Gene AquePTP-sf2-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily AquePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP150_AA protein Get Run
AqueP150_AA_1-80 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 15-83 1.7e-52 169.7 In-house 1-69 (69) alignment 
Range on Protein: 15-83
Range on HMM: 1-69/69.0
MVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklGk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 16-84 5.4e-51 164.8 In-house 1-69 (69) alignment 
Range on Protein: 16-84
Range on HMM: 1-69/69.0
VVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKI
|||||||||||||||||||||||||||||||||||||||||||||||||| ||.|||||||||||||||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklGki
subfamily_PTPRD_pd Subfamily PTPRD 4-96 9.3e-31 102.1 In-house 206-298 (564) alignment 
Range on Protein: 4-96
Range on HMM: 206-298/564.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIEGVAFARPQSLE
|..  .|  ||.|||||.| |||||||.| . . |||.||.|||.. |. .|| |..|| .|  |||||.|..|||. |. |  . .  | |.
vralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 8-85 4.1e-27 90.1 In-house 212-289 (319) alignment 
Range on Protein: 8-85
Range on HMM: 212-289/319.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIE
  . .||.||||| | |||||||.. . . |.| | ..|.|. |. .|  |..|| ..  |.||..||.||.. |. |
ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 7-89 5.7e-27 89.6 In-house 208-290 (318) alignment 
Range on Protein: 7-89
Range on HMM: 208-290/318.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIEGVAF
. ..  ||.|||||.| ||||.|||. . . ||| |.|||.|. |. .|. |..||  |  |.||.|.|.|||. |. |  | 
qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdas
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 12-82 1.9e-24 81.4 In-house 223-293 (298) alignment 
Range on Protein: 12-82
Range on HMM: 223-293/298.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
. |..|.||.|.||.||||||   . |.| |. ||.|. |...|| || .|  | .|.||..|  |||. .
nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
0050432 (Phosphotyrosine protein) phosphatases II 6-82 3.7e-24 81.0 In-house 228-302 (308) alignment 
Range on Protein: 6-82
Range on HMM: 228-302/308.0
QNYtpFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
. .   .||.||||| | ||||||||. . . ... |. ||.|. |...|..||.|| ..  |.|...||.| ||| 
ksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0051299 (Phosphotyrosine protein) phosphatases II 3-79 4.2e-24 80.9 In-house 210-286 (288) alignment 
Range on Protein: 3-79
Range on HMM: 210-286/288.0
IVQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
.|.. . . .||.||||| | ||||||||. . . ... |. ||... |...|..||.|| ..  |.|...||.|.|
lvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 6-82 9e-24 79.8 In-house 196-277 (284) alignment 
Range on Protein: 6-82
Range on HMM: 196-277/284.0
QNY--TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEK---LVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
. .  .| .||.||||| | ||||||||... . ... |.    ||... |...|..||.|| ..  |.|...||.|.|||.
ellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0040438 (Phosphotyrosine protein) phosphatases II 2-82 5.3e-23 77.2 In-house 199-279 (317) alignment 
Range on Protein: 2-82
Range on HMM: 199-279/317.0
DIVQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
..|.... . .||..|||| | ||||||||. . . ... |. ||... |...|..||..| ..  |.|..||| | || .
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_PTPRB_pd Subfamily PTPRB 8-81 8.7e-23 75.8 In-house 214-287 (293) alignment 
Range on Protein: 8-81
Range on HMM: 214-287/293.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKL
 |  ..|.|||||.| ||||||||.   . .|..| .||||  |. .|. | ..| .| .|||||..... |. 
ktaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0047943 (Phosphotyrosine protein) phosphatases II 8-79 2e-22 75.4 In-house 201-272 (273) alignment 
Range on Protein: 8-79
Range on HMM: 201-272/273.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
..| .||.||||| | ||||||||. . . ... |. ||... |...|..||.||...  |.|...||.| |
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 7-82 2.2e-22 75.2 In-house 202-280 (297) alignment 
Range on Protein: 7-82
Range on HMM: 202-280/297.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIK---SEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
...| .||..|||| | ||.|||||. . . ...    |. |||.. |...|..||..| ..  |.|...|| | || .
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_PTPRK_pd Subfamily PTPRK 4-83 2.7e-22 74.0 In-house 202-281 (314) alignment 
Range on Protein: 4-83
Range on HMM: 202-281/314.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
|..   . .|..|||||.|.||||||||| . .  |. |..||.|| |. .|. .. ||  |  |.||.|...||   |.
vkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcge
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4-83 3.1e-22 74.1 In-house 207-287 (305) alignment 
Range on Protein: 4-83
Range on HMM: 207-287/305.0
VQQNYTPFDG-PMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
||...    | |..|||| | ||||.|||. . . |.| |. ||.|. .. .|. |. || .  .| |.|||| | .. |.
vqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
DSPc_SM00195 6-79 4.5e-22 74.0 In-house 189-262 (263) alignment 
Range on Protein: 6-79
Range on HMM: 189-262/263.0
QNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
. .   .||.||||| | ||||||..| . . ....|| ||||. |. .|| ||.|| .. .|.||..|..|..
kskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 6-79 4.5e-22 74.0 In-house 189-262 (263) alignment 
Range on Protein: 6-79
Range on HMM: 189-262/263.0
QNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
. .   .||.||||| | ||||||..| . . ....|| ||||. |. .|| ||.|| .. .|.||..|..|..
kskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 4-77 5.6e-22 73.1 In-house 204-277 (288) alignment 
Range on Protein: 4-77
Range on HMM: 204-277/288.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
|... .   ||..|||| | ||||||||.   . ....|. .|... |. .|| |...| ..  |.||...|..
vkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 14-101 6.4e-22 73.3 In-house 226-313 (319) alignment 
Range on Protein: 14-101
Range on HMM: 226-313/319.0
PMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIEGVAFARPQSLEETSSE
..|||||.|.||||..|.. | . |.| || ||..| |. .|. |. .| . ..| ||. ||.|   .|. . .    |  ||| |..
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnk
0043336 (Phosphotyrosine protein) phosphatases II 3-78 7.1e-22 73.6 In-house 201-276 (278) alignment 
Range on Protein: 3-78
Range on HMM: 201-276/278.0
IVQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
.|.. . . .||..|||| | ||||||||. . . ....|. ||... |...|..||..|...  |.|...|| | 
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
PTPc_DSPc_SM00012 7-76 7.4e-22 72.9 In-house 32-104 (105) alignment 
Range on Protein: 7-76
Range on HMM: 32-104/105.0
NYTPF--DGPMVVHCSSGTGRTGTFIAIMVEMARIKSE-KLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALV
|..     .|.||||| | ||||||.|. . . ....| | ||||. |...|| || || .| .|.|...|| 
nknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyrall
0039614 (Phosphotyrosine protein) phosphatases II 8-81 7.5e-22 73.6 In-house 218-291 (297) alignment 
Range on Protein: 8-81
Range on HMM: 218-291/297.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKL
..| .||..|||| | ||||||||.   . ....|. ||... |...|..||..|...  |.|..|||.| || 
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
Y_phosphatase Protein-tyrosine phosphatase 4-77 1.1e-21 72.7 Pfam-A 162-235 (235) alignment 
Range on Protein: 4-77
Range on HMM: 162-235/235.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
|... .. .||.||||| |.||||||.|... . ....|. ||... |. .||.||.|| .. .|||...|..|
vekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 4-77 1.1e-21 72.7 In-house 162-235 (235) alignment 
Range on Protein: 4-77
Range on HMM: 162-235/235.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
|... .. .||.||||| |.||||||.|... . ....|. ||... |. .||.||.|| .. .|||...|..|
vekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 11-80 1.2e-21 72.1 In-house 174-243 (250) alignment 
Range on Protein: 11-80
Range on HMM: 174-243/250.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
 ..|..|.||.|.||.|.||||   . |.| || ||.|. .. .|| || .|  .  |.|.. .. .||.
gnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 14-102 1.4e-21 72.2 In-house 190-278 (284) alignment 
Range on Protein: 14-102
Range on HMM: 190-278/284.0
PMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIEGVAFARPQSLEETSSEG
..|||||.|.||||..|.. | . |.| || ||..| |. .|. |. .| . ..| ||. ||.|   .|. . .    |  ||| |.. 
nivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnks
subfamily_PTPRA_pd Subfamily PTPRA 4-85 1.7e-21 71.5 In-house 220-301 (330) alignment 
Range on Protein: 4-85
Range on HMM: 220-301/330.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKIE
|..      ||.|||||.|.|||||||..   ..|.|.|..||.|. |. .|. || ||  .  | ||. .| |    |  |
vkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdte
subfamily_PTPRG_pd Subfamily PTPRG 13-82 2.4e-21 70.5 In-house 221-290 (563) alignment 
Range on Protein: 13-82
Range on HMM: 221-290/563.0
GPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
||.|||||.|.|||||.|..   . .|..|. |..|. .. .|  |...| .| .|||.||||.||.. .
GPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 12-84 2.7e-21 71.0 In-house 221-293 (325) alignment 
Range on Protein: 12-84
Range on HMM: 221-293/325.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKI
 .|..||||.| ||||.||..   .|..  |  ||||. |. .|| || ||    .||.|..|||||.  |. 
stpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgnt
0045450 (Phosphotyrosine protein) phosphatases II 7-78 8e-21 70.5 In-house 229-303 (307) alignment 
Range on Protein: 7-78
Range on HMM: 229-303/307.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKL---VDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
. .| .||..|||| | ||||||||. . . ....|.    ||... |...|..|| .| |.  |.|...|| | 
eelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 8-106 8.8e-21 68.6 In-house 205-303 (515) alignment 
Range on Protein: 8-106
Range on HMM: 205-303/515.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK--LGKIEGVAFArpQSLEETSSEGNSE
   .  |...|||.| |||| .|.|.  .|..|  . ||.|| |. .|. || .|  . .| ||..|. | |.     |  . |.  . |..  | |. .
hgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihft..dhlqdlhssgdgr

G
|
g
0042113 (Phosphotyrosine protein) phosphatases II 8-79 2e-20 68.7 In-house 171-243 (245) alignment 
Range on Protein: 8-79
Range on HMM: 171-243/245.0
YT-PFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
.  . .||..|||| | ||||||||.   . ....|. |.... |...|..||..|...  |.|...|| | |
laedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 10-89 2.7e-20 67.5 In-house 208-289 (315) alignment 
Range on Protein: 10-89
Range on HMM: 208-289/315.0
PFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKL--GKIEGVAF
. . ...||||.|.|||| .|.|.  .|.|| .. ||.|| |. .|. || .|  | || ||.||. | |.     |  . |
kkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihf
subfamily_Ptp69D_pd Subfamily Ptp69D 4-82 3.4e-20 67.4 In-house 211-289 (307) alignment 
Range on Protein: 4-82
Range on HMM: 211-289/307.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLG
|.. |    .|.||||| |.||.|.|.|. . . ..| |. ||||. |. .|. |...| .   |.|.. ||..  . |
vrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
0040439 (Phosphotyrosine protein) phosphatases II 7-78 4.7e-20 67.7 In-house 174-245 (249) alignment 
Range on Protein: 7-78
Range on HMM: 174-245/249.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
...| .||..|||| | ||||||||.   . ... |. ||... |...|..||..|.|.  |.|...|| | 
eelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0045098 (Phosphotyrosine protein) phosphatases II 8-80 5.4e-20 67.4 In-house 202-273 (278) alignment 
Range on Protein: 8-80
Range on HMM: 202-273/278.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIksEKLVDIFNNVQYMRKCRPM-MVMNEIEYIFIHDALVEALK
. . .||..|||| | |||||..|..  . ..  |. ||... |...|..||. .|.|.  |.|....|.| |.
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 12-83 8.9e-20 65.7 In-house 199-270 (283) alignment 
Range on Protein: 12-83
Range on HMM: 199-270/283.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
.||.|||||.| |||..|||... .  ...| .||.|. |. ||. |.|.| .   | ..|.. .|    | 
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 7-80 3.4e-19 64.1 In-house 211-285 (297) alignment 
Range on Protein: 7-80
Range on HMM: 211-285/297.0
NYTPF-DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
..    .||..|||..| |||| ...|   .|..| || ||||. |. .|. || .|  . .| |.. |..||| 
dfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 5-83 5.1e-19 63.3 In-house 205-283 (315) alignment 
Range on Protein: 5-83
Range on HMM: 205-283/315.0
QQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
.|  |   |..|||||.| |||||||..   . ... |...|..| .. .|. |  ||    .| ||.|||.|..  | 
kqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 12-84 1e-18 62.0 In-house 212-284 (439) alignment 
Range on Protein: 12-84
Range on HMM: 212-284/439.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKI
 ||.|||||.| ||||| ||. . . ..|.|. |||   |...|| |  || .  .|.||..|..| .. |.|
ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdi
0051429 (Phosphotyrosine protein) phosphatases II 4-79 3.7e-18 61.6 In-house 147-225 (272) alignment 
Range on Protein: 4-79
Range on HMM: 147-225/272.0
VQQnytpfDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVD--------IFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
...     .||..||||.| .||||..|.   ....  |  ||        ... |...|..|| .| .|  |.|...||.|.|
lld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell
subfamily_PTPN9_pd Subfamily PTPN9 8-77 1.3e-17 58.8 In-house 219-288 (297) alignment 
Range on Protein: 8-77
Range on HMM: 219-288/297.0
YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
. | . |.|||||.| |||||||.. . ..|....  ||... |...|. |  ..  .  | | . |..|
ghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0037934 (Phosphotyrosine protein) phosphatases II 6-77 1.4e-17 59.6 In-house 167-240 (243) alignment 
Range on Protein: 6-77
Range on HMM: 167-240/243.0
QN-----YTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIkseKlVDIFNNVQYMRKCRPM-MVMNEIEYIFIHDALVE
..     . . .||..|||| | |||||.||. . . ..   . ||... |...|..||. .| ..  |.|...|| |
eellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 5-80 1.6e-17 58.3 In-house 209-284 (290) alignment 
Range on Protein: 5-80
Range on HMM: 209-284/290.0
QQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
.... . ....||||| . ||...|.|... . . |.|  .|.|. .. .| ..| .|  . .| .|.. ....|.
ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 11-80 2.2e-17 58.0 In-house 200-269 (274) alignment 
Range on Protein: 11-80
Range on HMM: 200-269/274.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
  .|.|||||.| |||| |||| . . ... |. ||... |  .|  |  || ..  | .|| ||.. ||
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 12-78 3.8e-17 57.2 In-house 192-258 (267) alignment 
Range on Protein: 12-78
Range on HMM: 192-258/267.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
. |.||.|| | ||.|||. |   . |.| |  .|||. .. .|. |. .|    .||.||. |.| 
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 9-80 4.6e-17 57.0 In-house 205-277 (281) alignment 
Range on Protein: 9-80
Range on HMM: 205-277/281.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSE-KLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
.  . |.|.|||.| |||||.||.   . ....| . .|. . |. .|| | .||   . | |.. |...||.
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 4-105 6.1e-17 56.1 In-house 161-264 (392) alignment 
Range on Protein: 4-105
Range on HMM: 161-264/392.0
VQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKL--GKIEGVAFARPQSLEETSSE
|. ..  .  |...|||.| ||||  |.|   .|. |  ..||.|| |  .|. ||.||  . .| ||. |..| |      |  | |.   .  .|||.
vkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssd

GNSE
|.  
Gdvr
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 9-78 1e-16 55.8 In-house 170-239 (239) alignment 
Range on Protein: 9-78
Range on HMM: 170-239/239.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
 |   | |.|||.| ||||.|. |   . . | .| ||||| |. .|. || ||    .|.||| |..||
lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
0036282 (Phosphotyrosine protein) phosphatases II 10-73 1.1e-16 56.4 In-house 102-164 (174) alignment 
Range on Protein: 10-73
Range on HMM: 102-164/174.0
PFDGPMVVHCSSGTGRTGTFIAIMVEMARIKsEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHD
. .||..|||| | |||||..|..  . ... |.|||... |. .|..||.|| ..  |.|...
dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_PTPN13_pd Subfamily PTPN13 12-80 1.4e-16 55.6 In-house 202-270 (273) alignment 
Range on Protein: 12-80
Range on HMM: 202-270/273.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
 ||.|||||.| ||.||.|.| | .  |. .| .|. . |. .|. |  .|  .  |||.. |..|.||
agPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 5-83 2.3e-16 54.6 In-house 204-282 (287) alignment 
Range on Protein: 5-83
Range on HMM: 204-282/287.0
QQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
.... . ....||||| . ||...|.|. . . . | |  .|.|. .. .|  .| .|    .|.|| |...| |. ..
ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_CG7180_pd Subfamily CG7180 9-78 2.3e-16 54.3 In-house 220-289 (296) alignment 
Range on Protein: 9-78
Range on HMM: 220-289/296.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
 |  ||.||..| |..|.| ..|| . .  .. |. ||.|. |. .|. || .| |  || .| | | ||
dpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 9-77 3.4e-16 54.1 In-house 171-239 (239) alignment 
Range on Protein: 9-77
Range on HMM: 171-239/239.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
 |   | |.|||.| ||||.|. |   . . | .| ||||| |. .|. || ||    .|.||| |..|
lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2-84 3.8e-16 53.7 In-house 216-298 (301) alignment 
Range on Protein: 2-84
Range on HMM: 216-298/301.0
DIVQQNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKI
|.....  .  ||.||||| . .|.|..... . .   |.|  ||.|. .. .|. .| .|     |..|.|.. . |.| ..
dvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_PTPN12_pd Subfamily PTPN12 11-79 7e-16 52.9 In-house 206-277 (290) alignment 
Range on Protein: 11-79
Range on HMM: 206-277/290.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKL---VDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
 | |.|||||.| ||||| |||      .|.||.   .|.|. |. .|| |. .|  .  | ... |..| .
edaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0046846 (Phosphotyrosine protein) phosphatases II 12-77 4.3e-15 51.4 In-house 109-171 (176) alignment 
Range on Protein: 12-77
Range on HMM: 109-171/176.0
DGPMVVHCSSGTGRTGTFIAIMvemaRIKSEKLVDIFNNVQYMRKCRP-MMVMNEIEYIFIHDALVE
.|| .|||| | |||||..|.      ...|| ..... ....|..|| ..| ..  | |..... .
ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefell
0041856 (Phosphotyrosine protein) phosphatases II 11-83 5.3e-15 50.9 In-house 108-175 (182) alignment 
Range on Protein: 11-83
Range on HMM: 108-175/182.0
FDGPMVVHCSSGTGRTGTFIAIMvemaRIKSEKlVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGK
 .|| .|||| | |||||..|.      .|. . |.... |...|..||.|| ..  |.|...|| | |.|.|
eggpvlVHCsaGvgRtgtlvaay....lmkklg.vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_CG42327_pd Subfamily CG42327 12-76 8.5e-15 49.2 In-house 247-312 (319) alignment 
Range on Protein: 12-76
Range on HMM: 247-312/319.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSE-KLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALV
 ||.||||| |.||||. ||  ... ...   . ||| . |...|. |   |..   | ||.  | 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_PTPN6_pd Subfamily PTPN6 11-78 8.9e-15 49.4 In-house 226-296 (306) alignment 
Range on Protein: 11-78
Range on HMM: 226-296/306.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKSE---KLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
  ||.|||||.| ||||||| | . .  |...     .|| . |...|. |  .|  |  | |.. |. . 
eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 10-84 1.5e-14 48.2 In-house 125-199 (440) alignment 
Range on Protein: 10-84
Range on HMM: 125-199/440.0
PFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKLGKI
  .||..||||.|.||||  ||.   .   |    .|||. .. ||. || ||    .| |.|.|..|.|  |  
agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegllcgdt
0048179 (Phosphotyrosine protein) phosphatases II 11-73 1.8e-14 49.1 In-house 82-139 (144) alignment 
Range on Protein: 11-73
Range on HMM: 82-139/144.0
FDGPMVVHCSSGTGRTGTFIAIMvemaRIKSEKlVDIFNNVQYMRKCRPMMVMNEIEYIFIHD
 .||..|||| | |||||..|.     ..| .. ..... ....|..||..|.|.  ..|...
eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 7-77 2.2e-14 48.2 In-house 167-237 (237) alignment 
Range on Protein: 7-77
Range on HMM: 167-237/237.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
.. .  || ..|||.| |||| |. |   . . | .|.|||.| |. . . || ..  . .|.|||....|
phvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0043147 (Phosphotyrosine protein) phosphatases II 10-72 3.3e-14 48.5 In-house 98-154 (172) alignment 
Range on Protein: 10-72
Range on HMM: 98-154/172.0
PFDGPMVVHCSSGTGRTGTFIAIMVEMarikseKLVDIFNNVQYMRKCRPMMVMNEIEYIFIH
  .||..|||| | |||||..|.   .      . ..... |...|..||..| |.  |.|..
spggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly
0048076 (Phosphotyrosine protein) phosphatases II 12-75 3.7e-14 48.1 In-house 81-139 (145) alignment 
Range on Protein: 12-75
Range on HMM: 81-139/145.0
DGPMVVHCSSGTGRTGTFIAIMvemaRIKSEKlVDIFNNVQYMRKCRPMMVMNEIEYIFIHDAL
.||..|||| | |||||..|..     ..... |.... ....|..||..|.|.  ..|.....
ggpvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqrpgavpnpgqlrflyefe
0049260 (Phosphotyrosine protein) phosphatases II 9-73 6.2e-14 47.4 In-house 86-144 (152) alignment 
Range on Protein: 9-73
Range on HMM: 86-144/152.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMarikseKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHD
   .|| .|||| | |||||..|.   .      . |.... |...|..||..| |.  ..|...
ldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPN3_pd Subfamily PTPN3 11-79 6.3e-14 46.6 In-house 207-275 (280) alignment 
Range on Protein: 11-79
Range on HMM: 207-275/280.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
 . |.|||||.| |||| .|.. . .| | ... | . . |. ||  | |.| ..  | |. .|.... 
keePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 12-77 6.4e-14 46.6 In-house 197-262 (270) alignment 
Range on Protein: 12-77
Range on HMM: 197-262/270.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
 .|..|||| | |||||.||.   .  ....| ||. . .. .|| |. .|    .| |.. |.||
aePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
0049772 (Phosphotyrosine protein) phosphatases II 3-80 1.1e-13 47.1 In-house 205-281 (314) alignment 
Range on Protein: 3-80
Range on HMM: 205-281/314.0
IVQQNytPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKseklVDIFNNVQYMRKCRP-----MMVMNEIEYIFIHDALVEALK
.....  . .|| .|||..| ||||||....  | . .    |..   ....|..||      .. . ..|.||..|| |.||
fieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk
0051082 (Phosphotyrosine protein) phosphatases II 9-75 2.5e-13 45.4 In-house 89-149 (151) alignment 
Range on Protein: 9-75
Range on HMM: 89-149/151.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARikseklVDIFNNVQYMRKCRPMMVMNEIEYIFIHDAL
 . .||..||||.| |||||..|..  . .      |...  ....|..||..|  . ...|.. ||
dkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 12-77 3.4e-13 43.9 In-house 216-281 (290) alignment 
Range on Protein: 12-77
Range on HMM: 216-281/290.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
 ||.|||||.| ||||||.|| | .  .   | .|. . |. .|..|   |  .|.|. . ..|..
sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 13-79 2.5e-12 41.2 In-house 211-277 (287) alignment 
Range on Protein: 13-79
Range on HMM: 211-277/287.0
GPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
||.|||.. | ||.|...|..| . | ..   ||. . | ..|. |  .|   . . .. .|||   
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 13-77 8.2e-12 39.7 In-house 210-275 (307) alignment 
Range on Protein: 13-77
Range on HMM: 210-275/307.0
GPMVVHCSSGTGRTGTFIAIMVEMA-RIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
 |.|||||.| ||.|| .|| . .   |. .   |. . |. .|. |.  . .|..|...|  |.|
npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
0044763 (Phosphotyrosine protein) phosphatases II 9-77 8.7e-12 40.5 In-house 107-169 (178) alignment 
Range on Protein: 9-77
Range on HMM: 107-169/178.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARikseKLvDIFNNVQYMRKCRPmMVMNEIEYIFIHDALVE
 . .|| .|||| | ||.||..|.   . .    .| .... ....|..|| .| |.  . ....   .
dekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_PTPN14_pd Subfamily PTPN14 12-80 1.3e-11 39.1 In-house 229-297 (300) alignment 
Range on Protein: 12-80
Range on HMM: 229-297/300.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
. |..|||| | ||||  |   . .| .. .. .|| . .. .|. | ..| .   | |....|.. ||
kPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
Ig_3 Immunoglobulin domain 246-342 3.5e-11 35.2 Pfam-A 2-73 (75) alignment 
Range on Protein: 246-342
Range on HMM: 2-73/75.0
PIFTLQPSPVSADIGDpnVTLTCNATGFP-APNITWVrlpsndlnesmildlynsdelytiDDDSMISFSTDSDTDSSSILTFDLIENDDFGYYACIA
|. ...|||.    |   |||||.|.|.| .|.|.|                         .. .... ....  .|.|.||.     .| | | |.|
Pvisvspsptvtsggn..vtLtCsaeggpppptisWy........................ietppelqgsegssssestLtissvtsedsGtYtCva
subfamily_PTPN23_pd Subfamily PTPN23 11-78 4.9e-11 37.0 In-house 211-279 (288) alignment 
Range on Protein: 11-78
Range on HMM: 211-279/288.0
FDGPMVVHCSSGTGRTGTFIAIMVEMARIKS-EKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
 . |.|||||.| ||||.|  ..  .. ..  . |.|| . |. .|. |  || .. .. |  .| .||
sktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPRN_pd Subfamily PTPRN 6-78 6.1e-11 36.6 In-house 218-291 (297) alignment 
Range on Protein: 6-78
Range on HMM: 218-291/297.0
QNYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARI-KSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEA
. |     |.|||||.|.||||..|.| . ..|. |  | .||   ....|  || .|  . .. |.  |..| 
ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 14-77 2e-10 34.8 In-house 223-287 (305) alignment 
Range on Protein: 14-77
Range on HMM: 223-287/305.0
PMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVD-IFNNVQYMRKCRPMMVMNEIEYIFIHDALVE
|.|||||.| ||||| .||   . .|  .| .  . . |. .|  | . . |...|.|||  ...
pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
I-set Immunoglobulin I-set domain 246-345 3.2e-10 31.7 Pfam-A 1-78 (90) alignment 
Range on Protein: 246-345
Range on HMM: 1-78/90.0
PIFTLQPSPVSADIGDpNVTLTCNATGFPAPNITWVRLpSNDLNEsmildlynsdelytiddDSMISFSTDSdtdSSSILTFDLIENDDFGYYACIAMQS
| || ....| . .|. .|.|.|...| | |...|..   ..|..                 .. .... ..   ... ||.. .| .| | | | |  |
pkftqklkdvevseGe.svelectveGepepsvsWakd.gselks.................sqrvkvtvee...aeytLtIsnvevsDeGkYtckatns
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 9-79 2e-09 31.9 In-house 200-270 (285) alignment 
Range on Protein: 9-79
Range on HMM: 200-270/285.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
 | . |..||||.| ||| ||. |     ||  .  ..... |. ||  |   | . ....|..  |.| .
npkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 12-81 2.1e-09 31.8 In-house 204-273 (288) alignment 
Range on Protein: 12-81
Range on HMM: 204-273/288.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALKL
. |.|||.| |.|||||.| |.. .  ....  . | . .. .|. |   .  |  |...|  . | | |
qkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 9-79 2.5e-09 31.4 In-house 225-295 (297) alignment 
Range on Protein: 9-79
Range on HMM: 225-295/297.0
TPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
 | . ...||||.| ||.|  .  .| .|... ... |.   ....|. |...|    .. ...|| .. |
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 12-73 2.8e-09 30.9 In-house 221-282 (302) alignment 
Range on Protein: 12-73
Range on HMM: 221-282/302.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHD
   ..|||| | |||||..||   .   . .|  |. . |. .|.||   | .|   |..  
kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll
subfamily_PTPN1_pd Subfamily PTPN1 12-80 1.1e-08 29.2 In-house 201-272 (290) alignment 
Range on Protein: 12-80
Range on HMM: 201-272/290.0
DGPMVVHCSSGTGRTGTFIA---IMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
 || |.|||.| ||.|||.    ..|.. . .  . ||| . .  .|| |  ..       | . |..|  |
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 13-80 1.5e-08 28.8 In-house 263-345 (350) alignment 
Range on Protein: 13-80
Range on HMM: 263-345/350.0
GPMVVHCSSGTGRTGTFIAIMV--------EMARIKSEK------LVD-IFNNVQYMRKCRPMMVMNEIEYIFIHDALVEALK
 |..||||.| |||||....          |. . .|.|      . | |.  |. .|| |  || |   .|||..||    .
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfa
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 7-79 2e-08 28.3 In-house 214-287 (305) alignment 
Range on Protein: 7-79
Range on HMM: 214-287/305.0
NYTPFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNN-VQYMRKCRPMMVMNEIEYIFIHDALVEAL
.  |  ||.|||||.| ||||. . .   . .. . . ..  .  .| .|. |   .  . .|.|.|. ... .
karpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 10-76 3.8e-08 27.1 In-house 216-282 (302) alignment 
Range on Protein: 10-76
Range on HMM: 216-282/302.0
PFDGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALV
. | ..|.    |.|| |.|.. .| . .....| . | . |. .|. || .| . . |.... ||.
kadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
Ig_2 Immunoglobulin domain 249-347 4e-08 25.2 Pfam-A 3-67 (80) alignment 
Range on Protein: 249-347
Range on HMM: 3-67/80.0
TLQPSPVSADIGDpNVTLTCNATGFPAPNITWVRlPSNDLNESmildlynsdelytidddsmisfsT-DsdtdsssILTfDLIENDDFGYYACIAmqSND
.|...|.... |. |||||| |.|.|.|...| .  .. |..|                       .         ...  ... .| | | | |  ||.
vlsapptvvtege.nvtLtCqapgnptpkvqwyk.dgeelsqs.......................qna.......lfi.pnvsaedsGtYtCra..sns
Ig_2 Immunoglobulin domain 161-240 4.3e-08 25.1 Pfam-A 2-76 (80) alignment 
Range on Protein: 161-240
Range on HMM: 2-76/80.0
PIVTPSDttQVLQFGDEIELNCSFPSA--VNYTWSVEEdpDFEETSQN--LTisyEDpSDAMDGGTYSCTATIQENrNATSEPI
|. ....  .|.  |. . |.|..|.   ....|. ..  .. ..|||  ..        | |.|||.|.|. .|   ..|...
pvlsapp..tvvtegenvtLtCqapgnptpkvqwykdg..eelsqsqnalfi...pn.vsaedsGtYtCrasnseg.skqsnsv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 13-79 6.5e-08 26.3 In-house 266-344 (349) alignment 
Range on Protein: 13-79
Range on HMM: 266-344/349.0
GPMVVHCSSGTGRTGTFIAI-----MVEMARIKSEKLV-------DIFNNVQYMRKCRPMMVMNEIEYIFIHDALVEAL
 ...||||.| ||||... .     ..|. . .| |.         |.  |  .|| |  || |  ..|.|..||.. .
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 13-79 2.9e-07 24.9 In-house 192-257 (290) alignment 
Range on Protein: 13-79
Range on HMM: 192-257/290.0
GPMVVHCSSGTGRTGTFIAIMVEMARIK-SEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDALVeaL
 |..|||  |  |  .. || . .  |  ... | . . ....|| | .......|. |.  ..|  |
tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv..l
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 12-75 3.8e-07 24.0 In-house 223-286 (310) alignment 
Range on Protein: 12-75
Range on HMM: 223-286/310.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDAL
 || |||||.| .|... .|. ... ...  . ||. . .  ..| | . . .|..|..|.   
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 12-72 3.8e-07 24.5 In-house 134-196 (198) alignment 
Range on Protein: 12-72
Range on HMM: 134-196/198.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSE--KLVDIFNNVQYMRKCRPMMVMNEIEYIFIH
| |..|||| | | || |.|. . .   .     .||.|.  . .|..|  ..     | ||.
dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 12-72 3.9e-07 24.4 In-house 135-197 (199) alignment 
Range on Protein: 12-72
Range on HMM: 135-197/199.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSE--KLVDIFNNVQYMRKCRPMMVMNEIEYIFIH
| |..|||| | | || |.|. . .   .     .||.|.  . .|..|  ..     | ||.
dapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
V-set Immunoglobulin V-set domain 251-352 4.4e-07 20.7 Pfam-A 7-108 (114) alignment 
Range on Protein: 251-352
Range on HMM: 7-108/114.0
QPSPVSADIGDpNVTLTCNATgfP---APNITWVRLPSNDLNESMILDLYN-SDELYTIDDDSMISFSTDSDtDSSSILTFDLIENDDFGYYACIAMQSN
.|.||..  |. .|||.|  .  .     .|.|.. ...  .| .| . ..  .. ..   .   ..|.... .|.  ||.  .. .| | | | ...||
sprpvtvaeGg.svtLpCfys..ssensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngs.ksdfsLtiqnlrleDsGtYtCavsdsn

DSLMGE
   .|.
edvfga
subfamily_CDC14_pd Subfamily CDC14 12-65 5.1e-07 23.8 In-house 263-311 (328) alignment 
Range on Protein: 12-65
Range on HMM: 263-311/328.0
DGPMVVHCSSGTGRTGTFIAIMVemarIKSEKLvDIFNNVQYMRKCRPMMVMNE
.| ..||| .| |||||.||  .    .|  ..    . . ..| ||| .|.  
eGaiavhCkaGLGrtGtLiacyl....mkhyrf.taaeaiawlricrPGsvigp
subfamily_egg_pd Subfamily egg 13-75 1.1e-06 22.5 In-house 202-266 (307) alignment 
Range on Protein: 13-75
Range on HMM: 202-266/307.0
GPMVVHCSSGTGRTGTFIAIMVEMARIKS--EKLVDIFNNVQYMRKCRPMMVMNEIEYIFIHDAL
 |.||..  |  ...|..|| . .  .         . . |...|. |.. |   . |.|..  .
kpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 12-62 6.5e-06 20.1 In-house 214-264 (301) alignment 
Range on Protein: 12-62
Range on HMM: 214-264/301.0
DGPMVVHCSSGTGRTGTFIAIMVEMARIKSEKLVDIFNNVQYMRKCRPMMV
. |.|||||.| ||. .||.  .   ...... ... . .. .|. |   |
ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 13-76 8.6e-06 19.6 In-house 201-266 (281) alignment 
Range on Protein: 13-76
Range on HMM: 201-266/281.0
GPMVVHCSSGTGRTGTFIAIMVEMARIKSE-KLVDIFNNVQYMRK-CRPMMVMNEIEYIFIHDALV
 | |.|||.| ||.||..|. . .  |.|   | || . | ..|   |   |    .|..|   |.
tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll