Gene C04F12.8 in Caenorhabditis elegans

Synonym: CELE_F13D11.3, F13D11.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP14
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP011_AA protein Get Run
CeleP011_AA_8-150 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP14_pd Subfamily DSP14 9-160 4.3e-70 228.7 In-house 5-156 (157) alignment 
Range on Protein: 9-160
Range on HMM: 5-156/157.0
GQMSEINDHLYLSGAGVLKPDKIKQRKINMIVNATTEEPSTYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIY
 ..|.|...|.|||...|.....|..||..|.|.|.| |.| .......|...||.| |.|..||| |||||..||..||||||||.|||||||||...|
aalsqitpsLflsgvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

LVKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRLRGTASVKMVQTP
|.|.|...||.||..||.||||||||||||||..||||.|.|..|||||..|
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmvdsp
PTPc_motif_SM00404 11-146 1.3e-39 130.3 In-house 2-139 (140) alignment 
Range on Protein: 11-146
Range on HMM: 2-139/140.0
MSEINDHLYLSGAGVLK-PDKIKQRKINMIVNATTEEPSTY-MQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIY
.|.| .||||...   . |...|. .| ...|.|.| . |. ..|.  ..| ..|.  . ||...| |.| |.|....||| ||||.|||||||.|.. |
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LVKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEK
| . ....|..||..||  ||||.||..|..|...|||
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP10_pd Subfamily DSP10 10-151 3.8e-38 124.9 In-house 13-156 (159) alignment 
Range on Protein: 10-151
Range on HMM: 13-156/159.0
QMSEINDHLYL-SGAGVLKPDKIKQRKINMIVNATTEEPSTYMQ-GVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMI
..|..  .|.| |. .  . | ... .|....| ||. | .. . ..  ..| ..|     |...|..  . | .....| . ||||.||.||||..|. 
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLVKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRLRGT
||.|| ...|..||..|| .|||| ||..|  |....||.|. .
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
subfamily_DSP1_pd Subfamily DSP1 13-149 5.7e-38 124.6 In-house 20-157 (163) alignment 
Range on Protein: 13-149
Range on HMM: 20-157/163.0
EINDHLYLSGAGV-LKPDKIKQRKINMIVNATTEEPSTYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVK
.| |.||| .. |  . . .|. .|  |.|...| . .. .    .|. .||.| | .|..|. | . | .||. .|| |.|| ||.|||..|...||.|
kildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmk

HEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRLR
.....| .|...||  |.||.||.|| .|...|||.| 
tkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0044763 (Phosphotyrosine protein) phosphatases II 9-150 6.6e-37 122.2 In-house 21-172 (178) alignment 
Range on Protein: 9-150
Range on HMM: 21-172/178.0
GQMSEINDHLYLSGAGVLK-PDKIKQRKINMIVNATTEEPSTYMQG---------VDTMKIRIEDHPYARLSEHFDVVADKIRNVK-ERGGKTLVHCMAG
  .||| ..|||....  . .. .|. .|..||| |.| .  ...          .  ..| |.||.   |.|||. . . |...  |.||..||||.||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

VSRSASLVMIYLVKHEHMTLRQAYHYVKAARPiIRPNVGFWKQMVDYEKRLRG
|.||..||..||.|. ...| .|...|...|| | || |...|. ..|.||..
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP19_pd Subfamily DSP19 10-148 1.5e-36 120.0 In-house 11-150 (152) alignment 
Range on Protein: 10-148
Range on HMM: 11-150/152.0
QMSEINDHLYLSGAGV-LKPDKIKQRKINMIVNATTEEPSTYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIY
...|....|||.   |  . ...|..||  |.| .|. | .. . . ...| | |.| ..|..... . | |.....  |  |||| ||||||||.|. |
evgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviay

LVKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRL
|.|.|...|..|...|..||| |.|| ||.||. .||..|
lmkkeelsleealelvrearpcikPneGFikqLkeyeael
DSPc Dual specificity phosphatase, catalytic domain 18-146 5.5e-36 118.4 Pfam-A 1-132 (133) alignment 
Range on Protein: 18-146
Range on HMM: 1-132/133.0
LYLSGAGVLKPDKIKQRKINMIVNATTEEPS---TYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHEH
|||...   ....... .|....|.|.| |      ..  . ..| .||.  . .|.... . . |......|.| ||||.||.||||.|.. || | ..
lylgskstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

MTLRQAYHYVKAARPIIRPNVGFWKQMVDYEK
..|..||..||  |..|.||.||..|...||.
lslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 18-146 5.5e-36 118.4 In-house 1-132 (133) alignment 
Range on Protein: 18-146
Range on HMM: 1-132/133.0
LYLSGAGVLKPDKIKQRKINMIVNATTEEPS---TYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHEH
|||...   ....... .|....|.|.| |      ..  . ..| .||.  . .|.... . . |......|.| ||||.||.||||.|.. || | ..
lylgskstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

MTLRQAYHYVKAARPIIRPNVGFWKQMVDYEK
..|..||..||  |..|.||.||..|...||.
lslneAyefvkerrskispnagflrqLleyer
0048076 (Phosphotyrosine protein) phosphatases II 11-148 2.7e-33 110.0 In-house 4-142 (145) alignment 
Range on Protein: 11-148
Range on HMM: 4-142/145.0
MSEINDHLYLSGAGV-LKPDKIKQRKINMIVNATTEEPSTYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYL
.||| ..|||..  . |. . .|. .| ...| |.|..  . .|.  . . ..||.   |.|... . . |... ..||..||||.|||.|...||..||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

VKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRL
.......| .|...|...||.. ||.|..... ..|..|
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Slingshot_pd Subfamily Slingshot 6-149 8e-33 107.2 In-house 14-158 (169) alignment 
Range on Protein: 6-149
Range on HMM: 14-158/169.0
GVLGQMSEINDHLYLSG-AGVLKPDKIKQRKINMIVNATTEEPSTYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASL
| | . |.| ||.||       . ...|..... |.| | |  . . . .. ..||. |.. . | ....   . |...|..| | ||||  ||||||| 
gqldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsast

VMIYLVKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRLR
|. | .|. ...| .|..|||  | .|.|| ||.||.  ||  |.
viayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGile
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 13-147 6.4e-32 104.1 In-house 9-146 (148) alignment 
Range on Protein: 13-147
Range on HMM: 9-146/148.0
EIND-HLYLSG-AGVLKPDKIKQRKINMIVNATTEEPSTY-MQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYL
|| | .|.|      .. ...|.  .  ||||| | . ..  .|.. ......|.|   ||  |. ... .|..|..|.. |||.  |||||. |....|
eikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwl

VKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKR
.......|..|. .|| .|. ..|| || ||. ..|..
idfkrvslkealalvkskrryvdpnlgfLkqLaeleqa
0041856 (Phosphotyrosine protein) phosphatases II 11-150 2e-31 104.4 In-house 19-174 (182) alignment 
Range on Protein: 11-150
Range on HMM: 19-174/182.0
MSEINDHLYLSGAGV---------------LKPDKIKQRKINMIVNATtEEP----STYMQGVDTMKIRIEDHPYARlsehFDVVADKIRNVKERGGKTL
...||..|||..                     . .|...|..|||.| ||.      . .|.  ... ..||.       .| . | |. |.|.||..|
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCMAGVSRSASLVMIYLVKHEHMTLRQAYHYVKAARP--IIRPNVGFWKQMVDYEKRLRG
|||.|||.|...||..||.|. ...|..|...|. .||  .|.|| .|. |.. .|..|..
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
0048179 (Phosphotyrosine protein) phosphatases II 11-148 2.3e-31 103.8 In-house 4-144 (144) alignment 
Range on Protein: 11-148
Range on HMM: 4-144/144.0
MSEINDHLYLSGAG-VLKPDKIKQRKINMIVNATTEEPSTYMQ--GVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMI
.||| ..|||..   .|. . .|. .|....| |.| . ...   |.  ... ..||.   |.|... . . |... |.||..||||.|||.|...||..
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLVKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRL
||.|.....| .|...|...||.. || |..... .|||.|
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
0043147 (Phosphotyrosine protein) phosphatases II 30-149 2.1e-30 101.1 In-house 39-161 (172) alignment 
Range on Protein: 30-149
Range on HMM: 39-161/172.0
KIKQRKINMIVNATTE---EPSTYMQGVDTMKIRIEDHPYArLSEHFDVVADKIRN--VKERGGKTLVHCMAGVSRSASLVMIYLVKhEHMTLRQAYHYV
 .|...|..|||.|..    .  . .|.  . . ..||.   |.|... . . |..  ....||..||||.|||.|.. ||..||.. ....| .|...|
mlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalv

KAARPIIRPNVGFWKQMVDYEKRLR
...||.. .| .....  ..||.|.
rekRpgavqnpsqyrflyyfeklll
subfamily_DSP6_pd Subfamily DSP6 13-149 1.8e-29 96.3 In-house 16-155 (158) alignment 
Range on Protein: 13-149
Range on HMM: 16-155/158.0
EINDHLYLSGAG-VLKPDKIKQRKINMIVNATTEEPSTYMQG--VDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYL
|| ..|||  |    . . .|. ||. ..| |.. |... .   .  ..| ||||  . |...|    . | . ...  | ||||.||.|||  ... ||
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlayl

VKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRLR
.|.....| .||..||. .. | ||  | .|..|.|..||
mkklalslndaydlvkkrksnisPnfnfmgqlldferslr
subfamily_DSP12_pd Subfamily DSP12 10-146 4e-29 96.0 In-house 1-141 (155) alignment 
Range on Protein: 10-146
Range on HMM: 1-141/155.0
QMSEINDHLYLSGAGV-LKPDKIKQRKINMIVNATTEEP---STYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLV
..|.|.. |||.|.    .... |. ||. ..  ..||    .. .. |.| .| | |.| . . .|.| . | | .  |..|. ||||.||||||...|
evsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiv

MIYLVKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEK
. ||.|.|.. | .|.. ||...| |.|| || .|.  .||
iAYlmkkeklslekAlklvkekkpeiepNegFleQLklfek
subfamily_DSP8_pd Subfamily DSP8 12-150 1.9e-28 93.0 In-house 16-156 (159) alignment 
Range on Protein: 12-150
Range on HMM: 16-156/159.0
SEINDHLYL-SGAGVLKPDKIKQRKINMIVNATTEEPS-TYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYL
 .| ..||| |   ||. . ...  |....|| .. |.   .. .  ... ..|.   .|.. ||   . |  .|.  |. |||..|| ||||.... |.
trilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayi

VKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRLRG
.|. .|.| .||..||  || | ||. | .|...|||.|. 
mktlemsldeayrfvkekrptispnlnflgqLleyekelkl
subfamily_DSP15_pd Subfamily DSP15 11-147 3.6e-28 92.6 In-house 2-138 (151) alignment 
Range on Protein: 11-147
Range on HMM: 2-138/151.0
MSEINDHLYLSGAGVLK-PDKIKQRKINMIVNATtEEPSTYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYL
.|..   |||..  . |  ...|...|  |..   ...  ... ..   |...| | | ||..|.   . | . . .... ||||.||||||. ||..||
iskvlpglylgnfrdskdeelLkeknithilsvh.dnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

VKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKR
.   ..  |.| . .|||| .  ||.|| .|. .||| 
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
0046846 (Phosphotyrosine protein) phosphatases II 9-149 5e-28 93.4 In-house 10-173 (176) alignment 
Range on Protein: 9-149
Range on HMM: 10-173/176.0
GQMSEINDHLYLSGAgvlkP---------------DKIKQRKINMIVNATTEE-----------PSTYMQGVDTMKIRIEDHPYARLsEHFDVVADKIRN
. ...||..|.|...    |               . .|. .|...|| |.|            |  .  |.  . . ..||    | |... . . ||.
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefire

VKERGGKTLVHCMAGVSRSASLVMIYLVKH-EHMTLRQAYHYVKAARP-IIRPNVGFWKQMVDYEKRLR
. ..||..||||.||..|.. ||..||...  .... .|...|.. ||  . .. .....  ..|..|.
alkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
PTEN_1 13-149 5e-28 93.2 In-house 43-192 (196) alignment 
Range on Protein: 13-149
Range on HMM: 43-192/196.0
EINDHLYLSGAGVLK--PDKIKQRKINMIVNATTEEPS---------TYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKE--RGGKTLVHCMAGVS
|| ..||.  .  .    |  |...| ..|| . ||.           . .||   .. ||||.   |||.||.... |  ...  .|.. |||| ||..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSASLVMIYLVKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRLR
||. .|. ||.... .| ..|  .|...|| ..|| ..... . |...|.
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0049772 (Phosphotyrosine protein) phosphatases II 32-148 5e-28 94.1 In-house 167-273 (314) alignment 
Range on Protein: 32-148
Range on HMM: 167-273/314.0
KqrkinmivNATTEEPSTYMQGVDTMKIRIEDhPYARLSEHFDVVADKIRNVkERGGKTLVHCMAGVSRSAS-LVMIYLVKHEHMTLRQAYHYVKAARPi
|        . ... .    .|.  . | ..| . | |.|.|| . . |... ..||..||||.||..|... .|. ||.|. ...|..|...|...|| 
k........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.

IRPNVGFWKQMVDYEKRL
|.|| ||..|  .||..|
inpnpgfieqleqyefil
0045098 (Phosphotyrosine protein) phosphatases II 8-149 1.9e-27 91.8 In-house 19-272 (278) alignment 
Range on Protein: 8-149
Range on HMM: 19-272/278.0
LGQMSEINDHLYLSGAG------------------------------------------VLKPDKIKQRKINMIVNATTEE-------------------
||..|||...|||...                                               . ... .|. ||..|...                   
lgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

------------------------------PSTYMQGVDTMKI-RIEDHPYARLS--EHFDVVADKIRNVKE--------------RGGKTLVHCMAGVS
                              .. .  ||  ...  ..||    |.   .|. . . ||.. .              .||..||||.|||.
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSASLVMIYLVKHE---HMTLRQAYHYVKAARPI-IRPNVGFWKQMVDYEKRLR
|.. ||..||...    ...| .|.....  ||. . .| ...... ... .|.
RtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0049260 (Phosphotyrosine protein) phosphatases II 30-149 2.1e-27 91.1 In-house 28-150 (152) alignment 
Range on Protein: 30-149
Range on HMM: 28-150/152.0
KIKQRKINMIVNATTEEPSTY---MQGVDTMKIRIEDHPYARLSEHFDVVADKIRN-VKERGGKTLVHCMAGVSRSASLVMIYLVKhEHMTLRQAYHYVK
 .|. .|. ||. |.... ..    |.   . . ..||.   ||.... . . |.   ...||..||||.|||.|.. ||..||..  ...| .|. .|.
mlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvr

AARPIIRPNVGFWKQMVDYEKRLR
..||.. || |....  ..|| |.
ekRpgavpnpgqlrflyefekllk
subfamily_MKPLT_pd Subfamily MKPLT 15-148 5.9e-27 88.2 In-house 26-160 (164) alignment 
Range on Protein: 15-148
Range on HMM: 26-160/164.0
NDHLYLSGAGVLKPDKI-KQRKINMIVNATTEEPSTYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHE
.|.|||  |   . .|. |. ||. ||| ..|. . . . |. .....|| .  .||.... .|. . .  . ||. ||||  |.|||.|  . .|.| .
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

HMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRL
  ||..||.|.|  | |..|| || ||.  .|. .
gwtlkeayeylkerrsivapnrGflkqlakfeeli
subfamily_MKPLV_pd Subfamily MKPLV 15-148 5.9e-27 88.2 In-house 26-160 (164) alignment 
Range on Protein: 15-148
Range on HMM: 26-160/164.0
NDHLYLSGAGVLKPDKI-KQRKINMIVNATTEEPSTYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHE
.|.|||  |   . .|. |. ||. ||| ..|. . . . |. .....|| .  .||.... .|. . .  . ||. ||||  |.|||.|  . .|.| .
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

HMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRL
  ||..||.|.|  | |..|| || ||.  .|. .
gwtlkeayeylkerrsivapnrGflkqlakfeeli
subfamily_DSP3_pd Subfamily DSP3 10-149 8.1e-27 87.9 In-house 10-158 (162) alignment 
Range on Protein: 10-149
Range on HMM: 10-158/162.0
QMSEINDHLYLSGAGVLK-PDKIKQRKINMIVNATTE-------EPSTYM-QGVDTMKIRIEDHPYARLSEHFDVVADKIRN-VKERGGKTLVHCMAGVS
.. |. ..||.... | |  .|.|.  |  ..||.         ... |   ..  . . ..| | . ||..|. .|. |.. .... || ||||..|||
evdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvs

RSASLVMIYLVKHEHMTLRQAYHYVKAARPIiRPNVGFWKQMVDYEKRLR
||| ||. ||. ...||| .| . |.. | | .|| || ||.......|.
RsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeelk
0037934 (Phosphotyrosine protein) phosphatases II 13-147 3.4e-26 87.7 In-house 41-240 (243) alignment 
Range on Protein: 13-147
Range on HMM: 41-240/243.0
EINDHLYLSGAG---------VLKPDKIKQRKINMIVNATTEE---------------------------------------------PSTYMQGVDTMK
.. ..|.....              . ... .|..||. |...                                             .  . ...  . 
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

IRIEDH---P-YARLSEHFDVVADKIRN-----VKERGGKTLVHCMAGVSRSASLVMIYLVKHE-HMTLRQAYHYVKAARPI-IRPNVGFWKQMVDYEKR
. . ||   .  . | ...| | . |..     .  .||..||||.|||.|.. |...||...  ...| .|...... ||  . .. .....  .... 
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle
0036282 (Phosphotyrosine protein) phosphatases II 11-150 6.4e-26 86.5 In-house 12-171 (174) alignment 
Range on Protein: 11-150
Range on HMM: 12-171/174.0
MSEINDHLYLSGAGVLKPDKIKQRKINMIVNATTEEPST---------------YMQGVDTMKIRIEDHPYARLSEhFDVVADKIRNVKER--GGKTLVH
.|.|...|.....     . .|. .|...|. ..|..                 .  |.  ... ..||    ||. .. . . .... ..  ||..|||
lsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CMAGVSRSASLVMIYLVKHEHM-TLRQAYHYVKAAR---PIIRPNVGFWKQMVDYEKRLRG
|.|||.|.. ||..||... .. .|..|...|...|   | . .. .....  ..|| |.|
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsg
0045450 (Phosphotyrosine protein) phosphatases II 19-147 6.7e-26 87.2 In-house 97-302 (307) alignment 
Range on Protein: 19-147
Range on HMM: 97-302/307.0
YLSGAGVLKPDK------------------IKQRKINMIVNATTEEPST----------------------------YMQGVDTMKIRIEDH--------
.| . |  ...|                  ... ....||. |.... .                            ...|.  ......|.        
lllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrt

---------PYARLSEHFDVVADKIRNVKE------RGGKTLVHCMAGVSRSASLVMIYLVKHEH--------MTLRQAYHYVKAARPIIRPNVGFWKQM
         |   ....|. . | |. |..      .||..||||.|||.|.......||... .        ..|..|...... || . .| ..... 
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

VDYEKR
 .... 
yealle
0040438 (Phosphotyrosine protein) phosphatases II 31-149 7.1e-26 86.6 In-house 106-276 (317) alignment 
Range on Protein: 31-149
Range on HMM: 106-276/317.0
IKQRKINMIVNATTEEPST---------------------------YMQGVDTMKIRIEDH----------------PYARLSEHFDVVADKIRNVKER-
... ....||. |..|.                             ...|.   ....||.                |   . ...| . | .. |.|  
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

---GGKTLVHCMAGVSRSASLVMIYLV-----KHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRLR
   ||..||||.|||.|.......||.     |...... .|.......|| . .. ...... |..  . 
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0040439 (Phosphotyrosine protein) phosphatases II 31-148 3.6e-25 84.4 In-house 74-245 (249) alignment 
Range on Protein: 31-148
Range on HMM: 74-245/249.0
IKQRKINMIVNATTEEPS-------------------------------------------TYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKE--
... .|..||..|....                                             . . .  . |.. | |   ....|. . | |. |..  
lwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkal

----RGGKTLVHCMAGVSRSASLVMIYLV-----KHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRL
    .||..||||.|||.|.. ....||.     |. ...| .|..... .|| . .| .....  .....|
eelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_LRR-DSP_pd Subfamily LRR-DSP 12-150 1.2e-24 80.8 In-house 121-260 (263) alignment 
Range on Protein: 12-150
Range on HMM: 121-260/263.0
SEINDHLYLSGAGVLKPD-KIKQRKINMIVNATTEEPSTYMQGVDTMKI-RIEDHPYARLSEHFDVVADKIRNVKERGGkTLVHCMAGVSRSASLVMIYL
.|| |.|.| |    .    .|.  .  |. | ..    . .    . |  ||| . | .| ||. .   | . ...||  |||| ||||||..||. ||
deiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisyl

VKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRLRG
.|........|.  |.  || |.|| || .|.  ||| |  
mkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 34-149 7.3e-24 77.5 In-house 27-142 (145) alignment 
Range on Protein: 34-149
Range on HMM: 27-142/145.0
RKINMIVNATTEEPSTYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQAYHYVKAARPIIRP
| .||    .    ... . .... |  ||     ||.||| |.| |   || |   .|||||||||| .. . .|.|.  ||| .|   |.. |    |
rivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllayp

NVGFWKQMVDYEKRLR
|| | |.... ||.|.
nvtflknllnlekqlk
0042113 (Phosphotyrosine protein) phosphatases II 14-147 3.7e-23 77.7 In-house 50-241 (245) alignment 
Range on Protein: 14-147
Range on HMM: 50-241/245.0
INDHLYLSGAGVLKPDK-----IKQRKINMIVNATTEE----------------------------------------------PSTYMQGVDTMKIRIE
|.........   .  .     ... .|..||. |.||                                               . . ...  . . ..
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

DHPYARLSEHFDVVADKIRNVKE--RGGKTLVHCMAGVSRSASLVMIYLV-----KHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKR
||. . |.|... . . .|.. .  ..|..||||.|||.|.. ....||.     |.  ..| .|.....  || .... ...... .... 
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 28-145 3.8e-23 77.2 In-house 26-150 (151) alignment 
Range on Protein: 28-145
Range on HMM: 26-150/151.0
PDKIKQRKINMIVNATTEEPSTYMQ------GVDTMKIRIEDHPYARLSEHFDVVADKIRNVKER-GGKTLVHCMAGVSRSASLVMIYLVKhEHMTLRQA
 . .|. .|..||| ..||.  |.       |.. . | |.|.|   |...|| |.. .. . .  .|..||||.||..|.. ||..||.. ....| .|
lellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleea

YHYVKAARP-IIRPNVGFWKQMVDYE
...... || ...|| .|..|. ...
leeyrlkrpgvvqpnqqflfqlfall
0039614 (Phosphotyrosine protein) phosphatases II 31-149 1.2e-22 76.2 In-house 121-289 (297) alignment 
Range on Protein: 31-149
Range on HMM: 121-289/297.0
IKQRKINMIVNATTEEPST-------------------YMQGVDTMKIRI-----------------------EDHPYARLSEHFDVVADKIRNVKE---
... ....||. |....                     .. .|.. .  .                        ||    ..|... . ...|.. .   
vweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelp

RGGKTLVHCMAGVSRSASLVMIYLV-----KHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRLR
.||..||||.|||.|.......||.     |. .... .|..... .|| .... .....  |... |.
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0036941 (Phosphotyrosine protein) phosphatases II 31-148 7.7e-22 73.4 In-house 98-276 (297) alignment 
Range on Protein: 31-148
Range on HMM: 98-276/297.0
IKQRKINMIVNATTEEPSTY-------------------------------MQGVDTMKIRIED----------------HPYARLSEHFDVVADKIRNV
. . ....||. |....                                   ... . .....|                 |   . |... . | |. |
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

KE------RGGKTLVHCMAGVSRSASLVMIYLV--------KHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRL
..      .||..||||.|||.||.......|.        |.. ... .|.....  || . ......... ...  |
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0038934 (Phosphotyrosine protein) phosphatases II 29-149 2.4e-21 71.7 In-house 50-177 (194) alignment 
Range on Protein: 29-149
Range on HMM: 50-177/194.0
DKIKQRKINMIVNATTEEPSTYMQ-----GVDTMKIRIEDH---PYARLSEHFDVVADKIRNvKERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQA
 | ...|. .... | .|.    .     |.. .|. ..|.   |   .  .|  ..|.. | .  ||. .|||.||..|.. ||  ||... .|....|
lkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefln.edpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeA

YHYVKAARPIIRPNVGFWKQMVDYEKRLR
..... .|| . ||........ . | ||
ialfrekRpgaipnqdyleallkrykelr
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 31-149 7.5e-21 68.1 In-house 24-153 (154) alignment 
Range on Protein: 31-149
Range on HMM: 24-153/154.0
IKQRKINMIVNATTEEPSTYMQG---------VDTMKIRIEDHPYARLSEHFDVVADKIRNVK--ERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQ
.....|. |.|  .  .  . .          .. ..... |..   . |..| . . |..     . .| |||. .||||||.|.. ||... ...| .
lqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislsl

AYHYVKAARPIIRPNVGFWKQMVDYEKRLR
|.  .| .|.||.|| || ||.  .||.|.
alellkdsryiikPnqGflkqleifekell
subfamily_STYXL1_pd Subfamily STYXL1 32-150 1.2e-20 67.3 In-house 34-155 (157) alignment 
Range on Protein: 32-150
Range on HMM: 34-155/157.0
KQRKINMIVNATTEEPSTYMQ---GVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQAYHYVKAAR
|  |.   || ...    .      .. ..|..||.. | | |... . . | . |..|   ||    |.||||.... ||. ....||..||.|.|  .
kdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCk

PIIRPNVGFWKQMVDYEKRLRG
. ..|| .| .|. ..||.| |
envkPnrafveqlseWekqllg
0051429 (Phosphotyrosine protein) phosphatases II 16-148 1.8e-19 65.9 In-house 22-224 (272) alignment 
Range on Protein: 16-148
Range on HMM: 22-224/272.0
DHLYLSGA----GVLKPDKIKQRKINMIVNATTEEP------STYMQGVDTMKIRIEDHPYARLSEHF--------------------------------
. ||.||.     .   ...|. .|..||. ..||       . | .|.. . . |.|. . . . ..                                
grlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------DVVADKIRNVKErGGKTLVHCMAGVSRSASLVMIYLVKhEHMT--------------LRQAYHYVKAARPIIRPNVGFWKQMVD
                . . . .. . . ||. ||||.||..|.. .|...|.  . ..              |..|.....|.|| .... .....  .
vmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye

YEKRL
... |
allel
0043336 (Phosphotyrosine protein) phosphatases II 31-145 1.3e-18 62.9 In-house 108-273 (278) alignment 
Range on Protein: 31-145
Range on HMM: 108-273/278.0
IKQRKINMIVNATTEE---------------------------------------------PSTYMQGVDTMKIRIEDHPYA-RLSEHFDVVADKIRNVK
... ....||. |...                                              . . ...    . . ||     || ..| . . .. ..
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

ERGGKTLVHCMAGVSRSASLVMIYLV-----KHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYE
 ..|..||||.|||.|.. ....||.     |. ...| .|.....  || . ..  ....  ...
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_STYX_pd Subfamily STYX 56-148 4.3e-18 58.9 In-house 65-157 (166) alignment 
Range on Protein: 56-148
Range on HMM: 65-157/166.0
TMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRL
 . . . | .   .  ..  | . | .  ..||| |||  ||.||||.||. |...   .  |.|..||.  |  | || || .|. .||   
ylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiy
subfamily_PTPMT1_pd Subfamily PTPMT1 50-148 3.1e-16 54.3 In-house 70-168 (171) alignment 
Range on Protein: 50-148
Range on HMM: 70-168/171.0
YMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMVDYEKRL
  .||. ..... |.  |   |.     . |..|...| .  ||| || .|||.||  ||.|.|.... .| ...|. |.||| .   ||..  ||. |
kklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
subfamily_MSG5_pd Subfamily MSG5 36-148 4.3e-16 52.5 In-house 48-160 (165) alignment 
Range on Protein: 36-148
Range on HMM: 48-160/165.0
INMIVNATTEEPSTYMQGVDTMKIRIEDHPYARLSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQAYHYVKAARPIIRPNV
.....| . | .   ..        || .  ...   .  ..  |   . .. | ||||  |.||||||.. |..|.  ..||.||. .|.    | |..
fdlvinvakeindlellvpavkyyhiewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsi

GFWKQMVDYEKRL
|.  |....|  |
glifqlmeweval
0047943 (Phosphotyrosine protein) phosphatases II 31-141 2.2e-14 49.0 In-house 97-264 (273) alignment 
Range on Protein: 31-141
Range on HMM: 97-264/273.0
IKQRKINMIVNATTEEPSTY------------------------------MQGVDTMKIRIED----------------HPYARLSEHFDVVADKIRNVK
... ....||  |...                                   ... . ......                 |     .... . . |. |.
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

E------RGGKTLVHCMAGVSRSASLVMIYLV-----KHEHMTLRQAYHYVKAARPIIRPNVGFWKQM
.      ..|...|||.|||.|........|.     |.  ... .|.....  || . ... .....
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 32-135 1.2e-12 43.4 In-house 113-272 (288) alignment 
Range on Protein: 32-135
Range on HMM: 113-272/288.0
KQRKINMIVNATTEEPS---------------------------TYMQGVDTMKIRIEDH--------------------PYARLSEHFDVVADKIRNVK
 . ....||  |...                             . .... . .......                    |     .... . | .| |.
weqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr

ER----GGKTLVHCMAGVSRSASLVMIYLV-----KHEHMTLRQAYHYVKAARPIIRPNV
.     || ..|||.|||.|.. .....|.     |...... .|.....  || . ...
kalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 32-134 2.4e-12 42.2 In-house 129-284 (308) alignment 
Range on Protein: 32-134
Range on HMM: 129-284/308.0
KQRKINMIVNATTEEPST----------------YMQG--------------VDTMKIRIED----------------HPYARLSEHFDVVADKIRNVKE
 . ....||  |...                   .. |              . . ......                 |     .... . | .. |..
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrk

R--GGKTLVHCMAGVSRSASLVMIYLV-----KHEHMTLRQAYHYVKAARPIIRPN
.  ||...|||.|||.|.. .....|.     |. .... .|.....  ||   ..
slpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
0046845 (Phosphotyrosine protein) phosphatases II 62-130 4e-11 38.3 In-house 176-255 (284) alignment 
Range on Protein: 62-130
Range on HMM: 176-255/284.0
EDHPYARLSEHFDVVADKIRNVKER---GGKTLVHCMAGVSRSASLVMIYLVKHE--------HMTLRQAYHYVKAARPI
 ||     .|..    ...|.. |.   ||...|||.|||.|.. .....|...         .... .|.....  || 
pdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg
0048567 (Phosphotyrosine protein) phosphatases II 73-142 5.9e-11 37.0 In-house 60-132 (157) alignment 
Range on Protein: 73-142
Range on HMM: 60-132/157.0
FDVVADKIRNVKERGGKTLVHCMAGV---SRSASLVMIYLVKHEHMTLRQAYHYVKAARPIIRPNVGFWKQMV
. .. .... ....|..  ||| ||    .|.| |.  ||..| ..| ..|..... .|| . |    .    
ilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasylls
subfamily_PTPDC1_pd Subfamily PTPDC1 52-129 2e-08 28.9 In-house 81-156 (182) alignment 
Range on Protein: 52-129
Range on HMM: 81-156/182.0
QGVDTMKIRIEDHPYARLSEHFDVVadKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQAYHYVKAARP
||.  ... ..|.  | | . .|.|  |. .   . ||. ||| ||  |   |.  ||| ....|  .| . |.. ||
qgiyvynfgwkDygvasleriLdiv..kvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
subfamily_DSP23_pd Subfamily DSP23 40-136 4.3e-08 27.9 In-house 36-133 (148) alignment 
Range on Protein: 40-136
Range on HMM: 36-133/148.0
VNATTE--EPSTYMQGVDTMKIRIEDHPYARlSEHFDVVADKIRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQAYHYVKAARPIIRPNVG
|  |.|   ..  . ..  ...||.|.      |  .     . . .|..    |||. |  |. ...  ||||.....  .|   |.  ||     | 
vslteegrphveatpnltlvrlriddyhppa.leqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetve
subfamily_RNGTT_pd Subfamily RNGTT 31-129 8.5e-08 26.1 In-house 50-155 (189) alignment 
Range on Protein: 31-129
Range on HMM: 50-155/189.0
IKQRKINMIVNATTEEPSTYM-----QGVDTMKIRIEDH---PYARLSEHFDVVADKIRNvKERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQAYH
 .. |. .... | ...         .|. ..|.... .   | |   ..|  . ..  . |.      |||  |  |.  |.. |||..|.. ...| .
tlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaava

YVKAARP
  . |||
lFakaRp
PTPc_DSPc_SM00012 79-114 1.2e-07 27.2 In-house 28-66 (105) alignment 
Range on Protein: 79-114
Range on HMM: 28-66/105.0
KIRNVK----ErGGKTLVHCMAGVSRSASLVMIYLVKHEH
.....|    . .. ..||| |||.|.. .|..... . .
avkknknkses.skpvvVhCsaGvgRtgtfvaldillqql
subfamily_CDC14_pd Subfamily CDC14 80-129 1.3e-07 25.8 In-house 256-305 (328) alignment 
Range on Protein: 80-129
Range on HMM: 256-305/328.0
IRNVKERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQAYHYVKAARP
.. ...  |.  ||| ||. |  .|.  ||.|| ..|  .|  ... .||
leiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP
subfamily_Laforin_pd Subfamily Laforin 82-131 2.2e-06 20.7 In-house 105-154 (183) alignment 
Range on Protein: 82-131
Range on HMM: 105-154/183.0
NVKERGGKTLVHCMAGVSRSASLVMIYLVKHEHMTLRQAYHYVKAARPII
 . |.| .  ||| ||| ||...|  .|    . .|..  ... | ||..
allekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
Y_phosphatase Protein-tyrosine phosphatase 71-111 6.4e-06 21.1 Pfam-A 150-194 (235) alignment 
Range on Protein: 71-111
Range on HMM: 150-194/235.0
EHFDVVADKIRNVKERG----GKTLVHCMAGVSRSASLVMIYLVK
|. . . | ||.|...     |...|||.|||.|....|.. .. 
espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
Y_phosphatase Protein-tyrosine phosphatase 71-111 6.4e-06 21.1 In-house 150-194 (235) alignment 
Range on Protein: 71-111
Range on HMM: 150-194/235.0
EHFDVVADKIRNVKERG----GKTLVHCMAGVSRSASLVMIYLVK
|. . . | ||.|...     |...|||.|||.|....|.. .. 
espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
subfamily_PRL_pd Subfamily PRL 31-128 9.3e-06 19.8 In-house 30-130 (151) alignment 
Range on Protein: 31-128
Range on HMM: 30-130/151.0
IKQRKINMIVNATteEPSTYMQGVDTMKIRIEDHPYAR--------LSEHFDVVADKIRnvkERGG-KTLVHCMAGVSRSASLVMIYLVKhEHMTLRQAY
.|..... .| .   ||.   . ...  |.. | ...         . | .... .| .   |...    |||.||. |.  || . |.  . |. ..| 
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