Gene B0207.1 in Caenorhabditis elegans

Synonym: CELE_B0207.1, B0207.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf8
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP008_AA protein Get Run
CeleP008_AA_255-523 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 253-539 2.3e-160 527.3 In-house 1-288 (288) alignment 
Range on Protein: 253-539
Range on HMM: 1-288/288.0
KKKEIINAWIRHVLSIGIEGLKKEYQDSPNGGSIRSAQVFVANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVSSAKY-RRIICAQAPLKGTIEEFWR
||||.||||||.||.|..|||||||.||||..||.....|.|||||.||.|.|.||.||||..|||||||.||.|||||| ||.|||||||.|||||.|.
kkkevinawirlvlqiaveglkkeyrdspneasidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWk

MILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKFCNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIF
|.|.|.|||||||||..|.||||||.|||||||...|||..|...|....||||....|||||..||.|.|.||..|...|.|.||||.|.|||.||...
mllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl

RSHQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYTKFLK
.|.||||..|.||||||||||.||||||..||..||.|||.|...||||||||||||||||.|||||||.|..|||.|.|.|..|...
kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlredfvklae
0036941 (Phosphotyrosine protein) phosphatases II 269-534 2.2e-75 249.0 In-house 11-289 (297) alignment 
Range on Protein: 269-534
Range on HMM: 11-289/297.0
GIEGLKKEYQDSPNGGSIRS--AQVFVANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVSSAK-YRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLC
.. .|.||... ..   . |  .. ...| ..|||..|...| ||||.||... ||.|. |.  .  |..|..|.||..|.|.||||..  .|. ||||.
flalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

EIIELGKEKSANYFPSKLGQAMRIGKFcNITKVQHDD-IDKVISMSLLRITR-EGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRS------HQKP
| .|||.|| | |.|.. |. .  |.|  .| .  .  ... . .  |..|  ...|. .|.| |...|||||||||. | |.... .|.       ..|
elvelgrekcaqywpleegesltygdf.tvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

ILIHCSAGVGRTGTLALILIALQTLR---SVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDY
.|.||||||||.||.... ..|| |.         |  ..  ||| |. |.||..||.|.....||.|  |.. .. ...
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
0050432 (Phosphotyrosine protein) phosphatases II 267-528 1.6e-74 246.3 In-house 38-305 (308) alignment 
Range on Protein: 267-528
Range on HMM: 38-305/308.0
SIGIEGLKKEYQDSPNGGSIRS--AQVFVANPTRNRYTNIPCCDATRVKIdDDPDFYIHANIVSSA---KYRRIICAQAPLKGTIEEFWRMILSSGVEYI
 ... .|..|... ..   ...  .  ...| ..|||..|...| .|||. |... ||.|. |.     . |..|..|.||..|.| ||||.   .|..|
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvI

VMLCEIIELGKEKSANYFPSKLG-QAMRIGKFC-NITKVQHddIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSH--QKP
|||....| |.|| | |.|..|| . ...|||. .......   | ..   |     ...|  .|.| |..||||||||.|  . |..|.. |..  ..|
vmLtklvengrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggp

ILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYN
|..|||||||||||.......|. |.      .  .. .||| |  ..||..||||..|..||||  |.. 
ivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
0040438 (Phosphotyrosine protein) phosphatases II 271-537 5.9e-72 237.9 In-house 18-288 (317) alignment 
Range on Protein: 271-537
Range on HMM: 18-288/317.0
EGLKKEYQDSPNGGS-IRSAQVFVANPTRNRYTNIPCCDATRVKIDDDP----DFYIHANIVSSAK-YRRIICAQAPLKGTIEEFWRMILSSGVEYIVML
 .|..|..| ..     .|   ...|. .|||..|...|..|||. ...    . ||.|. |.  .  |..|..|.||..|.| ||||.   ||..||||
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmL

CEIIELGKEKSANYFPSklGQAMRIGKFCnITKVQHDDiDKVISMSLLRITR-EGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSH----QKPIL
.|  |||.||.| |.|.  |. . .|.|. .| .. .  .. | .  |...  ...|...|.| |...|||||||.|  . |..|.. |..    ..|.|
teleelgrekcaqYwpl..getltygdft.vtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvl

IHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLvqkKYNVNRDDYTKF
.|||||||||||.......|. |.   .  .   . .||| | .|.||..|| |.....||||   |..... .....
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl...krkltlepasel
0039614 (Phosphotyrosine protein) phosphatases II 251-525 9.9e-72 237.2 In-house 12-292 (297) alignment 
Range on Protein: 251-525
Range on HMM: 12-292/297.0
GKKKKEIINAWIRHVLSIGIEGLKKEYQDSPNGGSIRSAQVFVANPTRNRYTNIPCCDATRVKIDDDPDF-----YIHANIVSSAK--YRRIICAQAPLK
  .. .........    .. .|..|... ..    .|   ...| ..|||..|...| .|||. . ...     ||.|. |.  .   |..|..|.||.
ipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlp

GTIEEFWRMILSSGVEYIVMLCEIIELGKeKSANYFPSKLGqamRIGKFC-NITKVQHddiDKVISMSLLRITReGQEPVFVKHVHWHNWPDHGVPESYM
.|.| ||||.   ||..||||.. .|||. | | |.|.. |   . |.|. . .||.|   .. . .  |..|. ..|. .|.|.....|||||||.|  
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh...ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppsle

SPLHLLNIFRS------HQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQK
. |..|.. |.       ..|.|.|||||||||||.......|. |..     .   . .||| | .|.||. || |.....||.| .|
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
DSPc_SM00195 290-522 4.2e-71 234.7 In-house 21-262 (263) alignment 
Range on Protein: 290-522
Range on HMM: 21-262/263.0
QVFVANPTRNRYTNIPCCDATRVKIDDD----PDFYIHANIVSSA-KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLG
. . .| ..|||.||...| ||||....    .. ||.||... | | ...|..|.||. |.|.||||..  .|..||||.|  | |||| ..|.|.. |
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesg

QAMRIGKFcNITKVQHDDIDKVISMSLLRITREGQ-EPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQK----PILIHCSAGVGRTGTLALILIAL
. ...||. ... |. .  .. | .  |..| ||. |. .|......||||||||.| .| |.||. ......    ||..|||||||||||...| |.|
gketfgki.svklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

QTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
. |.. .   |  ....||..|....||..||||.....|||.
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 290-522 4.2e-71 234.7 In-house 21-262 (263) alignment 
Range on Protein: 290-522
Range on HMM: 21-262/263.0
QVFVANPTRNRYTNIPCCDATRVKIDDD----PDFYIHANIVSSA-KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLG
. . .| ..|||.||...| ||||....    .. ||.||... | | ...|..|.||. |.|.||||..  .|..||||.|  | |||| ..|.|.. |
aekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesg

QAMRIGKFcNITKVQHDDIDKVISMSLLRITREGQ-EPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQK----PILIHCSAGVGRTGTLALILIAL
. ...||. ... |. .  .. | .  |..| ||. |. .|......||||||||.| .| |.||. ......    ||..|||||||||||...| |.|
gketfgki.svklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

QTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
. |.. .   |  ....||..|....||..||||.....|||.
skleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0046845 (Phosphotyrosine protein) phosphatases II 273-528 1.4e-70 233.3 In-house 2-280 (284) alignment 
Range on Protein: 273-528
Range on HMM: 2-280/284.0
LKKEYQDSPNGGSIR----SAQVFVANPTRNRYTNIPCCDATRVKIDD-----DPDFYIHANIVSS------AKYRRIICAQAPLKGTIEEFWRMILSSG
|..|..  ..    .    |. ....| ..|||..|.. | .|||..      . . ||.|. |.        . ...|..|.||..|.|.||||..  .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VEYIVMLCEIIELGKEKSANYFPSKlGQAMRIGKFCNITKVQHDdiDKVISMSLLRITRE--GQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSH-
|..||||.|..| |.|| | |.|.. |. ...|.|.  ..  .   .. . .  |..|..  ..|...|.| |...|||||||.|  . |..|.. |.. 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

-----QKPILIHCSAGVGRTGTLALILIALQTLRSVD---FSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYN
     ..||..|||||||||||.... ..|. |.  .      .  .. |||| |. ..||..||.||....||||  |.. 
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0047943 (Phosphotyrosine protein) phosphatases II 272-522 4.1e-70 231.7 In-house 13-272 (273) alignment 
Range on Protein: 272-522
Range on HMM: 13-272/273.0
GLKKEYQDSPNGGSIR--SAQVFVANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVSS-AKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEII
.|..|... ..   .   |. ....| ..|||..|...| .|||..|... ||.|. |.   . |..|..|.||..|.|.||||.   .|..||||.|..
llleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelv

ELGKEKSANYFPSKLGQ-AMRIGKFcNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRS------HQKPILIH
|||.|| | |.|.. |.  .. |||  .| . ..  | ..   |     . .|. .|.|.|...|||||||.|. | |..... |.      ...|...|
elgrekcaqYwpleggelsltygkf.tvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVH

CSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
||||||||||.......|. |.      .  .. .||. |. ..||. ||.|.....||||
CsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 269-522 1.9e-69 229.7 In-house 21-286 (288) alignment 
Range on Protein: 269-522
Range on HMM: 21-286/288.0
GIEGLKKEYQDSPNGGSIR--SAQVFVANPTRNRYTNIPCCDATRVKIDD----DPDFYIHANIVSS-AKYRRIICAQAPLKGTIEEFWRMILSSGVEYI
|. ||..|... ..    .  || ....| ..|||..|...| .|||. .    ... ||.|. ..   . |. |..|.||..|.|.||||.   .|..|
gltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvI

VMLCEIIELGKEKSANYFPSklGQAMRIGKFCnITKVQHDDIDKVISMSLLRITR----EGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSH---
|||....|||.||.| |.|.  |. . .|... .| .  .  |...   |          ..|. .|.| |..||||||||.|  . |..|...|..   
vmltklvelgrekcaqYwpl..ggsltygdit.vtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalas

-QKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
 ..|...|||||||||||.......|. |.      .  .. |||| |. ..||..||.||....||||
gggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
Y_phosphatase Protein-tyrosine phosphatase 295-520 2.4e-68 225.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 295-520
Range on HMM: 1-235/235.0
NPTRNRYTNIPCCDATRVKI--DDDPDFYIHANIV-SSAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGK
| ..|||..|...| ||||.  ...|  ||.||.| .  . ...|..|.||| |||.||||..   |..||||..  | |.|| |.|.|.. .. .. |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

FCNITKVQHDDIDKVISMSLLRITREGQE--PVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQ----KPILIHCSAGVGRTGTLALILIALQTLRSV
..  .|..  ...| . .. |... ...|  .  ||..|..||||||||||. | |.|.. .....    .|...|||||||||||.... |.|. |.. 
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

DFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLE
.   .  .  .||..|....|.. || |.....||
eevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 295-520 2.4e-68 225.4 In-house 1-235 (235) alignment 
Range on Protein: 295-520
Range on HMM: 1-235/235.0
NPTRNRYTNIPCCDATRVKI--DDDPDFYIHANIV-SSAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGK
| ..|||..|...| ||||.  ...|  ||.||.| .  . ...|..|.||| |||.||||..   |..||||..  | |.|| |.|.|.. .. .. |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

FCNITKVQHDDIDKVISMSLLRITREGQE--PVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQ----KPILIHCSAGVGRTGTLALILIALQTLRSV
..  .|..  ...| . .. |... ...|  .  ||..|..||||||||||. | |.|.. .....    .|...|||||||||||.... |.|. |.. 
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

DFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLE
.   .  .  .||..|....|.. || |.....||
eevdvlqivkelRkqRpgmvqsleqYiflykaile
0045450 (Phosphotyrosine protein) phosphatases II 249-524 6.3e-68 225.1 In-house 5-306 (307) alignment 
Range on Protein: 249-524
Range on HMM: 5-306/307.0
FSGKKKKEIINAWIRHVLSIGIEGLKKEYQDSPNGGS----IRSAQVFVANPTRNRYTNIPCCDATRVKIDD-----DPDFYIHANIVSSA---------
.| . . ...  ...  |  ...||.||... ..        .|.  ...| ..|||..|...| ||||. .     ... ||.|. |            
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKlGQAMRIGKFCNITKVQHDdiDKVISMSLLRITR--EGQEPVFVKHVH
. |..|..|.||..|.|.||||.   ||..||||.| .|||.|| | |.|.. |. . .|.|.  ..  .   .. . .  |..|.  . .|. .|.| |
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfh

WHNWPDHGVPESYMSPLHLLNIFRS------HQKPILIHCSAGVGRTGTLALILIALQTLRSVDF---SGIRPLFTRLREERFKAIQTEMQYLFVHRCVL
...|||||||.|  . |..... |.       ..|.|.|||||||||||.......|. |..        ..  . .||| | .|.|.. || |.....|
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

EYLVQ
|.| .
elllk
0043336 (Phosphotyrosine protein) phosphatases II 285-522 4.4e-67 221.8 In-house 35-277 (278) alignment 
Range on Protein: 285-522
Range on HMM: 35-277/278.0
SIRSAQVFVANPTRNRYTNIPCCDATRVKIDDDP----DFYIHANIVSSAK-YRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYF
  .|   ...| ..|||..|...| .|||.....    . ||.|. |.  .  |..|..|.||..|.| ||||.   ||. ||||.|  |||..|.| |.
dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYw

PsklGQAMRIGKFcNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRS----HQKPILIHCSAGVGRTGTLALI
|   |. ...|.|  .| .  .  | ..   |    .   |. .| |.|...|||||||||  . |..|...|.     ..|.|.|||||||||||....
p...ggsltygdf.tvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfial

LIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
...|. |..  .  .   . .||| |..|.||..|| |.....||||
yllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 257-529 9.6e-63 207.0 In-house 2-284 (307) alignment 
Range on Protein: 257-529
Range on HMM: 2-284/307.0
IINAWIRHVLSIGIEGLKKEYQDSPNGGSI-RSAQVFVANPTRNRYTNIPCCDATRV--KIDDDPDFYIHANIVS-SAKYRRIICAQAPLKGTIEEFWRM
... |... |  |.. |. |..   .      ... | ||. .|||....| | .|.  |.|     ||||| .  . | ...|||| ||. |. .|| |
vvkpwvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwam

ILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKFCNITKVQHDD------IDKVISMSLLRITReGQEPVFVKHVHWHNWPDHGVPESYMSPLH
..   || ..|||..|||.| |  .|.| . || .  |.  |   |.          ...| .. |..   .|.   ..|. |.||||.|||.  .. . 
aiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltain

LLNIFRSHQKPILIHCSAGVGRTGTL-ALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNV
||.  | .. |...||||||||.||. |. |.  . .. ..   .. |   ||..|  |||||.|||..|| .|||....  . 
lleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyket
0040439 (Phosphotyrosine protein) phosphatases II 290-523 1.8e-62 206.5 In-house 6-247 (249) alignment 
Range on Protein: 290-523
Range on HMM: 6-247/249.0
QVFVANPTRNRYTNIPCCDATRVKIDD----DPDFYIHANIVSSAK-YRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSklG
  ...|. .|||..|...| .|||. .     .. ||.|. ..  .  ||.|..|.||..|.| ||||.   |...||||..  |||.|| | |.|.  |
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..g

QAMRIGKFcNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRS------HQKPILIHCSAGVGRTGTLALILIA
. . .|.|  .| .. .  |...   |     . .|.. |.|.....|||||||.|  . | .... |.       ..|.|.|||||||||||.......
gsleygdf.tvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

LQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLV
|. |.      .   .  ||. |..|.|.. || |.....||.| 
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0045098 (Phosphotyrosine protein) phosphatases II 288-526 2e-62 206.4 In-house 26-276 (278) alignment 
Range on Protein: 288-526
Range on HMM: 26-276/278.0
SAQVFVANPTRNRYTNIPCCDATRVKidddpDfYIHANIVSSAkYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSklGQAM
.  ... |  .|||..|...| .|||     | ||.|. ...   .. |..|.||. |.. ||||. . |...||||.| .|||.|| | |.|.  |. .
tpalylgnldknRykdilpydhsrVk.....d.YINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsl

RIGKFcNITKVQHDDIDKVISMSLLRITR----EGQEPVFVKHVHWHNWPDHGVPESY--MSPLHLLNIFRS-----------------HQKPILIHCSA
..|.|  .| .. . .|...   || .      |. |. .|.|.|...|||||||..   .| |.||.  |.                 ...|.|.||||
tygdf.tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GVGRTGTLALILIALQTLrSvDFSGIRPLFTRLREERFK-AIQTEMQYLFVHRCVLEYLVQKK
||||||||... . |. |   .   .   .. ||. |   |.|...|| |.....||.| ..|
GvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
0042113 (Phosphotyrosine protein) phosphatases II 290-522 3.6e-62 205.3 In-house 4-243 (245) alignment 
Range on Protein: 290-522
Range on HMM: 4-243/245.0
QVFVANPTRNRYTNIPCCDATRVKIDDDP----DFYIHANIVSSAK-YRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSklG
. ...|...|||..|...| ||||. .|.    . ||.|. |.  . ....|..|.||..|.| ||||. . |...||||.|  |||..|.| |.|.  |
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

QAMRIGKFCNITKVQHDdiDKVISMSLLRITR-EGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRS-----HQKPILIHCSAGVGRTGTLALILIA
. ...|.|.  ..  .   .. . .  |..|.    |. .| |.|...|||||||..  . | .|.. |.      ..|.|.|||||||||||.......
esltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
|. |..     .   . .||. | .|.||. || |.....||.|
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 254-526 6.5e-61 200.6 In-house 7-293 (305) alignment 
Range on Protein: 254-526
Range on HMM: 7-293/305.0
KKEIINAWIRHVLSIGIEGLKKEYQDSPNGGSIRSAQV-FVA------NPTRNRYTNIPCCDATRVKIDDD-PDFYIHANIVSSA--KYRRIICAQAPLK
 . |.. ...  | .|.. |..|...  .      .|| | |      . |.|||...|| | . ||.|.  |  ||||| |       .|.|||| || 
thpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpld

GTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKFCNITKV---QHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPES
 ||.||| |..   || |||||  .|||| | |.|.|   |. . .   . . .|   .  . |  | ..||..|  |.. . |.|..| .||| |||  
qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppc

YMSPLHLLNIFRSHQKPILIHCSAGVGRTGTLALILIALQTLRS-VDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKK
 .. | ||   |  . ||..|||||.|||||.  |   |. .    .   .  |   ||..|  .||...||||.|| .|.|...| 
kltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
0037934 (Phosphotyrosine protein) phosphatases II 291-521 1.8e-59 196.6 In-house 6-241 (243) alignment 
Range on Protein: 291-521
Range on HMM: 6-241/243.0
VFVANPTRNRYTNIPCCDATRVKIDDdpDFYIHANIVSSAKyrRIICAQAPLKGTIEE----FWRMILSSGVEYIVMLCEIIELGKEKSANYFPsklGQA
 ...| ..|||..|...| .|||...  . ||.|| .   .  |.|. |.||..|.|.    ||||. . |...||||.| .|||.|| | |.|   |. 
llpenlsknrysdilpydhsrvkleg..sdyinanliyvtp..rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev

mRIGKFCNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFR------------SHQKPILIHCSAGVGRTGTLAL
 ..|.|.  .. ..   | .. . ||. . ..... .| |.|...|||||||.|  . | .|.. |            ....|.|.||||||||||||..
.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

ILIALQTLrsvDfSGIRPLFTRLREERFK-AIQTEMQYLFVHRCVLEY
... |. |   .  ..   . .||| |.  |.||. || |.....||.
aylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 257-527 7.4e-58 190.5 In-house 13-288 (290) alignment 
Range on Protein: 257-527
Range on HMM: 13-288/290.0
IINAWIRHVLSIGIEGLKKEYQDS--PN-GGSIRSAQVFVANP--TRNRYTNIPCCDATRVKIDDD-PDFYIHANIVSSAKYRrIICAQAPLKGTIEEFW
 .. .  .| . ....| ||| .   |   .     ..| .|.  ..||| ...| | ||| ..|  .  |.||| |   |   .| .| .|| |. ..|
afekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkam.filtqGalkdtvidiw

RMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKFCnITKVQHDDIDKVISMSLLRIT--REGQEpVFVKHVHWHNWPDHGVPESYMSPLHLL
||.|  .| .||||||.|| || | ..|.| | |... .|..  ..  ..|| |. | . .| .    .|.|   .||..   |||. |. | .. | .|
rmvlqekvaaivmlceliedGkakceqyypekeGevltfGeit.vlcseeddkdaniikktlsvrdkdsGke.hklkhlkikswpdksvalstlallrtl

NIFRSHQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKY
 | |    |. .|||||.|||||.. | ..|| |       .  |   ||. | ...| ..||| . . .|.. .. ||
rilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 254-542 2.4e-55 182.4 In-house 2-297 (312) alignment 
Range on Protein: 254-542
Range on HMM: 2-297/312.0
KKEIINAWIRHVLSIGIEGLKKEYQDSPNGGSIRSAQVFVANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVS-SAKYRRIICAQAPLKGTIEEFWRM
. |.|. |   |.    . | |||.   |  |      |.     ||| || | |  |  .  | .||||||.|   .|  |..|.|.||. |.  ||..
raemikkwasavmmstpqqltkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwql

ILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQ-----AMRIGKFCNITKVQHDDIDKVISMSLLRITR-EGQEPvFVKHVHWHNWPDHGVPESYMSPLH
 || |   |..|| ..| | ||.|.|    .|           ..|   ..     ||.    |  . .  |||   ..|  |  |||||.|.|  . | 
alslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdtalr

LLNIFRSHQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQK-KYNVNRDDYTKFLKEYK
||   .  .||.. |||||||||||||||   . .||      ..  |  || .| .....  ||... |||||.|  |  |. | ...||| . | 
llsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfketya
subfamily_PTPRD_pd Subfamily PTPRD 273-542 4.7e-55 182.3 In-house 25-301 (564) alignment 
Range on Protein: 273-542
Range on HMM: 25-301/564.0
LKKEYQDSPNGGSIRSAQ-VFVANPTRNRYTNIPCCDATRVKIDD----DPDFYIHANIVSSA-KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCE
...||..  .| . .  .    ||  .||| ||   |..||..      .   || |. . .  | .  | .|.||. |||.||||.    .. |||| .
feeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltk

IIELGKEKSANYFPSKlGqAMRIGKFcNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSH----QKPILIHC
. | ||.| ..|.|.| |   ..|..  .| ... .. ...  ..   . . .|   |.. |. .|||||||||  | |.|..  |..    ..||..||
leEkgkvkchkYWPek.g.tetygel.tVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhC

SAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYTKFLKEYK
|||||||||   | . |. ... .   |.   ..||..|   .||| || |.|. .||.|   . .|. ..... |.. .
SaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa
subfamily_PTPRB_pd Subfamily PTPRB 290-526 9.3e-55 180.7 In-house 46-289 (293) alignment 
Range on Protein: 290-526
Range on HMM: 46-289/293.0
QVFVANPTRNRYTNIPCCDATRVKI----DDDPDFYIHANIVSSAKY-RRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLg
    .| ..||||||   |..|||.    |.. . || || ..  .  |  | .| || .|...||||.. . .. |||| ...| ||.|  .|.|..  
aelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.

QAMRIGKFcNITKVQHDDIDKVISMSlLRITReGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQ------KPILIHCSAGVGRTGTLALILIA
...  |.  ..| |.... .. .  . |.|.. ..|   |.. |.  ||||||||.  . |.... .|...      .||..|||||||||||.  .   
epvlyGdi.kvtlvaeeeledwvire.lkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrl

LQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKK
||.... |.  |  . ..|||||.  .||| ||.|.|.|||..| .|.
lqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 253-527 1.3e-54 180.0 In-house 4-292 (305) alignment 
Range on Protein: 253-527
Range on HMM: 4-292/305.0
KKKEIINAWIRHVLSIGIEGLKKEYQDSPNGGSIRSAQVFV--ANPTRNRYTNIPCCDATRVKIDDD-PDFYIHANIVSS-AKYRRIICAQAPLKGTIEE
..|  |  .....|  | .||..|..       .   . |    .  .||| .. | |  |||..   |  ||||| ||. .. .|.||.||||. |  .
qqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcad

FWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIG--------KFCNITKVQ-HDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPE
|| | |   ||.| |||...| | .| ..||.|| .. . .         ||   .... ..| . ... . | |   |..   |.| || .||| ||| 
fwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa

SYMSPLHLLNIFRSHQKPILIHCSAGVGRTGTLALIL-IALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKY
. .. | ||.  |. . || .|||||.||||.. ..  |  | |          .. ..||.| ..|||. ||||||. .|.|. .|| 
adlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl
subfamily_PTPN12_pd Subfamily PTPN12 294-529 6.8e-54 177.7 In-house 39-283 (290) alignment 
Range on Protein: 294-529
Range on HMM: 39-283/290.0
ANPTRNRYTNIPCCDATRVKIDD----DPDFYIHANIVSSA-KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMR
 | ..||| .|   | .||..      . . || ||..  . .  . | ||.||  |...||||| .  || .||.|...|||| | . |.|.. .....
envkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeele

IGKFCnITKVQHDDIDKVISMSLLRITREgQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQ----KPILIHCSAGVGRTGTLALILIALQTLRS
.|.|. .|. ... .|. . .  |..... .|   |.  |...|||||||.|  | |.|.. .|..|    .|...|||||||||||.  | .. . |..
fgefe.vtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellka

VDF---SGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLvQKKYNV
        .  | ..||..|  ..||. || .|...|.|.. ||. ..
ekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv.qkelei
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 271-525 1.1e-48 160.8 In-house 15-279 (281) alignment 
Range on Protein: 271-525
Range on HMM: 15-279/281.0
EGLKKEYQDSPNGGSI--RSAQVFVANPTRNRYTNIPCCDATRVKI----DDDPDFYIHANIVSS-AKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVM
.|...||..  . |     .|    .| ..|||.||   ||||||.    ..    || || |..  . .. | .|.|.  ....||.|...  |. |||
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivm

LCEIIELGKEKSANYFPSKLgQAMRIGKFcNITKVQHDDIDKVISMSlLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIF---R--SHQKPI
. . || || |   |.| .  .....|..  ...... .  . |.   ....||. |.. |..... .|||||||.. .  |.  .     .  ... |.
vtreieagklkChrYWPddn.selkygdv.tvkstaeeekatyierk.fkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkapl

LIHCSAGVGRTGTLALILIALQTL-RSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQK
.||||||||||||   .  ..... ..     .. . . ||.||   .|| .|| ||.. ||..| ..
vihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 269-522 3e-48 159.3 In-house 19-279 (288) alignment 
Range on Protein: 269-522
Range on HMM: 19-279/288.0
GIEGLKKEYQDSPNGGSIRSAQV--FVANPTRNRYTNIPCCDATRVKIDD----DPDFYIHANIVSSA-KYRRIICAQAPLKGTIEEFWRMILSSGVEYI
. .|...||.  .. .. .| ..     | ..||| ||   | .|||...    .   || |. . .  | .. |..|.||  |...||...    .. |
nrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktsti

VMLCEIIELGKEKSANYFPSKlGQAMRIGKFcNITKVQHDDIDKVISMSLLRItREGQEpVFVKHVHWHNWPDHGVPESYMSPLHLLNIFR----SHQKP
||| |..| ||.|  .|.|.. ..  . |.. ..| |.. . ....  .||   ....| . ... ..  ||||||||| .  |.||..      . ..|
vmltelveggktkCeeYWPda.dkpknyGsv.tvtlveskeledfvlrkllle.kkkte.leitqyqylaWpdhgvPeskapllellrqvkvanqadtgp

ILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
|..|||||||||||   .  ....... |.  .    ..||..|.  .||. || |.....|.  
iivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 261-545 1.2e-47 157.5 In-house 10-303 (318) alignment 
Range on Protein: 261-545
Range on HMM: 10-303/318.0
WIRHVLSIGIEGLKKEYQDS-PNGGSIRSAQ-VFVANPTRNRYTNIPCCDATRVKIDDDPD----FYIHANIVSS-AKYRRIICAQAPLKGTIEEFWRMI
 .|.. . |   |..||.   ..  .. | . .  .| ..|||.||   | ||||...  .     || || .    . .  | |||||  |||.||||.
hvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmv

LSSGVEYIVMLCEIIELGKEKSANYFPSKlgQAMRIGKFcNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRS
   .   |||| .. | ||.| ..|.|||  ... .||   ..  .. .... .  ..    .| .|   |.  |. .|||.||||| .| |.|.   ..
WeqnsavivmltqeeergkakvhryWPsk..gsrsygkl.vvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvsk

HQ-----KPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYTKFLKEYKVAE
 |     .||..||||||||||.   . | |. ..      .    ..|||.|   .||| || |..  .||.|   . .|. .| .. ..| . ..
aqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqd
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 269-523 2.6e-46 153.2 In-house 25-291 (298) alignment 
Range on Protein: 269-523
Range on HMM: 25-291/298.0
GIEGLKKEYQDSPNGGS-IRSAQVFVA----NPTRNRYTNIPCCDATRVKIDD----DPDFYIHANIVSSAKYR-RIICAQAPLKGTIEEFWRMILSSGV
.. |...|.|   .. | |....  ||    |  .|||..|   | .|| . .    .   || |  ....| |   | .||||. |.|.||||.    .
kltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedi

EYIVMLCEIIELGKEKSANYFPSKlgQAMRIGKFcNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRS-----
. |||| .. ||.| |  .|.|..  .. . |.. ...  ....  ..|.. |    .. ..   |...|. .|||.|||| . | |.||.  |      
gtiVmltnleeldktkyhkywPde..gketygei.tvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqa

HQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLV
 .||....|||||||.||   |   |. ..      ..    .||..| .|.||| || |..  |||.| 
gnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 264-551 1.2e-45 151.0 In-house 16-310 (319) alignment 
Range on Protein: 264-551
Range on HMM: 16-310/319.0
HVLSIGIEGLKKEYQDSPNGGSI--RSAQvFVANPTRNRYTNIPCCDATRVKIDDDPD----FYIHANIVSSAKYR-RIICAQAPLKGTIEEFWRMILSS
.. | |  .|.||...  ....   .||.    | ..|||.||  .| |||.. . ..     || |. . . . | . | .||||. |||.||||.   
alastgetllekefkllkeavndtfdsas.keenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWee

GVEYIVMLCEIIELGKEKSANYFPSKlgQAMRIGKFCNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLN-IFRSHQ
..  .|||... | .| |  .|.|..  . .. |..    . ..   | .|.   |..  .  |   ||| .. .||||.|||. .| |.||. | .|..
essivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksre

K----PILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYTKFLKEykVAEKISSGN
|    || .|||||||||||   . ..|. ..      .     |||  |   .|.. || |..  .||..   . ... .|  . ||.  .|||..   
ktqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq..laekvadtg
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 260-534 3e-45 149.7 In-house 11-295 (305) alignment 
Range on Protein: 260-534
Range on HMM: 11-295/305.0
AWIRHVLSIGIEGLKKEYQDSPNGGSIRSAQVFVANPTRNRYTNIPCCDATRVKIDDDPD----FYIHANIVSSAKYR-RIICAQAPLKGTIEEFWRMIL
|.|... ..  .||...|.  .. ..    .   || ..||...|   |  |...  ...     || |. | . | . . | ||.||| |...|||.|.
ayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliv

SSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKFCNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSH
   |. ||||....| ||.|   |.| . .. ...|.|  . | ..   | ..    . | .| .|   | . .  .|||||||..  | |.|..  . .
eekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkd

Q-----KPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDY
|     .|.|.||||||||||.   . |||. |.  .   .  .  .||..| |..||  || |.|  . |..   . ..  ...
qkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnl
subfamily_PTPN23_pd Subfamily PTPN23 275-522 4.9e-45 148.6 In-house 26-280 (288) alignment 
Range on Protein: 275-522
Range on HMM: 26-280/288.0
KEYQDSPNGGSIRSAQVFvanPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVS--SAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGK
.. .   .. ||  |...   ...||...|   | .|||...  | || |  |   |.    .|..||||..|. .||.|. .  .. |||| .  ||||
qkqdkearkrsiaiakly...seknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgk

EKSANYFPSKLGQAMRIGKfCNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRS--------HQKPILIHCSA
.| ..|.|.. |.... |.  ..|  .. . ....   |   |.. ..   |.|.....||..|||.|  . |..|.  .|         ..|...||||
pkvdrYwPedkgetvkfgd.lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsa

GVGRTGTLALILIALQTLRSV-DFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
||||||..||.  |.. |.       |  .. ||||.|   .|.. |. |.   |||. 
GvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPN13_pd Subfamily PTPN13 294-523 5.1e-45 148.9 In-house 36-270 (273) alignment 
Range on Protein: 294-523
Range on HMM: 36-270/273.0
ANPTRNRYTNIPCCDATRVKIDDDPDfYIHANIV----SSAKYRRIICaQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRI
.| ..||| |.  .|.||||..|.   || |. .       .|. |.| | ||  |...||.|.    .| |.|.    | || |   |.|.. .. . .
enkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiac.qGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkv

GKFCNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQK---PILIHCSAGVGRTGTLALILIALQTLRSVD
    ......  . |     .|  .  | .|   | |... .||||||| | .. |...   |. |.   ||..|||||.||.|||  | ..|. .    
snrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdk

FSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLV
   .. .  .||| |   .||. ||.||.. .|| | 
efdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN3_pd Subfamily PTPN3 293-520 2.1e-44 146.5 In-house 39-273 (280) alignment 
Range on Protein: 293-520
Range on HMM: 39-273/280.0
VANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVS-----SAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSkLGQAM
 .| ..||| .|   ||||||... .  || || |.     ..   | | .| ||. | ..||.|.    .. |||| ...| |. |  .|.|.  .. .
penlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedel

RIGKFcNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSH----QKPILIHCSAGVGRTGTLALILIALQTLR
. |.| ...  ..|   ...   |.   .| .|   . .. . .|||||||..  . |....  |.     ..|...|||||.|||| | |. .||. . 
eygef.svkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalie

SVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLE
. .   .  .  ..|. |   .||. || ||  ..|.
aaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 292-523 3.2e-44 145.9 In-house 17-265 (270) alignment 
Range on Protein: 292-523
Range on HMM: 17-265/270.0
FVANPTRNRYTNIPCCDATRVKID----DDPDFYIHANIVS--SAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQ
.. ... |||..|    ||||...    |.   || || |   . . .. |.|..||. |...|||||... |. |||. .. | |..| . |.|.. ..
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

AMRIgKFCNI-TKVQHDDIDKVISMSLLRITREGQEPVFVkHVHWHNWPDHGVPESY---MSPLHLLNIFRSH---------QKPILIHCSAGVGRTGTL
 ... .. .| . ....  ..   .  ||....|.|   | | ....|||||||..    .|. .||...|           ..|.|.||||||||||||
kvkl.edgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

ALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLV
 .. ||...| .     .  . ..||..| . .|.  || |... |.||  
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 294-524 7.2e-44 144.9 In-house 8-244 (250) alignment 
Range on Protein: 294-524
Range on HMM: 8-244/250.0
ANPTRNRYTNIPCCDATRVKIDDDP----DFYIHANIVSSAKYRR-IICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEkSANYFPSKlgQAMR
.|  .|||..|   | .|| .  .       || |  . . . |.  | .|.||. |||.||||.|   .. |||| .. | .|.   .|.| .  .| .
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..kaek

IGKFcNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIF-RSHQK----PILIHCSAGVGRTGTLALILIALQTLR
 |.   ..  ...    ...  |    .. .. . |...|. .||| |||| . . |.||.   .|.|.    |....|||||||.|.   |   |. |.
yGdv.tvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

SVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQ
      .. .  .||..| .|.... || ||.. .|..|. 
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 276-544 9.5e-44 144.5 In-house 24-299 (315) alignment 
Range on Protein: 276-544
Range on HMM: 24-299/315.0
EYQDSPNGGSI--RSAQvFVANPTRNRYTNIPCCDATRVKI---DDDPDF-YIHANIVSSAKY-RRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEII
|..| |.      |.|.    | ..||| ||   | .|||.   ||.||  || |  . | .  .  |..|.||| ....||||.| . |  |||. .  
efhdlpdPdiyrqrvar.etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkq

ELGKEKSANYFPSKLGQAMRIGKFcNITKVQHDDIDKVISMSLlrITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSH----QKPILIHCSA
|  | | ..|.| . ..... |.. ... .. .     .   |  .||...|   |   ....|||.||..   | |.|.   ..     . ..|.||||
egdkikcrqywPdrkadsvefGsi.kvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsa

GVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYTKFLKEYKVA
|||||| .  |   .. ..  .   .  . . ||..| . .||| .| |..  |||.|  ..  .    .| .|.. ...
GvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhts
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 272-526 2.7e-43 142.7 In-house 12-273 (281) alignment 
Range on Protein: 272-526
Range on HMM: 12-273/281.0
GLKKEYQDSPNGGSIRSAQVF--VANPTRNRYTNIPCCDATRVKIDD-----DPDFYIHANIVSSAKYR-RIICAQAPLKGTIEEFWRMILSSGVEYIVM
 .|.|. . |       . ||    |  .|||.|||| | .||..       .   ||||| . |   .   | .| | | |  .|||||       |||
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

LCEIIELGKEKSANYFPSKLGQAMRIGKFCniTKVQHDDIDKVISMSLLRITREGqEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQKPILIHCS
||...|  .|| |.||| .   .... |.    . .   ..| .  . | .. || |  .. |  |..|||  ||||    |..|   |..  | .||||
lcqfletnrekcaeyfprnahcclqfdkls..vsyedstvnkslvttrlnlsyeg.etrlithwlwkewpdwqvpessevmlkilrkirarstppvihcs

AGVGRTGTLALILIALQTLRS-VDFSGIRPLFTRLRE-ERFKAIQTEMQYLFVHRCVLEYLVQKK
|||||.|||  . ||||...| . .  |. . ..||   |  ..||  ||... . .|.. |  |
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk
subfamily_PTPN6_pd Subfamily PTPN6 293-526 2.1e-42 140.2 In-house 52-301 (306) alignment 
Range on Protein: 293-526
Range on HMM: 52-301/306.0
VANPTRNRYTNIPCCDATRVKID--DDPD-FYIHANIVS---SAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQA
. | ..||| ||   | |||..   . |.  || ||...     . .. | .|  |. |...||||..    . |||. . .| |||| | |.|..  . 
penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeeke

MrIGKFcNITKVQHDDIDKVISMSLlRI--TREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFR--------SHQKPILIHCSAGVGRTGTLALIL
.  ||  ..|.|. .. .. |  .| ..  .....|   | . |...|||||||..    |..|.  .        ... ||..|||||.|||||. .| 
e.yGki.svtnvseksladYilRel.svskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviD

IALQTLRSVDFS---GIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKK
| |.....  .     |. |   .|| |   .||| || ||.. . .|. .||
illkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
0051429 (Phosphotyrosine protein) phosphatases II 321-523 2.5e-42 140.7 In-house 6-226 (272) alignment 
Range on Protein: 321-523
Range on HMM: 6-226/272.0
YIHANIVSSA----KYRRIICAQAPLKGTIEEFWRMiLSSGVEYIVMLCEIIELGKEKSANYFP----------SKLGQAMRIGKFCNITKVQHDDIDKV
||.|. |.      | .|......||. |...|||.  . |. .||.|..  |.|..|   | |          .   . ...|... ..   .   | .
yiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyi

ISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYmsPLHLLNIFRShQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSG--------IRPLFTRLR
. . ||...   .|.  | | |...|||||||...   |.||..... ..|.|.|||||..||||....|. |. .   .           ...   .||
lrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelr

EERFKAIQTEMQYLFVHRCVLEYLV
. | .|.|||.||||.....||.| 
aqrpgavqteeqylflyeallellr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 291-525 2.6e-42 139.8 In-house 31-273 (285) alignment 
Range on Protein: 291-525
Range on HMM: 31-273/285.0
VFVANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVSS--AKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMR
 . |||  |||... | . ||| . .    ||||. .          | .| ||  |. .||.||    . |..||| ..| | || | |.| |||. ..
ayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

IGKF-CNITKVQHDDIDKVISMSLLRITRE--GQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNI---FRSHQKPILIHCSAGVGRTGTLalILIALQTL
.||.   .|... . |   |  .|  |  |    ||....||.   |||.  ||     . | .       ..||| .||||||||| |.  . |   |.
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatf..vgidyati

RSVDFSGIRP--LFTRLREERFKAIQTEMQYLFVHRCVLEYLVQK
| ..   |    .   .|  ||.|.|. ||.||..  ..||.. .
rimenpniemldivremramrfqavqshmqflflyvvlmeyfige
0041856 (Phosphotyrosine protein) phosphatases II 295-528 3e-42 139.6 In-house 1-177 (182) alignment 
Range on Protein: 295-528
Range on HMM: 1-177/182.0
NPTRNRYTNIPCCDATRvkidddPDFYIHANIVSSAKYR-RIICAQAPLKGTIEEFWRMILSSGVEYIVMLCeiielgkekSANYFPSKLgqamrigkfc
| ..|||..|...| .|      .  ||.||.. .. .  |.|..|.||..|...|.||. . |. .||.|.         . .|.|..|          
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell..........

nitkvqhddidkvismsllritregqePVFVKHVHWHNWPDHGVPEsYMSPLHLLNIFRSHQKPILIHCSAGVGRTGTLALILIALQTlrsvdFSGIRPL
                           .  . ......|||||||.   . |..... .....|.|.||||||||||||... . ..        ...  
...........................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleea

FTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYN
.  .|. |.....|. || |.....||.| .||..
vklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 272-524 7.6e-42 138.3 In-house 6-270 (274) alignment 
Range on Protein: 272-524
Range on HMM: 6-270/274.0
GLKKEYQDSPNGGSIRSAQVFVaNPTRNRYTNIPCCDATRVKI-----DDDPDFYIHANIVSSAKYR--RIICAQAPLKGTIEEFWRMILSSGVEYIVML
 |.||. . |   . .  .||  . |.|||..|   . .|| .     .|.   || || .   ...    . .| ||  |...|||||    |. ||||
dlekeflelPlnfdqeeldvfg.sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

CEIIELGKEKSANYFPSKLGQAMRiGKFC----NITKVQHDDIDKVISMSLLRITReGQEpvfVKHVHWHNWPDHGVPESYMSPLHLLNIFR-------S
 .. |  ..| |.||| . .  .  ...     ...|. . .  .| ...|.  .|  ..   |||  . .|||| .|..  . |.|..  .        
tklkeaneqkCavyfPdaedyeis.erygdveikvekiverndysvrklvlkyler.ers...vkhywytdWPdhksPddantlldlvleveesreeena

HQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQ
.  |...|||||.||||    |.||.. ||   .  .  . . || .|   .||. || ..|| . .|| .
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 297-541 1.1e-41 137.6 In-house 52-299 (301) alignment 
Range on Protein: 297-541
Range on HMM: 52-299/301.0
TRNRYTNIPCCDATRVKI-DDDPDFYIHANIVS-SAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKFCN
 ..|| ..||   | |.. .|     |||| .. | . .| |..|.||| | |.|| |.    || ||||.. .|  .|| ..|.|.| .. ..||.|  
dkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfki

ITKVQHDDIDKVISMSLLRITR--EGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQKPILIHCSAGVGRTGTL-ALILIALQTLRSVDFSgIR
 .| ..  ..| ||   |...   .  ..  | |  ...|.|.|||.|..   .|... .  .|||..|||||.||. .. .   .| . .       . 
kiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptie.lt

PLFTRLREERFKAIQTEMQYLFVHRCVLeYLVQKKYNVNRDDYTKFLKEY
  . .|||.|....||. |  ..    . | . |.|...   |.. |. .
ealkhlrehrwngvqtnsqlywmtlGtv.yrlikeygfdmkiyeeqlamf
subfamily_Ptp69D_pd Subfamily Ptp69D 272-533 9.2e-41 134.9 In-house 23-297 (307) alignment 
Range on Protein: 272-533
Range on HMM: 23-297/307.0
GLKKEYQDSPNGGSIRSAQVF--VANPTRNRYTNIPCCDATRVKID----DDPDFYIHANIVSSA-KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVML
||.|||.  ..  . .|..|     |  .||| .|   | ||||.     ..   || |. . .  . .. |.||.|. .||..|||||    |. ||||
glakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

CEIIELGKEKSANYFPSKlgQAMRIGKfCNITKVQHDDIDKVISMSLlRITR------EGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIF----RSH
 .. |  ..| | |.|    . .. |.  ... |...  .. |  .|  ...      | ..   |   |. .|.|  |||.  . |.|..      . .
snlteknrkkcakYWpie..devqygd.ilvklvseekhsdyiiRel.dvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln

QKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDD
. ||..||||||||.|..  . . || |.  |   |      ||..|   .|   || |..| .|.|    . ... ||
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvdd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 276-539 1.8e-40 133.5 In-house 23-293 (515) alignment 
Range on Protein: 276-539
Range on HMM: 23-293/515.0
EYQD--SPNGGSIRSAQVFVaNPTRNRYTNIPCCDATRVKI---DDDPDF-YIHANIVSSAKY-RRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEII
|..|   ||      ||  . | ..||| ||   | .|||.   .|.|.  |. |  . | .  .  |..|.|.| ....|||..|   |  |.|. .  
efhdlpgpniypqtvaqeei.nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklk

ELGKEKSANYFPSKLGQAMRIGKFcNITKVQHDDIDKVISMSlLRITREGQePVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQ----KPILIHCSA
|  | | ..|.| | |.... |.. ..  |  .     |    |..... .    |   |...|||.|||.   | | |.   .. .     |..|||||
egdkikcgkyWPdkpgdsvkfGsi.kvelvsleactggikrk.ltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsa

GVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYTKFLK
|||||| .  |   .   .  .   .  . | .|..| . .||. || |..  |||.|  ..  .    .|  |.
GvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 254-521 4.3e-40 132.2 In-house 10-289 (310) alignment 
Range on Protein: 254-521
Range on HMM: 10-289/310.0
KKEIINAWIRHVLSIGIEGLKKEYQD--SPNGGSIrSAQVFVANPTRNRYTNIPCCDATRVKIDDDP---DFYIHANIVSSAKYRR-IICAQAPLKGTIE
  . .. .|     .||||| |.|.   . .  |. . . .  .  .|||... | |..|||.  |    . ||||| | .   |  .||.| ||. || 
ylkalenfiiateklgieglvkqyrkldakqdssl.tyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtii

EFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSkLGQAMRIGK--FCNITKVQHD-DI-DKVISMSLLRITREGQ----EPVFVKHVHWHNWPDHGVPE
.|||||.    | |..|| . | |. |.  |.|| || .   |     |...  .. .| .  ...    .  . |    . . |. ..| |||| |||.
dfwrmifqeraesilllckvgeegrpkcvgywps.lgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd

S--YMSPLHLLNIFRshQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEY
   .  |  ||   |  . | ..|||||..|..... . .... |.  .   .  . | |. .|.. ||||.|||...|  . .
ekchtvpqrllaqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_PTPRK_pd Subfamily PTPRK 271-523 4.9e-39 129.0 In-house 22-278 (314) alignment 
Range on Protein: 271-523
Range on HMM: 22-278/314.0
EGLKKEYQDSPNGgsiRSAQVFVANPTRNRYTNIPCCDATRVK---IDDD-PDFYIHANIVSSA-KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLC
 |.|.||.  ..|     |     | ..||...|   | .||.   ||.|    || |... |  . .  | .| ||. |...|||...  .   |||| 
ygfkeeyeslfeg...wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlt

EIIELGKEKSANYFPSKLGQAMRIGKFCNITKVQHDDIDKVISmsLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQK----PILIH
|..| |. |  .|.| .  .   |   .  |... . . .. .  . ...|  .|   |..... .||||.|| |  . |.|.    ..|.    .|..|
elvevgrvkClkyWPedtevygdikvelvetellaelvvrifr..veklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvh

CSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLV
|||| |||||   | | |. ..  .   .      ||...   ..|| || |..  .||  .
CsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl
subfamily_PTPRG_pd Subfamily PTPRG 272-534 1.5e-38 127.4 In-house 20-299 (563) alignment 
Range on Protein: 272-534
Range on HMM: 20-299/563.0
GLKKEYQDSPNGGSIRSAQV----FVANPTRNRYTNIPCCDATRVKIDDDPD-----FYIHANIVSS-AKYRRIICAQAPLKGTIEEFWRMILSSGVEYI
|...|...  .    .. ..       |  .|||.||   | .|||. . |.      || || .    | .  | .| ||| |.. |||||    |. |
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaii

VMLCEIIELGKEKSANYFPSklGQAMRIGKFcNITKVQHDDID--KVISMSL--LRITREGQ--EPVFVKHVHWHNWPDHGVPESYMSPLHLLNIF-RSH
||. .. | |..|   |.|.   .....|.. ..| .... .    | ....  |.. .. |  .   |.. |. .||||||||. .  |   .   ...
vmitnlvergrrkcdvYWPk..desetygal.qvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

QK---PILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDY
..   ||..|||||||||||.  .   |. ... .   .  .  ..| .|   .||| ||.|.|  .|| .  |. ..  .. 
kaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv
0046846 (Phosphotyrosine protein) phosphatases II 312-522 4.4e-38 126.1 In-house 5-173 (176) alignment 
Range on Protein: 312-522
Range on HMM: 5-173/176.0
VKIDDDPDFYIHANIVSSAkyrRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMrigkfcnitkvqhddidkvismsl
. ..| .  ||.||.. ..   | |. |.|| .|...|..|... |....|.|.| .|||. | .||.|   .  .                        
llgldldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lritregqepvfvkHVHWHNWPDHGVPESyMSPLHLLNIFRSHQ---KPILIHCSAGVGRTGTLALILialqtLRSV-DFSGIRPLFTRLREERF-KAIQ
              ......|||||||..    |.||.. |...   .|.|.|||||.||||||....     |     .  .   . ..|| |. .|.|
..............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgavq

TEMQYLFVHRCVLEYL
|. || |.....|..|
tpeQyrflyefellll
subfamily_PTPRA_pd Subfamily PTPRA 293-539 9.7e-38 124.9 In-house 56-312 (330) alignment 
Range on Protein: 293-539
Range on HMM: 56-312/330.0
VANPTRNRYTNIPCCDATRVKIDD----DPDFYIHANIVSSAKY-RRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKlGqAM
  |  .||. ||   | .|| .      .   || |  .   |   . | || |.. |.|.|||||       |||| |. |  .|| |.|.|.. | ..
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde.G.lv

RigkFCNIT-KVQHDDIDKVISMSLLRIT-----REGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQ----KPILIHCSAGVGRTGTLALILI
    . ||. .|... . . ...  . ..     .. ...  |. .|.. ||| |||   .  |.||.  .. .     || .|||||||||||.  .  
t...yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivlda

ALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYTKFLK
 |. ...     .     |||  | . .||..|| |... .||| .    ...     |.|.
vlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlq
subfamily_PTPN1_pd Subfamily PTPN1 292-521 1.1e-37 124.4 In-house 29-270 (290) alignment 
Range on Protein: 292-521
Range on HMM: 29-270/290.0
FVANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVSSAK-YRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLG-QAMRI
. .| ..||| ..   | .|.|....   || |..|   .  |. | .| ||  |.. ||.|.       .||| ...| .. | |.|.|..   ... .
lpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekelll

G-KFCNITKVQHDDIDKVIsMSLLRIT-REGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFR------SHQKPILIHCSAGVGRTGTLALILIALQT
     ... ..... .. . ..||... .. ||   . | |.  ||| |||||  . |..|   |      |.. | .||||||.||.||..|.   |  
edtklkvkliseerksyyt.vrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvl

LRSV---DFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEY
.      .   |.  .  ||. |.  |||  |  | .  .|| 
iekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_PTPN14_pd Subfamily PTPN14 288-523 2e-37 123.8 In-house 42-297 (300) alignment 
Range on Protein: 288-523
Range on HMM: 42-297/300.0
SAQVFVANPTRNRYTNIPCCDATRVKID---DDPDFYIHANIVS---SAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPS
|.     |  .||. ..   . .||..    .. . || |  ..   ..| |  | ||.||. |...||.|.  .||. |||| |..| ||||| .|||.
staklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

K--LGQAMRIGKFCNITKVQHDdIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRS---H----------QKPILIHCSAGV
.    . .. |||  .|| ..|  |.|| ..|       .|   | |. . .||||||||   . |. |. ..|   .          . |.|.||||||
leskkktvefgkfkvttkfsed.sdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGv

GRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLV
|||| | |  . ..||   .   |.  ..|||| |   .||  || ||.. ...|| 
GrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 271-535 6e-37 122.2 In-house 24-292 (315) alignment 
Range on Protein: 271-535
Range on HMM: 24-292/315.0
EGLKKEYQDSPnGGSIRSAQV--FVANPTRNRYTNIPCCDATRVKI----DDDPDFYIHANIVSSAKY-RRIICAQAPLKGTIEEFWRMILSSGVEYIVM
.|.|..|.  | || ..  .|   . |  .||| ||   | .||..     |.   |. || .   .. || |.||.|.  ....|||..    .  |||
ngfkqdyesip.ggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivm

LCEIIELGKEKSANYFPSKlgqAMRIGKFCnITKVQHDDIDKvISMSLLRITrEGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQ----KPIL
| ...|  |.|. .|.| |    .  ||.  .|... .  .. ...  | ..  |..   |  .|.  ||| |||.. .. ..|    . |.     .|.
ltnlvegekrkaekywpdk...kviyGkit.vtrkseevnte.ytvrtlsvv.fgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaiv

IHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYT
.|||||||||||.  .   |. .   .   .  . |..|. | |..|.  || |..  .|| .|    .. .| | 
vhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlyl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 268-524 4.9e-36 119.1 In-house 17-285 (290) alignment 
Range on Protein: 268-524
Range on HMM: 17-285/290.0
IGIEGLKKEYQDSPNGGSIRSAQVFV--ANPTRNRYTNIPCCDATRVKID---DDP---DFYIHANIVSS-AKYRRIICAQAPLKGTIEEFWRMILSSGV
 | || .....   .| |  ...| .   | ..||..||   |  |. .    ...   . ||.|  .    . .. | .|.|.. |. .||..|    |
kgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekv

EYIVMLCEIIELGKEKSANYFPSKlGQAMrIGKFcNITKVQHDDIDKVISMSlLRITREG--QEPVFVKHVHWHNWPDHG-VPESYMSPLHLLNIFR---
  ||||..||| ||.|   |.|.. .... .|.| .|. ..   ... |    |... .   ...  |.. .  ||...| |..   . | . .. .   
tiivmltniieegkvkCqqYWpds.dtka.ygef.sikllneetlneyierk.levknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqr

-SHQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQ
 . ...|..|||..|||....  . ....  ..     .  .  ..|  . . .||. || .... ||.|| .
krgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 295-531 1.1e-35 118.2 In-house 51-293 (297) alignment 
Range on Protein: 295-531
Range on HMM: 51-293/297.0
NPTRNRYTNIPCCDATRVKI---DDDPD-FYIHANIVSSAKYrRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKeKSANYFPSKLGQAmrIG
|  ..||.||   |  |||.   .||||  |. |  | . |. |.|. | | | |...||.|.|   |  |||| .  |  | | |.|.. |  ..   |
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fG

KFCNITKVqHDDIDKVISMSlLRITREG-QEPVFVKHVHWHNWPDHGVPE--SYMSPLHLLN----IFRSHQK-PILIHCSAGVGRTGTLALILIALQTL
.   ...   ..    |  . | .|..  .   .||  .. .|||. |..  |  | |.|..     | .... |.|.||.||||||| |  |.  .   
dvsvvlls.vsereGfikre.levtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaea

RSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNR
.  .   |  | ..||.|| . .||. || ||.  |||.|. ...... 
krekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 293-527 1.9e-35 117.2 In-house 45-283 (287) alignment 
Range on Protein: 293-527
Range on HMM: 45-283/287.0
VANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVSSAKY-RRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKlgQAMRIGK
  |  .||.|.|   |  || . .  . || |  . . |  .. | |..|.  |. .||..|    |. |||||.  |  .|.  .|.|..  ... .|.
sqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpee..ksvvlGe

FcNITKVQHDDIDKVISMSL-LRITREGQEPVFVKHVHWHNWPDHG-VPESYMSPLHLLNIFRSHQK----PILIHCSAGVGRTGTLALILIALQTLRSV
. ||. ....  ...|   | .. . . ...  ||  .  ||...| |.|   . | . . .....|    .|..|||..|||....  . ....  .  
y.niellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckte

DFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKY
    .  .. . |  . ...||  || |.   |||||   . 
GviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
0036282 (Phosphotyrosine protein) phosphatases II 321-515 3.5e-35 116.6 In-house 4-163 (174) alignment 
Range on Protein: 321-515
Range on HMM: 4-163/174.0
YIHANIVSSA-KYRRIICAQAPLKgtieeFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSklgqamrigkfcnitkvqhddidkvismsllritREGQ
||.|. ..     .|.|. |.||.     ||.|. . |....|||.| .|||..|  ||.|.                                  .   
yinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lred

EPVFVKHVHWHNWPDHGVPESYMsPLHLLNIFRSH-----QKPILIHCSAGVGRTGTLALILIALQTLRsVDFSGIRPLFTRLREERFKAIQTEMQYLFV
.  .. .... .|||||||.. .  |..... ...     ..|.|.||||||||||||..... |. |.  ..  .  |. .||  | ...||. || |.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

H
.
y
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 275-541 2e-34 114.3 In-house 38-310 (319) alignment 
Range on Protein: 275-541
Range on HMM: 38-310/319.0
KEYQDSPNGGSIRSAQVFV---ANPTRNRYTNIPCCDATRVKIDD----DPDFYIHANIVSSAK-YRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCe
 |..  .. |   . | |     |  .||..||   | ..||..     .   || |  |.  .   . | || ||. |...|||||  . .  ||.|  
vefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.

iielgKEKSANYFPSKLGQAMRIGKfCNITKVQHDDIDKVISMSLLRITREgQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNI------FRSHQKPILI
     |.| ..|.| |  .    .|  ... |.  .   | .. | . ..| ..   ..  |.  |||.|||.. .  . |..          |...|..
.....kdkcsqywplkivikeerfk.vkvdsveetaeyvvrdielsedgke.kdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivv

HCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYTKFLKEY
||||||||||.   . . |. ..  .   .  .   ||..| . .|  .|| |..  .||  .  . .|   |.  .|.| 
hcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleel
subfamily_egg_pd Subfamily egg 295-541 2e-34 113.7 In-house 40-291 (307) alignment 
Range on Protein: 295-541
Range on HMM: 40-291/307.0
NPTRNRYTNIPCCDATRVKIDDDP----DFYIHANIVSSA-KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELgkEKSANYFPSKLGQAMRI
| .. |   ..| | .|||..       | .|||| |.    .   |.|||||| | ..||||.    |.|||||    |   |.   |.|    .....
nlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvt

--GKFcNITKVQH-DDIDKVISMSLLRITREGQEPVFVKHVHWhnwpDHGVPESYMSPLHLLNIFRSHQKPILIHCSAGVGRTGTLALILIALQTL-RS-
  | . .|. ..  .  | .  .. |..    .|  |..|  .    |        |||..|   |   ||.....  || ...||  | ||| .| |  
vpGsl.rienlkvdskadplfrvtklklvGgddeerflehwqg....dvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGp

VDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQ---KKYNVnRDDYTKFLKEY
.  | ..     || .|  .... ..||||.| || .. .      ..   || ..|.|.
itkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakel.dvdyerwleer
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 293-541 5.4e-34 113.0 In-house 23-274 (284) alignment 
Range on Protein: 293-541
Range on HMM: 23-274/284.0
VANPTRNRYTNIPCCDATRVKIDD----DPDFYIHANIVSSAK-YRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCeiielgKEKSANYFPSKLGQAM
  |  .||...|   | ..||..     .   || |  ..  .   . | .| ||. |...|||||  . .  ||.|       |.| ..|.| |  .  
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

RIGKfCNITKVQHDDIDKVISMSLLRITREgQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNI------FRSHQKPILIHCSAGVGRTGTLALILIALQT
  .|  ... |.  .   | .. | . ..| ..   ..  |.  |||.|||.. .  . |..          |...|..||||||||||.   . . |. 
erfk.vkvdsveeseeyvvrdielsedgke.kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldr

LRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYTKFLKEY
..  .   .  .   ||..| . .|  .|| |..  .||  .  . .|   |.  .|.| 
mkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
0043147 (Phosphotyrosine protein) phosphatases II 316-515 1.1e-33 111.8 In-house 2-154 (172) alignment 
Range on Protein: 316-515
Range on HMM: 2-154/172.0
DDPDFYIHANIVSSAKY-RRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIielgkeksanyfpsklgqamrigkfcnitkvqhddidkvismsllrI
|... ||.|. ..     .|.|. |.||  |...||||. . |. .||.|.|                                                
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................l

TREGQEPVFVKHVHWHNWPDHGVPeSYMSPLHLLNIFRS-----HQKPILIHCSAGVGRTGTLALILIALqtlRSVdfsGIRPLFTRLREERFKAIQTEM
.   ..  .. ......||||||| .    |..|.. ..      ..|.|.||||||||||||..... |   ...    .   .  .|| |..|.|.. 
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml...lgl...sleeavalvrekRpgavqnps

QYLFVH
|| |..
qyrfly
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 292-522 4.7e-33 109.2 In-house 35-277 (287) alignment 
Range on Protein: 292-522
Range on HMM: 35-277/287.0
FVANPTRNRYTNIPCCDATRVKIDDDPDF---YIHANIVSSA-KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKlGQAM
 .|.  .|||...   | ||| .  ....   || || |.|  .  . |.||.|.  |. .|||..|   .  ....   .| .. |  .|.| .  . |
elaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPm

RIGkFCNITKVQHDDIDKVISMSLLRI-TREGQEPVFVKHVHWHNWPDHGVPESYMS----PLHL---LNIFRSH--QKPILIHCSAGVGRTGTLALILI
|.|    .. ...|  .   ..  ||.   |..|   || ... .|||.... . ..     |     ... |.     |...|...|.||.|.|  .|.
rvG.GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlv

ALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
 .. | ..    .     |||| |   .|. .|. ..   .  | 
lvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_PTPN9_pd Subfamily PTPN9 258-455 6.8e-33 109.0 In-house 3-206 (297) alignment 
Range on Protein: 258-455
Range on HMM: 3-206/297.0
INAWIRHVLSIGIEGLKKEYQDS---PNGGSIRSAQvFVANPTRNRYTNIPCCDATRVKI----DDDPDFYIHANIVSSAKY-RRIICAQAPLKGTIEEF
|.. . .| . |..||.|||..    |  | .  ..   || ..||||.. | | |||..    .|.   ||.|| |   |  . .| .| ||| |...|
ieelvayvkekgkrGlskeyaeirnepveGtflask.lranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKFcNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLN
|||.  . |  |||   ..| |. | ..|.|.. ..... |.. ....|. .  ..    .|     . .|   | |     |||.|||.| .| |..|.
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdl.svsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

IFRSHQ
  |..|
kvrekq
0049260 (Phosphotyrosine protein) phosphatases II 331-515 9.6e-33 108.4 In-house 7-143 (152) alignment 
Range on Protein: 331-515
Range on HMM: 7-143/152.0
KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFpsklgqamrigkfcnitkvqhddidkvismsllritregqepvfvkHVHWH
. ...|..|.|.  |...||||. . |. .||||.|  ||||.| ..|.                                              .....
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................qylhl

NWPDHGVPESYMSPLHLLNIF----RSHQKPILIHCSAGVGRTGTLALILIALqtlrsvDFSGIRPLFTRLREERFKAIQTEMQYLFVH
.|||||||.. .  | || .     .. ..|.|.||||||||||||..... |          .   . ..|| | .|.... |. |..
pwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0049772 (Phosphotyrosine protein) phosphatases II 291-523 1.2e-32 109.3 In-house 42-281 (314) alignment 
Range on Protein: 291-523
Range on HMM: 42-281/314.0
VFVANPTRNRYTNIPCCDaTRVKIDD----DPDfYIHANIVSSAkyRRIICAQAPLKGTIEEF----------WRMIL--SSGVEYIVM-----------
 ...|...|||..|.. | .||...     . | ||.|. |..   .. |..|.||. |.. |          |||.|     | .|||           
dlflnrdknryldilpad.nrvilpglpvsgsd.yinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LCEIIELGkeksanyfpsKLGQAM-----RigkfcnitkvqhddidkvismsllritREGQEPVFV----KHVHWHNWPDHGVPeSYMSP
          |... ..|           .  |.     .                           .|  .| ..     .......||...| .    
rLdaAlgKtpllildgng..........neptaadlellk...........................eelydpelferlgikylripvpDgsap.lledf

LHLLNIFRS--HQKPILIHCSAGVGRTGTLALILIALQTLrSVDFSGIrplFTRLREERF-----KAIQTEMQYLFVHRCVLEYLV
...|.....   ..|.|.||.||.|||||.... . .  |  |..  .   . ..|. |.      .|.. .||.|.....|||| 
deflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll.gvsleea...ledvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 271-533 2.2e-32 107.5 In-house 23-299 (325) alignment 
Range on Protein: 271-533
Range on HMM: 23-299/325.0
EGLKKEYQDSPNG-GSIRSAQVFVANPTRNRYTNIPCCDATRVKI---DDDP-DFYIHANIVSSAKYRR-IICAQAPLKGTIEEFWRMILSSGVEyIVML
.|. .|..  |.  |  . . .  .|  .||. |.   | .|| .   .|||   || |. . . | .   . |||||  ||...||..|      .|..
dgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcs.vvvv

CEIIELGKEKSANYFPSKLGQAMRIGKFcNITKVQHDDI-DKVISMSLLRITrEGQEPVFVKHVHWHNWPDHGVP---ESYMSPLHLLNI----FRS---
 ....|||.. | |.| ..|.. . | . ..  .  ..| | |  .  .. . .. |   ||  ..  |.| ||.    . .| |.|..      ..   
lneldlgkdrcavywpkemgksktfGgl.evklrtieeisdyvhrvldvkqv.kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantk

HQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDD
   |||.||||||||||... .  ||. .       |     .||..| . ..|  || ... .. |...  . .|    
astpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvss
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 294-521 2.4e-32 107.0 In-house 32-265 (283) alignment 
Range on Protein: 294-521
Range on HMM: 32-265/283.0
ANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVS----SAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKlGqAMRI
 |.. ||. .|   |  ||... ..  || |  .       . .. | ||.||. |. .||.|.    .  |||| .. |  ..| . |.|.. | ..  
enkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr.G.sedy

GKFCnITkVQHDDIDKVISMSLLRITRE--GQEPVFVKHVHWHNWPDHGvPESYMSPLHLLNIFRSHQ-----KPILIHCSAGVGRTGTLALILIALQTL
|.|  .| ....   .  .. .| .  .   .. ... |    .| . | ... .  |  .|  .| |      ||..|||.|.|||...  .  ... .
Geft.vt.lrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkda

RSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEY
..     .    . .||.|  |.||  || .||  ||| 
ltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 265-526 4.4e-32 105.7 In-house 20-289 (302) alignment 
Range on Protein: 265-526
Range on HMM: 20-289/302.0
VLSIGIEGLKKEYQDSPNG-GSIRSAQVFVANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVSSA-KYRRIICAQAPLKGTI---EEFWRMILSSGVE
| |.    .|||..   .   .. . ..| .|. .|. ...|. |...||..  ||.|..|  |.     | || || | ...    ||||||. .  . 
vksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

YIVMLCEIIELGKeKSANYFPSKLGQAMRIGK-FCNITKVQHDDIDKvISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLH-LLNIFR---SH
 .|.|    || |    ..|| | |.    || | |. ||.. . .|    ..  .  .  . |...  . .||... ||..| .  .   ..|    . 
svvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkika

QKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKK
.....|    |.|| |..    .|...| . .   |  . . .|..| .|...  || ......| |. .| 
dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 304-535 3.4e-31 103.4 In-house 27-272 (290) alignment 
Range on Protein: 304-535
Range on HMM: 27-272/290.0
IPCCDATRVKIDDD----PDFYIHANIVSSAKYRRIICAQAPLKG-------TIEEFWRMILSSGVEYIVMLCEIIELGKEKS----ANYFPSKLGQAMR
.|   |||| . .      | ||||| |. ..  |.|  |.|..        |||.|| |.    |. .|||||  |  ...|    |.|.| . |. ..
vpLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelk

IGKFCnITKvQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQKPILIHCSAGVGRTGTLALILIALQTLR-SVDF
.. .  .   ..   .. . .  | .. ...|.  |.|   ..| .  |.|.  . |.|..  . .. |...||  |. |  .|| | .. | .  . . 
fkglt.vkC.kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgs

SGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYT
  .. .   ||..| .||...... ||   .. .... . .. ...  
vkledvlkalrkqralaitsalelafvdagivllaievldqfaeeete
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 339-526 3.9e-30 99.4 In-house 97-292 (302) alignment 
Range on Protein: 339-526
Range on HMM: 97-292/302.0
QAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKFCNITKVQHDDIDKV-----ISMSLLRIT---REGQEPVFVKHVHWH
  | | |.| .| .|    |  .| ||...| ...| |.|.  |.|. .. |...  |.  ..|...      . .  . |.   .. . .  |. ... 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

NWPDHGVPESYMSPLHLLNIFRSHQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKK
 ||||| |.   . |..|.   |..| .|.||||||||||||  |   .|     . . .  . . .|. |. |.|.| | ...  ||   |..|.
awpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmeka
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 295-538 2e-29 97.3 In-house 48-295 (439) alignment 
Range on Protein: 295-538
Range on HMM: 48-295/439.0
NPTRNRYTNIPCCDATRVKIDDDPD----FYIHANIVSSAKY-RRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKeksanYFPSKlGQAMrI
. |.||| ..   | ||| ... |      || || .      .  | .|.| | | ..|||...   .  ||||....|  |     |.||. ....  
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd.aevc.y

GKFCNITKVQHDDIDKVI-SMSLLRITREGQEPVFVKHVHWHNWPDHGVPE--SYMSPL-HLLNIFR--SHQKPILIHCSAGVGRTGTLALILIALQTLR
|  .  .  . .  . ||  . ..     ..    | ..|.  |||. ||   |... . . .|         |...|||||||||||.  . |||. |.
gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk

SVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYTKFL
. .   |. . . ||..| . .|.  ||.|.. .||| .|  .  |  |.. | .
lenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkef
0051082 (Phosphotyrosine protein) phosphatases II 321-519 1.1e-28 95.2 In-house 5-150 (151) alignment 
Range on Protein: 321-519
Range on HMM: 5-150/151.0
YIHANIVSSAkyrrIICAQAPlkgtIEEFWRMILSSGVEYIVMLCEIIELGkeKSANYFPSKLgqamrigkfcnitkvqhddidkvismsllritregqe
||... | .     ... ..|     ..|.... . |. .||.|..  | |  . ..|.|.                                       
yinfsyvtgg....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.....................................

pVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSH-QKPILIHCSAGVGRTGTLALILIALQTlrsvdfSGIRPLFTRLREERFKAIQTEMQYLFVHRCVL
 . |.|.....|||.|.|.|. . |..|...... ..|.|.|||||.||||||..... |.         .   .  .|. |. ..|...|.||.....|
.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfall
PTPc_DSPc_SM00012 424-520 1.3e-28 94.6 In-house 2-105 (105) alignment 
Range on Protein: 424-520
Range on HMM: 2-105/105.0
VKHVHWHNWPDHGVPESYMSPLHLLNIFRSHQK------PILIHCSAGVGRTGTLALILIALQTLRSV-DFSGIRPLFTRLREERFKAIQTEMQYLFVHR
|||.|...||||||||.  | |.||. ......      |...|||||||||||.... |.|| |..  ..  |  .. .||..| ...|||.||||..|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CVLE
..||
alle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 287-539 1.8e-28 94.0 In-house 38-253 (392) alignment 
Range on Protein: 287-539
Range on HMM: 38-253/392.0
RSAQVfVANPTRNRYTNIPCCDATRVKI---DDDPD-FYIHANIVSSAKY-RRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGkeksanyfps
..||    |  .||| ||   |..|||.   || ||  |. |  . | .  .  |..|.|   ....||||..   |  |.|. .. |            
tvaqk.einlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

klgqamrigkfcnitkvqhddidkvismsllritrEGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLN----IFRSHQKPILIHCSAGVGRTGTLALILI
                                    |..   |   |. .|||..||.   | |....     | .. .|..||||||||||| .  |  
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisids

ALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRDDYTKFLK
 .   . . .  .  . | .|..|   .||. || |.. .||| |. ..  .    .| .|.
vvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlq
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 295-520 2.7e-28 93.8 In-house 3-237 (237) alignment 
Range on Protein: 295-520
Range on HMM: 3-237/237.0
NPTRNRYTNIPCCDATRVKIDDD--PDFYIHANIVSS--AKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKlGQAMRIG
|  .||| || . | .|| .        || |. . .     .. |.|| ||. . ..||.|.       ||||  .||  ..|  .|.||   |    |
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaayg

KFCNITKVQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLL-NIF-RSH----QKPILIHCSAGVGRTGTLALILIALQTLRS
..    | . .  |  .   ||    . .|  ...  ..  |||.|||.   . | .  ||  ||.      | .||||||||||| . .|   |.  . 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

VDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLE
     |      . |.|   |||. ||.|.|. .||
kkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPRN_pd Subfamily PTPRN 275-520 1.4e-27 91.2 In-house 39-290 (297) alignment 
Range on Protein: 275-520
Range on HMM: 39-290/297.0
KEYQDSPNGGSIRSAQVFVanpTRNRYTNIPCCDATRVKIDD----DPDFYIHANIVSSAKYRR--IICAQAPLKGTIEEFWRMILSSGVEYIVMLCEII
..|.  |.  .. .|. .|   ..||....   | .|||...    . ..|| | ..     |.   | .|.||  |. .||.|.  .||  ||.|... 
cayeaepstkevakaeknv...kknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrle

ELGKEKSANYFPSKLGQAMRIGKFCNITkvQHDDIDKVISMSLLRITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHL----LNIFRSHQKPILIHCSA
| | .. ..|.| .  .   | .   ..  .|   |  .  |.     . .|   |   |.  ||..||| |  | |..       .|    ||..|||.
eegvkqckrywpdeGsevyhiyevhlvs..ehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsd

GVGRTGTLALILIALQ-TLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLE
|.||||.  || . |.  |. |    |      ||..| . ..|. |. |.  .| |
GaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0044763 (Phosphotyrosine protein) phosphatases II 314-525 7.5e-27 89.5 In-house 9-174 (178) alignment 
Range on Protein: 314-525
Range on HMM: 9-174/178.0
IDDDPD----FYIHANIVSSAkyrRIICAQAPlkgtiEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGqamrigkfcnitkvqhddidkvism
..  ..    .||.|. .       ..... |     .......   |. .||.|.| .|||..|.  |.|.. |                         
lsnleglersdyinaseilpg...lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.........................

sllritregqepvfvKHVHWHNWPDHGVPESYMSPLHLLNIFR----SHQKPILIHCSAGVGRTGTLALI-LIALQtlrsvDFsGIRPLFTRLREERFkA
                .... ..||||||...   | .... .    ....|.|.||||||||.|||... |.  .     ..  .   . ..|| |. .
...............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl.sleeaielvrerRp.i

IQTEMQYLFVHRCVLEYLVQK
.... |. ..... |..| ..
vpnpgqlrqLyefelrllkes
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 295-520 1.6e-26 87.9 In-house 7-238 (239) alignment 
Range on Protein: 295-520
Range on HMM: 7-238/239.0
NPTRNRYTNIPCCDATRV---KIDDDPD-FYIHANIVSS--AKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMR
| ..|||.||   | .||   |. .||   || |. .       .  |..|  .. .  .||||.       ||||  .||  |.|  .|.|    .   
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn

IGKFCNITKVQHDDIDKVISMSLLRITREgqepVFVKHVHWHNWPDHGVPESYMSPLHLLNIFR----SHQKPILIHCSAGVGRTGTLALILIALQTLRS
.      |.|  | | . . || .  | |     .| . |.  |||.|||.   . | |            .| .|||||||||||.. .|   |.  . 
lrvtlrktevfadyiirtfvmsqvgqtee....ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

VDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLE
     |      .||.| . .||  ||.|.| .|||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 295-520 2e-26 87.6 In-house 8-239 (239) alignment 
Range on Protein: 295-520
Range on HMM: 8-239/239.0
NPTRNRYTNIPCCDATRV---KIDDDPD-FYIHANIVSS--AKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMR
| ..|||.||   | .||   |. .||   || |. .       .  |..|  .. .  .||||.       ||||  .||  |.|  .|.|    .   
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn

IGKFCNITKVQHDDIDKVISMSLLRITREgqepVFVKHVHWHNWPDHGVPESYMSPLHLLNIFR----SHQKPILIHCSAGVGRTGTLALILIALQTLRS
.      |.|  | | . . || .  | |     .| . |.  |||.|||.   . | |            .| .|||||||||||.. .|   |.  . 
lrvtlrktevfadyiirtfvmsqvgqtee....ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

VDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLE
     |      .||.| . .||  ||.|.| .|||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 297-439 3.8e-26 86.6 In-house 35-181 (297) alignment 
Range on Protein: 297-439
Range on HMM: 35-181/297.0
TRNRYTNIPCCDATRVKIDDDP--DFYIHANIVSSA---KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGK
 .|||..|   | ||||.   .    || |. |      .  . |.|| ||. |...||...   .|  |||.... | |..| | |.||  .. .. |.
rknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagd

FC-NITKVQHDDIDKVISMSLLRITRegQEPVFVKHVHWHNWPDHGVPE
.  .      |. |.||   |  | |  .|   |.|| . .||||||| 
vvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvps
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 294-525 9.2e-26 85.4 In-house 32-259 (267) alignment 
Range on Protein: 294-525
Range on HMM: 32-259/267.0
ANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIVSSAKY-RRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIielGKEKSANYFPSKLGQAMRIGKF
 |  |||. .    | ||| . .  . || |  | . |  .  |  | ||| || .|. .|   .|  ||.|  .   ....   ..| |.||| .   .
knqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdl

CNITKVQHDDIDKVISMSLLRITREGQEPVFVkhVHWHNWPDHGVPESYMSPLHLL---NIFRSHQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSG
     ..... |  |    |..  |    | .   ....|      . |. ||  .   | .   ..|....||.||||.||.  |   |. ..  . | 
tvehslekeendyqiitlelkfknesahnvtl..yyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsd

IRPLFTRLREERFKAIQTEMQYLFVHRCVLEYlvqK
|  .. ..|. |   ..|  .|...|. . ||    
ifdflrkirsqriglvdtkeryiyihellaey...a
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 345-547 1.5e-25 84.8 In-house 40-244 (255) alignment 
Range on Protein: 345-547
Range on HMM: 40-244/255.0
TIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKfcnITKVQHDDIDKVIS--MSLLRITREGQEPVFVKHVHWHNWPDHGVPESYM
|...|...|  .. | .||||.  | |.||  .||| .. . ... .   .. .  . . .|.   . ..    | ..   ||| ... |...  ||   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad...vnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

SPLHLLNIFRSHqKPILIHCSAGVGRTGTLALILIALQ-TLRSVDFSG-----IRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKkyNVNRDDYTK
  |..| . |   |....|||.|.||. ...|. .. |  .||.| .       . | . ||..| .||.| .|  |    ||...  |  .   ..|..
eilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpk..geleakyqe

FLKEYKVAEKI
  | |  | ..
irksylharqm
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 294-526 1.9e-25 84.2 In-house 39-297 (301) alignment 
Range on Protein: 294-526
Range on HMM: 39-297/301.0
ANPTRNRYTNIPCCDATRVKIDDDPD------FYIHANIVSSA-KYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQA
.| . ||. ||   |  |. .   |.       || |. ...  . .. | ||.|.| |. .|||.|.   .  |||...  |  |.|. .|.|.   . 
enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaes

MRIGKF-CNITKVQ--HD------------DIDKVISMSLLRITREGqEPVFVKHVHWHNWPDHGVPESYMSPLHLLN--IFRSH---QKPILIHCSAGV
 . |.| . ... |   |              ..   .. ......  ..  |  ..  .||..||   .   |. ..  | | .     |...|||..|
eefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtV

GRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKK
.|.|.   . |.|   ..     .  .  ..|  . .|..|  || ...  . .||  ..
srsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
subfamily_hpo-7_pd Subfamily hpo-7 342-544 4.3e-25 83.1 In-house 43-250 (263) alignment 
Range on Protein: 342-544
Range on HMM: 43-250/263.0
LKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKF-CNITKVQHDDIDKviSMSLLRITREGQEPVFVKHVHWHNWPDHGVPES
|  ||..|...|  .. | .||||.  | |.||  .||| .. . ... .     ||||.| . |  .  || .  | ..   |||  .  |...  || 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllk..tlellstlgeKkkthtvkhysykgWiekndpel

YMSPLHLLNIFRSHqKPILIHCSAGVGRTGTLALILIALQ-TLRSVDFSG-----IRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRD-D
  . |..|.. |   |.. .|||.|.||.   ... .. |  .||.| .       . | . ||..| .||.| ||  |    ||.....   . . .  
areilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgeleak

YTKFLKEYKVA
| .  | |  |
yqeirksylha
subfamily_ptpA1_pd Subfamily ptpA1 289-482 4.1e-24 80.1 In-house 41-256 (418) alignment 
Range on Protein: 289-482
Range on HMM: 41-256/418.0
AQVFVANPTRNRYTNIPCCDATRVKI----DDDPDFYIHANIVSSAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLG
      | ..||||||   . |||..    | .   || || .  |  ...||.| ||  || .||||.    .  ||||    |  . |   |.| ..|
egdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

QA-MRI--------GKF-CNITKVQHDDiDKVISMSLLRITREGQEPvFVKHVHWHNWPDHGVPESYMSPLHLLN--------IFRSH--QKPILIHCSA
   . |        | .  .. .| .|  .. |    .|.| ||.    . . ..  |||| .|.      .||         |  |   . ||..||||
geqfsiygngnevfgtysvelveviqdp.ereiitrnirltfegetr.ditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsa

GVGRTGTLALILIALQTL
|||||||..  .| .. |
gvgrtgtfctavimmkkl
0048076 (Phosphotyrosine protein) phosphatases II 392-521 2.2e-22 74.7 In-house 16-142 (145) alignment 
Range on Protein: 392-521
Range on HMM: 16-142/145.0
F---CNITKVQHDDIDKVISMsllrITREGQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSH---QKPILIHCSAGVGRTGTLALILIALQtlRSV
.   ...   .. .|  |...     . .  .  .. .... .|||||||...   |..|.. ...    .|.|.||||||||||||... . |.  ..|
lptaldlellkdlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll..lgv

DfsgIRPLFTRLREERFKAIQTEMQYLFVHRCVLEY
.   .   . ..|. |..|.... |. |.....||.
s...leealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 393-516 3.9e-21 70.7 In-house 20-139 (144) alignment 
Range on Protein: 393-516
Range on HMM: 20-139/144.0
CNITKVQHDDIDKVISMSLlriTREGQEP-VFVKHVHWHNWPDHGVPESYMSPLHLLNIFRSH---QKPILIHCSAGVGRTGTLALILIALqtLRSVDfs
...   .. .|. ||...    ..| ... ... .... .|||||||...   |..|......    .|.|.||||||||||||... . .  .. ..  
ldlellkklgittvinlte...eyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk..klgls..

gIRPLFTRLREERFKAIQTEMQYLFVHR
 .   . ..|. |. |.... |. |...
.leealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 289-525 8.5e-21 68.8 In-house 41-282 (303) alignment 
Range on Protein: 289-525
Range on HMM: 41-282/303.0
AQVFVANPTRNRYTNIPCCDATRVKIDDDpdFYIHANIVSSAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMR
 . || |  .||.... | | ..||. |    ||||. .     .. | .| ||  |  .||.||.   |  ...|    |  |      || .      
knqfvknmdknrfvdvicldhskvklsds..syihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

IGKFCNITKVQHDDIDKVISMSLLRITrEGQEPVFVKHVHWHNWPDHGVPES----YMSPLH-LLNIFR--SHQKPILIHCSAGVGRTGTLALILIALQT
  ..  . . .. .. .  .. .| .. .|.   |..  |...||   .|      ..  .  |  ..|  |. .| .    .|.||.||.||.  |  .
eersirvgefkrvelgdgwvlkvlsvs.ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

LRSVDFS-GIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQK
| | . |  .   .  .|. |..|.|   |. .|.  . |.....
lhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldn
subfamily_CG7180_pd Subfamily CG7180 297-525 7.1e-20 65.8 In-house 44-293 (296) alignment 
Range on Protein: 297-525
Range on HMM: 44-293/296.0
TRNRYTNIPCCDATRVKID----DDPDFYIHANIVSS-AKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKeKSANYFPSKLgqAMRIGK
 .||. ..   | .|| ..    .. . || |  | |  | .  |  .|| | |..||||..   ... .|.|..  .  | .  .|.| |     . |.
eknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqyge

FCnITKVQHDDIDKVISmSLLRI-----------TREGQEPVFVKHVHWHNWPD-HGVPESYMSPLHLLN---IFRSHQ------KPILIHCSAGVGRTG
.  .  |...   .. .   ...           . .  |   ||....  |.  . || |  . ..|..   ..| .       .|.....| |..|.|
if.veiveekqyanlki.rtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

TLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQK
    | ..|. ..  .   .     .||..| . ...  .| ..   .||... .
vylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_CG42327_pd Subfamily CG42327 275-441 1.9e-17 57.9 In-house 9-180 (319) alignment 
Range on Protein: 275-441
Range on HMM: 9-180/319.0
KEYQDSPnGGSIRSAQVFVANPTRNRYTNI-PC--CDATRVKI-DDDPDFYIHANIVSSAK--YRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEII
.|..| |     |. .| |.   ..|. |. |     ..  .| ||| |.|..|. |   .      |.||..|. .  .|||..       || |... 
eefrdlP.qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

ELGKEKSANYFPSKLGQAMRiGKFCNI-TKVQHDDIDKVISMSLLRITR-EGQEPVFVKHvHWHNWPDHGVPESY
||| .. |.|.|.| .   .   . .|   ... ....   .| | . | ...|   . | .|..|.. .|| . 
elGikvcaeylPtketldnt.slyGdilvtlkgrevkdryaistlllkrvdkeesrelth.ywykwleaevPaee
subfamily_PTPN9_pd Subfamily PTPN9 452-525 4e-17 57.2 In-house 220-293 (297) alignment 
Range on Protein: 452-525
Range on HMM: 220-293/297.0
RSHQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQK
. .. ||..|||||.|||||.. . |.|. |..|.   ..    .||. |  .|||. || | . .|||| ...
hpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 418-541 5.8e-15 49.5 In-house 85-213 (440) alignment 
Range on Protein: 418-541
Range on HMM: 85-213/440.0
GQEPVFVKHVHWHNWPDHGVPESYMSPLHLLNIFR-S----HQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYL
| |   .|. |.. |||.|||.     |....    |     . |.|.|||||.|||| .  .   |.  .  |   |  .   .|..| . .||  || 
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FVHRCVLEYLVQKKYNVNRDDYTKFLKEY
||| .||| |.     .  || |. ... 
fvheavlegllcgdtliledditerveqi
subfamily_CG42327_pd Subfamily CG42327 452-521 8.1e-12 39.4 In-house 244-314 (319) alignment 
Range on Protein: 452-521
Range on HMM: 244-314/319.0
RSHQKPILIHCSAGVGRTGTLALILIALQTLRSV-DFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEY
|..| |. .||| ||||||..    ||...|        |  |   .|..| .|..|  || |... . ||
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 454-522 1.9e-11 38.3 In-house 227-295 (297) alignment 
Range on Protein: 454-522
Range on HMM: 227-295/297.0
HQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
 . ..|.||||||||.| . |  . |. ||      .. . . |||.| . .||  |. ...  ||. |
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_eak_pd Subfamily eak 316-439 2.7e-11 37.4 In-house 75-196 (332) alignment 
Range on Protein: 316-439
Range on HMM: 75-196/332.0
DDPDFYIHANIVSSAK-YRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKFcNITKVQHddIDKVISMSLLRI
 ... || | ..  ..  |. | . .. .  .  ||.|.|      ||.| | .||. |||  ||| |  . .. |.. .... ..  . . |    | .
lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil.dverkef..vkrniletrlle

TREGQEPVFVKHVHWHNWPDHGVPE
 . | |   |.| . . | .  .| 
lskGnethrvlhykvfGwtettlpk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 404-522 3.4e-11 37.5 In-house 197-344 (350) alignment 
Range on Protein: 404-522
Range on HMM: 197-344/350.0
DKVISMSLLRITREGQEPVFVKHVHWHNWPDHG---VPESYMSPLH----LLN-------IFRSHQKPILIHCSAGVGRTGTLALILIALQ--------T
|     ||  ||    .|  | .....||.| .    ||| .. |     |..       .  ....|||.||||||||||||  .   |.        |
dlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenlt

LRS--VD-----FSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
 .|  .|     .  |  .  .||. | . .|.  |..|.. ..| | 
kesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 297-381 8.2e-11 36.2 In-house 49-152 (350) alignment 
Range on Protein: 297-381
Range on HMM: 49-152/350.0
TRNRYTNIPCCDATRVKID------------DDPDFYIHANIVSSA--------KYrRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSA
..|||.||   . .|||.               .. || || .. .        .. . | .||||. |...|...||  .|. |..| . .||. ||  
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdf.kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

NYFPS
.|.. 
rYWqe
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 332-514 5.2e-09 30.5 In-house 4-196 (199) alignment 
Range on Protein: 332-514
Range on HMM: 4-196/199.0
YRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKFCNITKVQHDDIDKVISMSLLR-ITREGQEPVFVKHVHWH
 || |..| ||. |. .||.|.  .|  .|||. .     .   . |.|.    . . | ..  ||.     | .|.  .|   |        . |  . 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

NWPDHGVPESYMSPLHLLN-------IFRSHQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIR--PLFTRLREERFKAIQTEMQYLFV
 | ..  |.  .    ..          . .. |...||| | | || .  . | ...      | .    .  |||. |   | .  .| |.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 332-514 5.5e-09 30.5 In-house 3-195 (198) alignment 
Range on Protein: 332-514
Range on HMM: 3-195/198.0
YRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYFPSKLGQAMRIGKFCNITKVQHDDIDKVISMSLLR-ITREGQEPVFVKHVHWH
 || |..| ||. |. .||.|.  .|  .|||. .     .   . |.|.    . . | ..  ||.     | .|.  .|   |        . |  . 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

NWPDHGVPESYMSPLHLLN-------IFRSHQKPILIHCSAGVGRTGTLALILIALQTLRSVDFSGIR--PLFTRLREERFKAIQTEMQYLFV
 | ..  |.  .    ..          . .. |...||| | | || .  . | ...      | .    .  |||. |   | .  .| |.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
PTEN_1 400-474 9.3e-09 30.4 In-house 65-149 (196) alignment 
Range on Protein: 400-474
Range on HMM: 65-149/196.0
HDDIDKVISMSLLRIT--REGQEPV-FVKHVH--WHNWPDHGVPESYMSPLHLLNIFRS-----HQKPILIHCSAGVGRTGTLAL
.|.|  |...|. . .  |....   | ..|      ..|||.|   .    . ..  .     ... .|.|| ||.||.||.. 
edgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
0038934 (Phosphotyrosine protein) phosphatases II 426-475 3.3e-08 28.9 In-house 81-135 (194) alignment 
Range on Protein: 426-475
Range on HMM: 81-135/194.0
HVHWHNWPDHGVPESYMSP---LHLLNIF--RSHQKPILIHCSAGVGRTGTLALI
...   .||.|.. |.      |.|.. |  .. .. ...|| ||.||||||.  
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 399-523 4.4e-08 26.8 In-house 202-345 (349) alignment 
Range on Protein: 399-523
Range on HMM: 202-345/349.0
QHDDIDKVISMsllritrEGQEPVFVKHVHWHNWPDHGV---PESYMSPLHLLN----IF-------RSHQKPILIHCSAGVGRTGTLALILIALQ----
..|| |. | .       . ..|  .  .   ||.| ..   | |..  |.  |              ..  ..|.||||| ||||.|  . . |.    
pddddddaill.......avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsilep

--------TLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLV
        .|... .  |      ||  |.  .|   |. ... ..|.|. 
lqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 318-379 1.2e-07 25.4 In-house 89-153 (349) alignment 
Range on Protein: 318-379
Range on HMM: 89-153/349.0
PDFYIHANIVSSAKY---RRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELGKEKSANYF
.| || || .. ...   .. |. ||||  |...|...||  ||. .. | .  ||. ||   |.
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 459-522 1.4e-07 25.8 In-house 2-65 (69) alignment 
Range on Protein: 459-522
Range on HMM: 2-65/69.0
LIHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
..|||.| |||||.  |.. .  ..|  .  |      .|  |   .  |..|.|.|  . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 290-388 2e-07 22.9 In-house 40-139 (327) alignment 
Range on Protein: 290-388
Range on HMM: 40-139/327.0
QVFVANPTRNRYTNIPCCDATRVKIDDDPDFYIHANIV-SSAKYrriICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIELG---KEKSANYFPSKLGQ
  || |   |    ||  |  ||    | .|.    .    |.|   |  ||| | . .  ||.||   .  .| ||   ..      |   |||..| |
pefvknlpvnvrlpipirdnrrvlcgsdeeffpgqyvrmegaey...iivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleq

AMR
 | 
kme
subfamily_PTPDC1_pd Subfamily PTPDC1 428-517 4.8e-07 24.4 In-house 86-171 (182) alignment 
Range on Protein: 428-517
Range on HMM: 86-171/182.0
HWHNWPDHGVPeSYMSPLHLLNIFRS--HQKPILIHCSAGVGRTGTLalilIALQTLRSVDFSGIRPlFTRLREERFKAIQTEMQYLFVHRC
.   |.|.||. |  . | .  .  .  ... . .|| || |||| |    ||   . . .... .   . .|..| |.|||  |  .|.  
ynfgwkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvl....iacylvyakrltaeka.iklvrskrpksiqtreqvelvkef
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 460-522 5.5e-07 23.8 In-house 2-64 (69) alignment 
Range on Protein: 460-522
Range on HMM: 2-64/69.0
IHCSAGVGRTGTLALILIALQTLRSVDFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYL
.|||.| |||||.  |.. .  ..|  .  |      .|  |   .  | .|.|.|  . | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 290-385 3.5e-06 18.7 In-house 24-111 (275) alignment 
Range on Protein: 290-385
Range on HMM: 24-111/275.0
QVFVANPTRNRYTNIPCCDATRVKidDDPDFYIHANIVSsAKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEiielgKEKSANYFPSKLGQ
. |. |  .||.||. | |    .  .. .|..||| .  . |  .. .|||   |  .. ...    |. .| |        |..  ||  | |.
erfirngeknrftnvtcfdeildr..enqeffvhantfr.tpygnflisqapndstnadhlhllwiynvqtvvclvl.....peeaggyfvpkege
DSPc Dual specificity phosphatase, catalytic domain 450-475 8.7e-06 20.6 Pfam-A 68-93 (133) alignment 
Range on Protein: 450-475
Range on HMM: 68-93/133.0
IFRSHQKPILIHCSAGVGRTGTLALI
 ... .| .|.|| ||. |..||.. 
kaeqkgkkvlVHCqaGisRSatliia
DSPc Dual specificity phosphatase, catalytic domain 450-475 8.7e-06 20.6 In-house 68-93 (133) alignment 
Range on Protein: 450-475
Range on HMM: 68-93/133.0
IFRSHQKPILIHCSAGVGRTGTLALI
 ... .| .|.|| ||. |..||.. 
kaeqkgkkvlVHCqaGisRSatliia