Gene C33F10.8 in Caenorhabditis elegans

Synonym: CELE_C33F10.8, C33F10.8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf17
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP030_AA protein Get Run
CeleP030_AA_133-410 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 109-412 4.3e-58 192.4 In-house 5-302 (308) alignment 
Range on Protein: 109-412
Range on HMM: 5-302/308.0
AQQELEKTNWKTTTTETEDEDVAGQKYIKFMDQvaFIENGTTLSTFFSNHLMNIAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLadPNIVYYIHANHIM
.. .||.. .. |.. ......  ....|....   ...|     |.    . . .. .. ..  |  ||. ||... | .||||  ..   ||.|....
ldallelllfrdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvd

FD--HLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNvYPMYYPNKPE-TFNNFGQFFVYCKTVTQpktKYGCKEYKFELVVQADNEE
.   .|....| ||.|||.|..||| || .|.|..|| ||.    . .. .. |.|.... .. ..|.|.|... ...   . ... ...||.   |.|.
gyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrek.caqYwplelgggsleygkftvtllseev...lddytvrtleltnlgdges

rRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQAPVVVQCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATV
 | |. .||..|    || | . .|...... |. .. |.|| |  ||. .. .. .| .. .| .. .|..  .....|.|.. . . . ..|  . ..
.rtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyral

MKFIKIR
....| .
leylklk
DSPc_SM00195 157-410 3.7e-57 189.0 In-house 8-263 (263) alignment 
Range on Protein: 157-410
Range on HMM: 8-263/263.0
NHLMN-IAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPN---IVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSAs
.....    .... ... |. ||. |.....|.||||| ...      ||.||.| ... ||.|| ||.||| |..||| || ..||..||.||. .   
kleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen.

NPNVYPMYYPNKPETFNNFGQFFVYCKTVTQPKtkYGCKEYKFELVVQADnEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKS--QAPVVVQCE
. .    |.|.. .. ..||.. | .. |.. |    .. ...||  ... || |.|. |.|  |... || | | ||.|.... |.||  ..|.||.| 
gkekcdrywpeesggketfgkisvklvevekkk..deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs

TGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIK
.||.... .| .| ..  |... .|... .....|.|.. ....| ..|  . .....||
aGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 157-410 3.7e-57 189.0 In-house 8-263 (263) alignment 
Range on Protein: 157-410
Range on HMM: 8-263/263.0
NHLMN-IAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPN---IVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSAs
.....    .... ... |. ||. |.....|.||||| ...      ||.||.| ... ||.|| ||.||| |..||| || ..||..||.||. .   
kleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen.

NPNVYPMYYPNKPETFNNFGQFFVYCKTVTQPKtkYGCKEYKFELVVQADnEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKS--QAPVVVQCE
. .    |.|.. .. ..||.. | .. |.. |    .. ...||  ... || |.|. |.|  |... || | | ||.|.... |.||  ..|.||.| 
gkekcdrywpeesggketfgkisvklvevekkk..deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs

TGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIK
.||.... .| .| ..  |... .|... .....|.|.. ....| ..|  . .....||
aGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
0036941 (Phosphotyrosine protein) phosphatases II 161-413 9.5e-57 187.9 In-house 26-281 (297) alignment 
Range on Protein: 161-413
Range on HMM: 26-281/297.0
NIAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLaDPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSAsNPNVYPMY
 . .. .  ....|  ||. ||... |.||||| |..   ||.|... . .||...| ||.|||.|..||| || .|.|..||.||.  .  . . .. |
lllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel.grekcaqy

YPNKPETFNNFGQFFVYCKTVTQPkTKYGCKEYKFELVVQaDNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKK----SQAPVVVQCETGVNQS
.|.. . . ..|.|.| ...|..  .. ... ...|..   .|.| | |. .||..|  . || | . .|...... |.     |. ||.| |  ||. |
wpleegesltygdftvtllsvevv.llddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

AELVFVDAMCTLLT---RQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIKIRF
. .. .| |. .|    .. .|..  .....|.|.. | ..| ...  . ......| . 
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0040438 (Phosphotyrosine protein) phosphatases II 144-433 9.7e-55 181.4 In-house 17-303 (317) alignment 
Range on Protein: 144-433
Range on HMM: 17-303/317.0
FiengTTLSTFFSNHLMNIAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNI---VYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVE
|    | |. .| . | .. .| .  ..  |  ||. .|... |..|||| ...      ||.|... . .||...| ||.|||.|..||| || .|.|.
f....talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

TIVSLTSSSSASNPNVYPmYYPNkpETFNNFGQFFVYCKTVTQpktKYGCKEYKFELVVQaDNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKK-
.||.||..   .... .. |.|.  ... ..|.|.| .. ...   . |.. ...|..   ...| | |. .||..|.   || | . .|...... .. 
vivmLteleelgrekcaq.Ywpl..getltygdftvtllseee...lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreal

-KSQAPVVVQCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKF---IKIRFSAMPSHYAAQMDSILPAISK
 ... ||.| |  ||. .. .. .. |. .| .  .|...  ....|.|.. |.. . ..   .  ....      . .|.. ... ..  | .|...
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplaldd
Y_phosphatase Protein-tyrosine phosphatase 174-405 2.9e-54 179.4 Pfam-A 1-233 (235) alignment 
Range on Protein: 174-405
Range on HMM: 1-233/235.0
NTFKNQRKDVPCIDDTRVKL-ADPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpNVYPMYYPNKPETFNNFG
|  ||. ||....|.|||||  ...   ||.||...  . ||..| ||.||. |..|||.|| ..||..|| |||    .. . .. |.|.. |.....|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr.ekcaqYwpeeeeesltyg

QFFVYCKtVTQPKTKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKK--SQAPVVVQCETGVNQSAELVFVDAMCTLLT
...| .| . . . . ..  .|.||  .....|.|.|. .|| .|... ||.|.| .|.|..|. |.|  ...||||.| .||.... .| .|...  |.
dikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

RQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATV
.. ||.   . ...|.|.. ....|  .   ....
aeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 174-405 2.9e-54 179.4 In-house 1-233 (235) alignment 
Range on Protein: 174-405
Range on HMM: 1-233/235.0
NTFKNQRKDVPCIDDTRVKL-ADPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpNVYPMYYPNKPETFNNFG
|  ||. ||....|.|||||  ...   ||.||...  . ||..| ||.||. |..|||.|| ..||..|| |||    .. . .. |.|.. |.....|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr.ekcaqYwpeeeeesltyg

QFFVYCKtVTQPKTKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKK--SQAPVVVQCETGVNQSAELVFVDAMCTLLT
...| .| . . . . ..  .|.||  .....|.|.|. .|| .|... ||.|.| .|.|..|. |.|  ...||||.| .||.... .| .|...  |.
dikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

RQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATV
.. ||.   . ...|.|.. ....|  .   ....
aeeevdvlqivkelRkqRpgmvqsleqYiflykai
0047943 (Phosphotyrosine protein) phosphatases II 163-408 8.1e-52 171.7 In-house 27-271 (273) alignment 
Range on Protein: 163-408
Range on HMM: 27-271/273.0
APTSRSDAFHGNTFKNQRKDVPCIDDTRVKLaDPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYPmYYP
  | .  ..  |  ||. ||... |..|||| ...   ||.|... . .||...| ||.|||.|..||| || .|.|..||.||.  . .... .. |.|
lltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaq.Ywp

NKPET-FNNFGQFFVYCKTVTQpktKYGCKEYKFELVVQADNEeRRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGK----KKSQAPVVVQCETGVNQSA
.. .. . ..|.|.|... ...   | ... ...||.   ..|  | |. .||..|  . ||.| . .|...... |     .|. |||| |  ||. ..
leggelsltygkftvtllseet...kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtg

ELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKF
 .. .| .. .| .  .|... .....|||.  . . . ...  . .....
tfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0046845 (Phosphotyrosine protein) phosphatases II 164-413 1.6e-51 170.7 In-house 18-278 (284) alignment 
Range on Protein: 164-413
Range on HMM: 18-278/284.0
PTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNI----VYYIHANHIMFD-----HLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNP
 . .  ..  |  ||. ||... |..||||  ..       ||.|... .      . ||..| ||.|||.|..||| || .|.|..||.||.  . .. 
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

NVYPmYYPNKpETFNNFGQFFVYCKTVTQpktKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKK----KSQAPVVVQCE
  .. |.|.. ... ..|.|.|... ...   | ... ...||.    ..| | |. .||..|  . ||.|.. .|...... .     ... |.|| | 
kcaq.Ywple.gevltygdftvtllseev...kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs

TGVNQSAELVFVDAMCTLLTRQV---EVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIKIRF
 ||. .. .. .| ....| ..    .|..  .....|.|.  . ..| ...  . ... ..| ..
aGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 134-409 6.6e-51 168.8 In-house 9-286 (288) alignment 
Range on Protein: 134-409
Range on HMM: 9-286/288.0
KYIKFMDQVAFIENGTTLSTFFSNHLMNIAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPN---IVYYIHANHIMFDHLKKTYITTQHPLPGTLNDF
...|.. ..    . . |  |     ... .| .. ..  |  ||. .|... |..|||| ...      ||.|..| . .||...| ||.|||.|..||
ellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedF

WAMVADQKVETIVSLTSSSSASNPNvYPMYYPNkpETFNNFGQFFVYCKTVTQpktKYGCKEYKFELVVQA---DNEERRSVRLYHYPHWTKNMVPASSK
| || .|.|..||.||.    .. . .. |.|.  ... ..|...|... ...   . ... ...|..       ..| | |. .||..|  . || | .
WrmvweqnvrvIvmltklvelgrek.caqYwpl..ggsltygditvtllseev...lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

VVLNLVKKIGKK--KSQAPVVVQCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFI
 .|...... |.  ... |||| |  ||. .. .. .| .. .| .. .|..  .....|.|.  . . . ...  . ... ..
llldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 158-403 9.6e-51 168.4 In-house 40-282 (297) alignment 
Range on Protein: 158-403
Range on HMM: 40-282/297.0
HLMNIAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNI----VYYIHANHIMFDHL-KKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSAS
.|... |  .  ..  |  ||. ||... |..|||| ...       ||.|... . .| ....| ||.|||.|..||| || .|.|..||.||.    .
ellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelg

NpnVYPMYYPNKPEtfnNFGQFFVYCKTVTQpktKYGCKEYKFELVVqadNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKK----SQAPVVVQ
.   .. |.|.. .   ..|.|.|....|..   . |.. ...|..    |.| | |. ..|..|  . || |....|...... .      .. ||.| 
r..kcaqywpeegg...tygdftvtllkveh...ldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVH

CETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKaLAMTQLLHFLHSIA
|  ||. .. ..  . |...| .  .|...  ....|.|.   . | ..... . 
CsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR.pgavqtpsqyrfly
0043336 (Phosphotyrosine protein) phosphatases II 133-400 3.2e-50 166.5 In-house 5-267 (278) alignment 
Range on Protein: 133-400
Range on HMM: 5-267/278.0
QKYIKFMDQVAFIENGTTLSTFFSNHLMNIaPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNI---VYYIHANHIMFDHLKKTYITTQHPLPGTLND
 ...|.. .. . .. ..|  |.. . ... .| .  ..  |  ||. ||... | .|||| . .      ||.|... . . ....| ||.|||.|..|
kdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWAMVADQKVETIVSLTSSSSASNPNVYPmYYPnkpETFNNFGQFFVYCKTVTQpktKYGCKEYKFELVVQADNEErRSVRLYHYPHWTKNMVPASSKVV
|| || ...|.|||.||.    .... .. |.|   ... ..|.|.|... ...   . ... ...|..   |.|. | |. |||..|  . || | . .
FwrmvwelgvttivmLtelvelgrvkcaq.Ywp...ggsltygdftvtllkeeh...lddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsll

LNLVKKIGKK--KSQAPVVVQCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKaLAMTQLLHFLH
|...|.. ..  .|. ||.| |  ||. .. .. .. ....| .  .|...  ....|.|.   . | . ...
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR.pgavqtpsqyr
0045450 (Phosphotyrosine protein) phosphatases II 158-399 3.8e-50 166.7 In-house 35-293 (307) alignment 
Range on Protein: 158-399
Range on HMM: 35-293/307.0
HLMNI----APTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADP----NIVYYIHANHI--------MFDHLKKTYITTQHPLPGTLNDFWAMVADQKVET
.|...      . .. ..  |  ||. ||... |.||||| ..    .   ||.|...         . .||...| ||.|||.|..||| |. .|.|..
kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtv

IVSLTSSSSAsNPNVYPMYYPNKpETFNNFGQFFVYCKTVTQpktKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKK--
||.||..    . . ...|.|.. ... ..|.|.|... ...   . |.. ...|.     ..| | |. .||..|    || | . .|...... |   
ivmltelvel.grekcaqywPde.geeltygnftvtllseeh...ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkale

--KSQAPVVVQCETGVNQSAELVFVDAMCTLLTRQVE---VNFDVLFRQMRSQKaLAMTQLLHFL
  ... ||.| |  ||. .. ..  . |...| .. .   |...  ....|.|.   . | ....
elpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR.pgavqnpeqy
0045098 (Phosphotyrosine protein) phosphatases II 149-403 8.4e-47 155.2 In-house 8-265 (278) alignment 
Range on Protein: 149-403
Range on HMM: 8-265/278.0
TTLSTFFSNHLMNIAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKladpnivYYIHANHIMFDhlKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSS
 .|. |. ..|..|  .     . ||  ||  ||....| .|||        ||.|..|..   .|..| ||.||| |..||| |. ......||.||. 
dlllefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltel

SSASNPnVYPMYYPNkpETFNNFGQFFVYCKTVTQPKTKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASS--KVVLNLVKKIGKKK------
   ..   ...|.|.  . . ..|.|.|... ... .. . .. .   | |.  . | | |. .||..|  . || ..  | .|.|.. | .        
velgre.kcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------SQAPVVVQCETGVNQSAELVFVDAMCTLLtrQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIA
         |. ||.| |  ||. .. || .. |..||  .  |...  ....|||.   . | |.... . 
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrfly
0042113 (Phosphotyrosine protein) phosphatases II 170-399 5.5e-45 149.1 In-house 5-232 (245) alignment 
Range on Protein: 170-399
Range on HMM: 5-232/245.0
AFHGNTFKNQRKDVPCIDDTRVKLADPNIV---YYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYPmYYPNkpE
..  |  ||. .|... |.||||| ...      ||.|... ... ....| ||.|||.|..||| |. .....|||.||.    . .. .. |.|.  .
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaq.ywpl..g

TFNNFGQFFVYCKTVTQpktKYGCKEYKFELVVqADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGK---KKSQAPVVVQCETGVNQSAELVFVD
.. ..|.|.|.......   . ... ...|..    . | | |. ||| .|  . || ... .|.... . |   ..|. ||.| |  ||. .. .. ..
esltygdftvtllseeh...lddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

AMCTLLTRQVEVNFDVLFRQMRSQKaLAMTQLLHFL
 |...| .  .|...  ....|||.   . | ....
lmleqlekelgvsleeavkelrsqR.pgavqtpsqy
0040439 (Phosphotyrosine protein) phosphatases II 169-401 6e-45 149.2 In-house 6-237 (249) alignment 
Range on Protein: 169-401
Range on HMM: 6-237/249.0
DAFHGNTFKNQRKDVPCIDDTRVKLAD---PNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYPmYYPNkp
  .  |  ||. .|... | .|||| .    .   ||.|..| . . |...| ||.|||.|..||| |. ......||.|||     . . .. |.|.  
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaq.ywpl..

ETFNNFGQFFVYCKTVTQpktKYGCKEYKFELVVQaDNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKK----SQAPVVVQCETGVNQSAELVF
... ..|.|.| .. |..   | ... ...||.    . | | |. ..|..|    || | . .|...... |      .. ||.| |  ||. .. .. 
ggsleygdftvtllsvev...kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

VDAMCTLLTRQVEVNFDVLFRQMRSQKALaMTQLLHFLHS
 . |...| .  .|...  ....|||.   . | ....  
aylmleqlekelgvdleeavkllrsqRpg.avqnpeqyrf
subfamily_Ptp69D_pd Subfamily Ptp69D 166-398 4.9e-38 126.0 In-house 40-275 (307) alignment 
Range on Protein: 166-398
Range on HMM: 40-275/307.0
SRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNI---VYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVyPMYYP
..  . . |..||. .|.   |.|||||.  |      || |..|   . ||..|. | |. .|..||| |.|.|.|..|| |.  .  .. .. . |.|
tkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkc.akYWp

NKpeTFNNFGQFFVYCKTVtQPKTKYGCKEYKFELVV--QADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKI--GKKKSQAPVVVQCETGVNQSAE
.   .  ..|.  | .    . ...|  .|...  .    .. |..| |  |||  |   .|| ... .|.|....   .|....|.|| | .||..|. 
ie..devqygdilvklvse.ekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgi

LVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHF
.| .| .   |    .|.     ...|||. | ...|  .
fvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqY
subfamily_PTPN3_pd Subfamily PTPN3 173-399 1.6e-37 124.0 In-house 40-265 (280) alignment 
Range on Protein: 173-399
Range on HMM: 40-265/280.0
GNTFKNQRKDVPCIDDTRVKLADPNIvYYIHANHIMFDHLK----KTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNKPETF
 |  ||. .|.   |.||||| . .   || ||.. ..       . ||.|| ||. | .||| || .||...|| ||.         .  |.|.. ...
enlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh.qyWPetedel

nNFGQFFVYCKTVtQPKTKYGCKEykFELVvQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKK--SQAPVVVQCETGVNQSAELVFVDAMC
 ..|.| |.|.   . ...|  .|  . |  .....|.|..    |  |. . || .|. .|..|... |..  .. |||| | .|....  |....   
.eygefsvkceke.detksyvlre..lvlk.dketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletal

TLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFL
.|. .. .|.   . |.|| |.|  . .   . 
alieaaepvypldivrtmrdqramlvqtasqyk
0037934 (Phosphotyrosine protein) phosphatases II 172-403 4.2e-37 123.4 In-house 8-235 (243) alignment 
Range on Protein: 172-403
Range on HMM: 8-235/243.0
HGNTFKNQRKDVPCIDDTRVKLadPNiVYYIHANHIMFDhlkKTYITTQHPLPGTLND----FWAMVADQKVETIVSLTSSSSASNPNVyPMYYPnkpET
  |  ||. .|... |..||||  ..   ||.||.|.     ...| ||.|||.|..|    || |. ......||.||.    .  .. ..|.|   ..
penlsknrysdilpydhsrvkl..eg.sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekc.aqywp...ge

FnNFGQFFVYCKTVTQpktKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIG----------KKKSQAPVVVQCETGVNQSA
. ..|.|.| .. ...   . ... ....|.    ... | |. |||  |  . || | . .|......           . .|. ||.| |  ||. ..
v.tygdftvtllseeh...lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

ELVFVDAMCTLLtrqvEVNFDVLFRQMRSQKALAMTQLLHFLHSIA
 |.  . |..||    .|...  ....|.|.   . | ..... . 
tliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrfly
subfamily_PTPRD_pd Subfamily PTPRD 149-392 2.7e-36 120.4 In-house 23-264 (564) alignment 
Range on Protein: 149-392
Range on HMM: 23-264/564.0
TTLSTFFSNHLMNIAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNI---VYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSL
..... . .  ..   | .. . . |  ||  ...   | .||.|   .      || |..|   . .|.|| ||.||. |..||| || .|...||| |
lkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVml

TSSSSASNpNVYPMYYPNKpEtFNNFGQFFVYCKTvtqPKTKYGCKEYKFELvVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKK--KSQA
|. .  .. . . .|.|.| .   ..|.. |  .     ...      .|.|  .....| | || .|. .|  . || | . .|.|..|. .   . . 
tkleEkgk.vkchkYWPek.g.tetygeltVtlee...eeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdag

PVVVQCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAM
|.||.|  ||  .   . .|||   .. .  |.     ...|.|.    
PivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamV
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 165-394 1.3e-33 111.4 In-house 37-264 (318) alignment 
Range on Protein: 165-394
Range on HMM: 37-264/318.0
TSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNI---VYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVyPMYY
||       | .||.  ..   |.||||| . .      || ||.|   . ||.|| .| ||| |..||| || .|.  .|| ||  . ..   |   |.
tslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakv.hryW

PNKPEtfNNFGQFFVYCKTVTQpKTKYGCKEYKfelVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKK---SQAPVVVQCETGVNQSAE
|.|    ...|.  |  |  ..  ..|  .|.|   | . ..|| | || |||  |. . ||.|.  .|.||... | .   .. |.|| | .|| .   
Pskgs..rsygklvvelkeeve.lsdyvlrefk...vtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGv

LVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALaMTQ
 . ||..   .  .  |.     .|.|.|. | | |
fiavdillerikaealvDvfqtvkqlreqrnl.mvq
subfamily_PTPRG_pd Subfamily PTPRG 172-415 1.6e-33 110.7 In-house 45-293 (563) alignment 
Range on Protein: 172-415
Range on HMM: 45-293/563.0
HGNTFKNQRKDVPCIDDTRVKLAD-PN---IVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpNVYPMYYPNkpET
. |  ||   ..  .| .||||.. |.      || ||.|.  . .| .|.||.||. |..||| |. .|.|..|| .|      . .  ..|.|.  ..
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergr.rkcdvYWPk..de

FNNFGQFFVYCKTvTQPKTKYGCKEYKFEL---VVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQ--APVVVQCETGVNQSAELVFV
  ..|.. |  .. .. .. |  .. . .      . . .. . || |||..|    || .|  ||. |||  . . .   |.|| |..|| ..  .. .
setygalqvtlie.eevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivl

DAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIKIRFSA
|..   . ..  ||   . ...|.|.   ...   ...   .... |. .   
dtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete
subfamily_PTPRB_pd Subfamily PTPRB 165-409 3.5e-33 109.9 In-house 42-285 (293) alignment 
Range on Protein: 165-409
Range on HMM: 42-285/293.0
TSRSDAFHGNTFKNQRKDVPCIDDTRVKL---ADPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVyPMYY
.  ..  . |. ||. ...   | .||||   .| .   || ||.|   . .. .|.|| |||.|..||| || ..|...|| ||             |.
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkC.eeYW

PNKPETFnNFGQFFVYCKTvTQPKTKYGCKEYKFELvvqadNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKK----KSQAPVVVQCETGVNQSA
|.. |.  ..|.  |  .. .. .... ..|.| |      ..|.|.|| ||.  |.   || ..| .|..|... ..    .|..|.|| |  ||  . 
Padeepv.lyGdikvtlva.eeeledwvirelkiek.....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtG

ELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFI
 .. .| .   ....  |.   .  ..|....| .    ....   .|....
tfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 172-408 5.6e-33 109.5 In-house 54-289 (298) alignment 
Range on Protein: 172-408
Range on HMM: 54-289/298.0
HGNTFKNQRKDVPCIDDTRVKLAD---PNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpNVYPMYYPN-KPET
. |  ||   |.  .| .|| | .    ..  || | ..   . ....|.||.||. |..||| || .....||| ||.     .   |. |.|. . ||
penkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldk.tkyhkywPdegket

fnnFGQFFVyckTVTQPKTKYGCKEYKFElVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQA---PVVVQCETGVNQSAELVFVDA
   .|.. |   .. . ...      |.. | ....|..|.||  |. .|. . ||. .. ||.|..|. ....||   ||.|||  ||. |   . .|.
...ygeitv...sllskeefadlivrklk.vskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaids

MCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKF
.   . ..  |      . .| ... |..   .. .    |...
vlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_PTPN23_pd Subfamily PTPN23 174-406 5.9e-33 108.9 In-house 43-277 (288) alignment 
Range on Protein: 174-406
Range on HMM: 43-277/288.0
NTFKNQRKDVPCIDDTRVKLAdPNIVYYIHANHIM-FDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNKPETFNNFG
.. ||. .|.   | .||||   .   || | ..        ..|.|| ||..|||||| || .||...|| |.| .   .|.|   |.|.. .  ..||
yseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvd.rYwPedkgetvkfg

QFFVYCKTVTQPKTkygCKEYKFELVVQaDNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGK------KKSQAPVVVQCETGVNQSAELVFVDAMC
.. | .| |.. .|   . |....| .. |... .||.. ..  |..  |||| ...|...... .      .||..|.||.| .||. .  .  | |  
dlsvtlksvretet...hvervlkletl.dadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

-TLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVM
  | ...  ..   .....| |.   . .  .. .|   |.
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 169-400 6.4e-33 109.2 In-house 41-276 (305) alignment 
Range on Protein: 169-400
Range on HMM: 41-276/305.0
DAFHGNTFKNQRKDVPCIDDTRVKLADPNIVY---YIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpNVYPMYYPNKP
.  . |. ||. |..   || |..|.  . .    || |...   . ||.||..| ||. |..||| .. . ||.||| ||      . .   .|.|.. 
gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggk.dkCrqYWpesk

ETFNNFGQFFVyckTVTQPKTKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQA---PVVVQCETGVNQSAELVFV
   ..||.| |   .... ||  .  | |... .. ...| |.|  |.   |  . || ..  .|.|.|.. |....    |..| |  ||  .   . |
tekkefgefsv...elksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiav

DAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFL--H
| .   | .  .|..  . .|.||..  ....| ..   |
dialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflh
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 171-407 1.1e-32 108.3 In-house 44-277 (288) alignment 
Range on Protein: 171-407
Range on HMM: 44-277/288.0
FHGNTFKNQRKDVPCIDDTRVKLAD---PNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNvYPMYYPNKpET
   |  ||. ...  .| .|||| .    .   || |..|  .. ||.||.|| ||. |.|||| .| ..|..||| ||.     . .    |.|.. ..
lavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktk.CeeYWPda.dk

FNNFGQFFVYCKTVTQpKTKYGCKeyKFELVvqaDNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQA--PVVVQCETGVNQSAELVFVDAM
 .|.|.. |  . . . ....  .  |..|.    ..... .  |.|  |. . ||.|.. .|.|....   ...   |..|.|  || ..   . .||.
pknyGsvtvtlveske.ledfvlr..kllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdal

CTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMK
   . ..  ..      ..| |.|| . .| .. .   ....
idaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPN6_pd Subfamily PTPN6 137-389 1.6e-31 104.5 In-house 21-277 (306) alignment 
Range on Protein: 137-389
Range on HMM: 21-277/306.0
KFMDQVAFIENGTTLSTFFSNHLMNIAPTSRSDAFHGNTFKNQrkdVPCiDDTRVKLADPNIVY--YIHANHIM--FDHLKKTYITTQHPLPGTLNDFWA
. ...  | |.  .|..  ...|..   ... .  . | .||    .|  |.|||.|..|...   || || |.  .   .|.||.||  |. |..||| 
eslekagfeeefeelqqeeakkllsrkegakpenkeknrykni...lPf.DhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr

MVADQKVETIVSLTSSSSASNpNVYPMYYPNKPETFNnFGQFFVYCKTVtQPKTKYGCKEykFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNL
|| ... . || .|     .. .    |.|.. |. . .|.  | . .  . ...|  .|  . .  . ...| |.|. ||.  |  . ||.. ..||..
mvwqensrvivmttkevErgk.ekCarYWPdeeekee.yGkisvtnvse.ksladYilRe..lsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdf

VKKIGKKKSQ------APVVVQCETGVNQSAELVFVDAMCTLLTRQ-VEVNFDV--LFRQMRSQKA
.... .|...       |.|| |  |.     .. .|..  |.... .....|.  | ...|.|. 
ledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrs
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 174-403 4.2e-31 103.0 In-house 9-236 (250) alignment 
Range on Protein: 174-403
Range on HMM: 9-236/250.0
NTFKNQRKDVPCIDDTRVKLADPN---IVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPnvYPMYYP-NKPEtfn
|  ||.  |.  .| .|| |   .   .  || | ..   . .|..|.||.||. |..||| || ..|..||| ||. .   .   |. |.| .|.|   
nkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt..yhqywPvekae...

NFGQFFVYCKTvTQPKTKYGCKEYKfelVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQ---APVVVQCETGVNQSAELVFVDAMC
..|.  |  .  .. .. |  ...|   . .| ....| || .|.  |    ||.  . ||.|.||. ... |   |||.||| .|| .|   . .||. 
kyGdvtvslls.keefadytkrklk...lskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

TLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIA
  | ..  |.   . ...| ..  |.. |  .     
erlkkekvvdvfkvikvlrkdrphavesleqyvfvye
subfamily_PTPN12_pd Subfamily PTPN12 172-394 5.8e-31 102.5 In-house 38-261 (290) alignment 
Range on Protein: 172-394
Range on HMM: 38-261/290.0
HGNTFKNQRKDVPCIDDTRVKLADPNIVY---YIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpNVYPMYYPNKPETF
. |. ||. ||.   | .||.|   . .    || ||.|   . |..|| .| ||| ||.||| |. ...|| .| .         .    |.|.. |. 
eenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk.kkCerYWpeegeee

NNFGQFFVYCKTVTQPKTKYGCKEykfeLVVQADnEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGK--KKSQAPVVVQCETGVNQSAELVFVDAMC
 .||.| | ...  . .  .  .     | |.|. .|.|.|. .|| .|    ||.| | .|.|.... .  ....||.|| |  || .   .. .| . 
lefgefevtleeekavdddflirt....Lkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvr

TLLTRQVE-VNFDV--LFRQMRSQKAlAMTQ
.|| ..    ..||  | ...| |.| |. |
ellkaekipeeldvfdlvlelrkqra.alvq
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 162-405 8.9e-31 102.0 In-house 29-272 (281) alignment 
Range on Protein: 162-405
Range on HMM: 29-272/281.0
IAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKL---ADPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYp
.  |...   . |. ||. ...   | ||||.    . .   || ||..   . .| ||.|| |.| .|..|| || .|||..|| .|    |..   . 
vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkCh.

MYYPnKPETFNNFGQFFVYCKTVtQPKTKYGCKeyKFELvvQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKI---GKKKSQAPVVVQCETGVNQ
 |.|  ...  ..|.. |  ..  . |..| ..  ||.|  .... | |.|.  .|  |  . |||..| .|.  |..    .||..||.|. | .|| .
rYWP.ddnselkygdvtvkstae.eekatyier..kfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGr

SAELVFVDAMCTLLTRQ-VEVNFDVLFRQMRSQKALAMTQLLHFLHSIATV
.   . .| ..  ....  |.. . . ...| .. | .  .. . .   .|
tGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykav
subfamily_PTPN13_pd Subfamily PTPN13 159-394 6.1e-30 99.4 In-house 20-253 (273) alignment 
Range on Protein: 159-394
Range on HMM: 20-253/273.0
LMNIAPTSRSDAFH--GNTFKNQRKDVPCIDDTRVKLADPNIvyYIHANHIMFD--HLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNP
| .. |. ...  .   |. ||. ..|  .|.||||| |     || |..|     . . .|| .| ||| | .||| || .||.| |. .|.     . 
lrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkv

NVYpMYYPNKPETFNNFGQ-FFVYCKTVTQpKTKYGCKEYKfelVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKS-QAPVVVQCETG
     |.|.. .      . . |    |.. .  .  .. .   | . . .| | |   .. .|    ||.|.. .|..|... . .. ..|.|| | .|
kch.rywPesknkklkvsnrlevellkvqk.ldgfvvrala...vkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaG

VNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKAlAMTQ
. .|  |. .|..  |. |. |..   . |..| |.  .. |
iGrsGtlitidvvlglierdkefdvkeivrklreqrq.gvvq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 135-399 1.2e-29 97.8 In-house 14-273 (290) alignment 
Range on Protein: 135-399
Range on HMM: 14-273/290.0
YIKFMDQVAFiENGTTLSTFFSNHLMNIAPTSR--SDAFHGNT--FKNQRKDVPCIDDTRVKLADPNIVYYIHANHImfDHLKKTYITTQHPLPGTLNDF
. ||  .|.   |   |.  . ..|.   |.     . |  ||   ||. |||.| | ||| | |     |.|||..  . || ..| || .|  |  |.
fekfasdvvk.knvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyv..kGlkamfiltqGalkdtvidi

WAMVADQKVETIVSLTSSSSASNPNVYPmYYPNKPETFNNFGQFFVYCKTVTQPKTKYgckEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVL
| || ..|| .|| |       ..   . |||.|      ||.. | |   ... ..      |   | . |.     .. ..   |  . |. |.  .|
wrmvlqekvaaivmlceliedGkakceq.yypekeGevltfGeitvlcseeddkdani...ikktlsvrdkdsGkehklkhlkikswpdksvalstlall

NLVKKIgkKKSQAPVVVQCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFL
 ... .  .|   |||| | .|. ..  .| ...   .|.   |..   | | .|  .. ..   . .|
rtlril..rkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 174-409 8.9e-29 95.2 In-house 48-287 (305) alignment 
Range on Protein: 174-409
Range on HMM: 48-287/305.0
NTFKNQRKDVPCIDDTRVKLADPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNKPET---FNN
.. ||. ||| |.|. ||||  |    |||||..      | .| || ||  |  ||| |  ..|||.|  |           .  |.. | .    |..
eagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcl.eyfaskdkdvlefee

FGQ-FFVYCKTVTQPKTKY--GCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIgkKKSQAPVVVQCETGVNQSAELVFVDAMCT
 ||   | ... .. | .     |  . .||..   |. | |  ||.  |    |||.   .|.|..|   . |. |.|| | .|. ..  .|... .. 
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka..rpskgpivvhcsagigrtgsvvmleyild

-LLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFI
 ||. |.  . | .....| |.  ..     .|     .....
qllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 169-409 1.1e-28 95.3 In-house 43-283 (319) alignment 
Range on Protein: 169-409
Range on HMM: 43-283/319.0
DAFHGNTFKNQRKDVPCIDDTRVKLAD---PNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNkp
   . |  ||. ...  .| |||.|..    .   || |..|   . .. .| || ||  |..||| || .... ..| ||  .   . ..   |.|.  
askeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklk.kywpe..

ETFNNFGQFFVyckTVTQPKTKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQ---APVVVQCETGVNQSAELVFV
|.|...|.. |   |. . . . .    |..|  .... | |.|  ..| .|. . || ... .|.|.|.| | ...    |.|| |  ||      . .
enfeeyGrliv...tleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivl

DAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFI
|||   . ..  ..     ...| |. . . .   .     ......
damlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_PTPN1_pd Subfamily PTPN1 169-388 9e-28 91.8 In-house 27-250 (290) alignment 
Range on Protein: 169-388
Range on HMM: 27-250/290.0
DAFHGNTFKNQRKDVPCIDDTRVKLADPNIvYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNKPE-T
  .. |  .|. .||   | .|.|| . .   || |. . ....|. || || ||| | . || || .||  ..| |      ..   .  |.|.. |  
aklpenrnlnryrdvspydhsrikleradn.dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca.qywPqgeeek

FNNFGQFFVYCKTVTQPKTK-YGCKEYKFElvvQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKK----KSQAPVVVQCETGVNQSAELVFV
   . .  .  | ... ... |  . ...|   .   .| |..  .||  |.   || |    |... |. .     . . |.|. | .|. .|  ...|
ellledtklkvkliseerksyytvrllele...nlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclv

DAMCTLLTRQVE---VNFDVLFRQMRSQK
|..  |. .. .   |.    . ..|...
dtclvliekkddlssvdikkvllelrkyr
subfamily_PTPRK_pd Subfamily PTPRK 173-394 1.2e-27 91.5 In-house 42-261 (314) alignment 
Range on Protein: 173-394
Range on HMM: 42-261/314.0
GNTFKNQRKDVPCIDDTRVKLADP--N-IVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNvYPMYYPNKPETfn
 |  ||. .|.   | .||.|     .    || |. |   .  . .| ||.||. |..||| .| |..  .|| ||   . .. .    |.|.. |.  
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvk.ClkyWPedtev..

nFGQFFVYCKTvTQPKTKYGCKEYKFELVvQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKK--SQAPVVVQCETGVNQSAELVFVDAMCT
 .|.. | .   |......  . .. | . .   ||.| || ...  |..  || | . .|.||... |..  .. ..|| | .|  ..   . .| .. 
.ygdikvelve.tellaelvvrifrvekl.argqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivld

LLTRQVEVNFDVLFRQMRSQKAlAMTQ
.. |.  |.     ...||.|   | .
mieregvvdvfnavktlrsrkv.nmve
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 173-407 1.3e-27 92.0 In-house 24-253 (284) alignment 
Range on Protein: 173-407
Range on HMM: 24-253/284.0
GNTFKNQRKDVPCIDDTRVKLAD---PNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTssssasnPNVYPMYYPNKPEtfN
 |  ||.  ..   | ..|||      .   || | .|     |. ||.|| ||. ||.||| |. .... ||| ||        .    |.|.| .   
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.......kdkcsqywplkiv..i

NFGQFFVYCKTVTQPKTkYGCKEykFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKK----IGKKKSQAPVVVQCETGVNQSAELVFVDAM
. ..| |  ..|.. .  |  ..  .||  .. ... |..| .|.  | .  || ..  .. ||||      |.. .|..|| | .|| ..   . .|..
keerfkvkvdsveesee.yvvrd..ielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvl

CTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMK
   . ..  |.   . |..| |.   . .|  .    .....
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN9_pd Subfamily PTPN9 161-395 1.5e-27 91.4 In-house 29-276 (297) alignment 
Range on Protein: 161-395
Range on HMM: 29-276/297.0
NIAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLA---DPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVy
... |      ..|  ||. .|| |.|.|||.||   . .   ||.||..   . ||..|.|| ||. | .||| || .|.| .||  |           
pveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkc.

PMYYPNKPETFNNFGQFFVYCKTvTQPKTKYGCKeyKFElVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKS---------------Q
  |.|.. |. ..||.. |     .. . .|  .  ..| . ....|| |.|  . .  |    || |.. .|....|. .|..               .
gqyWpleeessaefgdlsvsnve.veeeedykvr..vle.iknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsg

APVVVQCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQL
 |.|| | .|. ..  .. .|   . | ..  |.     ...|.|.| ..   
PPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtp
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 172-407 2.5e-27 91.0 In-house 59-289 (319) alignment 
Range on Protein: 172-407
Range on HMM: 59-289/319.0
HGNTFKNQRKDVPCIDDTRVKLAD---PNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTssssasnPNVYPMYYPNKPEtf
  |  ||.  ..   | ..|||      .   || | ..     |. ||..| ||. ||.||| |. .... ||| ||        .    |.|.| .  
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.......kdkcsqywplkiv..

NNFGQFFVYCKTVTQPKTkYGCKEykFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKK----IGKKKSQAPVVVQCETGVNQSAELVFVDA
 . ..| |  ..|.. .  |  ..  .||  .. ... |... .|.  | .  || ..  .. ||||      |.. .|..|| | .|| ..   . .|.
ikeerfkvkvdsveetae.yvvrd..ielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldv

MCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMK
.   . ..  |.   . |..| |.   . .|  .    .....
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 178-412 2.8e-27 90.4 In-house 24-267 (270) alignment 
Range on Protein: 178-412
Range on HMM: 24-267/270.0
NQRKDVPCIDDTRVKLAD---PNIVYYIHANHIM-FDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSsASNPNVYPMYYPNKPETFNNFGQ
|  .|.     |||.|..    ..  || ||..  ||. ||.||... ||| ||..|| |. ..||..|| .|      . .   .|.|..|..  .. .
nRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgle.EkgrkkCerYWpaepkekvkled

FFVYCKTVTQPKTKYgCKEYkfELVVQADNEERRSVrLYHYPHWTKNMVPASSK------VVLNLVKK---IGKKKSQA-PVVVQCETGVNQSAELVFVD
 ..   .... |..        .| .. . |||| |  ..| .|  . || ..        .|.....     |....| |..| |  ||. .  |. .|
gkikvlalseekeeg.yilt..rlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

AMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIKIR
 .. || ....|.   . ...| ..   . .  .. .  ..|..... |
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 163-408 1.4e-26 88.1 In-house 24-269 (285) alignment 
Range on Protein: 163-408
Range on HMM: 24-269/285.0
APTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNIvYYIHANHI-MFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASnPNVYPMYY
 |     |.. |   |.  || ||..||| | . .   ||||. . |  . . |||||| ||| ||.||| |. ..|.  .. | .       .   .||
ppnctytayeanpdlnryadvrcieetrvvlknhdr.dyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfegg.vekcalyy

PNKPETFNNFGQFFVyckTVTQPKTKYGCKEYKFELVVQaDNEERRSVRLY----HYPHWTKNMVPASSKVVLNLVKKIGKKK-SQAPVVVQCETGVNQS
|.|     .||.. .   |.|. | .  .      | |  . |.  |  ||    . | |  .. |  .. ...| | . | .  . |..|.| .|| ..
peklgevvkfgkyei...tlteckeeaiagtilnaltvi.ntedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrt

AELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKF
| .| .|     .  . ....  . |.||. .  |.   ..||     .|..
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 177-424 2e-26 87.5 In-house 53-296 (301) alignment 
Range on Protein: 177-424
Range on HMM: 53-296/301.0
KNQRKDVPCIDDTRVKLADPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSaSNPNVYPMYYPNKPETFNNFGQFFV
|.... |||  .| |.. .      |||| |  .   . .|.|| ||. | .|||||.   .||.|| |.      . ..   |.| |..   . |.| .
khryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkve.kleekceeylpvkisekldigrfki

YCKTVTQPKtKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIgkKKSQAPVVVQCETGVNQSAELVFVDAMCTLLTRQVEVN
  |.  .   .   .. ..|..  ... . |.|  | | .||.. || |   . .|.. .  |||. |.||.| .|. .|  ..  . .   .  . ...
kiknkelil.nkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelv..kksekPivvhcsaGiGrsvafigteylareveadptie

FDVLFRQMRSQKALA--MTQLLHFLhSIATVMKFIKIRFSAMpSHYAAQM
.   ....| ..  .  ... |...  . || ..|| .   |  .|  |.
ltealkhlrehrwngvqtnsqlywm.tlGtvyrlikeygfdm.kiyeeql
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 160-389 3.1e-26 87.1 In-house 16-248 (274) alignment 
Range on Protein: 160-389
Range on HMM: 16-248/274.0
MNIapTSRSDAFHGNTFKNQRKDVPCIDDTRVKL----ADPNIVYYIHANHIM-FDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSAsNP
.|   . .     |.. ||. |..   . .|| |    .. .   || ||.|  .|. .|.|. || ||| |..||| |.  ..|. || ||  . | | 
lnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkea.ne

NVYPMYYPNKPET--FNNFGQFFvycktvTQPKTKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKS-----QAPVVV
.   .|.|.. ..   ...|..        . . .  ...|. . .|    |..|||  | |..|  . .| . . .|.||... ....      |||||
qkCavyfPdaedyeiserygdve......ikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvv

QCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKA
 |  |. .    . ..  .  | ..  |.   .  ..| .. 
hCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrG
subfamily_egg_pd Subfamily egg 155-406 4.2e-26 86.3 In-house 22-267 (307) alignment 
Range on Protein: 155-406
Range on HMM: 22-267/307.0
FSNHLMNIAPTSRSdAFHGNTFKNQRKDVPCIDDTRVKLADPNIVY---YIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSsssA
 .... .  .  .. |   |  | . | |.| | .||||  ..  |   .||||..  . |  ..| .| ||  | .||| ||  ..|. || |||   .
vleesvdeisltta.asdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmlts...r

SNPNVYPMYYPNKPETFNNF--GQFFVYCKTVTQ-PKTKYGCKEYKFelvVQADNEERrsvrlyHYPHWTKNMVPASS-KVVLNLVKKIgkKKSQAPVVV
 ...  . |.|. ..    .  | . . .  | . .   .   . |    | .|.|||      .  ||  ..  .|     |....|.  ..   ||||
keserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl...vGgddeer......flehwqgdvnnssdvysplrvlrkl..rnlskpvvv

QCETGVNQSAELVFVD-AMCTLLtRQVEVNFDVL--FRQMRSQKALAMTQLLHFLHSIATVM
|.  || ..| || .. |...|| |   . . ||     .| .. |..   | .|     |.
qdilGvskaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 161-410 1.6e-25 84.7 In-house 30-272 (288) alignment 
Range on Protein: 161-410
Range on HMM: 30-272/288.0
NIAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADpNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVyPMY
| |.    |.| .|. ... ...|. | ||||| | .  .||.|| .   . |.  | .| || ||.. .| |. .. || || |.       ..    |
neasidiidsfianptrdryenlprcditrvklsd.dpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeks.aey

YPNKPETFNNFGQFfvyCKTVtQPKTKYGCKEYKFELVVQADNEERRS-VRLYHYPHWTKNMVPASSKVVLNLVKKIgkKKSQAPVVVQCETGVNQSAEL
.| |      .|..   |. | . | .   |  |  |.    . | .  |.  |. .| .. || . .  |.|.. .  |. | |.||....|| ... |
fPsklGekarigrl...ctvv.kkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqkPivvhssaGvGrtgtl

VFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIK
...  . . |  .  .    |. ..| ..  |..    .|.    |.. . 
ililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 134-412 1.7e-25 84.1 In-house 15-288 (302) alignment 
Range on Protein: 134-412
Range on HMM: 15-288/302.0
KYIKFMDQvafIENGTTLSTFfsNHLMNI-APTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNiVYYIHANHIMFDHLKKTYITTQHPLPGTL---ND
. .|....   ...... ..|  ... .. ... .  ||  |. ||| .|||..|...|||.  .   |..| ..   .|... | .| |  ..    ..
eakklvks...ldtaevkkef..kkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaep.dsyvnaskvevPeltrsiilaQlpkvdsedsvee

FWAMVADQKVETIVSLTSSSSASNpnVYPMYYPNKPETFNNFGQFFVYCKTVTQPKTKYgcKEYKFELVvQADNEERRSVRLYHYPHWTKNMVPASSKVV
|| ||...|. ..| |  .   ..      ..|.| ......|..||  . | . . .   ..|  |..   .  .   . .|.   | .. || .   .
FWrmvfqekivsvvilvgeeelkk..tlselfpkksgdykeygkmfvNnrkVekaeeek..tryviEvl.PegcsnsvlanvyvltnWkqkkvpvkyael

LNLVKKI--GKKKSQAPVVVQCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIKIR
 . ..|.   | |.....|.  . |.   . .. . .  . |... |.|   . ...|||.. |. .|  .     ... .|| .
iktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 167-388 1.9e-25 84.4 In-house 37-256 (315) alignment 
Range on Protein: 167-388
Range on HMM: 37-256/315.0
RSDAFHGNTFKNQRKDVPCIDDTRVKL----ADPNiVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNvYPMYYP
|.   . |  ||. |..  .| .||||     .|.   || | .|   .  |.||..| ||. ...||| || ..|| ||| .|  .     .    |.|
rvaretinfkknryknilPldsarvkleviddsPd.sdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik.crqywP

NKPETFNNFGQFFVYCKTvTQPKTkyGCKEYKFelvVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIG--KKKSQAPVVVQCETGVNQSAELV
..     .||.. |     ... |  .    |.   |  . || | |  ...  | .. |.  .  .|.|.|..   ..| . ...| | .|| ..  ..
drkadsvefGsikvells.leadt..dgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvi

FVDAMCTLLTRQVEVNFDVLFRQMRSQK
 .| .   . |.  |.   . ...|...
sidevvaqikrtrsvdvfnfvknlrakr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 169-389 1.9e-25 84.6 In-house 43-264 (297) alignment 
Range on Protein: 169-389
Range on HMM: 43-264/297.0
DAFHG---NTFKNQRKDVPCIDDTRVKLADPNIV---YYIHANHIMFdhLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpnVYPMYYP
.       |  |.. |..  .|  |||||  |      |. | ..     |. .|||| | . |..|||||| |..| ||| |.  .   .      |..
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg..nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk..kcaryWs

NKpeTFNNFGQFFVYCKTVTQpktKYGCKEYKFELvVQADNEERRSVRLYHYPHWTKNMVPA--SSKVVLNLVKKIGKK---KSQAPVVVQCETGVNQSA
.|  . ..||.  |  ..|..   . |  . ..|.  . ..  || |. |.. .| .. |.   | . .|.|.. . |.   ....|..| | .|| . .
dk..gvttfGdvsvvllsvse...reGfikrelev.tkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg

ELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKA
 |. .| . .   |. ||.   | ...| .. 
vlltidsvvaeakrekevdifglvkklrqerp
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 174-397 2.9e-25 83.8 In-house 47-266 (287) alignment 
Range on Protein: 174-397
Range on HMM: 47-266/287.0
NTFKNQRKDVPCIDDTRVKLADPNiVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNKPEtfNNFGQ
|  ||. ...   |. || | . .   || | .|   . || .| .. |.  |. .|| .. |..|..|| |.      .   |  |.|..      .|.
nkdknRltqilvpdnyrvllkgeh.pdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcy.qyWpeeks..vvlGe

FFVyckTVTQPKTKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNM-VP--ASSKVVLNLVKKIGKKKSQAPVVVQCETGVNQSAelVFVDAMCTLLT
. .   .... ... |. | |.|.  .  ......|. |..  | ..  |.  ... .|..   |  .|......|| |  .| .||  .|. |  |.  
yni...ellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsa..mfcaaattink

RQVEVNFDVL--FRQMRSQKALAMTQLLH
 . |   ||.  ....| ||  ..    .
ckteGviDvfqvlksqriqkpgsvqtveq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 177-411 3.4e-25 83.8 In-house 21-257 (290) alignment 
Range on Protein: 177-411
Range on HMM: 21-257/290.0
KNQRKDVPCIDDTRVKLADPNIVY---YIHANHIMFDHLKkTYITTQHPLP-------GTLNDFWAMVADQKVETIVSLTSSSSASNP-NV--YPMYYPN
..|| .|| . .||| | .    .   |||||.. . .     | || |.         |...|| |. . ||. .| |   .  |.  .      |.|.
mdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

KPETFNNFGQFFVYCKTVTQPKtkyGCKeyKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGkkKSQAPVVVQCETGVNQSAELVFVD
. ..  .|. . | ||   . .   . .  . ||||. |.||   |  . .  |.|  |. ..|..|.|..|.   .|..||.| |  |. .|| |  ..
svgeelkfkgltvkCkskeked...dve..tRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaaii

AMCTLLT-RQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMkfikI
  . ..   . .|.. ..  ..|.|.|||.|. | . . .| ..    .
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv....l
0041856 (Phosphotyrosine protein) phosphatases II 174-396 4.8e-25 83.6 In-house 1-160 (182) alignment 
Range on Protein: 174-396
Range on HMM: 1-160/182.0
NTFKNQRKDVPCIDDTRvkladpnIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTssssasnpnvYPMYYPnkpetfnnfgq
|  ||  .|....| .|          ||.|| .....  ...| ||.||..|..||. |. .... |||.||           ..|.|           
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..........eelywp...........

ffvycktvtqpktkygckeykfelvvqadNEERRSVRLYHYPHWTKNMVPAsSKVVLNLVKKIGKkkSQAPVVVQCETGVNQSAELVFVDAMCTLltrqv
                             ... | .  |.|  |  . ||     .|...... .  .. ||.| |  ||. .. ||  . |..|     
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.....

EVNFDVLFRQMRSQKA--LAMTQLL
.|...  ....||..     . . .
gvsleeavklvrsrRpgmvitpnqy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 174-409 6e-25 82.6 In-house 48-279 (439) alignment 
Range on Protein: 174-409
Range on HMM: 48-279/439.0
NTFKNQRKDVPCIDDTRVKLAD-PNI--VYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpnvypmYYPNKPETFnn
.  ||. |||   | ||| | . | .   .|| ||.|   . .| ||.|| |   | .||| .| ..|. ||| ||    . .      |.| . |..  
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk......ywpsdaevc..

FGQFFVYCKTVTQpKTKYGCKEYKFELvVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKI---GKKKSQAPVVVQCETGVNQSAELVFVDAMCT
.|.  | .    .   .|  . .|     .  .|  |.|  .||  | .. ||| .  ||.... |     |.   ||||.| .|| ..  .. .|    
ygdiavrvdrnie.lpnyvirgfkvfn.erdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdiale

LLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFI
 |  . .|. . . . .| |.   . .| ...    .|.. |
qlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 159-399 1.1e-24 82.1 In-house 25-267 (307) alignment 
Range on Protein: 159-399
Range on HMM: 25-267/307.0
LMNIAPT-SRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNI-VYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNV
| . .|     .||. || ||. .||.|.| .|. .  . .   |||||..      | .| .| ||  |  .||||. ..|||... |      .. ..
lakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikc

yPMYYPNKPETFNNFGQFFVyCKTVTQPKTKYGCKEYKFELVVQ---ADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIgkKKSQAPVVVQCETGV
   |.| .    . ||.      .|..  .|  . . ..  | .      .. |... . .  |  . ||      .||.. .  .  . |||| | .||
.eqywpleegqklvfgeapn.tisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav..rydtnpvvvhcsaGv

NQSAELVFVDAMC-TLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFL
 .|  .| .  .   ... .   . . | ...|||.  |. . . .|
GrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 174-437 2e-24 81.1 In-house 49-307 (315) alignment 
Range on Protein: 174-437
Range on HMM: 49-307/315.0
NTFKNQRKDVPCIDDTRVKL---ADPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpNVYPMYYPNKpetFNN
|  ||.  ..   | .||.|      .   |. || |     |. ||..| |.. ...||| .| .... .|| ||.  .  . .    |.|.|      
nkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegek.rkaekywpdk...kvi

FGQFFVYCKTvTQPKTKYGCKEYkfeLVVQADNeeRRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGK--KKSQAPVVVQCETGVNQSAELVFVDAMCTL
.|.. |  |   . .|.| .. .    ||  ||   | |  .||  | .  ||...  ..||.... .  ..| ...|| |. || ..  .. .||.   
yGkitvtrks.eevnteytvrtl...svvfgdn..irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldq

LTrqVEVNFDV--LFRQMRSQ--KALAMTQLLHFLHSIaTVMKFIKIRFSAMPSHYAAQMDSILpAISKDFGY
.   .|   ||  . ...|..  |.... .  .|....  .  |.    |     |  . ||.| | | | | 
ae..aenaidvynfitgvrqnrikmvqvaeqyqfiyda.lletfvcgdtsiaqdlylqrydsll.apspdtgs
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 174-406 2.3e-24 80.6 In-house 55-286 (305) alignment 
Range on Protein: 174-406
Range on HMM: 55-286/305.0
NTFKNQRKDVPCIDDTRVKLADPNIVYYIHANHIMFDHL-KKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPN-KPETFNNF
.  ||. .|||| | . |||..|. . |||||..    . .| .| .| ||  |...|| || ..||| || |  .    . ..   |.|  . |  .  
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca.qywpaaqgeklelk

GQFFVYCKTVTQPKTKYgcKEYKF-ELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIgkKKSQAPVVVQCETGVNQSAELVFVDAMCTLLT
.   |   . ..|  .    | .   | .    ... |||  .. .|    ||      |.|.  |  . |. |.||.| .|. ..  .| .. .   ..
sgivvenvsgskpmerd..aeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai..rgskvpivvhcsagigrtgtivaieyilekia

RQVEV-NFDVLFRQMRSQKALAMTQLLHFLHSIATVM
 . ..  .  | . .| |.| .. . ...|.    ..
enkpcppmpelvkalrdqrafsiqndvqylfihrvml
subfamily_PTPN14_pd Subfamily PTPN14 170-410 3.3e-24 80.4 In-house 45-297 (300) alignment 
Range on Protein: 170-410
Range on HMM: 45-297/300.0
AFHGNTFKNQRKDVPCIDDTRVKLAD--PNIVYYIHANHIMF--DHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNKP
.   |. ||. |||   .|.||.|.    |   || | .|       ...||..| ||. |..||| || .|.|. || ||..    .   .  |.|.. 
klpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf.kyfPkle

E--TFNNFGQFFVYCKTVTQPKtKYGCKEYKFELVVqadNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIG---K--------KKSQAPVVVQCETG
.     .||.| |. | ... . ..  . .|.. .     .|.|.|    |  |... ||   |  |. ....    .        |.|. ||.| |  |
skkktvefgkfkvttkfsedsd.svittglklkhlp...skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaG

VNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIK
| ..  |. .| . . |  . |.. .  ....| |. | . .|  .     ...|..|
vGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPRA_pd Subfamily PTPRA 169-395 3.5e-24 80.3 In-house 53-280 (330) alignment 
Range on Protein: 169-395
Range on HMM: 53-280/330.0
DAFHGNTFKNQRKDVPCIDDTRVKLADP---NIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNkp
 .   |  ||.  ..   | .|| |.     .   || | .|   . |...|..| |.  |..||| |. .||  ||| ||      .   .  |.|.  
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekca.qywPd..

ETFNNFGQFFVYCKTVTQpKTKYGCKEYKFELVVQAD-NEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQ--APVVVQCETGVNQSAELVFV
|    .|.  |  . .|    .|  ...  . . .|  ... | || .|.  | .  ||. .. .|.|.||. |.. |   |.|| | .|| ..  .. .
eGlvtyGnirvevedetv.lvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivl

DAMCTLLTRQVEVNFDVLFRQMRSQKAlAMTQL
||.   .  .  |.     ...| |..  | | 
davlervkaerkvdvfefvkrlrlqrp.qmvqt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 173-386 1.3e-23 77.8 In-house 42-256 (515) alignment 
Range on Protein: 173-386
Range on HMM: 42-256/515.0
GNTFKNQRKDVPCIDDTRVKL---ADPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpNVYPMYYPNKPETFN
 |  ||. |..  .| .||||    |     |. | .|   .  |.||..| |.. ...||| .| ...| ||. .|  .          |.|.||    
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdk.ikcgkyWPdkpgdsv

NFGQFFVycKTVTQPKTKYGCKeYKFELVvQADNeeRRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKK--SQAPVVVQCETGVNQSAELVFVDAMCT
.||.. |  ..|.      | |  |.... . |.   | |  .|.  | .. ||  .. .| |.|..  ..   . |... | .|| .   .. .| . .
kfGsikv..elvsleactggik.rkltvl.kgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvva

LL--TRQVEV-NFDVLFRQMRS
    || |.| ||    || | 
hakttrmvdvfnfvtnirqkrp
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 170-392 3.9e-23 76.7 In-house 42-266 (290) alignment 
Range on Protein: 170-392
Range on HMM: 42-266/290.0
AFHGNTFKNQRKDVPCIDDTRVKLADP----N-IVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpNVYPMYYPNK
    |  .|  ...   || |. | .     .    ||.| .|   . || || || |.. || ||| .. ..||  || ||.  .  . ..   |.|..
ltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegk.vkCqqYWpds

pETFNnFGQFFVyckTVTQPKTKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNM---VPASSKVVLNLVKKIGKKKSQAPVVVQCETGVNQSAelVF
 .| . .|.| .   .... .|  .  | |.|.  .  .....||  |.   | ..     |... .|.. . |. .|. . ..|| |  .| .||  ||
.dtka.ygefsi...kllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsa..vf

VDAMCTLLTRQVEVNFDVL--FRQMRSQKALAM
. |. |.   . |   ||.   ...|.||   .
caaattinkcktegvidvfqvlksqRiqkpgsv
subfamily_PTPRN_pd Subfamily PTPRN 172-390 6.7e-23 75.8 In-house 54-273 (297) alignment 
Range on Protein: 172-390
Range on HMM: 54-273/297.0
HGNTFKNQRKDVPCIDDTRVKLA---DPNIVYYIHANHIMF-DHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVyPMYYPNKPET
. |  ||. |.|   |..||||    . .   || |  |.  |  . .||.|| ||. |. ||| || .| |  ||.||. .  .  ..   |.|.. . 
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc.krywpdeGse

FnnFGQFFVYCKTVTQPKTKYGCKEYKFElvvQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKK--KSQAPVVVQCETGVNQSAELVFVDAM
   .. . |   .       |  . . .    . ...| |.|  .|.  |... ||||.| .|.. .|. |      .|.|| |  |. ..   . .| .
v..yhiyevhlvsehiwcddylvrsfylk...nlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlv

CTLLTRQV-EVNFDVLFRQMRSQKAL
.. |.. | |..       .| |.. 
lnrllkGvkeidiaatlehlrdqrpg
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 174-364 1e-22 75.1 In-house 37-222 (281) alignment 
Range on Protein: 174-364
Range on HMM: 37-222/281.0
NTFKNQRKDVPCIDDTRVKLAD----PNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSsASNPNVYPMYYPNKPETFN
|  ||.  ..||.| .||.|       |   |||||.|    ||. || || |   |  ||| |. ...  .|| |      .| .    |.| .     
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfl.etnrekcaeyfprnahccl

NFGQFFVYCKTVTQPKTKYGCKeykFELVVqadNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKkSqAPVVVQCETGVNQSAELVFVDA
.| .. |  .  |  |.    .   ..|     . | | .  . .  |    || ||.|.|....||  . | .| |..| .|| .|  |. |. 
qfdklsvsyedstvnkslvttr...lnlsy...egetrlithwlwkewpdwqvpessevmlkilrkirar.s.tppvihcsagvgrsgtlmavei
subfamily_CG7180_pd Subfamily CG7180 173-388 2.7e-22 73.8 In-house 41-269 (296) alignment 
Range on Protein: 173-388
Range on HMM: 41-269/296.0
GNTFKNQRKDVPCIDDTRVKLAD---PNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpnVYPMYYPNKPetFN
 |  ||.  .|   | .|| |      .  .|| | ..     || || |. |   |...|| .| |......| ||   . ..   || |.|||    .
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak..mypsywpnks..ke

NFGQFFVYCKTVTQpKTKYGCKEYKFELV-------VQADNEERRSVRLYHYPHWTK-NMVPASSKVVLNLVK-------KIGKKKSQAPVVVQCETGVN
..|..||   .. |  ..   ...|            .  . | | |.|...  |   . || |.. ...|..       |. ... ..|||| .. |. 
qygeifveiveekq.yanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

QSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQK
 |   . .||   |. .. ||..    ...| ..
RsGvylaidanlelvekeeevdvFeavktlrrsR
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 170-394 2.8e-22 74.0 In-house 29-251 (283) alignment 
Range on Protein: 170-394
Range on HMM: 29-251/283.0
AFHGNTFKNQRKDVPCIDDTRVKLAdPNIVYYIHANHIM---FDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNpNVYPMYYPNKpe
. . |  ||. ...   |  ||.|  ..   || | .|.    .. .| || .| ||  |  ||| || |.|. .|| ||      .      |.|..  
sadenkrknrnqeivpadqwrvelk.sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlr.ikCsqyWPkr..

TFNNFGQFFVYCKTVTQPKtKYGCKeykfELVVQADNEERRSVRLYHY--PHWTKN--MVPASSKVVLNLVKKIGKKKSQAPVVVQCETGVNQSAelVFV
   ..|.| |  .  |  .  .  |    ||... ..  . .. | ||    |..     .  | | .|.|.   ... ..|.|| | ||. ..|  ||.
GsedyGeftvtlrkettsn.sfiik....elllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrta..vfi

DAMCTLLTRQVEVNFDVL--FRQMRSQKALAMTQ
 |....   . |   ||    . || |.  |. .
aasasvkdaltesvvdvfavvkimreqrmmavqt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 173-389 5.7e-21 70.0 In-house 47-268 (325) alignment 
Range on Protein: 173-389
Range on HMM: 47-268/325.0
GNTFKNQRKDVPCIDDTRVKL---ADPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASnpNVYPMYYPNKPETFN
 |  ||. |.|  .| .|| |    |     || |...  |  |......| ||. |.||.| .| | .   .| |         .   .|.|..     
enkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgk..drcavywpkemgksk

NFGQFFVYCKTVTQPkTKYGCKeyKFElVVQADNEERRSVRLYHYPHWT---KNMVPASSKVVLNLVKKIGK-----KKSQAPVVVQCETGVNQSAELVF
.|| . |  .|. .  . |  .  ... | |... | |||. ...  |     .  ||.   .|.|||.. .      |. .|..| | .|| ..  .. 
tfGglevklrtieei.sdyvhr..vld.vkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

VDAMCTLLTRQVEVNFDVLFRQMRSQKA
. ..   .  . .|.     ...| .. 
lysalakvieesrvdifgfvkklrkdrp
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 168-408 6.4e-21 69.2 In-house 46-289 (310) alignment 
Range on Protein: 168-408
Range on HMM: 46-289/310.0
SDAFHGNTFKNQRKDVPCIDDTRVKLADPNI--VYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNKP
 .|.. .  ||.  || | |..||||   .     |||||..  ..|..|.| .| ||  |. ||| |. ... |.|. |   .    |..   |.|   
yeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcv.gywpslg

ETfNNFGQFFVYCKTVTQpkTKYGCKEYKF-------ELVVQADNEERRSVRLYHYPHWTKNMVPASSkvVLNLVKKIGKKKSQAPVVVQCETGVNQSAE
 | . .|   |   . .    ..   .           .  |  | .   | | ..| |    ||     .  . ...  .  . |.||.| .|...   
vt.etygcirvtnlsess..eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek..chtvpqrllaqvrhgpcvvhcsagkdrlyv

LVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKF
.| ..     | |  .|... .  ... ..|  .   | .|      . |
vvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 143-387 8e-21 68.9 In-house 11-217 (392) alignment 
Range on Protein: 143-387
Range on HMM: 11-217/392.0
AFIENGTTLSTFFSNHLM----NIAPtSRSDAFHGNTFKNQRKDVPCIDDTRVKL---ADPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVA
||.|.    . ||..       .| |  ..   . |  ||. |..  .| .||||    | .   |. | .|   . .|.||..| | . .|.||| || 
afveknrhsalffeefhdlpgpdiyp.qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvf

DQKVETIVSLTSSSSASnpnvypmyypnkpetfnnfgqffvycktvtqpktkygckeykfelvvqaDNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKK
...| ||. .|    .                                                    .. |.|  .|.  |  . ||  .  .|...|.
qenvttiamvtklkegd.................................................kgddartvaqfhftewPdkdvpkhtssllkfike

IGKKKSQ--APVVVQCETGVNQSAELVFVDAMCTL--LTRQVEV-NFDVLFRQMRSQ
.  .  |   |....| .|| ... .. .|.. .    || |.| || .  |. |  
vkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpy
0043147 (Phosphotyrosine protein) phosphatases II 200-392 1.1e-20 69.4 In-house 6-144 (172) alignment 
Range on Protein: 200-392
Range on HMM: 6-144/172.0
YYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSssasnpnvypmyypnkpetfnnfgqffvycktvtqpktkygckeykfelvV
.||.|... . .  . .| || ||. ||.|||.|. .... .||.||.                                                   .
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................l

QADNEERRSVRLYHYPHWTKNMVPaSSKVVLNLVKKIGK---KKSQAPVVVQCETGVNQSAELVFVDAMCtlltrqVEVNFDVLFRQMRSQKALAM
     . |..  |.|  |  . || .....|.... | .   .... ||.| |  ||. .. ||  . |.        ....  ....|...  | 
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 174-368 4.4e-20 66.9 In-house 3-198 (237) alignment 
Range on Protein: 174-368
Range on HMM: 3-198/237.0
NTFKNQRKDVPCIDDTRVKLADPN-IVYYIHANHIM-FDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSAsNPNVYPMYYPNKpETFNNF
|  ||.  .. . | .|| |  .   . || |...  ||   |.||..| ||  . .||| || ..|   || ||      |      |.|.  .  . .
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltglieg.nelkchkywpst.dqpaay

GQFFVYCKTVtQPKTKYGCKEykFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQ----APVVVQCETGVNQSAELVFVDAMCT
|.. |  |   .  . |  .   . |...   .| | .  |..  | .. ||  .  .| . |.| ..       .| .. | .|| ... .. .|||  
gvltvslkkk.eefsdytvrs..lllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

L
 
q
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 156-392 4.7e-20 66.4 In-house 29-262 (303) alignment 
Range on Protein: 156-392
Range on HMM: 29-262/303.0
SNHLMNIAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNivyYIHANHIMFDHLKKTyITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSAsNPN
 .    . |.   . |  |  ||.  || |.| ..|||.|     ||||... .|  ||. | || ||. |  ||| |. .|||  .. | . |   .  
ekvvsylppsvsknqfvknmdknrfvdvicldhskvklsdss...yihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdsey.dkl

VYPMYYPNKpETFNNFGQFFVYCKTVTQPKTkygCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPAS-----SKVVLNLVKKIGKKKSQAPVVVQCE
   . .|.. . | .| . ..      . .     . ... ..  .. . .  . ..||  | .| .|.       | . .|   . |     | |    
ggdsvfprn.qdflkfeersirvgefkrvel...gdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsl

TGVNQSAEL-VFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAM
.|. ..  . .|  |  .| . |  ...   . ..|  .  |.
sgcgragtfalfetahlslhseqasldlvkclenvrngrlhav
0049772 (Phosphotyrosine protein) phosphatases II 171-410 7.2e-20 67.4 In-house 43-281 (314) alignment 
Range on Protein: 171-410
Range on HMM: 43-281/314.0
FHGNTFKNQRKDVPCIDdTRVKLADPNI--VYYIHANHIMFDhlkKTYITTQHPLPGTLNDF----------WAMV--ADQKVETIVS------------
.  |  ||  .|... | .||.|   ..  . ||.|...      ...| ||.||. |..||          | ||   |..| .||             
lflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------LTSSSSASnpnvyPMYYPNKPETFNnfgqffvycktvtqpktK-------YgckeykfelvvqadneeRRSVRLYHYPHWTKNMVPaSSKV
         |.. .        ... .  .|...                 .       .                  | .  |.. ... . .| ... 
LdaAlgKtpllildgng.....neptaadlellk.................eelydpelf.................erlgikylripvpDgsap.lled

VLNLVKKIGKKKSQAPVVVQCETGVNQSAELVFVDAMCTLLtrqvEVNFDVLFRQMRSQKA-----LAMTQLLHFLHSIATVMKFIK
.. ... | . . . ||.| |  |.. .. .|... .. ||     |...  ....|..        .. ||....     .....|
fdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
0051429 (Phosphotyrosine protein) phosphatases II 201-426 8.6e-20 67.0 In-house 6-242 (272) alignment 
Range on Protein: 201-426
Range on HMM: 6-242/272.0
YIHANHIMFDHL---KKTYITTQHPLPGTLNDFWAMvADQKVETIVSLTSSSSASNPN---------VYPMYYPNKPETFNNFGQFFVYCKTVTqpkTKY
||.|...   .    ..... ...||| | .|||.. ..... |||.|.| .     .         .. . ...  ... ..|...|..  ..   ...
yiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee...lll

GCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSkvVLNLVKKIGKkksQAPVVVQCETGVNQSAELVFVDAMCTLLTRQVEVN--------FDVL
 .  ....|. . ...| | |...||  |    || ..  .|.|.. . .   . ||.| |  |.. .. .| .. .   ..... |.         .  
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

FRQMRSQKALAMTQLLHFLHSIATVMKFIKIRFSAMPSHYAAQMDS
 ...|.| . |     ..|     ......  .|. .....| .| 
veelraqrpgavqteeqylflyeallellrsllsvraeyllaalda
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 174-390 8.1e-19 62.5 In-house 38-258 (287) alignment 
Range on Protein: 174-390
Range on HMM: 38-258/287.0
NTFKNQRKDVPCIDDTRVKLAD-PN-IVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNKpETFNNF
.. ||.  ||  |||||| |.  ..  . || ||..   . ....|..| |.. |..||| .| .... ... .|     .  ..|  |.|.. |     
avkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy.kywPer.evPmrv

GQFFVYCKTVTQPKTKYGCKEYKfelVVQADNEERRSVRLYHYPHWTKNMVPAS----SKVVLNLVKKIGKKKS---QAPVVVQCETGVNQSAELVFVDA
| . |     .. . .|| . ..   ..... .| | |. ...  | .. .. .     . ||.  ..|  ...     |.|| ...|. .|  |. . .
GGysvvlldydikePeygvralr...lidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlv

MCTLLTRQVEVNFDVLFRQMRSQKAL
.   |    .|.      ..| ..| 
lvsrledlGrvdvaavvirlreyraa
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 177-389 1.6e-18 61.7 In-house 36-239 (267) alignment 
Range on Protein: 177-389
Range on HMM: 36-239/267.0
KNQRKDVPCIDDTRVKLADPNIVyYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYPmyypNKPETFNNFGQFFV
.|.  |.   ||||| | . .   || | ..   . |...| || ||  |  ||. .. |||| .|| || .     . ..|     |    ... .. |
rnrlddnlpyddtrvilrtkeee.yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwP....Pkmgqakkyqdltv

yCKTVTQPKTKYGCkeykFELVVQADNEERRSVRLYHYPHWTKNMVPA-SSKVVLNLVKKIGKKKSQAPVVVQCETGVNQSAELVFVDAMCTLLTRQVEV
  ... . .  |        | ..  ||  . | ||.| .|  |       | .. .. |   .. . |.||.|. || .|  .. .|..   . ..  .
.ehslekeendyqi....itlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvs

NFDVLFRQMRSQKA
.   ..|..|||. 
difdflrkirsqri
0046846 (Phosphotyrosine protein) phosphatases II 194-403 2e-18 62.2 In-house 7-166 (176) alignment 
Range on Protein: 194-403
Range on HMM: 7-166/176.0
ADPNIVYYIHANHIMFDHlkktYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVY---PMYYPNKPetfnnfgqffvycktvtqpktkygc
 ... ..||.|| |. ..    .|.||.|||.|| ||..|. .......|.||.    .  ...   | .. ..                          
gldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

keykfelvvqadneerrsvrLYHYPHWTKNMVPASsKVVLNLVKKIGKKKSQA-PVVVQCETGVNQSAELVFVDamctLLTRQVEVNFDVLFRQMRSQKA
                     |.. .|  . || . . .|.|.. | .  ..  ||.| |  |.. .. ||  .    || ..  .. .  ....|.|. 
....................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp

LAMTQLLHFLHSIA
| . |  .... . 
lgavqtpeQyrfly
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 160-410 2.1e-18 61.1 In-house 29-277 (312) alignment 
Range on Protein: 160-410
Range on HMM: 29-277/312.0
MNIAPTSRSDAFHGNTFKNQRKDVPCIDDTRVKLADPNiVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVypM
 || . |   ||      |.  .. | |  |  ||  .  .||||| .      . ...|| ||  |   || ..      .|. |..    .. ..   
gnivsdsectaflkfkdlnrypniqcwdrgrftlagde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekc..a

YYPNKPETFNNFGQFFVYCKTVTQ----PKTKYGCKEYKFELVVQADNEERRsVRLYHYPHWTKNMVPASSKVVLNLVKKIgkKKSQAPVVVQCETGVNQ
 | .   .| .. .  || . .|.     |.|       . .||.|  .| . .  | .  |    .| |    | |.  .  || . ||. .| .|| .
kyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsav..kkdkkpviahcsagvgr

SAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIK
.  |.....| . |      |    |  .| ..| ..  . ...... .|..|. 
tgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
0036282 (Phosphotyrosine protein) phosphatases II 201-388 2.7e-18 61.7 In-house 4-149 (174) alignment 
Range on Protein: 201-388
Range on HMM: 4-149/174.0
YIHANHIMFDHLKKTYITTQHPLPgtlndFWAMVADQKVETIVSLTSSSSASNPNVYPMYYPnkpetfnnfgqffvycktvtqpktkygckeykfelvvq
||.|... . .  . .| .|.||.     ||.|. .....|.|.|...    .  ..  ..                                       
yinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe......................................

ADNEERRSVRLYHYPHWTKNMVPASSKvVLNLVKKIGKKKSQ---APVVVQCETGVNQSAELVFVDAMCTLLTrQVEVNFDVLFRQMRSQK
  . ..|..  |.| .|  . || .|. .|..|| . .  |.    ||.| |  ||. .. ||  . |...|  .  |.   |.|..|.|.
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqr
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 216-423 1e-17 59.1 In-house 37-234 (255) alignment 
Range on Protein: 216-423
Range on HMM: 37-234/255.0
YITtqhplpgTLNDFWAMVADQKVETIVSLTSSSSASNPNVyPMYYPNKPETFNNFGQFFVYCktvTQPKTKYGCKEYKFELVVQAdNEERRSVRLYHYP
|.        |.. |. ..  .| |..| |.    ..  .    |.| . .    . .  | .   |.. ..   .  .  . .     . . |. |.| 
ysl.......tvdkfyqtivqtktevvvmlcdfaeegvekc.ssyfplekdeklkladvnvtt...tkssadvvlrtleitstlge.kkkthtvkhysyk

HWTKNMVPASSKVVLNLVKKIGKKksqAPVVVQCETGVNQSAELVFVDAMCT-----L-LTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFI
 | ... |  .. .||..| . .     .|||.|.||. .|| .|... .       |  |  ||...  | ...||... |. . |..  || .|....
GWieknaPelareilnilkvvrds...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

kIRFSAMPSHYAAQ
    ...  .|   
.fpkgeleakyqei
PTPc_DSPc_SM00012 309-406 2.4e-17 58.4 In-house 2-104 (105) alignment 
Range on Protein: 309-406
Range on HMM: 2-104/105.0
VRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQ----APVVVQCETGVNQSAELVFVDAMCTLLTRQ-VEVNFDVLFRQMRSQKALAMTQLLHFLHSIA
|. |||. |..  || .|. .|.|.... |.|..    .||||.| .||.... .| .| ..  |...  ||..  .....|.|.. .....  .|  ..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TVM
 ..
all
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 149-245 4.4e-17 56.6 In-house 11-116 (347) alignment 
Range on Protein: 149-245
Range on HMM: 11-116/347.0
TTLSTFFSNHLMNIAPTS-RSDAFHGNTFKNQRKDVPCIDDTRVKLADPN--------IVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKV
..|||.| ..| | .|.   |  .  .  ||. |||  ||.||| |.  .        .  || | || ||  .| || ||.||| |. ||| ||   ||
aslstyfdenlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkv

ETIVSL
  .|..
tqvvti
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 172-325 3.7e-16 53.8 In-house 30-182 (297) alignment 
Range on Protein: 172-325
Range on HMM: 30-182/297.0
HGNT-FKNQRKDVPCIDDTRVKLAD-PNIVYYIHANHIMFDHLK--KTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYPmYYPNKPET
  ..  ||. .|.   |||||||   .    || |....| . .    || .| ||  |..||| .||.| | .|| ..          .| |.|.  . 
rnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap.ywpsvvqe

FNNFGQFFVycKTVTQPKTKYGCKEYkFELVVQADnEERRSVRLYHYPHWTKNMVPAS
  . |.. |  . ...   ..       || .    .|.| ||   .  |    ||. 
rlkagdvvv..eflsstsdefdrvil.telqliyr.sesrvvrhvqflswpdhGvpsd
0049260 (Phosphotyrosine protein) phosphatases II 211-391 9.6e-16 53.3 In-house 6-132 (152) alignment 
Range on Protein: 211-391
Range on HMM: 6-132/152.0
HLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYPMYypnkpetfnnfgqffvycktvtqpktkygckeykfelvvqadneerrsvr
. .. .| ||.|.| ||.||| |. .... |||.||. .    . ..  .                                                  
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................

LYHYPHWTKNMVPASSKVVLNLVKKIGK--KKSQAPVVVQCETGVNQSAELVFVDAMCtlltrqVEVNFDVLFRQMRSQKALA
 |..  |  . || .| ..| |.. | |  .... ||.| |  ||. .. ||  . |.        |...  ....|...  |
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpga
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 175-387 1.8e-15 51.7 In-house 9-219 (239) alignment 
Range on Protein: 175-387
Range on HMM: 9-219/239.0
TFKNQRKDVPCIDDTRV---KLADPNIVYYIHANHI-MFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNKPETFNN
  ||.  ..   | .||   ||..     || |...  .|   |.||.||  .  .  ||| |. ...   || ||      . ...  |.|.    . |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkch.qywpdstskycn

FGqffVYCKtVTQPKTKYGCKEYKFElvvQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKK--SQAPVVVQCETGVNQSAELVFVDAMCTL
.    |  .  |.  . |  . . .    |  . | | |  ||.  |  . ||  .  || | .|| |       | |..| .|| ..  .. .|||   
lr...vtlr.ktevfadyiirtfvms...qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

LTRQVEVNFDVLFRQMRSQ
  .|  |.     . .| .
akkqktvdifnyvkaired
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 175-387 1.9e-15 51.7 In-house 8-218 (239) alignment 
Range on Protein: 175-387
Range on HMM: 8-218/239.0
TFKNQRKDVPCIDDTRV---KLADPNIVYYIHANHI-MFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNVYpMYYPNKPETFNN
  ||.  ..   | .||   ||..     || |...  .|   |.||.||  .  .  ||| |. ...   || ||      . ...  |.|.    . |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkch.qywpdstskycn

FGqffVYCKtVTQPKTKYGCKEYKFElvvQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKK--SQAPVVVQCETGVNQSAELVFVDAMCTL
.    |  .  |.  . |  . . .    |  . | | |  ||.  |  . ||  .  || | .|| |       | |..| .|| ..  .. .|||   
lr...vtlr.ktevfadyiirtfvms...qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

LTRQVEVNFDVLFRQMRSQ
  .|  |.     . .| .
akkqktvdifnyvkaired
0044763 (Phosphotyrosine protein) phosphatases II 190-402 1.2e-14 49.8 In-house 6-163 (178) alignment 
Range on Protein: 190-402
Range on HMM: 6-163/178.0
RVKLA---DPNIVYYIHANHIMfDHlkkTYITTQHPlpgtlNDFWAMVADQKVETIVSLTSSSSASNPNVYPMYYPNKPetfnnfgqffvycktvtqpkt
||.|    ... ..||.|..|. ..    |.... |      |..... .... .||.||.      .. .| .. .                       
rvllsnleglersdyinaseil.pg...lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.....................

kygckeykfelvvqadneerrsvRLYHYPHWTKNMVPASSKVVLNLVKKIGKK--KSQAPVVVQCETGVNQSAELVFVDAMCTLltrqvEVNFDVLFRQM
                         |.. ..  . || ... .|..|. | .   ... ||.| |  ||. |. ||  . |..|      ....  ....
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielv

RSQKAlaMTQLLHFLHSI
|...   . .  ..|. .
rerRp..ivpnpgqlrqL
subfamily_hpo-7_pd Subfamily hpo-7 218-413 5.6e-14 46.7 In-house 42-231 (263) alignment 
Range on Protein: 218-413
Range on HMM: 42-231/263.0
TtqhpLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNvYPMYYPNKPETFNNFGQFFVYCKTVTQpktKYGCKEYKFELVVQAdNEERRSVRLYHYPHW
     |  |.. |. ..  .| |..| |.    ..  .    |.| . .    . .  | .  | .   .   |  ..  ...    . . |. | |  |
l....lvqtidkfyqtivqtktevvvmLcDfneegvek.cssyfPlekdekqklanvnvcttkvqs...dvllktlellstlge.KkkthtvkhysykgW

TKNMVPASSKVVLNLVKKIGKKksqAPVVVQCETGVNQSA-----ELVFVDAMCTLL-TRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIKI
 ... |  .. .||..|   .     ..|| | ||. .||     |||.   . .|  |  ||...  | ...||... |. . ...  || .|..|.  
iekndpelareilnilkvarns...kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvln

RF
 |
nf
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 174-395 8.9e-14 45.9 In-house 40-279 (301) alignment 
Range on Protein: 174-395
Range on HMM: 40-279/301.0
NTFKNQRKDVPCIDDTRVKLADPNI-----VYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNvYPMYYPNKPETF
|.  |. |..  .|| |. |.  .        || |..|     || .| .| |.  || ||| .. ..|. .|| .|     .. .    |.||  .. 
nkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtksk.ceqywpnseaes

NNFGQFFVYCKTVT-QP---------KTKYGCKEYKFEL--VVQADNeERRSVRLYHYPHWTKNMVPASSKVVLNLVKKI---GKKKSQAPVVVQCETGV
..||.| |  .  .  |         | . | .. ..|    |..|. . ..|  ..   | .. |    . ||. . ..    .| . .|||| |  .|
eefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtV

NQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQL
 .|   . |.       ..  |.   . . .| .|  | | |
srsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTL
subfamily_CG42327_pd Subfamily CG42327 189-332 2.2e-13 44.6 In-house 46-186 (319) alignment 
Range on Protein: 189-332
Range on HMM: 46-186/319.0
TRVKLADPNIVYYIHANHIM-FDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASnPNVYPMYYPNKPET--FNNFGQFFVYCKTvTQPK
.  . .| .  .|..|...  .|  .  ||..| .|  .  ||| .| .|.  .|| ||. |     .| . |.| |      . .|.. |  |   . |
vlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselG.ikvcaeylPtketldntslyGdilvtlkg.revk

TKYGCKEYkfeLVVQADNEERRSVRLYHYpHWTKNMVPASSKVVLNL
 .|        |. . |.|| | .  | | .| .  |||. . .. .
dryaistl...llkrvdkeesrelthywy.kwleaevPaeeaaliam
subfamily_ptpA1_pd Subfamily ptpA1 164-359 2.8e-13 44.4 In-house 38-246 (418) alignment 
Range on Protein: 164-359
Range on HMM: 38-246/418.0
PTSRSDAFHgNTFKNQRKDVPCIDDTRVKL---ADPNIVYYIHANHIMFDhLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPNvYPMY
 ||  |  | || ||.  ..  .. |||.|    | .   || ||.|      | .| || ||| |. ||| || ....  || |.  |     .    |
etsegdkkh.ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrik.cdry

YPNK--PETFNNFGQ----FFVYCKTVTQpKTKYGCKEYKFELVVQADNEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQ--------APVV
.|..   | |. .|.    |  |   . .   .   .|     .  . . | | .  |.|  |    .|  .. . .|.. | ... |         |..
wpeqiggeqfsiygngnevfgtysvelve.viqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VQCETGVNQSAEL
|.| .|| ..  .
vhcsagvgrtgtf
0051082 (Phosphotyrosine protein) phosphatases II 201-389 1.2e-12 43.2 In-house 5-133 (151) alignment 
Range on Protein: 201-389
Range on HMM: 5-133/151.0
YIHANHIMFDhlkktYITTQHPLPgtlnDFWAMVADQKVETIVSLTSSSSASnpnVYPMYYPNKPetfnnfgqffvycktvtqpktkygckeykfelvvq
||... .        .. ...||.    ||......... |||.|.|         .| |.|.                                     
yinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg...ycpeylpelg...................................

adneerRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKkKSQAPVVVQCETGVNQSAELVFVDAMCtlLTrqveVNFDVLFRQMRSQKA
      . |. .... |.   .| | . ||...... . |.. ||.| |  |.. .. || .. |.  |     |...  ....|..  
......ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrp
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 213-361 1.5e-12 42.1 In-house 4-154 (199) alignment 
Range on Protein: 213-361
Range on HMM: 4-154/199.0
KKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSAsNPNVYPMYYPNKPETFNNFGQFFVYCKTVTQpKTKYGCKEYKFELVVQADNeERRSVRLY
.. ||.|||||  |. ||| || .     || .       .   ||.|.|    .  ..| . | .||.|  |  |      .   . |     | .  |
qrryiatqhplretmadfwqmvwetgsghivmvnddqkn.keadypfywpttesgtgkygslsvttktitt.kpdytitaliltnnttapp.streishy

HYPHWTKNMVPASSKVVLNLV--KKIGKKK---SQAPVVVQCETGVNQSAELVF
 .  | ..  |  .  |  .|  ... ||     .|||.|.|  |   .  .| 
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfva
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 213-361 1.7e-12 41.9 In-house 3-153 (198) alignment 
Range on Protein: 213-361
Range on HMM: 3-153/198.0
KKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSAsNPNVYPMYYPNKPETFNNFGQFFVYCKTVTQpKTKYGCKEYKFELVVQADNeERRSVRLY
.. ||.|||||  || ||| || .     || .       .   ||.|.|    .  ..| . | .||.|  |  |      .   . |     | .  |
qrryiatqhplretladfwqmvwetgsghivmvnddqkn.keadypfywpttesgtgkygslsvttktitt.kpdytitaliltnnttapp.streishy

HYPHWTKNMVPASSKVVLNLV--KKIGKKK---SQAPVVVQCETGVNQSAELVF
 .  | ..  |  .  |  .|  ... ||     .|||.|.|  |   .  .| 
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfva
subfamily_eak_pd Subfamily eak 160-327 5.1e-12 39.8 In-house 42-199 (332) alignment 
Range on Protein: 160-327
Range on HMM: 42-199/332.0
MNIAPTSRSDAFHGNTFKNQRKDVPCIDDTRvklADPNIVYYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSaSNPNVYPM
. |  |.| .| . | .|   .|   .  |    .  |   || |  . | .. . || |  .    .  || || .||  .|| |       . . .  
lsisetarleavnrnvvkivpydrylvrlts...sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledve.lkleksdk

YYPNKPETFNNFGQFFVYCKTVtqpkTKYGCKEYKfELVVQADNEERRsVRLYHYPHWTKNMVPASSK
|.|.|     .||.. | .|       | .  |..  |...  ||  | |  |..  ||.  .|    
yfpdktreelkfGildverkef....vkrniletr.llelskGnethr.vlhykvfGwtettlpkyed
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 257-416 5.8e-12 39.8 In-house 176-345 (347) alignment 
Range on Protein: 257-416
Range on HMM: 176-345/347.0
YP-MYYPNKPETFNNFGQFFVYCKTVTQP-KTKYGCKEYKFELVVQADnEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKS---------QAPV
.   ..| . . . |.  ...  ..|.   ..|   . |  |.| .    |    ..|    |  .  |   | || ||.   |. |         .|||
hrssffpletdhylnlkgwlintravevdqrnknwmnkytvevvaegc.seatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapv

VVQCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKALAMTQLLHFLHSIATVMKFIKIRFSAM
|| |. |...|| .|.   .   .      . | ||..|| |.|  .|  . . ..| . . ..|... ..
vvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyairaalfylklklqtl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 211-399 2.7e-10 34.2 In-house 88-281 (302) alignment 
Range on Protein: 211-399
Range on HMM: 88-281/302.0
HLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSaSNPNVYPMYYPNKPETFNNFGQFFVYCKTVTQPKTKY----GCKEYKFELVVQ-ADNEE
...|.      |   ||. .||.. . .|  .| |.|    .. . .  || .| .   .||.. |  . | .   ..    . | |. |.  .   .. 
kkekvskkpivpkkstlekhwalieqynvaivvqlcsfve.deekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkv

RRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKSQapVVVQCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLF---RQMRSQKALAMTQLLHFL
...| . ..  | .   |. ..  |...|     | .  |.| | .|| ..  || .     | ...   ..  .    || |       .||...|
kktvdilafsawpdhGapkeaytaldilkfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 199-252 3.4e-10 33.8 In-house 90-145 (349) alignment 
Range on Protein: 199-252
Range on HMM: 90-145/349.0
VYYIHANHIMFDHL--KKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSAS
  || ||.. . ..  .| ||.|| ||| |..||. ..  ..|. ..||...   |
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 157-248 4.7e-09 30.2 In-house 78-171 (244) alignment 
Range on Protein: 157-248
Range on HMM: 78-171/244.0
NHLMNIAPTSRSDAFHG-NTFKNQRKDVPCIDDTRVKLADPNIV-YYIHANHIMFDHLKKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSS
. ..   |.   |||   |..||.      .|  || |.  ..   || |  .        || |||||  |  ||| |. ...|. .| | | 
qniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 195-255 6.3e-09 30.0 In-house 84-145 (350) alignment 
Range on Protein: 195-255
Range on HMM: 84-145/350.0
DpnivyYIHANHIMFD----HLKK--TYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSSSASNPN
|     || ||..       . .    || || ||| |..||. ..   ||. |.||||        
D.....YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek
0048179 (Phosphotyrosine protein) phosphatases II 261-392 8.8e-08 27.5 In-house 18-128 (144) alignment 
Range on Protein: 261-392
Range on HMM: 18-128/144.0
YPN---------------------------KpetfnnfgqffvycktvtqpktkygckeykfelvvqadneerrsVRLYHYPHWTKNMVPASSKVVLNLV
...                                                                        .  |..  |  . || ... .|...
taldlellkklgittvinlteeyepeflere............................................giqylhlpwpDhgvpdllelllefl

KKIGKK-KSQAPVVVQCETGVNQSAELVFVDAMCtlltrQVEVNFDVLFRQMRSQKALAM
. | .  ..  ||.| |  ||. .. ||  . |         ....  ....||.   | 
efieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgav
0048076 (Phosphotyrosine protein) phosphatases II 292-392 1e-07 27.3 In-house 27-126 (145) alignment 
Range on Protein: 292-392
Range on HMM: 27-126/145.0
EYKFELVVQAD---NEERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGKKKS-QAPVVVQCETGVNQSAELVFVDAMCTlltrqVEVNFDVLFRQMRSQ
.... .|.      . . | .  |.|  |  . || ... .|.... | .  .   ||.| |  ||. .. ||  . | .       |...  ....|||
dlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsq

KALAM
   | 
rpgav
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 305-390 3.1e-06 20.8 In-house 87-175 (440) alignment 
Range on Protein: 305-390
Range on HMM: 87-175/440.0
ERRSVRLYHYPHWTKNMVPASSKVVLNLVKKIGK---KKSQAPVVVQCETGVNQSAELVFVDAMCTLLTRQVEVNFDVLFRQMRSQKAL
| |... |||  |  . ||  .  ||.... . .   | ...|..|.| .|. ... .. ||..     |  ...   .   ||...  
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 213-276 6.6e-06 19.7 In-house 235-293 (440) alignment 
Range on Protein: 213-276
Range on HMM: 235-293/440.0
KKTYITTQHPLPGTLNDFWAMVADQKVETIVSLTSSssasNPNVYPMYYPNKPETFnNFGQFFV
|...|.|| ||  |. ||| .| | .. ||. |       | .   .|.| .  .   || | |
knafiatqmpldstvldfwrlvhdyristiimlnql....ndktcsiywpvntrsv.tfgpftv
PI-PLC-X Phosphatidylinositol-specific phospholipase C, X domain 296-370 9.4e-06 11.5 Pfam-A 44-113 (146) alignment 
Range on Protein: 296-370
Range on HMM: 44-113/146.0
ELVVQadNEERRSVRLYHYPHWTKNmvpASSKVVLNLVKKIGKKKSQAPVVVQCETGVNQSAELVFVDAMCTLLT
|| |.  . .. ... .|  . ||.    . | ||. .|.  .|.|. ||... |  .... .   .. . . . 
Eldvw..dgkdeepivlHgytltke...ikfkdvleaikeyafktssypvIlslenhcsaeqqekmaeilkeifg