Gene MINPP1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily MINPP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP196_AA protein Get Run
AqueP196_AA_88-515 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MINPP1_pd Subfamily MINPP1 236-516 9.9e-87 283.5 In-house 111-338 (420) alignment 
Range on Protein: 236-516
Range on HMM: 111-338/420.0
YSGLFDEVYSPDSFSFASTHKKRCVKSALSFAEGLfdgldlSNGGELMNTALTIYAQSIGLQIDDRSLRFFDNCKEYTNKSKRNELNTKLEvflrkvayv
.  ||.|||.|||||||||.|||.|||| .|||||      |..||.......|..|.|. |..|..|||||.||.|.||.|.||||.| |         
fpalfeevynpdsfsfastakkRtvksaqaFaeGL......setgevlgdefnivlqeiseqesdklLrffdsCkkyknkvkknelnlkee.........

sleavlNEFLFSDAISKALREIQQQIDESKRFWIINEHELLDMYQICAMETANFGHSNV-YSLkeaaqmafsFETDPLalvqlkgglrklggimyeIEFR
      .|||.|....|||.||.....|.|......|... ||..|||.|.|..|.||| .||         ||.|.|                  .|..
......eefleskelqkaleeiakrlneekklleltekdiedmfeiCayelaikgisnvWcsl.........fekdel..................lele

FMSHLSNVYEckshqasiiHSHGHTINWSISCHLINDIINSLSPSNPAKVT---LRFAHAETLVPLLSALSLYKDDLHLLPSNYH
....|.|.|.         ...|..||.||||.|.|||...|..|...|..   |||||||||.||||.|.||||. .|...|||
YledLknyyk.........egyGyeinysiscpLlndivkllksseeqkqkssslrFaHaetllpllsllGlykDeekLtannyh
0048439 Phosphoglycerate mutase-like 112-512 4e-29 95.2 In-house 5-311 (391) alignment 
Range on Protein: 112-512
Range on HMM: 5-311/391.0
NGCTASKLYIIFRHGTRYPGKNHIRRFDSISEKlsnlsrssgvvnklrgwiN-PFLIEEHSHLSSIGRKELYCLAKRFKQSKrsimclrgarssyhhpcr
.||.  .....||||.|.| .. . ..| . .|                  . |.     ..|.  ||..|| | .|. .                    
agcelkqvqvlfRHGaRtPtssypnkldpllnk..................llpngpcglgeLTplGreqlyelGrrlrkrY..................

sfrsheqalsdgrremilddfnmfMYSGLFDEVY--SPDSFSFASTHKKRCVKSALSFAEGLFDGLDLSnggeLMNTALTIYAQSIGLQIddrSLRFFDN
                          .||... |  .|. . . |. . |...|| .|..|||..|.|.    . ..  .. ....   .     .....
........................vdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplglt....vilvivvesedpllnpl...pintcpl

CKEYTNKSKRNELNTKLEVFLR----------------KvayvsleavlneflfsdaiskalreiqqqideskrfwiineHELLDMYQICAMETANFGH-
.. ..... ...|.  .                                                                ..|.....|| ||| .|. 
ledlllldalsalprfylseilerlaevlnrvlglnlta.........................................edvlslfdlcaketaalgsl

----SNVYSLKEAAQMAFSFETDPLALVQLKgglrkLGGIMYEIEFRFMSHLSNVyeckshQASIIHSHGhTINWSISCHLINDIINSL--SPSNPAKVT
    |.. .| .   . ..     | | .       .......  ..... | |       .   ....|  |.  ... |.|.|.. |  . ... |..
lklssplcdlftlydtllyeyahglplpewl.....tdellspellkqladlvne......lyyyltgsg.eiaklaggpllneilddlvangpsdpkly

LRFAHAETLVPLLSALSLYKDDLHLLP
| ||| .|...||||| |..|.|.| .
lyfaHdttiaallsaLglfndtlplpa
0047369 Phosphoglycerate mutase-like 110-509 1.8e-26 86.4 In-house 38-351 (438) alignment 
Range on Protein: 110-509
Range on HMM: 38-351/438.0
SLNGCTASKLYIIFRHGTRYPGKNHIRRFDSISEKLSNLSRSSGvvnklrgwiN-------PFLIEEHSHLSSIGRKELYCLAKRFKQSKrsimclrgar
  .||.  .....||||.|.| |. ....  . |.| | . . .         .          .    .|.  ||...| | ||. .            
vpegcelkqvqvlfRHGaRtPtksklkkleplwellenattyps.........gplsflndwlgpcgagqLTplGreqayelGkrlrkrY..........

ssyhhpcrsfrsheQALsdgrremilddfnmfmysglfdevySPDSF-SFASTHKKRCVKSALSFAEGLFDGldlSNGGELMNTALTIYAQSIGLQIDDR
              . |                         .|. .  . |. . |...|| .|. |||..   .  ||| .  .. .   .    || 
..............glL.........................npedvlyvrssdvdRtlqSAqaflaGlfpp...egtgelapilwqpipihtipesddf

SLR--FFDNCKEYTNKskrnelntklevflrkvayvsleavLNEFLFSDAISKA-LREIQQQIDESKRFWIINEHELLDMYQICAMETANFghsnvyslk
 |.  ..|.|. . .                          |.||| ||   .  |..|.. . .   .. ..   .||.|..||..|...         
llnllpsdscpafdel.........................lkeflasdeflelllkdilkrlkkllpglnltpsdvldlydlcaydtlan.........

eaaqmafsfetdplalvqlkgglrklggimyeieF------------RFMSHLSNVYECKSHQASIIHSHGHTINWSISCHLINDIINSLSPSN------
                                                ....| ..  . . .   .. .|. ..  ... |.|.|.. |          
..................................gyaglplspfcslftpeelevleyladlefyylygygnelaklaggpllneilarledaingkstn

--------------PAKVTLRFAHAETLVPLLSALSLYKDDLH
              . |..| ||| .|...||||| |..|...
lnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwp
0046349 Phosphoglycerate mutase-like 113-505 2e-24 79.6 In-house 4-317 (409) alignment 
Range on Protein: 113-505
Range on HMM: 4-317/409.0
GCTASKLYIIFRHGTRYPGKNhirrfdsiseklsnlsrsSGVVNKLRGWINPFLIEEHSHLSSIGRKELYCLAKRFKQS----Krsimclrgarssyhhp
||.  .....||||.|.| |.                   .  ..  |. ...     ..|.  ||...| | ||...     .                
gceLkqvqvlfRHGaRtPtkk..................lsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlg................

crsfrsheqalsdgrremilddfnmfmysgLFDEV--YSPDSFSFASTHKKRCVKSALSFAEGLFDGLDLSNG-------------GELMNTALtiyaQS
                              |...   |.|| . . |. . |...|| .|..|||..|. .               .  ..|.     .|
..............................LlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvp....is

IGLQIDDRSLRFFDNCKEYTNKSKRNElntKL-EVFLRKVAYVSLEA--VLNEFlfSDAISKALREIQQQIDeskRFWIINEHELLD-MYQICAMETAN-
..  .|| .|.....|. . .  |.|    |. . .|. ..  .|    .|.|.   | ..|. ........    . ... ... . .| ....|||. 
eddalddtllppdslcpaldkllkenl...kslsevleflvdealldlelldet..kdllkklaerlnselp...glnltdpldvasllydtllyetahg

FGHsnvyslkeaaqmafsfetdplalvqlkgglrklggimyeIEF---RFMSHLSNVYECKSHQASIIHSHGhTINWSISCHLINDIINSLSPSN-----
..                                         ..    ....| ..... . .  .....|  ..  ... |.|.|.. |         
lpl.......................................ppwcdlftpeelkvlayladleyyylygsg.elaklaggpllneilarledaisgknp

-----PAKVTLRFAHAETLVPLLSALSLYK
     . |..| ||| .|...||||| |..
vtfpldlklylyfaHdttiaallsaLglfd
0053031 Phosphoglycerate mutase-like 119-508 4.1e-23 75.3 In-house 6-275 (342) alignment 
Range on Protein: 119-508
Range on HMM: 6-275/342.0
LYIIFRHGTRYPgknhirrfdsiseklsnlsrssGVVNKLRGWINPFLIEEHSHLSSIGRKELYCLAKRFKQSKrsimclrgarssyhhpcrsfrsheqa
.....|||.|.|                       .  .|  ....|    ...|.  ||...| | .|...                            
vivlvRHGaRtP......................lskgpldplnewfypcgageLTplGreqayelGrrlrkrY..........................

lsdgrremilddfnmfmySGLFDEVYSPDSFSFASTHKKRCVKSALSFAEGLFDGLDLSNGgELMNTALTIYAQSIGLQIdDRSLRF-FDNCKEYTNKSK
                  .||... |.|| . . |. . |...|| .|..|||.. . .   . ...   |  ...     |  |.. .|.|. . .  |
..................lgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpil.npllgwqpipihtepess.dalllpnydpcpafdkllk

RNELNTKLEVFLRkvAYVSLEAVLNEFL----------FSDAISKALREIQQQIDESKRFWIINEHELLDMYQICAMETANFGHSNvyslkeaaqmafsf
..  .  .. .|    | .| . |.. |          .||  .  | |...  . .. . . .  ||. .| .  .   ..|..|              
ealaseevkelle..rylellqklskglgltlsdlldlvsdlydlllyelahglplppwctlftleelkalyaldllyyyglgpgn..............

etdplalvqlkgglrklggimyeiefrfmshlsnvyeckshqasiihshghTINWSISCHLINDIINSLSP----SNPAKVTLRFAHAETLVPLLSALSL
                                                    ... ... |.|.|.. |      ... |..| ||| .|...||||| |
...................................................elaklaggpllneilarleekisgpldlklylyfahdttiaallsaLgl

YKDDL
..|.|
fddql
0049226 Phosphoglycerate mutase-like 119-508 7.5e-23 74.4 In-house 6-275 (342) alignment 
Range on Protein: 119-508
Range on HMM: 6-275/342.0
LYIIFRHGTRYPgknhirrfdsiseklsnlsrssGVVNKLRGWINPFLIEEHSHLSSIGRKELYCLAKRFKQSKrsimclrgarssyhhpcrsfrsheqa
.....|||.|.|                       . ..|  . ..|    ...|.  ||...| |..|...                            
vqvliRHGdRtP......................lakgpldflnewfwgcglgeLTplGreqayelGrrlrkrY..........................

lsdgrremilddfnmfmySGLFDEVYSPDSFSFASTHKKRCVKSALSFAEGLFDGLDLSNGGELMNtaltiyAQSIGLQ----IDDRSLRF-FDNCKEYT
                   ||... |.|| . . |. . |...|| .|. |||..   .    |..       | | ..      |  |.. .|.|... 
..................lgllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvplld......wqpipiitepesndtllllpydscpnfd

NKSKRNELNTKLEVFLRKVAYvsLEAVLNEFLFSDaiskalreiqqqideskrfwIINEHELLD-MYQICAMETAnfghsnvyslkeaaqmafsfetdpl
.  |..  .. .. || . .   |   | . |  .                    ... ... | .|.....|.|                         
kllkellkseevqlfleeild..llkklskllgln....................lstlsdvadtlydlllyela.........................

alvqLKGGLRKLGGIMYEIEFRFMSHLSNVYECKShqasiihSHGHTINWSISCHLINDIINSLSP----SNPAKVTLRFAHAETLVPLLSALSLYKDDL
     . .| .. .. .  |.. .. |.. |.          ..|. |.. ... |.|.|.. |.     ....|..| ||| .|...||||| |..|.|
....hglplppwcslftleelkalyaldllyyygi.......gygeeiarlaggpllneilarleeaiegpsdlklylyfahdttiaallsalglfddql
0048946 Phosphoglycerate mutase-like 235-515 1.6e-22 73.1 In-house 123-330 (447) alignment 
Range on Protein: 235-515
Range on HMM: 123-330/447.0
MYSGLFDevySPDSFSFASTHKKRCVKSALSFAEGLFDGLdlsnggelMNTALTIYAQSIGLQIDDRSLRFfdNCKEYTnkskrnelntklevflrkvay
.|.||..   .|. . . |. . |...||..|. |||.          ...  ..    .     | .|..  .|. .                      
rYlgllp...npseiyvrssdvdRtlqSaqaflaGlfppe........pplgyqpipihtvpssndnlllp..sCpafk.....................

vslEAVLNEFLfsDAISKALREIQQQIDESKRFWIINEHELLDMYQICAMETANFGHSNVYSL---KEAAQMAFSFETdplalvqlkgglrklggimyei
   | . .|.   . ... |.|..... .    . .. . . |.|.....||| .|.|.  ||   .|. ....                          
...ellkkela..eelkellkellerlkkllgglnltlsdvydlydlllyetaihglsplcslftpeelevleyladl......................

efrfmshlsnvyeckshQASIIHSHGHTINWSISCHLINDIINSLSP--SNPAKVTLRFAHAETLVPLLSALSLYKDDLHLLPSNY
                 .   ....|. ..  ... |.|.|.. |.   |.  |..| ||| .|...||||| |..|.| | ..|.
.................efyyeygygdelarlaggpllneilarledaisgdsklylyfaHdttiaallsaLglfddelplpadnl
0049059 Phosphoglycerate mutase-like 235-515 1e-19 63.9 In-house 116-355 (435) alignment 
Range on Protein: 235-515
Range on HMM: 116-355/435.0
MYSGLfdevYSPDSFSFASTHKKRCVKSALSFAEGLFDGLdlSNGGELMNT-ALTIYAQSIGLQIDDRSLrFFDNCKEYTNKSKRNElntklevflrkva
.|..|    |.|| . . |. . |...|| .|..|||..   ..|  |.|     .. .      |. .| ..|.|. . . .|..              
rYgfL....ynpdevyvrssdvdRtlqSaqaflaGlfppe..ilgsqllnplnvyqpvpietvdsdndtl.pydscpafdellkell.............

yvsleavlneflFSDAISKA-LREIQQQIDESKRFWIINEHELLDMYQICAMetanfghsnvyslkeaaqmafsfetDPLALVQLKGGLRKLGGIMYEIE
             ||   .  |..|.. ..|  ..  .. . .||.| .|..                         | |.| .  |   .. ....| |
............asdeflelflerilkllqellpglgltpsdvldlydlcky.........................dtlllgyahglplpfcslfteee

FRFMSHLSNVYEckshqaSIIHSHGHTINWSISCHLINDIINSLSPS----N----------------PAKVTLRFAHAETLVPLLSALSLYKDDLHLLP
.. .. |....         ....|. |.  ... |.|.|.. |       .                . |..| ||| .|..|||||| |..|.|.| .
levleyladlef......yylygygdeiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpa

SNY
.|.
dnt
subfamily_MINPP1_pd Subfamily MINPP1 92-190 6.9e-17 53.4 In-house 6-109 (420) alignment 
Range on Protein: 92-190
Range on HMM: 6-109/420.0
FSSKTR-YSFTPFINEDRMSLNGCTASKLYIIFRHGTRYPGKNHIRRFDSISEKLSNLSRSSG----VVNKLRGWINPFLIEEHSHLSSIGRKELYCLAK
..|||. ||... ....... .||...||.||.||||||| |..|..  .  ||..| |..      ..|.   .  .. .|  ..|   |..||. |||
lgsktpyysvkanydikkeaeegCklvklqiiaRHGtRypskskikkiqetlekiknyseqldgklsilnedlesnleyetelekslvaqgqeeleelak

RFKQ
|...
rlar
His_Phos_2 Histidine phosphatase superfamily (branch 2) 235-506 2.9e-16 52.2 Pfam-A 81-313 (347) alignment 
Range on Protein: 235-506
Range on HMM: 81-313/347.0
MYSGLFDEVYSPDSFSFASTHKKRCVKSALSFAEGLFDGLD-----LSNGGELMNTALTIYAQSIGLQIDDRSLRFFDNCKEYTN------KSKRNELNT
.| ||... . .. . . |. ..|...|| .||.||..          .     ..|  .. . .  . ..  ..  ..|.....      | .....| 
rYpgllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnk

KLEVFLRKVAyVSLEAV---LNEFLFSDAISKALREIQQQI--DESKRFWIINE--HELLDMYQicametanfghsnvyslkeaaqmafsfetdplalvq
  .|.  ..|  .|.|.    . .|| .  .|  ||  ..   | ||   . ..  ...|.. |                                    
lkkvmdenla.krlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrq....................................

lkgglrklggimyeiefrfMSHLSNVYECKSHQASIIHSHGHTINWSISCHLINDIINSLsPSNPAKVTLRFAHAETLVPLLSALSLYKD
                   ...|.. | .   . ..    |. .   .  .. .|. ..  ||. ||. | |.| .....||.|| |...
...................ledleelyklygigdeeklkigllllnpllkkilsdleetq.psrhaklrlyfthDshiytllnaLgleek
His_Phos_2 Histidine phosphatase superfamily (branch 2) 235-506 2.9e-16 52.2 In-house 81-313 (347) alignment 
Range on Protein: 235-506
Range on HMM: 81-313/347.0
MYSGLFDEVYSPDSFSFASTHKKRCVKSALSFAEGLFDGLD-----LSNGGELMNTALTIYAQSIGLQIDDRSLRFFDNCKEYTN------KSKRNELNT
.| ||... . .. . . |. ..|...|| .||.||..          .     ..|  .. . .  . ..  ..  ..|.....      | .....| 
rYpgllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnk

KLEVFLRKVAyVSLEAV---LNEFLFSDAISKALREIQQQI--DESKRFWIINE--HELLDMYQicametanfghsnvyslkeaaqmafsfetdplalvq
  .|.  ..|  .|.|.    . .|| .  .|  ||  ..   | ||   . ..  ...|.. |                                    
lkkvmdenla.krlsalctgednllfkerweklfreffeeekfdiskipelydtmkydalhnrq....................................

lkgglrklggimyeiefrfMSHLSNVYECKSHQASIIHSHGHTINWSISCHLINDIINSLsPSNPAKVTLRFAHAETLVPLLSALSLYKD
                   ...|.. | .   . ..    |. .   .  .. .|. ..  ||. ||. | |.| .....||.|| |...
...................ledleelyklygigdeeklkigllllnpllkkilsdleetq.psrhaklrlyfthDshiytllnaLgleek
subfamily_ACP2_pd Subfamily ACP2 237-508 1.2e-10 33.5 In-house 67-288 (361) alignment 
Range on Protein: 237-508
Range on HMM: 67-288/361.0
SGLFDEVYSPDSFSFASTHKKRCVKSALSFAEGLFDGldlsNGGELMNTALT--IYAQSIGLQIDDRSLRFFDNCKEYTNKskRNELNTKLEVFlrkvAY
....|. |.|. . . |. . |.. || |.. |||.     ..|   ..       .  .  . .|  || . ||. | .    .|.... ||     ..
tkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfpp....etgvdypdeqeWqpvPvhtvseeedlllrakknCprydel..lqeakespevk....kl

VSLEAVlneflFSDAISKALReiqQQIDESkRFWIINEHELL-DMYQICaMETANFGHSN-VYSLKEAAQMAFSFETDPLALVQLKGGLRKLGGIMYEIE
.. ..      . ...|.      ..||.. .|. ...  .   .|  . ..  .. . .    |.| |......|..  . .. .    . | .. |. 
leenke.....lleklsestg...edidle.nfyqlsdtlicerkyane.lnlpewandelfekleeladkvkeaefglnnektrelkklrgGpllnell

FRFMSHLSNVYECKShqasiihshghtinwsischlindiinslspsnpAKVTLRFAHAETLVPLLSALSLYKDDL
 .. ..|..  . |.                                   |..|  || .||..||.||...... 
enmkeklkceekkkk..................................lklflYSaHDttlaalLeaLgifekka
0049059 Phosphoglycerate mutase-like 95-190 1.1e-09 30.8 In-house 21-115 (435) alignment 
Range on Protein: 95-190
Range on HMM: 21-115/435.0
KTRYSFTPFINEDRM-SLNGCTASKLYIIFRHGTRYPGKNHIRRFDSISEKLSNLSRSSGvvNKLRGWINPFLIEEHSHLSSIGRKELYCLAKRFKQ
...|   | .... .   .||.  .. ..||||.|.| .. |.... . ||| .|... .  ..|  . .....  ...|.  ||...| |.||. .
lspyfsapgvfgisldvpegcelkqvqvlfRHGaRtPtsklikklealwekllslltypn..gplsflndwnyplgageLTplGreqayelGkrlrk
0048946 Phosphoglycerate mutase-like 89-190 7e-09 28.2 In-house 14-122 (447) alignment 
Range on Protein: 89-190
Range on HMM: 14-122/447.0
SVSFSSKTRYSFTPFINEDRMSLNGCTASKLYIIFRHGTRYPGKNHIRRFDSISEKLSNLSR-----SSGVVNKLR-GWINPFLIEE-HSHLSSIGRKEL
.  .. .. | . |  . .    .||.  .....||||.|.| |. .... .. ..| | .      . ...|     . |..| .   . |.  ||..|
llhlgtlspyfsvpgygipepvpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwpcglgqLTplGreql

YCLAKRFKQ
| | ||...
yelGkrlrk