPQSLEETSSER
 |.|.||||..|.. | . |.| || ||..| |. .|. |. .| .  .|.||. ||.|   .|. . .    |  ||| |.. 
csagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnks
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 4-62 7.1e-18 59.7 In-house 220-278 (288) alignment 
Range on Protein: 4-62
Range on HMM: 220-278/288.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEA
| | ||||||||.   . ....|. .|... |. .|| |...| ... |.||...|.. 
saGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_PTPRK_pd Subfamily PTPRK 4-67 1.8e-17 58.2 In-house 218-281 (314) alignment 
Range on Protein: 4-67
Range on HMM: 218-281/314.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGK
|.|.||||||||| . .  |. |..||.|| |. .|. .. ||  |. |.||.|...||   |.
saGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcge
0051299 (Phosphotyrosine protein) phosphatases II 4-63 2e-17 59.0 In-house 227-286 (288) alignment 
Range on Protein: 4-63
Range on HMM: 227-286/288.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEAL
| | ||||||||. . . ... |. ||... |...|..||.|| ... |.|...||.|.|
saGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 4-66 2.2e-17 58.8 In-house 212-277 (284) alignment 
Range on Protein: 4-66
Range on HMM: 212-277/284.0
SSGTGRTGTFIAIMVEMARIKSEK---LVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLG
| | ||||||||... . ... |.    ||... |...|..||.|| ..  |.|...||.|.|||.
saGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_PTPRB_pd Subfamily PTPRB 4-65 2.5e-17 57.8 In-house 226-287 (293) alignment 
Range on Protein: 4-65
Range on HMM: 226-287/293.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKL
|.| ||||||||.   . .|..| .||||  |. .|. | ..| .|..|.|||..... |. 
saGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4-65 3e-17 57.4 In-house 218-279 (315) alignment 
Range on Protein: 4-65
Range on HMM: 218-279/315.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKL
|.|.|||| .|.|.  .|.|| .. ||.|| |. .|. || .|  |.|| ||.||. | |. 
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllw
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 4-64 3.6e-17 57.4 In-house 183-243 (250) alignment 
Range on Protein: 4-64
Range on HMM: 183-243/250.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALK
|.|.||.|.||||   . |.| || ||.|. .. .|| || .|  .. |.|.. .. .||.
saGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPRA_pd Subfamily PTPRA 4-69 3.9e-17 57.1 In-house 236-301 (330) alignment 
Range on Protein: 4-69
Range on HMM: 236-301/330.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGKIE
|.|.|||||||..   ..|.|.|..||.|. |. .|. || ||  .. | ||. .| |    |  |
saGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdte
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 4-64 4e-17 56.5 In-house 217-277 (515) alignment 
Range on Protein: 4-64
Range on HMM: 217-277/515.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALK
|.| |||| .|.|.  .|..|  . ||.|| |. .|. || .|  ...| ||..|. | |.
saGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 4-69 6.8e-17 56.6 In-house 229-294 (325) alignment 
Range on Protein: 4-69
Range on HMM: 229-294/325.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGKIE
|.| ||||.||..   .|..  |  ||||. |. .|| || ||   ..|..|..|||||.  |. .
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntd
0040438 (Phosphotyrosine protein) phosphatases II 4-66 9.7e-17 56.6 In-house 217-279 (317) alignment 
Range on Protein: 4-66
Range on HMM: 217-279/317.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLG
| | ||||||||. . . ... |. ||... |...|..||..| ... |.|..||| | || .
saGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0047943 (Phosphotyrosine protein) phosphatases II 4-63 1.2e-16 56.4 In-house 213-272 (273) alignment 
Range on Protein: 4-63
Range on HMM: 213-272/273.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEAL
| | ||||||||. . . ... |. ||... |...|..||.||.... |.|...||.| |
saGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 4-67 1.3e-16 55.3 In-house 207-270 (283) alignment 
Range on Protein: 4-67
Range on HMM: 207-270/283.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGK
|.| |||..|||... .  ...| .||.|. |. ||. |.|.| . . |...|.. .|    | 
stgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgd
0036941 (Phosphotyrosine protein) phosphatases II 4-66 1.3e-16 56.2 In-house 215-280 (297) alignment 
Range on Protein: 4-66
Range on HMM: 215-280/297.0
SSGTGRTGTFIAIMVEMARIK---SEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLG
| | ||.|||||. . . ...    |. |||.. |...|..||..| ... |.|...|| | || .
saGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
DSPc_SM00195 4-63 1.9e-16 55.5 In-house 203-262 (263) alignment 
Range on Protein: 4-63
Range on HMM: 203-262/263.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEAL
| | ||||||..| . . ....|| ||||. |. .|| ||.|| ....|.||..|..|..
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 4-63 1.9e-16 55.5 In-house 203-262 (263) alignment 
Range on Protein: 4-63
Range on HMM: 203-262/263.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEAL
| | ||||||..| . . ....|| ||||. |. .|| ||.|| ....|.||..|..|..
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_DSPc_SM00012 4-60 2e-16 55.4 In-house 47-104 (105) alignment 
Range on Protein: 4-60
Range on HMM: 47-104/105.0
SSGTGRTGTFIAIMVEMARIKSE-KLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALV
| | ||||||.|. . . ....| | ||||. |...|| || || .|..|.|...|| 
saGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyrall
Y_phosphatase Protein-tyrosine phosphatase 4-61 2.1e-16 55.5 Pfam-A 178-235 (235) alignment 
Range on Protein: 4-61
Range on HMM: 178-235/235.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVE
| |.||||||.|... . ....|. ||... |. .||.||.|| ....|.|...|..|
saGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 4-61 2.1e-16 55.5 In-house 178-235 (235) alignment 
Range on Protein: 4-61
Range on HMM: 178-235/235.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVE
| |.||||||.|... . ....|. ||... |. .||.||.|| ....|.|...|..|
saGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPRG_pd Subfamily PTPRG 4-66 2.5e-16 54.0 In-house 228-290 (563) alignment 
Range on Protein: 4-66
Range on HMM: 228-290/563.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLG
|.|.|||||.|..   . .|..|. |..|. .. .|  |...| .|..|.|.||||.||.. .
saGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
0039614 (Phosphotyrosine protein) phosphatases II 4-65 5e-16 54.5 In-house 230-291 (297) alignment 
Range on Protein: 4-65
Range on HMM: 230-291/297.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKL
| | ||||||||.   . ....|. ||... |...|..||..|.... |.|..|||.| || 
saGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0043336 (Phosphotyrosine protein) phosphatases II 4-62 1.2e-15 53.2 In-house 218-276 (278) alignment 
Range on Protein: 4-62
Range on HMM: 218-276/278.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEA
| | ||||||||. . . ....|. ||... |...|..||..|.... |.|...|| | 
saGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 4-67 2e-15 51.5 In-house 220-283 (315) alignment 
Range on Protein: 4-67
Range on HMM: 220-283/315.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGK
|.| |||||||..   . ... |...|..| .. .|. |  ||   ..| ||.|||.|..  | 
saGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 4-64 3.3e-15 51.0 In-house 225-285 (297) alignment 
Range on Protein: 4-64
Range on HMM: 225-285/297.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALK
..| |||| ...|   .|..| || ||||. |. .|. || .|  ...| |.. |..||| 
laGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Ptp69D_pd Subfamily Ptp69D 4-67 3.5e-15 50.9 In-house 227-290 (307) alignment 
Range on Protein: 4-67
Range on HMM: 227-290/307.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGK
| |.||.|.|.|. . . ..| |. ||||. |. .|. |...| . . |.|.. ||..  . |.
saGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd
0045450 (Phosphotyrosine protein) phosphatases II 4-62 4.5e-15 51.6 In-house 242-303 (307) alignment 
Range on Protein: 4-62
Range on HMM: 242-303/307.0
SSGTGRTGTFIAIMVEMARIKSEKL---VDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEA
| | ||||||||. . . ....|.    ||... |...|..|| .| |.. |.|...|| | 
saGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 4-63 7.9e-15 50.4 In-house 184-243 (245) alignment 
Range on Protein: 4-63
Range on HMM: 184-243/245.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEAL
| | ||||||||.   . ....|. |.... |...|..||..|.... |.|...|| | |
saGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 4-62 2.4e-14 49.0 In-house 187-245 (249) alignment 
Range on Protein: 4-62
Range on HMM: 187-245/249.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEA
| | ||||||||.   . ... |. ||... |...|..||..|.|.. |.|...|| | 
saGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0045098 (Phosphotyrosine protein) phosphatases II 4-64 4.3e-14 48.0 In-house 214-273 (278) alignment 
Range on Protein: 4-64
Range on HMM: 214-273/278.0
SSGTGRTGTFIAIMVEMARIksEKLVDIFNNVQYMRKCRPM-MVMNENEYMFIHDALVEALK
| | |||||..|..  . ..  |. ||... |...|..||. .|.|.. |.|....|.| |.
saGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 4-64 8.6e-14 46.3 In-house 209-269 (274) alignment 
Range on Protein: 4-64
Range on HMM: 209-269/274.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALK
|.| |||| |||| . . ... |. ||... |  .|  |  || ... | .|| ||.. ||
saGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3-62 1.3e-13 45.6 In-house 180-239 (239) alignment 
Range on Protein: 3-62
Range on HMM: 180-239/239.0
LSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEA
 |.| ||||.|. |   . . | .| ||||| |. .|. || ||   ..|.||| |..||
csagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 3-68 1.5e-13 45.0 In-house 219-284 (439) alignment 
Range on Protein: 3-68
Range on HMM: 219-284/439.0
LSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGKI
 |.| ||||| ||. . . ..|.|. |||   |...|| |  || .  .|.||..|..| .. |.|
csagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdi
subfamily_PTPN9_pd Subfamily PTPN9 4-62 2.8e-13 44.6 In-house 231-289 (297) alignment 
Range on Protein: 4-62
Range on HMM: 231-289/297.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEA
|.| |||||||.. . ..|....  ||... |...|. |  ..  .. |.| . |..| 
saGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_CG7180_pd Subfamily CG7180 4-62 4.5e-13 43.5 In-house 231-289 (296) alignment 
Range on Protein: 4-62
Range on HMM: 231-289/296.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEA
| |..|.| ..|| . .  .. |. ||.|. |. .|. || .| | .||..| | | ||
sdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3-61 4.6e-13 43.9 In-house 181-239 (239) alignment 
Range on Protein: 3-61
Range on HMM: 181-239/239.0
LSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVE
 |.| ||||.|. |   . . | .| ||||| |. .|. || ||   ..|.||| |..|
csagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 4-62 4.6e-13 43.8 In-house 200-258 (267) alignment 
Range on Protein: 4-62
Range on HMM: 200-258/267.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEA
| | ||.|||. |   . |.| |  .|||. .. .|. |. .|   ..|..||. |.| 
sdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 3-65 5.9e-13 43.0 In-house 176-238 (392) alignment 
Range on Protein: 3-65
Range on HMM: 176-238/392.0
LSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKL
 |.| ||||  |.|   .|. |  ..||.|| |  .|. ||.||  ...| ||. |..| |  
csagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllw
subfamily_PTPN12_pd Subfamily PTPN12 4-63 1.6e-12 41.9 In-house 215-277 (290) alignment 
Range on Protein: 4-63
Range on HMM: 215-277/290.0
SSGTGRTGTFIAIMVEMARIKSEKL---VDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEAL
|.| ||||| |||      .|.||.   .|.|. |. .|| |. .|  .. | ... |..| .
saGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 4-64 3.2e-12 40.9 In-house 224-284 (290) alignment 
Range on Protein: 4-64
Range on HMM: 224-284/290.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALK
| . ||...|.|... . . |.|  .|.|. .. .| ..| .|  ...| .|.. ....|.
SdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 4-64 3.9e-12 40.9 In-house 216-277 (281) alignment 
Range on Protein: 4-64
Range on HMM: 216-277/281.0
SSGTGRTGTFIAIMVEMARIKSE-KLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALK
|.| |||||.||.   . ....| . .|. . |. .|| | .||     | |.. |...||.
saGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN13_pd Subfamily PTPN13 4-64 4.5e-12 40.8 In-house 210-270 (273) alignment 
Range on Protein: 4-64
Range on HMM: 210-270/273.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALK
|.| ||.||.|.| | .  |. .| .|. . |. .|. |  .|  .. |.|.. |..|.||
saGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
0051429 (Phosphotyrosine protein) phosphatases II 4-63 4.7e-12 41.6 In-house 158-225 (272) alignment 
Range on Protein: 4-63
Range on HMM: 158-225/272.0
SSGTGRTGTFIAIMVEMARIKSEKLVD--------IFNNVQYMRKCRPMMVMNENEYMFIHDALVEAL
|.| .||||..|.   ....  |  ||        ... |...|..|| .| .|  |.|...||.|.|
saGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 4-61 5.7e-12 41.2 In-house 186-240 (243) alignment 
Range on Protein: 4-61
Range on HMM: 186-240/243.0
SSGTGRTGTFIAIMVEMARIkseKlVDIFNNVQYMRKCRPM-MVMNENEYMFIHDALVE
| | |||||.||. . . ..   . ||... |...|..||. .| ... |.|...|| |
saGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
0036282 (Phosphotyrosine protein) phosphatases II 5-57 8.4e-12 40.6 In-house 113-164 (174) alignment 
Range on Protein: 5-57
Range on HMM: 113-164/174.0
SGTGRTGTFIAIMVEMARIKsEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHD
 | |||||..|..  . ... |.|||... |. .|..||.|| ... |.|...
aGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0041856 (Phosphotyrosine protein) phosphatases II 5-67 3.2e-11 38.6 In-house 118-175 (182) alignment 
Range on Protein: 5-67
Range on HMM: 118-175/182.0
SGTGRTGTFIAIMvemaRIKSEKlVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGK
 | |||||..|.      .|. . |.... |...|..||.|| ..| | |...|| | |.|.|
aGvgRtgtlvaay....lmkklg.vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3-67 3.6e-11 37.0 In-house 134-198 (440) alignment 
Range on Protein: 3-67
Range on HMM: 134-198/440.0
LSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGK
 |.|.||||  ||.   .   |    .|||. .. ||. || ||   ..| |.|.|..|.|  | 
csagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegllcgd
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4-67 5.3e-11 37.0 In-house 219-282 (287) alignment 
Range on Protein: 4-67
Range on HMM: 219-282/287.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGK
| . ||...|.|. . . . | |  .|.|. .. .|  .| .|   ..|.|| |...| |. ..
sdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_CG42327_pd Subfamily CG42327 4-60 9.4e-11 35.9 In-house 255-312 (319) alignment 
Range on Protein: 4-60
Range on HMM: 255-312/319.0
SSGTGRTGTFIAIMVEMARIKSE-KLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALV
| |.||||. ||  ... ...   . ||| . |...|. |   |.. . | ||.  | 
sdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 4-61 1.2e-10 36.0 In-house 180-237 (237) alignment 
Range on Protein: 4-61
Range on HMM: 180-237/237.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVE
|.| |||| |. |   . . | .|.|||.| |. . . || ..  ...|.|||....|
sagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 4-68 2.2e-10 34.7 In-house 234-298 (301) alignment 
Range on Protein: 4-68
Range on HMM: 234-298/301.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLGKI
| . .|.|..... . .   |.|  ||.|. .. .|. .| .|   . |..|.|.. . |.| ..
SdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
0046846 (Phosphotyrosine protein) phosphatases II 5-61 2.8e-10 35.7 In-house 118-171 (176) alignment 
Range on Protein: 5-61
Range on HMM: 118-171/176.0
SGTGRTGTFIAIMvemaRIKSEKLVDIFNNVQYMRKCRP-MMVMNENEYMFIHDALVE
 | |||||..|.      ...|| ..... ....|..|| ..| ... | |..... .
aGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefell
subfamily_PTPN3_pd Subfamily PTPN3 4-63 3.1e-10 34.4 In-house 216-275 (280) alignment 
Range on Protein: 4-63
Range on HMM: 216-275/280.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEAL
|.| |||| .|.. . .| | ... | . . |. ||  | |.| ... | |. .|.... 
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 4-61 6.3e-10 33.5 In-house 205-262 (270) alignment 
Range on Protein: 4-61
Range on HMM: 205-262/270.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVE
| | |||||.||.   .  ....| ||. . .. .|| |. .|   ..| |.. |.||
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN6_pd Subfamily PTPN6 4-62 1.5e-09 32.2 In-house 235-296 (306) alignment 
Range on Protein: 4-62
Range on HMM: 235-296/306.0
SSGTGRTGTFIAIMVEMARIKSE---KLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEA
|.| ||||||| | . .  |...     .|| . |...|. |  .|  |. | |.. |. . 
saGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
0048076 (Phosphotyrosine protein) phosphatases II 5-59 1.5e-09 33.2 In-house 90-139 (145) alignment 
Range on Protein: 5-59
Range on HMM: 90-139/145.0
SGTGRTGTFIAIMvemaRIKSEKlVDIFNNVQYMRKCRPMMVMNENEYMFIHDAL
 | |||||..|..     ..... |.... ....|..||..|.|.. . |.....
aGvgRtgtlvaay....lmlllg.vsleealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 5-57 1.9e-09 32.9 In-house 92-139 (144) alignment 
Range on Protein: 5-57
Range on HMM: 92-139/144.0
SGTGRTGTFIAIMvemaRIKSEKlVDIFNNVQYMRKCRPMMVMNENEYMFIHD
 | |||||..|.     ..| .. ..... ....|..||..|.|.. ..|...
aGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
0049260 (Phosphotyrosine protein) phosphatases II 5-57 2.2e-09 32.7 In-house 98-144 (152) alignment 
Range on Protein: 5-57
Range on HMM: 98-144/152.0
SGTGRTGTFIAIMVEMarikseKLVDIFNNVQYMRKCRPMMVMNENEYMFIHD
 | |||||..|.   .      . |.... |...|..||..| |.. ..|...
aGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0043147 (Phosphotyrosine protein) phosphatases II 5-56 2.8e-09 32.4 In-house 109-154 (172) alignment 
Range on Protein: 5-56
Range on HMM: 109-154/172.0
SGTGRTGTFIAIMVEMarikseKLVDIFNNVQYMRKCRPMMVMNENEYMFIH
 | |||||..|.   .      . ..... |...|..||..| |.. |.|..
aGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly
subfamily_PTPRN_pd Subfamily PTPRN 4-62 3.2e-08 27.6 In-house 232-291 (297) alignment 
Range on Protein: 4-62
Range on HMM: 232-291/297.0
SSGTGRTGTFIAIMVEMARI-KSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEA
|.|.||||..|.| . ..|. |  | .||   ....|  || .|  .... |.  |..| 
sdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
0051082 (Phosphotyrosine protein) phosphatases II 4-59 3.9e-08 28.5 In-house 100-149 (151) alignment 
Range on Protein: 4-59
Range on HMM: 100-149/151.0
SSGTGRTGTFIAIMVEMARikseklVDIFNNVQYMRKCRPMMVMNENEYMFIHDAL
|.| |||||..|..  . .      |...  ....|..||..|  .....|.. ||
saGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 4-61 4e-08 27.2 In-house 224-281 (290) alignment 
Range on Protein: 4-61
Range on HMM: 224-281/290.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVE
|.| ||||||.|| | .  .   | .|. . |. .|..|   |  . .|. . ..|..
saGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 4-61 4.9e-08 27.3 In-house 217-275 (307) alignment 
Range on Protein: 4-61
Range on HMM: 217-275/307.0
SSGTGRTGTFIAIMVEMA-RIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVE
|.| ||.|| .|| . .   |. .   |. . |. .|. |.  . .| .|...|  |.|
saGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 5-60 6e-08 26.5 In-house 227-282 (302) alignment 
Range on Protein: 5-60
Range on HMM: 227-282/302.0
SGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALV
 |.|| |.|.. .| . .....| . | . |. .|. || .| . . |.... ||.
nGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
0049772 (Phosphotyrosine protein) phosphatases II 5-64 1e-07 27.5 In-house 221-281 (314) alignment 
Range on Protein: 5-64
Range on HMM: 221-281/314.0
SGTGRTGTFIAIMVEMARIKseklVDIFNNVQYMRKCRP-----MMVMNENEYMFIHDALVEALK
.| ||||||....  | . .    |..   ....|..||      .. . ..| ||..|| |.||
aGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk
0044763 (Phosphotyrosine protein) phosphatases II 5-62 1.5e-07 26.8 In-house 119-170 (178) alignment 
Range on Protein: 5-62
Range on HMM: 119-170/178.0
SGTGRTGTFIAIMVEMARikseKLvDIFNNVQYMRKCRPmMVMNENEYMFIHDALVEA
 | ||.||..|.   . .    .| .... ....|..|| .| |.. . ....   . 
aGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 4-63 1.6e-07 25.4 In-house 218-277 (287) alignment 
Range on Protein: 4-63
Range on HMM: 218-277/287.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEAL
. | ||.|...|..| . | ..   ||. . | ..|. |  .|     . .. .|||   
dvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_PTPN14_pd Subfamily PTPN14 4-64 1.8e-07 25.5 In-house 237-297 (300) alignment 
Range on Protein: 4-64
Range on HMM: 237-297/300.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALK
| | ||||  |   . .| .. .. .|| . .. .|. | ..| .   | |....|.. ||
saGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN23_pd Subfamily PTPN23 4-63 6.9e-07 23.4 In-house 220-280 (288) alignment 
Range on Protein: 4-63
Range on HMM: 220-280/288.0
SSGTGRTGTFIAIMVEMARIKS-EKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEAL
|.| ||||.|  ..  .. ..  . |.|| . |. .|. |  || ..... |  .| .|| 
saGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 4-60 8.6e-07 22.7 In-house 229-285 (302) alignment 
Range on Protein: 4-60
Range on HMM: 229-285/302.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALV
| | |||||..||   .   . .|  |. . |. .|.||   | .|.  ...   . 
saGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 4-66 1.5e-06 22.4 In-house 212-274 (288) alignment 
Range on Protein: 4-66
Range on HMM: 212-274/288.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEALKLG
| |.|||||.| |.. .  ....  . | . .. .|. |   .  |. |...|  . | | | 
saGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 4-63 1.6e-06 22.2 In-house 236-295 (297) alignment 
Range on Protein: 4-63
Range on HMM: 236-295/297.0
SSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNENEYMFIHDALVEAL
|.| ||.|  .  .| .|... ... |.   ....|. |...|   ... ...|| .. |
saGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 3-61 3.2e-06 21.0 In-house 228-287 (305) alignment 
Range on Protein: 3-61
Range on HMM: 228-287/305.0
LSSGTGRTGTFIAIMVEMARIKSEKLVD-IFNNVQYMRKCRPMMVMNENEYMFIHDALVE
 |.| ||||| .||   . .|  .| .  . . |. .|  | . . |. .|.|||  ...
csagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln