Gene AquePTP-sf2-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily AquePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP150_AA protein Get Run
AqueP150_AA_1-80 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 15-83 1.7e-52 169.7 In-house 1-69 (69) alignment
Range on Protein: 15-83
Range on HMM: 1-69/69.0
MVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklGk

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 16-84 5.4e-51 164.8 In-house 1-69 (69) alignment
Range on Protein: 16-84
Range on HMM: 1-69/69.0
VVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKI
|||||||||||||||||||||||||||||||||||||||||||||||||| ||.|||||||||||||||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklGki

subfamily_PTPRD_pd Subfamily PTPRD 4-96 9.3e-31 102.1 In-house 206-298 (564) alignment
Range on Protein: 4-96
Range on HMM: 206-298/564.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIEGVAFARPQSLE
|..  .|  ||.|||||.| |||||||.| . . |||.||.|||.. |. .|| |..|| .|  |||||.|..|||. |. |  . .  | |.
vralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlq

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 8-85 4.1e-27 90.1 In-house 212-289 (319) alignment
Range on Protein: 8-85
Range on HMM: 212-289/319.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIE
  . .||.||||| | |||||||.. . . |.| | ..|.|. |. .|  |..|| ..  |.||..||.||.. |. |
ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 7-89 5.7e-27 89.6 In-house 208-290 (318) alignment
Range on Protein: 7-89
Range on HMM: 208-290/318.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIEGVAF
. ..  ||.|||||.| ||||.|||. . . ||| |.|||.|. |. .|. |..||  |  |.||.|.|.|||. |. |  | 
qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdas

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 12-82 1.9e-24 81.4 In-house 223-293 (298) alignment
Range on Protein: 12-82
Range on HMM: 223-293/298.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
. |..|.||.|.||.||||||   . |.| |. ||.|. |...|| || .|  | .|.||..|  |||. .
nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf

0050432 (Phosphotyrosine protein) phosphatases II 6-82 3.7e-24 81.0 In-house 228-302 (308) alignment
Range on Protein: 6-82
Range on HMM: 228-302/308.0
QNYtpFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
. .   .||.||||| | ||||||||. . . ... |. ||.|. |...|..||.|| ..  |.|...||.| ||| 
ksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

0051299 (Phosphotyrosine protein) phosphatases II 3-79 4.2e-24 80.9 In-house 210-286 (288) alignment
Range on Protein: 3-79
Range on HMM: 210-286/288.0
IVQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
.|.. . . .||.||||| | ||||||||. . . ... |. ||... |...|..||.|| ..  |.|...||.|.|
lvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0046845 (Phosphotyrosine protein) phosphatases II 6-82 9e-24 79.8 In-house 196-277 (284) alignment
Range on Protein: 6-82
Range on HMM: 196-277/284.0
QNY--TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEK---LVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
. .  .| .||.||||| | ||||||||... . ... |.    ||... |...|..||.|| ..  |.|...||.|.|||.
ellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

0040438 (Phosphotyrosine protein) phosphatases II 2-82 5.3e-23 77.2 In-house 199-279 (317) alignment
Range on Protein: 2-82
Range on HMM: 199-279/317.0
DIVQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
..|.... . .||..|||| | ||||||||. . . ... |. ||... |...|..||..| ..  |.|..||| | || .
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

subfamily_PTPRB_pd Subfamily PTPRB 8-81 8.7e-23 75.8 In-house 214-287 (293) alignment
Range on Protein: 8-81
Range on HMM: 214-287/293.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKL
 |  ..|.|||||.| ||||||||.   . .|..| .||||  |. .|. | ..| .| .|||||..... |. 
ktaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

0047943 (Phosphotyrosine protein) phosphatases II 8-79 2e-22 75.4 In-house 201-272 (273) alignment
Range on Protein: 8-79
Range on HMM: 201-272/273.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
..| .||.||||| | ||||||||. . . ... |. ||... |...|..||.||...  |.|...||.| |
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0036941 (Phosphotyrosine protein) phosphatases II 7-82 2.2e-22 75.2 In-house 202-280 (297) alignment
Range on Protein: 7-82
Range on HMM: 202-280/297.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIK---SEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
...| .||..|||| | ||.|||||. . . ...    |. |||.. |...|..||..| ..  |.|...|| | || .
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

subfamily_PTPRK_pd Subfamily PTPRK 4-83 2.7e-22 74.0 In-house 202-281 (314) alignment
Range on Protein: 4-83
Range on HMM: 202-281/314.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
|..   . .|..|||||.|.||||||||| . .  |. |..||.|| |. .|. .. ||  |  |.||.|...||   |.
vkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcge

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4-83 3.1e-22 74.1 In-house 207-287 (305) alignment
Range on Protein: 4-83
Range on HMM: 207-287/305.0
VQQNYTPFDG-PMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
||...    | |..|||| | ||||.|||. . . |.| |. ||.|. .. .|. |. || .  .| |.|||| | .. |.
vqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd

DSPc_SM00195 6-79 4.5e-22 74.0 In-house 189-262 (263) alignment
Range on Protein: 6-79
Range on HMM: 189-262/263.0
QNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
. .   .||.||||| | ||||||..| . . ....|| ||||. |. .|| ||.|| .. .|.||..|..|..
kskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 6-79 4.5e-22 74.0 In-house 189-262 (263) alignment
Range on Protein: 6-79
Range on HMM: 189-262/263.0
QNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
. .   .||.||||| | ||||||..| . . ....|| ||||. |. .|| ||.|| .. .|.||..|..|..
kskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 4-77 5.6e-22 73.1 In-house 204-277 (288) alignment
Range on Protein: 4-77
Range on HMM: 204-277/288.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
|... .   ||..|||| | ||||||||.   . ....|. .|... |. .|| |...| ..  |.||...|..
vkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 14-101 6.4e-22 73.3 In-house 226-313 (319) alignment
Range on Protein: 14-101
Range on HMM: 226-313/319.0
PMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIEGVAFARPQSLEETSSE
..|||||.|.||||..|.. | . |.| || ||..| |. .|. |. .| . ..| ||. ||.|   .|. . .    |  ||| |..
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnk

0043336 (Phosphotyrosine protein) phosphatases II 3-78 7.1e-22 73.6 In-house 201-276 (278) alignment
Range on Protein: 3-78
Range on HMM: 201-276/278.0
IVQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
.|.. . . .||..|||| | ||||||||. . . ....|. ||... |...|..||..|...  |.|...|| | 
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

PTPc_DSPc_SM00012 7-76 7.4e-22 72.9 In-house 32-104 (105) alignment
Range on Protein: 7-76
Range on HMM: 32-104/105.0
NYTPF--DGPMVVHCSSGTGRTGTFIAIMVEMARIKSE-KLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALV
|..     .|.||||| | ||||||.|. . . ....| | ||||. |...|| || || .| .|.|...|| 
nknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyrall

0039614 (Phosphotyrosine protein) phosphatases II 8-81 7.5e-22 73.6 In-house 218-291 (297) alignment
Range on Protein: 8-81
Range on HMM: 218-291/297.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKL
..| .||..|||| | ||||||||.   . ....|. ||... |...|..||..|...  |.|..|||.| || 
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

Y_phosphatase Protein-tyrosine phosphatase 4-77 1.1e-21 72.7 Pfam-A 162-235 (235) alignment
Range on Protein: 4-77
Range on HMM: 162-235/235.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
|... .. .||.||||| |.||||||.|... . ....|. ||... |. .||.||.|| .. .|||...|..|
vekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 4-77 1.1e-21 72.7 In-house 162-235 (235) alignment
Range on Protein: 4-77
Range on HMM: 162-235/235.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
|... .. .||.||||| |.||||||.|... . ....|. ||... |. .||.||.|| .. .|||...|..|
vekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 11-80 1.2e-21 72.1 In-house 174-243 (250) alignment
Range on Protein: 11-80
Range on HMM: 174-243/250.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
 ..|..|.||.|.||.|.||||   . |.| || ||.|. .. .|| || .|  .  |.|.. .. .||.
gnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 14-102 1.4e-21 72.2 In-house 190-278 (284) alignment
Range on Protein: 14-102
Range on HMM: 190-278/284.0
PMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIEGVAFARPQSLEETSSEG
..|||||.|.||||..|.. | . |.| || ||..| |. .|. |. .| . ..| ||. ||.|   .|. . .    |  ||| |.. 
nivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnks

subfamily_PTPRA_pd Subfamily PTPRA 4-85 1.7e-21 71.5 In-house 220-301 (330) alignment
Range on Protein: 4-85
Range on HMM: 220-301/330.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIE
|..      ||.|||||.|.|||||||..   ..|.|.|..||.|. |. .|. || ||  .  | ||. .| |    |  |
vkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdte

subfamily_PTPRG_pd Subfamily PTPRG 13-82 2.4e-21 70.5 In-house 221-290 (563) alignment
Range on Protein: 13-82
Range on HMM: 221-290/563.0
GPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
||.|||||.|.|||||.|..   . .|..|. |..|. .. .|  |...| .| .|||.||||.||.. .
GPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 12-84 2.7e-21 71.0 In-house 221-293 (325) alignment
Range on Protein: 12-84
Range on HMM: 221-293/325.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKI
 .|..||||.| ||||.||..   .|..  |  ||||. |. .|| || ||    .||.|..|||||.  |. 
stpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgnt

0045450 (Phosphotyrosine protein) phosphatases II 7-78 8e-21 70.5 In-house 229-303 (307) alignment
Range on Protein: 7-78
Range on HMM: 229-303/307.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKL---VDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
. .| .||..|||| | ||||||||. . . ....|.    ||... |...|..|| .| |.  |.|...|| | 
eelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 8-106 8.8e-21 68.6 In-house 205-303 (515) alignment
Range on Protein: 8-106
Range on HMM: 205-303/515.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK--LGKIEGVAFArpQSLEETSSEGNSE
   .  |...|||.| |||| .|.|.  .|..|  . ||.|| |. .|. || .|  . .| ||..|. | |.     |  . |.  . |..  | |. .
hgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihft..dhlqdlhssgdgr

G
|
g

0042113 (Phosphotyrosine protein) phosphatases II 8-79 2e-20 68.7 In-house 171-243 (245) alignment
Range on Protein: 8-79
Range on HMM: 171-243/245.0
YT-PFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
.  . .||..|||| | ||||||||.   . ....|. |.... |...|..||..|...  |.|...|| | |
laedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 10-89 2.7e-20 67.5 In-house 208-289 (315) alignment
Range on Protein: 10-89
Range on HMM: 208-289/315.0
PFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKL--GKIEGVAF
. . ...||||.|.|||| .|.|.  .|.|| .. ||.|| |. .|. || .|  | || ||.||. | |.     |  . |
kkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihf

subfamily_Ptp69D_pd Subfamily Ptp69D 4-82 3.4e-20 67.4 In-house 211-289 (307) alignment
Range on Protein: 4-82
Range on HMM: 211-289/307.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
|.. |    .|.||||| |.||.|.|.|. . . ..| |. ||||. |. .|. |...| .   |.|.. ||..  . |
vrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg

0040439 (Phosphotyrosine protein) phosphatases II 7-78 4.7e-20 67.7 In-house 174-245 (249) alignment
Range on Protein: 7-78
Range on HMM: 174-245/249.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
...| .||..|||| | ||||||||.   . ... |. ||... |...|..||..|.|.  |.|...|| | 
eelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

0045098 (Phosphotyrosine protein) phosphatases II 8-80 5.4e-20 67.4 In-house 202-273 (278) alignment
Range on Protein: 8-80
Range on HMM: 202-273/278.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIksEKLVDIFNNVQYMRKCRPM-MVMNEIEYIFIHDALVEALK
. . .||..|||| | |||||..|..  . ..  |. ||... |...|..||. .|.|.  |.|....|.| |.
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 12-83 8.9e-20 65.7 In-house 199-270 (283) alignment
Range on Protein: 12-83
Range on HMM: 199-270/283.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
.||.|||||.| |||..|||... .  ...| .||.|. |. ||. |.|.| .   | ..|.. .|    | 
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgd

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 7-80 3.4e-19 64.1 In-house 211-285 (297) alignment
Range on Protein: 7-80
Range on HMM: 211-285/297.0
NYTPF-DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
..    .||..|||..| |||| ...|   .|..| || ||||. |. .|. || .|  . .| |.. |..||| 
dfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 5-83 5.1e-19 63.3 In-house 205-283 (315) alignment
Range on Protein: 5-83
Range on HMM: 205-283/315.0
QQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
.|  |   |..|||||.| |||||||..   . ... |...|..| .. .|. |  ||    .| ||.|||.|..  | 
kqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgd

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 12-84 1e-18 62.0 In-house 212-284 (439) alignment
Range on Protein: 12-84
Range on HMM: 212-284/439.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKI
 ||.|||||.| ||||| ||. . . ..|.|. |||   |...|| |  || .  .|.||..|..| .. |.|
ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdi

0051429 (Phosphotyrosine protein) phosphatases II 4-79 3.7e-18 61.6 In-house 147-225 (272) alignment
Range on Protein: 4-79
Range on HMM: 147-225/272.0
VQQnytpfDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVD--------IFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
...     .||..||||.| .||||..|.   ....  |  ||        ... |...|..|| .| .|  |.|...||.|.|
lld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell

subfamily_PTPN9_pd Subfamily PTPN9 8-77 1.3e-17 58.8 In-house 219-288 (297) alignment
Range on Protein: 8-77
Range on HMM: 219-288/297.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
. | . |.|||||.| |||||||.. . ..|....  ||... |...|. |  ..  .  | | . |..|
ghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

0037934 (Phosphotyrosine protein) phosphatases II 6-77 1.4e-17 59.6 In-house 167-240 (243) alignment
Range on Protein: 6-77
Range on HMM: 167-240/243.0
QN-----YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIkseKlVDIFNNVQYMRKCRPM-MVMNEIEYIFIHDALVE
..     . . .||..|||| | |||||.||. . . ..   . ||... |...|..||. .| ..  |.|...|| |
eellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 5-80 1.6e-17 58.3 In-house 209-284 (290) alignment
Range on Protein: 5-80
Range on HMM: 209-284/290.0
QQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
.... . ....||||| . ||...|.|... . . |.|  .|.|. .. .| ..| .|  . .| .|.. ....|.
ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 11-80 2.2e-17 58.0 In-house 200-269 (274) alignment
Range on Protein: 11-80
Range on HMM: 200-269/274.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
  .|.|||||.| |||| |||| . . ... |. ||... |  .|  |  || ..  | .|| ||.. ||
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 12-78 3.8e-17 57.2 In-house 192-258 (267) alignment
Range on Protein: 12-78
Range on HMM: 192-258/267.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
. |.||.|| | ||.|||. |   . |.| |  .|||. .. .|. |. .|    .||.||. |.| 
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 9-80 4.6e-17 57.0 In-house 205-277 (281) alignment
Range on Protein: 9-80
Range on HMM: 205-277/281.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSE-KLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
.  . |.|.|||.| |||||.||.   . ....| . .|. . |. .|| | .||   . | |.. |...||.
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 4-105 6.1e-17 56.1 In-house 161-264 (392) alignment
Range on Protein: 4-105
Range on HMM: 161-264/392.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKL--GKIEGVAFARPQSLEETSSE
|. ..  .  |...|||.| ||||  |.|   .|. |  ..||.|| |  .|. ||.||  . .| ||. |..| |      |  | |.   .  .|||.
vkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssd

GNSE
|.  
Gdvr

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 9-78 1e-16 55.8 In-house 170-239 (239) alignment
Range on Protein: 9-78
Range on HMM: 170-239/239.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
 |   | |.|||.| ||||.|. |   . . | .| ||||| |. .|. || ||    .|.||| |..||
lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea

0036282 (Phosphotyrosine protein) phosphatases II 10-73 1.1e-16 56.4 In-house 102-164 (174) alignment
Range on Protein: 10-73
Range on HMM: 102-164/174.0
PFDGPMVVHCSSGTGRTGTFIAIMVEMARIKsEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHD
. .||..|||| | |||||..|..  . ... |.|||... |. .|..||.|| ..  |.|...
dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy

subfamily_PTPN13_pd Subfamily PTPN13 12-80 1.4e-16 55.6 In-house 202-270 (273) alignment
Range on Protein: 12-80
Range on HMM: 202-270/273.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
 ||.|||||.| ||.||.|.| | .  |. .| .|. . |. .|. |  .|  .  |||.. |..|.||
agPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 5-83 2.3e-16 54.6 In-house 204-282 (287) alignment
Range on Protein: 5-83
Range on HMM: 204-282/287.0
QQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
.... . ....||||| . ||...|.|. . . . | |  .|.|. .. .|  .| .|    .|.|| |...| |. ..
ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe

subfamily_CG7180_pd Subfamily CG7180 9-78 2.3e-16 54.3 In-house 220-289 (296) alignment
Range on Protein: 9-78
Range on HMM: 220-289/296.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
 |  ||.||..| |..|.| ..|| . .  .. |. ||.|. |. .|. || .| |  || .| | | ||
dpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 9-77 3.4e-16 54.1 In-house 171-239 (239) alignment
Range on Protein: 9-77
Range on HMM: 171-239/239.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
 |   | |.|||.| ||||.|. |   . . | .| ||||| |. .|. || ||    .|.||| |..|
lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2-84 3.8e-16 53.7 In-house 216-298 (301) alignment
Range on Protein: 2-84
Range on HMM: 216-298/301.0
DIVQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKI
|.....  .  ||.||||| . .|.|..... . .   |.|  ||.|. .. .|. .| .|     |..|.|.. . |.| ..
dvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst

subfamily_PTPN12_pd Subfamily PTPN12 11-79 7e-16 52.9 In-house 206-277 (290) alignment
Range on Protein: 11-79
Range on HMM: 206-277/290.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKL---VDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
 | |.|||||.| ||||| |||      .|.||.   .|.|. |. .|| |. .|  .  | ... |..| .
edaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

0046846 (Phosphotyrosine protein) phosphatases II 12-77 4.3e-15 51.4 In-house 109-171 (176) alignment
Range on Protein: 12-77
Range on HMM: 109-171/176.0
DGPMVVHCSSGTGRTGTFIAIMvemaRIKSEKLVDIFNNVQYMRKCRP-MMVMNEIEYIFIHDALVE
.|| .|||| | |||||..|.      ...|| ..... ....|..|| ..| ..  | |..... .
ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefell

0041856 (Phosphotyrosine protein) phosphatases II 11-83 5.3e-15 50.9 In-house 108-175 (182) alignment
Range on Protein: 11-83
Range on HMM: 108-175/182.0
FDGPMVVHCSSGTGRTGTFIAIMvemaRIKSEKlVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
 .|| .|||| | |||||..|.      .|. . |.... |...|..||.|| ..  |.|...|| | |.|.|
eggpvlVHCsaGvgRtgtlvaay....lmkklg.vsleeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_CG42327_pd Subfamily CG42327 12-76 8.5e-15 49.2 In-house 247-312 (319) alignment
Range on Protein: 12-76
Range on HMM: 247-312/319.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSE-KLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALV
 ||.||||| |.||||. ||  ... ...   . ||| . |...|. |   |..   | ||.  | 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls

subfamily_PTPN6_pd Subfamily PTPN6 11-78 8.9e-15 49.4 In-house 226-296 (306) alignment
Range on Protein: 11-78
Range on HMM: 226-296/306.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKSE---KLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
  ||.|||||.| ||||||| | . .  |...     .|| . |...|. |  .|  |  | |.. |. . 
eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 10-84 1.5e-14 48.2 In-house 125-199 (440) alignment
Range on Protein: 10-84
Range on HMM: 125-199/440.0
PFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKI
  .||..||||.|.||||  ||.   .   |    .|||. .. ||. || ||    .| |.|.|..|.|  |  
agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegllcgdt

0048179 (Phosphotyrosine protein) phosphatases II 11-73 1.8e-14 49.1 In-house 82-139 (144) alignment
Range on Protein: 11-73
Range on HMM: 82-139/144.0
FDGPMVVHCSSGTGRTGTFIAIMvemaRIKSEKlVDIFNNVQYMRKCRPMMVMNEIEYIFIHD
 .||..|||| | |||||..|.     ..| .. ..... ....|..||..|.|.  ..|...
eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 7-77 2.2e-14 48.2 In-house 167-237 (237) alignment
Range on Protein: 7-77
Range on HMM: 167-237/237.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
.. .  || ..|||.| |||| |. |   . . | .|.|||.| |. . . || ..  . .|.|||....|
phvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

0043147 (Phosphotyrosine protein) phosphatases II 10-72 3.3e-14 48.5 In-house 98-154 (172) alignment
Range on Protein: 10-72
Range on HMM: 98-154/172.0
PFDGPMVVHCSSGTGRTGTFIAIMVEMarikseKLVDIFNNVQYMRKCRPMMVMNEIEYIFIH
  .||..|||| | |||||..|.   .      . ..... |...|..||..| |.  |.|..
spggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly

0048076 (Phosphotyrosine protein) phosphatases II 12-75 3.7e-14 48.1 In-house 81-139 (145) alignment
Range on Protein: 12-75
Range on HMM: 81-139/145.0
DGPMVVHCSSGTGRTGTFIAIMvemaRIKSEKlVDIFNNVQYMRKCRPMMVMNEIEYIFIHDAL
.||..|||| | |||||..|..     ..... |.... ....|..||..|.|.  ..|.....
ggpvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqrpgavpnpgqlrflyefe

0049260 (Phosphotyrosine protein) phosphatases II 9-73 6.2e-14 47.4 In-house 86-144 (152) alignment
Range on Protein: 9-73
Range on HMM: 86-144/152.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMarikseKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHD
   .|| .|||| | |||||..|.   .      . |.... |...|..||..| |.  ..|...
ldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_PTPN3_pd Subfamily PTPN3 11-79 6.3e-14 46.6 In-house 207-275 (280) alignment
Range on Protein: 11-79
Range on HMM: 207-275/280.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
 . |.|||||.| |||| .|.. . .| | ... | . . |. ||  | |.| ..  | |. .|.... 
keePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 12-77 6.4e-14 46.6 In-house 197-262 (270) alignment
Range on Protein: 12-77
Range on HMM: 197-262/270.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
 .|..|||| | |||||.||.   .  ....| ||. . .. .|| |. .|    .| |.. |.||
aePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

0049772 (Phosphotyrosine protein) phosphatases II 3-80 1.1e-13 47.1 In-house 205-281 (314) alignment
Range on Protein: 3-80
Range on HMM: 205-281/314.0
IVQQNytPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKseklVDIFNNVQYMRKCRP-----MMVMNEIEYIFIHDALVEALK
.....  . .|| .|||..| ||||||....  | . .    |..   ....|..||      .. . ..|.||..|| |.||
fieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk

0051082 (Phosphotyrosine protein) phosphatases II 9-75 2.5e-13 45.4 In-house 89-149 (151) alignment
Range on Protein: 9-75
Range on HMM: 89-149/151.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARikseklVDIFNNVQYMRKCRPMMVMNEIEYIFIHDAL
 . .||..||||.| |||||..|..  . .      |...  ....|..||..|  . ...|.. ||
dkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 12-77 3.4e-13 43.9 In-house 216-281 (290) alignment
Range on Protein: 12-77
Range on HMM: 216-281/290.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
 ||.|||||.| ||||||.|| | .  .   | .|. . |. .|..|   |  .|.|. . ..|..
sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 13-79 2.5e-12 41.2 In-house 211-277 (287) alignment
Range on Protein: 13-79
Range on HMM: 211-277/287.0
GPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
||.|||.. | ||.|...|..| . | ..   ||. . | ..|. |  .|   . . .. .|||   
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 13-77 8.2e-12 39.7 In-house 210-275 (307) alignment
Range on Protein: 13-77
Range on HMM: 210-275/307.0
GPMVVHCSSGTGRTGTFIAIMVEMA-RIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
 |.|||||.| ||.|| .|| . .   |. .   |. . |. .|. |.  . .|..|...|  |.|
npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

0044763 (Phosphotyrosine protein) phosphatases II 9-77 8.7e-12 40.5 In-house 107-169 (178) alignment
Range on Protein: 9-77
Range on HMM: 107-169/178.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARikseKLvDIFNNVQYMRKCRPmMVMNEIEYIFIHDALVE
 . .|| .|||| | ||.||..|.   . .    .| .... ....|..|| .| |.  . ....   .
dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr

subfamily_PTPN14_pd Subfamily PTPN14 12-80 1.3e-11 39.1 In-house 229-297 (300) alignment
Range on Protein: 12-80
Range on HMM: 229-297/300.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
. |..|||| | ||||  |   . .| .. .. .|| . .. .|. | ..| .   | |....|.. ||
kPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

Ig_3 Immunoglobulin domain 246-342 3.5e-11 35.2 Pfam-A 2-73 (75) alignment
Range on Protein: 246-342
Range on HMM: 2-73/75.0
PIFTLQPSPVSADIGDpnVTLTCNATGFP-APNITWVrlpsndlnesmildlynsdelytiDDDSMISFSTDSDTDSSSILTFDLIENDDFGYYACIA
|. ...|||.    |   |||||.|.|.| .|.|.|                         .. .... ....  .|.|.||.     .| | | |.|
Pvisvspsptvtsggn..vtLtCsaeggpppptisWy........................ietppelqgsegssssestLtissvtsedsGtYtCva

subfamily_PTPN23_pd Subfamily PTPN23 11-78 4.9e-11 37.0 In-house 211-279 (288) alignment
Range on Protein: 11-78
Range on HMM: 211-279/288.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKS-EKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
 . |.|||||.| ||||.|  ..  .. ..  . |.|| . |. .|. |  || .. .. |  .| .||
sktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_PTPRN_pd Subfamily PTPRN 6-78 6.1e-11 36.6 In-house 218-291 (297) alignment
Range on Protein: 6-78
Range on HMM: 218-291/297.0
QNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARI-KSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
. |     |.|||||.|.||||..|.| . ..|. |  | .||   ....|  || .|  . .. |.  |..| 
ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 14-77 2e-10 34.8 In-house 223-287 (305) alignment
Range on Protein: 14-77
Range on HMM: 223-287/305.0
PMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVD-IFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
|.|||||.| ||||| .||   . .|  .| .  . . |. .|  | . . |...|.|||  ...
pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

I-set Immunoglobulin I-set domain 246-345 3.2e-10 31.7 Pfam-A 1-78 (90) alignment
Range on Protein: 246-345
Range on HMM: 1-78/90.0
PIFTLQPSPVSADIGDpNVTLTCNATGFPAPNITWVRLpSNDLNEsmildlynsdelytiddDSMISFSTDSdtdSSSILTFDLIENDDFGYYACIAMQS
| || ....| . .|. .|.|.|...| | |...|..   ..|..                 .. .... ..   ... ||.. .| .| | | | |  |
pkftqklkdvevseGe.svelectveGepepsvsWakd.gselks.................sqrvkvtvee...aeytLtIsnvevsDeGkYtckatns





subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 9-79 2e-09 31.9 In-house 200-270 (285) alignment
Range on Protein: 9-79
Range on HMM: 200-270/285.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
 | . |..||||.| ||| ||. |     ||  .  ..... |. ||  |   | . ....|..  |.| .
npkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 12-81 2.1e-09 31.8 In-house 204-273 (288) alignment
Range on Protein: 12-81
Range on HMM: 204-273/288.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKL
. |.|||.| |.|||||.| |.. .  ....  . | . .. .|. |   .  |  |...|  . | | |
qkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 9-79 2.5e-09 31.4 In-house 225-295 (297) alignment
Range on Protein: 9-79
Range on HMM: 225-295/297.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
 | . ...||||.| ||.|  .  .| .|... ... |.   ....|. |...|    .. ...|| .. |
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 12-73 2.8e-09 30.9 In-house 221-282 (302) alignment
Range on Protein: 12-73
Range on HMM: 221-282/302.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHD
   ..|||| | |||||..||   .   . .|  |. . |. .|.||   | .|   |..  
kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll

subfamily_PTPN1_pd Subfamily PTPN1 12-80 1.1e-08 29.2 In-house 201-272 (290) alignment
Range on Protein: 12-80
Range on HMM: 201-272/290.0
DGPMVVHCSSGTGRTGTFIA---IMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
 || |.|||.| ||.|||.    ..|.. . .  . ||| . .  .|| |  ..       | . |..|  |
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 13-80 1.5e-08 28.8 In-house 263-345 (350) alignment
Range on Protein: 13-80
Range on HMM: 263-345/350.0
GPMVVHCSSGTGRTGTFIAIMV--------EMARIKSEK------LVD-IFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
 |..||||.| |||||....          |. . .|.|      . | |.  |. .|| |  || |   .|||..||    .
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfa

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 7-79 2e-08 28.3 In-house 214-287 (305) alignment
Range on Protein: 7-79
Range on HMM: 214-287/305.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNN-VQYMRKCRPMMVMNEIEYIFIHDALVEAL
.  |  ||.|||||.| ||||. . .   . .. . . ..  .  .| .|. |   .  . .|.|.|. ... .
karpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 10-76 3.8e-08 27.1 In-house 216-282 (302) alignment
Range on Protein: 10-76
Range on HMM: 216-282/302.0
PFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALV
. | ..|.    |.|| |.|.. .| . .....| . | . |. .|. || .| . . |.... ||.
kadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

Ig_2 Immunoglobulin domain 249-347 4e-08 25.2 Pfam-A 3-67 (80) alignment
Range on Protein: 249-347
Range on HMM: 3-67/80.0
TLQPSPVSADIGDpNVTLTCNATGFPAPNITWVRlPSNDLNESmildlynsdelytidddsmisfsT-DsdtdsssILTfDLIENDDFGYYACIAmqSND
.|...|.... |. |||||| |.|.|.|...| .  .. |..|                       .         ...  ... .| | | | |  ||.
vlsapptvvtege.nvtLtCqapgnptpkvqwyk.dgeelsqs.......................qna.......lfi.pnvsaedsGtYtCra..sns





Ig_2 Immunoglobulin domain 161-240 4.3e-08 25.1 Pfam-A 2-76 (80) alignment
Range on Protein: 161-240
Range on HMM: 2-76/80.0
PIVTPSDttQVLQFGDEIELNCSFPSA--VNYTWSVEEdpDFEETSQN--LTisyEDpSDAMDGGTYSCTATIQENrNATSEPI
|. ....  .|.  |. . |.|..|.   ....|. ..  .. ..|||  ..        | |.|||.|.|. .|   ..|...
pvlsapp..tvvtegenvtLtCqapgnptpkvqwykdg..eelsqsqnalfi...pn.vsaedsGtYtCrasnseg.skqsnsv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 13-79 6.5e-08 26.3 In-house 266-344 (349) alignment
Range on Protein: 13-79
Range on HMM: 266-344/349.0
GPMVVHCSSGTGRTGTFIAI-----MVEMARIKSEKLV-------DIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
 ...||||.| ||||... .     ..|. . .| |.         |.  |  .|| |  || |  ..|.|..||.. .
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 13-79 2.9e-07 24.9 In-house 192-257 (290) alignment
Range on Protein: 13-79
Range on HMM: 192-257/290.0
GPMVVHCSSGTGRTGTFIAIMVEMARIK-SEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVeaL
 |..|||  |  |  .. || . .  |  ... | . . ....|| | .......|. |.  ..|  |
tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv..l

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 12-75 3.8e-07 24.0 In-house 223-286 (310) alignment
Range on Protein: 12-75
Range on HMM: 223-286/310.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDAL
 || |||||.| .|... .|. ... ...  . ||. . .  ..| | . . .|..|..|.   
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 12-72 3.8e-07 24.5 In-house 134-196 (198) alignment
Range on Protein: 12-72
Range on HMM: 134-196/198.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSE--KLVDIFNNVQYMRKCRPMMVMNEIEYIFIH
| |..|||| | | || |.|. . .   .     .||.|.  . .|..|  ..     | ||.
dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 12-72 3.9e-07 24.4 In-house 135-197 (199) alignment
Range on Protein: 12-72
Range on HMM: 135-197/199.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSE--KLVDIFNNVQYMRKCRPMMVMNEIEYIFIH
| |..|||| | | || |.|. . .   .     .||.|.  . .|..|  ..     | ||.
dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

V-set Immunoglobulin V-set domain 251-352 4.4e-07 20.7 Pfam-A 7-108 (114) alignment
Range on Protein: 251-352
Range on HMM: 7-108/114.0
QPSPVSADIGDpNVTLTCNATgfP---APNITWVRLPSNDLNESMILDLYN-SDELYTIDDDSMISFSTDSDtDSSSILTFDLIENDDFGYYACIAMQSN
.|.||..  |. .|||.|  .  .     .|.|.. ...  .| .| . ..  .. ..   .   ..|.... .|.  ||.  .. .| | | | ...||
sprpvtvaeGg.svtLpCfys..ssensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngs.ksdfsLtiqnlrleDsGtYtCavsdsn

DSLMGE
   .|.
edvfga

subfamily_CDC14_pd Subfamily CDC14 12-65 5.1e-07 23.8 In-house 263-311 (328) alignment
Range on Protein: 12-65
Range on HMM: 263-311/328.0
DGPMVVHCSSGTGRTGTFIAIMVemarIKSEKLvDIFNNVQYMRKCRPMMVMNE
.| ..||| .| |||||.||  .    .|  ..    . . ..| ||| .|.  
eGaiavhCkaGLGrtGtLiacyl....mkhyrf.taaeaiawlricrPGsvigp

subfamily_egg_pd Subfamily egg 13-75 1.1e-06 22.5 In-house 202-266 (307) alignment
Range on Protein: 13-75
Range on HMM: 202-266/307.0
GPMVVHCSSGTGRTGTFIAIMVEMARIKS--EKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDAL
 |.||..  |  ...|..|| . .  .         . . |...|. |.. |   . |.|..  .
kpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlv

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 12-62 6.5e-06 20.1 In-house 214-264 (301) alignment
Range on Protein: 12-62
Range on HMM: 214-264/301.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMV
. |.|||||.| ||. .||.  .   ...... ... . .. .|. |   |
ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngv

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 13-76 8.6e-06 19.6 In-house 201-266 (281) alignment
Range on Protein: 13-76
Range on HMM: 201-266/281.0
GPMVVHCSSGTGRTGTFIAIMVEMARIKSE-KLVDIFNNVQYMRK-CRPMMVMNEIEYIFIHDALV
 | |.|||.| ||.||..|. . .  |.|   | || . | ..|   |   |    .|..|   |.
tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll