Gene C15H7.3 in Caenorhabditis elegans

Synonym: CELE_C15H7.3, CELE_C15H7.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP017_AA protein Get Run
CeleP017_AA_109-378 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 99-393 7.1e-120 394.0 In-house 2-301 (302) alignment 
Range on Protein: 99-393
Range on HMM: 2-301/302.0
KKEEVKEPWSEEEPAKRMVANgfFTTTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPD
|.|| ||.|.||| ||..|..  ..|..|  .||..|..|.....|..||.|..|....|.||....||||.. |.|...|.|..||...|..||.|.|.
kveeekekWveeeeakklvks..ldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpk

LSSAPDIADFWRMIHQESIASVVIAVMPLEV--TLQQILPLLSGTYSTYGKMFVNNKKVESAVGMT-EYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEV
..|......||||..||.|.||||.|.. |.  ||....|..||.|..||||||||.|||.|.... .|..|..|.|||||.|..||.|.||.||.... 
vdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvk

VTDLVATMEKV----MKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQRKVV
...|..|..||    .|...|||..|.||.||||..|||..|. ..|||||.|.||...|.|..|. .||...|. ..........|.. |..|...|..
yaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkkke

EF
|.
ev
0036941 (Phosphotyrosine protein) phosphatases II 129-391 3.7e-53 176.1 In-house 17-291 (297) alignment 
Range on Protein: 129-391
Range on HMM: 17-291/297.0
GTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPL
  |.. .... ... |. ....|..| | .|... .   |||.... ..|.|  ....|..|..|.|| |  .    ..|||||.... . ..|  . . 
kefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpn...tvedFWrmvweqnvtvIvmltelv

E---VTLQQILPLLSGTYSTYGKMFVNNKKVES--AVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLM
|   .. .|  ||  | . |||...|....||.    ..| . ||. . |...|.  |..| ..|      | ...|.. .|.| |       .  .. .
elgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVH

SMNGTGRAGTMLTLFTAMLQVQ---KGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQRKVV
...| ||.||........ |..   | ..|. .|.. .||  |.|.| . .|.  ... .....|.. | |.....|.
CsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl
0040438 (Phosphotyrosine protein) phosphatases II 107-392 5.1e-53 175.8 In-house 3-291 (317) alignment 
Range on Protein: 107-392
Range on HMM: 3-291/317.0
WSEEEPAKRMVANGFfttTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDlssA
.....  .......|   | .   |.. ...| .  |. ....|..| | ||... .   |||.. .     ..|.|  ...|...|..|.||.|     
ldlllalldllksdf...talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl...p

PDIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDL
  ..|||||.... . ..|  . . |      .|  ||  |.. |||...|.....|   |.| ..||. ..|.|.|.  |..| ..|      .  ..|
ntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdll

VATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQRKVVE
.. .|.| ..    .  .. ....| ||.||........ |..|...|...|... ||. |.|.| . .|.  ... .....|.. | |........
ldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklk
0050432 (Phosphotyrosine protein) phosphatases II 100-382 3e-51 170.0 In-house 19-304 (308) alignment 
Range on Protein: 100-382
Range on HMM: 19-304/308.0
KEEVKEPWSEEEPAKRMVAngFFTTTNVGGTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLtNGPESFICAAKITVP--DFNRTMILTQV
   .....| .. .|..     . ....   |..  ..|.... |. ....|..| | .|... .   ||| ... ..|.|  ....  ...|..|.|| 
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqg

PDLSsapDIADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSG-TYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRG
|  .    ..|||||.... .  .|    . |   ..  |  ||  | .. .|||..|.....|.  ..| . ||. . |...|.  |..| .||     
Plpn...tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgv

LEVVTDLVATMEKVMKV--NDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
 . ...|.. .|.| |.  . ..| ....| ||.||...| ... |..|...|.. |... ||  |.| | . .|.  ..| .....|.  |
PpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0047943 (Phosphotyrosine protein) phosphatases II 129-377 1.3e-48 161.2 In-house 16-272 (273) alignment 
Range on Protein: 129-377
Range on HMM: 16-272/273.0
GTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPL
  |..  ..|.... |. ....|..| | .|... .   |||..|. ..|.|  .......|..|.|| |  .   ...|||||.... .  .|  . . 
eefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpn...tvedfwrmvweqnvrviVmLtelv

E---VTLQQILPLLSGT-YSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLMS
|   ..  |  ||  |. . ||||..|.....|.  ..| . ||. . |...|.  |..| ..|      . ...|.  .|.|.|       |  .| ..
elgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHC

MNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
..| ||.||...|.... |..|...|...|... ||  |.|.| . .|.  ... .. ..
saGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 106-378 1e-46 155.1 In-house 4-287 (288) alignment 
Range on Protein: 106-378
Range on HMM: 4-287/288.0
PWSEEEPAKRMVANGFFTTTNVGGTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLTN----GPESFICAAKITVPDFNRTMILTQVPDLS
..| || .|.. .     .|..   |..  ....... |. ....|..| | .|..  .   |||..    .. ..|.|  |......|..|.|| |  .
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

sapDIADFWRMIHQESIASVVIAVMPLE---VTLQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPD----GCSNSLLTTVYHLHNWRQKRGL
    ..|||||.... .  .|.   . |   ..  |  ||  |.. |||...|.....|.  ..| . ||. .     |...|.  |..| .||      
...tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

EVVTDLVATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFK
. ...|.. ...|.|.    .  .| ....| ||.||...|.... |..|...|.. |... ||  |.|.| . .|.  |.. .. ..|
dspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
0043336 (Phosphotyrosine protein) phosphatases II 107-377 3.6e-46 153.3 In-house 2-277 (278) alignment 
Range on Protein: 107-377
Range on HMM: 2-277/278.0
WSEEEPAKRMVANGFFTTTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDLSsa
.| .. .|...  ..   | .   |.. ..||... |.  ...|..| | .|... . ..|||.. .     ..|.|  .......|..|.|| |  .  
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe..

pDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVAT
  ..|||||.... . ..|  . . |   ..  .  .|.. |||...|...|.|.  ..| . ||. . |...|.  |.|| ..|      | ...|.  
.tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

MEKVMK----VNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
...|..     |  .. ....| ||.||...|.... |..|...|.. |... ||  |.|.| . .|.  ... .....
lkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
DSPc_SM00195 144-377 6.4e-44 145.6 In-house 20-262 (263) alignment 
Range on Protein: 144-377
Range on HMM: 20-262/263.0
CPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLE---VTLQQILP
.  .|.|..| |  .... ... |||.. .    ...|.|  |.... ....|.|| |       ..|||||. .| .  .|. ... |    . ..  |
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekcdrywp

LLSGTYSTYGKMFVNNKKVESAV-GMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLF
  ||...|.||. |....||.    .. . ||.  .|....  .|.|. .|| ..   .  ..... ...| |     .  .| .. .| ||.||..|. 
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

TAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
... .....|.|. .|.. .|| .|.|.|.. .|. .... .. ..
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 144-377 6.4e-44 145.6 In-house 20-262 (263) alignment 
Range on Protein: 144-377
Range on HMM: 20-262/263.0
CPSFKNNMHKIRAPDCPIPEEKLVKLTNGP----ESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLE---VTLQQILP
.  .|.|..| |  .... ... |||.. .    ...|.|  |.... ....|.|| |       ..|||||. .| .  .|. ... |    . ..  |
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekcdrywp

LLSGTYSTYGKMFVNNKKVESAV-GMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKV----NDNTVLMSMNGTGRAGTMLTLF
  ||...|.||. |....||.    .. . ||.  .|....  .|.|. .|| ..   .  ..... ...| |     .  .| .. .| ||.||..|. 
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

TAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
... .....|.|. .|.. .|| .|.|.|.. .|. .... .. ..
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0039614 (Phosphotyrosine protein) phosphatases II 101-380 6.7e-44 145.9 In-house 10-292 (297) alignment 
Range on Protein: 101-380
Range on HMM: 10-292/297.0
EEVKEPWSEEEPAKRMvaNGFFTTTNVGGTFKQTDNFKTPmDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPE-----SFICAAKITVPDF-NRTMILT
| . .|.| .. ....  .  . .| .   |..  ..| .  |.  ...|..| | .|... .   |||.  ..     ..|.|  ....|. .|..|.|
esipiplsvldlllll..ekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QVPdLSSapDIADFWRMIHQESIASVVIAVMPLEVT--LQQILPLLSGtysTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSnsLLTTVYHLHNWRQKRG
| | |..   ..|||||.... . ..|    . |     .|  |  .|   |||...|...|||   |.| . ||. ..|.|  .  |... ..|     
qgP.lpe..tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgv

LEVVTDLVATMEKVMK------VNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNN
 . ...|   .|.|..       .  .. ....| ||.||........ |..|...|...|... ||  |.|.| . .|.  ... .. ..|..
ppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0045450 (Phosphotyrosine protein) phosphatases II 141-379 2.4e-43 144.4 In-house 46-306 (307) alignment 
Range on Protein: 141-379
Range on HMM: 46-306/307.0
MDSCPSFKNNMHKIRAPDCPIPEEKLVKLTN-----GPESFICAAKI--------TVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPL
  |. ....|..| | .|... .   |||..     .. ..| |  .         ..|..|..|.||.|  .    ..|||||.... .  .|    . 
eysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe...tvedFwrmlweqgvtvivmltelv

EVTLQ---QILPLLsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLMS
| . .   |  |.  |.. |||...|.....|   |.| ..||. .  |...|.  |..| ..|      . . .|.. .|.|.|       .  .. ..
elgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHC

MNGTGRAGTMLTLFTAMLQVQKGKE---VNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
. | ||.||........ |..|...   |.. |... ||. |.|.| | .|.  ... .. ....
saGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
0046845 (Phosphotyrosine protein) phosphatases II 143-382 5.5e-42 139.5 In-house 21-279 (284) alignment 
Range on Protein: 143-382
Range on HMM: 21-279/284.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLTN-----GPESFICAAKITVP-----DFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLEV---
|.  ...|..| | .|... .   |||..     .  ..| |  ....     ......|.|| |  .    ..|||||.... .  .|    . |    
svallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn...tvedFwrmvweqnvrvIVmltelvengre

TLQQILPLLsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDG-CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKV------NDNTVLMSMNGTG
   |  ||  |.. |||...|.....|   ..| . ||. . | ...|.  |..| ..|      . ..||.. ...| ..      .  .| ....| |
kcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg

RAGTMLTLFTAMLQVQKGK---EVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
|.||...| ... |..|..   .|.. |... ||  |.| | . .|.  |.. .. ..|.  |
RtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0040439 (Phosphotyrosine protein) phosphatases II 143-379 9.5e-42 138.7 In-house 4-248 (249) alignment 
Range on Protein: 143-379
Range on HMM: 4-248/249.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLTN----GPESFICAAKITVPDFNRTMILTQVPdLSSapDIADFWRMIHQESIASVVIAVMPLEV---TLQQIL
|. ....|..| | ||.....   |||.      . ..|.|  |......|..|.|| | |..   ..|||||.... | ..| .  . |    . .|. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgP.lpe..tvedfwrmlwelgitvivmLtslvelgrekcaqyw

PLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMK------VNDNTVLMSMNGTGRAGTMLT
||  |.. .||...|....||.  ..| . ||. . ....|.  .... ..|      . . ||.. .|.|.|       .  .. ....| ||.||...
pl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

LFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
..... |..| ..|...|... ||  |.|.| | .|.  ... .. ....
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
Y_phosphatase Protein-tyrosine phosphatase 150-373 2.3e-40 133.9 Pfam-A 1-233 (235) alignment 
Range on Protein: 150-373
Range on HMM: 1-233/235.0
NMHKIRAPDCPIPEEKLVKL--TNGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSGTYST
|..| | .|... ... |||  ..||. .| |  ..  . ....|.|| |  |.    .|||||. || . ..|. .   |   ....|  |  .... |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKMFVNNKkVESAV---GMTEYCLEIFPDGCSN-SLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQ
||...|..| ...     ..| . ||.  .. .. .  ....|..|| ..   | ...|. ...|| | .     ..| ....|.||.||...| ... |
ygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
.....||. .... .||..|.|.|....|.  ... .
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 150-373 2.3e-40 133.9 In-house 1-233 (235) alignment 
Range on Protein: 150-373
Range on HMM: 1-233/235.0
NMHKIRAPDCPIPEEKLVKL--TNGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSGTYST
|..| | .|... ... |||  ..||. .| |  ..  . ....|.|| |  |.    .|||||. || . ..|. .   |   ....|  |  .... |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKMFVNNKkVESAV---GMTEYCLEIFPDGCSN-SLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQ
||...|..| ...     ..| . ||.  .. .. .  ....|..|| ..   | ...|. ...|| | .     ..| ....|.||.||...| ... |
ygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
.....||. .... .||..|.|.|....|.  ... .
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0042113 (Phosphotyrosine protein) phosphatases II 143-378 7e-39 129.1 In-house 2-244 (245) alignment 
Range on Protein: 143-378
Range on HMM: 2-244/245.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPES----FICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLE---VTLQQIL
|. ....|..| | .|... .  .|||.. ...    .| |  ..........|.|| |  .   ...|||||.... | ..|    . |   |. .|  
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqyw

PLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLE---VVTDLVATMEKVMK--VNDNTVLMSMNGTGRAGTMLTL
||  |.. |||...|.....|.  ..| . ||. ..|.. |.  ..|| ..|      .    . |..  ..|...   |  .. ... | ||.||....
pl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

FTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFK
.... |..| ..|.. |... ||  |.|.| . .|.  ... .. ..|
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
0037934 (Phosphotyrosine protein) phosphatases II 143-377 1.8e-36 121.3 In-house 3-242 (243) alignment 
Range on Protein: 143-377
Range on HMM: 3-242/243.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLtNGpESFICAAKITVPDfnrTMILTQVPDLSSAPD-IADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGT
|......|..| | .|..  .   ||| .| ...|.|  |.|..   ..|.||.|  ..  |  |.||||.... | ..|    . | . ..  .. .|.
siallpenlsknrysdilpydhsrvkl.eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpge

YsTYGKMFVNNKKVESAVGMTEYCLEIFPDG-CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN------------TVLMSMNGTGRAGTML
. |||...|.....|.  ..| . |.. . .    ..| . || ..|      . ..||.. ...| .. ..            .... . | ||.||..
v.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

TLFTAMLQVqkgkEVNAKETLASLRAERCG-IVDNIDQFGTVHRSMACWF
.... .|..    .|.. |... ||. |.| .| . .|.  ... .....
aaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 183-370 1.1e-23 77.4 In-house 109-302 (346) alignment 
Range on Protein: 183-370
Range on HMM: 109-302/346.0
TVPDFNRTMILTQVPDLSSAPDIADFWRMIHQESIASVVIAVM--PLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTT
 . .|.. .|..|.|.. .   . ||| ||.|| |  | . |    |  |   ..    | |   ||||.||.. . .    || .|..|.| |.|..  
vifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicq

VYHLHNWRQKR----GLEVVTdLVATMEKVMKVN-DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVH
|.|   |.. .     | ..  ..  .    .|.     ..|. |.||| ...  . |. |.. | | |  | . ... .| | |. . |. ...
vhhhapwkhlqqppktlpiik.mihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiy
0045098 (Phosphotyrosine protein) phosphatases II 146-379 1.9e-22 75.4 In-house 29-274 (278) alignment 
Range on Protein: 146-379
Range on HMM: 29-274/278.0
SFKNNMHKIRAPDCPIPEEKLVKltngpeSFICAAKITVPdfNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVT---LQQILPllSGTY
 . .|..| | .| .  .   ||       .| |  |...  ....|.|| |       .||||||.... | ..| .   .| .     |  |  .| .
lylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgP...lpstvadfwrmlwelgitvivmltelvelgrekcaqywp..eggs

STYGKMFVNNKKVESAVGMTEYCLEIFPD----GCSNSLLTTVYHLHNWRQKRGLEVV-----TDLVATMEKVMK--------------VNDNTVLMSMN
 |||...|.....|    .|   |..           |.  |..|...|      .        .|.  .....|               .  ..   . 
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GTGRAGTMLTLFTAMLQVqkGKEVNAKETLASLRAERCG-IVDNIDQFGTVHRSMACWFKN
| ||.||.  ... . ..  .. |.. |... ||  |.| .| | .|.  ... .. ....
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Ptp69D_pd Subfamily Ptp69D 148-387 7.8e-18 59.6 In-house 46-296 (307) alignment 
Range on Protein: 148-387
Range on HMM: 46-296/307.0
KNNMHKIRAPDCPIPEEKLVKLTN--G--PESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLS-GTY
|.|  | | .|    ... |||..  |    ..| |  |   . ... |  | |       | |||||| . ..  .|.     | . ...    .  . 
kenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPv...eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiede

STYGKMFVNNKKVESAVGMTEYCLEIFPDG-CS----NSLLTTVYHLHNWRQKRGLEVVTDLVATMEKV---MKVNDNT-VLMSMNGTGRAGTMLTLFTA
  ||.. |.  . |..   ..  |..   . .|    .|   . ||  .|.     || . |.  .|.|    | |    |.   .|.||.|....|   
vqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsl

MLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNSTNEEVQ
. |... ..|.  ||   || .|  .|....|.  ..|... . .   |.|.|.
lqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvd
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 148-381 1.6e-17 58.5 In-house 45-283 (288) alignment 
Range on Protein: 148-381
Range on HMM: 45-283/288.0
KNNMHKIRAPDCPIPEEKLVKLTNGPE----SFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPL---EVTLQQILPLlSG
 .| .| | ..    .|| |||....|     .| |. | . . ... | || |  ..   . |||...... .  .|     .   . . ..  |  ..
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladt...vndfWelvyenktstivmltelveggktkCeeYWPd.ad

TYSTYGKMFVNNKKVESAVGMTEYCLEIFpdGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNT----VLMSMNGTGRAGTMLTLFTAMLQ
.   ||.. |  ....    ...  |..      . | .| |.   | ..   |  ..|.. ...|   |..     .   ..| ||.|| ..| ... .
kpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalida

VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNS
|.. . ..  .|.| || .|  .|..  |.  ... ..   ....
veeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 174-374 2.1e-17 58.3 In-house 84-287 (298) alignment 
Range on Protein: 174-374
Range on HMM: 84-287/298.0
ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPllSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFP
  .| |. .   . . . |.|| |  ..   ..|||||. .| |...|.     |.   . ..  |  .    |||.. |. .. |.   ..   |..  
sdYiNAsflhaykgrnafiatqaPltet...vedFWrmvteedigtiVmltnleeldktkyhkywP..degketygeitvsllskeefadlivrklkvsk

DGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN----T-VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQ
   ...      |  .| .|   |. | ... ..|| . . .      ..   .|.||.||   . . . .|.| . |   ...  ||..|.|.|.  .|
kkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeq

FGTVHRSMA
.  ..  . 
Yvfiyeavl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 176-372 2.2e-17 58.1 In-house 39-237 (250) alignment 
Range on Protein: 176-372
Range on HMM: 39-237/250.0
FICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAV--MPLEVTLQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGC
.| |. . . | ... | || |  ..   | |||||. .| ....|.       | | .| .|    .  .||.. |. .. |    .|   | .     
yinasflhgyderkafiatqgPlqat...iedfWrmvleeksgtivmLtnLkesektyhqywPv..ekaekyGdvtvsllskeefadytkrklklskakk

SNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGT
... .   .|  .|  |   || |  .. ..|| . ...      ..   .|.||.|. ... . . ...| | |.  . .  ||..| . |.  .|.  
aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvf

VHRS
|.. 
vyei
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 176-388 1.1e-16 55.8 In-house 78-294 (319) alignment 
Range on Protein: 176-388
Range on HMM: 78-294/319.0
FICAAKITVPDFNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIA---VMPLEVTLQQILPllSGTYSTYGKMFV--NNKKVESAVGMTEYCLEIFP
.| |. |   . ..  | || |    .  | |||||. .| .  ||.    | .|.| |... |  . .. .||.. |  ....  . . . . .|..  
yinasfidgyqerekfiatqaP...lentiedfWrmvWeeessivvmltklveklkvklkkywp..eenfeeyGrlivtleeeeeledyiirklklnkks

DGCSNsLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQ
.        . ..  .| ..   |  | |.. .... |  ..      |    .| || || ..|. .. .|..   ..  .|   ||. |  .|.. .|
sevet.RevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeq

FGTVHRSMACWFKNNSTNEEVQR
.  ..  .  . .  .|. ||| 
Ykfiyealleaveagdteievqd
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 168-373 9.1e-16 52.9 In-house 64-279 (305) alignment 
Range on Protein: 168-373
Range on HMM: 64-279/305.0
KLT----NGPESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVM---PLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVG
.||    .. . .| |. .   . . . |..| | | .   .|||||.| .| . ..|. .      .   .|  |   .    .|.. |. |  ..| .
iltekeslddsdyinasyvdgykrkkkyivaqgP.lknt..vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasd

MTEYCLEIFP-DGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNT-----VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRA
 .|  |.|   |. ..|   . |.| .| ..   .  | |.  ...|.|   .      .    .| ||.|. ...  |. ...| ..|.  | |  || 
yieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRs

ERCGIVDNIDQFGTVHRSM
.| ..| . ||.  .|  .
krmkmvqtldqYvflhdal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 171-378 3.6e-15 50.9 In-house 75-285 (297) alignment 
Range on Protein: 171-378
Range on HMM: 75-285/297.0
NGPES-FICAAKitVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIF
. |.| .. |.   |. ..  .| || |  ..   .||||.|. .| .. .|.     | . .        . .|.|.. |  . |..  |. .  ||. 
ddpdsDyvnasf..vkgnkhrlittqmPmkat...vadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevt

PDGCSNSLLTTVYHLHNWRQKR-----GLEVVTDLVATMEKVMKVNDN--TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDN
 .   .  .   |.  .| .|        . . .|.  ..|. . | .   ..  ..| ||.| .||.   . .... |||.  ...  || ||  .|  
kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqt

IDQFGTVHRSMACWFK
 .|.  |.  .   . 
keqykfvyvavleall
PTPc_DSPc_SM00012 280-373 3.9e-15 51.3 In-house 3-103 (105) alignment 
Range on Protein: 280-373
Range on HMM: 3-103/105.0
TVYHLHNWRQKRGLEVVTDLVATMEKVMKVND------NTVLMSMNGTGRAGTMLTLFTAMLQVQKG-KEVNAKETLASLRAERCGIVDNIDQFGTVHRS
..|| ..| ..   | ..... ....|.|..       ..|... .| ||.||. .| ... |..|. |||. .... .|| .| | |.. .|.  ..| 
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

M
.
l
subfamily_PTPN12_pd Subfamily PTPN12 168-382 6.7e-15 49.7 In-house 61-282 (290) alignment 
Range on Protein: 168-382
Range on HMM: 61-282/290.0
KLTNG-PESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTL---QQILPLLSGTYSTYGKMFVNNKKVESAV-GMT
| ..   ...| |  |  .. . . | .| | |. .  . |||||| . ..  ||.| . .|.     ..  |   ..  ..|.. |.... .    ...
kieeeegsdYinanfikgvegkleyiaaqgP.Lpkt..lddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddfl

EYCLEIFPDGCSNSLltTVYHLHNWRQK---RGLEVVTDLVATMEKVMKVNDNTVLM-SMNGTGRAGTMLTLFT--AMLQVQKG-KEVNAKETLASLRAE
  .|..  .. |...  . .| ..|  .   .. . . .|....... . .|. ...    | ||.||....     .|. .|  .|..  . ...|| .
irtLkveaqkesrkv..yqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkq

RCGIVDNIDQFGTVHRSMACWFKNNST
|  .|   .|.  |....|  .... .
raalvqtkeqyelvykavaelvqkele
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 167-370 1e-14 49.2 In-house 61-270 (315) alignment 
Range on Protein: 167-370
Range on HMM: 61-270/315.0
VKL---TNGPE-SFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLE---VTLQQILPLLSGTYSTYGKMFVNNKKVESAV
|||    . |.  .| |..|   | ... | .| |  .|   . |||||. || ....|.     |   .  .|  |   .    .|.. |.  ..|.  
vkleviddsPdsdyinasyiksvdddkayiasqgPlkas...vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadt

GMTEYCLeIFPDGcSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN---DNT-VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAE
...   | .  ..  .|   | .....| .|   . .. |.  . .|   |   . . ..  . |.||.| ....   . |..... |.  ...  |||.
dgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrak

RCGIVDNIDQFGTVH
|  .|   ...  ..
rpylvqteeeyafiy
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 175-379 1.4e-14 48.9 In-house 58-270 (274) alignment 
Range on Protein: 175-379
Range on HMM: 58-270/274.0
SFICAAKITVPDFN-RTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTL---QQILPLLSGT--YSTYGKMFVNNKKVesaVGMTEYCLEI
|.| |  |  .| . .. . || | |...  .|||||||.||..  .|.     |      ..  |   ..    .||.. ....|.   |   .| .. 
syinanyikGydeeskayvatqGP.lpnt..vadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikveki...verndysvrk

FPD-GCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-------TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIV
.    ....   . |   .|  ..  . .. |. ....| . ...       .|.    | ||.|  ..   |. |... . |.  .. . || .| |.|
lvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmv

DNIDQFGTVHRSMACWFKN
.. .|.  .|| .. . |.
qtseqyelihralclylkr
subfamily_PTPRD_pd Subfamily PTPRD 191-382 1.5e-14 48.6 In-house 93-286 (564) alignment 
Range on Protein: 191-382
Range on HMM: 93-286/564.0
MILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLLsGtYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNW
 | || |    |. |.|||||. .. ....|.     | .   ...  |   |   |||.. |. .. |    ..   ...     |.|   . .|  .|
yIAtqgP...laetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsW

RQKRGLEVVTDLVATMEKVMKVNDN----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
 ..   |  |.|.. ..|| ..| .    .|    .| || || ...   . .... | |.  .... ||..|  .|.. .|.  .|. ..   .  .|
PdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 176-383 2e-14 48.5 In-house 78-294 (325) alignment 
Range on Protein: 176-383
Range on HMM: 78-294/325.0
FICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESiASVVIAVMPLEVTL---QQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDG
.| |. .       ... .|.|  ..   | |.||.. .   .|||. .  |.       .  |   |   |.| . |. . .|         |..    
yinasylrddkkkdvflaaqaPltat...indlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk

CSNSLLTTVYHLHNWR----QKR--GLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDN
  ...    ..|  |     |||   |  ...|| .... .. |       ..  ..| ||.|....|..|. .| .  .|.  . .  ||..|  .|. 
kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvet

IDQFGTVHRSMACWFKNNSTN
.||.  .. ...  . .  |.
vdqyiliyealveaymsgntd
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 146-374 3e-14 47.7 In-house 50-276 (315) alignment 
Range on Protein: 146-374
Range on HMM: 50-276/315.0
SFKNNMHKIRAPDCPIPEEKLVKLTNGpESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTY
  ||  ..| | |   ..  |..  ..   .. |. |   . .|  | .| |  .|   . ||||....| |. .|.     |   ..          .|
kqknryiniiaydksrvqlpllendph.sdyvnanfidGynkkrryiaaqgpnvas...vkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviy

GKMFVNNKKVESavgMTEYCLEIFpDGCSNSLLTTVYHLH--NWRQKRGLEVVTDLVATMEKVMKVNDNTV----LMSMNGTGRAGTMLTLFTAMLQVQK
||. |  |. |     |||.   .    ... . .|. ||   | .    .  . |.  . .|.. ..|.|    .   .| ||.||..|| . . |.. 
Gkitvtrkseev...nteytvrtl.svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaea

GKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMA
 . ..  . .  .|. | ..|. ..|.  ..  . 
enaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 138-373 3.4e-14 47.5 In-house 31-267 (288) alignment 
Range on Protein: 138-373
Range on HMM: 31-267/288.0
KTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLEVTLQQ---I
....|.  || .|  . |  . |  .   |||.. |. .| |  ..   ..| .| .| |       |  .|.|. .. .  .|.    ||  ...    
easidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPl...ngtieelWkmllesdveyivmlcellekGkeksaey

LPLLSGTYSTYGKMFVNNKKVESAVGMT-E-YCLEIFPDGcSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFT
.|.  |    .|..    ||  . .  . .   | |   |  .. .  . ||..| ..   |     .  .| . ...   |..| .|.||.||.   . 
fPsklGekarigrlctvvkkkradidklvkvsllriskeg.eekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlilili

AMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
|. ...    .  .. ||.||.||   .    |.  ||| .
aleslrlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_PTPN23_pd Subfamily PTPN23 133-371 3.6e-14 47.3 In-house 26-274 (288) alignment 
Range on Protein: 133-371
Range on HMM: 26-274/288.0
QTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKIT-VPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTL
|... ..   |.   | . .| |  |.   ... ||| .. . .| |. .  .     ..| || |  |.   ..|||.|....    .|. . . |   
qkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqst...lnDFWlmvyeqkssviVmllskeelgk

Q---QILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKrGLEV-VTDLVATMEKVMK--------VNDNTVLMSMN
.   .  |   |   ..|.. |  |.|...  . |. |..   . ..    .  .|..| .  |.     .|.. ...| .        ..   |.    
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpel.GvPasPetllqfldevesayeavqrksktPlvvhCsa

GTGRAGTMLTLFTAMLQVQKGKEV-NAKETLASLRAERCGIVDNIDQFGTVHR
| ||.|..  ...|. ...||. . .  . .  ||..|   | . .|.  .  
GvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsye
0041856 (Phosphotyrosine protein) phosphatases II 150-382 4.2e-14 48.0 In-house 1-176 (182) alignment 
Range on Protein: 150-382
Range on HMM: 1-176/182.0
NMHKIRAPDCPIPEEKLvkltngPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVmplevtL----Qqilpllsgtysty
|..| | .| . ..  .      . ..| |  .  .  ....|.||.| ||   ..|||.||.... | ..| .                          
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls...tvadflrmlkelgittivnlt......eelywp.............

gkmfvnnkkvesavgmteycleifpdgcsN--SLLTTVYHLHNWRQKRGLEvVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQvqkgkEV
                             .    | . |. ..|      . . .|.. .|.| . . ...   . | ||.||.  ..  . .     .|
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

NAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNST
.. |... .|  |.|.| . .|.  ... . ...... |
sleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_PTPRK_pd Subfamily PTPRK 148-372 4.5e-14 47.0 In-house 41-272 (314) alignment 
Range on Protein: 148-372
Range on HMM: 41-272/314.0
KNNMHKIRAPDCPIPEEKLVKLTN--GP--ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYS
..| .| |  |   ..  .|.|.   |     .| || |      .  | || |  .    ..||||....|  ||.|.     ||.  . |       .
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqet...vkdfWrlvydencasivmltelvevgrvkClkyWPedte

TYGKMFVNNKKVESAVGMTE--YCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVND----NTVLMSMNGTGRAGTMLTLFTAMLQV
.||.. |.  ..|    .    . .|    | ..  .   ..  .| .       | |.. . .| | ..    ..|.  ..|.||.|| ... . .  .
vygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmi

QKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
.. . |.  ..  .||...  .|.  .|.  ..  
eregvvdvfnavktlrsrkvnmveteeqykfiydv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 141-379 5.1e-14 47.0 In-house 42-282 (318) alignment 
Range on Protein: 141-379
Range on HMM: 42-282/318.0
MDSCPSFKNNMHKIRAPDCPipEEKLVKLTNGPES-FICAAKITVPDFNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLS
....  .||    | | |      || .|.. ..| .| |  |     ... | .| |    .  | |||||. .   | .|.     | . ...     
lepvnkaknryanilaydht..rvkLqmlegeegsDyinanyidGyrrkkayiaaqaP...lpetieDfWrmvWeqnsavivmltqeeergkakvhryWP

-GTYSTYGKMFVNNKKvesAVGMTEYCLE---IFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN-----DNTVLMSMNGTGRAGTMLTL
     .|||. |. |.    | ...| |    .  .....|     ||  .| ..  .| ...|.. . .| |..     . .|     | ||.|. ...
skgsrsygklvvelke...evelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiav

FTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
 . . .... . |.  .|   || .|  .|   ||.  ..  .    . 
dillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_PTPRA_pd Subfamily PTPRA 191-384 6.7e-14 46.5 In-house 103-302 (330) alignment 
Range on Protein: 191-384
Range on HMM: 103-302/330.0
MILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLE---VTLQQILPllSGTYSTYGKMFVNNKKVE--SAVGMTEYCLEIFPDGC--SNSLLTTVYH
 | .| |   .   . |||||| .   |..|.     |      .|  |  .    |||.. |. ....   .. . .....  ||..   .| | . .|
fiaaqGPkeet...vedfwrmiweqksativmltelkerkeekcaqywP..deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfh

LHNWRQKrGLEV----VTDLVATMEKVMKVNDNT-VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFK
.. | .  |. .    . .|.. ..|. ... .. |.    |.||.||...| . . .|.  . |.  |.. .||. |. .|    |.  ... .  .. 
ftswPdv.GvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl

NNSTNE
   |. 
ygdtel
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 129-381 8.5e-14 45.9 In-house 26-283 (303) alignment 
Range on Protein: 129-381
Range on HMM: 26-283/303.0
GTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTNgpESFICAAKITVpDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLE
  |..  ..  |  |   | .||.| |  |    .   |||..   |.| |. . . | ..  ||||.|   .|   ||||.|| .. .  |.. .   |
nefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd..ssyihasylel.dsskkailtqlplshta...adfwqmiieqkvkcvlllltdse

VT---LQQILPLlSGTYSTYGKMFVNN---KKVESAVGMTEYCLEIfPDGCSNSLLtTVYHLHNWRQKRGL-----EVVTDLVATMEKVMKVN--DNTVL
      . ..|     .  . . ..     |.|| . | .   | .  .|  .|.|  |.| ..| ..        ..| ..      . |      || 
ydklggdsvfpr.nqdflkfeersirvgefkrvelgdgwvlkvlsv.sngdyksfl.hvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvy

MSMNGTGRAGTMLTLFTAMLQVQKG-KEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNS
||. | |||||.  . || | ...    ..    |  .|  |   |.|. ||  |.  .|    .| 
mslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldng
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 146-376 2e-13 45.0 In-house 31-258 (267) alignment 
Range on Protein: 146-376
Range on HMM: 31-258/267.0
SFKNNMHKIRApDCPIpEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTY
.  ......    .|  ... | | .  | .| |. .     ....|.|| | |. .  |.||. .||.. .. .|.  .  .  .... |   |    |
eknqernrldd.nlpy.ddtrvilrtkeeeyinasyvegyktknafivtqdp.lknt..itdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakky

GKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLlTTVYHLHNWR----QKRGLEVVTDLVATmEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGK
  . |.    .         ||.     |     |.|. ..|     .|  |. .  ..|  ... . |   |.   .| ||.||.|.. . . ....  
qdltvehslekeendyqiitlelkfknesahn.vtlyyykkwnintnnkpylkplfgilak.nqlengnrPlvvacsdGvGrsGtflvidsqlerakteg

EVNAKETLASLRAERCGIVDNIDQFGTVHRSMACW
 ..  . |  .|  | |.||  ...  .|...| .
vsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_CG7180_pd Subfamily CG7180 132-373 2.8e-13 44.2 In-house 24-286 (296) alignment 
Range on Protein: 132-373
Range on HMM: 24-286/296.0
KQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLT--NGP--ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPL
|.| ....    .   |.|. | | ...  .. . | |.  .|   . .| |. .     ..  | |. |  ..   . .|||....| | .||.   . 
kltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkket...vdefWrlvydeeisavvvLtktf

EVTL--QQILPLLSgtYSTYGKMFVNNKKVESAVGMTEYCLEIFPD----------GCSNSLLTTVYHLHNWRQKRGLEVV-TDLVATMEKVMKVNDNT-
. .   .. .|  |     ||..||.  ....   .. . . .                .  . ....|  |  .  . .. . |.  ...| .. ... 
dfakmypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd

--------VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
        | .| .|..|.|  |..  .. .|.| .||.  | .  || .| ..|.|....  .   .
edpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 167-370 3.4e-13 43.5 In-house 60-269 (515) alignment 
Range on Protein: 167-370
Range on HMM: 60-269/515.0
VKL---TNGPES-FICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLLSGTYSTYGKMFVNNKKVESAV
|||    . |.| .. |..|   | ... | .| |  .|   . ||||.. || .. ...     |       .  |   |    .|.. |.   .|.  
vklevindnPhsdyfnasyipsfdndkayiasqgPnkas...vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleact

GMTEYCLEIFPDgcSNSLLTTVYHLHNWRQKrGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRA
|..   |..  .  ..|   | .|...| .| | .  |  .  . | .| . .      ..  . | ||.| ....   . ...... |.  ...  .|.
ggikrkltvlkg..ddsrtvtqfhfteWPdk.GvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirq

ERCGIVDNIDQFGTVH
.|  .|   .|.  ..
krpylvqtqeqyafiy
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 176-374 5.7e-13 44.0 In-house 55-252 (284) alignment 
Range on Protein: 176-374
Range on HMM: 55-252/284.0
FICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVmplEVTLQQILPLLsgTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSN
.| |. ||    .   | || |       .||||||| .  ....|.     .    |  ||   .  ..... |. . || .  ..   .|.  ||  .
yinasfitGyqrkdkyiatqGPl...dntladfWrmiweyncstivllt...kdkcsqywplk..ivikeerfkvkvdsveeseeyvvrdielsedgkek

SL-LTTVYHLHNWRQKRGLEVVTDLVATMEKV------MKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGT
     . .|.  | ..   .  .||.. ..||      .. . | |.    |.||.|....| . . .... | |.  ...  || .|  .|... |.  
dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf

VHRSMA
.. .. 
iysall
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 144-372 1e-12 42.5 In-house 27-261 (283) alignment 
Range on Protein: 144-372
Range on HMM: 27-261/283.0
CPSFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVP---DFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVM---PLEVTLQQILPL
. | ..| .| |  .    . . |.| . ....| |. |.|    . ..  | .| | |  .  . |||.|...| |...|.       |..   |  | 
iasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsP.ldrt..vvdfWkmvfdekitaivmltklqedlrikCsqyWPk

lSGTySTYGKMFVNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTVYHLHNWRQKRGLEVVTDLVAtMEKVM----KV-NDNTVLMSMNGTGRAGTMLTLF
  |.   ||.. |  .|  .   ..   | .  .  . ..|| . | . .| .     ..  ||  ..||.    .  .   |.   .| ||....... 
.rGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvislqteskkgPivvhCstgiGrtavfiaas

TAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
... ...    |.  ...  .| .| ..| . ||.  ||  
asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhel
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 176-373 1.3e-12 42.7 In-house 91-287 (319) alignment 
Range on Protein: 176-373
Range on HMM: 91-287/319.0
FICAAKITVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVmplEVTLQQILPLLsgTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSN
.| |. .|    .   | .| |       .||||||| .  ....|.     .    |  ||   .  ..... |. . || .   .   .|.  ||  .
yinasfvtGyqrkdkyiaaqGPl...dntladfWrmiweyncstivllt...kdkcsqywplk..ivikeerfkvkvdsveetaeyvvrdielsedgkek

SL-LTTVYHLHNWRQKRGLEVVTDLVATMEKV------MKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGT
     | .|.  | ..   .  .||.  ..||      .. . | |.    |.||.|. ..| . . .... | |.  ...  || .|  .|... |.  
dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf

VHRSM
.. ..
iysal
0046846 (Phosphotyrosine protein) phosphatases II 200-379 2.6e-12 42.3 In-house 22-175 (176) alignment 
Range on Protein: 200-379
Range on HMM: 22-175/176.0
SSAP---------DIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGtYSTY-GkmfvnnkkvesavgmteycleifpdgcsnsllttVYHLHNWR-
.|.|         ..|||..|.... |  ||    . |    ..  . .  . ..                                     |. ..|. 
gsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi..................................qylhlpwpD

-QKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFtamlQVQKGKEVNAKETLASLRAERC-GIVDNIDQFGTVHRSMACWFKN
 .   || . .|.. .... | . ...   . | ||.||.. ..     ....| ... |.|| .|. |. |.| . .|   ... .  ..|.
hgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellllkk
subfamily_PTPN13_pd Subfamily PTPN13 131-371 4.3e-12 40.9 In-house 17-263 (273) alignment 
Range on Protein: 131-371
Range on HMM: 17-263/273.0
FKQTDNFKtPMDSCPSFKN--NMHKIRAPDCPIPEEKLVKLTNGPEsFICAAKIT--VPDFNRTMILTQVPdLSSApdIADFWRMIHQESIAsvVIAVMP
||.  ..| |.|.| . |.  |..| |  .    .|  ||| .    .| |. |   | . . ..|..| | |  .  ..|||.|. . .    |||.. 
fkelrelk.pldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGP.lPet..vkdfwqmvweqkae..viamvt

LE-----VTLQQILPLLSG-TYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVND---NTVLMS
||     |  ..  |   . .   .... |.. ||.   |..   |..     ..|   .  .. .|         ..|.  . .| ....     |   
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhc

MNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHR
  | ||.||..|. ...  ... ||.. ||.. .||  | |.|   ||.  |..
saGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 149-375 1e-11 39.3 In-house 46-276 (287) alignment 
Range on Protein: 149-375
Range on HMM: 46-276/287.0
NNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTY-STYGK
.| .| |  .  .|... | | .  . .| |. |     ..  |... |  . |    .||..|... .  .|. .   | . ..     . .   ..|.
qnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfnta...rnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGe

MFVNNKKVESAVGMTEYCLEIFPDG-CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVND-----NTVLMSMNGTGRAGTMLTLFTAMLQVQKGK
  ..  . |   |..|  ||.  ..  .. .  . |.. || ... ..     .  .|. .| .        |    .. ||.....   |.. ....  
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteG

EVNAKETLASLRAERCGIVDNIDQFGTVHRSMAC
 ..  . | | |  . | |  ..|.  .   .  
viDvfqvlksqriqkpgsvqtveqykfindivle
subfamily_PTPRG_pd Subfamily PTPRG 187-383 1.5e-11 38.2 In-house 89-293 (563) alignment 
Range on Protein: 187-383
Range on HMM: 89-293/563.0
FNRTMILTQVPDLSSapdIADFWRMIHQESIASVViAVMPLEVT----LQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFP------DGCSNS
 ..  | || |  .    . |||||| ..  | .|  .  |.       ..  |    .  |||.. |. .. |  .  |.  | |        . | . 
kskafiatqgplkdt...fddFWrmiWeqnvaiiv.mitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdte

LLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDN----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
.| . ||  .| ..   |  .  .  ..|  . | .    .|    .|.||.|| . | | . |.|. . ||  ..|  .||.|  .| ...|.  .|  
klvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhda

MACWFKNNSTN
.  . . . |.
lleaiaskete
0051429 (Phosphotyrosine protein) phosphatases II 199-379 2.5e-11 39.3 In-house 26-227 (272) alignment 
Range on Protein: 199-379
Range on HMM: 26-227/272.0
LSSAP---DIADFWRMiHQESIASVVIAVMPLEVTLQQILPLLS-------------GTYSTYGKMFVNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTV
.|..|   ..|||||. ... | ..|    . |.  ..  ...               .  .||...| . ..|    .. . |..    . ....  ..
rsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmh

YHLHNWRQKRGL-EVVTDLVATMEKvmkvNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVN--------AKETLASLRAERCGIVDNIDQFGTVHRS
.| ..|       | . .|.. . .    . . .   . | .| ||.  |.  .|.| .   |.        . |... ||| | |.| . .|.  ... 
lhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea

MACWFKN
.. ....
llellrs
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 151-372 2.8e-11 37.8 In-house 47-278 (290) alignment 
Range on Protein: 151-372
Range on HMM: 47-278/290.0
MHKIRAPDCPIPEEKLVKLT------NGPESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPL---EVTLQQILPLLsGT
 .. |  .. ..... . |       . ....| |. |     ..  |.|| |  .    ..|||..| ||... .|. .      .|. ||  |   .|
kllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsnt...lvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dt

YStYGKMFVNNKKVESAVGMTEYCLEIFPDGC-SNSLLTTVYHLHNWRQKRGLEVVT---DLVATMEKVMK--VNDNTVLMSMNGTGRAGTMLTLFTAML
 . ||.. ..  . |.  ...|  ||.  .    ..   | |.. || ..  ..  .    ... |.| ..   |   |.   .. ||... ... |.. 
ka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattin

QVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRS
....   ..  . | |.|  . | |   .|. .... 
kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqi
subfamily_PTPN3_pd Subfamily PTPN3 148-371 9.4e-11 36.1 In-house 39-269 (280) alignment 
Range on Protein: 148-371
Range on HMM: 39-269/280.0
KNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKIT--VPD--FNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLlSG
 .|..| |  |    ..  |||....  .| |  .   .|   .    | || |  ..    .|||.|......  .|.    .|       |  |  ..
penlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlakt...atdfWqmvweqksslivmlttlverGrvkChqyWPe.te

TYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQ
  ..||.. |. .| ..   .    | .     ...   .     .| ..   .  .|..  .|.| |.     . .|.    | ||.| ...| ||.  
deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalal

VQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHR
... ..|.  . .  .|  |  .|.. .|.  |  
ieaaepvypldivrtmrdqramlvqtasqykfvCe
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 150-361 1.4e-10 35.3 In-house 54-267 (290) alignment 
Range on Protein: 150-361
Range on HMM: 54-267/290.0
N--MHKIRAPDCPIPEEKLVKLTNGPES-FICAAKitVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLLSGTYS
|  ..| |  | .  .   | | .| .  .. |    |   . ..|||| .    .  . |.|||. || .| .|.    .|      .|  |  .|   
ntefkknrykdvvcndktrvilkdGydGdyvhany..vkGlkamfiltqGal...kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl

TYGKMFVNNKKV-ESAVGMTEYCLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKE
|.|.. |   .  .    .    | .       .     ...  | .|        |. |.  . |..   |.    | ||.||. .. ...  . .|||
tfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGke

VNAKETLASLRAERCGIVD
..  ..  .||  | . |.
ldlldlvralrnsrlnsvq
subfamily_PTPRB_pd Subfamily PTPRB 165-381 1.5e-10 35.6 In-house 69-289 (293) alignment 
Range on Protein: 165-381
Range on HMM: 69-289/293.0
KLVKLTNGPE-SFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLLSgTYSTYGKMFVNNKKVESAVG
|| .|.. ..  .| |  |     .|  | || | | ..  . |||||....    .|.    .|      ..  |  . .  .||.. |. .. |.   
kLaalkdesgsDYinanyipgynsprefiatqGP.lpet..vddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeled

MTEYCLEIFPdgCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN------DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRA
 .   |.|     ...  .. ||   | .    |  . |.. ...| ..         .|     | ||.|| ..| . . ....   |.   ..|.|| 
wvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelRe

ERCGIVDNIDQFGTVHRSMACWFKNNS
||. .| . .|.  .|...   .....
eRnllvqtekqYifihqcvldllrkke
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 142-378 2.7e-10 34.8 In-house 33-278 (307) alignment 
Range on Protein: 142-378
Range on HMM: 33-278/307.0
DSCPSFKNNMHKIRAPDCPIPEEK-LVKLTNGP-ESFICAAKITVPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLE---VTLQQILP
 .  .|. | .| |  | .  .   .|  ..|    .| |  . .    . .| .| |  ..   . .|| |. || . ||.. .  .|   .  .|  |
vtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplent...qysfwamaiqekvesvimlckvielakikceqywp

LLSGTYSTYGK----MFVNNKKVESaVGMTEYCLEIFP---DGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVmKVNDNTVLM-SMNGTGRAGTML
|  |   ..|.    . |.|  ..  .   | ....     | ...|   . .  .|| ..   ..    .  .| | . . | |..    | ||.||..
leegqklvfgeapntisvanlgakk.lapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav.rydtnpvvvhcsaGvGrsGtiv

TLFTAMLQVQKGKEVNA-KETLASLRAERCGIVDNIDQFGTVHRSMACWFK
..   . .. .|..  . |. .  ||..|   . .  |.  .|| .  .| 
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 184-373 7.1e-10 33.4 In-house 79-272 (281) alignment 
Range on Protein: 184-373
Range on HMM: 79-272/281.0
VPDFNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVT---LQQILPlLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTT
  . ..  | || |  .|   ...||.|. ....  .|.    .|       .  |    .  .||.. |.... |.   . |  ...  ... .  .. 
gykgekeyiatqgPvPas...lvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveq

VyHLHNWRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQV-QKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
. .  .| ..   .  ..|.   ..|.|....      |.    | ||.|| ..| ... .| .. .|.. |...|.|| ||  .|  . |.  |.. .
l.aytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 204-379 7.1e-10 33.3 In-house 76-266 (270) alignment 
Range on Protein: 204-379
Range on HMM: 76-266/270.0
DIADFWRMIHQESIASVVIAVMPLEVTLQQ---ILPLLSGTYS--TYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLttVYHLHNWRQ-----KRG-
 . .||||| .|   ..|..    |   ..     |  ...    ..||. | . . | . |     |..  .| .. |.   .. ..| .     . . 
tlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpreeds

LEVVTDLVATMEKVMKVNDNT------VLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
    ..|......| ......      .    .| ||.||...| .|.  ... |.|.  . .. || .|. .|.  .|.  ...... . . 
slstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
0036282 (Phosphotyrosine protein) phosphatases II 189-370 9.7e-10 33.9 In-house 17-163 (174) alignment 
Range on Protein: 189-370
Range on HMM: 17-163/174.0
RTMILTQVPDLssapdiadFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGtystygkmfvnnkkvesavgmteycleifpdgCSNSLLTTVYHLHNWR
.  |..|.|          ||.|.....| .||    . |  |  .  . .                                  ...|  ...... . 
prliagqgpla........fwemlkelgittvvmlleekelglykcinywpe................................lredlerlgiqylylp

--Q--KRGLEVVTDLVATMEKVMKV--NDNTVLMSMNGTGRAGTMLTLFTAMLQVQkGKEVNAKETLASLRAERCGIVDNIDQFGTVH
        |... ..|  .|....   .  ..   . | ||.||.  ..  . .    . |.| .....||  |.|.| . .|.  ..
wpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 171-339 1.2e-09 32.3 In-house 63-229 (281) alignment 
Range on Protein: 171-339
Range on HMM: 63-229/281.0
NGPESFICAAKITVPDFNRTMILTQVPDLSSApdiADFWRMIHQESIASVVIAVMPLEVTLQQ---ILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLE
.    .| |  |  | ..|  |||| |   .    ||||||| ||  ...|. .  ||   ..    .|  .     . |. |. .       .    |.
knstdyihanyirspflkrgyiltqgpkketr...adfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrln

IFPDGcsNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQK
.  .|  .. | | .  ..| . .  |    ..  . |.       |.    | ||.||....  |.  .. 
lsyeg..etrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihs
subfamily_PTPN6_pd Subfamily PTPN6 179-383 1.4e-09 32.4 In-house 86-303 (306) alignment 
Range on Protein: 179-383
Range on HMM: 86-303/306.0
AAKIT--VPDFNRTMILTQVPdLssAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLL--SGTYSTYGKMFVNNKKVESavgMTEYCLEIFPD---
|  |.  |.. ... | ||   |     ..|||||. ||.   .|.. . .| . ..  .    . . ..|||. |.| . .|   ...| |  .     
anyikkevkgsdksyiatqgc.l..ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseks...ladYilRelsvskk

-GCSNSLLTTVYHLHNWR-----QKRG--LEVVTDLVATMEKVMKV-NDNTVLMSMNGTGRAGTMLTLFTAMLQVQ---KGKEVNAKETLASLRAERCGI
   ...     || ..|      ...|  |. ..|. . .|....  .  .|    .| || ||.. . . . ...      ... ...  |.|. | |.
kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsgl

VDNIDQFGTVHRSMACWFKNNSTN
|   .|.  |..... . ..... 
vqteqqykfvykaikkyietkkkl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 167-371 2.2e-09 31.9 In-house 27-234 (239) alignment 
Range on Protein: 167-371
Range on HMM: 27-234/239.0
VKLTNGPES-FICAAKITVPDF-NRTMILTQVpdlSSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEY
 ||.| | | .| |. .   |   .. | ||    . ...  |||||. ||  . .|.    .|   ..       . | | .. |  .| |        
eklsndphsdyinasylrdydgspkayiatqg...cveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiir

CLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIV
 . .   | ..      ||.  | .|   .  | ..    |. | .       |.    | ||.|..| . . . | .| | |.  . . ..| .|  .|
tfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmv

DNIDQFGTVHR
.  .|.  .| 
qtseqyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 167-371 2.4e-09 31.7 In-house 28-235 (239) alignment 
Range on Protein: 167-371
Range on HMM: 28-235/239.0
VKLTNGPES-FICAAKITVPDF-NRTMILTQVpdlSSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEY
 ||.| | | .| |. .   |   .. | ||    . ...  |||||. ||  . .|.    .|   ..       . | | .. |  .| |        
eklsndphsdyinasylrdydgspkayiatqg...cveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiir

CLEIFPDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIV
 . .   | ..      ||.  | .|   .  | ..    |. | .       |.    | ||.|..| . . . | .| | |.  . . ..| .|  .|
tfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmv

DNIDQFGTVHR
.  .|.  .| 
qtseqyvfihl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 137-381 3.7e-09 30.6 In-house 39-294 (310) alignment 
Range on Protein: 137-381
Range on HMM: 39-294/310.0
FKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLTN---GPESFICAAKITVPDFNRTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLEVTLQQ
 . .  .  ..|..||| |  |    ..  |||.      | .| |  .    .  |.| .| |       | |||||| ||   |... .   |    .
kqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqh...tiidfwrmifqeraesilllckvgeegrpk

---ILPLLsGTYSTYGKMFVNNKKVES-AVGMTEYCLEIFPDGCS-----NSLLTTVYHLHNWRQKRGLEVVTDLVATMEK--VMKVN-DNTVLMSMNGT
     | | |   ||| . | |    |    . . .. . ||          |      | .| .     |  . . |. .  . .|     |.    | 
cvgywpsl.gvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagk

GRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKNNS
.| .....|  .. ....|..|.|.|  . |. .|   ...  |.  ..| .  . . ..
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarget
0043147 (Phosphotyrosine protein) phosphatases II 175-370 4e-09 31.9 In-house 6-154 (172) alignment 
Range on Protein: 175-370
Range on HMM: 6-154/172.0
SFICAAKITVPDFNRTMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVmPLevtlqqilpllsgtystygkmfvnnkkvesavgmteycleiF-----
 .| |  . ..   .  | || |      ..||||||.... |  .| .  .|                                         .     
dyinasyldlyyipdrfiatqgp...lrntladfwrmlkelgithivnlt.el.........................................lydpel

-------------PDGCSNsLLTTVYHLHNWRQK--R--GlevvtdlvatmekvmkvNDNTVLMSMNGTGRAGTMLTLFTAMlqvqkgKEVNAKETLASL
             ||..   ||  .... .. ..                       .  ..   . | ||.||.  ..  .      . ... |..| .
lerlgiqylylpwpDhgvp.llellleflefidellalsp.................ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalv

RAERCGIVDNIDQFGTVH
|. |.|.| | .|   ..
rekRpgavqnpsqyrfly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 146-377 4.4e-09 30.7 In-house 31-270 (285) alignment 
Range on Protein: 146-377
Range on HMM: 31-270/285.0
SFKNNMHKIRAPDCPIPEEKLVKLTNGPESFICAAKITVPDFNR-TMILTQVPdLSSapDIADFWRMIHQESIASVVIAVMPLEVTLQQI---LPLLSGT
... |    |  |    ||  | | |    .| |. . .|  .. | | || | |     ..|||.||.|| || |.. .  .|  ...     |   | 
ayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgp.lpe..tlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

YSTYGKMFV--NNKKVESAVGMTEYCLEIF--PDGCSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTV---LMSMNGTGRAGTMLTLFTAM
   .||  .   . | |.  |    .| .    | .|. |     ..  | ..   |    ..   . | ||| .     .    | ||. |.. .  | 
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyat

LQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWF
... .  ...  . .  .|| |   |..  ||  ..  .  .|
irimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_PTPRN_pd Subfamily PTPRN 174-373 8.4e-09 29.5 In-house 84-288 (297) alignment 
Range on Protein: 174-373
Range on HMM: 84-288/297.0
ESFICAAKITVPDFNR-TMILTQVPdlsSAPDIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNnKKVESAVGMTEYCLEIFPD-
. .| |. |.  |  . . | || |    |  .||||.|. .. .. .|      |  ..|       . |   ...   . |   .   .| .  |   
sdyinasaildhdprapayiatqgp...lastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyev.hlvsehiwcddylvrsfylk

G--CSNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DNTVLMSMNGTGRAGTMLTLFTAMLQVQKG-KEVNAKETLASLRAERCGIVDNID
    |..   | .|   |...        |.    || |         |. ...|.||.|. . .   . ...|| ||..   ||  || .| |.|   |
nlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkd

QFGTVHRSM
||  .  ..
qfefaltav
subfamily_PTPN14_pd Subfamily PTPN14 143-379 1e-08 29.5 In-house 42-298 (300) alignment 
Range on Protein: 143-379
Range on HMM: 42-298/300.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLT---NGPESFICAAKI--TVPDFNRTMILTQVPDlssAPDIADFWRMIHQESIASVVIAVMPLE---VTLQQI
|. . ..| .| | .|    |.  |.|.   .  . .| |..|  .|   .|. | .| |       . |||.|. .. .. .|.     |       . 
staklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl...eltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

LPLL--SGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPdgCSNSLLTTVYHL--HNWRQKRGLEVVTDLVATMEKVMKVNDN-------------TVLMS
.| |  .    ..||  | .| .|..  ..  .|..       .   ||.||   .| ...  | |.. .  .|.|  |  .              ..  
fPkleskkktvefgkfkvttkfsedsdsvittglklkh..lpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhC

MNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
 .| ||.| ...    .  .....|.. |..|| ||  |  .|... |.  |.. .  ..||
saGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 152-365 6.5e-08 26.7 In-house 52-269 (301) alignment 
Range on Protein: 152-365
Range on HMM: 52-269/301.0
HKIRAPDCPIPEEKLV-KLTNGPESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEV---TLQQILPLLSGTYSTYGK
.| | |  |   .  |  ...|    | |  |  .   . .| || | |...    ||| |. |  .  .|.    .|      .. ||.  .     |.
dkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgP.lknt..sedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

MFVNNKKVESAVGMTEYCLEIFPDGCSNSL-LTTV--YHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVN
  .. |. |. .    .  ..     .. .   ||  |  ..| ..   .  ..|   || | | ..  |.   .| ||. ....      .|.  ....
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptie

AKETLASLRAERCGIVDNIDQ
 .|.|. || .|   | .  |
ltealkhlrehrwngvqtnsq
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 177-372 6.5e-08 27.1 In-house 32-234 (237) alignment 
Range on Protein: 177-372
Range on HMM: 32-234/237.0
ICAAKITVPD-FNRTMILTQVPDLSSapdIADFWRMIHQESIASVVIAVMPLEVT---LQQILPLLsGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDG
| |. .   |   .. | .| |  ||     |||.|. ||  . .|.    .|       .  |      ..||.. |  || |     |  .| ..  .
inatylkgfdgtpkkyiaaqgpless...cddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvltvslkkkeefsdytvrslllskrl

CSNSL-LTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVN----DN--TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQ
  . . |   |..  | ..   .  . |.    .... .    .    ..    | ||.| .| . . . | .. | |.  . . |.  .|  |..  ||
tlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdq

FGTVHRS
.  .|..
yvfihqt
subfamily_egg_pd Subfamily egg 148-379 1.2e-07 25.7 In-house 38-272 (307) alignment 
Range on Protein: 148-379
Range on HMM: 38-272/307.0
KNNMHKIRAPDCPIPEEKLVKL--TNGP--ESFICAAKITVPDFNRTMILTQVPdLSSApdIADFWRMIHQESIASVVIAVMPLEVTL-QQILPLLSGTY
.||..| |..  .  .   |||   .|   . || | ..    .  ..||.| | |  .    |||||..|| .  .|.     |    .   |      
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqap.lknt..vddfwrmvfqeevqyivmltsrkeserceyywpkaesds

STY--GKMFVNNKKVESAVG----MTEYCLeIFPDgcsnsllTTVYHLHNWRQK-RGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAML
  .  | . ..| ||.|.      .|.  | . .|           .|  |.   . .  |   .  . |. ..   .|. ...|  .|.|.... .|.|
lvtvpGslrienlkvdskadplfrvtklkl.vGgd.......deerflehwqgdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiall

QVQKGKEV--NAKETLASLRAERCGIVDNIDQFGTVHRSMACWFKN
.. .|  .    ...   || .|   |. . ..  |.| .. .|..
sllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
0049260 (Phosphotyrosine protein) phosphatases II 204-370 1.5e-07 26.7 In-house 21-143 (152) alignment 
Range on Protein: 204-370
Range on HMM: 21-143/152.0
DIADFWRMIHQESIASVVIAVMPLEVTLQQILPLLsgtystygkmfvnnkkvesavgmteycleifpdgcsnsllttVYHLHNWRQKRGLEVVTDLVATM
..||||||...  |  .|    .|| .  .   .                                            |. ..|      .    |   .
tladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDhgvpdlsqlllfll

EK----VMKVNDNTVLMSMNGTGRAGTMLTLFTAMlqvqkgKEVNAKETLASLRAERCGIVDNIDQFGTVH
.       . . ...   . | ||.||.  ..  .      . |...|..| .|. | |.| | .|   ..
lfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 189-373 3.3e-07 24.1 In-house 91-275 (439) alignment 
Range on Protein: 189-373
Range on HMM: 91-275/439.0
RTMILTQVPDLSsapDIADFWRMIHQESIASVVIAVMPLEVTLqqILPllSGTYSTYGKMFVNNKKVESAVGMTEYCLEIFPDGCSNSLLTTV--YHLHN
.  | ||.|         ||||.. ..  . .|     .|       |  | .   || . |   .       .   . .| .  ..    ||  .|   
klyiatqgpkke...ttddfwrlviekktvtivmltnlvesyk..ywp..sdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyia

WRQKRGLEVVTDLVATMEKVMKVNDN-----TVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVHRSM
| .|      . ..  .  .   ||.      |.    | ||.||...|  |. |..  ..|. |  .  || .|  .|... |.  .. ..
wpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 175-368 3.8e-07 24.5 In-house 47-250 (290) alignment 
Range on Protein: 175-368
Range on HMM: 47-250/290.0
SFICAAKITVPDfNRTMILTQVPDLSS----APDIADFWRMIHQESIASVVIAVMPLEVTLQ-------QILPLLSGTYSTYGKMFVNNKKVESAVGMTE
 .| | ..|.|. .  .|||| |        .  | .|| |..|| . .||      | . .       .  |   |.  ... . |. |. |   .. .
dyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet

YCLEIFPDGCSNsLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQ-KGKEVNAKETLASLRAERCGIVDN
  |..  |.  . .  | . |..| .    |    |.. ..||.. .   ..  ..|  |  .. ..  ..  .  . ..|. .. | .|| .|   . .
Relvvkfddeee.ftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaits

IDQFGT
  ... 
alelaf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 259-388 9.5e-07 22.8 In-house 169-299 (305) alignment 
Range on Protein: 259-388
Range on HMM: 169-299/305.0
VGMTEYCLEIFPDGCsNSLLTTVYHLHNWRQKRGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKE-TLASLRAERC
  .||  | |   |. ... .| ||  .| ..      . ..  .||       .|.    | ||.|... |   . |.  |. ..  .  |  .| .| 
akvtetvlviegpge.karkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrn

GIVDNIDQFGTVHRSMACWFKNNSTN-EEVQR
  ..  .|.  ||. .  .|...    |||..
nsiqtdaqylfvhqvilnyfrkkklldeevke
0051082 (Phosphotyrosine protein) phosphatases II 191-369 2.8e-06 22.5 In-house 15-145 (151) alignment 
Range on Protein: 191-369
Range on HMM: 15-145/151.0
MILTQVPdlssapdIADFWRMIHQESIASVVIAVMPLEVTlqqI----LPLLSgtystygkmfvnnkkvesavgmteycleifpdgcsnsLLTTVYHLHN
..... |        |||....... | ..|    . |          || |.                                     .  . .....
lyrsggp.......ladflellkelgiktivnlrseeerg...ycpeylpelg.....................................ievlhipild

WRQKRGLEVVTDLVATMEKVMKV-NDNTVLMSMNGTGRAGTMLTLFTAMLQvqkgkeVNAKETLASLRAERCGIVDNIDQFGTV
|      .    ... .|....  | ...   . | || ||.  |.  .|.      |.. |.|. .|. |.|.|   .||  .
wpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq
0044763 (Phosphotyrosine protein) phosphatases II 192-372 3.5e-06 22.3 In-house 31-166 (178) alignment 
Range on Protein: 192-372
Range on HMM: 31-166/178.0
ILTQVPDlssapdiADFWRMIHQESIASVVIAVMPLEVTLQQILPLLS---GtystygkmfvnnkkvesavgmteycleifpdgcsnslltTVYHLHNW-
.|.. |.       ||........ | ..|    .||   .. .|      |                                         |.  .. 
ylgslpp.......addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipip

-RQKRG-LEVVTDLVATMEKVM-KVNDNTVLMSMNGTGRAGTMLTLFTAMLQvqkgkEVNAKETLASLRAERCgIVDNIDQFGTVHRS
       || . ..|. .|... . . ...   . | ||.||.  ..  . .      ... | .. .|. |. || | .|   ... 
DhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyef
subfamily_PTPN9_pd Subfamily PTPN9 250-373 4.4e-06 20.9 In-house 164-286 (297) alignment 
Range on Protein: 250-373
Range on HMM: 164-286/297.0
VNNKKVESAVGMTEYCLEIFPD-GCSNSLLTTVYHLHNWRQKRGLEVvTDlVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFTAMLQVQKGKEVNAKET
..| | |    .| . .  .|| |  .|  . .  |.. |.|..| | .. ..  .|    .   |.    | ||.||. ||  .. ....   |.  ||
iknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalav.ke.lgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvet

LASLRAERCGIVDNIDQFGTVHRSM
.  ||. |   .   .|.   . ..
vkllrtqrafsiqtpeqyefcylav
subfamily_DSP23_pd Subfamily DSP23 291-370 4.7e-06 21.3 In-house 65-139 (148) alignment 
Range on Protein: 291-370
Range on HMM: 65-139/148.0
RGLEVVTDLVATMEKVMKVNDNTVLMSMNGTGRAGTMLTLFtamlqVQKGKEVNAKETLASLRAERCGIVDNIDQFGTVH
  || | ..|  .|.  . |.   .  . | ||.||||. .     . | ... | |..| .|  | | |. ..|   |.
paleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacy.....lvkerklaaaeaiaevrrlrpgsvetveqeklvr