Gene C16A3.2 in Caenorhabditis elegans

Synonym: CELE_C16A3.2, C16A3.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP15
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP018_AA protein Get Run
CeleP018_AA_41-190 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP15_pd Subfamily DSP15 43-197 3e-69 225.9 In-house 1-150 (151) alignment 
Range on Protein: 43-197
Range on HMM: 1-150/151.0
KISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDrevvnykNNQKFIKN--YRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSA
.||..||.|||.....|...|||||||||....|.|       |..|..|.  |...|.|||.|||......|.|..||..|.|||.|||||..|||||.
giskvlpglylgnfrdskdeelLkeknithilsvhd.......nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsv

TLVAFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYSTTKAKEFRNQLISE
|||..||......|||||...|...|..||||||| .|||.|..||.||.|.||..|
tlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrkqlkee
PTPc_motif_SM00404 44-183 5.4e-39 128.3 In-house 2-138 (140) alignment 
Range on Protein: 44-183
Range on HMM: 2-138/140.0
ISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDREVVNyknNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLV
.|.|||.|||.. . .||..|||...||.||||..  ...   ...  ...  . ..|. ..|.   .......|.....|.. |||||..||||||||.
psrilphlylgskskaqnpallkklgithvinvteevslt...kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatli

AFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYS
..||..  ......|..|...|| . .||..|..||  | 
iaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
0044763 (Phosphotyrosine protein) phosphatases II 42-183 6e-34 112.6 In-house 21-167 (178) alignment 
Range on Protein: 42-183
Range on HMM: 21-167/178.0
RKISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDREVVNYKNNQKFI-----KNYRFYAMSDTASAKFDGIIEEAVRIIHDSR-SKEEGVLVHCFLG
  .|||||.|||..   ... ||||| .||...|...    .. .. .        .|... ..|      . ...|.|..|.. . .|.. |||||  |
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

VSRSATLVAFYLISALSINWRDAVDFIHHRRFsANPNFGFLHQLKVYS
|.||.|||| ||.  |.... .|..... ||. ..||.|.|.||. . 
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefe
subfamily_DSP6_pd Subfamily DSP6 34-184 1.2e-32 106.6 In-house 4-152 (158) alignment 
Range on Protein: 34-184
Range on HMM: 4-152/158.0
TKLHNLSSRKISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDREVVNYKNNQKFikNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCF
.||.. ...   ||||.|||  .. ..|.|.||. .|  |.||       .......  .|   ...| .|...   . ||.. | ..|||...|||||.
dklkkaeaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgel..kylqipiedhlsqnlakffPeaiefidearskkskvlvhCl

LGVSRSATLVAFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYST
 |.||| |..  ||.. | .   || |....|. .  ||| |. ||. .  
aGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfer
0043147 (Phosphotyrosine protein) phosphatases II 42-184 1.7e-32 107.9 In-house 17-158 (172) alignment 
Range on Protein: 42-184
Range on HMM: 17-158/172.0
RKISEILPNLYLSGRTVSQNSELLKEKNITTVINVSdREVVNYKNNQKFIKNYRFYAMSDTASAkFDGIIEEAVRIIHD--SRSKEEGVLVHCFLGVSRS
... ........ ..|.... ..|||..||...|.  ........ ....  | .. . |        ...|....|..   .|... |||||  ||.|.
yipdrfiatqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRt

ATLVAFYLISaLSINWRDAVDFIHHRRFSANPNFGFLHQLKVYST
.|||| ||.  |.... .||... ..|. | .|......|. .. 
gtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfek
subfamily_DSP12_pd Subfamily DSP12 44-188 2.6e-32 106.3 In-house 2-145 (155) alignment 
Range on Protein: 44-188
Range on HMM: 2-145/155.0
ISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDREVVNYKNNQKFIKnYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLV
.|.|||.|||.| .  |. ||||| .|| |. |  .|. ..|.... .. ..|  . |. ..     ..|||. |......|. |||||. |||||.|.|
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvs.tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiv

AFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYSTTKAK
. ||.    ..  .|...... . ...|| |||.|||..   . |
iAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck
subfamily_DSP1_pd Subfamily DSP1 44-190 4.4e-32 105.4 In-house 18-160 (163) alignment 
Range on Protein: 44-190
Range on HMM: 18-160/163.0
ISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDReVVNYKNNqkfIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLV
. .||. ||| ..||. | |.||...|| ..||| . . |. ..   . .|.   ..|. .|    ..||..  |.. ..|.  ||.||  |.|||.||.
vekildfLylGsetvasnleiLkslgitailnvske.ldnvfed...lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlc

AFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYSTTKAKEF
  ||..   ..  .| ||...||   .||.||  ||. | ..  .| 
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklllel
0048179 (Phosphotyrosine protein) phosphatases II 44-183 3.1e-31 103.4 In-house 4-141 (144) alignment 
Range on Protein: 44-183
Range on HMM: 4-141/144.0
ISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDRevVNYKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLV
.|||||.|||..  .... ||||. .||||||...     .    ... .| .. . |     .  ...|....|.. ..... |||||  ||.|..|||
pseilpglylgslptaldlellkklgittvinltee..yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

AFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYS
| ||.  | ... .|..... ||. |.||.|.|..|. |.
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleye
0048076 (Phosphotyrosine protein) phosphatases II 44-183 7.5e-31 102.1 In-house 4-139 (145) alignment 
Range on Protein: 44-183
Range on HMM: 4-139/145.0
ISEILPNLYLSGRTVSQNSELLKEKNITTVINVsdreVVNYKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLV
.|||||.|||.. .. .. ||||. .||||.|.      . ..  ... .| .. . |     .  ...|....|.. ..... |||||  ||.|..|||
pseilpglylgslptaldlellkdlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlv

AFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYS
| ||.  |.... .|..... .|. |.||.|.|..|. . 
aaylmlllgvsleealelvrsqrpgavpnpgqlrflyefe
0041856 (Phosphotyrosine protein) phosphatases II 40-190 8.8e-31 102.3 In-house 15-176 (182) alignment 
Range on Protein: 40-190
Range on HMM: 15-176/182.0
SSRKISEILPNLYLSGRTV--------------SQNSELLKEKNITTVINVSdREVVNYKNNQKFIKNYRFYAMSDTASAKfdgiIEEAVRIIHDSRSKE
 || ...|..||||...                 .. ..||| .|||..|..  |  .... .. . .|... . |         ..|....|.. ....
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeg

EGVLVHCFLGVSRSATLVAFYLISALSINWRDAVDFIHHRRF--SANPNFGFLHQLKVYSTTKAKEF
. |||||  ||.|..|||| ||.  |......||...  ||.    .||..|. ||...   . |..
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
DSPc Dual specificity phosphatase, catalytic domain 51-183 2.2e-30 100.3 Pfam-A 1-131 (133) alignment 
Range on Protein: 51-183
Range on HMM: 1-131/133.0
LYLSGRTVSQnSELLKEKNITTVINVSDREVVNYKNNQKFIKNYRFYaMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLVAFYLISA
|||.. . ..  .||....|| ||||...   |.. ... |.. |   . |. ..|.   .||||..|.. ..|.. |||||  |.||||||.. ||.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

LSINWRDAVDFIHHRRFSANPNFGFLHQLKVYS
 ... ..|..|.  || . .||.|||.||  | 
knlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 51-183 2.2e-30 100.3 In-house 1-131 (133) alignment 
Range on Protein: 51-183
Range on HMM: 1-131/133.0
LYLSGRTVSQnSELLKEKNITTVINVSDREVVNYKNNQKFIKNYRFYaMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLVAFYLISA
|||.. . ..  .||....|| ||||...   |.. ... |.. |   . |. ..|.   .||||..|.. ..|.. |||||  |.||||||.. ||.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

LSINWRDAVDFIHHRRFSANPNFGFLHQLKVYS
 ... ..|..|.  || . .||.|||.||  | 
knlslneAyefvkerrskispnagflrqLleye
subfamily_DSP19_pd Subfamily DSP19 43-186 7.9e-29 95.0 In-house 11-150 (152) alignment 
Range on Protein: 43-186
Range on HMM: 11-150/152.0
KISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDREVVNYKNNqkFikNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATL
...|. |.|||.   | ...| ||||.|| ..||.   .  . ..  |  .|    . |.  ..   ...||.  |...|||.  |||||  ||||||..
evgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkd..f..tylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasv

VAFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYSTTK
|  ||..  ... ..|.. ... | ...|| ||..||| | ...
viaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
0049260 (Phosphotyrosine protein) phosphatases II 45-183 4.3e-28 93.3 In-house 9-146 (152) alignment 
Range on Protein: 45-183
Range on HMM: 9-146/152.0
SEILPNLYLSGRTVSQNSELLKEKNITTVINVSDREVVNYKNNQKFIkNYRFYAMSDTASAKFDGIIEEAVRIIHD-SRSKEEGVLVHCFLGVSRSATLV
 |....... . |.... ..||| .|||.... ...  ..    . | .| .. . |    ... ........|.   ..|.. |||||. ||.|..|||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

AFYLISaLSINWRDAVDFIHHRRFSANPNFGFLHQLKVYS
| ||.  | ... .||...  .|  |.||.|.| .|. ..
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefe
subfamily_DSP14_pd Subfamily DSP14 41-187 6.3e-28 91.7 In-house 4-145 (157) alignment 
Range on Protein: 41-187
Range on HMM: 4-145/157.0
SRKISEILPNLYLSGRTVSqNSELLKEKNITTVINVSDrEVVNykNNQKFIKNYRFyAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSA
 ...|.| |.|.|||.... . ||||.|.||..|||.  |..|  .. | |.. .  ...|. .||     .|..  |.. . |.  .||||  ||||||
laalsqitpsLflsgvaal.skellkkkkitliinvtv.elpn..tklkdiervkv.pveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSA

TLVAFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYSTTKA
.|.  ||.   ... |.|   ....|   .|| || .||  | .   
slclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklk
subfamily_DSP10_pd Subfamily DSP10 38-185 1.3e-27 90.6 In-house 8-152 (159) alignment 
Range on Protein: 38-185
Range on HMM: 8-152/159.0
NLSSRKISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDREVVNYKNnQKFikNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVS
.. . ..|..|| |.|   . ... ..|.. |||.|.||  .   .... ...  .|.   .||| . .     |||.  |.. |.|.. |||||  |.|
dietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.eal..kYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGis

RSATLVAFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYSTT
||||.|  ||.  |... .|| .|....|    ||..|. ||. .  .
rsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
0046846 (Phosphotyrosine protein) phosphatases II 44-183 1.3e-26 88.8 In-house 12-169 (176) alignment 
Range on Protein: 44-183
Range on HMM: 12-169/176.0
ISEILPNLYLSGRT----------VSQNSELLKEKNITTVINVSDRE-------VVNYKNNQKFIKNYRFYAMSDTASAKFdGIIEEAVRIIHDSRSKEE
...|..||.|..|           . .. |.||| .||.|.|. ..           ..  .|.   | .. . |     .  ...|....|.. ... .
ldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkegg

GVLVHCFLGVSRSATLVAFYLISA-LSINWRDAVDFIHHRRF-SANPNFGFLHQLKVYS
 |||||. |..|..|||| ||.     ... .|....  .|.  | ........|. . 
pvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefe
0045098 (Phosphotyrosine protein) phosphatases II 37-182 8.8e-26 86.3 In-house 15-267 (278) alignment 
Range on Protein: 37-182
Range on HMM: 15-267/278.0
HNLSSRKISEILPNLYLSGRT-----------------------------------------VSQNSELLKEKNITTVINVSDREVVN------------
..|.   .|||.|.|||...                                          |... ..|.| .||..... . .  .            
fllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpegg

----------------------------------YKNNQKFIKNYRFYAMSDTASAKFD--GIIEEAVRIIHDSRS--------------KEEGVLVHCF
                                  . . . ... . .. . |  .  ..    . |... |.. ..              ... ||||| 
sltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCs

LGVSRSATLVAFYLISAL---SINWRDAVDFIHHRRFS-ANPNFGFLHQLKVY
 ||.|..|||| ||.  |    ... .||...  .|   | .|......|  .
aGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyef
subfamily_LRR-DSP_pd Subfamily LRR-DSP 24-184 1e-25 84.4 In-house 100-256 (263) alignment 
Range on Protein: 24-184
Range on HMM: 100-256/263.0
GNIPMDASKSTKLHNLSSRKISEILPNLYLSGRTVSQNSELLKEKNITTV-INVSDREVVnYknnQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSR
 ..|..  .  .|  | |   .||...|.| |.  ..|  .||....| . . |.| | . .    |  | .    . |.  |.     ||    |.. |
islpveykqveslitlvssvPdeiidklflGgldsannksilkdlgvthillavadfePl.f...PklfkylsiddiedvdeadisqhfeetnafieeGr

sKEEGVLVHCFLGVSRSATLVAFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYST
 |. ||||||  |||||.|||  ||.   ......|.|.. ..|   .|| ||..||| |  
.kkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
subfamily_DSP3_pd Subfamily DSP3 36-187 1.4e-25 83.8 In-house 3-158 (162) alignment 
Range on Protein: 36-187
Range on HMM: 3-158/162.0
LHNLSSRKISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDREVVNYKNNQKFIK----NYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEG-VLV
|..| |... |. |.||.....|... . ||.  || |.| .. .... . ...| |    .|    ..|. .....   |.|.. |... |..|| |||
lerllskevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlv

HCFLGVSRSATLVAFYLISALSINWRDAVDFIHHRRfSANPNFGFLHQLKVYSTTKA
||  |||||||||  ||.   ...  .|.  ....| .  || |||.||. ...  .
hcvvGvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelk
0042113 (Phosphotyrosine protein) phosphatases II 38-182 1.4e-25 85.6 In-house 41-238 (245) alignment 
Range on Protein: 38-182
Range on HMM: 41-238/245.0
NLSSRKISEILPNLYLSGRTVSQNSE----LLKEKNITTVINVSDREVVN------------------------------------------YKNNQKFI
| |  . ..| |......   ... |    .|.| .|||...... |  .                                          ... ....
nasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrev

KNYRFYAMSDTASAKFDGIIEEAVRIIHDSRS--KEEGVLVHCFLGVSRSATLVAFYLI-----SALSINWRDAVDFIHHRRFSANPNFGFLHQLKVY
 .|... . |   .  . ........... ..  ... |||||  ||.|..|..| ||.     . | ... .||...  .|  | ........|  .
ihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
subfamily_DSP8_pd Subfamily DSP8 42-183 1.7e-25 83.4 In-house 13-151 (159) alignment 
Range on Protein: 42-183
Range on HMM: 13-151/159.0
RKISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDREVvnyknNQKFIKNYRFY--AMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRS
 .. .||.||||  .... ..|||....|. |.|.|   .     .....|. .|    . |. . |.  .....|  |   .|..  ||||.. | |||
vgptrilknlylGsqkdvlseellsklgisyvlnasnscp.....kleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrs

ATLVAFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYS
||..  |..  |...  .|  |....| . .||. || ||  | 
atvaiayimktlemsldeayrfvkekrptispnlnflgqLleye
0037934 (Phosphotyrosine protein) phosphatases II 45-182 2.7e-25 84.8 In-house 40-237 (243) alignment 
Range on Protein: 45-182
Range on HMM: 40-237/243.0
SEILPNLYLSGR--------TVSQNSELLKEKNITTVINVSDRE-----------------------------------------VVNYKNNQKFIKNYR
....|.|....         .. .. ..|.| .||..... . .                                          ..... .... .| 
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

FYAMSD----TASAKFDGIIEEAVRIIHD-----SRSKEEGVLVHCFLGVSRSATLVAFYLISAL-SINWRDAVDFIHHRRFS-ANPNFGFLHQLKVY
.... |    .  . .  ...|.  .|..      ..... |||||  ||.|..||.| ||.  | .... .||...  .|.  | ........|  .
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0036282 (Phosphotyrosine protein) phosphatases II 37-182 4.9e-25 83.6 In-house 5-165 (174) alignment 
Range on Protein: 37-182
Range on HMM: 5-165/174.0
HNLSSRKISEILPNLYLSGRTVSqNSELLKEKNITTVINVSDREVVN-----------YKNNQKFIKNYRFYAMSDTASAKFDGiIEEAVRIIHDSRSK-
.| |  ..|.|.|.|....   . . |.||| .||||... . .  .           ..   ... .| .. . |     ..  ..|.|..... .|. 
inaspldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsed

-EEGVLVHCFLGVSRSATLVAFYLISALSI-NWRDAVDFIHHRR---FSANPNFGFLHQLKVY
 .  |||||  ||.|..|||| ||.  . . . .||.|... .|     . ........|  .
pggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
PTEN_1 39-182 1.4e-24 82.0 In-house 35-187 (196) alignment 
Range on Protein: 39-182
Range on HMM: 35-187/196.0
LSSRK-ISEILPNLYLSGRTVS-QNSELLKEKNITTVINVSDREV---VNYKNNQKFIKNYR--FYAMSDTASAKFDGIIEEAVRIIHDSRS--KEEGVL
 .||. ..|| ..||.  ..   .. . |||..||.|.|.|..|    ..| ... | ....   . . |     .. ........|.  .|  ... ||
apsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVl

VHCFLGVSRSATLVAFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVY
|||  |..||.|.|| ||...   . ..|....  .|  ..|| ... .|. |
VHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlley
0049772 (Phosphotyrosine protein) phosphatases II 55-183 4.5e-24 81.2 In-house 156-270 (314) alignment 
Range on Protein: 55-183
Range on HMM: 156-270/314.0
GRTVSQNSELLKeknittvinvsdrEVV-NYKNNQKFIKNYRFYAMSDtASAKFDGIIEEAVRIIHDSrSKEEGVLVHCFLGVSRSAT-LVAFYLISALS
.  . .. ||||             |.. . .  .. . .|  . ..|  ||  . ...|....|..  .|.. |||||  |..|..| .|| ||...| 
neptaadlellk.............eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllg

INWRDAVDFIHHRRFsANPNFGFLHQLKVYS
.....|..... .|. .|||.||..||. | 
vsleealedvrlkRp.inpnpgfieqleqye
0051082 (Phosphotyrosine protein) phosphatases II 44-182 4.3e-23 77.0 In-house 8-149 (151) alignment 
Range on Protein: 44-182
Range on HMM: 8-149/151.0
ISEILPNLYLSGRTVSQNSELLKEKNITTVINVSDREVVNyKNNQKFIK---NYRFYAMSDTASAKFDGIIEEAVRIIHDSRSK-EEGVLVHCFLGVSRS
.| . ..||.||   ... ||||| .|.|..|. . |  . .. . . .   ... . . |.   ... ..........  ..| .  |||||  |..|.
fsyvtgglyrsggpladflellkelgiktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

ATLVAFYLISaLSINWRDAVDFIHHRRF-SANPNFGFLHQLKVY
.|||| ||.  | ... .|..... .|. . .|| .|| ||...
Gtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_STYX_pd Subfamily STYX 41-187 4.5e-23 75.2 In-house 9-158 (166) alignment 
Range on Protein: 41-187
Range on HMM: 9-158/166.0
SRKISEILPNLYLSGRTVSQNSEL--LKEKNITTVINVSDREVVNYKNnQKFIKNYRfYAMSDTASAKFDGII---EEAVRIIHDSRSKEEGVLVHCFLG
 |.. |||| |.|   . ...| |  ||.. || .. . .    |.    .| ...| | . | | .  . ||    .   .| || .|   ||||   |
rremqeilpglflgpysaamksklevlkkhgithivcirqnieanlik.pnfpdrfr.ylvldvadntveniirylptvkefiddslqkggkvlvhgnag

VSRSATLVAFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYSTTKA
.||||.||  |.. .  ...|.|  .. .|||  ||| || .|||.| .   
isrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyl
subfamily_Slingshot_pd Subfamily Slingshot 43-184 6.2e-23 75.0 In-house 18-155 (169) alignment 
Range on Protein: 43-184
Range on HMM: 18-155/169.0
KISEILPNLYLSGRTVSQNSELLKEKNITTVINVSdREVVNYKNNQKFIKNYRFYamsDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATL
. |.|   .||     . | | |||.... ..||. .|. |. ...   .| | |   |. ....    .|. . |. ...|.  ||||| .||||||. 
saskifdhvylGsewnasnleelkengveyilnvt.keidnffpekfeylnirvy...deeetdllkywnetykfiekakkkgskvlvhckmGvsrsast

VAFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYST
|  | . . ...  .|......||  ..|| |||.||..|. 
viayamkeyglsleealeyvkerrsvikPnkgflkqleeyeG
0040439 (Phosphotyrosine protein) phosphatases II 41-182 7.5e-23 76.8 In-house 26-241 (249) alignment 
Range on Protein: 41-182
Range on HMM: 26-241/249.0
SRKISEILPNLYLS------------------------GRTVSQNSELLKEKNITTVINVSDREVVN---------------------------------
|| . .|||.|.||                          ||. . ..|.| .||....... .  .                                 
srvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddyt

---------YKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRS---KEEGVLVHCFLGVSRSATLVAFYLI-----SALSINWRDAVDFIHHRR
         |...   .. .... . |.   ..  .. . ...... ..   |.. |||||  ||.|..|..| ||.       | ..  .||... ..|
vrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR

FSANPNFGFLHQLKVY
. | .|.... .|  .
pgavqnpeqyrflyea
0045450 (Phosphotyrosine protein) phosphatases II 9-181 4.6e-22 74.6 In-house 26-298 (307) alignment 
Range on Protein: 9-181
Range on HMM: 26-298/307.0
PNGFRSCYDKLRKAVGNIPMDASKSTKLHNLSSRKISEILPN------------------------------LYLSGRTVSQNS---------------E
..|..  . ||..    .... | . ...| . . ...|||.                              |.|.|  ....                .
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

LLKEKNITTVINVSDREVVN--------------------------------------------YKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIH
.|.|...|....... .  .                                            ....  ... . ...  |.   ..  .. . .....
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

DSRS---KEEGVLVHCFLGVSRSATLVAFYLISALS--------INWRDAVDFIHHRRFSANPNFGFLHQLKV
. ..   |.. |||||  ||.|..|..| ||.  .         .....||...  .|  | .|......|  
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 49-184 4.5e-21 68.8 In-house 8-150 (154) alignment 
Range on Protein: 49-184
Range on HMM: 8-150/154.0
PNLYLSGRTVSQNSELLKEKNITTVINV-SDREVVNY----KNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSR--SKEEGVLVHCFLGVSRSAT
 .||.|    . |  .|..|||. ..||    . .        |. || .|    . | .  .    .. |   |.|.    ....||||.  ||||||.
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

LVAFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYST
|.  ||.  |.|..  |. ...  |.  .|| |||.||...  
llisylmdklkislslalellkdsryiikPnqGflkqleifek
0039614 (Phosphotyrosine protein) phosphatases II 63-182 2.7e-20 68.5 In-house 119-284 (297) alignment 
Range on Protein: 63-182
Range on HMM: 119-284/297.0
ELLKEKNITTVINVSDREVVNY--------------------------------------KNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRS-
....| ..|..... . .  .                                       ..  .... . .. . |        .. |....... .. 
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--KEEGVLVHCFLGVSRSATLVAFYLI-----SALSINWRDAVDFIHHRRFSANPNFGFLHQLKVY
  |.. |||||  ||.|..|..| ||.     .   ... .||...  .|  | ........|  .
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 45-182 1.4e-19 64.1 In-house 8-143 (148) alignment 
Range on Protein: 45-182
Range on HMM: 8-143/148.0
SEILPN-LYLSGRTVSQNSELLKEKNITTVINVSDrEVVNYKNNQkFIkNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLV
||| .  |.|  .    . | ||. ..| ..| .  |  |  ...  | .|   |..|        | |...  ..  ... . ||||. .|||||. |.
seikdafLFlGskksaadlealkalgvtrivnatk.erdnaldqr.gi.eYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssala

AFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVY
 ..||    .  ..|..... .|   .|| |||.||  .
llwlidfkrvslkealalvkskrryvdpnlgfLkqLael
0038934 (Phosphotyrosine protein) phosphatases II 69-188 1.2e-18 63.0 In-house 56-178 (194) alignment 
Range on Protein: 69-188
Range on HMM: 56-178/194.0
NITTVINVSDREvvNYKNNQKFIK---NYRFYAMSDTASAKFDGIIEEAVRIIHD--SRSKEEGVLVHCFLGVSRSATLVAFYLISALSINWRDAVDFIH
....||...  |   | . ..| |    |  . . |  ..  . |. . ......  ...... |.|||  |..|..|||| |||  | .. ..|.... 
klglvidltnte..ryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfr

HRRFSANPNFGFLHQLKVYSTTKAK
 .| .| || ..|..| ..  .  |
ekRpgaipnqdyleallkrykelrk
0040438 (Phosphotyrosine protein) phosphatases II 59-182 3.5e-18 61.4 In-house 100-271 (317) alignment 
Range on Protein: 59-182
Range on HMM: 100-271/317.0
SQNSELLKEKNITTVINVSDREVVN------------------------------------------YKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVR
    ....| ..|..... . |  .                                          ..... ... . . .  |    .   .. . ..
edFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

IIHDSRSK-EEGVLVHCFLGVSRSATLVAFYLI-----SALSINWRDAVDFIHHRRFSANPNFGFLHQLKVY
........ .. |||||  ||.|..|..| ||.         ... .||... ..|  | ........|  .
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
subfamily_STYXL1_pd Subfamily STYXL1 45-184 8.5e-18 58.0 In-house 12-151 (157) alignment 
Range on Protein: 45-184
Range on HMM: 12-151/157.0
SEILPN-LYLSGRTVSQNSELLKEKNITTVINVSDREVVNYKNNQKfIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLV
.|.||. |||     .|| .. |.  . ...|||      ..  .. . .    |..|.  |..   ..|||. |.. . ..| |||    |.||||...
vevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvad.vakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

AFYLISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVYST
. ||.    |. ..| ..... .   .|| .|..||. .  
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWek
subfamily_MKPLT_pd Subfamily MKPLT 48-182 1.1e-17 58.0 In-house 25-156 (164) alignment 
Range on Protein: 48-182
Range on HMM: 25-156/164.0
LP-NLYLSGRTVSQNSELLKEKNITTVINVSDREVVNYKNNQkfikNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLVAFY
|. .|||     ..| ..||. .|| ..|||  .  .. .      .|    ..|..  ..   .| |   . |.      |||||  |.|||..    .
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksv....eYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvaf

LISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVY
||.      ..| ... .||  ..|| ||| ||  .
LikskgwtlkeayeylkerrsivapnrGflkqlakf
subfamily_MKPLV_pd Subfamily MKPLV 48-182 1.1e-17 58.0 In-house 25-156 (164) alignment 
Range on Protein: 48-182
Range on HMM: 25-156/164.0
LP-NLYLSGRTVSQNSELLKEKNITTVINVSDREVVNYKNNQkfikNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLVAFY
|. .|||     ..| ..||. .|| ..|||  .  .. .      .|    ..|..  ..   .| |   . |.      |||||  |.|||..    .
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksv....eYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvaf

LISALSINWRDAVDFIHHRRFSANPNFGFLHQLKVY
||.      ..| ... .||  ..|| ||| ||  .
LikskgwtlkeayeylkerrsivapnrGflkqlakf
0043336 (Phosphotyrosine protein) phosphatases II 63-180 1.2e-17 59.8 In-house 106-270 (278) alignment 
Range on Protein: 63-180
Range on HMM: 106-270/278.0
ELLKEKNITTVINVSDREVVN-----------------------------------------YKNNQKFIKNYRFYAMSDTASA-KFDGIIEEAVRIIHD
....| ..||.... . .  .                                         .... ...  | .... |      .. ...   .... 
rmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrea

SRSKEEGVLVHCFLGVSRSATLVAFYLI-----SALSINWRDAVDFIHHRRFSANPNFGFLHQLK
 ..... |||||  ||.|..|..| ||.     . . ..  .||... ..|..| ... ....| 
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 46-182 1.5e-17 59.6 In-house 18-220 (272) alignment 
Range on Protein: 46-182
Range on HMM: 18-220/272.0
EILPN-LYLSGR----TVSQNSELlKEKNITTVINVSDREVVNYKNNQKFIK--NYRFYAMSDTASAKFD------------------------------
...|. ||.||.    |. .   | || .|.|.... . | ... .  ...   .| .. . |..                                   
vvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------GIIEEAVRIIHDsrskEEGVLVHCFLGVSRSATLVAFYLISaLSIN--------------WRDAVDFIHHRRFSANPNF
                       . |......|    .. |||||. |..|..|.|| .|.  | ..              ...||. .  .|  |... 
gearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqte

GFLHQLKVY
.....|  .
eqylflyea
0036941 (Phosphotyrosine protein) phosphatases II 43-182 1.2e-16 56.4 In-house 18-272 (297) alignment 
Range on Protein: 43-182
Range on HMM: 18-272/297.0
KISEILPNLYLSGRTVSQNSELLK----------------------------------------------------------EKNITTVINVSDREVVNY
  .|.||.|.|  ..|... | |.                                                          | |.|....... .  . 
efeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgr

----------------------------------------------KNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRS---KEEGVLVHCFLG
                                              ........ . .    |        .. . .. ... ..   ... |||||  |
ekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaG

VSRSATLVAFYLI--------SALSINWRDAVDFIHHRRFSANPNFGFLHQLKVY
|.||.|..| .|.            ..  .|| .. ..|. | ........|  .
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
subfamily_MSG5_pd Subfamily MSG5 69-186 4.9e-16 52.3 In-house 47-160 (165) alignment 
Range on Protein: 69-186
Range on HMM: 47-160/165.0
NITTVINVSDrEVVNYKNNQKFIKnyrFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLVAFYLISALSINWRDAVDFIHHRRFS
..  ||||.. |. . .     .|   .| .  . ..|    . .  |||| ..||.. .||||  |.||||.|.  |..   ..  ||| | .. .   
sfdlvinvak.eindlellvpavk...yyhiewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvadd

ANPNFGFLHQLKVYSTTK
 .|..|.. ||  . .. 
ispsiglifqlmeweval
subfamily_PTPMT1_pd Subfamily PTPMT1 59-185 3.3e-15 51.0 In-house 36-167 (171) alignment 
Range on Protein: 59-185
Range on HMM: 36-167/171.0
SQNSELLKEKNITTVINVSD-REVVNYKNNQKFIKNYR----FYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLVAFYLISALSI
|. .||....|. .|... .  |.  . |...  |..      .|. | . |     .|..|..|.. .|| . | |||  | .||||||| ||.    .
slikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkekl

NWRDAVDFIHHRRFSANPNFGFLHQLKVYSTT
.  .|.......|   . .   ...|. | ..
speeAlkalkkkRkiirlakkqwkalqeyeek
0051299 (Phosphotyrosine protein) phosphatases II 55-173 1.1e-14 50.0 In-house 148-272 (288) alignment 
Range on Protein: 55-173
Range on HMM: 148-272/288.0
GRTVSQNSELLKEKNITTVINVSDREVVNYKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDS-RSKEEGVLVHCFLGVSRSATLVAFYLI-----
  ||   ||  ... ..... |.. ........ .... . ...  |         . . .|..... .|..  |.|||  ||.|..|..| .|.     
ditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqle

SALSINWRDAVDFIHHRRFSANPNF
    ... .|| .. ..|. . ...
keggvdvleavkrlreqRpgmvqtp
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 51-179 1.5e-13 44.1 In-house 6-134 (145) alignment 
Range on Protein: 51-179
Range on HMM: 6-134/145.0
LYLSGRTVSQNSELLKEKNITTVINVSDREVVNYKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLVAFYLISA
||      .... .|.|  |. ..|..  ..|  .. .    .  . . .|  |  .   ..|   .|   . .  ||.|||. ||||| |.   .|.  
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

LSINWRDAVDFIHHRRFSANPNFGFLHQL
 ..   .|   .. .|. | ||  ||..|
cnmtlseaarqvrsnrllaypnvtflknl
0047943 (Phosphotyrosine protein) phosphatases II 65-179 2.3e-13 45.7 In-house 97-264 (273) alignment 
Range on Protein: 65-179
Range on HMM: 97-264/273.0
LKEKNITTVINVSDREVVN---------------------------------------------YKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIH
..|.|..... . . .  .                                               .. .... . ..   |        .. | .....
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

DSRS---KEEGVLVHCFLGVSRSATLVAFYLI-----SALSINWRDAVDFIHHRRFSANPNFGFLHQL
. ..   ... |.|||  ||.|..|..| .|.         ..  .|| ..  .|. . ... .. .|
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0046845 (Phosphotyrosine protein) phosphatases II 56-172 2e-12 42.6 In-house 135-259 (284) alignment 
Range on Protein: 56-172
Range on HMM: 135-259/284.0
RTVSQNSELLKEKNITTVINVSDRevvNYKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSK---EEGVLVHCFLGVSRSATLVAFYLISAL-
 ||   ||  |.  ..... ...    .|... .... . . .  |        .. | .|........   .. ..|||  ||.|..|..| .|.  . 
ftvtllseevkddytvrtleltnl...gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleql

-------SINWRDAVDFIHHRRFSANPN
        ..  .|| ..  .|. .  .
ekeglllgvdvleavkrlreqRpgmvqt
0050432 (Phosphotyrosine protein) phosphatases II 64-173 5.3e-12 41.1 In-house 176-285 (308) alignment 
Range on Protein: 64-173
Range on HMM: 176-285/308.0
LLKEKNITTVINVSDREvvnyKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRsKEEGVLVHCFLGVSRSATLVAFYLI-----SALSINWRDA
  ..  ..... ... .    ... .... . . .  |        |. . ......|. ... ..|||  ||.|..|..| .|.         ... .|
evlddytvrtleltnlg....dgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfea

VDFIHHRRFSANPNF
| .. ..|  . ...
vkklReqRpgmvqtp
PTPc_DSPc_SM00012 91-197 3.2e-11 38.7 In-house 2-100 (105) alignment 
Range on Protein: 91-197
Range on HMM: 2-100/105.0
IKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEE---GVLVHCFLGVSRSATLVAFYLISALSINWRdavdfihhrrfSANPNFGFLHQLKVYSTTKA
.|.| .....|.   .    | |..| ......|.|    |.|||. ||.|..|.||....     ...           .    | ....|. .  .  
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket...........kevdifqivkelrkqRpgmv

KEFRNQLISE
......|.  
qteeqylfly
subfamily_PRL_pd Subfamily PRL 56-183 6.4e-11 36.5 In-house 21-146 (151) alignment 
Range on Protein: 56-183
Range on HMM: 21-146/151.0
RTVSQNSELLKEKNITTVINVSDREVVNYKNNQKFIKNYRfYAMSDTASAKfDGIIEEAVRIIHDSRSK--EEGVLVHCFLGVSRSATLVAFYLISAlSI
 |...  | ||.....||. | .    . | ... |.    .|..| |.   . ..|| ....... ..  .. | |||  |. |.  |||. || |  .
atlekfieelkkeevktvvrvceptydteklekegievld.lafddGavPp.eevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gm

NWRDAVDFIHHRRFSANpNFGFLHQLKVYS
. .|||.|| ..| .|  |   |. |. | 
kyedavefirekrrgai.nskqlkflekyk
subfamily_DSP23_pd Subfamily DSP23 111-166 1.2e-09 32.9 In-house 70-125 (148) alignment 
Range on Protein: 111-166
Range on HMM: 70-125/148.0
IEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLVAFYLISALSINWRDAVDFIHHRR
..| ||..... .|.| | ||| ||  |. |..| ||.    .   .|.  . ..|
vvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr
0048567 (Phosphotyrosine protein) phosphatases II 114-168 7.9e-08 26.8 In-house 63-120 (157) alignment 
Range on Protein: 114-168
Range on HMM: 63-120/157.0
AVRIIHDSRSKEEGVLVHCFLGV---SRSATLVAFYLISALSINWRDAVDFIHHRRFS
. ..... . ..  . ||| .|    .|.|||.. |||  |... ..|....   | .
lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpg
Y_phosphatase Protein-tyrosine phosphatase 56-149 1.9e-07 26.1 Pfam-A 99-194 (235) alignment 
Range on Protein: 56-149
Range on HMM: 99-194/235.0
RTVSQNSElLKEKNITTVINVSDREVVNYKNNQ--KFIKNYRFYAMSDTASA-KFDGIIeEAVRIIHDSR-SKEEGVLVHCFLGVSRSATLVAFYLIS
 ... . .  |||.... ..... |. . |...  . .| . . .  |     . .... . .| .. |. .|.. |.|||  ||.|..|.||  .. 
gdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll.dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
Y_phosphatase Protein-tyrosine phosphatase 56-149 1.9e-07 26.1 In-house 99-194 (235) alignment 
Range on Protein: 56-149
Range on HMM: 99-194/235.0
RTVSQNSElLKEKNITTVINVSDREVVNYKNNQ--KFIKNYRFYAMSDTASA-KFDGIIeEAVRIIHDSR-SKEEGVLVHCFLGVSRSATLVAFYLIS
 ... . .  |||.... ..... |. . |...  . .| . . .  |     . .... . .| .. |. .|.. |.|||  ||.|..|.||  .. 
gdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll.dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
subfamily_PTEN_pd Subfamily PTEN 69-170 2.4e-07 25.9 In-house 60-160 (184) alignment 
Range on Protein: 69-170
Range on HMM: 60-160/184.0
NITTVINV-SDRevvNYkNNQKFIKNYRFYAMSDTASAKFDgIIEEAVRIIHD--SRSKEEGVLVHCFLGVSRSATLVAFYLISALSINWR-DAVDFIHH
.   ..|. |.|   .| ...|| ..   | ..|  ..... ..||.|. |..  ...|.. | |||  |  |. .|.. ||. .| ..   .|... ..
dhykiynlrser...ky.dskkfdgrvavypfdDhnppple.lleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfae

RRFSAN
 |.. .
aRtknk
subfamily_Ptp69D_pd Subfamily Ptp69D 73-148 4.4e-07 24.3 In-house 165-242 (307) alignment 
Range on Protein: 73-148
Range on HMM: 165-242/307.0
VINVSDRE-VVNYKNNQKFIKNYRFYAMSDTASAK-FDGIIEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLVAFYLI
 ..||  .  ..  .... .  |.. .  |.   .   |...   .. .  . ..  ..||| .||.||...||. ..
eldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsl
subfamily_PTPDC1_pd Subfamily PTPDC1 96-168 5.2e-07 24.3 In-house 87-157 (182) alignment 
Range on Protein: 96-168
Range on HMM: 87-157/182.0
FYAMSDTASAKFDGIIeEAVRIIHDSRSKEeGVLVHCFLGVSRSATLVAFYLISALSINWRDAVDFIHHRRFS
 ....|  .|  . |. . |.... . ...  | |||  |  |   |.| ||. | ...  .|.... ..| .
nfgwkDygvasleriL.divkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 72-150 8.4e-07 23.3 In-house 160-234 (307) alignment 
Range on Protein: 72-150
Range on HMM: 160-234/307.0
TVINVSDREVVnYKNNQKFIKNYRFYAMSDTASAKFDgiiEEAVRIIHDSRSKEEGVLVHCFLGVSRSATLVAFYLISA
 .|||.. .|. . .. . |. ...    |    . .     |. ...  | ... |.|||  || || |.||  |.  
dlinvttlkvd.waqksrtiqhlqwenwpdrgvpqin...ltainlleavrydtnpvvvhcsaGvGrsGtivaislvqd
DSPc_SM00195 68-148 1.1e-06 23.5 In-house 136-218 (263) alignment 
Range on Protein: 68-148
Range on HMM: 136-218/263.0
KNITTVINVSDREVVNYK-NNQKFIKNYRFYAMSDTASA-KFDGIIEeAVRIIHDS-RSKEEGVLVHCFLGVSRSATLVAFYLI
..    |.. . |. . . ....... | . .  |     . . ..|  .| .. | ..... ..|||  ||.|..|.|.  .|
ekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle.llravkkskstssgpivVhCsaGvgRtgtfvtidii
PTPc_SM00194 68-148 1.1e-06 23.5 In-house 136-218 (263) alignment 
Range on Protein: 68-148
Range on HMM: 136-218/263.0
KNITTVINVSDREVVNYK-NNQKFIKNYRFYAMSDTASA-KFDGIIEeAVRIIHDS-RSKEEGVLVHCFLGVSRSATLVAFYLI
..    |.. . |. . . ....... | . .  |     . . ..|  .| .. | ..... ..|||  ||.|..|.|.  .|
ekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvle.llravkkskstssgpivVhCsaGvgRtgtfvtidii
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 63-146 1.8e-06 22.1 In-house 151-237 (290) alignment 
Range on Protein: 63-146
Range on HMM: 151-237/290.0
ELLKEKNITTVINvSDREVVNYK--NNQKFIKNYRFYAMSDTA-SAKFDGIIEEAVRIIH-DSRSKEEGVLVHCFLGVSRSATLVAFY
.||.|..... |.    || | .  .... ...|.. .. .|   ..  .|.    ....   .. .. ..|||  .|.|||...| .
kllneetlneyie.rklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaa
subfamily_CDKN3_pd Subfamily CDKN3 105-168 2.7e-06 21.1 In-house 116-176 (202) alignment 
Range on Protein: 105-168
Range on HMM: 116-176/202.0
AKFDGIIEEaVRIihdSRSKEEGVLVHCFLGVSRSATLVAFYLI-SALSINWRDAVDFIHHRRFS
|.   |.|| .||   .  .  . ||||. |. ||. ..|  |.     |...||.| . . . |
asclkilee.lri...nlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgs
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 38-145 3.2e-06 20.8 In-house 135-241 (302) alignment 
Range on Protein: 38-145
Range on HMM: 135-241/302.0
NLSSRKISEILPNLYLSGRTVSQNSEL--LKEKNITTVINVsdrEVVNYKNNQKFIKNYRFYAMSDTASAKFDGIIEEAVRIIHDSRSKEEGVLVHCFLG
.  | |. . |     . .||| . .|  . .|.  .. .|   |. |.| ..|  |     | |           . |. |..   |  . |||||  |
eyysdkvggelkfgrytvktvsvktdleeftdkksfklytv...eiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaG

VSRSATLVAF
| |. |||| 
vGrtGtlvai
subfamily_CDC14_pd Subfamily CDC14 63-163 3.2e-06 21.2 In-house 206-301 (328) alignment 
Range on Protein: 63-163
Range on HMM: 206-301/328.0
ELLKEKNITTVINVSDREVVNYKNNQKFIKNYRFYAMsDtASAKFDGIIEEAVRIIHDSrskEEGVLVHCFLGVSRSATLVAFYLISALSINWRDAVDFI
|  ...|.|||. .  .   . | ... .. .  . . |  |   | |... ..|. ..   | .. |||  |. |  ||.| ||.    ..  .|. ..
eyfrknnvttvvrLnkklYdakkftdaGfdhkDlffi.D.GstPsdaivkkfleiaeka...eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawl

H
 
r
subfamily_DSP11_pd Subfamily DSP11 116-166 5.1e-06 20.5 In-house 107-157 (178) alignment 
Range on Protein: 116-166
Range on HMM: 107-157/178.0
RIIHDSRSKEEGVLVHCFLGVSRSATLVAFYLISALSINWRDAVDFIHHRR
. ....  ... . |||  || |.  |.  |||.  ... .||..  .. |
efleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear
subfamily_RNGTT_pd Subfamily RNGTT 67-166 8.4e-06 19.6 In-house 52-154 (189) alignment 
Range on Protein: 67-166
Range on HMM: 52-154/189.0
EKNITTVINVSDREVVNYKNNQKF--IKNYRFYAMSDTASAKFDGiIEEAVRIIHD--SRSKEEGVLVHCFLGVSRSATLVAFYLISALSINWRDAVDFI
....  ||...  .    |.. .   ||  ..   .  .. . .  ..|  .....  ... || . |||  |  |.  |.. ||.   ... ..||.  
kvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeq.vkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalF

HHRR
 . |
akaR