Gene B0280.11 in Caenorhabditis elegans

Synonym: CELE_B0280.11, CELE_B0280.11

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP009_AA protein Get Run
CeleP009_AA_124-403 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 120-417 7.9e-120 393.8 In-house 2-301 (302) alignment 
Range on Protein: 120-417
Range on HMM: 2-301/302.0
NVEKGVKTWVEQLEKLVEIRK----LLEADFKPIDTMKVDLEKCQAFKKNIDYCQSENVELYDANRVKGGGEADFFYHATVTSIPSIStKSTILAQLPLS
.||.....|||. |..  ...     ....||.|||||||||||.|||||....|||.|...|.|.||...|.|....|. ...|... .|.|||||| .
kveeekekWveeeeakklvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPelt.rsiilaQlpkv

DSPHSLESFWLMVAAQKIQRLFILIGEDELDKaALSEYFP---EDFKEFKTIRVNNRKtVSKSDEQPnTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIP
||..|.|.|| ||...||....||.||.||.| .|||.||   .|.||.....||||| |.|..|.  |....||.|..|.....|.......|.. |.|
dsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvp

tVSYGRIAATAASVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLKHVKDPVLKS
 |.|.....|||.||...|..|....|||..||||||.||. ..|.||||.|..||||||..|||||||.|...| |||..||..|.|..|.|..|  |.
.vkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekk

KTEKV
|.|.|
kkeev
0040438 (Phosphotyrosine protein) phosphatases II 132-435 1.2e-43 145.0 In-house 12-310 (317) alignment 
Range on Protein: 132-435
Range on HMM: 12-310/317.0
LEKLVEirKLLEADFKPIDTMKVDLEKCQAFKKNIDYCQSENVELYDANRVK----GGGEADFFYHATVTSIPSISTKsTILAQLPLsdsPHSLESFWLM
| |.    ..|.  |. ....|.|  .. ....|.|.... .. .||..|||    || . . ...|   ..|....|  |..| ||   |...|.|| |
llksdf..talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPl...pntvedFwrm

VAAQKIQRLFILIGEDELDKAALSEYFP-EDFKEFKTIRVNNRKTVSksdEQPNTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIP--TVSYGRIAATAA
|  |... .  |  ..||..    .|.| ..........|......    ..  | .  ||..... |  . ..  . .|||...|  . .  ..   . 
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee...lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

SVFDsdiDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLKHVKDPVLKSKTEKVISQLEQF
....   |..  ... .. | ||.|.|..   ..| |. .  ....|.   .|.|||.|..|. ||.| | ..| | ....... ....  |.. .|. .
eale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllipl

ACEKMMEEDEE
|.... ....|
alddvklkeke
0050432 (Phosphotyrosine protein) phosphatases II 125-405 1.7e-41 138.0 In-house 28-303 (308) alignment 
Range on Protein: 125-405
Range on HMM: 28-303/308.0
VKTWVEQLEKlVEIRKLLEADFKPIDTMKVDLE-KCQAFKKNIDYCQSENVELYDANRVKGgGEADFFYHATVTSIPS-ISTKSTILAQLPLsdsPHSLE
|. ....|||    ..|||. |. .  .|..|| .. ....|.| ... ..  || .|||  .| . ...|   ...| ....  |..| ||   |...|
vldllkllek.aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPl...pntve

SFWLMVAAQKIQRLFILIGEDELDKAALSEYFPE----DFKEFKTIRVNNRKTVSksdEQPNTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIPTV--SY
.|| ||  |...    |  ..| ..    .|.|.    ...|.. ..|..... .   ..  |. ..|...... |  . ..  .  |||...|.   ..
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev...lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeil

GRIAATAASVFdsdidSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLKHV
 ..   . ...     .. .... .. | ||.| |..   ..| |...  ... |.   .|.|||....|. ||.| | ..| | ....
ldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0036941 (Phosphotyrosine protein) phosphatases II 143-405 1.7e-41 137.9 In-house 16-281 (297) alignment 
Range on Protein: 143-405
Range on HMM: 16-281/297.0
EADFKPIDTMKVDLE-KCQAFKKNIDYCQSENVELYDANRVKGGGEADFFYHATVTSIPSISTKsTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIG
.  |. .. .... . .......|.. ... ..  || .||| ..| . ...|   ...... |  |..| ||   |...|.|| ||  |... .  |  
lkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrk.fIatqgPl...pntvedFWrmvweqnvtvIvmlte

EDELDKAALSEYFP---EDFKEFKTIRVNNRKTVSKsDEQPNTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIPTvSYGRIAATAASVFD--SDIDSDAT
..||..    .|.|   ....... ..|..... .. ...  |. . ||..... |  . ..  .  ||| ..|. |.  . .    | .  . . |.  
lvelgrekcaqywpleegesltygdftvtllsvevv.llddytlrtlevtdtgngesrtvthfhytgwpdhgvpe.spaslldfielvrkvlkllpsggp

CAIVSNYGAGRAGSFLVGVQAIEKLQ---AGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLKHV
  . .. | ||.|.|..   ... |.       ..|.|.  ..|.|||.|..|| ||.| | . | . .|. 
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0043336 (Phosphotyrosine protein) phosphatases II 137-400 1.7e-40 134.6 In-house 17-276 (278) alignment 
Range on Protein: 137-400
Range on HMM: 17-276/278.0
EIRKLLEADFKPIDTMKVDLEKCQAFKKNIDYCQSENVELYDANRVK----GGGEADFFYHATVTSIPSISTKsTILAQLPLSDsphSLESFWLMVAAQK
  ..||...|. ....|.|  .. ....|.| ... .. .|| .|||    || . . ...|   . .....|  |..| ||..   ..| || ||  ..
nlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpe...tvedFwrmvwelg

IQRLFILIGEDELDKAALSEYFPEDFKEFKTIRVNNRKTVSksdEQPNTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIPTvSYGRIAATAASVFDSDID
.. .  | ...||..    .|.|..........|...|. .   ..  |.   ||... . |  . ..  .  |||...|. |   .      | .   |
vttivmLtelvelgrvkcaqYwpggsltygdftvtllkeeh...lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavrealed

SDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
|.   .. .. | ||.| |..   ..| |. .  ... |.   .|.|||.|..|. ||.| | ..| |
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 129-401 7.7e-38 126.3 In-house 16-304 (307) alignment 
Range on Protein: 129-401
Range on HMM: 16-304/307.0
VEQLEKLVEIRKLLEADFKPIDTMKVDLE---KCQAFKKNIDYCQSENVELYDANRVKGGG-----EADFFYHATVTSIPSI-------STKSTILAQLP
 ..|..| ... .|.. |. .  ..|.|    .. ....|.|.... .. .|| .|||        | . ...|.   .|..       ...  |..| |
llvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

LsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDfKEFKTIRVNNRKTVSKSDEQPNTQLYYEVVPK-DCAEAPFAMIEICDFWPDGKIP
|   |...|.|| |.  |... .  | ...||..    .|.|.. .|..|..    ...|.. ..  | ...|| ..  . |  . .. ..  |||...|
l...petvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvp

--TVSYGRIAATAASVFDSDiDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDA---PNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYG
  . .  ..   . ...... ...  ... .. | ||.|.|..   ... |...     ... |.   .|.|||.|.... ||.| | ..| . 
psfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 167-397 2.7e-37 123.8 Pfam-A 3-233 (235) alignment 
Range on Protein: 167-397
Range on HMM: 3-233/235.0
DYCQSENVELYDANRVKG---GGEADfFYHATVTSIPSiSTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFP---EDFKE
. ......  || .|||    .|. | ...| . .  . ..|. |..| ||   ....|.|| ||  .|.. ...|  ..| .. ....|.|   |....
kknRykdilpydktrvklkgsegpsd.YInAnyvkgyk.ekkkfIatQgPl...kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FKTIRVNNRktVSKSDEQPNTQLYYEVVPKDCAEA-PFA-MIEICDFWPDGKIPtVSYGRIAATAASVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQAI
...|.|...  ....... ...|.   . |...|  ..  .   .  ||| ..|  |.  .  .  .|  |  .... . ...  |.||.|.|..   ..
ygdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp.espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

EKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIA
|.|.|.. .....|  ..|.||| ....| ||.| | . 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 167-397 2.7e-37 123.8 In-house 3-233 (235) alignment 
Range on Protein: 167-397
Range on HMM: 3-233/235.0
DYCQSENVELYDANRVKG---GGEADfFYHATVTSIPSiSTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFP---EDFKE
. ......  || .|||    .|. | ...| . .  . ..|. |..| ||   ....|.|| ||  .|.. ...|  ..| .. ....|.|   |....
kknRykdilpydktrvklkgsegpsd.YInAnyvkgyk.ekkkfIatQgPl...kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FKTIRVNNRktVSKSDEQPNTQLYYEVVPKDCAEA-PFA-MIEICDFWPDGKIPtVSYGRIAATAASVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQAI
...|.|...  ....... ...|.   . |...|  ..  .   .  ||| ..|  |.  .  .  .|  |  .... . ...  |.||.|.|..   ..
ygdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp.espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

EKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIA
|.|.|.. .....|  ..|.||| ....| ||.| | . 
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0039614 (Phosphotyrosine protein) phosphatases II 140-404 4.9e-37 123.4 In-house 32-292 (297) alignment 
Range on Protein: 140-404
Range on HMM: 32-292/297.0
KLLEADFKPIDTMKVDlEKCQAFKKNIDYCQSENVELYDANRVKGGGEADF-----FYHATVTSIPSISTKSTILAQLPlsdSPHSLESFWLMVAAQKIQ
 ||...|. .  .|.|  .. ....|.| ... ..  || .|||  .| ..     ...|   . ... |.  |..| |   .|...|.|| ||  |...
tllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP...lpetvedFwrmvweqgvt

RLFILIGEDELDKaALSEYFPEDFKEFKTIRVNNRKTVSksdEQPNTQLYYEVVPKDCAeaPFAMIEICDFWPDGKIP--TVSYGRIAATAASVFDSDiD
 .  |  ..||..    .|.||.  ......|...|.     ..  |. . ||.....    . .   .  |||...|  . .  ..   . ... .. .
vivmLtklvelgr.kcaqywpeeggtygdftvtllkveh...ldgytvrtlevtnnges..rtvthfqytgwpdhgvppslellleflelvrealael.p

SDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLKH
..  ... .. | ||.|.|..   ..| |. .  ....|.   .|.|||.|..|. ||.| | ..| . ...
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0051299 (Phosphotyrosine protein) phosphatases II 137-400 1.8e-36 121.5 In-house 20-285 (288) alignment 
Range on Protein: 137-400
Range on HMM: 20-285/288.0
EIRKLLEADFKPIDTMKVDLE-KCQAFKKNIDYCQSENVELYDANRVK----GGGEADFFYHATVTSIPSISTKsTILAQLPLsdsPHSLESFWLMVAAQ
   ..|.. |. .  ...||. .. ....|.. ... ..  || .|||    .| | . ...|   ... .. |  |..| ||   |...|.|| ||  |
ngltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPl...pntvedFWrmvweq

KIQRLFILIGEDELDKAALSEYFP-EDFKEFKTIRVNNRKTVSksdEQPNTQLYYEVVPK----DCAEAPFAMIEICDFWPDGKIPTvSYGRIAATAASV
...   .| ...||..     |.| ....... |.|.......   ..  |. . ||...     . |  . ..  .  |||  .|. |   . .    |
nvrvIvmltklvelgrekcaqYwplggsltygditvtllseev...lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd.spellldflrlv

FDSDIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
 ..  ... .... .. | ||.| |..   ..| |...  ... |.   .|.|||....|. ||.| | ..| |
rkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0047943 (Phosphotyrosine protein) phosphatases II 141-400 2.5e-36 121.0 In-house 13-271 (273) alignment 
Range on Protein: 141-400
Range on HMM: 13-271/273.0
LLEADFKPIDTMKVDLE-KCQAFKKNIDYCQSENVELYDANRVKGGGEADFFYHATVTSIPSISTKsTILAQLPLsdsPHSLESFWLMVAAQKIQRLFIL
||.. |. .  .|..|. .. ....|.|.... ..  || .||| |.. . ...|   . . .. |  |..| ||   |...|.|| ||  |... .  |
llleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrk.fiatqgPl...pntvedfwrmvweqnvrviVmL

IGEDELDKAALSEYFPED----FKEFKTIRVNNRKTVSksdEQPNTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIP--TVSYGRIAATAASVFDSDIDS
  ..||..     |.|..    ..... ..|..... .   ..  |.   |...... |  . ..  .  ||| ..|  . |  ..   . ... .....
telvelgrekcaqYwpleggelsltygkftvtllseet...kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

dATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
  . .. .. | ||.|.|..   ... |...  ....|.   .|||||....|. ||.| | ..| |
.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0046845 (Phosphotyrosine protein) phosphatases II 142-404 1e-34 115.6 In-house 2-277 (284) alignment 
Range on Protein: 142-404
Range on HMM: 2-277/284.0
LEADFKPIDTMKVDLE---KCQAFKKNIDYCQSENVELYDANRVKGGG-----EADFFYHATVTSIPS----ISTKSTILAQLPLsdsPHSLESFWLMVA
||..|. .  ..|.|.   .. ....|.. ... ..  || .|||        | . ...|   . ..    ...|  |..| ||   |...|.|| || 
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPl...pntvedFwrmvw

AQKIQRLFILIGEDELDKAALSEYFP--EDFKEFKTIRVNNRKTVSksdEQPNTQLYYEVVPKD-CAEAPFAMIEICDFWPDGKIP--TVSYGRIAATAA
 |... .  | ...| ..   . |.|  ....... ..|.....     ..  |.   |..... . |  . ..  .  ||| ..|  . .  ..  .. 
eqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev...kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr

SVFDSdIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGD---APNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLKH
..... .... . .. .  | ||.| |..   ..| |....    ... |.   .|.|||....|| ||.| | ..| | ...
ellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
DSPc_SM00195 144-400 1.4e-34 115.0 In-house 4-261 (263) alignment 
Range on Protein: 144-400
Range on HMM: 4-261/263.0
ADFKPIDTMKVDL-EKCQAFKKNIDYCQSENVELYDANRVKGGGE----ADFFYHATVTSIPsISTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFI
..|. ..... .   .....||| .  ...|. .|| .|||   |     . ...| . ...  ..|. |..| ||   |. .|.|| ||  .|..   .
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl...pstvedFWrmvweekvkiivm

LIGEDELDKAALSEYFPED---FKEFKTIRVNNRKTVSKSDEQPNTQLyyEVVPKDCAEAPFAMIEICDFWPDGKIPTVSyGRIAATAASVFDSDIDSDA
|  |.| .|   ..|.||.    ..|..|.|..... .|.||   ..|  |.  ... |. ..    .  ||| ..|      . .   .|  |   |..
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtl..eltkegkeetrkvtqyqyknWpdhgvpdst.ksvlellravkkskstssg

TCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
.. ...  | ||.|.|..   ...||.... ..|.||  ..|.||| ...|| || | | ..| |
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 144-400 1.4e-34 115.0 In-house 4-261 (263) alignment 
Range on Protein: 144-400
Range on HMM: 4-261/263.0
ADFKPIDTMKVDL-EKCQAFKKNIDYCQSENVELYDANRVKGGGE----ADFFYHATVTSIPsISTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFI
..|. ..... .   .....||| .  ...|. .|| .|||   |     . ...| . ...  ..|. |..| ||   |. .|.|| ||  .|..   .
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl...pstvedFWrmvweekvkiivm

LIGEDELDKAALSEYFPED---FKEFKTIRVNNRKTVSKSDEQPNTQLyyEVVPKDCAEAPFAMIEICDFWPDGKIPTVSyGRIAATAASVFDSDIDSDA
|  |.| .|   ..|.||.    ..|..|.|..... .|.||   ..|  |.  ... |. ..    .  ||| ..|      . .   .|  |   |..
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtl..eltkegkeetrkvtqyqyknWpdhgvpdst.ksvlellravkkskstssg

TCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
.. ...  | ||.|.|..   ...||.... ..|.||  ..|.||| ...|| || | | ..| |
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0042113 (Phosphotyrosine protein) phosphatases II 158-400 4.1e-33 110.2 In-house 2-242 (245) alignment 
Range on Protein: 158-400
Range on HMM: 2-242/245.0
KCQAFKKNIDYCQSENVELYDANRVKGGGEA----DFFYHATVTSIPSISTKsTILAQLPLSDsphSLESFWLMVAAQKIQRLFILIGEDELDKAALSEY
.......|.|....... .|| .|||   .     . ...|   . . |. |  |..| ||..   ..| || |.  ..|. .. |  |.||..    .|
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqy

FP-EDFKEFKTIRVNNRKTVSksdEQPNTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIPT--VSYGRIAATAASVFDSdiDSDATCAIVSNYGAGRAGS
.| ..........|..... .   ..  |. ..||... . |  . .   .  |||...|.   .  ..   . ..  .  ||. .... .. | ||.| 
wplgesltygdftvtllseeh...lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGt

FLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
|..   ..| |..    .. |.   .|||||.|..|. ||.| | ..| .
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0040439 (Phosphotyrosine protein) phosphatases II 159-401 5.6e-32 106.7 In-house 5-246 (249) alignment 
Range on Protein: 159-401
Range on HMM: 5-246/249.0
CQAFKKNIDYCQSENVELYDANRVK----GGGEADFFYHATVTSIPSISTKsTILAQLPLSDsphSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYF
.  ...|.|.... ..  || .|||    .|.. . ...| . . . |...  |..| ||..   ..|.|| |.  ..|. .  |  ..||..    .|.
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpe...tvedfwrmlwelgitvivmLtslvelgrekcaqyw

P-EDFKEFKTIRVNNRKTVSKSDeqpNTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIP--TVSYGRIAATAASVFDSDiDSDATCAIVSNYGAGRAGSF
| ....|.....|..... .|.|    |. . |.... . |    .   .  ||| ..|  . .  ..   . ...... ...  ... .. | ||.| |
plggsleygdftvtllsvevkdd...ytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtf

LVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYG
..   ..| |.     ...|.   .|||||.|.... ||.| | ..| . 
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 159-398 7.4e-29 96.4 In-house 4-239 (243) alignment 
Range on Protein: 159-398
Range on HMM: 4-239/243.0
CQAFKKNIDYCQSENVELYDANRVKGGGeaDFFYHATVTSIPsistKSTILAQLPLSDSPHS-LESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPED
.  .. |.. ..  .. .|| .||| .|  . ...|  . ..    .  |. |.||... .. |.||| |.  ..|. .  |  ..||..    .|.|..
iallpenlsknrysdilpydhsrvkleg..sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpge

FkEFKTIRVNNRKTVSKSDeqpNTQLYYEVVPKDCAEAPFAMIEICDF-WPDGKIPT--VSYGRIAATAASVFDS-----DIDSDATCAIVSNYGAGRAG
. ......|.. .. ...|    |. .......|. . ..  | .. . |||...|.   .  ..   . .. ..      .||. ....    | ||.|
v.tygdftvtllseehldd...ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

SFLVGVQAIEKLqagDaPNIKEIAMSIRSQRPC-AIETLPQYVFTYIIAL
 ...    ...|   .  .. |.   .|.|||. |..|. ||.| | ..|
tliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 149-411 4.8e-24 78.6 In-house 62-322 (346) alignment 
Range on Protein: 149-411
Range on HMM: 62-322/346.0
IDTMKVDLEKCQafKKNIDYCQSENVELYDANRVKGGGEADFFYHATVTSIPSIStKSTILAQLPLSDSPHSLESFWLMVAAQKIQRLFILIGEDELDKA
 |  .|.|..    .....| ..  . | |  |      |  .       |  .  .  |.||||  ..   .| || |.  ..|. ..... .| | ..
ydenrvqlnrpg..hedvnyinasvitlkdvsrrmacvpayvhlvvlyfvifqfe.hklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklknt

ALSEYFPED--FKEFKTIRVNNRKTVSKSDEQPNTqlyYEVVPKDCAEAPFAMIEICDFWPDGKIPTVSYGRIAATAASVFDSDIDSDATCaIVSNYGAG
. | .  |.  ..    . .|||..    | .  |    ||.|.  ...  . .     |   . |  .   |        . .. .   | .|| .|.|
ttslfndenggyqytgkmfinnrradvsgdpkeyt...ievlpegnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvc.vvslfgcg

RAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLKH---VKDPVLK
|| ||.  . ||..|. |  ||| ||  .|. ||| ..|...||   | | . |  ..    |.|| |
racsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggkkapvnk
0045098 (Phosphotyrosine protein) phosphatases II 159-402 2.6e-23 78.3 In-house 27-273 (278) alignment 
Range on Protein: 159-402
Range on HMM: 27-273/278.0
CQAFKKNIDYCQSENVELYDANRVKgggeaDfFYHATVTSIPsisTKSTILAQLPLSdspHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDF
.  . .|.| .   ..  || .|||     | . .|.  ...   .|  |..| ||    . ...|| |.  ..|. .  | .. ||..    .|.||. 
palylgnldknRykdilpydhsrVk.....d.YINAsyidgy...pkkfIatqgPlp...stvadfwrmlwelgitvivmltelvelgrekcaqywpegg

-KEFKTIRVNNRKTVSKsDEQPNTQLYYEVVPKDCAEAPFAMIEICD--FWPDGKIPTVSYGRIAATAASVFDSDID--------------SDATCAIVS
 .... ..|.. ..    |.   . |... .    .. . . ... .  .|||. .|. .. .    .    .. ..              |. ....  
sltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

NYGAGRAGSFLVGVQAIEKLqaGDAPNIKEIAMSIRSQRPC-AIETLPQYVFTYIIALTYGL
..| ||.| . .    .| |  ..  .. |.   .|||||. |...| ||.| |  .| . |
saGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 203-400 3.1e-19 64.2 In-house 50-241 (250) alignment 
Range on Protein: 203-400
Range on HMM: 50-241/250.0
STKSTILAQLPLSdspHSLESFWLMVAAQKIQRLFILIGEDELDKAaLSEYFP-EDFKEFKTIRVNNRKTVSKSDEQpNTQLYyeVVPKDCAEA-PFAMI
 .|. | .| ||.   ...| || ||  .|.. . .|    | .|   ..|.| |  ...  ..|.  ..  ..| .  ..|   .  .  |.      .
erkafiatqgPlq...atiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllskeefadyt.krklk..lskakkaderivrql

EiCDFWPDGKIPTVSYGrIAATAASVFDSDIDSDATCAIVS-NYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALT
.    |||  .| |    . .    |  |.  ....  ||    | ||.|.|..    .|.|.     .. ..   .| .|| |.|.| |||| | |.| 
h.fvvWPdkgvPevata.vLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk

Y
.
a
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 204-400 3.2e-19 64.3 In-house 98-289 (298) alignment 
Range on Protein: 204-400
Range on HMM: 98-289/298.0
TKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPE-DFKEFKTIRVNNRKTVSKSDEQpntQLYYEVVPKDC-AEAPFAMIE
... |..| ||   ....| || ||  ..|. . .|    ||||   ..|.|.   ... .|.|. ... ...|     .  ..|  |.   |    ...
rnafiatqaPl...tetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadli...vrklkvskkkeekerevrqlh

ICdFWPDGKIPTVSYGRIAaTAASVFDSDIDSD-ATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
    |||  .|...   ..   . |  |  ..  .   .    | ||.|.| .    .|....     . ..   .| .|| |..|  |||| | . | .
ft.sWpdkgvpenatsvld.llrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_PTPN13_pd Subfamily PTPN13 144-399 1e-18 62.6 In-house 15-267 (273) alignment 
Range on Protein: 144-399
Range on HMM: 15-267/273.0
ADFKPIDTMKVdLEKCQAFKK--NIDYCQSENVELYDANRVKGGGEADfFYHATVTSIP-SISTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILI
 .|| .  .|  |..|.  ||  | |  .  ||  ||. ||| |.|.  .  |.   .|    . . |..| ||   |.. . ||.||  || . . .. 
eefkelrelkp.ldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPl...Petvkdfwqmvweqkaeviamvt

GEDELDKAALSEYFPEDFKefKTIRVNNRKTVSKSDEQPNTQLYY-EVVPKDCAEAPFAMIEICDF--WPDGKIPTVSYGRIAaTAASVfdSDIDS-DAT
 | | .|     |.||  .  |.. |.|| .|.. . |   ..   ..  || . .    .   .|  ||| ..|. .   .   .| |    ...  . 
lekekgkvkchrywPeskn..kklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellq.fvaev..rrlqtdagP

CAIVSNYGAGRAGSFlVGVQAIEKLQAGD-APNIKEIAMSIRSQRPCAIETLPQYVFTYIIALT
 ..    | ||.|.. . ....  | . |   ..|||  ..| ||   . |  ||.| | ..|.
ivvhcsaGiGrsGtl.itidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 145-400 7.3e-18 59.7 In-house 20-275 (281) alignment 
Range on Protein: 145-400
Range on HMM: 20-275/281.0
DFKPIDTMKVDLEKCQA-FKKNIDYCQSENVELYDANRVKGGGEADF--FYHATVTSIPSIS-TKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILI
... .  . ||     .  ..|.   .  |.  ||| |||   . .     .     .|...  |  | .| |.   |.||..|| ||  ||.. . .. 
eyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPv...PaslvafWqmvweqkvsaivmvt

GEDELDKAALSEYFPEDFKEFKTIRVNNRKTvSKSDEQPNTQLYYEVVPKDCAEAPFAMIEICdFWPDGKIPTVSYGRIAATAASVFDSDIDSDATCAIV
 | | .|     |.|.| .| |   |  ..| ......   .  ...  ... .   . ..    |||  .|. .   .   ..    .. ...|.  | 
reieagklkChrYWPddnselkygdvtvkst.aeeekatyierkfkleresgetreveqlayt.aWPdhGvPattkellefrkevlkltekktkaplvih

SNYGAGRAGSFLVGVQAIEKLQA-GDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
   | ||.|...   .......|     ..|.. ...| .|   . |. || | | . | .
CsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Ptp69D_pd Subfamily Ptp69D 146-404 1.9e-17 58.4 In-house 28-289 (307) alignment 
Range on Protein: 146-404
Range on HMM: 28-289/307.0
FKPIDTMKVDLEKC-QAFKKNIDYCQSENVELYDANRVKG---GGEADFFYHATvTSIPSI-STKSTILAQLPLsDSphSLESFWLMVAAQKIQRLFILI
.. . . ..|..    . | |    ..|..  .| .|||     |..|  |      | .   .|. | || |. ..   .. || |.| |... . .| 
yekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYina.sfikgykekkkfiaaqdPv.ea..tigDfWRmiaeqevtlivmls

GEDELDKAALSEYFP-EDFKEFKTIRVNNRKTVSKSDeQPNTQLYYEVVPKdCAEAPFAMIEICDF----WPDGKIPTVSYGRIAAtAASVFDSDIDSDA
 ..| ...  . |.| || ...  | |.  .. ..||   . .|..  . . ..    .  ..  .    |.| |.| |. | .      | .    . .
nlteknrkkcakYWpiedevqygdilvklvseekhsd.yiiReldvskkke.esgevedsrkvvqyhytgWkDskvPevargllkl.ieqvrelyklnrs

TCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLKH
   .  . |.||.| |.     ...|.| |  .| |.   .||||.  .. | |||| |   | |  . 
PivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_PTPRA_pd Subfamily PTPRA 201-403 3.5e-16 54.0 In-house 96-297 (330) alignment 
Range on Protein: 201-403
Range on HMM: 96-297/330.0
SISTK-STILAQLPLSdspHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPED-FKEFKTIRVNNRKTVSKSDEqPNTQLYYEVVPKDCAEAPFA
    | . | || |..   ...| || |.  || . . .|   .| ..     |.|..    .  |||. ....   |     ..  . .|. . | .  
GykekdkfiaaqGPke...etvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdy.tvrkflvqqlpdatrekksr

MIEICDF--WPDGKIPTVSYGRIAATAAsVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYII
...   |  |||  .|. . | .   .. |   .  |  .  .    |.||.|.|.|  . .|...|    .. |.  ..| |||  . |. ||.| | .
lvrqfhftswPdvGvPfepiGmlkllkk.vkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykv

ALTYGLK
 | | | 
lleyyly
subfamily_PTPRD_pd Subfamily PTPRD 218-430 6e-16 53.2 In-house 101-309 (564) alignment 
Range on Protein: 218-430
Range on HMM: 101-309/564.0
PHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPED-FKEFKTIRVNNRKTVSKSDEQPNTqlyYEVvpKDCAEAPFAMIEICDF--WPDGKIPTV
....| || ||  |...   .|    | .|  ...|.||.  ...  . |.  ... ..| .  |    ..  |.  .    ...   |  |||  .|. 
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirt...fkl..kkkkssesreVrqFhFtsWPdhgvpes

SYGRIaATAASVFDSDiDSDATCAIV-SNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYgLKHVKDPVLKSK
  . . .    | ..   .|| . .|  . | || | |.|    .|.... .  .| .. . .|.||.  ..|  ||.| . . | . |.  .. |  ..
atslL.dlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailea.lacgntevesen

TEKVISQLEQFACEKMM
 .. ...|..   .. |
lkqhlqkLaeveedtem
subfamily_PTPN23_pd Subfamily PTPN23 159-400 9.1e-16 52.5 In-house 37-279 (288) alignment 
Range on Protein: 159-400
Range on HMM: 37-279/288.0
CQAFKKNIDYCQSENVELYDANRVKGGGEADFFYH-ATVTSIPSISTkSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPED
. . |.. .  .|...  || ||||  |. | .   . | .. . .  . | .| ||   . .|  |||||  || . . .|. ..||.|   ..|.|||
iaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcP.dfiatqaPl...qstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPed

FK---EFKTIRVNNRKtVSKSDEQPNTQLYYEVVPKDCAEAPFAMieICDFWPDGKIPT--VSYGRIAATAASVFDSDIDSDATCAIVS-NYGAGRAGSF
     .|. ..|  .. | ....  . .|  |. ..|  .    .      ||.  .|    .. ..   . | ...      |  .|    | ||.| |
kgetvkfgdlsvtlks.vretethvervlkletldadavksvshl..qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf

LVGVQAIEKLQAGDA-PNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
 . . |...|..|.  ..| ..   .| ||   ...  |. |.| . |..
alvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 159-400 3.9e-15 50.6 In-house 45-270 (288) alignment 
Range on Protein: 159-400
Range on HMM: 45-270/288.0
CQAFKKNIDYCqsenvelyDANRVKGGGEADFFYHATVTSipSIST-KSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPED
..   .|.  |        |. |||   ..||. .| | |  |    .  | || ||      .| .| |.  . .. . .|    |. | .  ||||  
trdryenlprc........ditrvklsddpdfyiaanvvs..sakykrrlicaqaPl...ngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

FKEFKTIRVNNRKTVSKSDE-QPNTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIPTV--SYGRIAATAasvfdsdIDSDATCAIVSNYGAGRAGSFLVG
  |   |. .   .  | .. .   ..    . |   |. .  |     |.|  .|    |. |.            . .    . |. |.||.| . . 
lGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqkPivvhssaGvGrtgtlili

VQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
. |.| |.  |   |...  . | .|  ||.|  ||.. . . | .
lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 125-407 9.9e-15 49.3 In-house 3-283 (307) alignment 
Range on Protein: 125-407
Range on HMM: 3-283/307.0
VKTWVEQL-EKLVeiRKlLEADFKPIDTMKVDLEKCQAFKKNIDYCQSENVELYDANRV--KGGGEADFFYHATVTSIpSISTKSTILAQLPLSDSPHsl
|| ||..  .| |  .. |  .|. .  .. .    .||. | |  . ..|.  | .|.  |  | |  . ||    | .|  |  | || || .. .  
vkpwvqrtldkgv..qa.lvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgi.aikpkkficaqgplentqy..

eSFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDF-------KEFKTIRVNNRK--TVSKsDEQPNTQLYYEVVPKDCAEApFAMIeICDFWPDGKIP
 ||| |.  .|.. . .|    || |    .|.| .        .. .|| |.|    ...  ||.       .|.  . . .    .   . |||  .|
.sfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklap.dedlinvttlkvdwaqksrt.iqhl.qwenwpdrgvp

TVSYGRIAATAASVFDSDidsdaTCAIVSNYGAGRAGSFlVGVQA-IEKLQAGD-APNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLKHVKD
 .  . |    |  .| .        .    | ||.|.  |..    .|. ||    ..|..   .||||. ||.|  ||.. . . | | |.  |.
qinltainlleavrydtn.....pvvvhcsaGvGrsGti.vaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyke
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 136-403 2.2e-14 47.9 In-house 18-289 (305) alignment 
Range on Protein: 136-403
Range on HMM: 18-289/305.0
VEIRKLLEADFKPIDTMKvDLEKCQAFKKNIDYCQ--SENVELYDANRVKGGGEADF-FYHATVTSIPSiSTKSTILAQLPLSDSphsLESFWLMVAAQK
    . | |.|. .  .. |.|| .|||.  .  .    .|   | ||||  |     . ||   | |.  .|  | .| || ..      || |   .|
ekgpaglraefvamkrfn.dfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstpt.npkrfictqaplekt...cadfwymclqdk

IQRLFILIGEDELDKAALSEYFPEDFKEFKTIRVNNRKTVSKSDEQPNTQL--------YYEVV--P-KDCAEAPFAMIEICDfWPDGKIPTVSYGRIaa
.. .|.|    |      .|||. . |.  ... ...| . | .   . ..           |.      .     .     | |||  .|.     .  
veaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwid.wpdrgvpaadlail..

taaSVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAP-NIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLK
    ..     |    ..    | ||.|| ..    ...| ||.   . . | . || ||  .|.|  ||.| . . | | .|
...ellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 203-400 2.3e-14 48.2 In-house 87-279 (318) alignment 
Range on Protein: 203-400
Range on HMM: 87-279/318.0
STKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPED-FKEFKTIRVNNRKTVSKSDeqpNTQLYYEVVPKDCAEAPFAMIE
..|. | || ||   |. .| || ||  |. . . .|  | |  || .  |.|..  .......|. ...|. ||    .   ..|  ... |       
rkkayiaaqaPl...petieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsd...yvlrefkvtrteeeesrqvrqy

ICDFWPDGKIPTVSyGRIAATAASVFDSDIDSDATCAIVS-NYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
 .  |||  .|. . . . .   .|   . .|.|.. .|    | ||.| |..    .|...|    .. .. . .|.||.  . |  ||.| | . | .
hytsWpdegvpesg.aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_PTPN14_pd Subfamily PTPN14 144-400 5e-14 47.0 In-house 27-295 (300) alignment 
Range on Protein: 144-400
Range on HMM: 27-295/300.0
ADFKPIDTMKVDL-EKCQAFKKNIDYCQSENVELYDANRVKGGG----EADFFYHATVTSIPSISTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFI
...  |  .. |   .. . ..| .  . ..|  |. |||.       . ..   ...    . ...| | || ||   .. .. || ||  |..| . .
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl...eltvqdfWqmvWeqgvqlivm

LIGEDELDKAALSEYFPEDFK-----EFKTIRVNNrKTVSKSDEQPNTQLYYEVVPKDcAEAPFAMIEICDfWPDGKIPT-----VSYGRIAATAASVFD
|  | |  |    .|||.. .     ||.  .| . | ...||    |.|  . .|    |    ..   | ||| ..|      .|| .        ..
lteeeedgkeksfkyfPkleskkktvefgkfkvtt.kfsedsdsvittglklkhlpsk.eertvwhlqytD.WpdhgvPeDvkgflsyLeevqsvrrktn

SDID---SDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
| ..   |.    .    |.||.|  ..    |. |. ..  .||..   .| ||   ..|| || | | . ..|
seveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 144-407 1.5e-13 45.0 In-house 34-295 (305) alignment 
Range on Protein: 144-407
Range on HMM: 34-295/305.0
ADFKPIDTMKVDLEKCQAFKKNIDYCQSENVELYDANRVKGGGEAD-FFYHATVTSIPSISTKSTILAQLPLSdspHSLESFWLMVAAQKIQRLFILIGE
| .   |  .| ..  |. . .|   . ..|   | . ||    .   . ||     | |  |  | || ||    .... || ||  .|.... .|   
akytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpld...qtidefwwmviqnkveqivmlckt

DELDKAALSEYFPEDFKEFKTIR----VNNRKTVSKSDEQPNTQLYYEVVPK-DCAEAPFAMIEICDfWPDGKIPTVSYGRIAATAAsVFDSDIDsdatC
 || |   ..|.|    | ....    |.|       . ... |.    .      .     .. .. |||  .| .    .   .| .  | .      
velgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwte.wpdrgvppckltslellsa.irgskvp....i

AIVSNYGAGRAGSFLVGVQAIEKLQ-AGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLKHVKD
 .    | ||.|. .     .||.    ..| . |.  ..| ||  .|..  ||.| . . | | |.. |.
vvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 201-400 1.5e-13 45.5 In-house 69-267 (274) alignment 
Range on Protein: 201-400
Range on HMM: 69-267/274.0
SISTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDFKE-----FKTIRVNNRKTVSKSDEQPN-TQLYYEVVPKDcae
.  .|  . .| ||   |. .. ||.|.  ...| . .|    | ...  ..|||.. .      .. . ....|.|.. | . .   | |   ...   
deeskayvatqGPl...pntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers...

apfAMIEICDFWPDGKIPTvSYGRIAATAASVFDSDIDSDATCA---IVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYV
    .      ||| | |  .   .  . . | .|  ...| .|   .    | ||.| |.    |. .|..    .. .|   .| .|   ..|  || 
...vkhywytdWPdhksPd.dantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqye

FTYIIALTY
. . .   |
lihralcly
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 143-395 1.7e-13 45.4 In-house 25-277 (305) alignment 
Range on Protein: 143-395
Range on HMM: 25-277/305.0
EAD-------FKPIDTMKVDLEKCQAFKKNIDYCQSENVELYDANRVKgggEADFFYHATVTSIPsiSTKSTILAQLPLSDsphSLESFWLMVAAQKIQR
||.        ..||  | . .| .   |.| . . . . |   . ..   ..|.   . | .    . |. |.|| || .    .. || ..   |.. 
eaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekesld...dsdyinasyvdgyk..rkkkyivaqgPlkn...tvadfWrliveekvst

LFILIGEDELDKAALSEYFPEDFKE---FKTIRVNNRKTVSKSDEqPNTQLYYEVVPKDCAEAPFAMIEICDfWPDGKIPTVSYGRIAAtAASVFD-SDI
. .| .  | .|     |.||  .|   |  . |. . . . ||   . .|   .  .|  .      .. | |||  .|. .   .      |      
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdy.ieRklkisiededkesrtvlqyqltd.WPdhGvpqfatsllsl.ikrvqkdqkk

DSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYI
| . .  .. . | ||.| |..   |.|.|.. .  .. |.   .||.|. ...|| |||| . 
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhd
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 202-398 1.7e-13 45.3 In-house 87-276 (288) alignment 
Range on Protein: 202-398
Range on HMM: 87-276/288.0
ISTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDFK--EFKTIRVNNRKTvsKsDEQPNTQLYYEVVpKDCAEAPFAM
 ..|  | .| ||   ..... || .|  .|.. .  | .  | .|    ||.|.. |  ..  . |  ...  | ...  ..   ... |.  |     
kkkkkyiatqgPl...adtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlves..k.eledfvlrkllle.kkkteleitq

IEIcDFWPDGKIPTVSYGRIAATAAsVfDSDIDSD-ATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIAL
 .    ||| ..|  .   ..     | .   ..|     ..   | ||.| |..  ..|..... |  .. ..   .| ||.  ..|| ||.| | . |
yqy.laWpdhgvPeskapllellrq.v.kvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN1_pd Subfamily PTPN1 162-416 3.6e-13 43.9 In-house 29-285 (290) alignment 
Range on Protein: 162-416
Range on HMM: 29-285/290.0
FKKNIDYCQSENVELYDANRVKGGGEADFFYHATVTSIPSIsTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDFK--
...| .  .  .|. ||  |.|   .   .  |..  .. .  .| ||.| ||   |.  . ||.||  || . . .|    | ..    .|.|.. .  
lpenrnlnryrdvspydhsrikleradndyinaslveleea.krsyiltqGPl...pntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeek

EFKTIRVNN-RKTVSKSDEQPNTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIPTvSYGRIAATAASVFDSDI-DSDATCAIV-SNYGAGRAGSFLVG--
|..   ..   | .|. ...  |   .|.  . . |.   .      |||  .|  | .        | .|    ||   |..    | ||.|.| .   
ellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpe.spaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt

-VQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIiALTYGLKHVKDPVLKSKTEK
 .  ||| .  .. .||.  . .|..|   | |  |  |.|. |.  | | .|..    |. |
clvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl.aileGakvikgdssvqkrwk
subfamily_PTPN3_pd Subfamily PTPN3 162-393 3.6e-13 44.1 In-house 38-267 (280) alignment 
Range on Protein: 162-393
Range on HMM: 38-267/280.0
FKKNIDYCQSENVELYDANRVKGGGEA-DFFYHATVT-SIPSIST-KSTILAQLPLSdspHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDF
  .|..  .  ..  ||| |||   .  |.    .|   ||| .. .  | .| ||.   .. . || ||  ||.. . .|    |  .    .|.||  
kpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPla...ktatdfWqmvweqksslivmlttlverGrvkChqyWPete

KEFKTIrvnNRKTVSKSDEQPNTQLYYEVVPKDCAEAPFAMIEICDF--WPDGKIPTVSYGRIAATaASVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQ
.|..     . . . ..... .. .. |.| || ..    .|    .  ||| ..|. |   .  .  .| .    ..    .    | ||.| ...   
deleyg...efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefv.ervrklrsgkeePvvvhCsaGigrtGvlillet

AIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFT
|. ...| .. .. .|   .| || . ..|  || | 
alalieaaepvypldivrtmrdqramlvqtasqykfv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 160-397 4.9e-13 43.3 In-house 42-275 (303) alignment 
Range on Protein: 160-397
Range on HMM: 42-275/303.0
QAFKKNIDYCQSENVELYDANRVKGGGEAdfFYHATVTSIPsiSTKSTILAQLPLSdspHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPE--D
. | ||.|  .  .|   |  .||    .  . ||.   .   |.| .||.|||||   |.   || |.  ||.. ...|. . | ||      ||.  |
nqfvknmdknrfvdvicldhskvklsdss..yihasyleld..sskkailtqlpls...htaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

FKEF--KTIRVNNRKTVSKSDEQpntQLYYeVVPKDCAEAPFAMIEICDFWPDGKIPTVSY---GRIAATAASVFDSDIDSDATCaIVSNYGAGRAGSFL
| .|  ..||| . | |  .|     .|   .   .     |  .   . || ..||. .     .      ||.    ||  |   .|  | ||||.| 
flkfeersirvgefkrvelgdgw...vlkv.lsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptv.ymslsgcgragtfa

VGVQAIEKLQAGDA-PNIKEIAMSIRSQRPCAIETLPQYVFTYIIA
.   |   |.. .|  ..      .|  |  |.. | |. . | . 
lfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 167-400 2.3e-12 41.4 In-house 46-276 (315) alignment 
Range on Protein: 167-400
Range on HMM: 46-276/315.0
DYCQSENVELYDANRVKG-----GGEADFFYhatVTSIPSIST-KSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPE---D
   . .|.  .| .|||        . |..     . |.|. . |. | .| ||   . |.. || ||  .|.  . ..   .| ||     |.|.   |
kknryknilPldsarvkleviddsPdsdyin...asyiksvdddkayiasqgPl...kasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

FKEFKTIRVNNRKTVSKSDEQpNTQLyyeVVPKDCAEAPFAMIEICDfWPDGKIPTVSYgRIAATAASVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQA
  || .|.|.  .. . .|   . .|   |. |  .    .  .  . |||  ..  .   .      |  ..   . .  .    |.||.| ..   . 
svefGsikvellsleadtdgv.arkl...vtrkseesrtvtqfqfte.wPdkGvdkqts.sllklikevkadngkkefsllvhcsaGvGrtGvvisidev

IEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
..... ... .. ..   .|..||  . |  .| | | . | .
vaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_PTPRB_pd Subfamily PTPRB 145-394 5.2e-12 40.4 In-house 30-278 (293) alignment 
Range on Protein: 145-394
Range on HMM: 30-278/293.0
DFKPIDTMKVDLEKCQA-FKKNIDYCQSENVELYDANRVKG-----GGEADFFYHatvTSIPS-ISTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLF
... . ... | .. .|  ..| .  . .|.  ||..|||        ..|.        ||   |..  | .| ||   |.... || ||  .| . . 
eyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYina...nyipgynsprefiatqGPl...petvddfWrmvwekkssiiv

ILIGEDELDKAALSEYFPEDFKEFKTIRVNNrkTVSKSDEQPNTQLYYEVVPKDCAEAPFAMIEIcDFWPDGKIPTVSYGRIAATAAsVFDSD--IDSDA
.|    |  |    ||.|.| ..     ..   |. ...|. .  .    . |. .|      .    |||  .|  .   .. . . | ..     |..
mltqlvekgkvkCeeYWPadeepvlyGdikv..tlvaeeeledwvirelkiekekeerkvrqyhf.tsWpdhgvPektktlldfvrt.vreaiektaskr

TCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTY
   .    | ||.| |.   . .....  |  .|  | ...|..| . . |  ||.| .
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifih
PTPc_DSPc_SM00012 305-397 7.1e-12 40.8 In-house 9-103 (105) alignment 
Range on Protein: 305-397
Range on HMM: 9-103/105.0
FWPDGKIPTVSyGRIAATAASVFDSDIDSD--ATCAIVSNYGAGRAGSFLVGVQAIEKLQAG-DAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIA
 ||| ..|. |   |  . ..| ..  .|.  . . ...  |.||.| | .   ....|... . ..|..|  ..|.||| ...|. ||.| | . 
gwpdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
subfamily_PTPN12_pd Subfamily PTPN12 204-399 1e-11 39.3 In-house 82-275 (290) alignment 
Range on Protein: 204-399
Range on HMM: 82-275/290.0
TKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDFKE---FKTIRVNNRKTVSKSDEQPNTQLYYEVVpkdCAEAPFAMI
... | || ||   |. |. || |.  .... . ..  | ||.|     |.||  .|   | ...|.. .    .|.    .|  |.     ..  .  .
kleyiaaqgPL...pktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqf

EIcDFWPDGKIPTvSYGRIAATAASVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDA---PNIKEIAMSIRSQRPCAIETLPQYVFTYIIA
.    |||  .|. |  .. .  ..| .   ..||  ..    | ||.|  ..   . | |.|.      .. .. ...| ||.... |  ||.. |   
hY.taWPDhgvPs.saksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykav

LT
. 
ae
0036282 (Phosphotyrosine protein) phosphatases II 204-394 2.7e-11 39.0 In-house 16-163 (174) alignment 
Range on Protein: 204-394
Range on HMM: 16-163/174.0
TKSTILAQLPLSdsphslesFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEdfkefktirvnnrktvsksdeqpntqlyyevvpKDCAEAPFAMIEIC
|.  |. | ||.        || |.  ..|. .. |. | ||..     |.||                                 .   . .. .  ..
tprliagqgpla........fwemlkelgittvvmlleekelglykcinywpe.................................lredlerlgiqyly

DFWPDGKIPTVSYgrIAATAASVFDSDID-SDATCAIVSNYGAGRAGSFLVGVQAIEKLQaGDAPNIKEIAMSIRSQRPCAIETLPQYVFTY
  |||.  |..|   .      | .   . .. ....  . | ||.| . .    .  |   .. .. ..  ..|.|||....|  || | |
lpwpDhgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
0046846 (Phosphotyrosine protein) phosphatases II 216-396 3.2e-11 38.8 In-house 31-168 (176) alignment 
Range on Protein: 216-396
Range on HMM: 31-168/176.0
DSPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEdFKEFKTirvnnrktvsksdeqpntqlyyevvpkdcaeapfamIEICDFWPDGKIPTVs
. |..|..|. |.  ..|. .. |  | ||..  .  |.|| .....                                       ..  |||. .|.  
plprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi....................................qylhlpwpDhgvpdl.

ygRIAATAASVFDSDIDSDATCAIVSNYGAGRAGSFLVGVqaieKLQAGDAPNIKEIAMSIRSQRP-CAIETLPQYVFTYII
  ..  ..    .. .... . ..    | ||.| ...       |. .   .. |.   .|.||| .|..|  || | |  
..elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyef
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 138-399 9.2e-11 36.3 In-house 21-281 (319) alignment 
Range on Protein: 138-399
Range on HMM: 21-281/319.0
IRKLLEADFKPIDTMKVDLEKCQAFKKNIDYCQSENVELYDANRVKGGG---EADFFYhATVTSIPSISTKSTILA-QLPLSDsphSLESFWLMVAAQKI
  .||| .|| ... . |  .    ..| .  . .|.  ||  ||.        .  |    . | .   ..  .| | ||..    .| || ||  ...
getllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdy.inasfidgyqerekfiatqaPlen...tiedfWrmvWeees

QRLFILIGEDELDKAALSEYFPEDF-KEFKTIRVNNRKTvSKSDEQPNTQLYYEVVPKDCAEapfAMIEICDF--WPDGKIPTVSYGRIAaTAASVFDSD
  . .| .  |  |  |..|.||   .|.  . |.  .   . ..    .|  .    .       ..    .  ||| ..|. . . ..     .  | 
sivvmltklveklkvklkkywpeenfeeyGrlivtleee.eeledyiirklklnkkssevet...RevkhfqyteWpdhdvPekatslld.llkrirksr

IDSDAT-CAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALT
  ...    .    |.|| |.|.|   ..|...   . .. ...  .| ||.. ...  || | | . | 
ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 171-400 1.4e-10 34.9 In-house 49-275 (515) alignment 
Range on Protein: 171-400
Range on HMM: 49-275/515.0
SENVELYDANRVKG-----GGEADFFYhatVTSIPSIST-KSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPE---DFKEF
 .|.  || .|||        . |.|     . |||. . |. | .| |.   . |.. || .|  ...  . ..    | ||   ..|.|.   |  .|
yknilPydsvrvklevindnPhsdyfn...asyipsfdndkayiasqgPn...kasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

KTIRVNnrkTVSKSDEQPNTQLYYEVVPKDCaEAPFAMIEICDfWPDGKIPTVSYGRIAATaASVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQAIEKL
 .|.|.   .|| .     ..   .|.  |      .  .  . |||  .|  .   .      |  .      .  |    |.||.| ..   . . . 
Gsikve...lvsleactggikrkltvlkgdd.srtvtqfhfte.WPdkGvpkhtssllkli.kevkadhgqythpliihcsaGvGrtGvvisidsvvaha

QAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
. ... .. ..   || .||  . |  || | | . | .
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_PTPRK_pd Subfamily PTPRK 205-399 2.1e-10 34.9 In-house 86-275 (314) alignment 
Range on Protein: 205-399
Range on HMM: 86-275/314.0
KSTILAQLPLSDsphSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDFKEFKTIRVNNRKTvskSDEQPNTQLYYEVVPKDCAEAPFAMIEICD
.  | .| || .    .. || .|  ..   . .|    |  .   ..|.||| . .. |.|.  .|   . ..   .  . |     .   . ..   .
aafivtqgPlqe...tvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvet...ellaelvvrifrveklargqeeirevrqfq

F--WPDGKIPTVSYGRIAAtAASVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALT
|  ||| ..|.   | ..   . |  |. ...    .    ||||.| |..    .. ..  .  .. ... ..||...  .||  ||.| | ..| 
flgWpdhdvPvsatgllkl.vrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 141-400 5.3e-10 33.5 In-house 20-275 (312) alignment 
Range on Protein: 141-400
Range on HMM: 20-275/312.0
LLEADFKPIDTMKVDLEkCQAFKKNIDYCQSENVELYDANRVKGGGEADFFYHATVTSIpsiSTKST--ILAQLPLSDSphsLESFWLMVAAQKIQRLFI
 |  ..| .  .  | | | || |  |  .  |.. .|  |    |. .|. ||    |    ||    . .| || ..      || .. .     . .
qltkeykavgnivsdse.ctaflkfkdlnrypniqcwdrgrftlagdenfyihanfvki...ctkperfvctqgplent...cthfwqlalslgstsiil

LIGEDELDKAALSEYFP--EDFKEFKTIRVNNRK-----TVSKSDEQPNTQLYYEVVPKDCAEAPFAMIEICdFWPDGKIPTVSygriaATAASVFdSDI
|.|  |      ..|      | ...  ||            || ..   ..   ||     |. .   . .  |||  .|         ||  .. | .
lcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwa.swpdhgmpdsc.....dtalrll.sav

DSDATCAIV-SNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
  |    |     | ||.|.. .    |  |.     |.|.. . .| .|  .....||||..  . | .
kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_PTPRG_pd Subfamily PTPRG 207-396 5.4e-10 33.1 In-house 93-282 (563) alignment 
Range on Protein: 207-396
Range on HMM: 93-282/563.0
TILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDF-KEFKTIRVNNRKT--VSKSDEQpNTQLYY--EVVPKDCAEAPFAMIE
 | .| ||   .. .. || |.  |. . . ..    |  .     |.|.|  .......|.  ..  .. . .. . ..        |.| .    .  
fiatqgpl...kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvr.tlviknlklkkkkqcdteklvrqy

ICDFWPDGKIPTVSYGRIAATAASvfdSDIDSD-ATCAIV-SNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYII
 .  |||   |. |   .     |   |    . |   .|  ..|.||.| ..|    ....|. .| |. ...  ||.||.  ..|  ||.| . .
hytkWPdhgvPehslpvLifvkks...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhda
0051429 (Phosphotyrosine protein) phosphatases II 218-400 6e-10 34.7 In-house 32-224 (272) alignment 
Range on Protein: 218-400
Range on HMM: 32-224/272.0
PHSLESFWLMvAAQKIQRLFILIGEDELDKAALSEYFP-------------EDFKEFKTIRVNNRKTVSKSDeqPNTQLYYEVVPKDCAEAPFAMIEICD
|.. ..|| . . ..|   . | .|.|...   . | |             . . ..  .|| . ... ..|       .. .   .  ||.  |.  . 
pltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld..yilrellltlllsagearevmhlhyt

FWPDGKIPTVSYGRIAATAASvfdsdidsDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPN--------IKEIAMSIRSQRPCAIETLPQYVFTYII
 |||  .|. .. .. .  ..        .  . .  . | .| | . . .  .. . . .  .        . |.   .|.|||.|..|  ||.| | .
dwpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea

ALTY
.| .
llel
0041856 (Phosphotyrosine protein) phosphatases II 165-400 9.3e-10 33.9 In-house 1-170 (182) alignment 
Range on Protein: 165-400
Range on HMM: 1-170/182.0
NIDYCQSENVELYDANRvkgggeadffyhatvtsipsisTKSTILAQLPLSDSPH------------SLESFWLMVAAQKIQRLFILIgedeldkaaLSE
|.|.   ...  || .|                        . |.| | |.. |.            ....|. |.  ..|. .  |             
nldknrysdilpydhsr......................dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eel

YFPEDFkefktirvnnrktvsksdeqpntqlyyevvpkdcaeAPFAMIEICDFWPDGKIPTvsygriAATAASVFDSDIDSDATCAIVSNYGAGRAGSFL
|.||..                                        .  .. .|||. .|.        .. .  .  .... ....  ..| ||.|.. 
ywpell....................................erlgiqylylpwpDhgvpd......ldelldfieevleeggpvlVHCsaGvgRtgtlv

VGVQAIEKlqagdAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
.    ...       .. |.   .||.||....|. ||.| . ..| .
aaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_PTPN9_pd Subfamily PTPN9 204-403 1.3e-09 32.5 In-house 84-292 (297) alignment 
Range on Protein: 204-403
Range on HMM: 84-292/297.0
TKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFP---EDFKEFKTIRVNNRKTVSKSDEQPNTQLYYEVVPKDCAE-APFAM
 |. | .| ||   ..  . ||.||  |..  . .     |  .   ..|.|   |. .||  ..|.| ......| . ..   ..|  ..  .   | .
kkafiatqGpl...kktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqf

IEICDF-WPDGKIPTVSYGRIAATAASVFDSDIDSD-----ATCAIV--SNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYV
.   |.  |.     .   . .  . ... ... ..         ||     | ||.| |     ....|.  .  .. |    .|.||  .| |  ||.
lsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqye

FTYIIALTYGLK
| |.  | | |.
fcylavleyale
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 208-400 1.3e-09 32.5 In-house 67-263 (270) alignment 
Range on Protein: 208-400
Range on HMM: 67-263/270.0
ILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDFKEFKTIRVNNRKTVSKSDEQPNTQLYYEVVPKDCAEAPFAMIEICDFWP
| |. ||   | .|.||| |.  .| . . .. |  |  .   . |.|.. ||  ...  . |... |.|. .  .  ..  .. .|    .      ||
iaamgPl...pttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWp

DGKIPTVSYGR-----IAATAASVFDSDIDSD-ATCAIV-SNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
|  .|. . .      . .. . |  |  . | |.  .|    | ||.| ...  .|.. |.     .. .|   .| .|.  ...  || | |   ..|
dhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 210-397 1.3e-09 32.4 In-house 97-275 (315) alignment 
Range on Protein: 210-397
Range on HMM: 97-275/315.0
AQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDfkefktIRVNNRKTVSKSDEQPNTQLY---YEVVPKDCAEAPFAMIeiCDFW
|| |.   . |.. || .|  ..| .. .| .  | .|    .|.|..        .  . ||.. .|. ||..    . || .|  .  . .      |
aqgpn...vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk......kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlh..ytsw

PDGKIPTVSYGRIAaTAASVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIA
|| ..|  .   .      |   . .| ..  .  . | ||.|.|.     .....| .| .. ..   .|..|  ..... || | | . 
pdmgvpkytiplmn.lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
0049772 (Phosphotyrosine protein) phosphatases II 166-400 1.7e-09 33.3 In-house 47-279 (314) alignment 
Range on Protein: 166-400
Range on HMM: 47-279/314.0
IDYCQSENVELYDaNRVKGGG----EADFFYHATVTSIpsistKSTILAQLPlsdSPHSLESF----------WLMV--AAQKIQRLFI-----------
.|   . ..  .| |||. .|      |..    | ..     .. | .| |   ... ...|          | ||    ...  . .           
rdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgp...leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LIGEDELDkaalSEYFPEDFKEFKtirvnnrktvsksdeqpntqlyyEVV--PKDCAEAPFAMIEIcdFWPDGKIPtvSYGRIAATAASV
          |.. |..     .|. ..|....|                       |..  |... .. .  . |   .|||  |  .   . .  . .
rLdaAlgKtpllildgng....neptaadlellk.......................eelydpelferlgikylri..pvpDgsap..lledfdeflefi

FDSdiDSDATCAIVSNYGAGRAGSFLVGVQAIEKLqagDApNIKEIAMSIRSQRP-----CAIETLPQYVFTYIIALTY
 .   | .   ..  . | ||.|.|.|    . .|   .  ...|.   .|..||      .||.| ||.| . . | |
eea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_CG7180_pd Subfamily CG7180 150-402 2.9e-09 31.0 In-house 25-291 (296) alignment 
Range on Protein: 150-402
Range on HMM: 25-291/296.0
DTMKVDLEKCQA--FKKNIDYCQSENVELYDANRV---KGGGEADFFYHATVTSIPSISTKSTILAQLPLSdspHSLESFWLMVAAQKIQRLFILIGEDE
 | ... ..|..   |.|..  .  .|  || |||   | .||..  |  .|     .  |  |  . |     .....|| .|  ..|. . .|  . .
ltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkk...etvdefWrlvydeeisavvvLtktfd

LDKaALSEYFPED-FKEFKTIRVNNRKTVSKSD-EQPNTQLYYEVVPKDC----AEAPFAMIEIC--DFWPD-GKIPTVSYGRI--AATAAsVFDSDI--
  |    .|.|..  .... | |.  .. . .. .. . .|. ..|         .|.  ..       |.   |.| .. . |     .  ..   .  
fak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvr.lwrekvde

-DSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGL
 .  .   .||. ||.|.| .|    ..|...  .  .. | .  .| .||  .|.  .| . | . | . |
dpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 171-394 3.3e-09 31.3 In-house 9-232 (237) alignment 
Range on Protein: 171-394
Range on HMM: 9-232/237.0
SENVELYDANRV--KGGG-EADFFYHATVTSIpSISTKSTILAQLPLSDsphSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPED--FKEFKTIR
  |.  || .||  || | ..|.   . . ..   . |. | || ||     | . || ||  .|   . .| |  | ..    .|.|.    . .  . 
ygnivaydhsrvvlkgagsgsdyinatylkgf.dgtpkkyiaaqgples...scddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvlt

VNNRKTVSKSDEQPNTQLyyevVPKDCAEAPFAMIEICDF--WPDGKIPTVSYGRIAATAASVFDSDIDSDATCAIVSN-YGAGRAGSFLVGVQAIEKLQ
|  .|    ||    . |    . |        .|   .|  |||  .|  .   .      .  |   |...  |.    | ||.| |||    . . .
vslkkkeefsdytvrsll....lskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

AGDAPNIKEIAMSIRSQRPCAIETLPQYVFTY
     .| .   ||  .||  |.|  |||| .
ekkvvdiynyvysieedrpyiiqtkdqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 221-398 3.7e-09 31.1 In-house 64-237 (239) alignment 
Range on Protein: 221-398
Range on HMM: 64-237/239.0
LESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDFKEFKTIRVNNRKTVSKSDEQPNTQLYYEVVpkdCAEAPFAMIEICDFWPDGKIPTVSYGRIA
   || |.  ..   . .| |  |  |    .|.|.   ..  .||  |||   .|    | .  .|     .|  .        |||  .|  .   . 
sgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvg...qteeryvyqyhftvwpdkgvpqyatavlg

ATAASVFDSdIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIAL
       || .       |  . | ||.|.|||    . . .   . .| .   .|| .||  ..|  |||| ..  |
lrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 221-397 4.1e-09 30.9 In-house 65-237 (239) alignment 
Range on Protein: 221-397
Range on HMM: 65-237/239.0
LESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDFKEFKTIRVNNRKTVSKSDEQPNTQLYYEVVpkdCAEAPFAMIEICDFWPDGKIPTVSYGRIA
   || |.  ..   . .| |  |  |    .|.|.   ..  .||  |||   .|    | .  .|     .|  .        |||  .|  .   . 
sgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvg...qteeryvyqyhftvwpdkgvpqyatavlg

ATAASVFDSdIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIA
       || .       |  . | ||.|.|||    . . .   . .| .   .|| .||  ..|  |||| ..  
lrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
0049260 (Phosphotyrosine protein) phosphatases II 218-394 7.4e-09 31.0 In-house 19-143 (152) alignment 
Range on Protein: 218-394
Range on HMM: 19-143/152.0
PHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFpedfkefktirvnnrktvsksdeqpntqlyyevvpkdcaeapfamIEICDFWPDGKIPTVSYG
|..|..|| |.  ..|. .  |  ..||.|    .|.                                               .. .|||.  |. |  
pntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwpDhgvpdlsql

RIAATAASVFDsDIDSDATCAIVSNYGAGRAGSFLVGVQAIeklqagDAPNIKEIAMSIRSQRPCAIETLPQYVFTY
 . .  .  .   .|.. ....   .| ||.| . .    .         ...|.   .|..||.|...  |. | |
llflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 165-400 9.7e-09 29.8 In-house 51-283 (297) alignment 
Range on Protein: 165-400
Range on HMM: 51-283/297.0
NIDYCQSENVELYDANRVKG-----GGEADFFYHATvtsIPSISTkSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKaALSEYFPE-DF
|..  . .|.  || .|||        ..|..  .    ....     |  | |    . ... || ||  .... . .|  ..| ||     |...   
nfeksRYkniLPydssRvkLaivnddpdsDyvnasf...vkgnkh.rlittqmPm...katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

KEFKTIRVNnrkTVSKSDEQPNTQLYYEVVPKDCAEApfAMIEICDF--WPDGKIPTVSYGRIAATAASVFDSDIDSDAT--CAIVSNYGAGRAGSFLVG
..| .. |    . | |. .   .   ||   .       ...  .|  ||| ...     .      |    | .. |     .    | ||.| .|  
ttfGdvsvv...llsvsereGfikrelevtkgkakar..rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllti

VQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
 . . . .  .. .| ..   .| .||  . |  || | | . | .
dsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
0043147 (Phosphotyrosine protein) phosphatases II 204-394 1.1e-08 30.5 In-house 19-154 (172) alignment 
Range on Protein: 204-394
Range on HMM: 19-154/172.0
TKSTILAQLPlsdSPHSLESFWLMVAAQKIQRLFILIGEdeldkaalseyfpedfkefktirvnnrktvsksdeqpntqlyyevvP-KDCAEAPFAMIEI
... |  | |    .. |..|| |.  ..|. .. | ..                                                    . .. .  .
pdrfiatqgp...lrntladfwrmlkelgithivnltel..............................................lydpellerlgiqyl

CDFWPDGKIPtvSYGRIAATAASVFD-SDIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLqagdapNIKEIAMSIRSQRPCAIETLPQYVFTY
.  |||.  |  .   .  .   . .   .... ....   .| ||.| . .    ...|      .. |.   .|..||.|...  || | |
ylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyrfly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 160-401 1.3e-08 29.1 In-house 30-270 (285) alignment 
Range on Protein: 160-401
Range on HMM: 30-270/285.0
QAFKKNIDYCQSENVELYDANRVKGGGEADFFYHATVTSIPSISTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIG--EDELDKAALseYFPED
 |.. | |  .  .|   .  ||        . ||.   .|     . | .| ||   | .|  || |.  .||  ...|    |  ..|.||  |.|| 
tayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgpl...petlsdfwhmiyqekiayvlmlctlfeggvekcal..yypek

FKEFKTI-RVNNRKTVSKSDEQPNTQLYYEV--VPKDCAEAPFAMIEI-CDFWPDGKIPTVSYGRIAAtAASVFDSDIDSDATCAIVSnYGAGRAGSFlV
. |   . . .   |  | .    | |        .|..  |. |  .   .|||   |  .   |      |   .      |  .|  | ||. .| |
lgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmiel.ykwvkkvnpkekpicvhcs.agvgrtatf.v

GVQAIeKLQAGDAPNIK--EIAMSIRSQRPCAIETLPQYVFTYIIALTYG
|..    ..  . |||.  .|   .|. |  |...  |..| |.. . | 
gidya.tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 205-400 2.5e-08 28.1 In-house 91-282 (290) alignment 
Range on Protein: 205-400
Range on HMM: 91-282/290.0
KSTILAQLPLSDsphSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPED-FKEFKTIRVNNRKTVSKSdEQPNTQLYYEVVPKDCAEAPFAMIEIC
|. |..| |.|.    |  || ..  .|.  . .|. . | .|     |.|.   |..  ....  .  . . |  ...|  .   .. |.      .| 
kqyiatqgpvsn...tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqit

DFWPDGKIPTvsYGRIAATAASVFDSDIDSDATCAIV-SNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
 . ..||..   .  |  . . . .    .  |  .|    . ||.. |..   .|.| .     .. ..  | |.|.|  ..|  || . . | |||
nwdstgkvtn..pqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 141-400 3.3e-08 28.2 In-house 35-293 (319) alignment 
Range on Protein: 141-400
Range on HMM: 35-293/319.0
LLEADFKPIDTMKVDLEKC--QAFKKNIDYCQSENVELYDANRVK-----GGGEADFFYHATVTSIPsiSTKSTILAQLPLsdsPHSLESFWLMVAAQKI
 ||..|. .  . |.| .      ..| |  .  |.  .| |.||     |   .|.   . ||     . .  | || ||   . .|. || |.  ...
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq..rkdkyiaaqGPl...dntladfWrmiweync

QRLFILIgedeldKAALSEYFPEDFKEFKTIRVNNRKTVSKSDEqpNTQLYYEvVPKDCAEAPFAMIEICDF--WPDGKIPTVSYGRIAATAA-SVFDSD
  . .|       |   |.|.| . .. .     . ..| ...|   .   .| . .|  |     |    |  |||   |  .   .      . . | 
stivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdie.lsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk

IDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALT---Y
 .  |   .    |.||.| ..|    .....  .  .. ..   .| ||.  .. | || | |.  |    .
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 164-400 5.4e-08 27.2 In-house 46-277 (287) alignment 
Range on Protein: 164-400
Range on HMM: 46-277/287.0
KNIDYCQSENVELYDANRVKGGGEADFFYHATVTSIpSISTKSTILAQLPLSDsphSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDF----K
.| |  .....  .| .||   || . .  |.       . |  |.|. |...    .  || ..  .... . .|  | | |. .  .|.||.      
qnkdknRltqilvpdnyrvllkgehpdyinavfidg.ykekkafiiaesPmfn...tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlG

EFKtIRVNNRKtvsKSDEQPNTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIPTvsYGRIAATAASVFDSDIDSDATCAIV-SNYGAGRAGSFLVGVQAI
|.. |.. |..   ....  . .|  .   |. ..      .| ..   ||...  .  |       . ..  .  |  .|    . ||.. |.    .|
eyn.iellnee...vnagyierklevknknkagdkqqvkqyqitnWdstgkvte..pqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaatti

EKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTY
.| .   . .. ..  | | |.| .. |  || | . | |.|
nkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 158-399 5.5e-08 27.0 In-house 26-264 (283) alignment 
Range on Protein: 158-399
Range on HMM: 26-264/283.0
KCQAFKKNIDYCQSENVELYDANRVKGGGEADFFYHATVTSI--PSISTKSTILAQLPLSDSphsLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFP
.... ..|  . . ...  .| .||.   |.  .  |.   .       |  | || || .       || ||  .||  . .|    |  . . | |.|
diasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrt...vvdfWkmvfdekitaivmltklqedlrikCsqyWP

E----DFKEFkTIRVNNrKTVSKSDEQPNTQLYYE-VVPKDCAEAPFAMIEICDFWPDGKIPTV-SYGRIAATAASVFDSDIdsdatcAIVSNYGAGRAG
.    |. || |. ...  | |.|  . .  | ..    .    | . .|.  .. ..  | ..  . .. .      .. |       .    | ||..
krGsedyGef.tvtlrk.ettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPi......vvhCstgiGrta

SFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALT
 |.  . .......    .. ..   .| ||. |. || || . . ..| 
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 174-402 5.9e-08 27.6 In-house 34-259 (284) alignment 
Range on Protein: 174-402
Range on HMM: 34-259/284.0
VELYDANRVK-----GGGEADFFYHATVTSIPsiSTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIgedeldKAALSEYFPEDFKEFKTIRVNN
.  .| |.||     |   .|.   . .|     . .  | .| ||   . .|. || |.  ...  . .|       |   |.|.| . .. .     .
ilafdknvvklerliGeefsdyinasfitGyq..rkdkyiatqGPl...dntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvk

RKTVSKSDEqpNTQLYYEvVPKDCAEAPFAMIEICDF--WPDGKIPTVSYGRIAATAA-SVFDSDIDSDATCAIVSNYGAGRAGSFLVGVQAIEKLQAGD
 ..|..|.|   .   .| . .|  |     |    |  |||   |  .   ..     . . |  .  |.  .    |.||.| ..|    .....  .
vdsveesee..yvvrdie.lsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeek

APNIKEIAMSIRSQRPCAIETLPQYVFTYIIALT---YGL
  .. ..   .| ||.  .. | || | |.  |    .| 
qvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 128-397 1.8e-07 24.9 In-house 10-275 (439) alignment 
Range on Protein: 128-397
Range on HMM: 10-275/439.0
WVEQLEKlvEIRKLLEADFKPIDTMKVDLeKCQAFKKNIDYCQS----ENVELYDANRVKG---GGEADFFYHaTVTSIP-SISTKSTILAQLPLSDsph
 ||.|.|  . .....  |. |.... |  .|.|     .| |.    ..|  .|  ||      |     |  .   |      |  | .| |  .   
hvekldk..nkqeifkeifekinstspdy.aciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyi.nanyikGyyddklyiatqgpkke...

SLESFWLMVAAQKIQRLFILIGEDELDKaalseYFPEDFKEF-KTIRVNNRKTVsksdEQPNTQL-YYEV-VPKDCAEAPFAMIEIC-DFWPDGKIPTVS
. ..|| .|  .|  ..  |    |  |     |.| | . .   | |   . .    | ||  .  . |   .| .|   .....    ||| ..|. .
ttddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrni....elpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqa

yGRIAATAaSVFDSDIDSDATCAIVS--NYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIA
   .        .|  |.. .  .|     | ||.|. .    |.|.|.. .  .|| |   .| ||   ...| |||| |   
.shvldfl.rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_PTPN6_pd Subfamily PTPN6 194-400 2e-07 25.3 In-house 87-296 (306) alignment 
Range on Protein: 194-400
Range on HMM: 87-296/306.0
ATVTSIPSISTKSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDFKEFKT--IRVNNRKTvSKSDEQPNTQLYyeVVPKD
  ...    |.|| | .|  |   .. .. || ||  .. . . ..  | |  |   . |.|.  .. ..  |.|.| .  .. ..    .|   |  |.
nyikkevkgsdksyiatqgcl...ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRels..vskkk

CAEAPFAMIEI-CDFWPDGKIPTVSYGrIAATAASVFDSDID---SDATCAIV-SNYGAGRAGSFLVG---VQAIEKLQAGDAPNIKEIAMSIRSQRPCA
 ..    ...     |||  .|.  .  . .    |     .   ..|   .|  . | || |.|.|    .. |||       .|... .|.|.||   
kkkeerevfqyhfksWPdhgvpkdpga.vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsgl

IETLPQYVFTYIIALTY
. |  || | | .  .|
vqteqqykfvykaikky
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 165-413 2.3e-07 25.2 In-house 48-300 (325) alignment 
Range on Protein: 165-413
Range on HMM: 48-300/325.0
NIDYCQSENVELYDANRV-----KGGGEADFfYHATvtSIPSISTKST-ILAQLPLsdsPHSLESFWLMVAAQKiQRLFILIGEDELDKAALSEYFPED-
|..  . .||  .| .||     |  ...|. . |.   . .   | . . || ||   ..... .| .|   .   . ... | .|.|   . |.|.. 
nkaknrfknvvaldksrvvletkkddpssdy.inas..ylrddkkkdvflaaqaPl...tatindlWrlvldWr.csvvvvlneldlgkdrcavywpkem

--FKEFKTIRVNNRKTVSKSDEQpntQLYYEVVPKDCAEAPFAMIEICDFWPD---GKIPT--VSYGRIAATAASVFDSDIDSDATCAIVSNYGAGRAGS
   |.| ...|. |     ||     .  ..|   .  |.          |.|    | |.  .|. ..  .      ..  . .   .    | ||.| 
gksktfGglevklrtieeisdyv...hrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

FLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGLKHVKDPVLKSK
|.    |..|.      .| .    .| .||  .||  ||.. |     . .    |  . | 
fislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 339-395 4.3e-07 24.2 In-house 197-253 (267) alignment 
Range on Protein: 339-395
Range on HMM: 197-253/267.0
IVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYI
.  . | ||.|.|||    .|...  .  .| .  . |||||.  ..|. .|.. . 
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihe
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 339-399 5.2e-07 23.8 In-house 233-293 (297) alignment 
Range on Protein: 339-399
Range on HMM: 233-293/297.0
IVSNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALT
.    | ||.|  .     ..||. .  |... |   .|.||.  ..|| |. . | ..| 
vhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 266-397 5.6e-07 23.4 In-house 196-332 (347) alignment 
Range on Protein: 266-397
Range on HMM: 196-332/347.0
VNNRK-TVSKSDEQPNTQLYYEVVPKDCAEAPFAMIEICDFWPDGKIPTVSYGRIAATAASVFDSD------IDSDATCAIVSNYGAGRAGSFLVGVQAI
.| |. .| .   .   .   ||| . |.|| || .  |  ||  | |      .|   | | .|       ..  |   .. . |  |. . ..    |
intravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiii

EKLQAGDAPNIKEIAMSIRSQRPCAIeTLPqYVFTYIIA
|.. .| .|.  ..   .| ||   . |.    .|| | 
eqvldgktpdcddlfkkmrdqragvf.tms.ifytyair
0044763 (Phosphotyrosine protein) phosphatases II 208-392 2.2e-06 22.9 In-house 26-162 (178) alignment 
Range on Protein: 208-392
Range on HMM: 26-162/178.0
ILAQLPLSDSPHslESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDFKefktirvnnrktvsksdeqpntqlyyevvpkdcaeapfaMIEICDFWP
||  | |.. |.  .... .. ...|. .  | .|.|| .  . .|.||..                                        .  ..  .|
ilpglylgslpp..addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipip

DGKIPTVSYGRiaATAASVFDSDI-DSDATCAIVSNYGAGRAGSFLVGVQAIEKlqagdAPNIKEIAMSIRSQRPcAIETLPQYVF
|.. |...       .    .. . ... ....  ..| ||.|.. .    ..        .. |.   .|..|| ....  |. .
Dhgvpdllehf..lefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 158-402 3.2e-06 21.0 In-house 53-284 (290) alignment 
Range on Protein: 158-402
Range on HMM: 53-284/290.0
KCQAFKKNidycQSENVELYDANRV--KGGGEADFFYHATVTSIpsisTKSTILAQLPLSDSphsLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFP
|   ||||    .  .|   |  ||  | |.. |. .   |  .        ||.| .| |.      .| ||  .|.  . .|    |  ||  ..|.|
kntefkkn....rykdvvcndktrvilkdGydGdyvhanyvkGl....kamfiltqGalkdt...vidiwrmvlqekvaaivmlceliedGkakceqyyp

EDFKEFKTIRVNNRKTVSKSDEQPNTQLY-YEVVPKDCAEAPFAMIEICDFWPDGKIPTVSYgRIAATAASVFDSdidsDATCAIVSNYGAGRAGSFLVG
|   |  |.         ..|.. |...    |  ||              |||  ..  .   .  |  ..           ..    | ||.|.|   
ekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstl.allrtlrilrka....sGpvvvhcsaGiGrtGtfvai

VQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQYVFTYIIALTYGL
  ... |  | . .. ..  ..|  |  ...   ||.    | | .| 
evglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 192-403 5.2e-06 20.3 In-house 69-271 (281) alignment 
Range on Protein: 192-403
Range on HMM: 69-271/281.0
YHATVTSIPSIsTKSTILAQLPLSDSphsLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDFK---EFKTIRVNN-RKTVSKSDEQPNTQLYYEv
 ||     | .  .  ||.| |  ..      || |.  ..   . .|    | ..   .|||| . .   .|  . |.    || ||      .| || 
ihanyirspfl.krgyiltqgpkket...radfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye.

vpkdcAEAPFAMIEICDFWPDGKIPTVSYGRIAataasVFdSDIDSDATC-AIVSNYGAGRAGSFLVGVQAIEKLQAG-DAPNIKEIAMSIRS-QRPCAI
      |. .    .   ||| ..|  |   .      ..   | . .|   |    | ||.|...    |.. ...    |.||.|   .|   | ...
.....getrlithwlwkewpdwqvpessevmlk.....il.rkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasv

ETLPQYVFTYIIALTYGLK
.|| ||.. . . | .|. 
qtlqqymliwkvlldfgva
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 199-400 7.7e-06 19.9 In-house 73-276 (287) alignment 
Range on Protein: 199-400
Range on HMM: 73-276/287.0
IPSIST-KSTILAQLPLsdsPHSLESFWLMVAAQKIQRLFILIGEDELDKAALSEYFPEDfkeFKTIRVN--NRKTVSKSDEQPNT-QLYYEVVPKDCAE
..|    .. | || |.   . .. .|| .|  ..   . ..  | |  .    .|.||     . .||       ....  .|.     . ..  .  |
vasytddeafiaaqgPi...aatvrdfwravletrsasvitmtreveearlkcykywPer...evPmrvGGysvvlldydikePeygvralrlidletre

APF-AMIEICDfWPDGKI-PT-VSYGRIAATAASVFDSDIDSD-ATCAIV-SNYGAGRAGSFLVGVQAIEKLQAGDAPNIKEIAMSIRSQRPCAIETLPQ
|     ... . |||. . || |.. | .       .   |.. .   .|  . |.||.| .|  .  ...|.     ..  . . .| .| . . .  |
arvvkqldlls.wPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvq

YVFTYIIALTY
. ..|    ||
lrllyealvty
0051082 (Phosphotyrosine protein) phosphatases II 212-396 8.8e-06 20.9 In-house 15-148 (151) alignment 
Range on Protein: 212-396
Range on HMM: 15-148/151.0
LPLSDSPhsLESFWLMVAAQKIQRLFILIGEDELDkaALSEYFPEDFkefktirvnnrktvsksdeqpntqlyyevvpkdcaeapfamIEIC-DFWPDGK
| .|. |  |. |. ... ..|.  . | .|.| .   . ||.||                                           ||..   ..| .
lyrsggp..ladflellkelgiktivnlrseeerg..ycpeylpelg.........................................ievlhipildwp

IPTvsYGRIAATAASVFDSDIDS-DATCAIVSNYGAGRAGSFLVGVQAIEKlqagdaPNIKEIAMSIRSQRPCAIETLPQYVFTYII
 |.     . ........  .|  .  ...  . | || | . . .  ...       .. |.   .|..|| .. .  |..| .. 
dpg..lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa