Gene INPP5 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily INPP5F
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP152_AA protein Get Run
AqueP152_AA_388-700 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_INPP5F_pd Subfamily INPP5F 390-723 1.6e-132 434.6 In-house 196-526 (951) alignment 
Range on Protein: 390-723
Range on HMM: 196-526/951.0
QAFVMVPNISSDVPTVTMALISRRSRHRAGTRYLRRGVDNEGHVANFVETEMLLLAATHLLSFIVVRGSVPVYWTQPGNRYRPLPIIEQTDEETAVAFER
| || . .||    .|...|||||||.|||||. |||.|..|.||||||||..| .... |||. .||||||.|.|.|..|.| . |....|||  ||..
qGfvetkeisieklkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqsgkkykpkikitrseeetqpaFde

HFESQMNLYREQVIVNLINQSGRERIVSTAFEKQLLTLDCPSLTYVAFDFHHHCKVNQWHNINLLLSNIEQYITRQKYFWIDNDEgssgQPLCYQNGVFR
||..|.. |...|||||..|...|...|.|...|||.|........ ||||.... ....|.. |...|.. |.. .||. |..|    . .. |.||||
hfkeqlkkygkvvivnllsqkssekklskaykeqllkleskdvflikfdfheetsgekfenvsklielikneikevgyfsydvke....kviseqkgvfR

VNCMDCLDRTNVVQSVICKEFIQTALQKLGLIDPFTSLT-GQFLRHYQELWANNGDTISRQYTGTDAMKGDLTRYGQRRLYGVMKDGYNSAHRYLQSLFR
.||.||||||||||. |.|......|.||||..| .|..  ..|.....|||.|||.|||||.||.|.|||||| |.|.|.||.||||.|..|| .. |.
tnclDcldrtNvvqqaiskavlelqleklglfepessiddeellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfk

DAYRQVVIDLQQGAPVQDALTTLSQSQKGISEDEQ
|.||| |||| .|   ..  ..| . .|.  |.|.
dkyrqkvidlllGklpkqevvelidpkkeekeeel
Sac_COG5329 398-699 1.5e-110 361.9 In-house 218-515 (1070) alignment 
Range on Protein: 398-699
Range on HMM: 218-515/1070.0
ISSDVPTVTMALISRRSRHRAGTRYLRRGVDNEGHVANFVETEMLLLAATHLLSFIVVRGSVPVYWTQ-PGNRYRPLPIIEQTDEETAVAFERHFESQMN
|..   |....|||||| .|||||.|.||||..|.||||||||. . .. .  ||. ||||.|..|.|  .. . |   | . .|.|  ||..||.....
ikvkkktiaLtlISRrSskragtRflarGvDddGnvanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfe

LYREQVIVNLINQSGRERIVSTAFEKQLLTLDCPSLTYVAFDFHHHCKVNQWHNINLLLSNIEQYITRQKYFWIDNDEgssGQPLCYQNGVFRVNCMDCL
 |  ..||||......|. .| ..||.|  .. | .... ||||.... ........||  ||| .. ..||  |. |   |. .  |.||||.||.|||
kYGdvhivNLlktKssEieLseryekhlklsekpkihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvke...gkliseQdGVfRtNClDCL

DRTNVVQSVICKEFIQTALQKLGLIDPFTSLtgQFLRHYQELWANNGDTISRQYTGTDAMKGDLTRYGQRRLYGVMKDGYNSAHRYLQSLFRDAYRQVVI
|||||.|..|.|. ..  ..... |.  ..   .||  ..||||.|||.||..||||.|.|...|| |.| . | ..|  .|. |. .  | |. .|  |
DRTNviQqliskrvlleqfrsikvisaidde..dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdai

DLQ
|| 
dll
subfamily_SAC1_pd Subfamily SAC1 392-701 5.9e-109 355.7 In-house 144-451 (458) alignment 
Range on Protein: 392-701
Range on HMM: 144-451/458.0
FVMVPNISSDVPTVTMALISRRSRHRAGTRYLRRGVDNEGHVANFVETEMLLLAATHLLSFIVVRGSVPVYWTQPGN-RYRPLPIIEQTdEETAVAFERH
|. . ..| .  .....|||||| .|||||| .||||.||.|||||||| ...| ..| ||. ||||.|..|.| .| .|.| . .... |..  ||..|
fikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveaekaltsFvqvRGsiPllWsqkpnLkykPkvklses.edsldafkkh

FESQMNLYREQVIVNLINQSGRERIVSTAFEKQLLTLDCPSLTYVAFDFHHHCKVNQWHNINLLLSNIEQYITRQKYFWIDNDEGssgqPLCYQNGVFRV
...|..|| |.|.|||..| |.|  .  |.|. . .|. ... |||||||..|. ..|. ..||. ..|.   .. ||. ....         |.||.| 
ldeqielygenvlvnLvdqkGsEkklgeayesvvralnkkkikyvafDFHkeCrkmrwdrlklLidqlekelsqegyflkseekk....ivkeqkgvvRt

NCMDCLDRTNVVQSVICKEFIQTALQKLGLIDPFTSLT--GQFLRHYQELWANNGDTISRQYTGTDAMKGDLTRYGQRRLYGVMKDGYNSAHRYLQSLFR
||.|||||||||||.. .| .|. |..||..   ..|.   ........|||.|.|..| ||.|| |.| | || |.| | |...||.||. ||..  | 
nCiDcLDRtnvvqsllarevLqkqleslgvlateskledsaeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfl

DAYRQVVIDLQQG
| .||  |||  |
dgerqdsidLflg
Syja_N SacI homology domain 102-550 8.9e-86 278.9 Pfam-A 2-319 (319) alignment 
Range on Protein: 102-550
Range on HMM: 2-319/319.0
FGLIGKLQLLSntGWYLLIITEAKSIGRLPNtDSDVFCIERVALISLSAEKSIDEIKMEtyaqdrrekdVKDIGKLEKKLKEALLQMFNGSRSFYFSYET
.|..| ..|||  . |||.||........ . . ... |..|..|.|. |.. .....|           |.  . |..   .||. .  |.||||||..
ygilGlirlls..esyllvitkrekvakirg.ehpiykiksvefiplnseeeessaiee..........ekeeeekeeekllkllkkllssgsfYfSydy

DLTQSVQRKHDCGDANK------LRKWERVDERFFWNKNMLQDLLDNDKTIDKWVLPVVQGYIEIKTIPIPspdqlgiflkkqqshdthvttfllgtppk
|||.|.|||.    ..|      |  ...|||||.||.|.|..|.. ..  ..|.||..||..|...| .                              
DltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievk.............................

egmatasvdveerggeeikrndrkdehdiysstplaaslpnelndtltqsnqhqldqsitdtqsdlisfhtdskssqsdlkssqidpksdsessqafvmv
                                                                                                    
....................................................................................................

pnissDVPTVTMALISRRSRHRAGTRYLRRGVDNEGHVANFVETEMLLL-A---ATHLLSFIVVRGSVPVYWTQ-PGNRYRPLPIIEQTDEETAVAFERH
     .  .|...||||||..||||||||||.|..|.||||||||...      . ...||. .|||||..|.| ..  ..| . |..  |..  ||..|
.....skkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkH

FESQMNLYREQVIVNLINQSGRERIVSTAFEKQLLTL-----DCPSLTYVAFDFHHHCKVNQWHN
|..... |...|.|||....|||. .| |.|... .|     .   | |..||||..|| ....|
fkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfen
Syja_N SacI homology domain 102-550 8.9e-86 278.9 In-house 2-319 (319) alignment 
Range on Protein: 102-550
Range on HMM: 2-319/319.0
FGLIGKLQLLSntGWYLLIITEAKSIGRLPNtDSDVFCIERVALISLSAEKSIDEIKMEtyaqdrrekdVKDIGKLEKKLKEALLQMFNGSRSFYFSYET
.|..| ..|||  . |||.||........ . . ... |..|..|.|. |.. .....|           |.  . |..   .||. .  |.||||||..
ygilGlirlls..esyllvitkrekvakirg.ehpiykiksvefiplnseeeessaiee..........ekeeeekeeekllkllkkllssgsfYfSydy

DLTQSVQRKHDCGDANK------LRKWERVDERFFWNKNMLQDLLDNDKTIDKWVLPVVQGYIEIKTIPIPspdqlgiflkkqqshdthvttfllgtppk
|||.|.|||.    ..|      |  ...|||||.||.|.|..|.. ..  ..|.||..||..|...| .                              
DltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievk.............................

egmatasvdveerggeeikrndrkdehdiysstplaaslpnelndtltqsnqhqldqsitdtqsdlisfhtdskssqsdlkssqidpksdsessqafvmv
                                                                                                    
....................................................................................................

pnissDVPTVTMALISRRSRHRAGTRYLRRGVDNEGHVANFVETEMLLL-A---ATHLLSFIVVRGSVPVYWTQ-PGNRYRPLPIIEQTDEETAVAFERH
     .  .|...||||||..||||||||||.|..|.||||||||...      . ...||. .|||||..|.| ..  ..| . |..  |..  ||..|
.....skkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkH

FESQMNLYREQVIVNLINQSGRERIVSTAFEKQLLTL-----DCPSLTYVAFDFHHHCKVNQWHN
|..... |...|.|||....|||. .| |.|... .|     .   | |..||||..|| ....|
fkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfen
subfamily_Synaptojanin_pd Subfamily Synaptojanin 402-699 5.8e-72 234.2 In-house 144-431 (754) alignment 
Range on Protein: 402-699
Range on HMM: 144-431/754.0
VPTVTMALISRRSRHRAGTRYLRRGVDNEGHVANFVETEMLLLAATHLLSFIVVRGSVPVYWTQPGNRYRPLPI-IEQTDEETAVAFERHFESQMNLYRE
  .. .||||| |  |||||.  |||..||.|||||||| ..|.  ...||. .|||||..| ||| .     . ...  | .| ||.||.|.. . | |
akqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvillddkvtsfvqirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryGe

QVIVNLINQSGRERIVSTAFEKQLLTLDC-PSLTYVAFDFHHHCKVNQWHNINLLLSN-IEQYITRQKYFWIDNDEGSSgqplcYQNGVFRVNCMDCLDR
.|||||. . . |...|.||.|.| .    . . .| ||.|...| .. .... ||.. ..........|   ..| ..      |.|| ||||.|||||
vvivnllGskegeevlskafkkhlkasehakdvpfvkfdyhqkvkggkkeklekllkkqlklflesasfflskgkevek.....eqtGvlrvnClDCldr

TNVVQSVICKEFIQTALQKLGlIDPFTSLTGQFLRHYQELWANNGDTISRQYTGTDAMKGDLTrygqrrlYGVMKDGYNSAHRYLQSLFRDAYRQVVIDL
|| ||.|.  | ... |. |. ..  .|.  .| . ...|| .||| ||. |.|| |..|.          . .|||  | .| .|. | |. .|  |||
tnavqtvlglevlekqlealk.lsskesvvsrfeevfkslWsknGdeiskiyaGtgalegkak.......vsklkdgarsvartiqnnfldsskqeaidl

Q
 
l
subfamily_FIG4_pd Subfamily FIG4 392-701 4.5e-54 174.8 In-house 216-539 (569) alignment 
Range on Protein: 392-701
Range on HMM: 216-539/569.0
FVMVPNISSDVPTVTMALISRRSRHRAGTRYLRRGVDNEGHVANFVETEMLL-------LAATHLLSFIVVRGSVPVYWTQPGNRYRPLPIIEQTD-EET
||   .||    .....||.|||.. ||.|.|.|||.|.|.||| |||| ..       |.. .. ||. .|||||.||.|  ..  . | |.    .  
fvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqivheasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPf

AVAFERHFESQMNLYREQV-IVNLINQ---SGRERIVSTAFEKQLLTLD-----CPSLTYVAFDFHHHCKVNQWHNINLLLSNIEQYITRQKYFWIDNDE
| |  .||.. .. |   . |.||. .     ||.|....||. .  |.        |.|...|...  | .. . .. | .  |. .... .|   .| 
asaaalhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylneflPeekklkyiswdmaraskskeenvlevlekyaeksvkktGiflsapdl

GSSGqplcYQNGVFRVNCMDCLDRTNVVQSVICKEFIQTALQKLGLID-PFTSLTGQFLRHYQELWANNGDTISRQYTGTDAMKgDLTRYGQ-RRLYGVM
 |.      |.|. |.||.|||||||. | || |  ..  |..||.|| .  ..  .  |  .||. . |||.. ||.|.. ..  .  | . . .    
estk....iqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiidesklefdsdvvrlleelyedlGdtlalqygGsqlvn.tiktyrkiaqwssks

KDGYNSAHRYLQSLFRDAYRQVVIDLQQG
.|  .. .||    | || .|  |.|  |
rdiletlkryysnsfvdadkqdainlflG
subfamily_INPP5F_pd Subfamily INPP5F 155-288 2.2e-31 99.8 In-house 97-228 (951) alignment 
Range on Protein: 155-288
Range on HMM: 97-228/951.0
DEIK--METYAQDRREKDVKDIGKLEKKLKEALLQMFNGsRSFYFSYETDLTQSVQRKHDCGDANKLRKWervDERFFWNKNMLQDLLDNDKTIDK-WVL
| |.   ..|.|...||....  ||||.| | | ....  .|||.|...|||...|... . .......|   ||||||||..|.||.......|| ...
dlididssgylqlkeekeqneeeklekrlleelkkllsd.gsFYysldfDltntlqkrgleeksestddw...derFfWNkfllkdlinyrdkldkeflt

PVVQGYIEIKTIPIPsPDQLGIFLKKQQSHDTHVTTF
||.||..|.|.| |  . .. . |  ..|     |.|
pviqGfvetkeisie.klkvsltlisrrSrkragtrf
subfamily_SAC1_pd Subfamily SAC1 101-265 8.8e-26 81.5 In-house 7-152 (458) alignment 
Range on Protein: 101-265
Range on HMM: 7-152/458.0
SFGLIGKLQLLSNTgwYLLIITEAKSIGRLpnTDSDVFCIERVALISLSAEKSIDeikmeTYAQDRREKDVKDIgkLEKKLKeallqmfngSRSFYFSYE
 .|..| ..|||..  ||..||.....||.  . . .. .. | .|... .. ..     |  | ..||  ...  ||. ||         |..|||||.
iagilGiikLlsgk..ylivitkkeevgri..ngkviyrvadveiipvkknslsl.....teeqkkeekeylkl..lelvlk.........setfYfsyt

TDLTQSVQRKHDCGDAN--KLRKWERVDERFFWNKNMLQDLLDnDKTIDKWVLPVVQGYIEIKTIPI
 |||.|.||... . |.  .   .||.|||||||| .|.|| . .. .....|||..|.|.||.. .
ydltnslqrlekvtsaalkerslleradeRffwnkhlledlrk.epelesfilPvikGfikikelsl
hSac2 Inositol phosphatase 739-844 6.9e-17 50.1 Pfam-A 8-111 (115) alignment 
Range on Protein: 739-844
Range on HMM: 8-111/115.0
EREQLIADMIKTCRDNLFPNTSVPVKGWALIEPAGYSfvpTSEGEEDAVLLLCKerRHICVANYNNEFEQVACCIRIPLDRIERISIGPIGSIL---KTS
|||.|....|..|.  ..|.    ..||.|...   .    .. ||..||||..  ... |..|. | |.|    ||.|. |..|.|| . .     ..|
ereelreqaiekckklvlpddeeliggWlLvsidhsn...ktlteeervLLLTd..kalyvckYDfetekvtqferidLesikkieiGtysestlsedks

RRVYMRLFY
. . .|. |
enlglriny
Sac_COG5329 100-263 6.6e-16 48.6 In-house 60-218 (1070) alignment 
Range on Protein: 100-263
Range on HMM: 60-218/1070.0
HSFGLIGKLqlLSNTGWYLLIITEAKSIGRLPNTdSDVFCIERVALISLSAEKsIDEIKMETyaqdrrekDV--------KdigklekklkEALLQM--F
...|..| .    .   .| .||.... ..  .    .. |. |  |||  .|  |....|         |         .          . ....   
eiygvlGli..elegslflivitgkskvaqvipg.etiykilavdfislnnnk.wddeeies........deasteklrse..........hpcselkkL

NGSRSFYFSYETDLTQSVQRKhdcGDANKLRKWERVDERFFWNKNMLQDLLDND---KTIDK-------WVLPVVQGYIEIKTI
    |||||.  |.|...|..   .. ..  .... ||.|.||...|..|...    ....|       .  .|..|..|   |
lsngsFYfStdfditntLqkr...lkeelelsvdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfi
subfamily_FIG4_pd Subfamily FIG4 86-306 1.3e-15 47.7 In-house 55-264 (569) alignment 
Range on Protein: 86-306
Range on HMM: 55-264/569.0
SIDVQANSVPTKLCHSFGLIGKLQLLsnTGWYLLIITEAKSIGRLPNtdSDVFCIERVALISLSAEKSideiKMETYAQdrrekdvkdigklEKKLKEaL
|..  ...  .| . ..|..| ...|  .|.||...| .|... . .    .. || .|||... ...    | |....             |..... |
sleeanrdglekkvsayGilGfvrfl..egyylilvtkrkkvaviGg..haiykiedialikitedsk....ksekssd.............earylk.l

LQMFNGSRSFYFSYETDLTQSVQRKHDCGDANKLR-------------KWERVDERFFWNKNMLQDLLDNDKTiDKWVLPVVQGYIEIKTIPIPSpDQLG
..  . .. |||||  |||...|      | |. .             |  . .|.| ||...|. | |. ||  .|.| .. |... ..| .    .. 
fkdvdltknfyfsysydltrtlqtnlllsdsnrekekaedrvditieakkldanekfvWnnflleplkdtvkt.fdWlleiihGfvsqskisvlg.ksiy

IFLKKQQSHDTHVTTFLLGTPPKEGMATASVDVE
. |  ..|.    . ||     ..|  . .|. |
vtliarrsskfaGarflkrGvnnkGdvanevete
subfamily_Synaptojanin_pd Subfamily Synaptojanin 97-266 2.5e-15 47.0 In-house 2-143 (754) alignment 
Range on Protein: 97-266
Range on HMM: 2-143/754.0
KLCHSFGLIGKLQLLS--NTGWYLLIITEAKSIGRLPntDSDVFCIERVALISLSAEKSiDEikmetyaqdrrekdvkdigkleKKLKEaLLQMFNgSRS
|.. ..||.| |.| .  .|  .|...|..||.|...  |...| | .. |.||  | | ||                      ... | | .... | .
kivdaygllGvlrlnagdetlsflvlvtgcksvGkis..daeifkitstelvslrseas.de......................driie.lkklla.sgt

FYFSYETDLTQSVQRKHDCgdaNKLRKWERVDERFFWNKNMLQDLLDNDKTIDKWVLPVVQGYIEIKTIPIP
||||  .| ..... .  .   .. .. |  |.|||||. .   |   .   |.|.|.|. | .||.|. . 
fyfsssadsasrldlslsa...qrrkqeesednrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyag
subfamily_INPP5F_pd Subfamily INPP5F 101-162 1.6e-09 27.5 In-house 3-67 (951) alignment 
Range on Protein: 101-162
Range on HMM: 3-67/951.0
SFGLIGKLQLLSNTGWYLLIITEAKSIGRLPN----TDSDVFCIERVALISLSaEKSIDEIKMETY
..|.|||..|.|.. ..|.|..|.. .|.||.    ....|..||||| ..|| ||...|...|..
vygvigkillvseeerkLvivsessilgllpvqkkeskkevvaiervakldls.ekdskelekeec